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Search of human proteins with 90186267
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens]
(614 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens] 1252 0.0
gi|90186264 ankyrin repeat domain 55 isoform 2 [Homo sapiens] 667 0.0
gi|34304381 inversin isoform a [Homo sapiens] 148 1e-35
gi|34304379 inversin isoform b [Homo sapiens] 148 1e-35
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 128 2e-29
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 119 6e-27
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 112 8e-25
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 112 1e-24
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 108 1e-23
gi|30348954 mindbomb homolog 1 [Homo sapiens] 105 1e-22
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 103 6e-22
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 103 6e-22
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 103 6e-22
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 103 6e-22
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 103 6e-22
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 103 6e-22
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 102 1e-21
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 100 5e-21
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 100 5e-21
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 100 5e-21
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 99 9e-21
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 99 9e-21
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 98 2e-20
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 98 2e-20
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 97 3e-20
gi|155969701 espin-like [Homo sapiens] 96 1e-19
gi|50511945 cajalin 2 isoform a [Homo sapiens] 95 2e-19
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 95 2e-19
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 95 2e-19
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 95 2e-19
>gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens]
Length = 614
Score = 1252 bits (3240), Expect = 0.0
Identities = 614/614 (100%), Positives = 614/614 (100%)
Query: 1 MMRQATMDFSTPSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSE 60
MMRQATMDFSTPSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSE
Sbjct: 1 MMRQATMDFSTPSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSE 60
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH
Sbjct: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM
Sbjct: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAA 240
LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAA
Sbjct: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAA 240
Query: 241 AGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINEST 300
AGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINEST
Sbjct: 241 AGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINEST 300
Query: 301 PLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQIFCKNKKEEQRA 360
PLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQIFCKNKKEEQRA
Sbjct: 301 PLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQIFCKNKKEEQRA 360
Query: 361 HQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKKKTSDNSKYLLPE 420
HQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKKKTSDNSKYLLPE
Sbjct: 361 HQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKKKTSDNSKYLLPE 420
Query: 421 KKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQRSQKSRSEQDLL 480
KKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQRSQKSRSEQDLL
Sbjct: 421 KKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQRSQKSRSEQDLL 480
Query: 481 NNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQEVSVPPHLRHLHN 540
NNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQEVSVPPHLRHLHN
Sbjct: 481 NNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQEVSVPPHLRHLHN 540
Query: 541 PSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLPAIPSQRRHSTAA 600
PSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLPAIPSQRRHSTAA
Sbjct: 541 PSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLPAIPSQRRHSTAA 600
Query: 601 EESEHSANPTSDEN 614
EESEHSANPTSDEN
Sbjct: 601 EESEHSANPTSDEN 614
>gi|90186264 ankyrin repeat domain 55 isoform 2 [Homo sapiens]
Length = 326
Score = 667 bits (1722), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 289 MDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQ 348
MDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQ
Sbjct: 1 MDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRFNVLNQ 60
Query: 349 IFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKK 408
IFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKK
Sbjct: 61 IFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIVGTNCQEQPGDQVAMVEFKK 120
Query: 409 KTSDNSKYLLPEKKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQ 468
KTSDNSKYLLPEKKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQ
Sbjct: 121 KTSDNSKYLLPEKKPLARKGLPPIRTQSLPPITLGNNFLTASHRATSHAGLSSAPHHMAQ 180
Query: 469 RSQKSRSEQDLLNNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQE 528
RSQKSRSEQDLLNNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQE
Sbjct: 181 RSQKSRSEQDLLNNRTGCQMLLDNPWKSDSNQVFSYKVWTVSSSDKLLDRLLSVRPGHQE 240
Query: 529 VSVPPHLRHLHNPSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLP 588
VSVPPHLRHLHNPSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLP
Sbjct: 241 VSVPPHLRHLHNPSSGQNFQHLSPNRHKIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLP 300
Query: 589 AIPSQRRHSTAAEESEHSANPTSDEN 614
AIPSQRRHSTAAEESEHSANPTSDEN
Sbjct: 301 AIPSQRRHSTAAEESEHSANPTSDEN 326
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 148 bits (374), Expect = 1e-35
Identities = 98/294 (33%), Positives = 142/294 (48%), Gaps = 8/294 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
+ V+ AA NGD AL +I + ++ + D G TPLM+ V + D LLK GA++N
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
D RT+L LA G LL A D PLH T + L +LL+
Sbjct: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV----- 203
E++ QD T LHW+A++N P+H ++L+K ++ + D + K LHWA
Sbjct: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
Query: 204 QSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDV 263
+ + + C IL S++N+ D G+T +H A A G ++ L CN+ + D
Sbjct: 196 SAVHTVRC--ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 264 DDRTPLHWAAAAGKAECVQSLLELGMDSNL-RDINESTPLAYALYCGHTACVKL 316
RTPLHWAA G A+ V LLE + D +TPL YA VK+
Sbjct: 254 LFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKV 307
Score = 108 bits (269), Expect = 2e-23
Identities = 88/283 (31%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G + ++ + S DS+G TPL +A A+TVK+ LK + +
Sbjct: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLL--RNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
D GRTS A G + ++L ++ N+ DK G LHAA + + +L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ N ++++ D TPL A Q L+K GA LVD+D + LHWA G
Sbjct: 377 LE--NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL-ARVPECNLQALDVDD 265
N +C I++ + P N D +G+T + AA G+ + + L + N+Q D +
Sbjct: 435 NADVCQILIENKINP---NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ--DKEG 489
Query: 266 RTPLHWAAAAGKAECVQSLLELGMDSNLRDINES--TPLAYAL 306
RT LHW+ G + ++ LL+ N + NE TPL YAL
Sbjct: 490 RTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
Score = 98.6 bits (244), Expect = 1e-20
Identities = 85/278 (30%), Positives = 121/278 (43%), Gaps = 11/278 (3%)
Query: 52 SILECCDSEGCTPLMHAVSGRQADTVKLLLKM-GANINMQDAYGRTSLCLATYLGWLEGC 110
S+L D EG TPL AV+ V +L NI D RT L A LG +
Sbjct: 212 SLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIV 271
Query: 111 VSLLRNGAKHNIP-DKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWA 169
LL IP D G PLH A + V L+ ++ + D EG T WA
Sbjct: 272 HLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD--DSDLEGRTSFMWA 329
Query: 170 AFHNQPQ--HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYD 227
A T + LK D + DK TALH A SG+ ++L ++ + ++
Sbjct: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN---AQVDAT 386
Query: 228 DESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLEL 287
D T + A G D+I L + + +D D + LHWAA G A+ Q L+E
Sbjct: 387 DVMKHTPLFRACEMGHKDVIQTLIK-GGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Query: 288 GMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEP 325
++ N++D TPL A Y G+ C+ +L E+ +P
Sbjct: 446 KINPNVQDYAGRTPLQCAAYGGYINCMAVL-MENNADP 482
Score = 81.3 bits (199), Expect = 2e-15
Identities = 61/218 (27%), Positives = 100/218 (45%), Gaps = 6/218 (2%)
Query: 12 PSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSG 71
PSV D DS E + ++ A D T + + + D G T L A
Sbjct: 312 PSVKD----DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
Query: 72 RQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPL 131
TVKLLL+ A ++ D T L A +G + +L++ GA+ ++ D++G L
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427
Query: 132 HAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLV 191
H A + + +L++ N N QD G TPL AA+ +L++ ADP +
Sbjct: 428 HWAALGGNADVCQILIE--NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ 485
Query: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDE 229
DK+ +TALHW+ +G ++L P+ + ++E
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEE 523
Score = 70.1 bits (170), Expect = 6e-12
Identities = 50/189 (26%), Positives = 87/189 (46%), Gaps = 1/189 (0%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+++ + T +++A G + + +I+ + + D +G + L A G AD ++L
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARV-DLVDQDGHSLLHWAALGGNADVCQIL 442
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
++ N N+QD GRT L A Y G++ L+ N A NI DK GR LH + +
Sbjct: 443 IENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYL 502
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
+ +LL + + E TPL +A + + Q +L+ GA +D
Sbjct: 503 DAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKI 562
Query: 201 WAVQSGNRI 209
AV G ++
Sbjct: 563 QAVYKGYKV 571
Score = 38.1 bits (87), Expect = 0.024
Identities = 26/83 (31%), Positives = 36/83 (43%)
Query: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
VH AA G + L D RTPL + A + +C +LL+ G D N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 295 DINESTPLAYALYCGHTACVKLL 317
D ++ T L A G+ +KLL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLL 100
Score = 29.6 bits (65), Expect = 8.5
Identities = 24/91 (26%), Positives = 37/91 (40%), Gaps = 1/91 (1%)
Query: 227 DDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLE 286
+D+ G+T + A D L + ++ D RT LH AA G ++ LL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAG-ADVNKTDHSQRTALHLAAQKGNYRFMKLLLT 102
Query: 287 LGMDSNLRDINESTPLAYALYCGHTACVKLL 317
+ +D+ E TPL C+ LL
Sbjct: 103 RRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 148 bits (374), Expect = 1e-35
Identities = 98/294 (33%), Positives = 142/294 (48%), Gaps = 8/294 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
+ V+ AA NGD AL +I + ++ + D G TPLM+ V + D LLK GA++N
Sbjct: 16 SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
D RT+L LA G LL A D PLH T + L +LL+
Sbjct: 76 KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLK 135
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV----- 203
E++ QD T LHW+A++N P+H ++L+K ++ + D + K LHWA
Sbjct: 136 FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDP 195
Query: 204 QSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDV 263
+ + + C IL S++N+ D G+T +H A A G ++ L CN+ + D
Sbjct: 196 SAVHTVRC--ILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDN 253
Query: 264 DDRTPLHWAAAAGKAECVQSLLELGMDSNL-RDINESTPLAYALYCGHTACVKL 316
RTPLHWAA G A+ V LLE + D +TPL YA VK+
Sbjct: 254 LFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKV 307
Score = 108 bits (269), Expect = 2e-23
Identities = 88/283 (31%), Positives = 136/283 (48%), Gaps = 12/283 (4%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G + ++ + S DS+G TPL +A A+TVK+ LK + +
Sbjct: 257 TPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD 316
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLL--RNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
D GRTS A G + ++L ++ N+ DK G LHAA + + +L
Sbjct: 317 DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLL 376
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ N ++++ D TPL A Q L+K GA LVD+D + LHWA G
Sbjct: 377 LE--NNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGG 434
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL-ARVPECNLQALDVDD 265
N +C I++ + P N D +G+T + AA G+ + + L + N+Q D +
Sbjct: 435 NADVCQILIENKINP---NVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ--DKEG 489
Query: 266 RTPLHWAAAAGKAECVQSLLELGMDSNLRDINES--TPLAYAL 306
RT LHW+ G + ++ LL+ N + NE TPL YAL
Sbjct: 490 RTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL 532
Score = 98.6 bits (244), Expect = 1e-20
Identities = 85/278 (30%), Positives = 121/278 (43%), Gaps = 11/278 (3%)
Query: 52 SILECCDSEGCTPLMHAVSGRQADTVKLLLKM-GANINMQDAYGRTSLCLATYLGWLEGC 110
S+L D EG TPL AV+ V +L NI D RT L A LG +
Sbjct: 212 SLLNWQDYEGRTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIV 271
Query: 111 VSLLRNGAKHNIP-DKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWA 169
LL IP D G PLH A + V L+ ++ + D EG T WA
Sbjct: 272 HLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKD--DSDLEGRTSFMWA 329
Query: 170 AFHNQPQ--HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYD 227
A T + LK D + DK TALH A SG+ ++L ++ + ++
Sbjct: 330 AGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENN---AQVDAT 386
Query: 228 DESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLEL 287
D T + A G D+I L + + +D D + LHWAA G A+ Q L+E
Sbjct: 387 DVMKHTPLFRACEMGHKDVIQTLIK-GGARVDLVDQDGHSLLHWAALGGNADVCQILIEN 445
Query: 288 GMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEP 325
++ N++D TPL A Y G+ C+ +L E+ +P
Sbjct: 446 KINPNVQDYAGRTPLQCAAYGGYINCMAVL-MENNADP 482
Score = 81.3 bits (199), Expect = 2e-15
Identities = 61/218 (27%), Positives = 100/218 (45%), Gaps = 6/218 (2%)
Query: 12 PSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSG 71
PSV D DS E + ++ A D T + + + D G T L A
Sbjct: 312 PSVKD----DSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALS 367
Query: 72 RQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPL 131
TVKLLL+ A ++ D T L A +G + +L++ GA+ ++ D++G L
Sbjct: 368 GHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLL 427
Query: 132 HAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLV 191
H A + + +L++ N N QD G TPL AA+ +L++ ADP +
Sbjct: 428 HWAALGGNADVCQILIE--NKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQ 485
Query: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDE 229
DK+ +TALHW+ +G ++L P+ + ++E
Sbjct: 486 DKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEE 523
Score = 70.1 bits (170), Expect = 6e-12
Identities = 50/189 (26%), Positives = 87/189 (46%), Gaps = 1/189 (0%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+++ + T +++A G + + +I+ + + D +G + L A G AD ++L
Sbjct: 384 DATDVMKHTPLFRACEMGHKDVIQTLIKGGARV-DLVDQDGHSLLHWAALGGNADVCQIL 442
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
++ N N+QD GRT L A Y G++ L+ N A NI DK GR LH + +
Sbjct: 443 IENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYL 502
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
+ +LL + + E TPL +A + + Q +L+ GA +D
Sbjct: 503 DAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAFKI 562
Query: 201 WAVQSGNRI 209
AV G ++
Sbjct: 563 QAVYKGYKV 571
Score = 38.1 bits (87), Expect = 0.024
Identities = 26/83 (31%), Positives = 36/83 (43%)
Query: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
VH AA G + L D RTPL + A + +C +LL+ G D N
Sbjct: 18 VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 295 DINESTPLAYALYCGHTACVKLL 317
D ++ T L A G+ +KLL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLL 100
Score = 29.6 bits (65), Expect = 8.5
Identities = 24/91 (26%), Positives = 37/91 (40%), Gaps = 1/91 (1%)
Query: 227 DDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLE 286
+D+ G+T + A D L + ++ D RT LH AA G ++ LL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAG-ADVNKTDHSQRTALHLAAQKGNYRFMKLLLT 102
Query: 287 LGMDSNLRDINESTPLAYALYCGHTACVKLL 317
+ +D+ E TPL C+ LL
Sbjct: 103 RRANWMQKDLEEMTPLHLTTRHRSPKCLALL 133
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 128 bits (321), Expect = 2e-29
Identities = 107/362 (29%), Positives = 158/362 (43%), Gaps = 62/362 (17%)
Query: 31 VYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQ 90
++ AA G + L ++ L C D +G L A + Q + VK LL+MGA I+
Sbjct: 177 LHWAAFLGHLEVLKLLVARGAD-LGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEP 235
Query: 91 DAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQS 150
+A+G T+L +A YLG + L+ GA N P+ G PLH A + L LL +
Sbjct: 236 NAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL-VN 294
Query: 151 NISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRIL 210
N +++N+Q EG +PLH AA H + +Q+L++ G++ DK T LH A + G+ +L
Sbjct: 295 NGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELL 354
Query: 211 ---------------------------------CSIILSHHQGPSI-------------- 223
C +LS Q SI
Sbjct: 355 ISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGF 414
Query: 224 -INYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQ 282
IN D G+TC+H AA+ G + ++ L +L+ D RTPLH+AAA G +C
Sbjct: 415 DINTPDNLGRTCLHAAASGGNVECLN-LLLSSGADLRRRDKFGRTPLHYAAANGSYQCAV 473
Query: 283 SLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPP--PSQSSRPQKKE 340
+L+ G N D +PL YA R EP P ++ P K+
Sbjct: 474 TLVTAGAGVNEADCKGCSPLHYA---------AASDTYRRAEPHTPSSHDAEEDEPLKES 524
Query: 341 RR 342
RR
Sbjct: 525 RR 526
Score = 103 bits (256), Expect = 6e-22
Identities = 91/301 (30%), Positives = 141/301 (46%), Gaps = 12/301 (3%)
Query: 29 TMVYQAASNGDVNALTAVIR--EDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
T ++ AA++G ++L +I E I + D+ G TPLM A+ D V LLL+ G+
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
+ D GRT+L G + +LL + A D GR P+H A+A +L L
Sbjct: 714 ADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTL 773
Query: 147 LQQSNISEINHQ--DNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
LQ + ++ D G +P+HWA++ ++LL+ L F T LH AV
