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Search of human proteins with 95147333
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|95147333 phospholipase C, beta 2 [Homo sapiens]
(1185 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 2371 0.0
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 1075 0.0
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 1061 0.0
gi|11386139 phospholipase C beta 3 [Homo sapiens] 1006 0.0
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 689 0.0
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 689 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 338 2e-92
gi|19115964 phospholipase C delta 3 [Homo sapiens] 333 6e-91
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 322 1e-87
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 322 1e-87
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 305 2e-82
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 305 2e-82
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 297 5e-80
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 284 3e-76
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 279 1e-74
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 279 1e-74
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 177 4e-44
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 169 1e-41
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 169 1e-41
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 169 1e-41
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 155 3e-37
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 155 3e-37
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 150 5e-36
gi|148746195 trichohyalin [Homo sapiens] 62 2e-09
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 62 4e-09
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 57 8e-08
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 57 1e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 57 1e-07
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 56 2e-07
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 56 2e-07
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 2371 bits (6144), Expect = 0.0
Identities = 1185/1185 (100%), Positives = 1185/1185 (100%)
Query: 1 MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD 60
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD
Sbjct: 1 MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLD 60
Query: 61 ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE 120
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
Sbjct: 61 ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE 120
Query: 121 NVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR 180
NVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
Sbjct: 121 NVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR 180
Query: 181 VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH 240
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
Sbjct: 181 VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH 240
Query: 241 LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN 300
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN
Sbjct: 241 LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPEN 300
Query: 301 SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC 360
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
Sbjct: 301 SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC 360
Query: 361 WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM 420
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
Sbjct: 361 WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM 420
Query: 421 AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE 480
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE
Sbjct: 421 AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGE 480
Query: 481 AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV 540
AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
Sbjct: 481 AEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV 540
Query: 541 TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM 600
TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
Sbjct: 541 TAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM 600
Query: 601 SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF 660
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
Sbjct: 601 SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF 660
Query: 661 MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT 720
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
Sbjct: 661 MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT 720
Query: 721 KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL 780
KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
Sbjct: 721 KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL 780
Query: 781 CLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGL 840
CLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGL
Sbjct: 781 CLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGL 840
Query: 841 PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK 900
PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK
Sbjct: 841 PEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVK 900
Query: 901 LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP 960
LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP
Sbjct: 901 LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLP 960
Query: 961 REESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL 1020
REESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL
Sbjct: 961 REESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMEL 1020
Query: 1021 AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI 1080
AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI
Sbjct: 1021 AREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI 1080
Query: 1081 QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
Sbjct: 1081 QEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
Query: 1141 SVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL 1185
SVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
Sbjct: 1141 SVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL 1185
>gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform
a [Homo sapiens]
Length = 1216
Score = 1075 bits (2781), Expect = 0.0
Identities = 562/1177 (47%), Positives = 779/1177 (66%), Gaps = 56/1177 (4%)
Query: 8 LLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67
L P V L +G +F+KWDD++T+ +P+ILR DP+G++ YWT Q+KE E LD++ ++D
Sbjct: 13 LKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDA 72
Query: 68 RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWA 127
R G+ AK PK KLR++ ++ + +TVV GPD+V+++ N V+++E V K W
Sbjct: 73 RCGRHAKAPKDPKLRELLDVG-NIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWT 131
Query: 128 EDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSA 187
+V +L + L N SR FL+K KLK+Q+ EG+IP+KN +++F ADRKRVE AL A
Sbjct: 132 NEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEA 191
Query: 188 CHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ 247
C LP +ND+I EDF VY+ FL +LCPRPEID IF+ + AK+KPY+T + + FIN
Sbjct: 192 CSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINL 251
Query: 248 KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDK 307
KQRD RLN +L+PP + +QVQ LI+KYEP+ A++GQ+S +G + +L G EN V++ +K
Sbjct: 252 KQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEK 311
Query: 308 LLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPD 367
L L+ DM+QPL+HYFINSSHNTYLTAGQ +G SS EMYRQVLLSGCRCVELDCWKG+ +
Sbjct: 312 LDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAE 371
Query: 368 EEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI 427
EEP+ITHGFTMTT+I FKE IEAIAE AFKTSP+PI+LSFENHVDSP+QQAKMAEYCR I
Sbjct: 372 EEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLI 431
Query: 428 FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK-----NQFSGPTSSSKDTGGEAE 482
FGD LL EPLEK+PL+ GVPLPSP DL KIL+KNKK ++ SG S+
Sbjct: 432 FGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYS 491
Query: 483 GSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA 542
SS P+ G AGE TE ++++ D+++ KK DEGTAG E A
Sbjct: 492 DSSSMFEPSSPG---AGEADTESDDDD------------DDDDCKKSSMDEGTAGSEAMA 536
Query: 543 YEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR 602
EEMS+LVNYIQP KF SFE S ++N+S+ +SSF E K + L+K+ V+FV+YNK Q+SR
Sbjct: 537 TEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSR 596
Query: 603 IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR 662
IYPKGTR+DSSNYMPQ+FWNAGCQMVALNFQTMDL MQ NM ++E+NG+SGY LK EFMR
Sbjct: 597 IYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMR 656
Query: 663 RPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRR-YRTK 721
RPDK F+PF+ +D +VA TLS+ +ISGQFLS++ V TYVEV++FGLP D +R+ ++TK
Sbjct: 657 RPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTK 716
Query: 722 LSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLC 781
S N++NPVW+EEP VF+K+++P LA LR+AV EEG KF+GHRI+P+ A+ GYH++C
Sbjct: 717 TSQG-NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYIC 775
Query: 782 LHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKL-------- 833
L +E N PLT+PA+F+++E+KDY+P +AD+ AL+NPI++ + + ++ +L
Sbjct: 776 LRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDE 835
Query: 834 ----KEAMGGLPEKPFPLASPVASQVNG-----ALAP----------TSNGSPAARAGAR 874
KEA G P + NG L P + GS A A
Sbjct: 836 EEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE 895
Query: 875 EEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAEL 934
+ E ++EEL++ K VKLQ++H KE+++L +R ++ +L++ + E+
Sbjct: 896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEI 955
Query: 935 GPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDG----RVRELKDRLELE 990
+ A + K S+KK + + + +D ++ +LKD+ + +
Sbjct: 956 QNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQ 1015
Query: 991 LLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETK 1050
LL +EQY +K +H+ I K+ ++A E Q +LK LKE E + KE+KKK++ K
Sbjct: 1016 LLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKK 1075
Query: 1051 RLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLE 1110
R E+I + DK E K E+ S+IQEVVQ IK++ E + QEKL EK +
Sbjct: 1076 RQEKI--TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
Query: 1111 QIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLR 1147
QI + + + Q E EY+ + K L E+ E V+ ++
Sbjct: 1134 QILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMK 1170
>gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform
b [Homo sapiens]
Length = 1173
Score = 1061 bits (2743), Expect = 0.0
Identities = 553/1142 (48%), Positives = 761/1142 (66%), Gaps = 56/1142 (4%)
Query: 8 LLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67
L P V L +G +F+KWDD++T+ +P+ILR DP+G++ YWT Q+KE E LD++ ++D
Sbjct: 13 LKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDA 72
Query: 68 RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWA 127
R G+ AK PK KLR++ ++ + +TVV GPD+V+++ N V+++E V K W
Sbjct: 73 RCGRHAKAPKDPKLRELLDVG-NIGRLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWT 131
Query: 128 EDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSA 187
+V +L + L N SR FL+K KLK+Q+ EG+IP+KN +++F ADRKRVE AL A
Sbjct: 132 NEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEA 191
Query: 188 CHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ 247
C LP +ND+I EDF VY+ FL +LCPRPEID IF+ + AK+KPY+T + + FIN
Sbjct: 192 CSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINL 251
Query: 248 KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDK 307
KQRD RLN +L+PP + +QVQ LI+KYEP+ A++GQ+S +G + +L G EN V++ +K
Sbjct: 252 KQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEK 311
Query: 308 LLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPD 367
L L+ DM+QPL+HYFINSSHNTYLTAGQ +G SS EMYRQVLLSGCRCVELDCWKG+ +
Sbjct: 312 LDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAE 371
Query: 368 EEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI 427
EEP+ITHGFTMTT+I FKE IEAIAE AFKTSP+PI+LSFENHVDSP+QQAKMAEYCR I
Sbjct: 372 EEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLI 431
Query: 428 FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK-----NQFSGPTSSSKDTGGEAE 482
FGD LL EPLEK+PL+ GVPLPSP DL KIL+KNKK ++ SG S+
Sbjct: 432 FGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYS 491
Query: 483 GSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTA 542
SS P+ G AGE TE ++++ D+++ KK DEGTAG E A
Sbjct: 492 DSSSMFEPSSPG---AGEADTESDDDD------------DDDDCKKSSMDEGTAGSEAMA 536
Query: 543 YEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR 602
EEMS+LVNYIQP KF SFE S ++N+S+ +SSF E K + L+K+ V+FV+YNK Q+SR
Sbjct: 537 TEEMSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSR 596
Query: 603 IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR 662
IYPKGTR+DSSNYMPQ+FWNAGCQMVALNFQTMDL MQ NM ++E+NG+SGY LK EFMR
Sbjct: 597 IYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMR 656
Query: 663 RPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRR-YRTK 721
RPDK F+PF+ +D +VA TLS+ +ISGQFLS++ V TYVEV++FGLP D +R+ ++TK
Sbjct: 657 RPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTK 716
Query: 722 LSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLC 781
