Guide to the Human Genome
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Search of human proteins with 9998946

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
sapiens]
         (549 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo ...  1139   0.0  
gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo ...  1050   0.0  
gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo ...  1014   0.0  
gi|9998944 amiloride-sensitive cation channel 1, neuronal isofor...   517   e-147
gi|21536349 amiloride-sensitive cation channel 2, neuronal isofo...   507   e-143
gi|21536351 amiloride-sensitive cation channel 2, neuronal isofo...   485   e-137
gi|34452695 amiloride-sensitive cation channel 1, neuronal isofo...   472   e-133
gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo...   447   e-125
gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo...   423   e-118
gi|31442761 amiloride-sensitive cation channel 5, intestinal [Ho...   224   1e-58
gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2 ...   143   4e-34
gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3 ...   143   4e-34
gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [H...   143   4e-34
gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo sapi...   123   5e-28
gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo sapi...   107   2e-23
gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2 ...   102   9e-22
gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1...   102   9e-22
gi|39930351 dynamin binding protein [Homo sapiens]                     36   0.080
gi|55741655 anoctamin 8 [Homo sapiens]                                 36   0.10 
gi|157168329 formin 1 [Homo sapiens]                                   34   0.30 
gi|161019170 mucin 5AC [Homo sapiens]                                  34   0.30 
gi|38201621 eukaryotic translation initiation factor 4 gamma, 1 ...    34   0.30 
gi|38201627 eukaryotic translation initiation factor 4 gamma, 1 ...    34   0.30 
gi|38201625 eukaryotic translation initiation factor 4 gamma, 1 ...    34   0.30 
gi|38201623 eukaryotic translation initiation factor 4 gamma, 1 ...    34   0.30 
gi|38201619 eukaryotic translation initiation factor 4 gamma, 1 ...    34   0.30 
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]       34   0.30 
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    33   0.68 
gi|120952764 mastermind-like domain containing 1 [Homo sapiens]        33   0.88 
gi|47132519 Ras association and pleckstrin homology domains 1 is...    33   0.88 

>gi|9998946 amiloride-sensitive cation channel 3 isoform b [Homo
           sapiens]
          Length = 549

 Score = 1139 bits (2945), Expect = 0.0
 Identities = 549/549 (100%), Positives = 549/549 (100%)

Query: 1   MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV 60
           MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV
Sbjct: 1   MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV 60

Query: 61  AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA 120
           AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA
Sbjct: 61  AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA 120

Query: 121 EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF 180
           EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF
Sbjct: 121 EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF 180

Query: 181 TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ 240
           TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ
Sbjct: 181 TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ 240

Query: 241 IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG 300
           IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG
Sbjct: 241 IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG 300

Query: 301 SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR 360
           SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR
Sbjct: 301 SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR 360

Query: 361 KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY 420
           KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY
Sbjct: 361 KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY 420

Query: 421 ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR 480
           ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR
Sbjct: 421 ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR 480

Query: 481 HSSTNLLQEGLGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP 540
           HSSTNLLQEGLGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP
Sbjct: 481 HSSTNLLQEGLGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP 540

Query: 541 AVCVLGAPP 549
           AVCVLGAPP
Sbjct: 541 AVCVLGAPP 549


>gi|4757710 amiloride-sensitive cation channel 3 isoform a [Homo
           sapiens]
          Length = 531

 Score = 1050 bits (2714), Expect = 0.0
 Identities = 515/544 (94%), Positives = 516/544 (94%), Gaps = 16/544 (2%)

Query: 1   MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV 60
           MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV
Sbjct: 1   MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV 60

Query: 61  AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA 120
           AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA
Sbjct: 61  AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA 120

Query: 121 EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF 180
           EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF
Sbjct: 121 EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF 180

Query: 181 TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ 240
           TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ
Sbjct: 181 TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ 240

Query: 241 IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG 300
           IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG
Sbjct: 241 IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG 300

Query: 301 SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR 360
           SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR
Sbjct: 301 SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR 360

Query: 361 KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY 420
           KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY
Sbjct: 361 KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY 420

Query: 421 ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR 480
           ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR
Sbjct: 421 ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR 480

Query: 481 HSSTNLLQEGLGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP 540
           HSSTNLLQEGLGSHRTQVPHLSLGP         PP        +PP     TLS S R 
Sbjct: 481 HSSTNLLQEGLGSHRTQVPHLSLGPR--------PP--------TPPCAVTKTLSASHRT 524

Query: 541 AVCV 544
              V
Sbjct: 525 CYLV 528


>gi|9998948 amiloride-sensitive cation channel 3 isoform c [Homo
           sapiens]
          Length = 543

 Score = 1014 bits (2621), Expect = 0.0
 Identities = 504/548 (91%), Positives = 507/548 (92%), Gaps = 19/548 (3%)

Query: 1   MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV 60
           MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV
Sbjct: 1   MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV 60

Query: 61  AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA 120
           AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA
Sbjct: 61  AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA 120

Query: 121 EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF 180
           EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF
Sbjct: 121 EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF 180

Query: 181 TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ 240
           TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ
Sbjct: 181 TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ 240

Query: 241 IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG 300
           IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG
Sbjct: 241 IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG 300

Query: 301 SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR 360
           SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR
Sbjct: 301 SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR 360

Query: 361 KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY 420
           KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY
Sbjct: 361 KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY 420

Query: 421 ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR 480
           ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR
Sbjct: 421 ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR 480

