Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 94721248
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94721248 ankyrin repeat and SOCS box-containing protein 1
[Homo sapiens]
(335 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Ho... 693 0.0
gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [H... 188 7e-48
gi|18254474 ankyrin repeat and SOCS box-containing protein 11 is... 99 7e-21
gi|60218887 ankyrin repeat and SOCS box-containing protein 11 is... 99 7e-21
gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Ho... 93 3e-19
gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1 [... 91 1e-18
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 86 4e-17
gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [H... 81 1e-15
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 80 2e-15
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 78 1e-14
gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3... 74 1e-13
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 74 2e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 74 2e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 74 2e-13
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 72 9e-13
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 71 1e-12
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 71 1e-12
gi|70995241 ankyrin repeat domain 10 [Homo sapiens] 70 2e-12
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 70 3e-12
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 70 3e-12
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 70 3e-12
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 70 3e-12
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 70 3e-12
gi|7657265 fem-1 homolog b [Homo sapiens] 69 5e-12
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 69 6e-12
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 69 6e-12
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 69 8e-12
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 68 1e-11
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 68 1e-11
gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens] 67 3e-11
>gi|94721248 ankyrin repeat and SOCS box-containing protein 1 [Homo
sapiens]
Length = 335
Score = 693 bits (1789), Expect = 0.0
Identities = 335/335 (100%), Positives = 335/335 (100%)
Query: 1 MAEGGSPDGRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEE 60
MAEGGSPDGRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEE
Sbjct: 1 MAEGGSPDGRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEE 60
Query: 61 SYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVV 120
SYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVV
Sbjct: 61 SYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVV 120
Query: 121 NGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDV 180
NGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDV
Sbjct: 121 NGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDV 180
Query: 181 QPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVM 240
QPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVM
Sbjct: 181 QPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVM 240
Query: 241 DAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRTLL 300
DAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRTLL
Sbjct: 241 DAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRTLL 300
Query: 301 CLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
CLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE
Sbjct: 301 CLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
>gi|22208955 ankyrin repeat and SOCS box-containing protein 12 [Homo
sapiens]
Length = 309
Score = 188 bits (477), Expect = 7e-48
Identities = 119/302 (39%), Positives = 175/302 (57%), Gaps = 22/302 (7%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
E L+ A Y D TL LL++E Y+ IN +S W +P TPLR+AA+ GH SC+
Sbjct: 26 EKQALNQAVYDNDSYTLDQLLRQERYKRFINSRSGW---GVPGTPLRLAASYGHLSCLQV 82
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ GA+VD +DVK QT L+ AV +GHL+ ++LLEAGA P GS ++ +PV A+R G
Sbjct: 83 LLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLEAGASPGGSIYNNCSPVLTAARDGA 142
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
IL+ L+ +GA+ +V L P ++ + S PLY++A Y +L CFRLLLL GA
Sbjct: 143 VAILQELLDHGAEANVKAKL-----PVWASNIAS-CSGPLYLAAVYGHLDCFRLLLLHGA 196
Query: 217 NPDFNCNGPVNTQGFYR--GSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPE 274
+PD+NC QG P +++ L H CE ++ LL++FGAN+ L SL
Sbjct: 197 DPDYNC----TDQGLLARVPRPRTLLEICLHHNCEPEYIQLLIDFGANIYLPSL-SLDLT 251
Query: 275 SRGRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGK-HRLHLIPSLPLPDPIKKFLL 333
S+ D + + + +AR+ PR+LL R+ VRRAL + + I L +P + +L
Sbjct: 252 SQ-----DDKGIALLLQARATPRSLLSQVRLVVRRALCQAGQPQAINQLDIPPMLISYLK 306
Query: 334 HE 335
H+
Sbjct: 307 HQ 308
>gi|18254474 ankyrin repeat and SOCS box-containing protein 11
isoform a [Homo sapiens]
Length = 323
Score = 98.6 bits (244), Expect = 7e-21
Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 33/277 (11%)
Query: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
W +PL AA G + LI +G V+LV + ++L+ A + GH+ + LLE GA
Sbjct: 63 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGA 122
Query: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQ---PRFSRRLTSLV 192
NG H +TP+++A G A + L+ +GA + HL + R R ++
Sbjct: 123 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEIL 182
Query: 193 VC--------------PLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
+ PLY++ Y + C + LL GA+ D G + +P
Sbjct: 183 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD---------HGQWLDTP-- 231
Query: 239 VMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRT 298
+ A R + LL ++GANL + K E + +E P
Sbjct: 232 -LHAAARQS-NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG---PPA 286
Query: 299 LLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
L LCR+ VR+ LG+ I L LP+P+++FLL++
Sbjct: 287 LSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 323
>gi|60218887 ankyrin repeat and SOCS box-containing protein 11
isoform b [Homo sapiens]
Length = 302
Score = 98.6 bits (244), Expect = 7e-21
Identities = 76/277 (27%), Positives = 122/277 (44%), Gaps = 33/277 (11%)
Query: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
W +PL AA G + LI +G V+LV + ++L+ A + GH+ + LLE GA
Sbjct: 42 WADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGA 101
Query: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQ---PRFSRRLTSLV 192
NG H +TP+++A G A + L+ +GA + HL + R R ++
Sbjct: 102 HVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEIL 161
Query: 193 VC--------------PLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
+ PLY++ Y + C + LL GA+ D G + +P
Sbjct: 162 LANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVD---------HGQWLDTP-- 210
Query: 239 VMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRT 298
+ A R + LL ++GANL + K E + +E P
Sbjct: 211 -LHAAARQS-NVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREG---PPA 265
Query: 299 LLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE 335
L LCR+ VR+ LG+ I L LP+P+++FLL++
Sbjct: 266 LSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ 302
>gi|18254476 ankyrin repeat and SOCS box-containing protein 5 [Homo
sapiens]
Length = 329
Score = 93.2 bits (230), Expect = 3e-19
Identities = 79/274 (28%), Positives = 119/274 (43%), Gaps = 32/274 (11%)
Query: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
W +PL AA+ G + L+ +G V+ V + T L+ A + H+ + LLEAGA
Sbjct: 68 WADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEACLGDHVACARTLLEAGA 127
Query: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV--------------NHHLTPDVQ 181
+ N TP+++A G + L+ YGA + HH D+
Sbjct: 128 NVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSPTHEAASKGHHECLDIL 187
Query: 182 PRFSRRLTSLVV---CPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
+ + + PLY++ C LL AGA+ +G Y +P
Sbjct: 188 ISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQ---------KGKYWDTP-- 236
Query: 239 VMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRT 298
+ A + V+LL+EFGA++N E L P E + + EA P +
Sbjct: 237 -LHAAAQQS-STEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEA--TPSS 292
Query: 299 LLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFL 332
L LCR+ +R +GK RLHLIP L LP +K FL
Sbjct: 293 LYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFL 326
>gi|72534772 ankyrin repeat and SOCS box-containing 9 isoform 1
[Homo sapiens]
Length = 294
Score = 91.3 bits (225), Expect = 1e-18
Identities = 81/277 (29%), Positives = 129/277 (46%), Gaps = 43/277 (15%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+P+ AA GH + LI +G V+++ + L+ A + GHL +ILL+ GA NG
Sbjct: 38 SPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNG 97
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRR----LTSLVV-- 193
TP+++A G D + L+++GA V L + R + SL+
Sbjct: 98 VTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYG 157
Query: 194 -----------CPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDA 242
PLY++ C + LL +GA+ + QG + SP + A
Sbjct: 158 GNIDHKISHLGTPLYLACENQQRACVKKLLESGADVN---------QGKGQDSP---LHA 205
Query: 243 VLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVD---PEA--LQVFKEARSVPR 297
V R E LL++FGA ++ + G+R V+ PE+ Q+F E R P
Sbjct: 206 VARTASE-ELACLLMDFGA-------DTQAKNAEGKRPVELVPPESPLAQLFLE-REGPP 256
Query: 298 TLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLH 334
+L+ LCR+ +R+ G + H I L LP+ +K+FLLH
Sbjct: 257 SLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLH 293
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 86.3 bits (212), Expect = 4e-17
Identities = 87/325 (26%), Positives = 144/325 (44%), Gaps = 63/325 (19%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G+ + ++ LL S R+RI V +PL +AA H ++ L+
Sbjct: 293 LHIASKKGNYRIVQMLLPVTS-RTRIRRSGV--------SPLHLAAERNHDEVLEALLSA 343
Query: 101 GAEVD---------LVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHA 151
+V+ L + + +ALY AVVN ++ +T++LL+ GADPN +P+ A
Sbjct: 344 RFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVA 400
Query: 152 SRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLL 211
R G ++ L+ +GA++D P P I A L + L
Sbjct: 401 IRHGCLRTMQLLLDHGANIDAYIATHP-------------TAFPATIMFAMKCLSLLKFL 447
Query: 212 LLAGAN--PDFNC---NGP----VNTQGFYRGSPGCVMDAVLRHGCE-----------AA 251
+ G + P F+C NGP + +P + + CE
Sbjct: 448 MDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGP 507
Query: 252 FVSLLVEFGANLNLVKWESLGPESRGRRKVDP-EALQVFKEARSVPRTLLCLCRVAVRRA 310
+ +L+++ N+ L SR + +D E V KE PR L LCR+ VR+A
Sbjct: 508 IIDVLLDYVGNVQLC--------SRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKA 559
Query: 311 LGKHRLHLIPSLPLPDPIKKFLLHE 335
+GK+R+ L+ +LPLP + ++L +E
Sbjct: 560 IGKYRIKLLDTLPLPGRLIRYLKYE 584
Score = 67.8 bits (164), Expect = 1e-11
Identities = 63/227 (27%), Positives = 100/227 (44%), Gaps = 36/227 (15%)
Query: 48 GDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK-GAEVDL 106
GD + L+++++E + N++ GWLP L AA G C+ L R +D
Sbjct: 68 GDEEALKTMIKEGKNLAEPNKE-----GWLP---LHEAAYYGQVGCLKVLQRAYPGTIDQ 119
Query: 107 VDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRY 166
++ +TA+Y+A GHL+ LL+AGA+P+ S R TP+Y A A+ +K L+++
Sbjct: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
Query: 167 GADVDVNHH-------LTPDVQPRFSRRLTSLV-------------VCPLYISAAYHNLQ 206
A D NH L V + LV + PL+++A L+
Sbjct: 180 NA--DTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
Query: 207 CFRLLLLAGANPDFNCNGPVNTQGFY---RGSPGCVMDAVLRHGCEA 250
R L GA D N N Y + V++ +L G +A
Sbjct: 238 ALRFLAKYGA--DINTQASDNASALYEACKNEHEEVVEFLLSQGADA 282
Score = 65.5 bits (158), Expect = 7e-11
Identities = 66/256 (25%), Positives = 109/256 (42%), Gaps = 57/256 (22%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH++ DL+ ++ L+ S +++ K+ + TPL +AA +G + FL
Sbjct: 192 TALHESVSRNDLEVMQILV---SGGAKVESKNAY-----GITPLFVAAQSGQLEALRFLA 243
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA+++ +ALY A N H E + LL GAD N + P++ AS+ G
Sbjct: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
Query: 159 ILKALI---------RYG---------------------ADVDVNHHLTPDVQPRFSRRL 188
I++ L+ R G A DVN L P+ + R
Sbjct: 304 IVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRR 363
Query: 189 TSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGC 248
+S LY + +N+ LLL GA+P+ + P + +RHGC
Sbjct: 364 SS----ALYFAVVNNNVYATELLLQHGADPNRDVISP--------------LLVAIRHGC 405
Query: 249 EAAFVSLLVEFGANLN 264
+ LL++ GAN++
Sbjct: 406 -LRTMQLLLDHGANID 420
Score = 57.0 bits (136), Expect = 2e-08
Identities = 43/159 (27%), Positives = 73/159 (45%), Gaps = 30/159 (18%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVW---------CCGWLPC------------ 79
LH+AAY G + L+ L + +Y I+++++ C G L C
Sbjct: 94 LHEAAYYGQVGCLKVL--QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD 151
Query: 80 -------TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLE 132
TPL A + V L++ A+ + +G TAL+ +V LE QIL+
Sbjct: 152 ISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS 211
Query: 133 AGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD 171
GA + TP++ A++ G+ + L+ L +YGAD++
Sbjct: 212 GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADIN 250
Score = 47.4 bits (111), Expect = 2e-05
Identities = 42/169 (24%), Positives = 76/169 (44%), Gaps = 24/169 (14%)
Query: 75 GWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAG 134
GW T L + + + L+ GA+V+ + G T L+VA +G LE+ + L + G
Sbjct: 190 GW---TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYG 246
Query: 135 ADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDV----------------NHHLTP 178
AD N ++ +Y A + ++++ L+ GAD + N+ +
Sbjct: 247 ADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQ 306
Query: 179 DVQPRFSR-RLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPV 226
+ P SR R+ V PL+++A ++ + LL A F+ N P+
Sbjct: 307 MLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA----RFDVNTPL 351
Score = 36.6 bits (83), Expect = 0.032
Identities = 35/147 (23%), Positives = 61/147 (41%), Gaps = 16/147 (10%)
Query: 78 PCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADP 137
P PL A G + +I++G + + +G L+ A G + ++L A
Sbjct: 57 PADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT 116
Query: 138 NGSRH-HRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPL 196
R T VY A+ G D L +L++ GA+ D+++ SR PL
Sbjct: 117 IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNK---------SRET------PL 161
Query: 197 YISAAYHNLQCFRLLLLAGANPDFNCN 223
Y + N + ++L+ A+ + CN
Sbjct: 162 YKACERKNAEAVKILVQHNADTNHRCN 188
>gi|22208957 ankyrin repeat and SOCS box-containing protein 13 [Homo
sapiens]
Length = 278
Score = 81.3 bits (199), Expect = 1e-15
Identities = 75/282 (26%), Positives = 116/282 (41%), Gaps = 48/282 (17%)
Query: 76 WLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGA 135
W+ TP+ AA G + LI GA V+ V V T L+ A + G Q+LL AGA
Sbjct: 17 WVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGA 76
Query: 136 DPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRF---SRRLTSLV 192
+ STP+ A G + +K L+ YGA V+ + + S L+
