Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 94680976
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94680976 coiled-coil domain containing 112 isoform 1 [Homo
sapiens]
(529 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94680976 coiled-coil domain containing 112 isoform 1 [Homo sa... 1054 0.0
gi|145580595 coiled-coil domain containing 112 isoform 2 [Homo s... 893 0.0
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 95 1e-19
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 92 2e-18
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 87 3e-17
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 87 3e-17
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 9e-16
gi|148746195 trichohyalin [Homo sapiens] 79 1e-14
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 78 2e-14
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 78 2e-14
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 77 3e-14
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 75 2e-13
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 72 1e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 71 3e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 71 3e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 71 3e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 71 3e-12
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 70 5e-12
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 70 5e-12
gi|55770834 centromere protein F [Homo sapiens] 70 5e-12
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 69 8e-12
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 69 8e-12
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 69 8e-12
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 69 8e-12
gi|46049114 M-phase phosphoprotein 1 [Homo sapiens] 69 1e-11
gi|31377611 coiled-coil domain containing 148 [Homo sapiens] 68 2e-11
gi|38044112 restin isoform b [Homo sapiens] 68 2e-11
gi|4506751 restin isoform a [Homo sapiens] 68 2e-11
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 67 4e-11
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 66 7e-11
>gi|94680976 coiled-coil domain containing 112 isoform 1 [Homo
sapiens]
Length = 529
Score = 1054 bits (2726), Expect = 0.0
Identities = 529/529 (100%), Positives = 529/529 (100%)
Query: 1 MAALTTVVVAAAATAVAGAVAGAGAATGTGVGATPAPQQSDGCFSTSGGIRPFHLQNWKQ 60
MAALTTVVVAAAATAVAGAVAGAGAATGTGVGATPAPQQSDGCFSTSGGIRPFHLQNWKQ
Sbjct: 1 MAALTTVVVAAAATAVAGAVAGAGAATGTGVGATPAPQQSDGCFSTSGGIRPFHLQNWKQ 60
Query: 61 KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE
Sbjct: 61 KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
Query: 121 RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEEL 180
RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEEL
Sbjct: 121 RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEEL 180
Query: 181 IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFL 240
IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFL
Sbjct: 181 IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFL 240
Query: 241 QQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLAL 300
QQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLAL
Sbjct: 241 QQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLAL 300
Query: 301 EERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEA 360
EERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEA
Sbjct: 301 EERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEA 360
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE 420
WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE
Sbjct: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE 420
Query: 421 IREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN 480
IREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN
Sbjct: 421 IREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN 480
Query: 481 VSRDPSRLYKPTKGWEERTKKIGPTGSGPLLHIPHRAIPTWRQGIQRRV 529
VSRDPSRLYKPTKGWEERTKKIGPTGSGPLLHIPHRAIPTWRQGIQRRV
Sbjct: 481 VSRDPSRLYKPTKGWEERTKKIGPTGSGPLLHIPHRAIPTWRQGIQRRV 529
>gi|145580595 coiled-coil domain containing 112 isoform 2 [Homo
sapiens]
Length = 446
Score = 893 bits (2307), Expect = 0.0
Identities = 446/446 (100%), Positives = 446/446 (100%)
Query: 84 MEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLK 143
MEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLK
Sbjct: 1 MEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLK 60
Query: 144 DVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWAL 203
DVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWAL
Sbjct: 61 DVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWAL 120
Query: 204 GNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRN 263
GNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRN
Sbjct: 121 GNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRN 180
Query: 264 KHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIF 323
KHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIF
Sbjct: 181 KHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIF 240
Query: 324 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK 383
KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK
Sbjct: 241 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK 300
Query: 384 EKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQE 443
EKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQE
Sbjct: 301 EKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQE 360
Query: 444 RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG 503
RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG
Sbjct: 361 RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG 420
Query: 504 PTGSGPLLHIPHRAIPTWRQGIQRRV 529
PTGSGPLLHIPHRAIPTWRQGIQRRV
Sbjct: 421 PTGSGPLLHIPHRAIPTWRQGIQRRV 446
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 95.1 bits (235), Expect = 1e-19
Identities = 97/448 (21%), Positives = 211/448 (47%), Gaps = 54/448 (12%)
Query: 89 HSHFYNQKSDFRIEHSMLEELENKL--IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVK 146
HS QK+ + + ++ ELE ++ I ++ ++Q L + VK+L+ + +D+
Sbjct: 105 HSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 164
Query: 147 PTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNS 206
K +E+ +A+ T K++ EEL KE + EL + + N+
Sbjct: 165 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224
Query: 207 ETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHK 266
+ ++ + + S+ ++ L + L+ K L Q ++ H
Sbjct: 225 KLQEKLQLVESEKSEIQLNVKELKRK-LERAKLLLP-------------QQQLQAEADHL 270
Query: 267 GKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEE---RKKESIQIWKTKKQQKREEIF 323
GK L+ + K Q +V+++E W + EE R++E IQ W+ K Q++ E+I
Sbjct: 271 GKE------LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR 324
Query: 324 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE-----------AWKKQKSI---EM 369
+ +EK ++E +++E+ R+++++ E W+K++ I E
Sbjct: 325 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEE 384
Query: 370 SMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKK--EQEEFLR-LEKEIREKAE 426
M +++E+EEK ++ +K R+++ + + + + Q++K EQEE +R EK++ + E
Sbjct: 385 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 444
Query: 427 KAEKRKNAADEISRFQERDLHKLELKILDRQA--KEDEKSQKQRRLAKLKEKV------- 477
K +++ +E R ++ ++ + E KI +++ ++ EK +Q ++ K +EKV
Sbjct: 445 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKM 504
Query: 478 ---ENNVSRDPSRLYKPTKGWEERTKKI 502
E + ++++ + E+ +KI
Sbjct: 505 HDQEEKIREQEEKMWRQEEKIREQEEKI 532
Score = 84.7 bits (208), Expect = 2e-16
Identities = 99/455 (21%), Positives = 217/455 (47%), Gaps = 59/455 (12%)
Query: 57 NWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
N K+ + ++A+ + ++ + + ++ K+ S + K ++E + EL N+L
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQS--VSAKLQAQVEEN---ELWNRL--- 294
Query: 117 RKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLI 176
+ + K+ +Q KI +K+Q Q EK+RE E+I + ++ ++
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQ----------EEKIREQEEKIREQEEKMRRQEEMM 344
Query: 177 YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDF 236
+E KEEK E W E E+ R + + + L E++ +
Sbjct: 345 WE---KEEKMRRQEEMM-------W-----EKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 237 EKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ----QHEK 292
EK +Q RQ + + R + + K EE + K +++ + Q EK
Sbjct: 390 EKIREQEEKRQEEEKIREQEK----RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEK 445
Query: 293 WY-QKFLALEERKKESIQIWKTKKQ-QKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQ 350
+ Q+ + EE+++E ++W+ +++ +++EEI++ KEK H +++ +++++
Sbjct: 446 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK-------MHEQEKIRKQEEKVW 498
Query: 351 RKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK-EKKHQKERQRQFKLKLLLESYTQQK- 408
R+++K+ + K ++ E + +++E+EEK ++ +K R+++ ++ E +Q+
Sbjct: 499 RQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEE 558
Query: 409 --KEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQK 466
+EQE+ R E++IRE+ EK ++K E R QE + + E KI +++ E+ +K
Sbjct: 559 KMQEQEKMRRQEEKIREQEEKIREQK----EKIREQEEKIWEQEEKIREQEEMMQEQEEK 614
Query: 467 Q-RRLAKLKEKVENNVSRDPSRLYKPTKGWEERTK 500
+ K+ E+ E ++ + K WE+ +
Sbjct: 615 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 649
Score = 59.7 bits (143), Expect = 6e-09
Identities = 78/370 (21%), Positives = 168/370 (45%), Gaps = 51/370 (13%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLE------- 107
+Q W++K+ Q ++ + EK + Q M + + + ++ R E M E
Sbjct: 309 IQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 108 -------------ELENKLIHSRKT-ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVE 153
ELE K+ K E+ + +Q+ KI K+ + + K + E
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE----E 423
Query: 154 KLREMMEEI-ENAINTFKEEQRLIYEELIKEE--KTTNNELSAISRKIDTWALGNSETEK 210
K+RE E+I E +++E+++ +E I+EE + E+ KI + EK
Sbjct: 424 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 483
Query: 211 AFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPT 270
+ +KV E++ D E+ +++ + ++ + K+R + + K
Sbjct: 484 MHEQEKIRKQEEKVWRQE--EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE-KIR 540
Query: 271 FMEEVL---EHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKE 327
EE++ E G+ ++++Q+ EK ++ + E++ E I+ K K +++ E+I++ +E
Sbjct: 541 EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE-EKIREQKEKIREQEEKIWEQEE 599
Query: 328 KADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQ--------LKE 379
K ++E Q+Q+E+ ++++ E +K + E M+ + L++
Sbjct: 600 K-------IREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQ 652
Query: 380 EEEKEKKHQK 389
+EEK ++HQ+
Sbjct: 653 QEEKMQEHQE 662
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 91.7 bits (226), Expect = 2e-18
Identities = 90/436 (20%), Positives = 206/436 (47%), Gaps = 50/436 (11%)
Query: 89 HSHFYNQKSDFRIEHSMLEELENKL--IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVK 146
HS QK+ + + ++ ELE ++ I ++ ++Q L + VK+L+ + +D+
Sbjct: 166 HSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 225
Query: 147 PTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNS 206
K +E+ +A+ T K++ EEL KE + EL + + N+
Sbjct: 226 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 285
Query: 207 ETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHK 266
+ ++ + + S+ ++ L + L+ K L Q ++ H
Sbjct: 286 KLQEKLQLVESEKSEIQLNVKELKRK-LERAKLLLP-------------QQQLQAEADHL 331
Query: 267 GKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEE---RKKESIQIWKTKKQQKREEIF 323
GK L+ + K Q +V+++E W + EE R++E IQ W+ K Q++ E+I
Sbjct: 332 GKE------LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR 385
Query: 324 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE-----------AWKKQKSI---EM 369
+ +EK ++E +++E+ R+++++ E W+K++ I E
Sbjct: 386 EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 445
Query: 370 SMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAE 429
M +++E+EEK ++ +K R+++ + + + + Q++K +E+ E++IRE+ EK
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ----EEKIREQEEKMW 501
Query: 430 KRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKV---ENNVSRDPS 486
+++ E + +E + + + + +++EK ++Q + + KEK+ E + +
Sbjct: 502 RQEEKIHEQEKIREEEKRQEQ----EEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEE 557
Query: 487 RLYKPTKGWEERTKKI 502
++++ + ++ +KI
Sbjct: 558 KMWRQEEKMHDQEEKI 573
Score = 85.9 bits (211), Expect = 8e-17
Identities = 85/423 (20%), Positives = 207/423 (48%), Gaps = 42/423 (9%)
Query: 57 NWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
N K+ + ++A+ + ++ + + ++ K+ S + K ++E + EL N+L
Sbjct: 304 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQS--VSAKLQAQVEEN---ELWNRLNQQ 358
Query: 117 RKT----ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEE 172
++ + KIQ+ KI +K++ Q + ++ + + + EMM E E + + +
Sbjct: 359 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM---RRQ 415
Query: 173 QRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKV----PVDKVTPST 228
+ +++E KEEK E W E E+ R + K+ + +
Sbjct: 416 EEMMWE---KEEKMRRQEEMM-------W-----EKEEKIRELEEKMHEQEKIREQEEKR 460
Query: 229 LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
EE + ++ Q+ + ++ + K+R + + E++ E + +++ Q
Sbjct: 461 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQ 520
Query: 289 QHEKWYQKFLALEERKKESIQIWKTKKQ--QKREEIFKLKEKADNTPVLFHNKQEDNQKQ 346
+ E+ +++ EE+ +E +IW+ K++ ++ E+I K +EK H+++E ++Q
Sbjct: 521 EQEEMWRQ----EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576
Query: 347 KEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQ 406
+E+ ++++ E +K + E ++ ++ +E+E++ Q+E+ + + K + E +
Sbjct: 577 EEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK-MQEQEEK 635
Query: 407 QKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQK 466
++++E+ EK+IRE+ EK ++ +E+ + QE + + E K+ +++ K E+ +K
Sbjct: 636 MRRQEEKIREQEKKIREQEEKIREQ----EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEK 691
Query: 467 QRR 469
RR
Sbjct: 692 MRR 694
Score = 75.1 bits (183), Expect = 1e-13
Identities = 94/451 (20%), Positives = 206/451 (45%), Gaps = 45/451 (9%)
Query: 62 VNQTKKAEFVRTAEKFKNQVINME-KDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
+ + K + E ++N + + E K+K++ + E S ++ +L RK E
Sbjct: 256 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL--KRKLE 313
Query: 121 RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIE--NAINTFKEEQRLIYE 178
RAK+ ++ L +L+ V KL+ +EE E N +N +EE+ E
Sbjct: 314 RAKLLLPQQQLQAEADHLGKELQSVSA------KLQAQVEENELWNRLNQQQEEKMWRQE 367
Query: 179 ELIKE--EKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDF 236
E I+E EK E KI E E+ R ++ +K EE++ +
Sbjct: 368 EKIQEWEEKIQEQE-----EKIREQEEKIREQEEKMRR-QEEMMWEKEEKMRRQEEMM-W 420
Query: 237 EKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQK 296
EK + + W+ + K+R + K E++ E + ++E + ++ Q+
Sbjct: 421 EKEEKMRRQEEMMWEKEE-----KIRELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQE 474
Query: 297 FLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKL 356
A R++E I+ + K +++ E++++ +EK + ++ Q++ Q +K +
Sbjct: 475 QEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE 534
Query: 357 AVEAWKKQKSIEMSMKCASQLKEEEEK-----EKKHQKERQRQFKLKLLLESYTQQKKEQ 411
E W++++ I + +++++EEK EK H +E + + E + +++
Sbjct: 535 QEEIWRQKEKIHEQEE---KIRKQEEKMWRQEEKMHDQEEK-------IREQEEKVWRQE 584
Query: 412 EEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLA 471
E+ E++IRE+ EK ++ +E+++ QE + + E K+ +++ K E+ +K RR
Sbjct: 585 EKIREQEEKIREQEEKIREQ----EEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQE 640
Query: 472 KLKEKVENNVSRDPSRLYKPTKGWEERTKKI 502
+ + E + ++ + + +E+ +K+
Sbjct: 641 EKIREQEKKIREQEEKIREQEEMMQEQEEKM 671
Score = 58.5 bits (140), Expect = 1e-08
Identities = 73/385 (18%), Positives = 173/385 (44%), Gaps = 45/385 (11%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLI 114
+Q W++K+ Q ++ + EK + Q M + + + ++ R + M+ E E K+
Sbjct: 370 IQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEM-MWEKEEKMRRQEEMMWEKEEKMR 427
Query: 115 HSRKT---ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKE 171
+ + KI++ K+H Q ++++ + EK+RE + E +++
Sbjct: 428 RQEEMMWEKEEKIRELEEKMHE-----QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 482
Query: 172 EQRLI-YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLP 230
E+++ EE I+E++ EK +R +K+
Sbjct: 483 EEKIREQEEKIREQE-----------------------EKMWRQEEKIHEQEKIREEEKR 519
Query: 231 EEVLDFEKFLQQTGGRQGAWDDYD--HQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
+E + + ++ ++ W + H+ K+R K + K EE + K +++ +
Sbjct: 520 QEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIR-KQEEKMWRQEEKMHDQEEKIREQEE 578
Query: 289 QHEKWYQKFLALEER---KKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQK 345
+ + +K EE+ ++E I+ + Q++ E++ + +EK ++E ++
Sbjct: 579 KVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRR 638
Query: 346 QKEEQRKKQKLAVEAWKK-QKSIEMSMKCASQLKEEEEK----EKKHQKERQRQFKLKLL 400
Q+E+ R+++K E +K ++ EM + ++ E+EEK E+K Q++ ++ + +
Sbjct: 639 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 698
Query: 401 LESYTQQKKEQEEFLRLEKEIREKA 425
+ + ++QEE ++ +E E A
Sbjct: 699 MWEQEVRLRQQEEKMQEHQEHLEAA 723
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 87.4 bits (215), Expect = 3e-17
Identities = 90/455 (19%), Positives = 213/455 (46%), Gaps = 33/455 (7%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLI 114
+Q W++K+ Q ++ + EK + Q M + + + ++ R E M E
Sbjct: 309 IQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE------- 360
Query: 115 HSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQR 174
K E+ + Q+++ + Q ++ K EK+RE+ E++ ++E++
Sbjct: 361 ---KEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-----EKIRELEEKMHEQEKIREQEEK 412
Query: 175 LIYEELIKEEKTTNNELSAISR---KIDTWALGNSETEKAFRAISSKV-PVDKVTPSTLP 230
EE I+E++ + + + R KI E EK K+ +K+
Sbjct: 413 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 472
Query: 231 EEVLDFEKFLQQTGGRQGAWDDYD--HQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
+E + + ++ ++ W + H+ K+R K + K EE + K ++ Q
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIR-KQEEKVWRQEEKIREQEEKIRE--Q 529
Query: 289 QHEKWYQKFLALEERKKESIQIWK-TKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQK 347
+ + W Q EE+ +E ++W+ +K ++E+I++ +++ + ++ +++ ++++
Sbjct: 530 EEKMWRQ-----EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEE 584
Query: 348 EEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK-EKKHQKERQRQFKLKLLLESYTQ 406
+ R+++K+ + K+Q+ E K +++E+EEK +++ +K R+++ K++ E +
Sbjct: 585 KVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE 644
Query: 407 QKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQK 466
Q+++ E E EK ++ E+ +E R QE+ + + E KI +++ E+ +K
Sbjct: 645 QEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 704
Query: 467 Q-RRLAKLKEKVENNVSRDPSRLYKPTKGWEERTK 500
+ K+ E+ E ++ + K WE+ +
Sbjct: 705 MWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVR 739
Score = 79.7 bits (195), Expect = 6e-15
Identities = 96/474 (20%), Positives = 220/474 (46%), Gaps = 53/474 (11%)
Query: 57 NWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
N K+ + ++A+ + ++ + + ++ K+ S + K ++E + EL N+L
Sbjct: 243 NVKELKRKLERAKLLLPQQQLQAEADHLGKELQS--VSAKLQAQVEEN---ELWNRLNQQ 297
Query: 117 RKT----ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTF--- 169
++ + KIQ+ KI +K++ Q + ++ + + + EMM E E +
Sbjct: 298 QEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM 357
Query: 170 ---KEEQRLIYEELI--KEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKV----P 220
KEE+ EE++ KEEK E W E E+ R + K+
Sbjct: 358 MWEKEEKMRRQEEMMWEKEEKMRRQEEMM-------W-----EKEEKIRELEEKMHEQEK 405
Query: 221 VDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLP 280
+ + EE + ++ Q+ + ++ + K+R + K E++ E
Sbjct: 406 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Query: 281 GKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQ--QKREEIFKLKEKADNTPVLFHN 338
+ +++ Q+ E+ +++ EE+ E +IW+ K++ ++ E+I K +EK
Sbjct: 466 IREEEKRQEQEEMWRQ----EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIRE 521
Query: 339 KQEDNQKQKEE---QRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQF 395
++E ++Q+E+ Q +K + E W++++ + K + EEE+++++ K +++
Sbjct: 522 QEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK----IWEEEKRQEQEDKMWRQEE 577
Query: 396 KLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILD 455
K++ E +Q+++ E +E EK K E++ +E + QE + + E KI +
Sbjct: 578 KIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIRE 637
Query: 456 R----QAKEDEKSQKQRRLAKLKEKV---ENNVSRDPSRLYKPTKGWEERTKKI 502
+ Q +E++ +++ ++ + +EK+ E + R ++ + K E+ +KI
Sbjct: 638 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI 691
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 87.4 bits (215), Expect = 3e-17
Identities = 88/419 (21%), Positives = 194/419 (46%), Gaps = 26/419 (6%)
Query: 89 HSHFYNQKSDFRIEHSMLEELENKL--IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVK 146
HS QK+ + + ++ ELE ++ I ++ ++Q L + VK+L+ + +D+
Sbjct: 93 HSPEDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 152
Query: 147 PTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNS 206
K +E+ +A+ T K++ EEL KE + EL + + N+
Sbjct: 153 SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 212
Query: 207 ETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHK 266
+ ++ + + S+ ++ L + L+ K L Q ++ H
Sbjct: 213 KLQEKLQLVESEKSEIQLNVKELKRK-LERAKLLLP-------------QQQLQAEADHL 258
Query: 267 GKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEE---RKKESIQIWKTKKQQKREEIF 323
GK L+ + K Q +V+++E W + EE R++E IQ + K Q++ E+I
Sbjct: 259 GKE------LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIR 312
Query: 324 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK 383
+ +EK + K+E ++Q+E +K++ E +K E ++ + ++EEEK
Sbjct: 313 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE-KIREQEEKRQEEEK 371
Query: 384 EKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQE 443
++ +K ++++ K+ E +Q+++ E + +E EK + E++ +E + QE
Sbjct: 372 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQE 431
Query: 444 RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKI 502
+ + E KI +++ K E+ +K R ++ ++ E + ++ + +E+ +K+
Sbjct: 432 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKM 490
Score = 75.1 bits (183), Expect = 1e-13
Identities = 87/411 (21%), Positives = 188/411 (45%), Gaps = 48/411 (11%)
Query: 62 VNQTKKAEFVRTAEKFKNQVINME-KDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
+ + K + E ++N + + E K+K++ + E S ++ +L RK E
Sbjct: 183 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKEL--KRKLE 240
Query: 121 RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIE--NAINTFKEEQRLIYE 178
RAK+ ++ L +L+ V KL+ +EE E N +N +EE+ E
Sbjct: 241 RAKLLLPQQQLQAEADHLGKELQSVSA------KLQAQVEENELWNRLNQQQEEKMWRQE 294
Query: 179 ELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEK 238
E I+E + E R+ + EK R +E + +EK
Sbjct: 295 EKIQEREEKIQEQEEKIRE---------QEEKMRR-----------------QEEMMWEK 328
Query: 239 FLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFL 298
+ + W+ + K+R + K E++ E + ++E + ++ Q+
Sbjct: 329 EEKMRRQEEMMWEKEE-----KIRELEE-KMHEQEKIREQEEKRQEEEKIREQEKRQEQE 382
Query: 299 ALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAV 358
A R++E I+ + K +++ E + + +EK ++E+ Q+Q+E+ R++++
Sbjct: 383 AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 359 EAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLE 418
E KK + E ++ ++ +E+E++ Q+ + + + K + E + ++++E+ E
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAK-MQEQEEKMRRQEEKIREQE 501
