Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 94536811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo
sapiens]
(1606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 3245 0.0
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 1675 0.0
gi|114520609 neural precursor cell expressed, developmentally do... 447 e-125
gi|114520607 neural precursor cell expressed, developmentally do... 447 e-125
gi|222352183 neural precursor cell expressed, developmentally do... 378 e-104
gi|21361472 neural precursor cell expressed, developmentally dow... 378 e-104
gi|222352094 neural precursor cell expressed, developmentally do... 378 e-104
gi|222352092 neural precursor cell expressed, developmentally do... 378 e-104
gi|222352090 neural precursor cell expressed, developmentally do... 378 e-104
gi|222352088 neural precursor cell expressed, developmentally do... 378 e-104
gi|222352086 neural precursor cell expressed, developmentally do... 378 e-104
gi|222352084 neural precursor cell expressed, developmentally do... 378 e-104
gi|222352082 neural precursor cell expressed, developmentally do... 378 e-104
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 378 e-104
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 375 e-103
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 365 e-100
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 360 5e-99
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 360 5e-99
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 360 8e-99
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 359 1e-98
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 305 2e-82
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 270 8e-72
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 185 3e-46
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 185 3e-46
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 185 3e-46
gi|87116668 hypothetical protein LOC9870 [Homo sapiens] 184 5e-46
gi|190341084 HECT domain containing 2 isoform a [Homo sapiens] 179 2e-44
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 176 1e-43
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 176 1e-43
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 176 1e-43
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 3245 bits (8414), Expect = 0.0
Identities = 1606/1606 (100%), Positives = 1606/1606 (100%)
Query: 1 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 60
MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG
Sbjct: 1 MLLHLCSVKNLYQNRFLGLAAMASPSRNSQSRRRCKEPLRYSYNPDQFHNMDLRGGPHDG 60
Query: 61 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 120
VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV
Sbjct: 61 VTIPRSTSDTDLVTSDSRSTLMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEV 120
Query: 121 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 180
LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK
Sbjct: 121 LSENFLDYKNRGVNGSHRGQIIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVK 180
Query: 181 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 240
NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI
Sbjct: 181 NSAAPIFKSIGADETVQGQGSRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSI 240
Query: 241 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 300
FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK
Sbjct: 241 FPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGK 300
Query: 301 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE 360
LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE
Sbjct: 301 LSMPVQRLLERHAIGDRVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPE 360
Query: 361 SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA 420
SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA
Sbjct: 361 SAQIQDSPMNNLMESGSGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAA 420
Query: 421 VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA 480
VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA
Sbjct: 421 VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGEEASALLLEDGEAPA 480
Query: 481 STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS 540
STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS
Sbjct: 481 STKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEGRLQLRASVKRKSRPCSLPVS 540
Query: 541 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL 600
ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL
Sbjct: 541 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKDSSEKDGL 600
Query: 601 SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS 660
SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS
Sbjct: 601 SEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPSTGSESDS 660
Query: 661 SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS 720
SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS
Sbjct: 661 SPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFS 720
Query: 721 SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV 780
SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV
Sbjct: 721 SVDSAKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHV 780
Query: 781 ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID 840
ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID
Sbjct: 781 ERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARID 840
Query: 841 SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED 900
SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED
Sbjct: 841 SHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEED 900
Query: 901 SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN 960
SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN
Sbjct: 901 SGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQSPAVKFITN 960
Query: 961 PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL 1020
PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL
Sbjct: 961 PEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLEL 1020
Query: 1021 PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS 1080
PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS
Sbjct: 1021 PRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEAS 1080
Query: 1081 EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA 1140
EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA
Sbjct: 1081 EVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLA 1140
Query: 1141 RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC 1200
RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC
Sbjct: 1141 RNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRC 1200
Query: 1201 SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL 1260
SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL
Sbjct: 1201 SPCSSPQNSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLL 1260
Query: 1261 EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN 1320
EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN
Sbjct: 1261 EGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSAN 1320
Query: 1321 DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL 1380
DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL
Sbjct: 1321 DTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDL 1380
Query: 1381 EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI 1440
EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI
Sbjct: 1381 EYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYI 1440
Query: 1441 ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE 1500
ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE
Sbjct: 1441 ERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTE 1500
Query: 1501 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1560
YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE
Sbjct: 1501 YRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIE 1560
Query: 1561 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE
Sbjct: 1561 KWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 1675 bits (4339), Expect = 0.0
Identities = 928/1659 (55%), Positives = 1103/1659 (66%), Gaps = 161/1659 (9%)
Query: 22 MASPSRNSQSRRRCKEP-LRYSYNPDQFHNMDLRGGPHDGVTIPRSTSDTDLVTSDSRST 80
MAS +R R + P +RY+ +P+ ++ + + +T+ R+ SDTDLVTS+SRS+
Sbjct: 1 MASSAREHLLFVRRRNPQMRYTLSPENLQSLAAQSSMPENMTLQRANSDTDLVTSESRSS 60
Query: 81 LMVSSSYYSIGHSQDLVIHWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHRGQ 140
L S Y++G +Q+L+I WDIKEEVD DWIG+Y IDE NF D KNRGV G+ +GQ
Sbjct: 61 LTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQ 120
Query: 141 IIWKIDASSYFVEPETKICFKYYHGVSGALRATTPSVTVKNSAAPIFKSIGADETVQGQG 200
I+W+I+ YF+EPE KICFKYYHG+SGALRATTP +TVKN A +GA+ G
Sbjct: 121 IVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITVKNPAV----MMGAEGMEGGAS 176
Query: 201 ----SRRLISFSLSDFQAMGLKKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKII 256
SR+L+SF+LSD +A+GLKKGMFFNPDPYLK+SIQPGK S FP HHGQERRS II
Sbjct: 177 GNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQPGKKSSFPTCAHHGQERRSTII 236
Query: 257 GNTVNPIWQAEQFSFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGD 316
NT NPIW E++SF +L TDVLEIE+KDKFAKSRPIIKRFLGKL++PVQRLLER AIGD
Sbjct: 237 SNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKRFLGKLTIPVQRLLERQAIGD 296
Query: 317 RVVSYTLGRRLPTDHVSGQLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESG 376
+++SY LGRRLP DHVSG LQF+ E+TSS+H D ++ T +S +L
Sbjct: 297 QMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEDASPEAVGT----ILGVNSVNGDLGSPS 352
Query: 377 SGEPRSEAPESSESWKPEQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPE 436
E + S+ + E S DG S S E + TE
Sbjct: 353 DDEDMPGSHHDSQVCSNGPVSEDSAADGTPKHSFRTSSTLE---IDTE------------ 397
Query: 437 GAGELLAQVQKDIQPAPSAEELAEQLDLGEE--------ASALLLEDGEAPASTKEEPLE 488
EL + + P + L + LD E A+ G +P P +
Sbjct: 398 ---ELTSTSSRTSPPRGRQDSLNDYLDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTD 454
Query: 489 EEATTQSRAGREEEEKE-QEEEGDVSTLEQGEGRLQLR-------ASVKRKSRPCSLPVS 540
+EE+ E Q++ G S+LE+ G + S+ +++ PV
Sbjct: 455 TRLNAMLHIDSDEEDHEFQQDLGYPSSLEEEGGLIMFSRASRADDGSLTSQTKLEDNPVE 514
Query: 541 ELETVIASACGDPETPRTHYIRIHTLLHSMPSAQGGSAAEEEDGAEEESTLKD--SSEKD 598
E A + P + L S S G A EE +G E D S+E
Sbjct: 515 NEEASTHEAASFEDKPEN----LPELAES--SLPAGPAPEEGEGGPEPQPSADQGSAELC 568
Query: 599 GLSEVDTVAADPSALEEDREEPEGATPGTAHPGHSGGHFPSLANGAAQDGDTHPS----- 653
G EVD + GA GT+ SGG +++ + D + PS
Sbjct: 569 GSQEVD-------------QPTSGADTGTSDA--SGGSRRAVSETESLDQGSEPSQVSSE 613
Query: 654 --------TGSESDSSPRQGGDHSCEGCDASCCSPSCYSSSCYSTSCYSSSCYSASCYSP 705
T S S++S R G+ E D+SC S T C
Sbjct: 614 TEPSDPARTESVSEASTRPEGESDLECADSSCNESVTTQLSSVDTRC------------- 660
Query: 706 SCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEENSAF-----------ESVPDSMQ 754
SS++SA+ E+ FSSQ++E+ +A ESV +
Sbjct: 661 --------------SSLESARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGS 706
Query: 755 SPELDPESTNGAGPWQDELAAPS-----------GHVERSPEGLESPVA--GPSNRREGE 801
P + S GP + P G +E + ESP G + +G
Sbjct: 707 LPVVQVPSGEDEGPGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQGT 766
Query: 802 CP-------------ILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYV 848
C + QP+ LPS+R + Y +DE LPPNWEARIDSHGR+FYV
Sbjct: 767 CEGATAQEEGATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYV 826
Query: 849 DHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQ 908
DHVNRTTTWQRPTA P ++RS SIQQMEQLNRRYQ+I+RT+ ER EE++ +
Sbjct: 827 DHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEENTNAID--- 883
Query: 909 APAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQ-KITLLLQSPAVKFITNPEFFTVL 967
G+ EA+ Q+S D RRE L S+ +ITLLLQSP VKF+ +PEFFTVL
Sbjct: 884 ---------GAGEEADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVL 934
Query: 968 HANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIK 1027
