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Search of human proteins with 94721308
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
(570 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens] 1143 0.0
gi|117500790 FERM domain containing 3 [Homo sapiens] 583 e-166
gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform ... 256 4e-68
gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo s... 256 4e-68
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 255 7e-68
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 255 7e-68
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 253 3e-67
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 249 4e-66
gi|207113195 erythrocyte membrane protein band 4.1-like 2 isofor... 249 4e-66
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 248 1e-65
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 245 7e-65
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 245 7e-65
gi|110624794 erythrocyte membrane protein band 4.1 like 4B isofo... 227 2e-59
gi|110624790 erythrocyte membrane protein band 4.1 like 4B isofo... 227 2e-59
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 223 4e-58
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform... 216 4e-56
gi|34916000 FERM domain containing 7 [Homo sapiens] 208 9e-54
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 196 6e-50
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa... 191 2e-48
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 178 1e-44
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 178 1e-44
gi|150418005 protein tyrosine phosphatase, non-receptor type 21 ... 127 4e-29
gi|34328899 protein tyrosine phosphatase, non-receptor type 14 [... 124 2e-28
gi|161702986 ezrin [Homo sapiens] 119 6e-27
gi|21614499 ezrin [Homo sapiens] 119 6e-27
gi|4506467 radixin [Homo sapiens] 119 6e-27
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 119 1e-26
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 119 1e-26
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 119 1e-26
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 119 1e-26
>gi|94721308 FERM domain containing 5 isoform 2 [Homo sapiens]
Length = 570
Score = 1143 bits (2957), Expect = 0.0
Identities = 570/570 (100%), Positives = 570/570 (100%)
Query: 1 MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGI 60
MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGI
Sbjct: 1 MLSRLMSGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGI 60
Query: 61 RFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRD 120
RFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRD
Sbjct: 61 RFVDPDKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRD 120
Query: 121 LYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHK 180
LYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHK
Sbjct: 121 LYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHK 180
Query: 181 TELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHF 240
TELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHF
Sbjct: 181 TELSGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHF 240
Query: 241 IKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSS 300
IKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSS
Sbjct: 241 IKWNEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSS 300
Query: 301 QVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPR 360
QVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPR
Sbjct: 301 QVRTVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPR 360
Query: 361 LSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIA 420
LSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIA
Sbjct: 361 LSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSNERVAVIA 420
Query: 421 DEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELR 480
DEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELR
Sbjct: 421 DEAYSPADSVLPTPVAEHSLELMLLSRQINGATCSIEEEKESEASTPTATEVEALGGELR 480
Query: 481 ALCQGHSGPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPE 540
ALCQGHSGPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPE
Sbjct: 481 ALCQGHSGPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFRDIRQTPE 540
Query: 541 FEQFHYQYFCPLRRWFACKIRSVVSLLIDT 570
FEQFHYQYFCPLRRWFACKIRSVVSLLIDT
Sbjct: 541 FEQFHYQYFCPLRRWFACKIRSVVSLLIDT 570
>gi|117500790 FERM domain containing 3 [Homo sapiens]
Length = 597
Score = 583 bits (1503), Expect = e-166
Identities = 297/574 (51%), Positives = 393/574 (68%), Gaps = 14/574 (2%)
Query: 7 SGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPD 66
S S +SL +E CT+RLLDDSE +C IQR+ KGQ+L D +C++ +LLEKDYFGIR+VDP+
Sbjct: 22 SSSVKSLSQEMRCTIRLLDDSEISCHIQRETKGQFLIDHICNYYSLLEKDYFGIRYVDPE 81
Query: 67 KQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRL 126
KQRHWLE KS+ KQ+++ PP+TMCFRVKFYP +P +KEE+TRYL++LQIKRD++HGRL
Sbjct: 82 KQRHWLEPNKSIFKQMKTHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRL 141
Query: 127 LCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQ 186
LC SDAA L A I+QAE+GDYD +HPE Y S+F+ FPK S+KLERKI EIHK EL GQ
Sbjct: 142 LCSFSDAAYLGACIVQAELGDYDPDEHPENYISEFEIFPKQSQKLERKIVEIHKNELRGQ 201
Query: 187 TPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEV 246
+P +E N L KA TLETYGVDPHPCKD +G FL FT GFVV QGNKR+H IKW +V
Sbjct: 202 SPPVAEFNLLLKAHTLETYGVDPHPCKDSTGTTTFLGFTAAGFVVFQGNKRIHLIKWPDV 261