Sbjct: 774 LQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGNPF-TPLHCAVI 832
Query: 205 SGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARV--PECNLQALD 262
+ ++L G I+N D G+T +H AA F+D + L + + + A D
Sbjct: 833 NNQDSTTEMLLG-ALGAKIVNSRDAKGRTPLH---AAAFADNVSGLRMLLQHQAEVNATD 888
Query: 263 VDDRTPLHWAAAAGKAECVQSLLELG-MDSNLRDINESTPLAYALYCGHTACVKLLSQES 321
RT L AA G+ V+ LL G D + D N++T L A GH C ++ E+
Sbjct: 889 HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAET 948
Query: 322 R 322
+
Sbjct: 949 Q 949
Score = 102 bits (255), Expect = 8e-22
Identities = 88/271 (32%), Positives = 126/271 (46%), Gaps = 12/271 (4%)
Query: 52 SILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCV 111
S L D G + L HAV +TV LLL GA++N+ D R L A +LG LE
Sbjct: 131 SSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLK 190
Query: 112 SLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAF 171
L+ GA D+ G LH A A + ++ LL+ +EI+ + G T LH A +
Sbjct: 191 LLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG--AEIDEPNAFGNTALHIACY 248
Query: 172 HNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESG 231
Q L+ GA+ + T LH A S N LC +L ++ +NY + G
Sbjct: 249 LGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGAD--VNYQSKEG 306
Query: 232 KTCVHIAAAAG---FSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELG 288
K+ +H+AA G S I+ + +C D TPLH AA G + +L+ G
Sbjct: 307 KSPLHMAAIHGRFTRSQILIQNGSEIDC----ADKFGNTPLHVAARYGHELLISTLMTNG 362
Query: 289 MDSNLRDINESTPLAYALYCGHT-ACVKLLS 318
D+ R I++ PL A+ G + C KLLS
Sbjct: 363 ADTARRGIHDMFPLHLAVLFGFSDCCRKLLS 393
Score = 97.1 bits (240), Expect = 4e-20
Identities = 78/249 (31%), Positives = 125/249 (50%), Gaps = 6/249 (2%)
Query: 64 PLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIP 123
PL+ A+ R + V+ LL NIN+ D RT L A Y+G + LL +GA N
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 124 DKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLK 183
D PLH A A + ++L +LL S +++N +D TPLH AA + + + L
Sbjct: 71 DTLWLTPLHRAAASRNEKVLGLLLAHS--ADVNARDKLWQTPLHVAAANRATKCAEALAP 128
Query: 184 KGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGF 243
+ + D+ ++ALH AV SG+ +++L ++G S +N D+ + +H AA G
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLL--NKGAS-LNVCDKKERQPLHWAAFLGH 185
Query: 244 SDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLA 303
+++ +L +L D LH AAA+G+ E V+ LL +G + + + +T L
Sbjct: 186 LEVL-KLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALH 244
Query: 304 YALYCGHTA 312
A Y G A
Sbjct: 245 IACYLGQDA 253
Score = 92.8 bits (229), Expect = 8e-19
Identities = 84/301 (27%), Positives = 129/301 (42%), Gaps = 42/301 (13%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
D+ G T L A SG + + LLL GA++ +D +GRT L A G + V+L+ G
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAG 479
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
A N D G PLH A A R ++ + D E PL +
Sbjct: 480 AGVNEADCKGCSPLHYAAASDTYR-------RAEPHTPSSHDAEEDEPLKESRRKEAFFC 532
Query: 178 TQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIIL---------------------- 215
+ LL GADP+L D+ TA+H+A GNR ++L
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 216 ---SHHQ-----GPSIINYD--DESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDD 265
H + +++N D D G+T + +A G ++ + L L
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRK 652
Query: 266 RTPLHWAAAAGKAECVQSLLELGMDSNLRDINES---TPLAYALYCGHTACVKLLSQESR 322
TPLH AAA+G + + L++ G +++ D+ ++ TPL A+ GH CV LL ++
Sbjct: 653 WTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGS 712
Query: 323 T 323
T
Sbjct: 713 T 713
Score = 90.9 bits (224), Expect = 3e-18
Identities = 77/290 (26%), Positives = 135/290 (46%), Gaps = 6/290 (2%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
LT +++AA++ + L ++ + D TPL A + R + L + +++
Sbjct: 75 LTPLHRAAASRNEKVLGLLLAHSADV-NARDKLWQTPLHVAAANRATKCAEALAPLLSSL 133
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
N+ D GR++L A + G LE LL GA N+ DK R PLH A + +L +L+
Sbjct: 134 NVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193
Query: 148 QQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 207
+ +++ +D +G LH AA Q + + LL+ GA+ + TALH A G
Sbjct: 194 ARG--ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQ 251
Query: 208 RILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRT 267
++ + + +N ++ G T +H+AA + + EL ++ + ++
Sbjct: 252 D---AVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKS 308
Query: 268 PLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
PLH AA G+ Q L++ G + + D +TPL A GH + L
Sbjct: 309 PLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTL 358
Score = 90.5 bits (223), Expect = 4e-18
Identities = 90/327 (27%), Positives = 146/327 (44%), Gaps = 14/327 (4%)
Query: 18 QRGDSSEEVDL---TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQA 74
++G +++ DL T +++ A G + L A++ D +L C D +G TP+ A +
Sbjct: 709 EKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVL-CRDFKGRTPIHLASACGHT 767
Query: 75 DTVKLLLKMGANINMQDA----YGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLP 130
++ LL+ + + DA G + + A+Y G E C+ LL + + + N P
Sbjct: 768 AVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH-EDCLELLLEHSPFSYLEGNPFTP 826
Query: 131 LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTL 190
LH A +LL +N +D +G TPLH AAF + +MLL+ A+
Sbjct: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
Query: 191 VDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDI-IHE 249
D +TAL A ++G +L ++G + + DE+ T +H+A + G +
Sbjct: 887 TDHTGRTALMTAAENGQTAAVEFLL--YRGKADLTVLDENKNTALHLACSKGHEKCALMI 944
Query: 250 LARVPECNL-QALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTP-LAYALY 307
LA + L A + + PLH AA G A VQ+LL G D TP LA A
Sbjct: 945 LAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN 1004
Query: 308 CGHTACVKLLSQESRTEPTRPPPSQSS 334
C+ L+ + P + S S
Sbjct: 1005 KDVADCLALILSTMKPFPPKDAVSPFS 1031
Score = 87.4 bits (215), Expect = 3e-17
Identities = 84/308 (27%), Positives = 137/308 (44%), Gaps = 16/308 (5%)
Query: 13 SVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGR 72
+V DQ+R T ++ AA GDV L ++ ++ D+ TPL A + R
Sbjct: 35 NVLDQERR--------TPLHAAAYVGDVPILQLLLMSGANV-NAKDTLWLTPLHRAAASR 85
Query: 73 QADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLH 132
+ LLL A++N +D +T L +A + +L + N+ D++GR LH
Sbjct: 86 NEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALH 145
Query: 133 AATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVD 192
A + + +LL + + +N D + PLHWAAF + ++L+ +GAD D
Sbjct: 146 HAVHSGHLETVNLLLNKG--ASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKD 203
Query: 193 KDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELAR 252
+ LH A SG + +L + + I+ + G T +HIA G + EL
Sbjct: 204 RKGYGLLHTAAASGQIEVVKYLL---RMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN 260
Query: 253 VPECNLQALDVDDRTPLHWAAAAGK-AECVQSLLELGMDSNLRDINESTPLAYALYCGHT 311
N+ + TPLH AA + A C++ L+ G D N + +PL A G
Sbjct: 261 AG-ANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRF 319
Query: 312 ACVKLLSQ 319
++L Q
Sbjct: 320 TRSQILIQ 327
Score = 83.6 bits (205), Expect = 5e-16
Identities = 79/292 (27%), Positives = 125/292 (42%), Gaps = 8/292 (2%)
Query: 27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
D + QA + DV + +++ + +I D E TPL A ++LLL GAN
Sbjct: 8 DQPPLVQAIFSRDVEEVRSLLSQKENI-NVLDQERRTPLHAAAYVGDVPILQLLLMSGAN 66
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
+N +D T L A + LL + A N DK + PLH A A + L
Sbjct: 67 VNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEAL 126
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
+S +N D G + LH A + +LL KGA + DK + LHWA G
Sbjct: 127 APL--LSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG 184
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
+ + ++++ + + D G +H AAA+G +++ L R+ + +
Sbjct: 185 HLEVLKLLVAR---GADLGCKDRKGYGLLHTAAASGQIEVVKYLLRM-GAEIDEPNAFGN 240
Query: 267 TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTA-CVKLL 317
T LH A G+ L+ G + N + TPL A + A C++LL
Sbjct: 241 TALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL 292
Score = 80.5 bits (197), Expect = 4e-15
Identities = 81/330 (24%), Positives = 140/330 (42%), Gaps = 38/330 (11%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSG---RQADT--------- 76
T ++ AA+NG ++ + E D +GC+PL +A + R+A+
Sbjct: 458 TPLHYAAANGSYQCAVTLVTAGAGVNEA-DCKGCSPLHYAAASDTYRRAEPHTPSSHDAE 516
Query: 77 ----------------VKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
++ LL GA+ +++D G T++ A G + + LL + +
Sbjct: 517 EDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQN-LELLLEMSFN 575
Query: 121 NIPDKNGRL---PLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
+ D + PLH A L L + + ++ +D++G T L A +
Sbjct: 576 CLEDVESTIPVSPLHLAAYNGHCEALKTLAE--TLVNLDVRDHKGRTALFLATERGSTEC 633
Query: 178 TQMLLKKGADPTLVDKDFK-TALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVH 236
++L GA + ++ K T LH A SG+ +++ + I + D G+T +
Sbjct: 634 VEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLM 693
Query: 237 IAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDI 296
+A G D +H L A D+ RT LH A G +C+ +LL+ RD
Sbjct: 694 LAIMNGHVDCVHLLLE-KGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDF 752
Query: 297 NESTPLAYALYCGHTACVKLLSQES-RTEP 325
TP+ A CGHTA ++ L Q + T+P
Sbjct: 753 KGRTPIHLASACGHTAVLRTLLQAALSTDP 782
Score = 41.6 bits (96), Expect = 0.002
Identities = 33/95 (34%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 224 INYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQS 283
IN D+ +T +H AA G I+ +L + N+ A D TPLH AAA+ + +
Sbjct: 34 INVLDQERRTPLHAAAYVGDVPIL-QLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGL 92
Query: 284 LLELGMDSNLRDINESTPLAYALYCGHTACVKLLS 318
LL D N RD TPL A T C + L+
Sbjct: 93 LLAHSADVNARDKLWQTPLHVAAANRATKCAEALA 127
Score = 31.2 bits (69), Expect = 2.9
Identities = 20/57 (35%), Positives = 28/57 (49%)
Query: 261 LDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
L + D+ PL A + E V+SLL + N+ D TPL A Y G ++LL
Sbjct: 4 LSITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLL 60
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 119 bits (299), Expect = 6e-27
Identities = 94/299 (31%), Positives = 146/299 (48%), Gaps = 12/299 (4%)
Query: 29 TMVYQAASNGDVNALTAVI--REDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
T ++ AA+NG L +I E + ++ D G TPLM +V D V LL GAN
Sbjct: 619 TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN 678
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
++ +D +GRT+L G E +LL++GAK + D GR P+H + A + +L L
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 147 LQQSNISEIN--HQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
LQ + + N DN G T LHWA ++ ++LL++ F + LH AV
Sbjct: 739 LQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAF-SPLHCAVI 797
Query: 205 SGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
+ N +++ G SI+N D G+T +H AA F+D + L + N Q VD
Sbjct: 798 NDNEGAAEMLID-TLGASIVNATDSKGRTPLH---AAAFTDHVECLQLLLSHNAQVNSVD 853
Query: 265 D--RTPLHWAAAAGKAECVQSLL-ELGMDSNLRDINESTPLAYALYCGHTACVKLLSQE 320
+TPL AA G+ V+ L+ + L+D +++T L A GH L+ ++
Sbjct: 854 STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEK 912
Score = 114 bits (284), Expect = 3e-25
Identities = 89/294 (30%), Positives = 143/294 (48%), Gaps = 12/294 (4%)
Query: 27 DLTMVYQAASNGDVNALTAVI--REDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMG 84
D + QA NGD + + A+I +ED + D+E TPL A A+ ++LL+ G
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQ---DNEKRTPLHAAAYLGDAEIIELLILSG 64
Query: 85 ANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLT 144
A +N +D+ T L A E LL++ A N DKN + PLH A A ++
Sbjct: 65 ARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAE 124
Query: 145 VLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
L+ +S +N D G T LH AAF + ++LL +GA+ DK + A+HWA
Sbjct: 125 ALVPL--LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAY 182
Query: 205 SGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
G+ + +++SH + + D+ T +H AA++G ++ L + ++ +
Sbjct: 183 MGHIEVVKLLVSH---GAEVTCKDKKSYTPLHAAASSGMISVVKYLLDL-GVDMNEPNAY 238
Query: 265 DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTA-CVKLL 317
TPLH A G+ V L++ G N ++ TPL +A H A C++LL
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Score = 107 bits (266), Expect = 4e-23
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 37/321 (11%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA+N V A++ ++ D G T L HA + VKLLL GANIN
Sbjct: 109 TPLHIAAANKAVKCAEALVPLLSNV-NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANIN 167
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL- 147
D R ++ A Y+G +E L+ +GA+ DK PLHAA + + ++ LL
Sbjct: 168 AFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 148 -----------------------QQSNISE-------INHQDNEGMTPLHWAAFHNQ-PQ 176
Q ++E +N ++ +G TPLH+AA
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Query: 177 HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVH 236
++L+ GAD + KD KT LH G I+ Q ++I+ +D++G T +H
Sbjct: 288 CLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTII---QSGAVIDCEDKNGNTPLH 344
Query: 237 IAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDI 296
IAA G +I+ L + + PLH AA +G ++C + LL G D + D
Sbjct: 345 IAARYGHELLINTLI-TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDD 403
Query: 297 NESTPLAYALYCGHTACVKLL 317
T L A G+ C+ LL
Sbjct: 404 FGRTCLHAAAAGGNLECLNLL 424
Score = 103 bits (256), Expect = 6e-22
Identities = 89/303 (29%), Positives = 141/303 (46%), Gaps = 22/303 (7%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A +G + +I+ ++++C D G TPL A + L+ GA+
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSG-AVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTA 366
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+ +G L LA G+ + C LL +G + PD GR LHAA A ++ L +LL
Sbjct: 367 KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLN 426
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
++ N +D G +PLH+AA + Q L+ GA +D+ T LH+A S
Sbjct: 427 TG--ADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTD 484
Query: 209 ILC-SIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQAL------ 261
C +L + P I D+ G VH +AA G + +A E L L
Sbjct: 485 GKCLEYLLRNDANPGI---RDKQGYNAVHYSAAYGHRLCLQLIA--SETPLDVLMETSGT 539
Query: 262 ----DVDDR---TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACV 314
D D+R +PLH AA G + ++ L++ +D ++R+ + TPL A + GH CV
Sbjct: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
Query: 315 KLL 317
+L
Sbjct: 600 DVL 602
Score = 101 bits (251), Expect = 2e-21
Identities = 82/314 (26%), Positives = 149/314 (47%), Gaps = 22/314 (7%)
Query: 31 VYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAV-SGRQADTVKLLLKMGANINM 89
++ AA+N + L A++ S+ + D GCTPL +A S ++ LL+ AN +
Sbjct: 442 LHYAAANCNYQCLFALVGSGASVNDL-DERGCTPLHYAATSDTDGKCLEYLLRNDANPGI 500
Query: 90 QDAYGRTSLCLATYLGW---LEGCVS------LLRNGAKHNIPDKNGRL---PLHAATAE 137
+D G ++ + G L+ S L+ + D + R PLH A
Sbjct: 501 RDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYH 560
Query: 138 PDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDF-- 195
+ L VL+Q ++ +++ +++ G TPL AAF + +L+ +GA +++ KD+
Sbjct: 561 GHHQALEVLVQ--SLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGA--SILVKDYIL 616
Query: 196 -KTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVP 254
+T +H A +G+ +++ + + + ++ D +G+T + ++ G +D ++ L
Sbjct: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLN-K 675
Query: 255 ECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACV 314
N+ A D RT LH A G ECV +LL+ G LRD TP+ + CGH +
Sbjct: 676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVL 735
Query: 315 KLLSQESRTEPTRP 328
L Q + + P
Sbjct: 736 GALLQSAASMDANP 749
Score = 80.1 bits (196), Expect = 6e-15
Identities = 87/324 (26%), Positives = 140/324 (43%), Gaps = 51/324 (15%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+ ++ T +++ A G + A+++ L DS G TP+ + + + L
Sbjct: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCL-LRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 81 LK----MGANINMQDAYGRTSLCLATYLGWLEGCVSLL---------------------- 114
L+ M AN D +G T+L A Y G E CV LL
Sbjct: 739 LQSAASMDANPATADNHGYTALHWACYNGH-ETCVELLLEQEVFQKTEGNAFSPLHCAVI 797
Query: 115 --RNGAKH-----------NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNE 161
GA N D GR PLHAA + L +LL S+ +++N D+
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLL--SHNAQVNSVDST 855
Query: 162 GMTPLHWAAFHNQPQHTQMLLKKG-ADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQG 220
G TPL AA + Q +ML+ A+ TL D TALH A G+ +IL
Sbjct: 856 GKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITD 915
Query: 221 PSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP-LHWAAAAGKAE 279
++IN + + +T +H+AA G + ++ EL ++ A+D + TP L A A+
Sbjct: 916 RNLINATNAALQTPLHVAARNGLTMVVQELLG-KGASVLAVDENGYTPALACAPNKDVAD 974
Query: 280 CVQSLLELGMDSNLRDINESTPLA 303
C+ +L + + ++ S+PL+
Sbjct: 975 CLALIL-----ATMMPVSSSSPLS 993
Score = 35.4 bits (80), Expect = 0.16
Identities = 22/60 (36%), Positives = 31/60 (51%)
Query: 262 DVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQES 321
D + RTPLH AA G AE ++ L+ G N +D TPL A+ V++L + S
Sbjct: 38 DNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 112 bits (281), Expect = 8e-25
Identities = 81/261 (31%), Positives = 129/261 (49%), Gaps = 7/261 (2%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
DSE TPL A A+ ++LL+ GA +N +D T L A E L+++
Sbjct: 13 DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
A N DKN + PLH A A ++ V++ +S +N D G T LH AA + +
Sbjct: 73 ADVNARDKNWQTPLHVAAANKAVKCAEVIIPL--LSSVNVSDRGGRTALHHAALNGHVEM 130
Query: 178 TQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHI 237
+LL KGA+ DK + ALHWA G+ + +++++H + + D+ G T +H
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH---GAEVTCKDKKGYTPLHA 187
Query: 238 AAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDIN 297
AA+ G +++ L + + ++V T LH A G+ V L++ G + N + N
Sbjct: 188 AASNGQINVVKHLLNL-GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNN 246
Query: 298 ESTPLAYALYCGHTA-CVKLL 317
TPL +A H A C++LL
Sbjct: 247 GFTPLHFAAASTHGALCLELL 267
Score = 110 bits (275), Expect = 4e-24
Identities = 92/302 (30%), Positives = 142/302 (47%), Gaps = 11/302 (3%)
Query: 29 TMVYQAASNGDVNALTAV--IREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