H+N SAYR+FT++TCLKHMI KVRRD +FERYQHNRDLV F+NMFA+ +LELPRGWE+K
Sbjct: 935 HSNPSAYRMFTNNTCLKHMITKVRRDTHHFERYQHNRDLVGFLNMFANKQLELPRGWEMK 994
Query: 1028 TDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRG 1087
D QGK+FFVDHNSR TTFIDPR+PLQ+ R + L HRQHL R RS+SAGE E SR+ G
Sbjct: 995 HDHQGKAFFVDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEVGEDSRHAG 1054
Query: 1088 ASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLRE 1147
+L RP + R Q+Q + +P+AYNDKIVAFLRQPNIFE+LQERQP L RNH+LRE
Sbjct: 1055 PPVLPRPSSTFNTVSRPQYQ-DMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLRE 1113
Query: 1148 KIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYSFSPRCSPCSSPQ 1207
KI +IRTEG GL +LS DADLV+LLSLFEEEIMSYVP A HP Y SPR SP SSPQ
Sbjct: 1114 KIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPVSSPQ 1173
Query: 1208 NSPGLQRASARAPSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQV 1267
NSPG QRA+ARAP+PY+RDFEAKLRNFYRKLE KG+GQGPGK+KLIIRRDHLLE FNQ+
Sbjct: 1174 NSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQI 1233
Query: 1268 MAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQI 1327
M YSRK+LQRNKLYVTFVGEEGLDYSGPSREFFFL+S+ELFNPYYGLFEYSANDTYTVQI
Sbjct: 1234 MGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQI 1293
Query: 1328 SPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
SPMSAFV+NH EWFRFSGRILGLALIHQYLLDAFFTRPFYKALLR+ CDLSDLEYLDEEF
Sbjct: 1294 SPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEF 1353
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
HQSLQWMKDN+I DILDLTFTVNEEVFGQ+TERELK GGAN VTEKNKKEYIERMVKWR
Sbjct: 1354 HQSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWR 1413
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
+ERGVVQQTE+LVRGFYEVVD+RLVSVFDARELELVIAGTAEIDL+DWRNNTEYRGGYHD
Sbjct: 1414 IERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHD 1473
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H+VIRWFWAAVERFNNEQRLRLLQFVTGTSS+PYEGFA+LRGSNG RRFC+EKWGKIT+
Sbjct: 1474 NHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRGSNGPRRFCVEKWGKITA 1533
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
LPRAHTCFNRLDLPPYPS+SMLYEKLLTAVEETSTFGLE
Sbjct: 1534 LPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1572
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 447 bits (1149), Expect = e-125
Identities = 277/777 (35%), Positives = 407/777 (52%), Gaps = 75/777 (9%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQ 889
PLPP WE R D GR +YV+H +R T W+RPT +G+IQ Q R +
Sbjct: 192 PLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAE-NGNIQLQAQ---RAFTTR 247
Query: 890 RTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLL 949
R I+ E D+ S + ++ RE + ++Q
Sbjct: 248 RQISEETESVDN----------------------RESSENWEIIREDEATMYSNQAF--- 282
Query: 950 LQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNF 1009
P+ +N + T L +A ++ + +R + +
Sbjct: 283 ---PSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPT 339
Query: 1010 INMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQ 1069
+ + T LP GWE K D++G+S++VDHNSR TT+ P + Q + LT Q
Sbjct: 340 LPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--QATVETSQLTSSQS-- 395
Query: 1070 RLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIF 1129
SAG S+ S + + +P S+ + LP + + PN
Sbjct: 396 -----SAGPQSQASTSDSGQQVTQP---------SEIEQGFLPKGWEVR-----HAPNGR 436
Query: 1130 EMLQERQPSLARNHTLREKIH-YIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQA 1188
+ R KI ++R G L DL L +EE +
Sbjct: 437 PFFIDHNTKTTTWEDPRLKIPAHLR-----GKTSLDTSNDLGPLPPGWEERTHT------ 485
Query: 1189 AFHPGYSFSPRCSPCSSPQNSPGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGP 1247
G F + + P L+ + P+ PY RD++ K F RKL+ + P
Sbjct: 486 ---DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN--DIP 540
Query: 1248 GKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
K ++ +RR +LE ++ ++M R + + +L++ F GE+GLDY G +RE+FFL+S+E+
Sbjct: 541 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM 600
Query: 1308 FNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPF 1366
FNPYYGLFEYSA D YT+QI+P S E+HL +F+F GR+ G+A+ H LLD FF RPF
Sbjct: 601 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 660
Query: 1367 YKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGG 1426
YK +L P L D+E +D E++ SL+W+ +N+ T+ LDL F ++EE+FGQ + ELK+GG
Sbjct: 661 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGG 719
Query: 1427 ANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAG 1486
+ VT KNKKEYI +++WR + +Q A GF+E++ L+ +FD ELEL++ G
Sbjct: 720 SEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG 779
Query: 1487 TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFA 1546
++D+NDWR +T+Y+ GY H VI+WFW AV ++E+R+RLLQFVTGTS VP GFA
Sbjct: 780 LGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFA 839
Query: 1547 ALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
L GSNG + F +E+WG LPRAHTCFNRLDLPPY S+ L++KL A+E T F
Sbjct: 840 ELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 896
Score = 65.1 bits (157), Expect = 5e-10
Identities = 83/339 (24%), Positives = 118/339 (34%), Gaps = 96/339 (28%)
Query: 721 SVDSAKISESTVFSSQDDEEE-ENSAFESVPDSMQ-------SPELDPESTNGAGPWQDE 772
SVD+ + SE+ +D+ N AF S P S + EL+ T +
Sbjct: 256 SVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQ 315
Query: 773 LAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
A+ S H S+RR QP LP L P LP
Sbjct: 316 PASSSNH---------------SSRRGSLQAYTFEEQPT--LPVLLPT-------SSGLP 351
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTI 892
P WE + D GR +YVDH +RTTTW +PT AT
Sbjct: 352 PGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--------------------------- 384
Query: 893 ATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQS 952
E S+ S S G S+A +S S + + + L +
Sbjct: 385 -VETSQLTSSQSS-----------AGPQSQASTSDSGQQVTQPSEIEQ------GFLPKG 426
Query: 953 PAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINM 1012
V+ N F + H T +T + LK+ R + DL
Sbjct: 427 WEVRHAPNGRPFFIDHN--------TKTTTWEDPRLKIPAHLRGKTSLDTSNDLG----- 473
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE +T G+ F+++HN + T + DPR+
Sbjct: 474 ------PLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL 506
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 447 bits (1149), Expect = e-125
Identities = 277/777 (35%), Positives = 407/777 (52%), Gaps = 75/777 (9%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQ 889
PLPP WE R D GR +YV+H +R T W+RPT +G+IQ Q R +
Sbjct: 539 PLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAE-NGNIQLQAQ---RAFTTR 594
Query: 890 RTIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLL 949
R I+ E D+ S + ++ RE + ++Q
Sbjct: 595 RQISEETESVDN----------------------RESSENWEIIREDEATMYSNQAF--- 629
Query: 950 LQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNF 1009
P+ +N + T L +A ++ + +R + +
Sbjct: 630 ---PSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPT 686
Query: 1010 INMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQ 1069
+ + T LP GWE K D++G+S++VDHNSR TT+ P + Q + LT Q
Sbjct: 687 LPVLLPTSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTV--QATVETSQLTSSQS-- 742
Query: 1070 RLRSYSAGEASEVSRNRGASLLARPGHSLVAAIRSQHQHESLPLAYNDKIVAFLRQPNIF 1129
SAG S+ S + + +P S+ + LP + + PN
Sbjct: 743 -----SAGPQSQASTSDSGQQVTQP---------SEIEQGFLPKGWEVR-----HAPNGR 783
Query: 1130 EMLQERQPSLARNHTLREKIH-YIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQA 1188
+ R KI ++R G L DL L +EE +
Sbjct: 784 PFFIDHNTKTTTWEDPRLKIPAHLR-----GKTSLDTSNDLGPLPPGWEERTHT------ 832
Query: 1189 AFHPGYSFSPRCSPCSSPQNSPGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGP 1247
G F + + P L+ + P+ PY RD++ K F RKL+ + P
Sbjct: 833 ---DGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQN--DIP 887
Query: 1248 GKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
K ++ +RR +LE ++ ++M R + + +L++ F GE+GLDY G +RE+FFL+S+E+
Sbjct: 888 NKFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEM 947
Query: 1308 FNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPF 1366
FNPYYGLFEYSA D YT+QI+P S E+HL +F+F GR+ G+A+ H LLD FF RPF
Sbjct: 948 FNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPF 1007
Query: 1367 YKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGG 1426
YK +L P L D+E +D E++ SL+W+ +N+ T+ LDL F ++EE+FGQ + ELK+GG
Sbjct: 1008 YKMMLHKPITLHDMESVDSEYYNSLRWILENDPTE-LDLRFIIDEELFGQTHQHELKNGG 1066
Query: 1427 ANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAG 1486
+ VT KNKKEYI +++WR + +Q A GF+E++ L+ +FD ELEL++ G
Sbjct: 1067 SEIVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCG 1126
Query: 1487 TAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFA 1546
++D+NDWR +T+Y+ GY H VI+WFW AV ++E+R+RLLQFVTGTS VP GFA
Sbjct: 1127 LGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFA 1186
Query: 1547 ALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
L GSNG + F +E+WG LPRAHTCFNRLDLPPY S+ L++KL A+E T F
Sbjct: 1187 ELYGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGF 1243
Score = 65.1 bits (157), Expect = 5e-10
Identities = 83/339 (24%), Positives = 118/339 (34%), Gaps = 96/339 (28%)
Query: 721 SVDSAKISESTVFSSQDDEEE-ENSAFESVPDSMQ-------SPELDPESTNGAGPWQDE 772
SVD+ + SE+ +D+ N AF S P S + EL+ T +
Sbjct: 603 SVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEELNARLTIFGNSAVSQ 662
Query: 773 LAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
A+ S H S+RR QP LP L P LP
Sbjct: 663 PASSSNH---------------SSRRGSLQAYTFEEQPT--LPVLLPT-------SSGLP 698
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTI 892
P WE + D GR +YVDH +RTTTW +PT AT
Sbjct: 699 PGWEEKQDERGRSYYVDHNSRTTTWTKPTVQAT--------------------------- 731
Query: 893 ATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVNSQKITLLLQS 952
E S+ S S G S+A +S S + + + L +
Sbjct: 732 -VETSQLTSSQSS-----------AGPQSQASTSDSGQQVTQPSEIEQ------GFLPKG 773
Query: 953 PAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINM 1012
V+ N F + H T +T + LK+ R + DL
Sbjct: 774 WEVRHAPNGRPFFIDHN--------TKTTTWEDPRLKIPAHLRGKTSLDTSNDLG----- 820
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE +T G+ F+++HN + T + DPR+
Sbjct: 821 ------PLPPGWEERTHTDGRIFYINHNIKRTQWEDPRL 853
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 458 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 515
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 516 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 575
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 636 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 694
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 695 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 754
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 65.9 bits (159), Expect = 3e-10
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)
Query: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890
LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 318
Query: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945
I RS S AP G DS + + +L + SP NS K
Sbjct: 319 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 372
Query: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003
+T P ++ N F + H T +T + LK F + +
Sbjct: 373 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 417
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
+ +N + LP GWE + G++F++DHNS+ T + DPR+
Sbjct: 418 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 460
Score = 53.5 bits (127), Expect = 2e-06
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887
PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 130
Query: 888 IQRTIATERSEEDS 901
+R I+ + E S
Sbjct: 131 -RRHISEDLEPEPS 143
Score = 52.4 bits (124), Expect = 4e-06
Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)
Query: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
