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Search of human proteins with 14249174
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14249174 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 8 [Homo sapiens]
(440 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14249174 pleckstrin homology domain containing, family A (pho... 886 0.0
gi|7705684 pleckstrin homology domain containing, family A (phos... 610 e-174
gi|54792084 pleckstrin homology domain containing, family A (pho... 259 4e-69
gi|4505531 oxysterol binding protein [Homo sapiens] 88 1e-17
gi|22547173 oxysterol binding protein-like 9 isoform d [Homo sap... 84 3e-16
gi|14165452 alpha 3 type IV collagen binding protein isoform 2 [... 82 1e-15
gi|194294543 alpha 3 type IV collagen binding protein isoform 3 ... 82 1e-15
gi|5031717 alpha 3 type IV collagen binding protein isoform 1 [H... 82 1e-15
gi|20070331 oxysterol binding protein-like 9 isoform e [Homo sap... 79 8e-15
gi|7705987 glycolipid transfer protein [Homo sapiens] 79 1e-14
gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens] 78 1e-14
gi|22547176 oxysterol binding protein-like 9 isoform f [Homo sap... 75 1e-13
gi|29788755 SET binding factor 2 [Homo sapiens] 50 4e-06
gi|217416392 pleckstrin homology domain containing, family H (wi... 49 7e-06
gi|19923592 oxysterol binding protein-like 11 [Homo sapiens] 47 3e-05
gi|19923812 oxysterol-binding protein-like protein 10 [Homo sapi... 47 4e-05
gi|55741447 pleckstrin homology domain containing, family H (wit... 42 8e-04
gi|239735519 SET binding factor 1 [Homo sapiens] 39 0.009
gi|154354979 myosin X [Homo sapiens] 39 0.009
gi|93102364 SWAP-70 protein [Homo sapiens] 38 0.016
gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo sa... 38 0.016
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 37 0.027
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 37 0.027
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 37 0.027
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 37 0.027
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 36 0.061
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 36 0.061
gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens] 36 0.061
gi|4502023 AKT2 kinase [Homo sapiens] 36 0.079
gi|22035612 oxysterol-binding protein-like protein 6 isoform b [... 36 0.079
>gi|14249174 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 8 [Homo
sapiens]
Length = 440
Score = 886 bits (2289), Expect = 0.0
Identities = 440/440 (100%), Positives = 440/440 (100%)
Query: 1 MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR 60
MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR
Sbjct: 1 MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR 60
Query: 61 MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSEL 120
MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSEL
Sbjct: 61 MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSEL 120
Query: 121 RLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSE 180
RLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSE
Sbjct: 121 RLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSE 180