Query: 419 KEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRR 469
K+IRE+ EK ++ +E+ + QE + + E K+ +++ K E+ +K RR
Sbjct: 502 KKIREQEEKIREQ----EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 548
Score = 44.3 bits (103), Expect = 3e-04
Identities = 53/287 (18%), Positives = 120/287 (41%), Gaps = 26/287 (9%)
Query: 58 WKQKVN-QTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLE------ELE 110
W+Q+ Q ++ + EK + Q M + + + ++ R E M E ELE
Sbjct: 291 WRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 350
Query: 111 NKLIHSRKT-ERAKIQQQLAKIHNNVKKLQHQLK------DVKPTPDFVEKLREMMEEIE 163
K+ K E+ + +Q+ KI K+ + + K ++ + + + EMM+E E
Sbjct: 351 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQE 410
Query: 164 NAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK 223
+ +E+ EE+ ++E+ + I E EK R K+ +
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKI-----------REQEKKIREQEEKIREQE 459
Query: 224 VTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKT 283
E++ + E + + + ++ + K+R + K K EE +
Sbjct: 460 EMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK-KIREQEEKIREQEEMM 518
Query: 284 QDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKAD 330
Q++ ++ + +K EE+ +E + + ++++ RE+ +L+++ +
Sbjct: 519 QEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEE 565
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 82.4 bits (202), Expect = 9e-16
Identities = 98/466 (21%), Positives = 209/466 (44%), Gaps = 50/466 (10%)
Query: 64 QTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS------- 116
Q ++ + EK + Q M + + + Q+ R + + + E ++
Sbjct: 351 QEQEEKMWEQEEKMREQEEKMWRQEE-RLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409
Query: 117 --RKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQR 174
R E+ K+ +Q+ K+ KK+Q Q K T D EK++E E I +EE+
Sbjct: 410 EERMREQEKMWEQVEKMREE-KKMQEQ---EKKTRDQEEKMQEE-ERIREREKKMREEEE 464
Query: 175 LIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVL 234
+ E+ EEK E + ++ W +K K+ + E++
Sbjct: 465 TMREQ---EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 521
Query: 235 DFEKFLQQTGG--RQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEK 292
D E+ Q RQ + + Q + + K + + M + E + KTQ+ Q+ +
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQ-EEKMRDQEQKMWDQEERMEKKTQE--QEKKT 578
Query: 293 WYQKF-LALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR 351
W Q+ + EER +E + + +++ RE+ K++E+ + E +K +E++
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE 638
Query: 352 KKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL----LLESYTQQ 407
K + + W++++ + + Q ++ E EK ++E+ ++ + K+ +E TQ+
Sbjct: 639 KMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQE 698
Query: 408 KKEQ---EEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQA------ 458
++++ +E +R E+ +RE+ EK+ +E+ R QE + + E K+ +++
Sbjct: 699 QEKKTWDQEKMREEESMRER----EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE 754
Query: 459 ----KEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTK 500
+++EK +Q+RL + KEK+ + ++ + K WE+ K
Sbjct: 755 EKMWEQEEKMWEQQRLPEQKEKLWEH-----EKMQEQEKIWEQEEK 795
Score = 75.9 bits (185), Expect = 9e-14
Identities = 88/467 (18%), Positives = 210/467 (44%), Gaps = 47/467 (10%)
Query: 58 WKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKS----DFRIEHSMLEELENKL 113
W+Q +K E +R EK QV M ++K +K+ + E + E E K+
Sbjct: 400 WEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKM 459
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQ 173
+T R + ++++ K N+ + + + + P+ EKL E + E +++E+
Sbjct: 460 REEEETMREQ-EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Query: 174 RLI-YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEE 232
++ EE+ +EK + ++ W E E+ R K + ++
Sbjct: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMW-----EQEEKMRDQEQK----------MWDQ 563
Query: 233 VLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEK 292
EK Q+ + WD + + + + K EE++ K Q++ ++ ++
Sbjct: 564 EERMEKKTQEQ--EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQE 621
Query: 293 WYQKFLALEERKKESIQ-IWKTKKQ--QKREEIFKLKEKADNTPVLF-HNKQEDNQKQKE 348
+K EE+ +E + +W+ +++ ++ E++++ + + L+ H K ++ +K +E
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681
Query: 349 EQ----------RKKQKLAVEAWKKQKSIEM-SMKCASQLKEEEEKEKKHQKERQRQFKL 397
++ +K Q+ + W ++K E SM+ + EEE+ + Q+E+ ++ +
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 398 KLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQ 457
K+ ++++EE E+++ E+ EK +++ ++ + E + + + KI +++
Sbjct: 742 KM--------QEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 458 AKEDEKSQKQR-RLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG 503
K ++ +K R + K++ + E ++ + K W + K G
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840
Score = 71.6 bits (174), Expect = 2e-12
Identities = 86/451 (19%), Positives = 208/451 (46%), Gaps = 30/451 (6%)
Query: 75 EKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNN 134
E + Q M+K + + + ++ ++ + L E + KL E+ K+Q+Q KI
Sbjct: 464 ETMREQEEKMQKQEENMWEQEEKEW--QQQRLPEQKEKL-----WEQEKMQEQEEKIWEQ 516
Query: 135 VKKL--QHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNN--- 189
+K+ Q ++ + EK+RE +++ +++++ ++++ + EK T
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEK 576
Query: 190 ------ELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQT 243
E ++ E E+ R K+ + E++ + E+ +Q+
Sbjct: 577 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ 636
Query: 244 GGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEK--WYQKFLALE 301
+ ++ + K+ + + P E++ EH + Q+++Q+ E+ W Q+ + +
Sbjct: 637 EEKMWEQEEKMWEQEEKMWEQQR-LPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 302 ERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAW 361
+++E + W +K ++ E + + ++K + ++E Q+Q+E+ +++++ E
Sbjct: 696 TQEQEK-KTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQE 754
Query: 362 KKQKSIEMSMKCASQLKEEEEKEKKHQK--ERQRQFKLKLLLESYTQQKKEQEEFLRLEK 419
+K E M +L E++EK +H+K E+++ ++ + + ++ + QEE +R ++
Sbjct: 755 EKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQE 814
Query: 420 EIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
E K E++ +E QE + E K+ ++ K +EK Q Q K++E+ E
Sbjct: 815 E---KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEE--KMREQ-EE 868
Query: 480 NVSRDPSRLYKPTKGWEERTKKIGPTGSGPL 510
+ ++ + + + +KI GS P+
Sbjct: 869 KMRGQEEKMREQEEKMRGQEEKIYCVGSPPI 899
Score = 67.8 bits (164), Expect = 2e-11
Identities = 99/450 (22%), Positives = 192/450 (42%), Gaps = 63/450 (14%)
Query: 103 HSMLEEL--ENKLIHSRKTERAKIQQQLAKIHNNV-----KKLQHQLKDVKPT------P 149
H M+ E +NKL ++K Q +A + KK+ H T P
Sbjct: 10 HPMMSEKTRQNKLAEAKKKFTDYRQWNIAGVGTGATDTKKKKINHGTNPETTTSGGCHSP 69
Query: 150 DFVEKLREMMEEIENAINTFKEEQRLIYE---ELIKEEKTTNNELSAI-------SRKID 199
+ ++ R ++E + A + +E R E I+ EL +RK +
Sbjct: 70 EDTQQNRAQLKEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAARKFE 129
Query: 200 TWALG-----NSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYD 254
LG N +AFR P+ V+ S +P E D L + G
Sbjct: 130 DGNLGTPSSFNLALSQAFRGS----PLGCVSTSLIPGESKDLAGRLHHSWHFAGELQ--- 182
Query: 255 HQNFVKVRNKHKGKPTFMEEVLEHLPGK---------TQDEVQQHEKWYQKFLALEERKK 305
+ V +HK ++EE+ + T +E+++ Q+ L L E +K
Sbjct: 183 -RALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEK 241
Query: 306 ESIQIWKTKKQQKREEI-FKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQ---------K 355
IQ+ + ++K E F L + NT +QE+ +++E++ +KQ +
Sbjct: 242 SEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEER 301
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL 415
L + K ++ E + +L+E+E++ ++ +KE + Q K L E Q ++++E+
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQ---KELREQEEQMQEQEEKMW 358
Query: 416 RLEKEIREKAEK---AEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAK 472
E+++RE+ EK E+R ++ R QE+ + E ++ ++ + EK ++ R K
Sbjct: 359 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK 418
Query: 473 LKEKVENNVSRDPSRLYKPTKGWEERTKKI 502
+ E+VE R+ ++ + K ++ +K+
Sbjct: 419 MWEQVEK--MREEKKMQEQEKKTRDQEEKM 446
Score = 67.8 bits (164), Expect = 2e-11
Identities = 62/340 (18%), Positives = 161/340 (47%), Gaps = 40/340 (11%)
Query: 164 NAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK 223
+A++T ++ EEL KE A+S ++ + N E +K + K+P+ +
Sbjct: 186 SAVSTRHKKADRYIEELTKER-------DALSLELYRNTITNEELKKKNAELQEKLPLAE 238
Query: 224 VTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKT 283
S + V + ++ L++ F+ P L+ +
Sbjct: 239 SEKSEIQLNVKELKRKLERA-------------KFLL--------PQVQTNTLQEEMWRQ 277
Query: 284 QDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDN 343
++E+++ EK +K R++E ++ + K +++ E++++ +++ +QE
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRL--------REQEKE 329
Query: 344 QKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLES 403
+++E++ ++QK E ++++ E K Q ++ E+E+K ++ +R ++ + +
Sbjct: 330 LREQEKELREQKELRE--QEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 404 YTQQKKEQEEFL-RLEKEIREKAEKAEKRKNAADEISRF-QERDLHKLELKILDRQAKED 461
Q+ ++QEE + ++ +REK E+ +++ +++ + +E+ + + E K D++ K
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQ 447
Query: 462 EKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKK 501
E+ + + R K++E+ E ++ + WE+ K+
Sbjct: 448 EEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
Score = 65.5 bits (158), Expect = 1e-10
Identities = 81/400 (20%), Positives = 183/400 (45%), Gaps = 70/400 (17%)
Query: 118 KTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIY 177
K + A++Q++L + ++Q +K++K +E+ + ++ +++ NT +EE
Sbjct: 224 KKKNAELQEKLPLAESEKSEIQLNVKELKRK---LERAKFLLPQVQT--NTLQEEMWRQE 278
Query: 178 EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFE 237
EEL ++EK + EK +R E
Sbjct: 279 EELREQEKKIRKQ-----------------EEKMWRQ----------------------E 299
Query: 238 KFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEK---WY 294
+ L++ G+ ++ + ++R + K +E+ E + Q+E Q ++ W
Sbjct: 300 ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWE 359
Query: 295 QKFLALEERKK---ESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR 351
Q+ E+ +K + ++W+ +KQ + +E K++++ + +Q++ ++KEE+
Sbjct: 360 QEEKMREQEEKMWRQEERLWEQEKQMREQEQ-KMRDQEERMW-----EQDERLREKEERM 413
Query: 352 KKQKLAVEAWKKQKSIEMSMKCASQLKE-EEEKEKKHQKERQRQFKLKLLLESYT----- 405
++Q+ + W++ + + K Q K+ +++EK ++ER R+ + K+ E T
Sbjct: 414 REQE---KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE 470
Query: 406 --QQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEK 463
QK+E+ + + EKE +++ +K K E + QE + + E KI D++ ++
Sbjct: 471 EKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
Query: 464 SQKQRRLAKLKEKVENNVSRDPSRLYKPTKGW--EERTKK 501
+K R K++E+ + ++ + K W EER +K
Sbjct: 531 -KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEK 569
Score = 65.1 bits (157), Expect = 2e-10
Identities = 81/426 (19%), Positives = 186/426 (43%), Gaps = 53/426 (12%)
Query: 58 WKQKVNQTKKAEFVRTAEKFKNQVINMEKDK----HSHFYNQKSDFRIEHSMLEELENKL 113
W+Q+ Q ++ + EK ++Q ++K Q+ + + + E K+
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLK---DVKPTPDFVEKLREMMEEIENAINTFK 170
+ K Q+Q K + +K++ + + K + E +RE E+++ +
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
Query: 171 EEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLP 230
E++ ++E+ EEK E ++ W + EK + ++P K
Sbjct: 621 EQEEKMWEQ---EEKMQEQEEKMWEQEEKMW----EQEEKMWE--QQRLPEQK------- 664
Query: 231 EEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQH 290
E++ + EK +Q ++ ++ + K + + K E++ E ++ +++
Sbjct: 665 EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE------EESMRER 718
Query: 291 EKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQ 350
EK ++ + ++E +Q + K Q++ EE+++ +EK E +K E+Q
Sbjct: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM----------WEQEEKMWEQQ 768
Query: 351 R---KKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEK---KHQKERQRQFKLKLLLESY 404
R +K+KL W+ +K E + K +++EK + +K R ++ K++ E
Sbjct: 769 RLPEQKEKL----WEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKM 824
Query: 405 TQQKK----EQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKE 460
Q++ ++E+ E+++ + EK E++ +E R QE + E K+ +++ K
Sbjct: 825 WGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
Query: 461 DEKSQK 466
+ +K
Sbjct: 885 RGQEEK 890
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 78.6 bits (192), Expect = 1e-14
Identities = 84/431 (19%), Positives = 205/431 (47%), Gaps = 59/431 (13%)
Query: 56 QNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIH 115
+ ++++ Q ++ E R KF + + +++H F R E +L+E E + +H
Sbjct: 1430 RKFREEEQQVRRQERER---KFLEEEQQLRQERHRKF-------REEEQLLQEREEQQLH 1479
Query: 116 SRKTERAKIQ--QQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQ 173
++ +R ++ QQL + + K + +L+ +P F+E+ +++ + + +EEQ
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ-QRQRKFLQEEQ 1538
Query: 174 RLIYEELIKEEKTTNN----ELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTL 229
+L +E ++ + + E + ++ + L E ++ FR + KV
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR-----LEEQKVRRQEQ 1593
Query: 230 PEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQ 289
+ ++ E+ L++ G+Q + D + F E+ E L + +++
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRK--------------FRED--EQLLQEREEQQLH 1637
Query: 290 HEKWYQKFLALEE--RKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK----QEDN 343
++ +KFL E R++E Q + + +K E +L ++ + + + +E+
Sbjct: 1638 RQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 344 QKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLES 403
Q+ + ++R+++ L E +++ +E + QL++E E+E+ ++ER R K+L E
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR----KILEEE 1753
Query: 404 YTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEK 463
+ ++E+++ R E++ + + E+ + QER+ +L + DR+ +E+E+
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLR-----------QEREEQQLRSQESDRKFREEEQ 1802
Query: 464 SQKQRRLAKLK 474
+++R +L+
Sbjct: 1803 LRQEREEQQLR 1813
Score = 74.7 bits (182), Expect = 2e-13
Identities = 85/393 (21%), Positives = 179/393 (45%), Gaps = 24/393 (6%)
Query: 95 QKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEK 154
Q+ D R +LE + R+ +R + +++LA+ +K + + + D E+
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRD--EE 172
Query: 155 LREMMEEIENAINTFKEEQRLIY------EELIKEEKTTNNELSAISRKIDTWALGNSET 208
L +E + EE++L EE EE+ EL + RK G E
Sbjct: 173 LWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRK------GREEK 226
Query: 209 EKAFRAISSKVPVDKVTPSTLPEEVL---DFEKFLQQTGGRQGAWDDYDHQNFVKVRNKH 265
++ R +V ++ E + + EK ++ RQ + + Q R +
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 266 KGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKL 325
+ + E+ + L + Q +Q E+ ++ E+++ Q + ++QQ R E +
Sbjct: 287 RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEER 346
Query: 326 KEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEK 385
+E+ +++ ++++EE+R++Q+L E +Q E ++ QL+ E++ +
Sbjct: 347 REQQLRREQEEERREQQLRREQEEERREQQLRRE---QQLRREQQLRREQQLRREQQLRR 403
Query: 386 KHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAA--DEISRFQE 443
+ Q R++Q + + L Q ++EQEE +K +E+ E+ KR+ D + R +E
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 444 RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEK 476
+ H+ E + +Q K D++ +++ R KL+E+
Sbjct: 464 TERHEQERR--KQQLKRDQEEERRERWLKLEEE 494
Score = 73.6 bits (179), Expect = 4e-13
Identities = 96/444 (21%), Positives = 213/444 (47%), Gaps = 35/444 (7%)
Query: 75 EKFKNQVINMEKDKHSHFYNQKSDF--RIEHSMLEELENKLIHSRKTERAKIQQQLAK-- 130
EK + + E++K F ++ R L+E E+ L ++ R++ Q++ K
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 131 --IHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEE--LIKEEKT 186
+ K+ +H L + + K +++++E E + + E+R E+ +EE+
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935
Query: 187 TNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGR 246
E + R+ + E E+ +R + + L EE EK +Q +
Sbjct: 936 LQQEEEQLLRE-EREKRRRQERERQYRKDKK---LQQKEEQLLGEEP---EKRRRQEREK 988
Query: 247 QGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKE 306
+ ++ Q ++ + + K E ++ + +DE+QQ E+ L EER+K
Sbjct: 989 KYREEEELQQEEEQLLREEREKRRRQEWERQY---RKKDELQQEEEQ----LLREEREKR 1041
Query: 307 SIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQE-DNQKQKEE--QRKKQKLAVEAWKK 363
+Q + ++ ++ EE+ + +E+ +QE + Q +KEE Q+++++L E +K
Sbjct: 1042 RLQE-RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 364 QKSIEMSMKCASQ--LKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI 421
++ E +C + L++EEE+ + ++E++R+ +L+ + ++E+E+ LR E E
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 422 REKAEKAEKRKNAADEISRFQERDLHKLELKIL---DRQAKEDEKSQKQRRLAKLKEKVE 478
R + E E++ +E+ + +E+ L + + K +RQ +E+E+ Q+Q+R + +++ +
Sbjct: 1161 RRRQE-LERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ 1219
Query: 479 NNVSRDPSRLYKPTKGWEERTKKI 502
+ D ++P K R K+
Sbjct: 1220 RS---DLKWQWEPEKENAVRDNKV 1240
Score = 69.7 bits (169), Expect = 6e-12
Identities = 81/441 (18%), Positives = 202/441 (45%), Gaps = 37/441 (8%)
Query: 78 KNQVINMEKDKHSHFYNQKS-DFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVK 136
+ V+ E++K Q+ + + E L +LE + + + E + QQ+L + +
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 137 KLQHQLKDVKPTPDFVEKLREMMEEI-ENAINTFKEEQRLIYEELIKEEKTTNNELSAIS 195
K + + ++ + ++ RE EE E + +EE+R E+ ++ E+ +
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERR---EQQLRREQEEERREQQLR 365
Query: 196 RKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFL---QQTGGRQGAWDD 252
R+ E E+ + + + + + E+ L E+ L QQ Q +
Sbjct: 366 RE--------QEEERREQQLRREQQLRR-EQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 253 YDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALE--ERKKESIQI 310
+ ++R + + + + E + + E ++ W ++ E E+++ Q+
Sbjct: 417 QQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQL 476
Query: 311 WKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMS 370
+ +++++RE KL+E+ ++E ++++E+R++Q+L + ++++ ++
Sbjct: 477 KRDQEEERRERWLKLEEEERREQ---QERREQQLRREQEERREQRLKRQ--EEEERLQQR 531
Query: 371 MKCASQLKEEEE---------KEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI 421
++ QL+ E+E +E+K ++ +R+ +LK E Q ++EE R ++
Sbjct: 532 LRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLK 591
Query: 422 REKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNV 481
RE+ E+ E+R +E+ R ++ + + LK R+ E+E+ Q+ + + +E+ + +
Sbjct: 592 REQEERLEQRLK-REEVERLEQEERREQRLK---REEPEEERRQQLLKSEEQEERRQQQL 647
Query: 482 SRDPSRLYKPTKGWEERTKKI 502
R+ + EE +++
Sbjct: 648 RREQQERREQRLKREEEEERL 668
Score = 69.3 bits (168), Expect = 8e-12
Identities = 90/470 (19%), Positives = 207/470 (44%), Gaps = 63/470 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSML-EELENKLIHSR 117
K+ + ++ R E+ ++Q++ E+++ ++ + R+E + EE+E R
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 118 KTERAKIQ-------QQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFK 170
+ +R K + QQL K ++ Q QL+ RE E E + +
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLR------------REQQERREQRLKREE 663
Query: 171 EEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK--VTPST 228
EE+RL E+ +K E ++ + E E+A I S++P + +
Sbjct: 664 EEERL--EQRLKREHEEERREQELAEE---------EQEQARERIKSRIPKWQWQLESEA 712
Query: 229 LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDE-- 286
+ + + +Q G R+ Q + R + + + + EE H + +++
Sbjct: 713 DARQSKVYSRPRKQEGQRR-------RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 287 --------VQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHN 338
++ E+ Q+ A +++ + + +++Q+RE+ F L E+ +
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF-LPEEEEKEQRRRQR 824
Query: 339 KQEDNQKQ---KEEQRKKQKLAVEAWKKQKSI-EMSMKCASQLKEEEEKEKKHQKERQRQ 394
++ + + Q +EEQ ++++ A + +++ + E + SQ + ++K + +E +++
Sbjct: 825 REREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 395 FKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKIL 454
+ L + Q++ +E+ L E+E + E+ EKR+ E +E L + E ++L
Sbjct: 885 RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLL 944
Query: 455 DRQ---AKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKK 501
+ + E+ ++ R+ KL++K E + +P + + +ER KK
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR-----QEREKK 989
Score = 68.6 bits (166), Expect = 1e-11
Identities = 91/427 (21%), Positives = 196/427 (45%), Gaps = 38/427 (8%)
Query: 85 EKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKD 144
E+++ Q+ + E LEE E ++ ERA QQL + + +++ Q + +
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQL----QRRERA---QQLQEEEDGLQEDQERRRS 865
Query: 145 VKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALG 204
+ D +K R +EE + + E+L KE++ E + R+
Sbjct: 866 QEQRRD--QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE------- 916
Query: 205 NSETEKAFRAISSKVPVDKVTPSTLPEEVL--DFEKFLQQTGGRQGAWDDYDHQNFVKVR 262
E EK R + ++ E++L + EK +Q RQ D Q ++
Sbjct: 917 --EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Query: 263 NKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKT---KKQQKR 319
+ K E ++ + ++E+QQ E+ L EER+K Q W+ KK + +
Sbjct: 975 GEEPEKRRRQEREKKY---REEEELQQEEEQ----LLREEREKRRRQEWERQYRKKDELQ 1027
Query: 320 EEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEA-WKKQKSIEMSMKCASQLK 378
+E +L + L +++ ++++ +Q ++Q L E ++++ +E + +L+
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 379 EEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEI 438
+EEE+ + + E++R+ + + + ++E+E+ LR E+E R + E E++ +E+
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE-LERQYREEEEV 1146
Query: 439 SRFQERDL----HKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKG 494
+ +E+ L K + L+RQ +E+E+ Q++ +E+ + R+ R Y+ +
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE--RQYREEEE 1204
Query: 495 WEERTKK 501
+ + +K
Sbjct: 1205 LQRQKRK 1211
Score = 65.9 bits (159), Expect = 9e-11
Identities = 55/233 (23%), Positives = 119/233 (51%), Gaps = 44/233 (18%)
Query: 273 EEVLEHLPGKTQDEV--QQHEKWYQKFLALEERKKESIQIWKTK----------KQQKRE 320
+E LE + +DE +Q ++W ++ EER+ E Q+ K +Q +R
Sbjct: 158 QERLEQRDRQRRDEELWRQRQEWQER----EERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 321 EIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEE 380
E+ +L+ K +++ Q+++ + R Q+ + W+K++++ L++E
Sbjct: 214 ELLELRRKG--------REEKQQQRRERQDRVFQEEEEKEWRKRETV---------LRKE 256
Query: 381 EEKEKKHQKERQRQF-----KLKLL----LESYTQQKKEQEEFLRLEKEIREKAEKAEKR 431
EEK ++ + +RQR+ +L+ L L Q++++Q++ LR E+++R K E E+R
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE--EER 314
Query: 432 KNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRD 484
+ +E QER + E + + +++E+ ++Q R + +E+ E + R+
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367
Score = 63.9 bits (154), Expect = 3e-10
Identities = 84/469 (17%), Positives = 207/469 (44%), Gaps = 33/469 (7%)
Query: 56 QNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIH 115
Q +++ ++ + R + + Q + E+++ H + + R + E+ E +
Sbjct: 399 QQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWL 458
Query: 116 SRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRL 175
R+ E + +Q+ K +K+ Q + + + E+ RE E E + +EE+R
Sbjct: 459 KREEETERHEQERRK--QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR- 515
Query: 176 IYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
E+ +K ++ E + +++ + E E+ R K +K E+ L
Sbjct: 516 --EQRLKRQE----EEERLQQRLRSEQQLRREQEER-REQLLKREEEKRLEQERREQRLK 568
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEV-----QQH 290
E+ ++ + ++ Q +K + + + E +E L + + E +
Sbjct: 569 REQ--EERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPE 626
Query: 291 EKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKE-- 348
E+ Q+ L EE+++ Q + ++Q++RE+ K +E+ + + E+ ++++E
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELA 686
