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Search of human proteins with 91206450
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|91206450 ankyrin and armadillo repeat containing [Homo
sapiens]
(1363 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens] 2709 0.0
gi|31657114 armadillo repeat containing 4 [Homo sapiens] 86 2e-16
gi|189409124 armadillo repeat containing 3 [Homo sapiens] 70 1e-11
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 68 5e-11
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 68 5e-11
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 68 5e-11
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 67 9e-11
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 65 3e-10
gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens] 65 4e-10
gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens] 65 4e-10
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 62 4e-09
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 62 4e-09
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 62 4e-09
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 62 4e-09
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 62 4e-09
gi|224589129 karyopherin 7 [Homo sapiens] 62 5e-09
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 60 1e-08
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 59 2e-08
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 59 2e-08
gi|18079216 CASK interacting protein 1 [Homo sapiens] 57 9e-08
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 57 9e-08
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 57 9e-08
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 57 9e-08
gi|4504811 junction plakoglobin [Homo sapiens] 57 1e-07
gi|12056468 junction plakoglobin [Homo sapiens] 57 1e-07
gi|50511945 cajalin 2 isoform a [Homo sapiens] 57 2e-07
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 56 2e-07
gi|4504897 karyopherin alpha 2 [Homo sapiens] 55 5e-07
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 54 8e-07
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 54 1e-06
>gi|91206450 ankyrin and armadillo repeat containing [Homo sapiens]
Length = 1363
Score = 2709 bits (7023), Expect = 0.0
Identities = 1363/1363 (100%), Positives = 1363/1363 (100%)
Query: 1 MSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSISLEANYDQSSS 60
MSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSISLEANYDQSSS
Sbjct: 1 MSQMNNVGFSTAILLTPVDPTALLDYREVHQMIRELAIGIYCLNQIPSISLEANYDQSSS 60
Query: 61 CQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRAIMDIDPDGKPQTNK 120
CQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRAIMDIDPDGKPQTNK
Sbjct: 61 CQLPPAYYDTRIGQILINIDYMLKALWHGIYMPKEKRARFSELWRAIMDIDPDGKPQTNK 120
Query: 121 DIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYAENIMLKLTFST 180
DIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYAENIMLKLTFST
Sbjct: 121 DIFSEFSSAGLTDITKDPDFNEIYDEDVNEDPTYDPNSPEETAVFMKYAENIMLKLTFST 180
Query: 181 TQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQKHFEKKKDIRR 240
TQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQKHFEKKKDIRR
Sbjct: 181 TQIQQYENVFIFETGYWLTNAIKYNQDYLDICTYQRLQQRLYLQKKIIQKHFEKKKDIRR 240
Query: 241 GIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFSDDKVKTERELPPFIYGRDFKCQNFH 300
GIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFSDDKVKTERELPPFIYGRDFKCQNFH
Sbjct: 241 GIGYLKLICFLIPFLLSLKKKMKVPYLSSLLQPFSDDKVKTERELPPFIYGRDFKCQNFH 300
Query: 301 YKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTFIEDSGYKEYYSIPVME 360
YKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTFIEDSGYKEYYSIPVME
Sbjct: 301 YKENQYFHVHGGIEFDISTPSIENALEDFQKNLEKIRDCAANTFIEDSGYKEYYSIPVME 360
Query: 361 FHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLTDAQLHEQFKKKLGFKR 420
FHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLTDAQLHEQFKKKLGFKR
Sbjct: 361 FHGKSYYVIYFELETFYQQLYKTQWWGAINEIVNNLRLKRLPLTDAQLHEQFKKKLGFKR 420
Query: 421 AMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQ 480
AMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQ
Sbjct: 421 AMKCKSIPFGMKSAVERGLSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQ 480
Query: 481 LCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAA 540
LCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAA
Sbjct: 481 LCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAA 540
Query: 541 FYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIK 600
FYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIK
Sbjct: 541 FYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIK 600
Query: 601 GNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLAN 660
GNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLAN
Sbjct: 601 GNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLAN 660
Query: 661 DQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINL 720
DQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINL
Sbjct: 661 DQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINL 720
Query: 721 LVCDEPEVHSRCAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLC 780
LVCDEPEVHSRCAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLC
Sbjct: 721 LVCDEPEVHSRCAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLC 780
Query: 781 IGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPP 840
IGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPP
Sbjct: 781 IGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPP 840
Query: 841 LVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAV 900
LVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAV
Sbjct: 841 LVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAV 900
Query: 901 ALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICE 960
ALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICE
Sbjct: 901 ALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICE 960
Query: 961 GNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLL 1020
GNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLL
Sbjct: 961 GNGIAPLVRLLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLL 1020
Query: 1021 RNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYAL 1080
RNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYAL
Sbjct: 1021 RNHPSPNIKVEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYAL 1080
Query: 1081 TLFAFNNRFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLS 1140
TLFAFNNRFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLS
Sbjct: 1081 TLFAFNNRFQQYLILESGIMTISIFERFLESTVETEKAMAAFQIVVLAKVIRDMDHITLS 1140
Query: 1141 ARGVTILVDSLYSVQTSTIVLTGNLIASLAHSRAGIPEAFTTLGTIQRLCYHLYSGIEEV 1200
ARGVTILVDSLYSVQTSTIVLTGNLIASLAHSRAGIPEAFTTLGTIQRLCYHLYSGIEEV
Sbjct: 1141 ARGVTILVDSLYSVQTSTIVLTGNLIASLAHSRAGIPEAFTTLGTIQRLCYHLYSGIEEV 1200
Query: 1201 RAACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLV 1260
RAACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLV
Sbjct: 1201 RAACSSALGYLTYNANAFRILLKECRNKPNQFIRIKNNISRDASINPAFLKEFQMQQTLV 1260
Query: 1261 GLPSLSLEKNGGPSIIPIFKRGKEHRRKLKPKIQPKDSLTLLPPVTNFMGLFKATKKTKD 1320
GLPSLSLEKNGGPSIIPIFKRGKEHRRKLKPKIQPKDSLTLLPPVTNFMGLFKATKKTKD
Sbjct: 1261 GLPSLSLEKNGGPSIIPIFKRGKEHRRKLKPKIQPKDSLTLLPPVTNFMGLFKATKKTKD 1320
Query: 1321 SHNIFSFSSTITSDITNVSRPRIVCLNQLGKHVQKANPEPAEG 1363
SHNIFSFSSTITSDITNVSRPRIVCLNQLGKHVQKANPEPAEG
Sbjct: 1321 SHNIFSFSSTITSDITNVSRPRIVCLNQLGKHVQKANPEPAEG 1363
>gi|31657114 armadillo repeat containing 4 [Homo sapiens]
Length = 1044
Score = 86.3 bits (212), Expect = 2e-16
Identities = 114/471 (24%), Positives = 207/471 (43%), Gaps = 38/471 (8%)
Query: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
LV+ L+ + ++A+ S+ LA + I D G + LINLL++ ++K + ++
Sbjct: 457 LVKYLKGGNQTATVIALCSMRDFSLAQETCQLAIRDVGGLEVLINLLETDEVKCKIGSLK 516
Query: 694 LLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRC--AVILYDIAQCEN-KDVIAK 750
+L IS + +V+ GG+P ++N+L D P +C A + ++A+ + + V+ +
Sbjct: 517 ILKEISHNPQIRQNIVDLGGLPIMVNIL--DSPHKSLKCLAAETIANVAKFKRARRVVRQ 574
Query: 751 YNGIPSLINLLNLNIENVL-----------VNVMNCIRVL---CIGNENNQRAVREHKGL 796
+ GI L+ LL+ ++ V V C + C + N+ A+R+ G+
Sbjct: 575 HGGITKLVALLDCAHDSTKPAQSSLYEARDVEVARCGALALWSCSKSHTNKEAIRKAGGI 634
Query: 797 PYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKG 856
P L R L + + + + E + + + AI E I LV + +Q
Sbjct: 635 PLLARLLKTSHENMLIPVVGTLQECASE-ENYRAAIKAERIIENLVKNLNSENEQLQEHC 693
Query: 857 AMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYM 916
AMA+ A L L K L LL D KE+ A A+ ++ ++ +
Sbjct: 694 AMAIYQCAEDKETRDLVRLHGGL-KPLASLLN--NTDNKERLAAVTGAIWKCSISKEN-V 749
Query: 917 AEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQIC--EGNGIAPLVRLLRIS 974
+ Y I ++ + + + V V AL + + +N++ + GI PLV LL
Sbjct: 750 TKFREYKAIETLVGLLTDQPEEVLVNVVGALGECCQERENRVIVRKCGGIQPLVNLL--V 807
Query: 975 TIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAF 1034
I + L++V +AVG+ + P S + + +L LL+N P P++K A+
Sbjct: 808 GINQALLVNVTKAVGACAV------EPESMMIIDRLDGVRLLWSLLKN-PHPDVKASAAW 860
Query: 1035 SLA-CIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFA 1084
+L CI D + G E ++ LL S K++ A+T A
Sbjct: 861 ALCPCIKNAKDAGEMVRSFVGGLEL--IVNLLKSDNKEVLASVCAAITNIA 909
Score = 48.1 bits (113), Expect = 6e-05
Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 712 GGIPSLINLLVCDEPEV-HSRCAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLV 770
GG+ ++NLL D EV S CA I EN VI + +P L L N N +
Sbjct: 881 GGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRH 940
Query: 771 NVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRD 824
++ I C+ N+ A EHK + L+R+L S+ + ++ A+ ++ D
Sbjct: 941 HLAEAISRCCMWG-RNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLSED 993
Score = 45.1 bits (105), Expect = 5e-04
Identities = 72/315 (22%), Positives = 122/315 (38%), Gaps = 19/315 (6%)
Query: 632 KTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKT 691
K L +L K R+ AV C + + + I L+ LL ++
Sbjct: 717 KPLASLLNNTDNKERLAAVTGAIWKCSISKENVTKFREYKAIETLVGLLTDQPEEVLVNV 776
Query: 692 VGLLSNISTHKSAVHALVEAGGIPSLINLLV-------CDEPEVHSRCAVILYDIAQCEN 744
VG L + + + GGI L+NLLV + + CAV + E+
Sbjct: 777 VGALGECCQERENRVIVRKCGGIQPLVNLLVGINQALLVNVTKAVGACAV------EPES 830
Query: 745 KDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQ-RAVREHKG-LPYLIRF 802
+I + +G+ L +LL +V + + CI N + VR G L ++
Sbjct: 831 MMIIDRLDGVRLLWSLLKNPHPDVKASAAWAL-CPCIKNAKDAGEMVRSFVGGLELIVNL 889
Query: 803 LSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVES 862
L SD+ + A AAI + +D + + I G +P L L ++ A A+
Sbjct: 890 LKSDNKEVLASVCAAITNIAKDQENLA-VITDHGVVPLLSKLANTNNNKLRHHLAEAISR 948
Query: 863 LASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGY 922
+ AF E L++ LK+ +V A AL+ L+ + M E
Sbjct: 949 CCMWGR-NRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLS-EDADNCITMHENGAV 1006
Query: 923 SFIINMLLSPSAKMQ 937
+++M+ SP +Q
Sbjct: 1007 KLLLDMVGSPDQDLQ 1021
Score = 32.0 bits (71), Expect = 4.2
Identities = 29/157 (18%), Positives = 65/157 (41%), Gaps = 8/157 (5%)
Query: 671 GTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHS 730
G + ++NLLKS ++ ++NI+ + + + + G +P L L + ++
Sbjct: 881 GGLELIVNLLKSDNKEVLASVCAAITNIAKDQENLAVITDHGVVPLLSKLANTNNNKLRH 940
Query: 731 RCAVILYDIAQC----ENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENN 786
A I++C N+ ++ + L+ L N NV + L + +N
Sbjct: 941 HLAEA---ISRCCMWGRNRVAFGEHKAVAPLVRYLKSNDTNVHRATAQALYQLS-EDADN 996
Query: 787 QRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGR 823
+ E+ + L+ + S L+ ++ I+ + R
Sbjct: 997 CITMHENGAVKLLLDMVGSPDQDLQEAAAGCISNIRR 1033
>gi|189409124 armadillo repeat containing 3 [Homo sapiens]
Length = 872
Score = 70.5 bits (171), Expect = 1e-11
Identities = 97/468 (20%), Positives = 203/468 (43%), Gaps = 24/468 (5%)
Query: 622 KLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLK 681
K + EL + L ++L E R A M ++ ND + + + + ++I L
Sbjct: 60 KTTLLELGAVEPLTKLLTHEDKIVRRNATMIFGILASNNDVK-KLLRELDVMNSVIAQLA 118
Query: 682 SSKIKLQCKTVGL-LSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIA 740
+ + + L L+N+S ++ + E GG+ LI LL +P+V +Y++
Sbjct: 119 PEEEVVIHEFASLCLANMSAEYTSKVQIFEHGGLEPLIRLLSSPDPDVKKNSMECIYNLV 178
Query: 741 ---QCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLP 797
QC K + + N IP +++LL + + + + V+ ++ ++ +R+++GL
Sbjct: 179 QDFQCRAK--LQELNAIPPILDLLKSEYPVIQLLALKTLGVIA-NDKESRTMLRDNQGLD 235
Query: 798 YLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGA 857
+LI+ L + + + A+ ++ + I G + L++ + I K A
Sbjct: 236 HLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLKKLLSFAENSTIPDIQKNA 295
Query: 858 MAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMA 917
+ A+++ +K F E+ + K L+ LL + K + A+ A+ + K
Sbjct: 296 AKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAASQAISAMCENS--GSKDFF 353
Query: 918 EQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIA 977
G +I +L S + +++ A+ L+ + + N E +GI PL+ LL S+
Sbjct: 354 NNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAAEADGIDPLINLL--SSKR 411
Query: 978 EGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLA 1037
+G + + + ++ + N + + + +I LR S N V+ +LA
Sbjct: 412 DGAIANAATVLTNMAMQEPLRLN------IQNHDIMHAIISPLR---SANTVVQSKAALA 462
Query: 1038 CIVLGNDV-LQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFA 1084
DV + +L + G E ++ LL S ++ A +A+ + A
Sbjct: 463 VTATACDVEARTELRNSGGLE--PLVELLRSKNDEVRKHASWAVMVCA 508
Score = 60.1 bits (144), Expect = 1e-08
Identities = 71/366 (19%), Positives = 162/366 (44%), Gaps = 16/366 (4%)
Query: 598 DIKGNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVIC 657
D+K N S+ + V + + + EL ++++L+ E +++A+ +L VI
Sbjct: 165 DVKKN-----SMECIYNLVQDFQCRAKLQELNAIPPILDLLKSEYPVIQLLALKTLGVI- 218
Query: 658 LANDQYWRCIL-DAGTIPALINLLKSSKIK-LQCKTVGLLSNISTHKSAVHALVEAGGIP 715
AND+ R +L D + LI +L++ ++ L + + +++N + + + GG+
Sbjct: 219 -ANDKESRTMLRDNQGLDHLIKILETKELNDLHIEALAVIANCLEDMDTMVQIQQTGGLK 277
Query: 716 SLINLLVCDE-PEVHSRCAVILYDIA-QCENKDVIAKYNGIPSLINLLNLNIENVLVNVM 773
L++ P++ A + A EN+ + + L+ LL + +
Sbjct: 278 KLLSFAENSTIPDIQKNAAKAITKAAYDPENRKLFHEQEVEKCLVALLGSENDGTKIAAS 337
Query: 774 NCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIA 833
I +C + + ++G+P LI+ L SD++ ++ ++ A+A + N +A A
Sbjct: 338 QAISAMC--ENSGSKDFFNNQGIPQLIQLLKSDNEEVREAAALALANLTTCNPANANAAA 395
Query: 834 MEGAIPPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQID 893