Query: 247 TKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVS 306
KLKFEGKTFY+ +QK EKK +L + TP ACKHLWKCG+ENQAFYK KSSQ++TVS
Sbjct: 262 CKLKFEGKTFYVIGTQK-EKKAMLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVS 320
Query: 307 SSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPS------ITHGPR 360
SS +FFKGSRFRYSG+VAKEV+E+S+KI+REPPE+HRA + SRS S I P
Sbjct: 321 SSKIFFKGSRFRYSGKVAKEVVEASSKIQREPPEVHRANITQSRSSHSLNKQLIINMEPL 380
Query: 361 LSSVPRTRRRAVHISIMEGLESLRDSAHSTPVRSTSHGDTFLPHVRSSRTDSN---ERVA 417
+P + + + EG+ ++ S P+ S+S + + + E
Sbjct: 381 QPLLPSPSEQEEELPLGEGVPLPKEENISAPLISSSPVKAAREYEDPPSEEEDKIKEEPL 440
Query: 418 VIADEAYSPADSVLPTPVAEHSLELML---LSRQINGATCSIEEEKESEASTPTATEVEA 474
I++ Y+P+ S+LPTPV + ++++ ++ E+ E++ + E E
Sbjct: 441 TISELVYNPSASLLPTPVDDDEIDMLFDCPSRLELEREDTDSFEDLEADENAFLIAEEEE 500
Query: 475 LGGELRALCQGHS-GPEEEQVNKFVLSVLRLLLVTMGLLFVLLLLLIILTESDLDIAFFR 533
L RAL + +VN V S RLL+V +GLL + LL++L ES +D++F
Sbjct: 501 LKEARRALSWSYDILTGHIRVNPLVKSFSRLLVVGLGLLLFVFPLLLLLLESGIDLSFLC 560
Query: 534 DIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLL 567
+IRQTPEFEQFHY+Y+CPL+ W A K+ ++ +L
Sbjct: 561 EIRQTPEFEQFHYEYYCPLKEWVAGKVHLILYML 594
>gi|4503579 erythrocyte membrane protein band 4.1-like 2 isoform a
[Homo sapiens]
Length = 1005
Score = 256 bits (654), Expect = 4e-68
Identities = 170/514 (33%), Positives = 258/514 (50%), Gaps = 52/514 (10%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLD +EY+C +++ AKGQ LFD +C HLNLLEKDYFG+ F + +Q++WL+ K +
Sbjct: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
+QLR+ P + F VKFYP DP+ L E+ITRY + LQ+++D+ GRL C ALL +
Sbjct: 280 KRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Y LQAE+GDYD +H S+FQF P +++LE K+AE+HKT G +PA ++ FL
Sbjct: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGLSPAQADSQFLEN 397
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ L YGVD H KD G L G ++ + R++ W ++ K+ ++ FY+
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
Query: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
V ++ E+ + + + P A K LWK +E+ FY+L Q L GS+
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTL---GSK 514
Query: 317 FRYSGRVAKEVMESSAKIKREPPEIHRAGM----------------------VPSRSCPS 354
FRYSGR + ++S I R P R P +
Sbjct: 515 FRYSGRTQAQTRQASTLIDRPAPHFERTSSKRVSRSLDGAPIGVMDQSLMKDFPGAAGEI 574
Query: 355 ITHGPRLSSVP-----------RTRRRAVHISIMEGLE-SLRDSAHSTPVRSTSHGDTFL 402
+GP L S+ R+ +A H+ ++EG + SLR + VR H + L
Sbjct: 575 SAYGPGLVSIAVVQDGDGRREVRSPTKAPHLQLIEGKKNSLRVEGDNIYVR---HSNLML 631
Query: 403 PHVRSSRTDSNERVAVIADEAYSPADSV-LPTPVAEHSLELMLLSRQINGATCS----IE 457
+ ++ D + A I++ + +S P P + LS Q G++ +E
Sbjct: 632 EELDKAQEDILKHQASISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSSHETLNIVE 691
Query: 458 EEKESEASTPTATEVEALGGELRALCQGHSGPEE 491
E+K +E E + G + + G SGP E
Sbjct: 692 EKKRAEVGKDERVITEEMNG--KEISPG-SGPGE 722
>gi|40254949 erythrocyte membrane protein band 4.1 like 5 [Homo
sapiens]
Length = 733
Score = 256 bits (654), Expect = 4e-68
Identities = 140/355 (39%), Positives = 210/355 (59%), Gaps = 14/355 (3%)
Query: 7 SGSSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPD 66
+G S+S+ +C V LLD ++ + + + AKGQ LFD + +HL+L+E DYFG+RF+D
Sbjct: 36 AGDSKSI---ITCRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSA 92
Query: 67 KQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRL 126
+ HWL+ TKS+ KQ++ P+ + RVKFY ++P L+EE+TRYL LQ+K+D+ G+L
Sbjct: 93 QVAHWLDGTKSIKKQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKL 152
Query: 127 LCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQ 186
C A LAAY LQAE+GDYD +H S+F+F P +E++E I E K E GQ
Sbjct: 153 DCPFDTAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWK-EYRGQ 211
Query: 187 TPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEV 246
TPA +E N+L KA+ LE YGVD H K GN L TP G +V +G+ ++ W ++
Sbjct: 212 TPAQAETNYLNKAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKI 271
Query: 247 TKLKFEGKTFYLYV----SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQV 302
T+L F+ L V Q +E++ + P+ACKHLWKC +E+ AF++L Q
Sbjct: 272 TRLDFKKNKLTLVVVEDDDQGKEQEHTFVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQ- 330
Query: 303 RTVSSSNLFFKGSRFRYSGRVAKEVMES-----SAKIKREPPEIHRAGMVPSRSC 352
++ S GSRFRYSG+ + ++ S +R P + + + ++C
Sbjct: 331 KSSHRSGFIRLGSRFRYSGKTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKAC 385
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 255 bits (652), Expect = 7e-68
Identities = 133/341 (39%), Positives = 196/341 (57%), Gaps = 11/341 (3%)
Query: 9 SSRSLEREYS---CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65
S + + ++Y C V LLD SEY C +++ +GQ LFDL+C HLNLLEKDYFG+ F D
Sbjct: 24 SPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDA 83
Query: 66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGR 125
D Q++WL+ +K + KQ+RS P + F VKFYP DPA L E+ITRY + LQ++ D+ GR
Sbjct: 84 DSQKNWLDPSKEIKKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGR 142
Query: 126 LLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSG 185
L C ALL +Y +QAE+GDYD+ +H Y S+ +F P + +LE +I E+HKT G
Sbjct: 143 LPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRG 201
Query: 186 QTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNE 245
TP +E++FL A+ L YGVD H KD G L G ++ + R++ W +
Sbjct: 202 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPK 261
Query: 246 VTKLKFEGKTFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVR 303
+ K+ ++ FY+ + + E+ + + + P + K LWK IE+ F++L