Query: 349 -----EQRKKQKLAVEAWKKQKSIE----MSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
+ R++ K + W+ Q E S + K+E ++ ++ Q+E++R+ + +L
Sbjct: 687 EEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL 746
Query: 400 LLESYT-----QQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKIL 454
+ QQ++EQ + + EK+E+ +R +A + +ER L E +
Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 455 DRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG 503
+++ +E+ ++QRR + + + E + +L + + + + ++ G
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Score = 58.2 bits (139), Expect = 2e-08
Identities = 95/454 (20%), Positives = 203/454 (44%), Gaps = 43/454 (9%)
Query: 64 QTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAK 123
Q +K E ++ E+ Q++ E +K ++ R E + +E E L R+ R +
Sbjct: 1079 QYRKEEELQQEEE---QLLREEPEKRRR-QERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 124 IQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLR-------EMMEEIENAINTFKEEQRLI 176
++ + V++ + QL +P ++L E+ +E E + +E++R
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 177 YEELIKEEKTTNNELSAI-----SRKIDTWALGNSETEKAFR--AISSKVPVDKVTPSTL 229
E +EE+ + ++ D E E A R + K ++
Sbjct: 1195 RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Query: 230 PEEVLD--FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEV 287
++ D ++ LQ G Q D + + R++H + +E E K +D
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE-EQKEAKRRDRK 1313
Query: 288 QQHEKWYQKFLALEERKK-ESIQIWKTKKQ--QKREEIFKLKEKADNT---PVLFHNKQ- 340
Q EK + E+R++ E+ + ++ ++Q Q+REE +++ D L H +Q
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373
Query: 341 ----EDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFK 396
E+ Q+ + ++R+++ L E + + E ++ K EE+++ ++ER R+F+
Sbjct: 1374 RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 397 LKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDR 456
+ E ++++ + +FL E+++R+ E+ K + + +E+ LH+ E DR
Sbjct: 1434 EE---EQQVRRQERERKFLEEEQQLRQ--ERHRKFREEEQLLQEREEQQLHRQE---RDR 1485
Query: 457 QAKEDEKS-QKQRRLAKLKEKVENNVSRDPSRLY 489
+ E+E+ ++Q R K +E + S++P R +
Sbjct: 1486 KFLEEEQQLRRQERDRKFRE--QELRSQEPERKF 1517
Score = 56.2 bits (134), Expect = 7e-08
Identities = 96/473 (20%), Positives = 203/473 (42%), Gaps = 102/473 (21%)
Query: 78 KNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKK 137
+ + + E+ + Q+ +R E + +E E L R+ R + +++ + +++
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 138 LQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEE--LIKEE--KTTNNELSA 193
+ QL +P EK R E ++EE+ L EE L++EE K E
Sbjct: 969 KEEQLLGEEP-----EKRRRQERE-----KKYREEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 194 ISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDY 253
RK D E E+ R K + + EE L E+ +Q G +
Sbjct: 1019 QYRKKDEL---QQEEEQLLREEREKRRLQERERQYREEEELQQEE--EQLLGEE------ 1067
Query: 254 DHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKT 313
+ T + LE K ++E+QQ E+ + + R++E + +
Sbjct: 1068 --------------RETRRRQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCRE 1112
Query: 314 KKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEE----QRKKQKLAVEAWKKQK-SIE 368
+++ ++EE L+E+ + +QE ++ +EE Q ++Q L E K+++ +E
Sbjct: 1113 EEELQQEEEQLLREEREK-----RRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 369 MSMKCASQLKEEE-----EKEKKHQKERQRQFKLKLLLESYTQQK--------------- 408
+ +L++EE E+++K ++ER+RQ++ + L+ +++
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 409 -----------------KEQEEFLRLE-KEIREKAEK--------AEKRKNAADEISRFQ 442
+E E+F +LE ++R++ + ++ ++ E R+Q
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ 1287
Query: 443 ERDLHKLELKILDRQ-----AKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYK 490
+RD H E + L+R+ + D KSQ++++L + +E+ E ++ R ++
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR-EEREEKRRRQETDRKFR 1339
Score = 53.9 bits (128), Expect = 4e-07
Identities = 49/243 (20%), Positives = 119/243 (48%), Gaps = 12/243 (4%)
Query: 264 KHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIF 323
+ KG+ ++ E Q+E ++ + + L EE K + + + ++ Q+ EE
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 324 KLKEKADNTPVLFHNKQEDNQKQ---KEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEE 380
+ E+ + L +QE+ Q+Q + EQ+ ++K E ++Q+ + Q +E
Sbjct: 279 RKLERQE----LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 381 EEKE-KKHQKERQRQFKLKLLLESYTQQ--KKEQEEFLRLEKEIREKAEKAEKRKNAADE 437
E++ ++ Q+ER+ Q + E +Q ++EQEE R ++ RE+ + E++ +
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 438 ISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEE 497
+ R E+ L + + ++Q + +++ +++++L + +E+ + + R + K +E
Sbjct: 395 LRR--EQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 498 RTK 500
+
Sbjct: 453 ERR 455
Score = 52.0 bits (123), Expect = 1e-06
Identities = 77/412 (18%), Positives = 185/412 (44%), Gaps = 29/412 (7%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLI 114
L+ +Q Q ++ +F++ ++ + Q ++ + ++ FR E + +E E + +
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ-----DRDRKFREEEQLRQEREEQQL 1572
Query: 115 HSRKTERA-KIQQQLAKIHNNVKKL---QHQLKDVKPTPDFVEKLREMMEEIENAINTFK 170
++ +R ++++Q + +K + QL+ + ++ E E + +
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQE-R 1631
Query: 171 EEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLP 230
EEQ+L +E ++ +L R+ + ++ FR + +
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQL----RHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 231 EEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQH 290
E F + QQ ++ + ++ + + F EE E L +T+ E +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER---KFREE--EQLRQETEQEQLRR 1742
Query: 291 EKWYQKFLALEERK--KESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKE 348
++ Y+K L E+ + +E Q+ + ++ +K E +L+++ + + QE ++K +E
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL---RSQESDRKFRE 1799
Query: 349 EQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQK 408
E++ +Q+ + + Q+ + + + + EE+E++ ++ER RQ++ + + TQ+K
Sbjct: 1800 EEQLRQEREEQQLRPQQR-DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE--QFATQEK 1856
Query: 409 KEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQ-ERDLHKLELKILDRQAK 459
+EE L +E +K + +RK + I R Q E H+ +I ++ K
Sbjct: 1857 SRREE-QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 47.8 bits (112), Expect = 3e-05
Identities = 70/393 (17%), Positives = 173/393 (44%), Gaps = 72/393 (18%)
Query: 51 RPFHLQNWKQKVNQTKKAEFVRTAEKFKNQV----INMEKDKHSHFYNQKSDFRIEHSML 106
R F L+ K + Q ++ +F+ ++ + Q + E+D+ FR + +L
Sbjct: 1579 RKFRLEEQKVR-RQEQERKFMEDEQQLRRQEGQQQLRQERDRK---------FREDEQLL 1628
Query: 107 EELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAI 166
+E E + +H ++ +R ++++ +L+ Q ++ + D K RE + ++
Sbjct: 1629 QEREEQQLHRQERDRKFLEEE--------PQLRRQEREQQLRHDRDRKFREEEQLLQEG- 1679
Query: 167 NTFKEEQRLIYEELIKEEKTTNNELSAISRKI----DTWALGNSETEKAFRAISSKVPVD 222
EEQ+L +E ++ + +L R+ + L E E+ FR
Sbjct: 1680 ----EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFR--------- 1726
Query: 223 KVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGK 282
+ E+ Q+T Q +R + + + EE L P +
Sbjct: 1727 ------------EEEQLRQETEQEQ-------------LRRQERYRKILEEEQLR--PER 1759
Query: 283 TQDEVQQHE---KWYQKFLALEERKKESIQIWKT-KKQQKREEIFKLKEKADNTPVLFHN 338
+ ++++ E K+ ++ +ER+++ ++ ++ +K ++ E++ + +E+ P
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 339 KQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLK 398
K ++Q + + ++Q+L E +Q E + + EE++ + +++++RQ + +
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQER-DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERER 1878
Query: 399 LLLESYTQQKKEQEEFLRLEKEIREKAEKAEKR 431
L E + ++++++E+ R EI+ + K R
Sbjct: 1879 KLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGR 1911
Score = 46.6 bits (109), Expect = 6e-05
Identities = 35/145 (24%), Positives = 81/145 (55%), Gaps = 8/145 (5%)
Query: 334 VLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQR 393
+L +QE++Q++ E + ++ + ++QK E + A ++ E++E+ Q++RQR
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQR 168
Query: 394 QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKI 453
+ + E + Q+++ QE R +E + ++ K + + DE + + R+L LEL+
Sbjct: 169 RDE-----ELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDE-EQLRRREL--LELRR 220
Query: 454 LDRQAKEDEKSQKQRRLAKLKEKVE 478
R+ K+ ++ ++Q R+ + +E+ E
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKE 245
Score = 30.4 bits (67), Expect = 4.2
Identities = 18/80 (22%), Positives = 43/80 (53%), Gaps = 5/80 (6%)
Query: 402 ESYTQQKKEQEEFLRLEKEIREKAE-----KAEKRKNAADEISRFQERDLHKLELKILDR 456
ES Q ++++E+ R E R+ E + +KR+ E++ +E+ + L+ DR
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDR 166
Query: 457 QAKEDEKSQKQRRLAKLKEK 476
Q +++E ++++ + +E+
Sbjct: 167 QRRDEELWRQRQEWQEREER 186
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 77.8 bits (190), Expect = 2e-14
Identities = 84/448 (18%), Positives = 208/448 (46%), Gaps = 29/448 (6%)
Query: 58 WKQKVNQTKKAEFV-RTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
W+Q+ ++ E + R E+ Q M +++ +Q+ + L E E ++
Sbjct: 320 WEQEEKMREQEEKMWRQEERLWEQEKQM-REQEQKMRDQEERMWEQDERLREKEERMREQ 378
Query: 117 RKT-ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMM---EEIENAINTFKEE 172
K E+ + Q+ +I KK++ + + ++ + ++K E M EE E E+
Sbjct: 379 EKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQ 438
Query: 173 QRLIYEE--LIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLP 230
+ ++E+ + ++E+ + I + + W + +K +R + D++
Sbjct: 439 KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG----QEKKMWRQEKMREQEDQMWEQE-- 492
Query: 231 EEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQH 290
E++ D E+ + R D+ + ++R + K M + E + + + + Q+
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDERLREKEERMREQKK-----MWQQEEKMREEKKTQEQEK 547
Query: 291 EKWYQKF-LALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEE 349
+ W Q+ + EER +E + + +++ RE+ K++E+ + E +K +E+
Sbjct: 548 KTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQ 607
Query: 350 QRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKK 409
+ K + + W++++ +M + ++EE+ +++ +K +++ K++ E + ++
Sbjct: 608 EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMR---EQEEKMRE 664
Query: 410 EQEEFLRLEKEIREKAEK---AEKRKNAADEISRFQERDLHKLELKILDRQAK---EDEK 463
++E+ E+++RE+ EK E++ +E R QE + E K+ ++ K ++E
Sbjct: 665 QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEM 724
Query: 464 SQKQRRLAKLKEKVENNVSRDPSRLYKP 491
+K+ R+ KEK++ + R +P
Sbjct: 725 REKEERIRDQKEKMQERLPEHEERCSEP 752
Score = 73.6 bits (179), Expect = 4e-13
Identities = 88/462 (19%), Positives = 209/462 (45%), Gaps = 24/462 (5%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+Q+ ++ E +R EK + +++ QK R + ++E E K+ +
Sbjct: 266 EQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK-LREQEEQMQEQEEKMWEQEE 324
Query: 119 TERA---KIQQQLAKIHNNVKKLQHQLKDVKPTPDFV----EKLREMMEEIENAINTFKE 171
R K+ +Q ++ K+++ Q + ++ + + E+LRE E + +++
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ 384
Query: 172 EQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSET-----EKAFRAISSKVPVDKVTP 226
E+++ EE I+E + E R+ + E EK ++ +K+
Sbjct: 385 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWE 444
Query: 227 STLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDE 286
+E EK +Q + + + + + + K + + M E E + + Q
Sbjct: 445 QEKMQE--QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 502
Query: 287 VQQHEKWYQKFLAL---EERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDN 343
Q E+ +++ L EER +E ++W+ +++ + E+ K +E+ T +E+
Sbjct: 503 WDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEK--KTQEQEKKTWDQEEKMREEE 560
Query: 344 QKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKL-KLLLE 402
+ ++ E++ +++ + +++K E K Q ++ E+E+K Q++ ++ ++ + + E
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620
Query: 403 SYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDE 462
+ K +++E + E+E EK ++ E++ +E R QE + + E K+ ++ K E
Sbjct: 621 QEEEDKMQEQEEMMWEQE--EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMRE 678
Query: 463 KSQK-QRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIG 503
+ +K Q + K++E+ E ++ + K W + K G
Sbjct: 679 QEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWG 720
Score = 69.7 bits (169), Expect = 6e-12
Identities = 56/222 (25%), Positives = 114/222 (51%), Gaps = 19/222 (8%)
Query: 283 TQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEI-FKLKEKADNTPVLFHNKQE 341
T +E+++ Q+ L L E +K IQ+ + ++K E F L + NT QE
Sbjct: 181 TNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNT------LQE 234
Query: 342 DNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLL 401
+ +Q+EE R+++K K +K E + +L+E+E K ++ +++ +RQ K L
Sbjct: 235 EMWRQEEELREQEK------KIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR---L 285
Query: 402 ESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAA---DEISRFQERDLHKLELKILDRQA 458
++ +EQE+ LR +K++RE+ E+ ++++ +E R QE + + E ++ +++
Sbjct: 286 REQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEK 345
Query: 459 KEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTK 500
+ E+ QK R + + + + R+ + K WE+ K
Sbjct: 346 QMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEK 387
Score = 66.2 bits (160), Expect = 7e-11
Identities = 96/439 (21%), Positives = 186/439 (42%), Gaps = 65/439 (14%)
Query: 59 KQKVN-----QTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKL 113
K+K+N +T +E + E K ++ Q RI ELE L
Sbjct: 49 KKKINNGTNPETTTSEGCHSPEDEKKASHQHQEALRREIEAQDHTIRILTCQKTELETAL 108
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQ 173
+S+ R L + + +L H F +L+ + +A++T+ ++
Sbjct: 109 YYSQDAARKFEDGNLGESKDLAGRLHHSWH-------FAGELQRAL----SAVSTWHKKA 157
Query: 174 RLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEV 233
EEL KE + EL + + N+E ++ R S+ ++ L +
Sbjct: 158 DRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRK- 216
Query: 234 LDFEKFL----QQTGGRQGAWDDYDH--QNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEV 287
L+ KFL Q ++ W + + K+R K + K EE L GK ++
Sbjct: 217 LERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR-KQEEKMWRQEERLREQEGKMRE-- 273
Query: 288 QQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQK 347
Q EK ++ L E++KE + K ++QK KL+E+ + QE +K
Sbjct: 274 -QEEKMRRQEKRLREQEKELREQEKELREQK-----KLREQEEQM-------QEQEEKMW 320
Query: 348 EEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQ 407
E++ K ++ + W++++ + E+EK+ +++ Q+ + + ++
Sbjct: 321 EQEEKMREQEEKMWRQEERLW-------------EQEKQMREQEQKMRDQEERMWEQDER 367
Query: 408 KKEQEEFLRLEKEIREKAEK---------AEKRKNAADEISRFQERDLHKLELKILDRQA 458
+E+EE +R ++++ E+ EK EK+ +E R QE + K E +
Sbjct: 368 LREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE----ENMW 423
Query: 459 KEDEKSQKQRRLAKLKEKV 477
+++EK +Q+RL + KEK+
Sbjct: 424 EQEEKEWQQQRLPEQKEKL 442
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 77.8 bits (190), Expect = 2e-14
Identities = 95/404 (23%), Positives = 177/404 (43%), Gaps = 58/404 (14%)
Query: 170 KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKV--TPS 227
K + EL +E+ + EL K + S+ + R V +++ TP+
Sbjct: 450 KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPT 509
Query: 228 TLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEV 287
+ P V+ + F+++ + + + Q +R K + + ++V E + ++
Sbjct: 510 SAPRSVM--KSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVK 567
Query: 288 QQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQK 347
+ E+ +K L ER ++ + K + +QK +I + EKA + E+ K+K
Sbjct: 568 LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA-----EEKAKKK 622
Query: 348 EEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEE------EKEKKHQKERQRQF-KLKLL 400
+K ++ VEA +KQ+ ++ Q +EE +K+K+ ++ER R+ + K L
Sbjct: 623 AAAKKMEE--VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRL 680
Query: 401 LESYTQQKKEQE--EFLRLEKEIREKAEKAEKRKNAADEISRFQER-----------DLH 447
E Q+++EQE E R E+E RE+ + ++R+ A E R QER
Sbjct: 681 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL 740
Query: 448 KLELKILDRQAKEDEKSQKQRRLA--KLKEKVEN----------------NVSRDPSRLY 489
+L+ + L R+ +E +K ++Q+RLA +L+E+ E +V Y
Sbjct: 741 RLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSY 800
Query: 490 KPTKGWEERTKKIGPTGSGPLLHI---------PHRAIPTWRQG 524
+ T KI P G L+ P + IPTW +G
Sbjct: 801 QMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARG 844
Score = 29.6 bits (65), Expect = 7.1
Identities = 35/167 (20%), Positives = 68/167 (40%), Gaps = 18/167 (10%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+++V Q K+ + + +KF EK K +K+ + +EE+E + +
Sbjct: 581 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 640
Query: 119 TERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMME--------EIENAINTFK 170
R + QQ + + + LQ + ++ + E+LR+ E E E +
Sbjct: 641 ARRLRWLQQEEEERRHQELLQKKKEEEQ------ERLRKAAEAKRLAEQREQERREQERR 694
Query: 171 EEQRLIYEELIKEEKTTNNELSAISRKIDTWALGN----SETEKAFR 213
E++R E +E + +L+ R+ + L E EKA R
Sbjct: 695 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALR 741
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 77.4 bits (189), Expect = 3e-14
Identities = 97/439 (22%), Positives = 194/439 (44%), Gaps = 76/439 (17%)
Query: 48 GGIRPFHLQNWKQKV----NQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEH 103
G + ++N K++ ++ E + +K K +++ E+D +++ +K+
Sbjct: 138 GAVESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERK 197
Query: 104 SMLEELENKLIHSRKTE---RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMME 160
+E E + R + RA++Q QL K+++N +++ K++ +EK ++ M+
Sbjct: 198 EAKQEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEIEKDKKRMD 257
Query: 161 EIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVP 220
++E+ + K+E + E + EK + S +++K + KA S K+
Sbjct: 258 KVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQK-------RPQYIKAKENTSHKIK 310
Query: 221 VDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLP 280
+ +L QN K K KG M+E+
Sbjct: 311 KLEAAKKSL--------------------------QNAQKHYKKRKGD---MDEL----- 336
Query: 281 GKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKAD-NTPVLFHNK 339
+ E+ EK Q+F E + +S T ++ + ++ +LKE+A L
Sbjct: 337 ---EKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRAATLAQEL 393
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
++ N+ QK +Q +L +E ++K +E K +L+E EE +K+ +K
Sbjct: 394 EKFNRDQKADQ---DRLDLE---ERKKVETEAKIKQKLREIEENQKRIEK---------- 437
Query: 400 LLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAK 459
L E T K+ EE +LE E+ E+ E A++R DEI++ + + +L +DRQ
Sbjct: 438 LEEYITTSKQSLEEQKKLEGELTEEVEMAKRR---IDEINKELNQVMEQLGDARIDRQ-- 492
Query: 460 EDEKSQKQRRLAKLKEKVE 478
+S +Q+R A++ E ++
Sbjct: 493 ---ESSRQQRKAEIMESIK 508
Score = 53.5 bits (127), Expect = 5e-07
Identities = 51/209 (24%), Positives = 95/209 (45%), Gaps = 14/209 (6%)
Query: 282 KTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQ--QKREEIFKLKEKADNTPVLFHNK 339
+ +DEV + + Q F ++I K K+ K +EI K K++ D K
Sbjct: 211 RLKDEVVRAQVQLQLFKLYHNE----VEIEKLNKELASKNKEIEKDKKRMDKVEDELKEK 266
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
+++ K EQ++ +E K+K E++ K +K +E K +K + L+
Sbjct: 267 KKELGKMMREQQQ-----IEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQN 321
Query: 400 LLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAK 459
+ Y ++K + +E LEKE+ + ++ + +E S+ Q RDL E ++
Sbjct: 322 AQKHYKKRKGDMDE---LEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRL 378
Query: 460 EDEKSQKQRRLAKLKEKVENNVSRDPSRL 488
++E S++ LA+ EK + D RL
Sbjct: 379 KEEASKRAATLAQELEKFNRDQKADQDRL 407
Score = 46.2 bits (108), Expect = 7e-05
Identities = 46/202 (22%), Positives = 94/202 (46%), Gaps = 25/202 (12%)
Query: 321 EIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEA-----WKKQKSIEMSMKCAS 375
E +K + T + + Q+ ++RKK+ + E + ++K+I K A
Sbjct: 141 ESIAMKNPKERTALFEEISRSGELAQEYDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAK 200
Query: 376 QLKEEEEKEKKHQKE---RQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRK 432
Q KEE ++ ++ + E Q Q +L L + + +K +E KEI EK +KR
Sbjct: 201 QEKEEADRYQRLKDEVVRAQVQLQLFKLYHNEVEIEKLNKELASKNKEI----EKDKKRM 256
Query: 433 NAADEISRFQERDLHKL--ELKILDRQAKE--DEKSQKQRRLAKLKEKVENNVSR----- 483
+ ++ + ++++L K+ E + ++++ KE E +QK+ + K KE + + +
Sbjct: 257 DKVEDELKEKKKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAK 316
Query: 484 ----DPSRLYKPTKGWEERTKK 501
+ + YK KG + +K
Sbjct: 317 KSLQNAQKHYKKRKGDMDELEK 338
Score = 45.1 bits (105), Expect = 2e-04
Identities = 108/514 (21%), Positives = 212/514 (41%), Gaps = 101/514 (19%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHS--HFYNQKSDFRIEHSMLEELENK 112
LQN QK + +K + ++ + +++++EK + ++S + LEE + K
Sbjct: 319 LQN-AQKHYKKRKGDM----DELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVK 373
Query: 113 LIHSRKTERAK----IQQQLAKIHNNVKKLQHQL-----KDVKPTPDFVEKLREM----- 158
H K E +K + Q+L K + + K Q +L K V+ +KLRE+
Sbjct: 374 KYHRLKEEASKRAATLAQELEKFNRDQKADQDRLDLEERKKVETEAKIKQKLREIEENQK 433
Query: 159 -MEEIENAINTFK---EEQRLIYEELIKEEKTT-------NNELSAISRKIDTWALGNSE 207
+E++E I T K EEQ+ + EL +E + N EL+ + ++ + E
Sbjct: 434 RIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQE 493
Query: 208 TEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQT---------GGRQGAW---DDYDH 255
+ + R + ++ P ++ ++D + Q+ G A +
Sbjct: 494 SSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKTG 553
Query: 256 QNFVKVRNKHKGKP-TFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTK 314
++ ++ + +G+P TF+ L++L K DE + K + L ++ + E I K
Sbjct: 554 RDCIQYIKEQRGEPETFLP--LDYLEVKPTDEKLRELKGAK--LVIDVIRYEPPHI-KKA 608
Query: 315 KQQKREEIFKLKEKADNTPVLFHNKQEDN---------QKQ----------KEEQRKKQK 355
Q D + F Q QK K + R+ +
Sbjct: 609 LQYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDE 668
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFK---LKLLLESYTQQKKEQE 412
AV+ K++K + +LKE+ + ++K + RQ Q + L++ L+ Y+Q EQ
Sbjct: 669 KAVDKLKEKKE-----RLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLK-YSQSDLEQT 722
Query: 413 EFLRLEKEIREKAEKAEK------RKNAADEISRFQERDLHKL----------------- 449
+ L ++EK++ + R N I + +ER++ L
Sbjct: 723 KTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLKEKMNQVEDEVFEEFCR 782
Query: 450 ELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSR 483
E+ + + + E+EK ++Q +AK + + EN +R
Sbjct: 783 EIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTR 816
Score = 43.5 bits (101), Expect = 5e-04
Identities = 87/456 (19%), Positives = 168/456 (36%), Gaps = 58/456 (12%)
Query: 39 QSDGCFSTSGGIRPFHLQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKH-----SHFY 93
Q G S + W +K K + R E+ K Q+ K+ S +
Sbjct: 647 QKSGVISGGASDLKAKARRWDEKAVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAH 706
Query: 94 NQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIH---NNVKKL----QHQLKDVK 146
+ + S LE+ + + + E++K++ +LA N++K++ + ++KD+K
Sbjct: 707 GLQMRLKYSQSDLEQTKTRHLALNLQEKSKLESELANFGPRINDIKRIIQSREREMKDLK 766
Query: 147 PTPDFVEK--LREMMEEIE-NAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWAL 203
+ VE E EI I F+EE+ E+ K+ N+ + + ++D
Sbjct: 767 EKMNQVEDEVFEEFCREIGVRNIREFEEEKVKRQNEIAKKRLEFENQKTRLGIQLDFEKN 826
Query: 204 GNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRN 263
E + V D+ L +E K + +T D +Q+ K ++
Sbjct: 827 QLKEDQDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDET---MAQLQDLKNQHLAK-KS 882
Query: 264 KHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIF 323
+ K MEE+ + L G ++ ++ LE+++ + + + K Q
Sbjct: 883 EVNDKNHEMEEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQD----I 938