I PL+ L K+ A + ++A L + + ++ L++
Sbjct: 396 EADGIDPLINLLSSKRDGAIANAATVLTNMAMQEPL-RLNIQNHDIMHAIISPLRSANTV 454
Query: 894 VKEQGAVALWALAGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRM 953
V+ + A+A+ A A ++ + + G ++ +L S + +++ AV+ + D +
Sbjct: 455 VQSKAALAVTATACD-VEARTELRNSGGLEPLVELLRSKNDEVRKHASWAVMVCAGD-EL 512
Query: 954 HQNQIC 959
N++C
Sbjct: 513 TANELC 518
Score = 39.3 bits (90), Expect = 0.026
Identities = 63/297 (21%), Positives = 130/297 (43%), Gaps = 16/297 (5%)
Query: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQIS 851
E K ++ L+S + + A + AI + +E + + GA+ PL L +
Sbjct: 23 ESKKAATVVLMLNSPEEEILAKACEAIYKFALKGEENKTTLLELGAVEPLTKLLTHEDKI 82
Query: 852 VQMKGAMAVESLASHNALIQKAFLEKS-LTKYLLKLLKAFQIDVKEQGAVALWALAGQ-T 909
V+ M LAS+N ++K E + + +L ++ + E ++ L ++ + T
Sbjct: 83 VRRNATMIFGILASNND-VKKLLRELDVMNSVIAQLAPEEEVVIHEFASLCLANMSAEYT 141
Query: 910 LKQQKYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVR 969
K Q + E G +I +L SP ++ E + L +D + + ++ E N I P++
Sbjct: 142 SKVQIF--EHGGLEPLIRLLSSPDPDVKKNSMECIYNLVQDFQC-RAKLQELNAIPPILD 198
Query: 970 LLRISTIAEGTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIK 1029
LL+ + VI+ + +GV ++ S+ + D LI++L ++
Sbjct: 199 LLK-------SEYPVIQLLALKTLGVI-ANDKESRTMLRDNQGLDHLIKILETKELNDLH 250
Query: 1030 VEVAFSLACIVLGNDVLQKDLHENEGFEYADVLYLLHSTEKDICLRAGYALTLFAFN 1086
+E +A + D + + + + G + + + +ST DI A A+T A++
Sbjct: 251 IEALAVIANCLEDMDTMVQ-IQQTGGLKKL-LSFAENSTIPDIQKNAAKAITKAAYD 305
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 68.2 bits (165), Expect = 5e-11
Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H +A +V + L A + +G TPLH+AA+ SL+ LL
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAG----AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A + K G P+H AA YDN + + L K S ATA+N TPL +AA +
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAAKKNQM 621
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
L + GA +G +HL+ HT+++ ++
Sbjct: 622 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Score = 64.7 bits (156), Expect = 6e-10
Identities = 46/161 (28%), Positives = 72/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N++ I L N + N + QG TPLHLA+Q + LL
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETN----IVTKQGVTPLHLASQEGHTDMVTLLLDK 663
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
A+ +S K G +H AA D V + L + + +A + TPL++A G +
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG---ADQDAHTKLGYTPLIVACHYGNV 720
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ +L GAN G +H + HT ++ +++
Sbjct: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761
Score = 53.5 bits (127), Expect = 1e-06
Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
++I E+G T H AA ++I+ L + VT +G T LH+AA+A +
Sbjct: 401 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD----VTNIRGETALHMAARAGQV 456
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
E CLL + A + P+H A+ I+ L + + +A N TPL
Sbjct: 457 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ---HMAHPDAATTNGYTPL 513
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
++A G +D L GA KG +H++ +V K +++
Sbjct: 514 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Score = 50.8 bits (120), Expect = 9e-06
Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
T LH+AA T LL +A+ G+ P+H A + + ++ L + S+
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-- 403
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TP+ +AA G L+ + L GA+ T+I+G +H++ EV++ +
Sbjct: 404 -QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Query: 621 IK 622
++
Sbjct: 463 LR 464
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/132 (25%), Positives = 58/132 (43%), Gaps = 3/132 (2%)
Query: 495 TFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRK 554
T G TPLH+AA ++ LL A + + G P+H A+ N ++ L +
Sbjct: 208 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 267
Query: 555 DPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 614
+ +A + TPL AA SG ++ L GA G + +H++ H
Sbjct: 268 GGQI---DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 615 EVLKYIIKLNIP 626
E +K++++ P
Sbjct: 325 ECVKHLLQHKAP 336
Score = 40.4 bits (93), Expect = 0.012
Identities = 31/138 (22%), Positives = 61/138 (44%), Gaps = 9/138 (6%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G LHLAA+ + LL + + K+G +H A+ ++ L ++ ++
Sbjct: 43 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
A ++N TPL +AA +D ++YL GAN G + +++ H + +
Sbjct: 103 ---NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 159
Query: 619 YII------KLNIPELPV 630
++ K+ +P L +
Sbjct: 160 ILLENDTKGKVRLPALHI 177
Score = 39.3 bits (90), Expect = 0.026
Identities = 31/125 (24%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
IN ++ G H AA V ++ +L V+ +G T LH+A+ A E
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT----KKGNTALHIASLAGQAEV 91
Query: 515 TVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLL 574
L+ A+ + G+ P++ AA +++ ++ L + ++ AT E+ TPL +
Sbjct: 92 VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN--QSTAT-EDGFTPLAV 148
Query: 575 AATSG 579
A G
Sbjct: 149 ALQQG 153
Score = 38.9 bits (89), Expect = 0.034
Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G TPLH+A + ++ L+ A + G PIH AAF ++ I++ L + S
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS- 435
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
+ T T L +AA +G ++ ++ L GA + +H++ TE+++
Sbjct: 436 --PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQ 493
Query: 619 YIIK 622
+++
Sbjct: 494 LLLQ 497
Score = 38.5 bits (88), Expect = 0.044
Identities = 43/203 (21%), Positives = 81/203 (39%), Gaps = 38/203 (18%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
S+++ + + G T H A+L + ++ L +N + G TPL++AAQ +
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS----QNGFTPLYMAAQENHI 122
Query: 513 ETTVCLLCSKADYTLSEKRGWMPI-----------------------------HFAAFYD 543
+ LL + A+ + + + G+ P+ H AA D
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 182
Query: 544 NVCIIIALCRKD-----PSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTD 598
+ L + D S + T E+ TPL +AA G ++ L + GA T
Sbjct: 183 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 242
Query: 599 IKGNNIIHLSVLTFHTEVLKYII 621
G +H++ +T ++K ++
Sbjct: 243 RNGITPLHVASKRGNTNMVKLLL 265
Score = 34.3 bits (77), Expect = 0.84
Identities = 18/57 (31%), Positives = 29/57 (50%)
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+N L LAA G + +Q L G++ KGN +H++ L EV+K ++K
Sbjct: 41 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK 97
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 68.2 bits (165), Expect = 5e-11
Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H +A +V + L A + +G TPLH+AA+ SL+ LL
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAG----AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A + K G P+H AA YDN + + L K S ATA+N TPL +AA +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAAKKNQM 642
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
L + GA +G +HL+ HT+++ ++
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Score = 64.7 bits (156), Expect = 6e-10
Identities = 46/161 (28%), Positives = 72/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N++ I L N + N + QG TPLHLA+Q + LL
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETN----IVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
A+ +S K G +H AA D V + L + + +A + TPL++A G +
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG---ADQDAHTKLGYTPLIVACHYGNV 741
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ +L GAN G +H + HT ++ +++
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Score = 53.5 bits (127), Expect = 1e-06
Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
++I E+G T H AA ++I+ L + VT +G T LH+AA+A +
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD----VTNIRGETALHMAARAGQV 477
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
E CLL + A + P+H A+ I+ L + + +A N TPL
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ---HMAHPDAATTNGYTPL 534
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
++A G +D L GA KG +H++ +V K +++
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 50.8 bits (120), Expect = 9e-06
Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
T LH+AA T LL +A+ G+ P+H A + + ++ L + S+
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-- 424
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TP+ +AA G L+ + L GA+ T+I+G +H++ EV++ +
Sbjct: 425 -QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 621 IK 622
++
Sbjct: 484 LR 485
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/132 (25%), Positives = 58/132 (43%), Gaps = 3/132 (2%)
Query: 495 TFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRK 554
T G TPLH+AA ++ LL A + + G P+H A+ N ++ L +
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 555 DPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 614
+ +A + TPL AA SG ++ L GA G + +H++ H
Sbjct: 289 GGQI---DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 615 EVLKYIIKLNIP 626
E +K++++ P
Sbjct: 346 ECVKHLLQHKAP 357
Score = 40.4 bits (93), Expect = 0.012
Identities = 31/138 (22%), Positives = 61/138 (44%), Gaps = 9/138 (6%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G LHLAA+ + LL + + K+G +H A+ ++ L ++ ++
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
A ++N TPL +AA +D ++YL GAN G + +++ H + +
Sbjct: 124 ---NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 619 YII------KLNIPELPV 630
++ K+ +P L +
Sbjct: 181 ILLENDTKGKVRLPALHI 198
Score = 39.3 bits (90), Expect = 0.026
Identities = 31/125 (24%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
IN ++ G H AA V ++ +L V+ +G T LH+A+ A E
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT----KKGNTALHIASLAGQAEV 112
Query: 515 TVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLL 574
L+ A+ + G+ P++ AA +++ ++ L + ++ AT E+ TPL +
Sbjct: 113 VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN--QSTAT-EDGFTPLAV 169
Query: 575 AATSG 579
A G
Sbjct: 170 ALQQG 174
Score = 38.9 bits (89), Expect = 0.034
Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G TPLH+A + ++ L+ A + G PIH AAF ++ I++ L + S
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS- 456
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
+ T T L +AA +G ++ ++ L GA + +H++ TE+++
Sbjct: 457 --PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQ 514
Query: 619 YIIK 622
+++
Sbjct: 515 LLLQ 518
Score = 38.5 bits (88), Expect = 0.044
Identities = 43/203 (21%), Positives = 81/203 (39%), Gaps = 38/203 (18%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
S+++ + + G T H A+L + ++ L +N + G TPL++AAQ +
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS----QNGFTPLYMAAQENHI 143
Query: 513 ETTVCLLCSKADYTLSEKRGWMPI-----------------------------HFAAFYD 543
+ LL + A+ + + + G+ P+ H AA D
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 544 NVCIIIALCRKD-----PSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTD 598
+ L + D S + T E+ TPL +AA G ++ L + GA T
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 599 IKGNNIIHLSVLTFHTEVLKYII 621
G +H++ +T ++K ++
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLL 286
Score = 34.3 bits (77), Expect = 0.84
Identities = 18/57 (31%), Positives = 29/57 (50%)
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+N L LAA G + +Q L G++ KGN +H++ L EV+K ++K
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK 118
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 68.2 bits (165), Expect = 5e-11
Identities = 49/160 (30%), Positives = 74/160 (46%), Gaps = 7/160 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H +A +V + L A + +G TPLH+AA+ SL+ LL
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAG----AAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A + K G P+H AA YDN + + L K S ATA+N TPL +AA +
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS---PHATAKNGYTPLHIAAKKNQM 642
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
L + GA +G +HL+ HT+++ ++
Sbjct: 643 QIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Score = 64.7 bits (156), Expect = 6e-10
Identities = 46/161 (28%), Positives = 72/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N++ I L N + N + QG TPLHLA+Q + LL
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETN----IVTKQGVTPLHLASQEGHTDMVTLLLDK 684
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
A+ +S K G +H AA D V + L + + +A + TPL++A G +
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHG---ADQDAHTKLGYTPLIVACHYGNV 741
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ +L GAN G +H + HT ++ +++
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Score = 53.5 bits (127), Expect = 1e-06
Identities = 44/170 (25%), Positives = 73/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
++I E+G T H AA ++I+ L + VT +G T LH+AA+A +
Sbjct: 422 ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPD----VTNIRGETALHMAARAGQV 477
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
E CLL + A + P+H A+ I+ L + + +A N TPL
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ---HMAHPDAATTNGYTPL 534
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
++A G +D L GA KG +H++ +V K +++
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 50.8 bits (120), Expect = 9e-06
Identities = 32/122 (26%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
T LH+AA T LL +A+ G+ P+H A + + ++ L + S+
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASI-- 424
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TP+ +AA G L+ + L GA+ T+I+G +H++ EV++ +
Sbjct: 425 -QAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 621 IK 622
++
Sbjct: 484 LR 485
Score = 47.4 bits (111), Expect = 1e-04
Identities = 34/132 (25%), Positives = 58/132 (43%), Gaps = 3/132 (2%)
Query: 495 TFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRK 554
T G TPLH+AA ++ LL A + + G P+H A+ N ++ L +
Sbjct: 229 TTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 555 DPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 614
+ +A + TPL AA SG ++ L GA G + +H++ H
Sbjct: 289 GGQI---DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 615 EVLKYIIKLNIP 626
E +K++++ P
Sbjct: 346 ECVKHLLQHKAP 357
Score = 40.4 bits (93), Expect = 0.012