T ++ + NG L + I ++P ++ D++G TPLM AV+ D V LLL+ AN
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
++ D G T+L G E LL D GR PLH A A L+ L
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSEL 730
Query: 147 LQQS-NISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV-- 203
LQ + + + +DN+G TPLHWA ++ ++LL++ + F T LH A+
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPF-TPLHCAIIN 789
Query: 204 QSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDV 263
GN C+ +L SI++ D+ G+T + AA A + + L R + A+D
Sbjct: 790 DHGN---CASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLR-HSAPVNAVDN 845
Query: 264 DDRTPLHWAAAAGKAECVQSLLELGM-DSNLRDINESTPLAYALYCGHTACVKLLSQESR 322
+T L AA G+A V L+ D ++D + +TPL A GH C L+ + +
Sbjct: 846 SGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQ 905
Query: 323 TE 324
E
Sbjct: 906 DE 907
Score = 109 bits (272), Expect = 8e-24
Identities = 104/390 (26%), Positives = 161/390 (41%), Gaps = 92/390 (23%)
Query: 24 EEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKM 83
++ D ++ AA G ++ + +I + C D +G TPL A S Q + VK LL +
Sbjct: 145 DKKDRRALHWAAYMGHLDVVALLINHGAEVT-CKDKKGYTPLHAAASNGQINVVKHLLNL 203
Query: 84 GANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLL 143
G I+ + YG T+L +A Y G L+ GA N P+ NG PLH A A L
Sbjct: 204 GVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALC 263
Query: 144 TVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV 203
LL +N +++N Q +G +PLH A H + +Q L++ G + VDKD T LH A
Sbjct: 264 LELLV-NNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAA 322
Query: 204 QSGNRILCSIILS----------HHQGPSI--------------------INYDDESGKT 233
+ G+ +L + + + H P I+ D+ G+T
Sbjct: 323 RYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRT 382
Query: 234 CVHIAAAAGFSDIIHEL-------------ARVP------ECNLQALDV----------- 263
C+H AAA G + I L R P C+ ++
Sbjct: 383 CLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNET 442
Query: 264 DD--RTPLHWAAAA---------GKAE-------------------CVQSLLELGMDSNL 293
DD RT LH+AAA+ G A C++ LL+ + ++
Sbjct: 443 DDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSI 502
Query: 294 RDINESTPLAYALYCGHTACVKLLSQESRT 323
RD + YA GH C++LL + + +
Sbjct: 503 RDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
Score = 108 bits (269), Expect = 2e-23
Identities = 93/321 (28%), Positives = 137/321 (42%), Gaps = 37/321 (11%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA+N V +I S+ D G T L HA + V LLL GANIN
Sbjct: 84 TPLHVAAANKAVKCAEVIIPLLSSV-NVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN 142
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL- 147
D R +L A Y+G L+ L+ +GA+ DK G PLHAA + + ++ LL
Sbjct: 143 AFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN 202
Query: 148 -----------------------QQSNISE-------INHQDNEGMTPLHWAAFHNQ-PQ 176
Q + ++E +N +N G TPLH+AA
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGAL 262
Query: 177 HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVH 236
++L+ GAD + KD K+ LH G ++ Q I+ D+ G T +H
Sbjct: 263 CLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLI---QNGGEIDCVDKDGNTPLH 319
Query: 237 IAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDI 296
+AA G +I+ L R + + PLH AA ++C + LL G + + D
Sbjct: 320 VAARYGHELLINTL-RTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDK 378
Query: 297 NESTPLAYALYCGHTACVKLL 317
T L A G+ C+KLL
Sbjct: 379 FGRTCLHAAAAGGNVECIKLL 399
Score = 99.4 bits (246), Expect = 9e-21
Identities = 85/294 (28%), Positives = 132/294 (44%), Gaps = 41/294 (13%)
Query: 57 CDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
C PL A +D + LL G I+ D +GRT L A G +E C+ LL++
Sbjct: 343 CGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE-CIKLLQS 401
Query: 117 -GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQP 175
GA + DK GR PLH A A + L+ + +N D+ G T LH+AA +
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG--ANVNETDDWGRTALHYAAASDMD 459
Query: 176 QH----------------------------TQMLLKKGADPTLVDKDFKTALHWAVQSGN 207
++ + LL+ A+P++ DK+ ++H+A G+
Sbjct: 460 RNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGH 519
Query: 208 RILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDD-- 265
R C +L D + K+ +H+AA G H+ V +L LD+ D
Sbjct: 520 R-QCLELLLERTNSGFEESDSGATKSPLHLAAYNGH----HQALEVLLQSLVDLDIRDEK 574
Query: 266 -RTPLHWAAAAGKAECVQSLLELGMDSNLRD-INESTPLAYALYCGHTACVKLL 317
RT L AA G ECV++L+ G ++D + + TPL ++ GHT C++LL
Sbjct: 575 GRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Score = 99.0 bits (245), Expect = 1e-20
Identities = 93/366 (25%), Positives = 151/366 (41%), Gaps = 64/366 (17%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+ ++ T ++ AA+ G+V + +++ + D G TPL +A + ++ L
Sbjct: 374 DTPDKFGRTCLHAAAAGGNVECIK-LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL 432
Query: 81 LKMGANINMQDAYGRTSLCLA---------TYLGWLEG------------------CVS- 112
+ GAN+N D +GRT+L A T LG C+
Sbjct: 433 VTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEF 492
Query: 113 LLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFH 172
LL+N A +I DK G +H A A + L +LL+++N +PLH AA++
Sbjct: 493 LLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYN 552
Query: 173 NQPQHTQMLLKKGADPTLVDKDFKTA---------------------------------- 198
Q ++LL+ D + D+ +TA
Sbjct: 553 GHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTP 612
Query: 199 LHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNL 258
LH +V +G+ + ++L P ++ D G+T + +A A G D + L E N+
Sbjct: 613 LHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV-SLLLEKEANV 671
Query: 259 QALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLS 318
+D+ T LH G ECVQ LLE + +D TPL YA GH + L
Sbjct: 672 DTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELL 731
Query: 319 QESRTE 324
Q + +E
Sbjct: 732 QMALSE 737
Score = 98.2 bits (243), Expect = 2e-20
Identities = 91/313 (29%), Positives = 144/313 (46%), Gaps = 17/313 (5%)
Query: 10 STPSVFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGC-TPLMHA 68
+ PS+ D++ +S ++ AA+ G L ++ S E DS +PL A
Sbjct: 498 ANPSIRDKEGYNS--------IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 69 VSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDK-NG 127
+++LL+ +++++D GRT+L LA + G E +L+ GA + D
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
Query: 128 RLPLHAATAEPDMRLLTVLLQ-QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGA 186
R PLHA+ L +LL+ N ++ +D +G TPL A + +LL+K A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 187 DPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDI 246
+ VD TALH + +G+ ++L Q SI+ D G+T +H AAA G +
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLL--EQEVSIL-CKDSRGRTPLHYAAARGHATW 726
Query: 247 IHELARVPECNLQALDVDDR--TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAY 304
+ EL ++ D++ TPLHWA G C++ LLE N TPL
Sbjct: 727 LSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHC 785
Query: 305 ALYCGHTACVKLL 317
A+ H C LL
Sbjct: 786 AIINDHGNCASLL 798
Score = 94.7 bits (234), Expect = 2e-19
Identities = 85/293 (29%), Positives = 128/293 (43%), Gaps = 34/293 (11%)
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
++C D +G TPL A + L GA+ + L LA + C L
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L +G + + PDK GR LHAA A ++ + +L QS+ ++ + +D G TPLH+AA +
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL--QSSGADFHKKDKCGRTPLHYAAANC 424
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQS---------GN----------------- 207
+ L+ GA+ D +TALH+A S GN
Sbjct: 425 HFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEK 484
Query: 208 -RILC-SIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD- 264
LC +L + PSI D+ G +H AAA G + L + D
Sbjct: 485 EATLCLEFLLQNDANPSI---RDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGA 541
Query: 265 DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
++PLH AA G + ++ LL+ +D ++RD T L A + GHT CV+ L
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEAL 594
Score = 70.9 bits (172), Expect = 3e-12
Identities = 55/167 (32%), Positives = 82/167 (49%), Gaps = 10/167 (5%)
Query: 154 EINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSI 213
++N D+E TPLH AAF + ++L+ GA D + T LH AV S + +
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 214 ILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDD---RTPLH 270
++ H + +N D++ +T +H+AAA + + A V L +++V D RT LH
Sbjct: 68 LIKH---SADVNARDKNWQTPLHVAAA----NKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 271 WAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
AA G E V LL G + N D + L +A Y GH V LL
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Score = 67.4 bits (163), Expect = 4e-11
Identities = 71/251 (28%), Positives = 104/251 (41%), Gaps = 41/251 (16%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+ + + T +++ G + ++ ++ SIL C DS G TPL +A + A + L
Sbjct: 672 DTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL-CKDSRGRTPLHYAAARGHATWLSEL 730
Query: 81 LKMGANIN---MQDAYGRTSLCLATYLG-------WLE---------------------- 108
L+M + +D G T L A Y G LE
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIIND 790
Query: 109 --GCVSLLRNGAKHNIP---DKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGM 163
C SLL +I D GR PL AA + L +LL+ S + +N DN G
Sbjct: 791 HGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHS--APVNAVDNSGK 848
Query: 164 TPLHWAAFHNQPQHTQMLLKKG-ADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPS 222
T L AA + Q +L+ AD T+ DKD T LH A G+ +IL Q S
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDES 908
Query: 223 IINYDDESGKT 233
+IN + + +T
Sbjct: 909 LINEKNNALQT 919
Score = 37.4 bits (85), Expect = 0.041
Identities = 23/65 (35%), Positives = 34/65 (52%)
Query: 257 NLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKL 316
++ LD + RTPLH AA G AE ++ L+ G N +D TPL A+ V++
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 317 LSQES 321
L + S
Sbjct: 68 LIKHS 72
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 112 bits (279), Expect = 1e-24
Identities = 91/299 (30%), Positives = 146/299 (48%), Gaps = 22/299 (7%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T + AA G ++A++ + +C D++ T L A G D V LL+ GA +N
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKV-DCADADSRTALRAAAWGGHEDIVLNLLQHGAEVN 671
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAA-----TAEPDMRLL 143
D GRT+L A Y+G E LL +GA+ N D +GR L A ++ ++
Sbjct: 672 KADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVV 731
Query: 144 TVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV 203
++L+ + +E++H D +GMTPL AA+ +LL+ GAD D + +T L A
Sbjct: 732 SLLIDRG--AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 204 QSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDV 263
G+ + + +L G ++ + D E G+T + IA+A G +++ L + LD
Sbjct: 790 SMGHASVVNTLL--FWGAAVDSIDSE-GRTVLSIASAQGNVEVVRTLLD------RGLDE 840
Query: 264 DDR-----TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
+ R TPLH AA G ++L+E G +N D + P A GH CV++L
Sbjct: 841 NHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL 899
Score = 111 bits (277), Expect = 2e-24
Identities = 85/272 (31%), Positives = 136/272 (50%), Gaps = 12/272 (4%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
D +G T L A G + V LL G ++ DA RT+L A + G + ++LL++G
Sbjct: 608 DQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHG 667
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAF-----H 172
A+ N D GR L AA ++ LL +E+NH+D +G T L AA
Sbjct: 668 AEVNKADNEGRTALIAAAYMGHREIVEHLLDHG--AEVNHEDVDGRTALSVAALCVPASK 725
Query: 173 NQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGK 232
+L+ +GA+ DKD T L A G+ + ++L +G + +++ D +G+
Sbjct: 726 GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLL---EGGADVDHTDNNGR 782
Query: 233 TCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSN 292
T + AA+ G + +++ L + ++D + RT L A+A G E V++LL+ G+D N
Sbjct: 783 TPLLAAASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDEN 841
Query: 293 LRDINESTPLAYALYCGH-TACVKLLSQESRT 323
RD TPL A + GH C L+ Q +RT
Sbjct: 842 HRDDAGWTPLHMAAFEGHRLICEALIEQGART 873
Score = 102 bits (254), Expect = 1e-21
Identities = 83/249 (33%), Positives = 118/249 (47%), Gaps = 13/249 (5%)
Query: 75 DTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAA 134
D+++ LL GA++N D+ GRT L A Y G L+ L+ GA I D +G PL A
Sbjct: 526 DSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLA 585
Query: 135 TAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKD 194
+ +++ L+ + INH D +G T L AA+ + LL G D D
Sbjct: 586 ARQGHTKVVNCLIGCG--ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADAD 643
Query: 195 FKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDII-HELARV 253
+TAL A G+ I+L+ Q + +N D G+T + AA G +I+ H L
Sbjct: 644 SRTALRAAAWGGHE---DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 254 PECNLQALDVDDRTPLHWA-----AAAGKAECVQSLLELGMDSNLRDINESTPLAYALYC 308
E N + DVD RT L A A+ G A V L++ G + + D + TPL A Y
Sbjct: 701 AEVNHE--DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758
Query: 309 GHTACVKLL 317
GH V LL
Sbjct: 759 GHVDVVDLL 767
Score = 102 bits (253), Expect = 1e-21
Identities = 85/270 (31%), Positives = 124/270 (45%), Gaps = 19/270 (7%)
Query: 57 CDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
CDS G T L +A D V LL+ GA++ ++DA+G T L LA G + L+
Sbjct: 541 CDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGC 600
Query: 117 GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQ 176
GA N D++G L +A +++ LL +++ D + T L AA+
Sbjct: 601 GANINHTDQDGWTALRSAAWGGHTEVVSALLYAG--VKVDCADADSRTALRAAAWGGHED 658
Query: 177 HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVH 236
LL+ GA+ D + +TAL A G+R + +L H + +N++D G+T +
Sbjct: 659 IVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH---GAEVNHEDVDGRTALS 715
Query: 237 IAA---------AAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLEL 287
+AA A+ S +I A V C D D TPL AA G + V LLE
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDHC-----DKDGMTPLLVAAYEGHVDVVDLLLEG 770
Query: 288 GMDSNLRDINESTPLAYALYCGHTACVKLL 317
G D + D N TPL A GH + V L
Sbjct: 771 GADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 92.4 bits (228), Expect = 1e-18
Identities = 85/298 (28%), Positives = 132/298 (44%), Gaps = 11/298 (3%)
Query: 25 EVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMG 84
+ D +AA+ G + + + + + D+EG T L+ A + V+ LL G
Sbjct: 641 DADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHG 700
Query: 85 ANINMQDAYGRT-----SLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPD 139
A +N +D GRT +LC+ G L+ GA+ + DK+G PL A E
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
Query: 140 MRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTAL 199
+ ++ +LL+ ++++H DN G TPL AA LL GA +D + +T L
Sbjct: 761 VDVVDLLLEGG--ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818
Query: 200 HWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQ 259
A GN + +L N+ D++G T +H+AA G +I E
Sbjct: 819 SIASAQGNVEVVRTLLDRGLDE---NHRDDAGWTPLHMAAFEGHR-LICEALIEQGARTN 874
Query: 260 ALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
+D D R P A+ G +CVQ LLE + + R + L A GH V+LL
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Score = 91.7 bits (226), Expect = 2e-18
Identities = 90/355 (25%), Positives = 151/355 (42%), Gaps = 46/355 (12%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D ++ T + AAS G + + ++ ++ + DSEG T L A + + V+ L
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAV-DSIDSEGRTVLSIASAQGNVEVVRTL 833
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
L G + N +D G T L +A + G C +L+ GA+ N D +GR+P A+ E
Sbjct: 834 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHY 893
Query: 141 RLLTVLLQ-QSNI------------------------------SEINHQDNEGMTPLHWA 169
+ +LL+ +SNI +++N +D +G L+
Sbjct: 894 DCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYIL 953
Query: 170 AFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDE 229
A NQ + L+ GA+ D + +TALH + G+ + +++++H + +N D
Sbjct: 954 ALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH---ADVNAADN 1010
Query: 230 SGKTCVHIAAAAGFSDII-----HELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSL 284
++ + AA G ++ H CN A T L AA G + VQ L
Sbjct: 1011 EKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGA------TALCIAAQEGHIDVVQVL 1064
Query: 285 LELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKK 339
LE G D N D T + A GH+ +KLL + + PS ++K
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQK 1119
Score = 86.7 bits (213), Expect = 6e-17
Identities = 78/263 (29%), Positives = 126/263 (47%), Gaps = 16/263 (6%)
Query: 63 TPLMHAVSG---RQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAK 119
TP+ ++S ++ + ++LL+K GA++N +D RTS + L + +LL NGA
Sbjct: 480 TPVRDSLSTLIPKEQEVLQLLVKAGAHVNSED--DRTSCIVRQALEREDSIRTLLDNGAS 537
Query: 120 HNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQ 179
N D NGR L A + ++ +L+ + +++ +D G TPL AA +
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRG--ADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 180 MLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA 239
L+ GA+ D+D TAL A G+ + S +L + G ++ D +T + AA
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALL--YAGVK-VDCADADSRTALRAAA 652
Query: 240 AAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINES 299
G DI+ L + + D + RT L AA G E V+ LL+ G + N D++
Sbjct: 653 WGGHEDIVLNLLQ-HGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGR 711
Query: 300 TPLAYALYC-----GHTACVKLL 317
T L+ A C GH + V LL
Sbjct: 712 TALSVAALCVPASKGHASVVSLL 734
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 108 bits (271), Expect = 1e-23
Identities = 97/309 (31%), Positives = 145/309 (46%), Gaps = 15/309 (4%)
Query: 17 QQRGDSSEEVDLTMVYQAASNGDVNALTAVIRED--PSILECCDSEG-CTPLMHAVSGRQ 73
+Q G+ +E++ ++ + N AL R++ P E C E TPL V+
Sbjct: 315 RQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGS 374
Query: 74 ADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHA 133
+ V+LLL +++ Q A G T L +A + C LL +GA N D++G PLH
Sbjct: 375 VEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHF 434
Query: 134 ATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDK 193
A D +LL + ++ Q+ EG TPLH AA +N ++L+ + ADP L +
Sbjct: 435 AAQNGDDGTARLLLDHG--ACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEA 492
