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Search of human proteins with 14249254
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo
sapiens]
(395 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo sa... 791 0.0
gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo s... 743 0.0
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s... 743 0.0
gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens] 142 4e-34
gi|40255119 RAS and EF-hand domain containing [Homo sapiens] 88 2e-17
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 66 6e-11
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 66 6e-11
gi|148746195 trichohyalin [Homo sapiens] 65 8e-11
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 65 1e-10
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 64 2e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 64 2e-10
gi|42794779 myosin 18A isoform b [Homo sapiens] 64 2e-10
gi|28416946 myosin 18A isoform a [Homo sapiens] 64 2e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 60 3e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 60 3e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 60 3e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 60 3e-09
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 60 4e-09
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 59 6e-09
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 59 6e-09
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 59 6e-09
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 59 6e-09
gi|16262452 cingulin [Homo sapiens] 59 6e-09
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 58 1e-08
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 58 1e-08
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 58 1e-08
gi|38044112 restin isoform b [Homo sapiens] 57 2e-08
gi|4506751 restin isoform a [Homo sapiens] 57 2e-08
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 57 2e-08
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 57 3e-08
>gi|14249254 EF-hand calcium binding domain 4B isoform c [Homo
sapiens]
Length = 395
Score = 791 bits (2044), Expect = 0.0
Identities = 395/395 (100%), Positives = 395/395 (100%)
Query: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ
Sbjct: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
Query: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ
Sbjct: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK
Sbjct: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM
Sbjct: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE
Sbjct: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR
Sbjct: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
Query: 361 EKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV 395
EKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV
Sbjct: 361 EKAGLLKQLDFLRCVGGHWPVLRAPPRSLGSEGPV 395
>gi|222418793 EF-hand calcium binding domain 4B isoform b [Homo
sapiens]
Length = 462
Score = 743 bits (1917), Expect = 0.0
Identities = 373/373 (100%), Positives = 373/373 (100%)
Query: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ
Sbjct: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
Query: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ
Sbjct: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK
Sbjct: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM
Sbjct: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE
Sbjct: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR
Sbjct: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
Query: 361 EKAGLLKQLDFLR 373
EKAGLLKQLDFLR
Sbjct: 361 EKAGLLKQLDFLR 373
>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
sapiens]
Length = 731
Score = 743 bits (1917), Expect = 0.0
Identities = 373/373 (100%), Positives = 373/373 (100%)
Query: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ
Sbjct: 1 MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQ 60
Query: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ
Sbjct: 61 TCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQ 120
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK
Sbjct: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM
Sbjct: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE
Sbjct: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR
Sbjct: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
Query: 361 EKAGLLKQLDFLR 373
EKAGLLKQLDFLR
Sbjct: 361 EKAGLLKQLDFLR 373
>gi|150170653 EF-hand calcium binding domain 4A [Homo sapiens]
Length = 294
Score = 142 bits (359), Expect = 4e-34
Identities = 92/276 (33%), Positives = 153/276 (55%), Gaps = 14/276 (5%)
Query: 37 EQKETQEQTSG-QLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDA 95
E+ E + ++G + +L +A+E F CD E KGFI + D+Q L +LPL+ E+LE VF++
Sbjct: 15 EEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFES 74
Query: 96 LDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG-- 153
LD G+LT +EF G F + R E+ + S G + G G
Sbjct: 75 LDRAHTGFLTAREFCLGLGMFVGVASAQGANPC------RTPEETFESGGLDVQGTAGSL 128
Query: 154 ---EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQE 210
E+EE +F ++++LG VL + V+ LW +L++E P LL +FED L R + L+E
Sbjct: 129 DEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEE 188
Query: 211 AHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKL 270
A E++ LE AL+R+ + ++ E++ LYEE E Q++ + + ++ R + RS+ LE +L
Sbjct: 189 AARERDGLEQALRRRESEHEREVRALYEETE-QLREQSRRPPSQNFARGERRSR-LELEL 246
Query: 271 LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENT 306
+EQ+LE+ +Q+ G+ H ++ A T
Sbjct: 247 QSREQDLERAGLRQRERRGRRLQEHAERESQPATAT 282
>gi|40255119 RAS and EF-hand domain containing [Homo sapiens]
Length = 740
Score = 87.8 bits (216), Expect = 2e-17
Identities = 78/342 (22%), Positives = 152/342 (44%), Gaps = 28/342 (8%)
Query: 52 LRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTT 111
L + + F CDA G + R++ + L EL + + E VF LDAD +G +T QEF
Sbjct: 10 LARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFAR 69
Query: 112 GFSHFFFSQNN---------PSQEDAGEQVAQRHEEKVYLSRGDEDLG-----DMGEDEE 157
GF P+ +AG + E++ GDED G
Sbjct: 70 GFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDE-----GDEDAAAALATSCGPASP 124
Query: 158 AQ-FRMLMDRLGAQ-KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEK 215
+ ++ RLG + K + E V L+ + EP L+ +E + I +++ E
Sbjct: 125 GRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEM 184
Query: 216 NELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQ 275
L A+KR ++ L EEM+Q+I++ + + + + + +L ++ +
Sbjct: 185 ENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVG 244
Query: 276 ELEQLTQKQKRLEGQC--TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
+L+ +K ++LE Q + D K + L + NQ++ ++L + Q +L
Sbjct: 245 DLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSEL 304
Query: 334 ESLQQEAC--KLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
++L+ + L+ E+++E+ R + ++ L +Q++ L+
Sbjct: 305 DALKSDYADQSLNTERDLEIIR---AYTEDRNSLERQIEILQ 343
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 65.9 bits (159), Expect = 6e-11
Identities = 73/376 (19%), Positives = 172/376 (45%), Gaps = 25/376 (6%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVF 93
+ L++K + Q +LV K++ D + K + R + ++L + + L
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRK--LERAQLLLPQQQLQVEADRLGKEL 271
Query: 94 DALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG 153
++ A + E + + +E EQ + E+++ + +E +
Sbjct: 272 QSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQE 331
Query: 154 E---DEEAQFRMLMDRLGAQ--KVLEDESDVKQ----LWLQLKK--EEPHLLSNFEDFLT 202
E ++E + R D++ Q K+ E E +++ +W Q +K E+ + E+ +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 203 RIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-QFLLKDTERFQA 261
R +++E E++ E ++K+ DE+I+ EEM +Q + +E + +++D E
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE--- 448
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARE--- 318
+ +E+E+K+ ++E E++ +++++++ Q + + +T + LK + +E
Sbjct: 449 KLREVEEKM---QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKM 505
Query: 319 --LERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRCVG 376
E WE ++ Q+ E Q + +E+E+ +++ E +Q ++ L + + L +G
Sbjct: 506 WRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565
Query: 377 GHWPVLRAPPRSLGSE 392
+L R GS+
Sbjct: 566 QKAELLGGAGRESGSQ 581
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/211 (20%), Positives = 95/211 (45%), Gaps = 8/211 (3%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
QE+ ++ R E+K + DE + E EE +R +++++D+ + +
Sbjct: 400 QEEKRQEKMWRQEKK--MREQDEKIR---EQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI 244
+ +EE + E+ + R ++QE E+ E LK++ +++E + +E +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH---ET 301
+ EK Q + +R + + +E E +L +E+++++ + + LE + L
Sbjct: 515 QEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGA 574
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQ 332
E+ +L ++E S E Q QQQ
Sbjct: 575 GRESGSQRLPTLTPILQVELKSQEAQSLQQQ 605
Score = 34.3 bits (77), Expect = 0.20
Identities = 48/213 (22%), Positives = 90/213 (42%), Gaps = 27/213 (12%)
Query: 173 LEDESDVKQLWLQLKKE----------EPHLLSNFEDFLTRIISQLQEAHEEKNELECAL 222
LE+ D KQ LK+ E +S+ + + S ++ E+ NE
Sbjct: 90 LEESEDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKSSFKKRQEKMNEKNYTF 149
Query: 223 KRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQ------ARSQELEQKLLCKEQE 276
++++ ++ L E Q+ E LL++T F ++L ++ E
Sbjct: 150 RKRVVIKKPWLR-LGEVTAQK---RPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLE 205
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLES- 335
L + T + L+ + L ++E ++++L ++L R+LER L Q Q+E+
Sbjct: 206 LYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEAD 265
Query: 336 -----LQQEACKLH-QEKEMEVYRVTESLQREK 362
LQ + KL Q +E E++ + Q EK
Sbjct: 266 RLGKELQSVSAKLQAQVEENELWNLLNQQQEEK 298
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 65.9 bits (159), Expect = 6e-11
Identities = 73/376 (19%), Positives = 172/376 (45%), Gaps = 25/376 (6%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVF 93
+ L++K + Q +LV K++ D + K + R + ++L + + L
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRK--LERAQLLLPQQQLQVEADRLGKEL 271
Query: 94 DALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMG 153
++ A + E + + +E EQ + E+++ + +E +
Sbjct: 272 QSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQE 331
Query: 154 E---DEEAQFRMLMDRLGAQ--KVLEDESDVKQ----LWLQLKK--EEPHLLSNFEDFLT 202
E ++E + R D++ Q K+ E E +++ +W Q +K E+ + E+ +
Sbjct: 332 EKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMW 391
Query: 203 RIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE-QFLLKDTERFQA 261
R +++E E++ E ++K+ DE+I+ EEM +Q + +E + +++D E
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEE--- 448
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARE--- 318
+ +E+E+K+ ++E E++ +++++++ Q + + +T + LK + +E
Sbjct: 449 KLREVEEKM---QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKM 505
Query: 319 --LERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRCVG 376
E WE ++ Q+ E Q + +E+E+ +++ E +Q ++ L + + L +G
Sbjct: 506 WRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565
Query: 377 GHWPVLRAPPRSLGSE 392
+L R GS+
Sbjct: 566 QKAELLGGAGRESGSQ 581
Score = 40.4 bits (93), Expect = 0.003
Identities = 44/211 (20%), Positives = 95/211 (45%), Gaps = 8/211 (3%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
QE+ ++ R E+K + DE + E EE +R +++++D+ + +
Sbjct: 400 QEEKRQEKMWRQEKK--MREQDEKIR---EQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI 244
+ +EE + E+ + R ++QE E+ E LK++ +++E + +E +
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWE 514
Query: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH---ET 301
+ EK Q + +R + + +E E +L +E+++++ + + LE + L
Sbjct: 515 QEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGA 574
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQ 332
E+ +L ++E S E Q QQQ
Sbjct: 575 GRESGSQRLPTLTPILQVELKSQEAQSLQQQ 605
Score = 33.9 bits (76), Expect = 0.26
Identities = 31/119 (26%), Positives = 57/119 (47%), Gaps = 18/119 (15%)
Query: 251 FLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKL 310
++ K T+ A S EL + + E+ E+ + Q++L ++E ++++L
Sbjct: 191 YIEKLTKERDALSLELYRNTITDEELKEKNAELQEKLR-----------LVESEKSEIQL 239
Query: 311 TNQELARELERTSWELQDAQQQLES------LQQEACKLH-QEKEMEVYRVTESLQREK 362
++L R+LER L Q Q+E+ LQ + KL Q +E E++ + Q EK
Sbjct: 240 NVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEK 298
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 65.5 bits (158), Expect = 8e-11
Identities = 65/253 (25%), Positives = 119/253 (47%), Gaps = 26/253 (10%)
Query: 130 EQVAQRHEEK-------VYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQL 182
EQ +RHE+K L R E+ D + EE R +R Q + E + ++
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 183 WLQLKKEEPH-LLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME 241
WL+L++EE E L R + +E ++ E E L++++ + + + E E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 242 QQIKSEKEQFLLKDT-------------ERFQARSQELEQKLLCKEQELEQLTQKQKRLE 288
Q +K E+E+ L ++ ++ R +E Q+ L +EQE E+L Q+ KR E
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQE-ERLEQRLKREE 606
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKE 348
+ ++ E + + K + +E ++L ++ + + QQQL QQE + ++E
Sbjct: 607 VE----RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 349 MEVYRVTESLQRE 361
E R+ + L+RE
Sbjct: 663 EEEERLEQRLKRE 675
Score = 62.4 bits (150), Expect = 7e-10
Identities = 87/336 (25%), Positives = 160/336 (47%), Gaps = 37/336 (11%)
Query: 42 QEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGN 101
QEQ + +L++ +E Q + E + R++ +R ++E E+L+ + L +
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKR---RRQEQERQYREE----EQLQQEEEQLLREER 948
Query: 102 GYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFR 161
QE + Q Q E +R +E+ R +E+L + EE Q
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL----QQEEEQ-- 1002
Query: 162 MLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECA 221
+L + ++ E E ++ +L++EE LL E+ R + + + + E+ EL+
Sbjct: 1003 LLREEREKRRRQEWERQYRKKD-ELQQEEEQLLR--EEREKRRLQERERQYREEEELQQE 1059
Query: 222 LKRKIAAYDE-----EIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKE-- 274
++ + E E++ Y + E++++ E+EQ L ++ E+ R QE E++ C+E
Sbjct: 1060 EEQLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPEK--RRRQERERQ--CREEE 1114
Query: 275 ---QELEQLT--QKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAR--ELERTSWELQ 327
QE EQL +++KR + + ++ E + E +L E R ELER E +
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 328 DAQQQLESL-QQEACKLHQEKEMEVYRVTESLQREK 362
+ QQ+ E L ++E K QE+E + YR E LQR+K
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQ-YREEEELQRQK 1209
Score = 60.1 bits (144), Expect = 3e-09
Identities = 69/267 (25%), Positives = 127/267 (47%), Gaps = 37/267 (13%)
Query: 123 PSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES--- 177
P +E+ ++ QR E +++L + E+E+ Q R +L ++ + ED+
Sbjct: 812 PEEEEKEQRRRQRRER-------EKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR 864
Query: 178 ------DVKQLWL--QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAY 229
D K W + +K H L ++ + Q EE+ EL+ + K
Sbjct: 865 SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQ 924
Query: 230 DEEIQH-----LYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQ 284
++E Q+ L +E EQ ++ E+E+ ++ ER + ++L+QK +EQ L + +K+
Sbjct: 925 EQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK---EEQLLGEEPEKR 981
Query: 285 KRLEGQCTALHHDKHETKAENTKLKLTNQELARELE-----RTSWELQDAQQQLESLQQE 339
+R E + + ++ E + E +L +E R E R ELQ ++QL ++E
Sbjct: 982 RRQERE--KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLL 366
+L QE+E + YR E LQ+E+ LL
Sbjct: 1040 KRRL-QERERQ-YREEEELQQEEEQLL 1064
Score = 58.5 bits (140), Expect = 1e-08
Identities = 73/260 (28%), Positives = 119/260 (45%), Gaps = 48/260 (18%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
QE+ EQ +R EE+ L + + ++E + L+ R +K LE E ++L
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR-EEEKRLEQERREQRLKR 569
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE--MEQ 242
+ ++ LL E+ R +L+ EE+ LE LKR EE++ L +E EQ
Sbjct: 570 EQEERRDQLLKREEE---RRQQRLKREQEER--LEQRLKR------EEVERLEQEERREQ 618
Query: 243 QIK-----SEKEQFLLKDTERFQARSQEL-------EQKLLCKEQELEQLTQKQKRLEGQ 290
++K E+ Q LLK E+ + R Q+L ++ L +E+E E+L Q+ KR
Sbjct: 619 RLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR---- 674
Query: 291 CTALHHDKHETKAENTKLKLTNQELARE-----LERTSWELQ---DAQQQ---LESLQQE 339
+HE + +L QE ARE + + W+L+ DA+Q +QE
Sbjct: 675 -------EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 340 ACKLHQEKEMEVYRVTESLQ 359
+ QE+E + R LQ
Sbjct: 728 GQRRRQEQEEKRRRRESELQ 747
Score = 53.9 bits (128), Expect = 2e-07
Identities = 62/257 (24%), Positives = 122/257 (47%), Gaps = 25/257 (9%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGD-EDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
QE+ ++ + EE+ L + + ++L ++EE Q + L ++ E+E +Q
Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ-- 318
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQ 243
+ ++E+ E+ R QL+ EE+ E + +++ +++++ EE ++
Sbjct: 319 -EERREQQERREQQEE---RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 244 IKSEKEQFLLKDTERFQARSQELEQKL-----LCKEQEL---EQLTQKQKRLEGQCTALH 295
+ +EQ L ++ + + + EQ+L L +EQ+L +QL ++Q+ Q H
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH 434
Query: 296 HDKHETKAENTKLKLTNQE----LARELERTSWELQDAQQQLESLQQEA-----CKLHQE 346
KHE + +LK +E L RE E E + +QQL+ Q+E KL +E
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 347 KEMEVY-RVTESLQREK 362
+ E R + L+RE+
Sbjct: 495 ERREQQERREQQLRREQ 511
Score = 53.9 bits (128), Expect = 2e-07
Identities = 63/259 (24%), Positives = 117/259 (45%), Gaps = 15/259 (5%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDE--EAQFRMLMDRLGAQKVLEDES 177
+ QE+ EQ +R +E+ R ++ L E+E E Q R + ++ L E
Sbjct: 326 ERREQQEERREQQLRREQEE----RREQQLRREQEEERREQQLRREQEEERREQQLRREQ 381
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 237
+++ QL++E+ ++ + Q E++ E L+R+ E +H
Sbjct: 382 QLRREQ-QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQ 440
Query: 238 EEMEQQIKSEKEQFL--LKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALH 295
E EQ++K E+E+ LK E + QE ++ L ++QE E+ ++ +LE +
Sbjct: 441 ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE-EERRERWLKLEEEERREQ 499
Query: 296 HDKHETKAENTKLKLTNQELAR--ELERTSWELQDAQQ---QLESLQQEACKLHQEKEME 350
++ E + + + Q L R E ER L+ QQ + E +++ K +EK +E