Query: 181 LLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNK 240
LLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNK
Sbjct: 181 LLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEILMKNK 240
Query: 241 NSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECL 300
NSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECL
Sbjct: 241 NSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCSPECL 300
Query: 301 WEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMD 360
WEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMD
Sbjct: 301 WEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMD 360
Query: 361 LVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLT 420
LVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLT
Sbjct: 361 LVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLKGFLT 420
Query: 421 EVKNGEKDIQTALRNPTENT 440
EVKNGEKDIQTALRNPTENT
Sbjct: 421 EVKNGEKDIQTALRNPTENT 440
>gi|7705684 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 9 [Homo
sapiens]
Length = 391
Score = 610 bits (1572), Expect = e-174
Identities = 310/319 (97%), Positives = 311/319 (97%)
Query: 117 MSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAA 176
MSELRL CDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAA
Sbjct: 1 MSELRLCCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAA 60
Query: 177 FTSELLYRTPPGSPQLAMLKSSKMKHPIIPIHNSLERQMELSTCENGSLNMEINGEEEIL 236
FTSELLY TPPGSPQLAMLKSSKMKHPIIPIHNSLERQ ELSTCENGSLNMEINGEEEIL
Sbjct: 61 FTSELLYHTPPGSPQLAMLKSSKMKHPIIPIHNSLERQTELSTCENGSLNMEINGEEEIL 120
Query: 237 MKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDNNLTQSGSDSSCS 296
MKNKNSLYLKSAEIDCSISSEENTDDNITVQGEI KED MENLKNHDNNL+QSGSDSSCS
Sbjct: 121 MKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIMKEDRMENLKNHDNNLSQSGSDSSCS 180
Query: 297 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCYAVVPVLDKLGPTVFAP 356
PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASC AVVPVLDKLGPTVFAP
Sbjct: 181 PECLWEEGKEVIPTFFSTMNTSFSDIELLEDSGIPTEAFLASCCAVVPVLDKLGPTVFAP 240
Query: 357 VKMDLVGNIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLK 416
VKMDLV NIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLK
Sbjct: 241 VKMDLVENIKKVNQKYITNKEEFTTLQKIVLHEVEADVAQVRNSATEALLWLKRGLKFLK 300
Query: 417 GFLTEVKNGEKDIQTALRN 435
GFLTEVKNGEKDIQTAL N
Sbjct: 301 GFLTEVKNGEKDIQTALNN 319
>gi|54792084 pleckstrin homology domain containing, family A
(phosphoinositide binding specific) member 3 [Homo
sapiens]
Length = 300
Score = 259 bits (661), Expect = 4e-69
Identities = 130/213 (61%), Positives = 158/213 (74%), Gaps = 10/213 (4%)
Query: 1 MEGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR 60
MEGVLYKWTNYL+GWQPRWF+L GILSYYDS +D KG KGSI+MAVCEI+VHS DNTR
Sbjct: 1 MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTR 60
Query: 61 MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSEL 120
M+LIIPGEQ+FY+KA + AERQRWLVALGS+KACLTD+RT+KEKE +E +E+LKTKMSEL
Sbjct: 61 MELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSEL 120
Query: 121 RLYCDLLVQQVDKTKEVTTTGVSNS----EEGIDVGTLLKSTCNTFLKTLEECMQIANAA 176
RLYCDLL+QQV +E ++S E + +LL +TCNTF+ TLEEC++IANA