Identities = 31/138 (22%), Positives = 61/138 (44%), Gaps = 9/138 (6%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G LHLAA+ + LL + + K+G +H A+ ++ L ++ ++
Sbjct: 64 GLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
A ++N TPL +AA +D ++YL GAN G + +++ H + +
Sbjct: 124 ---NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVA 180
Query: 619 YII------KLNIPELPV 630
++ K+ +P L +
Sbjct: 181 ILLENDTKGKVRLPALHI 198
Score = 39.3 bits (90), Expect = 0.026
Identities = 31/125 (24%), Positives = 56/125 (44%), Gaps = 7/125 (5%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
IN ++ G H AA V ++ +L V+ +G T LH+A+ A E
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT----KKGNTALHIASLAGQAEV 112
Query: 515 TVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLL 574
L+ A+ + G+ P++ AA +++ ++ L + ++ AT E+ TPL +
Sbjct: 113 VKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN--QSTAT-EDGFTPLAV 169
Query: 575 AATSG 579
A G
Sbjct: 170 ALQQG 174
Score = 38.9 bits (89), Expect = 0.034
Identities = 30/124 (24%), Positives = 58/124 (46%), Gaps = 3/124 (2%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G TPLH+A + ++ L+ A + G PIH AAF ++ I++ L + S
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS- 456
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
+ T T L +AA +G ++ ++ L GA + +H++ TE+++
Sbjct: 457 --PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQ 514
Query: 619 YIIK 622
+++
Sbjct: 515 LLLQ 518
Score = 38.5 bits (88), Expect = 0.044
Identities = 43/203 (21%), Positives = 81/203 (39%), Gaps = 38/203 (18%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
S+++ + + G T H A+L + ++ L +N + G TPL++AAQ +
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQS----QNGFTPLYMAAQENHI 143
Query: 513 ETTVCLLCSKADYTLSEKRGWMPI-----------------------------HFAAFYD 543
+ LL + A+ + + + G+ P+ H AA D
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 544 NVCIIIALCRKD-----PSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTD 598
+ L + D S + T E+ TPL +AA G ++ L + GA T
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTA 263
Query: 599 IKGNNIIHLSVLTFHTEVLKYII 621
G +H++ +T ++K ++
Sbjct: 264 RNGITPLHVASKRGNTNMVKLLL 286
Score = 34.3 bits (77), Expect = 0.84
Identities = 18/57 (31%), Positives = 29/57 (50%)
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+N L LAA G + +Q L G++ KGN +H++ L EV+K ++K
Sbjct: 62 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVK 118
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 67.4 bits (163), Expect = 9e-11
Identities = 48/169 (28%), Positives = 76/169 (44%), Gaps = 7/169 (4%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N + +GYT H +A + L + ++ +T +G TPLH+AA+ LE
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLS----ITTKKGFTPLHVAAKYGKLEVA 581
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL A + K G P+H AA YDN + + L + S A A+N TPL +A
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGAS---PHAAAKNGYTPLHIA 638
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLN 624
A +D L GA+ +G +HL+ H +++ ++ N
Sbjct: 639 AKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Score = 58.9 bits (141), Expect = 3e-08
Identities = 52/207 (25%), Positives = 85/207 (41%), Gaps = 14/207 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N G H AA V ++ L N VN ++ G TPLHLAAQ +
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN----LSNKSGLTPLHLAAQEDRVNVA 713
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
L+ A K G+ P+H Y N+ I+ L + + A +N TPL A
Sbjct: 714 EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHS---AKVNAKTKNGYTPLHQA 770
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTLV 635
A G I L A+ + + GN + ++ L YI ++ ++ +T+
Sbjct: 771 AQQGHTHIINVLLQNNASPNELTVNGNTALGIA------RRLGYISVVDTLKIVTEETMT 824
Query: 636 EMLQCESYKRRMMAVMSLEVICLANDQ 662
E +K + M+ EV+ +++D+
Sbjct: 825 TTTVTEKHKMNVPETMN-EVLDMSDDE 850
Score = 55.5 bits (132), Expect = 4e-07
Identities = 31/122 (25%), Positives = 62/122 (50%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
T LH+AA + LL KA+ G+ P+H A + + ++ L + S+
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI-- 426
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TP+ +AA G ++ + L GA+ T+++G +H++ + EV++Y+
Sbjct: 427 -QAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 621 IK 622
++
Sbjct: 486 VQ 487
Score = 50.1 bits (118), Expect = 1e-05
Identities = 43/160 (26%), Positives = 69/160 (43%), Gaps = 7/160 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
G+T H A NR+ ++ L + VT S G TP+H+AA + L+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQA---VTES-GLTPIHVAAFMGHVNIVSQLMHH 455
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
A + RG +H AA ++ L + + EA A++ TPL ++A G
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGA---QVEAKAKDDQTPLHISARLGKA 512
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
D +Q L GA+ G +HLS H +V +++
Sbjct: 513 DIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLL 552
Score = 49.7 bits (117), Expect = 2e-05
Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 3/126 (2%)
Query: 503 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAE 562
LH+AA+ + LL + + + K G+ P+H AA Y N+ + L + ++ +
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAV---D 262
Query: 563 ATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
TA N TPL +A+ G + ++ L GA G +H + H +V++ ++
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLD 322
Query: 623 LNIPEL 628
P L
Sbjct: 323 RAAPIL 328
Score = 44.3 bits (103), Expect = 8e-04
Identities = 33/124 (26%), Positives = 53/124 (42%), Gaps = 3/124 (2%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G TPLH+A + ++ LL A + G PIH AAF +V I+ L S
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
E T L +AA SG + ++YL GA +H+S ++++
Sbjct: 460 NTTNVRGE---TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
Query: 619 YIIK 622
+++
Sbjct: 517 QLLQ 520
Score = 40.8 bits (94), Expect = 0.009
Identities = 43/224 (19%), Positives = 87/224 (38%), Gaps = 19/224 (8%)
Query: 494 VTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCR 553
V G TPLH+AA ++ LL A + + P+H A+ N ++ L
Sbjct: 230 VESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
Query: 554 KDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFH 613
+ + +A + TPL A SG ++ L A G + +H++ H
Sbjct: 290 RGAKI---DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDH 346
Query: 614 TEVLKYIIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTI 673
++ +++ N+P V + L ++ + + + +LD
Sbjct: 347 LNCVQLLLQHNVPVDDVTNDYLTALHVAAH--------------CGHYKVAKVLLDKKAN 392
Query: 674 PALINLLKSSKIKLQCK--TVGLLSNISTHKSAVHALVEAGGIP 715
P L + + + CK + ++ + H +++ A+ E+G P
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436
Score = 40.8 bits (94), Expect = 0.009
Identities = 35/171 (20%), Positives = 78/171 (45%), Gaps = 7/171 (4%)
Query: 452 SSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACS 511
S++ + + ++G T H AA ++ + L + + G TPLH+AA+
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPH----AAAKNGYTPLHIAAKKNQ 643
Query: 512 LETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTP 571
++ LL AD ++G +H AA +V ++ L ++ ++ + ++ TP
Sbjct: 644 MDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV---NLSNKSGLTP 700
Query: 572 LLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
L LAA ++ + L + GA+ G +H+ + +++ ++++
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751
Score = 40.4 bits (93), Expect = 0.012
Identities = 31/138 (22%), Positives = 63/138 (45%), Gaps = 9/138 (6%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G LHLA++ +E LL +A+ + K+G +H A+ ++ L ++
Sbjct: 74 GLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
A ++N TPL +AA L+ +++L GA+ G + +++ H +V+
Sbjct: 134 ---NAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 619 YII------KLNIPELPV 630
++ K+ +P L +
Sbjct: 191 LLLENDTKGKVRLPALHI 208
Score = 39.3 bits (90), Expect = 0.026
Identities = 25/116 (21%), Positives = 58/116 (50%), Gaps = 3/116 (2%)
Query: 506 AAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATA 565
AA+A LE + + + D + + G +H A+ +V ++ L +++ ++ +A
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANV---DAAT 104
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
+ T L +A+ +G + ++ L + GAN G ++++ H EV+K+++
Sbjct: 105 KKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLL 160
Score = 37.4 bits (85), Expect = 0.099
Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 11/135 (8%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
+ ++ + + G T H A+L + ++ L VN + G TPL++AAQ L
Sbjct: 98 ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS----QNGFTPLYMAAQENHL 153
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKD-------PSLLEAEATA 565
E LL + A +L+ + G+ P+ A + ++ L D P+L A
Sbjct: 154 EVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKD 213
Query: 566 ENQCTPLLLAATSGA 580
+ + LLL + A
Sbjct: 214 DTKAAALLLQNDNNA 228
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 65.5 bits (158), Expect = 3e-10
Identities = 54/189 (28%), Positives = 85/189 (44%), Gaps = 10/189 (5%)
Query: 434 AVERGLSAVFHTF-SRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRR 492
AVER + V +RK S +N DE +T H AA + S L N VN+
Sbjct: 478 AVERRVRGVVELLLARKIS---VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVD 534
Query: 493 FVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALC 552
F +G TP+H+A Q LL D +L K W+P+H+AA+ ++ I+ L
Sbjct: 535 F----EGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHL-PIVKLL 589
Query: 553 RKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTF 612
K P + T + + TPL LAA G + L + ++ + +H++ T
Sbjct: 590 AKQPGVSVNAQTLDGR-TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETG 648
Query: 613 HTEVLKYII 621
HT + ++
Sbjct: 649 HTSTARLLL 657
Score = 44.7 bits (104), Expect = 6e-04
Identities = 33/133 (24%), Positives = 61/133 (45%), Gaps = 5/133 (3%)
Query: 494 VTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCII-IALC 552
+ G + LHLA +A E LL + A+ LS +RG P+H A ++ + L
Sbjct: 433 LALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLA 492
Query: 553 RKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTF 612
RK + A E+Q T L AA +G + + L A+ + D +G +H++
Sbjct: 493 RK----ISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHG 548
Query: 613 HTEVLKYIIKLNI 625
+++ +++ +
Sbjct: 549 QENIVRILLRRGV 561
Score = 42.4 bits (98), Expect = 0.003
Identities = 41/175 (23%), Positives = 71/175 (40%), Gaps = 8/175 (4%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNA-NFKVNQRRFVTFSQGPTPLHLAAQACSLE 513
+++ + + H+AA + I+ L VN + G TPLHLAAQ
Sbjct: 563 VSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTL----DGRTPLHLAAQRGHYR 618
Query: 514 TTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLL 573
L+ +D + P+H AA + L + EA + T L
Sbjct: 619 VARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAG---KEAMTSDGYTALH 675
Query: 574 LAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIPEL 628
LAA +G L T++ L A+ +HL+ H+EV++ ++ ++ +L
Sbjct: 676 LAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDL 730
>gi|6912678 sperm associated antigen 6 isoform 1 [Homo sapiens]
Length = 509
Score = 65.1 bits (157), Expect = 4e-10
Identities = 54/236 (22%), Positives = 113/236 (47%), Gaps = 6/236 (2%)
Query: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
LV +Q + +A +L I + + + ++DAG + L ++ + KL+ + +
Sbjct: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILS 231
Query: 694 LLSNISTHK-SAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC--ENKDVIAK 750
LS +S H +VEA P ++ L + V + ++ +IA+ E ++
Sbjct: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
Query: 751 YNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD-SDV 809
G+ ++I+ + N + + + + +EN AV KG+P L LS + D
Sbjct: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
Query: 810 LKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQIS--VQMKGAMAVESL 863
+KA ++ A+ ++GR E A+A+ +P L++L+ + S +Q+K A++++
Sbjct: 352 IKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNI 407
Score = 60.8 bits (146), Expect = 8e-09
Identities = 68/358 (18%), Positives = 148/358 (41%), Gaps = 13/358 (3%)
Query: 686 KLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENK 745
K + + V +++ ++T + L AG + L LL+ P + A+ L +A +
Sbjct: 15 KARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDD 74
Query: 746 --DVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQ--RAVREHKGLPYLIR 801
+ + K + +P L+ +L +N + +G + Q +A+ + L L+
Sbjct: 75 LAEAVVKCDILPQLV--YSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVI 132
Query: 802 FLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVE 861
L +K ++ A+ + R N E+ A+ GA+P LV + +I+++ A A+
Sbjct: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
Query: 862 SLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIG 921
+A H+ + + ++ +L +++ +K Q AL ++ ++ + + E
Sbjct: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
Query: 922 YSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIAEGTL 981
+ ++ L ++ + ++K + + G+A ++ I + T
Sbjct: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDC--IGSCKGNTR 310
Query: 982 LSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACI 1039
L I +G + AH+ N V+ P L L P +IK A++L I
Sbjct: 311 LPGIMMLGYV---AAHSEN--LAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQI 363
>gi|27262641 sperm associated antigen 6 isoform 2 [Homo sapiens]
Length = 458
Score = 65.1 bits (157), Expect = 4e-10
Identities = 54/236 (22%), Positives = 113/236 (47%), Gaps = 6/236 (2%)
Query: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
LV +Q + +A +L I + + + ++DAG + L ++ + KL+ + +
Sbjct: 172 LVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILS 231
Query: 694 LLSNISTHK-SAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC--ENKDVIAK 750
LS +S H +VEA P ++ L + V + ++ +IA+ E ++
Sbjct: 232 ALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVN 291
Query: 751 YNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD-SDV 809
G+ ++I+ + N + + + + +EN AV KG+P L LS + D
Sbjct: 292 AGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQLSVCLSEEPEDH 351
Query: 810 LKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQIS--VQMKGAMAVESL 863
+KA ++ A+ ++GR E A+A+ +P L++L+ + S +Q+K A++++
Sbjct: 352 IKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSKKAIKNI 407
Score = 60.8 bits (146), Expect = 8e-09