Query: 324 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSM-KCASQLKEEEE 382
KL + QE+ Q E+ + + ++ IE+ LK+ +
Sbjct: 939 KLPLSKGTMDDI---SQEEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQA 995
Query: 383 KEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQ 442
+E+ Q E T Q+K E+ L++ + EK ++ D +FQ
Sbjct: 996 EEEIKQ-------------EMNTLQQKLNEQQSVLQRIAAPNMKAMEKLESVRD---KFQ 1039
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVE 478
E DE ++R K K+ E
Sbjct: 1040 ETS---------------DEFEAARKRAKKAKQAFE 1060
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 74.7 bits (182), Expect = 2e-13
Identities = 95/408 (23%), Positives = 179/408 (43%), Gaps = 62/408 (15%)
Query: 170 KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKV--TPS 227
K + EL +E+ + EL K + S+ + R V +++ TP+
Sbjct: 450 KRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPT 509
Query: 228 TLPEEVLDFEKFLQQTG----GRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKT 283
+ P V+ + F+++ + ++ + + Q +R K + + ++V E +
Sbjct: 510 SAPRSVM--KSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRL 567
Query: 284 QDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDN 343
++ + E+ +K L ER ++ + K + +QK +I + EKA + E+
Sbjct: 568 EEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLA-----EEK 622
Query: 344 QKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEE------EKEKKHQKERQRQF-K 396
K+K +K ++ VEA +KQ+ ++ Q +EE +K+K+ ++ER R+ +
Sbjct: 623 AKKKAAAKKMEE--VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 680
Query: 397 LKLLLESYTQQKKEQE--EFLRLEKEIREKAEKAEKRKNAADEISRFQER---------- 444
K L E Q+++EQE E R E+E RE+ + ++R+ A E R QER
Sbjct: 681 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 740
Query: 445 -DLHKLELKILDRQAKEDEKSQKQRRLA--KLKEKVEN----------------NVSRDP 485
+L+ + L R+ +E +K ++Q+RLA +L+E+ E +V
Sbjct: 741 EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 800
Query: 486 SRLYKPTKGWEERTKKIGPTGSGPLLHI---------PHRAIPTWRQG 524
Y+ T KI P G L+ P + IPTW +G
Sbjct: 801 CTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARG 848
Score = 29.6 bits (65), Expect = 7.1
Identities = 35/167 (20%), Positives = 68/167 (40%), Gaps = 18/167 (10%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+++V Q K+ + + +KF EK K +K+ + +EE+E + +
Sbjct: 585 RERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEE 644
Query: 119 TERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMME--------EIENAINTFK 170
R + QQ + + + LQ + ++ + E+LR+ E E E +
Sbjct: 645 ARRLRWLQQEEEERRHQELLQKKKEEEQ------ERLRKAAEAKRLAEQREQERREQERR 698
Query: 171 EEQRLIYEELIKEEKTTNNELSAISRKIDTWALGN----SETEKAFR 213
E++R E +E + +L+ R+ + L E EKA R
Sbjct: 699 EQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALR 745
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 72.4 bits (176), Expect = 1e-12
Identities = 55/207 (26%), Positives = 110/207 (53%), Gaps = 8/207 (3%)
Query: 302 ERKKESIQIWKTKKQQKREEIFKL--KEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE 359
ERKKE + K K+++++E + KEK ++E +K++E+QRK+++ E
Sbjct: 35 ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR---E 91
Query: 360 AWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEK 419
++++ E + Q E K+KK +KER+R+ K + + ++KK++ + + EK
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 420 EIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
E ++ K +KRK E R + R K E + +R+ ++ E+ +K+RR K ++K
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKER-KKERRKKKERKKDRK 210
Query: 480 NVSRDPSRLYKPTKGWEERTKKIGPTG 506
+ S++++P + E ++ TG
Sbjct: 211 TDRQTDSQVFRPLR--ESAFNRVTVTG 235
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/185 (23%), Positives = 91/185 (49%), Gaps = 23/185 (12%)
Query: 260 KVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKR 319
K R + +GK + + + + ++ EK ++ E RK++ + + +KQ+ R
Sbjct: 52 KERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR 111
Query: 320 EEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKE 379
E K KE+ + ++ +N++++E +RKK++ KK++ K + +
Sbjct: 112 RERKKKKERKE--------RERENKQRRERKRKKRRK-----KKRRKERKREKERGKRER 158
Query: 380 EEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEIS 439
+ +K KK ++E++R+ K ++KKE+E R E+ R+K K E+RK +
Sbjct: 159 KRKKRKKEEREKKRERNRK-------ERKKERE---RKERRERKKERKKERRKKKERKKD 208
Query: 440 RFQER 444
R +R
Sbjct: 209 RKTDR 213
Score = 49.3 bits (116), Expect = 9e-06
Identities = 29/130 (22%), Positives = 71/130 (54%)
Query: 372 KCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKR 431
K +Q + E +KE++ +++R+R+ + + E ++KK++++ R ++ R++ E+ ++R
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86
Query: 432 KNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKP 491
K ++ R ++++ K E K R+ ++ +K +K+R + + R + K
Sbjct: 87 KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 492 TKGWEERTKK 501
K +ER K+
Sbjct: 147 RKREKERGKR 156
Score = 45.1 bits (105), Expect = 2e-04
Identities = 37/159 (23%), Positives = 79/159 (49%), Gaps = 8/159 (5%)
Query: 260 KVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKR 319
K R K + + E K ++ Q+ + +K +ER++E+ K ++++KR
Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKEREREN----KQRRERKR 135
Query: 320 EEIFKLKEKADNTPVLFHNKQE-DNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLK 378
++ K K + + K+E +K+K+E+R+K++ E +K++ E K + K
Sbjct: 136 KKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKR---ERNRKERKKERERKERRERK 192
Query: 379 EEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRL 417
+E +KE++ +KER++ K +S + + F R+
Sbjct: 193 KERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRV 231
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 70.9 bits (172), Expect = 3e-12
Identities = 55/201 (27%), Positives = 103/201 (51%), Gaps = 2/201 (0%)
Query: 302 ERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE-A 360
+ K++ +Q K ++Q+ E+ +L++K + QE Q + E + +++ V A
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE 420
KKQ+ E+ + ++L+EEE++ ++ Q ER++ + L LE ++++ + L+LEK
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 421 IRE-KAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
E K +K E D+ + ++ LE +I D E+ +K + L KLK K E+
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 480 NVSRDPSRLYKPTKGWEERTK 500
+S RL K K +E K
Sbjct: 1035 MISELEVRLKKEEKSRQELEK 1055
Score = 63.5 bits (153), Expect = 4e-10
Identities = 95/477 (19%), Positives = 210/477 (44%), Gaps = 65/477 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+QK+N + K +R E+ +N + + ++ N + + L + + KL
Sbjct: 1329 RQKLNVSTK---LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 119 TERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE-MMEEIENAINTFKEEQRLI- 176
T A +++ + ++ L Q ++ D +EK + + +E+++ + +++L+
Sbjct: 1386 TVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 177 --------YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPST 228
+++L+ EEK +++ + + + A EK +A+S +++ +
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-----REKETKALSLARALEEALEAK 1499
Query: 229 LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
EE+ K L+ + D +N ++ + T MEE+ L + +DE+Q
Sbjct: 1500 --EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQ 1556
Query: 289 QHE----KWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQ 344
E + AL+ + + +Q + ++KR ++ + + +
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL--------------QRQLHEYE 1602
Query: 345 KQKEEQRKKQKLAVEAWKKQ----KSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLL 400
+ E++RK++ LA A KK K +E+ A + +EE K+ + + + + F+ +L
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL- 1661
Query: 401 LESYTQQKKEQEEFLRLEKEIREKAEKAE------KRKNAADEISRFQERDLHKLEL--- 451
+ ++E KE +KA+ E + AA E +R ++ DL K EL
Sbjct: 1662 ----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEE 1716
Query: 452 ---KILDRQAKEDEKSQKQRRLAKLKEKVE---NNVSRDPSRLYKPTKGWEERTKKI 502
+ R A +DEK + + R+A+L+E++E N+ R+ K T+ E+ + ++
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/398 (20%), Positives = 167/398 (41%), Gaps = 57/398 (14%)
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEK-------LREMMEEIENAI 166
+ +++ E K +++ K N +K+L+ + + + +++ L EE+ +
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 167 NTFKEEQRLIYEEL---IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK 223
K+E I E+ ++EE+ +L A +K+ L E + A K+ ++K
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 224 VTPST----LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHL 279
VT L +E+L D QN NK + +EE + L
Sbjct: 974 VTAEAKIKKLEDEILVM-----------------DDQN-----NKLSKERKLLEERISDL 1011
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
+E ++ K K E +++ K+++ R+E+ KLK K + FH +
Sbjct: 1012 TTNLAEE-EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 340 QEDNQ------------KQKEEQRKKQKLAVEAWKKQKSIEMSMKC---ASQLKEEEEKE 384
D Q K++E Q +L E +K +++ + S L+E+ + E
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 385 KKHQKERQRQFK-LKLLLESYTQQKKEQEEFLRLEKEIREKAE-KAEKRKNAADEISRFQ 442
+ + + ++Q + L LE+ + ++ + ++E+R K E + K A DE +R
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN 480
E + ++ K QA E E +++ + + K ++ N
Sbjct: 1191 EAQVQEMRQK--HAQAVE-ELTEQLEQFKRAKANLDKN 1225
Score = 50.8 bits (120), Expect = 3e-06
Identities = 93/466 (19%), Positives = 193/466 (41%), Gaps = 66/466 (14%)
Query: 60 QKVNQTKKAEF---VRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
++ N+ KAE V + + V +EK K + Q + + + LEELE++L
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEEMKTQ---LEELEDEL--- 1555
Query: 117 RKTERAKIQQQLAKIHNNVKKLQHQL-KDVKPTPDFVEKLREMMEEIENAINTFKEEQRL 175
+ TE AK++ ++ N++ L+ Q +D++ + E+ R ++ + T E++R
Sbjct: 1556 QATEDAKLRLEV-----NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 176 IYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+K +L + + D+ G E K R + +++ D
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--------------D 1656
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKG---------------------KPTFMEE 274
F++ L+ + +N K ++ K EE
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 275 VLEHLPGKT--QDEVQQHEK---WYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKA 329
+ L G+ QDE ++ E ++ L E+ E++ K Q+ E++
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 330 DNTPVLFHNKQEDNQKQKEEQRKK---QKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKK 386
+T + ++ ++Q +E R K + AV++ K + K A QL+E+ E+E +
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAR 1835
Query: 387 HQKE-----RQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRF 441
++ +Q+ KLK +L ++K E++ ++ + ++ +++ A+E S+
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 442 QERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSR 487
+ KL+ + LD + +E ++ K K + N S PSR
Sbjct: 1896 INANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNETSFVPSR 1940
Score = 44.7 bits (104), Expect = 2e-04
Identities = 73/427 (17%), Positives = 177/427 (41%), Gaps = 50/427 (11%)
Query: 63 NQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERA 122
N+ K+ E + + ++ + + Y + + R+ + ++ +++H +
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932
Query: 123 KIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE--MMEEIENAINTFKEEQRLIY--- 177
+ + + ++ KK+ Q+ D++ + E R+ +E++ K E ++
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 178 --EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+L KE K +S ++ + E EKA K + + + +
Sbjct: 993 QNNKLSKERKLLEERISDLTTNL------AEEEEKAKNLTKLKNKHESM--------ISE 1038
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
E L++ ++ Q K++ K +G + E + L + + Q K +
Sbjct: 1039 LEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 296 KFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQK 355
+ A R + I QK + K++E + L QED ++ + K +K
Sbjct: 1091 ELQAALARLDDEI-------AQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1139
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL 415
+ ++ ++++ ++ L +++ K Q LK L+ T+ + Q + +
Sbjct: 1140 QKRDLGEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 416 RLE-----KEIREKAEKAEKRKNAADEISRFQERDLHKL--ELKILDRQAKEDEKSQKQR 468
R + +E+ E+ E+ ++ K D+ + E++ L EL++L QAK++ + +K++
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKK 1256
Query: 469 RLAKLKE 475
A+++E
Sbjct: 1257 LEAQVQE 1263
Score = 40.4 bits (93), Expect = 0.004
Identities = 105/518 (20%), Positives = 200/518 (38%), Gaps = 99/518 (19%)
Query: 61 KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
+V K+ + + EK K + +E D S F+ Q +D + + + L+ K +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRK---LEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 121 RAKIQQQLAKIHNNVKK----------LQHQL--------KDVKPTPDFVEKLREMMEEI 162
A++ ++A+ +N +KK LQ L K K D E+L + E+
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 163 ENAINTF--------KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRA 214
E+ +++ K EQ + + +E+T ++E + TE+ +
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 215 ISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQ----------------NF 258
+K +DK TL +E D L+ G A + +H+ +
Sbjct: 1216 KRAKANLDK-NKQTLEKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 259 VKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQK 318
+ R + K ++ +E + G + + K + +L + +++ ++ + + +QK
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 319 REEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR-----------KKQKL--------AVE 359
KL++ + L E+ + ++ +R K+KL A+E
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 360 AWKK--QKSIE-----MSMKCASQLKEEEEKEKKHQ-------------------KERQR 393
KK QK IE K A+ K E+ K + Q +++QR
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 394 QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQ---ERDLHKLE 450
+F +LL E K +E R E E REK KA A +E + ER L+
Sbjct: 1452 KFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 451 LKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRL 488
++ D + +D+ + L K K +E + ++L
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 17/154 (11%)
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFK----LKLLLESYTQQKKEQ---EE 413
W+ ++ ++ Q +E + KE + QK ++RQ K LK L + ++Q +E+ +E
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 414 FLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAK- 472
L+ E E+ +AE+ R A + E LH++E ++ + + + + +++++A+
Sbjct: 895 QLQAETELYAEAEEMRVRLAAK---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 473 ---LKEKV-ENNVSRDPSRLYKPTKGWEERTKKI 502
L+E++ E +R +L K T E + KK+
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKL 983
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 70.9 bits (172), Expect = 3e-12
Identities = 55/201 (27%), Positives = 103/201 (51%), Gaps = 2/201 (0%)
Query: 302 ERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE-A 360
+ K++ +Q K ++Q+ E+ +L++K + QE Q + E + +++ V A
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE 420
KKQ+ E+ + ++L+EEE++ ++ Q ER++ + L LE ++++ + L+LEK
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 421 IRE-KAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
E K +K E D+ + ++ LE +I D E+ +K + L KLK K E+
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 480 NVSRDPSRLYKPTKGWEERTK 500
+S RL K K +E K
Sbjct: 1042 MISELEVRLKKEEKSRQELEK 1062
Score = 63.5 bits (153), Expect = 4e-10
Identities = 95/477 (19%), Positives = 210/477 (44%), Gaps = 65/477 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+QK+N + K +R E+ +N + + ++ N + + L + + KL
Sbjct: 1336 RQKLNVSTK---LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 119 TERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE-MMEEIENAINTFKEEQRLI- 176
T A +++ + ++ L Q ++ D +EK + + +E+++ + +++L+
Sbjct: 1393 TVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 177 --------YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPST 228
+++L+ EEK +++ + + + A EK +A+S +++ +
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-----REKETKALSLARALEEALEAK 1506
Query: 229 LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
EE+ K L+ + D +N ++ + T MEE+ L + +DE+Q
Sbjct: 1507 --EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQ 1563
Query: 289 QHE----KWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQ 344
E + AL+ + + +Q + ++KR ++ + + +
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL--------------QRQLHEYE 1609
Query: 345 KQKEEQRKKQKLAVEAWKKQ----KSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLL 400
+ E++RK++ LA A KK K +E+ A + +EE K+ + + + + F+ +L
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL- 1668
Query: 401 LESYTQQKKEQEEFLRLEKEIREKAEKAE------KRKNAADEISRFQERDLHKLEL--- 451
+ ++E KE +KA+ E + AA E +R ++ DL K EL
Sbjct: 1669 ----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEE 1723
Query: 452 ---KILDRQAKEDEKSQKQRRLAKLKEKVE---NNVSRDPSRLYKPTKGWEERTKKI 502
+ R A +DEK + + R+A+L+E++E N+ R+ K T+ E+ + ++
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/398 (20%), Positives = 167/398 (41%), Gaps = 57/398 (14%)
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEK-------LREMMEEIENAI 166
+ +++ E K +++ K N +K+L+ + + + +++ L EE+ +
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 167 NTFKEEQRLIYEEL---IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK 223
K+E I E+ ++EE+ +L A +K+ L E + A K+ ++K
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 224 VTPST----LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHL 279
VT L +E+L D QN NK + +EE + L
Sbjct: 981 VTAEAKIKKLEDEILVM-----------------DDQN-----NKLSKERKLLEERISDL 1018
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
+E ++ K K E +++ K+++ R+E+ KLK K + FH +
Sbjct: 1019 TTNLAEE-EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 340 QEDNQ------------KQKEEQRKKQKLAVEAWKKQKSIEMSMKC---ASQLKEEEEKE 384
D Q K++E Q +L E +K +++ + S L+E+ + E
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 385 KKHQKERQRQFK-LKLLLESYTQQKKEQEEFLRLEKEIREKAE-KAEKRKNAADEISRFQ 442
+ + + ++Q + L LE+ + ++ + ++E+R K E + K A DE +R
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN 480
E + ++ K QA E E +++ + + K ++ N
Sbjct: 1198 EAQVQEMRQK--HAQAVE-ELTEQLEQFKRAKANLDKN 1232
Score = 50.8 bits (120), Expect = 3e-06
Identities = 93/466 (19%), Positives = 193/466 (41%), Gaps = 66/466 (14%)
Query: 60 QKVNQTKKAEF---VRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
++ N+ KAE V + + V +EK K + Q + + + LEELE++L
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEEMKTQ---LEELEDEL--- 1562
Query: 117 RKTERAKIQQQLAKIHNNVKKLQHQL-KDVKPTPDFVEKLREMMEEIENAINTFKEEQRL 175
+ TE AK++ ++ N++ L+ Q +D++ + E+ R ++ + T E++R
Sbjct: 1563 QATEDAKLRLEV-----NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 176 IYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+K +L + + D+ G E K R + +++ D
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--------------D 1663
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKG---------------------KPTFMEE 274
F++ L+ + +N K ++ K EE
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 275 VLEHLPGKT--QDEVQQHEK---WYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKA 329
+ L G+ QDE ++ E ++ L E+ E++ K Q+ E++
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 330 DNTPVLFHNKQEDNQKQKEEQRKK---QKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKK 386
+T + ++ ++Q +E R K + AV++ K + K A QL+E+ E+E +
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAR 1842
Query: 387 HQKE-----RQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRF 441
++ +Q+ KLK +L ++K E++ ++ + ++ +++ A+E S+
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 442 QERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSR 487
+ KL+ + LD + +E ++ K K + N S PSR
Sbjct: 1903 INANRRKLQ-RELDEATESNEAMGREVNALKSKLRRGNETSFVPSR 1947
Score = 44.7 bits (104), Expect = 2e-04
Identities = 73/427 (17%), Positives = 177/427 (41%), Gaps = 50/427 (11%)
Query: 63 NQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERA 122
N+ K+ E + + ++ + + Y + + R+ + ++ +++H +
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 123 KIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE--MMEEIENAINTFKEEQRLIY--- 177
+ + + ++ KK+ Q+ D++ + E R+ +E++ K E ++
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 178 --EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+L KE K +S ++ + E EKA K + + + +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNL------AEEEEKAKNLTKLKNKHESM--------ISE 1045
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
E L++ ++ Q K++ K +G + E + L + + Q K +
Sbjct: 1046 LEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 296 KFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQK 355
+ A R + I QK + K++E + L QED ++ + K +K
Sbjct: 1098 ELQAALARLDDEI-------AQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1146
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL 415
+ ++ ++++ ++ L +++ K Q LK L+ T+ + Q + +
Sbjct: 1147 QKRDLGEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 416 RLE-----KEIREKAEKAEKRKNAADEISRFQERDLHKL--ELKILDRQAKEDEKSQKQR 468
R + +E+ E+ E+ ++ K D+ + E++ L EL++L QAK++ + +K++
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKK 1263
Query: 469 RLAKLKE 475
A+++E
Sbjct: 1264 LEAQVQE 1270
Score = 40.4 bits (93), Expect = 0.004
Identities = 105/518 (20%), Positives = 200/518 (38%), Gaps = 99/518 (19%)
Query: 61 KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
+V K+ + + EK K + +E D S F+ Q +D + + + L+ K +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRK---LEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 121 RAKIQQQLAKIHNNVKK----------LQHQL--------KDVKPTPDFVEKLREMMEEI 162
A++ ++A+ +N +KK LQ L K K D E+L + E+
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 163 ENAINTF--------KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRA 214
E+ +++ K EQ + + +E+T ++E + TE+ +
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 215 ISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQ----------------NF 258
+K +DK TL +E D L+ G A + +H+ +
Sbjct: 1223 KRAKANLDK-NKQTLEKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 259 VKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQK 318
+ R + K ++ +E + G + + K + +L + +++ ++ + + +QK
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 319 REEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR-----------KKQKL--------AVE 359
KL++ + L E+ + ++ +R K+KL A+E
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 360 AWKK--QKSIE-----MSMKCASQLKEEEEKEKKHQ-------------------KERQR 393
KK QK IE K A+ K E+ K + Q +++QR
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 394 QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQ---ERDLHKLE 450
+F +LL E K +E R E E REK KA A +E + ER L+
Sbjct: 1459 KFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 451 LKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRL 488
++ D + +D+ + L K K +E + ++L
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 17/154 (11%)
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFK----LKLLLESYTQQKKEQ---EE 413
W+ ++ ++ Q +E + KE + QK ++RQ K LK L + ++Q +E+ +E
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 414 FLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAK- 472
L+ E E+ +AE+ R A + E LH++E ++ + + + + +++++A+
Sbjct: 902 QLQAETELYAEAEEMRVRLAAK---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 473 ---LKEKV-ENNVSRDPSRLYKPTKGWEERTKKI 502
L+E++ E +R +L K T E + KK+
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKL 990
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 70.9 bits (172), Expect = 3e-12
Identities = 55/201 (27%), Positives = 103/201 (51%), Gaps = 2/201 (0%)
Query: 302 ERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE-A 360