Query: 481 HSSTNLLQEGLGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP 540
           HSSTNL      SH +   H           +D   LP   P L P  TA   LS SS P
Sbjct: 481 HSSTNLT-----SHPSLCRH-----------QDSLRLP---PHLLPCHTALDLLSVSSEP 521

Query: 541 AVCVLGAP 548
              +L  P
Sbjct: 522 RPDILDMP 529


>gi|9998944 amiloride-sensitive cation channel 1, neuronal isoform 2
           [Homo sapiens]
          Length = 512

 Score =  517 bits (1332), Expect = e-147
 Identities = 252/504 (50%), Positives = 336/504 (66%), Gaps = 26/504 (5%)

Query: 7   PEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRY 66
           P E     S I++FA+  ++HG+ H+F  G L++RR +WA A V S+   L + +ERV Y
Sbjct: 7   PSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSY 66

Query: 67  YREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAE 121
           Y  + H T +DE  +  L+FPAVTLCN+N  R SRLT NDL+ AG  L  LD     P  
Sbjct: 67  YFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDP 126

Query: 122 HAA---FLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTT 178
           H A    L AL +      + P   F M +   R GH L DM+L C+F+GQ CG ++FTT
Sbjct: 127 HLADPSVLEALRQKANFKHYKPKQ-FSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTT 185

Query: 179 IFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIR 238
           +FT+ GKCY FNSG DG  LLTT +GG GNGL+IMLD+QQ+EYLP+W + EET FE G++
Sbjct: 186 VFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVK 245

Query: 239 VQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDP 298
           VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ +  ++       
Sbjct: 246 VQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDF------- 298

Query: 299 LGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAM 358
                    P Y++  CR+ CETRY+   C CRMV+MPGD P C+P+Q+K CA PA+  +
Sbjct: 299 --------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLL 350

Query: 359 LRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFE 416
             KDS  C C  PC  TRY KELSMV+IPS+ +A++L +K N+SE YI+EN+L LDIFFE
Sbjct: 351 AEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFE 410

Query: 417 ALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQ 476
           ALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ ++K+L      +
Sbjct: 411 ALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEE 470

Query: 477 HSQRHSSTNLLQEGLGSHRTQVPH 500
               H       + + +H   + H
Sbjct: 471 DEGSHDENVSTCDTMPNHSETISH 494


>gi|21536349 amiloride-sensitive cation channel 2, neuronal isoform
           b [Homo sapiens]
          Length = 528

 Score =  507 bits (1305), Expect = e-143
 Identities = 249/462 (53%), Positives = 320/462 (69%), Gaps = 24/462 (5%)

Query: 17  IRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTAL 76
           I+ FAS+ ++HGL H+F    LSL+R +WA   + S+A  L    ERV+YY  +HH T L
Sbjct: 18  IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKL 77

Query: 77  DERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAEHAAF---LRA 128
           DE  + +L FPAVTLCN+N  R S+++ NDL+ AG  L  L+     P    A    L  
Sbjct: 78  DEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEI 137

Query: 129 LGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYT 188
           L        F P P F+M + Y RAGH + DMLL C FRG+ C  E+F  +FTR GKCYT
Sbjct: 138 LQDKANFRSFKPKP-FNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYT 196

Query: 189 FNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPP 248
           FNSG DG   L T +GG GNGL+IMLD+QQ+EYLPVW + +ET FE GI+VQIHSQ+EPP
Sbjct: 197 FNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPP 256

Query: 249 IIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSP 308
            IDQLG GV+PG+QTFV+CQ+Q+L +LPPPWG C + +++ + +   S            
Sbjct: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDS------------ 304

Query: 309 PYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDS--CAC 366
            Y++  CR+ CETRY+   C CRMV+MPGD P C+P+QYK CA PA+D ++ KD   C C
Sbjct: 305 -YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVC 363

Query: 367 PNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQK 426
             PC  TRY KELSMV+IPS+A+A++LA+K N+SE YI EN+L LDIFFE LNYET+EQK
Sbjct: 364 EMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQK 423

Query: 427 KAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKV 468
           KAYE++ LLGDIGGQMGLFIGAS+LT+LE+ DY  EV + K+
Sbjct: 424 KAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKL 465


>gi|21536351 amiloride-sensitive cation channel 2, neuronal isoform
           a [Homo sapiens]
          Length = 574

 Score =  485 bits (1248), Expect = e-137
 Identities = 249/508 (49%), Positives = 320/508 (62%), Gaps = 70/508 (13%)

Query: 17  IRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTAL 76
           I+ FAS+ ++HGL H+F    LSL+R +WA   + S+A  L    ERV+YY  +HH T L
Sbjct: 18  IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKL 77

Query: 77  DERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLD-----PAEHAAF---LRA 128
           DE  + +L FPAVTLCN+N  R S+++ NDL+ AG  L  L+     P    A    L  
Sbjct: 78  DEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEI 137

Query: 129 LGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYT 188
           L        F P P F+M + Y RAGH + DMLL C FRG+ C  E+F  +FTR GKCYT
Sbjct: 138 LQDKANFRSFKPKP-FNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYT 196

Query: 189 FNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPP 248
           FNSG DG   L T +GG GNGL+IMLD+QQ+EYLPVW + +ET FE GI+VQIHSQ+EPP
Sbjct: 197 FNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPP 256

Query: 249 IIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSP 308
            IDQLG GV+PG+QTFV+CQ+Q+L +LPPPWG C + +++ + +   S            
Sbjct: 257 FIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDS------------ 304