Identities = 68/358 (18%), Positives = 148/358 (41%), Gaps = 13/358 (3%)
Query: 686 KLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENK 745
K + + V +++ ++T + L AG + L LL+ P + A+ L +A +
Sbjct: 15 KARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDD 74
Query: 746 --DVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQ--RAVREHKGLPYLIR 801
+ + K + +P L+ +L +N + +G + Q +A+ + L L+
Sbjct: 75 LAEAVVKCDILPQLV--YSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVI 132
Query: 802 FLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVE 861
L +K ++ A+ + R N E+ A+ GA+P LV + +I+++ A A+
Sbjct: 133 CLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALS 192
Query: 862 SLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIG 921
+A H+ + + ++ +L +++ +K Q AL ++ ++ + + E
Sbjct: 193 DIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEI 252
Query: 922 YSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRISTIAEGTL 981
+ ++ L ++ + ++K + + G+A ++ I + T
Sbjct: 253 FPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDC--IGSCKGNTR 310
Query: 982 LSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEVAFSLACI 1039
L I +G + AH+ N V+ P L L P +IK A++L I
Sbjct: 311 LPGIMMLGYV---AAHSEN--LAMAVIISKGVPQLSVCLSEEPEDHIKAAAAWALGQI 363
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 62.0 bits (149), Expect = 4e-09
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N+V + L N QG TPLHLAAQ E LL
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV----QGVTPLHLAAQEGHAEMVALLLSK 690
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A+ L K G P+H A +V + L + + +AT TPL +A+ G +
Sbjct: 691 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG---VMVDATTRMGYTPLHVASHYGNI 747
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+++L A+ G + +H + HT+++ ++K
Sbjct: 748 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 788
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ + +N + T H AA +++ L N N + + G TPLH+AA+
Sbjct: 492 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN----LATTAGHTPLHIAAREG 547
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCT 570
+ET + LL +A K+G+ P+H AA Y V + L +D A +N T
Sbjct: 548 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLT 604
Query: 571 PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
PL +A LD ++ L G + G +H++ EV + +++
Sbjct: 605 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656
Score = 55.8 bits (133), Expect = 3e-07
Identities = 44/166 (26%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N++ AG+T H AA V + L K + +T +G TPLH+AA+ +
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLE---KEASQACMT-KKGFTPLHVAAKYGKVRVA 585
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL A + K G P+H A ++N+ I+ L + S + A N TPL +A
Sbjct: 586 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWNGYTPLHIA 642
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
A ++ + L G + ++G +HL+ H E++ ++
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Score = 53.9 bits (128), Expect = 1e-06
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
TPLH+AA LL A G+ P+H A ++V ++ L + S+
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-- 430
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TPL +A+ G L ++ L GA+ +++K +H++ HTEV KY+
Sbjct: 431 -DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489
Query: 621 IK 622
++
Sbjct: 490 LQ 491
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
NV+ E G+T A +++ L N K R LH+AA+ T
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRTA 222
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL + + + K G+ P+H AA Y+N+ + L + S+ T +N TPL +A
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGITPLHIA 279
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIP 626
+ G + ++ L GA +H + H + + ++ P
Sbjct: 280 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 330
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/170 (24%), Positives = 72/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
+++N + + G T H A+ V ++ L + ++ + TPLH AA+ +
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT----KDELTPLHCAARNGHV 318
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ LL A K G PIH AA D++ + L + D E + + TPL
Sbjct: 319 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHLTPL 375
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+AA G + L GA + G +H++ H V++ ++K
Sbjct: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 425
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/153 (25%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H+RV+ + L + K N R G TPLH+A + + LL + A +
Sbjct: 383 HHRVAKV--LLDKGAKPNSRAL----NGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 436
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G P+H A+F ++ I+ L ++ S + E TPL +AA +G + +YL
Sbjct: 437 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNK 493
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLN 624
A +H + HT ++K +++ N
Sbjct: 494 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 526
Score = 45.1 bits (105), Expect = 5e-04
Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 11/160 (6%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ ++I+ E+G T H A+ + I+ L N V+ + TPLH+AA+A
Sbjct: 426 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN----VSNVKVETPLHMAARAG 481
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAA--FYDNVCIIIALCRKDPSLLEAEATAENQ 568
E LL +KA K P+H AA + N+ ++ +P+L AT
Sbjct: 482 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL----ATTAGH 537
Query: 569 CTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLS 608
TPL +AA G ++T+ L A+ KG +H++
Sbjct: 538 -TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/132 (26%), Positives = 56/132 (42%), Gaps = 7/132 (5%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N+ +++G T H A V + L V+ T G TPLH+A+ +++
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD----ATTRMGYTPLHVASHYGNIKLV 750
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL +AD K G+ P+H AA + I+ L + S E + + TPL +A
Sbjct: 751 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE---VSSDGTTPLAIA 807
Query: 576 ATSGALDTIQYL 587
G + L
Sbjct: 808 KRLGYISVTDVL 819
Score = 42.0 bits (97), Expect = 0.004
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 506 AAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATA 565
AA++ +L+ + L + D + G +H A+ +V +++ L K+ L E T
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIIL---ETTT 108
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ T L +AA +G + ++ L + GAN KG ++++ H EV+K++++
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 165
Score = 37.7 bits (86), Expect = 0.076
Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 22/165 (13%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H R + CN N G LHLA++ ++ V LL + + K+
Sbjct: 64 HLRNGVDINTCNQN-------------GLNGLHLASKEGHVKMVVELLHKEIILETTTKK 110
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G +H AA ++ L ++ A ++ TPL +AA L+ +++L G
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANV---NAQSQKGFTPLYMAAQENHLEVVKFLLENG 167
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYII------KLNIPELPV 630
AN G + +++ H V+ ++I K+ +P L +
Sbjct: 168 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 212
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 62.0 bits (149), Expect = 4e-09
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N+V + L N QG TPLHLAAQ E LL
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV----QGVTPLHLAAQEGHAEMVALLLSK 657
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A+ L K G P+H A +V + L + + +AT TPL +A+ G +
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG---VMVDATTRMGYTPLHVASHYGNI 714
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+++L A+ G + +H + HT+++ ++K
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ + +N + T H AA +++ L N N + + G TPLH+AA+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN----LATTAGHTPLHIAAREG 514
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCT 570
+ET + LL +A K+G+ P+H AA Y V + L +D A +N T
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLT 571
Query: 571 PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
PL +A LD ++ L G + G +H++ EV + +++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 55.8 bits (133), Expect = 3e-07
Identities = 44/166 (26%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N++ AG+T H AA V + L K + +T +G TPLH+AA+ +
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLE---KEASQACMT-KKGFTPLHVAAKYGKVRVA 552
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL A + K G P+H A ++N+ I+ L + S + A N TPL +A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWNGYTPLHIA 609
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
A ++ + L G + ++G +HL+ H E++ ++
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 53.9 bits (128), Expect = 1e-06
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
TPLH+AA LL A G+ P+H A ++V ++ L + S+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-- 397
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TPL +A+ G L ++ L GA+ +++K +H++ HTEV KY+
Sbjct: 398 -DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 621 IK 622
++
Sbjct: 457 LQ 458
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
NV+ E G+T A +++ L N K R LH+AA+ T
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRTA 189
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL + + + K G+ P+H AA Y+N+ + L + S+ T +N TPL +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGITPLHIA 246
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIP 626
+ G + ++ L GA +H + H + + ++ P
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/170 (24%), Positives = 72/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
+++N + + G T H A+ V ++ L + ++ + TPLH AA+ +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT----KDELTPLHCAARNGHV 285
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ LL A K G PIH AA D++ + L + D E + + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHLTPL 342
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+AA G + L GA + G +H++ H V++ ++K
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/153 (25%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H+RV+ + L + K N R G TPLH+A + + LL + A +
Sbjct: 350 HHRVAKV--LLDKGAKPNSRAL----NGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G P+H A+F ++ I+ L ++ S + E TPL +AA +G + +YL
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNK 460
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLN 624
A +H + HT ++K +++ N
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 45.1 bits (105), Expect = 5e-04
Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 11/160 (6%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ ++I+ E+G T H A+ + I+ L N V+ + TPLH+AA+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN----VSNVKVETPLHMAARAG 448
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAA--FYDNVCIIIALCRKDPSLLEAEATAENQ 568
E LL +KA K P+H AA + N+ ++ +P+L AT
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL----ATTAGH 504
Query: 569 CTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLS 608
TPL +AA G ++T+ L A+ KG +H++
Sbjct: 505 -TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/132 (26%), Positives = 56/132 (42%), Gaps = 7/132 (5%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N+ +++G T H A V + L V+ T G TPLH+A+ +++
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD----ATTRMGYTPLHVASHYGNIKLV 717
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL +AD K G+ P+H AA + I+ L + S E + + TPL +A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE---VSSDGTTPLAIA 774
Query: 576 ATSGALDTIQYL 587
G + L
Sbjct: 775 KRLGYISVTDVL 786
Score = 42.0 bits (97), Expect = 0.004
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 506 AAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATA 565
AA++ +L+ + L + D + G +H A+ +V +++ L K+ L E T
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIIL---ETTT 75
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ T L +AA +G + ++ L + GAN KG ++++ H EV+K++++
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 37.7 bits (86), Expect = 0.076
Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 22/165 (13%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H R + CN N G LHLA++ ++ V LL + + K+
Sbjct: 31 HLRNGVDINTCNQN-------------GLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G +H AA ++ L ++ A ++ TPL +AA L+ +++L G
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANV---NAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYII------KLNIPELPV 630
AN G + +++ H V+ ++I K+ +P L +
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 62.0 bits (149), Expect = 4e-09
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N+V + L N QG TPLHLAAQ E LL
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV----QGVTPLHLAAQEGHAEMVALLLSK 657
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A+ L K G P+H A +V + L + + +AT TPL +A+ G +
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG---VMVDATTRMGYTPLHVASHYGNI 714
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+++L A+ G + +H + HT+++ ++K
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ + +N + T H AA +++ L N N + + G TPLH+AA+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN----LATTAGHTPLHIAAREG 514
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCT 570
+ET + LL +A K+G+ P+H AA Y V + L +D A +N T
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLT 571
Query: 571 PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
PL +A LD ++ L G + G +H++ EV + +++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 55.8 bits (133), Expect = 3e-07
Identities = 44/166 (26%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N++ AG+T H AA V + L K + +T +G TPLH+AA+ +
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLE---KEASQACMT-KKGFTPLHVAAKYGKVRVA 552
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL A + K G P+H A ++N+ I+ L + S + A N TPL +A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWNGYTPLHIA 609
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
A ++ + L G + ++G +HL+ H E++ ++
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 53.9 bits (128), Expect = 1e-06