+ K++ +Q K ++Q+ E+ +L++K + QE Q + E + +++ V A
Sbjct: 862 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 921
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE 420
KKQ+ E+ + ++L+EEE++ ++ Q ER++ + L LE ++++ + L+LEK
Sbjct: 922 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 981
Query: 421 IRE-KAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
E K +K E D+ + ++ LE +I D E+ +K + L KLK K E+
Sbjct: 982 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1041
Query: 480 NVSRDPSRLYKPTKGWEERTK 500
+S RL K K +E K
Sbjct: 1042 MISELEVRLKKEEKSRQELEK 1062
Score = 63.5 bits (153), Expect = 4e-10
Identities = 95/477 (19%), Positives = 210/477 (44%), Gaps = 65/477 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+QK+N + K +R E+ +N + + ++ N + + L + + KL
Sbjct: 1336 RQKLNVSTK---LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 119 TERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE-MMEEIENAINTFKEEQRLI- 176
T A +++ + ++ L Q ++ D +EK + + +E+++ + +++L+
Sbjct: 1393 TVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451
Query: 177 --------YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPST 228
+++L+ EEK +++ + + + A EK +A+S +++ +
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-----REKETKALSLARALEEALEAK 1506
Query: 229 LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
EE+ K L+ + D +N ++ + T MEE+ L + +DE+Q
Sbjct: 1507 --EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQ 1563
Query: 289 QHE----KWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQ 344
E + AL+ + + +Q + ++KR ++ + + +
Sbjct: 1564 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL--------------QRQLHEYE 1609
Query: 345 KQKEEQRKKQKLAVEAWKKQ----KSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLL 400
+ E++RK++ LA A KK K +E+ A + +EE K+ + + + + F+ +L
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL- 1668
Query: 401 LESYTQQKKEQEEFLRLEKEIREKAEKAE------KRKNAADEISRFQERDLHKLEL--- 451
+ ++E KE +KA+ E + AA E +R ++ DL K EL
Sbjct: 1669 ----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEE 1723
Query: 452 ---KILDRQAKEDEKSQKQRRLAKLKEKVE---NNVSRDPSRLYKPTKGWEERTKKI 502
+ R A +DEK + + R+A+L+E++E N+ R+ K T+ E+ + ++
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/398 (20%), Positives = 167/398 (41%), Gaps = 57/398 (14%)
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEK-------LREMMEEIENAI 166
+ +++ E K +++ K N +K+L+ + + + +++ L EE+ +
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 167 NTFKEEQRLIYEEL---IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK 223
K+E I E+ ++EE+ +L A +K+ L E + A K+ ++K
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 224 VTPST----LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHL 279
VT L +E+L D QN NK + +EE + L
Sbjct: 981 VTAEAKIKKLEDEILVM-----------------DDQN-----NKLSKERKLLEERISDL 1018
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
+E ++ K K E +++ K+++ R+E+ KLK K + FH +
Sbjct: 1019 TTNLAEE-EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 340 QEDNQ------------KQKEEQRKKQKLAVEAWKKQKSIEMSMKC---ASQLKEEEEKE 384
D Q K++E Q +L E +K +++ + S L+E+ + E
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 385 KKHQKERQRQFK-LKLLLESYTQQKKEQEEFLRLEKEIREKAE-KAEKRKNAADEISRFQ 442
+ + + ++Q + L LE+ + ++ + ++E+R K E + K A DE +R
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN 480
E + ++ K QA E E +++ + + K ++ N
Sbjct: 1198 EAQVQEMRQK--HAQAVE-ELTEQLEQFKRAKANLDKN 1232
Score = 45.4 bits (106), Expect = 1e-04
Identities = 88/453 (19%), Positives = 187/453 (41%), Gaps = 66/453 (14%)
Query: 60 QKVNQTKKAEF---VRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
++ N+ KAE V + + V +EK K + Q + + + LEELE++L
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEEMKTQ---LEELEDEL--- 1562
Query: 117 RKTERAKIQQQLAKIHNNVKKLQHQL-KDVKPTPDFVEKLREMMEEIENAINTFKEEQRL 175
+ TE AK++ ++ N++ L+ Q +D++ + E+ R ++ + T E++R
Sbjct: 1563 QATEDAKLRLEV-----NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 176 IYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+K +L + + D+ G E K R + +++ D
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--------------D 1663
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKG---------------------KPTFMEE 274
F++ L+ + +N K ++ K EE
Sbjct: 1664 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1723
Query: 275 VLEHLPGKT--QDEVQQHEK---WYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKA 329
+ L G+ QDE ++ E ++ L E+ E++ K Q+ E++
Sbjct: 1724 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1783
Query: 330 DNTPVLFHNKQEDNQKQKEEQRKK---QKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKK 386
+T + ++ ++Q +E R K + AV++ K + K A QL+E+ E+E +
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAR 1842
Query: 387 HQKE-----RQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRF 441
++ +Q+ KLK +L ++K E++ ++ + ++ +++ A+E S+
Sbjct: 1843 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1902
Query: 442 QERDLHKLELKILDRQAKEDEKSQKQRRLAKLK 474
+ KL+ + LD + +E ++ K K
Sbjct: 1903 INANRRKLQ-RELDEATESNEAMGREVNALKSK 1934
Score = 44.7 bits (104), Expect = 2e-04
Identities = 73/427 (17%), Positives = 177/427 (41%), Gaps = 50/427 (11%)
Query: 63 NQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERA 122
N+ K+ E + + ++ + + Y + + R+ + ++ +++H +
Sbjct: 880 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 123 KIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE--MMEEIENAINTFKEEQRLIY--- 177
+ + + ++ KK+ Q+ D++ + E R+ +E++ K E ++
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 999
Query: 178 --EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+L KE K +S ++ + E EKA K + + + +
Sbjct: 1000 QNNKLSKERKLLEERISDLTTNL------AEEEEKAKNLTKLKNKHESM--------ISE 1045
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
E L++ ++ Q K++ K +G + E + L + + Q K +
Sbjct: 1046 LEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 296 KFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQK 355
+ A R + I QK + K++E + L QED ++ + K +K
Sbjct: 1098 ELQAALARLDDEI-------AQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1146
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL 415
+ ++ ++++ ++ L +++ K Q LK L+ T+ + Q + +
Sbjct: 1147 QKRDLGEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 416 RLE-----KEIREKAEKAEKRKNAADEISRFQERDLHKL--ELKILDRQAKEDEKSQKQR 468
R + +E+ E+ E+ ++ K D+ + E++ L EL++L QAK++ + +K++
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKK 1263
Query: 469 RLAKLKE 475
A+++E
Sbjct: 1264 LEAQVQE 1270
Score = 40.4 bits (93), Expect = 0.004
Identities = 105/518 (20%), Positives = 200/518 (38%), Gaps = 99/518 (19%)
Query: 61 KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
+V K+ + + EK K + +E D S F+ Q +D + + + L+ K +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRK---LEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1102
Query: 121 RAKIQQQLAKIHNNVKK----------LQHQL--------KDVKPTPDFVEKLREMMEEI 162
A++ ++A+ +N +KK LQ L K K D E+L + E+
Sbjct: 1103 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1162
Query: 163 ENAINTF--------KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRA 214
E+ +++ K EQ + + +E+T ++E + TE+ +
Sbjct: 1163 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1222
Query: 215 ISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQ----------------NF 258
+K +DK TL +E D L+ G A + +H+ +
Sbjct: 1223 KRAKANLDK-NKQTLEKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSKCSDG 1278
Query: 259 VKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQK 318
+ R + K ++ +E + G + + K + +L + +++ ++ + + +QK
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 319 REEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR-----------KKQKL--------AVE 359
KL++ + L E+ + ++ +R K+KL A+E
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 360 AWKK--QKSIE-----MSMKCASQLKEEEEKEKKHQ-------------------KERQR 393
KK QK IE K A+ K E+ K + Q +++QR
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1458
Query: 394 QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQ---ERDLHKLE 450
+F +LL E K +E R E E REK KA A +E + ER L+
Sbjct: 1459 KFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1517
Query: 451 LKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRL 488
++ D + +D+ + L K K +E + ++L
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1555
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 17/154 (11%)
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFK----LKLLLESYTQQKKEQ---EE 413
W+ ++ ++ Q +E + KE + QK ++RQ K LK L + ++Q +E+ +E
Sbjct: 842 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 901
Query: 414 FLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAK- 472
L+ E E+ +AE+ R A + E LH++E ++ + + + + +++++A+
Sbjct: 902 QLQAETELYAEAEEMRVRLAAK---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 473 ---LKEKV-ENNVSRDPSRLYKPTKGWEERTKKI 502
L+E++ E +R +L K T E + KK+
Sbjct: 959 MLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKL 990
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 70.9 bits (172), Expect = 3e-12
Identities = 55/201 (27%), Positives = 103/201 (51%), Gaps = 2/201 (0%)
Query: 302 ERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVE-A 360
+ K++ +Q K ++Q+ E+ +L++K + QE Q + E + +++ V A
Sbjct: 855 QAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA 914
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKE 420
KKQ+ E+ + ++L+EEE++ ++ Q ER++ + L LE ++++ + L+LEK
Sbjct: 915 AKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV 974
Query: 421 IRE-KAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
E K +K E D+ + ++ LE +I D E+ +K + L KLK K E+
Sbjct: 975 TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHES 1034
Query: 480 NVSRDPSRLYKPTKGWEERTK 500
+S RL K K +E K
Sbjct: 1035 MISELEVRLKKEEKSRQELEK 1055
Score = 63.5 bits (153), Expect = 4e-10
Identities = 95/477 (19%), Positives = 210/477 (44%), Gaps = 65/477 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRK 118
+QK+N + K +R E+ +N + + ++ N + + L + + KL
Sbjct: 1329 RQKLNVSTK---LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 119 TERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE-MMEEIENAINTFKEEQRLI- 176
T A +++ + ++ L Q ++ D +EK + + +E+++ + +++L+
Sbjct: 1386 TVEA-LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444
Query: 177 --------YEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPST 228
+++L+ EEK +++ + + + A EK +A+S +++ +
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA-----REKETKALSLARALEEALEAK 1499
Query: 229 LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQ 288
EE+ K L+ + D +N ++ + T MEE+ L + +DE+Q
Sbjct: 1500 --EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE-ELEDELQ 1556
Query: 289 QHE----KWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQ 344
E + AL+ + + +Q + ++KR ++ + + +
Sbjct: 1557 ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQL--------------QRQLHEYE 1602
Query: 345 KQKEEQRKKQKLAVEAWKKQ----KSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLL 400
+ E++RK++ LA A KK K +E+ A + +EE K+ + + + + F+ +L
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL- 1661
Query: 401 LESYTQQKKEQEEFLRLEKEIREKAEKAE------KRKNAADEISRFQERDLHKLEL--- 451
+ ++E KE +KA+ E + AA E +R ++ DL K EL
Sbjct: 1662 ----EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR-KQADLEKEELAEE 1716
Query: 452 ---KILDRQAKEDEKSQKQRRLAKLKEKVE---NNVSRDPSRLYKPTKGWEERTKKI 502
+ R A +DEK + + R+A+L+E++E N+ R+ K T+ E+ + ++
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/398 (20%), Positives = 167/398 (41%), Gaps = 57/398 (14%)
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEK-------LREMMEEIENAI 166
+ +++ E K +++ K N +K+L+ + + + +++ L EE+ +
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 167 NTFKEEQRLIYEEL---IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDK 223
K+E I E+ ++EE+ +L A +K+ L E + A K+ ++K
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 224 VTPST----LPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHL 279
VT L +E+L D QN NK + +EE + L
Sbjct: 974 VTAEAKIKKLEDEILVM-----------------DDQN-----NKLSKERKLLEERISDL 1011
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
+E ++ K K E +++ K+++ R+E+ KLK K + FH +
Sbjct: 1012 TTNLAEE-EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 340 QEDNQ------------KQKEEQRKKQKLAVEAWKKQKSIEMSMKC---ASQLKEEEEKE 384
D Q K++E Q +L E +K +++ + S L+E+ + E
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 385 KKHQKERQRQFK-LKLLLESYTQQKKEQEEFLRLEKEIREKAE-KAEKRKNAADEISRFQ 442
+ + + ++Q + L LE+ + ++ + ++E+R K E + K A DE +R
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENN 480
E + ++ K QA E E +++ + + K ++ N
Sbjct: 1191 EAQVQEMRQK--HAQAVE-ELTEQLEQFKRAKANLDKN 1225
Score = 45.4 bits (106), Expect = 1e-04
Identities = 88/453 (19%), Positives = 187/453 (41%), Gaps = 66/453 (14%)
Query: 60 QKVNQTKKAEF---VRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHS 116
++ N+ KAE V + + V +EK K + Q + + + LEELE++L
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA-LETQMEEMKTQ---LEELEDEL--- 1555
Query: 117 RKTERAKIQQQLAKIHNNVKKLQHQL-KDVKPTPDFVEKLREMMEEIENAINTFKEEQRL 175
+ TE AK++ ++ N++ L+ Q +D++ + E+ R ++ + T E++R
Sbjct: 1556 QATEDAKLRLEV-----NMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 176 IYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+K +L + + D+ G E K R + +++ D
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK--------------D 1656
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKG---------------------KPTFMEE 274
F++ L+ + +N K ++ K EE
Sbjct: 1657 FQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEE 1716
Query: 275 VLEHLPGKT--QDEVQQHEK---WYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKA 329
+ L G+ QDE ++ E ++ L E+ E++ K Q+ E++
Sbjct: 1717 LASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE 1776
Query: 330 DNTPVLFHNKQEDNQKQKEEQRKK---QKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKK 386
+T + ++ ++Q +E R K + AV++ K + K A QL+E+ E+E +
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA-QLEEQVEQEAR 1835
Query: 387 HQKE-----RQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRF 441
++ +Q+ KLK +L ++K E++ ++ + ++ +++ A+E S+
Sbjct: 1836 EKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQR 1895
Query: 442 QERDLHKLELKILDRQAKEDEKSQKQRRLAKLK 474
+ KL+ + LD + +E ++ K K
Sbjct: 1896 INANRRKLQ-RELDEATESNEAMGREVNALKSK 1927
Score = 44.7 bits (104), Expect = 2e-04
Identities = 73/427 (17%), Positives = 177/427 (41%), Gaps = 50/427 (11%)
Query: 63 NQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERA 122
N+ K+ E + + ++ + + Y + + R+ + ++ +++H +
Sbjct: 873 NELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932
Query: 123 KIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLRE--MMEEIENAINTFKEEQRLIY--- 177
+ + + ++ KK+ Q+ D++ + E R+ +E++ K E ++
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDD 992
Query: 178 --EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+L KE K +S ++ + E EKA K + + + +
Sbjct: 993 QNNKLSKERKLLEERISDLTTNL------AEEEEKAKNLTKLKNKHESM--------ISE 1038
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
E L++ ++ Q K++ K +G + E + L + + Q K +
Sbjct: 1039 LEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 296 KFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQK 355
+ A R + I QK + K++E + L QED ++ + K +K
Sbjct: 1091 ELQAALARLDDEI-------AQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1139
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL 415
+ ++ ++++ ++ L +++ K Q LK L+ T+ + Q + +
Sbjct: 1140 QKRDLGEELEALKTELE--DTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 416 RLE-----KEIREKAEKAEKRKNAADEISRFQERDLHKL--ELKILDRQAKEDEKSQKQR 468
R + +E+ E+ E+ ++ K D+ + E++ L EL++L QAK++ + +K++
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG-QAKQEVEHKKKK 1256
Query: 469 RLAKLKE 475
A+++E
Sbjct: 1257 LEAQVQE 1263
Score = 40.4 bits (93), Expect = 0.004
Identities = 105/518 (20%), Positives = 200/518 (38%), Gaps = 99/518 (19%)
Query: 61 KVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE 120
+V K+ + + EK K + +E D S F+ Q +D + + + L+ K +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRK---LEGDA-SDFHEQIADLQAQIAELKMQLAKKEEELQAA 1095
Query: 121 RAKIQQQLAKIHNNVKK----------LQHQL--------KDVKPTPDFVEKLREMMEEI 162
A++ ++A+ +N +KK LQ L K K D E+L + E+
Sbjct: 1096 LARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTEL 1155
Query: 163 ENAINTF--------KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRA 214
E+ +++ K EQ + + +E+T ++E + TE+ +
Sbjct: 1156 EDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF 1215
Query: 215 ISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQ----------------NF 258
+K +DK TL +E D L+ G A + +H+ +
Sbjct: 1216 KRAKANLDK-NKQTLEKENADLAGELRVLGQ---AKQEVEHKKKKLEAQVQELQSKCSDG 1271
Query: 259 VKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQK 318
+ R + K ++ +E + G + + K + +L + +++ ++ + + +QK
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 319 REEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR-----------KKQKL--------AVE 359
KL++ + L E+ + ++ +R K+KL A+E
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 360 AWKK--QKSIE-----MSMKCASQLKEEEEKEKKHQ-------------------KERQR 393
KK QK IE K A+ K E+ K + Q +++QR
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQR 1451
Query: 394 QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQ---ERDLHKLE 450
+F +LL E K +E R E E REK KA A +E + ER L+
Sbjct: 1452 KFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLK 1510
Query: 451 LKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRL 488
++ D + +D+ + L K K +E + ++L
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL 1548
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 17/154 (11%)
Query: 361 WKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFK----LKLLLESYTQQKKEQ---EE 413
W+ ++ ++ Q +E + KE + QK ++RQ K LK L + ++Q +E+ +E
Sbjct: 835 WRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQE 894
Query: 414 FLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAK- 472
L+ E E+ +AE+ R A + E LH++E ++ + + + + +++++A+
Sbjct: 895 QLQAETELYAEAEEMRVRLAAK---KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 473 ---LKEKV-ENNVSRDPSRLYKPTKGWEERTKKI 502
L+E++ E +R +L K T E + KK+
Sbjct: 952 MLDLEEQLEEEEAARQKLQLEKVTA--EAKIKKL 983
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 70.1 bits (170), Expect = 5e-12
Identities = 57/238 (23%), Positives = 123/238 (51%), Gaps = 17/238 (7%)
Query: 276 LEHLPGKTQDEVQQHEKWYQKFLALEE---RKKESIQIWKTKKQQKREEIFKLKEKADNT 332
L+ + K Q +V+++E W EE R++E IQ + K ++ +I + +EK
Sbjct: 271 LQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQ 330
Query: 333 PVLFHNKQEDNQKQKEEQ-RKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK------EK 385
H ++E ++Q+++ R+++K+ + K ++ E + +++E++EK E
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 386 KHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAE---KAEKRKNAADEISRFQ 442
Q+E+ R+ + K + + Q+KK +E+ +++IRE+ E + E++ +E+ + Q
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQ----DEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTK 500
E L ++E K+ + + K E+ +K +R + ++ E R L + K WE+ K
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Score = 68.2 bits (165), Expect = 2e-11
Identities = 93/436 (21%), Positives = 194/436 (44%), Gaps = 77/436 (17%)
Query: 62 VNQTKKAEFVRTAEKFKNQVINME-KDKHSHFYNQKSDFRIEHSMLEELE-NKLIHSRKT 119
+ + K + E ++N + + E K+K++ + R+ S E++ N RK
Sbjct: 192 IEKLTKERDAPSLELYRNTITDEELKEKNAELQEK---LRLVESEKSEIQLNVKDLKRKL 248
Query: 120 ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIE--NAINTFKEEQRLIY 177
ERA++ ++ +L +L+ V KL+ +EE E N +N +EE+
Sbjct: 249 ERAQLLLPQQQLQVEADRLGKELQSVSA------KLQAQVEENELWNLLNQQQEEKMWRQ 302
Query: 178 EELIKE--EKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
EE I+E EK EL + EK +R E++ +
Sbjct: 303 EEKIQEQEEKMCEQELKI-----------REQEEKMWRQ---------------EEKMHE 336
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
E+ +++ + ++ + K+R + + K EE + K Q+ Q+ E W Q
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEE-KMWRQEEKIREQDEKIQE--QEEEMWRQ 393
Query: 296 KFLALEERKKESIQIWKTKKQ---------QKREEIFKLKEKADNTPVLFHNKQED---- 342
+ E+ +K ++W+ +K+ ++ EE+++ +EK + +++E
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 343 NQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLE 402
+K +EE+ K Q+ + ++++ I+ E+EEK + +K +++ K + E
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQ----------EQEEKTWRQEKLLKQEEK---IWE 500
Query: 403 SYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDE 462
+ +++E+ E++++E+ EK +++ +E R QE L + E K+ Q +E
Sbjct: 501 QEEKMWRQEEKMWEQEEKMQEQEEKMQRQ----EEKMREQEVRLWQQEEKM---QEQEVR 553
Query: 463 KSQKQRRLAKLKEKVE 478
+ + RL KL +K E
Sbjct: 554 LQELEERLGKLGQKAE 569
Score = 65.9 bits (159), Expect = 9e-11
Identities = 48/226 (21%), Positives = 114/226 (50%), Gaps = 10/226 (4%)
Query: 284 QDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDN 343
Q E + K Q A + + E ++W QQ+ E++++ +EK ++
Sbjct: 261 QVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKI 320
Query: 344 QKQKEEQ-RKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLE 402
++Q+E+ R+++K+ + K ++ + + +++E+EEK ++ +++ RQ + + E
Sbjct: 321 REQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEK--IRE 378
Query: 403 SYTQQKKEQEEFLRLEKEIREKAEK-------AEKRKNAADEISRFQERDLHKLELKILD 455
+ ++++EE R E++IRE+ EK EK+ DE R QE ++ + E KI +
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 456 RQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKK 501
+ ++ +K R + + ++ E + ++ + + +E+ +K
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/292 (17%), Positives = 120/292 (41%), Gaps = 53/292 (18%)
Query: 50 IRPFHLQNWKQKVNQTKKAEFVRTAE--------KFKNQVINMEKDKHSHFYNQKSDFRI 101
IR + W+Q+ ++ E +R E K + Q + +++ + Q+ R
Sbjct: 320 IREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-REQEEKMWRQEEKIRE 378
Query: 102 EHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEE 161
+ ++E E ++ + R + +++ K+ KK++ Q + ++ + + + E + E
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 162 IENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPV 221
+E + +E+ R + E++ +EE+ + I R+ + + EK +R
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKI---QEQEEKTWRQ------- 488
Query: 222 DKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPG 281
EK L+Q + W+ + K EE +
Sbjct: 489 ---------------EKLLKQ---EEKIWEQEE-------------KMWRQEEKMWEQEE 517
Query: 282 KTQDEVQQHEKWYQKFLALEER---KKESIQIWKTKKQQKREEIFKLKEKAD 330
K Q++ ++ ++ +K E R ++E +Q + + Q+ E + KL +KA+
Sbjct: 518 KMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 70.1 bits (170), Expect = 5e-12
Identities = 57/238 (23%), Positives = 123/238 (51%), Gaps = 17/238 (7%)
Query: 276 LEHLPGKTQDEVQQHEKWYQKFLALEE---RKKESIQIWKTKKQQKREEIFKLKEKADNT 332
L+ + K Q +V+++E W EE R++E IQ + K ++ +I + +EK
Sbjct: 271 LQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQ 330
Query: 333 PVLFHNKQEDNQKQKEEQ-RKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEK------EK 385
H ++E ++Q+++ R+++K+ + K ++ E + +++E++EK E
Sbjct: 331 EEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEM 390
Query: 386 KHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAE---KAEKRKNAADEISRFQ 442
Q+E+ R+ + K + + Q+KK +E+ +++IRE+ E + E++ +E+ + Q
Sbjct: 391 WRQEEKIREQEEKRQEKMWRQEKKMREQ----DEKIREQEEEMWRQEEKIRELEEMMQDQ 446
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTK 500
E L ++E K+ + + K E+ +K +R + ++ E R L + K WE+ K