Sbjct: 262 ILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP-- 319
Query: 304 TVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRA 344
GS+FRYSGR + ++SA I R P R+
Sbjct: 320 --PPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS 358
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 255 bits (652), Expect = 7e-68
Identities = 133/341 (39%), Positives = 196/341 (57%), Gaps = 11/341 (3%)
Query: 9 SSRSLEREYS---CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDP 65
S + + ++Y C V LLD SEY C +++ +GQ LFDL+C HLNLLEKDYFG+ F D
Sbjct: 86 SPQKIAKKYKSAICRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDA 145
Query: 66 DKQRHWLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGR 125
D Q++WL+ +K + KQ+RS P + F VKFYP DPA L E+ITRY + LQ++ D+ GR
Sbjct: 146 DSQKNWLDPSKEIKKQIRSSP-WNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGR 204
Query: 126 LLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSG 185
L C ALL +Y +QAE+GDYD+ +H Y S+ +F P + +LE +I E+HKT G
Sbjct: 205 LPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRFAPNQTRELEERIMELHKT-YRG 263
Query: 186 QTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNE 245
TP +E++FL A+ L YGVD H KD G L G ++ + R++ W +
Sbjct: 264 MTPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPK 323
Query: 246 VTKLKFEGKTFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVR 303
+ K+ ++ FY+ + + E+ + + + P + K LWK IE+ F++L
Sbjct: 324 ILKISYKRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEP-- 381
Query: 304 TVSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRA 344
GS+FRYSGR + ++SA I R P R+
Sbjct: 382 --PPKGFLVMGSKFRYSGRTQAQTRQASALIDRPAPFFERS 420
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 253 bits (647), Expect = 3e-67
Identities = 140/349 (40%), Positives = 207/349 (59%), Gaps = 23/349 (6%)
Query: 12 SLEREYSCTVRLLDDSEYTCT-----IQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPD 66
++ E+ C V LLD+S+ T T I++ KG + D + HH+NL+E DYFG+R+ D
Sbjct: 6 AVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRS 65
Query: 67 KQRHWLEFTKSVVKQ---LRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYH 123
Q +WL+ K++ + + + PP+T+ F +KFY DP LKEEITRY FLQ+K+D+
Sbjct: 66 HQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQ 125
Query: 124 GRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTEL 183
GRL C + AA L AY +Q+E+GDYD KH GY S+++F P E+LE I IHKT L
Sbjct: 126 GRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKT-L 184
Query: 184 SGQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKW 243
GQ P+ +ELN+LR A++LE YGVD HP + + FL TP G VV + K+V W
Sbjct: 185 MGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFW 244
Query: 244 NEVTKLKFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVR 303
+TK+ F+ F L V K+ + + A + ACKHLWKC +E+ F+++ ++
Sbjct: 245 PRITKVHFKETQFELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPEN---- 300
Query: 304 TVSSSNLFFKGSRF-------RYSGRVAKEV-MESSAKIKREPPEIHRA 344
S++L K S+F RYSGR A ++ + S ++ R + R+
Sbjct: 301 --ESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRS 347
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 249 bits (637), Expect = 4e-66
Identities = 132/327 (40%), Positives = 192/327 (58%), Gaps = 7/327 (2%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLD +EY+C +++ AKGQ LFD +C HLNLLEKDYFG+ F + +Q++WL+ K +
Sbjct: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
+QLR+ P + F VKFYP DP+ L E+ITRY + LQ+++D+ GRL C ALL +
Sbjct: 280 KRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Y LQAE+GDYD +H S+FQF P +++LE K+AE+HKT G +PA ++ FL
Sbjct: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGLSPAQADSQFLEN 397
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ L YGVD H KD G L G ++ + R++ W ++ K+ ++ FY+
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
Query: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
V ++ E+ + + + P A K LWK +E+ FY+L Q L GS+
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTL---GSK 514
Query: 317 FRYSGRVAKEVMESSAKIKREPPEIHR 343
FRYSGR + ++S I R P R
Sbjct: 515 FRYSGRTQAQTRQASTLIDRPAPHFER 541
>gi|207113195 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 249 bits (637), Expect = 4e-66
Identities = 132/327 (40%), Positives = 192/327 (58%), Gaps = 7/327 (2%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLD +EY+C +++ AKGQ LFD +C HLNLLEKDYFG+ F + +Q++WL+ K +
Sbjct: 220 CKVTLLDGTEYSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEI 279
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
+QLR+ P + F VKFYP DP+ L E+ITRY + LQ+++D+ GRL C ALL +
Sbjct: 280 KRQLRNLP-WLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGS 338
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Y LQAE+GDYD +H S+FQF P +++LE K+AE+HKT G +PA ++ FL
Sbjct: 339 YTLQAELGDYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTH-RGLSPAQADSQFLEN 397
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ L YGVD H KD G L G ++ + R++ W ++ K+ ++ FY+
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNFYI 457
Query: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
V ++ E+ + + + P A K LWK +E+ FY+L Q L GS+
Sbjct: 458 KVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAKFLTL---GSK 514
Query: 317 FRYSGRVAKEVMESSAKIKREPPEIHR 343
FRYSGR + ++S I R P R
Sbjct: 515 FRYSGRTQAQTRQASTLIDRPAPHFER 541
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 248 bits (633), Expect = 1e-65