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
TPLH+AA LL A G+ P+H A ++V ++ L + S+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-- 397
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TPL +A+ G L ++ L GA+ +++K +H++ HTEV KY+
Sbjct: 398 -DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 621 IK 622
++
Sbjct: 457 LQ 458
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
NV+ E G+T A +++ L N K R LH+AA+ T
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRTA 189
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL + + + K G+ P+H AA Y+N+ + L + S+ T +N TPL +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGITPLHIA 246
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIP 626
+ G + ++ L GA +H + H + + ++ P
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/170 (24%), Positives = 72/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
+++N + + G T H A+ V ++ L + ++ + TPLH AA+ +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT----KDELTPLHCAARNGHV 285
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ LL A K G PIH AA D++ + L + D E + + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHLTPL 342
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+AA G + L GA + G +H++ H V++ ++K
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/153 (25%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H+RV+ + L + K N R G TPLH+A + + LL + A +
Sbjct: 350 HHRVAKV--LLDKGAKPNSRAL----NGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G P+H A+F ++ I+ L ++ S + E TPL +AA +G + +YL
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNK 460
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLN 624
A +H + HT ++K +++ N
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 45.1 bits (105), Expect = 5e-04
Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 11/160 (6%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ ++I+ E+G T H A+ + I+ L N V+ + TPLH+AA+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN----VSNVKVETPLHMAARAG 448
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAA--FYDNVCIIIALCRKDPSLLEAEATAENQ 568
E LL +KA K P+H AA + N+ ++ +P+L AT
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL----ATTAGH 504
Query: 569 CTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLS 608
TPL +AA G ++T+ L A+ KG +H++
Sbjct: 505 -TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/132 (26%), Positives = 56/132 (42%), Gaps = 7/132 (5%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N+ +++G T H A V + L V+ T G TPLH+A+ +++
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD----ATTRMGYTPLHVASHYGNIKLV 717
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL +AD K G+ P+H AA + I+ L + S E + + TPL +A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE---VSSDGTTPLAIA 774
Query: 576 ATSGALDTIQYL 587
G + L
Sbjct: 775 KRLGYISVTDVL 786
Score = 42.0 bits (97), Expect = 0.004
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 506 AAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATA 565
AA++ +L+ + L + D + G +H A+ +V +++ L K+ L E T
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIIL---ETTT 75
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ T L +AA +G + ++ L + GAN KG ++++ H EV+K++++
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 37.7 bits (86), Expect = 0.076
Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 22/165 (13%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H R + CN N G LHLA++ ++ V LL + + K+
Sbjct: 31 HLRNGVDINTCNQN-------------GLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G +H AA ++ L ++ A ++ TPL +AA L+ +++L G
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANV---NAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYII------KLNIPELPV 630
AN G + +++ H V+ ++I K+ +P L +
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 62.0 bits (149), Expect = 4e-09
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N+V + L N QG TPLHLAAQ E LL
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV----QGVTPLHLAAQEGHAEMVALLLSK 657
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A+ L K G P+H A +V + L + + +AT TPL +A+ G +
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG---VMVDATTRMGYTPLHVASHYGNI 714
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+++L A+ G + +H + HT+++ ++K
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ + +N + T H AA +++ L N N + + G TPLH+AA+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN----LATTAGHTPLHIAAREG 514
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCT 570
+ET + LL +A K+G+ P+H AA Y V + L +D A +N T
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLT 571
Query: 571 PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
PL +A LD ++ L G + G +H++ EV + +++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 55.8 bits (133), Expect = 3e-07
Identities = 44/166 (26%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N++ AG+T H AA V + L K + +T +G TPLH+AA+ +
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLE---KEASQACMT-KKGFTPLHVAAKYGKVRVA 552
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL A + K G P+H A ++N+ I+ L + S + A N TPL +A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWNGYTPLHIA 609
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
A ++ + L G + ++G +HL+ H E++ ++
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 53.9 bits (128), Expect = 1e-06
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
TPLH+AA LL A G+ P+H A ++V ++ L + S+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-- 397
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TPL +A+ G L ++ L GA+ +++K +H++ HTEV KY+
Sbjct: 398 -DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 621 IK 622
++
Sbjct: 457 LQ 458
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
NV+ E G+T A +++ L N K R LH+AA+ T
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRTA 189
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL + + + K G+ P+H AA Y+N+ + L + S+ T +N TPL +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGITPLHIA 246
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIP 626
+ G + ++ L GA +H + H + + ++ P
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/170 (24%), Positives = 72/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
+++N + + G T H A+ V ++ L + ++ + TPLH AA+ +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT----KDELTPLHCAARNGHV 285
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ LL A K G PIH AA D++ + L + D E + + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHLTPL 342
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+AA G + L GA + G +H++ H V++ ++K
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/153 (25%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H+RV+ + L + K N R G TPLH+A + + LL + A +
Sbjct: 350 HHRVAKV--LLDKGAKPNSRAL----NGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G P+H A+F ++ I+ L ++ S + E TPL +AA +G + +YL
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNK 460
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLN 624
A +H + HT ++K +++ N
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 45.1 bits (105), Expect = 5e-04
Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 11/160 (6%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ ++I+ E+G T H A+ + I+ L N V+ + TPLH+AA+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN----VSNVKVETPLHMAARAG 448
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAA--FYDNVCIIIALCRKDPSLLEAEATAENQ 568
E LL +KA K P+H AA + N+ ++ +P+L AT
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL----ATTAGH 504
Query: 569 CTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLS 608
TPL +AA G ++T+ L A+ KG +H++
Sbjct: 505 -TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/132 (26%), Positives = 56/132 (42%), Gaps = 7/132 (5%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N+ +++G T H A V + L V+ T G TPLH+A+ +++
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD----ATTRMGYTPLHVASHYGNIKLV 717
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL +AD K G+ P+H AA + I+ L + S E + + TPL +A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE---VSSDGTTPLAIA 774
Query: 576 ATSGALDTIQYL 587
G + L
Sbjct: 775 KRLGYISVTDVL 786
Score = 42.0 bits (97), Expect = 0.004
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 506 AAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATA 565
AA++ +L+ + L + D + G +H A+ +V +++ L K+ L E T
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIIL---ETTT 75
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ T L +AA +G + ++ L + GAN KG ++++ H EV+K++++
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 37.7 bits (86), Expect = 0.076
Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 22/165 (13%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H R + CN N G LHLA++ ++ V LL + + K+
Sbjct: 31 HLRNGVDINTCNQN-------------GLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G +H AA ++ L ++ A ++ TPL +AA L+ +++L G
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANV---NAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYII------KLNIPELPV 630
AN G + +++ H V+ ++I K+ +P L +
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 62.0 bits (149), Expect = 4e-09
Identities = 46/161 (28%), Positives = 71/161 (44%), Gaps = 7/161 (4%)
Query: 462 GYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCS 521
GYT H AA N+V + L N QG TPLHLAAQ E LL
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESV----QGVTPLHLAAQEGHAEMVALLLSK 657
Query: 522 KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
+A+ L K G P+H A +V + L + + +AT TPL +A+ G +
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG---VMVDATTRMGYTPLHVASHYGNI 714
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+++L A+ G + +H + HT+++ ++K
Sbjct: 715 KLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLK 755
Score = 60.1 bits (144), Expect = 1e-08
Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 7/172 (4%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ + +N + T H AA +++ L N N + + G TPLH+AA+
Sbjct: 459 NKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN----LATTAGHTPLHIAAREG 514
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCT 570
+ET + LL +A K+G+ P+H AA Y V + L +D A +N T
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD---AHPNAAGKNGLT 571
Query: 571 PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
PL +A LD ++ L G + G +H++ EV + +++
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Score = 55.8 bits (133), Expect = 3e-07
Identities = 44/166 (26%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N++ AG+T H AA V + L K + +T +G TPLH+AA+ +
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLE---KEASQACMT-KKGFTPLHVAAKYGKVRVA 552
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL A + K G P+H A ++N+ I+ L + S + A N TPL +A
Sbjct: 553 ELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWNGYTPLHIA 609
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
A ++ + L G + ++G +HL+ H E++ ++
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Score = 53.9 bits (128), Expect = 1e-06
Identities = 35/122 (28%), Positives = 60/122 (49%), Gaps = 3/122 (2%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLE 560
TPLH+AA LL A G+ P+H A ++V ++ L + S+
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASI-- 397
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
+A E+ TPL +A+ G L ++ L GA+ +++K +H++ HTEV KY+
Sbjct: 398 -DAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456
Query: 621 IK 622
++
Sbjct: 457 LQ 458
Score = 48.5 bits (114), Expect = 4e-05
Identities = 40/171 (23%), Positives = 69/171 (40%), Gaps = 11/171 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
NV+ E G+T A +++ L N K R LH+AA+ T
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRL--------PALHIAARNDDTRTA 189
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL + + + K G+ P+H AA Y+N+ + L + S+ T +N TPL +A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASV---NFTPQNGITPLHIA 246
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIP 626
+ G + ++ L GA +H + H + + ++ P
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAP 297
Score = 48.1 bits (113), Expect = 6e-05
Identities = 41/170 (24%), Positives = 72/170 (42%), Gaps = 7/170 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
+++N + + G T H A+ V ++ L + ++ + TPLH AA+ +
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKT----KDELTPLHCAARNGHV 285
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ LL A K G PIH AA D++ + L + D E + + TPL
Sbjct: 286 RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD---AEIDDITLDHLTPL 342
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+AA G + L GA + G +H++ H V++ ++K
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLK 392
Score = 45.4 bits (106), Expect = 4e-04
Identities = 39/153 (25%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H+RV+ + L + K N R G TPLH+A + + LL + A +
Sbjct: 350 HHRVAKV--LLDKGAKPNSRAL----NGFTPLHIACKKNHVRVMELLLKTGASIDAVTES 403
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G P+H A+F ++ I+ L ++ S + E TPL +AA +G + +YL
Sbjct: 404 GLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE---TPLHMAARAGHTEVAKYLLQNK 460
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLN 624
A +H + HT ++K +++ N
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 45.1 bits (105), Expect = 5e-04
Identities = 44/160 (27%), Positives = 72/160 (45%), Gaps = 11/160 (6%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQAC 510
+ ++I+ E+G T H A+ + I+ L N V+ + TPLH+AA+A
Sbjct: 393 TGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN----VSNVKVETPLHMAARAG 448
Query: 511 SLETTVCLLCSKADYTLSEKRGWMPIHFAA--FYDNVCIIIALCRKDPSLLEAEATAENQ 568
E LL +KA K P+H AA + N+ ++ +P+L AT
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL----ATTAGH 504
Query: 569 CTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLS 608
TPL +AA G ++T+ L A+ KG +H++
Sbjct: 505 -TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 43.1 bits (100), Expect = 0.002
Identities = 35/132 (26%), Positives = 56/132 (42%), Gaps = 7/132 (5%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N+ +++G T H A V + L V+ T G TPLH+A+ +++
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVD----ATTRMGYTPLHVASHYGNIKLV 717