Sbjct: 121 RLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAK 180
Query: 177 FTSELLY------RTPPGSPQLAMLKSSKMKHP 203
F E+ P SP + + HP
Sbjct: 181 FKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHP 213
>gi|4505531 oxysterol binding protein [Homo sapiens]
Length = 807
Score = 88.2 bits (217), Expect = 1e-17
Identities = 61/194 (31%), Positives = 95/194 (48%), Gaps = 24/194 (12%)
Query: 2 EGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRM 61
EG L+KWTNY+ G+Q RWF+L G+LSYY S + C+G+I +A I V D+
Sbjct: 92 EGWLFKWTNYIKGYQRRWFVLSNGLLSYYRSKAEMRHTCRGTINLATANITVE--DSCNF 149
Query: 62 DLIIPGEQYFYLKARSVAERQRWLVALGSAKACLT------------DSRTQKEKEFAEN 109
+ G Q ++LKA S ERQRW+ AL AKA +S +Q +K +N
Sbjct: 150 IISNGGAQTYHLKASSEVERQRWVTALELAKAKAVKMLAESDESGDEESVSQTDKTELQN 209
Query: 110 T-ENLKTKMSELRLYCDL-------LVQQVDKTKEVTTTGVSNS--EEGIDVGTLLKSTC 159
T L +K+ +L DL L + + + + + SN ++ + TL + T
Sbjct: 210 TLRTLSSKVEDLSTCNDLIAKHGTALQRSLSELESLKLPAESNEKIKQVNERATLFRITS 269
Query: 160 NTFLKTLEECMQIA 173
N + + + +A
Sbjct: 270 NAMINACRDFLMLA 283
>gi|22547173 oxysterol binding protein-like 9 isoform d [Homo
sapiens]
Length = 723
Score = 84.0 bits (206), Expect = 3e-16
Identities = 56/210 (26%), Positives = 105/210 (50%), Gaps = 10/210 (4%)
Query: 1 MEGVLYKWTNYLSGWQPRWFLL--CGGILSYYDSPEDAWKGC-KGSIQMAVCEIQVHSVD 57
MEG L KWTN + GWQ RWF+L G+LSYY S + +G +G +++ I + D
Sbjct: 5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 58 NTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKM 117
++ + + ++ F+ +AR ER++W+ AL T + F + ++ K+
Sbjct: 65 DSTFTITV-DQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKL 123
Query: 118 SELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEEC---MQIAN 174
+E Y +L++Q+ K + E+ + T LK T N+ +++++ C +QIA
Sbjct: 124 TEADAYLQILIEQL-KLFDDKLQNCKEDEQRKKIET-LKETTNSMVESIKHCIVLLQIAK 181
Query: 175 AAFTS-ELLYRTPPGSPQLAMLKSSKMKHP 203
+ + +Y+ P P ++ + S + P
Sbjct: 182 STINPVDAIYQPSPLEPVISTMPSQTVLPP 211
>gi|14165452 alpha 3 type IV collagen binding protein isoform 2
[Homo sapiens]
Length = 598
Score = 81.6 bits (200), Expect = 1e-15
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 27/153 (17%)
Query: 3 GVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMD 62
GVL KWTNY+ GWQ RW +L LSYY S ++ GC+GSI ++ I H D R D
Sbjct: 28 GVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFD 87
Query: 63 LIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFA--------------- 107
+ + + +YL+A+ RQ+W+ A+ K T+S E
Sbjct: 88 ISV-NDSVWYLRAQDPDHRQQWIDAIEQHK---TESGYGSESSLRRHGSMVSLVSGASGY 143
Query: 108 --------ENTENLKTKMSELRLYCDLLVQQVD 132
+ +L+ K++E+ + D+L +QVD
Sbjct: 144 SATSTSSFKKGHSLREKLAEMETFRDILCRQVD 176
>gi|194294543 alpha 3 type IV collagen binding protein isoform 3
[Homo sapiens]
Length = 752
Score = 81.6 bits (200), Expect = 1e-15
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 27/153 (17%)
Query: 3 GVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMD 62
GVL KWTNY+ GWQ RW +L LSYY S ++ GC+GSI ++ I H D R D
Sbjct: 156 GVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFD 215
Query: 63 LIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFA--------------- 107
+ + + +YL+A+ RQ+W+ A+ K T+S E