Identities = 129/332 (38%), Positives = 192/332 (57%), Gaps = 8/332 (2%)
Query: 15 REYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEF 74
+ C V LLD SEYTC +++ ++GQ LFD +C HLNLLEKDYFG+ + D + Q++WL+
Sbjct: 108 KSMQCKVILLDGSEYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDP 167
Query: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
K + KQ+RS + F VKFYP DPA L E+ITRY + LQ++ D+ GRL C A
Sbjct: 168 AKEIKKQVRSGA-WHFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLA 226
Query: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
LL +Y +Q+E+GDYD + Y S+F+F P H+++LE K+ E+HK+ G TPA +E++
Sbjct: 227 LLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKELEDKVIELHKSH-RGMTPAEAEMH 285
Query: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
FL A+ L YGVD H KD G L G ++ + R++ W +V K+ ++
Sbjct: 286 FLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRN 345
Query: 255 TFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
FY+ + + E+ + + + P A K LWK +E+ F++L +
Sbjct: 346 NFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFFRL----LLPEAPPKKFLT 401
Query: 313 KGSRFRYSGRVAKEVMESSAKIKREPPEIHRA 344
GS+FRYSGR + +SA I R P R+
Sbjct: 402 LGSKFRYSGRTQAQTRRASALIDRPAPYFERS 433
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 245 bits (626), Expect = 7e-65
Identities = 133/363 (36%), Positives = 202/363 (55%), Gaps = 9/363 (2%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLDD+ Y C +++ AKGQ L +C HLNLLE+DYFG+ D + WL+ K +
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
KQ+R P + F VKFYP DPA L E+ITRY + LQ+++D+ GRL C + ALL +
Sbjct: 63 KKQVRGVP-WNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Y +Q+E+GDYD H Y S F+ P +++LE K+ E+HK+ S TPA ++L FL
Sbjct: 122 YTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRS-MTPAQADLEFLEN 180
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ L YGVD H KD+ G L G +V + R++ W +V K+ ++ +F++
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
+ ++E+ + + + P+ A K LWK +E+ F++L + T+ S GS+
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALGSK 297
Query: 317 FRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISI 376
FRYSGR + ++SA I R P R R+ S+ + S R+ R +I
Sbjct: 298 FRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAPAI 355
Query: 377 MEG 379
+G
Sbjct: 356 TQG 358
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 245 bits (626), Expect = 7e-65
Identities = 133/363 (36%), Positives = 202/363 (55%), Gaps = 9/363 (2%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLDD+ Y C +++ AKGQ L +C HLNLLE+DYFG+ D + WL+ K +
Sbjct: 3 CKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEI 62
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
KQ+R P + F VKFYP DPA L E+ITRY + LQ+++D+ GRL C + ALL +
Sbjct: 63 KKQVRGVP-WNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGS 121
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
Y +Q+E+GDYD H Y S F+ P +++LE K+ E+HK+ S TPA ++L FL
Sbjct: 122 YTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRS-MTPAQADLEFLEN 180
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ L YGVD H KD+ G L G +V + R++ W +V K+ ++ +F++
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFI 240
Query: 259 YV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSR 316
+ ++E+ + + + P+ A K LWK +E+ F++L + T+ S GS+
Sbjct: 241 KIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLALGSK 297
Query: 317 FRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHISI 376
FRYSGR + ++SA I R P R R+ S+ + S R+ R +I
Sbjct: 298 FRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTSAPAI 355
Query: 377 MEG 379
+G
Sbjct: 356 TQG 358
>gi|110624794 erythrocyte membrane protein band 4.1 like 4B isoform
1 [Homo sapiens]
Length = 518
Score = 227 bits (579), Expect = 2e-59
Identities = 126/351 (35%), Positives = 197/351 (56%), Gaps = 11/351 (3%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLD +E + + + AKGQ LFD + +HL+L+E DYFG++F+D + HWL+ K +
Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
KQ++ P + + FRVK+Y ++P L+EE TRYL LQ++ D+ G+L C A LAA
Sbjct: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
LQAE+G+ + +H S+F+F P +E +E I + K E G++PA +EL++L K
Sbjct: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKSPAQAELSYLNK 265
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ LE YGVD H + G L TP G ++ +G ++ W ++TK+ F+ L
Sbjct: 266 AKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTL 325
Query: 259 YV----SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKG 314
V Q E++ + + CKHLWKC +E+ AF++L ++ + S+ G
Sbjct: 326 VVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS-NRSDFIRLG 384
Query: 315 SRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVP 365
SRFR+SGR + S +++R + PS+ PS H +S P
Sbjct: 385 SRFRFSGRTEYQATHGS-RLRRTSTFERK----PSKRYPSRRHSTFKASNP 430
>gi|110624790 erythrocyte membrane protein band 4.1 like 4B isoform
2 [Homo sapiens]
Length = 900
Score = 227 bits (579), Expect = 2e-59
Identities = 126/351 (35%), Positives = 197/351 (56%), Gaps = 11/351 (3%)
Query: 19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV 78
C V LLD +E + + + AKGQ LFD + +HL+L+E DYFG++F+D + HWL+ K +
Sbjct: 87 CRVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDYFGLQFLDSAQVAHWLDHAKPI 146
Query: 79 VKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAA 138
KQ++ P + + FRVK+Y ++P L+EE TRYL LQ++ D+ G+L C A LAA
Sbjct: 147 KKQMKIGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQLRHDILSGKLKCPYETAVELAA 206