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 351 VYRVTESLQREKAGLLKQL 369
R + L+RE+ QL
Sbjct: 560 QERREQRLKREQEERRDQL 578
Score = 53.5 bits (127), Expect = 3e-07
Identities = 57/255 (22%), Positives = 117/255 (45%), Gaps = 15/255 (5%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFR---MLMDRLGAQKVLEDESDVKQ 181
Q++A + + EEK L R + + ++ + +FR L+ Q + E D K
Sbjct: 1304 QKEAKRRDRKSQEEKQLL-REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKF 1362
Query: 182 LWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME 241
+L+ +E E+ R + ++ +E+ +L C + + D + + + E E
Sbjct: 1363 REEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK--FREEE 1420
Query: 242 QQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC------TALH 295
QQ+ ++ ++ E+ Q R QE E+K L +EQ+L Q ++ R E Q LH
Sbjct: 1421 QQLSRQERDRKFREEEQ-QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 296 HDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVT 355
+ + K + +L QE R+ EL+ + + + L++E Q+++ + +
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQ--ELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 356 ESLQREKAGLLKQLD 370
+ L+R++ G ++ D
Sbjct: 1538 QQLRRQERGQQRRQD 1552
Score = 52.4 bits (124), Expect = 7e-07
Identities = 78/346 (22%), Positives = 152/346 (43%), Gaps = 43/346 (12%)
Query: 37 EQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDAL 96
E++ QE+ QL + ++F E + + R++ R +E L +E E F L
Sbjct: 1466 EEQLLQEREEQQLHRQERDRKFL-----EEEQQLRRQERDRKFREQELRSQEPERKF--L 1518
Query: 97 DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQ------RHEEKVYLSRGDEDLG 150
+ + + ++ F + +++ G+Q Q R EE++ R ++ L
Sbjct: 1519 EEEQQLHRQQRQ-----RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 151 DMGEDEEAQFRMLMDRLGAQ----KVLEDESDVKQL--WLQLKKEEPHLLSNFEDFLTRI 204
++ + +FR+ ++ Q K +EDE +++ QL++E E L
Sbjct: 1574 R--QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631
Query: 205 ISQL---QEAHEEKNELECALKR----------KIAAYDEEIQHLYEEMEQQIKSEKEQF 251
Q QE + E E L+R + + EE Q L E EQQ++ ++
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 252 LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLT 311
++ E+ Q R QE E+K L +EQ+L + ++K E + ++ + + + K+
Sbjct: 1692 KFREEEQ-QLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 312 NQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTES 357
+E R ER +L+ ++ + ++E +L QE+E + R ES
Sbjct: 1751 EEEQLRP-EREEQQLRRQERDRKFREEE--QLRQEREEQQLRSQES 1793
Score = 51.2 bits (121), Expect = 2e-06
Identities = 81/356 (22%), Positives = 153/356 (42%), Gaps = 47/356 (13%)
Query: 36 LEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQR-LHKELPLSLEELEDVFD 94
LE+++ + Q L++ Q+ + + +G R+D R +E L E E
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRR----QERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 95 ALDADGNGYLTPQEFTTGFSHFFFSQNNPS--QEDAGEQVAQRHEEKVYLSRGDEDLGDM 152
+ D L Q+ F ++ +++ +Q+ Q + K R DE L +
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF---REDEQL--L 1628
Query: 153 GEDEEAQF-RMLMDRLGAQKVLEDESDVKQLWLQLK---------KEEPHLLSNFEDFLT 202
E EE Q R DR K LE+E +++ + + +EE LL E+
Sbjct: 1629 QEREEQQLHRQERDR----KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQL 1684
Query: 203 RIISQLQEAHEEKNELECALKRKIAAYDE------EIQHLYEEMEQQIKSEKEQFLLKDT 256
R + ++ EE+ +L + + +E E++ + E E+Q++ E EQ L+
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFRE-EEQLRQETEQEQLRRQ 1743
Query: 257 ERF-------QARSQELEQKLLCKEQE---LEQLTQKQKRLEGQCTALHHDKHETKAENT 306
ER+ Q R + EQ+L +E++ E+ +Q+R E Q + D+ + E
Sbjct: 1744 ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQL 1803
Query: 307 KLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
+ + Q+L + + ++ Q QLE +Q +L QE++ + YR E ++
Sbjct: 1804 RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ---RLRQERDRQ-YRAEEQFATQE 1855
Score = 50.1 bits (118), Expect = 4e-06
Identities = 66/310 (21%), Positives = 124/310 (40%), Gaps = 39/310 (12%)
Query: 63 DAEGKGFIARKDMQRL-HKELPLSLEELED------VFDALDADGNGYLTPQEFTTGFSH 115
D +G + +KD++ L +E L D + + LD D NG + EF
Sbjct: 22 DCDGAA-LTKKDLKNLLEREFGAVLRRPHDPKTVDLILELLDLDSNGRVDFNEFLL---- 76
Query: 116 FFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLED 175
F F G+ E++ + L D ++E+ + DR LE+
Sbjct: 77 FIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQ-----LEE 131
Query: 176 ESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH 235
E ++ + ++E +L E E+ + E +R DEE+
Sbjct: 132 EPGQRRRQKRQEQER----------------ELAEGEEQSEKQERLEQRDRQRRDEELWR 175
Query: 236 LYEEMEQQIKSEKEQFLLK-----DTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQ 290
+E +++ + E+ L+ +TE F Q ++LL ++ + Q+Q+R
Sbjct: 176 QRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD 235
Query: 291 CTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ-QEACKLHQEKEM 349
++ E + T L+ ++L E + ELQ+ ++QL L+ QE + QE+E
Sbjct: 236 RVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQ 295
Query: 350 EVYRVTESLQ 359
+ R+ Q
Sbjct: 296 QQQRLRREQQ 305
Score = 48.9 bits (115), Expect = 8e-06
Identities = 70/278 (25%), Positives = 124/278 (44%), Gaps = 42/278 (15%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDE--EAQFRMLMDRLGAQKVLEDESDVKQL 182
QE+ EQ +R +E+ R ++ L E+E E Q R Q++ ++ ++
Sbjct: 343 QEERREQQLRREQEE---ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 183 WL----QLKKEEP---HLLSNFEDFLTRIISQLQEAHEEKNELE---CALKRK------- 225
L QL++E+ E L R Q +E HE+K+E E LKR+
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRR--EQEEERHEQKHEQERREQRLKREQEERRDW 457
Query: 226 IAAYDEEIQHLYEEMEQQIKSEKEQ------FLLKDTERFQ---------ARSQELEQKL 270
+ +E +H E +QQ+K ++E+ L++ ER + R QE ++
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 271 LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQ 330
K QE E+ Q++ R E Q ++ E + + K QE R +R E ++ +
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE--RREQRLKREQEERR 575
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQ 368
QL ++E + ++E E R+ + L+RE+ L+Q
Sbjct: 576 DQLLKREEERRQQRLKREQE-ERLEQRLKREEVERLEQ 612
Score = 48.5 bits (114), Expect = 1e-05
Identities = 51/240 (21%), Positives = 108/240 (45%), Gaps = 12/240 (5%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQF-RMLMDRLGAQKVLEDESDVKQLWLQLKK 188
E+ Q +E+ R +E L + E EE Q R DR K LE+E +++ K
Sbjct: 1450 EEEQQLRQERHRKFREEEQL--LQEREEQQLHRQERDR----KFLEEEQQLRRQERDRKF 1503
Query: 189 EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEK 248
E L S + + + + Q+ H ++ + + + + E Q ++ +++ + E+
Sbjct: 1504 REQELRSQEPE--RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 249 EQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKL 308
+ L ++ E Q QE ++K +EQ++ + Q++K +E + + + +
Sbjct: 1562 Q--LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 309 KLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQ 368
K E + ER +L ++ + L++E QE+E ++ + RE+ LL++
Sbjct: 1620 KFREDEQLLQ-EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQE 1678
Score = 46.2 bits (108), Expect = 5e-05
Identities = 63/235 (26%), Positives = 111/235 (47%), Gaps = 26/235 (11%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLK-K 188
EQ+ Q EE+ L R + D E+E+ R +R K L++E +++ L+ K +
Sbjct: 1673 EQLLQEGEEQ-QLRRQERDR-KFREEEQQLRRQERER----KFLQEEQQLRRQELERKFR 1726
Query: 189 EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEK 248
EE L E QL+ + LE + ++ EE Q +E +++ + E+
Sbjct: 1727 EEEQLRQETEQ------EQLRRQERYRKILE---EEQLRPEREEQQLRRQERDRKFREEE 1777
Query: 249 EQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD-KHETKAENTK 307
+ L ++ E Q RSQE ++K +E EQL +Q+R E Q D K+ + E +
Sbjct: 1778 Q--LRQEREEQQLRSQESDRKF----REEEQL--RQEREEQQLRPQQRDGKYRWEEEQLQ 1829
Query: 308 LKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
L+ Q L +E +R + ++ E ++E +L QE+E + + E RE+
Sbjct: 1830 LEEQEQRLRQERDR-QYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883
Score = 45.4 bits (106), Expect = 9e-05
Identities = 87/372 (23%), Positives = 146/372 (39%), Gaps = 50/372 (13%)
Query: 36 LEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDA 95
LE++E +EQ + LR+ QE + + + R QRL E L E+ E
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ-QRLRSEQQLRREQEERREQL 549
Query: 96 LDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVY--LSRGDEDLGDMG 153
L + L + QE+ +Q+ +R EE+ L R E+ +
Sbjct: 550 LKREEEKRLEQERREQRLKR--------EQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Query: 154 EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAH- 212
E R+ + Q++ +E + ++ LK EE + L R + +E
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE--ERRQQQLRREQQERREQRL 659
Query: 213 ---EEKNELECALKRKIAAYDEEIQHLYEEMEQ--------------QIKSEKEQFLLKD 255
EE+ LE LKR+ E + EE EQ Q++SE + K
Sbjct: 660 KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 256 TER-----FQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD-----KHETKAEN 305
R Q R QE E+K +E EL+ +++ + Q D + E K+E
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSER 779
Query: 306 TKLKLTNQELARELERTSWELQDAQQ--------QLESLQQEACKLHQEKEMEVYRVTES 357
+ +L+ + RE ++ QQ + E Q+ + +EKE++ E
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 358 LQ-REKAGLLKQ 368
LQ RE+A L++
Sbjct: 840 LQRRERAQQLQE 851
Score = 45.1 bits (105), Expect = 1e-04
Identities = 55/225 (24%), Positives = 101/225 (44%), Gaps = 10/225 (4%)
Query: 154 EDEEAQFRMLMDRLGAQKV-LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAH 212
E+EE ++R L ++ L++E +Q LQ ++E+ L E R Q +E
Sbjct: 240 EEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE---LRRERQEEEQQ 296
Query: 213 EEKNELECALKRKIAA----YDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQ 268
+++ E L+RK EE + E EQQ + +EQ L ++ E + + EQ
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQ-EERREQQLRREQEERREQQLRREQ 355
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQD 328
+ +EQ+L + Q+++R E Q + E + + Q+L RE + +
Sbjct: 356 EEERREQQLRR-EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 329 AQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
+QQL QQ + +E+ + + QR K ++ D+L+
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Score = 44.7 bits (104), Expect = 1e-04
Identities = 50/254 (19%), Positives = 109/254 (42%), Gaps = 12/254 (4%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDV 179
+ + QE ++ QR +E+++ R + + EE Q + + E++
Sbjct: 153 EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 180 KQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKR-KIAAYDEEIQHLYE 238
++L +K + R+ + +E K E + K+ + + Q +
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 239 EMEQQIKSEKEQFLLKDTERFQARSQEL--EQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
E E+Q++ + Q L ++ + + + Q L EQ+L K++E + Q+++R + +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 297 DKHETKAENTKLKLTNQELARELE--------RTSWELQDAQQQLESLQQEACKLHQEKE 348
++ E + + + Q+L RE E R E + +QQL QQ + +E
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 349 MEVYRVTESLQREK 362
++ R + L+RE+
Sbjct: 393 QQLRR-EQQLRREQ 405
Score = 42.4 bits (98), Expect = 7e-04
Identities = 49/209 (23%), Positives = 94/209 (44%), Gaps = 21/209 (10%)
Query: 154 EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE 213
E+++ Q R DR+ + E+E + ++ L+KEE L ++ + +LQE E
Sbjct: 224 EEKQQQRRERQDRVFQE---EEEKEWRKRETVLRKEEEKL----QEEEPQRQRELQEEEE 276
Query: 214 EKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCK 273
+ +LE R+ EE +QQ + +EQ L + E + QE ++ +
Sbjct: 277 QLRKLERQELRR---------ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQER 327
Query: 274 EQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQL 333
++ E+ ++Q R E + + E + E + Q+L RE E E Q ++Q
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERRE-----QQLRREQEEERREQQLRREQQ 382
Query: 334 ESLQQEACKLHQEKEMEVYRVTESLQREK 362
+Q+ + Q + + R + L+RE+
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQ 411
Score = 42.4 bits (98), Expect = 7e-04
Identities = 61/291 (20%), Positives = 124/291 (42%), Gaps = 52/291 (17%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E+ E++ QR + + R +++L + E E+A+ R+ Q LE E+D +Q +
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEE-EQEQARERIKSRIPKWQWQLESEADARQSKV 719
Query: 185 QL---KKEEPHLLSNFEDFLTRIISQLQ-----EAHEEKNELECALKRKIAAYDEEIQHL 236
K+E E+ R S+LQ AH ++ E E +R+ + + +
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE---QRRDFTWQWQAEEK 776
Query: 237 YEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
E Q++ + ++ + Q+ EQ+ L +E+E EQ ++++ E + L
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 297 DKHETKAENTKL-------------KLTNQELARELERTSWELQD--------------- 328
++ + E + + +QE R+ ++ W+L++
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD-QKWRWQLEEERKRRRHTLYAKPAL 895
Query: 329 ----------AQQQLESLQQEACKLHQEKEME-VYRVTESLQREKAGLLKQ 368
Q++ E LQ+E + + +E E YR E LQ+E+ LL++
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE 946
Score = 42.0 bits (97), Expect = 0.001
Identities = 56/259 (21%), Positives = 114/259 (44%), Gaps = 38/259 (14%)
Query: 117 FFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDE 176
F ++ +E+ G++ Q+ +E+ + +L + E E Q R+ ++ Q+ E+
Sbjct: 122 FEPRDRQLEEEPGQRRRQKRQEQ------ERELAEGEEQSEKQERL--EQRDRQRRDEEL 173
Query: 177 SDVKQLWL----------QLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKI 226
+Q W QL+ + H F D +L E + E + +R
Sbjct: 174 WRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRR-- 231
Query: 227 AAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKR 286
E +++E E++ ++E L K+ E+ Q + +++L +E++L +L +++ R
Sbjct: 232 ----ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 287 LEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDA---QQQLESLQQEACKL 343
E Q E + + +L+ Q+L R+ E E Q+ QQ+ Q+E +
Sbjct: 288 RERQ---------EEEQQQQRLR-REQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 344 HQEKEMEVYRVTESLQREK 362
+E E R + L+RE+
Sbjct: 338 QLRREQEERR-EQQLRREQ 355
Score = 38.1 bits (87), Expect = 0.014
Identities = 59/272 (21%), Positives = 118/272 (43%), Gaps = 50/272 (18%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKE 189
E +R +E+ R +E+L E + R R ++ +E +V+Q QL +E
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNEL-----ECALKRKIAAYDEEIQHLYEEMEQQI 244
EP E L R + +E +E+ +L E + + Y EE + ++ +Q+
Sbjct: 1157 EPEKRRRQE--LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 245 KSE-----------------------------KEQFL-LKDTERFQARSQELEQKLLCKE 274
+ E EQF L+D++ +SQ+ Q LL ++
Sbjct: 1215 RDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQ 1274
Query: 275 QELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWE----LQDAQ 330
QE ++ Q+++R + D+H + E +L+ Q+ A+ +R S E L++ +
Sbjct: 1275 QERDR-EQERRRWQ------QRDRHFPEEE--QLEREEQKEAKRRDRKSQEEKQLLREER 1325
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
++ Q+ K +E+++ R + L+R++
Sbjct: 1326 EEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Score = 30.8 bits (68), Expect = 2.2
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 27/144 (18%)
Query: 135 RHEEKVYLSRGDEDLGDMGED----EEAQFRMLMDRLGAQKVLEDESDVKQLW----LQL 186
R EE++ R ++ L D EE Q R + Q++ + D K W LQL
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE---QQLRPQQRDGKYRWEEEQLQL 1830
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKS 246
+++E L + + ++ Q A +EK+ E Q L++E EQ+ +
Sbjct: 1831 EEQEQRLRQERD---RQYRAEEQFATQEKSR-------------REEQELWQEEEQKRRQ 1874
Query: 247 EKEQFLLKDTERFQARSQELEQKL 270
E+E+ L ++ R Q + ++ +++
Sbjct: 1875 ERERKLREEHIRRQQKEEQRHRQV 1898
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 64.7 bits (156), Expect = 1e-10
Identities = 65/279 (23%), Positives = 130/279 (46%), Gaps = 33/279 (11%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLM----------DRLGAQKV-- 172
++ A E + EE V L++ E + D+ + R L+ D+L ++ V
Sbjct: 113 EQKAKETILALKEEIVNLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKL 172
Query: 173 ---LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKR----- 224
L ++ +Q + K+E H +S F+ + + ++ +K +LE LK+
Sbjct: 173 RESLAQTTEQQQETERSKEEAEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADM 232
Query: 225 -----KIAAYDEEIQHLYEEM---EQQIKSEK--EQFLLKDTERFQARSQELEQKLLCKE 274
+I A + +Q EE+ EQQ+K +K + K+ E+FQ R+ +L+Q+
Sbjct: 233 DSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHS 292
Query: 275 QELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLE 334
EQL+Q+ ++ + A + H+ + + KL +++ ++L T + + +Q E
Sbjct: 293 LVCEQLSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQKAEVEQHKE 352
Query: 335 SLQQEACKLHQEKEMEVYRVTESLQREKAG-LLKQLDFL 372
+L+ + L E+E+E + L R+ LL++ D L
Sbjct: 353 TLKNQIVGL--EREVEASKKQAELDRKAMDELLRERDIL 389
Score = 42.7 bits (99), Expect = 6e-04
Identities = 54/248 (21%), Positives = 109/248 (43%), Gaps = 19/248 (7%)
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDR--LGAQKVLEDESDVKQLWLQLKKEEPHLL 194
E +V S+ +L DE + R ++++ L A + ++D+ +L Q K+ +
Sbjct: 362 EREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEI 421
Query: 195 SNFEDFLTR---IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM--------EQQ 243
N++D + II L++ + L +K+ E+I+ ++ E +
Sbjct: 422 QNYKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMNMEDIKVRETQIFDYRKKIAESE 481
Query: 244 IKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKA 303
IK +++Q L E ++ + L+ + E+ + +K K + Q L D ++
Sbjct: 482 IKLKQQQNLY---EAVRSDRNLYSKNLVEAQDEITDMKRKLKIMIHQVDELKEDISAKES 538
Query: 304 ENTKLKLTNQELARELERTSWELQDAQQQ-LESLQQEACKLHQEKEMEVYRVTESLQREK 362
KL L Q + +E E ELQ +QQ LE+ + + + +E ++ R+ E+
Sbjct: 539 ALVKLHLEQQRIEKEKETLKAELQKLRQQALET--KHFIEKQEAEERKLLRIIAEADGER 596
Query: 363 AGLLKQLD 370
K+LD
Sbjct: 597 LRQKKELD 604
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 64.3 bits (155), Expect = 2e-10
Identities = 44/235 (18%), Positives = 122/235 (51%), Gaps = 11/235 (4%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES 177
Q + GEQ Q E++ + + +E +G+ +E Q R +++G Q+ V + E
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE----QEEQMRKQEEQMGEQEEQVQKQEE 248
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE-EKNELECALKRKIAAYDEEIQHL 236
V++ Q++K+E + E + L++ + E+ E + ++ +E+++
Sbjct: 249 QVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQ 308
Query: 237 YEEM---EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTA 293
E+M E+Q++ ++EQ ++ + ++ + Q EQK +QE EQ+ +++++++ Q
Sbjct: 309 EEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQE-EQMGEQEEQMQKQEEQ 367
Query: 294 LHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKE 348
+ + + + + +++ +++ ++ E+ + + +Q E ++++ ++ ++KE
Sbjct: 368 VRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKE 422
Score = 52.0 bits (123), Expect = 9e-07
Identities = 50/267 (18%), Positives = 129/267 (48%), Gaps = 16/267 (5%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES 177