Query: 194 DFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELAR- 252
+ KT LH A G+ L ++ S QG ++ + +T +H+A G I L +
Sbjct: 493 EGKTPLHVAAYFGHVSLVKLLTS--QGAE-LDAQQRNLRTPLHLAVERGKVRAIQHLLKS 549
Query: 253 --VPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGH 310
VP+ ALD PLH AAA GK + LL G L TPL A Y GH
Sbjct: 550 GAVPD----ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGH 605
Query: 311 TACVKLLSQ 319
+ LL++
Sbjct: 606 LEIIHLLAE 614
Score = 95.9 bits (237), Expect = 1e-19
Identities = 86/289 (29%), Positives = 132/289 (45%), Gaps = 13/289 (4%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVI--REDPSILECCDSEGCTPLMHAVSGRQADTVK 78
D+ E T ++ AA N N ++ + DP++ E +EG TPL A VK
Sbjct: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHE---AEGKTPLHVAAYFGHVSLVK 511
Query: 79 LLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEP 138
LL GA ++ Q RT L LA G + LL++GA + D++G PLH A A
Sbjct: 512 LLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARG 571
Query: 139 DMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTA 198
+ +LL+ E+ ++G TPLH AA+ + +L + A+ + T
Sbjct: 572 KYLICKMLLRYGASLEL--PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP 629
Query: 199 LHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAG-FSDIIHELARVPECN 257
LH A + G + S +L P N ++SG T +H+A F +I+ L N
Sbjct: 630 LHLAARHGEEAVVSALLQCGADP---NAAEQSGWTPLHLAVQRSTFLSVINLLEH--HAN 684
Query: 258 LQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYAL 306
+ A + TP H AA G ++ L+E G +++D TPL AL
Sbjct: 685 VHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLAL 733
Score = 94.0 bits (232), Expect = 4e-19
Identities = 81/273 (29%), Positives = 121/273 (44%), Gaps = 40/273 (14%)
Query: 34 AASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAY 93
AA NGD + ++ + + ++ + EG TPL A + +LL+ A+ N+ +A
Sbjct: 435 AAQNGD-DGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493
Query: 94 GRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNIS 153
G+T L +A Y G + L GA+ + +N R PLH A +R + LL+ +
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 154 EINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSI 213
+ D G PLH AA + +MLL+ GA S+
Sbjct: 554 DA--LDQSGYGPLHTAAARGKYLICKMLLRYGA-------------------------SL 586
Query: 214 ILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAA 273
L HQ G T +H+AA G +IIH LA N+ AL + TPLH AA
Sbjct: 587 ELPTHQ-----------GWTPLHLAAYKGHLEIIHLLAE-SHANMGALGAVNWTPLHLAA 634
Query: 274 AAGKAECVQSLLELGMDSNLRDINESTPLAYAL 306
G+ V +LL+ G D N + + TPL A+
Sbjct: 635 RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667
Score = 60.1 bits (144), Expect = 6e-09
Identities = 46/158 (29%), Positives = 67/158 (42%), Gaps = 4/158 (2%)
Query: 163 MTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPS 222
+TPLH+ + ++LL D T L A Q LC+++L+H +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 223 IINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQ 282
+ DE G +H AA G L C + A + + TPLH AA +
Sbjct: 423 RV---DEDGWAPLHFAAQNGDDGTARLLLDHGAC-VDAQEREGWTPLHLAAQNNFENVAR 478
Query: 283 SLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQE 320
L+ D NL + TPL A Y GH + VKLL+ +
Sbjct: 479 LLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQ 516
Score = 32.7 bits (73), Expect = 1.0
Identities = 33/123 (26%), Positives = 57/123 (46%), Gaps = 5/123 (4%)
Query: 26 VDLTMVYQAASNGDVNALTAVIR--EDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKM 83
V+ T ++ AA +G+ ++A+++ DP+ E G TPL AV +V LL+
Sbjct: 625 VNWTPLHLAARHGEEAVVSALLQCGADPNAAE---QSGWTPLHLAVQRSTFLSVINLLEH 681
Query: 84 GANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLL 143
AN++ ++ G T LA G L+ GA+ ++ D PL A ++
Sbjct: 682 HANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM 741
Query: 144 TVL 146
+ L
Sbjct: 742 SFL 744
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 105 bits (262), Expect = 1e-22
Identities = 85/292 (29%), Positives = 137/292 (46%), Gaps = 12/292 (4%)
Query: 17 QQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADT 76
Q+ GD +EE+ +AA+NGDV + +++ P + G T + A D
Sbjct: 426 QESGDLNEEL-----VKAAANGDVAKVEDLLKR-PDVDVNGQCAGHTAMQAASQNGHVDI 479
Query: 77 VKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVS--LLRNGAKHNIPDKNGRLPLHAA 134
+KLLLK ++ +D G ++ A + EG V L R A N +K + PLH A
Sbjct: 480 LKLLLKQNVDVEAEDKDGDRAVHHAAFGD--EGAVIEVLHRGSADLNARNKRRQTPLHIA 537
Query: 135 TAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKD 194
+ ++++ LL + QD+EG TPLH A + +LL+ GAD T+ + +
Sbjct: 538 VNKGHLQVVKTLLDFGCHPSL--QDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNN 595
Query: 195 FKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVP 254
ALH A GN ++LS P I++ + G T +H+AA ++ L
Sbjct: 596 GFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQG 655
Query: 255 ECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYAL 306
NL +V+ +T LH A + V+ L+ G +++D + TPL AL
Sbjct: 656 NANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEAL 707
Score = 57.8 bits (138), Expect = 3e-08
Identities = 45/150 (30%), Positives = 74/150 (49%), Gaps = 4/150 (2%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
DSEG TPL A+S ++ D + +LL+ GA++ + + G +L A G LL
Sbjct: 560 DSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKL 619
Query: 118 AKHNIPDK---NGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQ 174
+ I D+ +G LH A + + +L+ Q N + ++ Q+ T LH A
Sbjct: 620 PRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGN-ANLDIQNVNQQTALHLAVERQH 678
Query: 175 PQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
Q ++L++ GA + DKD T LH A++
Sbjct: 679 TQIVRLLVRAGAKLDIQDKDGDTPLHEALR 708
Score = 54.3 bits (129), Expect = 3e-07
Identities = 46/184 (25%), Positives = 87/184 (47%), Gaps = 6/184 (3%)
Query: 134 ATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDK 193
A A D+ + LL++ ++ ++N Q G T + A+ + ++LLK+ D DK
Sbjct: 438 AAANGDVAKVEDLLKRPDV-DVNGQC-AGHTAMQAASQNGHVDILKLLLKQNVDVEAEDK 495
Query: 194 DFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARV 253
D A+H A + ++ H+G + +N ++ +T +HIA G ++ L
Sbjct: 496 DGDRAVHHAAFGDEGAVIEVL---HRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDF 552
Query: 254 PECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTAC 313
C+ D + TPLH A + + + + LLE G D + + N L +A G+ +
Sbjct: 553 G-CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSA 611
Query: 314 VKLL 317
+++L
Sbjct: 612 MRVL 615
Score = 46.6 bits (109), Expect = 7e-05
Identities = 35/129 (27%), Positives = 65/129 (50%), Gaps = 3/129 (2%)
Query: 31 VYQAASNGDVNALTAVIREDPS--ILECCDSEGCTPLMHAVSGRQADTVKLLLKMG-ANI 87
++ AA G+ +A+ ++ + P I++ +G T L A + +LL+ G AN+
Sbjct: 600 LHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANL 659
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
++Q+ +T+L LA + L+R GAK +I DK+G PLH A + L L
Sbjct: 660 DIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQ 719
Query: 148 QQSNISEIN 156
++ +++
Sbjct: 720 DMQDVGKVD 728
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 103 bits (256), Expect = 6e-22
Identities = 90/326 (27%), Positives = 141/326 (43%), Gaps = 18/326 (5%)
Query: 5 ATMDFSTPSVFDQQRGDSSE-----------EVDLTMVYQAASNGDVNALTAVIREDPSI 53
AT D TP Q+G + +V L ++ AA N D +++ DP+
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
+ G TPL A + +LLL GA++N G T L +A+ G + L
Sbjct: 233 -DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L GA+ K+ PLH A +R+ +LL + I + G++P+H AA +
Sbjct: 292 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG--APIQAKTKNGLSPIHMAAQGD 349
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT 233
++LL+ A+ + D T LH A G+ + ++L P N +G T
Sbjct: 350 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGFT 406
Query: 234 CVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+HIA ++ EL ++ A+ TPLH A+ G V++LL+ G N+
Sbjct: 407 PLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465
Query: 294 RDINESTPLAYALYCGHTACVKLLSQ 319
++ TPL A GHT K L Q
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQ 491
Score = 102 bits (255), Expect = 8e-22
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 7/291 (2%)
Query: 27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
+LT ++ AA NG V ++ ++ + + ++ G +P+ A G D V+LLL+ A
Sbjct: 305 ELTPLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
I+ T L +A + G LL GAK N NG PLH A + +R++ +L
Sbjct: 364 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 423
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ + I+ G+TPLH A+F + LL++GA P + + +T LH A ++G
Sbjct: 424 LKTG--ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 481
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
+ + +L Q + +N + +T +H AA G ++++ +L N
Sbjct: 482 HTEVAKYLL---QNKAKVNAKAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGH 537
Query: 267 TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
TPLH AA G E V +LLE TPL A G +LL
Sbjct: 538 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588
Score = 101 bits (251), Expect = 2e-21
Identities = 91/319 (28%), Positives = 136/319 (42%), Gaps = 36/319 (11%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ A+ G V + ++ ++ ILE +G T L A Q + V+ L+ GAN+
Sbjct: 79 LNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 137
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A LE LL NGA N+ ++G
Sbjct: 138 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 197
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
RLP LH A D R VLLQ ++ G TPLH AA +
Sbjct: 198 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV--LSKTGFTPLHIAAHYENLNVA 255
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIA 238
Q+LL +GA ++ T LH A + GN I+ ++L + I + T +H A
Sbjct: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQIETKTKDELTPLHCA 312
Query: 239 AAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINE 298
A G I E+ +QA + +P+H AA +CV+ LL+ + + ++
Sbjct: 313 ARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 299 STPLAYALYCGHTACVKLL 317
TPL A +CGH K+L
Sbjct: 372 LTPLHVAAHCGHHRVAKVL 390
Score = 97.8 bits (242), Expect = 3e-20
Identities = 81/289 (28%), Positives = 132/289 (45%), Gaps = 7/289 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G V + A++ ++ S C +G TPL A + +LLL+ A+ N
Sbjct: 538 TPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 596
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A + L+ LL G + P NG PLH A + + + LLQ
Sbjct: 597 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 656
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
N + +G+TPLH AA + +LL K A+ L +K T LH Q G+
Sbjct: 657 YG--GSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 714
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +++ H +++ G T +H+A+ G ++ L + + ++ A +P
Sbjct: 715 PVADVLIKH---GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAKTKLGYSP 770
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA G + V LL+ G N + +TPLA A G+ + +L
Sbjct: 771 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 90.5 bits (223), Expect = 4e-18
Identities = 81/289 (28%), Positives = 121/289 (41%), Gaps = 37/289 (12%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A ++LLLK GA+I+ G T L +A+++G L +LL+ GA
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N+ + PLH A + LLQ N +++N + + TPLH AA ++
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 521
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA- 239
LL+ A+P L T LH A + G+ +L + + + G T +H+AA
Sbjct: 522 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAK 578
Query: 240 ------------------AAGFSDIIHELARVPECNLQALDV-------------DDRTP 268
AAG + + V NL + + + TP
Sbjct: 579 YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 638
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + E +SLL+ G +N + TPL A GH V LL
Sbjct: 639 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Score = 72.8 bits (177), Expect = 9e-13
Identities = 55/195 (28%), Positives = 89/195 (45%), Gaps = 5/195 (2%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A Q + + LL+ G + N + G T L LA G E LL A
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N+ +K+G PLH E + + VL++ + ++ G TPLH A+ + + +
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVM--VDATTRMGYTPLHVASHYGNIKLVKF 752
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAA 240
LL+ AD K + LH A Q G+ + +++L + P+ ++ D G T + IA
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD---GTTPLAIAKR 809
Query: 241 AGFSDIIHELARVPE 255
G+ + L V +
Sbjct: 810 LGYISVTDVLKVVTD 824
Score = 68.6 bits (166), Expect = 2e-11
Identities = 73/262 (27%), Positives = 108/262 (41%), Gaps = 16/262 (6%)
Query: 59 SEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGA 118
++ T + A D L+ G +IN + G L LA+ G ++ V LL
Sbjct: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEI 102
Query: 119 KHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
K G LH A ++ L+ + +N Q +G TPL+ AA N +
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYG--ANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT---CV 235
+ LL+ GA+ + +D T L A+Q G+ +++H +INY + GK +
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGH----ENVVAH-----LINYGTK-GKVRLPAL 210
Query: 236 HIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRD 295
HIAA + L + + N L TPLH AA Q LL G N
Sbjct: 211 HIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 269
Query: 296 INESTPLAYALYCGHTACVKLL 317
N TPL A G+ V+LL
Sbjct: 270 QNGITPLHIASRRGNVIMVRLL 291
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 4/131 (3%)
Query: 194 DFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARV 253
D T+ A +SGN L H + IN +++G +H+A+ G ++ EL
Sbjct: 44 DAATSFLRAARSGN---LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH- 99
Query: 254 PECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTAC 313
E L+ T LH AA AG+ E V+ L+ G + N + TPL A H
Sbjct: 100 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 159
Query: 314 VKLLSQESRTE 324
VK L + +
Sbjct: 160 VKFLLENGANQ 170
Score = 30.0 bits (66), Expect = 6.5
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 356 EEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIV-GTNCQEQPGDQVAMVEF 406
E+ A RDR ++ +V + TF +V G Q PG+QV +F
Sbjct: 1805 EQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQF 1856
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 103 bits (256), Expect = 6e-22
Identities = 90/326 (27%), Positives = 141/326 (43%), Gaps = 18/326 (5%)
Query: 5 ATMDFSTPSVFDQQRGDSSE-----------EVDLTMVYQAASNGDVNALTAVIREDPSI 53
AT D TP Q+G + +V L ++ AA N D +++ DP+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
+ G TPL A + +LLL GA++N G T L +A+ G + L
Sbjct: 200 -DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L GA+ K+ PLH A +R+ +LL + I + G++P+H AA +
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG--APIQAKTKNGLSPIHMAAQGD 316
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT 233
++LL+ A+ + D T LH A G+ + ++L P N +G T
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGFT 373
Query: 234 CVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+HIA ++ EL ++ A+ TPLH A+ G V++LL+ G N+
Sbjct: 374 PLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 294 RDINESTPLAYALYCGHTACVKLLSQ 319
++ TPL A GHT K L Q
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 102 bits (255), Expect = 8e-22
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 7/291 (2%)
Query: 27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
+LT ++ AA NG V ++ ++ + + ++ G +P+ A G D V+LLL+ A
Sbjct: 272 ELTPLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
I+ T L +A + G LL GAK N NG PLH A + +R++ +L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ + I+ G+TPLH A+F + LL++GA P + + +T LH A ++G
Sbjct: 391 LKTG--ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
+ + +L Q + +N + +T +H AA G ++++ +L N
Sbjct: 449 HTEVAKYLL---QNKAKVNAKAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGH 504
Query: 267 TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
TPLH AA G E V +LLE TPL A G +LL
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 91/319 (28%), Positives = 136/319 (42%), Gaps = 36/319 (11%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ A+ G V + ++ ++ ILE +G T L A Q + V+ L+ GAN+
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A LE LL NGA N+ ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
RLP LH A D R VLLQ ++ G TPLH AA +
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV--LSKTGFTPLHIAAHYENLNVA 222
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIA 238
Q+LL +GA ++ T LH A + GN I+ ++L + I + T +H A
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQIETKTKDELTPLHCA 279
Query: 239 AAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINE 298
A G I E+ +QA + +P+H AA +CV+ LL+ + + ++
Sbjct: 280 ARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 299 STPLAYALYCGHTACVKLL 317
TPL A +CGH K+L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/361 (26%), Positives = 156/361 (43%), Gaps = 11/361 (3%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G V + A++ ++ S C +G TPL A + +LLL+ A+ N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A + L+ LL G + P NG PLH A + + + LLQ
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
N + +G+TPLH AA + +LL K A+ L +K T LH Q G+
Sbjct: 624 YG--GSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +++ H +++ G T +H+A+ G ++ L + + ++ A +P
Sbjct: 682 PVADVLIKH---GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAKTKLGYSP 737
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRP 328
LH AA G + V LL+ G N + +TPLA A G+ + +L + E +
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVT-DETSFV 796
Query: 329 PPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSI 388
S R E +L+ + E+ K RD ++ E+ D + D +
Sbjct: 797 LVSDKHRMSFPETVDEILD---VSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQV 853
Query: 389 V 389
V
Sbjct: 854 V 854
Score = 90.5 bits (223), Expect = 4e-18
Identities = 81/289 (28%), Positives = 121/289 (41%), Gaps = 37/289 (12%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A ++LLLK GA+I+ G T L +A+++G L +LL+ GA
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N+ + PLH A + LLQ N +++N + + TPLH AA ++
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA- 239
LL+ A+P L T LH A + G+ +L + + + G T +H+AA
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAK 545
Query: 240 ------------------AAGFSDIIHELARVPECNLQALDV-------------DDRTP 268