Sbjct: 447 EEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Score = 68.2 bits (165), Expect = 2e-11
Identities = 93/436 (21%), Positives = 194/436 (44%), Gaps = 77/436 (17%)
Query: 62 VNQTKKAEFVRTAEKFKNQVINME-KDKHSHFYNQKSDFRIEHSMLEELE-NKLIHSRKT 119
+ + K + E ++N + + E K+K++ + R+ S E++ N RK
Sbjct: 192 IEKLTKERDALSLELYRNTITDEELKEKNAELQEK---LRLVESEKSEIQLNVKDLKRKL 248
Query: 120 ERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIE--NAINTFKEEQRLIY 177
ERA++ ++ +L +L+ V KL+ +EE E N +N +EE+
Sbjct: 249 ERAQLLLPQQQLQVEADRLGKELQSVSA------KLQAQVEENELWNLLNQQQEEKMWRQ 302
Query: 178 EELIKE--EKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
EE I+E EK EL + EK +R E++ +
Sbjct: 303 EEKIQEQEEKMCEQELKI-----------REQEEKMWRQ---------------EEKMHE 336
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
E+ +++ + ++ + K+R + + K EE + K Q+ Q+ E W Q
Sbjct: 337 QEEKIREQEDKMWRQEEKIREQEEKIREQEE-KMWRQEEKIREQDEKIQE--QEEEMWRQ 393
Query: 296 KFLALEERKKESIQIWKTKKQ---------QKREEIFKLKEKADNTPVLFHNKQED---- 342
+ E+ +K ++W+ +K+ ++ EE+++ +EK + +++E
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 343 NQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLE 402
+K +EE+ K Q+ + ++++ I+ E+EEK + +K +++ K + E
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQEEKIQ----------EQEEKTWRQEKLLKQEEK---IWE 500
Query: 403 SYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDE 462
+ +++E+ E++++E+ EK +++ +E R QE L + E K+ Q +E
Sbjct: 501 QEEKMWRQEEKMWEQEEKMQEQEEKMQRQ----EEKMREQEVRLWQQEEKM---QEQEVR 553
Query: 463 KSQKQRRLAKLKEKVE 478
+ + RL KL +K E
Sbjct: 554 LQELEERLGKLGQKAE 569
Score = 65.9 bits (159), Expect = 9e-11
Identities = 48/226 (21%), Positives = 114/226 (50%), Gaps = 10/226 (4%)
Query: 284 QDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDN 343
Q E + K Q A + + E ++W QQ+ E++++ +EK ++
Sbjct: 261 QVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKI 320
Query: 344 QKQKEEQ-RKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLE 402
++Q+E+ R+++K+ + K ++ + + +++E+EEK ++ +++ RQ + + E
Sbjct: 321 REQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEK--IRE 378
Query: 403 SYTQQKKEQEEFLRLEKEIREKAEK-------AEKRKNAADEISRFQERDLHKLELKILD 455
+ ++++EE R E++IRE+ EK EK+ DE R QE ++ + E KI +
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 456 RQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKK 501
+ ++ +K R + + ++ E + ++ + + +E+ +K
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEK 484
Score = 41.2 bits (95), Expect = 0.002
Identities = 52/292 (17%), Positives = 120/292 (41%), Gaps = 53/292 (18%)
Query: 50 IRPFHLQNWKQKVNQTKKAEFVRTAE--------KFKNQVINMEKDKHSHFYNQKSDFRI 101
IR + W+Q+ ++ E +R E K + Q + +++ + Q+ R
Sbjct: 320 IREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-REQEEKMWRQEEKIRE 378
Query: 102 EHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEE 161
+ ++E E ++ + R + +++ K+ KK++ Q + ++ + + + E + E
Sbjct: 379 QDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 162 IENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPV 221
+E + +E+ R + E++ +EE+ + I R+ + + EK +R
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKI---QEQEEKTWRQ------- 488
Query: 222 DKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPG 281
EK L+Q + W+ + K EE +
Sbjct: 489 ---------------EKLLKQ---EEKIWEQEE-------------KMWRQEEKMWEQEE 517
Query: 282 KTQDEVQQHEKWYQKFLALEER---KKESIQIWKTKKQQKREEIFKLKEKAD 330
K Q++ ++ ++ +K E R ++E +Q + + Q+ E + KL +KA+
Sbjct: 518 KMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAE 569
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 70.1 bits (170), Expect = 5e-12
Identities = 119/513 (23%), Positives = 211/513 (41%), Gaps = 84/513 (16%)
Query: 60 QKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKL---IHS 116
+ + Q K+ E V+ EK + + M + + + + + + E L +
Sbjct: 2419 ENILQEKEQEKVQMKEK-SSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVEC 2477
Query: 117 RKTERAKIQQQLAKIHNNVKKLQHQLKD-VKPTPDFVEKLREMMEEIENAINTFKEEQRL 175
+ E+A++ Q L + NN LQ + ++ D +KL + EEI N +++++L
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQL 2537
Query: 176 IYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLD 235
+ ++LS + + W N E + K+ V + ++L ++ L+
Sbjct: 2538 V------------SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASL-QDTLE 2584
Query: 236 FEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQ 295
+ + + D +FV+ NK K T ++ + + KT E+Q+ +
Sbjct: 2585 VLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTA-ELQEELSGEK 2643
Query: 296 KFLA------LEERKKESIQIWKT--------------------KKQQKREEIFKLK--- 326
LA LEE K Q+ + K+ + REEI + +
Sbjct: 2644 NRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRL 2703
Query: 327 ---EKADNTPVLFHNKQEDNQKQ--------KEEQRKKQKLAVEAWKKQKS-IEMSMKCA 374
EK +L NKQ + + Q KEE QKL ++ K K + S+K
Sbjct: 2704 HEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKAT 2763
Query: 375 SQLKEEEEKEKKH--------QKERQR-QFKLKLLLESYTQQKKEQEEFLRLEKEIREKA 425
+Q+ EE +K K +KE +R Q K+KLL++S Q ++E+E L+KE+ +
Sbjct: 2764 TQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKE---ILQKELSQLQ 2820
Query: 426 EKAEKRKNAADEISRFQERDLHKLELK-ILDRQAKE-DEKSQK-------QRRLAKLKEK 476
EK+K ++ E ELK L+ + KE DE K +L K KE
Sbjct: 2821 AAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 477 VENNVSRDPSRLYKPTKGWEERTKKIGPTGSGP 509
+E V+ S + +K + +GP GP
Sbjct: 2881 LETQVAHLCS---QQSKQDSRGSPLLGPVVPGP 2910
Score = 49.3 bits (116), Expect = 9e-06
Identities = 91/412 (22%), Positives = 179/412 (43%), Gaps = 76/412 (18%)
Query: 154 KLREMMEEIENAINTFKEEQRLIYE---ELIKEEKTTN---NELSAISRKIDTWALGNSE 207
+L+ +E++ +N F+E Q + + ELI++EK N +EL + + D + +
Sbjct: 300 RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTA 359
Query: 208 TEKAFRAISSKVPVDKVTPST----LPEEVLDFEK-FLQQTGGRQGAWDDYDH------- 255
E+ + ++ + + + L +++ + EK F ++ +Q ++ D
Sbjct: 360 LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKA 419
Query: 256 ---QNFVKVRNKHK------GKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFL-------- 298
Q + +N H K T +++ LE+ + + ++ + E+ +Q
Sbjct: 420 RLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRR 479
Query: 299 ALEERKKESIQIWKTKKQQKREEIFKLKE-------------------KADNTP---VLF 336
++EE KKE+ + K+ +QK E+ L+ KA NT +L
Sbjct: 480 SMEEMKKEN-NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLR 538
Query: 337 HNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQL--KEEEEKEKKHQKERQRQ 394
+++ NQ++ +K KLAV +KQ+ C+ L K E E+ + K + +
Sbjct: 539 DLQEKINQQENSLTLEKLKLAVADLEKQRD------CSQDLLKKREHHIEQLNDKLSKTE 592
Query: 395 FKLKLLLESYTQQKKEQEEFLRLEKEIRE--KAEKAEKRKNAADEISRFQERDLHKLELK 452
+ K LL + +KKE EE L+ EK + K+E + E Q + ++ LE
Sbjct: 593 KESKALLSALELKKKEYEE-LKEEKTLFSCWKSENEKLLTQMESEKENLQSK-INHLETC 650
Query: 453 ILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYK--PTKGWEERTKKI 502
+ +Q K E +++ R L E N+S + L+ +K E T+K+
Sbjct: 651 LKTQQIKSHEYNERVRTL----EMDRENLSVEIRNLHNVLDSKSVEVETQKL 698
Score = 43.5 bits (101), Expect = 5e-04
Identities = 80/410 (19%), Positives = 176/410 (42%), Gaps = 50/410 (12%)
Query: 54 HLQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKS-DFRIEHSMLEELE-N 111
HLQ Q + + +A + E +NQ+ + K+K +S R+ S E+L +
Sbjct: 2032 HLQEKLQSLEKDSQALSLTKCE-LENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090
Query: 112 KLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEK----LREMMEEIENAIN 167
K + + E+ + +L+ V +L+ ++ ++ + EK + E ++E E +
Sbjct: 2091 KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKEREREND 2150
Query: 168 TFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKV-PVDKVTP 226
+ K++ + EL E+ N EL + + + +T+ A S KV +D VT
Sbjct: 2151 SLKDKVENLERELQMSEE--NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVT- 2207
Query: 227 STLPEEVLDFEKFLQQTGGRQGAWD----------DYDHQNFVKVRNKHKGKPTFMEEVL 276
L E + K +Q+ G+ D + Q ++++ + K ++ L
Sbjct: 2208 --LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265
Query: 277 EHLPGKT------QDEVQQHEKWYQKFLALEERKKESIQIWKTK---KQQKREEIFKLKE 327
+ L Q+ ++ E+ + E + + SI+ + + ++K+ + + +
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 328 KADNTPVLFHNKQEDNQKQKEEQRKKQK-LAVEAWKKQKSIE---------------MSM 371
++++ L + E+ +++ E R Q+ A+EA + +E + +
Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL 2385
Query: 372 KCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQ--QKKEQEEFLRLEK 419
+ E+E + QKE++R +L+++ S+ Q+KEQE+ EK
Sbjct: 2386 DVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEK 2435
Score = 42.7 bits (99), Expect = 8e-04
Identities = 94/518 (18%), Positives = 204/518 (39%), Gaps = 110/518 (21%)
Query: 61 KVNQTKKAEF---VRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSR 117
K Q K E+ VRT E + + ++ H+ ++ + + EL+ K S
Sbjct: 652 KTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD 711
Query: 118 KTERAKIQQQLAK---IHNNVKKLQHQL---------KD--VKPTPDFVEKLREMMEEIE 163
+ + +I+ K + V+ L+H+L KD + E LR++++ +
Sbjct: 712 QKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKD 771
Query: 164 NAINTFKEEQRLI------------YEELIKEEKTTNNELSAISRKIDTWALGNSETEKA 211
++ T ++ QR + + +I E+ + +E S + D ++ +
Sbjct: 772 ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
Query: 212 FRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTF 271
++ + K S L ++ E+ +Q G + +N +K H+ +F
Sbjct: 832 VDSLEFSLESQKQMNSDLQKQC---EELVQIKGEIE--------ENLMKAEQMHQ---SF 877
Query: 272 MEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLK----- 326
+ E + + K Q++ H+ + L+ E K++ +Q+ K + ++ EI +LK
Sbjct: 878 VAETSQRI-SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHL 936
Query: 327 -----------------EKADNTPVLFHNKQEDNQKQKE--------------------- 348
EK + + ++ NK+E + +E
Sbjct: 937 LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQK 996
Query: 349 --------EQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLL 400
++R+K + KQ+ + + +C E+ +K++ +++ KL+ L
Sbjct: 997 SESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECL 1056
Query: 401 LESYT----QQKKE----QEEFLRLEKEIREKAEKAEKR-KNAADEISRFQERDLHKLEL 451
L T +K E +E F + +E K AE+R +N E+ Q+ L
Sbjct: 1057 LNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQ----ALRS 1112
Query: 452 KILDRQ-AKEDEKSQKQRRLAKLKEKVENNVSRDPSRL 488
++ D Q + E ++ + LKE+ +N + ++ + L
Sbjct: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEE-QNKMQKEVNDL 1149
Score = 42.0 bits (97), Expect = 0.001
Identities = 90/463 (19%), Positives = 182/463 (39%), Gaps = 71/463 (15%)
Query: 75 EKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLE-ELE----NKLIHSRKTERAK-----I 124
+ +K + +++E + S ++K+ E LE +LE KL + E + +
Sbjct: 1891 DSWKERFLDVENEL-SRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949
Query: 125 QQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEE 184
+++L+ + + +L+ +L + +++L E M+E + + + E + E
Sbjct: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 185 KTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEK----FL 240
K L +S + + ++ +++ +T L ++ K +
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069
Query: 241 QQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLP--GKTQDEVQQHEKWYQKF- 297
+++ Q + D++ N K + E E TQ+EV Q + +K
Sbjct: 2070 KESESLQARLSESDYEKL----NVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLR 2125
Query: 298 LALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQE---------DNQKQKE 348
+ +E +K+ + I + K+++RE LK+K +N +E +N K +
Sbjct: 2126 VRIEADEKKQLHIAEKLKEREREND-SLKDKVENLERELQMSEENQELVILDAENSKAEV 2184
Query: 349 EQRK-----------------------KQKLAVEAWKKQKSIEMSMKCASQLK---EEEE 382
E K K+ L + +KQ + K S K EE+E
Sbjct: 2185 ETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKE 2244
Query: 383 KEKKHQKERQR------QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAAD 436
+ + KE + Q +LK L E+ +QE E+ + E+ + +N+ +
Sbjct: 2245 QAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIE 2304
Query: 437 EISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVEN 479
++ E D K +L +L +Q KE E LK +VEN
Sbjct: 2305 KLRARLEAD-EKKQLCVL-QQLKESE-----HHADLLKGRVEN 2340
Score = 36.2 bits (82), Expect = 0.076
Identities = 31/127 (24%), Positives = 66/127 (51%), Gaps = 16/127 (12%)
Query: 357 AVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQ-RQFKLKLLLESYTQQKK----EQ 411
A+E WK+ + + +++E E + K +KE+Q RQF+L L + +QK+ E+
Sbjct: 4 ALEEWKEG----LPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEK 59
Query: 412 EEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLA 471
E L++E + E E + +IS H+L++K +E + + ++++
Sbjct: 60 TEGTNLKRENQRLMEICESLEKTKQKIS-------HELQVKESQVNFQEGQLNSGKKQIE 112
Query: 472 KLKEKVE 478
KL+++++
Sbjct: 113 KLEQELK 119
Score = 32.7 bits (73), Expect = 0.84
Identities = 65/318 (20%), Positives = 130/318 (40%), Gaps = 36/318 (11%)
Query: 185 KTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTG 244
K T+NE + I+ + + SK+ + +V T E ++ EK + +
Sbjct: 1777 KETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELK 1836
Query: 245 GRQGAWDDY------DHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEV-----QQHEKW 293
+ DHQ ++ +G + +E H +++++ + ++ W
Sbjct: 1837 KENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEM---HADKSSREDIGDNVAKVNDSW 1893
Query: 294 YQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKK 353
++FL +E E +I K + E ++ +AD V Q + +++ K
Sbjct: 1894 KERFLDVEN---ELSRIRSEKASIEHEALYL---EADLEVV-----QTEKLCLEKDNENK 1942
Query: 354 QKLAVEAWKKQKSIEMSMKCASQLKEE-EEKEKKHQKERQRQFKLKLLLESYTQQKKEQE 412
QK+ V +++ S+ S + +QL+ E + KK Q K+K E + + Q
Sbjct: 1943 QKVIV-CLEEELSVVTSER--NQLRGELDTMSKKTTALDQLSEKMK---EKTQELESHQS 1996
Query: 413 EFLRL----EKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQR 468
E L E E++EK E + + E+ + + KL+ D QA K + +
Sbjct: 1997 ECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELEN 2056
Query: 469 RLAKLKEKVENNVSRDPS 486
++A+L ++ E V S
Sbjct: 2057 QIAQLNKEKELLVKESES 2074
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 69.3 bits (168), Expect = 8e-12
Identities = 45/196 (22%), Positives = 108/196 (55%), Gaps = 20/196 (10%)
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
PG +++QQ EK L E R+ E + ++++++EE+ + +E+ + +
Sbjct: 713 PGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE------ILRRQ 766
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
QE+ +K++EE+ ++ EA ++Q+ E++++ ++ EE+E++ Q+E R+ +
Sbjct: 767 QEEERKRREEEELARRKQEEALRRQREQEIALR-----RQREEEERQQQEEALRRLE--- 818
Query: 400 LLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAK 459
++++E+EE + E+ +R++ E+A K +E R E + ++E + + +
Sbjct: 819 ------ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE 872
Query: 460 EDEKSQKQRRLAKLKE 475
E+E+ +K+ + + KE
Sbjct: 873 EEERKRKELEVQRQKE 888
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/110 (29%), Positives = 63/110 (57%), Gaps = 5/110 (4%)
Query: 372 KCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI-REKAEKAEK 430
K + +E E + K+ ++ER+RQ +L+ E ++++E+E R E+E+ R K E+A +
Sbjct: 730 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 789
Query: 431 RKNAADEISRFQ----ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEK 476
R+ + R Q ER + L+ L+ + +E+E+ +KQ L + +E+
Sbjct: 790 RQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEE 839
Score = 43.1 bits (100), Expect = 6e-04
Identities = 25/104 (24%), Positives = 63/104 (60%), Gaps = 5/104 (4%)
Query: 376 QLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAA 435
QL++ E+ + ++ +R+ +++ E +++K QEE R ++EI + ++ E+++
Sbjct: 719 QLQQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREE 776
Query: 436 DEISRFQERDL--HKLELKILDRQAKEDEKSQKQRR-LAKLKEK 476
+E++R ++ + + E +I R+ +E+E+ Q+Q L +L+E+
Sbjct: 777 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 820
Score = 41.6 bits (96), Expect = 0.002
Identities = 76/416 (18%), Positives = 168/416 (40%), Gaps = 81/416 (19%)
Query: 118 KTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIY 177
K + AK++Q+ + K+ + + K E+LR EEI + +EE+R
Sbjct: 725 KAKAAKLEQERREAEMRAKREEEERKRQ-------EELRRQQEEI---LRRQQEEERKRR 774
Query: 178 EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFE 237
EE EE + A+ R+ E E A R + EE E
Sbjct: 775 EE---EELARRKQEEALRRQ--------REQEIALRRQREE------------EERQQQE 811
Query: 238 KFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKF 297
+ L++ R+ ++ Q + +R + + + E E ++ ++ E+ +
Sbjct: 812 EALRRLEERRREEEERRKQEEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 870
Query: 298 LALEERKKESIQIWKTK-----KQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRK 352
EERK++ +++ + K +QQ++E + +L+ Q+Q+++Q
Sbjct: 871 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ-----------------QQQQQQQLA 913
Query: 353 KQKL-AVEAWKKQKSIE-------MSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESY 404
+ KL + W +Q + +S+ +L+EE E++ + ++ RQ++ +K L +
Sbjct: 914 QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 973
Query: 405 TQQKKE-------------QEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLEL 451
QQ+++ + L +++E + +K ++++ + +R + L
Sbjct: 974 QQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHT 1033
Query: 452 KILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIGPTGS 507
I + + + L + +N S + W++ K++GP S
Sbjct: 1034 SIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNM----GFWDDAVKEVGPRNS 1085
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 69.3 bits (168), Expect = 8e-12
Identities = 45/196 (22%), Positives = 108/196 (55%), Gaps = 20/196 (10%)
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
PG +++QQ EK L E R+ E + ++++++EE+ + +E+ + +
Sbjct: 740 PGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE------ILRRQ 793
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
QE+ +K++EE+ ++ EA ++Q+ E++++ ++ EE+E++ Q+E R+ +
Sbjct: 794 QEEERKRREEEELARRKQEEALRRQREQEIALR-----RQREEEERQQQEEALRRLE--- 845
Query: 400 LLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAK 459
++++E+EE + E+ +R++ E+A K +E R E + ++E + + +
Sbjct: 846 ------ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE 899
Query: 460 EDEKSQKQRRLAKLKE 475
E+E+ +K+ + + KE
Sbjct: 900 EEERKRKELEVQRQKE 915
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/110 (29%), Positives = 63/110 (57%), Gaps = 5/110 (4%)
Query: 372 KCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI-REKAEKAEK 430
K + +E E + K+ ++ER+RQ +L+ E ++++E+E R E+E+ R K E+A +
Sbjct: 757 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 816
Query: 431 RKNAADEISRFQ----ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEK 476
R+ + R Q ER + L+ L+ + +E+E+ +KQ L + +E+
Sbjct: 817 RQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEE 866
Score = 43.1 bits (100), Expect = 6e-04
Identities = 25/104 (24%), Positives = 63/104 (60%), Gaps = 5/104 (4%)
Query: 376 QLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAA 435
QL++ E+ + ++ +R+ +++ E +++K QEE R ++EI + ++ E+++
Sbjct: 746 QLQQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREE 803
Query: 436 DEISRFQERDL--HKLELKILDRQAKEDEKSQKQRR-LAKLKEK 476
+E++R ++ + + E +I R+ +E+E+ Q+Q L +L+E+
Sbjct: 804 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 847
Score = 41.6 bits (96), Expect = 0.002
Identities = 76/416 (18%), Positives = 168/416 (40%), Gaps = 81/416 (19%)
Query: 118 KTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIY 177
K + AK++Q+ + K+ + + K E+LR EEI + +EE+R
Sbjct: 752 KAKAAKLEQERREAEMRAKREEEERKRQ-------EELRRQQEEI---LRRQQEEERKRR 801
Query: 178 EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFE 237
EE EE + A+ R+ E E A R + EE E
Sbjct: 802 EE---EELARRKQEEALRRQ--------REQEIALRRQREE------------EERQQQE 838
Query: 238 KFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKF 297
+ L++ R+ ++ Q + +R + + + E E ++ ++ E+ +
Sbjct: 839 EALRRLEERRREEEERRKQEEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 897
Query: 298 LALEERKKESIQIWKTK-----KQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRK 352
EERK++ +++ + K +QQ++E + +L+ Q+Q+++Q
Sbjct: 898 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ-----------------QQQQQQQLA 940
Query: 353 KQKL-AVEAWKKQKSIE-------MSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESY 404
+ KL + W +Q + +S+ +L+EE E++ + ++ RQ++ +K L +
Sbjct: 941 QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 1000
Query: 405 TQQKKE-------------QEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLEL 451
QQ+++ + L +++E + +K ++++ + +R + L
Sbjct: 1001 QQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHT 1060
Query: 452 KILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIGPTGS 507
I + + + L + +N S + W++ K++GP S
Sbjct: 1061 SIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNM----GFWDDAVKEVGPRNS 1112
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 69.3 bits (168), Expect = 8e-12
Identities = 45/196 (22%), Positives = 108/196 (55%), Gaps = 20/196 (10%)
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
PG +++QQ EK L E R+ E + ++++++EE+ + +E+ + +
Sbjct: 719 PGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE------ILRRQ 772
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
QE+ +K++EE+ ++ EA ++Q+ E++++ ++ EE+E++ Q+E R+ +
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALR-----RQREEEERQQQEEALRRLE--- 824
Query: 400 LLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAK 459
++++E+EE + E+ +R++ E+A K +E R E + ++E + + +
Sbjct: 825 ------ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE 878
Query: 460 EDEKSQKQRRLAKLKE 475
E+E+ +K+ + + KE
Sbjct: 879 EEERKRKELEVQRQKE 894
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/110 (29%), Positives = 63/110 (57%), Gaps = 5/110 (4%)
Query: 372 KCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI-REKAEKAEK 430
K + +E E + K+ ++ER+RQ +L+ E ++++E+E R E+E+ R K E+A +
Sbjct: 736 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 795
Query: 431 RKNAADEISRFQ----ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEK 476
R+ + R Q ER + L+ L+ + +E+E+ +KQ L + +E+
Sbjct: 796 RQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEE 845
Score = 43.1 bits (100), Expect = 6e-04
Identities = 25/104 (24%), Positives = 63/104 (60%), Gaps = 5/104 (4%)
Query: 376 QLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAA 435
QL++ E+ + ++ +R+ +++ E +++K QEE R ++EI + ++ E+++
Sbjct: 725 QLQQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 436 DEISRFQERDL--HKLELKILDRQAKEDEKSQKQRR-LAKLKEK 476
+E++R ++ + + E +I R+ +E+E+ Q+Q L +L+E+
Sbjct: 783 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826
Score = 41.6 bits (96), Expect = 0.002
Identities = 76/416 (18%), Positives = 168/416 (40%), Gaps = 81/416 (19%)
Query: 118 KTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIY 177
K + AK++Q+ + K+ + + K E+LR EEI + +EE+R
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQ-------EELRRQQEEI---LRRQQEEERKRR 780
Query: 178 EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFE 237
EE EE + A+ R+ E E A R + EE E
Sbjct: 781 EE---EELARRKQEEALRRQ--------REQEIALRRQREE------------EERQQQE 817
Query: 238 KFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKF 297
+ L++ R+ ++ Q + +R + + + E E ++ ++ E+ +
Sbjct: 818 EALRRLEERRREEEERRKQEEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876
Query: 298 LALEERKKESIQIWKTK-----KQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRK 352
EERK++ +++ + K +QQ++E + +L+ Q+Q+++Q
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ-----------------QQQQQQQLA 919
Query: 353 KQKL-AVEAWKKQKSIE-------MSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESY 404
+ KL + W +Q + +S+ +L+EE E++ + ++ RQ++ +K L +
Sbjct: 920 QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 979
Query: 405 TQQKKE-------------QEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLEL 451