Q +E G+ Q + + + E G + E +E Q R ++ Q+ V E E
Sbjct: 127 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQVREQEGQVREQEGQVREQEG 185
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRK---IAAYDEEIQ 234
V++ Q+ ++E + E+ + Q+Q+ E+ E E ++++ + +E++Q
Sbjct: 186 QVREQEGQMGEQEGQM-GEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQ 244
Query: 235 HLYEEM---EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQEL-----EQLTQKQKR 286
E++ E+Q++ ++EQ ++ + + Q L+QK +++E EQ+ +++++
Sbjct: 245 KQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQ 304
Query: 287 LEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQE 346
+ Q + + + + + ++ +++ + E+ WE ++ + E E + Q+
Sbjct: 305 MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ-MWEQKEQMWKQEEQMGEQEEQMQK 363
Query: 347 KEMEVYRVTESLQREKAGLLKQLDFLR 373
+E +V + E +++++ + KQ + +R
Sbjct: 364 QEEQVRKQEEQMRKQEEQMRKQEEQMR 390
Score = 49.7 bits (117), Expect = 5e-06
Identities = 46/247 (18%), Positives = 114/247 (46%), Gaps = 6/247 (2%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDES 177
Q +E G+ Q + + + E G + E +E Q R ++ Q+ V E E
Sbjct: 85 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE-QEGQVREQEGQVREQEGQVREQEG 143
Query: 178 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY 237
V++ Q++++E + E + Q++E + E E ++ + E+ +
Sbjct: 144 QVREQEGQVREQEGQVREQ-EGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMG 202
Query: 238 EEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD 297
E+ EQ E+E+ + K E+ + +++ ++ ++ EQ+ +++++++ Q +
Sbjct: 203 EQEEQM--GEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQ 260
Query: 298 KHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTES 357
+ + + + +++ +++ ++ E+T E Q +Q+ + +QE QE++M
Sbjct: 261 EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320
Query: 358 LQREKAG 364
Q E+ G
Sbjct: 321 EQEEQMG 327
Score = 44.3 bits (103), Expect = 2e-04
Identities = 56/285 (19%), Positives = 126/285 (44%), Gaps = 37/285 (12%)
Query: 5 DGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDA 64
+G+V + ++G+ GQ + + ++++E EQ Q +RK +E Q +
Sbjct: 184 EGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQE--EQMGEQEEQMRKQEE--QMGEQ 239
Query: 65 EGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPS 124
E + + +Q+ +++ E++ + + + L +E T
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTE------------Q 287
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
+E GEQ Q E++ + +E + ++E Q R +++G Q+ +Q+W
Sbjct: 288 EEQTGEQEEQMREQEEQMREQEEQM----REQEEQMREQEEQMGKQE--------EQMWE 335
Query: 185 QLKK--EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM-- 240
Q ++ E+ + E+ + Q+Q+ E+ + E ++++ +E+++ E+M
Sbjct: 336 QKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQ----EEQMRKQEEQMRK 391
Query: 241 -EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQ 284
E+Q+ +KEQ + + + Q EQK ++QE QK+
Sbjct: 392 QEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 64.3 bits (155), Expect = 2e-10
Identities = 77/356 (21%), Positives = 158/356 (44%), Gaps = 37/356 (10%)
Query: 36 LEQKETQEQTSGQLV-MLRKAQEFFQTCDAEGKGFIARKDM----QRLHKELPLSLEELE 90
L+ KE Q + G+L M RK Q+ + + + A ++ + + L +ELE
Sbjct: 862 LKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELE 921
Query: 91 DVFDALDA-----DGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHE--EKVYLS 143
++ L++ + + E +H + +E+ Q Q + + +
Sbjct: 922 EILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIK 981
Query: 144 RGDEDLGDMGEDEEAQF----RMLMDRLG--AQKVLEDESDVKQLWLQLKKEEPHLLSNF 197
+ +E++ + ED+ ++F +++ DR+ + ++ E+E K L +++ ++ ++S+
Sbjct: 982 KMEEEILLL-EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL-AKIRNKQEVMISDL 1039
Query: 198 EDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE 257
E+ +L++ + + ELE A KRK+ ++Q E++ QI K Q L K E
Sbjct: 1040 EE-------RLKKEEKTRQELEKA-KRKLDGETTDLQDQIAELQAQIDELKLQ-LAKKEE 1090
Query: 258 RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAR 317
Q + + L K L+ + + L+ Q L D KA K + ++L+
Sbjct: 1091 ELQGALARGDDETLHKNNALKVV----RELQAQIAELQEDFESEKASRNKAEKQKRDLSE 1146
Query: 318 ELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
ELE EL+D + Q+ L ++E EV + ++L+ E Q+ +R
Sbjct: 1147 ELEALKTELEDTLDTTAAQQE----LRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Score = 51.2 bits (121), Expect = 2e-06
Identities = 69/332 (20%), Positives = 138/332 (41%), Gaps = 56/332 (16%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AE KG KD L +L + E L E+ L+ +E +N
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEE-----------KN 1346
Query: 122 NPSQEDAGEQVAQRHEEKVYLS----------RGDEDLGDMGEDEEAQFRMLMDRLGAQK 171
+ ++ E+ A+++ EK L+ + D+DLG + EEA+ ++L D +
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 172 VLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE 231
LE+++ + +L+K + L +D + Q R++A+ E
Sbjct: 1407 RLEEKA---LAYDKLEKTKNRLQQELDDLTVDLDHQ----------------RQVASNLE 1447
Query: 232 EIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
+ Q ++++ + KS ++ ++ +R +A ++E E K L + LE+ + ++ E Q
Sbjct: 1448 KKQKKFDQLLAEEKSISARYA-EERDRAEAEAREKETKALSLARALEEALEAKEEFERQN 1506
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEA-----CKLHQE 346
L D + + + EL + ++++ + QLE L+ E KL E
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566
Query: 347 KEMEVYRVT---------ESLQREKAGLLKQL 369
M+ + E + +K L+KQ+
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Score = 47.0 bits (110), Expect = 3e-05
Identities = 74/339 (21%), Positives = 138/339 (40%), Gaps = 28/339 (8%)
Query: 37 EQKETQEQTSGQLVMLRKAQ----EFFQTCDAEGKGFIAR-KDMQRLH----KELPLSLE 87
E ++T + T+ Q + K + E + + E K A+ +DM++ H +EL LE
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213
Query: 88 ELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDE 147
+ + L+ + G T + S+ + AQ E +S GD
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273
Query: 148 DLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQ 207
++ E L + L L +E++ K + + K+ L S +D
Sbjct: 1274 LRVELAEKASK----LQNELDNVSTLLEEAEKKGI--KFAKDAASLESQLQD-------- 1319
Query: 208 LQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELE 267
QE +E+ + L +I +EE L E+ E++ ++ K L K Q++ + +
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKN--LEKQVLALQSQLADTK 1377
Query: 268 QKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQ 327
+K+ +E L + +K+L AL E KL+ T L +EL+ + +L
Sbjct: 1378 KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLD 1437
Query: 328 DAQQQLESLQQEACKLHQ---EKEMEVYRVTESLQREKA 363
+Q +L+++ K Q E++ R E R +A
Sbjct: 1438 HQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1476
Score = 45.1 bits (105), Expect = 1e-04
Identities = 81/366 (22%), Positives = 156/366 (42%), Gaps = 64/366 (17%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+ + QL ++ + D GK +++ +++ +E+ LEEL
Sbjct: 1494 EALEAKEEFERQNKQL--RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F + D + Q E+K L + +
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQF-----------ERDLQTRDEQNEEKKRLLIKQVRE 1600
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLK----------KEEPHLLSNFE 198
L EDE Q + + ++K +E D+K L Q++ K+ L + +
Sbjct: 1601 LEAELEDERKQRALAV---ASKKKME--IDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 199 DFLTRIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKE 249
D+ +L+EA ++E+ K +K+ + + EI L EE+ + + E++
Sbjct: 1656 DYQR----ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 250 QF-------------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
+ LL + R +AR +LE++L ++ +E L + ++ Q L+
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN- 1770
Query: 297 DKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLH-QEKEMEVYRVT 355
E AE + + + ++LER + EL+ Q+LE + K E ++ ++
Sbjct: 1771 --AELAAERSAAQ-KSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 356 ESLQRE 361
E L++E
Sbjct: 1828 EQLEQE 1833
Score = 43.5 bits (101), Expect = 3e-04
Identities = 48/211 (22%), Positives = 90/211 (42%), Gaps = 19/211 (9%)
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSN 196
+EK L L + E+E++ +L DR + D + + L ++ N
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE---LAAERSAAQKSDN 1785
Query: 197 FEDFLTRIISQLQEAHEEKNELECALKRK----IAAYDEEIQHLYEEMEQQIKSEKEQFL 252
L R Q +E + ELE A+K K I+A + +I L E++EQ+ K
Sbjct: 1786 ARQQLER---QNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANK 1842
Query: 253 LKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTN 312
L R + + +E+ ++ + + +Q ++ ++ + L E + E T+ +
Sbjct: 1843 L--VRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASR 1900
Query: 313 QELARELERTSWELQDAQQQLESLQQEACKL 343
++L REL+ DA + E L +E L
Sbjct: 1901 RKLQRELD-------DATEANEGLSREVSTL 1924
Score = 33.9 bits (76), Expect = 0.26
Identities = 28/115 (24%), Positives = 52/115 (45%), Gaps = 16/115 (13%)
Query: 267 EQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAE-----------NTKLKLTNQEL 315
E++L K++EL ++ +KQ ++EG+ + KH+ E T+L +E+
Sbjct: 851 EEELQAKDEELLKVKEKQTKVEGELEEMER-KHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
L EL++ LES +E +E+ + + +Q L +QLD
Sbjct: 910 RARLAAKKQELEEILHDLESRVEE----EEERNQILQNEKKKMQAHIQDLEEQLD 960
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 64.3 bits (155), Expect = 2e-10
Identities = 62/241 (25%), Positives = 113/241 (46%), Gaps = 19/241 (7%)
Query: 126 EDAGEQVAQRHEEKVY-----LSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
+DAG + ++E V R ++ D E E+ R L RLG + +ES +
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEES--Q 1422
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
+ QLKK+ L + +D + Q HE L++K +D E+ +EE
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHE--------LEKKQRRFDSELSQAHEEA 1474
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
+++ K ++E+ L ++ + A + L+Q+L K+ ++ TQK LE + + + +
Sbjct: 1475 QRE-KLQREK-LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+A K+K ++L +++ EL + ++ L+Q KL E EME R T S +
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQ--AKLRLEMEMERMRQTHSKEM 1590
Query: 361 E 361
E
Sbjct: 1591 E 1591
Score = 45.8 bits (107), Expect = 7e-05
Identities = 56/238 (23%), Positives = 120/238 (50%), Gaps = 32/238 (13%)
Query: 129 GEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDESDVKQLWLQL 186
G+QV + HE + R D +L E+ + + ++ ++L +K +L + +KQ QL
Sbjct: 1448 GQQV-RNHELEKKQRRFDSELSQAHEEAQRE-KLQREKLQREKDMLLAEAFSLKQ---QL 1502
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECAL---KRKIAAYDEEIQHLYEEMEQQ 243
++++ + + F + + ++LQ+ ++++ E +L K+++ + +++ EE+++Q
Sbjct: 1503 EEKDMDI-AGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1561
Query: 244 IKSEK--EQFLLK---DTERF-QARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD 297
+ + EQ L+ + ER Q S+E+E + E+ + +K K++E Q + D
Sbjct: 1562 AGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1621
Query: 298 KHETKAENTKLK-----LTNQ----------ELARELERTSWELQDAQQQLESLQQEA 340
K + E +L+ L++Q L ++L+RT L DAQ L+ L+ A
Sbjct: 1622 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSA 1679
Score = 45.1 bits (105), Expect = 1e-04
Identities = 42/198 (21%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 156 EEAQFRMLMDRLGAQKVLE-DESDVKQLWLQLKKEEPHLLSNFEDF--LTRIISQLQEAH 212
EE R+ ++ Q LE D+ D+ +L +KK + + D + + +QL+EA+
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNEL---MKKHKAAVAQASRDLAQINDLQAQLEEAN 1787
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE-----------RFQA 261
+EK EL+ K+ A +++ L + M + +++ +++ E R ++
Sbjct: 1788 KEKQELQ----EKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLES 1843
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELER 321
+ L++ + +E +Q + R + Q L +TK E +L E +R+
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Query: 322 TSWELQDAQQQLESLQQE 339
+L+ + +SLQ +
Sbjct: 1904 LEMDLESLEAANQSLQAD 1921
Score = 43.1 bits (100), Expect = 4e-04
Identities = 54/210 (25%), Positives = 97/210 (46%), Gaps = 26/210 (12%)
Query: 163 LMDRLGAQKVLEDESDVKQLWLQ---LKKE-EPHLLSNFEDFLTRIISQLQEAHEEKNEL 218
L+D A++ L E ++K+L Q LKK+ E + E L R E ++
Sbjct: 1311 LLDAETAER-LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369
Query: 219 ECALK--RKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQE 276
E LK R + D + L +E E +++ E Q ++LE++L + +
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLEVE------------QQNKRQLERRLGDLQAD 1417
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQ--QLE 334
E+ + ++L+ +C L + +TK ++ N EL ++ R EL A + Q E
Sbjct: 1418 SEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQRE 1477
Query: 335 SLQQEACKLHQEKEM---EVYRVTESLQRE 361
LQ+E KL +EK+M E + + + L+ +
Sbjct: 1478 KLQRE--KLQREKDMLLAEAFSLKQQLEEK 1505
Score = 40.0 bits (92), Expect = 0.004
Identities = 76/353 (21%), Positives = 143/353 (40%), Gaps = 48/353 (13%)
Query: 37 EQKETQEQTSGQLVM---LRKAQEFFQTCDAEGKGFIARKDMQR--LHKELPLSLEE--- 88
E ++T+ GQ V L K Q F + ++ R+ +QR L +E + L E
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 89 LEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
L+ + D D G+ SQ + + + Q + + + +E+
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEE 1557
Query: 149 LGD------MGEDEEAQFRMLMDRLGAQKVLEDESDVKQL-------WLQLKKEEPHLLS 195
L + M E + + M M+R+ E ES +++ +LK+ E L
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 196 NFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKD 255
+ED Q+ EK ELE K+A +++ E E++++ + LK
Sbjct: 1618 EYED--------KQKVLREKRELE----GKLATLSDQVNRRDFESEKRLRKD-----LKR 1660
Query: 256 TERFQARSQELEQKL---LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTN 312
T+ A +Q + L ++E+ QL + + E C A + + E L L
Sbjct: 1661 TKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 313 QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGL 365
++A+ +T+ E +QL LQ+E ++ E + + E +++ KA +
Sbjct: 1721 DDIAKA--KTALE-----EQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAV 1766
Score = 33.1 bits (74), Expect = 0.45
Identities = 33/137 (24%), Positives = 62/137 (45%), Gaps = 13/137 (9%)
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
+++ +EQ KD E Q+L KL E+E +L RLE + + E
Sbjct: 1248 EVQLSEEQIRNKDEE-----IQQLRSKLEKAEKERNELRLNSDRLESRIS-------ELT 1295
Query: 303 AENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
+E T + T + ++ L+ + E A+++++ LQ + L ++ E+ V E+
Sbjct: 1296 SELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA 1355
Query: 363 AGLLKQLDFLRCVGGHW 379
A + ++D GG W
Sbjct: 1356 AEINGEVDD-DDAGGEW 1371
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 64.3 bits (155), Expect = 2e-10
Identities = 62/241 (25%), Positives = 113/241 (46%), Gaps = 19/241 (7%)
Query: 126 EDAGEQVAQRHEEKVY-----LSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVK 180
+DAG + ++E V R ++ D E E+ R L RLG + +ES +
Sbjct: 1365 DDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEES--Q 1422
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
+ QLKK+ L + +D + Q HE L++K +D E+ +EE
Sbjct: 1423 RALQQLKKKCQRLTAELQDTKLHLEGQQVRNHE--------LEKKQRRFDSELSQAHEEA 1474
Query: 241 EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
+++ K ++E+ L ++ + A + L+Q+L K+ ++ TQK LE + + + +
Sbjct: 1475 QRE-KLQREK-LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESK 1532
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+A K+K ++L +++ EL + ++ L+Q KL E EME R T S +
Sbjct: 1533 DEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQ--AKLRLEMEMERMRQTHSKEM 1590
Query: 361 E 361
E
Sbjct: 1591 E 1591
Score = 45.8 bits (107), Expect = 7e-05
Identities = 56/238 (23%), Positives = 120/238 (50%), Gaps = 32/238 (13%)
Query: 129 GEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQK--VLEDESDVKQLWLQL 186
G+QV + HE + R D +L E+ + + ++ ++L +K +L + +KQ QL
Sbjct: 1448 GQQV-RNHELEKKQRRFDSELSQAHEEAQRE-KLQREKLQREKDMLLAEAFSLKQ---QL 1502
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECAL---KRKIAAYDEEIQHLYEEMEQQ 243
++++ + + F + + ++LQ+ ++++ E +L K+++ + +++ EE+++Q
Sbjct: 1503 EEKDMDI-AGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQ 1561
Query: 244 IKSEK--EQFLLK---DTERF-QARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHD 297
+ + EQ L+ + ER Q S+E+E + E+ + +K K++E Q + D
Sbjct: 1562 AGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYED 1621
Query: 298 KHETKAENTKLK-----LTNQ----------ELARELERTSWELQDAQQQLESLQQEA 340
K + E +L+ L++Q L ++L+RT L DAQ L+ L+ A
Sbjct: 1622 KQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSA 1679
Score = 45.1 bits (105), Expect = 1e-04
Identities = 42/198 (21%), Positives = 89/198 (44%), Gaps = 21/198 (10%)
Query: 156 EEAQFRMLMDRLGAQKVLE-DESDVKQLWLQLKKEEPHLLSNFEDF--LTRIISQLQEAH 212
EE R+ ++ Q LE D+ D+ +L +KK + + D + + +QL+EA+
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNEL---MKKHKAAVAQASRDLAQINDLQAQLEEAN 1787
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE-----------RFQA 261
+EK EL+ K+ A +++ L + M + +++ +++ E R ++
Sbjct: 1788 KEKQELQ----EKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLES 1843
Query: 262 RSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELER 321
+ L++ + +E +Q + R + Q L +TK E +L E +R+
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903
Query: 322 TSWELQDAQQQLESLQQE 339
+L+ + +SLQ +
Sbjct: 1904 LEMDLESLEAANQSLQAD 1921
Score = 43.1 bits (100), Expect = 4e-04
Identities = 54/210 (25%), Positives = 97/210 (46%), Gaps = 26/210 (12%)
Query: 163 LMDRLGAQKVLEDESDVKQLWLQ---LKKE-EPHLLSNFEDFLTRIISQLQEAHEEKNEL 218
L+D A++ L E ++K+L Q LKK+ E + E L R E ++
Sbjct: 1311 LLDAETAER-LRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369
Query: 219 ECALK--RKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQE 276
E LK R + D + L +E E +++ E Q ++LE++L + +
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLEVE------------QQNKRQLERRLGDLQAD 1417
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQ--QLE 334
E+ + ++L+ +C L + +TK ++ N EL ++ R EL A + Q E
Sbjct: 1418 SEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQRE 1477
Query: 335 SLQQEACKLHQEKEM---EVYRVTESLQRE 361
LQ+E KL +EK+M E + + + L+ +
Sbjct: 1478 KLQRE--KLQREKDMLLAEAFSLKQQLEEK 1505
Score = 40.0 bits (92), Expect = 0.004
Identities = 76/353 (21%), Positives = 143/353 (40%), Gaps = 48/353 (13%)
Query: 37 EQKETQEQTSGQLVM---LRKAQEFFQTCDAEGKGFIARKDMQR--LHKELPLSLEE--- 88
E ++T+ GQ V L K Q F + ++ R+ +QR L +E + L E
Sbjct: 1438 ELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFS 1497
Query: 89 LEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
L+ + D D G+ SQ + + + Q + + + +E+
Sbjct: 1498 LKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEE 1557
Query: 149 LGD------MGEDEEAQFRMLMDRLGAQKVLEDESDVKQL-------WLQLKKEEPHLLS 195