Sbjct: 77 QVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLL 136
Query: 193 V--------------CPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGC 238
+ PL+++ A +L C ++LL AGAN VN +
Sbjct: 137 IDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGAN--------VNAAKLH------ 182
Query: 239 VMDAVLRHGCEAA---FVSLLVEFGANLNLVKWESLGPESRGRRKVD-----PEALQVFK 290
+ L H + + +L+EFG N+ ++RG++ D + F+
Sbjct: 183 --ETALHHAAKVKNVDLIEMLIEFGGNI-------YARDNRGKKPSDYTWSSSAPAKCFE 233
Query: 291 EARSVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFL 332
P TL LCRV +R+A G L I L +P + +L
Sbjct: 234 YYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYL 275
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 80.5 bits (197), Expect = 2e-15
Identities = 60/204 (29%), Positives = 101/204 (49%), Gaps = 28/204 (13%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSV--WCCGWLPCTPLRIAATAGHGSCVDFLI 98
+H+AAY ++ L+ L+ +S + I K+ +C L +AA+ GH V L+
Sbjct: 47 IHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCA-------LHLAASQGHWKIVQILL 99
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRS-TPVYHASRVGRA 157
GA+ + ++ T L++AV NG ++ ++LL+ GA+ NGS ++ AS A
Sbjct: 100 EAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENA 159
Query: 158 DILKALIRYGADVDVNHH--LTPDVQPRFSRRLTSLVVC----------------PLYIS 199
+I+K L+R GA+ + +TP +L SL + PL+I+
Sbjct: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
Query: 200 AAYHNLQCFRLLLLAGANPDFNCN 223
A + +C LLL +GA+PD CN
Sbjct: 220 AQEGHTKCVELLLSSGADPDLYCN 243
Score = 75.5 bits (184), Expect = 6e-14
Identities = 67/246 (27%), Positives = 114/246 (46%), Gaps = 46/246 (18%)
Query: 44 AAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGS--CVDFLIRKG 101
AA G+++ LR LL++ + + GW+P I A H S C+ LI
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNR-----GWMP-----IHEAAYHNSVECLQMLINAD 66
Query: 102 AEVDLVDVK---GQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ + + +K G AL++A GH + QILLEAGADPN + +TP++ A G+ D
Sbjct: 67 SSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQID 126
Query: 159 ILKALIRYGADVDVNHHL-------------TPDVQPRFSRR------LTSLVVCPLYIS 199
+L+ L+++GA+V+ +H + ++ R+ + PL+++
Sbjct: 127 VLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVA 186
Query: 200 AAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEF 259
A Y L+ +L+ +GAN VN Q + +P + C V LL+
Sbjct: 187 AQYGKLESLSILISSGAN--------VNCQALDKATPLFIAAQEGHTKC----VELLLSS 234
Query: 260 GANLNL 265
GA+ +L
Sbjct: 235 GADPDL 240
Score = 67.8 bits (164), Expect = 1e-11
Identities = 69/249 (27%), Positives = 110/249 (44%), Gaps = 36/249 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
E T L A G + LR LLQ + + +N S CGW L A+ + +
Sbjct: 112 ETTPLFLAVENGQIDVLRLLLQ---HGANVNG-SHSMCGW---NSLHQASFQENAEIIKL 164
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+RKGA + D G T L+VA G LES IL+ +GA+ N ++TP++ A++ G
Sbjct: 165 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 224
Query: 157 ADILKALIRYGADVDVNHH-------LTPDVQPRFSRRLTSLV-------------VCPL 196
++ L+ GAD D+ + + Q ++ L L+ V P+
Sbjct: 225 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 284
Query: 197 YISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCE-AAFVSL 255
Y + + C +LL G +PD F SP C+ + CE V++
Sbjct: 285 YSAVFGGHEDCLEILLRNGYSPDAQA-----CLVFGFSSPVCM---AFQKDCEFFGIVNI 336
Query: 256 LVEFGANLN 264
L+++GA +N
Sbjct: 337 LLKYGAQIN 345
Score = 49.3 bits (116), Expect = 5e-06
Identities = 83/367 (22%), Positives = 126/367 (34%), Gaps = 102/367 (27%)
Query: 34 EHCED----TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
+ C+D T L AA G L++L L+ + +V C TPL IAA G
Sbjct: 172 KECQDDFGITPLFVAAQYGKLESLSILISSGA--------NVNCQALDKATPLFIAAQEG 223
Query: 90 HGSCVDFLIRKGAEVDL-----------------------------------VDVKGQTA 114
H CV+ L+ GA+ DL + +
Sbjct: 224 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP 283
Query: 115 LYVAVVNGHLESTQILLEAGADPNGSR---HHRSTPVYHASRVGRA--DILKALIRYGAD 169
+Y AV GH + +ILL G P+ S+PV A + I+ L++YGA
Sbjct: 284 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 343
Query: 170 VDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGAN-PDFN-----CN 223
++ H L C Y FR L G + +N N
Sbjct: 344 INELH----------------LAYC-----LKYEKFSIFRYFLRKGCSLGPWNHIYEFVN 382
Query: 224 GPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGA------------NLNLVKWESL 271
+ Q Y+ L H A F L++ + L W++L
Sbjct: 383 HAIKAQAKYK--------EWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTL 434
Query: 272 GPESRGRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGKHRLH---LIPSLPLPDPI 328
P + ++ + +L LCR+ +R +L RL I LPLP +
Sbjct: 435 APAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSL 494
Query: 329 KKFLLHE 335
+LL+E
Sbjct: 495 HNYLLYE 501
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 78.2 bits (191), Expect = 1e-14
Identities = 48/133 (36%), Positives = 72/133 (54%), Gaps = 3/133 (2%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L AAY+G + + LL + + +N + V L L + A+ GH S V LI
Sbjct: 679 TALIAAAYMGHREIVEHLLD---HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLI 735
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GAEVD D G T L VA GH++ +LLE GAD + + ++ TP+ A+ +G A
Sbjct: 736 DRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHAS 795
Query: 159 ILKALIRYGADVD 171
++ L+ +GA VD
Sbjct: 796 VVNTLLFWGAAVD 808
Score = 67.4 bits (163), Expect = 2e-11
Identities = 45/131 (34%), Positives = 68/131 (51%), Gaps = 10/131 (7%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEES-YRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFL 97
T LH + + G ++ ++ L+ + + NEK + L+ AA GH V L
Sbjct: 981 TALHVSCWQGHMEMVQVLIAYHADVNAADNEKR---------SALQSAAWQGHVKVVQLL 1031
Query: 98 IRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRA 157
I GA VD +G TAL +A GH++ Q+LLE GADPN + T + A++ G +
Sbjct: 1032 IEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091
Query: 158 DILKALIRYGA 168
I+K L +YGA
Sbjct: 1092 QIIKLLEKYGA 1102
Score = 62.4 bits (150), Expect = 6e-10
Identities = 49/145 (33%), Positives = 71/145 (48%), Gaps = 13/145 (8%)
Query: 75 GWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAG 134
GW T LR AA GH V L+ G +VD D +TAL A GH + LL+ G
Sbjct: 611 GW---TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 135 ADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVC 194
A+ N + + T + A+ +G +I++ L+ +GA +VNH DV R T+L V
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHGA--EVNHE---DVDGR-----TALSVA 717
Query: 195 PLYISAAYHNLQCFRLLLLAGANPD 219
L + A+ + LL+ GA D
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVD 742
Score = 62.4 bits (150), Expect = 6e-10
Identities = 46/139 (33%), Positives = 69/139 (49%), Gaps = 11/139 (7%)
Query: 33 LEHCED---TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
++HC+ T L AAY G + + LL+ + + TPL AA+ G
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGR--------TPLLAAASMG 792
Query: 90 HGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVY 149
H S V+ L+ GA VD +D +G+T L +A G++E + LL+ G D N TP++
Sbjct: 793 HASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLH 852
Query: 150 HASRVGRADILKALIRYGA 168
A+ G I +ALI GA
Sbjct: 853 MAAFEGHRLICEALIEQGA 871
Score = 55.5 bits (132), Expect = 7e-08
Identities = 28/90 (31%), Positives = 50/90 (55%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
L I A + ++ + GA V+ D +G+TAL+V+ GH+E Q+L+ AD N +
Sbjct: 950 LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVD 171
+ + + + A+ G +++ LI +GA VD
Sbjct: 1010 NEKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039
Score = 54.7 bits (130), Expect = 1e-07
Identities = 40/142 (28%), Positives = 65/142 (45%), Gaps = 15/142 (10%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
LR+AA GH V+ L GA+V+ D G+ LY+ + L + LE GA+ S
Sbjct: 917 LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASD 976
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
T ++ + G ++++ LI Y ADV+ D + R + L +A
Sbjct: 977 AEGRTALHVSCWQGHMEMVQVLIAYHADVN-----AADNEKRSA----------LQSAAW 1021
Query: 202 YHNLQCFRLLLLAGANPDFNCN 223
+++ +LL+ GA D CN
Sbjct: 1022 QGHVKVVQLLIEHGAVVDHTCN 1043
Score = 53.1 bits (126), Expect = 3e-07
Identities = 34/92 (36%), Positives = 48/92 (52%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +AA GH V+ LI GA ++ D G TAL A GH E LL AG +
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVD 171
+ T + A+ G DI+ L+++GA+V+
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Score = 52.8 bits (125), Expect = 4e-07
Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +AA GH VD L+ GA+VD D G+T L A GH LL GA +
Sbjct: 750 TPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDS 809
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNH 174
T + AS G ++++ L+ G +D NH
Sbjct: 810 IDSEGRTVLSIASAQGNVEVVRTLLDRG--LDENH 842
Score = 52.4 bits (124), Expect = 6e-07
Identities = 41/150 (27%), Positives = 74/150 (49%), Gaps = 16/150 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
T L ++ GH V LI A+V+ D + ++AL A GH++ Q+L+E GA +
Sbjct: 981 TALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDH 1040
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ + +T + A++ G D+++ L+ +GAD P+ +F R + ++
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGAD--------PNHADQFGR-------TAMRVA 1085
Query: 200 AAYHNLQCFRLLLLAGANPDFNCN-GPVNT 228
A + Q +LL GA+ C+ PV+T
Sbjct: 1086 AKNGHSQIIKLLEKYGASSLNGCSPSPVHT 1115
Score = 50.4 bits (119), Expect = 2e-06
Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 1/119 (0%)
Query: 54 RSLLQEESYRSRI-NEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQ 112
++L +E+S R+ + N SV C T L AA +G V+ L+ +GA++++ D G
Sbjct: 520 QALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGH 579
Query: 113 TALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD 171
T L +A GH + L+ GA+ N + T + A+ G +++ AL+ G VD
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVD 638
Score = 47.8 bits (112), Expect = 1e-05
Identities = 32/135 (23%), Positives = 59/135 (43%), Gaps = 8/135 (5%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G +L+++ + + I+ P +A+ GH CV L+
Sbjct: 849 TPLHMAAFEGHRLICEALIEQGARTNEIDNDGR--------IPFILASQEGHYDCVQILL 900
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ +D G+ AL VA + GH + ++L GAD N +Y + +
Sbjct: 901 ENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLT 960
Query: 159 ILKALIRYGADVDVN 173
+ + + GA+V+ +
Sbjct: 961 MAEYFLENGANVEAS 975
>gi|215598806 ankyrin repeat and SOCS box-containing 10 isoform 3
[Homo sapiens]
Length = 452
Score = 74.3 bits (181), Expect = 1e-13
Identities = 56/198 (28%), Positives = 87/198 (43%), Gaps = 29/198 (14%)
Query: 36 CEDTRLHDAAYVGDLQTLRSLLQEESYRSRI------------NEKSVWCCGWLP--CTP 81
C+D L +A Y GDL L+ L S + +++ +W + TP
Sbjct: 45 CQDMALQNALYTGDLARLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTP 104
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
L +AA+ GH + L+R+ A D G+TAL+ A GH +LL AGADPN +
Sbjct: 105 LHVAASRGHTEVLRLLLRRRARPDSAP-GGRTALHEACAAGHTACVHVLLVAGADPNIAD 163
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
P++ G + + L+R+GA VD + PL+++A
Sbjct: 164 QDGKRPLHLCRGPGTLECAELLLRFGARVDGRSEEEEET--------------PLHVAAR 209
Query: 202 YHNLQCFRLLLLAGANPD 219
+++ LLL GA PD
Sbjct: 210 LGHVELADLLLRRGACPD 227
Score = 50.1 bits (118), Expect = 3e-06
Identities = 70/276 (25%), Positives = 108/276 (39%), Gaps = 57/276 (20%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYV-------------AVVNGHLES 126
TPL +AA GH D L+R+GA D + +G T L A L+
Sbjct: 202 TPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACDVRCQSITDAEATTARCLQL 261
Query: 127 TQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGAD---VDVNHHLTPDVQPR 183
+LL AGAD + + + P++ A R G A +++ L+ G +D H TP
Sbjct: 262 CSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYGGH-TP----- 315
Query: 184 FSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAV 243
+ C L AA +P+ +N G R PG + +
Sbjct: 316 --------LHCALQGPAA-----------ALAQSPEHVVRALLN-HGAVRVWPGALPKVL 355
Query: 244 LRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARS-------VP 296
R + +L+ + + L + E++G V PE LQ + S P
Sbjct: 356 ERWSTCPRTIEVLMNTYSVVQLPE-EAVG-------LVTPETLQKHQRFYSSLFALVRQP 407
Query: 297 RTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFL 332
R+L L R A+R L +P LPLP + ++L
Sbjct: 408 RSLQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYL 443
Score = 42.0 bits (97), Expect = 8e-04
Identities = 47/170 (27%), Positives = 70/170 (41%), Gaps = 25/170 (14%)
Query: 34 EHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLP--------CTPLRIA 85
E E+T LH AA +G ++ LL+ + N + GW P C + A
Sbjct: 197 EEEEETPLHVAARLGHVELADLLLRRGACPDARNAE-----GWTPLLAACDVRCQSITDA 251
Query: 86 --ATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHH 143
TA L+ GA+ D D Q L++A GH ++LL G N +
Sbjct: 252 EATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCGVSANTMDYG 311
Query: 144 RSTPVYHASRVGRA--------DILKALIRYGADVDVNHHLTPDVQPRFS 185
TP+ H + G A +++AL+ +GA V V P V R+S
Sbjct: 312 GHTPL-HCALQGPAAALAQSPEHVVRALLNHGA-VRVWPGALPKVLERWS 359
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/210 (28%), Positives = 97/210 (46%), Gaps = 24/210 (11%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA G Q + LL+ + + + +PL +AA H CV L+
Sbjct: 280 TPLHCAARSGHDQVVELLLERGAPLLARTKNGL--------SPLHMAAQGDHVECVKHLL 331
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A VD V + TAL+VA GH T++LL+ A+PN + TP++ A + R
Sbjct: 332 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 391
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+++ L++YGA + + +T + P++++A +L LLL GA+P
Sbjct: 392 VMELLVKYGASI---------------QAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 219 DF-NCNGPVNTQGFYRGSPGCVMDAVLRHG 247
D N G R V+ +LR+G
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNG 466
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/178 (28%), Positives = 86/178 (48%), Gaps = 23/178 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A ++ + L++ + I E + TP+ +AA GH + V L+
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGL--------TPIHVAAFMGHLNIVLLLL 430
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA D+ +++G+TAL++A G +E + LL GA + TP++ ASR+G+ +
Sbjct: 431 QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 490
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
I++ L+++ A D T+ PL+ISA + +LL AGA
Sbjct: 491 IVQLLLQHMAHPDA---------------ATTNGYTPLHISAREGQVDVASVLLEAGA 533
Score = 67.0 bits (162), Expect = 2e-11
Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESY-RSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+T LH AA G ++ +R LL+ + +R E+ TPL IA+ G V
Sbjct: 444 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---------TPLHIASRLGKTEIVQL 494
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L++ A D G T L+++ G ++ +LLEAGA + + TP++ A++ G
Sbjct: 495 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 554
Query: 157 ADILKALI--RYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLA 214
D+ K L+ R AD + LT PL+++A Y N + LLL
Sbjct: 555 LDVAKLLLQRRAAADSAGKNGLT-----------------PLHVAAHYDNQKVALLLLEK 597