S N++NPVW+EEP VF+K+++P LA LR+AV EEG KF+GHRI+P+ A+ GYH++C
Sbjct: 717 TSQG-NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYIC 775
Query: 782 LHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKL-------- 833
L +E N PLT+PA+F+++E+KDY+P +AD+ AL+NPI++ + + ++ +L
Sbjct: 776 LRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDE 835
Query: 834 ----KEAMGGLPEKPFPLASPVASQVNG-----ALAP----------TSNGSPAARAGAR 874
KEA G P + NG L P + GS A A
Sbjct: 836 EEVKKEADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTE 895
Query: 875 EEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAEL 934
+ E ++EEL++ K VKLQ++H KE+++L +R ++ +L++ + E+
Sbjct: 896 DLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEI 955
Query: 935 GPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDG----RVRELKDRLELE 990
+ A + K S+KK + + + +D ++ +LKD+ + +
Sbjct: 956 QNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQ 1015
Query: 991 LLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETK 1050
LL +EQY +K +H+ I K+ ++A E Q +LK LKE E + KE+KKK++ K
Sbjct: 1016 LLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKK 1075
Query: 1051 RLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLE 1110
R E+I + DK E K E+ S+IQEVVQ IK++ E + QEKL EK +
Sbjct: 1076 RQEKI--TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQ 1133
Query: 1111 QI 1112
QI
Sbjct: 1134 QI 1135
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 1006 bits (2602), Expect = 0.0
Identities = 563/1227 (45%), Positives = 762/1227 (62%), Gaps = 104/1227 (8%)
Query: 8 LLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDT 67
L PP V L +G +FIKWD+ET+ + V LRVDP G++LYWT + E++ LDI+SIRDT
Sbjct: 13 LEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDT 72
Query: 68 RFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWA 127
R G++A++PK K+R+V PD K +TVVSGPD V+ F NF++ +++ K W+
Sbjct: 73 RTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQDDTAKVWS 132
Query: 128 EDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSA 187
E++ L + L NASR+TFL K KLK+Q+N +G+IPVKN +MF AD+KRVE AL +
Sbjct: 133 EELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALES 192
Query: 188 CHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQ 247
C L ++++I P++F +++ FL LC RP+ID+I AK KPY+T E L FINQ
Sbjct: 193 CGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQ 252
Query: 248 KQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDK 307
KQRD RLN +L+PP RP Q + LI+KYEP+ +R Q+S EG +L G EN +L +
Sbjct: 253 KQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEA 312
Query: 308 LLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPD 367
L L DMTQPL+ YFINSSHNTYLTAGQ +G SS EMYRQ LL GCRCVELD WKG+PP+
Sbjct: 313 LDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPE 372
Query: 368 EEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTI 427
EEP ITHGFTMTT++ ++ +EAIAE+AFKTSPYP+ILSFENHVDS +QQAKMAEYCR+I
Sbjct: 373 EEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSI 432
Query: 428 FGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKN---QFSGPTSSSK--------- 475
FGD LL EPL+K+PL PGVPLPSP+DL G+IL+KNKK GP S+ +
Sbjct: 433 FGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNS 492
Query: 476 ---DTGGEAEGSSP----PSA----------------PAGEGTVWAGEEG---------- 502
++ E SSP PS+ P+ E G+EG
Sbjct: 493 ALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGP 552
Query: 503 TELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFE 562
+ E+EE +EEEEE++ + KK +DEGTA EV A EEMS+LVNYI+P KF SFE
Sbjct: 553 ADREDEEEDEEEEEQT------DPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFE 606
Query: 563 FSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWN 622
+ ++N+ + +SSF E KA + L+K+ ++FV+YNK+Q+SRIYPKGTR+DSSNYMPQ+FWN
Sbjct: 607 AARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWN 666
Query: 623 AGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVAT 682
GCQ+VALNFQT+D+ MQ N VFE+NG+SGYLLK EFMRRPDK F+PF+ +D +VA
Sbjct: 667 VGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVAN 726
Query: 683 TLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742
L + VISGQFLS+R V YVEV++FGLP D +R+YRT+ S NS NPVW EEPF F K
Sbjct: 727 ALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQG-NSFNPVWDEEPFDFPK 785
Query: 743 ILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMK 802
+++P LASLR+A EEG KF+GHRI+P++A+ SGYH++CL +E+N PL +PAL I+ E
Sbjct: 786 VVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEAS 845
Query: 803 DYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMG-------------------GLPEK 843
DYIP D AL NPIK S D ++ +L +G G
Sbjct: 846 DYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQPS 905
Query: 844 PFPLASPVASQVNGALAPTSNGSPAARA----GAREEAMKE-AAEPRTASLEELRELKGV 898
P SP+ + PT+ SPA+ + G R++ + +E L+ELR K +
Sbjct: 906 SNPTPSPLDASPRRPPGPTT--SPASTSLSSPGQRDDLIASILSEVAPTPLDELRGHKAL 963
Query: 899 VKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRS 958
VKL+ R E++LREL ++ R+ L +R LA+ G C+L PG
Sbjct: 964 VKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQ-----AQAEGRCRLRPG-------- 1010
Query: 959 LPREESAGAAPGEG-PEGVD--GRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQIS 1015
GAA E EG D R +E ++R LL E Q + +R+ +H+ + +
Sbjct: 1011 ----ALGGAADVEDTKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQ 1066
Query: 1016 KMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREI 1075
++ E+ + + K LKE +E + KE++K L+ KR I DK +E EI
Sbjct: 1067 RLREVVLDANTTQFKRLKEMNEREKKELQKILDRKRHNSIS--EAKMRDKHKKEAELTEI 1124
Query: 1076 NNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLE 1135
N HI E V I+++ E ++ ++L Q L+Q+ E E + LA+ +
Sbjct: 1125 NRRHITESVNSIRRLEEAQKQRHDRLVAGQQQVLQQLAEEEPKL----LAQLAQECQEQR 1180
Query: 1136 AEVKESVRACLRTCFPSEAKDKPERAC 1162
A + + +R L P D P AC
Sbjct: 1181 ARLPQEIRRSLLGEMPEGLGDGPLVAC 1207
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 689 bits (1779), Expect = 0.0
Identities = 413/1175 (35%), Positives = 648/1175 (55%), Gaps = 63/1175 (5%)
Query: 12 KVKAYLSQGERFIKWDDETTVASP-VILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFG 70
+V ++L +G F ++++E+ V P + +VD G++L W + KE + L+ + I R G
Sbjct: 12 EVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSG 71
Query: 71 KFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDV 130
K PK + +N + + V SG D+V+++F V+ V K W E +
Sbjct: 72 AIPKDPKILAALEAVGKS--ENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGL 129
Query: 131 LALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADR--KRVEAALSAC 188
+++ + N S T L K +KL N+ GKIPV++ + F + + K + AL
Sbjct: 130 RSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKEL 189
Query: 189 HLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQK 248
LP GKND I P F + +CPR +I+++F + Y+T + L F+N+
Sbjct: 190 GLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEH 249
Query: 249 QRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKL 308
QRD RLN +LFP + +I+ YEP ++G +S +G +L EN+ + D+L
Sbjct: 250 QRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRL 309
Query: 309 LLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDE 368
L+ +M PL HYFI+SSHNTYLT QF G SS EMYRQVLL+GCRCVELDCW GK D+
Sbjct: 310 ELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQ 369
Query: 369 EPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIF 428
EPIITHG M TDI FK+ I+AI E+AF TS YP+ILSFENH S QQ KM++YC +F
Sbjct: 370 EPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCEDLF 428
Query: 429 GDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNK-------KNQF--------SGPTSS 473
GD+LL + LE PL+PG LPSP DL+ KILIKNK K Q +G ++S
Sbjct: 429 GDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESAS 488
Query: 474 SKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEE----EEESGNLDEEEIKKM 529
+ + SA E + G EL +++ +E + G + E+ +
Sbjct: 489 PANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAW 548
Query: 530 QSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKAS 589
+ G + +S+++NY QP KF F + ++N Y +SSF E L +
Sbjct: 549 MASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHA 608
Query: 590 VQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFN 649
++FV+YNKRQMSRIYPKG R+DSSNYMPQ+FWNAGCQMV+LN+QT DL MQ N FE+N
Sbjct: 609 IEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYN 668
Query: 650 GQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFG 709
G GYLLK +FMRRPD+ F+PFS +D V+A T S+ VISGQFLS++ + TYVEV+++G
Sbjct: 669 GSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYG 728
Query: 710 LPGDP-KRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRII 768
LP D ++ +RT++ N +NPV+ EE FVF K+++P+LA LR+AV ++ NK +G RI+
Sbjct: 729 LPTDTIRKEFRTRM-VMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRIL 787
Query: 769 PINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDT 828
P++ L +GY H+ L +E N PL++P +F + +K Y+P + D+ AL++P KF S +
Sbjct: 788 PLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEK 847
Query: 829 KSVKLKEAMG-------GLPE---------KPFPLASPVASQVNGALAPTSNGSPAARAG 872
++ +++ AMG +P K + V Q + L PT+ + A+
Sbjct: 848 RADQMR-AMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGV- 905
Query: 873 AREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLA 932
EA K +E+L+++K +K ++ +KEL L+++ A+ + + Q+
Sbjct: 906 ---EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVD 962
Query: 933 ELGPPGVGGVGACKLGPGKGSRKK---RSLPREESAGAAPGEGPEGVDGRVREL-----K 984
++ + K +KK L ++ +V+E+ K
Sbjct: 963 KIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTK 1022
Query: 985 DRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMK 1044
+ E+ EEQ + ++ H+++Q + +L + + LK + + ++KEM+
Sbjct: 1023 EWSEMINTHSAEEQ-----EIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMR 1077
Query: 1045 KKLETKRLERIQGMT--KVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLE 1102
+E + ++ K +K +ER RE+N+S+ ++ ++ K++ + ++L+
Sbjct: 1078 AHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLK 1137
Query: 1103 EKQAACLEQIREMEKQFQKEALAEYEARMKGLEAE 1137
+ Q LE + + +Q K A + + +G A+
Sbjct: 1138 KVQLEHLEFLEKQNEQLLKSCHAVSQTQGEGDAAD 1172
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 689 bits (1779), Expect = 0.0
Identities = 417/1176 (35%), Positives = 652/1176 (55%), Gaps = 69/1176 (5%)
Query: 12 KVKAYLSQGERFIKWDDETTVASP-VILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFG 70
+V ++L +G F ++++E+ V P + +VD G++L W + KE + L+ + I R G
Sbjct: 12 EVPSFLQEGTVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSG 71
Query: 71 KFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDV 130
K PK + +N + + V SG D+V+++F V+ V K W E +
Sbjct: 72 AIPKDPKILAALEAVGKS--ENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGL 129
Query: 131 LALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADR--KRVEAALSAC 188
+++ + N S T L K +KL N+ GKIPV++ + F + + K + AL
Sbjct: 130 RSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKEL 189
Query: 189 HLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQK 248
LP GKND I P F + +CPR +I+++F + Y+T + L F+N+
Sbjct: 190 GLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEH 249
Query: 249 QRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKL 308
QRD RLN +LFP + +I+ YEP ++G +S +G +L EN+ + D+L
Sbjct: 250 QRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRL 309
Query: 309 LLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDE 368
L+ +M PL HYFI+SSHNTYLT QF G SS EMYRQVLL+GCRCVELDCW GK D+
Sbjct: 310 ELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQ 369
Query: 369 EPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIF 428
EPIITHG M TDI FK+ I+AI E+AF TS YP+ILSFENH S QQ KM++YC +F
Sbjct: 370 EPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHC-SKYQQYKMSKYCEDLF 428
Query: 429 GDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNK-------KNQF--------SGPTSS 473
GD+LL + LE PL+PG LPSP DL+ KILIKNK K Q +G ++S
Sbjct: 429 GDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEALRSMMEAGESAS 488
Query: 474 SKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEE----EEESGNLDEEEIKKM 529
+ + SA E + G EL +++ +E + G + E+ +
Sbjct: 489 PANILEDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKKGLVTVEDEQAW 548
Query: 530 QSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKAS 589
+ G + +S+++NY QP KF F + ++N Y +SSF E L +
Sbjct: 549 MASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHA 608
Query: 590 VQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFN 649
++FV+YNKRQMSRIYPKG R+DSSNYMPQ+FWNAGCQMV+LN+QT DL MQ N FE+N
Sbjct: 609 IEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYN 668
Query: 650 GQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFG 709
G GYLLK +FMRRPD+ F+PFS +D V+A T S+ VISGQFLS++ + TYVEV+++G
Sbjct: 669 GSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYG 728
Query: 710 LPGDP-KRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRII 768
LP D ++ +RT++ N +NPV+ EE FVF K+++P+LA LR+AV ++ NK +G RI+
Sbjct: 729 LPTDTIRKEFRTRM-VMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNKLIGQRIL 787
Query: 769 PINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDT 828
P++ L +GY H+ L +E N PL++P +F + +K Y+P + D+ AL++P KF S +
Sbjct: 788 PLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEK 847
Query: 829 KSVKLKEAMG-------GLPE---------KPFPLASPVASQVNGALAPTSNGSPAARAG 872
++ +++ AMG +P K + V Q + L PT+ + A+
Sbjct: 848 RADQMR-AMGIETSDIADVPSDTSKNDKKGKANTAKANVTPQSSSELRPTTTAALASGV- 905