L + M E + + M M+R+ E ES +++ +LK+ E L
Sbjct: 1558 LDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEE 1617
Query: 196 NFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKD 255
+ED Q+ EK ELE K+A +++ E E++++ + LK
Sbjct: 1618 EYED--------KQKVLREKRELE----GKLATLSDQVNRRDFESEKRLRKD-----LKR 1660
Query: 256 TERFQARSQELEQKL---LCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTN 312
T+ A +Q + L ++E+ QL + + E C A + + E L L
Sbjct: 1661 TKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQI 1720
Query: 313 QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGL 365
++A+ +T+ E +QL LQ+E ++ E + + E +++ KA +
Sbjct: 1721 DDIAKA--KTALE-----EQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAV 1766
Score = 33.1 bits (74), Expect = 0.45
Identities = 33/137 (24%), Positives = 62/137 (45%), Gaps = 13/137 (9%)
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
+++ +EQ KD E Q+L KL E+E +L RLE + + E
Sbjct: 1248 EVQLSEEQIRNKDEE-----IQQLRSKLEKAEKERNELRLNSDRLESRIS-------ELT 1295
Query: 303 AENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
+E T + T + ++ L+ + E A+++++ LQ + L ++ E+ V E+
Sbjct: 1296 SELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRA 1355
Query: 363 AGLLKQLDFLRCVGGHW 379
A + ++D GG W
Sbjct: 1356 AEINGEVDD-DDAGGEW 1371
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 60.5 bits (145), Expect = 3e-09
Identities = 82/350 (23%), Positives = 141/350 (40%), Gaps = 35/350 (10%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 935 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 983
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 984 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1039 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1096
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1097 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
EL+D + Q+ L ++E EV + ++L E Q+ +R
Sbjct: 1153 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/369 (20%), Positives = 151/369 (40%), Gaps = 51/369 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1494 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1605
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1606 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 361 EKAGLLKQL 369
EK K L
Sbjct: 1836 EKQAATKSL 1844
Score = 47.8 bits (112), Expect = 2e-05
Identities = 66/309 (21%), Positives = 125/309 (40%), Gaps = 40/309 (12%)
Query: 71 ARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGE 130
A K +++L ++ ELED + D + F T +N +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRD---------EIFATA------KENEKKAKSLEA 1687
Query: 131 QVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL-QLKKE 189
+ Q E+ R + D+ ++E A+ L L + L+DE + + QL++E
Sbjct: 1688 DLMQLQEDLAAAERARKQ-ADLEKEELAE--ELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
N E R+ Q+A + NEL A +R A +E + E ++++S+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNEL--ATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 250 QFLLKDTERFQARSQELEQKLLCKEQELEQ-----------LTQKQKRL-------EGQC 291
+ +F++ LE K+ E+++EQ L QK K+L E +
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
K + + N ++K ++L E E S + +++L+ EA + ++ EV
Sbjct: 1863 KMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Query: 352 YRVTESLQR 360
+ L+R
Sbjct: 1922 NALKSKLRR 1930
Score = 45.4 bits (106), Expect = 9e-05
Identities = 62/280 (22%), Positives = 124/280 (44%), Gaps = 50/280 (17%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1142
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1143 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 292 TALH---HDKHETKAE-NTKL-KLTNQ----------------ELARELERTSWELQDAQ 330
L D +AE N K+ KL N+ +LA+++ S +LQD Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
E LQ+E +++ V L+ E+ L QLD
Sbjct: 1322 ---ELLQEET-----RQKLNVSTKLRQLEEERNSLQDQLD 1353
Score = 44.7 bits (104), Expect = 1e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1340 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/128 (26%), Positives = 60/128 (46%), Gaps = 3/128 (2%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK-EMEVYRVTESLQ 359
+ +L QEL L L++ + + + LQ E K+ Q+ ++E E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 360 REKAGLLK 367
R+K L K
Sbjct: 966 RQKLQLEK 973
Score = 38.5 bits (88), Expect = 0.011
Identities = 68/322 (21%), Positives = 130/322 (40%), Gaps = 36/322 (11%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1350
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1408
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1409 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1466 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1578
Query: 348 EMEVYRVTESLQREKAGLLKQL 369
+++ E + ++ L +QL
Sbjct: 1579 DLQAR--DEQNEEKRRQLQRQL 1598
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 60.5 bits (145), Expect = 3e-09
Identities = 82/350 (23%), Positives = 141/350 (40%), Gaps = 35/350 (10%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 942 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 990
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 991 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1046 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1103
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1104 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
EL+D + Q+ L ++E EV + ++L E Q+ +R
Sbjct: 1160 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/369 (20%), Positives = 151/369 (40%), Gaps = 51/369 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1501 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1612
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1613 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 361 EKAGLLKQL 369
EK K L
Sbjct: 1843 EKQAATKSL 1851
Score = 47.8 bits (112), Expect = 2e-05
Identities = 66/309 (21%), Positives = 125/309 (40%), Gaps = 40/309 (12%)
Query: 71 ARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGE 130
A K +++L ++ ELED + D + F T +N +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRD---------EIFATA------KENEKKAKSLEA 1694
Query: 131 QVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL-QLKKE 189
+ Q E+ R + D+ ++E A+ L L + L+DE + + QL++E
Sbjct: 1695 DLMQLQEDLAAAERARKQ-ADLEKEELAE--ELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
N E R+ Q+A + NEL A +R A +E + E ++++S+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNEL--ATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 250 QFLLKDTERFQARSQELEQKLLCKEQELEQ-----------LTQKQKRL-------EGQC 291
+ +F++ LE K+ E+++EQ L QK K+L E +
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
K + + N ++K ++L E E S + +++L+ EA + ++ EV
Sbjct: 1870 KMAEQYKEQAEKGNARVKQLKRQL-EEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Query: 352 YRVTESLQR 360
+ L+R
Sbjct: 1929 NALKSKLRR 1937
Score = 45.4 bits (106), Expect = 9e-05
Identities = 62/280 (22%), Positives = 124/280 (44%), Gaps = 50/280 (17%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1149
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1150 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 292 TALH---HDKHETKAE-NTKL-KLTNQ----------------ELARELERTSWELQDAQ 330
L D +AE N K+ KL N+ +LA+++ S +LQD Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
E LQ+E +++ V L+ E+ L QLD
Sbjct: 1329 ---ELLQEET-----RQKLNVSTKLRQLEEERNSLQDQLD 1360
Score = 44.7 bits (104), Expect = 1e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1347 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/128 (26%), Positives = 60/128 (46%), Gaps = 3/128 (2%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK-EMEVYRVTESLQ 359
+ +L QEL L L++ + + + LQ E K+ Q+ ++E E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 360 REKAGLLK 367
R+K L K
Sbjct: 973 RQKLQLEK 980
Score = 38.5 bits (88), Expect = 0.011
Identities = 68/322 (21%), Positives = 130/322 (40%), Gaps = 36/322 (11%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1357
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1415
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1416 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1473 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1585
Query: 348 EMEVYRVTESLQREKAGLLKQL 369
+++ E + ++ L +QL
Sbjct: 1586 DLQAR--DEQNEEKRRQLQRQL 1605
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 60.5 bits (145), Expect = 3e-09
Identities = 82/350 (23%), Positives = 141/350 (40%), Gaps = 35/350 (10%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 882 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 941
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 942 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 990
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 991 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1045
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1046 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1103
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1104 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
EL+D + Q+ L ++E EV + ++L E Q+ +R
Sbjct: 1160 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/369 (20%), Positives = 151/369 (40%), Gaps = 51/369 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1501 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1558
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1559 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1612
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1613 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1663 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1722
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1723 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1782
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1783 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 361 EKAGLLKQL 369
EK K L
Sbjct: 1843 EKQAATKSL 1851
Score = 47.4 bits (111), Expect = 2e-05
Identities = 65/311 (20%), Positives = 131/311 (42%), Gaps = 37/311 (11%)
Query: 71 ARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGE 130
A K +++L ++ ELED + D + F T +N +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRD---------EIFATA------KENEKKAKSLEA 1694
Query: 131 QVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL-QLKKE 189
+ Q E+ R + D+ ++E A+ L L + L+DE + + QL++E
Sbjct: 1695 DLMQLQEDLAAAERARKQ-ADLEKEELAE--ELASSLSGRNALQDEKRRLEARIAQLEEE 1751
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
N E R+ Q+A + NEL A +R A +E + E ++++S+
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNEL--ATERSTAQKNESARQQLERQNKELRSKLH 1809
Query: 250 QFLLKDTERFQARSQELEQKLLCKEQELEQ-----------LTQKQKRLEGQCTALHHDK 298
+ +F++ LE K+ E+++EQ L QK K+L+ + ++
Sbjct: 1810 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1869
Query: 299 HETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESL 358
+ + + N + ++L+R +L++A+++ + + KL +E + E E++
Sbjct: 1870 KMAEQYKEQAEKGNARV-KQLKR---QLEEAEEESQRINANRRKLQRELD-EATESNEAM 1924
Query: 359 QREKAGLLKQL 369
RE L +L
Sbjct: 1925 GREVNALKSKL 1935
Score = 45.4 bits (106), Expect = 9e-05
Identities = 62/280 (22%), Positives = 124/280 (44%), Gaps = 50/280 (17%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1149
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1150 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268
Query: 292 TALH---HDKHETKAE-NTKL-KLTNQ----------------ELARELERTSWELQDAQ 330
L D +AE N K+ KL N+ +LA+++ S +LQD Q
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
E LQ+E +++ V L+ E+ L QLD
Sbjct: 1329 ---ELLQEET-----RQKLNVSTKLRQLEEERNSLQDQLD 1360
Score = 44.7 bits (104), Expect = 1e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1347 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/128 (26%), Positives = 60/128 (46%), Gaps = 3/128 (2%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK-EMEVYRVTESLQ 359
+ +L QEL L L++ + + + LQ E K+ Q+ ++E E
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 360 REKAGLLK 367
R+K L K
Sbjct: 973 RQKLQLEK 980
Score = 38.5 bits (88), Expect = 0.011
Identities = 68/322 (21%), Positives = 130/322 (40%), Gaps = 36/322 (11%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1357
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1415
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1416 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1473 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1585
Query: 348 EMEVYRVTESLQREKAGLLKQL 369
+++ E + ++ L +QL
Sbjct: 1586 DLQAR--DEQNEEKRRQLQRQL 1605
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 60.5 bits (145), Expect = 3e-09
Identities = 82/350 (23%), Positives = 141/350 (40%), Gaps = 35/350 (10%)
Query: 33 LDSLEQKETQEQTSGQLVM--LRKAQEFFQTCDAEGKGFIARK-DMQRLHKELPLSLEEL 89
L LEQK +Q L+ L+ E + + A+K +++ + E+ LEE
Sbjct: 875 LKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEE 934
Query: 90 EDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDL 149
ED L A+ + +E+A Q Q EKV + L
Sbjct: 935 EDRGQQLQAERKKMA---------QQMLDLEEQLEEEEAARQKLQL--EKVTAEAKIKKL 983
Query: 150 GDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPH------LLSNFEDFLTR 203
EDE ++L ++ L +E + L L +EE L + E ++
Sbjct: 984 ----EDEILVMDDQNNKLSKERKLLEER-ISDLTTNLAEEEEKAKNLTKLKNKHESMISE 1038
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ +L++ + + ELE LKRK+ + +++ QI K Q L K E QA
Sbjct: 1039 LEVRLKKEEKSRQELE-KLKRKLEGDASDFHEQIADLQAQIAELKMQ-LAKKEEELQAAL 1096
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
L+ ++ K L+++ + LEG + L D +A K + ++L ELE
Sbjct: 1097 ARLDDEIAQKNNALKKI----RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 324 WELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLR 373
EL+D + Q+ L ++E EV + ++L E Q+ +R
Sbjct: 1153 TELEDTLDSTATQQE----LRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Score = 51.2 bits (121), Expect = 2e-06
Identities = 76/369 (20%), Positives = 151/369 (40%), Gaps = 51/369 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
++LE KE E+T+ L + ++ + D GK +++ ++ +E+ LEEL
Sbjct: 1494 EALEAKEELERTNKMLKA--EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEEL 1551
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F +++ ++E + Q HE + L
Sbjct: 1552 EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL------ 1605
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q + A+K LE D+K L LQ ++E L + +
Sbjct: 1606 -----EDERKQRALAA---AAKKKLE--GDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQF-- 251
+L++A ++E+ K +K + + ++ L E++ +Q EKE+
Sbjct: 1656 DFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAE 1715
Query: 252 -----------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L + R +AR +LE++L ++ +E ++ + ++ Q L ++
Sbjct: 1716 ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELAT 1775
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +L + + ++S + + K ++ E R
Sbjct: 1776 ERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 361 EKAGLLKQL 369
EK K L
Sbjct: 1836 EKQAATKSL 1844
Score = 47.4 bits (111), Expect = 2e-05
Identities = 65/311 (20%), Positives = 131/311 (42%), Gaps = 37/311 (11%)
Query: 71 ARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGE 130
A K +++L ++ ELED + D + F T +N +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRD---------EIFATA------KENEKKAKSLEA 1687
Query: 131 QVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL-QLKKE 189
+ Q E+ R + D+ ++E A+ L L + L+DE + + QL++E
Sbjct: 1688 DLMQLQEDLAAAERARKQ-ADLEKEELAE--ELASSLSGRNALQDEKRRLEARIAQLEEE 1744
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
N E R+ Q+A + NEL A +R A +E + E ++++S+
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNEL--ATERSTAQKNESARQQLERQNKELRSKLH 1802
Query: 250 QFLLKDTERFQARSQELEQKLLCKEQELEQ-----------LTQKQKRLEGQCTALHHDK 298
+ +F++ LE K+ E+++EQ L QK K+L+ + ++
Sbjct: 1803 EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER 1862
Query: 299 HETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESL 358
+ + + N + ++L+R +L++A+++ + + KL +E + E E++
Sbjct: 1863 KMAEQYKEQAEKGNARV-KQLKR---QLEEAEEESQRINANRRKLQRELD-EATESNEAM 1917
Query: 359 QREKAGLLKQL 369
RE L +L
Sbjct: 1918 GREVNALKSKL 1928
Score = 45.4 bits (106), Expect = 9e-05
Identities = 62/280 (22%), Positives = 124/280 (44%), Gaps = 50/280 (17%)
Query: 131 QVAQRHEE-KVYLSRGDEDLGDMGE------DEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
Q+A++ EE + L+R D+++ + E L + L +++ ++++ ++
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKR- 1142
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQ---EAHEEKNELECALKRKIAAYDEEIQHLYEEM 240
L +E L + ED L +Q + + +E L+ AL + +++ ++Q + ++
Sbjct: 1143 -DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 241 EQQIKSEKEQF---------LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQC 291
Q ++ EQ L K+ + + + +L +L Q +++ K+K+LE Q
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261
Query: 292 TALH---HDKHETKAE-NTKL-KLTNQ----------------ELARELERTSWELQDAQ 330
L D +AE N K+ KL N+ +LA+++ S +LQD Q
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
E LQ+E +++ V L+ E+ L QLD
Sbjct: 1322 ---ELLQEET-----RQKLNVSTKLRQLEEERNSLQDQLD 1353
Score = 44.7 bits (104), Expect = 1e-04
Identities = 39/178 (21%), Positives = 85/178 (47%), Gaps = 6/178 (3%)
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE---EKNELECALKRKIA 227
KV + +++V+ + L + E + +D + + SQLQ+ E E+ + + K+
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKD-VASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
+EE L +++++++ E +Q L + + + ++KL +E L + +KR
Sbjct: 1340 QLEEERNSLQDQLDEEM--EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ 345
+ + L E A KL+ T L +EL+ +L + +Q + +L+++ K Q
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Score = 41.6 bits (96), Expect = 0.001
Identities = 34/128 (26%), Positives = 60/128 (46%), Gaps = 3/128 (2%)
Query: 243 QIKSEKEQFLLKDTE--RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
Q+ ++E+ K+ E + + R Q+ E +L EQ+ QLT+++ L+ Q A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK-EMEVYRVTESLQ 359
+ +L QEL L L++ + + + LQ E K+ Q+ ++E E
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 360 REKAGLLK 367
R+K L K
Sbjct: 966 RQKLQLEK 973
Score = 38.5 bits (88), Expect = 0.011
Identities = 68/322 (21%), Positives = 130/322 (40%), Gaps = 36/322 (11%)
Query: 63 DAEGKGFIARKDMQRLHKELPLSLEEL-EDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
+AEGK KD+ L +L + E L E+ L+ +E + Q+
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS-------LQD 1350
Query: 122 NPSQEDAGEQVAQRHEE--KVYLSRGDEDLGDMGEDEEA------QFRMLMDRLGAQKVL 173