AAG + + V NL + + + TP
Sbjct: 546 YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + E +SLL+ G +N + TPL A GH V LL
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/263 (27%), Positives = 109/263 (41%), Gaps = 16/263 (6%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
+++ T + A D L+ G +IN + G L LA+ G ++ V LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
K G LH A ++ L+ + +N Q +G TPL+ AA N +
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYG--ANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 178 TQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT---C 234
+ LL+ GA+ + +D T L A+Q G+ +++H +INY + GK
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGH----ENVVAH-----LINYGTK-GKVRLPA 176
Query: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
+HIAA + L + + N L TPLH AA Q LL G N
Sbjct: 177 LHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 295 DINESTPLAYALYCGHTACVKLL 317
N TPL A G+ V+LL
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLL 258
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 4/133 (3%)
Query: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELA 251
+ D T+ A +SGN L H + IN +++G +H+A+ G ++ EL
Sbjct: 9 EADAATSFLRAARSGN---LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 252 RVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHT 311
E L+ T LH AA AG+ E V+ L+ G + N + TPL A H
Sbjct: 66 H-KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 312 ACVKLLSQESRTE 324
VK L + +
Sbjct: 125 EVVKFLLENGANQ 137
Score = 30.0 bits (66), Expect = 6.5
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 356 EEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIV-GTNCQEQPGDQVAMVEF 406
E+ A RDR ++ +V + TF +V G Q PG+QV +F
Sbjct: 1764 EQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQF 1815
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 103 bits (256), Expect = 6e-22
Identities = 90/326 (27%), Positives = 141/326 (43%), Gaps = 18/326 (5%)
Query: 5 ATMDFSTPSVFDQQRGDSSE-----------EVDLTMVYQAASNGDVNALTAVIREDPSI 53
AT D TP Q+G + +V L ++ AA N D +++ DP+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
+ G TPL A + +LLL GA++N G T L +A+ G + L
Sbjct: 200 -DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L GA+ K+ PLH A +R+ +LL + I + G++P+H AA +
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG--APIQAKTKNGLSPIHMAAQGD 316
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT 233
++LL+ A+ + D T LH A G+ + ++L P N +G T
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGFT 373
Query: 234 CVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+HIA ++ EL ++ A+ TPLH A+ G V++LL+ G N+
Sbjct: 374 PLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 294 RDINESTPLAYALYCGHTACVKLLSQ 319
++ TPL A GHT K L Q
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 102 bits (255), Expect = 8e-22
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 7/291 (2%)
Query: 27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
+LT ++ AA NG V ++ ++ + + ++ G +P+ A G D V+LLL+ A
Sbjct: 272 ELTPLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
I+ T L +A + G LL GAK N NG PLH A + +R++ +L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ + I+ G+TPLH A+F + LL++GA P + + +T LH A ++G
Sbjct: 391 LKTG--ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
+ + +L Q + +N + +T +H AA G ++++ +L N
Sbjct: 449 HTEVAKYLL---QNKAKVNAKAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGH 504
Query: 267 TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
TPLH AA G E V +LLE TPL A G +LL
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 91/319 (28%), Positives = 136/319 (42%), Gaps = 36/319 (11%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ A+ G V + ++ ++ ILE +G T L A Q + V+ L+ GAN+
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A LE LL NGA N+ ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
RLP LH A D R VLLQ ++ G TPLH AA +
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV--LSKTGFTPLHIAAHYENLNVA 222
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIA 238
Q+LL +GA ++ T LH A + GN I+ ++L + I + T +H A
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQIETKTKDELTPLHCA 279
Query: 239 AAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINE 298
A G I E+ +QA + +P+H AA +CV+ LL+ + + ++
Sbjct: 280 ARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 299 STPLAYALYCGHTACVKLL 317
TPL A +CGH K+L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/361 (26%), Positives = 156/361 (43%), Gaps = 11/361 (3%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G V + A++ ++ S C +G TPL A + +LLL+ A+ N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A + L+ LL G + P NG PLH A + + + LLQ
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
N + +G+TPLH AA + +LL K A+ L +K T LH Q G+
Sbjct: 624 YG--GSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +++ H +++ G T +H+A+ G ++ L + + ++ A +P
Sbjct: 682 PVADVLIKH---GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAKTKLGYSP 737
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRP 328
LH AA G + V LL+ G N + +TPLA A G+ + +L + E +
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVT-DETSFV 796
Query: 329 PPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSI 388
S R E +L+ + E+ K RD ++ E+ D + D +
Sbjct: 797 LVSDKHRMSFPETVDEILD---VSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQV 853
Query: 389 V 389
V
Sbjct: 854 V 854
Score = 90.5 bits (223), Expect = 4e-18
Identities = 81/289 (28%), Positives = 121/289 (41%), Gaps = 37/289 (12%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A ++LLLK GA+I+ G T L +A+++G L +LL+ GA
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N+ + PLH A + LLQ N +++N + + TPLH AA ++
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA- 239
LL+ A+P L T LH A + G+ +L + + + G T +H+AA
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAK 545
Query: 240 ------------------AAGFSDIIHELARVPECNLQALDV-------------DDRTP 268
AAG + + V NL + + + TP
Sbjct: 546 YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + E +SLL+ G +N + TPL A GH V LL
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/263 (27%), Positives = 109/263 (41%), Gaps = 16/263 (6%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
+++ T + A D L+ G +IN + G L LA+ G ++ V LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
K G LH A ++ L+ + +N Q +G TPL+ AA N +
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYG--ANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 178 TQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT---C 234
+ LL+ GA+ + +D T L A+Q G+ +++H +INY + GK
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGH----ENVVAH-----LINYGTK-GKVRLPA 176
Query: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
+HIAA + L + + N L TPLH AA Q LL G N
Sbjct: 177 LHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 295 DINESTPLAYALYCGHTACVKLL 317
N TPL A G+ V+LL
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLL 258
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 4/133 (3%)
Query: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELA 251
+ D T+ A +SGN L H + IN +++G +H+A+ G ++ EL
Sbjct: 9 EADAATSFLRAARSGN---LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 252 RVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHT 311
E L+ T LH AA AG+ E V+ L+ G + N + TPL A H
Sbjct: 66 H-KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 312 ACVKLLSQESRTE 324
VK L + +
Sbjct: 125 EVVKFLLENGANQ 137
Score = 30.0 bits (66), Expect = 6.5
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 356 EEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIV-GTNCQEQPGDQVAMVEF 406
E+ A RDR ++ +V + TF +V G Q PG+QV +F
Sbjct: 1764 EQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQF 1815
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 103 bits (256), Expect = 6e-22
Identities = 90/326 (27%), Positives = 141/326 (43%), Gaps = 18/326 (5%)
Query: 5 ATMDFSTPSVFDQQRGDSSE-----------EVDLTMVYQAASNGDVNALTAVIREDPSI 53
AT D TP Q+G + +V L ++ AA N D +++ DP+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
+ G TPL A + +LLL GA++N G T L +A+ G + L
Sbjct: 200 -DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L GA+ K+ PLH A +R+ +LL + I + G++P+H AA +
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG--APIQAKTKNGLSPIHMAAQGD 316
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT 233
++LL+ A+ + D T LH A G+ + ++L P N +G T
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGFT 373
Query: 234 CVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+HIA ++ EL ++ A+ TPLH A+ G V++LL+ G N+
Sbjct: 374 PLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 294 RDINESTPLAYALYCGHTACVKLLSQ 319
++ TPL A GHT K L Q
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 102 bits (255), Expect = 8e-22
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 7/291 (2%)
Query: 27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
+LT ++ AA NG V ++ ++ + + ++ G +P+ A G D V+LLL+ A
Sbjct: 272 ELTPLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
I+ T L +A + G LL GAK N NG PLH A + +R++ +L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ + I+ G+TPLH A+F + LL++GA P + + +T LH A ++G
Sbjct: 391 LKTG--ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
+ + +L Q + +N + +T +H AA G ++++ +L N
Sbjct: 449 HTEVAKYLL---QNKAKVNAKAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGH 504
Query: 267 TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
TPLH AA G E V +LLE TPL A G +LL
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 91/319 (28%), Positives = 136/319 (42%), Gaps = 36/319 (11%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ A+ G V + ++ ++ ILE +G T L A Q + V+ L+ GAN+
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A LE LL NGA N+ ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
RLP LH A D R VLLQ ++ G TPLH AA +
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV--LSKTGFTPLHIAAHYENLNVA 222
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIA 238
Q+LL +GA ++ T LH A + GN I+ ++L + I + T +H A
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQIETKTKDELTPLHCA 279
Query: 239 AAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINE 298
A G I E+ +QA + +P+H AA +CV+ LL+ + + ++
Sbjct: 280 ARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 299 STPLAYALYCGHTACVKLL 317
TPL A +CGH K+L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/361 (26%), Positives = 156/361 (43%), Gaps = 11/361 (3%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G V + A++ ++ S C +G TPL A + +LLL+ A+ N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A + L+ LL G + P NG PLH A + + + LLQ
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
N + +G+TPLH AA + +LL K A+ L +K T LH Q G+
Sbjct: 624 YG--GSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +++ H +++ G T +H+A+ G ++ L + + ++ A +P
Sbjct: 682 PVADVLIKH---GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAKTKLGYSP 737
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRP 328
LH AA G + V LL+ G N + +TPLA A G+ + +L + E +
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVT-DETSFV 796
Query: 329 PPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSI 388
S R E +L+ + E+ K RD ++ E+ D + D +
Sbjct: 797 LVSDKHRMSFPETVDEILD---VSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQV 853
Query: 389 V 389
V
Sbjct: 854 V 854
Score = 90.5 bits (223), Expect = 4e-18
Identities = 81/289 (28%), Positives = 121/289 (41%), Gaps = 37/289 (12%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A ++LLLK GA+I+ G T L +A+++G L +LL+ GA
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N+ + PLH A + LLQ N +++N + + TPLH AA ++
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA- 239
LL+ A+P L T LH A + G+ +L + + + G T +H+AA
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAK 545
Query: 240 ------------------AAGFSDIIHELARVPECNLQALDV-------------DDRTP 268
AAG + + V NL + + + TP
Sbjct: 546 YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + E +SLL+ G +N + TPL A GH V LL
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/263 (27%), Positives = 109/263 (41%), Gaps = 16/263 (6%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
+++ T + A D L+ G +IN + G L LA+ G ++ V LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
K G LH A ++ L+ + +N Q +G TPL+ AA N +
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYG--ANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 178 TQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT---C 234
+ LL+ GA+ + +D T L A+Q G+ +++H +INY + GK
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGH----ENVVAH-----LINYGTK-GKVRLPA 176
Query: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
+HIAA + L + + N L TPLH AA Q LL G N
Sbjct: 177 LHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 295 DINESTPLAYALYCGHTACVKLL 317
N TPL A G+ V+LL
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLL 258
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 4/133 (3%)
Query: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELA 251
+ D T+ A +SGN L H + IN +++G +H+A+ G ++ EL
Sbjct: 9 EADAATSFLRAARSGN---LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 252 RVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHT 311
E L+ T LH AA AG+ E V+ L+ G + N + TPL A H
Sbjct: 66 H-KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 312 ACVKLLSQESRTE 324
VK L + +
Sbjct: 125 EVVKFLLENGANQ 137
Score = 30.0 bits (66), Expect = 6.5
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 356 EEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIV-GTNCQEQPGDQVAMVEF 406
E+ A RDR ++ +V + TF +V G Q PG+QV +F
Sbjct: 1602 EQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQF 1653
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 103 bits (256), Expect = 6e-22
Identities = 90/326 (27%), Positives = 141/326 (43%), Gaps = 18/326 (5%)
Query: 5 ATMDFSTPSVFDQQRGDSSE-----------EVDLTMVYQAASNGDVNALTAVIREDPSI 53
AT D TP Q+G + +V L ++ AA N D +++ DP+
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
+ G TPL A + +LLL GA++N G T L +A+ G + L
Sbjct: 200 -DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L GA+ K+ PLH A +R+ +LL + I + G++P+H AA +
Sbjct: 259 LDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG--APIQAKTKNGLSPIHMAAQGD 316
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT 233
++LL+ A+ + D T LH A G+ + ++L P N +G T
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP---NSRALNGFT 373
Query: 234 CVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+HIA ++ EL ++ A+ TPLH A+ G V++LL+ G N+
Sbjct: 374 PLHIACKKNHVRVM-ELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432
Query: 294 RDINESTPLAYALYCGHTACVKLLSQ 319
++ TPL A GHT K L Q
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQ 458
Score = 102 bits (255), Expect = 8e-22
Identities = 84/291 (28%), Positives = 135/291 (46%), Gaps = 7/291 (2%)
Query: 27 DLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGAN 86
+LT ++ AA NG V ++ ++ + + ++ G +P+ A G D V+LLL+ A
Sbjct: 272 ELTPLHCAARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 87 INMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVL 146
I+ T L +A + G LL GAK N NG PLH A + +R++ +L
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSG 206
L+ + I+ G+TPLH A+F + LL++GA P + + +T LH A ++G
Sbjct: 391 LKTG--ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAG 448
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDR 266
+ + +L Q + +N + +T +H AA G ++++ +L N
Sbjct: 449 HTEVAKYLL---QNKAKVNAKAKDDQTPLHCAARIGHTNMV-KLLLENNANPNLATTAGH 504
Query: 267 TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
TPLH AA G E V +LLE TPL A G +LL
Sbjct: 505 TPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 101 bits (251), Expect = 2e-21
Identities = 91/319 (28%), Positives = 136/319 (42%), Gaps = 36/319 (11%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ A+ G V + ++ ++ ILE +G T L A Q + V+ L+ GAN+
Sbjct: 46 LNGLHLASKEGHVKMVVELLHKE-IILETTTKKGNTALHIAALAGQDEVVRELVNYGANV 104
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A LE LL NGA N+ ++G
Sbjct: 105 NAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLI 164
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
RLP LH A D R VLLQ ++ G TPLH AA +
Sbjct: 165 NYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDV--LSKTGFTPLHIAAHYENLNVA 222
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIA 238
Q+LL +GA ++ T LH A + GN I+ ++L + I + T +H A
Sbjct: 223 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR---GAQIETKTKDELTPLHCA 279
Query: 239 AAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINE 298
A G I E+ +QA + +P+H AA +CV+ LL+ + + ++
Sbjct: 280 ARNGHVR-ISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 299 STPLAYALYCGHTACVKLL 317
TPL A +CGH K+L
Sbjct: 339 LTPLHVAAHCGHHRVAKVL 357
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/361 (26%), Positives = 156/361 (43%), Gaps = 11/361 (3%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G V + A++ ++ S C +G TPL A + +LLL+ A+ N
Sbjct: 505 TPLHIAAREGHVETVLALLEKEAS-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN 563
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A + L+ LL G + P NG PLH A + + + LLQ
Sbjct: 564 AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQ 623
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
N + +G+TPLH AA + +LL K A+ L +K T LH Q G+
Sbjct: 624 YG--GSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHV 681
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +++ H +++ G T +H+A+ G ++ L + + ++ A +P
Sbjct: 682 PVADVLIKH---GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ-HQADVNAKTKLGYSP 737
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRP 328
LH AA G + V LL+ G N + +TPLA A G+ + +L + E +
Sbjct: 738 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVT-DETSFV 796
Query: 329 PPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSI 388
S R E +L+ + E+ K RD ++ E+ D + D +
Sbjct: 797 LVSDKHRMSFPETVDEILD---VSEDEGEELISFKAERRDSRDVDEEKELLDFVPKLDQV 853
Query: 389 V 389
V
Sbjct: 854 V 854
Score = 90.5 bits (223), Expect = 4e-18
Identities = 81/289 (28%), Positives = 121/289 (41%), Gaps = 37/289 (12%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A ++LLLK GA+I+ G T L +A+++G L +LL+ GA