Query: 309 PYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDS--CAC 366
            Y++  CR+ CETRY+   C CRMV+MPGD P C+P+QYK CA PA+D ++ KD   C C
Sbjct: 305 -YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVC 363

Query: 367 PNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQK 426
             PC  TRY KELSMV+IPS+A+A++LA+K N+SE YI EN+L LDIFFE LNYET+EQK
Sbjct: 364 EMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQK 423

Query: 427 KAYEMSEL----------------------------------------------LGDIGG 440
           KAYE++ L                                              LGDIGG
Sbjct: 424 KAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDIGG 483

Query: 441 QMGLFIGASLLTILEILDYLCEVFRDKV 468
           QMGLFIGAS+LT+LE+ DY  EV + K+
Sbjct: 484 QMGLFIGASILTVLELFDYAYEVIKHKL 511


>gi|34452695 amiloride-sensitive cation channel 1, neuronal isoform
           1 [Homo sapiens]
          Length = 563

 Score =  472 bits (1215), Expect = e-133
 Identities = 242/515 (46%), Positives = 321/515 (62%), Gaps = 39/515 (7%)

Query: 6   GPEEARRPASDIRVFASNCSMHGLGHVFG----PGSLSLRRGMWAAAVVLSVATFLYQVA 61
           GP  ARR    +    S   +HGL H+       G    RR +W  A   S    L   +
Sbjct: 50  GPGVARRGRPSL----SRAKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSFGLLLSWSS 105

Query: 62  ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
            R+ Y+  F   T +    S +L FPAVT+CN NPLR  RL+  DL++AG  L  L P  
Sbjct: 106 NRLLYWLSFPSHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSKGDLYYAGHWLGLLLPNR 165

Query: 122 HAA-FLRALGRPPAPPG-----------FMPSPTFD--MAQLYARAGHSLDDMLLDCRFR 167
            A   +  L R   P             F+P   F+   A    R GH L+DMLL C++R
Sbjct: 166 TARPLVSELLRGDEPRRQWFRKLADFRLFLPPRHFEGISAAFMDRLGHQLEDMLLSCKYR 225

Query: 168 GQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRD 227
           G+ CGP NF+++FT+ GKCY FNSG DG  LLTT +GG GNGL+IMLD+QQ+EYLP+W +
Sbjct: 226 GELCGPHNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGE 285

Query: 228 NEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASL 287
            EET FE G++VQIHSQ EPP I +LG GV+PG+QTFV+ Q+Q+L++LPPPWG+C S+ +
Sbjct: 286 TEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEM 345

Query: 288 NPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQY 347
             ++                P Y++  CR+ CETRY+   C CRMV+MPGD P C+P+Q+
Sbjct: 346 GLDF---------------FPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQH 390

Query: 348 KNCAHPAIDAMLRKDS--CACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIA 405
           K CA PA+  +  KDS  C C  PC  TRY KELSMV+IPS+ +A++L +K N+SE YI+
Sbjct: 391 KECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYIS 450

Query: 406 ENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFR 465
           EN+L LDIFFEALNYET+EQKKAYE++ LLGDIGGQMGLFIGAS+LTILE+ DY+ E+ +
Sbjct: 451 ENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIK 510

Query: 466 DKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPH 500
           +K+L      +    H       + + +H   + H
Sbjct: 511 EKLLDLLGKEEDEGSHDENVSTCDTMPNHSETISH 545


>gi|33519442 amiloride-sensitive cation channel 4 isoform 1 [Homo
           sapiens]
          Length = 666

 Score =  447 bits (1149), Expect = e-125
 Identities = 244/493 (49%), Positives = 303/493 (61%), Gaps = 28/493 (5%)

Query: 16  DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75
           D+  FAS  ++HGLG   GPG   LRR +WA A++ S+A FLYQ A   R Y    H  A
Sbjct: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227

Query: 76  LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134
           +D      +  FPAVTLCNIN  R S L+  D+    + L GL P +      A  R P 
Sbjct: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286

Query: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194
           P         DM  +  R GH L DML  C F G  C   NF+ ++TR GKCYTFN  AD
Sbjct: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335

Query: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254
               L +  GGMG+GL+IMLD+QQEEYLP+WR+  ET FE GIRVQIHSQEEPP I QLG
Sbjct: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395

Query: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314
            GVSPG+QTFVSCQ+Q+L++LP PWG+C + S            L  P       Y++  
Sbjct: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444

Query: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR--KDSCACPNPCAS 372
           CRL CE   V ++C CRMV+MPG+  +C P  Y  CA   +D++    +  C CP PC  
Sbjct: 445 CRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIECADHTLDSLGGGPEGPCFCPTPCNL 504

Query: 373 TRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMS 432
           TRY KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL  E +EQ+ AY +S
Sbjct: 505 TRYGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLS 564

Query: 433 ELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQE-GL 491
            LLGD+GGQMGLFIGAS+LT+LEILDY+ EV  D+ L   W R  +   +ST  +   GL
Sbjct: 565 ALLGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTSTGGISTLGL 623

Query: 492 GSHRTQVPHLSLG 504
              + Q P  SLG
Sbjct: 624 QELKEQSPCPSLG 636


>gi|33519444 amiloride-sensitive cation channel 4 isoform 2 [Homo
           sapiens]
          Length = 647

 Score =  423 bits (1088), Expect = e-118
 Identities = 238/491 (48%), Positives = 293/491 (59%), Gaps = 43/491 (8%)

Query: 16  DIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTA 75
           D+  FAS  ++HGLG   GPG   LRR +WA A++ S+A FLYQ A   R Y    H  A
Sbjct: 168 DLATFASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFLYQAAGLARGYLTRPHLVA 227