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
LL +AD K G+ P+H AA + I+ L + S E + + TPL +A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNE---VSSDGTTPLAIA 774
Query: 576 ATSGALDTIQYL 587
G + L
Sbjct: 775 KRLGYISVTDVL 786
Score = 42.0 bits (97), Expect = 0.004
Identities = 29/117 (24%), Positives = 59/117 (50%), Gaps = 3/117 (2%)
Query: 506 AAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATA 565
AA++ +L+ + L + D + G +H A+ +V +++ L K+ L E T
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIIL---ETTT 75
Query: 566 ENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ T L +AA +G + ++ L + GAN KG ++++ H EV+K++++
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLE 132
Score = 37.7 bits (86), Expect = 0.076
Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 22/165 (13%)
Query: 472 HNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR 531
H R + CN N G LHLA++ ++ V LL + + K+
Sbjct: 31 HLRNGVDINTCNQN-------------GLNGLHLASKEGHVKMVVELLHKEIILETTTKK 77
Query: 532 GWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIG 591
G +H AA ++ L ++ A ++ TPL +AA L+ +++L G
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANV---NAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 592 ANWRKTDIKGNNIIHLSVLTFHTEVLKYII------KLNIPELPV 630
AN G + +++ H V+ ++I K+ +P L +
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHI 179
>gi|224589129 karyopherin 7 [Homo sapiens]
Length = 516
Score = 61.6 bits (148), Expect = 5e-09
Identities = 77/317 (24%), Positives = 134/317 (42%), Gaps = 14/317 (4%)
Query: 665 RCILDAGTIPALINLLKSSKIK-LQCKTVGLLSNISTHKS-AVHALVEAGGIPSLINLLV 722
+ +++AG IP ++ LKSS LQ + L+NI++ S A+VE G I LI LL
Sbjct: 107 KLVIEAGLIPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLS 166
Query: 723 CDEPEVHSRCAVILYDIA--QCENKDVIAKYNGIPSLINLLNLNIE-NVLVNVMNCIRVL 779
V + L +IA E +D + N IP L+ L++ + L N+ + L
Sbjct: 167 SSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNITWTLSNL 226
Query: 780 CIGNENNQRAVREHKGLPYLIRFLS-SDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAI 838
C + LP L+ L DS+VL A NK I + G +
Sbjct: 227 CRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRI-GQVVNTGVL 285
Query: 839 PPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTKYLLKLLKAFQIDVKEQG 898
P LV L +++V V ++ + + ++ + L +LL+ + ++++
Sbjct: 286 PRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEA 345
Query: 899 AVALWALAGQTLKQQKYMAEQIGYSF---IINMLLSPSAKMQYVGGEAVIALSKDSRMHQ 955
A WAL+ ++ + + Y ++ +L + K+Q V + + M Q
Sbjct: 346 A---WALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVWMVANFATGATMDQ 402
Query: 956 -NQICEGNGIAPLVRLL 971
Q+ + PLV LL
Sbjct: 403 LIQLVHSGVLEPLVNLL 419
Score = 45.8 bits (107), Expect = 3e-04
Identities = 56/250 (22%), Positives = 101/250 (40%), Gaps = 12/250 (4%)
Query: 796 LPYLIRFLSSDS-DVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQM 854
+P ++ FL S L+ ++ A+ + E A+ GAI PL+ L ++V
Sbjct: 115 IPRMVEFLKSSLYPCLQFEAAWALTNIASGTSEQTRAVVEGGAIQPLIELLSSSNVAVCE 174
Query: 855 KGAMAVESLASHNALIQKAFLEKSLTKYLLKLLK-AFQIDVKEQGAVALWALAGQTLKQQ 913
+ A+ ++A + + + +LL L+ I W L+ +
Sbjct: 175 QAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRN---ITWTLSNLCRNKN 231
Query: 914 KYMAEQIGYSFIINMLLSPSAKMQYVGGEAVIALSKDSRMHQNQICEGNGIAPLVRLLRI 973
Y + + +L + V +A ALS + +I + L RL+ +
Sbjct: 232 PYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVVNTGVLPRLVVL 291
Query: 974 STIAE-GTLLSVIRAVGSICIGVAHTSNPVSQQFVVDENAFPVLIQLLRNHPSPNIKVEV 1032
T +E L +R VG+I G + Q +D VL QLL+ H P+I+ E
Sbjct: 292 MTSSELNVLTPSLRTVGNIVTGTDEQT-----QMAIDAGMLNVLPQLLQ-HNKPSIQKEA 345
Query: 1033 AFSLACIVLG 1042
A++L+ + G
Sbjct: 346 AWALSNVAAG 355
Score = 45.4 bits (106), Expect = 4e-04
Identities = 60/267 (22%), Positives = 113/267 (42%), Gaps = 7/267 (2%)
Query: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSS-KIKLQCKTV 692
L+E+L + AV +L I ++ ++ + IP L+ L+ + I
Sbjct: 161 LIELLSSSNVAVCEQAVWALGNIAGDGPEFRDNVITSNAIPHLLALISPTLPITFLRNIT 220
Query: 693 GLLSNISTHKSAVHALVEAGGI-PSLINLLVCDEPEVHSRCAVILYDIAQCENKDV--IA 749
LSN+ +K+ I P+L++LL + EV S L + NK + +
Sbjct: 221 WTLSNLCRNKNPYPCDTAVKQILPALLHLLQHQDSEVLSDACWALSYLTDGSNKRIGQVV 280
Query: 750 KYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDV 809
+P L+ L+ + NVL + + + G + + + L L + L +
Sbjct: 281 NTGVLPRLVVLMTSSELNVLTPSLRTVGNIVTGTDEQTQMAIDAGMLNVLPQLLQHNKPS 340
Query: 810 LKAVSSAAIAEVGRDN-KEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLASHNA 868
++ ++ A++ V IQ +A + +PPLVAL K + VQ + V + A+
Sbjct: 341 IQKEAAWALSNVAAGPCHHIQQLLAYD-VLPPLVALLKNGEFKVQKEAVWMVANFATGAT 399
Query: 869 LIQKAFLEKS-LTKYLLKLLKAFQIDV 894
+ Q L S + + L+ LL A + +
Sbjct: 400 MDQLIQLVHSGVLEPLVNLLTAPDVKI 426
Score = 37.0 bits (84), Expect = 0.13
Identities = 28/111 (25%), Positives = 56/111 (50%), Gaps = 6/111 (5%)
Query: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
L ++LQ + A +L + + + +L +P L+ LLK+ + K+Q + V
Sbjct: 330 LPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVLPPLVALLKNGEFKVQKEAVW 389
Query: 694 LLSNISTHKS--AVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742
+++N +T + + LV +G + L+NLL P+V + +I+ D+ C
Sbjct: 390 MVANFATGATMDQLIQLVHSGVLEPLVNLLTA--PDV--KIVLIILDVISC 436
Score = 35.0 bits (79), Expect = 0.49
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 7/128 (5%)
Query: 656 ICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHK-SAVHALVEAGGI 714
I D+ + +DAG + L LL+ +K +Q + LSN++ + L+ +
Sbjct: 310 IVTGTDEQTQMAIDAGMLNVLPQLLQHNKPSIQKEAAWALSNVAAGPCHHIQQLLAYDVL 369
Query: 715 PSLINLLVCDEPEVHSRCAVILYDIAQCENKDVIAK--YNGI-PSLINLL---NLNIENV 768
P L+ LL E +V ++ + A D + + ++G+ L+NLL ++ I +
Sbjct: 370 PPLVALLKNGEFKVQKEAVWMVANFATGATMDQLIQLVHSGVLEPLVNLLTAPDVKIVLI 429
Query: 769 LVNVMNCI 776
+++V++CI
Sbjct: 430 ILDVISCI 437
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 60.1 bits (144), Expect = 1e-08
Identities = 53/204 (25%), Positives = 79/204 (38%), Gaps = 40/204 (19%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPL--------- 503
S N+ D+ T H AA H S+ LC A VN + +G TPL
Sbjct: 469 SNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKN----REGETPLLTASARGYH 524
Query: 504 ------------------------HLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFA 539
HLA + C +E LL ++ G P+H A
Sbjct: 525 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584
Query: 540 AFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDI 599
N+ I++ALC + +L + + + TPL LAA +G LD ++YL +GA+
Sbjct: 585 CKDGNMPIVVALCEANCNL---DISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTT 641
Query: 600 KGNNIIHLSVLTFHTEVLKYIIKL 623
G L+ H V + +L
Sbjct: 642 DGKTAEDLARSEQHEHVAGLLARL 665
Score = 53.1 bits (126), Expect = 2e-06
Identities = 44/169 (26%), Positives = 73/169 (43%), Gaps = 7/169 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
S I+V D+ G + AA H V + L ++ V G LH+AA+
Sbjct: 403 SRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLD----VKDKSGEMALHVAARYGHA 458
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ L ++ + +K P+H AA++ + ALC ++ E TPL
Sbjct: 459 DVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGE---TPL 515
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
L A+ G D ++ L GA+ D G+ +HL+V EV+K ++
Sbjct: 516 LTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLL 564
Score = 31.2 bits (69), Expect = 7.1
Identities = 16/56 (28%), Positives = 28/56 (50%)
Query: 571 PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIP 626
PLL+AA G + +Q L G+ D G+N ++ + H + LK++ + P
Sbjct: 382 PLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCP 437
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 59.3 bits (142), Expect = 2e-08
Identities = 56/192 (29%), Positives = 82/192 (42%), Gaps = 15/192 (7%)
Query: 434 AVERG-LSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRR 492
AVERG + A+ H S + + D++GY H AA + I C +
Sbjct: 534 AVERGKVRAIQHLLK---SGAVPDALDQSGYGPLHTAAARGKYLI----CKMLLRYGASL 586
Query: 493 FVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIAL- 551
+ QG TPLHLAA LE L S A+ W P+H AA + ++ AL
Sbjct: 587 ELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL 646
Query: 552 -CRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVL 610
C DP+ A ++ TPL LA ++ L AN + G HL+ L
Sbjct: 647 QCGADPN-----AAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAAL 701
Query: 611 TFHTEVLKYIIK 622
+T +LK +++
Sbjct: 702 KGNTAILKVLVE 713
Score = 57.4 bits (137), Expect = 9e-08
Identities = 53/183 (28%), Positives = 76/183 (41%), Gaps = 11/183 (6%)
Query: 456 NVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETT 515
N DE G+ H AA + L + V+ + +G TPLHLAAQ
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQE----REGWTPLHLAAQNNFENVA 477
Query: 516 VCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
L+ +AD L E G P+H AA++ +V ++ L + E +A N TPL LA
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG---AELDAQQRNLRTPLHLA 534
Query: 576 ATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSV----LTFHTEVLKYIIKLNIPELPVW 631
G + IQ+L GA D G +H + +L+Y L +P W
Sbjct: 535 VERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
Query: 632 KTL 634
L
Sbjct: 595 TPL 597
Score = 50.8 bits (120), Expect = 9e-06
Identities = 41/154 (26%), Positives = 59/154 (38%), Gaps = 9/154 (5%)
Query: 434 AVERGLSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRF 493
A +G + H + S + + +T H AA H +++ L N
Sbjct: 600 AAYKGHLEIIHLLAE--SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAE- 656
Query: 494 VTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCR 553
G TPLHLA Q + + + LL A+ K GW P H AA N I+ L
Sbjct: 657 ---QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE 713
Query: 554 KDPSLLEAEATAENQCTPLLLAATSGALDTIQYL 587
L + + CTPL LA S + +L
Sbjct: 714 AGAQLDVQDGVS---CTPLQLALRSRKQGIMSFL 744
Score = 43.5 bits (101), Expect = 0.001
Identities = 40/161 (24%), Positives = 63/161 (39%), Gaps = 40/161 (24%)
Query: 497 SQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAA---------------- 540
+ G TPL +AAQ + LL AD ++ GW P+HFAA
Sbjct: 393 ASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGA 452
Query: 541 -------------------FYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGAL 581
++NV ++ + DP+L EAE TPL +AA G +
Sbjct: 453 CVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGK-----TPLHVAAYFGHV 507
Query: 582 DTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
++ L S GA +HL+V +++++K
Sbjct: 508 SLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLK 548
Score = 31.6 bits (70), Expect = 5.4
Identities = 29/123 (23%), Positives = 50/123 (40%), Gaps = 7/123 (5%)
Query: 501 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAF--YDNVCIIIALCRKDPSL 558
TPLH S+E LL + D G+ P+ AA ++C ++ D +
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 559 LEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLK 618
++ + A PL AA +G T + L GA + +G +HL+ V +
Sbjct: 424 VDEDGWA-----PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVAR 478
Query: 619 YII 621
++
Sbjct: 479 LLV 481
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 59.3 bits (142), Expect = 2e-08
Identities = 53/167 (31%), Positives = 69/167 (41%), Gaps = 7/167 (4%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
+N D T H AA II L + +VN + S+ TPLH A +CS E
Sbjct: 34 VNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD----SKWLTPLHRAVASCSEEA 89
Query: 515 TVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLL 574
LL AD +K P+H AA V AL P L + T L
Sbjct: 90 VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALV---PLLSNVNVSDRAGRTALHH 146
Query: 575 AATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
AA SG + ++ L S GAN D K IH + H EV+K ++
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLV 193
Score = 54.3 bits (129), Expect = 8e-07
Identities = 45/126 (35%), Positives = 60/126 (47%), Gaps = 10/126 (7%)
Query: 499 GPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSL 558
G T LH AA +LE LL + AD+ +K G P+H+AA N + AL S+
Sbjct: 405 GRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASV 464
Query: 559 LEAEATAENQCTPLLLAATSGALDT----IQYLFSIGANWRKTDIKGNNIIHLSVLTFHT 614
+ + E CTPL AATS DT ++YL AN D +G N +H S H
Sbjct: 465 NDLD---ERGCTPLHYAATS---DTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHR 518
Query: 615 EVLKYI 620
L+ I
Sbjct: 519 LCLQLI 524
Score = 52.4 bits (124), Expect = 3e-06
Identities = 46/172 (26%), Positives = 77/172 (44%), Gaps = 11/172 (6%)
Query: 452 SSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACS 511
S+ +N D+ T H AA + V L VN V+ G T LH AA +
Sbjct: 97 SADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN----VSDRAGRTALHHAAFSGH 152
Query: 512 LETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQ--C 569
E LL A+ +K+ IH+AA+ ++ ++ L AE T +++
Sbjct: 153 GEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHG-----AEVTCKDKKSY 207
Query: 570 TPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
TPL AA+SG + ++YL +G + + + GN +H++ V+ +I
Sbjct: 208 TPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELI 259
Score = 49.3 bits (116), Expect = 3e-05
Identities = 45/168 (26%), Positives = 69/168 (41%), Gaps = 8/168 (4%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNAN-FKVNQRRFVTFSQGPTPLHLAAQACSLE 513
+N +E G+T H AA ++ +L N VN + G TPLH+ A
Sbjct: 265 VNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS----KDGKTPLHMTALHGRFS 320
Query: 514 TTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLL 573
+ ++ S A +K G P+H AA Y + +I L S + + PL
Sbjct: 321 RSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI---TSGADTAKRGIHGMFPLH 377
Query: 574 LAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
LAA SG D + L S G + D G +H + + E L ++
Sbjct: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLL 425
Score = 47.8 bits (112), Expect = 7e-05
Identities = 45/153 (29%), Positives = 67/153 (43%), Gaps = 9/153 (5%)
Query: 452 SSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACS 511
+S +N +D G T H AA + V + L + N +VN S G TPL +AA+
Sbjct: 813 ASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNS----VDSTGKTPLMMAAENGQ 868
Query: 512 LETTVCLLCS-KADYTLSEKRGWMPIHFAAFYDNVCIIIALCRK--DPSLLEAEATAENQ 568
T L+ S A+ TL + +H A + + + K D +L+ A A
Sbjct: 869 TNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ- 927
Query: 569 CTPLLLAATSGALDTIQYLFSIGANWRKTDIKG 601