R P L SP S EG + P+ L N Q P P+ H T LP
Sbjct: 321 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 379
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860
P WE RI +GR F++DH +TTTW+ P
Sbjct: 380 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 374 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 433
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 434 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 492
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 551
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE RI GR FY+DH ++ T W+ P
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066
+ T LP GWE + D +G++++V+HN+R TT+ P + L +G N H
Sbjct: 259 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 318
Query: 1067 HLQRLRSYSA 1076
++R RS S+
Sbjct: 319 QIRRPRSLSS 328
Score = 37.4 bits (85), Expect = 0.12
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE K D G++++V+HN+R T + P +
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 559 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 616
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 617 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 676
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 677 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 736
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 737 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 795
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 796 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 855
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 856 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 915
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 916 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 951
Score = 71.6 bits (174), Expect = 6e-12
Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%)
Query: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795
EE N A +S+ ++ P P S +EL S ++ +P E S +
Sbjct: 278 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 334
Query: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855
+ R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT
Sbjct: 335 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 391
Query: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915
TW RP DG S + N I+ I RS S AP
Sbjct: 392 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 438
Query: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968
G DS + + +L + SP NS K+T P ++ N F + H
Sbjct: 439 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 498
Query: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028
T +T + LK F + ++ +N + LP GWE +
Sbjct: 499 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 538
Query: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051
G++F++DHNS+ T + DPR+
Sbjct: 539 HLDGRTFYIDHNSKITQWEDPRL 561
Score = 66.2 bits (160), Expect = 2e-10
Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886
PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R +
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 253
Query: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942
+I + E SE + E+ G G + +S S +E LS
Sbjct: 254 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 311
Query: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002
S+++ + S N E F+ L + R+ + S +
Sbjct: 312 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 349
Query: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058
L + T LP GWE + D +G++++V+HN+R TT+ P + L +G
Sbjct: 350 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 409
Query: 1059 PNHLTH--RQHLQRLRSYSA 1076
N H ++R RS S+
Sbjct: 410 TNSNNHLIEPQIRRPRSLSS 429
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 475 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 534
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 535 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 593
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 594 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 652
Score = 41.6 bits (96), Expect = 0.006
Identities = 63/286 (22%), Positives = 111/286 (38%), Gaps = 28/286 (9%)
Query: 218 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTD 277
KK +F DPY+K+S+ + AL ++K I T+NP W E + V+
Sbjct: 34 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 87
Query: 278 VLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDH---VSG 334
L EV F ++R FLG++ +P+ L +R ++ P H V G
Sbjct: 88 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 144
Query: 335 QLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGE-PRSEAPESSESWKP 393
L+ + DEE S + + N+ E P P E K
Sbjct: 145 FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEE-KV 203
Query: 394 EQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELL---AQVQKDIQ 450
+ LG + N++ + RP+ ++ D + + E A + +D++
Sbjct: 204 DNLGR-TYYVNHNNRTTQWHRPS--LMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE 260
Query: 451 PAPSA--------EELAEQLDLGEEASALLLEDGEAPASTKEEPLE 488
P PS E ++E++++ ++ L L A ++ P E
Sbjct: 261 PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE 306
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 438 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 495
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 496 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 555
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 556 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 616 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 674
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 675 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 734
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 735 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 794
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 795 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 71.6 bits (174), Expect = 6e-12
Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%)
Query: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795
EE N A +S+ ++ P P S +EL S ++ +P E S +
Sbjct: 157 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 213
Query: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855
+ R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT
Sbjct: 214 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 270
Query: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915
TW RP DG S + N I+ I RS S AP
Sbjct: 271 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 317
Query: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968
G DS + + +L + SP NS K+T P ++ N F + H
Sbjct: 318 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 377
Query: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028
T +T + LK F + ++ +N + LP GWE +
Sbjct: 378 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 417
Query: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051
G++F++DHNS+ T + DPR+
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRL 440
Score = 66.2 bits (160), Expect = 2e-10
Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886
PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R +
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 132
Query: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942
+I + E SE + E+ G G + +S S +E LS
Sbjct: 133 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 190
Query: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002
S+++ + S N E F+ L + R+ + S +
Sbjct: 191 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 228
Query: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058
L + T LP GWE + D +G++++V+HN+R TT+ P + L +G
Sbjct: 229 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 288
Query: 1059 PNHLTH--RQHLQRLRSYSA 1076
N H ++R RS S+
Sbjct: 289 TNSNNHLIEPQIRRPRSLSS 308
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 354 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 413
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 414 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 472
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 473 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 531
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 438 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 495
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 496 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 555
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 556 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 615
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 616 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 674
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 675 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 734
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 735 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 794
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 795 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 830
Score = 71.6 bits (174), Expect = 6e-12
Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%)
Query: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795
EE N A +S+ ++ P P S +EL S ++ +P E S +
Sbjct: 157 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 213
Query: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855
+ R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT
Sbjct: 214 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 270
Query: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915
TW RP DG S + N I+ I RS S AP
Sbjct: 271 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 317
Query: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968
G DS + + +L + SP NS K+T P ++ N F + H
Sbjct: 318 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 377
Query: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028
T +T + LK F + ++ +N + LP GWE +
Sbjct: 378 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 417
Query: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051
G++F++DHNS+ T + DPR+
Sbjct: 418 HLDGRTFYIDHNSKITQWEDPRL 440
Score = 66.2 bits (160), Expect = 2e-10
Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886
PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R +
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 132
Query: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942
+I + E SE + E+ G G + +S S +E LS
Sbjct: 133 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 190
Query: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002
S+++ + S N E F+ L + R+ + S +
Sbjct: 191 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 228
Query: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058
L + T LP GWE + D +G++++V+HN+R TT+ P + L +G
Sbjct: 229 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 288
Query: 1059 PNHLTH--RQHLQRLRSYSA 1076
N H ++R RS S+
Sbjct: 289 TNSNNHLIEPQIRRPRSLSS 308
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 354 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 413
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 414 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 472
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 473 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 531
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 551 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 608
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 609 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 668
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 669 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 728
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 729 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 787
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 788 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 847