Query: 215 GANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
GA+P G + + S L+ +GA N+V + + P
Sbjct: 598 GASPHATAKN------------GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 644
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 24/212 (11%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ D Q + LL E+ K+ + TPL IAA L+
Sbjct: 577 TPLHVAAHY-DNQKVALLLLEKGASPHATAKNGY-------TPLHIAAKKNQMQIASTLL 628
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
GAE ++V +G T L++A GH + +LL+ GA+ + S T ++ A++ + +
Sbjct: 629 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 688
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ L ++GAD D + T L PL ++ Y N++ LL GAN
Sbjct: 689 VADILTKHGADQDAH---------------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 733
Query: 219 DFNC-NGPVNTQGFYRGSPGCVMDAVLRHGCE 249
+ NG + +++ +L+HG +
Sbjct: 734 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 765
Score = 61.2 bits (147), Expect = 1e-09
Identities = 31/88 (35%), Positives = 51/88 (57%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
L +AA GH V L+ +G+ VD KG TAL++A + G E ++L++ GA+ N
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 106
Query: 142 HHRSTPVYHASRVGRADILKALIRYGAD 169
+ TP+Y A++ D++K L+ GA+
Sbjct: 107 QNGFTPLYMAAQENHIDVVKYLLENGAN 134
Score = 56.6 bits (135), Expect = 3e-08
Identities = 47/172 (27%), Positives = 77/172 (44%), Gaps = 15/172 (8%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH AA D ++ LLQ + ++ V TPL IAA G+ + L+ +
Sbjct: 175 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 234
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA VD G T L+VA G+ ++LL+ G + TP++ A+R G ++
Sbjct: 235 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 294
Query: 161 KALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLL 212
+ L+ GA P +R L PL+++A +++C + LL
Sbjct: 295 ELLLERGA-------------PLLARTKNGL--SPLHMAAQGDHVECVKHLL 331
Score = 56.2 bits (134), Expect = 4e-08
Identities = 56/209 (26%), Positives = 82/209 (39%), Gaps = 32/209 (15%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH AA G + ++ LL S +K T L IA+ AG V L+++
Sbjct: 47 LHLAAKEGHVGLVQELLGRGSSVDSATKKGN--------TALHIASLAGQAEVVKVLVKE 98
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA ++ G T LY+A H++ + LLE GA+ + + TP+ A + G +
Sbjct: 99 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 158
Query: 161 KALIRYGADVDV----------------------NHHLTPDVQPRFS-RRLTSLVVCPLY 197
L+ V N H DVQ + R T PL+
Sbjct: 159 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH-NADVQSKMMVNRTTESGFTPLH 217
Query: 198 ISAAYHNLQCFRLLLLAGANPDFNCNGPV 226
I+A Y N+ LLL GA DF +
Sbjct: 218 IAAHYGNVNVATLLLNRGAAVDFTARNGI 246
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 35/235 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G++ LL + + TPL +A+ G+ + V L+
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--------TPLHVASKRGNTNMVKLLL 265
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+G ++D G T L+ A +GH + ++LLE GA + +P++ A++ +
Sbjct: 266 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 325
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+K L+++ A VD +T + L+++A + + +LLL ANP
Sbjct: 326 CVKHLLQHKAPVD---------------DVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
+ GF C + + + LLV++GA++ + L P
Sbjct: 371 NARA-----LNGFTPLHIACKKNRI-------KVMELLVKYGASIQAITESGLTP 413
Score = 52.4 bits (124), Expect = 6e-07
Identities = 28/84 (33%), Positives = 45/84 (53%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A G+ V+FL+++GA V+ G T L+ A GH +LL+ GA PN
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 768
Query: 140 SRHHRSTPVYHASRVGRADILKAL 163
+ + +T + A R+G ++ L
Sbjct: 769 TTANGNTALAIAKRLGYISVVDTL 792
Score = 52.0 bits (123), Expect = 7e-07
Identities = 36/133 (27%), Positives = 68/133 (51%), Gaps = 15/133 (11%)
Query: 85 AATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHR 144
AA AG+ V ++ G +++ + G AL++A GH+ Q LL G+ + +
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 145 STPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHN 204
+T ++ AS G+A+++K L++ GA+++ Q F+ PLY++A ++
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQS------QNGFT---------PLYMAAQENH 121
Query: 205 LQCFRLLLLAGAN 217
+ + LL GAN
Sbjct: 122 IDVVKYLLENGAN 134
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/210 (28%), Positives = 97/210 (46%), Gaps = 24/210 (11%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA G Q + LL+ + + + +PL +AA H CV L+
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGL--------SPLHMAAQGDHVECVKHLL 352
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A VD V + TAL+VA GH T++LL+ A+PN + TP++ A + R
Sbjct: 353 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+++ L++YGA + + +T + P++++A +L LLL GA+P
Sbjct: 413 VMELLVKYGASI---------------QAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 219 DF-NCNGPVNTQGFYRGSPGCVMDAVLRHG 247
D N G R V+ +LR+G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/178 (28%), Positives = 86/178 (48%), Gaps = 23/178 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A ++ + L++ + I E + TP+ +AA GH + V L+
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGL--------TPIHVAAFMGHLNIVLLLL 451
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA D+ +++G+TAL++A G +E + LL GA + TP++ ASR+G+ +
Sbjct: 452 QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
I++ L+++ A D T+ PL+ISA + +LL AGA
Sbjct: 512 IVQLLLQHMAHPDA---------------ATTNGYTPLHISAREGQVDVASVLLEAGA 554
Score = 67.0 bits (162), Expect = 2e-11
Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESY-RSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+T LH AA G ++ +R LL+ + +R E+ TPL IA+ G V
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---------TPLHIASRLGKTEIVQL 515
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L++ A D G T L+++ G ++ +LLEAGA + + TP++ A++ G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 157 ADILKALI--RYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLA 214
D+ K L+ R AD + LT PL+++A Y N + LLL
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLT-----------------PLHVAAHYDNQKVALLLLEK 618
Query: 215 GANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
GA+P G + + S L+ +GA N+V + + P
Sbjct: 619 GASPHATAKN------------GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 24/212 (11%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ D Q + LL E+ K+ + TPL IAA L+
Sbjct: 598 TPLHVAAHY-DNQKVALLLLEKGASPHATAKNGY-------TPLHIAAKKNQMQIASTLL 649
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
GAE ++V +G T L++A GH + +LL+ GA+ + S T ++ A++ + +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 709
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ L ++GAD D + T L PL ++ Y N++ LL GAN
Sbjct: 710 VADILTKHGADQDAH---------------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 219 DFNC-NGPVNTQGFYRGSPGCVMDAVLRHGCE 249
+ NG + +++ +L+HG +
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Score = 61.2 bits (147), Expect = 1e-09
Identities = 31/88 (35%), Positives = 51/88 (57%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
L +AA GH V L+ +G+ VD KG TAL++A + G E ++L++ GA+ N
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 142 HHRSTPVYHASRVGRADILKALIRYGAD 169
+ TP+Y A++ D++K L+ GA+
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN 155
Score = 56.6 bits (135), Expect = 3e-08
Identities = 47/172 (27%), Positives = 77/172 (44%), Gaps = 15/172 (8%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH AA D ++ LLQ + ++ V TPL IAA G+ + L+ +
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA VD G T L+VA G+ ++LL+ G + TP++ A+R G ++
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 161 KALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLL 212
+ L+ GA P +R L PL+++A +++C + LL
Sbjct: 316 ELLLERGA-------------PLLARTKNGL--SPLHMAAQGDHVECVKHLL 352
Score = 56.2 bits (134), Expect = 4e-08
Identities = 56/209 (26%), Positives = 82/209 (39%), Gaps = 32/209 (15%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH AA G + ++ LL S +K T L IA+ AG V L+++
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGN--------TALHIASLAGQAEVVKVLVKE 119
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA ++ G T LY+A H++ + LLE GA+ + + TP+ A + G +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179
Query: 161 KALIRYGADVDV----------------------NHHLTPDVQPRFS-RRLTSLVVCPLY 197
L+ V N H DVQ + R T PL+
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH-NADVQSKMMVNRTTESGFTPLH 238
Query: 198 ISAAYHNLQCFRLLLLAGANPDFNCNGPV 226
I+A Y N+ LLL GA DF +
Sbjct: 239 IAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 35/235 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G++ LL + + TPL +A+ G+ + V L+
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--------TPLHVASKRGNTNMVKLLL 286
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+G ++D G T L+ A +GH + ++LLE GA + +P++ A++ +
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+K L+++ A VD +T + L+++A + + +LLL ANP
Sbjct: 347 CVKHLLQHKAPVD---------------DVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
+ GF C + + + LLV++GA++ + L P
Sbjct: 392 NARA-----LNGFTPLHIACKKNRI-------KVMELLVKYGASIQAITESGLTP 434
Score = 52.4 bits (124), Expect = 6e-07
Identities = 28/84 (33%), Positives = 45/84 (53%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A G+ V+FL+++GA V+ G T L+ A GH +LL+ GA PN
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 140 SRHHRSTPVYHASRVGRADILKAL 163
+ + +T + A R+G ++ L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
Score = 52.0 bits (123), Expect = 7e-07
Identities = 36/133 (27%), Positives = 68/133 (51%), Gaps = 15/133 (11%)
Query: 85 AATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHR 144
AA AG+ V ++ G +++ + G AL++A GH+ Q LL G+ + +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 145 STPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHN 204
+T ++ AS G+A+++K L++ GA+++ Q F+ PLY++A ++
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQS------QNGFT---------PLYMAAQENH 142
Query: 205 LQCFRLLLLAGAN 217
+ + LL GAN
Sbjct: 143 IDVVKYLLENGAN 155
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 73.9 bits (180), Expect = 2e-13
Identities = 60/210 (28%), Positives = 97/210 (46%), Gaps = 24/210 (11%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA G Q + LL+ + + + +PL +AA H CV L+
Sbjct: 301 TPLHCAARSGHDQVVELLLERGAPLLARTKNGL--------SPLHMAAQGDHVECVKHLL 352
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A VD V + TAL+VA GH T++LL+ A+PN + TP++ A + R
Sbjct: 353 QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIK 412
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+++ L++YGA + + +T + P++++A +L LLL GA+P
Sbjct: 413 VMELLVKYGASI---------------QAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 219 DF-NCNGPVNTQGFYRGSPGCVMDAVLRHG 247
D N G R V+ +LR+G
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Score = 68.2 bits (165), Expect = 1e-11
Identities = 50/178 (28%), Positives = 86/178 (48%), Gaps = 23/178 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A ++ + L++ + I E + TP+ +AA GH + V L+
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGL--------TPIHVAAFMGHLNIVLLLL 451
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA D+ +++G+TAL++A G +E + LL GA + TP++ ASR+G+ +
Sbjct: 452 QNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
I++ L+++ A D T+ PL+ISA + +LL AGA
Sbjct: 512 IVQLLLQHMAHPDA---------------ATTNGYTPLHISAREGQVDVASVLLEAGA 554
Score = 67.0 bits (162), Expect = 2e-11
Identities = 62/239 (25%), Positives = 100/239 (41%), Gaps = 41/239 (17%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESY-RSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+T LH AA G ++ +R LL+ + +R E+ TPL IA+ G V
Sbjct: 465 ETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---------TPLHIASRLGKTEIVQL 515
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L++ A D G T L+++ G ++ +LLEAGA + + TP++ A++ G
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575
Query: 157 ADILKALI--RYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLA 214
D+ K L+ R AD + LT PL+++A Y N + LLL
Sbjct: 576 LDVAKLLLQRRAAADSAGKNGLT-----------------PLHVAAHYDNQKVALLLLEK 618
Query: 215 GANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
GA+P G + + S L+ +GA N+V + + P
Sbjct: 619 GASPHATAKN------------GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP 665
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/212 (26%), Positives = 94/212 (44%), Gaps = 24/212 (11%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ D Q + LL E+ K+ + TPL IAA L+
Sbjct: 598 TPLHVAAHY-DNQKVALLLLEKGASPHATAKNGY-------TPLHIAAKKNQMQIASTLL 649
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
GAE ++V +G T L++A GH + +LL+ GA+ + S T ++ A++ + +
Sbjct: 650 NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVN 709
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ L ++GAD D + T L PL ++ Y N++ LL GAN
Sbjct: 710 VADILTKHGADQDAH---------------TKLGYTPLIVACHYGNVKMVNFLLKQGANV 754
Query: 219 DFNC-NGPVNTQGFYRGSPGCVMDAVLRHGCE 249
+ NG + +++ +L+HG +
Sbjct: 755 NAKTKNGYTPLHQAAQQGHTHIINVLLQHGAK 786
Score = 61.2 bits (147), Expect = 1e-09
Identities = 31/88 (35%), Positives = 51/88 (57%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
L +AA GH V L+ +G+ VD KG TAL++A + G E ++L++ GA+ N
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS 127
Query: 142 HHRSTPVYHASRVGRADILKALIRYGAD 169
+ TP+Y A++ D++K L+ GA+
Sbjct: 128 QNGFTPLYMAAQENHIDVVKYLLENGAN 155
Score = 56.6 bits (135), Expect = 3e-08
Identities = 47/172 (27%), Positives = 77/172 (44%), Gaps = 15/172 (8%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH AA D ++ LLQ + ++ V TPL IAA G+ + L+ +
Sbjct: 196 LHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNR 255
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA VD G T L+VA G+ ++LL+ G + TP++ A+R G ++
Sbjct: 256 GAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVV 315
Query: 161 KALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLL 212
+ L+ GA P +R L PL+++A +++C + LL
Sbjct: 316 ELLLERGA-------------PLLARTKNGL--SPLHMAAQGDHVECVKHLL 352
Score = 56.2 bits (134), Expect = 4e-08
Identities = 56/209 (26%), Positives = 82/209 (39%), Gaps = 32/209 (15%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH AA G + ++ LL S +K T L IA+ AG V L+++
Sbjct: 68 LHLAAKEGHVGLVQELLGRGSSVDSATKKGN--------TALHIASLAGQAEVVKVLVKE 119
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA ++ G T LY+A H++ + LLE GA+ + + TP+ A + G +
Sbjct: 120 GANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAV 179
Query: 161 KALIRYGADVDV----------------------NHHLTPDVQPRFS-RRLTSLVVCPLY 197
L+ V N H DVQ + R T PL+
Sbjct: 180 AILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDH-NADVQSKMMVNRTTESGFTPLH 238
Query: 198 ISAAYHNLQCFRLLLLAGANPDFNCNGPV 226
I+A Y N+ LLL GA DF +
Sbjct: 239 IAAHYGNVNVATLLLNRGAAVDFTARNGI 267
Score = 55.5 bits (132), Expect = 7e-08
Identities = 54/235 (22%), Positives = 100/235 (42%), Gaps = 35/235 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G++ LL + + TPL +A+ G+ + V L+
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI--------TPLHVASKRGNTNMVKLLL 286