Query: 873 AREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLA 932
EA K +E+L+++K +K ++ +KEL L+++ A+ + + Q+
Sbjct: 906 ---EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVD 962
Query: 933 ELGPPGVGGVGACKLGPGKGSRKK---RSLPREESAGAAPGEGPEGVDGRVREL-----K 984
++ + K +KK L ++ +V+E+ K
Sbjct: 963 KIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTK 1022
Query: 985 DRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMK 1044
+ E+ EEQ + ++ H+++Q + +L + + LK + + ++KEM+
Sbjct: 1023 EWSEMINTHSAEEQ-----EIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMR 1077
Query: 1045 KKLETKRLERIQGMT--KVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLE 1102
+E + ++ K +K +ER RE+N+S+ ++ ++ K++ + ++L+
Sbjct: 1078 AHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLK 1137
Query: 1103 EKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEV 1138
+ Q LE + +EKQ ++ A+ +M LEAE+
Sbjct: 1138 KVQ---LEHLEFLEKQNEQ---AKEMQQMVKLEAEM 1167
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 338 bits (866), Expect = 2e-92
Identities = 227/617 (36%), Positives = 318/617 (51%), Gaps = 69/617 (11%)
Query: 208 YKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQV 267
+ F +L R E+ E+F S+ A + E L F+ ++Q++ S L
Sbjct: 195 FVQFYKALTKRAEVQELFESFSADGQKLTLLEFLD-FLQEEQKERDCTSEL--------A 245
Query: 268 QGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSH 327
LID+YEPS R LS +G + +LC + + L ++ DMTQPLNHYFI SSH
Sbjct: 246 LELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSH 305
Query: 328 NTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEA 387
NTYL Q G SS E Y + L GCRCVE+D W G P EP++ HG T+T+ I FK+
Sbjct: 306 NTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDG--PSGEPVVYHGHTLTSRILFKDV 363
Query: 388 IEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVP 447
+ +A+ AF+TS YP+ILS E H S QQ MA + I G+ LL+ L+ + P
Sbjct: 364 VATVAQYAFQTSDYPVILSLETHC-SWEQQQTMARHLTEILGEQLLSTTLD--GVLP-TQ 419
Query: 448 LPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEE 507
LPSPE+LR KIL+K KK + +D E E + P EE E
Sbjct: 420 LPSPEELRRKILVKGKK------LTLEEDLEYEEEEAEPEL-----------EESELALE 462
Query: 508 EEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQK 567
+ E E E + NL ++ KK + +SSLV Y++ F SF S +
Sbjct: 463 SQFETEPEPQEQNLQNKDKKKKS--------KPILCPALSSLVIYLKSVSFRSFTHSKEH 514
Query: 568 NRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQM 627
Y ISSF+E KA L+ +A +FV +N Q+SR+YP G R DSSNY PQ WNAGCQM
Sbjct: 515 YHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQM 574
Query: 628 VALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR------RPDKQFNPFSVDRIDVVVA 681
VA+N QT L M F NG GY+LK +F+R P+K +PF A
Sbjct: 575 VAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFK--------A 626
Query: 682 TTLSITVISGQFLSE-------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWK 734
TL I VISGQ L + V V+V++FG+ D R+ + N NP W
Sbjct: 627 QTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYV--ENNGFNPYWG 684
Query: 735 EEPFVFEKILMPELASLRVAVME----EGNKFLGHRIIPINALNSGYHHLCLHSESNMPL 790
+ + ++L+PELA LR VM+ N F+G +P + GY H+ L S+ + L
Sbjct: 685 QT--LCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISL 742
Query: 791 TMPALFIFLEMKDYIPG 807
++F+++ +++ + G
Sbjct: 743 RPASIFVYICIQEGLEG 759
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 333 bits (854), Expect = 6e-91
Identities = 224/647 (34%), Positives = 322/647 (49%), Gaps = 77/647 (11%)
Query: 167 VKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFT 226
+K+ +M D + A L ND + + E FL L RPE++EIF
Sbjct: 207 IKSLLRMVNVDMNDMYAYLLFKECDHSNNDRLEGAEIEE-----FLRRLLKRPELEEIFH 261
Query: 227 SYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQL 286
Y + + E L +Q + + L + Q LI YE + Q +
Sbjct: 262 QYSGEDRVLSAPELLEFLEDQGEEGATLA----------RAQQLIQTYELNETAKQHELM 311
Query: 287 SPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYR 346
+ +G + +L PE + L + DM QPL HYFI+SSHNTYLT Q G SS E Y
Sbjct: 312 TLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLTDSQIGGPSSTEAYV 371
Query: 347 QVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILS 406
+ GCRCVELDCW+G P EP+I HG T+T+ I F++ ++A+ + AF SPYP+ILS
Sbjct: 372 RAFAQGCRCVELDCWEG--PGGEPVIYHGHTLTSKILFRDVVQAVRDHAFTLSPYPVILS 429
Query: 407 FENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQ 466
ENH QQA MA + TI GDML+T+ L+ LPSPE L+G++L+K KK
Sbjct: 430 LENHCGL-EQQAAMARHLCTILGDMLVTQALDS---PNPEELPSPEQLKGRVLVKGKKL- 484
Query: 467 FSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEI 526
P+A + +G + E EEEE +EEEEEE + +
Sbjct: 485 --------------------PAARSEDGRALSDRE----EEEEDDEEEEEEVEAAAQRRL 520
Query: 527 KKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLS 586
K S E +S+L Y T+ + + + +SS +E KA L+
Sbjct: 521 AKQISPE------------LSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIR 568
Query: 587 KASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVF 646
+A FV +N RQ++R+YP G RM+S+NY PQ WN+GCQ+VALNFQT M N F
Sbjct: 569 EAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRF 628
Query: 647 EFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERS-------V 699
NGQ GY+LK +R+PD F+P TTLSI V++ Q L + + V
Sbjct: 629 LVNGQCGYVLKPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIV 684
Query: 700 RTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVME-- 757
V +E+ G+P D R+ + N NP W + + ++ PELA +R V +
Sbjct: 685 DPLVRIEIHGVPADCARQETDYV--LNNGFNPRWGQT--LQFQLRAPELALVRFVVEDYD 740
Query: 758 --EGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMK 802
N F+G +P+++L GY H+ L S+ L+ LFI + ++
Sbjct: 741 ATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 322 bits (825), Expect = 1e-87
Identities = 219/610 (35%), Positives = 312/610 (51%), Gaps = 70/610 (11%)
Query: 209 KSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQ 268
++F L R EID F + ++ + L F+ +QR+ A P
Sbjct: 202 EAFYKMLTQRVEIDRTFAEAAGSGET-LSVDQLVTFLQHQQREEA--------AGPALAL 252
Query: 269 GLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHN 328
LI++YEPS + Q++ +G + +L + S + ++ DM QPL+HY ++SSHN
Sbjct: 253 SLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHN 312
Query: 329 TYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAI 388
TYL Q +G SS E Y + L GCRC+ELDCW G P++EPII HG+T T+ I F + +
Sbjct: 313 TYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPIIYHGYTFTSKILFCDVL 370
Query: 389 EAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVP- 447
AI + AFK SPYP+ILS ENH + QQ MA + I G MLL PL+ GV
Sbjct: 371 RAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPMLLNRPLD------GVTN 423
Query: 448 -LPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAG-EGTVWAGE-EGTE 504
LPSPE L+GKIL+K KK G PP G E TV + E E E
Sbjct: 424 SLPSPEQLKGKILLKGKK----------------LGGLLPPGGEGGPEATVVSDEDEAAE 467
Query: 505 LEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFS 564
+E+E V + + E++++ Q E+S +V Y + F F
Sbjct: 468 MEDEAVRSRVQHKP---KEDKLRLAQ--------------ELSDMVIYCKSVHFGGFSSP 510
Query: 565 AQKNRS-YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNA 623
++ Y ++SF+E +A LL ++ FV +N +SRIYP G R DSSNY P WN
Sbjct: 511 GTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNG 570
Query: 624 GCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATT 683
GCQ+VALNFQT M F+ NG GY+LK F+R P+ FNP ++ +
Sbjct: 571 GCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKR 630
Query: 684 LSITVISGQFLSERS------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEP 737
L+I VISGQ L + + V V VE+ G+ D R + + N NP W E
Sbjct: 631 LNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVI--TNNGFNPWWDTE- 687
Query: 738 FVFEKILMPELASLRVAVME----EGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMP 793
F FE +++P+LA +R V + N F+G IP+N+L GY H+ L S++
Sbjct: 688 FAFE-VVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSA 746
Query: 794 ALFIFLEMKD 803
LF+ + ++D
Sbjct: 747 TLFVKISLQD 756
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 322 bits (825), Expect = 1e-87
Identities = 219/610 (35%), Positives = 312/610 (51%), Gaps = 70/610 (11%)
Query: 209 KSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQ 268
++F L R EID F + ++ + L F+ +QR+ A P
Sbjct: 223 EAFYKMLTQRVEIDRTFAEAAGSGET-LSVDQLVTFLQHQQREEA--------AGPALAL 273
Query: 269 GLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHN 328
LI++YEPS + Q++ +G + +L + S + ++ DM QPL+HY ++SSHN
Sbjct: 274 SLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHN 333
Query: 329 TYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAI 388
TYL Q +G SS E Y + L GCRC+ELDCW G P++EPII HG+T T+ I F + +
Sbjct: 334 TYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPIIYHGYTFTSKILFCDVL 391
Query: 389 EAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVP- 447
AI + AFK SPYP+ILS ENH + QQ MA + I G MLL PL+ GV
Sbjct: 392 RAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPMLLNRPLD------GVTN 444
Query: 448 -LPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAG-EGTVWAGE-EGTE 504
LPSPE L+GKIL+K KK G PP G E TV + E E E
Sbjct: 445 SLPSPEQLKGKILLKGKK----------------LGGLLPPGGEGGPEATVVSDEDEAAE 488
Query: 505 LEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFS 564
+E+E V + + E++++ Q E+S +V Y + F F
Sbjct: 489 MEDEAVRSRVQHKP---KEDKLRLAQ--------------ELSDMVIYCKSVHFGGFSSP 531
Query: 565 AQKNRS-YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNA 623
++ Y ++SF+E +A LL ++ FV +N +SRIYP G R DSSNY P WN
Sbjct: 532 GTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNG 591
Query: 624 GCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATT 683
GCQ+VALNFQT M F+ NG GY+LK F+R P+ FNP ++ +
Sbjct: 592 GCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKR 651
Query: 684 LSITVISGQFLSERS------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEP 737
L+I VISGQ L + + V V VE+ G+ D R + + N NP W E
Sbjct: 652 LNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVI--TNNGFNPWWDTE- 708
Query: 738 FVFEKILMPELASLRVAVME----EGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMP 793
F FE +++P+LA +R V + N F+G IP+N+L GY H+ L S++
Sbjct: 709 FAFE-VVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSA 767
Query: 794 ALFIFLEMKD 803
LF+ + ++D
Sbjct: 768 TLFVKISLQD 777
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 305 bits (780), Expect = 2e-82
Identities = 246/778 (31%), Positives = 374/778 (48%), Gaps = 100/778 (12%)
Query: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104
L W K+ E +DI SI++ R GK + +S + D + D +V+ G
Sbjct: 172 LRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDC--------AFSVIYG 223
Query: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPLTANAS-----RSTFLDKILVKLK 156
+ L + V+ +V W + L+ KH L S R++++ ++ ++
Sbjct: 224 ENYESL---DLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI- 279
Query: 157 MQLNSEGKIPVKNFFQMFP-----ADRKRVEAALSACHLPKGK-NDAINPEDFPEPVYKS 210
+++ G I + N Q ++E H K K + E+F E ++
Sbjct: 280 -DVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHE- 337
Query: 211 FLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGL 270
LC RPEI + + + K ++ + L F+ +Q + +N + +
Sbjct: 338 ----LCTRPEIYFLLVQFSSN-KEFLDTKDLMMFLEAEQGVAHINEEISLE--------I 384
Query: 271 IDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTY 330
I KYEPS ++G LS +G +L P+ + + + DM QPL+HYFINSSHNTY
Sbjct: 385 IHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTY 444
Query: 331 LTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEA 390
L QF G S Y + L GCR VELD W G PD EP+I G TMT+ I F+ I+
Sbjct: 445 LIEDQFRGPSDITGYIRALKMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDI 502
Query: 391 IAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPS 450
I + AF S YP+IL ENH S +QQ M ++ + + GD L T P LPS
Sbjct: 503 INKYAFFASEYPLILCLENHC-SIKQQKVMVQHMKKLLGDKLYTTS----PNVEESYLPS 557
Query: 451 PEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEV 510
P+ L+GKILIK KK SS +G E G V +EG E+ + +
Sbjct: 558 PDVLKGKILIKAKK-------LSSNCSGVE-------------GDVTDEDEGAEMSQR-M 596
Query: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
+E E+ N+ +K+ Q +E+S LV+ + +F F+ S Q +
Sbjct: 597 GKENMEQPNNVP---VKRFQ-----------LCKELSELVSICKSVQFKEFQVSFQVQKY 642
Query: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
+ + SF E+ A ++ FV+YNKR ++R++P R+DSSN PQ FW GCQ+VA+
Sbjct: 643 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 702
Query: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
NFQT L M N+ F NG GY+L+ MR F+ + D + V L I +IS
Sbjct: 703 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 762
Query: 691 GQFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742
GQ + V YV VE+ G+P D + RTK + N P++ +E F F+
Sbjct: 763 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTK-TVHQNGDAPIF-DESFEFQ- 818
Query: 743 ILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
I +PELA +R V+++ G++F+G IP L +GY H+ L S + L +LF+
Sbjct: 819 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 876
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 305 bits (780), Expect = 2e-82
Identities = 246/778 (31%), Positives = 374/778 (48%), Gaps = 100/778 (12%)
Query: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104
L W K+ E +DI SI++ R GK + +S + D + D +V+ G
Sbjct: 46 LRWEPSKKDSEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDC--------AFSVIYG 97
Query: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPLTANAS-----RSTFLDKILVKLK 156
+ L + V+ +V W + L+ KH L S R++++ ++ ++