+E +Q +RH + LS + L D EA +F+ ++ L Q
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQY-- 1408
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLT------RIISQLQEAHEEKNELECALKRKIA 227
+ + +L+K + L +D + +++S L++ + ++L K +
Sbjct: 1409 ---EEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y +E E E + K K L + E +ELE+ + E+E L + +
Sbjct: 1466 KYADERDRA--EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
L K + + ++K +EL EL+ T +DA+ +LE + +A K E+
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQAT----EDAKLRLE-VNMQALKGQFER 1578
Query: 348 EMEVYRVTESLQREKAGLLKQL 369
+++ E + ++ L +QL
Sbjct: 1579 DLQAR--DEQNEEKRRQLQRQL 1598
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 59.7 bits (143), Expect = 4e-09
Identities = 78/347 (22%), Positives = 152/347 (43%), Gaps = 30/347 (8%)
Query: 33 LDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLH-KELPLSLEELED 91
+ ++E+ +E+ S Q + R QE + IA+ +Q+LH KEL +EL
Sbjct: 441 IKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAK--LQKLHEKELARKEQELTK 498
Query: 92 VFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGD 151
+ + + + + SQ QE + + ++K L+ + L D
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL-QKKAILTESENKLRD 557
Query: 152 MGEDEEA-QFRMLMDRLGAQKVL-EDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQ 209
+ ++ E + R+L +K L E+++ K L + L+ E+ + ++ +
Sbjct: 558 LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKN---KHNKEITVMVEKHKT 614
Query: 210 EAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTER-FQARSQELEQ 268
E K++ + K+ ++ Q E++ ++ + EKE LLKD E FQA +E+ +
Sbjct: 615 ELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKET-LLKDKEIIFQAHIEEMNE 673
Query: 269 KLLCKEQELEQLTQKQKRLEGQCTALHH---DKHETKAENTKLKLTNQELARELERTSWE 325
K LE+L KQ LE + L +H+ + E + LK ++ +ELE
Sbjct: 674 K------TLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE----- 722
Query: 326 LQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
+Q QQ+ + +E E+ + R ++L+ + + QL+ L
Sbjct: 723 -AKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ----INQLELL 764
Score = 55.5 bits (132), Expect = 8e-08
Identities = 50/211 (23%), Positives = 103/211 (48%), Gaps = 12/211 (5%)
Query: 170 QKVLEDESD----VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRK 225
QK+L+ E++ KQ+ +++ ++ + + + ++ +Q+ ++ +E+E +K
Sbjct: 826 QKLLDLETERILLTKQV-AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL 884
Query: 226 IAAYDEEIQHLYEEMEQ--QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQK 283
Y+ +++ +E EQ QI EKE +L+ E + + L QKL KE + L ++
Sbjct: 885 TQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEE 944
Query: 284 -QKRLEGQCTALHHDKHETK--AENTKLKLTNQE--LARELERTSWELQDAQQQLESLQQ 338
+ + + Q + K + K E K KL +QE L +ELE T+ EL ++Q +
Sbjct: 945 YETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKML 1004
Query: 339 EACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
E + + + E+ Q+E+ L ++
Sbjct: 1005 EMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
Score = 54.7 bits (130), Expect = 1e-07
Identities = 48/186 (25%), Positives = 94/186 (50%), Gaps = 23/186 (12%)
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHE----EKNELECALKRKIAAYDEEIQHLYEEMEQ 242
++E ++S +E L + +LQE HE EK + LK+KI + E EEM +
Sbjct: 1037 RRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCE----KEEMNK 1092
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
+I KE+ + +DT EL+++L K + L Q + +L+ L D +++
Sbjct: 1093 EITWLKEEGVKQDTTL-----NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 303 AENT-------KLKLTNQELARELERTSWELQDAQQQLESLQ---QEACKLHQEKEMEVY 352
ENT +LK+ +E R++ + +L+ ++ +SL+ +++ K ++K +E
Sbjct: 1148 KENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFK 1207
Query: 353 RVTESL 358
+++E L
Sbjct: 1208 KLSEEL 1213
Score = 49.3 bits (116), Expect = 6e-06
Identities = 54/184 (29%), Positives = 83/184 (45%), Gaps = 27/184 (14%)
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNEL---------ECALKRKIAAYDEEI--QHLYE 238
+P LLSN E + +L A EK +L + + RK + EI + +
Sbjct: 1914 QPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ 1973
Query: 239 EMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQK--QKRLEGQCTALHH 296
E E++IK E+E LK + +E +L KEQELE ++ K E + L
Sbjct: 1974 EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033
Query: 297 DKHETKAENTKLKLTNQEL------------ARELERTSWELQDAQQQLESLQQE-ACKL 343
+ ET K+ + +L ARE E T+ +++D Q QLE LQ++ KL
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA-KVRDLQTQLEELQKKYQQKL 2092
Query: 344 HQEK 347
QE+
Sbjct: 2093 EQEE 2096
Score = 46.6 bits (109), Expect = 4e-05
Identities = 44/176 (25%), Positives = 82/176 (46%), Gaps = 16/176 (9%)
Query: 201 LTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE--QFLLKDTER 258
++ + +QL++ EE+N L + ++ H EE E QIKS K + L+ + E
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISF--------QQATHQLEEKENQIKSMKADIESLVTEKEA 1322
Query: 259 FQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARE 318
Q +Q KE + QL ++ T + + E K E + L +L +
Sbjct: 1323 LQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 319 LERTSWELQDAQQQLESLQ----QEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
L+ S L + + + SL+ +E C+L + + ++V ++L +EK L+Q+D
Sbjct: 1383 LQ-NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV-DTLSKEKISALEQVD 1436
Score = 44.7 bits (104), Expect = 1e-04
Identities = 71/364 (19%), Positives = 153/364 (42%), Gaps = 62/364 (17%)
Query: 17 QGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQ 76
+ G+ G + L++L+Q+ +++ +L++ +E Q+ + + K+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQEN-----LLKRCKETIQSHKEQCTLLTSEKEA- 318
Query: 77 RLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRH 136
L ++L L+ELE + D A+ +T ++D G +A+
Sbjct: 319 -LQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL-------EQDKGMVIAETK 370
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSN 196
+ + +M E+E AQ R + ++ Q ++L Q +K E +
Sbjct: 371 RQM-------HETLEMKEEEIAQLRSRIKQMTTQG--------EELREQKEKSER---AA 412
Query: 197 FEDFLTRIISQLQEAHEEKNELECALKRKIAAYD-----------EEIQHLYEEMEQQIK 245
FE+ L + +S Q+ E + +L+ + +I + +E+ + +E+ +K
Sbjct: 413 FEE-LEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMK 471
Query: 246 SEKEQFLLK----DTERFQARSQELEQKLLCKEQEL-EQLTQKQKRLEGQCTALHHDKHE 300
E+ + K + + QEL +KL +E+E EQ+ ++ + + + +K +
Sbjct: 472 KSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQ 531
Query: 301 TKAENTKLKLTNQELARE--LERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESL 358
++ L L EL ++ L + +L+D QQ+ E+ + +L E +SL
Sbjct: 532 QES----LALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLE-------KSL 580
Query: 359 QREK 362
Q K
Sbjct: 581 QENK 584
Score = 43.5 bits (101), Expect = 3e-04
Identities = 60/245 (24%), Positives = 99/245 (40%), Gaps = 31/245 (12%)
Query: 155 DEEAQFRMLMDRLGAQKV--LEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQ--- 209
D+ +D L +K+ LE D + + KK+ + ++ + + QL+
Sbjct: 1412 DQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKS 1471
Query: 210 -EAHEEKNELECALKRKIAAYDEEIQHLYEEMEQ-QIKSEKEQFLLKDTERFQ-ARSQEL 266
EA+E+ ++ LK ++ ++ L EME + K EK++ L+ + Q AR EL
Sbjct: 1472 KEAYEKDEQINL-LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
Query: 267 EQKLLCKEQELEQLTQKQKRLEGQCTALH----------------HDKHETKAENTKLKL 310
E + K E+E L + K Q H D +AE L L
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTL 1590
Query: 311 TNQ--ELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK----AG 364
NQ + ELE EL+ ++S ++E L E E L+R+ A
Sbjct: 1591 ENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAA 1650
Query: 365 LLKQL 369
+ KQL
Sbjct: 1651 IKKQL 1655
Score = 41.6 bits (96), Expect = 0.001
Identities = 61/270 (22%), Positives = 115/270 (42%), Gaps = 42/270 (15%)
Query: 133 AQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLM----------DRLGAQKVLEDESDVKQL 182
A++HE++ + E+L E++ ++ +++ + + A++ LE+ D Q
Sbjct: 1785 AKQHEDQSMIGHLQEEL----EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840
Query: 183 WLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDE------EIQHL 236
LQ K+ +L L + + +E H + E + K+ A + + L
Sbjct: 1841 TLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELL 1900
Query: 237 YEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
E E++ KS Q L +A+ +LE KL E+E ++L ++ RL+ L
Sbjct: 1901 EENTEEKSKSHLVQPKL--LSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRK 1958
Query: 297 D----------------KHETKAENTKLKLTNQELARELERT-SWELQDAQQQLESLQQE 339
+ + + K E L+L + ++L R + +L +Q+LE +E
Sbjct: 1959 EHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018
Query: 340 ACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
QE E E + ES Q E LLK++
Sbjct: 2019 TINKAQEVEAE---LLESHQEETNQLLKKI 2045
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/224 (23%), Positives = 98/224 (43%), Gaps = 27/224 (12%)
Query: 172 VLEDESDVKQLWLQLKKEEP--HLLSNFEDFLTRIISQLQEAH----EEKNELECALKRK 225
VL+D++D + L+ K +E H + + +Q ++ N+LE LK +
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 226 IAAYDEEIQHLYEEMEQQIK-SEKE-QFLLKDTERFQARSQELEQKLLCKEQELEQLTQK 283
E H+ E +E IK SE E Q + FQ+ ++ E++L QL QK
Sbjct: 769 DKHLKEHQAHV-ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 284 QKRLEGQCTALHHDKHETKAENTKL-------KLTNQELARELERTSWELQDAQQQLESL 336
LE + L E +A+ + K+ Q+L ++LE+ + E++ + L +
Sbjct: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQV 887
Query: 337 -----------QQEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
Q++ ++ EKE + ++ E ++E L ++L
Sbjct: 888 YESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL 931
Score = 40.8 bits (94), Expect = 0.002
Identities = 57/252 (22%), Positives = 109/252 (43%), Gaps = 21/252 (8%)
Query: 122 NPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQ 181
N ++ +Q H+E V + ++LG+ ++ + +K+L E+ V
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKE--------AEEKILTLENQVYS 1596
Query: 182 LWLQL---KKEEPHL---LSNFEDFLTRIISQLQ-EAHEEKNELECALKRKIAAYDEEIQ 234
+ +L KKE H+ + + E+ L + +L+ E+ + EL+ ++KIAA +++
Sbjct: 1597 MKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLL 1656
Query: 235 HLYEEMEQQIKSEKEQFLLKDTERFQARSQE---LEQKLLCKEQELEQLTQKQKRLEGQC 291
EE E+Q K E L + + Q R +E LE+KL K E Q +
Sbjct: 1657 SQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKL--KSVESSQSETLIVPRSAKN 1714
Query: 292 TALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
A + ++ E ++ K T +E L+R E + Q++ ++E H E +
Sbjct: 1715 VAAYTEQEEADSQGCVQK-TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQY 1773
Query: 352 YRVTESLQREKA 363
L+ +A
Sbjct: 1774 QERLIKLEHAEA 1785
Score = 39.7 bits (91), Expect = 0.005
Identities = 59/288 (20%), Positives = 124/288 (43%), Gaps = 42/288 (14%)
Query: 87 EELEDVFDALDADGNG-YLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRG 145
+E+E + L A + ++ +E+ T F + QE E+V Q+ +E
Sbjct: 922 KEIEILTQKLSAKEDSIHILNEEYETKFKN---------QEKKMEKVKQKAKEM------ 966
Query: 146 DEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEP----HLLSNFEDFL 201
E L D+EA+ + ++ A ++ + E L++ + +S E
Sbjct: 967 QETLKKKLLDQEAKLKKELENT-ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQ 1025
Query: 202 TRIISQLQEAHE-EKNELECALKRKIAAYDEEIQHLYE----EMEQQIKSEKEQFLLKDT 256
I L E H E N++ ++K+ EE+Q ++E E EQ++ K++ LL
Sbjct: 1026 KEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGC 1085
Query: 257 ERFQARSQE--LEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQE 314
E+ + + L+++ + ++ L +L ++ K+ +L D+ + KA KL++
Sbjct: 1086 EKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEV---- 1141
Query: 315 LARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREK 362
+L + ++ LQ++ +L E + +V+E + K
Sbjct: 1142 ----------DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLK 1179
Score = 37.4 bits (85), Expect = 0.024
Identities = 32/171 (18%), Positives = 85/171 (49%), Gaps = 12/171 (7%)
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+ Q+ E +K ++ C ++ A+ ++Q L +++E+Q SE EQ + T+ ++++
Sbjct: 838 LTKQVAEVEAQKKDV-CT---ELDAHKIQVQDLMQQLEKQ-NSEMEQKVKSLTQVYESKL 892
Query: 264 QELEQKLLCKEQELEQLTQKQKRL----EGQCTALHHDKHETKAENTKLKLTNQELAREL 319
++ ++ +EQ + L +K+ + EGQ + + A+ + + N+E +
Sbjct: 893 EDGNKE---QEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKF 949
Query: 320 ERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
+ +++ +Q+ + +Q+ K ++E ++ + E+ E + KQ +
Sbjct: 950 KNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN 1000
Score = 36.6 bits (83), Expect = 0.041
Identities = 41/237 (17%), Positives = 101/237 (42%), Gaps = 18/237 (7%)
Query: 146 DEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRII 205
+E L + + ++ + + L+ +L + L +E D + +K+ E +L+ ++
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR-----VKEAEEKILT----LENQVY 1595
Query: 206 SQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQE 265
S E +K ELE + + + +EE++ L + +E + ++ + K ++ A ++
Sbjct: 1596 SMKAELETKKKELE-HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQ 1654
Query: 266 LEQKLLCKEQE--------LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAR 317
L ++ KE++ L +L K + E + L ++ ++ + +
Sbjct: 1655 LLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKN 1714
Query: 318 ELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRC 374
T E D+Q ++ +E + Q E ++ + + +EK + +RC
Sbjct: 1715 VAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRC 1771
Score = 36.2 bits (82), Expect = 0.053
Identities = 59/263 (22%), Positives = 105/263 (39%), Gaps = 71/263 (26%)
Query: 175 DESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALK-------RKIA 227
D + +QL +L++ E LS++ + +++ Q EK +L+ L R+IA
Sbjct: 132 DSLNKEQLIQRLRRME-RSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIA 190
Query: 228 AYDEEIQ-------HLYEEMEQQIKSEKEQFLLKDTERFQARSQEL-------------- 266
EE+Q HL EE + ++ EK+Q++ + Q L
Sbjct: 191 ELREELQMDQQAKKHLQEEFDASLE-EKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLP 249
Query: 267 ----EQKLLCKEQE-----------------LEQLTQKQKRLEG--------------QC 291
+ ++ KE+ LE L Q+ KR E QC
Sbjct: 250 QLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQC 309
Query: 292 TALHHDKHETKAENTKLKLTNQELAREL---ERTSW--ELQDAQQQLESLQQEACKLHQE 346
T L +K E E +L E ++L E+T +L+DA+ +E L+Q+ + E
Sbjct: 310 TLLTSEK-EALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAE 368
Query: 347 KEMEVYRVTESLQREKAGLLKQL 369
+ +++ E + E A L ++
Sbjct: 369 TKRQMHETLEMKEEEIAQLRSRI 391
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 59.3 bits (142), Expect = 6e-09
Identities = 48/177 (27%), Positives = 90/177 (50%), Gaps = 23/177 (12%)
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME------QQIKSEKEQFLLKD--- 255
I+QL+E +EKN+ +LK+ + +E I L +++E Q ++ EKE + ++
Sbjct: 168 IAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 224
Query: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
E A Q L+QK + ++QE E+L QK+ +++ + L +K + + + KL +E+
Sbjct: 225 NENLNAEMQNLKQKFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEEM 281
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
+E EL+ +L+ LQQ KE + R+ + L+ E ++L L
Sbjct: 282 VKEKNLFEEELKQTLDELDKLQQ--------KEEQAERLVKQLEEEAKSRAEELKLL 330
Score = 39.7 bits (91), Expect = 0.005
Identities = 47/218 (21%), Positives = 93/218 (42%), Gaps = 26/218 (11%)
Query: 161 RMLMDRLGAQ----KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE--E 214
R+L+ GAQ + LE E + + L E LS L + + +L +E +
Sbjct: 6 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLK 65
Query: 215 KNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKE 274
E ++ + E+ L + E +++ A+ + +E KL +
Sbjct: 66 SKFSENGNQKNLRILSLELMKLRNKRETKMRG------------MMAKQEGMEMKLQVTQ 113
Query: 275 QELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLE 334
+ LE+ K +LEG+ ++ +K + K+E KL E E+ S +++ + +
Sbjct: 114 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL----LEYIEEISCASDQVEKYKLDIA 169
Query: 335 SLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
L++ +EK E+ + +SL+ L KQ++ L
Sbjct: 170 QLEENL----KEKNDEILSLKQSLEENIVILSKQVEDL 203
Score = 38.9 bits (89), Expect = 0.008
Identities = 71/320 (22%), Positives = 123/320 (38%), Gaps = 28/320 (8%)
Query: 30 LHPLDSLEQKETQ-EQTSGQLVMLRKAQ-EFFQTCDAEGKGFIARKDMQRL-HKELPLSL 86
L LD L+QKE Q E+ QL K++ E + + + KG A + H + L L
Sbjct: 296 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 355
Query: 87 EELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGD 146
+E D D + T N S ++ + + E+ +
Sbjct: 356 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 415
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
E + RML+D L + L+ E+++K++ + ++ L + +
Sbjct: 416 ES------SNQEYVRMLLD-LQTKSALK-ETEIKEITVSFLQKITDLQNQLKQQEEDFRK 467
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQH---LYEEMEQQIKSEKEQFLLKDTERFQARS 263
QL++ K E E A EEI LYEE+ + K + Q + F+
Sbjct: 468 QLEDEEGRKAEKE----NTTAELTEEINKWRLLYEELYNKTKPFQLQL-----DAFEVEK 518
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
Q L + +++L ++ +L G KH K LK N +L E+ +
Sbjct: 519 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK-----LKDENSQLKSEVSKLR 573
Query: 324 WELQDAQQQLESLQQEACKL 343
+L +Q LQ+E K+
Sbjct: 574 CQLAKKKQSETKLQEELNKV 593
Score = 37.4 bits (85), Expect = 0.024
Identities = 60/290 (20%), Positives = 125/290 (43%), Gaps = 56/290 (19%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
S E++ ++AQ + V + + E + + E E+ + + +V + + D+ QL
Sbjct: 115 SLEESQGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 172
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQ 243
LK++ +LS + I+ ++ + + + K K + +H E + +
Sbjct: 173 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH-NENLNAE 231
Query: 244 IKSEKEQFLLKDTERFQARSQELE----------------------QKLLCKEQ------ 275
+++ K++F+L+ ER + + +EL+ Q+ + KE+
Sbjct: 232 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 291
Query: 276 ------ELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL---ARELERTSWEL 326
EL++L QK+++ E L + E K+ +LKL ++L ELE++S
Sbjct: 292 LKQTLDELDKLQQKEEQAERLVKQL---EEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 348
Query: 327 QDA----QQQLESLQQ---------EACKLHQEKEMEVYRVTESLQREKA 363
A Q++ +S+ Q E+ K E+E ++ S +EKA
Sbjct: 349 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 398
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 59.3 bits (142), Expect = 6e-09
Identities = 48/177 (27%), Positives = 90/177 (50%), Gaps = 23/177 (12%)
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME------QQIKSEKEQFLLKD--- 255
I+QL+E +EKN+ +LK+ + +E I L +++E Q ++ EKE + ++
Sbjct: 255 IAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 311
Query: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