Query: 139 YILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRK 198
LQAE+G+ + +H S+F+F P +E +E I + K E G++PA +EL++L K
Sbjct: 207 LCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWK-ECRGKSPAQAELSYLNK 265
Query: 199 AQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYL 258
A+ LE YGVD H + G L TP G ++ +G ++ W ++TK+ F+ L
Sbjct: 266 AKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKITKMDFKKSKLTL 325
Query: 259 YV----SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKG 314
V Q E++ + + CKHLWKC +E+ AF++L ++ + S+ G
Sbjct: 326 VVVEDDDQGREQEHTFVFRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS-NRSDFIRLG 384
Query: 315 SRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVP 365
SRFR+SGR + S +++R + PS+ PS H +S P
Sbjct: 385 SRFRFSGRTEYQATHGS-RLRRTSTFERK----PSKRYPSRRHSTFKASNP 430
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 223 bits (568), Expect = 4e-58
Identities = 111/310 (35%), Positives = 187/310 (60%), Gaps = 4/310 (1%)
Query: 16 EYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQR-HWLEF 74
E C + LLD++ + + +GQ L D++ HL+L E+DYFG++ D WL+
Sbjct: 28 EVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDP 87
Query: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
K + KQL+ P+++ FRVKF+ +DP L+EE TRY FLQIK+D+ GRL C ++ AA
Sbjct: 88 NKPIRKQLKRGSPYSLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAA 147
Query: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
LLA++ +Q+E+GDYD ++ GY S + F P + E++IA++H+ + G +PA +E N
Sbjct: 148 LLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKEIAKLHQQHI-GLSPAEAEFN 206
Query: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
+L A+TLE YGV+ H +D S N + G ++ + R++ W ++ K+ F+ K
Sbjct: 207 YLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFPWLKIVKISFKCK 266
Query: 255 TFYLYVSQK--EEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
F++ + ++ E ++ +L + ACK+LWK +E+ F++L++ + ++ F
Sbjct: 267 QFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPLPPQKNFFAHYFT 326
Query: 313 KGSRFRYSGR 322
GS+FRY GR
Sbjct: 327 LGSKFRYCGR 336
>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
[Homo sapiens]
Length = 1045
Score = 216 bits (550), Expect = 4e-56
Identities = 131/374 (35%), Positives = 205/374 (54%), Gaps = 20/374 (5%)
Query: 18 SCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKS 77
S +++LDD++ + + A G+ L D +C+HLNL+E DYFG+ F D K WL+ K
Sbjct: 41 SIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKP 100
Query: 78 VVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLA 137
+VKQ+R + F VKF+P D L+EE+TRYL LQ+K+DL GRL C + AALL
Sbjct: 101 IVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLI 160
Query: 138 AYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLR 197
++I+Q+EIGD+D E + +K ++ P+ + LE KI E H + GQTPA S+ L
Sbjct: 161 SHIVQSEIGDFDEALDRE-HLAKNKYIPQ-QDALEDKIVEFHHNHI-GQTPAESDFQLLE 217
Query: 198 KAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFY 257
A+ LE YG+ HP KD G LA G +V QG +++ W +V KL F+ K F
Sbjct: 218 IARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFL 277
Query: 258 LYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGS 315
+ + + L + + + CK WK +E+ AF++L + + + LF +GS
Sbjct: 278 IKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHHAFFRLFEEPKPK--PKPVLFSRGS 335
Query: 316 RFRYSGRVAKEVME-------SSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTR 368
FR+SGR K+V++ + +R+ +IH + S+ P+ + S V
Sbjct: 336 SFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQ--PTELN----SEVLEQS 389
Query: 369 RRAVHISIMEGLES 382
+++ ++ EG ES
Sbjct: 390 QQSTSLTFGEGAES 403
>gi|34916000 FERM domain containing 7 [Homo sapiens]
Length = 714
Score = 208 bits (530), Expect = 9e-54
Identities = 123/339 (36%), Positives = 189/339 (55%), Gaps = 10/339 (2%)
Query: 21 VRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80
V+ LDDS+ + + + G+ LF+L C HLNL EK+YFG+ F WLE K + K
Sbjct: 6 VQFLDDSQKIFVVDQKSSGKALFNLSCSHLNLAEKEYFGLEFCSHSGNNVWLELLKPITK 65
Query: 81 QLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYI 140
Q+++ F VKF+P DP L+EE+TRYL LQIK+DL GRL C + AL+ ++I
Sbjct: 66 QVKNPKEIVFKFMVKFFPVDPGHLREELTRYLFTLQIKKDLALGRLPCSDNCTALMVSHI 125
Query: 141 LQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQ 200
LQ+E+GD+ + + ++ ++ P + + LE KI H+ + G++PA S++ L A+
Sbjct: 126 LQSELGDFHE-ETDRKHLAQTRYLP-NQDCLEGKIMHFHQKHI-GRSPAESDILLLDIAR 182
Query: 201 TLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFY--L 258
L+ YG+ PHP D G LA G +VL+GN +++ W ++ KL F+ K F L
Sbjct: 183 KLDMYGIRPHPASDGEGMQIHLAVAHMGVLVLRGNTKINTFNWAKIRKLSFKRKHFLIKL 242
Query: 259 YVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFR 318
+ + K L + + +ACK WK +E AF++L S + ++ + L KGS FR
Sbjct: 243 HANILVLCKDTLEFTMASRDACKAFWKTCVEYHAFFRL--SEEPKSKPKTLLCSKGSSFR 300
Query: 319 YSGRVAKEVMESSAK--IKREPPE-IHRAGMVPSRSCPS 354
YSGR ++++E K +K P E H R C S
Sbjct: 301 YSGRTQRQLLEYGRKGRLKSLPFERKHYPSQYHERQCRS 339
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 196 bits (497), Expect = 6e-50
Identities = 117/367 (31%), Positives = 181/367 (49%), Gaps = 44/367 (11%)
Query: 15 REYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEF 74
R C V LLDD+ Y C ++ WL+
Sbjct: 208 RNMHCKVSLLDDTVYECVVET-----------------------------------WLDS 232
Query: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
K + KQ+R P + F VKFYP DPA L E+ITRY + LQ+++D+ GRL C + A
Sbjct: 233 AKEIKKQVRGVP-WNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLA 291