Sbjct: 216 ISV-NDSVWYLRAQDPDHRQQWIDAIEQHK---TESGYGSESSLRRHGSMVSLVSGASGY 271
Query: 108 --------ENTENLKTKMSELRLYCDLLVQQVD 132
+ +L+ K++E+ + D+L +QVD
Sbjct: 272 SATSTSSFKKGHSLREKLAEMETFRDILCRQVD 304
>gi|5031717 alpha 3 type IV collagen binding protein isoform 1 [Homo
sapiens]
Length = 624
Score = 81.6 bits (200), Expect = 1e-15
Identities = 48/153 (31%), Positives = 74/153 (48%), Gaps = 27/153 (17%)
Query: 3 GVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMD 62
GVL KWTNY+ GWQ RW +L LSYY S ++ GC+GSI ++ I H D R D
Sbjct: 28 GVLSKWTNYIHGWQDRWVVLKNNALSYYKSEDETEYGCRGSICLSKAVITPHDFDECRFD 87
Query: 63 LIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFA--------------- 107
+ + + +YL+A+ RQ+W+ A+ K T+S E
Sbjct: 88 ISV-NDSVWYLRAQDPDHRQQWIDAIEQHK---TESGYGSESSLRRHGSMVSLVSGASGY 143
Query: 108 --------ENTENLKTKMSELRLYCDLLVQQVD 132
+ +L+ K++E+ + D+L +QVD
Sbjct: 144 SATSTSSFKKGHSLREKLAEMETFRDILCRQVD 176
>gi|20070331 oxysterol binding protein-like 9 isoform e [Homo
sapiens]
Length = 736
Score = 79.0 bits (193), Expect = 8e-15
Identities = 49/179 (27%), Positives = 91/179 (50%), Gaps = 6/179 (3%)
Query: 1 MEGVLYKWTNYLSGWQPRWFLL--CGGILSYYDSPEDAWKGC-KGSIQMAVCEIQVHSVD 57
MEG L KWTN + GWQ RWF+L G+LSYY S + +G +G +++ I + D
Sbjct: 5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 58 NTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKM 117
++ + + ++ F+ +AR ER++W+ AL T + F + ++ K+
Sbjct: 65 DSTFTITV-DQKTFHFQARDADEREKWIHALEETILRHTLQLQGLDSGFVPSVQDFDKKL 123
Query: 118 SELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAA 176
+E Y +L++Q+ K + E+ + T LK T N+ +++++ C+ + A
Sbjct: 124 TEADAYLQILIEQL-KLFDDKLQNCKEDEQRKKIET-LKETTNSMVESIKHCIVLLQIA 180
>gi|7705987 glycolipid transfer protein [Homo sapiens]
Length = 209
Score = 78.6 bits (192), Expect = 1e-14
Identities = 45/103 (43%), Positives = 61/103 (59%), Gaps = 1/103 (0%)
Query: 327 DSGIPTEAFLASCYAVVPVLDKLGPTVFAPVKMDLVGNIKKVNQKYITNKEEFTTLQKIV 386
D I T FL + + P D LG VF P+K D+ GNI K+ Y TN +F TLQ I+
Sbjct: 15 DKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNIL 74
Query: 387 LHEVEADVAQ-VRNSATEALLWLKRGLKFLKGFLTEVKNGEKD 428
E E A+ + AT AL+WLKRGL+F++ FL + +GE+D
Sbjct: 75 EVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERD 117
>gi|13540513 oxysterol binding protein 2 isoform a [Homo sapiens]
Length = 916
Score = 78.2 bits (191), Expect = 1e-14
Identities = 58/196 (29%), Positives = 94/196 (47%), Gaps = 27/196 (13%)
Query: 2 EGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRM 61
EG L KWTNYL G+Q RWF+L G+LSYY + + C+G+I ++ I +++
Sbjct: 186 EGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHI---DTEDSCG 242
Query: 62 DLIIPGEQYFYLKARSVAERQRWLVALGSAKACLT--------------DSRTQKEK-EF 106
L+ G + ++LKA S +RQ+W+ AL AKA ++ T +K E
Sbjct: 243 ILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSEL 302
Query: 107 AENTENLKTKMSELRLYCDLLVQQVDKTKEVTT--TGV---SNSEEGIDV----GTLLKS 157
+NL K+ +L DL+ + + T G+ S S E + V TL +
Sbjct: 303 HHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRI 362
Query: 158 TCNTFLKTLEECMQIA 173
T N + + +++A
Sbjct: 363 TSNAMINACRDFLELA 378
>gi|22547176 oxysterol binding protein-like 9 isoform f [Homo
sapiens]