E A Q L+QK + ++QE E+L QK+ +++ + L +K + + + KL +E+
Sbjct: 312 NENLNAEMQNLKQKFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEEM 368
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
+E EL+ +L+ LQQ KE + R+ + L+ E ++L L
Sbjct: 369 VKEKNLFEEELKQTLDELDKLQQ--------KEEQAERLVKQLEEEAKSRAEELKLL 417
Score = 44.3 bits (103), Expect = 2e-04
Identities = 54/251 (21%), Positives = 106/251 (42%), Gaps = 30/251 (11%)
Query: 128 AGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQ----KVLEDESDVKQLW 183
A + + E K + D+DL + E + R+L+ GAQ + LE E + +
Sbjct: 64 ASARKVKSSESKKESQKNDKDLKIL----EKEIRVLLQERGAQDRRIQDLETELEKMEAR 119
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQEAHE--EKNELECALKRKIAAYDEEIQHLYEEME 241
L E LS L + + +L +E + E ++ + E+ L + E
Sbjct: 120 LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 179
Query: 242 QQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHET 301
+++ A+ + +E KL ++ LE+ K +LEG+ ++ +K +
Sbjct: 180 TKMRG------------MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDE 227
Query: 302 KAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE 361
K+E KL E E+ S +++ + + L++ +EK E+ + +SL+
Sbjct: 228 KSETEKL----LEYIEEISCASDQVEKYKLDIAQLEENL----KEKNDEILSLKQSLEEN 279
Query: 362 KAGLLKQLDFL 372
L KQ++ L
Sbjct: 280 IVILSKQVEDL 290
Score = 38.9 bits (89), Expect = 0.008
Identities = 71/320 (22%), Positives = 123/320 (38%), Gaps = 28/320 (8%)
Query: 30 LHPLDSLEQKETQ-EQTSGQLVMLRKAQ-EFFQTCDAEGKGFIARKDMQRL-HKELPLSL 86
L LD L+QKE Q E+ QL K++ E + + + KG A + H + L L
Sbjct: 383 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
Query: 87 EELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGD 146
+E D D + T N S ++ + + E+ +
Sbjct: 443 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
E + RML+D L + L+ E+++K++ + ++ L + +
Sbjct: 503 ES------SNQEYVRMLLD-LQTKSALK-ETEIKEITVSFLQKITDLQNQLKQQEEDFRK 554
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQH---LYEEMEQQIKSEKEQFLLKDTERFQARS 263
QL++ K E E A EEI LYEE+ + K + Q + F+
Sbjct: 555 QLEDEEGRKAEKE----NTTAELTEEINKWRLLYEELYNKTKPFQLQL-----DAFEVEK 605
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
Q L + +++L ++ +L G KH K LK N +L E+ +
Sbjct: 606 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK-----LKDENSQLKSEVSKLR 660
Query: 324 WELQDAQQQLESLQQEACKL 343
+L +Q LQ+E K+
Sbjct: 661 CQLAKKKQSETKLQEELNKV 680
Score = 37.4 bits (85), Expect = 0.024
Identities = 60/290 (20%), Positives = 125/290 (43%), Gaps = 56/290 (19%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
S E++ ++AQ + V + + E + + E E+ + + +V + + D+ QL
Sbjct: 202 SLEESQGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 259
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQ 243
LK++ +LS + I+ ++ + + + K K + +H E + +
Sbjct: 260 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH-NENLNAE 318
Query: 244 IKSEKEQFLLKDTERFQARSQELE----------------------QKLLCKEQ------ 275
+++ K++F+L+ ER + + +EL+ Q+ + KE+
Sbjct: 319 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 378
Query: 276 ------ELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL---ARELERTSWEL 326
EL++L QK+++ E L + E K+ +LKL ++L ELE++S
Sbjct: 379 LKQTLDELDKLQQKEEQAERLVKQL---EEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
Query: 327 QDA----QQQLESLQQ---------EACKLHQEKEMEVYRVTESLQREKA 363
A Q++ +S+ Q E+ K E+E ++ S +EKA
Sbjct: 436 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 485
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 59.3 bits (142), Expect = 6e-09
Identities = 48/177 (27%), Positives = 90/177 (50%), Gaps = 23/177 (12%)
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME------QQIKSEKEQFLLKD--- 255
I+QL+E +EKN+ +LK+ + +E I L +++E Q ++ EKE + ++
Sbjct: 239 IAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 295
Query: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
E A Q L+QK + ++QE E+L QK+ +++ + L +K + + + KL +E+
Sbjct: 296 NENLNAEMQNLKQKFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEEM 352
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
+E EL+ +L+ LQQ KE + R+ + L+ E ++L L
Sbjct: 353 VKEKNLFEEELKQTLDELDKLQQ--------KEEQAERLVKQLEEEAKSRAEELKLL 401
Score = 43.9 bits (102), Expect = 3e-04
Identities = 46/218 (21%), Positives = 97/218 (44%), Gaps = 23/218 (10%)
Query: 169 AQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELEC---ALKRK 225
A+KV ES ++ L LQ + + + + E L ++ ++L A EK L L+++
Sbjct: 66 ARKVKSSESKIRVL-LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQ 124
Query: 226 IAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQ-----------ARSQELEQKLLCKE 274
+ + L + + + + L + + + A+ + +E KL +
Sbjct: 125 LIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 184
Query: 275 QELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLE 334
+ LE+ K +LEG+ ++ +K + K+E KL E E+ S +++ + +
Sbjct: 185 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL----LEYIEEISCASDQVEKYKLDIA 240
Query: 335 SLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
L++ +EK E+ + +SL+ L KQ++ L
Sbjct: 241 QLEENL----KEKNDEILSLKQSLEENIVILSKQVEDL 274
Score = 38.9 bits (89), Expect = 0.008
Identities = 71/320 (22%), Positives = 123/320 (38%), Gaps = 28/320 (8%)
Query: 30 LHPLDSLEQKETQ-EQTSGQLVMLRKAQ-EFFQTCDAEGKGFIARKDMQRL-HKELPLSL 86
L LD L+QKE Q E+ QL K++ E + + + KG A + H + L L
Sbjct: 367 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 426
Query: 87 EELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGD 146
+E D D + T N S ++ + + E+ +
Sbjct: 427 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 486
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
E + RML+D L + L+ E+++K++ + ++ L + +
Sbjct: 487 ES------SNQEYVRMLLD-LQTKSALK-ETEIKEITVSFLQKITDLQNQLKQQEEDFRK 538
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQH---LYEEMEQQIKSEKEQFLLKDTERFQARS 263
QL++ K E E A EEI LYEE+ + K + Q + F+
Sbjct: 539 QLEDEEGRKAEKE----NTTAELTEEINKWRLLYEELYNKTKPFQLQL-----DAFEVEK 589
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
Q L + +++L ++ +L G KH K LK N +L E+ +
Sbjct: 590 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK-----LKDENSQLKSEVSKLR 644
Query: 324 WELQDAQQQLESLQQEACKL 343
+L +Q LQ+E K+
Sbjct: 645 CQLAKKKQSETKLQEELNKV 664
Score = 37.4 bits (85), Expect = 0.024
Identities = 60/290 (20%), Positives = 125/290 (43%), Gaps = 56/290 (19%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
S E++ ++AQ + V + + E + + E E+ + + +V + + D+ QL
Sbjct: 186 SLEESQGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 243
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQ 243
LK++ +LS + I+ ++ + + + K K + +H E + +
Sbjct: 244 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH-NENLNAE 302
Query: 244 IKSEKEQFLLKDTERFQARSQELE----------------------QKLLCKEQ------ 275
+++ K++F+L+ ER + + +EL+ Q+ + KE+
Sbjct: 303 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 362
Query: 276 ------ELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL---ARELERTSWEL 326
EL++L QK+++ E L + E K+ +LKL ++L ELE++S
Sbjct: 363 LKQTLDELDKLQQKEEQAERLVKQL---EEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 419
Query: 327 QDA----QQQLESLQQ---------EACKLHQEKEMEVYRVTESLQREKA 363
A Q++ +S+ Q E+ K E+E ++ S +EKA
Sbjct: 420 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 469
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 59.3 bits (142), Expect = 6e-09
Identities = 48/177 (27%), Positives = 90/177 (50%), Gaps = 23/177 (12%)
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEME------QQIKSEKEQFLLKD--- 255
I+QL+E +EKN+ +LK+ + +E I L +++E Q ++ EKE + ++
Sbjct: 254 IAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH 310
Query: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL 315
E A Q L+QK + ++QE E+L QK+ +++ + L +K + + + KL +E+
Sbjct: 311 NENLNAEMQNLKQKFILEQQEREKLQQKELQID---SLLQQEKELSSSLHQKLCSFQEEM 367
Query: 316 ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
+E EL+ +L+ LQQ KE + R+ + L+ E ++L L
Sbjct: 368 VKEKNLFEEELKQTLDELDKLQQ--------KEEQAERLVKQLEEEAKSRAEELKLL 416
Score = 42.4 bits (98), Expect = 7e-04
Identities = 51/235 (21%), Positives = 101/235 (42%), Gaps = 30/235 (12%)
Query: 144 RGDEDLGDMGEDEEAQFRMLMDRLGAQ----KVLEDESDVKQLWLQLKKEEPHLLSNFED 199
+ D+DL + E + R+L+ GAQ + LE E + + L E LS
Sbjct: 79 KNDKDLKIL----EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNA 134
Query: 200 FLTRIISQLQEAHE--EKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTE 257
L + + +L +E + E ++ + E+ L + E +++
Sbjct: 135 TLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRG----------- 183
Query: 258 RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAR 317
A+ + +E KL ++ LE+ K +LEG+ ++ +K + K+E KL E
Sbjct: 184 -MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL----LEYIE 238
Query: 318 ELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
E+ S +++ + + L++ +EK E+ + +SL+ L KQ++ L
Sbjct: 239 EISCASDQVEKYKLDIAQLEENL----KEKNDEILSLKQSLEENIVILSKQVEDL 289
Score = 38.9 bits (89), Expect = 0.008
Identities = 71/320 (22%), Positives = 123/320 (38%), Gaps = 28/320 (8%)
Query: 30 LHPLDSLEQKETQ-EQTSGQLVMLRKAQ-EFFQTCDAEGKGFIARKDMQRL-HKELPLSL 86
L LD L+QKE Q E+ QL K++ E + + + KG A + H + L L
Sbjct: 382 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 441
Query: 87 EELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGD 146
+E D D + T N S ++ + + E+ +
Sbjct: 442 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 501
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
E + RML+D L + L+ E+++K++ + ++ L + +
Sbjct: 502 ES------SNQEYVRMLLD-LQTKSALK-ETEIKEITVSFLQKITDLQNQLKQQEEDFRK 553
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQH---LYEEMEQQIKSEKEQFLLKDTERFQARS 263
QL++ K E E A EEI LYEE+ + K + Q + F+
Sbjct: 554 QLEDEEGRKAEKE----NTTAELTEEINKWRLLYEELYNKTKPFQLQL-----DAFEVEK 604
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
Q L + +++L ++ +L G KH K LK N +L E+ +
Sbjct: 605 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVK-----LKDENSQLKSEVSKLR 659
Query: 324 WELQDAQQQLESLQQEACKL 343
+L +Q LQ+E K+
Sbjct: 660 CQLAKKKQSETKLQEELNKV 679
Score = 37.4 bits (85), Expect = 0.024
Identities = 60/290 (20%), Positives = 125/290 (43%), Gaps = 56/290 (19%)
Query: 124 SQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLW 183
S E++ ++AQ + V + + E + + E E+ + + +V + + D+ QL
Sbjct: 201 SLEESQGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 258
Query: 184 LQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQ 243
LK++ +LS + I+ ++ + + + K K + +H E + +
Sbjct: 259 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREH-NENLNAE 317
Query: 244 IKSEKEQFLLKDTERFQARSQELE----------------------QKLLCKEQ------ 275
+++ K++F+L+ ER + + +EL+ Q+ + KE+
Sbjct: 318 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEE 377
Query: 276 ------ELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQEL---ARELERTSWEL 326
EL++L QK+++ E L + E K+ +LKL ++L ELE++S
Sbjct: 378 LKQTLDELDKLQQKEEQAERLVKQL---EEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 434
Query: 327 QDA----QQQLESLQQ---------EACKLHQEKEMEVYRVTESLQREKA 363
A Q++ +S+ Q E+ K E+E ++ S +EKA
Sbjct: 435 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 484
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 59.3 bits (142), Expect = 6e-09
Identities = 59/242 (24%), Positives = 114/242 (47%), Gaps = 22/242 (9%)
Query: 151 DMGEDE----EAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
D GED E Q L ++L K ++ K++ L+ E LL + R+
Sbjct: 432 DQGEDLRHGLETQVMELQNKL---KHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEE 488
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE--QFLLKDTERFQARSQ 264
QL+ E L+ ALK ++A+ D+E++H+ ++ ++ + + Q +D +A Q
Sbjct: 489 QLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQ 548
Query: 265 ELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELAREL----E 320
++ + ++ELE+ +++ + D TK E +L++ +E+ EL E
Sbjct: 549 KMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIE 608
Query: 321 RTSWELQDAQ------QQLESLQQEACKLHQE-KEMEVYRVTESL--QREKAGLLKQLDF 371
EL+ A+ +Q+E L++E + +E KE++ R ++ + + L KQL
Sbjct: 609 VLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAV 668
Query: 372 LR 373
LR
Sbjct: 669 LR 670
Score = 48.9 bits (115), Expect = 8e-06
Identities = 77/358 (21%), Positives = 138/358 (38%), Gaps = 28/358 (7%)
Query: 37 EQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDAL 96
E +ET E+T M +K +E + E R + + + +EL +E L+ +
Sbjct: 560 ELEETSEETGHWQSMFQKNKEDLRATKQELLQL--RMEKEEMEEELGEKIEVLQRELEQA 617
Query: 97 DADGNG-----YLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGD 151
A L + T SQE AG + E+++ + R + D G
Sbjct: 618 RASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGR 677
Query: 152 MGEDEEAQFRMLMDRLG--------AQKVLEDESDVK-QLWLQLKKEEPHLLSNFEDFLT 202
E++ Q + + +L A+ V E E+ V Q ++ ++F
Sbjct: 678 ELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRR 737
Query: 203 RIISQLQEAHEEKN------ELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDT 256
RI+ Q+ E + +E L+ K+ + E Q L E + E+E L
Sbjct: 738 RILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNAS--QEEEGSLAAAK 795
Query: 257 ERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELA 316
+AR +E ++ L QE + L + + Q L K E + + L T L
Sbjct: 796 RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN 855
Query: 317 RELER----TSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
+ELE+ + LQ Q QLE +++A + + + + ++ GL + D
Sbjct: 856 KELEKIGEDSKQALQQLQAQLEDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQD 913
Score = 39.3 bits (90), Expect = 0.006
Identities = 39/139 (28%), Positives = 71/139 (51%), Gaps = 21/139 (15%)
Query: 157 EAQFRMLMDRLGAQK----VLED-----ESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS- 206
E+Q ++L +RL A++ VL+ E VK+L +Q++ E H+ + R+ +
Sbjct: 1051 ESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKAL 1110
Query: 207 --QLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS- 263
Q+ EA EE L+ L++K EE + E+++ +IKS L KD+ R +RS
Sbjct: 1111 KRQVDEAEEEIERLD-GLRKKAQREVEEQHEVNEQLQARIKS-----LEKDSWRKASRSA 1164
Query: 264 --QELEQKLLCKEQELEQL 280
L+ + L ++E + +
Sbjct: 1165 AESALKNEGLSSDEEFDSV 1183
Score = 36.2 bits (82), Expect = 0.053
Identities = 43/222 (19%), Positives = 102/222 (45%), Gaps = 18/222 (8%)
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNF----EDFLTRI 204
L + ++ E + R DR K LE++ + L +K LL++ D + ++
Sbjct: 943 LQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQL 1002
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI-KSEKEQFLLKDTERFQARS 263
++L + + +LEC KI+ ++ ++++ ++ SE Q + ++++
Sbjct: 1003 RTELMQERSARQDLECD---KIS-----LERQNKDLKTRLASSEGFQKPSASLSQLESQN 1054
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTAL----HHDKHETKAENTKLKLTNQELAREL 319
Q L+++L +E+E L ++LE + L ++ + +L L + L R++
Sbjct: 1055 QLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQV 1114
Query: 320 ERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQRE 361
+ E++ + Q+E + H+ E R+ +SL+++
Sbjct: 1115 DEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARI-KSLEKD 1155
Score = 30.4 bits (67), Expect = 2.9
Identities = 26/122 (21%), Positives = 58/122 (47%), Gaps = 13/122 (10%)
Query: 213 EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLC 272
E +E E +++RK++ E++Q L K+ Q EL +K+
Sbjct: 324 EGSSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQ-------------GELTRKVEE 370
Query: 273 KEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQ 332
+++L++ +K+++LE L E E ++L+ + E ++++ ELQ+ ++
Sbjct: 371 LQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430
Query: 333 LE 334
L+
Sbjct: 431 LD 432
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 58.2 bits (139), Expect = 1e-08
Identities = 63/264 (23%), Positives = 114/264 (43%), Gaps = 37/264 (14%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEA-----QFRMLMDRLGAQKVLEDESDVK 180
E+ E+ EK + + ++L + E+EE+ Q + +K+ E++ ++
Sbjct: 925 EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILE 984
Query: 181 QLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQH-LYEE 239
+L KE+ L +F T + + EEK++ LK K A +++ L E
Sbjct: 985 DQNCKLAKEKKLLEDRIAEFTTNLTEE-----EEKSKSLAKLKNKHEAMITDLEERLRRE 1039
Query: 240 MEQQIKSEKEQFLLKDTE--------RFQARSQELEQKLLCKEQEL--------EQLTQK 283
+Q+ + EK + L+ QA+ EL+ +L KE+EL E+ QK
Sbjct: 1040 EKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099
Query: 284 Q------KRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ 337
+ LE Q + L D +A K + ++L ELE EL+D + Q
Sbjct: 1100 NMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQ 1159
Query: 338 QEACKLHQEKEMEVYRVTESLQRE 361
+ L ++E EV + ++L+ E
Sbjct: 1160 E----LRSKREQEVNILKKTLEEE 1179
Score = 55.5 bits (132), Expect = 8e-08
Identities = 62/244 (25%), Positives = 124/244 (50%), Gaps = 22/244 (9%)
Query: 130 EQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDR---LGAQKVLEDESDVKQLWLQL 186
E A+ E + L+ ++L ++ D EA+ +R L A+K + + ++++L QL
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK-KMQQNIQELEEQL 952
Query: 187 KKEEPHLLS-NFEDFLTRIISQLQEAHEEKNELE---CALKRKIAAYDEEIQHLYEEMEQ 242
++EE E T ++L++ EE+ LE C L ++ ++ I + +
Sbjct: 953 EEEESARQKLQLEKVTTE--AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE 1010
Query: 243 QIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETK 302
+ EK + L K + +A +LE++L +E++ ++L + +++LEG T L E +
Sbjct: 1011 E--EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQ 1068
Query: 303 AENTKLKLTNQELARELERTSWELQDAQQQLE---SLQQEACKLHQEKEMEVYRVTESLQ 359
A+ +LK+ +LA++ E ELQ A ++E + + A K +E E ++ + E L+
Sbjct: 1069 AQIAELKM---QLAKKEE----ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLE 1121
Query: 360 REKA 363
E+A
Sbjct: 1122 SERA 1125
Score = 47.8 bits (112), Expect = 2e-05
Identities = 72/369 (19%), Positives = 154/369 (41%), Gaps = 51/369 (13%)
Query: 34 DSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFI----ARKDMQRLHKELPLSLEEL 89
+++EQK E+ + Q + ++ + D GK +++ +++ +E+ LEEL
Sbjct: 1487 EAMEQKAELERLNKQF--RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEEL 1544
Query: 90 EDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDED 148
ED A DA + Q F ++ S+E + V Q E + L
Sbjct: 1545 EDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL------ 1598
Query: 149 LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL------KKEEPHLLSNFEDFLT 202
EDE Q M + A+K LE D+K L + + E L + +
Sbjct: 1599 -----EDERKQRSMAV---AARKKLE--MDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK 1648
Query: 203 RIISQLQEAHEEKNELECALK---RKIAAYDEEIQHLYEEM------EQQIKSEKEQFL- 252
+ +L + + E+ K +K+ + + E+ L EE+ ++Q + E+++