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 848 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 907
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 908 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 943
Score = 71.6 bits (174), Expect = 6e-12
Identities = 85/323 (26%), Positives = 127/323 (39%), Gaps = 50/323 (15%)
Query: 740 EEENSAFESVPDSMQSPELDPESTNGAGPWQDELAAPSGHVERSP----EGLESPVAGPS 795
EE N A +S+ ++ P P S +EL S ++ +P E S +
Sbjct: 270 EEVNIAGDSLGLALPPPPASPGSRTSPQELSEEL---SRRLQITPDSNGEQFSSLIQREP 326
Query: 796 NRREGECPILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFYVDHVNRTT 855
+ R C + + V++ L P Y LP WE R D+ GR +YV+H NRTT
Sbjct: 327 SSRLRSCSV---TDAVAEQGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 383
Query: 856 TWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQRTIATERSEEDSGSQSCEQAPAGGGG 915
TW RP DG S + N I+ I RS S AP
Sbjct: 384 TWTRPIMQLAEDGASGSAT-------NSNNHLIEPQIRRPRSL--SSPTVTLSAPL---- 430
Query: 916 GGGSDSEAESS-QSSLDLRREGSLSPVNS----QKITLLLQSPA--VKFITNPEFFTVLH 968
G DS + + +L + SP NS K+T P ++ N F + H
Sbjct: 431 EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDH 490
Query: 969 ANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKT 1028
T +T + LK F + ++ +N + LP GWE +
Sbjct: 491 N--------TKTTTWEDPRLK-------FPVHMRSKTSLN-----PNDLGPLPPGWEERI 530
Query: 1029 DQQGKSFFVDHNSRATTFIDPRI 1051
G++F++DHNS+ T + DPR+
Sbjct: 531 HLDGRTFYIDHNSKITQWEDPRL 553
Score = 66.2 bits (160), Expect = 2e-10
Identities = 66/260 (25%), Positives = 109/260 (41%), Gaps = 37/260 (14%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPT---AAATPDGMRRSGSIQQMEQLNRRYQ 886
PLPP WE ++D+ GR +YV+H NRTT W RP+ ++ D R + + + R +
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRR 245
Query: 887 NIQRTIATERSE----EDSGSQSCEQAPAGGGGGGGSDSEAESSQSSLDLRREGSLSPVN 942
+I + E SE + E+ G G + +S S +E LS
Sbjct: 246 HISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE--LSEEL 303
Query: 943 SQKITLLLQSPAVKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQH 1002
S+++ + S N E F+ L + R+ + S +
Sbjct: 304 SRRLQITPDS-------NGEQFSSLIQREPSSRLRSCSVT---------------DAVAE 341
Query: 1003 NRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRL 1058
L + T LP GWE + D +G++++V+HN+R TT+ P + L +G
Sbjct: 342 QGHLPPPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSA 401
Query: 1059 PNHLTH--RQHLQRLRSYSA 1076
N H ++R RS S+
Sbjct: 402 TNSNNHLIEPQIRRPRSLSS 421
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 467 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 526
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 527 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 585
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 586 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 644
Score = 41.6 bits (96), Expect = 0.006
Identities = 63/286 (22%), Positives = 111/286 (38%), Gaps = 28/286 (9%)
Query: 218 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTD 277
KK +F DPY+K+S+ + AL ++K I T+NP W E + V+
Sbjct: 26 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 79
Query: 278 VLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDH---VSG 334
L EV F ++R FLG++ +P+ L +R ++ P H V G
Sbjct: 80 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 136
Query: 335 QLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGE-PRSEAPESSESWKP 393
L+ + DEE S + + N+ E P P E K
Sbjct: 137 FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEE-KV 195
Query: 394 EQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELL---AQVQKDIQ 450
+ LG + N++ + RP+ ++ D + + E A + +D++
Sbjct: 196 DNLGR-TYYVNHNNRTTQWHRPS--LMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE 252
Query: 451 PAPSA--------EELAEQLDLGEEASALLLEDGEAPASTKEEPLE 488
P PS E ++E++++ ++ L L A ++ P E
Sbjct: 253 PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQE 298
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 571 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 628
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 629 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 688
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 689 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 748
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 749 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 807
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 808 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 867
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 868 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 927
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 928 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 963
Score = 65.9 bits (159), Expect = 3e-10
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)
Query: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890
LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+
Sbjct: 379 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 431
Query: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945
I RS S AP G DS + + +L + SP NS K
Sbjct: 432 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 485
Query: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003
+T P ++ N F + H T +T + LK F + +
Sbjct: 486 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 530
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
+ +N + LP GWE + G++F++DHNS+ T + DPR+
Sbjct: 531 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 573
Score = 53.5 bits (127), Expect = 2e-06
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887
PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++
Sbjct: 186 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 243
Query: 888 IQRTIATERSEEDS 901
+R I+ + E S
Sbjct: 244 -RRHISEDLEPEPS 256
Score = 52.4 bits (124), Expect = 4e-06
Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)
Query: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
R P L SP S EG + P+ L N Q P P+ H T LP
Sbjct: 434 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 492
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860
P WE RI +GR F++DH +TTTW+ P
Sbjct: 493 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 520
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 487 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 546
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 547 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 605
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 606 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 664
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE RI GR FY+DH ++ T W+ P
Sbjct: 541 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 571
Score = 42.0 bits (97), Expect = 0.005
Identities = 81/381 (21%), Positives = 142/381 (37%), Gaps = 46/381 (12%)
Query: 218 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTD 277
KK +F DPY+K+S+ + AL ++K I T+NP W E + V+
Sbjct: 26 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 79
Query: 278 VLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDH---VSG 334
L EV F ++R FLG++ +P+ L +R ++ P H V G
Sbjct: 80 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 136
Query: 335 QLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGE-PRSEAPESSESWKP 393
L+ + DEE S + + N+ E P P E K
Sbjct: 137 FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEE-KV 195
Query: 394 EQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELL---AQVQKDIQ 450
+ LG + N++ + RP+ ++ D + + E A + +D++
Sbjct: 196 DNLGR-TYYVNHNNRTTQWHRPS--LMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE 252
Query: 451 PAPSA--------EELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEE 502
P PS E ++E++++ ++ L L A ++ P E R +
Sbjct: 253 PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPD 312
Query: 503 EKEQEEEGDVSTLEQGEGRLQLRA-----SVKRKSR--PCSLPVSELETVIASACGDPET 555
++ S+L Q E +LR+ +V + P S P + + G+ T
Sbjct: 313 SNGEQ----FSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTG-GEEPT 367
Query: 556 PRTHYIRIHTLLHSMPSAQGG 576
P Y+ H+ P G
Sbjct: 368 PSVAYV------HTTPGLPSG 382
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066
+ T LP GWE + D +G++++V+HN+R TT+ P + L +G N H
Sbjct: 372 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 431
Query: 1067 HLQRLRSYSA 1076
++R RS S+
Sbjct: 432 QIRRPRSLSS 441
Score = 37.4 bits (85), Expect = 0.12
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE K D G++++V+HN+R T + P +
Sbjct: 187 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 218
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 579 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 636
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 637 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 696
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 697 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 756
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 757 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 815
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 816 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 875
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 876 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 935
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 936 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 971
Score = 65.9 bits (159), Expect = 3e-10
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)
Query: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890
LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+
Sbjct: 387 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 439
Query: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945
I RS S AP G DS + + +L + SP NS K
Sbjct: 440 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 493
Query: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003
+T P ++ N F + H T +T + LK F + +
Sbjct: 494 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 538
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
+ +N + LP GWE + G++F++DHNS+ T + DPR+
Sbjct: 539 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 581
Score = 53.5 bits (127), Expect = 2e-06
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887
PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++
Sbjct: 194 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 251
Query: 888 IQRTIATERSEEDS 901
+R I+ + E S
Sbjct: 252 -RRHISEDLEPEPS 264
Score = 52.4 bits (124), Expect = 4e-06
Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)
Query: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
R P L SP S EG + P+ L N Q P P+ H T LP
Sbjct: 442 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 500
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860
P WE RI +GR F++DH +TTTW+ P
Sbjct: 501 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 528
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 495 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 554
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 555 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 613
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 614 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 672
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE RI GR FY+DH ++ T W+ P
Sbjct: 549 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 579
Score = 42.0 bits (97), Expect = 0.005
Identities = 81/381 (21%), Positives = 142/381 (37%), Gaps = 46/381 (12%)
Query: 218 KKGMFFNPDPYLKISIQPGKHSIFPALPHHGQERRSKIIGNTVNPIWQAEQFSFVSLPTD 277
KK +F DPY+K+S+ + AL ++K I T+NP W E + V+
Sbjct: 34 KKDIFGASDPYVKLSLYVADENRELALV------QTKTIKKTLNPKWNEEFYFRVNPSNH 87
Query: 278 VLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLERHAIGDRVVSYTLGRRLPTDH---VSG 334
L EV F ++R FLG++ +P+ L +R ++ P H V G