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+G ++D G T L+ A +GH + ++LLE GA + +P++ A++ +
Sbjct: 287 DRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVE 346
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+K L+++ A VD +T + L+++A + + +LLL ANP
Sbjct: 347 CVKHLLQHKAPVD---------------DVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
+ GF C + + + LLV++GA++ + L P
Sbjct: 392 NARA-----LNGFTPLHIACKKNRI-------KVMELLVKYGASIQAITESGLTP 434
Score = 52.4 bits (124), Expect = 6e-07
Identities = 28/84 (33%), Positives = 45/84 (53%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A G+ V+FL+++GA V+ G T L+ A GH +LL+ GA PN
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNA 789
Query: 140 SRHHRSTPVYHASRVGRADILKAL 163
+ + +T + A R+G ++ L
Sbjct: 790 TTANGNTALAIAKRLGYISVVDTL 813
Score = 52.0 bits (123), Expect = 7e-07
Identities = 36/133 (27%), Positives = 68/133 (51%), Gaps = 15/133 (11%)
Query: 85 AATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHR 144
AA AG+ V ++ G +++ + G AL++A GH+ Q LL G+ + +
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 145 STPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHN 204
+T ++ AS G+A+++K L++ GA+++ Q F+ PLY++A ++
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQS------QNGFT---------PLYMAAQENH 142
Query: 205 LQCFRLLLLAGAN 217
+ + LL GAN
Sbjct: 143 IDVVKYLLENGAN 155
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 71.6 bits (174), Expect = 9e-13
Identities = 53/181 (29%), Positives = 86/181 (47%), Gaps = 35/181 (19%)
Query: 41 LHDAAYVGDLQTLRS------LLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCV 94
+HDA GD++ L LL + + + + GW T IAA G +CV
Sbjct: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGADITHVTTR-----GW---TASHIAAIRGQDACV 81
Query: 95 DFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRV 154
LI GA + D +G T L++A +GH + QI+L +G DP+ + PV++A+
Sbjct: 82 QALIMNGANLTAQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFH 141
Query: 155 GRADILKALIRYGA---DVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLL 211
GR L+ L+++G DVD N +L P++++A +L CF+ L
Sbjct: 142 GRLGCLQLLVKWGCSIEDVDYNGNL------------------PVHLAAMEGHLHCFKFL 183
Query: 212 L 212
+
Sbjct: 184 V 184
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/91 (31%), Positives = 48/91 (52%), Gaps = 7/91 (7%)
Query: 42 HDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKG 101
H AA+ GDL L+ L+++ INE++ TP+ AA GH C+ +LI+ G
Sbjct: 241 HVAAFKGDLGMLKKLVEDGVIN--INERAD-----NGSTPMHKAAGQGHIECLQWLIKMG 293
Query: 102 AEVDLVDVKGQTALYVAVVNGHLESTQILLE 132
A+ ++ + G+ VA HL + ++L E
Sbjct: 294 ADSNITNKAGERPSDVAKRFAHLAAVKLLEE 324
Score = 35.4 bits (80), Expect = 0.072
Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 8/94 (8%)
Query: 100 KGAEVDLVDVKGQTAL----YVAVVNGHLESTQILLEAGA-DPNGSRHHRSTPVYHASRV 154
+GAE + D++ Q L +VA G L + L+E G + N + STP++ A+
Sbjct: 221 QGAEYEGKDLEDQETLAFPGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQ 280
Query: 155 GRADILKALIRYGADVDVNH---HLTPDVQPRFS 185
G + L+ LI+ GAD ++ + DV RF+
Sbjct: 281 GHIECLQWLIKMGADSNITNKAGERPSDVAKRFA 314
Score = 30.0 bits (66), Expect = 3.0
Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 4/93 (4%)
Query: 81 PLRIAATAGHGSCVDFLIRKGA-EVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
P +AA G + L+ G ++ G T ++ A GH+E Q L++ GAD N
Sbjct: 239 PGHVAAFKGDLGMLKKLVEDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADSNI 298
Query: 140 SRHHRSTPVYHASR---VGRADILKALIRYGAD 169
+ P A R + +L+ L +Y D
Sbjct: 299 TNKAGERPSDVAKRFAHLAAVKLLEELQKYDID 331
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 71.2 bits (173), Expect = 1e-12
Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T +H AA++G + + L+ + + N + T L +AA +G V +L+
Sbjct: 435 TPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE--------TALHMAARSGQAEVVRYLV 486
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA+V+ QT L+++ G + Q LL+ GA PN + TP++ ++R G D
Sbjct: 487 QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ L+ +GA + + T PL+++A Y L+ LLL A+P
Sbjct: 547 VAAFLLDHGASLSIT---------------TKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 219 D 219
D
Sbjct: 592 D 592
Score = 66.2 bits (160), Expect = 4e-11
Identities = 51/181 (28%), Positives = 84/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G + + LL +++ N + G+ TPL IA ++ L+
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKA-----NPNAKALNGF---TPLHIACKKNRIKVMELLL 420
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA + V G T ++VA GH+ L+ GA PN + T ++ A+R G+A+
Sbjct: 421 KHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAE 480
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+++ L++ GA V+ D Q PL+ISA + LL GA+P
Sbjct: 481 VVRYLVQDGAQVEAK---AKDDQ------------TPLHISARLGKADIVQQLLQQGASP 525
Query: 219 D 219
+
Sbjct: 526 N 526
Score = 60.1 bits (144), Expect = 3e-09
Identities = 64/270 (23%), Positives = 105/270 (38%), Gaps = 35/270 (12%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G ++ + LLQ E+ +K T L IA+ AG V L+
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGN--------TALHIASLAGQAEVVKVLVTN 129
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA V+ G T LY+A HLE + LL+ GA + + TP+ A + G ++
Sbjct: 130 GANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVV 189
Query: 161 KALIRYGADVDVNHHLTPDVQPRFSRRLTSLVV--------------CPLYISAAYHNLQ 206
L+ V + + +L++ PL+I+A Y N+
Sbjct: 190 SLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNIN 249
Query: 207 CFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLV 266
LLL A DF + + + G A V LL++ GA ++
Sbjct: 250 VATLLLNRAAAVDFTARNDITP-----------LHVASKRG-NANMVKLLLDRGAKIDAK 297
Query: 267 KWESLGPESRGRRKVDPEALQVFKEARSVP 296
+ L P G R + +++ + R+ P
Sbjct: 298 TRDGLTPLHCGARSGHEQVVEMLLD-RAAP 326
Score = 58.9 bits (141), Expect = 6e-09
Identities = 36/140 (25%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+PL +A H +CV L++ VD V TAL+VA GH + ++LL+ A+PN
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ TP++ A + R +++ L+++GA + + +T + P++++
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASI---------------QAVTESGLTPIHVA 440
Query: 200 AAYHNLQCFRLLLLAGANPD 219
A ++ L+ GA+P+
Sbjct: 441 AFMGHVNIVSQLMHHGASPN 460
Score = 57.8 bits (138), Expect = 1e-08
Identities = 61/237 (25%), Positives = 98/237 (41%), Gaps = 35/237 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+ T LH +A +G ++ LLQ+ + + + G+ TPL ++A GH F
Sbjct: 499 DQTPLHISARLGKADIVQQLLQQGA-----SPNAATTSGY---TPLHLSAREGHEDVAAF 550
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ GA + + KG T L+VA G LE +LL+ A P+ + TP++ A+
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
+ L+ GA +P + PL+I+A + + LL GA
Sbjct: 611 QKVALLLLDQGA--------SPHAAAKNG-------YTPLHIAAKKNQMDIATTLLEYGA 655
Query: 217 NPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
+ + V QG + + G VSLL+ AN+NL L P
Sbjct: 656 DAN-----AVTRQGI------ASVHLAAQEG-HVDMVSLLLGRNANVNLSNKSGLTP 700
Score = 56.2 bits (134), Expect = 4e-08
Identities = 45/174 (25%), Positives = 76/174 (43%), Gaps = 23/174 (13%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ D Q + LL ++ K+ + TPL IAA L+
Sbjct: 600 TPLHVAAHY-DNQKVALLLLDQGASPHAAAKNGY-------TPLHIAAKKNQMDIATTLL 651
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
GA+ + V +G ++++A GH++ +LL A+ N S TP++ A++ R +
Sbjct: 652 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLL 212
+ + L+ GA VD T + PL++ Y N++ LL
Sbjct: 712 VAEVLVNQGAHVDAQ---------------TKMGYTPLHVGCHYGNIKIVNFLL 750
Score = 54.7 bits (130), Expect = 1e-07
Identities = 38/133 (28%), Positives = 69/133 (51%), Gaps = 15/133 (11%)
Query: 85 AATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHR 144
AA AGH I+ G ++++ + G AL++A GH+E LL+ A+ + +
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 145 STPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHN 204
+T ++ AS G+A+++K L+ GA+V+ Q F+ PLY++A ++
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQS------QNGFT---------PLYMAAQENH 152
Query: 205 LQCFRLLLLAGAN 217
L+ + LL GA+
Sbjct: 153 LEVVKFLLDNGAS 165
Score = 51.2 bits (121), Expect = 1e-06
Identities = 49/219 (22%), Positives = 95/219 (43%), Gaps = 28/219 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G++ LL + + TPL +A+ G+ + V L+
Sbjct: 237 TPLHIAAHYGNINVATLLLNRAAAVDFTARNDI--------TPLHVASKRGNANMVKLLL 288
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GA++D G T L+ +GH + ++LL+ A + +P++ A++ +
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 159 ILKALIRYGADVD--VNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
++ L+++ VD N +LT L+++A + + ++LL A
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLT-----------------ALHVAAHCGHYKVAKVLLDKKA 391
Query: 217 NPDFNC-NGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVS 254
NP+ NG + + VM+ +L+HG V+
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVT 430
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/128 (25%), Positives = 58/128 (45%), Gaps = 8/128 (6%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
+H AA G + + LL + + N+ + TPL +AA + + L+ +
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGL--------TPLHLAAQEDRVNVAEVLVNQ 719
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA VD G T L+V G+++ LL+ A N + TP++ A++ G I+
Sbjct: 720 GAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHII 779
Query: 161 KALIRYGA 168
L++ A
Sbjct: 780 NVLLQNNA 787
Score = 43.5 bits (101), Expect = 3e-04
Identities = 25/84 (29%), Positives = 41/84 (48%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL + G+ V+FL++ A+V+ G T L+ A GH +LL+ A PN
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNE 791
Query: 140 SRHHRSTPVYHASRVGRADILKAL 163
+ +T + A R+G ++ L
Sbjct: 792 LTVNGNTALGIARRLGYISVVDTL 815
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 71.2 bits (173), Expect = 1e-12
Identities = 50/161 (31%), Positives = 82/161 (50%), Gaps = 19/161 (11%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
L +AA+ GH V L+ GA+ + ++ T L++AV NG ++ ++LL+ GA+ NGS
Sbjct: 10 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 69
Query: 142 HHRS-TPVYHASRVGRADILKALIRYGADVDV--NHHLTPDVQPRFSRRLTSLVV----- 193
++ AS A+I+K L+R GA+ + + +TP +L SL +
Sbjct: 70 SMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG 129
Query: 194 -----------CPLYISAAYHNLQCFRLLLLAGANPDFNCN 223
PL+I+A + +C LLL +GA+PD CN
Sbjct: 130 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCN 170
Score = 67.8 bits (164), Expect = 1e-11
Identities = 69/249 (27%), Positives = 110/249 (44%), Gaps = 36/249 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
E T L A G + LR LLQ + + +N S CGW L A+ + +
Sbjct: 39 ETTPLFLAVENGQIDVLRLLLQ---HGANVNG-SHSMCGW---NSLHQASFQENAEIIKL 91
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+RKGA + D G T L+VA G LES IL+ +GA+ N ++TP++ A++ G
Sbjct: 92 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 151
Query: 157 ADILKALIRYGADVDVNHH-------LTPDVQPRFSRRLTSLV-------------VCPL 196
++ L+ GAD D+ + + Q ++ L L+ V P+
Sbjct: 152 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 211
Query: 197 YISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCE-AAFVSL 255
Y + + C +LL G +PD F SP C+ + CE V++
Sbjct: 212 YSAVFGGHEDCLEILLRNGYSPDAQA-----CLVFGFSSPVCM---AFQKDCEFFGIVNI 263
Query: 256 LVEFGANLN 264
L+++GA +N
Sbjct: 264 LLKYGAQIN 272
Score = 65.5 bits (158), Expect = 7e-11
Identities = 49/175 (28%), Positives = 84/175 (48%), Gaps = 31/175 (17%)
Query: 110 KGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGAD 169
+G AL++A GH + QILLEAGADPN + +TP++ A G+ D+L+ L+++GA+
Sbjct: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
Query: 170 VDVNHHL-------------TPDVQPRFSRR------LTSLVVCPLYISAAYHNLQCFRL 210
V+ +H + ++ R+ + PL+++A Y L+ +
Sbjct: 65 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 124
Query: 211 LLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNL 265
L+ +GAN VN Q + +P + C V LL+ GA+ +L
Sbjct: 125 LISSGAN--------VNCQALDKATPLFIAAQEGHTKC----VELLLSSGADPDL 167
Score = 49.3 bits (116), Expect = 5e-06
Identities = 83/367 (22%), Positives = 126/367 (34%), Gaps = 102/367 (27%)
Query: 34 EHCED----TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
+ C+D T L AA G L++L L+ + +V C TPL IAA G
Sbjct: 99 KECQDDFGITPLFVAAQYGKLESLSILISSGA--------NVNCQALDKATPLFIAAQEG 150
Query: 90 HGSCVDFLIRKGAEVDL-----------------------------------VDVKGQTA 114
H CV+ L+ GA+ DL + +
Sbjct: 151 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP 210
Query: 115 LYVAVVNGHLESTQILLEAGADPNGSR---HHRSTPVYHASRVGRA--DILKALIRYGAD 169
+Y AV GH + +ILL G P+ S+PV A + I+ L++YGA
Sbjct: 211 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 270
Query: 170 VDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGAN-PDFN-----CN 223
++ H L C Y FR L G + +N N
Sbjct: 271 INELH----------------LAYC-----LKYEKFSIFRYFLRKGCSLGPWNHIYEFVN 309
Query: 224 GPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGA------------NLNLVKWESL 271
+ Q Y+ L H A F L++ + L W++L
Sbjct: 310 HAIKAQAKYK--------EWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTL 361
Query: 272 GPESRGRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGKHRLH---LIPSLPLPDPI 328
P + ++ + +L LCR+ +R +L RL I LPLP +
Sbjct: 362 APAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSL 421
Query: 329 KKFLLHE 335
+LL+E
Sbjct: 422 HNYLLYE 428
>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
Length = 420
Score = 70.5 bits (171), Expect = 2e-12
Identities = 47/135 (34%), Positives = 72/135 (53%), Gaps = 6/135 (4%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A GDL TL SLLQ+ + +E S + GW TP+ AA G C+ L+R
Sbjct: 26 LHRACRDGDLATLCSLLQQTPHAHLASEDSFY--GW---TPVHWAAHFGKLECLVQLVRA 80
Query: 101 GAEVDLVDVK-GQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADI 159
GA +++ + QT ++A GH + L++AGA+ N TP++ A+R G +
Sbjct: 81 GATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINKPDCEGETPIHKAARSGSLEC 140
Query: 160 LKALIRYGADVDVNH 174
+ AL+ GA VD+ +
Sbjct: 141 ISALVANGAHVDLRN 155
Score = 42.0 bits (97), Expect = 8e-04
Identities = 34/93 (36%), Positives = 44/93 (47%), Gaps = 8/93 (8%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T H AA+ G Q L L+Q + IN+ C G TP+ AA +G C+ L+
Sbjct: 94 TPAHIAAFGGHPQCLVWLIQAGA---NINKPD--CEGE---TPIHKAARSGSLECISALV 145
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILL 131
GA VDL + G TA +A G E Q LL
Sbjct: 146 ANGAHVDLRNASGLTAADIAQTQGFQECAQFLL 178
Score = 33.1 bits (74), Expect = 0.36
Identities = 28/97 (28%), Positives = 44/97 (45%), Gaps = 18/97 (18%)
Query: 146 TPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNL 205
TPV+ A+ G+ + L L+R GA ++V+ T P +I+A +
Sbjct: 60 TPVHWAAHFGKLECLVQLVRAGATLNVS--------------TTRYAQTPAHIAAFGGHP 105
Query: 206 QCFRLLLLAGAN---PDFNCNGPVNTQGFYRGSPGCV 239
QC L+ AGAN PD P++ + GS C+
Sbjct: 106 QCLVWLIQAGANINKPDCEGETPIH-KAARSGSLECI 141
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/190 (30%), Positives = 89/190 (46%), Gaps = 25/190 (13%)
Query: 30 DHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
D L+H T LH AA+ G + + LL + + + N +++ TPL IA
Sbjct: 366 DITLDHL--TPLHVAAHCGHHRVAKVLLDKGA---KPNSRAL-----NGFTPLHIACKKN 415