Sbjct: 1649 DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD 1708
Query: 253 ------------LKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE 300
L++ R +AR +LE++L ++ E + + K+ Q ++ D +
Sbjct: 1709 EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNL 1768
Query: 301 TKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
++ K + Q+L R+ + +LQ+ + ++S + + + K ++ ++ +
Sbjct: 1769 ERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETK 1828
Query: 361 EKAGLLKQL 369
E+ KQ+
Sbjct: 1829 ERQAACKQV 1837
Score = 45.4 bits (106), Expect = 9e-05
Identities = 57/258 (22%), Positives = 107/258 (41%), Gaps = 23/258 (8%)
Query: 129 GEQVAQRHEEKVYLSRGDED--LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQL 186
GE+V +KV + + D G + + + ++ D + L+D ++ Q +
Sbjct: 1264 GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQ 1323
Query: 187 KKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI-- 244
K L ED QL+E E K+ LE ++IA ++ + ++ME +
Sbjct: 1324 KLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLE----KQIATLHAQVADMKKKMEDSVGC 1379
Query: 245 ---KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHET 301
E ++ L KD E SQ E+K+ ++ + T+ Q+ L+ L H +
Sbjct: 1380 LETAEEVKRKLQKDLE---GLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 302 KAENTKLKLTNQELAREL--------ERTSWELQDAQQQLESLQ-QEACKLHQEKEMEVY 352
K K +Q LA E ER E + +++ ++L A + E++ E+
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 353 RVTESLQREKAGLLKQLD 370
R+ + + E L+ D
Sbjct: 1497 RLNKQFRTEMEDLMSSKD 1514
Score = 43.5 bits (101), Expect = 3e-04
Identities = 76/358 (21%), Positives = 153/358 (42%), Gaps = 39/358 (10%)
Query: 33 LDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDV 92
+ LE++ +E+++ Q + L K + E + I +L KE L LED
Sbjct: 945 IQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL----LEDR 1000
Query: 93 FDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSR------GD 146
A+ LT +E + +++ D E++ + +++ L + GD
Sbjct: 1001 I----AEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 147 E-DLGDMGEDEEAQFRMLMDRLGAQKV--------LEDESDVKQLWLQLKKEEPHLLSNF 197
DL D + +AQ L +L ++ +E+E+ K + L+ +E +S
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 198 EDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDT- 256
++ L + +A ++K +L L+ ++ + + E + K E+E +LK T
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 257 ----ERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTN 312
+ +A+ QE+ QK +EL + ++ KR++ +K + EN + +L N
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANL-----EKAKQTLENERGELAN 1231
Query: 313 QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLD 370
+ + L + + + ++++E+ QE Q K E RV L + L +LD
Sbjct: 1232 E--VKVLLQGKGDSEHKRKKVEAQLQEL----QVKFNEGERVRTELADKVTKLQVELD 1283
Score = 40.0 bits (92), Expect = 0.004
Identities = 44/244 (18%), Positives = 110/244 (45%), Gaps = 15/244 (6%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQ 185
E A Q Q +E G + +E+ + + +L +++ E++ + + + +
Sbjct: 1693 ERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQL-EEELEEEQGNTELINDR 1751
Query: 186 LKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIK 245
LKK +N + L+ +H +KNE ++++ ++E++ +EME +K
Sbjct: 1752 LKK------ANLQIDQINTDLNLERSHAQKNE---NARQQLERQNKELKVKLQEMEGTVK 1802
Query: 246 SEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAEN 305
S+ + + + ++L+ + ++ +Q+ + +K+L+ L D AE
Sbjct: 1803 SKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKD--VLLQVDDERRNAEQ 1860
Query: 306 TKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGL 365
K + + + L++ +L++A+++ + KL +E E + +++ RE + L
Sbjct: 1861 YKDQA--DKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELE-DATETADAMNREVSSL 1917
Query: 366 LKQL 369
+L
Sbjct: 1918 KNKL 1921
Score = 39.7 bits (91), Expect = 0.005
Identities = 56/257 (21%), Positives = 109/257 (42%), Gaps = 19/257 (7%)
Query: 120 QNNPSQEDAGEQVAQRHEEKVYLSRGDED-LGDMGEDEEAQFRMLMDRLGAQKVLEDESD 178
+ ++ + +Q+A H + + + ED +G + EE + ++ D G + E++
Sbjct: 1347 EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVA 1406
Query: 179 VKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEA------HEEKNELECALKRKIAAYDEE 232
+L+K + L +D L + Q Q A ++ ++L K A Y EE
Sbjct: 1407 AYD---KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 233 IQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCT 292
E E + K K L + E + ELE+ E+E L + +
Sbjct: 1464 RDRA--EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 293 ALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVY 352
L K + + ++K +EL EL+ T +DA+ +LE + +A K E++++
Sbjct: 1522 ELEKSKRALEQQVEEMKTQLEELEDELQAT----EDAKLRLE-VNLQAMKAQFERDLQ-- 1574
Query: 353 RVTESLQREKAGLLKQL 369
E + +K L++Q+
Sbjct: 1575 GRDEQSEEKKKQLVRQV 1591
Score = 35.8 bits (81), Expect = 0.069
Identities = 32/120 (26%), Positives = 57/120 (47%), Gaps = 21/120 (17%)
Query: 267 EQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQ-----ELARELER 321
E++++ KE+EL ++ +KQ E + T + + + AE KL+L Q EL E E
Sbjct: 844 EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE--KLQLQEQLQAETELCAEAEE 901
Query: 322 TSWELQDAQQQLESL----------QQEACK-LHQEK---EMEVYRVTESLQREKAGLLK 367
L +Q+LE + ++E C+ L EK + + + E L+ E++ K
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 58.2 bits (139), Expect = 1e-08
Identities = 79/355 (22%), Positives = 145/355 (40%), Gaps = 47/355 (13%)
Query: 31 HPLDSLEQKETQEQTSGQ--LVMLRKAQEFF-----QTCDAEGKGFIARKDMQRLHKELP 83
H LD +Q+ ++Q Q LR+AQ Q D + K +Q+ + +
Sbjct: 481 HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540
Query: 84 LSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLS 143
L +E ED++ + A E T + +N+ QE + + +
Sbjct: 541 LLEKEREDLYAKIQAG--------EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHK 592
Query: 144 RGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTR 203
+ E+L D ++++A R DR VL E+ V +L QL + +
Sbjct: 593 QAQENLHDQVQEQKAHLRAAQDR-----VLSLETSVNELNSQLNESKEK----------- 636
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
+SQL + K EL + + A ++Q+ + + Q +K+Q L K T +
Sbjct: 637 -VSQLDIQIKAKTELLLSAEAAKTAQRADLQN-HLDTAQNALQDKQQELNKITTQLD--- 691
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTS 323
++ KL K++ QL K + + +L E + + KL+ + E+ E+
Sbjct: 692 -QVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQAL 750
Query: 324 WELQDAQQQLESLQQEACKLHQEKEME----------VYRVTESLQREKAGLLKQ 368
+LQ +Q L+ A +L ++ EME + + +E+L+ K L KQ
Sbjct: 751 QDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQ 805
Score = 52.4 bits (124), Expect = 7e-07
Identities = 78/355 (21%), Positives = 147/355 (41%), Gaps = 32/355 (9%)
Query: 38 QKETQEQTSGQLVMLRKAQEFFQTCDA----------EGKGFIARKDMQ-RLHKELPLSL 86
Q+ +Q Q LR AQ+ + + E K +++ D+Q + EL LS
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 87 EELE-----DVFDALDADGNGYLTPQE----FTTGFSHFFFSQNNPSQEDAGEQVAQRHE 137
E + D+ + LD N Q+ TT + + + + +
Sbjct: 655 EAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY 714
Query: 138 EKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNF 197
++ YLS + G+ ++ + L + ++ L+D +QL L+ L
Sbjct: 715 KEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQL 774
Query: 198 EDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHL---YEEMEQQIKSEKEQFLLK 254
E I+S + ++K+E ++K+K+ +EE Q L +E + Q+ K + E+
Sbjct: 775 E-MEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEEL--- 830
Query: 255 DTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQE 314
R Q EL++ + KE + +L+ + +L +L + K E + EN K K +
Sbjct: 831 -NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILD 889
Query: 315 LARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
L + + +LQ Q + +Q+ K EKE E + L+ E + +QL
Sbjct: 890 LEKTCKELKHQLQ-VQMENTLKEQKELKKSLEKEKE---ASHQLKLELNSMQEQL 940
Score = 50.8 bits (120), Expect = 2e-06
Identities = 53/195 (27%), Positives = 88/195 (45%), Gaps = 31/195 (15%)
Query: 194 LSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQ--QIKSEKEQF 251
LS E L RI +L E K E LK +++ + + QHL E +Q Q + EKEQ
Sbjct: 353 LSASETSLHRIHVELSE----KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408
Query: 252 LLK-------------DTER--------FQARSQELEQKLLCKEQELEQLTQKQKRLEGQ 290
L+ +TER + + Q +KL+ KEQ++ L K RLE Q
Sbjct: 409 GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQ 468
Query: 291 CTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEME 350
+ E + + K K +QE + T+ +L++AQ LE + ++ +K+ +
Sbjct: 469 LKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQI----GDKDQK 524
Query: 351 VYRVTESLQREKAGL 365
+ + LQ+ K +
Sbjct: 525 IQNLEALLQKSKENI 539
Score = 48.1 bits (113), Expect = 1e-05
Identities = 74/329 (22%), Positives = 144/329 (43%), Gaps = 33/329 (10%)
Query: 30 LHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEEL 89
L L S + TQ+ + +L+K Q++ + + + +++K++Q + L ++L
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 90 EDVFDA---------LDADGNGYLTPQ------EFTTGFSHF--FFSQNNPSQEDAGEQV 132
+ A ++ G T + E T + H F Q +E+ +
Sbjct: 350 QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHG 409
Query: 133 AQRHEEKVYL-SRGDEDLGDMGEDEEAQFRMLMDR-LGAQKVLEDESDVKQLWLQLKKEE 190
Q E L S+ E +G EA R+ R L ++K+++ E V L L+L + E
Sbjct: 410 LQLQSEINQLHSKLLETERQLG---EAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE 466
Query: 191 PHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQ 250
L + T + QL + ++ E + AL++ A E Q+ E++ +QI +K+Q
Sbjct: 467 EQLKEKVTN-STELQHQLDKTKQQHQEQQ-ALQQSTTAKLREAQNDLEQVLRQI-GDKDQ 523
Query: 251 FLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKL 310
+ + +A Q+ ++ + E+E E L K + EG+ L ++ + +N L+
Sbjct: 524 KI----QNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTLQE 575
Query: 311 TNQELARELERTSWELQDAQQQLESLQQE 339
+L +L+ S + AQ+ L QE
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQE 604
Score = 47.8 bits (112), Expect = 2e-05
Identities = 80/368 (21%), Positives = 156/368 (42%), Gaps = 34/368 (9%)
Query: 34 DSLEQKETQEQT-SGQLVMLRKAQEF----FQTCDAEGKGFIARKDM--QRLHKELPLSL 86
++L+Q E +EQ G + L+++ E + E K + +K +L ++L +
Sbjct: 945 NTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAA 1004
Query: 87 EELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGD 146
+EL + + N Y QE F+ + S+ A Q + EEK LS
Sbjct: 1005 QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE--SELLATRQDLKSVEEK--LSLAQ 1060
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIIS 206
EDL Q +++ + A+ LE +S K+ LQ + + + + + +
Sbjct: 1061 EDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELV 1120
Query: 207 QLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE--QFLLKDTERFQARS- 263
+ E E++C +++I +EE++ E ++I + K+ Q L++ Q ++
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 264 -------QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHE-----TKAENTKLKLT 311
QE + + K+Q ++ + +K + LH + E K E + KLT
Sbjct: 1181 SLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLT 1240
Query: 312 NQ--ELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
Q L L E Q +Q+++ L+++ L E + + ++ Q E+ LL+
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV-LEATVQNNQDERRALLE-- 1297
Query: 370 DFLRCVGG 377
RC+ G
Sbjct: 1298 ---RCLKG 1302
Score = 45.8 bits (107), Expect = 7e-05
Identities = 48/224 (21%), Positives = 101/224 (45%), Gaps = 13/224 (5%)
Query: 154 EDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHE 213
+++EA ++ ++ Q+ L + + Q +KEE L N + + ++
Sbjct: 921 KEKEASHQLKLELNSMQEQLIQAQNTLK---QNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 214 EKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQF--LLKDTERFQARSQELEQKLL 271
+ EL+ A+ +K + ++Q + Q++ +EKE+ L + E+ Q ++L+
Sbjct: 978 LQGELKIAVLQK-TELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY 1036
Query: 272 CKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQ-ELARELERTSWELQDAQ 330
+E EL Q K +E + + D + + + NQ +L +EL+ L+
Sbjct: 1037 GRESELLATRQDLKSVEEKLSLAQEDLISNRNQ-----IGNQNKLIQELKTAKATLEQDS 1091
Query: 331 QQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRC 374
+ E QE CK Q+ + E + L EK+ L +++ ++C
Sbjct: 1092 AKKEQQLQERCKALQDIQKEKSLKEKELVNEKS-KLAEIEEIKC 1134
Score = 44.3 bits (103), Expect = 2e-04
Identities = 53/206 (25%), Positives = 98/206 (47%), Gaps = 13/206 (6%)
Query: 145 GDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRI 204
G ED+ + + E Q + LMD + LE E + ++L + KK + S+ E ++++
Sbjct: 219 GIEDVAVL-KKELVQVQTLMDNM----TLERERESEKLKDECKKLQSQYASS-EATISQL 272
Query: 205 ISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQ 264
S+L + +E L++ ++ +E Q E +K E++ L++ ++ S+
Sbjct: 273 RSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSK 332
Query: 265 E-LEQKLLCKEQELEQLTQKQKRLEGQCTALH--HDKHETKAENT-KLKLTNQELARELE 320
+ ++ L K+ + +QL Q RL T+LH H + K E T KLK E+ + +
Sbjct: 333 KNIQATLHQKDLDCQQL---QSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQ 389
Query: 321 RTSWELQDAQQQLESLQQEACKLHQE 346
E + QQQ E +Q +L E
Sbjct: 390 HLKAEFKQLQQQREEKEQHGLQLQSE 415
Score = 39.7 bits (91), Expect = 0.005
Identities = 46/238 (19%), Positives = 106/238 (44%), Gaps = 37/238 (15%)
Query: 168 GAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIA 227
G +L+ E K+L QL+ + + L ++ + + + +H+ K EL ++ I
Sbjct: 883 GKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQ 942
Query: 228 AY---------DEEIQHLYEEMEQQIKSEKEQF----------LLKDTE---RFQARSQE 265
A ++++Q E++Q + +K+Q +L+ TE + Q + +
Sbjct: 943 AQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQ 1002
Query: 266 LEQKLLCKEQEL-----------EQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQE 314
Q+L +++++ E Q Q G+ + L + + K+ KL L ++
Sbjct: 1003 AAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 315 L---ARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
L ++ + +Q+ + +L+Q++ K Q+ + E + + +Q+EK+ K+L
Sbjct: 1063 LISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ-ERCKALQDIQKEKSLKEKEL 1119
Score = 39.3 bits (90), Expect = 0.006
Identities = 46/215 (21%), Positives = 97/215 (45%), Gaps = 38/215 (17%)
Query: 170 QKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAY 229
QK+ E+ S+V+ + LK E QLQ+ EEK + L+ +I
Sbjct: 375 QKLKEELSEVETKYQHLKAE---------------FKQLQQQREEKEQHGLQLQSEINQL 419
Query: 230 DEEIQHLYEEM---------EQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQL 280
++ ++ ++Q+ SEK + Q + LE++L ++++
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQL---KEKVTNS 476
Query: 281 TQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQ--- 337
T+ Q +L+ T H + + ++T KL +E +LE+ ++ D Q++++L+
Sbjct: 477 TELQHQLDK--TKQQHQEQQALQQSTTAKL--REAQNDLEQVLRQIGDKDQKIQNLEALL 532
Query: 338 ---QEACKLHQEKEMEVYRVTESLQREKAGLLKQL 369
+E L +++ ++Y ++ + E A +L QL
Sbjct: 533 QKSKENISLLEKEREDLYAKIQAGEGETA-VLNQL 566
Score = 37.0 bits (84), Expect = 0.031
Identities = 37/142 (26%), Positives = 64/142 (45%), Gaps = 15/142 (10%)
Query: 185 QLKKEEPHLLSNFEDFLTRIISQLQEAH---EEKNELECALKRKIAAYDEEIQHLYEEME 241
Q+KKEE L F + ++ S+++E ++ E E L +I A +E + + +E +
Sbjct: 1199 QVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQ 1258
Query: 242 QQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHET 301
+ E L K T+ + LE + + E L ++ + EG+ +K +T
Sbjct: 1259 SSQRRVSE--LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEI-----EKLQT 1311
Query: 302 KAENTKLKLTN-----QELARE 318
K + KL N QEL RE
Sbjct: 1312 KVLELQRKLDNTTAAVQELGRE 1333
Score = 30.4 bits (67), Expect = 2.9
Identities = 24/86 (27%), Positives = 38/86 (44%), Gaps = 3/86 (3%)
Query: 267 EQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARE---LERTS 323
E L K ++ L Q+ + L+ E K E K + Q+ A+ + +S
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 324 WELQDAQQQLESLQQEACKLHQEKEM 349
ELQ +QQLE Q E + Q K++
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDL 160
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 58.2 bits (139), Expect = 1e-08
Identities = 80/355 (22%), Positives = 154/355 (43%), Gaps = 35/355 (9%)
Query: 54 KAQEFFQTCDAEGKGFIARKDMQRLHKELPLS---LEELEDVFDALDADGNGYLTPQEFT 110
+A E +T E K ++++ L ++ LS ++ELE AL+ + + E
Sbjct: 1539 EALEALETLKRENKNL--QEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA 1596
Query: 111 TGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQ 170
G ++ Q + + A+ + L+ DE+ ++ + + L L A+
Sbjct: 1597 EGALELEETKTLRIQLELSQVKAEVDRK---LAEKDEECANLRRNHQRAVESLQASLDAE 1653
Query: 171 KVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYD 230
+E+ L+LKK+ L++ E L Q EA ++ LK + A D
Sbjct: 1654 TRARNEA------LRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRD 1707
Query: 231 EEIQHLYEEMEQQIKS--EKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLE 288
EE Q L E+ +Q ++ + L + E +A ++ E+ EQEL + T++ L
Sbjct: 1708 EE-QRLAAELHEQAQALERRASLLAAELEELRAALEQGERSRRLAEQELLEATERLNLLH 1766
Query: 289 GQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLE------SLQQEACK 342
Q T L + K + +A+ +L+ E+E + E ++A+++ + ++ E K
Sbjct: 1767 SQNTGLLNQKKKLEADLA-------QLSGEVEEAAQERREAEEKAKKAITDAAMMAEELK 1819
Query: 343 LHQEKEMEVYRVTESLQ---REKAGLLKQLDFLRCVGGHWPV--LRAPPRSLGSE 392
Q+ + R+ ++L+ RE L++ + GG V L A R L +E
Sbjct: 1820 KEQDTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAE 1874
Score = 55.1 bits (131), Expect = 1e-07
Identities = 69/271 (25%), Positives = 118/271 (43%), Gaps = 43/271 (15%)
Query: 130 EQVAQRHEEKVYLSRGDED-LGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKK 188
E VA+ +EK L + LGD+ +E+ + +L ++ +ED + +L+
Sbjct: 1036 ESVARLTKEKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRM 1095
Query: 189 EEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEK 248
+ E L + +A ++K +LE LK+K D E+ L ++ E
Sbjct: 1096 DTERAKRKLEGDLKLTQESVADAAQDKQQLEEKLKKK----DSELSQL------SLRVED 1145
Query: 249 EQFL----LKDTERFQARSQELEQKLLCKE--------------QELEQLTQKQKRLEGQ 290
EQ L K + QAR++ELE++L + +ELE+L+++ + G
Sbjct: 1146 EQLLGAQMQKKIKELQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGA 1205
Query: 291 CTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQ--------QQLESLQQEACK 342
+ +AE +L+ +E A E T L+ Q +Q++SLQ+ K
Sbjct: 1206 SAGQREGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQK 1265
Query: 343 LHQEK---EMEVYRV---TESLQREKAGLLK 367
L +EK MEV + E+L R KA K
Sbjct: 1266 LEKEKSELRMEVDDLAANVETLTRAKASAEK 1296
Score = 51.6 bits (122), Expect = 1e-06
Identities = 68/322 (21%), Positives = 135/322 (41%), Gaps = 19/322 (5%)
Query: 64 AEGKGFIARK--DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQN 121
AEG + + +QR+ ++L EL D L A+ + + Q
Sbjct: 1246 AEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTRAKASAEKLCRTYEDQL 1305
Query: 122 NPSQ---EDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESD 178
+ ++ E+ Q+A ++ L +L + E++E L+ +L K L +S