Length = 746
Score = 75.1 bits (183), Expect = 1e-13
Identities = 58/233 (24%), Positives = 109/233 (46%), Gaps = 33/233 (14%)
Query: 1 MEGVLYKWTNYLSGWQPRWFLL--CGGILSYYDSPEDAWKGC-KGSIQMAVCEIQVHSVD 57
MEG L KWTN + GWQ RWF+L G+LSYY S + +G +G +++ I + D
Sbjct: 5 MEGPLSKWTNVMKGWQYRWFVLDYNAGLLSYYTSKDKMMRGSRRGCVRLRGAVIGIDDED 64
Query: 58 NTRMDLIIPGEQYFYLKARSVAERQRWLVAL-------------GSAKACLTDSRTQKEK 104
++ + + ++ F+ +AR ER++W+ AL + A S
Sbjct: 65 DSTFTITV-DQKTFHFQARDADEREKWIHALEETILRHTLQLQISTTLAFFQSSGISPVL 123
Query: 105 EFAE----------NTENLKTKMSELRLYCDLLVQQVDKTKEVTTTGVSNSEEGIDVGTL 154
EF++ + ++ K++E Y +L++Q+ K + E+ + T
Sbjct: 124 EFSKIIGLDSGFVPSVQDFDKKLTEADAYLQILIEQL-KLFDDKLQNCKEDEQRKKIET- 181
Query: 155 LKSTCNTFLKTLEEC---MQIANAAFTS-ELLYRTPPGSPQLAMLKSSKMKHP 203
LK T N+ +++++ C +QIA + + +Y+ P P ++ + S + P
Sbjct: 182 LKETTNSMVESIKHCIVLLQIAKSTINPVDAIYQPSPLEPVISTMPSQTVLPP 234
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 50.1 bits (118), Expect = 4e-06
Identities = 36/109 (33%), Positives = 51/109 (46%), Gaps = 18/109 (16%)
Query: 2 EGVLYKWTNYLSGWQPRWFLL--CGGILSYYDSPEDAWKGCKGSIQMAVCEIQV------ 53
EG LYK L GW+PRWF+L L YYDS ED CKG I +A E+ +
Sbjct: 1747 EGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDT--SCKGHIDLAEVEMVIPAGPSM 1804
Query: 54 ----HSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDS 98
H+ D DL Y + A+ Q+W + ++C++D+
Sbjct: 1805 GAPKHTSDKAFFDLKTSKRVYNFC-AQDGQSAQQW---MDKIQSCISDA 1849
>gi|217416392 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 2 [Homo sapiens]
Length = 1493
Score = 49.3 bits (116), Expect = 7e-06
Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 4/128 (3%)
Query: 3 GVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMD 62
G L K + + W+ RWF+L GG L YY SP D + +G I+++ + DN +
Sbjct: 708 GYLLKMSGKVKSWKRRWFVLKGGELLYYKSPSDVIRKPQGHIELS-ASCSILRGDNKQTV 766
Query: 63 LIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMS---E 119
+ + +YL A S + W+ L + + + E + L TK+
Sbjct: 767 QLTTEKHTYYLTADSPNILEEWIKVLQNVLRVQAANPLSLQPEGKPTMKGLLTKVKHGYS 826
Query: 120 LRLYCDLL 127
R++C L+
Sbjct: 827 KRVWCTLI 834
>gi|19923592 oxysterol binding protein-like 11 [Homo sapiens]
Length = 747
Score = 47.0 bits (110), Expect = 3e-05
Identities = 26/88 (29%), Positives = 46/88 (52%), Gaps = 2/88 (2%)
Query: 3 GVLYKWTNYLSGWQPRWFLLC--GGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTR 60
G L K+TN ++GWQ R+F+L G+L Y+ + + + +G++Q+A I D+
Sbjct: 63 GYLMKYTNLVTGWQYRFFVLNNEAGLLEYFVNEQSRNQKPRGTLQLAGAVISPSDEDSHT 122
Query: 61 MDLIIPGEQYFYLKARSVAERQRWLVAL 88
+ + + L+A ERQ W+ L
Sbjct: 123 FTVNAASGEQYKLRATDAKERQHWVSRL 150
>gi|19923812 oxysterol-binding protein-like protein 10 [Homo
sapiens]
Length = 764
Score = 46.6 bits (109), Expect = 4e-05
Identities = 28/96 (29%), Positives = 49/96 (51%), Gaps = 5/96 (5%)
Query: 1 MEGVLYKWTNYLSGWQPRWFLLC--GGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDN 58
+EGVL K+TN L GWQ R+F+L GIL Y+ + + + +G + ++ + +
Sbjct: 77 LEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAP 136
Query: 59 TRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKAC 94
+ + + F L+A E+Q W+ L +AC
Sbjct: 137 HMLVVYSANGEMFKLRAADAKEKQFWVTQL---RAC 169