Sbjct: 98 ENYESL---DLVANSADVANIWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEI- 153
Query: 157 MQLNSEGKIPVKNFFQMFP-----ADRKRVEAALSACHLPKGK-NDAINPEDFPEPVYKS 210
+++ G I + N Q ++E H K K + E+F E ++
Sbjct: 154 -DVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHE- 211
Query: 211 FLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGL 270
LC RPEI + + + K ++ + L F+ +Q + +N + +
Sbjct: 212 ----LCTRPEIYFLLVQFSSN-KEFLDTKDLMMFLEAEQGVAHINEEISLE--------I 258
Query: 271 IDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTY 330
I KYEPS ++G LS +G +L P+ + + + DM QPL+HYFINSSHNTY
Sbjct: 259 IHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFINSSHNTY 318
Query: 331 LTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEA 390
L QF G S Y + L GCR VELD W G PD EP+I G TMT+ I F+ I+
Sbjct: 319 LIEDQFRGPSDITGYIRALKMGCRSVELDVWDG--PDNEPVIYTGHTMTSQIVFRSVIDI 376
Query: 391 IAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPS 450
I + AF S YP+IL ENH S +QQ M ++ + + GD L T P LPS
Sbjct: 377 INKYAFFASEYPLILCLENHC-SIKQQKVMVQHMKKLLGDKLYTTS----PNVEESYLPS 431
Query: 451 PEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEV 510
P+ L+GKILIK KK SS +G E G V +EG E+ + +
Sbjct: 432 PDVLKGKILIKAKK-------LSSNCSGVE-------------GDVTDEDEGAEMSQR-M 470
Query: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
+E E+ N+ +K+ Q +E+S LV+ + +F F+ S Q +
Sbjct: 471 GKENMEQPNNVP---VKRFQ-----------LCKELSELVSICKSVQFKEFQVSFQVQKY 516
Query: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
+ + SF E+ A ++ FV+YNKR ++R++P R+DSSN PQ FW GCQ+VA+
Sbjct: 517 WEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAM 576
Query: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
NFQT L M N+ F NG GY+L+ MR F+ + D + V L I +IS
Sbjct: 577 NFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIIS 636
Query: 691 GQFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEK 742
GQ + V YV VE+ G+P D + RTK + N P++ +E F F+
Sbjct: 637 GQNFPKPKGSGAKGDVVDPYVYVEIHGIPADCAEQ-RTK-TVHQNGDAPIF-DESFEFQ- 692
Query: 743 ILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
I +PELA +R V+++ G++F+G IP L +GY H+ L S + L +LF+
Sbjct: 693 INLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFV 750
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 297 bits (760), Expect = 5e-80
Identities = 211/619 (34%), Positives = 313/619 (50%), Gaps = 75/619 (12%)
Query: 195 NDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRL 254
ND + +++ + R EI EIF +Y K + +L +F+ Q+Q + +
Sbjct: 47 NDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRK-ILLASNLAQFLTQEQYAAEM 105
Query: 255 NSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDM 314
+ + +I KYEP + Q+S EG ++ E + + ++ DM
Sbjct: 106 SKAI--------AFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDM 157
Query: 315 TQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITH 374
T PLN YFI+SSHNTYL + Q G S Y L+ GCRC+E+DCW G EP++ H
Sbjct: 158 THPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLEIDCWDG--AQNEPVVYH 215
Query: 375 GFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLT 434
G+T+T+ + FK I+AI + AF TS YP++LS ENH S QQ MA+ + FG+ LL+
Sbjct: 216 GYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHC-STAQQEVMADNLQATFGESLLS 274
Query: 435 EPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEG 494
+ L+ FP LPSPE L+ KIL+KNKK + K+T E +GS
Sbjct: 275 DMLDDFP----DTLPSPEALKFKILVKNKK------IGTLKET-HERKGS---------- 313
Query: 495 TVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQ-----SDEGTAGLEVTAYEEMSSL 549
++ + +++E+G +KK+ + T L++ +S L
Sbjct: 314 -------------DKRGDNQDKETG------VKKLPGVMLFKKKKTRKLKIAL--ALSDL 352
Query: 550 VNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTR 609
V Y + KF SF+ S + +S E +A L +F+ + ++ ++RIYPK TR
Sbjct: 353 VIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATR 412
Query: 610 MDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFN 669
DSSN+ PQ FWN GCQMVALNFQT LPM F NG SGY+LK F+R FN
Sbjct: 413 ADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFN 472
Query: 670 PFSVDRIDVVVATTLSITVISGQFL-----SERSVRTYVEVELFGLPGDPKRRYRTKLSP 724
P I + TL+I +ISG L S + V +E+FG+P D ++ +
Sbjct: 473 P---SNIKEGMPITLTIRLISGIQLPLTHSSSNKGDSLVIIEVFGVPNDQMKQQTRVI-- 527
Query: 725 STNSINPVWKEEPFVFEKILMPELASLRVAV----MEEGNKFLGHRIIPINALNSGYHHL 780
N+ +P W E F F I +PELA +R V + GN+FLG +P+ +N GY +
Sbjct: 528 KKNAFSPRW-NETFTF-IIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRI 585
Query: 781 CLHSESNMPLTMPALFIFL 799
L S L +LF+++
Sbjct: 586 PLFSRMGESLEPASLFVYV 604
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 284 bits (727), Expect = 3e-76
Identities = 250/815 (30%), Positives = 360/815 (44%), Gaps = 183/815 (22%)
Query: 265 DQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFIN 324
+ Q +I+++EP N +G L +G + P + + +H DMTQPL+HYFI
Sbjct: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338
Query: 325 SSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFF 384
SSHNTYL Q S +MY VL +GCRCVE+DCW G PD EPI+ HG+T+T+ I F
Sbjct: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILF 396
Query: 385 KEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKP 444
K+ IE I + AF + YP+ILS ENH S QQ KMA+Y I GD L L +
Sbjct: 397 KDVIETINKYAFIKNEYPVILSIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSED 452
Query: 445 GVPLPSPEDLR------GKILIKNKKNQFSGPTSSSKDTGGEAE-------GSSPPSAPA 491
LPSP+ L+ GK L N S +D+ E + G + +
Sbjct: 453 ATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKR 512
Query: 492 GEGTVW----------------------------AGEEGTELE-EEEVEEEEE----EES 518
E T +G+ G + + EE+VE E+ +
Sbjct: 513 VENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRN 572
Query: 519 GNL----------DEEEIKKMQS-DEGTAGLEVTAYEE---------------MSSLVNY 552
G L ++KK S +EG G + + +S LV Y
Sbjct: 573 GRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKY 632
Query: 553 IQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDS 612
+ E A S+ +SSF+E KA+ +L + Q++ +N++Q+SRIYP R+DS
Sbjct: 633 TKSVATHDIEMEAAS--SWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDS 690
Query: 613 SNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFS 672
SNY PQ FWNAGCQMVALN+Q+ +Q N A F NG GY+LK M + FNP S
Sbjct: 691 SNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNS 748
Query: 673 VDRIDVVVATTLSITVISGQ--------FLSERS--VRTYVEVELFGLPGDPKRRYRTKL 722
D + + L + +ISGQ L +R + +VEVE+ GLP D R +T++
Sbjct: 749 EDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE-QTRV 807
Query: 723 SPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHH 779
N NP W EE VF + MPE+A +R V + G F+G R + +++ GY H
Sbjct: 808 -VDDNGFNPTW-EETLVF-MVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRH 864
Query: 780 LCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGG 839
+ L + ++F+ + + D S K+K+A+G
Sbjct: 865 VYLEG-----MEEASIFVHVAVSDI-------------------------SGKVKQALG- 893
Query: 840 LPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVV 899
K L P G+L + G P AR + ++ A T S
Sbjct: 894 --LKGLFLRGPKP----GSLDSHAAGRPPARPSVSQRILRRTASAPTKS----------- 936
Query: 900 KLQRRHEKELRELERRGARRWEELL-------QRGAAQLAELGPPGVGGV--GACKLGPG 950
++ G R + EL+ +G A ++ PPG G + GPG
Sbjct: 937 -------------QKPGRRGFPELVLGTRDTGSKGVAD--DVVPPGPGPAPEAPAQEGPG 981
Query: 951 KGSRK-------KRSLP-----REESAGAAPGEGP 973
GS + +R LP + APG GP
Sbjct: 982 SGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGP 1016
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 279 bits (714), Expect = 1e-74
Identities = 238/807 (29%), Positives = 368/807 (45%), Gaps = 106/807 (13%)
Query: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104
L W K++E LDI++I++ R GK + ++ L D D +++ G
Sbjct: 144 LRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC--------AFSILHG 195
Query: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPL-----TANASRSTFLDKILVKLK 156
+ L + V+ +V W + LV K PL N R +L +
Sbjct: 196 ENYESL---DLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAAD 252
Query: 157 MQLNSE--GKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDA---INPEDFPEPVYKSF 211
+ N V+ Q+ P K + L + K K + E+F E
Sbjct: 253 VDGNGIMLEDTSVELIKQLNPT-LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEA----- 306
Query: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
LC RPE+ + +K K Y+ L F+ +Q + + D +I
Sbjct: 307 FCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITE--------DICLDII 357
Query: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
+YE S Q+G L+ +G +L E + ++ + DMTQPL+HY+IN+SHNTYL
Sbjct: 358 RRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYL 417
Query: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
QF G + Y + L GCR VELD G D EPI+ + MTT + F+ IE I
Sbjct: 418 IEDQFRGPADINGYIRALKMGCRSVELDVSDGS--DNEPILCNRNNMTTHVSFRSVIEVI 475
Query: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
+ AF S YP+IL NH P+Q+ MA+ + +FG+ L TE PL LPSP
Sbjct: 476 NKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYLPSP 530
Query: 452 EDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVE 511
E L+ I++K KK PS P ++ E EV
Sbjct: 531 EKLKRMIIVKGKKL---------------------PSDP-------------DVLEGEVT 556
Query: 512 EEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSY 571
+E+EE E ++M D ++ E+S LV+ + ++ FE S + +
Sbjct: 557 DEDEEA------EMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYW 610
Query: 572 VISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALN 631
+ SF+E +A + ++ FV+YNK+ +SRIYP R+DSSN PQ FWN GCQ+VA+N
Sbjct: 611 EMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMN 670
Query: 632 FQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISG 691
FQT M + F NG GY+L+ MR F+ + + V L I +ISG
Sbjct: 671 FQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISG 730
Query: 692 QFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKI 743
Q + + YV +E+ G+P D + RTK + NS NP++ +E F F+ +
Sbjct: 731 QNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ-RTK-TVQQNSDNPIF-DETFEFQ-V 786
Query: 744 LMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLE 800
+PELA +R V+++ G++F+G IP L GY H+ L S + LF+ +
Sbjct: 787 NLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIA 846
Query: 801 MKDYIPGAWA---DLTVALANPIKFFS 824
+ + G A L+V + ++ ++
Sbjct: 847 ITNRSGGGKAQKRSLSVRMGKKVREYT 873
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 279 bits (714), Expect = 1e-74
Identities = 238/807 (29%), Positives = 368/807 (45%), Gaps = 106/807 (13%)
Query: 47 LYWTYQSKEMEF--LDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSG 104
L W K++E LDI++I++ R GK + ++ L D D +++ G
Sbjct: 46 LRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDC--------AFSILHG 97
Query: 105 PDMVDLTFHNFVSYKENVGKAWAEDVLALV---KHPL-----TANASRSTFLDKILVKLK 156
+ L + V+ +V W + LV K PL N R +L +
Sbjct: 98 ENYESL---DLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAAD 154
Query: 157 MQLNSE--GKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDA---INPEDFPEPVYKSF 211
+ N V+ Q+ P K + L + K K + E+F E
Sbjct: 155 VDGNGIMLEDTSVELIKQLNPT-LKEAKIRLKFKEIQKSKEKLTTRVTEEEFCEA----- 208
Query: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
LC RPE+ + +K K Y+ L F+ +Q + + D +I
Sbjct: 209 FCELCTRPEVYFLLVQI-SKNKEYLDANDLMLFLEAEQGVTHITE--------DICLDII 259
Query: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
+YE S Q+G L+ +G +L E + ++ + DMTQPL+HY+IN+SHNTYL
Sbjct: 260 RRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASHNTYL 319
Query: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
QF G + Y + L GCR VELD G D EPI+ + MTT + F+ IE I
Sbjct: 320 IEDQFRGPADINGYIRALKMGCRSVELDVSDGS--DNEPILCNRNNMTTHVSFRSVIEVI 377
Query: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
+ AF S YP+IL NH P+Q+ MA+ + +FG+ L TE PL LPSP
Sbjct: 378 NKFAFVASEYPLILCLGNHCSLPQQKV-MAQQMKKVFGNKLYTEA----PLPSESYLPSP 432
Query: 452 EDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVE 511
E L+ I++K KK PS P ++ E EV
Sbjct: 433 EKLKRMIIVKGKKL---------------------PSDP-------------DVLEGEVT 458
Query: 512 EEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSY 571
+E+EE E ++M D ++ E+S LV+ + ++ FE S + +
Sbjct: 459 DEDEEA------EMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYW 512
Query: 572 VISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALN 631
+ SF+E +A + ++ FV+YNK+ +SRIYP R+DSSN PQ FWN GCQ+VA+N
Sbjct: 513 EMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMN 572
Query: 632 FQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISG 691
FQT M + F NG GY+L+ MR F+ + + V L I +ISG
Sbjct: 573 FQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVSPLALHIKIISG 632
Query: 692 QFLSERS--------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKI 743
Q + + YV +E+ G+P D + RTK + NS NP++ +E F F+ +
Sbjct: 633 QNFPKPKGACAKGDVIDPYVCIEIHGIPADCSEQ-RTK-TVQQNSDNPIF-DETFEFQ-V 688
Query: 744 LMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLE 800
+PELA +R V+++ G++F+G IP L GY H+ L S + LF+ +
Sbjct: 689 NLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIA 748
Query: 801 MKDYIPGAWA---DLTVALANPIKFFS 824
+ + G A L+V + ++ ++
Sbjct: 749 ITNRSGGGKAQKRSLSVRMGKKVREYT 775
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 177 bits (450), Expect = 4e-44
Identities = 110/252 (43%), Positives = 139/252 (55%), Gaps = 9/252 (3%)
Query: 265 DQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLH-HDMTQPLNHYFI 323
D++ +I K+EPS +G +S EG FL EN D+ + ++ PL++Y+I