Query: 90 HGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVY 149
H ++ L++ GA +D V G T L+VA GHL + LL+ GA PN S TP++
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 475
Query: 150 HASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFR 209
A+R G ++ K L++ A V+ D Q PL+ +A + +
Sbjct: 476 MAARAGHTEVAKYLLQNKAKVNAK---AKDDQ------------TPLHCAARIGHTNMVK 520
Query: 210 LLLLAGANPD 219
LLL ANP+
Sbjct: 521 LLLENNANPN 530
Score = 69.3 bits (168), Expect = 5e-12
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 36/201 (17%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G ++ + LL +E +K T L IAA AG V L+
Sbjct: 82 LHLASKEGHVKMVVELLHKEIILETTTKKGN--------TALHIAALAGQDEVVRELVNY 133
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA V+ KG T LY+A HLE + LLE GA+ N + TP+ A + G +++
Sbjct: 134 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 193
Query: 161 KALIRYG---------------------ADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
LI YG A V + + PDV L+ PL+I+
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV-------LSKTGFTPLHIA 246
Query: 200 AAYHNLQCFRLLLLAGANPDF 220
A Y NL +LLL GA+ +F
Sbjct: 247 AHYENLNVAQLLLNRGASVNF 267
Score = 67.8 bits (164), Expect = 1e-11
Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A+++G L +++LLQ + + N K TPL +AA AGH +L+
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE--------TPLHMAARAGHTEVAKYLL 490
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A+V+ QT L+ A GH ++LLE A+PN + TP++ A+R G +
Sbjct: 491 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 550
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ AL+ A +T PL+++A Y ++ LLL A+P
Sbjct: 551 TVLALLEKEAS---------------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 595
Query: 219 D 219
+
Sbjct: 596 N 596
Score = 67.8 bits (164), Expect = 1e-11
Identities = 54/181 (29%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA ++ RSLLQ Y N +SV TPL +AA GH V L+
Sbjct: 637 TPLHIAAKQNQVEVARSLLQ---YGGSANAESVQ-----GVTPLHLAAQEGHAEMVALLL 688
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
K A +L + G T L++ GH+ +L++ G + + TP++ AS G
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
++K L+++ ADV+ T L PL+ +A + LLL GA+P
Sbjct: 749 LVKFLLQHQADVNAK---------------TKLGYSPLHQAAQQGHTDIVTLLLKNGASP 793
Query: 219 D 219
+
Sbjct: 794 N 794
Score = 63.2 bits (152), Expect = 3e-10
Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+P+ +AA H CV L++ AE+D + + T L+VA GH ++LL+ GA PN
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ TP++ A + +++ L++ GA +D +T + PL+++
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA---------------VTESGLTPLHVA 444
Query: 200 AAYHNLQCFRLLLLAGANPD 219
+ +L + LL GA+P+
Sbjct: 445 SFMGHLPIVKNLLQRGASPN 464
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 32/202 (15%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ +L + LL + + + + TPL IA+ G+ V L+
Sbjct: 241 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--------TPLHIASRRGNVIMVRLLL 292
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GA+++ T L+ A NGH+ ++ILL+ GA + +P++ A++ D
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352
Query: 159 ILKALIRYGADVD--VNHHLTP-------------------DVQPRFSRRLTSLVVCPLY 197
++ L++Y A++D HLTP +P SR L PL+
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFT--PLH 409
Query: 198 ISAAYHNLQCFRLLLLAGANPD 219
I+ ++++ LLL GA+ D
Sbjct: 410 IACKKNHVRVMELLLKTGASID 431
Score = 58.9 bits (141), Expect = 6e-09
Identities = 66/237 (27%), Positives = 97/237 (40%), Gaps = 35/237 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+ T LH AA +G ++ LL+ + N G TPL IAA GH V
Sbjct: 503 DQTPLHCAARIGHTNMVKLLLENNA-----NPNLATTAGH---TPLHIAAREGHVETVLA 554
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ K A + KG T L+VA G + ++LLE A PN + + TP++ A
Sbjct: 555 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 614
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
DI+K L+ G P ++ PL+I+A + ++ R LL G
Sbjct: 615 LDIVKLLLPRGGSPH---------SPAWNG------YTPLHIAAKQNQVEVARSLLQYG- 658
Query: 217 NPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
G N + +P + + G A V+LL+ AN NL L P
Sbjct: 659 -------GSANAESVQGVTP---LHLAAQEG-HAEMVALLLSKQANGNLGNKSGLTP 704
Score = 56.2 bits (134), Expect = 4e-08
Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 35/241 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A + +L ++ LL S W TPL IAA L+
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ G + V+G T L++A GH E +LL A+ N TP++ ++ G
Sbjct: 656 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ LI++G VD T + PL++++ Y N++ + LL A+
Sbjct: 716 VADVLIKHGVMVDAT---------------TRMGYTPLHVASHYGNIKLVKFLLQHQAD- 759
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGR 278
VN + SP + + G V+LL++ GA+ N V + P + +
Sbjct: 760 -------VNAKTKLGYSP---LHQAAQQG-HTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808
Query: 279 R 279
R
Sbjct: 809 R 809
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A+ G+ V FL++ A+V+ G + L+ A GH + +LL+ GA PN
Sbjct: 736 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 795
Query: 140 SRHHRSTPVYHASRVGR---ADILKAL 163
+TP+ A R+G D+LK +
Sbjct: 796 VSSDGTTPLAIAKRLGYISVTDVLKVV 822
Score = 46.6 bits (109), Expect = 3e-05
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 55/228 (24%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L+ AA L+ ++ LL+ + ++ E TPL +A GH + V LI
Sbjct: 146 TPLYMAAQENHLEVVKFLLENGANQNVATEDGF--------TPLAVALQQGHENVVAHLI 197
Query: 99 RKGAE-----------------------------VDLVDVKGQTALYVAVVNGHLESTQI 129
G + D++ G T L++A +L Q+
Sbjct: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 257
Query: 130 LLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD--VNHHLTP------DVQ 181
LL GA N + + TP++ ASR G +++ L+ GA ++ LTP +
Sbjct: 258 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 317
Query: 182 PRFSRRL----------TSLVVCPLYISAAYHNLQCFRLLLLAGANPD 219
R S L T + P++++A +L C RLLL A D
Sbjct: 318 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 365
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
LR A + +D L R G +++ + G L++A GH++ LL +
Sbjct: 50 LRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 108
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
+T ++ A+ G+ ++++ L+ YGA+V+ Q F+ PLY++A
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQS------QKGFT---------PLYMAAQ 153
Query: 202 YHNLQCFRLLLLAGAN 217
++L+ + LL GAN
Sbjct: 154 ENHLEVVKFLLENGAN 169
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/190 (30%), Positives = 89/190 (46%), Gaps = 25/190 (13%)
Query: 30 DHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
D L+H T LH AA+ G + + LL + + + N +++ TPL IA
Sbjct: 333 DITLDHL--TPLHVAAHCGHHRVAKVLLDKGA---KPNSRAL-----NGFTPLHIACKKN 382
Query: 90 HGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVY 149
H ++ L++ GA +D V G T L+VA GHL + LL+ GA PN S TP++
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 150 HASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFR 209
A+R G ++ K L++ A V+ D Q PL+ +A + +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAK---AKDDQ------------TPLHCAARIGHTNMVK 487
Query: 210 LLLLAGANPD 219
LLL ANP+
Sbjct: 488 LLLENNANPN 497
Score = 69.3 bits (168), Expect = 5e-12
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 36/201 (17%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G ++ + LL +E +K T L IAA AG V L+
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGN--------TALHIAALAGQDEVVRELVNY 100
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA V+ KG T LY+A HLE + LLE GA+ N + TP+ A + G +++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 161 KALIRYG---------------------ADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
LI YG A V + + PDV L+ PL+I+
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV-------LSKTGFTPLHIA 213
Query: 200 AAYHNLQCFRLLLLAGANPDF 220
A Y NL +LLL GA+ +F
Sbjct: 214 AHYENLNVAQLLLNRGASVNF 234
Score = 67.8 bits (164), Expect = 1e-11
Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A+++G L +++LLQ + + N K TPL +AA AGH +L+
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE--------TPLHMAARAGHTEVAKYLL 457
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A+V+ QT L+ A GH ++LLE A+PN + TP++ A+R G +
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ AL+ A +T PL+++A Y ++ LLL A+P
Sbjct: 518 TVLALLEKEAS---------------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 219 D 219
+
Sbjct: 563 N 563
Score = 67.8 bits (164), Expect = 1e-11
Identities = 54/181 (29%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA ++ RSLLQ Y N +SV TPL +AA GH V L+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQ---YGGSANAESVQ-----GVTPLHLAAQEGHAEMVALLL 655
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
K A +L + G T L++ GH+ +L++ G + + TP++ AS G
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
++K L+++ ADV+ T L PL+ +A + LLL GA+P
Sbjct: 716 LVKFLLQHQADVNAK---------------TKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 219 D 219
+
Sbjct: 761 N 761
Score = 63.2 bits (152), Expect = 3e-10
Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+P+ +AA H CV L++ AE+D + + T L+VA GH ++LL+ GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ TP++ A + +++ L++ GA +D +T + PL+++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA---------------VTESGLTPLHVA 411
Query: 200 AAYHNLQCFRLLLLAGANPD 219
+ +L + LL GA+P+
Sbjct: 412 SFMGHLPIVKNLLQRGASPN 431
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 32/202 (15%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ +L + LL + + + + TPL IA+ G+ V L+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--------TPLHIASRRGNVIMVRLLL 259
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GA+++ T L+ A NGH+ ++ILL+ GA + +P++ A++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 159 ILKALIRYGADVD--VNHHLTP-------------------DVQPRFSRRLTSLVVCPLY 197
++ L++Y A++D HLTP +P SR L PL+
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFT--PLH 376
Query: 198 ISAAYHNLQCFRLLLLAGANPD 219
I+ ++++ LLL GA+ D
Sbjct: 377 IACKKNHVRVMELLLKTGASID 398
Score = 58.9 bits (141), Expect = 6e-09
Identities = 66/237 (27%), Positives = 97/237 (40%), Gaps = 35/237 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+ T LH AA +G ++ LL+ + N G TPL IAA GH V
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNA-----NPNLATTAGH---TPLHIAAREGHVETVLA 521
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ K A + KG T L+VA G + ++LLE A PN + + TP++ A
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
DI+K L+ G P ++ PL+I+A + ++ R LL G
Sbjct: 582 LDIVKLLLPRGGSPH---------SPAWNG------YTPLHIAAKQNQVEVARSLLQYG- 625
Query: 217 NPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
G N + +P + + G A V+LL+ AN NL L P
Sbjct: 626 -------GSANAESVQGVTP---LHLAAQEG-HAEMVALLLSKQANGNLGNKSGLTP 671
Score = 56.2 bits (134), Expect = 4e-08
Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 35/241 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A + +L ++ LL S W TPL IAA L+
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ G + V+G T L++A GH E +LL A+ N TP++ ++ G
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ LI++G VD T + PL++++ Y N++ + LL A+
Sbjct: 683 VADVLIKHGVMVDAT---------------TRMGYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGR 278
VN + SP + + G V+LL++ GA+ N V + P + +
Sbjct: 727 -------VNAKTKLGYSP---LHQAAQQG-HTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 279 R 279
R
Sbjct: 776 R 776
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A+ G+ V FL++ A+V+ G + L+ A GH + +LL+ GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 140 SRHHRSTPVYHASRVGR---ADILKAL 163
+TP+ A R+G D+LK +
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 46.6 bits (109), Expect = 3e-05
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 55/228 (24%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L+ AA L+ ++ LL+ + ++ E TPL +A GH + V LI
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGF--------TPLAVALQQGHENVVAHLI 164
Query: 99 RKGAE-----------------------------VDLVDVKGQTALYVAVVNGHLESTQI 129
G + D++ G T L++A +L Q+
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 130 LLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD--VNHHLTP------DVQ 181
LL GA N + + TP++ ASR G +++ L+ GA ++ LTP +
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 182 PRFSRRL----------TSLVVCPLYISAAYHNLQCFRLLLLAGANPD 219
R S L T + P++++A +L C RLLL A D
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
LR A + +D L R G +++ + G L++A GH++ LL +
Sbjct: 17 LRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
+T ++ A+ G+ ++++ L+ YGA+V+ Q F+ PLY++A
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQS------QKGFT---------PLYMAAQ 120
Query: 202 YHNLQCFRLLLLAGAN 217
++L+ + LL GAN
Sbjct: 121 ENHLEVVKFLLENGAN 136
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/190 (30%), Positives = 89/190 (46%), Gaps = 25/190 (13%)
Query: 30 DHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
D L+H T LH AA+ G + + LL + + + N +++ TPL IA
Sbjct: 333 DITLDHL--TPLHVAAHCGHHRVAKVLLDKGA---KPNSRAL-----NGFTPLHIACKKN 382
Query: 90 HGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVY 149
H ++ L++ GA +D V G T L+VA GHL + LL+ GA PN S TP++
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 150 HASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFR 209
A+R G ++ K L++ A V+ D Q PL+ +A + +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAK---AKDDQ------------TPLHCAARIGHTNMVK 487
Query: 210 LLLLAGANPD 219
LLL ANP+
Sbjct: 488 LLLENNANPN 497
Score = 69.3 bits (168), Expect = 5e-12
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 36/201 (17%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G ++ + LL +E +K T L IAA AG V L+
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGN--------TALHIAALAGQDEVVRELVNY 100
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA V+ KG T LY+A HLE + LLE GA+ N + TP+ A + G +++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 161 KALIRYG---------------------ADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
LI YG A V + + PDV L+ PL+I+
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV-------LSKTGFTPLHIA 213
Query: 200 AAYHNLQCFRLLLLAGANPDF 220
A Y NL +LLL GA+ +F
Sbjct: 214 AHYENLNVAQLLLNRGASVNF 234
Score = 67.8 bits (164), Expect = 1e-11
Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A+++G L +++LLQ + + N K TPL +AA AGH +L+
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE--------TPLHMAARAGHTEVAKYLL 457
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A+V+ QT L+ A GH ++LLE A+PN + TP++ A+R G +
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ AL+ A +T PL+++A Y ++ LLL A+P
Sbjct: 518 TVLALLEKEAS---------------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 219 D 219
+
Sbjct: 563 N 563
Score = 67.8 bits (164), Expect = 1e-11
Identities = 54/181 (29%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA ++ RSLLQ Y N +SV TPL +AA GH V L+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQ---YGGSANAESVQ-----GVTPLHLAAQEGHAEMVALLL 655
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