Sbjct: 88 RLLFEV---FDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKG 144
Query: 335 QLQFRFEITSSIHPDDEEISLSTEPESAQIQDSPMNNLMESGSGE-PRSEAPESSESWKP 393
L+ + DEE S + + N+ E P P E K
Sbjct: 145 FLRLKMAYMPKNGGQDEENSDQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEE-KV 203
Query: 394 EQLGEGSVPDGPGNQSIELSRPAEEAAVITEAGDQGMVSVGPEGAGELL---AQVQKDIQ 450
+ LG + N++ + RP+ ++ D + + E A + +D++
Sbjct: 204 DNLGR-TYYVNHNNRTTQWHRPS--LMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLE 260
Query: 451 PAPSA--------EELAEQLDLGEEASALLLEDGEAPASTKEEPLEEEATTQSRAGREEE 502
P PS E ++E++++ ++ L L A ++ P E R +
Sbjct: 261 PEPSEGGDVPEPWETISEEVNIAGDSLGLALPPPPASPGSRTSPQELSEELSRRLQITPD 320
Query: 503 EKEQEEEGDVSTLEQGEGRLQLRA-----SVKRKSR--PCSLPVSELETVIASACGDPET 555
++ S+L Q E +LR+ +V + P S P + + G+ T
Sbjct: 321 SNGEQ----FSSLIQREPSSRLRSCSVTDAVAEQGHLPPPSAPAGRARSSTVTG-GEEPT 375
Query: 556 PRTHYIRIHTLLHSMPSAQGG 576
P Y+ H+ P G
Sbjct: 376 PSVAYV------HTTPGLPSG 390
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066
+ T LP GWE + D +G++++V+HN+R TT+ P + L +G N H
Sbjct: 380 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 439
Query: 1067 HLQRLRSYSA 1076
++R RS S+
Sbjct: 440 QIRRPRSLSS 449
Score = 37.4 bits (85), Expect = 0.12
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE K D G++++V+HN+R T + P +
Sbjct: 195 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 226
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 458 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 515
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 516 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 575
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 636 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 694
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 695 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 754
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 65.9 bits (159), Expect = 3e-10
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)
Query: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890
LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 318
Query: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945
I RS S AP G DS + + +L + SP NS K
Sbjct: 319 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 372
Query: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003
+T P ++ N F + H T +T + LK F + +
Sbjct: 373 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 417
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
+ +N + LP GWE + G++F++DHNS+ T + DPR+
Sbjct: 418 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 460
Score = 53.5 bits (127), Expect = 2e-06
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887
PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 130
Query: 888 IQRTIATERSEEDS 901
+R I+ + E S
Sbjct: 131 -RRHISEDLEPEPS 143
Score = 52.4 bits (124), Expect = 4e-06
Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)
Query: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
R P L SP S EG + P+ L N Q P P+ H T LP
Sbjct: 321 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 379
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860
P WE RI +GR F++DH +TTTW+ P
Sbjct: 380 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 374 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 433
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 434 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 492
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 551
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE RI GR FY+DH ++ T W+ P
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066
+ T LP GWE + D +G++++V+HN+R TT+ P + L +G N H
Sbjct: 259 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 318
Query: 1067 HLQRLRSYSA 1076
++R RS S+
Sbjct: 319 QIRRPRSLSS 328
Score = 37.4 bits (85), Expect = 0.12
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE K D G++++V+HN+R T + P +
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 378 bits (971), Expect = e-104
Identities = 187/396 (47%), Positives = 266/396 (67%), Gaps = 5/396 (1%)
Query: 1210 PGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
P LQ + P+ PY R+F+ K F +KL+ P + ++ + R+++ E ++ ++M
Sbjct: 458 PRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPA--DIPNRFEMKLHRNNIFEESYRRIM 515
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+ R ++ + +L++ F E+GLDY G +RE+FFLLS+E+FNPYYGLFEYSA D YT+QI+
Sbjct: 516 SVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQIN 575
Query: 1329 PMSAFV-ENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEF 1387
P S E+HL +F F GR+ GLA+ H LLD FF RPFYK +L L+D+E +D E+
Sbjct: 576 PNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEY 635
Query: 1388 HQSLQWMKDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
+ SL+W+ +N+ T+ LDL F ++EE FGQ + +LK G+ VT +NK+EYI+ +++WR
Sbjct: 636 YNSLKWILENDPTE-LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWR 694
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
V +Q A + GF E++ L+ +FD ELEL++ G ++D+NDWR ++ Y+ GY
Sbjct: 695 FVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCP 754
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
H VI+WFW AV + E+R+RLLQFVTGTS VP GFA L GSNG + F IE+WG
Sbjct: 755 NHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEK 814
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
LPRAHTCFNRLDLPPY ++ L EKLL AVE F
Sbjct: 815 LPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGF 850
Score = 65.9 bits (159), Expect = 3e-10
Identities = 65/228 (28%), Positives = 93/228 (40%), Gaps = 40/228 (17%)
Query: 831 LPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQLNRRYQNIQR 890
LP WE R D+ GR +YV+H NRTTTW RP DG S + N I+
Sbjct: 266 LPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSAT-------NSNNHLIEP 318
Query: 891 TIATERSEEDSGSQSCEQAPAGGGGGGGSDSEAESS-QSSLDLRREGSLSPVNS----QK 945
I RS S AP G DS + + +L + SP NS K
Sbjct: 319 QIRRPRSL--SSPTVTLSAPL----EGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHK 372
Query: 946 ITLLLQSPA--VKFITNPEFFTVLHANYSAYRVFTSSTCLKHMILKVRRDARNFERYQHN 1003
+T P ++ N F + H T +T + LK F + +
Sbjct: 373 VTQSFLPPGWEMRIAPNGRPFFIDHN--------TKTTTWEDPRLK-------FPVHMRS 417
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
+ +N + LP GWE + G++F++DHNS+ T + DPR+
Sbjct: 418 KTSLN-----PNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRL 460
Score = 53.5 bits (127), Expect = 2e-06
Identities = 28/74 (37%), Positives = 44/74 (59%), Gaps = 5/74 (6%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRRSGSIQQMEQ--LNRRYQN 887
PLPP WE ++D+ GR +YV+H NRTT W RP+ +I+Q+ Q +RR+++
Sbjct: 73 PLPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSLMDV--SSESDNNIRQINQEAAHRRFRS 130
Query: 888 IQRTIATERSEEDS 901
+R I+ + E S
Sbjct: 131 -RRHISEDLEPEPS 143
Score = 52.4 bits (124), Expect = 4e-06
Identities = 33/88 (37%), Positives = 41/88 (46%), Gaps = 10/88 (11%)
Query: 782 RSPEGLESPVAGPSNRREG--ECPI-------LHNSQPVSQLPSLRPEHHHYPTIDEPLP 832
R P L SP S EG + P+ L N Q P P+ H T LP
Sbjct: 321 RRPRSLSSPTVTLSAPLEGAKDSPVRRAVKDTLSNPQSPQPSPYNSPKPQHKVT-QSFLP 379
Query: 833 PNWEARIDSHGRVFYVDHVNRTTTWQRP 860
P WE RI +GR F++DH +TTTW+ P
Sbjct: 380 PGWEMRIAPNGRPFFIDHNTKTTTWEDP 407
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 23/180 (12%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI-------------PLQNGRLPNHL 1062
T+ LP GWE++ G+ FF+DHN++ TT+ DPR+ P G LP
Sbjct: 374 TQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKTSLNPNDLGPLPPGW 433
Query: 1063 THRQHLQRLRSYSAGEASEVSRNRGASL----LARPGHSLVAAIRSQHQH----ESLPLA 1114
R HL R++ S++++ L + P + ++ + P
Sbjct: 434 EERIHLDG-RTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPAD 492
Query: 1115 YNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLS 1174
++ L + NIFE R S+ R L+ ++ +I E GL+ + LLS
Sbjct: 493 IPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARL-WIEFESEKGLDYGGVAREWFFLLS 551
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE RI GR FY+DH ++ T W+ P
Sbjct: 428 PLPPGWEERIHLDGRTFYIDHNSKITQWEDP 458
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/70 (32%), Positives = 38/70 (54%), Gaps = 6/70 (8%)
Query: 1013 FADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPL----QNGRLPNHLTH--RQ 1066
+ T LP GWE + D +G++++V+HN+R TT+ P + L +G N H
Sbjct: 259 YVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLIEP 318
Query: 1067 HLQRLRSYSA 1076
++R RS S+
Sbjct: 319 QIRRPRSLSS 328
Score = 37.4 bits (85), Expect = 0.12
Identities = 14/32 (43%), Positives = 22/32 (68%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE K D G++++V+HN+R T + P +
Sbjct: 74 LPPGWEEKVDNLGRTYYVNHNNRTTQWHRPSL 105
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 378 bits (971), Expect = e-104
Identities = 233/603 (38%), Positives = 327/603 (54%), Gaps = 47/603 (7%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1079
LP GWE + D G++++VDHN+R TT+ P+ PL G R+ R R Y
Sbjct: 351 LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQ-PLPPG------WERRVDDRRRVYY---- 399
Query: 1080 SEVSRNRGASLLARPGHSLVAAIRS-QHQHESLPLAYNDKIVAFLRQPNIFEMLQERQ-- 1136
V N + RP V Q Q L A +L ++ +
Sbjct: 400 --VDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGP 457
Query: 1137 --PSLARNHTLREKIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGY 1194
P + ++++++ NH + + + + + PL + Y
Sbjct: 458 LPPGWEKRVDSTDRVYFV----NHNTKTTQWEDPRT-------QGLQNEEPLPEGWEIRY 506
Query: 1195 S---------FSPRCSPCSSPQNSPGLQRASARAPS-PYRRDFEAKLRNFYRKLEAKGFG 1244
+ + R + P+N G + P Y R F KL +F ++
Sbjct: 507 TREGVRYFVDHNTRTTTFKDPRN--GKSSVTKGGPQIAYERGFRWKLAHFRYLCQSNAL- 563
Query: 1245 QGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLS 1304
P +K+ + R L E +F Q+MA +L+R +LYV F GEEGLDY G +RE+FFLLS
Sbjct: 564 --PSHVKINVSRQTLFEDSFQQIMALKPYDLRR-RLYVIFRGEEGLDYGGLAREWFFLLS 620
Query: 1305 QELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTR 1364
E+ NP Y LFEY+ + Y +QI+P S +HL +F F GR + +AL H +D F+
Sbjct: 621 HEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSL 680
Query: 1365 PFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELK 1423
PFYK +L + DLE +D EF+ SL W++DNNI + L++ F+V+ E+ G+VT +LK
Sbjct: 681 PFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLK 740
Query: 1424 SGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELV 1483
GG+N VTE+NK EYI M +WR RGV +QT+A + GF EVV + + FD +ELE++
Sbjct: 741 LGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVM 800
Query: 1484 IAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYE 1543
+ G E+DL DW+ NT YR + +I WFW V+ +NE R+RLLQFVTGT +P
Sbjct: 801 LCGMQEVDLADWQRNTVYRHYTRNSKQII-WFWQFVKETDNEVRMRLLQFVTGTCRLPLG 859
Query: 1544 GFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTF 1603
GFA L GSNG ++FCIEK GK T LPR+HTCFNRLDLPPY SY L EKLL A+EET F
Sbjct: 860 GFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF 919
Query: 1604 GLE 1606
G E
Sbjct: 920 GQE 922
Score = 66.6 bits (161), Expect = 2e-10
Identities = 87/346 (25%), Positives = 133/346 (38%), Gaps = 47/346 (13%)
Query: 573 AQGGSAAEEEDGA--EEESTLKDSSEKDGLSEVDTVAADPSALEEDREEPEGATPGTAHP 630
AQ G DG E+E+ SS S + + AL E+ E T A
Sbjct: 130 AQTGELTVVLDGLVIEQENITNCSS-----SPTIEIQENGDALHENGEPSARTTARLAVE 184
Query: 631 GHSG--GHFPS---LANGAAQ---DGDTHPSTGSESDSSPRQGGDHSCEGCDASCCSPSC 682
G +G H P+ + N +GD PS+ S+ + P+ S
Sbjct: 185 GTNGIDNHVPTSTLVQNSCCSYVVNGDNTPSSPSQVAARPKN------TPAPKPLASEPA 238
Query: 683 YSSSCYSTSCYSSSCYSASCYSPSCYNGNRFASHTRFSSVDSAKISESTVFSSQDDEEEE 742
+ +S ++ + ++ +P N + + ++V+ + E S E
Sbjct: 239 DDTVNGESSSFAPTDNASVTGTPVVSEENALSPNCTSTTVEDPPVQEILTSS------EN 292
Query: 743 NSAFESVPDSMQSPE---LDPESTNGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRRE 799
N S ++S L+P+++N E A R P+G PV S
Sbjct: 293 NECIPSTSAELESEARSILEPDTSNSRSSSAFEAAK-----SRQPDGCMDPVRQQSGNAN 347