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N+ + PLH A + LLQ N +++N + + TPLH AA ++
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQ--NKAKVNAKAKDDQTPLHCAARIGHTNMVKL 488
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA- 239
LL+ A+P L T LH A + G+ +L + + + G T +H+AA
Sbjct: 489 LLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT---KKGFTPLHVAAK 545
Query: 240 ------------------AAGFSDIIHELARVPECNLQALDV-------------DDRTP 268
AAG + + V NL + + + TP
Sbjct: 546 YGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTP 605
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + E +SLL+ G +N + TPL A GH V LL
Sbjct: 606 LHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 69.3 bits (168), Expect = 1e-11
Identities = 73/263 (27%), Positives = 109/263 (41%), Gaps = 16/263 (6%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNG 117
+++ T + A D L+ G +IN + G L LA+ G ++ V LL
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68
Query: 118 AKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQH 177
K G LH A ++ L+ + +N Q +G TPL+ AA N +
Sbjct: 69 IILETTTKKGNTALHIAALAGQDEVVRELVNYG--ANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 178 TQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT---C 234
+ LL+ GA+ + +D T L A+Q G+ +++H +INY + GK
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGH----ENVVAH-----LINYGTK-GKVRLPA 176
Query: 235 VHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLR 294
+HIAA + L + + N L TPLH AA Q LL G N
Sbjct: 177 LHIAARNDDTRTAAVLLQ-NDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235
Query: 295 DINESTPLAYALYCGHTACVKLL 317
N TPL A G+ V+LL
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLL 258
Score = 45.8 bits (107), Expect = 1e-04
Identities = 38/133 (28%), Positives = 58/133 (43%), Gaps = 4/133 (3%)
Query: 192 DKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELA 251
+ D T+ A +SGN L H + IN +++G +H+A+ G ++ EL
Sbjct: 9 EADAATSFLRAARSGN---LDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELL 65
Query: 252 RVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHT 311
E L+ T LH AA AG+ E V+ L+ G + N + TPL A H
Sbjct: 66 H-KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 124
Query: 312 ACVKLLSQESRTE 324
VK L + +
Sbjct: 125 EVVKFLLENGANQ 137
Score = 30.0 bits (66), Expect = 6.5
Identities = 16/52 (30%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 356 EEQRAHQKDPSRDRYREEDTSEVNDIITTFDSIV-GTNCQEQPGDQVAMVEF 406
E+ A RDR ++ +V + TF +V G Q PG+QV +F
Sbjct: 1764 EQPEAESSQADRDRRQQGQEEQVQEAKNTFTQVVQGNEFQNIPGEQVTEEQF 1815
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 103 bits (256), Expect = 6e-22
Identities = 81/249 (32%), Positives = 120/249 (48%), Gaps = 7/249 (2%)
Query: 69 VSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 128
VSG + +K+L ++ + G + L LA G E LL N A N+ ++ G
Sbjct: 415 VSGDTSKLMKILQPQDVDLALDS--GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGS 472
Query: 129 LPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADP 188
PLH A E +R + LL IS +N +D + T LH+AA + T++LL+K A
Sbjct: 473 TPLHMAV-ERRVRGVVELLLARKIS-VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV 530
Query: 189 TLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIH 248
VD + +T +H A Q G + I+L S+ D +H AA G I+
Sbjct: 531 NEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKD---AWLPLHYAAWQGHLPIVK 587
Query: 249 ELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYC 308
LA+ P ++ A +D RTPLH AA G + L++L D N+ + TPL A
Sbjct: 588 LLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAET 647
Query: 309 GHTACVKLL 317
GHT+ +LL
Sbjct: 648 GHTSTARLL 656
Score = 100 bits (248), Expect = 5e-21
Identities = 93/315 (29%), Positives = 141/315 (44%), Gaps = 17/315 (5%)
Query: 25 EVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMG 84
+V + A +GD + L +++ P ++ G + L AV Q + K LL
Sbjct: 404 DVQKKKLVDAIVSGDTSKLMKILQ--PQDVDLALDSGASLLHLAVEAGQEECAKWLLLNN 461
Query: 85 ANINMQDAYGRTSLCLATYLGWLEGCVSLL-RNGAKHNIPDKNGRLPLHAATAEPDMRLL 143
AN N+ + G T L +A + G V LL N D++ LH A D
Sbjct: 462 ANPNLSNRRGSTPLHMAVERR-VRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESST 520
Query: 144 TVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAV 203
+LL+++ + +N D EG TP+H A H Q ++LL++G D +L KD LH+A
Sbjct: 521 RLLLEKN--ASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAA 578
Query: 204 QSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL----ARVPECNLQ 259
G+ + + L+ G S+ N G+T +H+AA G + L + V C+L
Sbjct: 579 WQGHLPIVKL-LAKQPGVSV-NAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLL 636
Query: 260 ALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
A +TPLH AA G + LL G + T L A GH A VKLL +
Sbjct: 637 A-----QTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVE 691
Query: 320 ESRTEPTRPPPSQSS 334
E R P +Q++
Sbjct: 692 EKADVLARGPLNQTA 706
Score = 98.2 bits (243), Expect = 2e-20
Identities = 81/283 (28%), Positives = 133/283 (46%), Gaps = 21/283 (7%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
++ +E T ++ AA NGD ++ ++ ++ S+ E D EG TP+ A Q + V++L
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEV-DFEGRTPMHVACQHGQENIVRIL 556
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRN--GAKHNIPDKNGRLPLHAATAEP 138
L+ G ++++Q L A + G L V LL G N +GR PLH A
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLP-IVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
Query: 139 DMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTA 198
R+ +L+ S++N TPLH AA ++LL +GA + D TA
Sbjct: 616 HYRVARILIDLC--SDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTA 673
Query: 199 LHWAVQSGNRILCSIILSHH-----QGPSIINYDDESGKTCVHIAAAAGFSDIIHELARV 253
LH A ++G+ +++ +GP +T +H+AAA G S+++ EL
Sbjct: 674 LHLAARNGHLATVKLLVEEKADVLARGPL--------NQTALHLAAAHGHSEVVEELVSA 725
Query: 254 PECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDI 296
+L D + LH AA A+ V++LL G NL+ +
Sbjct: 726 DVIDL--FDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSL 766
Score = 78.2 bits (191), Expect = 2e-14
Identities = 74/258 (28%), Positives = 110/258 (42%), Gaps = 7/258 (2%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL AV R V+LLL ++N +D T+L A G LL A
Sbjct: 471 GSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV 530
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N D GR P+H A ++ +LL++ +++ Q + PLH+AA+ ++
Sbjct: 531 NEVDFEGRTPMHVACQHGQENIVRILLRRG--VDVSLQGKDAWLPLHYAAWQGHLPIVKL 588
Query: 181 LLKK-GADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAA 239
L K+ G D +T LH A Q G+ + I++ S +N +T +H+AA
Sbjct: 589 LAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL---CSDVNVCSLLAQTPLHVAA 645
Query: 240 AAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINES 299
G + L +A+ D T LH AA G V+ L+E D R
Sbjct: 646 ETGHTSTARLLLH-RGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQ 704
Query: 300 TPLAYALYCGHTACVKLL 317
T L A GH+ V+ L
Sbjct: 705 TALHLAAAHGHSEVVEEL 722
Score = 32.0 bits (71), Expect = 1.7
Identities = 43/175 (24%), Positives = 69/175 (39%), Gaps = 20/175 (11%)
Query: 6 TMDFSTPSVFDQQRG---------DSSEEVDL------TMVYQAASNGDVNALTAVIRED 50
T+D TP QRG D +V++ T ++ AA G + ++
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660
Query: 51 PSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGC 110
E S+G T L A TVKLL++ A++ + +T+L LA G E
Sbjct: 661 AG-KEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSE-V 718
Query: 111 VSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQS---NISEINHQDNEG 162
V L + ++ D+ G LH A + + LL+ N+ + Q G
Sbjct: 719 VEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHG 773
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 102 bits (254), Expect = 1e-21
Identities = 82/295 (27%), Positives = 133/295 (45%), Gaps = 19/295 (6%)
Query: 52 SILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCV 111
++L C +G P++ + D ++ D GRT+ A G L+
Sbjct: 126 TLLHCAAQKGHVPVLAFIMEDLEDVA---------LDHVDKLGRTAFHRAAEHGQLDALD 176
Query: 112 SLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAF 171
L+ +G HN+ DK G LH A M +L L+ ++ Q+ EG+T LH AA
Sbjct: 177 FLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG--LDLEEQNAEGLTALHSAAG 234
Query: 172 HNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESG 231
+ P Q+LL+ G+ + + + LH+A SG+ + +++ H G N D G
Sbjct: 235 GSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLI--HAG-GCANVVDHQG 291
Query: 232 KTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDS 291
+ +H+A F ++ L + ++ A+D +TPLH AA + LL G+D
Sbjct: 292 ASPLHLAVRHNFPALVRLLIN-SDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDL 350
Query: 292 NLRDINESTPLAYALYCGHTACVKLLSQES---RTEPTRP-PPSQSSRPQKKERR 342
NLRD T LA A+ H + V ++ + R E P PS S K++ R
Sbjct: 351 NLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHR 405
Score = 87.4 bits (215), Expect = 3e-17
Identities = 71/267 (26%), Positives = 117/267 (43%), Gaps = 14/267 (5%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDA----------YGRTSLCLATYLGWLEGC 110
G L A V+LLL+ A ++ +DA +G +L L+ + G L
Sbjct: 48 GRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRIL 107
Query: 111 VSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAA 170
L+ +GAK + K+G LH A + + +L +++ ++H D G T H AA
Sbjct: 108 QILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAA 167
Query: 171 FHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDES 230
H Q L+ G D + DK+ TALH A G+ + ++ + +
Sbjct: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLD---LEEQNAE 224
Query: 231 GKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMD 290
G T +H AA D + L R + AL + + LH+AA +G + + L+ G
Sbjct: 225 GLTALHSAAGGSHPDCVQLLLRAGS-TVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGC 283
Query: 291 SNLRDINESTPLAYALYCGHTACVKLL 317
+N+ D ++PL A+ A V+LL
Sbjct: 284 ANVVDHQGASPLHLAVRHNFPALVRLL 310
Score = 78.6 bits (192), Expect = 2e-14
Identities = 63/188 (33%), Positives = 88/188 (46%), Gaps = 5/188 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSI-LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
T ++ AA G + L ++ D + LE ++EG T L A G D V+LLL+ G+ +
Sbjct: 194 TALHLAAGRGHMAVLQRLV--DIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTV 251
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
N + L A G + L+ G N+ D G PLH A L+ +L+
Sbjct: 252 NALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLI 311
Query: 148 QQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 207
S++N DN TPLH AA H MLL G D L DK KTAL AV+S +
Sbjct: 312 NSD--SDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNH 369
Query: 208 RILCSIIL 215
L +I+
Sbjct: 370 VSLVDMII 377
Score = 51.6 bits (122), Expect = 2e-06
Identities = 60/248 (24%), Positives = 96/248 (38%), Gaps = 53/248 (21%)
Query: 124 DKNGRLPL----HAATAEPDM-RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
+ +G LPL H A + ++ R+ ++ ++ N NH G LHWAA Q
Sbjct: 8 ETDGLLPLERQLHEAARQNNVGRMQELIGRRVNTRARNHV---GRVALHWAAGAGHEQAV 64
Query: 179 QMLLK-------------------------------------------KGADPTLVDKDF 195
++LL+ GA KD
Sbjct: 65 RLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDG 124
Query: 196 KTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPE 255
T LH A Q G+ + + I+ + + +++ D+ G+T H AA G D + L
Sbjct: 125 LTLLHCAAQKGHVPVLAFIMEDLEDVA-LDHVDKLGRTAFHRAAEHGQLDALDFLVG-SG 182
Query: 256 CNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVK 315
C+ D + T LH AA G +Q L+++G+D ++ T L A H CV+
Sbjct: 183 CDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQ 242
Query: 316 LLSQESRT 323
LL + T
Sbjct: 243 LLLRAGST 250
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 100 bits (248), Expect = 5e-21
Identities = 91/325 (28%), Positives = 137/325 (42%), Gaps = 40/325 (12%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ AA G V + ++ S+ + +G T L A QA+ VK+L+K GANI
Sbjct: 44 LNALHLAAKEGHVGLVQELLGRGSSV-DSATKKGNTALHIASLAGQAEVVKVLVKEGANI 102
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A ++ LL NGA + ++G
Sbjct: 103 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISE------INHQDNEGMTPLHWAAFH 172
RLP LH A + D + +LLQ + ++ +N G TPLH AA +
Sbjct: 163 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 222
Query: 173 NQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGK 232
+LL +GA ++ T LH A + GN + ++L I+ G
Sbjct: 223 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR---GGQIDAKTRDGL 279
Query: 233 TCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSN 292
T +H AA +G ++ EL L A + +PLH AA ECV+ LL+ +
Sbjct: 280 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 338
Query: 293 LRDINESTPLAYALYCGHTACVKLL 317
++ T L A +CGH KLL
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLL 363
Score = 94.4 bits (233), Expect = 3e-19
Identities = 89/295 (30%), Positives = 131/295 (44%), Gaps = 7/295 (2%)
Query: 25 EVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMG 84
E T ++ AA G+VN T ++ ++ + G TPL A + VKLLL G
Sbjct: 210 ESGFTPLHIAAHYGNVNVATLLLNRGAAV-DFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 85 ANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLT 144
I+ + G T L A G + LL GA KNG PLH A + +
Sbjct: 269 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 328
Query: 145 VLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
LLQ + ++ + +T LH AA + T++LL K A+P + T LH A +
Sbjct: 329 HLLQHK--APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 386
Query: 205 SGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
+ +++ + I ESG T +H+AA G +I+ L + + ++
Sbjct: 387 KNRIKVMELLVKYGASIQAIT---ESGLTPIHVAAFMGHLNIVLLLLQ-NGASPDVTNIR 442
Query: 265 DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
T LH AA AG+ E V+ LL G + R E TPL A G T V+LL Q
Sbjct: 443 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497
Score = 89.4 bits (220), Expect = 9e-18
Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 7/289 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A + + +++ SI +S G TP+ A + V LLL+ GA+ +
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITES-GLTPIHVAAFMGHLNIVLLLLQNGASPD 437
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+ + G T+L +A G +E LLRNGA + + + PLH A+ ++ +LLQ
Sbjct: 438 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 497
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
+++ + G TPLH +A Q +LL+ GA +L K T LH A + G+
Sbjct: 498 --HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 555
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ ++L Q + + ++G T +H+AA + + L + A + TP
Sbjct: 556 DVAKLLL---QRRAAADSAGKNGLTPLHVAAHYD-NQKVALLLLEKGASPHATAKNGYTP 611
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + + +LL G ++N+ TPL A GHT V LL
Sbjct: 612 LHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 88.6 bits (218), Expect = 2e-17
Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 7/299 (2%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+ LT ++ AA +G + ++ +L G +PL A G + VK L
Sbjct: 272 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL-ARTKNGLSPLHMAAQGDHVECVKHL 330
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
L+ A ++ T+L +A + G LL A N NG PLH A + +
Sbjct: 331 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 390
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
+++ +L++ + I G+TP+H AAF +LL+ GA P + + +TALH
Sbjct: 391 KVMELLVKYG--ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 448
Query: 201 WAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQA 260
A ++G + +L + ++++ +T +HIA+ G ++I+ L + + A
Sbjct: 449 MAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDA 504
Query: 261 LDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
+ TPLH +A G+ + LLE G +L TPL A G KLL Q
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 563
Score = 84.7 bits (208), Expect = 2e-16
Identities = 90/359 (25%), Positives = 150/359 (41%), Gaps = 29/359 (8%)
Query: 5 ATMDFSTPSVFDQQRG-----------DSSEEVDLTMVYQAASNGDVNALTAVIREDPS- 52
AT D TP Q+G D+ +V L ++ AA D + +++ D +
Sbjct: 138 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 197
Query: 53 ------ILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGW 106
++ G TPL A + LLL GA ++ G T L +A+ G
Sbjct: 198 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 257
Query: 107 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPL 166
LL G + + ++G PLH A +++ +LL++ + + + G++PL
Sbjct: 258 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG--APLLARTKNGLSPL 315
Query: 167 HWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINY 226
H AA + + + LL+ A V D+ TALH A G+ + ++L P N
Sbjct: 316 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NA 372
Query: 227 DDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLE 286
+G T +HIA ++ L + ++QA+ TP+H AA G V LL+
Sbjct: 373 RALNGFTPLHIACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 431
Query: 287 LGMDSNLRDINESTPLAYALYCGHTACVKLLSQ-----ESRTEPTRPPPSQSSRPQKKE 340
G ++ +I T L A G V+ L + ++R + P +SR K E
Sbjct: 432 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 490
Score = 77.4 bits (189), Expect = 4e-14
Identities = 80/296 (27%), Positives = 119/296 (40%), Gaps = 43/296 (14%)
Query: 59 SEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGA 118
S+ + A D V LK G +IN + G +L LA G + LL G+
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 119 KHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
+ K G LH A+ ++ VL+++ + IN Q G TPL+ AA N
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVV 125
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHH-------------------- 218
+ LL+ GA+ + +D T L A+Q G+ +I+L +
Sbjct: 126 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 185
Query: 219 --------------QGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
Q ++N ESG T +HIAA G ++ L A+D
Sbjct: 186 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN----RGAAVDFT 241
Query: 265 DR---TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
R TPLH A+ G V+ LL+ G + + + TPL A GH V+LL
Sbjct: 242 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
Score = 72.8 bits (177), Expect = 9e-13
Identities = 85/347 (24%), Positives = 139/347 (40%), Gaps = 61/347 (17%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G ++ +++ + + G TPL A LLL+ GA+ +
Sbjct: 544 TPLHVAAKYGSLDVAKLLLQRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A ++ +LL GA+ NI K G PLH A+ E ++T+LL
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 662