Sbjct: 1344 DEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYYYI 1403
Query: 324 NSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIF 383
SSHNTYLT Q G SS E+Y QVLL GCR VELDCW G D PII HG T+TT I
Sbjct: 1404 ESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDG--DDGMPIIYHGHTLTTKIP 1461
Query: 384 FKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLK 443
FKE +EAI SAF S PII+S ENH P QQ KMAE +T+FG+ L+T+ L +
Sbjct: 1462 FKEVVEAIDRSAFINSDLPIIISIENHCSLP-QQRKMAEIFKTVFGEKLVTKFLFETDFS 1520
Query: 444 PGVPLPSPEDLRGKILIKNKK-NQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEG 502
LPSP+ LR K+L+KNKK P K + + G A
Sbjct: 1521 DDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGN----ANPRP 1576
Query: 503 TELEEEEVEEEE 514
EEEE EE+E
Sbjct: 1577 ANNEEEEDEEDE 1588
Score = 134 bits (336), Expect = 7e-31
Identities = 99/262 (37%), Positives = 142/262 (54%), Gaps = 17/262 (6%)
Query: 543 YEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSR 602
+EE SS +N PT +S K Y ISS E A L + S + + Q+ R
Sbjct: 1732 WEESSSPLN---PTTSLSAIIRTPK--CYHISSLNENAAKRLCRRYSQKLTQHTACQLLR 1786
Query: 603 IYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMR 662
YP TR+DSSN P MFW G Q+VALN+QT DLP+ N A+FE NG GY+LK +
Sbjct: 1787 TYPAATRIDSSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLW 1846
Query: 663 RPD----KQFNPFSVDRIDVVVATTLSITVISGQFL--SERSVRTYVEVELFGLPGDPKR 716
+ ++F+P D +D + S+T++SGQ + S +EV++ G+P D
Sbjct: 1847 DKNCPMYQKFSPLERD-LDSMDPAVYSLTIVSGQNVCPSNSMGSPCIEVDVLGMPLD-SC 1904
Query: 717 RYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFL-GHRIIPINALNS 775
+RTK N++NP+W E+ F+F + +L LR AV+E + + RIIP+ AL
Sbjct: 1905 HFRTK-PIHRNTLNPMWNEQ-FLFH-VHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKR 1961
Query: 776 GYHHLCLHSESNMPLTMPALFI 797
GY HL L + N L + +LFI
Sbjct: 1962 GYRHLQLRNLHNEVLEISSLFI 1983
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 169 bits (428), Expect = 1e-41
Identities = 100/253 (39%), Positives = 146/253 (57%), Gaps = 17/253 (6%)
Query: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
+MSL R ++ + SY K K ++T E L +F+ +Q+ + + + D +I
Sbjct: 210 MMSL--RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQKMNNVTT--------DYCLDII 258
Query: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
K+E S N + L EG F+ P + ++ DM QPL +Y+I SSHNTYL
Sbjct: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318
Query: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
T Q S +MY +VL GCRCVE+DCW G PD EP++ HG+T+T+ I F++ +E I
Sbjct: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETI 376
Query: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
+ AF + +P+ILS ENH S +QQ K+A+Y + IFGD L ++ K LPSP
Sbjct: 377 NKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPSP 432
Query: 452 EDLRGKILIKNKK 464
+ L+GKIL+K KK
Sbjct: 433 QSLKGKILVKGKK 445
Score = 152 bits (383), Expect = 2e-36
Identities = 125/413 (30%), Positives = 204/413 (49%), Gaps = 39/413 (9%)
Query: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
+EE+ ++S + ++ ++ T L E+S LV Y T V+ + +
Sbjct: 570 DEEDTQQSTGKEGGQLYRLGRRRKTMKL----CRELSDLVVY---TNSVAAQDIVDDGTT 622
Query: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
+ SF+E +A+ ++ + S QF+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+VAL
Sbjct: 623 GNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682
Query: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
N+Q+ MQ N A F+ NG GY+LK + M + FNPFS D + L + VIS
Sbjct: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVIS 740
Query: 691 GQFLSE----------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF 740
GQ L + + +VEVE+ GLP D + +T++ N NPVW EE F
Sbjct: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD-QTRV-VDDNGFNPVW-EETLTF 797
Query: 741 EKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
+ MPE+A +R V + G F+G R + ++L GY H+ L LT ++F+
Sbjct: 798 -TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFV 851
Query: 798 FLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVAS---- 853
+ + + I G W+ L + + I F TK+ +L+ G + P +S S
Sbjct: 852 HITINE-IYGKWSPLILNPSYTILHFLG-ATKNRQLQGLKGLFNKNPRHSSSENNSHYVR 909
Query: 854 --QVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRR 904
+ + + +PA + +E E + + E R+ GV++ R
Sbjct: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTR 962
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 169 bits (428), Expect = 1e-41
Identities = 100/253 (39%), Positives = 146/253 (57%), Gaps = 17/253 (6%)
Query: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
+MSL R ++ + SY K K ++T E L +F+ +Q+ + + + D +I
Sbjct: 210 MMSL--RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQKMNNVTT--------DYCLDII 258
Query: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
K+E S N + L EG F+ P + ++ DM QPL +Y+I SSHNTYL
Sbjct: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318
Query: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
T Q S +MY +VL GCRCVE+DCW G PD EP++ HG+T+T+ I F++ +E I
Sbjct: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETI 376
Query: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
+ AF + +P+ILS ENH S +QQ K+A+Y + IFGD L ++ K LPSP
Sbjct: 377 NKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPSP 432
Query: 452 EDLRGKILIKNKK 464
+ L+GKIL+K KK
Sbjct: 433 QSLKGKILVKGKK 445
Score = 152 bits (383), Expect = 2e-36
Identities = 125/413 (30%), Positives = 204/413 (49%), Gaps = 39/413 (9%)
Query: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
+EE+ ++S + ++ ++ T L E+S LV Y T V+ + +
Sbjct: 570 DEEDTQQSTGKEGGQLYRLGRRRKTMKL----CRELSDLVVY---TNSVAAQDIVDDGTT 622
Query: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
+ SF+E +A+ ++ + S QF+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+VAL
Sbjct: 623 GNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682
Query: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
N+Q+ MQ N A F+ NG GY+LK + M + FNPFS D + L + VIS
Sbjct: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVIS 740
Query: 691 GQFLSE----------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF 740
GQ L + + +VEVE+ GLP D + +T++ N NPVW EE F
Sbjct: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD-QTRV-VDDNGFNPVW-EETLTF 797
Query: 741 EKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
+ MPE+A +R V + G F+G R + ++L GY H+ L LT ++F+
Sbjct: 798 -TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFV 851
Query: 798 FLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVAS---- 853
+ + + I G W+ L + + I F TK+ +L+ G + P +S S
Sbjct: 852 HITINE-IYGKWSPLILNPSYTILHFLG-ATKNRQLQGLKGLFNKNPRHSSSENNSHYVR 909
Query: 854 --QVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRR 904
+ + + +PA + +E E + + E R+ GV++ R
Sbjct: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTR 962
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 169 bits (428), Expect = 1e-41
Identities = 100/253 (39%), Positives = 146/253 (57%), Gaps = 17/253 (6%)
Query: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
+MSL R ++ + SY K K ++T E L +F+ +Q+ + + + D +I
Sbjct: 192 MMSL--RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQKMNNVTT--------DYCLDII 240
Query: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
K+E S N + L EG F+ P + ++ DM QPL +Y+I SSHNTYL
Sbjct: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
Query: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
T Q S +MY +VL GCRCVE+DCW G PD EP++ HG+T+T+ I F++ +E I
Sbjct: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETI 358
Query: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
+ AF + +P+ILS ENH S +QQ K+A+Y + IFGD L ++ K LPSP
Sbjct: 359 NKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPSP 414
Query: 452 EDLRGKILIKNKK 464
+ L+GKIL+K KK
Sbjct: 415 QSLKGKILVKGKK 427
Score = 145 bits (366), Expect = 2e-34
Identities = 103/306 (33%), Positives = 163/306 (53%), Gaps = 31/306 (10%)
Query: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
+EE+ ++S + ++ ++ T L E+S LV Y T V+ + +
Sbjct: 552 DEEDTQQSTGKEGGQLYRLGRRRKTMKL----CRELSDLVVY---TNSVAAQDIVDDGTT 604
Query: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
+ SF+E +A+ ++ + S QF+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+VAL
Sbjct: 605 GNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 664
Query: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
N+Q+ MQ N A F+ NG GY+LK + M + FNPFS D + L + VIS
Sbjct: 665 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVIS 722
Query: 691 GQFLSE----------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF 740
GQ L + + +VEVE+ GLP D + +T++ N NPVW EE F
Sbjct: 723 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD-QTRV-VDDNGFNPVW-EETLTF 779
Query: 741 EKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
+ MPE+A +R V + G F+G R + ++L GY H+ L LT ++F+
Sbjct: 780 -TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFV 833
Query: 798 FLEMKD 803
+ + +
Sbjct: 834 HITINE 839
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 155 bits (391), Expect = 3e-37
Identities = 105/260 (40%), Positives = 131/260 (50%), Gaps = 38/260 (14%)
Query: 292 VWFLCGPENSVL-AQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLL 350
V FL ENSV +Q + M PL+HY+I+SSHNTYLT QFS SS E Y + L
Sbjct: 299 VTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLR 358
Query: 351 SGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENH 410
GCRC+ELDCW G PD P+I HG T+TT I F + + I E AF S YP+ILS E+H
Sbjct: 359 MGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDH 416
Query: 411 VDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGP 470
S QQ MA+Y + + GD LLT+P+E LPSP L+ KILIK+KK
Sbjct: 417 C-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHKKL----- 466
Query: 471 TSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEE-------------------VE 511
G A P S E + + L E+
Sbjct: 467 ------AEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYS 520
Query: 512 EEEEEESGNLDEEEIKKMQS 531
EE + GN DEEE K++ S
Sbjct: 521 EETSSDQGNEDEEEPKEVSS 540
Score = 147 bits (372), Expect = 4e-35
Identities = 97/265 (36%), Positives = 142/265 (53%), Gaps = 13/265 (4%)
Query: 545 EMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKAS-VQFVDYNKRQMSRI 603
E+S LV Y +P F + ++ +SSF E KA ++KA +F+ YN+ Q+SRI
Sbjct: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
Query: 604 YPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRR 663
YPKG R+DSSNY P W G Q+VALNFQT D PMQ N A+F GY+L+ MR
Sbjct: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
Query: 664 PDKQFNPFSVDRIDVVVATTLSITVISGQFLSERS---VRTYVEVELFGLPGDPKRRYRT 720
D+ F+PF + + +SI V+ + L + V +VE+E+ G D ++ +T
Sbjct: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ-KT 1128
Query: 721 KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEE----GNKFLGHRIIPINALNSG 776
+ N +NPVW +PF F+ I PE A LR V EE FL P+ L +G
Sbjct: 1129 EFVVD-NGLNPVWPAKPFHFQ-ISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
Query: 777 YHHLCLHSESNMPLTMPALFIFLEM 801
Y + L + + L + +L I +++
Sbjct: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 155 bits (391), Expect = 3e-37
Identities = 105/260 (40%), Positives = 131/260 (50%), Gaps = 38/260 (14%)
Query: 292 VWFLCGPENSVL-AQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLL 350
V FL ENSV +Q + M PL+HY+I+SSHNTYLT QFS SS E Y + L
Sbjct: 299 VTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLR 358
Query: 351 SGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENH 410
GCRC+ELDCW G PD P+I HG T+TT I F + + I E AF S YP+ILS E+H
Sbjct: 359 MGCRCIELDCWDG--PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDH 416
Query: 411 VDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGP 470
S QQ MA+Y + + GD LLT+P+E LPSP L+ KILIK+KK
Sbjct: 417 C-SIAQQRNMAQYFKKVLGDTLLTKPVE----ISADGLPSPNQLKRKILIKHKKL----- 466
Query: 471 TSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEE-------------------VE 511
G A P S E + + L E+
Sbjct: 467 ------AEGSAYEEVPTSMMYSENDISNSIKNGILYLEDPVNHEWYPHYFVLTSSKIYYS 520
Query: 512 EEEEEESGNLDEEEIKKMQS 531
EE + GN DEEE K++ S
Sbjct: 521 EETSSDQGNEDEEEPKEVSS 540
Score = 147 bits (372), Expect = 4e-35
Identities = 97/265 (36%), Positives = 142/265 (53%), Gaps = 13/265 (4%)
Query: 545 EMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKAS-VQFVDYNKRQMSRI 603
E+S LV Y +P F + ++ +SSF E KA ++KA +F+ YN+ Q+SRI
Sbjct: 952 ELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQLSRI 1011
Query: 604 YPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRR 663
YPKG R+DSSNY P W G Q+VALNFQT D PMQ N A+F GY+L+ MR
Sbjct: 1012 YPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPSTMR- 1070
Query: 664 PDKQFNPFSVDRIDVVVATTLSITVISGQFLSERS---VRTYVEVELFGLPGDPKRRYRT 720
D+ F+PF + + +SI V+ + L + V +VE+E+ G D ++ +T
Sbjct: 1071 -DEAFDPFDKSSLRGLEPCAISIEVLGARHLPKNGRGIVCPFVEIEVAGAEYDSTKQ-KT 1128
Query: 721 KLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEE----GNKFLGHRIIPINALNSG 776
+ N +NPVW +PF F+ I PE A LR V EE FL P+ L +G
Sbjct: 1129 EFVVD-NGLNPVWPAKPFHFQ-ISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTG 1186
Query: 777 YHHLCLHSESNMPLTMPALFIFLEM 801
Y + L + + L + +L I +++
Sbjct: 1187 YRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 150 bits (380), Expect = 5e-36
Identities = 79/152 (51%), Positives = 100/152 (65%), Gaps = 7/152 (4%)
Query: 313 DMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPII 372