Query: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
LL +Y +Q+E+GDYD H Y S F+ P +++LE K+ E+HK+ S TPA ++L
Sbjct: 292 LLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRS-MTPAQADLE 350
Query: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
FL A+ L YGVD H KD+ G L G +V + R++ W +V K+ ++
Sbjct: 351 FLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRS 410
Query: 255 TFYLYV--SQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
+F++ + ++E+ + + + P+ A K LWK +E+ F++L + T+ S
Sbjct: 411 SFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTD---TIPKSKFLA 467
Query: 313 KGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAV 372
GS+FRYSGR + ++SA I R P R R+ S+ + S R+ R
Sbjct: 468 LGSKFRYSGRTQAQTRQASALIDRPAPHFERT--ASKRASRSLDGAAAVDSADRSPRPTS 525
Query: 373 HISIMEG 379
+I +G
Sbjct: 526 APAITQG 532
>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
sapiens]
Length = 1054
Score = 191 bits (484), Expect = 2e-48
Identities = 131/396 (33%), Positives = 196/396 (49%), Gaps = 22/396 (5%)
Query: 11 RSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRH 70
R E+ V+LLD++ I+ GQ L + LNL+E DYFG+ F +
Sbjct: 38 RMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNTQSYWI 97
Query: 71 WLEFTKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKT 130
WLE K +++Q+R + VKF+P DP L+EE TRYL LQ+KRDL RL C
Sbjct: 98 WLEPMKPIIRQIRRPKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCAD 157
Query: 131 SDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPAT 190
+ AALL +++LQ+EIGDYD E + ++ P LE KI E H+ + GQTPA
Sbjct: 158 TTAALLTSHLLQSEIGDYDETLDRE-HLKVNEYLPGQQHCLE-KILEFHQKHV-GQTPAE 214
Query: 191 SELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLK 250
S+ L A+ LE YG+ H D G LA + G +V QG +++ W++V KL
Sbjct: 215 SDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTFNWSKVRKLS 274
Query: 251 FEGKTFY--LYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSS 308
F+ K F L+ + L + + + CK+ WK +E F++L Q + + +
Sbjct: 275 FKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRL--LDQPKPKAKA 332
Query: 309 NLFFKGSRFRYSGRVAKEVME--SSAKIKREPPE-----IHRAGMVPSRSCP----SITH 357
F +GS FRYSGR K++++ + +KR P E H + + P S
Sbjct: 333 VFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTADLPKQSISFPE 392
Query: 358 GPRLSSVPRTRRRAVHIS----IMEGLESLRDSAHS 389
G R + P + +S + GL +DS+ S
Sbjct: 393 GLRTPASPSSANAFYSLSPSTLVPSGLPEFKDSSSS 428
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 178 bits (452), Expect = 1e-44
Identities = 103/318 (32%), Positives = 168/318 (52%), Gaps = 12/318 (3%)
Query: 16 EYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQR-HWLEF 74
E C++ LD T + + GQ L D++ +HL + EK+YFG++ D WLE
Sbjct: 28 EVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEA 87
Query: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
+K++ KQL+ P T+ FRV+F+ DP L++E TR+L FLQ+K D+ GRL C + A
Sbjct: 88 SKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAV 147
Query: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
+LA+Y +Q+ GDY+S H GY S F P +E K+ +H+ + SG + +E
Sbjct: 148 VLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHE-QHSGLKQSEAESC 206
Query: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
++ A+TL+ YGV+ H +D+ + G V + F W + K+ F+ K
Sbjct: 207 YINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRK 266
Query: 255 TFYLYVSQK--EEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEK--------SSQVRT 304
F+++ QK E ++ I+ + +CK+LWK +E+ F++ +K SQ T
Sbjct: 267 KFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWT 326
Query: 305 VSSSNLFFKGSRFRYSGR 322
+ S N + R R+ R
Sbjct: 327 MGSRNTKKRSPRLRHEIR 344
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 178 bits (452), Expect = 1e-44
Identities = 117/370 (31%), Positives = 188/370 (50%), Gaps = 17/370 (4%)
Query: 16 EYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQR-HWLEF 74
E C++ LD T + + GQ L D++ +HL + EK+YFG++ D WLE
Sbjct: 28 EVICSIHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEA 87
Query: 75 TKSVVKQLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAA 134
+K++ KQL+ P T+ FRV+F+ DP L++E TR+L FLQ+K D+ GRL C + A
Sbjct: 88 SKAIRKQLKGGFPCTLHFRVRFFIPDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAV 147
Query: 135 LLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELN 194
+LA+Y +Q+ GDY+S H GY S F P +E K+ +H+ + SG + +E
Sbjct: 148 VLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQNEDFLTKVESLHE-QHSGLKQSEAESC 206
Query: 195 FLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGK 254
++ A+TL+ YGV+ H +D+ + G V + F W + K+ F+ K
Sbjct: 207 YINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVYRKYICTSFYPWVNILKISFKRK 266
Query: 255 TFYLYVSQK--EEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEK--------SSQVRT 304
F+++ QK E ++ I+ + +CK+LWK +E+ F++ +K SQ T
Sbjct: 267 KFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKKLLPQEKNVLSQYWT 326
Query: 305 VSSSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSIT---HGPRL 361
+ S N K +Y +V ++ + A + E +PSRS P IT PRL
Sbjct: 327 MGSRNT-KKSVNNQYCKKVIGGMVWNPAMRRSLSVEHLETKSLPSRS-PPITPNWRSPRL 384
Query: 362 SSVPRTRRRA 371
R R +
Sbjct: 385 RHEIRKPRHS 394
>gi|150418005 protein tyrosine phosphatase, non-receptor type 21
[Homo sapiens]
Length = 1174
Score = 127 bits (318), Expect = 4e-29
Identities = 88/337 (26%), Positives = 165/337 (48%), Gaps = 26/337 (7%)
Query: 21 VRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80