Query: 149 QSNISEINHQDNEGMTPLHWAAFH--------------NQPQHTQM-------------- 180
+ + I+ G+T LH AA +Q HT++
Sbjct: 663 KG--ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 720
Query: 181 -----LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCV 235
LLK+GA+ K+ T LH A Q G+ + +++L H P N +G T +
Sbjct: 721 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP---NATTANGNTAL 777
Query: 236 HIAAAAGFSDIIHEL-------------------ARVPECNLQALDV-DDRTPLHWAAAA 275
IA G+ ++ L VPE + LDV D+
Sbjct: 778 AIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG 837
Query: 276 GKAECVQSLLELGMDS--NLRDINESTPLAYALYCGHTACVKLLSQE 320
G+ + L ELG DS + + ++ L Y+L G + ++ S +
Sbjct: 838 GEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSD 884
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/148 (29%), Positives = 70/148 (47%), Gaps = 4/148 (2%)
Query: 182 LKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAA 241
LK G D +++ ALH A + G+ L +L S ++ + G T +HIA+ A
Sbjct: 30 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG---SSVDSATKKGNTALHIASLA 86
Query: 242 GFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTP 301
G ++++ L + N+ A + TPL+ AA + V+ LLE G + + + TP
Sbjct: 87 GQAEVVKVLVK-EGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 145
Query: 302 LAYALYCGHTACVKLLSQESRTEPTRPP 329
LA AL GH V +L + R P
Sbjct: 146 LAVALQQGHNQAVAILLENDTKGKVRLP 173
Score = 49.7 bits (117), Expect = 8e-06
Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
+T ++ A+ G + +T ++ + +I G T L A + + +L K GA+
Sbjct: 642 VTPLHLASQEGHTDMVTLLLDKGANI-HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 700
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
+ G T L +A + G ++ LL+ GA N KNG PLH A + ++ VLL
Sbjct: 701 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 760
Query: 148 Q 148
Q
Sbjct: 761 Q 761
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 100 bits (248), Expect = 5e-21
Identities = 91/325 (28%), Positives = 137/325 (42%), Gaps = 40/325 (12%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ AA G V + ++ S+ + +G T L A QA+ VK+L+K GANI
Sbjct: 65 LNALHLAAKEGHVGLVQELLGRGSSV-DSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A ++ LL NGA + ++G
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISE------INHQDNEGMTPLHWAAFH 172
RLP LH A + D + +LLQ + ++ +N G TPLH AA +
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 173 NQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGK 232
+LL +GA ++ T LH A + GN + ++L I+ G
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR---GGQIDAKTRDGL 300
Query: 233 TCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSN 292
T +H AA +G ++ EL L A + +PLH AA ECV+ LL+ +
Sbjct: 301 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 293 LRDINESTPLAYALYCGHTACVKLL 317
++ T L A +CGH KLL
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 94.4 bits (233), Expect = 3e-19
Identities = 89/295 (30%), Positives = 131/295 (44%), Gaps = 7/295 (2%)
Query: 25 EVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMG 84
E T ++ AA G+VN T ++ ++ + G TPL A + VKLLL G
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAV-DFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 85 ANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLT 144
I+ + G T L A G + LL GA KNG PLH A + +
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 145 VLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
LLQ + ++ + +T LH AA + T++LL K A+P + T LH A +
Sbjct: 350 HLLQHK--APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 407
Query: 205 SGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
+ +++ + I ESG T +H+AA G +I+ L + + ++
Sbjct: 408 KNRIKVMELLVKYGASIQAIT---ESGLTPIHVAAFMGHLNIVLLLLQ-NGASPDVTNIR 463
Query: 265 DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
T LH AA AG+ E V+ LL G + R E TPL A G T V+LL Q
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Score = 89.4 bits (220), Expect = 9e-18
Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 7/289 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A + + +++ SI +S G TP+ A + V LLL+ GA+ +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITES-GLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+ + G T+L +A G +E LLRNGA + + + PLH A+ ++ +LLQ
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
+++ + G TPLH +A Q +LL+ GA +L K T LH A + G+
Sbjct: 519 --HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ ++L Q + + ++G T +H+AA + + L + A + TP
Sbjct: 577 DVAKLLL---QRRAAADSAGKNGLTPLHVAAHYD-NQKVALLLLEKGASPHATAKNGYTP 632
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + + +LL G ++N+ TPL A GHT V LL
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 88.6 bits (218), Expect = 2e-17
Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 7/299 (2%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+ LT ++ AA +G + ++ +L G +PL A G + VK L
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL-ARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
L+ A ++ T+L +A + G LL A N NG PLH A + +
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
+++ +L++ + I G+TP+H AAF +LL+ GA P + + +TALH
Sbjct: 412 KVMELLVKYG--ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 201 WAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQA 260
A ++G + +L + ++++ +T +HIA+ G ++I+ L + + A
Sbjct: 470 MAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDA 525
Query: 261 LDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
+ TPLH +A G+ + LLE G +L TPL A G KLL Q
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 84.7 bits (208), Expect = 2e-16
Identities = 90/359 (25%), Positives = 150/359 (41%), Gaps = 29/359 (8%)
Query: 5 ATMDFSTPSVFDQQRG-----------DSSEEVDLTMVYQAASNGDVNALTAVIREDPS- 52
AT D TP Q+G D+ +V L ++ AA D + +++ D +
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 53 ------ILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGW 106
++ G TPL A + LLL GA ++ G T L +A+ G
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 107 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPL 166
LL G + + ++G PLH A +++ +LL++ + + + G++PL
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG--APLLARTKNGLSPL 336
Query: 167 HWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINY 226
H AA + + + LL+ A V D+ TALH A G+ + ++L P N
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NA 393
Query: 227 DDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLE 286
+G T +HIA ++ L + ++QA+ TP+H AA G V LL+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 287 LGMDSNLRDINESTPLAYALYCGHTACVKLLSQ-----ESRTEPTRPPPSQSSRPQKKE 340
G ++ +I T L A G V+ L + ++R + P +SR K E
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511
Score = 77.4 bits (189), Expect = 4e-14
Identities = 80/296 (27%), Positives = 119/296 (40%), Gaps = 43/296 (14%)
Query: 59 SEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGA 118
S+ + A D V LK G +IN + G +L LA G + LL G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 119 KHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
+ K G LH A+ ++ VL+++ + IN Q G TPL+ AA N
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHH-------------------- 218
+ LL+ GA+ + +D T L A+Q G+ +I+L +
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 219 --------------QGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
Q ++N ESG T +HIAA G ++ L A+D
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN----RGAAVDFT 262
Query: 265 DR---TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
R TPLH A+ G V+ LL+ G + + + TPL A GH V+LL
Sbjct: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 72.8 bits (177), Expect = 9e-13
Identities = 85/347 (24%), Positives = 139/347 (40%), Gaps = 61/347 (17%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G ++ +++ + + G TPL A LLL+ GA+ +
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A ++ +LL GA+ NI K G PLH A+ E ++T+LL
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 149 QSNISEINHQDNEGMTPLHWAAFH--------------NQPQHTQM-------------- 180
+ + I+ G+T LH AA +Q HT++
Sbjct: 684 KG--ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
Query: 181 -----LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCV 235
LLK+GA+ K+ T LH A Q G+ + +++L H P N +G T +
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP---NATTANGNTAL 798
Query: 236 HIAAAAGFSDIIHEL-------------------ARVPECNLQALDV-DDRTPLHWAAAA 275
IA G+ ++ L VPE + LDV D+
Sbjct: 799 AIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG 858
Query: 276 GKAECVQSLLELGMDS--NLRDINESTPLAYALYCGHTACVKLLSQE 320
G+ + L ELG DS + + ++ L Y+L G + ++ S +
Sbjct: 859 GEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSD 905
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/148 (29%), Positives = 70/148 (47%), Gaps = 4/148 (2%)
Query: 182 LKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAA 241
LK G D +++ ALH A + G+ L +L S ++ + G T +HIA+ A
Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG---SSVDSATKKGNTALHIASLA 107
Query: 242 GFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTP 301
G ++++ L + N+ A + TPL+ AA + V+ LLE G + + + TP
Sbjct: 108 GQAEVVKVLVK-EGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 302 LAYALYCGHTACVKLLSQESRTEPTRPP 329
LA AL GH V +L + R P
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLP 194
Score = 49.7 bits (117), Expect = 8e-06
Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
+T ++ A+ G + +T ++ + +I G T L A + + +L K GA+
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANI-HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
+ G T L +A + G ++ LL+ GA N KNG PLH A + ++ VLL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 148 Q 148
Q
Sbjct: 782 Q 782
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 100 bits (248), Expect = 5e-21
Identities = 91/325 (28%), Positives = 137/325 (42%), Gaps = 40/325 (12%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ AA G V + ++ S+ + +G T L A QA+ VK+L+K GANI
Sbjct: 65 LNALHLAAKEGHVGLVQELLGRGSSV-DSATKKGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNG-------------------- 127
N Q G T L +A ++ LL NGA + ++G
Sbjct: 124 NAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
Query: 128 --------RLP-LHAATAEPDMRLLTVLLQQSNISE------INHQDNEGMTPLHWAAFH 172
RLP LH A + D + +LLQ + ++ +N G TPLH AA +
Sbjct: 184 ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHY 243
Query: 173 NQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGK 232
+LL +GA ++ T LH A + GN + ++L I+ G
Sbjct: 244 GNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR---GGQIDAKTRDGL 300
Query: 233 TCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSN 292
T +H AA +G ++ EL L A + +PLH AA ECV+ LL+ +
Sbjct: 301 TPLHCAARSGHDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD 359
Query: 293 LRDINESTPLAYALYCGHTACVKLL 317
++ T L A +CGH KLL
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 94.4 bits (233), Expect = 3e-19
Identities = 89/295 (30%), Positives = 131/295 (44%), Gaps = 7/295 (2%)
Query: 25 EVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMG 84
E T ++ AA G+VN T ++ ++ + G TPL A + VKLLL G
Sbjct: 231 ESGFTPLHIAAHYGNVNVATLLLNRGAAV-DFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 85 ANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLT 144
I+ + G T L A G + LL GA KNG PLH A + +
Sbjct: 290 GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVK 349
Query: 145 VLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQ 204
LLQ + ++ + +T LH AA + T++LL K A+P + T LH A +
Sbjct: 350 HLLQHK--APVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACK 407
Query: 205 SGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
+ +++ + I ESG T +H+AA G +I+ L + + ++
Sbjct: 408 KNRIKVMELLVKYGASIQAIT---ESGLTPIHVAAFMGHLNIVLLLLQ-NGASPDVTNIR 463
Query: 265 DRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
T LH AA AG+ E V+ LL G + R E TPL A G T V+LL Q
Sbjct: 464 GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Score = 89.4 bits (220), Expect = 9e-18
Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 7/289 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A + + +++ SI +S G TP+ A + V LLL+ GA+ +
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITES-GLTPIHVAAFMGHLNIVLLLLQNGASPD 458
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+ + G T+L +A G +E LLRNGA + + + PLH A+ ++ +LLQ
Sbjct: 459 VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ 518
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
+++ + G TPLH +A Q +LL+ GA +L K T LH A + G+
Sbjct: 519 --HMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSL 576
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ ++L Q + + ++G T +H+AA + + L + A + TP
Sbjct: 577 DVAKLLL---QRRAAADSAGKNGLTPLHVAAHYD-NQKVALLLLEKGASPHATAKNGYTP 632
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + + +LL G ++N+ TPL A GHT V LL
Sbjct: 633 LHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 88.6 bits (218), Expect = 2e-17
Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 7/299 (2%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D+ LT ++ AA +G + ++ +L G +PL A G + VK L
Sbjct: 293 DAKTRDGLTPLHCAARSGHDQVVELLLERGAPLL-ARTKNGLSPLHMAAQGDHVECVKHL 351
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
L+ A ++ T+L +A + G LL A N NG PLH A + +
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI 411
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
+++ +L++ + I G+TP+H AAF +LL+ GA P + + +TALH
Sbjct: 412 KVMELLVKYG--ASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 469
Query: 201 WAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQA 260
A ++G + +L + ++++ +T +HIA+ G ++I+ L + + A
Sbjct: 470 MAARAGQVEVVRCLL---RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQ-HMAHPDA 525
Query: 261 LDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQ 319
+ TPLH +A G+ + LLE G +L TPL A G KLL Q
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQ 584
Score = 84.7 bits (208), Expect = 2e-16
Identities = 90/359 (25%), Positives = 150/359 (41%), Gaps = 29/359 (8%)
Query: 5 ATMDFSTPSVFDQQRG-----------DSSEEVDLTMVYQAASNGDVNALTAVIREDPS- 52
AT D TP Q+G D+ +V L ++ AA D + +++ D +
Sbjct: 159 ATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNA 218
Query: 53 ------ILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGW 106
++ G TPL A + LLL GA ++ G T L +A+ G
Sbjct: 219 DVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGN 278
Query: 107 LEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPL 166
LL G + + ++G PLH A +++ +LL++ + + + G++PL
Sbjct: 279 TNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG--APLLARTKNGLSPL 336
Query: 167 HWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINY 226
H AA + + + LL+ A V D+ TALH A G+ + ++L P N
Sbjct: 337 HMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP---NA 393
Query: 227 DDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLE 286
+G T +HIA ++ L + ++QA+ TP+H AA G V LL+
Sbjct: 394 RALNGFTPLHIACKKNRIKVMELLVKYG-ASIQAITESGLTPIHVAAFMGHLNIVLLLLQ 452
Query: 287 LGMDSNLRDINESTPLAYALYCGHTACVKLLSQ-----ESRTEPTRPPPSQSSRPQKKE 340
G ++ +I T L A G V+ L + ++R + P +SR K E
Sbjct: 453 NGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTE 511
Score = 77.4 bits (189), Expect = 4e-14
Identities = 80/296 (27%), Positives = 119/296 (40%), Gaps = 43/296 (14%)
Query: 59 SEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGA 118
S+ + A D V LK G +IN + G +L LA G + LL G+
Sbjct: 29 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 88
Query: 119 KHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHT 178
+ K G LH A+ ++ VL+++ + IN Q G TPL+ AA N
Sbjct: 89 SVDSATKKGNTALHIASLAGQAEVVKVLVKEG--ANINAQSQNGFTPLYMAAQENHIDVV 146
Query: 179 QMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHH-------------------- 218
+ LL+ GA+ + +D T L A+Q G+ +I+L +
Sbjct: 147 KYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTK 206
Query: 219 --------------QGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264
Q ++N ESG T +HIAA G ++ L A+D
Sbjct: 207 SAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN----RGAAVDFT 262
Query: 265 DR---TPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
R TPLH A+ G V+ LL+ G + + + TPL A GH V+LL
Sbjct: 263 ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Score = 72.8 bits (177), Expect = 9e-13
Identities = 85/347 (24%), Positives = 139/347 (40%), Gaps = 61/347 (17%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA G ++ +++ + + G TPL A LLL+ GA+ +
Sbjct: 565 TPLHVAAKYGSLDVAKLLLQRRAAA-DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L +A ++ +LL GA+ NI K G PLH A+ E ++T+LL
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD 683
Query: 149 QSNISEINHQDNEGMTPLHWAAFH--------------NQPQHTQM-------------- 180
+ + I+ G+T LH AA +Q HT++
Sbjct: 684 KG--ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNV 741
Query: 181 -----LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCV 235
LLK+GA+ K+ T LH A Q G+ + +++L H P N +G T +
Sbjct: 742 KMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP---NATTANGNTAL 798
Query: 236 HIAAAAGFSDIIHEL-------------------ARVPECNLQALDV-DDRTPLHWAAAA 275
IA G+ ++ L VPE + LDV D+
Sbjct: 799 AIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDG 858
Query: 276 GKAECVQSLLELGMDS--NLRDINESTPLAYALYCGHTACVKLLSQE 320
G+ + L ELG DS + + ++ L Y+L G + ++ S +
Sbjct: 859 GEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSD 905
Score = 58.9 bits (141), Expect = 1e-08
Identities = 44/148 (29%), Positives = 70/148 (47%), Gaps = 4/148 (2%)
Query: 182 LKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAA 241
LK G D +++ ALH A + G+ L +L S ++ + G T +HIA+ A
Sbjct: 51 LKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRG---SSVDSATKKGNTALHIASLA 107
Query: 242 GFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTP 301
G ++++ L + N+ A + TPL+ AA + V+ LLE G + + + TP
Sbjct: 108 GQAEVVKVLVK-EGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTP 166
Query: 302 LAYALYCGHTACVKLLSQESRTEPTRPP 329
LA AL GH V +L + R P
Sbjct: 167 LAVALQQGHNQAVAILLENDTKGKVRLP 194
Score = 49.7 bits (117), Expect = 8e-06
Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
+T ++ A+ G + +T ++ + +I G T L A + + +L K GA+
Sbjct: 663 VTPLHLASQEGHTDMVTLLLDKGANI-HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQ 721
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