K A +L + G T L++ GH+ +L++ G + + TP++ AS G
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
++K L+++ ADV+ T L PL+ +A + LLL GA+P
Sbjct: 716 LVKFLLQHQADVNAK---------------TKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 219 D 219
+
Sbjct: 761 N 761
Score = 63.2 bits (152), Expect = 3e-10
Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+P+ +AA H CV L++ AE+D + + T L+VA GH ++LL+ GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ TP++ A + +++ L++ GA +D +T + PL+++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA---------------VTESGLTPLHVA 411
Query: 200 AAYHNLQCFRLLLLAGANPD 219
+ +L + LL GA+P+
Sbjct: 412 SFMGHLPIVKNLLQRGASPN 431
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 32/202 (15%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ +L + LL + + + + TPL IA+ G+ V L+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--------TPLHIASRRGNVIMVRLLL 259
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GA+++ T L+ A NGH+ ++ILL+ GA + +P++ A++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 159 ILKALIRYGADVD--VNHHLTP-------------------DVQPRFSRRLTSLVVCPLY 197
++ L++Y A++D HLTP +P SR L PL+
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFT--PLH 376
Query: 198 ISAAYHNLQCFRLLLLAGANPD 219
I+ ++++ LLL GA+ D
Sbjct: 377 IACKKNHVRVMELLLKTGASID 398
Score = 58.9 bits (141), Expect = 6e-09
Identities = 66/237 (27%), Positives = 97/237 (40%), Gaps = 35/237 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+ T LH AA +G ++ LL+ + N G TPL IAA GH V
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNA-----NPNLATTAGH---TPLHIAAREGHVETVLA 521
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ K A + KG T L+VA G + ++LLE A PN + + TP++ A
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
DI+K L+ G P ++ PL+I+A + ++ R LL G
Sbjct: 582 LDIVKLLLPRGGSPH---------SPAWNG------YTPLHIAAKQNQVEVARSLLQYG- 625
Query: 217 NPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
G N + +P + + G A V+LL+ AN NL L P
Sbjct: 626 -------GSANAESVQGVTP---LHLAAQEG-HAEMVALLLSKQANGNLGNKSGLTP 671
Score = 56.2 bits (134), Expect = 4e-08
Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 35/241 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A + +L ++ LL S W TPL IAA L+
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ G + V+G T L++A GH E +LL A+ N TP++ ++ G
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ LI++G VD T + PL++++ Y N++ + LL A+
Sbjct: 683 VADVLIKHGVMVDAT---------------TRMGYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGR 278
VN + SP + + G V+LL++ GA+ N V + P + +
Sbjct: 727 -------VNAKTKLGYSP---LHQAAQQG-HTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 279 R 279
R
Sbjct: 776 R 776
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A+ G+ V FL++ A+V+ G + L+ A GH + +LL+ GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 140 SRHHRSTPVYHASRVGR---ADILKAL 163
+TP+ A R+G D+LK +
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 46.6 bits (109), Expect = 3e-05
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 55/228 (24%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L+ AA L+ ++ LL+ + ++ E TPL +A GH + V LI
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGF--------TPLAVALQQGHENVVAHLI 164
Query: 99 RKGAE-----------------------------VDLVDVKGQTALYVAVVNGHLESTQI 129
G + D++ G T L++A +L Q+
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 130 LLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD--VNHHLTP------DVQ 181
LL GA N + + TP++ ASR G +++ L+ GA ++ LTP +
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 182 PRFSRRL----------TSLVVCPLYISAAYHNLQCFRLLLLAGANPD 219
R S L T + P++++A +L C RLLL A D
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
LR A + +D L R G +++ + G L++A GH++ LL +
Sbjct: 17 LRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
+T ++ A+ G+ ++++ L+ YGA+V+ Q F+ PLY++A
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQS------QKGFT---------PLYMAAQ 120
Query: 202 YHNLQCFRLLLLAGAN 217
++L+ + LL GAN
Sbjct: 121 ENHLEVVKFLLENGAN 136
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/190 (30%), Positives = 89/190 (46%), Gaps = 25/190 (13%)
Query: 30 DHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
D L+H T LH AA+ G + + LL + + + N +++ TPL IA
Sbjct: 333 DITLDHL--TPLHVAAHCGHHRVAKVLLDKGA---KPNSRAL-----NGFTPLHIACKKN 382
Query: 90 HGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVY 149
H ++ L++ GA +D V G T L+VA GHL + LL+ GA PN S TP++
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 150 HASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFR 209
A+R G ++ K L++ A V+ D Q PL+ +A + +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAK---AKDDQ------------TPLHCAARIGHTNMVK 487
Query: 210 LLLLAGANPD 219
LLL ANP+
Sbjct: 488 LLLENNANPN 497
Score = 69.3 bits (168), Expect = 5e-12
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 36/201 (17%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G ++ + LL +E +K T L IAA AG V L+
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGN--------TALHIAALAGQDEVVRELVNY 100
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA V+ KG T LY+A HLE + LLE GA+ N + TP+ A + G +++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 161 KALIRYG---------------------ADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
LI YG A V + + PDV L+ PL+I+
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV-------LSKTGFTPLHIA 213
Query: 200 AAYHNLQCFRLLLLAGANPDF 220
A Y NL +LLL GA+ +F
Sbjct: 214 AHYENLNVAQLLLNRGASVNF 234
Score = 67.8 bits (164), Expect = 1e-11
Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A+++G L +++LLQ + + N K TPL +AA AGH +L+
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE--------TPLHMAARAGHTEVAKYLL 457
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A+V+ QT L+ A GH ++LLE A+PN + TP++ A+R G +
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ AL+ A +T PL+++A Y ++ LLL A+P
Sbjct: 518 TVLALLEKEAS---------------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 219 D 219
+
Sbjct: 563 N 563
Score = 67.8 bits (164), Expect = 1e-11
Identities = 54/181 (29%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA ++ RSLLQ Y N +SV TPL +AA GH V L+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQ---YGGSANAESVQ-----GVTPLHLAAQEGHAEMVALLL 655
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
K A +L + G T L++ GH+ +L++ G + + TP++ AS G
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
++K L+++ ADV+ T L PL+ +A + LLL GA+P
Sbjct: 716 LVKFLLQHQADVNAK---------------TKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 219 D 219
+
Sbjct: 761 N 761
Score = 63.2 bits (152), Expect = 3e-10
Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+P+ +AA H CV L++ AE+D + + T L+VA GH ++LL+ GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ TP++ A + +++ L++ GA +D +T + PL+++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA---------------VTESGLTPLHVA 411
Query: 200 AAYHNLQCFRLLLLAGANPD 219
+ +L + LL GA+P+
Sbjct: 412 SFMGHLPIVKNLLQRGASPN 431
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 32/202 (15%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ +L + LL + + + + TPL IA+ G+ V L+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--------TPLHIASRRGNVIMVRLLL 259
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GA+++ T L+ A NGH+ ++ILL+ GA + +P++ A++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 159 ILKALIRYGADVD--VNHHLTP-------------------DVQPRFSRRLTSLVVCPLY 197
++ L++Y A++D HLTP +P SR L PL+
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFT--PLH 376
Query: 198 ISAAYHNLQCFRLLLLAGANPD 219
I+ ++++ LLL GA+ D
Sbjct: 377 IACKKNHVRVMELLLKTGASID 398
Score = 58.9 bits (141), Expect = 6e-09
Identities = 66/237 (27%), Positives = 97/237 (40%), Gaps = 35/237 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+ T LH AA +G ++ LL+ + N G TPL IAA GH V
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNA-----NPNLATTAGH---TPLHIAAREGHVETVLA 521
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ K A + KG T L+VA G + ++LLE A PN + + TP++ A
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
DI+K L+ G P ++ PL+I+A + ++ R LL G
Sbjct: 582 LDIVKLLLPRGGSPH---------SPAWNG------YTPLHIAAKQNQVEVARSLLQYG- 625
Query: 217 NPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
G N + +P + + G A V+LL+ AN NL L P
Sbjct: 626 -------GSANAESVQGVTP---LHLAAQEG-HAEMVALLLSKQANGNLGNKSGLTP 671
Score = 56.2 bits (134), Expect = 4e-08
Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 35/241 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A + +L ++ LL S W TPL IAA L+
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ G + V+G T L++A GH E +LL A+ N TP++ ++ G
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ LI++G VD T + PL++++ Y N++ + LL A+
Sbjct: 683 VADVLIKHGVMVDAT---------------TRMGYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGR 278
VN + SP + + G V+LL++ GA+ N V + P + +
Sbjct: 727 -------VNAKTKLGYSP---LHQAAQQG-HTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 279 R 279
R
Sbjct: 776 R 776
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A+ G+ V FL++ A+V+ G + L+ A GH + +LL+ GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 140 SRHHRSTPVYHASRVGR---ADILKAL 163
+TP+ A R+G D+LK +
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 46.6 bits (109), Expect = 3e-05
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 55/228 (24%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L+ AA L+ ++ LL+ + ++ E TPL +A GH + V LI
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGF--------TPLAVALQQGHENVVAHLI 164
Query: 99 RKGAE-----------------------------VDLVDVKGQTALYVAVVNGHLESTQI 129
G + D++ G T L++A +L Q+
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 130 LLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD--VNHHLTP------DVQ 181
LL GA N + + TP++ ASR G +++ L+ GA ++ LTP +
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 182 PRFSRRL----------TSLVVCPLYISAAYHNLQCFRLLLLAGANPD 219
R S L T + P++++A +L C RLLL A D
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
LR A + +D L R G +++ + G L++A GH++ LL +
Sbjct: 17 LRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
+T ++ A+ G+ ++++ L+ YGA+V+ Q F+ PLY++A
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQS------QKGFT---------PLYMAAQ 120
Query: 202 YHNLQCFRLLLLAGAN 217
++L+ + LL GAN
Sbjct: 121 ENHLEVVKFLLENGAN 136
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 69.7 bits (169), Expect = 3e-12
Identities = 58/190 (30%), Positives = 89/190 (46%), Gaps = 25/190 (13%)
Query: 30 DHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG 89
D L+H T LH AA+ G + + LL + + + N +++ TPL IA
Sbjct: 333 DITLDHL--TPLHVAAHCGHHRVAKVLLDKGA---KPNSRAL-----NGFTPLHIACKKN 382
Query: 90 HGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVY 149
H ++ L++ GA +D V G T L+VA GHL + LL+ GA PN S TP++
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLH 442
Query: 150 HASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFR 209
A+R G ++ K L++ A V+ D Q PL+ +A + +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAK---AKDDQ------------TPLHCAARIGHTNMVK 487
Query: 210 LLLLAGANPD 219
LLL ANP+
Sbjct: 488 LLLENNANPN 497
Score = 69.3 bits (168), Expect = 5e-12
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 36/201 (17%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRK 100
LH A+ G ++ + LL +E +K T L IAA AG V L+
Sbjct: 49 LHLASKEGHVKMVVELLHKEIILETTTKKGN--------TALHIAALAGQDEVVRELVNY 100
Query: 101 GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADIL 160
GA V+ KG T LY+A HLE + LLE GA+ N + TP+ A + G +++
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 161 KALIRYG---------------------ADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
LI YG A V + + PDV L+ PL+I+
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV-------LSKTGFTPLHIA 213
Query: 200 AAYHNLQCFRLLLLAGANPDF 220
A Y NL +LLL GA+ +F
Sbjct: 214 AHYENLNVAQLLLNRGASVNF 234
Score = 67.8 bits (164), Expect = 1e-11
Identities = 52/181 (28%), Positives = 85/181 (46%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A+++G L +++LLQ + + N K TPL +AA AGH +L+
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE--------TPLHMAARAGHTEVAKYLL 457
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A+V+ QT L+ A GH ++LLE A+PN + TP++ A+R G +
Sbjct: 458 QNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVE 517
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ AL+ A +T PL+++A Y ++ LLL A+P
Sbjct: 518 TVLALLEKEAS---------------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 219 D 219
+
Sbjct: 563 N 563
Score = 67.8 bits (164), Expect = 1e-11
Identities = 54/181 (29%), Positives = 82/181 (45%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA ++ RSLLQ Y N +SV TPL +AA GH V L+
Sbjct: 604 TPLHIAAKQNQVEVARSLLQ---YGGSANAESVQ-----GVTPLHLAAQEGHAEMVALLL 655
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
K A +L + G T L++ GH+ +L++ G + + TP++ AS G
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
++K L+++ ADV+ T L PL+ +A + LLL GA+P
Sbjct: 716 LVKFLLQHQADVNAK---------------TKLGYSPLHQAAQQGHTDIVTLLLKNGASP 760
Query: 219 D 219
+
Sbjct: 761 N 761
Score = 63.2 bits (152), Expect = 3e-10
Identities = 38/140 (27%), Positives = 70/140 (50%), Gaps = 15/140 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+P+ +AA H CV L++ AE+D + + T L+VA GH ++LL+ GA PN
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
+ TP++ A + +++ L++ GA +D +T + PL+++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDA---------------VTESGLTPLHVA 411
Query: 200 AAYHNLQCFRLLLLAGANPD 219
+ +L + LL GA+P+
Sbjct: 412 SFMGHLPIVKNLLQRGASPN 431
Score = 61.6 bits (148), Expect = 9e-10
Identities = 53/202 (26%), Positives = 92/202 (45%), Gaps = 32/202 (15%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ +L + LL + + + + TPL IA+ G+ V L+
Sbjct: 208 TPLHIAAHYENLNVAQLLLNRGASVNFTPQNGI--------TPLHIASRRGNVIMVRLLL 259
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+GA+++ T L+ A NGH+ ++ILL+ GA + +P++ A++ D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 159 ILKALIRYGADVD--VNHHLTP-------------------DVQPRFSRRLTSLVVCPLY 197
++ L++Y A++D HLTP +P SR L PL+
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRALNGFT--PLH 376
Query: 198 ISAAYHNLQCFRLLLLAGANPD 219
I+ ++++ LLL GA+ D
Sbjct: 377 IACKKNHVRVMELLLKTGASID 398
Score = 58.9 bits (141), Expect = 6e-09
Identities = 66/237 (27%), Positives = 97/237 (40%), Gaps = 35/237 (14%)
Query: 37 EDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDF 96
+ T LH AA +G ++ LL+ + N G TPL IAA GH V
Sbjct: 470 DQTPLHCAARIGHTNMVKLLLENNA-----NPNLATTAGH---TPLHIAAREGHVETVLA 521
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ K A + KG T L+VA G + ++LLE A PN + + TP++ A
Sbjct: 522 LLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNN 581
Query: 157 ADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGA 216
DI+K L+ G P ++ PL+I+A + ++ R LL G
Sbjct: 582 LDIVKLLLPRGGSPH---------SPAWNG------YTPLHIAAKQNQVEVARSLLQYG- 625
Query: 217 NPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGP 273