>gi|55741447 pleckstrin homology domain containing, family H (with
MyTH4 domain) member 1 [Homo sapiens]
Length = 1364
Score = 42.4 bits (98), Expect = 8e-04
Identities = 24/88 (27%), Positives = 44/88 (50%), Gaps = 1/88 (1%)
Query: 3 GVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMD 62
G L K + + W+ RWF+L G + YY SP D + +G + + Q+ + ++
Sbjct: 583 GYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDLN-SRCQIVRGEGSQTF 641
Query: 63 LIIPGEQYFYLKARSVAERQRWLVALGS 90
+I ++ +YL A S + + W+ L S
Sbjct: 642 QLISEKKTYYLTADSPSLLEEWIRVLQS 669
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 38.9 bits (89), Expect = 0.009
Identities = 30/108 (27%), Positives = 47/108 (43%), Gaps = 16/108 (14%)
Query: 2 EGVLYKWTNYLSGWQPRWFLL--CGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNT 59
EG LYK ++ W+ RWF+L L YYD D CKG I +A E
Sbjct: 1791 EGTLYKKGAFMKPWKARWFVLDKTKHQLRYYDHRVDT--ECKGVIDLAEVEAVAPGTPTM 1848
Query: 60 RMDLIIPGEQYFYLK---------ARSVAERQRWLVALGSAKACLTDS 98
+ + +F +K A+ V Q+W+ + ++CL+D+
Sbjct: 1849 GAPKTVDEKAFFDVKTTRRVYNFCAQDVPSAQQWVDRI---QSCLSDA 1893
>gi|154354979 myosin X [Homo sapiens]
Length = 2058
Score = 38.9 bits (89), Expect = 0.009
Identities = 27/101 (26%), Positives = 49/101 (48%), Gaps = 9/101 (8%)
Query: 15 WQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDL---IIPGEQYF 71
W+ RWF+L L Y+++ D+ + KG++++ + +DNT + II ++ F
Sbjct: 1234 WKKRWFVLRQSKLMYFEN--DSEEKLKGTVEVRTAK---EIIDNTTKENGIDIIMADRTF 1288
Query: 72 YLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTEN 112
+L A S + +W L A TD Q+ + N +N
Sbjct: 1289 HLIAESPEDASQWFSVLSQVHAS-TDQEIQEMHDEQANPQN 1328
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 38.1 bits (87), Expect = 0.016
Identities = 46/202 (22%), Positives = 87/202 (43%), Gaps = 25/202 (12%)
Query: 2 EGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQM--AVCEIQVHSVDNT 59
+G + K + W RWF+L I+SYY S + K KG I + C + D
Sbjct: 214 QGYMMKKGHRRKNWTERWFVLKPNIISYYVSED--LKDKKGDILLDENCCVESLPDKDGK 271
Query: 60 R-MDLIIPGEQYFYLKARSVAERQRWLVALGSA------------KACLTDSRTQKEKEF 106
+ + L+ ++ F + A ++Q W+ A+ S K + ++K+
Sbjct: 272 KCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQL 331
Query: 107 AENTENLKTKMSELRLYCDLLVQQVD----KTKEVTTTGVSNSEEGIDVGTLLKSTCNTF 162
AE E L+ +M EL+ + Q+++ K +E + ++ + L++ +T
Sbjct: 332 AEQ-EELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTE 390
Query: 163 L---KTLEECMQIANAAFTSEL 181
L K + + M+ A +SEL
Sbjct: 391 LEREKLIRQQMEEQVAQKSSEL 412
>gi|19718741 oxysterol-binding protein-like 1A isoform B [Homo
sapiens]
Length = 950
Score = 38.1 bits (87), Expect = 0.016
Identities = 36/136 (26%), Positives = 58/136 (42%), Gaps = 27/136 (19%)
Query: 2 EGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDA-----WKGCKGSIQMAVCEIQ---- 52
EG L+K + + GW+ W +L G+LS+Y DA +GCK + AVC ++
Sbjct: 239 EGPLWKSSRFF-GWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCK-HLTQAVCTVKSTDS 296
Query: 53 ----VHSVDNTRMDLIIPGEQYFYLKARSVAERQRWLVALGSAKA-----CLTDSRTQKE 103
+ D+T +P K R+ WL A+ A C D T +E
Sbjct: 297 CLFFIKCFDDTIHGFRVP-------KNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEE 349
Query: 104 KEFAENTENLKTKMSE 119
+E + +LK + +