DM PL+HY+I+SSHNTYLT Q SS E Y + L GCRC+ELDCW G PD +P+I
Sbjct: 313 DMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDG--PDGKPVI 370
Query: 373 THGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDML 432
HG+T TT I F + ++AI + AF TS +P+ILS E H S QQ MA+ + +FGD+L
Sbjct: 371 YHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHC-SVEQQRHMAKAFKEVFGDLL 429
Query: 433 LTEPLEKFPLKPGVPLPSPEDLRGKILIKNKK 464
LT+P E LPSP LR KI+IK+KK
Sbjct: 430 LTKPTE----ASADQLPSPSQLREKIIIKHKK 457
Score = 141 bits (355), Expect = 4e-33
Identities = 96/267 (35%), Positives = 146/267 (54%), Gaps = 17/267 (6%)
Query: 545 EMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIY 604
E+S LV Y +PT R I SF E KA ++ + V + YN++ ++R+Y
Sbjct: 929 ELSDLVVYCKPTSKTKDNLENPDFRE--IRSFVETKADSIIRQKPVDLLKYNQKGLTRVY 986
Query: 605 PKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRP 664
PKG R+DSSNY P W G QMVALNFQT D MQ N A+F NG++GY+L+ E MR
Sbjct: 987 PKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMR-- 1044
Query: 665 DKQFNPFSVDRIDVVVATTLSITVISGQFLSE--RSVR-TYVEVELFGLPGDPKRRYRTK 721
++++P + + TL++ V+ + L + RS+ +VEVE+ G D +++T
Sbjct: 1045 TEKYDPMPPES-QRKILMTLTVKVLGARHLPKLGRSIACPFVEVEICGAEYD-NNKFKTT 1102
Query: 722 LSPSTNSINPVW--KEEPFVFEKILMPELASLRVAVMEE----GNKFLGHRIIPINALNS 775
+ + N ++P+W +E FE I P LA LR V EE FL H PI A+ S
Sbjct: 1103 V-VNDNGLSPIWAPTQEKVTFE-IYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKS 1160
Query: 776 GYHHLCLHSESNMPLTMPALFIFLEMK 802
G+ + L + + + + +L +F EM+
Sbjct: 1161 GFRSVPLKNGYSEDIELASLLVFCEMR 1187
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 62.4 bits (150), Expect = 2e-09
Identities = 71/285 (24%), Positives = 131/285 (45%), Gaps = 32/285 (11%)
Query: 874 REEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAE 933
RE+ +K E R L+ E + + +RR ++ R+ E RW +L + + E
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQ-ERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 934 LGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLR 993
+L + R+++ L R+E E + R+R E +L R
Sbjct: 502 RREQ--------QLRREQEERREQRLKRQEEE--------ERLQQRLRS-----EQQLRR 540
Query: 994 QGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLE 1053
+ EE+ E +LKR+E+ EQ + L RE++ + LK E + +K++ E + +
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 1054 RI--QGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQ 1111
R+ + + ++ ++ ++RLKRE +E Q + + E ER Q++L +Q EQ
Sbjct: 601 RLKREEVERLEQEERREQRLKRE---EPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 1112 --IREMEKQFQKEALA---EYEARMKGLEAEVKESVRACLRTCFP 1151
RE E++ ++ L E E R + L E +E R +++ P
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP 702
Score = 54.3 bits (129), Expect = 7e-07
Identities = 62/270 (22%), Positives = 119/270 (44%), Gaps = 30/270 (11%)
Query: 875 EEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAEL 934
E+ ++ E + EEL++ + + + R ++ +E ER+ R+ +EL Q L E
Sbjct: 979 EKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ-YRKKDELQQEEEQLLRE- 1036
Query: 935 GPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGE---GPEGVDGRVRELKDRLELEL 991
R+KR L E E E + G RE + R ELE
Sbjct: 1037 ------------------EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 992 LRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKR 1051
+ EE+ + + +EQ + E+ K RE+Q E + L++ E +E ++K +
Sbjct: 1079 QYRKEEELQ---QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Query: 1052 LERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQ 1111
LER Q + + ++ L+ E QE+ + ++ E + ++ L E+Q ++
Sbjct: 1136 LER-QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQE---KR 1191
Query: 1112 IREMEKQFQKEALAEYEARMKGLEAEVKES 1141
+E E+Q+++E + + R + E + S
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRS 1221
Score = 53.1 bits (126), Expect = 2e-06
Identities = 61/251 (24%), Positives = 110/251 (43%), Gaps = 39/251 (15%)
Query: 890 EELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGP 949
EE RE + + Q R E+E R +R + EE LQ+ +L
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE------------ 541
Query: 950 GKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQH 1009
+ R+++ L REE R ++R E L R+ EE+ + +LKR+E+
Sbjct: 542 -QEERREQLLKREEEK---------------RLEQERREQRLKREQEERRDQLLKREEER 585
Query: 1010 VAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTT-DKMAQ 1068
+++ + E R +Q + + ++ + + +E + K E ER Q + K ++ Q
Sbjct: 586 RQQRLKREQE-ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 1069 ERLKREINNSHIQ---------EVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQF 1119
++L+RE Q + Q +K+ E R QE EE+Q E+I+ ++
Sbjct: 645 QQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704
Query: 1120 QKEALAEYEAR 1130
Q + +E +AR
Sbjct: 705 QWQLESEADAR 715
Score = 51.6 bits (122), Expect = 4e-06
Identities = 65/290 (22%), Positives = 118/290 (40%), Gaps = 43/290 (14%)
Query: 864 NGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRE----------LE 913
+G + R+E + EPR LEE + K Q + E+EL E LE
Sbjct: 104 DGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQ-ERELAEGEEQSEKQERLE 162
Query: 914 RRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGP 973
+R +R +E L R + E R++R E+ E
Sbjct: 163 QRDRQRRDEELWRQRQEWQE--------------------REERRAEEEQLQSCKGHETE 202
Query: 974 EGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALK 1033
E D +L+ R LEL R+G E+ K+Q E+ ++ + EK+ + + +
Sbjct: 203 EFPDEE--QLRRRELLELRRKGREE-------KQQQRRERQDRVFQEEEEKEWRKRETVL 253
Query: 1034 ETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTEN 1093
E +E + + + + E + + K+ ++ +ER + E ++ Q+ ++ E
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 1094 LERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVR 1143
QE+ E+Q +Q E+Q ++E + E R + L E +E R
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRRE---QEERREQQLRREQEEERR 360
Score = 50.8 bits (120), Expect = 7e-06
Identities = 74/330 (22%), Positives = 136/330 (41%), Gaps = 30/330 (9%)
Query: 874 REEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGAR---RWEELLQRGAAQ 930
++E ++ E R L +E + +L+R E+E RE + R + R E+ L+R
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 931 LAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELE 990
E +L + R+++ L RE+ E R ++L+ E E
Sbjct: 384 RREQ-----------QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 991 LLRQGEEQY--ECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLE 1048
Q EQ E LKR+++ + + + E R +Q + LK E + +E KLE
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLE 492
Query: 1049 TKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEK-----LEE 1103
+ Q + + +ER ++ + +E +Q + + L R QE+ L+
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Query: 1104 KQAACLEQ-------IREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKD 1156
++ LEQ RE E++ + E E R + L+ E +E + L+ +
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQ 612
Query: 1157 KPERACECPPELCEQD--PLIAKADAQESR 1184
+ R E E++ + K++ QE R
Sbjct: 613 EERREQRLKREEPEEERRQQLLKSEEQEER 642
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/295 (20%), Positives = 137/295 (46%), Gaps = 15/295 (5%)
Query: 870 RAGAREEAMKEAAE--PRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRG 927
R REE ++ E R EE +E + + R+ E++L+E E + R LQ
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE----LQEE 274
Query: 928 AAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPR--EESAGAAPGEGPEGVDGRVRELKD 985
QL +L + + + R+++ L R EE E E + R ++ ++
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ-EE 333
Query: 986 RLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKK 1045
R E +L R+ EE+ E L+R+++ E+ + + +E++ E + +E +++++
Sbjct: 334 RREQQLRREQEERREQQLRREQEE--ERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 1046 KLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQ 1105
+ + +R ++++ ++ + ++L+RE Q++ + ++ + QE+ E++
Sbjct: 392 EQQLRREQQLRREQQLRRE----QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447
Query: 1106 AACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPER 1160
E+ R+ K+ ++ E E R + L+ + +E R E +++ ER
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502
Score = 46.6 bits (109), Expect = 1e-04
Identities = 62/315 (19%), Positives = 131/315 (41%), Gaps = 40/315 (12%)
Query: 875 EEAMKEAAEPRTASLEELRELKGVVKLQ-----RRHEKELRELERRGARRWEELLQRGAA 929
E+ ++E E R S E+ R+ K +L+ RRH + + R+ ++LLQ
Sbjct: 853 EDGLQEDQE-RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 930 QLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLEL 989
+L + R+KR +E + + + +RE +++
Sbjct: 912 ELQ------------------REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRR 953
Query: 990 ELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLET 1049
+ + + + + +++EQ + E+ K REK+ E + L++ E +E ++K
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 1050 KRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACL 1109
+ ER Q K + ++ L+ E +QE E R +E+L++++ L
Sbjct: 1014 QEWER-QYRKKDELQQEEEQLLREEREKRRLQE--------RERQYREEEELQQEEEQLL 1064
Query: 1110 EQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELC 1169
+ RE ++ + E R E E+++ LR + + ER C EL
Sbjct: 1065 GEERETRRRQELE-------RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQ 1117
Query: 1170 EQDPLIAKADAQESR 1184
+++ + + + ++ R
Sbjct: 1118 QEEEQLLREEREKRR 1132
Score = 45.8 bits (107), Expect = 2e-04
Identities = 62/269 (23%), Positives = 114/269 (42%), Gaps = 9/269 (3%)
Query: 870 RAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELREL----ERRGARRWEELLQ 925
R R+E +E AE S E +E QRR E+ R+ ER R EE LQ
Sbjct: 137 RRQKRQEQERELAEGEEQS--EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 926 RGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKD 985
E P L + R+++ R E E E + R RE
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK-EWRKRETVL 253
Query: 986 RLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKK 1045
R E E L++ E Q + L+ +E+ + + + + R+++ + + L+ + K+ ++
Sbjct: 254 RKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 1046 KLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEV--VQVIKQMTENLERHQEKLEE 1103
+ E + R Q + ++ +++L+RE Q++ Q ++ + L R QE+
Sbjct: 314 RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373
Query: 1104 KQAACLEQIREMEKQFQKEALAEYEARMK 1132
+Q EQ E+Q ++E E +++
Sbjct: 374 EQQLRREQQLRREQQLRREQQLRREQQLR 402
Score = 40.8 bits (94), Expect = 0.008
Identities = 62/287 (21%), Positives = 120/287 (41%), Gaps = 30/287 (10%)
Query: 875 EEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAEL 934
EE +E E R +E R+ + +LQ+ E+ LRE + R+ E R +L +
Sbjct: 911 EELQREEREKRRRQEQE-RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 935 GPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQ 994
+G P K R++R E E + R + + E + ++
Sbjct: 970 EEQLLGEE------PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 995 GEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSEN---DTKEMKKKLETKR 1051
E Q E +EQ + E+ K RE+Q E + L++ E + +E +++ E +R
Sbjct: 1024 DELQQE-----EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Query: 1052 LERIQGMTKVTTDKMAQE------RLKREINNSHIQEVVQVIKQMT---------ENLER 1096
R + + +++ +E R +RE +E+ Q +Q+ + LER
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Query: 1097 HQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVR 1143
+ EE Q + +RE ++ +++ L + L+ E ++ +R
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLR 1185
Score = 38.9 bits (89), Expect = 0.029
Identities = 63/317 (19%), Positives = 133/317 (41%), Gaps = 30/317 (9%)
Query: 874 REEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELE-RRGARRWEELLQRGAAQLA 932
REE E LEE ++L+ + ++ E+ELR E R E+ L R Q
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ-- 1530
Query: 933 ELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELL 992
K ++++ L R+E G + + +L+ E + L
Sbjct: 1531 -----------------RKFLQEEQQLRRQE-RGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Query: 993 RQGEEQYECVLKRKEQHVAEQISKMME----LAREKQAAELKALKETSENDTKEMKKKLE 1048
+ E + L+ ++ EQ K ME L R++ +L+ ++ + +++ ++ E
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Query: 1049 TKRLERIQGMTKVTTDKMAQERLKREINNSHIQE-VVQVIKQMTENLERHQEKLEEKQAA 1107
++L R + K ++ R +RE H ++ + +Q+ + E Q + +E+
Sbjct: 1633 EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 1108 CLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPE 1167
E+ +++ +Q ++ + E +++ E E K LR E + + R E +
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLR----QETEQEQLRRQERYRK 1748
Query: 1168 LCEQDPLIAKADAQESR 1184
+ E++ L + + Q+ R
Sbjct: 1749 ILEEEQLRPEREEQQLR 1765
Score = 37.4 bits (85), Expect = 0.085
Identities = 38/164 (23%), Positives = 83/164 (50%), Gaps = 14/164 (8%)
Query: 981 RELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDT 1040
R+ K R E +LL++GEEQ L+R+E+ ++ + E +Q E K L+E +
Sbjct: 1665 RDRKFREEEQLLQEGEEQQ---LRRQER---DRKFREEEQQLRRQERERKFLQE----EQ 1714
Query: 1041 KEMKKKLETKRLERIQGMTKVTTDKM-AQERLKREINNSHI---QEVVQVIKQMTENLER 1096
+ +++LE K E Q + +++ QER ++ + + +E Q+ +Q + R
Sbjct: 1715 QLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFR 1774
Query: 1097 HQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
+E+L +++ + +E +++F++E E + L + ++
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRD 1818
Score = 36.2 bits (82), Expect = 0.19
Identities = 46/200 (23%), Positives = 88/200 (44%), Gaps = 20/200 (10%)