Query: 76  LDERESHRLI-FPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPA 134
           +D      +  FPAVTLCNIN  R S L+  D+    + L GL P +      A  R P 
Sbjct: 228 MDPAAPAPVAGFPAVTLCNINRFRHSALSDADIFHLAN-LTGLPPKDRDGHRAAGLRYPE 286

Query: 135 PPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGAD 194
           P         DM  +  R GH L DML  C F G  C   NF+ ++TR GKCYTFN  AD
Sbjct: 287 P---------DMVDILNRTGHQLADMLKSCNFSGHHCSASNFSVVYTRYGKCYTFN--AD 335

Query: 195 GAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLG 254
               L +  GGMG+GL+IMLD+QQEEYLP+WR+  ET FE GIRVQIHSQEEPP I QLG
Sbjct: 336 PRSSLPSRAGGMGSGLEIMLDIQQEEYLPIWRETNETSFEAGIRVQIHSQEEPPYIHQLG 395

Query: 255 LGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMG 314
            GVSPG+QTFVSCQ+Q+L++LP PWG+C + S            L  P       Y++  
Sbjct: 396 FGVSPGFQTFVSCQEQRLTYLPQPWGNCRAES-----------ELREPELQGYSAYSVSA 444

Query: 315 CRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTR 374
           CRL CE   V ++C CRMV+MP  +    P+                  C CP PC  TR
Sbjct: 445 CRLRCEKEAVLQRCHCRMVHMPDSLGG-GPE----------------GPCFCPTPCNLTR 487

Query: 375 YAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSEL 434
           Y KE+SMVRIP+R +AR+LARK NR+E YI EN L LD+FFEAL  E +EQ+ AY +S L
Sbjct: 488 YGKEISMVRIPNRGSARYLARKYNRNETYIRENFLVLDVFFEALTSEAMEQRAAYGLSAL 547

Query: 435 LGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQE-GLGS 493
           LGD+GGQMGLFIGAS+LT+LEILDY+ EV  D+ L   W R  +   +ST  +   GL  
Sbjct: 548 LGDLGGQMGLFIGASILTLLEILDYIYEVSWDR-LKRVWRRPKTPLRTSTGGISTLGLQE 606

Query: 494 HRTQVPHLSLG 504
            + Q P  SLG
Sbjct: 607 LKEQSPCPSLG 617


>gi|31442761 amiloride-sensitive cation channel 5, intestinal [Homo
           sapiens]
          Length = 505

 Score =  224 bits (572), Expect = 1e-58
 Identities = 147/470 (31%), Positives = 232/470 (49%), Gaps = 39/470 (8%)

Query: 2   KPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVA 61
           KP   P E ++   D   FA + S HG+ ++    S  +RR +W   V+ SV+   +Q+ 
Sbjct: 26  KPLPSPTERKKFDHD---FAISTSFHGIHNIVQNRS-KIRRVLWLVVVLGSVSLVTWQIY 81

Query: 62  ERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAE 121
            R+  Y  +   T+++ +   ++ FPAVT CN+N  +   +    + +    ++      
Sbjct: 82  IRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHL 141

Query: 122 HAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDM-LLDCRFRGQPCGPENFTTIF 180
                 + G   A         F + +     G  L++  LLDC F G+PC P++F  +F
Sbjct: 142 QEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVF 201

Query: 181 TRMGKCYTFNSGADGAELLTTTR--GGMGNGLDIMLDVQQEEYLPVWRDNEETPF-EVGI 237
           T  G C+TFN G    E L   R     G GL ++ +V QE +     DN    F + GI
Sbjct: 202 TEYGNCFTFNHG----ETLQAKRKVSVSGRGLSLLFNVNQEAFT----DNPALGFVDAGI 253

Query: 238 RVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSD 297
              IHS ++ P  D LGL    G    V+ +Q +      PWG+C     NPN + +   
Sbjct: 254 IFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGEC-----NPNIKLQNFS 308

Query: 298 PLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDA 357
                       Y+  GC   C+ +++ ++CGC    +PG    C  Q+Y +C  P +D 
Sbjct: 309 S-----------YSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDH 357

Query: 358 MLRKDSC-------ACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLA 410
           +  KD C       +CP  C    Y   +S    PS+ A ++L++KLN+S  YI EN++ 
Sbjct: 358 IEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVK 417

Query: 411 LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYL 460
           ++I +  LNY+  +Q+KA  +SELL D+GGQ+GLF GASL+TI+EI++YL
Sbjct: 418 IEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYL 467


>gi|227430289 sodium channel, nonvoltage-gated 1 alpha isoform 2
           [Homo sapiens]
          Length = 728

 Score =  143 bits (361), Expect = 4e-34
 Identities = 112/418 (26%), Positives = 185/418 (44%), Gaps = 47/418 (11%)

Query: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214
           +L + +  CRF    C   N++     M G CYTFN   + + L  ++  G+ NGL +ML
Sbjct: 333 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 391

Query: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274
             +Q +++P+           G RV +H Q+EP  +D  G  + PG +T +S +++ L  
Sbjct: 392 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 445

Query: 275 LPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY 334
           L   +GDC+    +         P+ +  PS    YT   C  +C    + ++CGC  ++
Sbjct: 446 LGGDYGDCTKNGSDV--------PVENLYPS---KYTQQVCIHSCFQESMIKECGCAYIF 494