Sbjct: 350 EEDTVSAADLKKSLEK 365
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 37.4 bits (85), Expect = 0.027
Identities = 35/141 (24%), Positives = 59/141 (41%), Gaps = 8/141 (5%)
Query: 2 EGVLYKWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKGCKGSIQM-AVCEIQV-HSVDNT 59
+G L+K + W RWF L L Y+ S E K +G I + A C ++V D
Sbjct: 220 QGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEE--CKEKRGIIPLDAHCCVEVLPDRDGK 277
Query: 60 R-MDLIIPGEQYFYLKARSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMS 118
R M + + + + A +RQ W A+ A + +T K+ + + +
Sbjct: 278 RCMFCVKTANRTYEMSASDTRQRQEWTAAIQMAIRLQAEGKTSLHKDLKQKRREQREQRE 337
Query: 119 ELRLYCD---LLVQQVDKTKE 136
R + L +QQ+ + KE
Sbjct: 338 RRRAAKEEELLRLQQLQEEKE 358
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
Length = 1133
Score = 37.4 bits (85), Expect = 0.027
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 15 WQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLK 74
+Q RW L L Y+DS +DA+ K I +A C V ++ + + + +I + F +
Sbjct: 100 YQKRWVRLDTDHLRYFDSNKDAYS--KRFISVA-CISHVAAIGDQKFE-VITNNRTFAFR 155
Query: 75 ARSVAERQRWLVALGSAKA 93
A S ER+ W+ AL A A
Sbjct: 156 AESDVERKEWMQALQQAMA 174
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 37.4 bits (85), Expect = 0.027
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 15 WQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLK 74
+Q RW L L Y+DS +DA+ K I +A C V ++ + + + +I + F +
Sbjct: 100 YQKRWVRLDTDHLRYFDSNKDAYS--KRFISVA-CISHVAAIGDQKFE-VITNNRTFAFR 155
Query: 75 ARSVAERQRWLVALGSAKA 93
A S ER+ W+ AL A A
Sbjct: 156 AESDVERKEWMQALQQAMA 174
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 37.4 bits (85), Expect = 0.027
Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 15 WQPRWFLLCGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNTRMDLIIPGEQYFYLK 74
+Q RW L L Y+DS +DA+ K I +A C V ++ + + + +I + F +
Sbjct: 345 YQKRWVRLDTDHLRYFDSNKDAYS--KRFISVA-CISHVAAIGDQKFE-VITNNRTFAFR 400
Query: 75 ARSVAERQRWLVALGSAKA 93
A S ER+ W+ AL A A
Sbjct: 401 AESDVERKEWMQALQQAMA 419
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 36.2 bits (82), Expect = 0.061
Identities = 61/255 (23%), Positives = 97/255 (38%), Gaps = 50/255 (19%)
Query: 76 RSVAERQRWLVALGSAKACLTDSRTQKEKEFAENTENLKTKMSELRLYCDLLVQQVDKTK 135
R+ E L L + CL D R + E E ++ E + + +E++ D V+ D+ +
Sbjct: 489 RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLD-KVKTADQLQ 547
Query: 136 EVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSELLYRTPPGSPQLAML 195
E G E + L S N K +E + SELL T + + A L
Sbjct: 548 EQLQRGKQEIENLKEEVESLNSLINDLQKDIE-----GSRKRESELLLFTERLTSKNAQL 602
Query: 196 KSSKMKHPIIPIHNSLERQMELSTCENGSLNME--------INGEEEILMK---NKNSLY 244
+S NSL+ Q + +C L + IN E +L + K +
Sbjct: 603 QSES---------NSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQ 653
Query: 245 LKSAEIDC--------SISSEENTDDNIT---------------VQGEIRKEDGMENLKN 281
AE+ C S EE D+ +T +Q RK D +E+ +
Sbjct: 654 TLQAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVES-GS 712
Query: 282 HDNNLTQSGSDSSCS 296
+D ++ GS SS S
Sbjct: 713 YDKEVSSMGSRSSSS 727
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 36.2 bits (82), Expect = 0.061