Query: 800 GECPILHNSQPVSQLPSLRP---EHHHYPTIDE---PLPPNWEARIDSHGRVFYVDHVNR 853
E L + + P R +H+ T E PLPP WE R+D RV+YVDH R
Sbjct: 348 TET--LPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRRRVYYVDHNTR 405
Query: 854 TTTWQRPTAAATPDGMRRSGSIQQ----MEQLNRRYQNIQRTIATE 895
TTTWQRPT + + + Q M+Q N+RY +A E
Sbjct: 406 TTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAE 451
Score = 46.6 bits (109), Expect = 2e-04
Identities = 17/31 (54%), Positives = 23/31 (74%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE R+DS RV++V+H +TT W+ P
Sbjct: 457 PLPPGWEKRVDSTDRVYFVNHNTKTTQWEDP 487
Score = 38.9 bits (89), Expect = 0.040
Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 16/77 (20%)
Query: 995 RNFERYQHNRD-LVNFINMFADTRL--------------ELPRGWEIKTDQQGKSFFVDH 1039
RNFE++Q R+ L + F L LP GWE + D + +FV+H
Sbjct: 418 RNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNH 477
Query: 1040 NSRATTFIDPRIP-LQN 1055
N++ T + DPR LQN
Sbjct: 478 NTKTTQWEDPRTQGLQN 494
Score = 38.9 bits (89), Expect = 0.040
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 828 DEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
+EPLP WE R G ++VDH RTTT++ P
Sbjct: 495 EEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDP 527
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 375 bits (962), Expect = e-103
Identities = 190/385 (49%), Positives = 259/385 (67%), Gaps = 6/385 (1%)
Query: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Y RDF+AK++ F + P IK+ + R L E +F Q+M++S ++L+R +L+V
Sbjct: 483 YVRDFKAKVQYFRFWCQQLAM---PQHIKITVTRKTLFEDSFQQIMSFSPQDLRR-RLWV 538
Query: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
F GEEGLDY G +RE+FFLLS E+ NP Y LFEY+ D Y +QI+P S +HL++FR
Sbjct: 539 IFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFR 598
Query: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
F GR + +AL H +D F+ PFYK +L P L DLE +D EF+ SL W+K+NNI +
Sbjct: 599 FIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEEC 658
Query: 1403 -LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVR 1461
L++ F+V++E+ G++ +LK G N VTE+NK+EYI + +WR+ RGV +QT+A
Sbjct: 659 DLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFE 718
Query: 1462 GFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVER 1521
GF E++ + + FDA+ELE+++ G EIDLNDW+ + YR Y I WFW V+
Sbjct: 719 GFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKE 777
Query: 1522 FNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLP 1581
+NE+R+RLLQFVTGT +P GFA L GSNG ++FCIEK GK LPR+HTCFNRLDLP
Sbjct: 778 IDNEKRMRLLQFVTGTCRLPVGGFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLP 837
Query: 1582 PYPSYSMLYEKLLTAVEETSTFGLE 1606
PY SY L EKLL A+EET FG E
Sbjct: 838 PYKSYEQLKEKLLFAIEETEGFGQE 862
Score = 69.3 bits (168), Expect = 3e-11
Identities = 35/76 (46%), Positives = 48/76 (63%), Gaps = 5/76 (6%)
Query: 829 EPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPD----GMRRSGSIQQMEQLNRR 884
EPLPP WE R+D+ GR++YVDH RTTTWQRPT + + ++RS M+Q N+R
Sbjct: 317 EPLPPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQR 376
Query: 885 Y-QNIQRTIATERSEE 899
+ Q AT +S+E
Sbjct: 377 FIYGNQDLFATSQSKE 392
Score = 65.1 bits (157), Expect = 5e-10
Identities = 57/200 (28%), Positives = 79/200 (39%), Gaps = 16/200 (8%)
Query: 709 NGNRFASHTRFSSVDS-----AKISESTVFSSQDDEEEENSAFESVPDSMQSPELDPEST 763
+G+R TR S+ S A E+ S + N F+ P P P T
Sbjct: 165 DGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNSPSLSNGGFK--PSRPPRPSRPPPPT 222
Query: 764 NGAGPWQDELAAPSGHVERSPEGLESPVAGPSNRREGECPILHNSQPVSQLPSLRPEHHH 823
+ + + + S G P +N EG L +S RP +
Sbjct: 223 PRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEGATSGLIIPLTISGGSGPRPLN-- 280
Query: 824 YPTIDEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAATPDGMRR----SGSIQQME 879
P PLPP WE R+D HGRV+YVDHV + TTW RP P G R G I ++
Sbjct: 281 -PVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRP--EPLPPGWERRVDNMGRIYYVD 337
Query: 880 QLNRRYQNIQRTIATERSEE 899
R + T+ + R+ E
Sbjct: 338 HFTRTTTWQRPTLESVRNYE 357
Score = 47.8 bits (112), Expect = 9e-05
Identities = 18/31 (58%), Positives = 23/31 (74%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE R DS+GRV++V+H R T W+ P
Sbjct: 398 PLPPGWEKRTDSNGRVYFVNHNTRITQWEDP 428
Score = 45.1 bits (105), Expect = 6e-04
Identities = 18/31 (58%), Positives = 22/31 (70%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPR 1050
LP GWE++ G +FVDHN R TT+IDPR
Sbjct: 439 LPEGWEMRFTVDGIPYFVDHNRRTTTYIDPR 469
Score = 43.1 bits (100), Expect = 0.002
Identities = 17/31 (54%), Positives = 23/31 (74%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPR 1050
LP GWE +TD G+ +FV+HN+R T + DPR
Sbjct: 399 LPPGWEKRTDSNGRVYFVNHNTRITQWEDPR 429
Score = 38.5 bits (88), Expect = 0.053
Identities = 18/41 (43%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 1016 TRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG 1056
T+ LP GWE + DQ G+ ++VDH + TT+ P PL G
Sbjct: 283 TQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPE-PLPPG 322
Score = 36.6 bits (83), Expect = 0.20
Identities = 14/32 (43%), Positives = 21/32 (65%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWE + D G+ ++VDH +R TT+ P +
Sbjct: 319 LPPGWERRVDNMGRIYYVDHFTRTTTWQRPTL 350
Score = 36.2 bits (82), Expect = 0.26
Identities = 15/33 (45%), Positives = 20/33 (60%)
Query: 828 DEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
++PLP WE R G ++VDH RTTT+ P
Sbjct: 436 EKPLPEGWEMRFTVDGIPYFVDHNRRTTTYIDP 468
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 365 bits (936), Expect = e-100
Identities = 228/606 (37%), Positives = 318/606 (52%), Gaps = 56/606 (9%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEA 1079
LP GWE + G+ ++VDHN++ TT+ PL G R+ G
Sbjct: 302 LPAGWEQRELPNGRVYYVDHNTKTTTW---ERPLPPG------------WEKRTDPRGRF 346
Query: 1080 SEVSRNRGASLLARPGHSLVAAIRS-QHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPS 1138
V N + RP V Q Q L A FL Q + +
Sbjct: 347 YYVDHNTRTTTWQRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGP 406
Query: 1139 LARNHTLRE---KIHYIRTEGNHGLEKLSCDADLVILLSLFEEEIMSYVPLQAAFHPGYS 1195
L R+ +++Y+ NH +E+ + + A PG+
Sbjct: 407 LPPGWEKRQDNGRVYYV----NHNTRTTQ-----------WEDPRTQGMIQEPALPPGWE 451
Query: 1196 F-------------SPRCSPCSSPQNSPGLQRASAR-APSPYRRDFEAKLRNFYRKLEAK 1241
+ R + P+ PG + + + +P Y R F K F +
Sbjct: 452 MKYTSEGVRYFVDHNTRTTTFKDPR--PGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSN 509
Query: 1242 GFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFF 1301
P +K+ + R L E +F Q+M +L+R +LY+ GEEGLDY G +RE+FF
Sbjct: 510 AL---PSHVKISVSRQTLFEDSFQQIMNMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFF 565
Query: 1302 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAF 1361
LLS E+ NP Y LFEY+ + Y +QI+P S+ +HL +FRF GR + +AL H +D
Sbjct: 566 LLSHEVLNPMYCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAMALYHGKFIDTG 625
Query: 1362 FTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTER 1420
FT PFYK +L L DLE +D EF+ S+ W+K+NN+ + L+L F + E+ G+VT
Sbjct: 626 FTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKENNLEECGLELYFIQDMEILGKVTTH 685
Query: 1421 ELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDAREL 1480
ELK GG + +VTE+NK+EYI + WR RGV +QT+A + GF EV + FD +EL
Sbjct: 686 ELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKEL 745
Query: 1481 ELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSV 1540
EL++ G EID++DW+ +T YR Y I+WFW V+ +NE+R+RLLQFVTGT +
Sbjct: 746 ELMLCGMQEIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRL 804
Query: 1541 PYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEET 1600
P GFA L GSNG ++FCI+K GK T LPR+HTCFNRLDLPPY SY L EKLL A+EET
Sbjct: 805 PVGGFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEET 864
Query: 1601 STFGLE 1606
FG E
Sbjct: 865 EGFGQE 870
Score = 66.6 bits (161), Expect = 2e-10
Identities = 46/138 (33%), Positives = 65/138 (47%), Gaps = 24/138 (17%)
Query: 734 SSQDDEEEENSAFESVPDSMQSPELDPESTN---GAGPWQDELAAPSGHVERSPEGLESP 790
++ D EE S P + S +P +T+ A P + E + SG ++ P ++P
Sbjct: 241 TATDPEEPSVVGVTSPPAAPLSVTPNPNTTSLPAPATPAEGEEPSTSG-TQQLPAAAQAP 299
Query: 791 VAGPSNRREGECP------ILHNSQPVSQLPSLRPEHHHYPTIDEPLPPNWEARIDSHGR 844
A P+ + E P + HN++ T + PLPP WE R D GR
Sbjct: 300 DALPAGWEQRELPNGRVYYVDHNTKTT--------------TWERPLPPGWEKRTDPRGR 345
Query: 845 VFYVDHVNRTTTWQRPTA 862
+YVDH RTTTWQRPTA
Sbjct: 346 FYYVDHNTRTTTWQRPTA 363
Score = 44.7 bits (104), Expect = 7e-04
Identities = 19/31 (61%), Positives = 23/31 (74%), Gaps = 1/31 (3%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE R D+ GRV+YV+H RTT W+ P
Sbjct: 406 PLPPGWEKRQDN-GRVYYVNHNTRTTQWEDP 435
Score = 38.9 bits (89), Expect = 0.040
Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 827 IDEP-LPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
I EP LPP WE + S G ++VDH RTTT++ P
Sbjct: 441 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
Score = 36.2 bits (82), Expect = 0.26
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 16/71 (22%)
Query: 995 RNFERYQHNRD-----LVNFINMFA----------DTRLELPRGWEIKTDQQGKSFFVDH 1039
RN+E++Q R+ + +F F D LP GWE + D G+ ++V+H
Sbjct: 367 RNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGPLPPGWEKRQDN-GRVYYVNH 425
Query: 1040 NSRATTFIDPR 1050
N+R T + DPR
Sbjct: 426 NTRTTQWEDPR 436
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 360 bits (925), Expect = 5e-99
Identities = 187/388 (48%), Positives = 255/388 (65%), Gaps = 8/388 (2%)
Query: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Y RD KL+ +L + G +I+ + R+ + E ++ Q+M K+L++ +L V
Sbjct: 374 YERDLVQKLKVLRHELSLQQPQAGHCRIE--VSREEIFEESYRQIMKMRPKDLKK-RLMV 430
Query: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
F GEEGLDY G +RE+ +LL E+ NPYYGLF+YS ++ Y +QI+P S+ +HL +F
Sbjct: 431 KFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFH 490
Query: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
F GRI+GLA+ H + ++ FT PFYK LL P LSDLE +D E H+SL W+ +N+IT +
Sbjct: 491 FVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV 550
Query: 1403 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRG 1462
LD TF V FG++ + ELK G N VTE+NKKEY+ V WR RG+ Q AL +G
Sbjct: 551 LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKG 610
Query: 1463 FYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERF 1522
F E++ L+ FD +ELEL+I G +IDLNDW++NT + D + ++RWFW AVE F
Sbjct: 611 FNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETF 669
Query: 1523 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL---RRFCIEKWGKIT-SLPRAHTCFNRL 1578
+ E+R RLLQFVTG++ VP +GF AL+GS G R F I T +LP+AHTCFNR+
Sbjct: 670 DEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRI 729
Query: 1579 DLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
D+PPY SY LYEKLLTAVEET F +E
Sbjct: 730 DIPPYESYEKLYEKLLTAVEETCGFAVE 757
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/48 (47%), Positives = 31/48 (64%), Gaps = 3/48 (6%)
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
RDL N +N D LP GWE+++ G+ +FVDHN+R T F DPR+
Sbjct: 295 RDL-NSVN--CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 339
Score = 43.1 bits (100), Expect = 0.002
Identities = 17/31 (54%), Positives = 21/31 (67%)
Query: 830 PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
PLPP WE R GR+++VDH NRTT + P
Sbjct: 307 PLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 337
Score = 39.7 bits (91), Expect = 0.024
Identities = 17/41 (41%), Positives = 27/41 (65%)
Query: 1019 ELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNGRLP 1059
ELP G+E +T QG+ +F+ + +T+ DPRIP +G +P
Sbjct: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIP 275
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 360 bits (925), Expect = 5e-99
Identities = 187/388 (48%), Positives = 255/388 (65%), Gaps = 8/388 (2%)
Query: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Y RD KL+ +L + G +I+ + R+ + E ++ Q+M K+L++ +L V