Query: 335 --MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIPS 386
              P +V  C  +++ +  +      +   S        C  PC+ T Y       R PS
Sbjct: 495 YPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPS 554

Query: 387 RAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQM 442
             +  ++ + L+R   Y   N    V  ++IFF+ LNY+T  +  +  M  LL ++G Q 
Sbjct: 555 VTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQW 614

Query: 443 GLFIGASLLTILE----ILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQV 498
            L+ G+S+L+++E    + D L  +F   +L  F +R  S         +       +  
Sbjct: 615 SLWFGSSVLSVVEMAELVFDLLVIMFL-MLLRRFRSRYWSPGRGGRGAQEVASTLASSPP 673

Query: 499 PHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP--------AVCVLGAP 548
            H    P +L  S+   P P PSP L+ PP A ATL     P        + C LG P
Sbjct: 674 SHFCPHPMSLSLSQ---PGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 728



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78
           F +N ++HG   +       ++   WA   + +     +Q       Y  F +  +L+  
Sbjct: 121 FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 178

Query: 79  RESHRLIFPAVTLCNINPLR 98
             S +L+FPAVT+C +NP R
Sbjct: 179 LNSDKLVFPAVTICTLNPYR 198


>gi|227430287 sodium channel, nonvoltage-gated 1 alpha isoform 3
           [Homo sapiens]
          Length = 692

 Score =  143 bits (361), Expect = 4e-34
 Identities = 112/418 (26%), Positives = 185/418 (44%), Gaps = 47/418 (11%)

Query: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214
           +L + +  CRF    C   N++     M G CYTFN   + + L  ++  G+ NGL +ML
Sbjct: 297 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 355

Query: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274
             +Q +++P+           G RV +H Q+EP  +D  G  + PG +T +S +++ L  
Sbjct: 356 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 409

Query: 275 LPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY 334
           L   +GDC+    +         P+ +  PS    YT   C  +C    + ++CGC  ++
Sbjct: 410 LGGDYGDCTKNGSDV--------PVENLYPS---KYTQQVCIHSCFQESMIKECGCAYIF 458

Query: 335 --MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIPS 386
              P +V  C  +++ +  +      +   S        C  PC+ T Y       R PS
Sbjct: 459 YPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPS 518

Query: 387 RAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQM 442
             +  ++ + L+R   Y   N    V  ++IFF+ LNY+T  +  +  M  LL ++G Q 
Sbjct: 519 VTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQW 578

Query: 443 GLFIGASLLTILE----ILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQV 498
            L+ G+S+L+++E    + D L  +F   +L  F +R  S         +       +  
Sbjct: 579 SLWFGSSVLSVVEMAELVFDLLVIMFL-MLLRRFRSRYWSPGRGGRGAQEVASTLASSPP 637

Query: 499 PHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP--------AVCVLGAP 548
            H    P +L  S+   P P PSP L+ PP A ATL     P        + C LG P
Sbjct: 638 SHFCPHPMSLSLSQ---PGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 692



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78
           F +N ++HG   +       ++   WA   + +     +Q       Y  F +  +L+  
Sbjct: 85  FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 142

Query: 79  RESHRLIFPAVTLCNINPLR 98
             S +L+FPAVT+C +NP R
Sbjct: 143 LNSDKLVFPAVTICTLNPYR 162


>gi|4506815 sodium channel, nonvoltage-gated 1 alpha isoform 1 [Homo
           sapiens]
          Length = 669

 Score =  143 bits (361), Expect = 4e-34
 Identities = 112/418 (26%), Positives = 185/418 (44%), Gaps = 47/418 (11%)

Query: 156 SLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIML 214
           +L + +  CRF    C   N++     M G CYTFN   + + L  ++  G+ NGL +ML
Sbjct: 274 TLGNFIFACRFNQVSCNQANYSHFHHPMYGNCYTFND-KNNSNLWMSSMPGINNGLSLML 332

Query: 215 DVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSF 274
             +Q +++P+           G RV +H Q+EP  +D  G  + PG +T +S +++ L  
Sbjct: 333 RAEQNDFIPLLST------VTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETLDR 386

Query: 275 LPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY 334
           L   +GDC+    +         P+ +  PS    YT   C  +C    + ++CGC  ++
Sbjct: 387 LGGDYGDCTKNGSDV--------PVENLYPS---KYTQQVCIHSCFQESMIKECGCAYIF 435

Query: 335 --MPGDVPVCSPQQYKNCAHPAIDAMLRKDS------CACPNPCASTRYAKELSMVRIPS 386
              P +V  C  +++ +  +      +   S        C  PC+ T Y       R PS
Sbjct: 436 YPRPQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPS 495

Query: 387 RAAARFLARKLNRSEAYIAEN----VLALDIFFEALNYETVEQKKAYEMSELLGDIGGQM 442
             +  ++ + L+R   Y   N    V  ++IFF+ LNY+T  +  +  M  LL ++G Q 
Sbjct: 496 VTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFFKELNYKTNSESPSVTMVTLLSNLGSQW 555

Query: 443 GLFIGASLLTILE----ILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQV 498
            L+ G+S+L+++E    + D L  +F   +L  F +R  S         +       +  
Sbjct: 556 SLWFGSSVLSVVEMAELVFDLLVIMFL-MLLRRFRSRYWSPGRGGRGAQEVASTLASSPP 614

Query: 499 PHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP--------AVCVLGAP 548
            H    P +L  S+   P P PSP L+ PP A ATL     P        + C LG P
Sbjct: 615 SHFCPHPMSLSLSQ---PGPAPSPALTAPPPAYATLGPRPSPGGSAGASSSTCPLGGP 669