G N + +P + + G A V+LL+ AN NL L P
Sbjct: 626 -------GSANAESVQGVTP---LHLAAQEG-HAEMVALLLSKQANGNLGNKSGLTP 671
Score = 56.2 bits (134), Expect = 4e-08
Identities = 59/241 (24%), Positives = 97/241 (40%), Gaps = 35/241 (14%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A + +L ++ LL S W TPL IAA L+
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGG--------SPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ G + V+G T L++A GH E +LL A+ N TP++ ++ G
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ LI++G VD T + PL++++ Y N++ + LL A+
Sbjct: 683 VADVLIKHGVMVDAT---------------TRMGYTPLHVASHYGNIKLVKFLLQHQAD- 726
Query: 219 DFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGR 278
VN + SP + + G V+LL++ GA+ N V + P + +
Sbjct: 727 -------VNAKTKLGYSP---LHQAAQQG-HTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Query: 279 R 279
R
Sbjct: 776 R 776
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/87 (33%), Positives = 46/87 (52%), Gaps = 3/87 (3%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +A+ G+ V FL++ A+V+ G + L+ A GH + +LL+ GA PN
Sbjct: 703 TPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE 762
Query: 140 SRHHRSTPVYHASRVGR---ADILKAL 163
+TP+ A R+G D+LK +
Sbjct: 763 VSSDGTTPLAIAKRLGYISVTDVLKVV 789
Score = 46.6 bits (109), Expect = 3e-05
Identities = 56/228 (24%), Positives = 90/228 (39%), Gaps = 55/228 (24%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L+ AA L+ ++ LL+ + ++ E TPL +A GH + V LI
Sbjct: 113 TPLYMAAQENHLEVVKFLLENGANQNVATEDGF--------TPLAVALQQGHENVVAHLI 164
Query: 99 RKGAE-----------------------------VDLVDVKGQTALYVAVVNGHLESTQI 129
G + D++ G T L++A +L Q+
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQL 224
Query: 130 LLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVD--VNHHLTP------DVQ 181
LL GA N + + TP++ ASR G +++ L+ GA ++ LTP +
Sbjct: 225 LLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGH 284
Query: 182 PRFSRRL----------TSLVVCPLYISAAYHNLQCFRLLLLAGANPD 219
R S L T + P++++A +L C RLLL A D
Sbjct: 285 VRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEID 332
Score = 43.9 bits (102), Expect = 2e-04
Identities = 34/136 (25%), Positives = 64/136 (47%), Gaps = 16/136 (11%)
Query: 82 LRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSR 141
LR A + +D L R G +++ + G L++A GH++ LL +
Sbjct: 17 LRAARSGNLDKALDHL-RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 142 HHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA 201
+T ++ A+ G+ ++++ L+ YGA+V+ Q F+ PLY++A
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQS------QKGFT---------PLYMAAQ 120
Query: 202 YHNLQCFRLLLLAGAN 217
++L+ + LL GAN
Sbjct: 121 ENHLEVVKFLLENGAN 136
>gi|7657265 fem-1 homolog b [Homo sapiens]
Length = 627
Score = 69.3 bits (168), Expect = 5e-12
Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 9/141 (6%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T L AA G + ++ L+ S+ + +N +V TPLR A G V +L+
Sbjct: 90 TALWCAAGAGHFEVVKLLV---SHGANVNHTTV-----TNSTPLRAACFDGRLDIVKYLV 141
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
A + + + T L +A GH + + LLE ADPN H +T ++ A+ G D
Sbjct: 142 ENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQRADPNAKAHCGATALHFAAEAGHID 201
Query: 159 ILKALIRYGADVDVN-HHLTP 178
I+K LI++ A + VN H +TP
Sbjct: 202 IVKELIKWRAAIVVNGHGMTP 222
Score = 50.8 bits (120), Expect = 2e-06
Identities = 45/142 (31%), Positives = 63/142 (44%), Gaps = 10/142 (7%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRS-RINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIR 99
++ AA G + TL +LL S R V G TPL IAA GH V L+
Sbjct: 8 VYKAASEGKVLTLAALLLNRSESDIRYLLGYVSQQGGQRSTPLIIAARNGHAKVVRLLLE 67
Query: 100 K---------GAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYH 150
D + G TAL+ A GH E ++L+ GA+ N + STP+
Sbjct: 68 HYRVQTQQTGTVRFDGYVIDGATALWCAAGAGHFEVVKLLVSHGANVNHTTVTNSTPLRA 127
Query: 151 ASRVGRADILKALIRYGADVDV 172
A GR DI+K L+ A++ +
Sbjct: 128 ACFDGRLDIVKYLVENNANISI 149
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 68.9 bits (167), Expect = 6e-12
Identities = 48/144 (33%), Positives = 70/144 (48%), Gaps = 8/144 (5%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A Y + + + SLL + ++ G+ T L IA AGH D L+
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQV--------GYGGLTALHIATIAGHLEAADVLL 154
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA V++ D T L++A GH + T++LL+ GAD N S P++ AS G +
Sbjct: 155 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 214
Query: 159 ILKALIRYGADVDVNHHLTPDVQP 182
I K L+ G+ DVN D P
Sbjct: 215 IAKLLMEEGSKADVNAQDNEDHVP 238
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/147 (27%), Positives = 67/147 (45%), Gaps = 17/147 (11%)
Query: 89 GHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPV 148
G S + L+ KG + G TAL++AV + E LL +GAD + T +
Sbjct: 79 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138
Query: 149 YHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCF 208
+ A+ G + L+++GA+V++ ++ PL+I+A Y + Q
Sbjct: 139 HIATIAGHLEAADVLLQHGANVNIQ---------------DAVFFTPLHIAAYYGHEQVT 183
Query: 209 RLLLLAGANPDFNCNGPVNTQGFYRGS 235
RLLL GA D N +G V + + S
Sbjct: 184 RLLLKFGA--DVNVSGEVGDRPLHLAS 208
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/145 (24%), Positives = 68/145 (46%), Gaps = 18/145 (12%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEES---YRSRINEKSVWCCGWLPCTPLRIAATAGHGSCV 94
D LH A+ G L + L++E S ++ NE V PL + GH V
Sbjct: 201 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV---------PLHFCSRFGHHDIV 251
Query: 95 DFLIRKGAEVD--LVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHH--RSTPVYH 150
+L++ EV +V++ G T L++A NG E + +++ + ++ + T +
Sbjct: 252 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHS 311
Query: 151 ASRVGRA-DILKALIRYGADVDVNH 174
A G++ D++K L+ +++NH
Sbjct: 312 ACTYGKSIDLVKFLLDQNV-ININH 335
Score = 36.6 bits (83), Expect = 0.032
Identities = 30/110 (27%), Positives = 44/110 (40%), Gaps = 22/110 (20%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSC---- 93
DT LH A Y G + + ++Q S E + TA H +C
Sbjct: 271 DTPLHLACYNGKFEVAKEIIQISGTESLTKENI-------------FSETAFHSACTYGK 317
Query: 94 ----VDFLIRKGA-EVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPN 138
V FL+ + ++ G T L+ A +GH+ Q LL+ GAD N
Sbjct: 318 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 68.9 bits (167), Expect = 6e-12
Identities = 48/144 (33%), Positives = 70/144 (48%), Gaps = 8/144 (5%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A Y + + + SLL + ++ G+ T L IA AGH D L+
Sbjct: 204 TALHLAVYKDNAELITSLLHSGADIQQV--------GYGGLTALHIATIAGHLEAADVLL 255
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA V++ D T L++A GH + T++LL+ GAD N S P++ AS G +
Sbjct: 256 QHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLN 315
Query: 159 ILKALIRYGADVDVNHHLTPDVQP 182
I K L+ G+ DVN D P
Sbjct: 316 IAKLLMEEGSKADVNAQDNEDHVP 339
Score = 47.8 bits (112), Expect = 1e-05
Identities = 41/147 (27%), Positives = 67/147 (45%), Gaps = 17/147 (11%)
Query: 89 GHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPV 148
G S + L+ KG + G TAL++AV + E LL +GAD + T +
Sbjct: 180 GKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 239
Query: 149 YHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCF 208
+ A+ G + L+++GA+V++ ++ PL+I+A Y + Q
Sbjct: 240 HIATIAGHLEAADVLLQHGANVNIQ---------------DAVFFTPLHIAAYYGHEQVT 284
Query: 209 RLLLLAGANPDFNCNGPVNTQGFYRGS 235
RLLL GA D N +G V + + S
Sbjct: 285 RLLLKFGA--DVNVSGEVGDRPLHLAS 309
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/145 (24%), Positives = 68/145 (46%), Gaps = 18/145 (12%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEES---YRSRINEKSVWCCGWLPCTPLRIAATAGHGSCV 94
D LH A+ G L + L++E S ++ NE V PL + GH V
Sbjct: 302 DRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHV---------PLHFCSRFGHHDIV 352
Query: 95 DFLIRKGAEVD--LVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHH--RSTPVYH 150
+L++ EV +V++ G T L++A NG E + +++ + ++ + T +
Sbjct: 353 KYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHS 412
Query: 151 ASRVGRA-DILKALIRYGADVDVNH 174
A G++ D++K L+ +++NH
Sbjct: 413 ACTYGKSIDLVKFLLDQNV-ININH 436
Score = 36.6 bits (83), Expect = 0.032
Identities = 30/110 (27%), Positives = 44/110 (40%), Gaps = 22/110 (20%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSC---- 93
DT LH A Y G + + ++Q S E + TA H +C
Sbjct: 372 DTPLHLACYNGKFEVAKEIIQISGTESLTKENI-------------FSETAFHSACTYGK 418
Query: 94 ----VDFLIRKGA-EVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPN 138
V FL+ + ++ G T L+ A +GH+ Q LL+ GAD N
Sbjct: 419 SIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 68.6 bits (166), Expect = 8e-12
Identities = 60/203 (29%), Positives = 98/203 (48%), Gaps = 29/203 (14%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGS-CVDF 96
+T LH A Y G + L+ + ++ NEK TPL AA + HG+ C++
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGF--------TPLHFAAASTHGALCLEL 291
Query: 97 LIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
L+ GA+V++ G+T L++ ++G +Q ++++GA + + +TP++ A+R G
Sbjct: 292 LVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Query: 157 ADILKALIRYGADVDVN--HHLTPDVQPRFS------RRLTSL---VVCP-------LYI 198
++ LI GAD H + P S R+L S + P L+
Sbjct: 352 ELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHA 411
Query: 199 SAAYHNLQCFRLLLLAGANPDFN 221
+AA NL+C LLL GA DFN
Sbjct: 412 AAAGGNLECLNLLLNTGA--DFN 432
Score = 63.2 bits (152), Expect = 3e-10
Identities = 43/135 (31%), Positives = 65/135 (48%), Gaps = 5/135 (3%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T +H AA G + LR L+ ++ ++ + TPL ++ GH CV L+
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQD-----GNGQTPLMLSVLNGHTDCVYSLL 673
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
KGA VD D G+TAL+ V GH E LL+ GA TP++ ++ G
Sbjct: 674 NKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG 733
Query: 159 ILKALIRYGADVDVN 173
+L AL++ A +D N
Sbjct: 734 VLGALLQSAASMDAN 748
Score = 57.4 bits (137), Expect = 2e-08
Identities = 51/180 (28%), Positives = 80/180 (44%), Gaps = 24/180 (13%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ G + ++ LL + + ++K W AA GH V L+
Sbjct: 142 TALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHW--------AAYMGHIEVVKLLV 193
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
GAEV D K T L+ A +G + + LL+ G D N + +TP++ A G+
Sbjct: 194 SHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDV 253
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAA-YHNLQCFRLLLLAGAN 217
++ LI GA V+ + + F+ PL+ +AA H C LL+ GA+
Sbjct: 254 VVNELIDCGAIVNQKN------EKGFT---------PLHFAAASTHGALCLELLVGNGAD 298
Score = 57.0 bits (136), Expect = 2e-08
Identities = 39/133 (29%), Positives = 68/133 (51%), Gaps = 8/133 (6%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AAY+GD + + L+ + R+N K WL TPL A + V L+
Sbjct: 43 TPLHAAAYLGDAEIIELLILSGA---RVNAKD---SKWL--TPLHRAVASCSEEAVQVLL 94
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ A+V+ D QT L++A N ++ + L+ ++ N S T ++HA+ G +
Sbjct: 95 KHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGE 154
Query: 159 ILKALIRYGADVD 171
++K L+ GA+++
Sbjct: 155 MVKLLLSRGANIN 167
Score = 56.6 bits (135), Expect = 3e-08
Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 12/140 (8%)
Query: 36 CED----TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHG 91
CED T LH AA G + +L+ + ++ ++ PL +AA +G
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMF--------PLHLAALSGFS 385
Query: 92 SCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHA 151
C L+ G ++D D G+T L+ A G+LE +LL GAD N +P+++A
Sbjct: 386 DCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYA 445
Query: 152 SRVGRADILKALIRYGADVD 171
+ L AL+ GA V+
Sbjct: 446 AANCNYQCLFALVGSGASVN 465
Score = 52.8 bits (125), Expect = 4e-07
Identities = 46/173 (26%), Positives = 78/173 (45%), Gaps = 16/173 (9%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
+PL +AA GH ++ L++ ++D+ + G+T L +A GH+E +L+ GA
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 140 SRH-HRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYI 198
+ + TP++ A+ G ++ L+ LI + D+Q + PL +
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLLIG-----NAEPQNAVDIQDGNGQ-------TPLML 659
Query: 199 SAAYHNLQCFRLLLLAGANPDF--NCNGPVNTQGFYRGSPGCVMDAVLRHGCE 249
S + C LL GAN D +G G CV DA+L+HG +
Sbjct: 660 SVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECV-DALLQHGAK 711
Score = 52.4 bits (124), Expect = 6e-07
Identities = 41/134 (30%), Positives = 66/134 (49%), Gaps = 10/134 (7%)
Query: 41 LHDAAYVGDLQTLRSLL-QEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIR 99
L A + GD +R+L+ ++E + NEK TPL AA G ++ LI
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKR---------TPLHAAAYLGDAEIIELLIL 62
Query: 100 KGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADI 159
GA V+ D K T L+ AV + E+ Q+LL+ AD N + TP++ A+
Sbjct: 63 SGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKC 122
Query: 160 LKALIRYGADVDVN 173
+AL+ ++V+V+
Sbjct: 123 AEALVPLLSNVNVS 136
Score = 52.0 bits (123), Expect = 7e-07
Identities = 40/138 (28%), Positives = 65/138 (47%), Gaps = 15/138 (10%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL IAA GH ++ LI GA+ + G L++A ++G + + LL +G D +
Sbjct: 341 TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT 400
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
T ++ A+ G + L L+ GAD + + +F R PL+ +
Sbjct: 401 PDDFGRTCLHAAAAGGNLECLNLLLNTGADFNK--------KDKFGRS-------PLHYA 445
Query: 200 AAYHNLQCFRLLLLAGAN 217
AA N QC L+ +GA+
Sbjct: 446 AANCNYQCLFALVGSGAS 463
Score = 51.2 bits (121), Expect = 1e-06
Identities = 45/136 (33%), Positives = 70/136 (51%), Gaps = 12/136 (8%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AA+ ++ L+ LL S+ +++N SV G TPL +AA G + V+ L+
Sbjct: 825 TPLHAAAFTDHVECLQLLL---SHNAQVN--SVDSTGK---TPLMMAAENGQTNTVEMLV 876
Query: 99 RKG-AEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADP---NGSRHHRSTPVYHASRV 154
AE+ L D TAL++A GH S ++LE D N + TP++ A+R
Sbjct: 877 SSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARN 936
Query: 155 GRADILKALIRYGADV 170
G +++ L+ GA V
Sbjct: 937 GLTMVVQELLGKGASV 952
Score = 45.8 bits (107), Expect = 5e-05
Identities = 46/190 (24%), Positives = 85/190 (44%), Gaps = 36/190 (18%)
Query: 41 LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAG-HGSCVDFLIR 99
LH AA + Q L +L+ + + ++E+ CTPL AAT+ G C+++L+R
Sbjct: 442 LHYAAANCNYQCLFALVGSGASVNDLDERG--------CTPLHYAATSDTDGKCLEYLLR 493
Query: 100 KGAEVDLVDVKGQTALYVAVVNGHLESTQILLE----------AGADPNGSRHHRST--P 147
A + D +G A++ + GH Q++ +G D +R+T P
Sbjct: 494 NDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISP 553
Query: 148 VYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQC 207
++ A+ G L+ L++ D+DV + S PL ++A +++C
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRN---------------SSGRTPLDLAAFKGHVEC 598
Query: 208 FRLLLLAGAN 217
+L+ GA+
Sbjct: 599 VDVLINQGAS 608
Score = 43.5 bits (101), Expect = 3e-04
Identities = 55/207 (26%), Positives = 89/207 (42%), Gaps = 31/207 (14%)
Query: 36 CED----TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHG 91
C+D T LH AA G + ++ LL +NE + + TPL +A G