Sbjct: 1306 SEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKEC----LISQLSRGKALAAQS- 1360
Query: 179 VKQLWLQLKKEEP--HLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHL 236
+++L QL++E L++ L L+E HEE+ E + L+R ++ + E+
Sbjct: 1361 LEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQW 1420
Query: 237 YEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHH 296
+ E E+ L + ++ R QE E+ + + L + + RL+ + +
Sbjct: 1421 RSKYEADAIQRTEE-LEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTL 1479
Query: 297 DKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQE------KEME 350
+ + L + L R LE + ++ Q++LE+ Q+E+ L E E
Sbjct: 1480 ELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEE 1539
Query: 351 VYRVTESLQREKAGLLKQLDFL 372
E+L+RE L +++ L
Sbjct: 1540 ALEALETLKRENKNLQEEISDL 1561
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/146 (22%), Positives = 70/146 (47%), Gaps = 24/146 (16%)
Query: 207 QLQEAH----EEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQAR 262
+L+E H +EKN+L L+ E+ E+ L+K + + +
Sbjct: 921 ELEETHVSITQEKNDLALQLQA-------------EQDNLADAEERCHLLIKSKVQLEGK 967
Query: 263 SQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERT 322
+EL ++L +E+ L ++++LE +CT E K + LKLT + +E + T
Sbjct: 968 VKELSERLEDEEEVNADLAARRRKLEDECT-------ELKKDIDDLKLTLAKAEKEKQAT 1020
Query: 323 SWELQDAQQQLESLQQEACKLHQEKE 348
++++ +++ +L + +L +EK+
Sbjct: 1021 ENKVKNLTEEMAALDESVARLTKEKK 1046
Score = 39.3 bits (90), Expect = 0.006
Identities = 67/311 (21%), Positives = 117/311 (37%), Gaps = 33/311 (10%)
Query: 75 MQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQ 134
MQ+ KEL EELE + L+A+ ++ + + +E G Q
Sbjct: 1153 MQKKIKELQARAEELE---EELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQ 1209
Query: 135 R---HEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRL--GAQKVLEDESDVKQLWLQLKKE 189
R + + L R +L + EA L + GA ++ E ++++ +L+KE
Sbjct: 1210 REGCRKREAELGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKE 1269
Query: 190 EPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKE 249
+ L +D + E + + ++ Y++++ E +IK E+
Sbjct: 1270 KSELRMEVDDLAANV--------ETLTRAKASAEKLCRTYEDQLS------EAKIKVEEL 1315
Query: 250 QFLLKDTE----RFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAEN 305
Q L D R Q S EL + L KE + QL++ + L E
Sbjct: 1316 QRQLADASTQRGRLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAK 1375
Query: 306 TKLKLTNQ------ELARELERTSWELQ-DAQQQLESLQQEACKLHQEKEMEVYRVTESL 358
+ L Q +L RE E Q + Q+ L E + + E + + TE L
Sbjct: 1376 SALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEEL 1435
Query: 359 QREKAGLLKQL 369
+ K L +L
Sbjct: 1436 EEAKKKLALRL 1446
Score = 39.3 bits (90), Expect = 0.006
Identities = 56/259 (21%), Positives = 105/259 (40%), Gaps = 50/259 (19%)
Query: 134 QRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHL 193
++HEE+ + L E AQ+R + Q+ E E K+L L+L++ E +
Sbjct: 1394 EQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV 1453
Query: 194 ------LSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSE 247
S+ E R+ + E+ + ELE A AA D++ +HL +E++ + E
Sbjct: 1454 EAANAKCSSLEKAKLRLQT---ESEDVTLELERATSAA-AALDKKQRHLERALEERRRQE 1509
Query: 248 KEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTK 307
+E ++ELE ++ + L + L H E
Sbjct: 1510 EEM-----------------------QRELEAAQRESRGLGTELFRLRHGHEEALEALET 1546
Query: 308 LKLTNQEL-----------------ARELERTSWELQDAQQQLESLQQEACKLHQEKEME 350
LK N+ L +ELE+T L+ + ++++ +EA + +E +
Sbjct: 1547 LKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETK 1606
Query: 351 VYRVTESLQREKAGLLKQL 369
R+ L + KA + ++L
Sbjct: 1607 TLRIQLELSQVKAEVDRKL 1625
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 57.4 bits (137), Expect = 2e-08
Identities = 52/190 (27%), Positives = 96/190 (50%), Gaps = 29/190 (15%)
Query: 194 LSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEE---IQHLYEEMEQQIKSEKEQ 250
L+N ++ L+ + SQ++E E++ ++ LK K A EE +Q +E ++ ++EQ
Sbjct: 786 LTNLQENLSEV-SQVKETLEKELQI---LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ 841
Query: 251 F--LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLE--------------GQCTAL 294
F L D E+ + ++E K K++ EQL + +++LE Q T +
Sbjct: 842 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 901
Query: 295 HHDKH--ETKAENTKLKLTN-QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
+ + E E +LKLT E A L+++ ++D + E QQEA K H+E++ E+
Sbjct: 902 NDELRLKERDVEELQLKLTKANENASFLQKS---IEDMTVKAEQSQQEAAKKHEEEKKEL 958
Query: 352 YRVTESLQRE 361
R L+++
Sbjct: 959 ERKLSDLEKK 968
Score = 49.7 bits (117), Expect = 5e-06
Identities = 78/310 (25%), Positives = 121/310 (39%), Gaps = 75/310 (24%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
++D E+ + +EK L ++ M D +Q + D L + E DV++L L
Sbjct: 865 EKDEREEQLIKAKEK--LENDIAEIMKMSGDNSSQLTKMNDELRLK-----ERDVEELQL 917
Query: 185 QLKKEEPH---LLSNFEDFLTRIISQLQEA----HEEKNELE---CALKRKIAAYDEEIQ 234
+L K + L + ED + QEA EEK ELE L++K+ + Q
Sbjct: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
Query: 235 HL---YEEMEQQIKSEKEQFL------LKDTERFQARSQELEQKLLCKEQELEQLTQKQK 285
L YE + K++ E+ L L DTE ++E LL QELE+L ++
Sbjct: 978 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL---QELEELRKQAD 1034
Query: 286 RLEGQCTA---------LHHDKHETKAENTKLKLTN------------------------ 312
+ + TA + +K ET A K TN
Sbjct: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
Query: 313 -----------QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVT--ESLQ 359
+E +E+E QQL +LQ+E KL +E VT + L+
Sbjct: 1095 KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLE 1154
Query: 360 REKAGLLKQL 369
E++ L QL
Sbjct: 1155 EERSVLNNQL 1164
Score = 47.4 bits (111), Expect = 2e-05
Identities = 55/221 (24%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQ--KVL-EDESDVKQLWLQLKKEEPHLLSNFEDFLTR 203
E+L + + E A M+ L A+ KV+ E E+ ++ + +L K E L ED L +
Sbjct: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 688
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
LQEA + ELE + A E + + Q+K+ +E+ L D R +
Sbjct: 689 ----LQEAEIKVKELEV-----LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 739
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTN----------- 312
+ E K L ++ E + K +E + + + +LKLTN
Sbjct: 740 GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
Query: 313 -QELARELERTSWELQDAQQQL----ESLQQEACKLHQEKE 348
+ L +EL+ + +A ++ S+Q+ KLHQ++E
Sbjct: 800 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 840
Score = 42.4 bits (98), Expect = 7e-04
Identities = 61/257 (23%), Positives = 116/257 (45%), Gaps = 39/257 (15%)
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSN 196
E KV S+G LG E A+F L ++ + L+ + +++ L Q E
Sbjct: 594 ELKVSFSKG---LGT----ETAEFAELKTQIEKMR-LDYQHEIENLQNQQDSERAAHAKE 645
Query: 197 FEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDT 256
E +++ ++E ++N LE A++ K+ ++ QHL E + K ++ + +K+
Sbjct: 646 MEALRAKLMKVIKE---KENSLE-AIRSKLDKAED--QHLVEMEDTLNKLQEAEIKVKEL 699
Query: 257 ERFQARSQE--------------LEQKLL-------CKEQELEQLTQKQKRLEGQCTALH 295
E QA+ E E+KLL + ++ + +++LE +
Sbjct: 700 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 759
Query: 296 HDKHETKAENTKLKLTNQEL-ARELERTSWE--LQDAQQQLESLQQEACKLHQEKEMEVY 352
H + E AE++K +EL REL+ T+ + L + Q E+L++E ++ +EK E
Sbjct: 760 HLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE-LQILKEKFAEAS 818
Query: 353 RVTESLQREKAGLLKQL 369
S+QR + +L
Sbjct: 819 EEAVSVQRSMQETVNKL 835
Score = 39.7 bits (91), Expect = 0.005
Identities = 50/242 (20%), Positives = 105/242 (43%), Gaps = 44/242 (18%)
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKR--KIAAYDE 231
E+ S+V Q+ L+KE L F + +S + E N+L ++ +++ E
Sbjct: 791 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 850
Query: 232 EIQHLYEEMEQQI--KSEKEQFLLKDTERFQ--------------ARSQELEQKLLCKEQ 275
+++ +ME + K E+E+ L+K E+ + ++ ++ +L KE+
Sbjct: 851 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 910
Query: 276 ELEQLTQK-----------QKRLEGQCTALHHD------KHETKAENTKLKLTNQELARE 318
++E+L K QK +E KHE + + + KL+ +L ++
Sbjct: 911 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS--DLEKK 968
Query: 319 LERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRV-------TESLQREKAGLLKQLDF 371
+E + + Q+ + + E E H+E + + + + E +GLL++L+
Sbjct: 969 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1028
Query: 372 LR 373
LR
Sbjct: 1029 LR 1030
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 57.4 bits (137), Expect = 2e-08
Identities = 52/190 (27%), Positives = 96/190 (50%), Gaps = 29/190 (15%)
Query: 194 LSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEE---IQHLYEEMEQQIKSEKEQ 250
L+N ++ L+ + SQ++E E++ ++ LK K A EE +Q +E ++ ++EQ
Sbjct: 821 LTNLQENLSEV-SQVKETLEKELQI---LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQ 876
Query: 251 F--LLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLE--------------GQCTAL 294
F L D E+ + ++E K K++ EQL + +++LE Q T +
Sbjct: 877 FNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKM 936
Query: 295 HHDKH--ETKAENTKLKLTN-QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEV 351
+ + E E +LKLT E A L+++ ++D + E QQEA K H+E++ E+
Sbjct: 937 NDELRLKERDVEELQLKLTKANENASFLQKS---IEDMTVKAEQSQQEAAKKHEEEKKEL 993
Query: 352 YRVTESLQRE 361
R L+++
Sbjct: 994 ERKLSDLEKK 1003
Score = 49.7 bits (117), Expect = 5e-06
Identities = 78/310 (25%), Positives = 121/310 (39%), Gaps = 75/310 (24%)
Query: 125 QEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL 184
++D E+ + +EK L ++ M D +Q + D L + E DV++L L
Sbjct: 900 EKDEREEQLIKAKEK--LENDIAEIMKMSGDNSSQLTKMNDELRLK-----ERDVEELQL 952
Query: 185 QLKKEEPH---LLSNFEDFLTRIISQLQEA----HEEKNELE---CALKRKIAAYDEEIQ 234
+L K + L + ED + QEA EEK ELE L++K+ + Q
Sbjct: 953 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 1012
Query: 235 HL---YEEMEQQIKSEKEQFL------LKDTERFQARSQELEQKLLCKEQELEQLTQKQK 285
L YE + K++ E+ L L DTE ++E LL QELE+L ++
Sbjct: 1013 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL---QELEELRKQAD 1069
Query: 286 RLEGQCTA---------LHHDKHETKAENTKLKLTN------------------------ 312
+ + TA + +K ET A K TN
Sbjct: 1070 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS 1129
Query: 313 -----------QELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVT--ESLQ 359
+E +E+E QQL +LQ+E KL +E VT + L+
Sbjct: 1130 KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLE 1189
Query: 360 REKAGLLKQL 369
E++ L QL
Sbjct: 1190 EERSVLNNQL 1199
Score = 47.4 bits (111), Expect = 2e-05
Identities = 55/221 (24%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 147 EDLGDMGEDEEAQFRMLMDRLGAQ--KVL-EDESDVKQLWLQLKKEEPHLLSNFEDFLTR 203
E+L + + E A M+ L A+ KV+ E E+ ++ + +L K E L ED L +
Sbjct: 664 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK 723
Query: 204 IISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARS 263
LQEA + ELE + A E + + Q+K+ +E+ L D R +
Sbjct: 724 ----LQEAEIKVKELEV-----LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSE 774
Query: 264 QELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTN----------- 312
+ E K L ++ E + K +E + + + +LKLTN
Sbjct: 775 GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 834
Query: 313 -QELARELERTSWELQDAQQQL----ESLQQEACKLHQEKE 348
+ L +EL+ + +A ++ S+Q+ KLHQ++E
Sbjct: 835 KETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 875
Score = 42.4 bits (98), Expect = 7e-04
Identities = 61/257 (23%), Positives = 116/257 (45%), Gaps = 39/257 (15%)
Query: 137 EEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSN 196
E KV S+G LG E A+F L ++ + L+ + +++ L Q E
Sbjct: 629 ELKVSFSKG---LGT----ETAEFAELKTQIEKMR-LDYQHEIENLQNQQDSERAAHAKE 680
Query: 197 FEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDT 256
E +++ ++E ++N LE A++ K+ ++ QHL E + K ++ + +K+
Sbjct: 681 MEALRAKLMKVIKE---KENSLE-AIRSKLDKAED--QHLVEMEDTLNKLQEAEIKVKEL 734
Query: 257 ERFQARSQE--------------LEQKLL-------CKEQELEQLTQKQKRLEGQCTALH 295
E QA+ E E+KLL + ++ + +++LE +
Sbjct: 735 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIK 794
Query: 296 HDKHETKAENTKLKLTNQEL-ARELERTSWE--LQDAQQQLESLQQEACKLHQEKEMEVY 352
H + E AE++K +EL REL+ T+ + L + Q E+L++E ++ +EK E
Sbjct: 795 HLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE-LQILKEKFAEAS 853
Query: 353 RVTESLQREKAGLLKQL 369
S+QR + +L
Sbjct: 854 EEAVSVQRSMQETVNKL 870
Score = 39.7 bits (91), Expect = 0.005
Identities = 50/242 (20%), Positives = 105/242 (43%), Gaps = 44/242 (18%)
Query: 174 EDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKR--KIAAYDE 231
E+ S+V Q+ L+KE L F + +S + E N+L ++ +++ E
Sbjct: 826 ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLE 885
Query: 232 EIQHLYEEMEQQI--KSEKEQFLLKDTERFQ--------------ARSQELEQKLLCKEQ 275
+++ +ME + K E+E+ L+K E+ + ++ ++ +L KE+
Sbjct: 886 KLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKER 945
Query: 276 ELEQLTQK-----------QKRLEGQCTALHHD------KHETKAENTKLKLTNQELARE 318
++E+L K QK +E KHE + + + KL+ +L ++
Sbjct: 946 DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS--DLEKK 1003
Query: 319 LERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRV-------TESLQREKAGLLKQLDF 371
+E + + Q+ + + E E H+E + + + + E +GLL++L+
Sbjct: 1004 METSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEE 1063
Query: 372 LR 373
LR
Sbjct: 1064 LR 1065
Score = 30.8 bits (68), Expect = 2.2
Identities = 40/179 (22%), Positives = 74/179 (41%), Gaps = 18/179 (10%)
Query: 186 LKKEEPHLLSNF-EDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQI 244
LK+++ H+ E L R +H + E E AL R +D+ + L +M+Q
Sbjct: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD--GHDQHVLELEAKMDQL- 413
Query: 245 KSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAE 304
+A +E + L E+E ++ Q R+E + + +TK E
Sbjct: 414 -----------RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLE 462
Query: 305 NTKLKLTNQELARE---LERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQR 360
+ ++K Q L E ++ EL+D + S + +L ++ + V V E +R
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRR 521
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 57.4 bits (137), Expect = 2e-08
Identities = 69/243 (28%), Positives = 119/243 (48%), Gaps = 40/243 (16%)
Query: 121 NNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEA-QFRMLMDRLGAQKVLEDESDV 179
NN + E ++ + +EK+ LSR L + + +A Q+ + L A K LE +
Sbjct: 437 NNLATEAYERRIKRLEQEKLELSR---KLQESTQTVQALQYSTVDGPLTASKDLE----I 489
Query: 180 KQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEE 239
K L KEE L + + QL+EA+ + EL+ A R+I AY+++I+ L +E
Sbjct: 490 KNL-----KEEIEKLRKQVTESSHLEQQLEEANAVRQELDDAF-RQIKAYEKQIKTLQQE 543
Query: 240 MEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKH 299
E K L++ +ER + +S+EL+ ++ +++ + +RL T LH K
Sbjct: 544 REDLNKE-----LVQASERLKNQSKELKDAHCQRKLAMQEFMEINERL----TELHTQK- 593
Query: 300 ETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQ-EKEMEVYRVTESL 358
Q+LAR + E+ Q++ESL+QE + + +KE+EV+ TE+L
Sbjct: 594 -------------QKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVH--TEAL 638
Query: 359 QRE 361
E
Sbjct: 639 AAE 641
Score = 38.1 bits (87), Expect = 0.014
Identities = 57/276 (20%), Positives = 113/276 (40%), Gaps = 42/276 (15%)
Query: 126 EDAGEQVAQRHEEKVYLSRGDEDLG----DMGEDEEAQFRMLMD-----RLGAQKVLEDE 176
+DA Q+ ++ L + EDL E + Q + L D +L Q+ +E
Sbjct: 524 DDAFRQIKAYEKQIKTLQQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFMEIN 583
Query: 177 SDVKQLWLQLKKEEPHLLSNFEDF------LTRIISQLQEAHEEKNELE------CALKR 224
+ +L Q +K H+ E+ + + +L+ K ELE A
Sbjct: 584 ERLTELHTQKQKLARHVRDKEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALAAEAS 643
Query: 225 KIAAYDEEIQHLYEEMEQQIKSEKEQFL--------LKDTERFQARSQELEQKLLCKEQE 276
K E+ +H +++E +++ K++ + ++ + +LE+K + E+E
Sbjct: 644 KDRKLREQSEHYSKQLENELEGLKQKQISYSPGVCSIEHQQEITKLKTDLEKKSIFYEEE 703
Query: 277 LEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESL 336
L ++++ + L + H+++ + L L +LE+T E Q +++ ES
Sbjct: 704 L---SKREGIHANEIKNLKKELHDSEGQQLALNKEIMILKDKLEKTRRESQSEREEFES- 759
Query: 337 QQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFL 372
+ Q+ E E +TE E L +LD L
Sbjct: 760 -----EFKQQYEREKVLLTE----ENKKLTSELDKL 786
Score = 35.8 bits (81), Expect = 0.069
Identities = 67/315 (21%), Positives = 134/315 (42%), Gaps = 56/315 (17%)
Query: 72 RKDMQRLHKELPLSLEELEDVFDAL-DADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGE 130
+++ + L+KEL + E L++ L DA L QEF + E
Sbjct: 541 QQEREDLNKELVQASERLKNQSKELKDAHCQRKLAMQEFM----------------EINE 584
Query: 131 QVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWL------ 184
++ + H +K L+R D ++EE M Q++ E K+L +
Sbjct: 585 RLTELHTQKQKLARHVRD-----KEEEVDLVMQKVESLRQELRRTERAKKELEVHTEALA 639
Query: 185 -------QLKKEEPHLLSNFEDFLTRIISQLQ----------EAHEEKNELECALKRKIA 227
+L+++ H E+ L + Q Q E +E +L+ L++K
Sbjct: 640 AEASKDRKLREQSEHYSKQLENELEGL-KQKQISYSPGVCSIEHQQEITKLKTDLEKKSI 698
Query: 228 AYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRL 287
Y+EE+ +IK+ K++ L D+E Q L ++++ + +LE+ T+++ +
Sbjct: 699 FYEEELSKREGIHANEIKNLKKE--LHDSEGQQLA---LNKEIMILKDKLEK-TRRESQS 752
Query: 288 EGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEK 347
E + K + + E L N++L EL++ + ++ + L++E L +K
Sbjct: 753 EREEFESEF-KQQYEREKVLLTEENKKLTSELDKLTTLYENLSIHNQQLEEEVKDLADKK 811
Query: 348 EMEVY---RVTESLQ 359
E + ++TE +Q
Sbjct: 812 ESVAHWEAQITEIIQ 826
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 57.0 bits (136), Expect = 3e-08
Identities = 58/211 (27%), Positives = 103/211 (48%), Gaps = 29/211 (13%)
Query: 151 DMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKE---EPHLLSNFEDFLTRIISQ 207
+ GE++ + +D + + ++D ++V Q+ L K+ EPH LS + L ++
Sbjct: 358 EQGEEDSYDLKGRLDDIRME--MDDFNEVFQILLNTVKDSKAEPHFLSILQHLL--LVRN 413
Query: 208 LQEAHEEKNEL--EC----ALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKD-TERFQ 260
EA + +L EC L + A D + +HL E+E I +Q + K E+ +
Sbjct: 414 DYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQIEIEGLI----DQMIDKTKVEKSE 469
Query: 261 ARSQELEQKL---LCKEQELE--------QLTQKQKRLEGQCTALHHDKHETKAENTKLK 309
A++ ELE+KL L EL+ QK + L+G+ ALH +K + E L+
Sbjct: 470 AKAAELEKKLDSELTARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATEKQDLE 529
Query: 310 LTNQELARELERTSWELQDAQQQLESLQQEA 340
+L E+ + + EL+DA++++ SL A
Sbjct: 530 AEVSQLTGEVAKLTKELEDAKKEMASLSAAA 560
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,983,171
Number of Sequences: 37866
Number of extensions: 792686
Number of successful extensions: 10566
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 409
Number of HSP's successfully gapped in prelim test: 988
Number of HSP's that attempted gapping in prelim test: 4399
Number of HSP's gapped (non-prelim): 4180
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.