++LL++ T+ ++ GQ + + L L E YF + + + QR W++ K + K
Sbjct: 27 IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKK 86
Query: 81 QLRS---QPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLA 137
QL +P T+ F V FY + L++EITRY +LQ+K+D+ G + C A LA
Sbjct: 87 QLDKYALEP--TVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLA 144
Query: 138 AYILQAEIGDYDSGKHPEGYSSKFQFFP-------KHSEKLERKIAEIHKTELSGQTPAT 190
+QA+ GD+D + + KF FP K E+ +K+A +H+ + G T
Sbjct: 145 GLAVQADFGDFDQ-YESQDFLQKFALFPVGWLQDEKVLEEATQKVALLHQ-KYRGLTAPD 202
Query: 191 SELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFI-KWNEVTKL 249
+E+ ++++ + ++ YG + +P KD G+ + G V N R + +W+++ +
Sbjct: 203 AEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANM 262
Query: 250 KFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSS-QVRTVSSS 308
F L ++ KEE + + E K++W+ + FY+L + + Q +TV+ +
Sbjct: 263 SHNKSFFALELANKEE---TIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLQTQTVTVN 319
Query: 309 NLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAG 345
+ R R S R++ + + + PP++H G
Sbjct: 320 PI-----RRRSSSRMS--LPKPQPYVMPPPPQLHYNG 349
>gi|34328899 protein tyrosine phosphatase, non-receptor type 14
[Homo sapiens]
Length = 1187
Score = 124 bits (311), Expect = 2e-28
Identities = 83/289 (28%), Positives = 139/289 (48%), Gaps = 18/289 (6%)
Query: 21 VRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80
+RLLD + CT+ ++ GQ + + L L E YFG+ F+ +Q W+E K + K
Sbjct: 25 IRLLDSNVIECTLSVESTGQECLEAVAQRLELRETHYFGLWFLSKSQQARWVELEKPLKK 84
Query: 81 QL---RSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLA 137
L ++P + F V FY + + L++E TRY +LQ+K+D+ GRL C LA
Sbjct: 85 HLDKFANEP--LLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLA 142
Query: 138 AYILQAEIGDYDSGKHPEGYSSKFQFFPKH-------SEKLERKIAEIHKTELSGQTPAT 190
+QA+ GDY+ + + ++ FP E+L +K+A+ HK SG PA
Sbjct: 143 GLAVQADFGDYNQ-FDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAH-SGILPAE 200
Query: 191 SELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFG-FVVLQGNKRVHFIKWNEVTKL 249
+EL ++ + + L+ +G + P KD GN L G FV + ++ +WN++ +
Sbjct: 201 AELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNI 260
Query: 250 KFEGKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEK 298
T + + KEE + + E K++ + FYK K
Sbjct: 261 THNKSTILVELINKEETAL---FHTDDIENAKYISRLFATRHKFYKQNK 306
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 119 bits (299), Expect = 6e-27
Identities = 88/334 (26%), Positives = 151/334 (45%), Gaps = 17/334 (5%)
Query: 26 DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV-VKQLRS 84
D+E IQ + G+ LFD + + L E YFG+ +VD WL+ K V +++R
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 85 QPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQA 143
+ P FR KFYP D A L ++IT+ L FLQ+K + + C A LL +Y +QA
Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 144 EIGDYDSGKHPEGYSSKFQFFPKH---SEKLERKIAE----IHKTELSGQTPATSELNFL 196
+ GDY+ H GY S + P+ KL R E + E G + L +L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 197 RKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVH---FIKWNEVTKLKFEG 253
+ AQ LE YG++ K+ G +L G + + + ++ W+E+ + F
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252
Query: 254 KTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFK 313
K F + K+ + ++AP K + + + N Y + T+ + +
Sbjct: 253 KKFVIKPIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPD--TIEVQQMKAQ 308
Query: 314 GSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMV 347
++ ++ ++ +E+ K +RE E + M+
Sbjct: 309 AREEKHQKQLERQQLETEKK-RRETVEREKEQMM 341
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 119 bits (299), Expect = 6e-27
Identities = 88/334 (26%), Positives = 151/334 (45%), Gaps = 17/334 (5%)
Query: 26 DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSV-VKQLRS 84
D+E IQ + G+ LFD + + L E YFG+ +VD WL+ K V +++R
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRK 72
Query: 85 QPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQA 143
+ P FR KFYP D A L ++IT+ L FLQ+K + + C A LL +Y +QA
Sbjct: 73 ENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQA 132
Query: 144 EIGDYDSGKHPEGYSSKFQFFPKH---SEKLERKIAE----IHKTELSGQTPATSELNFL 196
+ GDY+ H GY S + P+ KL R E + E G + L +L
Sbjct: 133 KFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYL 192
Query: 197 RKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVH---FIKWNEVTKLKFEG 253
+ AQ LE YG++ K+ G +L G + + + ++ W+E+ + F
Sbjct: 193 KIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFND 252
Query: 254 KTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFK 313
K F + K+ + ++AP K + + + N Y + T+ + +
Sbjct: 253 KKFVIKPIDKKAPDFV--FYAPRLRINKRILQLCMGNHELYMRRRKPD--TIEVQQMKAQ 308
Query: 314 GSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMV 347
++ ++ ++ +E+ K +RE E + M+
Sbjct: 309 AREEKHQKQLERQQLETEKK-RRETVEREKEQMM 341
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 119 bits (299), Expect = 6e-27
Identities = 87/328 (26%), Positives = 151/328 (46%), Gaps = 19/328 (5%)
Query: 26 DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVKQ-LRS 84
D+E IQ + G+ LFD + + L E +FG+++VD WL+ K V +Q ++
Sbjct: 13 DAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKK 72
Query: 85 QPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQA 143
+ P FR KF+P D + L +EIT+ L FLQ+K + + + C A LLA+Y +QA
Sbjct: 73 ENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQA 132