Query: 955 KKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQ------YECVLKRKEQ 1008
K+R +E E E + + K R E +LL++ EEQ + + +E
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL 1367
Query: 1009 HVAEQISKMMELARE--KQAAELKALKETSENDTKEMKKKLETKR----LERIQGMTKVT 1062
EQ K +E + +Q E K LKE + +E +++L R E Q +++
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Query: 1063 TDKMAQE---RLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQF 1119
D+ +E +++R+ E Q ++Q ERH++ EE+Q + +++ +Q
Sbjct: 1428 RDRKFREEEQQVRRQERERKFLEEEQQLRQ-----ERHRKFREEEQLLQEREEQQLHRQE 1482
Query: 1120 QKEALAEYEARMKGLEAEVK 1139
+ E E +++ E + K
Sbjct: 1483 RDRKFLEEEQQLRRQERDRK 1502
Score = 35.8 bits (81), Expect = 0.25
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 46/272 (16%)
Query: 874 REEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELR---ELERRGARRWEELLQRGAAQ 930
REE K + R E EL+ + R E+E R ELER+ R EE +Q+ Q
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ--YREEEEVQQEEEQ 1152
Query: 931 LAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELE 990
L P R+++ L R+ + E + +RE +++ E
Sbjct: 1153 LLREEPE---------------KRRRQELERQYREEEELQQEEEQL---LREEQEKRRQE 1194
Query: 991 LLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELK----ALKETSENDTKEMKKK 1046
RQ E+ E ++++Q + E Q ++LK KE + D K K
Sbjct: 1195 RERQYREEEELQRQKRKQRYRD----------EDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 1047 LETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERH------QEK 1100
E ++ +++ D+ +Q+ L+ + ++ Q ++ + +RH E+
Sbjct: 1245 RENEQFRQLEDSQ--LRDRQSQQDLQHLLGEQQERDREQERRRWQQR-DRHFPEEEQLER 1301
Query: 1101 LEEKQAACLEQIREMEKQFQKEALAEYEARMK 1132
E+K+A ++ + EKQ +E E R +
Sbjct: 1302 EEQKEAKRRDRKSQEEKQLLREEREEKRRRQE 1333
Score = 33.5 bits (75), Expect = 1.2
Identities = 50/275 (18%), Positives = 106/275 (38%), Gaps = 23/275 (8%)
Query: 869 ARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGA 928
+ A AR+ K + PR + R+ + + +R E + +E ER ++ EE +R
Sbjct: 710 SEADARQS--KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767
Query: 929 AQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLE 988
+ G P +++R L EE + + E
Sbjct: 768 TWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE--------------------RQQRE 807
Query: 989 LELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLE 1048
L + EE+ + +R+E+ Q + E + ++ A+ +E + +E ++ E
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 1049 TKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAAC 1108
+R ++ + + + + +++ Q++++ E L+R + + +Q
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ- 926
Query: 1109 LEQIREMEKQFQKEALAEYEARMKGLEAEVKESVR 1143
Q RE E+ Q+E E R K E + R
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Score = 31.6 bits (70), Expect = 4.7
Identities = 42/184 (22%), Positives = 77/184 (41%), Gaps = 25/184 (13%)
Query: 875 EEAMKEAAEPRTASLEELRELKGVVKLQ-RRHEKELRELER-RGARRWEELLQRGAAQLA 932
E+ +E + + E R++ +L+ R E++LR ER R R E+L Q Q
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQ-- 1786
Query: 933 ELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELL 992
+L + RK R + P+ DG+ R +++L+LE
Sbjct: 1787 -------------QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE-- 1831
Query: 993 RQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRL 1052
E++ +R Q+ AE+ E +R + E + +E + +E ++KL + +
Sbjct: 1832 ---EQEQRLRQERDRQYRAEEQFATQEKSRRE---EQELWQEEEQKRRQERERKLREEHI 1885
Query: 1053 ERIQ 1056
R Q
Sbjct: 1886 RRQQ 1889
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sapiens]
Length = 570
Score = 61.6 bits (148), Expect = 4e-09
Identities = 62/268 (23%), Positives = 126/268 (47%), Gaps = 24/268 (8%)
Query: 874 REEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAE 933
+EE ++E E E++RE + + RR E+ + E E + RR EE++ ++ E
Sbjct: 293 QEEKIQEREEKIQEQEEKIREQE---EKMRRQEEMMWEKEEK-MRRQEEMMWEKEEKIRE 348
Query: 934 LGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRV--RELKDRLELEL 991
L K+ + R++ R+E E + + ++ +E K R + E
Sbjct: 349 LEE---------KMHEQEKIREQEE-KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 398
Query: 992 LRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKR 1051
+R+ EE +++ +E+ + EQ KM E E Q E K ++ + +E K + + ++
Sbjct: 399 IREQEE----MMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEK 454
Query: 1052 LERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQ 1111
+ + M + +KM ++ K + +QE + +++ E + ++K+ E++ E+
Sbjct: 455 IREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE----EK 510
Query: 1112 IREMEKQFQKEALAEYEARMKGLEAEVK 1139
IRE E+ Q++ +E K E E K
Sbjct: 511 IREQEEMMQEQEEKMWEQEEKMCEQEEK 538
Score = 48.1 bits (113), Expect = 5e-05
Identities = 71/320 (22%), Positives = 143/320 (44%), Gaps = 26/320 (8%)
Query: 871 AGAREEAMKEAAEPRTAS---LEELRELKGVVKLQR-RHEKELRELERRGARRWEELLQR 926
AG E+A+ A + + +EEL + + + L+ R+ EL+ + A+ E+L
Sbjct: 162 AGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKL--- 218
Query: 927 GAAQLAELGPPGVG-GVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKD 985
QL E + V K K R K LP+++ A G E +
Sbjct: 219 ---QLVESEKSEIQLNVKELKR---KLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 272
Query: 986 RLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKK 1045
E EL + +Q E + R+E+ + E+ K+ E + + E K ++ KE K
Sbjct: 273 VEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332
Query: 1046 KLETKRLERIQGMTKVTTDKM-AQERLKREINNSHIQEVVQVIKQMTEN---LERHQEKL 1101
+ + + + + + +KM QE+++ + +E ++ ++ E + R +EK+
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 392
Query: 1102 EEKQAACLEQIREMEK--QFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPE 1159
E++ E+IRE E+ Q Q+E + E E +M E E++E R + +++ +
Sbjct: 393 REQE----EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQ--EEKIREQEK 446
Query: 1160 RACECPPELCEQDPLIAKAD 1179
+ E ++ EQ+ ++ + +
Sbjct: 447 KIREQEEKIREQEEMMQEQE 466
Score = 36.6 bits (83), Expect = 0.15
Identities = 38/189 (20%), Positives = 81/189 (42%), Gaps = 34/189 (17%)
Query: 865 GSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELL 924
G + +EE M+E E E++RE EK++RE E + R EE++
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMRRQEEKIRE----------QEKKIREQEEK-IREQEEMM 462
Query: 925 QRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELK 984
Q ++ E GK ++ + +E E + ++RE +
Sbjct: 463 QEQEEKMGE--------------QEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQE 508
Query: 985 DRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMK 1044
++ +R+ EE +++ +E+ + EQ KM E + Q E K ++ + +E++
Sbjct: 509 EK-----IREQEE----MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVR 559
Query: 1045 KKLETKRLE 1053
+ + ++++
Sbjct: 560 LRQQEEKMQ 568
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 57.4 bits (137), Expect = 8e-08
Identities = 70/294 (23%), Positives = 126/294 (42%), Gaps = 31/294 (10%)
Query: 866 SPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQ 925
SP + + +K TA +LR LK R R R A
Sbjct: 105 SPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGV---- 160
Query: 926 RGAAQLAELGPPGVGGVGACKLGPGKGSRKKRS--------LPREESAGA-----APGEG 972
A + LGP G G +L + S ++ P S GA +P +
Sbjct: 161 --AGASSSLGPSGSASAG--ELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKE 216
Query: 973 PEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKAL 1032
EG+ +VR+L+++LE L++ E++ + K + EQ+ + +E+QA + L
Sbjct: 217 EEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 276
Query: 1033 KETSE--NDTKEMKKKLETKRLERIQGMTKVTTDK-MAQERLKREINNSHIQEVVQVIKQ 1089
KE + + E K++ + + + T DK MA+ER E ++ + + + +
Sbjct: 277 KEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER--AESLQQEVEALKERVDE 334
Query: 1090 MTENLERHQEKLEEK---QAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
+T +LE + ++EEK AA Q++++E+ Q L + RM+ L + K+
Sbjct: 335 LTTDLEILKAEIEEKGSDGAASSYQLKQLEE--QNARLKDALVRMRDLSSSEKQ 386
Score = 37.4 bits (85), Expect = 0.085
Identities = 61/269 (22%), Positives = 113/269 (42%), Gaps = 38/269 (14%)
Query: 873 AREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLA 932
AR+EA KEA E + +EE+ + + E+ L++ A E LQ+ L
Sbjct: 279 ARKEA-KEALEAKERYMEEMADTADAI--------EMATLDKEMAEERAESLQQEVEALK 329
Query: 933 ELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELL 992
E + K + + S GAA + ++ + LKD L
Sbjct: 330 ERVDELTTDLEILKA----------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 379
Query: 993 RQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRL 1052
E+ E V K Q + E+ ++ +E+ R+ Q L+ +E+ E+K++++
Sbjct: 380 LSSSEKQEHV---KLQKLMEKKNQELEVVRQ-QRERLQEELSQAESTIDELKEQVDAAL- 434
Query: 1053 ERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQ- 1111
+ M ++ TD+ L E ++E V ++ M E + QE E + EQ
Sbjct: 435 -GAEEMVEMLTDR----NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 489
Query: 1112 ------IREMEKQFQ--KEALAEYEARMK 1132
+RE +K+ + +E +A+Y+ +K
Sbjct: 490 DMAGARVREAQKRVEAAQETVADYQQTIK 518
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 57.0 bits (136), Expect = 1e-07
Identities = 66/252 (26%), Positives = 112/252 (44%), Gaps = 29/252 (11%)
Query: 949 PGKGSRKKR---SLPREESAGA--APGEGPEGVDGRVRELKDRLELELLRQGEEQYECVL 1003
P +RKK+ S P ++G +PG+ G+ G R LE E QY+ +
Sbjct: 41 PAGANRKKKINGSSPDTATSGGYHSPGDSATGIYGEGRASSTTLE-----DLESQYQELA 95
Query: 1004 KRKEQHVA------EQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQG 1057
+ A E I+ ++ ++E++ E+ +++ + K + E E G
Sbjct: 96 VALDSSSAIISQLTENINSLVRTSKEEKKHEIHLVQKLGRSLFKLKNQTAEPLAPEPPAG 155
Query: 1058 MTKVTTDKMAQERLKREINNSHIQEVVQVIK-QMTENLERHQEKLEEKQAACLEQIREME 1116
+KV + L++E+ + Q +V QM L R QE+ +Q E++RE E
Sbjct: 156 PSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQE---ERLREQE 212
Query: 1117 KQF--QKEALAEYEARMKGLEAEVKESVRACLRTCFPSEA-KDKPERACECPPELCEQDP 1173
++ Q+E L E E R++ E ++E R C E ++ ER CE LCEQ+
Sbjct: 213 ERLREQEERLCEQEERLREQEERLREQEE---RLCEQEERLREHEERLCEQEERLCEQEE 269
Query: 1174 LIAKADAQESRL 1185
+ + QE RL
Sbjct: 270 RLRE---QEERL 278
Score = 48.9 bits (115), Expect = 3e-05
Identities = 68/287 (23%), Positives = 127/287 (44%), Gaps = 22/287 (7%)
Query: 853 SQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEEL-RELKGVVK-------LQRR 904
+Q LAP P+ + E +++ LE + R+L+ V+ L RR
Sbjct: 142 NQTAEPLAPEPPAGPS-----KVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRR 196
Query: 905 HEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREES 964
E+ LRE E R R EE L+ +L E + + ++ L E
Sbjct: 197 QEERLREQEER-LREQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEE 255
Query: 965 AGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREK 1024
E + R+RE ++RL + R E++ L+ +E+ + EQ ++ E E+
Sbjct: 256 RLCEQEERLCEQEERLREQEERLHEQEERLCEQEER--LREQEERLCEQEERLRE-QEER 312
Query: 1025 QAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVV 1084
+ + L+E E ++ K + + LE ++ + + + QERL ++EV
Sbjct: 313 LCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLER--ERLLEEVE 370
Query: 1085 QVIKQMTENLERHQEKLEEKQAAC-LEQIREMEKQFQKEALAEYEAR 1130
++++Q E L + E+L +++ LE++RE+E+ + A YE R
Sbjct: 371 ELLEQ--ERLRQQDERLWQQETLQELERLRELERMLELGWEALYEQR 415
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 56.6 bits (135), Expect = 1e-07
Identities = 47/157 (29%), Positives = 83/157 (52%), Gaps = 11/157 (7%)
Query: 988 ELELLRQG-EEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKK 1046
E+E LR+ E++ E +LK KE I +M E EK + L+ S ++ +K +
Sbjct: 641 EMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKAR 700
Query: 1047 LETKRLERIQGMTKVTTDKMAQERLKR--EINNSHIQEVVQVIKQMTENLERHQEKLEEK 1104
+LE + K TDKM QE + E N H Q+V +IK+ +++R ++ L+++
Sbjct: 701 ---HKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQ 757
Query: 1105 QAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKES 1141
+ Q+ + K+ K L E++A ++ LEA++K S
Sbjct: 758 ----INQLELLLKERDKH-LKEHQAHVENLEADIKRS 789
Score = 48.1 bits (113), Expect = 5e-05
Identities = 78/343 (22%), Positives = 144/343 (41%), Gaps = 60/343 (17%)
Query: 811 DLTVALANPIKFFSAHDTKSVKLKEAMGGLPE-----KPFPLASPVASQVNGALAPTSNG 865
+ +L ++ S T+ LK+ + P KP P P A P S+G
Sbjct: 209 EFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDG 268
Query: 866 SPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQ 925
P G + + E + R E L LK + + H+++ L E+L +
Sbjct: 269 EPVVEDGTSVKTL-ETLQQRVKRQENL--LKRCKETIQSHKEQCTLLTSEKEALQEQLDE 325
Query: 926 RGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKD 985
R L EL K+ + K + + + A + L +
Sbjct: 326 R----LQELE----------KIKDLHMAEKTKLITQLRDA---------------KNLIE 356
Query: 986 RLELE---LLRQGEEQYECVLKRKEQHVAEQISKMM-------ELAREKQAAELKALKE- 1034
+LE + ++ + + Q L+ KE+ +A+ S++ EL +K+ +E A +E
Sbjct: 357 QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEEL 416
Query: 1035 ----TSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHI-QEVVQVIKQ 1089
++ T+E ++KL+ + E+I+ + K + + ER+ + S + QEVV V+K+
Sbjct: 417 EKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE----ERISLQQELSRVKQEVVDVMKK 472
Query: 1090 MTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMK 1132
+E +KL EK+ A EQ E+ K+ Q E++ +MK
Sbjct: 473 SSEEQIAKLQKLHEKELARKEQ--ELTKKLQTRE-REFQEQMK 512
Score = 44.7 bits (104), Expect = 5e-04
Identities = 45/207 (21%), Positives = 94/207 (45%), Gaps = 26/207 (12%)
Query: 979 RVRELKDRL-----ELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREK----QAAEL 1029
R+ EL+D + E+E L + + Y + + + +++ EL EK + AE
Sbjct: 1526 RIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEE 1585