 Score = 35.4 bits (80), Expect = 0.14
 Identities = 21/80 (26%), Positives = 37/80 (46%), Gaps = 3/80 (3%)

Query: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALD-E 78
           F +N ++HG   +       ++   WA   + +     +Q       Y  F +  +L+  
Sbjct: 62  FCNNTTIHGAIRLVCSQHNRMKTAFWAVLWLCTFGMMYWQFGLLFGEY--FSYPVSLNIN 119

Query: 79  RESHRLIFPAVTLCNINPLR 98
             S +L+FPAVT+C +NP R
Sbjct: 120 LNSDKLVFPAVTICTLNPYR 139


>gi|124301196 sodium channel, nonvoltage-gated 1, beta [Homo
           sapiens]
          Length = 640

 Score =  123 bits (308), Expect = 5e-28
 Identities = 83/321 (25%), Positives = 148/321 (46%), Gaps = 33/321 (10%)

Query: 158 DDMLLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDV 216
           + M+L C F  +PC   NFT+IF    G CY FN G    + L +   G   GL ++LD+
Sbjct: 243 EQMILACLFGAEPCNYRNFTSIFYPHYGNCYIFNWGMT-EKALPSANPGTEFGLKLILDI 301

Query: 217 QQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLP 276
            QE+Y+P            G+R+ +H Q   P I   G+    G +T +     +L  + 
Sbjct: 302 GQEDYVPFLAST------AGVRLMLHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMG 355

Query: 277 PPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCR--MVY 334
            P+  C+        +   SD         +  Y++  C  +C   ++ R C C   +  
Sbjct: 356 EPYSPCTVNGSEVPVQNFYSDY--------NTTYSIQACLRSCFQDHMIRNCNCGHYLYP 407

Query: 335 MPGDVPVCSPQQYKNCAHPAIDAML---RKDSCA--CPNPCASTRYAKELSMVRIPSRAA 389
           +P     C+ + + + AH   D  +   ++++C   C   C  T+Y   +SM   PS A+
Sbjct: 408 LPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIGMCKESCNDTQYKMTISMADWPSEAS 467

Query: 390 ARFLARKLNRSE------AYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMG 443
             ++   L++            + ++ L+I+F+  NY T+E+  A  +  LL ++GGQ G
Sbjct: 468 EDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRTIEESAANNIVWLLSNLGGQFG 527

Query: 444 LFIGASLLTILE----ILDYL 460
            ++G S+L ++E    I+D++
Sbjct: 528 FWMGGSVLCLIEFGEIIIDFV 548



 Score = 33.5 bits (75), Expect = 0.52
 Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%)

Query: 20  FASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDER 79
           +  N + HG   +   G    ++ MW    +L  A   +Q    +R Y  +    +L   
Sbjct: 29  YCDNTNTHGPKRIICEGPK--KKAMWFLLTLLFAALVCWQWGIFIRTYLSWEVSVSLSVG 86

Query: 80  ESHRLIFPAVTLCNINPLRRSRL 102
               + FPAVT+CN +P + S++
Sbjct: 87  FK-TMDFPAVTICNASPFKYSKI 108


>gi|42476333 sodium channel, nonvoltage-gated 1, gamma [Homo
           sapiens]
          Length = 649

 Score =  107 bits (268), Expect = 2e-23
 Identities = 82/328 (25%), Positives = 147/328 (44%), Gaps = 51/328 (15%)

Query: 155 HSLDDMLLDCRFRGQPCGPENFTTIFTRM-GKCYTFNSGADGAELLTTTRGGMGNGLDIM 213
           +S +++L+ C F G  C   NFT     M G CYTFN+  +   +L+T+ GG   GL ++
Sbjct: 251 YSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNN-RENETILSTSMGGSEYGLQVI 309

Query: 214 LDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLS 273
           L + +EEY P    +       G +V IH Q+E P ++ +G  +     T +     +  
Sbjct: 310 LYINEEEYNPFLVSS------TGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLTESF 363

Query: 274 FLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPS---PPYTLMGCRLACETRYVARKCGC 330
            L  P+  C+                GS  P  +     Y+L  C  +C    +  KCGC
Sbjct: 364 KLSEPYSQCTED--------------GSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGC 409

Query: 331 RMVY--MPGDVPVCSPQQYKN---CAHPAIDAMLRKD---SCACPNPCASTRYAKELSMV 382
                 +P     C+ QQ+ N   C +    A ++++      C   C+   +    S+ 
Sbjct: 410 AQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQSVCKEACSFKEWTLTTSLA 469

Query: 383 RIPSRAAARFLA------------RKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYE 430
           + PS  + ++L             +KLN+++      +  L IF++ LN  ++ +  A  
Sbjct: 470 QWPSVVSEKWLLPVLTWDQGRQVNKKLNKTD------LAKLLIFYKDLNQRSIMESPANS 523

Query: 431 MSELLGDIGGQMGLFIGASLLTILEILD 458
           +  LL + GGQ+GL++  S++ ++EI++
Sbjct: 524 IEMLLSNFGGQLGLWMSCSVVCVIEIIE 551



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 31/98 (31%), Positives = 47/98 (47%), Gaps = 5/98 (5%)

Query: 3   PTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAE 62
           P +GP+ A      +R +  N + HG   +       LRR +W    + +VA  L+Q A 
Sbjct: 16  PVTGPQ-APTIKELMRWYCLNTNTHGCRRIVVSRG-RLRRLLWIGFTLTAVALILWQCAL 73