TPL +AA +G +Q L GA+ D G
Sbjct: 928 -TPLHVAARNGLTMVVQELLGKGASVLAVDENG 959
Score = 43.5 bits (101), Expect = 0.001
Identities = 42/185 (22%), Positives = 78/185 (42%), Gaps = 14/185 (7%)
Query: 446 FSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHL 505
+S + ++ D+ G T H A+ + L K R S+G TP+HL
Sbjct: 670 YSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRD----SRGRTPIHL 725
Query: 506 AAQACSLETTVCLLCSKADY----TLSEKRGWMPIHFAAFYDN-VCIIIALCRKDPSLLE 560
+A + LL S A ++ G+ +H+A + + C+ + L ++ E
Sbjct: 726 SAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTE 785
Query: 561 AEATAENQCTPLLLAATSGALDTIQYLFSIGANW-RKTDIKGNNIIHLSVLTFHTEVLKY 619
A + C ++ GA + + + ++GA+ TD KG +H + T H E L+
Sbjct: 786 GNAFSPLHCA--VINDNEGAAEML--IDTLGASIVNATDSKGRTPLHAAAFTDHVECLQL 841
Query: 620 IIKLN 624
++ N
Sbjct: 842 LLSHN 846
Score = 41.6 bits (96), Expect = 0.005
Identities = 49/181 (27%), Positives = 75/181 (41%), Gaps = 18/181 (9%)
Query: 451 SSSTINVSDE---AGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAA 507
+S T +SD A + H AA H + L + ++ R S G TPL LAA
Sbjct: 536 TSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRN----SSGRTPLDLAA 591
Query: 508 QACSLETTVCLLCSKA-----DYTLSEKRGWMPIHFAAFYDNV-CIIIALCRKDPSLLEA 561
+E L+ A DY L PIH AA + C+ + + +P
Sbjct: 592 FKGHVECVDVLINQGASILVKDYILKRT----PIHAAATNGHSECLRLLIGNAEPQNA-V 646
Query: 562 EATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
+ N TPL+L+ +G D + L + GAN D G +H +T H E + ++
Sbjct: 647 DIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALL 706
Query: 622 K 622
+
Sbjct: 707 Q 707
Score = 40.4 bits (93), Expect = 0.012
Identities = 42/181 (23%), Positives = 78/181 (43%), Gaps = 14/181 (7%)
Query: 451 SSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQA- 509
+ + N D+ G + H+AA + + L + VN +G TPLH AA +
Sbjct: 427 TGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD----ERGCTPLHYAATSD 482
Query: 510 CSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDP--SLLEAEAT--- 564
+ LL + A+ + +K+G+ +H++A Y + + + + P L+E T
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
Query: 565 --AENQCT--PLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYI 620
++N+ T PL LAA G ++ L + + G + L+ H E + +
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602
Query: 621 I 621
I
Sbjct: 603 I 603
Score = 40.0 bits (92), Expect = 0.015
Identities = 40/159 (25%), Positives = 69/159 (43%), Gaps = 11/159 (6%)
Query: 458 SDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVC 517
+D GYT H A + + + L +V Q+ T +PLH A +
Sbjct: 752 ADNHGYTALHWACYNGHETCVELLLEQ--EVFQK---TEGNAFSPLHCAVINDNEGAAEM 806
Query: 518 LL--CSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLA 575
L+ + ++ +G P+H AAF D+V + L + + ++T + TPL++A
Sbjct: 807 LIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGK---TPLMMA 863
Query: 576 ATSGALDTIQYLF-SIGANWRKTDIKGNNIIHLSVLTFH 613
A +G +T++ L S A D N +HL+ H
Sbjct: 864 AENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 57.4 bits (137), Expect = 9e-08
Identities = 51/210 (24%), Positives = 84/210 (40%), Gaps = 35/210 (16%)
Query: 450 TSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNAN------------------------ 485
T +N D G++ HHAAL+ +I L A
Sbjct: 37 TKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE 96
Query: 486 -----FKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAA 540
K + +G PLHLAAQ + + LL +++ + + G P+ A
Sbjct: 97 PMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLAC 156
Query: 541 FYDNVCIIIALCRKD--PSLLE---AEATAENQCTPLLLAATSGALDTIQYLFSIGANWR 595
+ V ++ L + +LLE +AT N +PL LAA +G +D I+ L G +
Sbjct: 157 EFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN 216
Query: 596 KTDIKGNNIIHLSVLTFHTEVLKYIIKLNI 625
+ K +H + L TEV++ ++ I
Sbjct: 217 R-QTKSGTALHEAALCGKTEVVRLLLDSGI 245
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 57.4 bits (137), Expect = 9e-08
Identities = 42/161 (26%), Positives = 68/161 (42%), Gaps = 7/161 (4%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
S++NVSD G T HHAAL+ V ++ L +N + LH AA L
Sbjct: 106 SSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN----AFDKKDRRALHWAAYMGHL 161
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPL 572
+ L+ A+ T +K+G+ P+H AA + ++ L + E T L
Sbjct: 162 DVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGN---TAL 218
Query: 573 LLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFH 613
+A +G + L GAN + + G +H + + H
Sbjct: 219 HIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTH 259
Score = 48.9 bits (115), Expect = 3e-05
Identities = 51/202 (25%), Positives = 85/202 (42%), Gaps = 35/202 (17%)
Query: 449 KTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAA- 507
++S + + D+ G T H+AA + I L VN+ T G T LH AA
Sbjct: 400 QSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNE----TDDWGRTALHYAAA 455
Query: 508 ------------------------QACSLETTVC---LLCSKADYTLSEKRGWMPIHFAA 540
+ E T+C LL + A+ ++ +K G+ IH+AA
Sbjct: 456 SDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAA 515
Query: 541 FYDN-VCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDI 599
Y + C+ + L R + E+++ A +PL LAA +G ++ L + D
Sbjct: 516 AYGHRQCLELLLERTNSGFEESDSGATK--SPLHLAAYNGHHQALEVLLQSLVDLDIRDE 573
Query: 600 KGNNIIHLSVLTFHTEVLKYII 621
KG + L+ HTE ++ +I
Sbjct: 574 KGRTALDLAAFKGHTECVEALI 595
Score = 47.0 bits (110), Expect = 1e-04
Identities = 45/168 (26%), Positives = 67/168 (39%), Gaps = 9/168 (5%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
+N D T H AA II L + +VN + + TPLH A + S E
Sbjct: 9 VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWL----TPLHRAVASRSEEA 64
Query: 515 TVCLLCSKADYTLSEKRGWMPIHFAAFYDNV-CIIIALCRKDPSLLEAEATAENQCTPLL 573
L+ AD +K P+H AA V C + + P L + T L
Sbjct: 65 VQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVII----PLLSSVNVSDRGGRTALH 120
Query: 574 LAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 621
AA +G ++ + L + GAN D K +H + H +V+ +I
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLI 168
Score = 47.0 bits (110), Expect = 1e-04
Identities = 48/186 (25%), Positives = 79/186 (42%), Gaps = 15/186 (8%)
Query: 439 LSAVFHTFSRKTSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQ 498
++ V H + INV G T H A + + +++ +L + VNQ +
Sbjct: 194 INVVKHLLNLGVEIDEINVY---GNTALHIACYNGQDAVVNELIDYGANVNQPN----NN 246
Query: 499 GPTPLHLAAQACSLETTVCL---LCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKD 555
G TPLH AA S +CL + + AD + K G P+H A + L +
Sbjct: 247 GFTPLHFAA--ASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNG 304
Query: 556 PSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTE 615
E + ++ TPL +AA G I L + GA+ K I +HL+ L H++
Sbjct: 305 G---EIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSD 361
Query: 616 VLKYII 621
+ ++
Sbjct: 362 CCRKLL 367
Score = 47.0 bits (110), Expect = 1e-04
Identities = 46/207 (22%), Positives = 79/207 (38%), Gaps = 42/207 (20%)
Query: 456 NVSDEAGYTIFHHAALHNR---VSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSL 512
++ D+ GY H+AA + + ++ + N+ F+ + +PLHLAA
Sbjct: 501 SIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDS-----GATKSPLHLAAYNGHH 555
Query: 513 ETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPS--------------- 557
+ LL S D + +++G + AAF + + AL S
Sbjct: 556 QALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHA 615
Query: 558 ------------LLEAEATAE-------NQCTPLLLAATSGALDTIQYLFSIGANWRKTD 598
LLE E TPL+LA G +D + L AN D
Sbjct: 616 SVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVD 675
Query: 599 IKGNNIIHLSVLTFHTEVLKYIIKLNI 625
I G +H ++T H E ++ +++ +
Sbjct: 676 ILGCTALHRGIMTGHEECVQMLLEQEV 702
Score = 40.8 bits (94), Expect = 0.009
Identities = 48/212 (22%), Positives = 80/212 (37%), Gaps = 37/212 (17%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLC-NANFKVNQRRFVTFSQGPTPLHLAAQACS 511
+ +N + G+T H AA ++ +L N VN + G +PLH+ A
Sbjct: 238 ANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVN----IQSKDGKSPLHMTAVHGR 293
Query: 512 LETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIAL-------------------- 551
+ L+ + + +K G P+H AA Y + +I L
Sbjct: 294 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL 353
Query: 552 ---------CRK-DPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKG 601
CRK S E + + T L AA G ++ I+ L S GA++ K D G
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCG 413
Query: 602 NNIIHLSVLTFHTEVLKYIIK--LNIPELPVW 631
+H + H ++ ++ N+ E W
Sbjct: 414 RTPLHYAAANCHFHCIETLVTTGANVNETDDW 445
Score = 40.0 bits (92), Expect = 0.015
Identities = 43/176 (24%), Positives = 69/176 (39%), Gaps = 18/176 (10%)
Query: 450 TSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQA 509
+S I+ D+ G T H AA V I L ++ +++ G TPLH AA
Sbjct: 368 SSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKD----KCGRTPLHYAAAN 423
Query: 510 CSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYD---NVCIIIALCRKDPSLLEAEATAE 566
C L+ + A+ ++ G +H+AA D N I+ L A E
Sbjct: 424 CHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKE 483
Query: 567 NQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
+ T L ++L AN D +G N IH + H + L+ +++
Sbjct: 484 KEATLCL-----------EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 57.4 bits (137), Expect = 9e-08
Identities = 44/135 (32%), Positives = 60/135 (44%), Gaps = 4/135 (2%)
Query: 459 DEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCL 518
D+ G+T H AA+ + S+I L + VN T G TPLHLA Q T+ L
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMVN----ATDYHGATPLHLACQKGYQSVTLLL 515
Query: 519 LCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATS 578
L KA + + G P+H A Y + + AL D + E TPL +AA
Sbjct: 516 LHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARW 575
Query: 579 GALDTIQYLFSIGAN 593
G I+ L GA+
Sbjct: 576 GYQGVIETLLQNGAS 590
Score = 47.4 bits (111), Expect = 1e-04
Identities = 44/206 (21%), Positives = 75/206 (36%), Gaps = 40/206 (19%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
+NV+ + G + H AALH R +I L R + PLHLA Q +
Sbjct: 737 VNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARN----ADQAVPLHLACQQGHFQV 792
Query: 515 TVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLL 574
CLL S A + G TPL+
Sbjct: 793 VKCLLDSNAKPNKKDLSG------------------------------------NTPLIY 816
Query: 575 AATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNIPELPVWKTL 634
A + G + + L GA+ ++ KGN +H +V+ H V++ ++ + K
Sbjct: 817 ACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQ 876
Query: 635 VEMLQCESYKRRMMAVMSLEVICLAN 660
+ C ++M ++ + C+A+
Sbjct: 877 RTAVDCAEQNSKIMELLQVVPSCVAS 902
Score = 35.4 bits (80), Expect = 0.38
Identities = 26/97 (26%), Positives = 40/97 (41%), Gaps = 3/97 (3%)
Query: 529 EKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLF 588
+ RG P+H AA +I L K + AT + TPL LA G L
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGAMV---NATDYHGATPLHLACQKGYQSVTLLLL 516
Query: 589 SIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNI 625
A+ D GN +HL+ H + +K ++ ++
Sbjct: 517 HYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDV 553
Score = 32.3 bits (72), Expect = 3.2
Identities = 22/72 (30%), Positives = 33/72 (45%)
Query: 537 HFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRK 596
H F D+ +++ DPS++ + + TPL +AA G I L S GA
Sbjct: 432 HPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNA 491
Query: 597 TDIKGNNIIHLS 608
TD G +HL+
Sbjct: 492 TDYHGATPLHLA 503
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 57.4 bits (137), Expect = 9e-08
Identities = 53/202 (26%), Positives = 84/202 (41%), Gaps = 38/202 (18%)
Query: 454 TINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQ----- 508
+++V+D G+ H AA HN V + L NA+ N + TF +G LHLAA
Sbjct: 35 SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF-EGFCALHLAASQGHWK 93
Query: 509 -------------ACSLETTVCLLCSKADYTLSEKR----------------GWMPIHFA 539
A +LE T L + + + R GW +H A
Sbjct: 94 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA 153
Query: 540 AFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDI 599
+F +N II L RK + E + TPL +AA G L+++ L S GAN +
Sbjct: 154 SFQENAEIIKLLLRKGAN---KECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQAL 210
Query: 600 KGNNIIHLSVLTFHTEVLKYII 621
+ ++ HT+ ++ ++
Sbjct: 211 DKATPLFIAAQEGHTKCVELLL 232
Score = 47.8 bits (112), Expect = 7e-05
Identities = 40/152 (26%), Positives = 67/152 (44%), Gaps = 34/152 (22%)
Query: 505 LAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPS------- 557
LAA+ +++ LL +++ RGWMPIH AA++++V + L D S
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 558 ----------------------LLEA----EATAENQCTPLLLAATSGALDTIQYLFSIG 591
LLEA AT + TPL LA +G +D ++ L G
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 592 ANWRKT-DIKGNNIIHLSVLTFHTEVLKYIIK 622
AN + + G N +H + + E++K +++
Sbjct: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLR 167
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 57.0 bits (136), Expect = 1e-07
Identities = 76/336 (22%), Positives = 148/336 (44%), Gaps = 23/336 (6%)
Query: 568 QCTPLLLAATSGALDTIQYLFSIG---ANWRKTDIKGNNIIHLSVLTFHTEVL-KYIIKL 623
+CT +L S + + +F G A R +++ ++ T H +L + K+
Sbjct: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262
Query: 624 NIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKS- 682
+ + +V +L + K + L+++ N + IL G AL+ ++++
Sbjct: 263 AVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY 322
Query: 683 SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742
S KL T +L +S S A+VEAGG+ +L L + P + C L +++
Sbjct: 323 SYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-- 380
Query: 743 ENKDVIAKYNGIPS----LINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY 798
DV K G+ S L+N L+++ NVL + L N N+ V ++ G+
Sbjct: 381 ---DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEA 437
Query: 799 LIRFL--SSDSDVLKAVSSAAIAEVGRDNKE---IQDAIAMEGAIPPLVALFKGKQISVQ 853
LI + + D D + + A+ + + E Q+++ + IP +V L
Sbjct: 438 LIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPL 497
Query: 854 MKGAMA-VESLA---SHNALIQKAFLEKSLTKYLLK 885
+K + + +LA +++A +Q+A + L + L+K
Sbjct: 498 VKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVK 533
Score = 54.3 bits (129), Expect = 8e-07
Identities = 61/291 (20%), Positives = 125/291 (42%), Gaps = 16/291 (5%)
Query: 691 TVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCEN--KDVI 748