Sbjct: 348 YERDLVQKLKVLRHELSLQQPQAGHCRIE--VSREEIFEESYRQIMKMRPKDLKK-RLMV 404
Query: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
F GEEGLDY G +RE+ +LL E+ NPYYGLF+YS ++ Y +QI+P S+ +HL +F
Sbjct: 405 KFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFH 464
Query: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
F GRI+GLA+ H + ++ FT PFYK LL P LSDLE +D E H+SL W+ +N+IT +
Sbjct: 465 FVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPV 524
Query: 1403 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRG 1462
LD TF V FG++ + ELK G N VTE+NKKEY+ V WR RG+ Q AL +G
Sbjct: 525 LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKG 584
Query: 1463 FYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERF 1522
F E++ L+ FD +ELEL+I G +IDLNDW++NT + D + ++RWFW AVE F
Sbjct: 585 FNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSN-IVRWFWQAVETF 643
Query: 1523 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGL---RRFCIEKWGKIT-SLPRAHTCFNRL 1578
+ E+R RLLQFVTG++ VP +GF AL+GS G R F I T +LP+AHTCFNR+
Sbjct: 644 DEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRI 703
Query: 1579 DLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
D+PPY SY LYEKLLTAVEET F +E
Sbjct: 704 DIPPYESYEKLYEKLLTAVEETCGFAVE 731
Score = 47.4 bits (111), Expect = 1e-04
Identities = 35/98 (35%), Positives = 42/98 (42%), Gaps = 9/98 (9%)
Query: 767 GPWQDELAAPSGHVERS-PEGLESPVAGPSNRREGECPILHNSQPVSQLPSLR-PEHHHY 824
G Q P GH PEG E +G+ LH VS R P +
Sbjct: 219 GSLQTPQNRPHGHQSPELPEGYEQRTTV-----QGQVYFLHTQTGVSTWHDPRIPRDLNS 273
Query: 825 PTIDE--PLPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
DE PLPP WE R GR+++VDH NRTT + P
Sbjct: 274 VNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDP 311
Score = 46.6 bits (109), Expect = 2e-04
Identities = 23/48 (47%), Positives = 31/48 (64%), Gaps = 3/48 (6%)
Query: 1004 RDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
RDL N +N D LP GWE+++ G+ +FVDHN+R T F DPR+
Sbjct: 269 RDL-NSVN--CDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRL 313
Score = 35.0 bits (79), Expect = 0.58
Identities = 15/34 (44%), Positives = 23/34 (67%)
Query: 1019 ELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIP 1052
ELP G+E +T QG+ +F+ + +T+ DPRIP
Sbjct: 235 ELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIP 268
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 360 bits (923), Expect = 8e-99
Identities = 188/399 (47%), Positives = 254/399 (63%), Gaps = 7/399 (1%)
Query: 1210 PGLQRASAR-APSPYRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVM 1268
PG + + + +P Y R F K F + P +K+ + R L E +F Q+M
Sbjct: 38 PGFESGTKQGSPGAYDRSFRWKYHQFRFLCHSNAL---PSHVKISVSRQTLFEDSFQQIM 94
Query: 1269 AYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQIS 1328
+L+R +LY+ GEEGLDY G +RE+FFLLS E+ NP Y LFEY+ + Y +QI+
Sbjct: 95 NMKPYDLRR-RLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQIN 153
Query: 1329 PMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFH 1388
P S+ +HL +FRF GR + +AL H +D FT PFYK +L L DLE +D EF+
Sbjct: 154 PASSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNKRPTLKDLESIDPEFY 213
Query: 1389 QSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWR 1447
S+ W+K+NN+ + L+L F + E+ G+VT ELK GG + +VTE+NK+EYI + WR
Sbjct: 214 NSIVWIKENNLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWR 273
Query: 1448 VERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHD 1507
RGV +QT+A + GF EV + FD +ELEL++ G EID++DW+ +T YR Y
Sbjct: 274 FTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYR-HYTK 332
Query: 1508 GHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS 1567
I+WFW V+ +NE+R+RLLQFVTGT +P GFA L GSNG ++FCI+K GK T
Sbjct: 333 NSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVGGFAELIGSNGPQKFCIDKVGKETW 392
Query: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
LPR+HTCFNRLDLPPY SY L EKLL A+EET FG E
Sbjct: 393 LPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQE 431
Score = 48.1 bits (113), Expect = 7e-05
Identities = 20/37 (54%), Positives = 26/37 (70%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIPLQNG 1056
LP GWE+K +G +FVDHN+R TTF DPR ++G
Sbjct: 7 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPRPGFESG 43
Score = 38.9 bits (89), Expect = 0.040
Identities = 18/35 (51%), Positives = 23/35 (65%), Gaps = 1/35 (2%)
Query: 827 IDEP-LPPNWEARIDSHGRVFYVDHVNRTTTWQRP 860
I EP LPP WE + S G ++VDH RTTT++ P
Sbjct: 2 IQEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 36
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 359 bits (921), Expect = 1e-98
Identities = 182/385 (47%), Positives = 253/385 (65%), Gaps = 5/385 (1%)
Query: 1223 YRRDFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYV 1282
Y+RD KL+ ++L + G +I+ + R+ + E ++ QVM K+L + +L +
Sbjct: 368 YKRDLVQKLKILRQELSQQQPQAGHCRIE--VSREEIFEESYRQVMKMRPKDLWK-RLMI 424
Query: 1283 TFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFR 1342
F GEEGLDY G +RE+ +LLS E+ NPYYGLF+YS +D YT+QI+P SA HL +F
Sbjct: 425 KFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFH 484
Query: 1343 FSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI 1402
F GRI+G+A+ H + +D FT PFYK LL L D+E +D + H SL W+ +N+IT +
Sbjct: 485 FVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGV 544
Query: 1403 LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRG 1462
LD TF V +G++ + ELK G + V E+NKKEY+ V WR RG+ Q AL +G
Sbjct: 545 LDHTFCVEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKG 604
Query: 1463 FYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERF 1522
F EV+ L+ FD +ELEL+I G +ID+NDW+ NT + D + +++WFW AVE F
Sbjct: 605 FNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKHCTPDSN-IVKWFWKAVEFF 663
Query: 1523 NNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKIT-SLPRAHTCFNRLDLP 1581
+ E+R RLLQFVTG+S VP +GF AL+G+ G R F I + T +LP+AHTCFNR+D+P
Sbjct: 664 DEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIP 723
Query: 1582 PYPSYSMLYEKLLTAVEETSTFGLE 1606
PY SY LYEKLLTA+EET F +E
Sbjct: 724 PYESYEKLYEKLLTAIEETCGFAVE 748
Score = 46.6 bits (109), Expect = 2e-04
Identities = 18/38 (47%), Positives = 25/38 (65%)
Query: 828 DEPLPPNWEARIDSHGRVFYVDHVNRTTTWQRPTAAAT 865
D LP WE R + GR+ Y++H+ RTT W+RPT A+
Sbjct: 156 DNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPAS 193
Score = 46.2 bits (108), Expect = 3e-04
Identities = 18/32 (56%), Positives = 23/32 (71%)
Query: 1020 LPRGWEIKTDQQGKSFFVDHNSRATTFIDPRI 1051
LP GWEI+ G+ +FVDHN+R T F DPR+
Sbjct: 299 LPPGWEIRNTATGRVYFVDHNNRTTQFTDPRL 330
Score = 45.8 bits (107), Expect = 3e-04
Identities = 31/84 (36%), Positives = 40/84 (47%), Gaps = 8/84 (9%)
Query: 784 PEGLESPVAGPSNRREGECPILHNSQPVSQLPSLR-PEHHHYPTIDE--PLPPNWEARID 840
PEG E ++G+ LH VS R P +E PLPP WE R
Sbjct: 254 PEGYEQRTT-----QQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNT 308
Query: 841 SHGRVFYVDHVNRTTTWQRPTAAA 864
+ GRV++VDH NRTT + P +A
Sbjct: 309 ATGRVYFVDHNNRTTQFTDPRLSA 332
Score = 36.6 bits (83), Expect = 0.20
Identities = 18/54 (33%), Positives = 34/54 (62%), Gaps = 2/54 (3%)
Query: 999 RYQHNRDLVNFINMFADTRLELPRGWEIKTDQQGKSFFVDHNSRATTFIDPRIP 1052
R Q +R+ ++ ++ T +LP G+E +T QQG+ +F+ + +T+ DPR+P
Sbjct: 234 RSQRHRNYMSRTHLH--TPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVP 285
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 305 bits (781), Expect = 2e-82
Identities = 161/383 (42%), Positives = 239/383 (62%), Gaps = 5/383 (1%)
Query: 1226 DFEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFV 1285
DF+ K + F ++LE G + + +RRDH+ E ++ ++ S +E+ +N+LY+ F
Sbjct: 3993 DFDVKRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELHRKSPEEM-KNRLYIVFE 4051
Query: 1286 GEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSG 1345
GEEG D G RE++ ++S+E+FNP Y LF S D T I+P S NHL +F+F G
Sbjct: 4052 GEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVG 4111
Query: 1346 RILGLALIHQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LD 1404
RI+ A+ LL+ +FTR FYK +L +D+E D F+Q L ++ +N+++ + D
Sbjct: 4112 RIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYD 4171
Query: 1405 LTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFY 1464
LTF+ + FG R+LK GAN VTE+NKKEY+ + + R+ + +Q A + GFY
Sbjct: 4172 LTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFY 4231
Query: 1465 EVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNN 1524
E++ RL+S+F +ELEL+I+G ID++D ++NTEY Y + I+WFW A+ F+
Sbjct: 4232 EIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQ 4290
Query: 1525 EQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPY 1583
R + LQFVTGTS VP +GFAAL G NG+++F I + + T LP AHTCFN+LDLP Y
Sbjct: 4291 ADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAY 4350
Query: 1584 PSYSMLYEKLLTAVEETST-FGL 1605
S+ L LL A++E S FGL
Sbjct: 4351 ESFEKLRHMLLLAIQECSEGFGL 4373
Score = 40.0 bits (92), Expect = 0.018
Identities = 41/174 (23%), Positives = 68/174 (39%), Gaps = 21/174 (12%)
Query: 365 QDSPMNNLMESGSGEP-RSEAPESSESWKPEQLGEGSVPDGPG---------------NQ 408
QDS N + GEP +E E ++ +G + DG +Q
Sbjct: 2284 QDSSSN---QQDPGEPGEAEVQEEDHDVTQTEVADGDIMDGEAETDSVVIAGQPEVLSSQ 2340
Query: 409 SIELSRPAEEAA--VITEAGDQGMVSVGPEGAGELLAQVQKDIQPAPSAEELAEQLDLGE 466
+++ E+ ++ G G ++ +GE +Q + APS A L
Sbjct: 2341 EMQVENELEDLIDELLERDGGSGNSTIIVSRSGEDESQEDVLMDEAPSNLSQASTLQANR 2400
Query: 467 EASALLLEDGEAPASTKEEPLEEEATTQSRAGREEEEKEQEEEGDVSTLEQGEG 520
E S +L+ + T+EE + + EEEE+E++EE D E EG
Sbjct: 2401 EDSMNILDPEDEEEHTQEEDSSGSNEDEDDSQDEEEEEEEDEEDDQEDDEGEEG 2454
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 270 bits (690), Expect = 8e-72
Identities = 147/348 (42%), Positives = 219/348 (62%), Gaps = 5/348 (1%)
Query: 1252 LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPY 1311
L++ RD + + V + +L++ + V F GEEG+ G RE+F +LS E+ NP
Sbjct: 555 LLVHRDSIFRSSCEVVSKANCAKLKQG-IAVRFHGEEGMG-QGVVREWFDILSNEIVNPD 612
Query: 1312 YGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1371
Y LF SA+ T T Q + S +HL +FRF+G+ILGLAL H+ L++ +FTR FYK +L
Sbjct: 613 YALFTQSADGT-TFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHIL 671
Query: 1372 RLPCDLSDLEYLDEEFHQSLQWMKDNNITDI-LDLTFTVNEEVFGQVTERELKSGGANTQ 1430
+P + D+ +D E+ ++LQW+ DN+I+D+ L+LTF+V +VFG + E LK GG +
Sbjct: 672 GIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSIL 731
Query: 1431 VTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEI 1490
VT+ NK EY++ + + R+ R + Q A ++GF+ + L+ +FD ELEL+++G EI
Sbjct: 732 VTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEI 791
Query: 1491 DLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRG 1550
D++DW NTEY GY VI+WFW VE E+R+ LLQFVTG+S VP+ GFA + G
Sbjct: 792 DVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMG 851
Query: 1551 SNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPSYSMLYEKLLTAV 1597
+GL+ F I + LP + TC N L LP YPS +L ++LL A+
Sbjct: 852 GSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 185 bits (470), Expect = 3e-46
Identities = 122/363 (33%), Positives = 187/363 (51%), Gaps = 18/363 (4%)
Query: 1250 IKLIIRRDHLLEGTFN--QVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
++L +RRDH+++ +++A + +LYV F GE+G+D G S+EFF L+ +E+
Sbjct: 520 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 579
Query: 1308 FNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFY 1367
FNP G+F Y + T +P S E F G +LGLA+ + +LD F Y
Sbjct: 580 FNPDIGMFTYDES-TKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 635
Query: 1368 KALLRLPCDLSDLEYLDEEFHQSLQWMKD--NNITDILDLTFTVNE-EVFGQVTERELKS 1424
+ L+ DL +QSL+ + + N+ D + +TF +++ ++FG +LK
Sbjct: 636 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKE 695
Query: 1425 GGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVV-DSRLVSVFDARELELV 1483
G +T +N+KE++ + + + V +Q +A RGF+ V +S L +F E+EL+
Sbjct: 696 NGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELL 755