Query: 63  RVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRS 100
            V     F+  +   +    +L FPAVT+CNINP + S
Sbjct: 74  LVF---SFYTVSVSIKVHFRKLDFPAVTICNINPYKYS 108


>gi|34101282 sodium channel, nonvoltage-gated 1, delta isoform 2
           [Homo sapiens]
          Length = 638

 Score =  102 bits (254), Expect = 9e-22
 Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)

Query: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219
           +L C + G  C    F T      G CYT     DG  + T  R G+ +G+ ++L V+Q+
Sbjct: 260 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 313

Query: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279
            +LP+           GIRV +H +   P +      V PG +  +S ++ ++  L  P+
Sbjct: 314 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 367

Query: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337
           G C++       E    + L + S      YT   C ++C  + +   C C      +P 
Sbjct: 368 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 416

Query: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391
               CS  ++    H       D    +  C   CP PC  + +       R PS  +A 
Sbjct: 417 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 476

Query: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446
           +    L       +++   + LA ++I ++ LNY +VE+   Y + +LL  +G    L+ 
Sbjct: 477 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 536

Query: 447 GASLLTILEILDYLCE 462
           GAS+L++LE+L+ L +
Sbjct: 537 GASVLSLLELLELLLD 552


>gi|194353989 sodium channel, nonvoltage-gated 1, delta isoform 1
           [Homo sapiens]
          Length = 704

 Score =  102 bits (254), Expect = 9e-22
 Identities = 80/316 (25%), Positives = 138/316 (43%), Gaps = 37/316 (11%)

Query: 161 LLDCRFRGQPCGPENFTTIF-TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQE 219
           +L C + G  C    F T      G CYT     DG  + T  R G+ +G+ ++L V+Q+
Sbjct: 326 VLSCSYDGLDCQARQFRTFHHPTYGSCYT----VDG--VWTAQRPGITHGVGLVLRVEQQ 379

Query: 220 EYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPW 279
            +LP+           GIRV +H +   P +      V PG +  +S ++ ++  L  P+
Sbjct: 380 PHLPLLSTL------AGIRVMVHGRNHTPFLGHHSFSVRPGTEATISIREDEVHRLGSPY 433

Query: 280 GDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVY--MPG 337
           G C++       E    + L + S      YT   C ++C  + +   C C      +P 
Sbjct: 434 GHCTAGG-----EGVEVELLHNTS------YTRQACLVSCFQQLMVETCSCGYYLHPLPA 482

Query: 338 DVPVCSPQQYKNCAHPAI----DAMLRKDSCA--CPNPCASTRYAKELSMVRIPSRAAAR 391
               CS  ++    H       D    +  C   CP PC  + +       R PS  +A 
Sbjct: 483 GAEYCSSARHPAWGHCFYRLYQDLETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAG 542

Query: 392 FLARKLNRS----EAYIAENVLA-LDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFI 446
           +    L       +++   + LA ++I ++ LNY +VE+   Y + +LL  +G    L+ 
Sbjct: 543 WTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLSAMGSLCSLWF 602

Query: 447 GASLLTILEILDYLCE 462
           GAS+L++LE+L+ L +
Sbjct: 603 GASVLSLLELLELLLD 618


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 36.2 bits (82), Expect = 0.080
 Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 13/90 (14%)

Query: 266  SCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVA 325
            SCQ+Q     PPP  +C   +L+ +  P  S+   SPS  PS P +    R   ++  VA
Sbjct: 1398 SCQKQPQDASPPP-KECDQGTLSASLNPSNSE--SSPSRCPSDPDSTSQPRSG-DSADVA 1453

Query: 326  RKCGCRMVYMPGDVPVCSPQQYKNCAHPAI 355
            R             P  +P+ Y+N  HP I
Sbjct: 1454 RDV---------KQPTATPRSYRNFRHPEI 1474


>gi|55741655 anoctamin 8 [Homo sapiens]
          Length = 1232

 Score = 35.8 bits (81), Expect = 0.10
 Identities = 20/38 (52%), Positives = 22/38 (57%), Gaps = 5/38 (13%)

Query: 276  PPPW-----GDCSSASLNPNYEPEPSDPLGSPSPSPSP 308
            PPP      GD S  SL P   P  SDPL +P+PSPSP
Sbjct: 1181 PPPAPQPLPGDASFYSLPPPPLPPTSDPLETPAPSPSP 1218


>gi|157168329 formin 1 [Homo sapiens]
          Length = 1196

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 26/65 (40%), Positives = 29/65 (44%), Gaps = 4/65 (6%)

Query: 487 LQEGLGS--HRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRPAVCV 544
           L  GLGS      +P +S GP         PPLP PS    PPP  P  L +S  PA   
Sbjct: 658 LPSGLGSLSPAPPMPPVSAGPPLPPPPPPPPPLPPPSSAGPPPPPPPPPLPNS--PAPPN 715

Query: 545 LGAPP 549
            G PP
Sbjct: 716 PGGPP 720


>gi|161019170 mucin 5AC [Homo sapiens]
          Length = 6207

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 19/69 (27%), Positives = 25/69 (36%)

Query: 282  CSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPV 341
            C   S++   +P P D  G P P   P +  +    A         C C     P  +PV
Sbjct: 5774 CDEGSVSVQCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPV 5833