QQ+++ + L +++E + +K ++++ + +R + L
Sbjct: 980 QQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHT 1039
Query: 452 KILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIGPTGS 507
I + + + L + +N S + W++ K++GP S
Sbjct: 1040 SIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNM----GFWDDAVKEVGPRNS 1091
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 69.3 bits (168), Expect = 8e-12
Identities = 45/196 (22%), Positives = 108/196 (55%), Gaps = 20/196 (10%)
Query: 280 PGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
PG +++QQ EK L E R+ E + ++++++EE+ + +E+ + +
Sbjct: 719 PGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEE------ILRRQ 772
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKL 399
QE+ +K++EE+ ++ EA ++Q+ E++++ ++ EE+E++ Q+E R+ +
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALR-----RQREEEERQQQEEALRRLE--- 824
Query: 400 LLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAK 459
++++E+EE + E+ +R++ E+A K +E R E + ++E + + +
Sbjct: 825 ------ERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHE 878
Query: 460 EDEKSQKQRRLAKLKE 475
E+E+ +K+ + + KE
Sbjct: 879 EEERKRKELEVQRQKE 894
Score = 50.1 bits (118), Expect = 5e-06
Identities = 32/110 (29%), Positives = 63/110 (57%), Gaps = 5/110 (4%)
Query: 372 KCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI-REKAEKAEK 430
K + +E E + K+ ++ER+RQ +L+ E ++++E+E R E+E+ R K E+A +
Sbjct: 736 KLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALR 795
Query: 431 RKNAADEISRFQ----ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEK 476
R+ + R Q ER + L+ L+ + +E+E+ +KQ L + +E+
Sbjct: 796 RQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEE 845
Score = 43.1 bits (100), Expect = 6e-04
Identities = 25/104 (24%), Positives = 63/104 (60%), Gaps = 5/104 (4%)
Query: 376 QLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAA 435
QL++ E+ + ++ +R+ +++ E +++K QEE R ++EI + ++ E+++
Sbjct: 725 QLQQLEKAKAAKLEQERREAEMRAKREE--EERKRQEELRRQQEEILRRQQEEERKRREE 782
Query: 436 DEISRFQERDL--HKLELKILDRQAKEDEKSQKQRR-LAKLKEK 476
+E++R ++ + + E +I R+ +E+E+ Q+Q L +L+E+
Sbjct: 783 EELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEER 826
Score = 41.6 bits (96), Expect = 0.002
Identities = 76/416 (18%), Positives = 168/416 (40%), Gaps = 81/416 (19%)
Query: 118 KTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIY 177
K + AK++Q+ + K+ + + K E+LR EEI + +EE+R
Sbjct: 731 KAKAAKLEQERREAEMRAKREEEERKRQ-------EELRRQQEEI---LRRQQEEERKRR 780
Query: 178 EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFE 237
EE EE + A+ R+ E E A R + EE E
Sbjct: 781 EE---EELARRKQEEALRRQ--------REQEIALRRQREE------------EERQQQE 817
Query: 238 KFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKF 297
+ L++ R+ ++ Q + +R + + + E E ++ ++ E+ +
Sbjct: 818 EALRRLEERRREEEERRKQEEL-LRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876
Query: 298 LALEERKKESIQIWKTK-----KQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRK 352
EERK++ +++ + K +QQ++E + +L+ Q+Q+++Q
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQ-----------------QQQQQQQLA 919
Query: 353 KQKL-AVEAWKKQKSIE-------MSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESY 404
+ KL + W +Q + +S+ +L+EE E++ + ++ RQ++ +K L +
Sbjct: 920 QMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 979
Query: 405 TQQKKE-------------QEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLEL 451
QQ+++ + L +++E + +K ++++ + +R + L
Sbjct: 980 QQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHT 1039
Query: 452 KILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPTKGWEERTKKIGPTGS 507
I + + + L + +N S + W++ K++GP S
Sbjct: 1040 SIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNM----GFWDDAVKEVGPRNS 1091
>gi|46049114 M-phase phosphoprotein 1 [Homo sapiens]
Length = 1780
Score = 68.6 bits (166), Expect = 1e-11
Identities = 103/442 (23%), Positives = 196/442 (44%), Gaps = 70/442 (15%)
Query: 96 KSDFRIEHSMLEELENKLIHSRKTERAKIQQQ--LAKIHNNVKKLQHQLKD-VKPTPDFV 152
K+ + ++LE + + HS K E+ ++++ + K+ N+K+ Q L+D VK T D
Sbjct: 1120 KAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLN 1179
Query: 153 EKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAF 212
K ++ EEI N ++ + L+ +L +EE+ TN + +T L + +
Sbjct: 1180 VKELKLKEEITQLTNNLQDMKHLL--QLKEEEEETNRQ--------ETEKLKEELSASSA 1229
Query: 213 RAISSKVPVDKVTP--STLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPT 270
R + K + + + L E++ D +K ++Q D D +K+ K K
Sbjct: 1230 RTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQ 1289
Query: 271 FMEEV----------LEHLPG-KTQDEVQQHEKWYQKF-----------LALEERKKESI 308
+E+ E L K ++ +QQ+E+ + + LEE+++ +
Sbjct: 1290 CSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQV 1349
Query: 309 ---QIWKTKKQQKRE---EIFKLKEKADNTPVLFH---NKQEDNQK---------QKEEQ 350
Q+ + K ++ E+ K KEK ++ + NK+ +N Q E Q
Sbjct: 1350 EQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQ 1409
Query: 351 RKKQKLAVEAWKKQKSIEMSMKCASQLKEEE----EKEKKHQKERQRQFKLKLLLESYTQ 406
+QK + ++K +E M +Q KE E ++ KK+ ++R+R FK + +E T
Sbjct: 1410 ESEQKYNAD---RKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTA 1466
Query: 407 QKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQK 466
Q E++ L+ +E R++ A + + A S Q+ + E++ L R E K +
Sbjct: 1467 QLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDN----EIEQLKRIISETSKIET 1522
Query: 467 QRRLAKLKEKVENNVSRDPSRL 488
Q + +K K S DP +L
Sbjct: 1523 Q--IMDIKPK--RISSADPDKL 1540
Score = 67.0 bits (162), Expect = 4e-11
Identities = 92/461 (19%), Positives = 207/461 (44%), Gaps = 56/461 (12%)
Query: 67 KAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQ 126
K + +RT + +Q+ N++ N + + ++ L+ L N + S++ + +IQ+
Sbjct: 948 KIDELRTLDSV-SQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQE 1006
Query: 127 QLAK--IHNNVKKLQHQLKDVKPTPDF----VEKLREMMEEIENAINTFKEEQRLIYE-- 178
+ H++++ + + K++ +E+L + +E+++ + +K+E + E
Sbjct: 1007 PNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKE 1066
Query: 179 -----ELIKEEKTT----NNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTL 229
+L+KE++T EL + +D E ++A ++ V K L
Sbjct: 1067 HKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKEL 1126
Query: 230 PEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQ 289
E +L+ +K ++ + + D + ++ + ++ ++E EHL QD V+
Sbjct: 1127 -ETILETQK-VECSHSAKLEQDILEKESIILKLERN------LKEFQEHL----QDSVKN 1174
Query: 290 HEKWYQKFLALEER----------KKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNK 339
+ K L L+E K +Q+ + +++ R+E KLKE+ + N
Sbjct: 1175 TKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNL 1234
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCAS------QLKEEEEKEKKHQKERQR 393
+ D Q+++E+ ++ +A K+ K ++ + ++K E ++KK+Q ++
Sbjct: 1235 KADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQEL 1294
Query: 394 QFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKI 453
K + + QQ KEQ ++E+ I ++ E+A K N ++I L + E
Sbjct: 1295 DMKQRTI-----QQLKEQLNNQKVEEAI-QQYERACKDLNVKEKIIEDMRMTLEEQEQTQ 1348
Query: 454 LDR----QAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYK 490
+++ +AK +E + L K KEK + +++ R K
Sbjct: 1349 VEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNK 1389
Score = 56.6 bits (135), Expect = 5e-08
Identities = 86/465 (18%), Positives = 191/465 (41%), Gaps = 67/465 (14%)
Query: 66 KKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQ 125
K ++ V ++++N+++ S + N D + ++EELEN ++ E +
Sbjct: 497 KSSQDVSLDSNSNSKILNVKRATIS-WENSLEDLMEDEDLVEELENAE-ETQNVETKLLD 554
Query: 126 QQLAKI---------HNNVKKLQHQLKDVKPT--PDFVEKLR---EMMEEIENAINTFKE 171
+ L K H +KL ++D+K + EKL ++ EE+ +
Sbjct: 555 EDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWA 614
Query: 172 EQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSET--EKAFRAISSKVPVDKVTPSTL 229
++ ++E + +E+ E + I +G +T E A ++KV ++ T
Sbjct: 615 QREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEEATACL- 673
Query: 230 PEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQ 289
L F + + +G +K + + K + + +++ L + + Q
Sbjct: 674 ---ELKFNQIKAELAKTKG--------ELIKTKEELKKRENESDSLIQELETSNKKIITQ 722
Query: 290 HEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEE 349
+++ ++ + + ++K+++I ++ K E FK +KAD + ++ +NK N+ +
Sbjct: 723 NQR-IKELINIIDQKEDTINEFQNLKSHM-ENTFKCNDKADTSSLIINNKLICNETVEVP 780
Query: 350 QRKKQKLAVEAWK-------------KQKSIEMSMKCASQLKEEEEK-------EKKHQK 389
+ K K+ E + K+ SI +S K+ EE E
Sbjct: 781 KDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVL 840
Query: 390 ERQRQFKLKLLLESYTQQKKEQEEFLRLEKEI----REKAEKAEKRKNAADEISRFQERD 445
+ + LL + K E+EE L K+I +E + +K + E+ + Q
Sbjct: 841 QENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQS-- 898
Query: 446 LHKLELKILDRQAKEDEKSQKQRRLAKLKEKVE-------NNVSR 483
++ I + ++ + +++ ++ KL ++E NNVS+
Sbjct: 899 --NYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQ 941
Score = 45.8 bits (107), Expect = 1e-04
Identities = 91/498 (18%), Positives = 195/498 (39%), Gaps = 61/498 (12%)
Query: 54 HLQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKL 113
H++N + ++ + + + N+ + + KD S +++ R+ + L++ E
Sbjct: 749 HMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERK--RVNENELQQDEPPA 806
Query: 114 IHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQ 173
+ I + K V+ +++D++ + E LR + IEN + KEE+
Sbjct: 807 KKGSIHVSSAITEDQKK-SEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEK 865
Query: 174 RLIYEELI----------KEEKTTNNELSAISRKID-------TWALGNSETEKAFRAIS 216
+ ++++ K+ T + E+ I D N E E+ +S
Sbjct: 866 AELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLS 925
Query: 217 SKVPVD--KVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRN--KHKGKPTFM 272
+++ +T + +++ + +T + D N + N + P
Sbjct: 926 NEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQ 985
Query: 273 EEVL--EHLPGKTQDEVQQHE-----KWYQKFLALEERKKESIQIWKTKKQQKRE----- 320
++L ++L K E + E ++ A+ E KE ++ K Q E
Sbjct: 986 LDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQI 1045
Query: 321 -----EIFKLKEKADNTPVLFHNKQEDNQKQKEE--QRKKQKLAVEAWKKQKSIEMSMKC 373
E+ K++ + H Q+D K+KE Q+ K++L ++K++ + ++
Sbjct: 1046 EKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEEL------QEKNVTLDVQI 1099
Query: 374 ASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKN 433
++ + + Q + K+K L QK E +LE++I EK K +
Sbjct: 1100 QHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLER 1159
Query: 434 AADEISRFQE---------RDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRD 484
+ FQE +DL+ ELK+ + + Q + L +LKE+ E ++
Sbjct: 1160 ---NLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQE 1216
Query: 485 PSRLYKPTKGWEERTKKI 502
+L + RT+ +
Sbjct: 1217 TEKLKEELSASSARTQNL 1234
Score = 30.8 bits (68), Expect = 3.2
Identities = 72/407 (17%), Positives = 146/407 (35%), Gaps = 70/407 (17%)
Query: 55 LQNWKQKVNQTKKAEF---------VRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSM 105
LQ +QK N +K + AE +N+ + + F+ Q+++ I +
Sbjct: 1408 LQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQ 1467
Query: 106 LEELEN--------------------KLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDV 145
L E ++ K + S ++ +QL +I + K++ Q+ D+
Sbjct: 1468 LTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDI 1527
Query: 146 KPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGN 205
KP + I +A + +L E L + + N++ S +D
Sbjct: 1528 KP------------KRISSA-----DPDKLQTEPLSTSFEISRNKIEDGSVVLD------ 1564
Query: 206 SETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKH 265
S +V + + P+ L+ + Q VK+
Sbjct: 1565 ----------SCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKAR 1614
Query: 266 KGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKL 325
K K MEE L K +++ + KF ++R + K + ++ + L
Sbjct: 1615 KRKSNEMEEDLV----KCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSL 1670
Query: 326 KEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEK 385
+ +A V K+++ QK + ++ K +K IE +M + E KE
Sbjct: 1671 RSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIE-TMSSSKLSNVEASKEN 1729
Query: 386 KHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRK 432
Q +R K KL + + + ++++++E + KR+
Sbjct: 1730 VSQPKRA---KRKLYTSEISSPIDISGQVILMDQKMKESDHQIIKRR 1773
>gi|31377611 coiled-coil domain containing 148 [Homo sapiens]
Length = 591
Score = 68.2 bits (165), Expect = 2e-11
Identities = 92/426 (21%), Positives = 189/426 (44%), Gaps = 48/426 (11%)
Query: 106 LEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQ-LKDVKPTPDFVEKLREMMEEIEN 164
L E +L + T + + ++ ++K QH L+ P +F +++EE++
Sbjct: 108 LTNFEQELSEQQCTYLKNVINPIQQLRADLKYRQHHTLQHSHPHIEF--NSMKVLEEVDF 165
Query: 165 AINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALG---NSETEKAFRAISSKVPV 221
K++ + ++E L E++ N+LS S KI +L N +E S + P
Sbjct: 166 V----KKQLKTVFERLRLEQQRIENDLSDWSIKILDHSLEEKTNPLSELPIELESLECPY 221
Query: 222 DKVTPSTLPE----------EVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKG---- 267
+ S L E ++ DF L+ R + DH + + +++ G
Sbjct: 222 PDLKSSILSEFYKFTQKYQKKLQDFNLQLEDIY-RNCQLSEEDHWIYQAILDQYPGDLFG 280
Query: 268 -KPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIW-KTKKQQKREEIFKL 325
+ +++ + + P K++ ++ +HEK+ ++ E++ I W K +K ++ + L
Sbjct: 281 RRTLYLDMLQRYFPHKSRHDLVEHEKYCDQYRFAIEQQNILISNWNKNRKDFIQKAVLTL 340
Query: 326 KEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKS----IEMSMKCASQLKEEE 381
E + + ++K+++E K V W+ + +EM + + KEEE
Sbjct: 341 TEACATHEM--ESMLAKDKKKQQELCADLKAKVRQWRAHQEEVARLEMEISARRREKEEE 398
Query: 382 EKEKKHQKERQRQFKLKLLLESYTQQKK------EQEEFLRLE---KEIREKAEKAEKRK 432
+++ +KE ++ + K ++ Y +KK E + RLE K I E++ K +R
Sbjct: 399 KEKLWKKKELLQRAEKKKKIKKYWAKKKQKWQEMEMRDLQRLEELKKLIAEQSLKDRERV 458
Query: 433 NAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRDPSRLYKPT 492
E+ + R + K E+ + ++A ED+ ++ RRL L+++V DP R+ T
Sbjct: 459 KYRQEL--LERRLMEKKEVAL--QEAHEDK--ERARRLEALRKQVAVVAQFDPVRMMSDT 512
Query: 493 KGWEER 498
+ R
Sbjct: 513 MASKAR 518
Score = 32.7 bits (73), Expect = 0.84
Identities = 32/167 (19%), Positives = 70/167 (41%), Gaps = 25/167 (14%)
Query: 282 KTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEI------------------- 322
+ + E ++ + W +K L KK+ I+ + KK+QK +E+
Sbjct: 392 RREKEEEKEKLWKKKELLQRAEKKKKIKKYWAKKKQKWQEMEMRDLQRLEELKKLIAEQS 451
Query: 323 FKLKEKADNTPVLFHNKQEDNQK---QKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKE 379
K +E+ L + + ++ Q+ + K++ +EA +KQ ++ + +
Sbjct: 452 LKDRERVKYRQELLERRLMEKKEVALQEAHEDKERARRLEALRKQVAVVAQFDPVRMMSD 511
Query: 380 EEEKEKKHQKERQRQFKLK---LLLESYTQQKKEQEEFLRLEKEIRE 423
+ + E + +F L+ L +Y +Q+ + LR E +RE
Sbjct: 512 TMASKARMGIEIEEEFILQKPLFTLNTYNEQQIISDPRLRFELALRE 558
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 67.8 bits (164), Expect = 2e-11
Identities = 97/460 (21%), Positives = 178/460 (38%), Gaps = 62/460 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKN---QVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIH 115
K + ++ + ++ EK +N +++ M D S + R++ +EEL+ KL
Sbjct: 862 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL-- 919
Query: 116 SRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFK---EE 172
++ E A Q+ + VK Q Q + K + ++L + ++E + T +E
Sbjct: 920 TKANENASFLQKSIE-DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 978
Query: 173 QRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEE 232
+ YE E KT + E I + + L + K R +S +
Sbjct: 979 LKARYERATSETKTKHEE---ILQNLQKTLLDTEDKLKGAREENSGL------------- 1022
Query: 233 VLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEK 292
+ + E+ +Q + A D ++ K K + E + K Q+E+ ++
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
Query: 293 WYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRK 352
K + + KE + + K ++ R+EI LK+ A QE+N K EE +
Sbjct: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1142
Query: 353 KQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQE 412
+ K ++ + ++K+ E K K E + + + + S +K+ E
Sbjct: 1143 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1202
Query: 413 -EFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKI------------------ 453
E LR E + + K + + + E D KLELK+
Sbjct: 1203 LEKLRNEVTVLRGENASAK---SLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1259
Query: 454 --LDRQAKEDEKSQK-------------QRRLAKLKEKVE 478
D QA EDE++Q+ QR+ LK KVE
Sbjct: 1260 GNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1299
Score = 66.2 bits (160), Expect = 7e-11
Identities = 110/494 (22%), Positives = 214/494 (43%), Gaps = 75/494 (15%)
Query: 54 HLQNWKQKVNQTKKAEFVRTAEKFKNQVIN-MEKDKHSHFYNQKSDFRIEHSMLE--ELE 110
H+ + K++Q + V A++ K +++N +E++K + FR+E + +LE
Sbjct: 402 HVLELEAKMDQLRT--MVEAADREKVELLNQLEEEKRKV---EDLQFRVEEESITKGDLE 456
Query: 111 NKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPD------FVEKLREMMEEIE- 163
+ S K+ ++++ LA V +L+ +L+ KP D ++++ + E++E
Sbjct: 457 VATV-SEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 515
Query: 164 ------NAINTFKE-----------EQRLIY---EELIKEEKTTNNELSAISRK-IDTWA 202
I + KE E + +Y E+L KE ++ ++L +++ D A
Sbjct: 516 TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIA 575
Query: 203 LGNSETEKAFRAISSKVPVDKVTPST---------------LPEEVLDFEKFLQQTGGRQ 247
L S+ E A + + KV+ S + + LD++ ++ +Q
Sbjct: 576 LWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQ 635
Query: 248 GAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQH----EKWYQKFLALEER 303
+ + +R K E LE + K QH E K E +
Sbjct: 636 DSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIK 695
Query: 304 KKE-SIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWK 362
KE + K +Q K + F + KA +L + + + + KK + +EA +
Sbjct: 696 VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 755
Query: 363 KQ-KSIEM-----SMKCASQLKEEEEKEKKH---QKERQRQFKLKLLLESYTQQKKEQ-- 411
KQ K +E+ S K +S +E + +E K Q+ ++K LE Q KE+
Sbjct: 756 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA 815
Query: 412 ---EEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQR 468
EE + +++ ++E K +++ + +S DL KL + D +AK EK +++
Sbjct: 816 EASEEAVSVQRSMQETVNKLHQKEEQFNMLSS----DLEKLRENLADMEAKFREKDEREE 871
Query: 469 RLAKLKEKVENNVS 482
+L K KEK+EN+++
Sbjct: 872 QLIKAKEKLENDIA 885
Score = 58.5 bits (140), Expect = 1e-08
Identities = 100/437 (22%), Positives = 179/437 (40%), Gaps = 84/437 (19%)
Query: 107 EELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVK---------PTPDF------ 151
E L++KL H+ K I +K+ + Q ++++K T +F
Sbjct: 557 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 616
Query: 152 VEKLR-EMMEEIENAIN-------TFKEEQRLIYEELIKEEKTTNNELSAISRKIDT--- 200
+EK+R + EIEN N +E + +L+K K N L AI K+D
Sbjct: 617 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 676
Query: 201 -WALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFV 259
+ +T + KV +V + E+ + F Q + D D
Sbjct: 677 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 736
Query: 260 KVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKR 319
K + K K + +++ EK K L +E+ + S T++ Q R
Sbjct: 737 SSEGKSEMK-------------KLRQQLEAAEKQI-KHLEIEKNAESSKASSITRELQGR 782
Query: 320 EEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMK-CASQLK 378
E KL +N L Q +KE Q K+K A EA ++ S++ SM+ ++L
Sbjct: 783 E--LKLTNLQEN---LSEVSQVKETLEKELQILKEKFA-EASEEAVSVQRSMQETVNKLH 836
Query: 379 EEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL-----RLEKEIRE----KAEKAE 429
++EE+ + ++ + +E+ ++K E+EE L +LE +I E + +
Sbjct: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 896
Query: 430 KRKNAADEISRFQERDLHKLELKIL--------------DRQAK------------EDEK 463
+ DE+ R +ERD+ +L+LK+ D K E+EK
Sbjct: 897 QLTKMNDEL-RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK 955
Query: 464 SQKQRRLAKLKEKVENN 480
+ +R+L+ L++K+E +
Sbjct: 956 KELERKLSDLEKKMETS 972
Score = 50.8 bits (120), Expect = 3e-06
Identities = 96/512 (18%), Positives = 192/512 (37%), Gaps = 97/512 (18%)
Query: 54 HLQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLE-ELENK 112
HL + +N+ ++AE + N + +F +Q E +L+ + K
Sbjct: 678 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK--ATEEKLLDLDALRK 735
Query: 113 LIHSRKTERAKIQQQLAKIHNNVKKLQHQ-----------LKDVKPTPDFVEKLREMMEE 161
K+E K++QQL +K L+ + ++++ + L+E + E
Sbjct: 736 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 795
Query: 162 IENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPV 221
+ T ++E +++ E+ + + E ++ R + + E+ F +SS
Sbjct: 796 VSQVKETLEKELQILKEKFAE----ASEEAVSVQRSMQETVNKLHQKEEQFNMLSS---- 847
Query: 222 DKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPG 281
D EK + + + + D + ++ K K +E + +
Sbjct: 848 -------------DLEKLRENLADMEAKFREKDEREEQLIKAKEK-----LENDIAEIMK 889
Query: 282 KTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQE 341
+ D Q K + L L+ER E +Q+ TK + F K D T ++QE
Sbjct: 890 MSGDNSSQLTKMNDE-LRLKERDVEELQLKLTKANENAS--FLQKSIEDMTVKAEQSQQE 946
Query: 342 DNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLL 401
+K +EE+++ ++ + KK ++ + E E K + E Q K LL
Sbjct: 947 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1006
Query: 402 ESYTQQKKEQEE---FLRLEKEIREKAEKAEKRKNAAD---------------------- 436
++ + K +EE L+ +E+R++A+KA+ + A D
Sbjct: 1007 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1066
Query: 437 ---------EISRFQERDLHKLE-------LKILDRQAKED-------------EKSQKQ 467
E+ +E +L +E L ++ Q E+ +KSQ+
Sbjct: 1067 KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL 1126
Query: 468 RRLAKLKEKVENNVSRDPSRLYKPTKGWEERT 499
L + K+ + R + K EER+
Sbjct: 1127 SALQEENVKLAEELGRSRDEVTSHQKLEEERS 1158
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 67.8 bits (164), Expect = 2e-11
Identities = 97/460 (21%), Positives = 178/460 (38%), Gaps = 62/460 (13%)
Query: 59 KQKVNQTKKAEFVRTAEKFKN---QVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIH 115
K + ++ + ++ EK +N +++ M D S + R++ +EEL+ KL
Sbjct: 897 KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL-- 954
Query: 116 SRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFK---EE 172
++ E A Q+ + VK Q Q + K + ++L + ++E + T +E
Sbjct: 955 TKANENASFLQKSIE-DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 1013
Query: 173 QRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEE 232
+ YE E KT + E I + + L + K R +S +
Sbjct: 1014 LKARYERATSETKTKHEE---ILQNLQKTLLDTEDKLKGAREENSGL------------- 1057
Query: 233 VLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEK 292
+ + E+ +Q + A D ++ K K + E + K Q+E+ ++
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1117
Query: 293 WYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRK 352
K + + KE + + K ++ R+EI LK+ A QE+N K EE +
Sbjct: 1118 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 353 KQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQE 412
+ K ++ + ++K+ E K K E + + + + S +K+ E
Sbjct: 1178 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
Query: 413 -EFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKI------------------ 453
E LR E + + K + + + E D KLELK+
Sbjct: 1238 LEKLRNEVTVLRGENASAK---SLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1294
Query: 454 --LDRQAKEDEKSQK-------------QRRLAKLKEKVE 478
D QA EDE++Q+ QR+ LK KVE
Sbjct: 1295 GNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1334
Score = 65.1 bits (157), Expect = 2e-10
Identities = 107/502 (21%), Positives = 212/502 (42%), Gaps = 89/502 (17%)
Query: 66 KKAEFVRTAEKFKNQVINME---KDKHSHFYNQKSDFRIEHSMLEELENKLIH------- 115
+K E + E+ K +V +++ +++ + ++ ++EH+ ++ELE L+
Sbjct: 423 EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADK 482
Query: 116 -------------SRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPD------FVEKLR 156
S K+ ++++ LA V +L+ +L+ KP D ++++
Sbjct: 483 LQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 542