Query: 1484 IAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYE 1543
I G+ +D TEY GGY ++IR FW V F +EQ+ LQF TGT P
Sbjct: 756 ICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG 815
Query: 1544 GFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETST 1602
G L + I K G T LP +HTCFN L LP Y S L E+LL A+
Sbjct: 816 GLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKG 868
Query: 1603 FGL 1605
FG+
Sbjct: 869 FGM 871
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 185 bits (470), Expect = 3e-46
Identities = 122/363 (33%), Positives = 187/363 (51%), Gaps = 18/363 (4%)
Query: 1250 IKLIIRRDHLLEGTFN--QVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
++L +RRDH+++ +++A + +LYV F GE+G+D G S+EFF L+ +E+
Sbjct: 500 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 559
Query: 1308 FNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFY 1367
FNP G+F Y + T +P S E F G +LGLA+ + +LD F Y
Sbjct: 560 FNPDIGMFTYDES-TKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 615
Query: 1368 KALLRLPCDLSDLEYLDEEFHQSLQWMKD--NNITDILDLTFTVNE-EVFGQVTERELKS 1424
+ L+ DL +QSL+ + + N+ D + +TF +++ ++FG +LK
Sbjct: 616 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKE 675
Query: 1425 GGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVV-DSRLVSVFDARELELV 1483
G +T +N+KE++ + + + V +Q +A RGF+ V +S L +F E+EL+
Sbjct: 676 NGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELL 735
Query: 1484 IAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYE 1543
I G+ +D TEY GGY ++IR FW V F +EQ+ LQF TGT P
Sbjct: 736 ICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG 795
Query: 1544 GFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETST 1602
G L + I K G T LP +HTCFN L LP Y S L E+LL A+
Sbjct: 796 GLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKG 848
Query: 1603 FGL 1605
FG+
Sbjct: 849 FGM 851
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 185 bits (470), Expect = 3e-46
Identities = 122/363 (33%), Positives = 187/363 (51%), Gaps = 18/363 (4%)
Query: 1250 IKLIIRRDHLLEGTFN--QVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQEL 1307
++L +RRDH+++ +++A + +LYV F GE+G+D G S+EFF L+ +E+
Sbjct: 523 LRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEI 582
Query: 1308 FNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFY 1367
FNP G+F Y + T +P S E F G +LGLA+ + +LD F Y
Sbjct: 583 FNPDIGMFTYDES-TKLFWFNPSSFETEGQ---FTLIGIVLGLAIYNNCILDVHFPMVVY 638
Query: 1368 KALLRLPCDLSDLEYLDEEFHQSLQWMKD--NNITDILDLTFTVNE-EVFGQVTERELKS 1424
+ L+ DL +QSL+ + + N+ D + +TF +++ ++FG +LK
Sbjct: 639 RKLMGKKGTFRDLGDSHPVLYQSLKDLLEYEGNVEDDMMITFQISQTDLFGNPMMYDLKE 698
Query: 1425 GGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVV-DSRLVSVFDARELELV 1483
G +T +N+KE++ + + + V +Q +A RGF+ V +S L +F E+EL+
Sbjct: 699 NGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRRGFHMVTNESPLKYLFRPEEIELL 758
Query: 1484 IAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYE 1543
I G+ +D TEY GGY ++IR FW V F +EQ+ LQF TGT P
Sbjct: 759 ICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG 818
Query: 1544 GFAALRGSNGLRRFCIEKWGKITS-LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETST 1602
G L + I K G T LP +HTCFN L LP Y S L E+LL A+
Sbjct: 819 GLGKL-------KMIIAKNGPDTERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKG 871
Query: 1603 FGL 1605
FG+
Sbjct: 872 FGM 874
>gi|87116668 hypothetical protein LOC9870 [Homo sapiens]
Length = 823
Score = 184 bits (468), Expect = 5e-46
Identities = 131/386 (33%), Positives = 199/386 (51%), Gaps = 22/386 (5%)
Query: 1227 FEAKLRNFYRKLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVG 1286
F+ K+ F R+L + K+ L + R LLE + +S + +N V F
Sbjct: 439 FQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKN-FEVVFQD 497
Query: 1287 EEGLDYSGPSREFFFLLSQELFNPYYGLF-EYSANDTYTVQISPMSAFVENHLEWFRFSG 1345
EE LD+ GP RE+F L+ + LF+ LF +S N+ V +P L+ + F+G
Sbjct: 498 EEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRP-AHLRLKMYEFAG 556
Query: 1346 RILGLALI-------HQYLLDAFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDNN 1398
R++G L ++ L+ A FTR F ++ L E D EF++S NN
Sbjct: 557 RLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNN 616
Query: 1399 ITDILDLTFTVNEEVF---GQVTER-ELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQ 1454
++L F EE + GQ+ + EL +GGA T VT NK Y+ + ++R+ V +
Sbjct: 617 DMSEMELVFA--EEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKE 674
Query: 1455 QTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGG-YHDGHLVIR 1513
+ E ++G E+V L+++FD ELEL++ GT +I ++D++ + GG +H V+R
Sbjct: 675 EVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMR 734
Query: 1514 WFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHT 1573
WFW V E+ RLLQF TG+S +P GFAAL S F I ++LP AHT
Sbjct: 735 WFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPS-----FQIIAAPTHSTLPTAHT 789
Query: 1574 CFNRLDLPPYPSYSMLYEKLLTAVEE 1599
CFN+L LP Y SY ++ L A+ E
Sbjct: 790 CFNQLCLPTYDSYEEVHRMLQLAISE 815
>gi|190341084 HECT domain containing 2 isoform a [Homo sapiens]
Length = 776
Score = 179 bits (454), Expect = 2e-44
Identities = 138/456 (30%), Positives = 223/456 (48%), Gaps = 44/456 (9%)
Query: 1176 FEEEIMSYVPLQAAFHPGYSF--SPRCSPCSSPQNSPGLQRASARAPSPYRRDFEAKLRN 1233
F + ++ L +H +F S R S C P + A +RD E ++ N
Sbjct: 340 FYNSTLDHIDLMEEYHTWQNFGNSHRFSFCQYP-----FVISVAAKKIIIQRDSEQQMIN 394
Query: 1234 FYRK--LEAKGFGQGPGK----IKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGE 1287
R+ ++ Q P + + +RR HL+ + ++ + R +L++ KL VTFVGE
Sbjct: 395 IARQSLVDKVSRRQRPDMNILFLNMKVRRTHLVSDSLDE-LTRKRADLKK-KLKVTFVGE 452
Query: 1288 EGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRI 1347
GLD G ++E+F LL +++F+P YG+F Y + S+F ++ FR G +
Sbjct: 453 AGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDS----HCHWFSSFKCDNYSEFRLVGIL 508
Query: 1348 LGLALIHQYLLDAFFTRPFYKALLRLP------------CDLS--DLEYLDEEFHQSLQW 1393
+GLA+ + LD F YK LL P C+++ DL + E L
Sbjct: 509 MGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVDDLCQIMPELAHGLSE 568
Query: 1394 M--KDNNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERG 1451
+ + N+ + TF V +E FG + LK GG VT +N+KEY++ + + +
Sbjct: 569 LLSHEGNVEEDFYSTFQVFQEEFGIIKSYNLKPGGDKISVTNQNRKEYVQLYTDFLLNKS 628
Query: 1452 VVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLV 1511
+ +Q A GF+ V S + + E+E+++ G+ ++D++ + +T+Y GY L
Sbjct: 629 IYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPDLDMHALQRSTQY-DGYAKTDLT 687
Query: 1512 IRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITS-LPR 1570
I++FW V F + + +LL F TG+ VP G A L F I K T+ LP
Sbjct: 688 IKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADL-------NFKISKNETSTNCLPV 740
Query: 1571 AHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1606
AHTCFN+L LPPY S L +KL+ + + FGLE
Sbjct: 741 AHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 776
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 176 bits (447), Expect = 1e-43
Identities = 110/357 (30%), Positives = 182/357 (50%), Gaps = 14/357 (3%)
Query: 1252 LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPY 1311
L++RR++++ G +V+ ++ + L V FVGE+ +D G +EFF L+ +EL +P
Sbjct: 703 LVVRRENIV-GDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPK 761
Query: 1312 YGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1371
YG+F Y D+ + S F ++ L F G I GLA+ + ++D F YK LL
Sbjct: 762 YGMFRY-YEDSRLIWFSD-KTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLL 817
Query: 1372 RLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVNEEVFGQVTERELKSGGAN 1428
+ L DL+ L + +S+Q + D ++I + L FT+ E FG +EL GA+
Sbjct: 818 KKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGAD 877
Query: 1429 TQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTA 1488
T V ++N++E+++ V + + V +A GF++V +++ +F EL+ ++ G
Sbjct: 878 TAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 937
Query: 1489 EIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAAL 1548
D + NTEY+G Y H I+ FW E++ + L F+TG+ +P +
Sbjct: 938 NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIP------I 991
Query: 1549 RGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605
G L+ G LP +HTCFN LDLP Y L KL+ A++ F L
Sbjct: 992 LGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 176 bits (447), Expect = 1e-43
Identities = 110/357 (30%), Positives = 182/357 (50%), Gaps = 14/357 (3%)
Query: 1252 LIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPY 1311
L++RR++++ G +V+ ++ + L V FVGE+ +D G +EFF L+ +EL +P
Sbjct: 711 LVVRRENIV-GDAMEVLRKTKNIDYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPK 769
Query: 1312 YGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALL 1371
YG+F Y D+ + S F ++ L F G I GLA+ + ++D F YK LL
Sbjct: 770 YGMFRY-YEDSRLIWFSD-KTFEDSDL--FHLIGVICGLAIYNCTIVDLHFPLALYKKLL 825
Query: 1372 RLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTFTVNEEVFGQVTERELKSGGAN 1428
+ L DL+ L + +S+Q + D ++I + L FT+ E FG +EL GA+
Sbjct: 826 KKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGAD 885
Query: 1429 TQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTA 1488
T V ++N++E+++ V + + V +A GF++V +++ +F EL+ ++ G
Sbjct: 886 TAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT 945
Query: 1489 EIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAAL 1548
D + NTEY+G Y H I+ FW E++ + L F+TG+ +P +
Sbjct: 946 NYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQFLLFLTGSDRIP------I 999
Query: 1549 RGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605
G L+ G LP +HTCFN LDLP Y L KL+ A++ F L
Sbjct: 1000 LGMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAIDHNEGFSL 1056
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 176 bits (447), Expect = 1e-43
Identities = 130/393 (33%), Positives = 190/393 (48%), Gaps = 37/393 (9%)
Query: 1247 PGKIKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYVTFVG-----EEGLDYSGPSREFFF 1301
P + IRR +LE + Q+ S+ + + + V FV E G+D G +EF
Sbjct: 678 PHVTHITIRRSRMLEDGYEQLRQLSQHAM-KGVIRVKFVNDLGVDEAGIDQDGVFKEFLE 736
Query: 1302 LLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAF 1361
+ + +F+P LF+ ++ D + SP S EN+L+ F F G++LG A+ ++D
Sbjct: 737 EIIKRVFDPALNLFKTTSGDE-RLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVP 795
Query: 1362 FTRPFYKALLR-----LPCDLSDLEYLDEEFHQSLQWMK--DNNITDILDLTFTVNEEVF 1414
F F LL + +L LD EF+++L +K D +ITD L LT + +E+V
Sbjct: 796 FASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITD-LGLTLSYDEDVM 854
Query: 1415 GQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALVRGFYEVVDSRLVSV 1474
GQ+ EL GG VT +NK YI M +R+ + QT AL+ GF ++ + +
Sbjct: 855 GQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRM 914
Query: 1475 FDARELELVIAG-TAEIDLNDWRNNTEYRGGYHDGHLVIRWFW-AAVERFNNEQRLRLLQ 1532
F EL+ +I+G AEIDL D + +T Y GG+H H VI W W F ++R L+
Sbjct: 915 FSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLK 974
Query: 1533 FVTGTSSVPYEGFAALRGSNGLR--------------------RFCIEKWGKITSLPRAH 1572
FVT S P GFA L+ +R F I K LP +
Sbjct: 975 FVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1034
Query: 1573 TCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605
TCFN L LP Y S+L EKL A+ + F L
Sbjct: 1035 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1067
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,245,063
Number of Sequences: 37866
Number of extensions: 3471776
Number of successful extensions: 25728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 233
Number of HSP's successfully gapped in prelim test: 539
Number of HSP's that attempted gapping in prelim test: 16910
Number of HSP's gapped (non-prelim): 5728
length of query: 1606
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1490
effective length of database: 13,855,062
effective search space: 20644042380
effective search space used: 20644042380
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.