Query: 342  CSPQQYKNC 350
            C P Q   C
Sbjct: 5834 CPPGQESIC 5842


>gi|38201621 eukaryotic translation initiation factor 4 gamma, 1
           isoform 1 [Homo sapiens]
          Length = 1599

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 8/62 (12%)

Query: 491 LGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPT----APATLSHSSRPAVCVLG 546
           L SH  ++      P+ ++ SEDL P    SP L+PPP     +P  ++ +++P   + G
Sbjct: 351 LASHTVEIHE----PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNG 406

Query: 547 AP 548
           AP
Sbjct: 407 AP 408


>gi|38201627 eukaryotic translation initiation factor 4 gamma, 1
           isoform 2 [Homo sapiens]
          Length = 1512

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 8/62 (12%)

Query: 491 LGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPT----APATLSHSSRPAVCVLG 546
           L SH  ++      P+ ++ SEDL P    SP L+PPP     +P  ++ +++P   + G
Sbjct: 264 LASHTVEIHE----PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNG 319

Query: 547 AP 548
           AP
Sbjct: 320 AP 321


>gi|38201625 eukaryotic translation initiation factor 4 gamma, 1
           isoform 3 [Homo sapiens]
          Length = 1435

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 8/62 (12%)

Query: 491 LGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPT----APATLSHSSRPAVCVLG 546
           L SH  ++      P+ ++ SEDL P    SP L+PPP     +P  ++ +++P   + G
Sbjct: 187 LASHTVEIHE----PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNG 242

Query: 547 AP 548
           AP
Sbjct: 243 AP 244


>gi|38201623 eukaryotic translation initiation factor 4 gamma, 1
           isoform 1 [Homo sapiens]
          Length = 1599

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 8/62 (12%)

Query: 491 LGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPT----APATLSHSSRPAVCVLG 546
           L SH  ++      P+ ++ SEDL P    SP L+PPP     +P  ++ +++P   + G
Sbjct: 351 LASHTVEIHE----PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNG 406

Query: 547 AP 548
           AP
Sbjct: 407 AP 408


>gi|38201619 eukaryotic translation initiation factor 4 gamma, 1
           isoform 4 [Homo sapiens]
          Length = 1403

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 20/62 (32%), Positives = 33/62 (53%), Gaps = 8/62 (12%)

Query: 491 LGSHRTQVPHLSLGPSTLLCSEDLPPLPVPSPRLSPPPT----APATLSHSSRPAVCVLG 546
           L SH  ++      P+ ++ SEDL P    SP L+PPP     +P  ++ +++P   + G
Sbjct: 155 LASHTVEIHE----PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNG 210

Query: 547 AP 548
           AP
Sbjct: 211 AP 212


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score = 34.3 bits (77), Expect = 0.30
 Identities = 19/69 (27%), Positives = 25/69 (36%)

Query: 282  CSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPV 341
            C   S++   +P P D  G P P   P +  +    A         C C     P  +PV
Sbjct: 5440 CDEGSVSVQCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPV 5499

Query: 342  CSPQQYKNC 350
            C P Q   C
Sbjct: 5500 CPPGQESIC 5508


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 33.1 bits (74), Expect = 0.68
 Identities = 26/80 (32%), Positives = 29/80 (36%), Gaps = 21/80 (26%)

Query: 491 LGSHRTQVPHLSL---GPSTLL-----------------CSEDLPPLPV-PSPRLSPPPT 529
           L SH    P +SL   GP+ LL                      PP P  PSP  +P P 
Sbjct: 205 LNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPA 264

Query: 530 APATLSHSSRPAVCVLGAPP 549
           APA       PA   L  PP
Sbjct: 265 APAAAPPPPPPAPATLARPP 284


>gi|120952764 mastermind-like domain containing 1 [Homo sapiens]
          Length = 774

 Score = 32.7 bits (73), Expect = 0.88
 Identities = 15/44 (34%), Positives = 20/44 (45%), Gaps = 1/44 (2%)

Query: 277 PPWGDCSSASLNPNYEPEPS-DPLGSPSPSPSPPYTLMGCRLAC 319
           P W       L+P Y P PS  P   P P P PP++     ++C
Sbjct: 326 PSWSGLPPPGLSPPYRPVPSPHPPPLPLPPPPPPFSPQSLMVSC 369


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 32.7 bits (73), Expect = 0.88
 Identities = 16/36 (44%), Positives = 18/36 (50%)

Query: 505 PSTLLCSEDLPPLPVPSPRLSPPPTAPATLSHSSRP 540
           P + L     PP PVP+P   PPPTA  T   S  P
Sbjct: 921 PESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSP 956



 Score = 30.4 bits (67), Expect = 4.4
 Identities = 23/76 (30%), Positives = 30/76 (39%), Gaps = 7/76 (9%)

Query: 473 WNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPSTLL---CSEDLPPLPVPSPR----LS 525
           W R      SS   ++     + + VP LS  P  +     S+  PPLP P P       
Sbjct: 581 WKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIVTPYTASQPSPPLPPPPPPPPPPPP 640

Query: 526 PPPTAPATLSHSSRPA 541
           PPP  P  L   S P+
Sbjct: 641 PPPPPPPPLPSQSAPS 656


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,857,244
Number of Sequences: 37866
Number of extensions: 1488361
Number of successful extensions: 10607
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 105
Number of HSP's that attempted gapping in prelim test: 9828
Number of HSP's gapped (non-prelim): 826
length of query: 549
length of database: 18,247,518
effective HSP length: 107
effective length of query: 442
effective length of database: 14,195,856
effective search space: 6274568352
effective search space used: 6274568352
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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