Query: 157 EMMEEIE-------NAINTFKE-----------EQRLIY---EELIKEEKTTNNELSAIS 195
+ E++E I + KE E + +Y E+L KE ++ ++L +
Sbjct: 543 SLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN 602
Query: 196 RK-IDTWALGNSETEKAFRAISSKVPVDKVTPST---------------LPEEVLDFEKF 239
++ D AL S+ E A + + KV+ S + + LD++
Sbjct: 603 KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 662
Query: 240 LQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQH----EKWYQ 295
++ +Q + + +R K E LE + K QH E
Sbjct: 663 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 722
Query: 296 KFLALEERKKE-SIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQ 354
K E + KE + K +Q K + F + KA +L + + + + KK
Sbjct: 723 KLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKL 782
Query: 355 KLAVEAWKKQ-KSIEM-----SMKCASQLKEEEEKEKKH---QKERQRQFKLKLLLESYT 405
+ +EA +KQ K +E+ S K +S +E + +E K Q+ ++K LE
Sbjct: 783 RQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 842
Query: 406 QQKKEQ-----EEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKE 460
Q KE+ EE + +++ ++E K +++ + +S DL KL + D +AK
Sbjct: 843 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSS----DLEKLRENLADMEAKF 898
Query: 461 DEKSQKQRRLAKLKEKVENNVS 482
EK +++ +L K KEK+EN+++
Sbjct: 899 REKDEREEQLIKAKEKLENDIA 920
Score = 58.5 bits (140), Expect = 1e-08
Identities = 100/437 (22%), Positives = 179/437 (40%), Gaps = 84/437 (19%)
Query: 107 EELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVK---------PTPDF------ 151
E L++KL H+ K I +K+ + Q ++++K T +F
Sbjct: 592 ESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 651
Query: 152 VEKLR-EMMEEIENAIN-------TFKEEQRLIYEELIKEEKTTNNELSAISRKIDT--- 200
+EK+R + EIEN N +E + +L+K K N L AI K+D
Sbjct: 652 IEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 711
Query: 201 -WALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFV 259
+ +T + KV +V + E+ + F Q + D D
Sbjct: 712 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 771
Query: 260 KVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKR 319
K + K K + +++ EK K L +E+ + S T++ Q R
Sbjct: 772 SSEGKSEMK-------------KLRQQLEAAEKQI-KHLEIEKNAESSKASSITRELQGR 817
Query: 320 EEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMK-CASQLK 378
E KL +N L Q +KE Q K+K A EA ++ S++ SM+ ++L
Sbjct: 818 E--LKLTNLQEN---LSEVSQVKETLEKELQILKEKFA-EASEEAVSVQRSMQETVNKLH 871
Query: 379 EEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFL-----RLEKEIRE----KAEKAE 429
++EE+ + ++ + +E+ ++K E+EE L +LE +I E + +
Sbjct: 872 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 931
Query: 430 KRKNAADEISRFQERDLHKLELKIL--------------DRQAK------------EDEK 463
+ DE+ R +ERD+ +L+LK+ D K E+EK
Sbjct: 932 QLTKMNDEL-RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEK 990
Query: 464 SQKQRRLAKLKEKVENN 480
+ +R+L+ L++K+E +
Sbjct: 991 KELERKLSDLEKKMETS 1007
Score = 57.0 bits (136), Expect = 4e-08
Identities = 96/442 (21%), Positives = 180/442 (40%), Gaps = 87/442 (19%)
Query: 113 LIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREM----MEEIENAINT 168
++ + E+ ++ QL + V+ LQ ++++ T +E ++ ++E+E ++
Sbjct: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLF 475
Query: 169 FKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPS- 227
K + + EL T +E S I AL E + R + S P V S
Sbjct: 476 EKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL 535
Query: 228 TLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKG--KPTFMEEVLEHLPGKTQD 285
+L +E+ ++ L+ T DHQ + +H G + T +E+ + L T+
Sbjct: 536 SLLQEISSLQEKLEVTRT--------DHQREITSLKEHFGAREETHQKEI-KALYTATEK 586
Query: 286 EVQQHEKWYQKFLALEERKKESIQIWKTK-------KQQKREEI---------------F 323
+++E K + + I +WK+K QQ EE+
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 646
Query: 324 KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWK---------KQKSIEMSMKCA 374
+LK + + + + ++ E+ Q Q++ +R +EA + K+ S+E
Sbjct: 647 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 706
Query: 375 SQLKEEE--EKEKKHQKERQRQFKLKLL-------------LESYTQQKKEQEE-FLRLE 418
+ +++ E E K ++ + K+K L ++++T Q K EE L L+
Sbjct: 707 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 766
Query: 419 -------------KEIREKAEKAEKR-------KNAADEISRFQERDLHKLELKILDRQA 458
K++R++ E AEK+ KNA + R+L ELK+ + Q
Sbjct: 767 ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQE 826
Query: 459 KEDEKSQKQRRLAK----LKEK 476
E SQ + L K LKEK
Sbjct: 827 NLSEVSQVKETLEKELQILKEK 848
Score = 50.8 bits (120), Expect = 3e-06
Identities = 96/512 (18%), Positives = 192/512 (37%), Gaps = 97/512 (18%)
Query: 54 HLQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLE-ELENK 112
HL + +N+ ++AE + N + +F +Q E +L+ + K
Sbjct: 713 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLK--ATEEKLLDLDALRK 770
Query: 113 LIHSRKTERAKIQQQLAKIHNNVKKLQHQ-----------LKDVKPTPDFVEKLREMMEE 161
K+E K++QQL +K L+ + ++++ + L+E + E
Sbjct: 771 ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSE 830
Query: 162 IENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPV 221
+ T ++E +++ E+ + + E ++ R + + E+ F +SS
Sbjct: 831 VSQVKETLEKELQILKEKFAE----ASEEAVSVQRSMQETVNKLHQKEEQFNMLSS---- 882
Query: 222 DKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPG 281
D EK + + + + D + ++ K K +E + +
Sbjct: 883 -------------DLEKLRENLADMEAKFREKDEREEQLIKAKEK-----LENDIAEIMK 924
Query: 282 KTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQE 341
+ D Q K + L L+ER E +Q+ TK + F K D T ++QE
Sbjct: 925 MSGDNSSQLTKMNDE-LRLKERDVEELQLKLTKANENAS--FLQKSIEDMTVKAEQSQQE 981
Query: 342 DNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKLKLLL 401
+K +EE+++ ++ + KK ++ + E E K + E Q K LL
Sbjct: 982 AAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLL 1041
Query: 402 ESYTQQKKEQEE---FLRLEKEIREKAEKAEKRKNAAD---------------------- 436
++ + K +EE L+ +E+R++A+KA+ + A D
Sbjct: 1042 DTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDT 1101
Query: 437 ---------EISRFQERDLHKLE-------LKILDRQAKED-------------EKSQKQ 467
E+ +E +L +E L ++ Q E+ +KSQ+
Sbjct: 1102 KQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL 1161
Query: 468 RRLAKLKEKVENNVSRDPSRLYKPTKGWEERT 499
L + K+ + R + K EER+
Sbjct: 1162 SALQEENVKLAEELGRSRDEVTSHQKLEEERS 1193
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 67.0 bits (162), Expect = 4e-11
Identities = 84/452 (18%), Positives = 190/452 (42%), Gaps = 34/452 (7%)
Query: 64 QTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTE--- 120
+ K +F + A ++Q+ + ++ QK + LEE +N L ++ E
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEET-RQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358
Query: 121 RAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEEL 180
R +++Q+ + + + + ++ D T + +E+ ++ + + A++ EE+ L Y++L
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 181 IKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEE-------- 232
K + EL ++ +D S EK + + +K + EE
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 233 ------VLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDE 286
L + L++ + ++ + Q + + K + V E K E
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 287 VQ------QHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQ 340
Q Q E+ + A E+ K + K Q ++ E+ + L +
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 341 EDNQKQKEEQRKKQKLAVEAWKKQ----KSIEMSMKCASQLKEEEEKEKKHQKERQRQFK 396
+ + + E++RK++ LAV + KK K +E ++ A++ ++E K+ + + + + ++
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 397 LKLLL------ESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLE 450
+L E + Q K+ +++ LE EI + E+ + A + ++ ++
Sbjct: 1659 RELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT 1718
Query: 451 LKILDRQAKEDEKSQKQRRLAKLKEKVENNVS 482
+ A DEK + + R+A+L+E++E S
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750
Score = 57.4 bits (137), Expect = 3e-08
Identities = 89/442 (20%), Positives = 189/442 (42%), Gaps = 71/442 (16%)
Query: 75 EKFKNQVINMEKDK-HSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHN 133
E+ +NQ++ EK K +H + + E ++L+ E+ + ++ K+
Sbjct: 934 EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQ--------LEKVTAEAKIKKMEE 985
Query: 134 NVKKLQHQ----LKDVKPTPDFV-EKLREMMEEIENAINTFK---EEQRLI--YEELIKE 183
+ L+ Q +K+ K D + E ++ EE E A N K +++ +I EE +K+
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1045
Query: 184 EKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQT 243
E+ T EL RK+D T+ + + +D++ L K ++
Sbjct: 1046 EEKTRQELEKAKRKLD-----GETTDLQDQIAELQAQIDELK--------LQLAKKEEEL 1092
Query: 244 GGRQGAWDD--YDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALE 301
G DD N +KV + + + ++E E +Q ++ AL+
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK 1152
Query: 302 ERKKESI------QIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQK 355
++++ Q +TK++Q+ E+ K E+ + ++++ Q ++ R++
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEE----------ETKNHEAQIQDMRQRHA 1202
Query: 356 LAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKERQRQFKL--KLLLESYTQQKKEQEE 413
A+E +Q +E + + + L++ ++ + KE + K+ ++ ES ++KK +
Sbjct: 1203 TALEELSEQ--LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 414 FLRLEKEIR-------EKAEKAEKRKNAADEISRFQE----------RDLHKLELKILDR 456
L ++ E AEKA K +N D +S E +D LE ++ D
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 457 QAKEDEKSQKQRRLAKLKEKVE 478
Q E+++++ L+ ++E
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLE 1342
Score = 55.1 bits (131), Expect = 2e-07
Identities = 89/443 (20%), Positives = 183/443 (41%), Gaps = 72/443 (16%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLI 114
+Q+ +Q+ + T E E+ K N+EK+K + K + E +L++++ +
Sbjct: 1194 IQDMRQR-HATALEELSEQLEQAKRFKANLEKNKQGLETDNK-ELACEVKVLQQVKAESE 1251
Query: 115 HSRKTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQR 174
H RK A++Q+ AK+ +L+ +L EK ++ E++N +E ++
Sbjct: 1252 HKRKKLDAQVQELHAKVSEG-DRLRVEL---------AEKASKLQNELDNVSTLLEEAEK 1301
Query: 175 LIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVL 234
K K + S S+ DT L ET + +SS++ + ++L E+
Sbjct: 1302 -------KGIKFAKDAASLESQLQDTQELLQEETRQKLN-LSSRIRQLEEEKNSLQEQQE 1353
Query: 235 DFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWY 294
+ E+ R + + ++ L K D++ E
Sbjct: 1354 EEEE----------------------ARKNLEKQVLALQSQLADTKKKVDDDLGTIE--- 1388
Query: 295 QKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQ 354
+LEE KK+ ++ + Q+ E+ +K + T + +D + QR+
Sbjct: 1389 ----SLEEAKKKLLKDAEALSQRLEEKALAY-DKLEKTKNRLQQELDDLTVDLDHQRQ-- 1441
Query: 355 KLAVEAWKKQKSIE--MSMKCASQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKEQE 412
+A KKQK + ++ + + + EE+++ + R+++ K L + + + +E
Sbjct: 1442 -VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 413 EFLRLEKEIREKAE--------------KAEKRKNAADEISRFQERDLHKLELKILDRQA 458
EF R K++R E + EK K A ++ L +LE ++ QA
Sbjct: 1501 EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL---QA 1557
Query: 459 KEDEKSQKQRRLAKLKEKVENNV 481
ED K + + + +K + E ++
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDL 1580
Score = 49.3 bits (116), Expect = 9e-06
Identities = 87/402 (21%), Positives = 167/402 (41%), Gaps = 78/402 (19%)
Query: 87 DKHSHFYNQKSDFRIEHSMLEELENKLIHSRKTERAKIQQQLAKIHNNVKKLQHQLKDVK 146
D+ H N R + + EL+ S K R K ++Q + ++ L+ +L+D
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDF-ESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 147 PTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTTN-NELSAISRKIDTWALGN 205
T ++LR E+ + EE+ +E I++ + + L +S ++
Sbjct: 1160 DTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL------- 1212
Query: 206 SETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKH 265
E K F+A K +K T +E+ K LQQ VK ++H
Sbjct: 1213 -EQAKRFKANLEK---NKQGLETDNKELACEVKVLQQ----------------VKAESEH 1252
Query: 266 KGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKL 325
K K K +VQ+ L + E ++ + + E+ KL
Sbjct: 1253 KRK-------------KLDAQVQE----------LHAKVSEGDRL----RVELAEKASKL 1285
Query: 326 KEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEK 385
+ + DN L +E ++K K A +A S+E ++ +L +EE ++K
Sbjct: 1286 QNELDNVSTLL----------EEAEKKGIKFAKDA----ASLESQLQDTQELLQEETRQK 1331
Query: 386 KHQKERQRQFKLKLLLESYTQQKKEQEEFLR--LEKEIRE-KAEKAEKRKNAADEISRFQ 442
+ R RQ + + ++ Q+++E+EE R LEK++ +++ A+ +K D++ +
Sbjct: 1332 LNLSSRIRQLEEE---KNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE 1388
Query: 443 ERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVENNVSRD 484
+ K +L + D +A +K KL EK +N + ++
Sbjct: 1389 SLEEAKKKL-LKDAEALSQRLEEKALAYDKL-EKTKNRLQQE 1428
Score = 48.9 bits (115), Expect = 1e-05
Identities = 61/248 (24%), Positives = 110/248 (44%), Gaps = 66/248 (26%)
Query: 289 QHEKWYQKFLALEERKKESIQIWKTKK--QQKREEIFKLKEKADNTPVLFHNKQEDNQKQ 346
+H +W++ F + K +Q+ + ++ Q K EE+ K+KEK + +Q+
Sbjct: 830 RHWQWWRVFTKV----KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQL 885
Query: 347 KEEQR---------------KKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQKER 391
EE+ ++ A A KKQ+ E+ S+++EEEE+ + Q E+
Sbjct: 886 LEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 392 QRQ----------------FKLKLLLESYTQQ---KKEQEEFLRLE----KEIREK---- 424
++ + KL LE T + KK +EE L LE K I+EK
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 425 ----------AEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLK 474
AE+ EK KN A + R+ ++ + L+ + K++EK++++ L K K
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLA------KIRNKQEVMISDLEERLKKEEKTRQE--LEKAK 1057
Query: 475 EKVENNVS 482
K++ +
Sbjct: 1058 RKLDGETT 1065
Score = 47.4 bits (111), Expect = 3e-05
Identities = 83/455 (18%), Positives = 190/455 (41%), Gaps = 74/455 (16%)
Query: 55 LQNWKQKVNQTKKAEFVRTAEKFKNQVINMEKDKHSHFYNQKSDFRIEHSMLEELENKLI 114
L+ + ++ T+ A+ +R + E+D + + R+ + ELE +L
Sbjct: 1548 LEELEDELQATEDAK-LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 115 HSRKTERAKIQQQLAKIHNNVKKLQHQLKDV-KPTPDFVEKLREMMEEIENAINTFKEEQ 173
RK +RA K+ ++K L+ Q++ K + +++LR++ ++++
Sbjct: 1607 DERK-QRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD--------- 1656
Query: 174 RLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEV 233
Y+ ++E + + +E+ A S+ E+EK +++ +++ L EE+
Sbjct: 1657 ---YQRELEEARASRDEIFAQSK----------ESEKKLKSLEAEI-------LQLQEEL 1696
Query: 234 LDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEV--LEHLPGKTQDEVQQHE 291
E+ + + D ++ N GK ++E LE + ++E+++ +
Sbjct: 1697 ASSERARRHAEQERDELAD-------EITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 292 KWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQR 351
+ L + +K ++Q+ + E +K+DN +Q+ ++ KE +
Sbjct: 1750 SNME--LLNDRFRKTTLQVDTLNAELAAER--SAAQKSDNA------RQQLERQNKELKA 1799
Query: 352 KKQKLAVEAWKKQKSIEMSMKCA-SQLKEEEEKEKKHQKERQRQFKLKLLLESYTQQKKE 410
K Q+L K K+ +++ QL+E+ E+E K + + +
Sbjct: 1800 KLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR-------------- 1845
Query: 411 QEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQRRL 470
R EK+++E + E + AD+ E+ +K L RQ +E E+ +
Sbjct: 1846 -----RTEKKLKEIFMQVEDERRHADQYKEQMEK--ANARMKQLKRQLEEAEEEATRANA 1898
Query: 471 AKLKEKVE-NNVSRDPSRLYKPTKGWEERTKKIGP 504
++ K + E ++ + L + + R ++ GP
Sbjct: 1899 SRRKLQRELDDATEANEGLSREVSTLKNRLRRGGP 1933
Score = 46.6 bits (109), Expect = 6e-05
Identities = 78/380 (20%), Positives = 170/380 (44%), Gaps = 48/380 (12%)
Query: 128 LAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEELIKEEKTT 187
L ++ ++LQ + +++ + K+ +EE+E EE+ ++ E+L E
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAE---- 899
Query: 188 NNELSAISRKIDT-WALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFEKFLQ----Q 242
EL A + ++ A E E+ + S+V ++ L E + +Q Q
Sbjct: 900 -TELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQ 958
Query: 243 TGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEE 302
+GA Q + + K MEE + L Q+ K+ ++ +E+
Sbjct: 959 LDEEEGA-----RQKLQLEKVTAEAKIKKMEEEILLLE-------DQNSKFIKEKKLMED 1006
Query: 303 RKKE-SIQIWKTKKQQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEE-QRKKQKLAVEA 360
R E S Q+ ++++K + + K++ K + + + +K ++E ++ K+KL E
Sbjct: 1007 RIAECSSQL--AEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 361 WKKQKSI--------EMSMKCASQLKEEEEKE----KKHQKERQRQFKLKLLLESYTQQK 408
Q I E+ ++ A K+EEE + + + + LK++ E Q
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLA---KKEEELQGALARGDDETLHKNNALKVVRELQAQIA 1121
Query: 409 KEQEEFLRLEKEIREKAEKAEKRKNAADEISRFQERDLHKLELKILDRQAKEDEKSQKQR 468
+ QE+F EK R KAEK ++++ ++E+ + +LE + A+++ ++++++
Sbjct: 1122 ELQEDF-ESEKASRNKAEK--QKRDLSEELEALKT----ELEDTLDTTAAQQELRTKREQ 1174
Query: 469 RLAKLKEKVENNVSRDPSRL 488
+A+LK+ +E +++
Sbjct: 1175 EVAELKKALEEETKNHEAQI 1194
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 66.2 bits (160), Expect = 7e-11
Identities = 100/478 (20%), Positives = 199/478 (41%), Gaps = 72/478 (15%)
Query: 64 QTKKAEFVRTAEKFKNQVINMEKD----KHSHFYNQKSDFRIEHSMLEELENK--LIHSR 117
+ K+EF + +K K ++++EK KH ++ + + + + LE + H
Sbjct: 870 KNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQL 929
Query: 118 KTERAKIQQQLAKIHNNVKK-------LQHQLKDVKPTPDFVEKLREMME-EIENAINTF 169
K E +Q+QL + N +K+ LQ + ++K + + +K E ++ E++ A+
Sbjct: 930 KLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQK 989
Query: 170 KEEQRLIYEELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTL 229
E + + ++L + + EL+A KI ++++ F+ + S +
Sbjct: 990 TELENKLQQQLTQAAQ----ELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 230 PEEVLDFEKFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQ 289
+++ E+ L D ++N + +NK + + LE K + ++Q+
Sbjct: 1046 RQDLKSVEEKLSLAQE-----DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQE 1100
Query: 290 HEKWYQ------------------KFLALEERK----KESIQIWKTKKQQKREEIFKLKE 327
K Q K +EE K KE ++ + K K E I ++
Sbjct: 1101 RCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160
Query: 328 KADNTPVLFHNKQE-----DNQKQKEEQRKK-QKLAVEAWKKQKS------IEMSMKCAS 375
D +L K E D+ K EQ K+ Q++ + KK++ IE K S
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHS 1220
Query: 376 QLKEEEEKEKKHQK-ERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKR--- 431
++KE+E KKH++ E + ++ L E+ KKE + R E+ ++ +
Sbjct: 1221 EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAV 1280
Query: 432 -----KNAADEISRFQER------DLHKLELKILDRQAKEDEKSQKQRRLAKLKEKVE 478
+N DE ER ++ KL+ K+L+ Q K D + + L + + ++
Sbjct: 1281 LEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 63.2 bits (152), Expect = 6e-10
Identities = 103/480 (21%), Positives = 202/480 (42%), Gaps = 73/480 (15%)
Query: 57 NWKQKVNQTKKAEFVRTAEKFKNQVIN---MEKDKHSHFYNQKSDFRIEH-------SML 106
N Q+ N T + + + EK KNQ + +++ H QK+ R + +
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 107 EELENKLIHSR------------KTE------------RAKIQQQLAKIHNNVKKLQHQL 142
EL ++L S+ KTE RA +Q L N ++ Q +L
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
Query: 143 KDVKPTPDFVE-KLREMME---EIENAINTFKEEQRLIYEELIKEEKTTNNELSAISRKI 198
+ D V KL++ E ++E+ + +KE+ L E+KT EL +K+
Sbjct: 684 NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKY------LSLEQKT--EELEGQIKKL 735
Query: 199 DTWALG-NSETEKAFRAISSK--VPVDKVTPSTLPEEVLDFEKFLQQTGGRQGAWDDYDH 255
+ +L + E+A + + + + D +T + L+ EK + + D
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSS-------TRLDL 788
Query: 256 QNFVKVRNKHKGKPTFMEEVLEHLPGKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKK 315
Q + K K T EE + L + Q+ + +++ + +Q K +K
Sbjct: 789 QKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEK 848
Query: 316 QQKREEIFKLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCAS 375
+ E+ +K+K N + + +K+ ++ K L +E K+ ++ ++ +
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG-KAAILDLEKTCKELKHQLQVQMEN 907
Query: 376 QLKEEEEKEKKHQKERQRQFKLKLLLESYTQQ--------KKEQEEFLRLEKEIREKAEK 427
LKE++E +K +KE++ +LKL L S +Q K+ ++E +L+ I E +
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQS 967
Query: 428 AEKRKNAADEI-SRFQERDLHKLELKILDRQAKEDEKSQKQRRLAKLKEKV---ENNVSR 483
+E++K + + + L K EL+ + + +Q + LA KEK+ +NN +
Sbjct: 968 SEQKKKQIEALQGELKIAVLQKTELE----NKLQQQLTQAAQELAAEKEKISVLQNNYEK 1023
Score = 62.4 bits (150), Expect = 1e-09
Identities = 103/474 (21%), Positives = 190/474 (40%), Gaps = 64/474 (13%)
Query: 75 EKFKNQVINMEKDKHSHFYNQ--KSDFRIEHSM--LEELENKLIHSRKTERAKIQQQLAK 130
EK+ ++ + E +K+ Q K D + S L+ LE +L +TE I+Q
Sbjct: 102 EKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL-EEAQTENFNIKQMKDL 160
Query: 131 IHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIYEEL---------I 181
+L ++ D+K D LRE E+ + ++ + ++L I
Sbjct: 161 FEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGI 220
Query: 182 KEEKTTNNELSAISRKIDTWALGNS-ETEK---AFRAISSKVPVDKVTPSTL-------P 230
++ EL + +D L E+EK + + S+ + T S L P
Sbjct: 221 EDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 231 EEVLDFEKFLQQ--------TGGRQGAWDDY--DHQNFVKVRNKHKGKPTFMEEVLEHLP 280
+EV + + LQ+ T Q ++ Q++ K+ KH + + + L
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLH 340
Query: 281 GKTQDEVQQHEKWYQKFLALEERKKESIQIWKTKKQQKREEIFKLKEKADNTPVLF-HNK 339
K D Q Q L+ E I + + +K E KLKE+ + H K
Sbjct: 341 QKDLDCQQ-----LQSRLSASETSLHRIHV---ELSEKGEATQKLKEELSEVETKYQHLK 392
Query: 340 QEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKEEEEKEKKHQK-ERQRQFKLK 398
E Q Q++ + K+Q Q E++ + L+ E + + H + + QRQ +
Sbjct: 393 AEFKQLQQQREEKEQH------GLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSE 446
Query: 399 LLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEI-SRFQERDLHKLELKILDRQ 457
L++ Q Q + RLE++++EK + + ++ D+ + QE+ + R+
Sbjct: 447 KLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLRE 506
Query: 458 AKED---------EKSQKQRRLAKLKEKVENNVS---RDPSRLYKPTKGWEERT 499
A+ D +K QK + L L +K + N+S ++ LY + E T
Sbjct: 507 AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGET 560
Score = 53.5 bits (127), Expect = 5e-07
Identities = 83/390 (21%), Positives = 154/390 (39%), Gaps = 88/390 (22%)
Query: 118 KTERAKIQQQLAKIHNNVKKLQHQLKDVKPTPDFVEKLREMMEEIENAINTFKEEQRLIY 177
K E K+Q Q A + +L+ +L P V + ++++++++N ++ + +
Sbjct: 252 KDECKKLQSQYASSEATISQLRSELAK---GPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 178 EELIKEEKTTNNELSAISRKIDTWALGNSETEKAFRAISSKVPVDKVTPSTLPEEVLDFE 237
E L+K+E+ D L E++ K +TL ++ LD
Sbjct: 309 ENLLKKEQ-------------DYTKLEEKHNEESVSK--------KNIQATLHQKDLD-- 345
Query: 238 KFLQQTGGRQGAWDDYDHQNFVKVRNKHKGKPTFMEEVLE------HLPGKTQDEVQQHE 291
QQ R A + H+ V++ K + EE+ E HL + + QQ E
Sbjct: 346 --CQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQRE 403
Query: 292 KWYQKFLALEE---------------------RKKESIQIWKTKKQQKREEIF------- 323
+ Q L L+ R KE Q+ K K +++
Sbjct: 404 EKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLS 463
Query: 324 ----KLKEKADNTPVLFHNKQEDNQKQKEEQRKKQKLAVEAWKKQKSIEMSMKCASQLKE 379
+LKEK N+ L H + Q+ +E+Q +Q + + Q +E L++
Sbjct: 464 RLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLE------QVLRQ 517
Query: 380 EEEKEKKHQKERQRQFKLKLLLESYTQQKKEQEEFLRLEKEIREKAEKAEKRKNAADEIS 439
+K++K Q L+ LL+ K +E LEKE + K + + ++
Sbjct: 518 IGDKDQKIQ-------NLEALLQ------KSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 440 RFQERDLHKLELKI--LDRQAKEDEKSQKQ 467
+ QE++ H L+ ++ L + K +S KQ
Sbjct: 565 QLQEKN-HTLQEQVTQLTEKLKNQSESHKQ 593
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.351
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,450,102
Number of Sequences: 37866
Number of extensions: 1046630
Number of successful extensions: 24495
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 574
Number of HSP's successfully gapped in prelim test: 1177
Number of HSP's that attempted gapping in prelim test: 7652
Number of HSP's gapped (non-prelim): 7116
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.