Sbjct: 201 CKDKKSYTPLHAAASSGMISVVKYLLD---LGVDMNEPNAY-----GNTPLHVACYNGQD 252
Query: 92 SCVDFLIRKGAEVDLVDVKGQTALYVAVVNGH-LESTQILLEAGADPNGSRHHRSTPVYH 150
V+ LI GA V+ + KG T L+ A + H ++L+ GAD N TP++
Sbjct: 253 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHM 312
Query: 151 ASRVGRADILKALIRYGADVDV---NHHLTPDVQPRFSRRL--TSLV------------- 192
+ GR + +I+ GA +D N + + R+ L +L+
Sbjct: 313 TALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHG 372
Query: 193 VCPLYISAAYHNLQCFRLLLLAGANPD 219
+ PL+++A C R LL +G + D
Sbjct: 373 MFPLHLAALSGFSDCCRKLLSSGFDID 399
Score = 42.4 bits (98), Expect = 6e-04
Identities = 36/128 (28%), Positives = 58/128 (45%), Gaps = 11/128 (8%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A Y G + LL++E ++ E + + +PL A + + LI
Sbjct: 758 TALHWACYNGHETCVELLLEQEVFQK--TEGNAF-------SPLHCAVINDNEGAAEMLI 808
Query: 99 RK-GAE-VDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGR 156
GA V+ D KG+T L+ A H+E Q+LL A N TP+ A+ G+
Sbjct: 809 DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQ 868
Query: 157 ADILKALI 164
+ ++ L+
Sbjct: 869 TNTVEMLV 876
Score = 38.5 bits (88), Expect = 0.009
Identities = 21/73 (28%), Positives = 38/73 (52%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
T L AA G+ C++ L+ GA+ + D G++ L+ A N + + L+ +GA N
Sbjct: 407 TCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVND 466
Query: 140 SRHHRSTPVYHAS 152
TP+++A+
Sbjct: 467 LDERGCTPLHYAA 479
Score = 37.0 bits (84), Expect = 0.025
Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 12/98 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH A G + + +LLQ + + + TP+ ++A GH + L+
Sbjct: 688 TALHRGAVTGHEECVDALLQHGAKCLLRDSRGR--------TPIHLSAACGHIGVLGALL 739
Query: 99 RKGAEVDL----VDVKGQTALYVAVVNGHLESTQILLE 132
+ A +D D G TAL+ A NGH ++LLE
Sbjct: 740 QSAASMDANPATADNHGYTALHWACYNGHETCVELLLE 777
Score = 36.6 bits (83), Expect = 0.032
Identities = 46/181 (25%), Positives = 72/181 (39%), Gaps = 44/181 (24%)
Query: 109 VKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGA 168
++ Q +L A+ NG + + L+ D N + + TP++ A+ +G A+I++ LI GA
Sbjct: 6 LRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGA 65
Query: 169 DVDV--NHHLTP---------------------DVQPRFSRRLTSLVVCPLYISAAYHNL 205
V+ + LTP DV R T PL+I+AA +
Sbjct: 66 RVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQT-----PLHIAAANKAV 120
Query: 206 QCFRLL--LLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANL 263
+C L LL+ N + G HG V LL+ GAN+
Sbjct: 121 KCAEALVPLLSNVNVSDRAGRTALHHAAFSG-----------HG---EMVKLLLSRGANI 166
Query: 264 N 264
N
Sbjct: 167 N 167
Score = 33.1 bits (74), Expect = 0.36
Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 5/118 (4%)
Query: 34 EHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSC 93
++ ++T LH A G + +L++ + R+ IN + TPL +AA G
Sbjct: 887 DNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ-----TPLHVAARNGLTMV 941
Query: 94 VDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHA 151
V L+ KGA V VD G T N + L+ A P S S+ ++A
Sbjct: 942 VQELLGKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNA 999
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 67.8 bits (164), Expect = 1e-11
Identities = 59/194 (30%), Positives = 90/194 (46%), Gaps = 27/194 (13%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +AA GH S V L +GAE+D +T L++AV G + + Q LL++GA P+
Sbjct: 496 TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDA 555
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYIS 199
P++ A+ G+ I K L+RYGA +++ H PL+++
Sbjct: 556 LDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQG---------------WTPLHLA 600
Query: 200 AAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEF 259
A +L+ LL + AN G VN + + RHG E A VS L++
Sbjct: 601 AYKGHLEIIHLLAESHAN--MGALGAVNWTPLHLAA---------RHG-EEAVVSALLQC 648
Query: 260 GANLNLVKWESLGP 273
GA+ N + P
Sbjct: 649 GADPNAAEQSGWTP 662
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/134 (32%), Positives = 64/134 (47%), Gaps = 8/134 (5%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH AAY G L+ + L + S N ++ W TPL +AA G + V L+
Sbjct: 595 TPLHLAAYKGHLEIIHLLAE-----SHANMGALGAVNW---TPLHLAARHGEEAVVSALL 646
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
+ GA+ + + G T L++AV S LLE A+ + TP + A+ G
Sbjct: 647 QCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTA 706
Query: 159 ILKALIRYGADVDV 172
ILK L+ GA +DV
Sbjct: 707 ILKVLVEAGAQLDV 720
Score = 54.3 bits (129), Expect = 2e-07
Identities = 41/145 (28%), Positives = 64/145 (44%), Gaps = 18/145 (12%)
Query: 75 GWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAG 134
GW PL AA G L+ GA VD + +G T L++A N ++L+
Sbjct: 428 GW---APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484
Query: 135 ADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVC 194
ADPN TP++ A+ G ++K L GA++D R L +
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQ-----------QRNLRT---- 529
Query: 195 PLYISAAYHNLQCFRLLLLAGANPD 219
PL+++ ++ + LL +GA PD
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPD 554
Score = 45.1 bits (105), Expect = 9e-05
Identities = 45/181 (24%), Positives = 76/181 (41%), Gaps = 23/181 (12%)
Query: 39 TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLI 98
T LH G ++ +R LL +E V C TPL IAA L+
Sbjct: 364 TPLHFLVAQGSVEQVRLLLA--------HEVDVDCQTASGYTPLLIAAQDQQPDLCALLL 415
Query: 99 RKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRAD 158
GA+ + VD G L+ A NG + ++LL+ GA + TP++ A++ +
Sbjct: 416 AHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN 475
Query: 159 ILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
+ + L+ AD P++ + PL+++A + ++ +LL GA
Sbjct: 476 VARLLVSRQAD--------PNLHEAEGK-------TPLHVAAYFGHVSLVKLLTSQGAEL 520
Query: 219 D 219
D
Sbjct: 521 D 521
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 67.8 bits (164), Expect = 1e-11
Identities = 43/132 (32%), Positives = 68/132 (51%), Gaps = 7/132 (5%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFL 97
D RL +A+ GDL+T++ L ++ R E TPL AA S V++L
Sbjct: 651 DYRLLEASKAGDLETVKQLCSSQNVNCRDLEGR-------HSTPLHFAAGYNRVSVVEYL 703
Query: 98 IRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRA 157
+ GA+V D G L+ A GH E ++L+ GA N + + TP++ A+ G+
Sbjct: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
Query: 158 DILKALIRYGAD 169
+I K L+++GAD
Sbjct: 764 EICKLLLKHGAD 775
Score = 62.8 bits (151), Expect = 4e-10
Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 21/166 (12%)
Query: 9 GRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINE 68
G AGPG+ + LRE LE C + GD+ ++ L+ + +N
Sbjct: 168 GAAGPGTGVPAVSGALREL-----LEACRN---------GDVSRVKRLVDA----ANVNA 209
Query: 69 KSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQ 128
K + +PL AA G V+ L++ GA V D G L+ A GH E
Sbjct: 210 KDM---AGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVS 266
Query: 129 ILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNH 174
+LL GADPN + TP++ A+ G+ D+ L+++GAD ++ +
Sbjct: 267 LLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN 312
Score = 55.1 bits (131), Expect = 9e-08
Identities = 38/121 (31%), Positives = 63/121 (52%), Gaps = 9/121 (7%)
Query: 20 LKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYR--SRINEKSVWCCGWL 77
+K+ L + + +T LH A V L R + E R + +NEK+
Sbjct: 505 VKKTLALEIINFKQPQSHETALHCA--VASLHPKRKQVTELLLRKGANVNEKNKDFM--- 559
Query: 78 PCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADP 137
TPL +AA H ++ L + GA+++ +D GQTAL+ A + GHL++ ++LL G+DP
Sbjct: 560 --TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDP 617
Query: 138 N 138
+
Sbjct: 618 S 618
Score = 54.3 bits (129), Expect = 2e-07
Identities = 39/115 (33%), Positives = 55/115 (47%), Gaps = 5/115 (4%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
TPL +AA V L++ GA+V D G L+ A GH E T++LL+ GA N
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
Query: 140 SRHHRSTPVYHASRVGRADILKALIRYGADVD-VNHHLTPDVQ----PRFSRRLT 189
+ TP++ A+ R ++ L+ +GAD VN H V P RLT
Sbjct: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLT 485
Score = 53.5 bits (127), Expect = 3e-07
Identities = 58/208 (27%), Positives = 90/208 (43%), Gaps = 28/208 (13%)
Query: 26 EQFCDHPLEHCED------TRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPC 79
+Q C +C D T LH AA + + LL + + ++ K G L
Sbjct: 667 KQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH---HGADVHAKDK---GGL-- 718
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
PL A + GH + L+R GA V++ D+ T L+ A G E ++LL+ GADP
Sbjct: 719 VPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTK 778
Query: 140 SRHHRSTPVYHASRVGRADILKAL---------IRYGADVDVNHHLTPD-VQPRFSRRLT 189
+TP+ + G DI L + G V TP+ + R ++
Sbjct: 779 KNRDGNTPL-DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRN 837
Query: 190 SLVVCPLYISAAYHNLQCFRLLLLAGAN 217
S PL+++A Y+NL+ LL GA+
Sbjct: 838 S---TPLHLAAGYNNLEVAEYLLEHGAD 862
Score = 52.4 bits (124), Expect = 6e-07
Identities = 36/132 (27%), Positives = 61/132 (46%), Gaps = 7/132 (5%)
Query: 38 DTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFL 97
D L DAA G L ++ L E+ R + TPL +AA + ++L
Sbjct: 804 DAALLDAAKKGCLARVQKLCTPENINCRDTQGR-------NSTPLHLAAGYNNLEVAEYL 856
Query: 98 IRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRA 157
+ GA+V+ D G L+ A GH++ +L++ N + TP++ A++ GR
Sbjct: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916
Query: 158 DILKALIRYGAD 169
+ L+ +GAD
Sbjct: 917 QLCALLLAHGAD 928
Score = 43.5 bits (101), Expect = 3e-04
Identities = 66/249 (26%), Positives = 100/249 (40%), Gaps = 49/249 (19%)
Query: 33 LEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGW---------LPCTPLR 83
L+ T LH AA G LQT R LL S S I+ + TP+R
Sbjct: 587 LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIR 646
Query: 84 I---------AATAGHGSCVDFLIRKGAEVDLVDVKGQ--TALYVAVVNGHLESTQILLE 132
A+ AG V L V+ D++G+ T L+ A + + LL
Sbjct: 647 TSDVDYRLLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705
Query: 133 AGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLV 192
GAD + P+++A G ++ + L+R+GA V+V D+ +F+
Sbjct: 706 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-----ADLW-KFT------- 752
Query: 193 VCPLYISAAYHNLQCFRLLLLAGANP-----------DFNCNGPVNTQGFYRGSPGCVMD 241
PL+ +AA + +LLL GA+P D G + Q RG ++D
Sbjct: 753 --PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGD-AALLD 809
Query: 242 AVLRHGCEA 250
A + GC A
Sbjct: 810 AA-KKGCLA 817
Score = 40.8 bits (94), Expect = 0.002
Identities = 31/109 (28%), Positives = 45/109 (41%), Gaps = 15/109 (13%)
Query: 110 KGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGAD 169
+ T L++A +LE + LLE GAD N P+++A+ G DI LI+Y
Sbjct: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
Query: 170 VDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANP 218
V+ PL+ +A Q LLL GA+P
Sbjct: 896 VNAT---------------DKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
Score = 39.7 bits (91), Expect = 0.004
Identities = 45/186 (24%), Positives = 82/186 (44%), Gaps = 42/186 (22%)
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVA------VVNGHLESTQILLEA 133
TPL AA G L++ GA+ ++ + G++AL +A V+ G + + LLEA
Sbjct: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDE-LLEA 342
Query: 134 GADPN----------------GSRHHRSTPVYHASRVGRADILKALIRYGADV------- 170
N S +STP++ A+ R I++ L+++GADV
Sbjct: 343 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
Query: 171 --------DVNHHLTPDVQPRFSRRLTSLVV---CPLYISAAYHNLQCFRLLLLAGANPD 219
H+ ++ + + ++ + PL+ +A+ + ++ LLL GA+P
Sbjct: 403 LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPT 462
Query: 220 F-NCNG 224
NC+G
Sbjct: 463 LVNCHG 468
Score = 39.7 bits (91), Expect = 0.004
Identities = 38/155 (24%), Positives = 64/155 (41%), Gaps = 17/155 (10%)
Query: 20 LKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEE--SYRSRINEKSVWCCGWL 77
L+E L +F H L AA DL ++ L E +++ + ++ C
Sbjct: 480 LRERLTYEFKGHSLLQ--------AAREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531
Query: 78 PCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADP 137
P R T + L+RKGA V+ + T L+VA H + ++L + GA
Sbjct: 532 SLHPKRKQVT-------ELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKM 584
Query: 138 NGSRHHRSTPVYHASRVGRADILKALIRYGADVDV 172
N T ++ A+ G + L+ YG+D +
Sbjct: 585 NALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
Score = 39.3 bits (90), Expect = 0.005
Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 18/145 (12%)
Query: 26 EQFCDHPLEHCEDTR------LHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPC 79
++ C +C DT+ LH AA +L+ LL+ + + +N + G L
Sbjct: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLE---HGADVNAQDK---GGL-- 871
Query: 80 TPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNG 139
PL AA+ GH LI+ V+ D T L+ A G + +LL GADP
Sbjct: 872 IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM 931
Query: 140 SRHHRSTPVYHASRVGRADILKALI 164
TP+ A+ AD ++AL+
Sbjct: 932 KNQEGQTPLDLAT----ADDIRALL 952
Score = 33.1 bits (74), Expect = 0.36
Identities = 32/139 (23%), Positives = 64/139 (46%), Gaps = 21/139 (15%)
Query: 115 LYVAVVNGHLESTQILLEAG-ADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVN 173
L A NG + + L++A + +S+P++ A+ GR D+++ L++ GA+V
Sbjct: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV--- 242
Query: 174 HHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCN---GPVNTQG 230
H D + PL+ + ++ + + LLL GA+P+ N P++
Sbjct: 243 -HARDDGG-----------LIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAA 290
Query: 231 FYRGSPGCVMDAVLRHGCE 249
C++ +L+HG +
Sbjct: 291 IKGKIDVCIV--LLQHGAD 307
>gi|21389427 GA repeat binding protein, beta 2 [Homo sapiens]
Length = 448
Score = 66.6 bits (161), Expect = 3e-11
Identities = 35/113 (30%), Positives = 60/113 (53%)
Query: 58 QEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYV 117
Q++ R+ + + + WL +PL +AA GH S + L+R G D +T L++
Sbjct: 18 QDDEVRTLMANGAPFTTDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVDRTPLHM 77
Query: 118 AVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADV 170
A +GH ++L+ GAD N + T ++ A+ D+++ LI+YGADV
Sbjct: 78 AAADGHAHIVELLVRNGADVNAKDMLKMTALHWATERHHRDVVELLIKYGADV 130
Score = 45.4 bits (106), Expect = 7e-05
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 1/92 (1%)
Query: 85 AATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHR 144
AA G V L+ GA D G + L++A GH + ++LL AG +
Sbjct: 13 AARKGQDDEVRTLMANGAPFT-TDWLGTSPLHLAAQYGHYSTAEVLLRAGVSRDARTKVD 71
Query: 145 STPVYHASRVGRADILKALIRYGADVDVNHHL 176
TP++ A+ G A I++ L+R GADV+ L
Sbjct: 72 RTPLHMAAADGHAHIVELLVRNGADVNAKDML 103
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,071,190
Number of Sequences: 37866
Number of extensions: 620841
Number of successful extensions: 3853
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 330
Number of HSP's successfully gapped in prelim test: 39
Number of HSP's that attempted gapping in prelim test: 1456
Number of HSP's gapped (non-prelim): 1450
length of query: 335
length of database: 18,247,518
effective HSP length: 103
effective length of query: 232
effective length of database: 14,347,320
effective search space: 3328578240
effective search space used: 3328578240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.