Query: 144 EIGDYDSGKHPEGYSSKFQFFPKH--------SEKLERKIAEIHKTELSGQTPATSELNF 195
+ GDY+ H GY + + P+ E+ E +I H+ E G S + +
Sbjct: 133 KYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHE-EHRGMLREDSMMEY 191
Query: 196 LRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVH---FIKWNEVTKLKFE 252
L+ AQ LE YGV+ K+ G +L G + + + ++ W+E+ + F
Sbjct: 192 LKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFN 251
Query: 253 GKTFYLYVSQKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFF 312
K F + K+ + ++AP K + + N Y + T+ +
Sbjct: 252 DKKFVIKPIDKKAPDFV--FYAPRLRINKRILALCMGNHELYMRRRKPD--TIEVQQMKA 307
Query: 313 KGSRFRYSGRVAKEVMESSAKIKREPPE 340
+ ++ ++ + +E+ K KRE E
Sbjct: 308 QAREEKHQKQLERAQLENEKK-KREIAE 334
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 119 bits (297), Expect = 1e-26
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 14/264 (5%)
Query: 6 MSGSSRSLEREYSCTVRLLD-DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVD 64
MS SS ++ + TVR++ D+E + KG+ LFDL+C L L E +FG+++
Sbjct: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI 68
Query: 65 PDKQRHWLEFTKSVVKQ-LRSQPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLY 122
D WL+ K V+ + + P T F KFYP + L +EIT++L FLQ+K+ +
Sbjct: 69 KDTVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQIL 127
Query: 123 HGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTE 182
++ C + LLA+Y +QA+ GDYD H G+ ++ + PK L + E+ +
Sbjct: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
Query: 183 LS-------GQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGN 235
++ G+ +E+ +L+ AQ LE YGV+ ++ G L G +
Sbjct: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPE 247
Query: 236 KRVH---FIKWNEVTKLKFEGKTF 256
R+ WNE+ + + K F
Sbjct: 248 NRLTPKISFPWNEIRNISYSDKEF 271
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 119 bits (297), Expect = 1e-26
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 14/264 (5%)
Query: 6 MSGSSRSLEREYSCTVRLLD-DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVD 64
MS SS ++ + TVR++ D+E + KG+ LFDL+C L L E +FG+++
Sbjct: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI 68
Query: 65 PDKQRHWLEFTKSVVKQ-LRSQPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLY 122
D WL+ K V+ + + P T F KFYP + L +EIT++L FLQ+K+ +
Sbjct: 69 KDTVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQIL 127
Query: 123 HGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTE 182
++ C + LLA+Y +QA+ GDYD H G+ ++ + PK L + E+ +
Sbjct: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
Query: 183 LS-------GQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGN 235
++ G+ +E+ +L+ AQ LE YGV+ ++ G L G +
Sbjct: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPE 247
Query: 236 KRVH---FIKWNEVTKLKFEGKTF 256
R+ WNE+ + + K F
Sbjct: 248 NRLTPKISFPWNEIRNISYSDKEF 271
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 119 bits (297), Expect = 1e-26
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 14/264 (5%)
Query: 6 MSGSSRSLEREYSCTVRLLD-DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVD 64
MS SS ++ + TVR++ D+E + KG+ LFDL+C L L E +FG+++
Sbjct: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI 68
Query: 65 PDKQRHWLEFTKSVVKQ-LRSQPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLY 122
D WL+ K V+ + + P T F KFYP + L +EIT++L FLQ+K+ +
Sbjct: 69 KDTVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQIL 127
Query: 123 HGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTE 182
++ C + LLA+Y +QA+ GDYD H G+ ++ + PK L + E+ +
Sbjct: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
Query: 183 LS-------GQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGN 235
++ G+ +E+ +L+ AQ LE YGV+ ++ G L G +
Sbjct: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPE 247
Query: 236 KRVH---FIKWNEVTKLKFEGKTF 256
R+ WNE+ + + K F
Sbjct: 248 NRLTPKISFPWNEIRNISYSDKEF 271
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 119 bits (297), Expect = 1e-26
Identities = 78/264 (29%), Positives = 130/264 (49%), Gaps = 14/264 (5%)
Query: 6 MSGSSRSLEREYSCTVRLLD-DSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVD 64
MS SS ++ + TVR++ D+E + KG+ LFDL+C L L E +FG+++
Sbjct: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTI 68
Query: 65 PDKQRHWLEFTKSVVKQ-LRSQPPFTMCFRVKFYPADPAA-LKEEITRYLVFLQIKRDLY 122
D WL+ K V+ + + P T F KFYP + L +EIT++L FLQ+K+ +
Sbjct: 69 KDTVA-WLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQIL 127
Query: 123 HGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTE 182
++ C + LLA+Y +QA+ GDYD H G+ ++ + PK L + E+ +
Sbjct: 128 DEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEER 187
Query: 183 LS-------GQTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGN 235
++ G+ +E+ +L+ AQ LE YGV+ ++ G L G +
Sbjct: 188 ITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPE 247
Query: 236 KRVH---FIKWNEVTKLKFEGKTF 256
R+ WNE+ + + K F
Sbjct: 248 NRLTPKISFPWNEIRNISYSDKEF 271
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,714,182
Number of Sequences: 37866
Number of extensions: 957356
Number of successful extensions: 2866
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2681
Number of HSP's gapped (non-prelim): 68
length of query: 570
length of database: 18,247,518
effective HSP length: 108
effective length of query: 462
effective length of database: 14,157,990
effective search space: 6540991380
effective search space used: 6540991380
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.