Identities = 54/242 (22%), Positives = 100/242 (41%), Gaps = 30/242 (12%)
Query: 76 RSVAERQRWLVALGSAKACLTDSRTQKEK-----------EFAENTENLKTKMSELRLYC 124
RS+ E Q + S K L KEK + AE+TE + K EL+
Sbjct: 1557 RSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTE-WQEKHKELQKEY 1615
Query: 125 DLLVQQVD----KTKEVTTTGVSNSEEGIDVGTLLKSTCNTFLKTLEECMQIANAAFTSE 180
++L+Q + + + + + +E ++ L+ST +T ++ + +
Sbjct: 1616 EILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK 1675
Query: 181 LLYRTPPGSPQLAMLK----SSKMKHPIIPIHNSLERQMELSTCENGSLNMEING---EE 233
R S Q +L+ + +++ + P ++ + ME N S+ E+ E
Sbjct: 1676 EKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEY 1735
Query: 234 EILMKNKNSLYLKSAEIDCSISSEENTDDNITVQGEIRKEDGMENLKNHDN--NLTQSGS 291
E L K SL + + SEE D ++G + K+ +E + HDN N+T+ G+
Sbjct: 1736 ETLSKKFQSLMSEKDSL-----SEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790
Query: 292 DS 293
S
Sbjct: 1791 QS 1792
>gi|22035616 oxysterol-binding protein-like protein 7 [Homo sapiens]
Length = 842
Score = 36.2 bits (82), Expect = 0.061
Identities = 27/83 (32%), Positives = 42/83 (50%), Gaps = 5/83 (6%)
Query: 7 KWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKG-CKGSIQMAVCEIQVHSVDNTRMDLII 65
KW L GW R+F+L GIL Y + +D KG GSI + + + ++ R+DL
Sbjct: 59 KWP--LKGWHKRYFVLEDGILHYATTRQDITKGKLHGSIDVRLSVMSINK-KAQRIDLDT 115
Query: 66 PGEQYFYLKARSVAERQRWLVAL 88
+ ++LK +S Q W+ L
Sbjct: 116 E-DNIYHLKIKSQDLFQSWVAQL 137
>gi|4502023 AKT2 kinase [Homo sapiens]
Length = 481
Score = 35.8 bits (81), Expect = 0.079
Identities = 35/145 (24%), Positives = 58/145 (40%), Gaps = 29/145 (20%)
Query: 2 EGVLYKWTNYLSGWQPRWFLL--CGGILSYYDSPEDAWKGCKGSIQMAVCEIQVHSVDNT 59
EG L+K Y+ W+PR+FLL G + Y + PE + +V E Q+ +
Sbjct: 9 EGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERP 68
Query: 60 RMDLIIPG--------EQYFYLKARSVAERQRWLVALGSAKACL---------------- 95
R + + E+ F++ S ER+ W+ A+ L
Sbjct: 69 RPNTFVIRCLQWTTVIERTFHVD--SPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGS 126
Query: 96 -TDSRTQKEKEFAENTENLKTKMSE 119
+DS T +E E A + K M++
Sbjct: 127 PSDSSTTEEMEVAVSKARAKVTMND 151
>gi|22035612 oxysterol-binding protein-like protein 6 isoform b
[Homo sapiens]
Length = 938
Score = 35.8 bits (81), Expect = 0.079
Identities = 27/83 (32%), Positives = 40/83 (48%), Gaps = 5/83 (6%)
Query: 7 KWTNYLSGWQPRWFLLCGGILSYYDSPEDAWKG-CKGSIQMAVCEIQVHSVDNTRMDLII 65
KW L GW R+F+L G+L Y +P D KG GSI + + + + R+DL
Sbjct: 77 KWP--LKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKK-KARRIDLDT 133
Query: 66 PGEQYFYLKARSVAERQRWLVAL 88
E ++LK +S W+ L
Sbjct: 134 E-EHIYHLKVKSQDWFDAWVSKL 155
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,265,467
Number of Sequences: 37866
Number of extensions: 686955
Number of successful extensions: 1851
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 68
Number of HSP's that attempted gapping in prelim test: 1784
Number of HSP's gapped (non-prelim): 115
length of query: 440
length of database: 18,247,518
effective HSP length: 105
effective length of query: 335
effective length of database: 14,271,588
effective search space: 4780981980
effective search space used: 4780981980
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.