T +L N+S H+ + A+ ++GGIP+L+ +L V L+++ + K +
Sbjct: 205 TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAV 264
Query: 749 AKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSD 808
+G+ ++ LLN N L +C+++L GN+ ++ + + G L++ + + S
Sbjct: 265 RLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
Query: 809 VLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM--AVESLASH 866
+++ + +V + AI G + L GK ++ + + +L +
Sbjct: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL-----GKHLTSNSPRLVQNCLWTLRNL 379
Query: 867 NALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFII 926
+ + K +S+ K L+ L ++V L L K + + + G +I
Sbjct: 380 SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439
Query: 927 NMLLSPSAKMQYVGGEAVIAL------SKDSRMHQNQICEGNGIAPLVRLL 971
+ +L K + AV AL ++ M QN + GI +V+LL
Sbjct: 440 HAILRAGDK-DDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
Score = 45.8 bits (107), Expect = 3e-04
Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 9/180 (5%)
Query: 673 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVH--- 729
+P L LL + K +++ +S +++ AL+ G P L+ +V
Sbjct: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTSDLD 200
Query: 730 -SRCAV-ILYDIAQC-ENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENN 786
+RC IL++++ E I K GIP+L+ +L+ +E+VL + + L + E
Sbjct: 201 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 260
Query: 787 QRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFK 846
+ AVR GL ++ L+ ++ A+++ + + N+E + I G LV + +
Sbjct: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
Score = 42.0 bits (97), Expect = 0.004
Identities = 43/177 (24%), Positives = 74/177 (41%), Gaps = 22/177 (12%)
Query: 673 IPALINLLKS-SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSR 731
IPA++ LL ++ L T+GL+ N++ + L EA IP L+ LLV +
Sbjct: 482 IPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRH 541
Query: 732 CAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVR 791
A Q D + +E ++ + +L N R
Sbjct: 542 VAAG----TQQPYTD---------------GVRMEEIVEGCTGALHILARDPMNRMEIFR 582
Query: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGK 848
+ +P ++ L S + ++ V++ + E+ +D KE DAI EGA PL+ L +
Sbjct: 583 LNT-IPLFVQLLYSSVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
Score = 35.8 bits (81), Expect = 0.29
Identities = 23/80 (28%), Positives = 36/80 (45%)
Query: 667 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEP 726
I TIP + LL SS +Q G+L ++ K A A+ G L+ LL
Sbjct: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNE 639
Query: 727 EVHSRCAVILYDIAQCENKD 746
+ A +L+ I++ +N D
Sbjct: 640 GTATYAAAVLFRISEDKNPD 659
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 57.0 bits (136), Expect = 1e-07
Identities = 76/336 (22%), Positives = 148/336 (44%), Gaps = 23/336 (6%)
Query: 568 QCTPLLLAATSGALDTIQYLFSIG---ANWRKTDIKGNNIIHLSVLTFHTEVL-KYIIKL 623
+CT +L S + + +F G A R +++ ++ T H +L + K+
Sbjct: 203 RCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKM 262
Query: 624 NIPELPVWKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKS- 682
+ + +V +L + K + L+++ N + IL G AL+ ++++
Sbjct: 263 AVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY 322
Query: 683 SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQC 742
S KL T +L +S S A+VEAGG+ +L L + P + C L +++
Sbjct: 323 SYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQNCLWTLRNLS-- 380
Query: 743 ENKDVIAKYNGIPS----LINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPY 798
DV K G+ S L+N L+++ NVL + L N N+ V ++ G+
Sbjct: 381 ---DVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEA 437
Query: 799 LIRFL--SSDSDVLKAVSSAAIAEVGRDNKE---IQDAIAMEGAIPPLVALFKGKQISVQ 853
LI + + D D + + A+ + + E Q+++ + IP +V L
Sbjct: 438 LIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPL 497
Query: 854 MKGAMA-VESLA---SHNALIQKAFLEKSLTKYLLK 885
+K + + +LA +++A +Q+A + L + L+K
Sbjct: 498 VKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVK 533
Score = 54.3 bits (129), Expect = 8e-07
Identities = 61/291 (20%), Positives = 125/291 (42%), Gaps = 16/291 (5%)
Query: 691 TVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCEN--KDVI 748
T +L N+S H+ + A+ ++GGIP+L+ +L V L+++ + K +
Sbjct: 205 TTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGAKMAV 264
Query: 749 AKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSD 808
+G+ ++ LLN N L +C+++L GN+ ++ + + G L++ + + S
Sbjct: 265 RLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNYSY 324
Query: 809 VLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAM--AVESLASH 866
+++ + +V + AI G + L GK ++ + + +L +
Sbjct: 325 EKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQAL-----GKHLTSNSPRLVQNCLWTLRNL 379
Query: 867 NALIQKAFLEKSLTKYLLKLLKAFQIDVKEQGAVALWALAGQTLKQQKYMAEQIGYSFII 926
+ + K +S+ K L+ L ++V L L K + + + G +I
Sbjct: 380 SDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALI 439
Query: 927 NMLLSPSAKMQYVGGEAVIAL------SKDSRMHQNQICEGNGIAPLVRLL 971
+ +L K + AV AL ++ M QN + GI +V+LL
Sbjct: 440 HAILRAGDK-DDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLL 489
Score = 45.8 bits (107), Expect = 3e-04
Identities = 42/180 (23%), Positives = 83/180 (46%), Gaps = 9/180 (5%)
Query: 673 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVH--- 729
+P L LL + K +++ +S +++ AL+ G P L+ +V
Sbjct: 144 LPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM---GSPQLVAAVVRTMQNTSDLD 200
Query: 730 -SRCAV-ILYDIAQC-ENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENN 786
+RC IL++++ E I K GIP+L+ +L+ +E+VL + + L + E
Sbjct: 201 TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQEGA 260
Query: 787 QRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFK 846
+ AVR GL ++ L+ ++ A+++ + + N+E + I G LV + +
Sbjct: 261 KMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMR 320
Score = 42.0 bits (97), Expect = 0.004
Identities = 43/177 (24%), Positives = 74/177 (41%), Gaps = 22/177 (12%)
Query: 673 IPALINLLKS-SKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSR 731
IPA++ LL ++ L T+GL+ N++ + L EA IP L+ LLV +
Sbjct: 482 IPAIVKLLNQPNQWPLVKATIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRH 541
Query: 732 CAVILYDIAQCENKDVIAKYNGIPSLINLLNLNIENVLVNVMNCIRVLCIGNENNQRAVR 791
A Q D + +E ++ + +L N R
Sbjct: 542 VAAG----TQQPYTD---------------GVRMEEIVEGCTGALHILARDPMNRMEIFR 582
Query: 792 EHKGLPYLIRFLSSDSDVLKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGK 848
+ +P ++ L S + ++ V++ + E+ +D KE DAI EGA PL+ L +
Sbjct: 583 LNT-IPLFVQLLYSSVENIQRVAAGVLCELAQD-KEAADAIDAEGASAPLMELLHSR 637
Score = 35.8 bits (81), Expect = 0.29
Identities = 23/80 (28%), Positives = 36/80 (45%)
Query: 667 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEP 726
I TIP + LL SS +Q G+L ++ K A A+ G L+ LL
Sbjct: 580 IFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEGASAPLMELLHSRNE 639
Query: 727 EVHSRCAVILYDIAQCENKD 746
+ A +L+ I++ +N D
Sbjct: 640 GTATYAAAVLFRISEDKNPD 659
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/173 (25%), Positives = 78/173 (45%), Gaps = 14/173 (8%)
Query: 455 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQACSLET 514
+N +D +GYT HHAAL+ I+ +L N V ++G P+HLAA +E
Sbjct: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTN----VADNKGYFPIHLAAWKGDVEI 107
Query: 515 TVCLL---CSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRK--DPSLLEAEATAENQC 569
L+ S + +H AA Y + ++ L + DP++ ++
Sbjct: 108 VKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE----- 162
Query: 570 TPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
TPL LAA G L ++ + S N + + + +HL+ H V++ +++
Sbjct: 163 TPLDLAALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVLLE 215
Score = 53.5 bits (127), Expect = 1e-06
Identities = 46/176 (26%), Positives = 80/176 (45%), Gaps = 11/176 (6%)
Query: 453 STINVSDEAGYTIFHHAALHNRVSIICQLCN---ANFKVNQRRFVTFSQGPTPLHLAAQA 509
++ NV+D GY H AA V I+ L + ++ +VN++ ++ T LH AAQ
Sbjct: 83 ASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQN----NENETALHCAAQY 138
Query: 510 CSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQC 569
E LL D T+ + P+ AA Y + ++ + P+L+ +
Sbjct: 139 GHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPNLMSCNT---RKH 195
Query: 570 TPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIKLNI 625
TPL LAA +G +Q L G + KG + +H + L +V++ +++ I
Sbjct: 196 TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKG-SALHEAALFGKVDVVRVLLETGI 250
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/215 (26%), Positives = 88/215 (40%), Gaps = 19/215 (8%)
Query: 450 TSSSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFVTFSQGPTPLHLAAQA 509
T +N D G++ HHAAL + +I L A V+ + S G PLH AA
Sbjct: 37 TKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVD----IKDSNGMRPLHYAAWQ 92
Query: 510 CSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDN--VCIIIALCRKDPSLLEAEATAEN 567
LE LL + A + G +P+H AA Y + V ++ + +P L+ +
Sbjct: 93 GRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN-----KA 147
Query: 568 QCTPLLLAATSGALDTIQYLFSI--------GANWRKTDIKGNNIIHLSVLTFHTEVLKY 619
+ TPL LA G L Q L + G D +HL+ H EV++
Sbjct: 148 KKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQ 207
Query: 620 IIKLNIPELPVWKTLVEMLQCESYKRRMMAVMSLE 654
+++ I KT + + Y + + + LE
Sbjct: 208 LLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLE 242
>gi|4504897 karyopherin alpha 2 [Homo sapiens]
Length = 529
Score = 55.1 bits (131), Expect = 5e-07
Identities = 67/307 (21%), Positives = 129/307 (42%), Gaps = 19/307 (6%)
Query: 652 SLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALV-E 710
+L I + + ++D G IPA I+LL S + + V L NI+ S LV +
Sbjct: 143 ALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIK 202
Query: 711 AGGIPSLINLLVCDEPEVHSRCAVILYDIA-----QCENKD----VIAKYNGIPSLINLL 761
G + L+ LL P++ S L ++ C NK+ + A +P+L+ LL
Sbjct: 203 YGAVDPLLALLAV--PDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLL 260
Query: 762 NLNIENVLVNVMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSDSDVLKAVSSAAIAEV 821
+ + VL + I L G V + +P L++ L + + + AI +
Sbjct: 261 HHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNI 320
Query: 822 GRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESLASHNALIQKAFLEKSLTK 881
E + GA+ +L + ++Q + + ++ + + + L
Sbjct: 321 VTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVP 380
Query: 882 YLLKLLKAFQIDVKEQGAVALWAL----AGQTLKQQKYMAEQIGYSFIINMLLSPSAKMQ 937
+L+ +L + D K Q A+WA+ +G T++Q Y+ ++N+L + K+
Sbjct: 381 FLVSVLS--KADFKTQ-KEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKII 437
Query: 938 YVGGEAV 944
V +A+
Sbjct: 438 LVILDAI 444
Score = 35.0 bits (79), Expect = 0.49
Identities = 32/147 (21%), Positives = 66/147 (44%), Gaps = 4/147 (2%)
Query: 634 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVG 693
LV++L A+ ++ I D+ + ++DAG + +LL + K +Q +
Sbjct: 298 LVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATW 357
Query: 694 LLSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSRC--AVILYDIAQCENKDVIAK 750
+SNI+ + + +V G +P L+++L + + AV Y + V
Sbjct: 358 TMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLV 417
Query: 751 YNG-IPSLINLLNLNIENVLVNVMNCI 776
+ G I L+NLL +++ +++ I
Sbjct: 418 HCGIIEPLMNLLTAKDTKIILVILDAI 444
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 54.3 bits (129), Expect = 8e-07
Identities = 47/165 (28%), Positives = 77/165 (46%), Gaps = 15/165 (9%)
Query: 462 GYTIFHHAALHNRVSIICQLC--NANFKVNQRRFVTFSQGPTPLHLAAQACSLETTVCLL 519
G+T H AA+ + + + L AN R G TPLHLAA T +L
Sbjct: 65 GWTASHIAAIRGQDACVQALIMNGANLTAQDDR------GCTPLHLAATHGHSFTLQIML 118
Query: 520 CSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSG 579
S D ++++KR W P+H+AAF+ + + L + S+ E N P+ LAA G
Sbjct: 119 RSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWGCSI---EDVDYNGNLPVHLAAMEG 175
Query: 580 ALDTIQYLFSIGAN----WRKTDIKGNNIIHLSVLTFHTEVLKYI 620
L ++L S ++ + + G N++ L+ F +L++I
Sbjct: 176 HLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI 220
Score = 42.4 bits (98), Expect = 0.003
Identities = 36/120 (30%), Positives = 48/120 (40%), Gaps = 6/120 (5%)
Query: 506 AAQACSLETTVCL---LCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEAE 562
A L VCL L AD T RGW H AA + AL +L
Sbjct: 36 AGDVKQLSEIVCLHWLLWHGADITHVTTRGWTASHIAAIRGQDACVQALIMNGANLT--- 92
Query: 563 ATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 622
A + CTPL LAAT G T+Q + G + TD + +H + L+ ++K
Sbjct: 93 AQDDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVK 152
Score = 33.5 bits (75), Expect = 1.4
Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 9/94 (9%)
Query: 535 PIHFAAFYDNVCIIIALCRKDPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANW 594
P H AAF ++ ++ L + ++ A+N TP+ AA G ++ +Q+L +GA+
Sbjct: 239 PGHVAAFKGDLGMLKKLV--EDGVININERADNGSTPMHKAAGQGHIECLQWLIKMGADS 296
Query: 595 RKTDIKG-------NNIIHLSVLTFHTEVLKYII 621
T+ G HL+ + E+ KY I
Sbjct: 297 NITNKAGERPSDVAKRFAHLAAVKLLEELQKYDI 330
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 53.5 bits (127), Expect = 1e-06
Identities = 50/192 (26%), Positives = 82/192 (42%), Gaps = 17/192 (8%)
Query: 438 GLSAVFHTFSRKTS---SSTINVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFV 494
GL + H S S +N D GYT HHAAL+ ++ L + N V
Sbjct: 53 GLGSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTN----V 108
Query: 495 TFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKR---GWMPIHFAAFYDNVCIIIAL 551
S+G PLHLAA + L+ +T ++ +H AA Y + ++ L
Sbjct: 109 ADSKGCYPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVL 168
Query: 552 CRK--DPSLLEAEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSV 609
+ DP++ + TPL LAA G L+ ++ L + N + K + +HL+
Sbjct: 169 LEELTDPTMRNNKFE-----TPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKHTPLHLAA 223
Query: 610 LTFHTEVLKYII 621
H V++ ++
Sbjct: 224 RNGHKAVVQVLL 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,673,329
Number of Sequences: 37866
Number of extensions: 2032053
Number of successful extensions: 6427
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 125
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 4962
Number of HSP's gapped (non-prelim): 1041
length of query: 1363
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1248
effective length of database: 13,892,928
effective search space: 17338374144
effective search space used: 17338374144
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.