Query: 1030 KALKETSENDTKEMKKKLETKRLE----RIQGMTKVTTDKMAQERLK-------REINNS 1078
K L T EN MK +LETK+ E + +K K ++RL+ E+
Sbjct: 1586 KIL--TLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRK 1643
Query: 1079 HIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEV 1138
Q++ + KQ+ +E +E+ ++ + L ++ ++ ++E + E ++K +E+
Sbjct: 1644 AEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE-VHILEEKLKSVESSQ 1702
Query: 1139 KESV---RACLRTCFPSEAKDKPERAC 1162
E++ R+ +E ++ + C
Sbjct: 1703 SETLIVPRSAKNVAAYTEQEEADSQGC 1729
Score = 43.9 bits (102), Expect = 0.001
Identities = 55/270 (20%), Positives = 112/270 (41%), Gaps = 58/270 (21%)
Query: 876 EAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELG 935
E ++ E EE+ +L+ +K +ELRE + + R E L++ +
Sbjct: 368 ETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQ--- 424
Query: 936 PPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQG 995
+ E + +L+ E+
Sbjct: 425 -------------------------------------------KTEEARRKLKAEM---- 437
Query: 996 EEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERI 1055
+EQ + + K E+ E+IS EL+R KQ + +K++SE +++K E + +
Sbjct: 438 DEQIKTIEKTSEE---ERISLQQELSRVKQEV-VDVMKKSSEEQIAKLQKLHEKELARKE 493
Query: 1056 QGMTK--VTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIR 1113
Q +TK T ++ QE++K + S E +++ ++ + E+LE ++ A L +
Sbjct: 494 QELTKKLQTREREFQEQMKVALEKSQ-SEYLKISQEKEQQESLALEELELQKKAILTESE 552
Query: 1114 EMEKQFQKEALAEYEARMKGLEAEVKESVR 1143
+ Q+EA Y R+ LE+ +++S++
Sbjct: 553 NKLRDLQQEA-ETYRTRILELESSLEKSLQ 581
Score = 43.9 bits (102), Expect = 0.001
Identities = 50/188 (26%), Positives = 86/188 (45%), Gaps = 24/188 (12%)
Query: 981 RELKDRL---ELELLRQGEEQ---YECVLKRKEQHVAEQISKMMELAREKQA--AELKAL 1032
REL D + E +L +Q EE +E L+ KEQ VAE K++ EK+ E+ L
Sbjct: 1038 RELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWL 1097
Query: 1033 KE------TSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREIN-----NSHIQ 1081
KE T+ N+ +E K+ Q TK+ K E+L+ ++N N+ +Q
Sbjct: 1098 KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKL---KAHLEKLEVDLNKSLKENTFLQ 1154
Query: 1082 EVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQK--EALAEYEARMKGLEAEVK 1139
E + +K + E +R +L K E+ + ++ +K ++L + K L E+
Sbjct: 1155 EQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELA 1214
Query: 1140 ESVRACLR 1147
+ C +
Sbjct: 1215 IQLDICCK 1222
Score = 41.6 bits (96), Expect = 0.005
Identities = 38/176 (21%), Positives = 85/176 (48%), Gaps = 25/176 (14%)
Query: 989 LELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLE 1048
LE L+Q ++ E +LKR ++ + + L EK+A L+E + +E++K +
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEA-----LQEQLDERLQELEKIKD 335
Query: 1049 TKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAAC 1108
E+ + +T++ K E+L+++ + + +QM E LE +E++ + ++
Sbjct: 336 LHMAEKTKLITQLRDAKNLIEQLEQDKG----MVIAETKRQMHETLEMKEEEIAQLRSRI 391
Query: 1109 L------EQIREMEKQFQKEALAEYEARM----------KGLEAEVKESVRACLRT 1148
E++RE +++ ++ A E E + + L+AE+ E ++ +T
Sbjct: 392 KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKT 447
Score = 41.2 bits (95), Expect = 0.006
Identities = 38/163 (23%), Positives = 80/163 (49%), Gaps = 19/163 (11%)
Query: 988 ELELLRQGEEQYECVLKRK-EQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKK 1046
+L +LR+ +Q +LK++ +Q E+I + E K + LK L + +++
Sbjct: 1952 DLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011
Query: 1047 LETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTE-------NLERHQE 1099
LE MT T AQE ++ E+ SH +E Q++K++ E +R++E
Sbjct: 2012 LE---------MTIKETINKAQE-VEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE 2061
Query: 1100 KLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESV 1142
L+ ++ ++R+++ Q + E +Y+ +++ E ++V
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLE-ELQKKYQQKLEQEENPGNDNV 2103
Score = 40.8 bits (94), Expect = 0.008
Identities = 50/260 (19%), Positives = 115/260 (44%), Gaps = 29/260 (11%)
Query: 875 EEAMKEAAEPRTASLEELRELKGVV--------KLQRRHEKELRELERRGARRWEELLQR 926
EE ++ + A+ EEL + KL+ +++++ +E+ L Q
Sbjct: 399 EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQE 458
Query: 927 GAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDR 986
+ E+ V K + K + L +E A E + + R RE +++
Sbjct: 459 LSRVKQEV-------VDVMKKSSEEQIAKLQKLHEKELARKEQ-ELTKKLQTREREFQEQ 510
Query: 987 LELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKK 1046
+++ L + + +Y + + KEQ + LA E+ + KA+ SEN ++++++
Sbjct: 511 MKVAL-EKSQSEYLKISQEKEQQES--------LALEELELQKKAILTESENKLRDLQQE 561
Query: 1047 LETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLE---- 1102
ET R ++ + + + +++ E + K++T +E+H+ +LE
Sbjct: 562 AETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKH 621
Query: 1103 EKQAACLEQIREMEKQFQKE 1122
++ A E+++ +++Q+Q E
Sbjct: 622 QQDALWTEKLQVLKQQYQTE 641
Score = 40.0 bits (92), Expect = 0.013
Identities = 44/182 (24%), Positives = 87/182 (47%), Gaps = 16/182 (8%)
Query: 977 DGRVRELKDRLELELLRQ--GEEQYECVLKRKEQHVAEQISKMMELARE--KQAAELKAL 1032
D R+ + + ELE+L++ +E+ E + + +E + S + +L RE Q A+ +
Sbjct: 1952 DLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQE 2011
Query: 1033 KETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQ--ERLKR------EINNSHIQEVV 1084
E + +T +++E + LE Q T K+A+ + LKR EI ++ +E+
Sbjct: 2012 LEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMT 2071
Query: 1085 QVIKQMTENLE----RHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
++ + LE ++Q+KLE+++ + + ME Q Q + K E E +E
Sbjct: 2072 AKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 1141 SV 1142
+
Sbjct: 2132 QI 2133
Score = 39.7 bits (91), Expect = 0.017
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 10/149 (6%)
Query: 996 EEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKK---LETK-- 1050
E Q + LK KE + ++ +++ ++Q LK E+D +M+KK LET+
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELK 1521
Query: 1051 -RLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQ---A 1106
+ RI + T K + E+ ++ Q+ K++ + L+ QE EEK
Sbjct: 1522 SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVK 1581
Query: 1107 ACLEQIREMEKQFQKEALAEYEARMKGLE 1135
E+I +E Q AE E + K LE
Sbjct: 1582 EAEEKILTLENQVY-SMKAELETKKKELE 1609
Score = 38.9 bits (89), Expect = 0.029
Identities = 43/198 (21%), Positives = 93/198 (46%), Gaps = 34/198 (17%)
Query: 974 EGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQIS--------KMMELAREKQ 1025
E V + +E+++ L+ +LL Q E LK++ ++ A ++S KM+E+A+
Sbjct: 957 EKVKQKAKEMQETLKKKLLDQ-----EAKLKKELENTALELSQKEKQFNAKMLEMAQANS 1011
Query: 1026 AAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLK-REINNSHIQEVV 1084
A A+ N ++++ E R E + + + K+ Q+ + +EI+ +QE
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRE-LNDVISIWEKKLNQQAEELQEIHEIQLQEKE 1070
Query: 1085 QVIKQMTENL-----ERHQEKLE--------EKQAACLEQIREM--EKQFQKEALAEYEA 1129
Q + ++ + + E+ + E KQ L +++E +K +LA+ E
Sbjct: 1071 QEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDET 1130
Query: 1130 RMKG----LEAEVKESVR 1143
++K LE ++ +S++
Sbjct: 1131 KLKAHLEKLEVDLNKSLK 1148
Score = 36.2 bits (82), Expect = 0.19
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 11/158 (6%)
Query: 987 LELELLRQGEEQYE-CVLKRKEQH---VAEQISKMMELAREKQAAELKALKETSENDTKE 1042
L ++L Q ++ + C++++KE H + E SK +L +Q E E +T+E
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906
Query: 1043 MKKK--LETKRLERIQGMTKVTTDKMA-QERLKREINNSHIQEVVQVIKQMTENLERHQE 1099
K ++ K L ++ K+A ER K+++ +E+V++ K + + HQ+
Sbjct: 1907 KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG----KEIVRLQKDLRMLRKEHQQ 1962
Query: 1100 KLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAE 1137
+LE + ++ E KQ Q++ ++ + +K L E
Sbjct: 1963 ELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMRE 2000
Score = 32.0 bits (71), Expect = 3.6
Identities = 37/162 (22%), Positives = 70/162 (43%), Gaps = 26/162 (16%)
Query: 987 LELELLRQGEEQYECVLKRKEQHVAEQISKMMELARE----------------------K 1024
++ +LL Q EE+ E K E H++E +K+ E RE +
Sbjct: 1651 IKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 1025 QAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQE--RLKREINNSHIQE 1082
A + A E E D++ +K +++ +Q +K+ Q + K E +SH +
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQ-RNLTEKEKLLQRVGQEKEETVSSHFEM 1769
Query: 1083 VVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEAL 1124
Q +++ + LE + K E Q+ E+E++ +K +L
Sbjct: 1770 RCQYQERLIK-LEHAEAKQHEDQSMIGHLQEELEEKNKKYSL 1810
Score = 31.6 bits (70), Expect = 4.7
Identities = 35/169 (20%), Positives = 72/169 (42%), Gaps = 41/169 (24%)
Query: 1004 KRKEQHVAEQISKMMELARE-----KQAAELKALKET----------SENDTKEMKKKLE 1048
K E+ +A+ K+++L E KQ AE++A K+ D + +K
Sbjct: 815 KAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQN 874
Query: 1049 TKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAAC 1108
++ ++++ +T+V K+ ++E + E +I QM E ++ E L +K +A
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Query: 1109 LEQI-------------------------REMEKQFQKEALAEYEARMK 1132
+ I +EM++ +K+ L + EA++K
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK-LLDQEAKLK 982
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 55.8 bits (133), Expect = 2e-07
Identities = 45/179 (25%), Positives = 92/179 (51%), Gaps = 10/179 (5%)
Query: 968 APGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAA 1027
+P + EG+ +VR+L+++LE L++ E++ + K + EQ+ + +E+QA
Sbjct: 78 SPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 137
Query: 1028 ELKALKETSE--NDTKEMKKKLETKRLERIQGMTKVTTDK-MAQERLKREINNSHIQEVV 1084
+ LKE + + E K++ + + + T DK MA+ER E ++ +
Sbjct: 138 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER--AESLQQEVEALK 195
Query: 1085 QVIKQMTENLERHQEKLEEK---QAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
+ + ++T +LE + ++EEK AA Q++++E+ Q L + RM+ L + K+
Sbjct: 196 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE--QNARLKDALVRMRDLSSSEKQ 252
Score = 37.4 bits (85), Expect = 0.085
Identities = 61/269 (22%), Positives = 113/269 (42%), Gaps = 38/269 (14%)
Query: 873 AREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLA 932
AR+EA KEA E + +EE+ + + E+ L++ A E LQ+ L
Sbjct: 145 ARKEA-KEALEAKERYMEEMADTADAI--------EMATLDKEMAEERAESLQQEVEALK 195
Query: 933 ELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELL 992
E + K + + S GAA + ++ + LKD L
Sbjct: 196 ERVDELTTDLEILKA----------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 245
Query: 993 RQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRL 1052
E+ E V K Q + E+ ++ +E+ R+ Q L+ +E+ E+K++++
Sbjct: 246 LSSSEKQEHV---KLQKLMEKKNQELEVVRQ-QRERLQEELSQAESTIDELKEQVDAAL- 300
Query: 1053 ERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQ- 1111
+ M ++ TD+ L E ++E V ++ M E + QE E + EQ
Sbjct: 301 -GAEEMVEMLTDR----NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 355
Query: 1112 ------IREMEKQFQ--KEALAEYEARMK 1132
+RE +K+ + +E +A+Y+ +K
Sbjct: 356 DMAGARVREAQKRVEAAQETVADYQQTIK 384
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 55.8 bits (133), Expect = 2e-07
Identities = 45/179 (25%), Positives = 92/179 (51%), Gaps = 10/179 (5%)
Query: 968 APGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAA 1027
+P + EG+ +VR+L+++LE L++ E++ + K + EQ+ + +E+QA
Sbjct: 192 SPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQAD 251
Query: 1028 ELKALKETSE--NDTKEMKKKLETKRLERIQGMTKVTTDK-MAQERLKREINNSHIQEVV 1084
+ LKE + + E K++ + + + T DK MA+ER E ++ +
Sbjct: 252 LQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEER--AESLQQEVEALK 309
Query: 1085 QVIKQMTENLERHQEKLEEK---QAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE 1140
+ + ++T +LE + ++EEK AA Q++++E+ Q L + RM+ L + K+
Sbjct: 310 ERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEE--QNARLKDALVRMRDLSSSEKQ 366
Score = 37.4 bits (85), Expect = 0.085
Identities = 61/269 (22%), Positives = 113/269 (42%), Gaps = 38/269 (14%)
Query: 873 AREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLA 932
AR+EA KEA E + +EE+ + + E+ L++ A E LQ+ L
Sbjct: 259 ARKEA-KEALEAKERYMEEMADTADAI--------EMATLDKEMAEERAESLQQEVEALK 309
Query: 933 ELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELL 992
E + K + + S GAA + ++ + LKD L
Sbjct: 310 ERVDELTTDLEILKA----------EIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRD 359
Query: 993 RQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRL 1052
E+ E V K Q + E+ ++ +E+ R+ Q L+ +E+ E+K++++
Sbjct: 360 LSSSEKQEHV---KLQKLMEKKNQELEVVRQ-QRERLQEELSQAESTIDELKEQVDAAL- 414
Query: 1053 ERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQ- 1111
+ M ++ TD+ L E ++E V ++ M E + QE E + EQ
Sbjct: 415 -GAEEMVEMLTDR----NLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQL 469
Query: 1112 ------IREMEKQFQ--KEALAEYEARMK 1132
+RE +K+ + +E +A+Y+ +K
Sbjct: 470 DMAGARVREAQKRVEAAQETVADYQQTIK 498
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,615,735
Number of Sequences: 37866
Number of extensions: 2419252
Number of successful extensions: 27902
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 290
Number of HSP's successfully gapped in prelim test: 912
Number of HSP's that attempted gapping in prelim test: 17405
Number of HSP's gapped (non-prelim): 7370
length of query: 1185
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1072
effective length of database: 13,968,660
effective search space: 14974403520
effective search space used: 14974403520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.