+ G T L +A + G ++ LL+ GA N KNG PLH A + ++ VLL
Sbjct: 722 DAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 148 Q 148
Q
Sbjct: 782 Q 782
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 99.4 bits (246), Expect = 9e-21
Identities = 87/312 (27%), Positives = 139/312 (44%), Gaps = 14/312 (4%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A + +T+++ I + G T L A + +LL+ GAN+N
Sbjct: 103 TALHLAVYKDNAELITSLLHSGADIQQV-GYGGLTALHIATIAGHLEAADVLLQHGANVN 161
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+QDA T L +A Y G + LL+ GA N+ + G PLH A+A+ + + +L++
Sbjct: 162 IQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 221
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGAD--PTLVDKDFKTALHWAVQSG 206
+ + +++N QDNE PLH+ + + LL+ + P +V+ T LH A +G
Sbjct: 222 EGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNG 281
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFS-DIIHELARVPECNLQALDVDD 265
+ I+ G + ++ +T H A G S D++ L N+ D
Sbjct: 282 KFEVAKEII-QISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDG 340
Query: 266 RTPLHWAAAAGKAECVQSLLELGMDSNL---------RDINESTPLAYALYCGHTACVKL 316
T LH A G VQ LL+ G D NL + +E T L +A GH A V L
Sbjct: 341 HTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTL 400
Query: 317 LSQESRTEPTRP 328
L R + P
Sbjct: 401 LKHYKRPQDELP 412
Score = 80.1 bits (196), Expect = 6e-15
Identities = 70/258 (27%), Positives = 111/258 (43%), Gaps = 11/258 (4%)
Query: 59 SEGCTPLMH--AVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
+E L+H + G + ++ L+ G + G T+L LA Y E SLL +
Sbjct: 64 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 123
Query: 117 GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQ 176
GA G LH AT + VLLQ + +N QD TPLH AA++ Q
Sbjct: 124 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHG--ANVNIQDAVFFTPLHIAAYYGHEQ 181
Query: 177 HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVH 236
T++LLK GAD + + LH A G + +++ + +N D +H
Sbjct: 182 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM-EEGSKADVNAQDNEDHVPLH 240
Query: 237 IAAAAGFSDIIHELARVP-ECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRD 295
+ G DI+ L + E +++ TPLH A GK E + ++++ +L
Sbjct: 241 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 300
Query: 296 INESTPLAYALYCGHTAC 313
N + A+ H+AC
Sbjct: 301 ENIFSETAF-----HSAC 313
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 99.4 bits (246), Expect = 9e-21
Identities = 87/312 (27%), Positives = 139/312 (44%), Gaps = 14/312 (4%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A + +T+++ I + G T L A + +LL+ GAN+N
Sbjct: 204 TALHLAVYKDNAELITSLLHSGADIQQV-GYGGLTALHIATIAGHLEAADVLLQHGANVN 262
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+QDA T L +A Y G + LL+ GA N+ + G PLH A+A+ + + +L++
Sbjct: 263 IQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLME 322
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGAD--PTLVDKDFKTALHWAVQSG 206
+ + +++N QDNE PLH+ + + LL+ + P +V+ T LH A +G
Sbjct: 323 EGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNG 382
Query: 207 NRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFS-DIIHELARVPECNLQALDVDD 265
+ I+ G + ++ +T H A G S D++ L N+ D
Sbjct: 383 KFEVAKEII-QISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDG 441
Query: 266 RTPLHWAAAAGKAECVQSLLELGMDSNL---------RDINESTPLAYALYCGHTACVKL 316
T LH A G VQ LL+ G D NL + +E T L +A GH A V L
Sbjct: 442 HTGLHSACYHGHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTL 501
Query: 317 LSQESRTEPTRP 328
L R + P
Sbjct: 502 LKHYKRPQDELP 513
Score = 80.1 bits (196), Expect = 6e-15
Identities = 70/258 (27%), Positives = 111/258 (43%), Gaps = 11/258 (4%)
Query: 59 SEGCTPLMH--AVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
+E L+H + G + ++ L+ G + G T+L LA Y E SLL +
Sbjct: 165 TENGLSLLHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHS 224
Query: 117 GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQ 176
GA G LH AT + VLLQ + +N QD TPLH AA++ Q
Sbjct: 225 GADIQQVGYGGLTALHIATIAGHLEAADVLLQHG--ANVNIQDAVFFTPLHIAAYYGHEQ 282
Query: 177 HTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVH 236
T++LLK GAD + + LH A G + +++ + +N D +H
Sbjct: 283 VTRLLLKFGADVNVSGEVGDRPLHLASAKGFLNIAKLLM-EEGSKADVNAQDNEDHVPLH 341
Query: 237 IAAAAGFSDIIHELARVP-ECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRD 295
+ G DI+ L + E +++ TPLH A GK E + ++++ +L
Sbjct: 342 FCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTK 401
Query: 296 INESTPLAYALYCGHTAC 313
N + A+ H+AC
Sbjct: 402 ENIFSETAF-----HSAC 414
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 98.2 bits (243), Expect = 2e-20
Identities = 84/308 (27%), Positives = 137/308 (44%), Gaps = 7/308 (2%)
Query: 14 VFDQQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQ 73
V D + ++ + D T ++ +A G + + ++++ S + G TPL +
Sbjct: 486 VQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP-NAATTSGYTPLHLSAREGH 544
Query: 74 ADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHA 133
D LL GA++++ G T L +A G LE LL+ A + K+G PLH
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 134 ATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDK 193
A + ++ +LL Q + + G TPLH AA NQ LL+ GAD V +
Sbjct: 605 AAHYDNQKVALLLLDQG--ASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTR 662
Query: 194 DFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARV 253
++H A Q G+ + S++L + +N ++SG T +H+AA ++ L
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNAN---VNLSNKSGLTPLHLAAQEDRVNVAEVLVN- 718
Query: 254 PECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTAC 313
++ A TPLH G + V LL+ N + N TPL A GHT
Sbjct: 719 QGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHI 778
Query: 314 VKLLSQES 321
+ +L Q +
Sbjct: 779 INVLLQNN 786
Score = 97.1 bits (240), Expect = 4e-20
Identities = 80/293 (27%), Positives = 131/293 (44%), Gaps = 7/293 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ AA +G + ++ +D + +E + TPL + +AD V+ LL+ GA+ N
Sbjct: 468 TALHMAARSGQAEVVRYLV-QDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
G T L L+ G + LL +GA +I K G PLH A + + +LLQ
Sbjct: 527 AATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQ 586
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
+S + + G+TPLH AA ++ + +LL +GA P K+ T LH A +
Sbjct: 587 KS--ASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQM 644
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ + +L + + + G VH+AA G D++ L N+ + TP
Sbjct: 645 DIATTLLEYGADANAVT---RQGIASVHLAAQEGHVDMV-SLLLGRNANVNLSNKSGLTP 700
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQES 321
LH AA + + L+ G + + TPL + G+ V L Q S
Sbjct: 701 LHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHS 753
Score = 94.4 bits (233), Expect = 3e-19
Identities = 75/294 (25%), Positives = 140/294 (47%), Gaps = 11/294 (3%)
Query: 28 LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANI 87
L ++ A+ G V ++ +++ + ++ + +G T L A QA+ VK+L+ GAN+
Sbjct: 75 LNALHLASKEGHVEVVSELLQREANV-DAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
Query: 88 NMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLL 147
N Q G T L +A LE LL NGA ++ ++G PL A + +++++LL
Sbjct: 134 NAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLL 193
Query: 148 QQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGN 207
+ ++ + LH AA + + +LL+ + + K T LH A GN
Sbjct: 194 ENDTKGKVR------LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN 247
Query: 208 RILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRT 267
+ +++L+ + +++ + T +H+A+ G ++++ +L + A D T
Sbjct: 248 INVATLLLNR---AAAVDFTARNDITPLHVASKRGNANMV-KLLLDRGAKIDAKTRDGLT 303
Query: 268 PLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQES 321
PLH A +G + V+ LL+ + N +PL A H CV+LL Q +
Sbjct: 304 PLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHN 357
Score = 87.8 bits (216), Expect = 3e-17
Identities = 92/360 (25%), Positives = 147/360 (40%), Gaps = 23/360 (6%)
Query: 5 ATMDFSTPSVFDQQRG-----------DSSEEVDLTMVYQAASNGDVNALTAVIREDPSI 53
AT D TP Q+G D+ +V L ++ AA D A +++ D +
Sbjct: 169 ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 54 LECCDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSL 113
+ G TPL A + LLL A ++ T L +A+ G L
Sbjct: 229 -DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL 287
Query: 114 LRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHN 173
L GAK + ++G PLH +++ +LL ++ + I + G++PLH A +
Sbjct: 288 LDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA--APILSKTKNGLSPLHMATQGD 345
Query: 174 QPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKT 233
Q+LL+ V D+ TALH A G+ + ++L P N +G T
Sbjct: 346 HLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP---NAKALNGFT 402
Query: 234 CVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+HIA ++ EL ++QA+ TP+H AA G V L+ G N
Sbjct: 403 PLHIACKKNRIKVM-ELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461
Query: 294 RDINESTPLAYALYCGHTACVKLLSQ-----ESRTEPTRPPPSQSSRPQKKERRFNVLNQ 348
++ T L A G V+ L Q E++ + + P S+R K + +L Q
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521
Score = 85.5 bits (210), Expect = 1e-16
Identities = 69/245 (28%), Positives = 108/245 (44%), Gaps = 6/245 (2%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPL A + ++LLLK GA+I G T + +A ++G + L+ +GA
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQM 180
N + G LH A ++ L+Q E +D++ TPLH +A + Q
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ--TPLHISARLGKADIVQQ 517
Query: 181 LLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAA 240
LL++GA P T LH + + G+ + + +L H SI + G T +H+AA
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT---KKGFTPLHVAAK 574
Query: 241 AGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINEST 300
G ++ + L + + A TPLH AA + LL+ G + N T
Sbjct: 575 YGKLEVANLLLQ-KSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYT 633
Query: 301 PLAYA 305
PL A
Sbjct: 634 PLHIA 638
Score = 82.0 bits (201), Expect = 1e-15
Identities = 64/246 (26%), Positives = 110/246 (44%), Gaps = 6/246 (2%)
Query: 21 DSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLL 80
D++ + LT ++ AA + D + ++ + + G TPL A Q D L
Sbjct: 592 DAAGKSGLTPLHVAA-HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 650
Query: 81 LKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDM 140
L+ GA+ N G S+ LA G ++ LL A N+ +K+G PLH A E +
Sbjct: 651 LEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 710
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
+ VL+ Q + ++ Q G TPLH + + LL+ A K+ T LH
Sbjct: 711 NVAEVLVNQG--AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLH 768
Query: 201 WAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQA 260
A Q G+ + +++L ++ P+ + +G T + IA G+ ++ L V E +
Sbjct: 769 QAAQQGHTHIINVLLQNNASPNELTV---NGNTALGIARRLGYISVVDTLKIVTEETMTT 825
Query: 261 LDVDDR 266
V ++
Sbjct: 826 TTVTEK 831
Score = 80.1 bits (196), Expect = 6e-15
Identities = 81/299 (27%), Positives = 126/299 (42%), Gaps = 14/299 (4%)
Query: 21 DSSEEVDLTMVY-QAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKL 79
D ++ D Y +AA G + I+ I C+ G L A + V
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDI-NICNQNGLNALHLASKEGHVEVVSE 92
Query: 80 LLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPD 139
LL+ AN++ G T+L +A+ G E L+ NGA N +NG PL+ A E
Sbjct: 93 LLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENH 152
Query: 140 MRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTAL 199
+ ++ LL + +D G TPL A Q +LL+ K AL
Sbjct: 153 LEVVKFLLDNGASQSLATED--GFTPLAVALQQGHDQVVSLLLENDTK----GKVRLPAL 206
Query: 200 HWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELA-RVPECNL 258
H A + + +++L + + + +SG T +HIAA G ++ L R +
Sbjct: 207 HIAARKDDTKAAALLLQNDNNADV---ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDF 263
Query: 259 QALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
A +D TPLH A+ G A V+ LL+ G + + + TPL GH V++L
Sbjct: 264 TAR--NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320
Score = 79.7 bits (195), Expect = 7e-15
Identities = 76/289 (26%), Positives = 121/289 (41%), Gaps = 7/289 (2%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T ++ A + + +++ SI +S G TP+ A + V L+ GA+ N
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTES-GLTPIHVAAFMGHVNIVSQLMHHGASPN 460
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+ G T+L +A G E L+++GA+ K+ + PLH + ++ LLQ
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
Q + N G TPLH +A LL GA ++ K T LH A + G
Sbjct: 521 QG--ASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +++L P +SG T +H+AA + + L + A + TP
Sbjct: 579 EVANLLLQKSASPDAAG---KSGLTPLHVAAHYD-NQKVALLLLDQGASPHAAAKNGYTP 634
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
LH AA + + +LLE G D+N + A GH V LL
Sbjct: 635 LHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLL 683
Score = 60.8 bits (146), Expect = 3e-09
Identities = 45/148 (30%), Positives = 72/148 (48%), Gaps = 4/148 (2%)
Query: 182 LKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAA 241
+K G D + +++ ALH A + G+ + S +L Q + ++ + G T +HIA+ A
Sbjct: 61 IKNGVDINICNQNGLNALHLASKEGHVEVVSELL---QREANVDAATKKGNTALHIASLA 117
Query: 242 GFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTP 301
G ++++ L N+ A + TPL+ AA E V+ LL+ G +L + TP
Sbjct: 118 GQAEVVKVLV-TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTP 176
Query: 302 LAYALYCGHTACVKLLSQESRTEPTRPP 329
LA AL GH V LL + R P
Sbjct: 177 LAVALQQGHDQVVSLLLENDTKGKVRLP 204
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 98.2 bits (243), Expect = 2e-20
Identities = 76/223 (34%), Positives = 115/223 (51%), Gaps = 11/223 (4%)
Query: 86 NINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTV 145
N+N QDA G ++L A G LE LL A +I D NG PLH A + + + +
Sbjct: 41 NVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRL 100
Query: 146 LLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQS 205
LL+ S + +N +G PLH AA + + ++MLL+ ++P LV+K KT L A +
Sbjct: 101 LLRAS--AAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEF 158
Query: 206 GNRILCSIILSHHQGPSIINYD-----DESGKTCVHIAAAAGFSDIIHELARVP-ECNLQ 259
G + ++L+ H +++ + D + T +H+AA G ++I +L R E N Q
Sbjct: 159 GRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQ 218
Query: 260 ALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPL 302
T LH AA GK E V+ LLE G+D N+R+ T L
Sbjct: 219 ---TKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTAL 258
Score = 58.5 bits (140), Expect = 2e-08
Identities = 77/349 (22%), Positives = 128/349 (36%), Gaps = 73/349 (20%)
Query: 144 TVLLQQSNISEINHQDNEG---------------------------------MTPLHWAA 170
T LL + +N+QD +G M PLH+AA
Sbjct: 31 TKLLGSTKRLNVNYQDADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAA 90
Query: 171 FHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDES 230
+ + + ++LL+ A D + LH A Q G+ + ++L H P ++N ++
Sbjct: 91 WQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVN---KA 147
Query: 231 GKTCVHIAAAAGFSDIIHELARVPEC-------NLQALDVDDRTPLHWAAAAGKAECVQS 283
KT + +A G + L C D + TPLH AA G E ++
Sbjct: 148 KKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHREVIRQ 207
Query: 284 LLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSSRPQKKERRF 343
LL G++ N R T L A G T V+LL + R +Q++
Sbjct: 208 LLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTA--------L 258
Query: 344 NVLNQIFCKNKKEEQRAHQKDPS--------RDRYREEDTSEVN----DIITTFDSIVGT 391
+++NQ E + ++ S +D + D + +N D+IT +
Sbjct: 259 DIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLE----- 313
Query: 392 NCQEQPGDQVAMVEFKKKTSDNSKYLLPEKKPLARK--GLPPIRTQSLP 438
Q G + ++ +D Y P + K G+P R S P
Sbjct: 314 --QHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAP 360
Score = 31.6 bits (70), Expect = 2.2
Identities = 28/103 (27%), Positives = 42/103 (40%), Gaps = 5/103 (4%)
Query: 57 CDSEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
CD TPL A + ++ LL+ G IN Q G T+L A G E LL
Sbjct: 185 CDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTG-TALHEAALYGKTEVVRLLLEG 243
Query: 117 GAKHNIPDKNGRLPL----HAATAEPDMRLLTVLLQQSNISEI 155
G NI + + L T++ + +L + S I ++
Sbjct: 244 GVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKV 286
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 97.4 bits (241), Expect = 3e-20
Identities = 84/289 (29%), Positives = 136/289 (47%), Gaps = 25/289 (8%)
Query: 71 GRQADTVKLLLKM--GANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR 128
G + + LL M G N+N D+ G T L A G + LLRN A N+ D G
Sbjct: 55 GSSSHPLSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGC 114
Query: 129 LPLHAATAEPDMRLLTVLLQQS-NISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGAD 187
PLH A + D +++ +L+ Q + + +N Q+N+ T LH AA + + ++LL++ D
Sbjct: 115 YPLHLAAWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTD 174
Query: 188 PTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDII 247
PT+ + F+T L A G + ++L+ H P++++ + + T +H+AA G ++
Sbjct: 175 PTMRNNKFETPLDLAALYGRLEVVKMLLNAH--PNLLSCNTKK-HTPLHLAARNGHKAVV 231
Query: 248 HELARV-PECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPL---- 302
L + N Q + + LH AA GK + VQ LL G D N++D + T L
Sbjct: 232 QVLLDAGMDSNYQ---TEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVR 288
Query: 303 ---------AYALYCGHTACVKLLSQESRTEPTRPP--PSQSSRPQKKE 340
AL H + + +T P +PP S S QK +
Sbjct: 289 ELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQ 337
Score = 61.2 bits (147), Expect = 3e-09
Identities = 75/286 (26%), Positives = 112/286 (39%), Gaps = 24/286 (8%)
Query: 13 SVFDQQRGDSSEEVD---LTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAV 69
S+ RG + VD T ++ AA NG + + ++R D ++ DS+GC PL A
Sbjct: 63 SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRND-ALTNVADSKGCYPLHLAA 121
Query: 70 SGRQADTVKLLLKMG---ANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKN 126
A V+LL+ G +N Q+ T+L A G E LL + +
Sbjct: 122 WKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNNK 181
Query: 127 GRLPLHAATAEPDMRLLTVLLQ-QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKG 185
PL A + ++ +LL N+ N + + TPLH AA + Q+LL G
Sbjct: 182 FETPLDLAALYGRLEVVKMLLNAHPNLLSCNTKKH---TPLHLAARNGHKAVVQVLLDAG 238
Query: 186 ADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSD 245
D + +ALH A G + I+L+ + +N D G T + D
Sbjct: 239 MDSN-YQTEMGSALHEAALFGKTDVVQILLA---AGTDVNIKDNHGLTAL---------D 285
Query: 246 IIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDS 291
+ EL + AL D T K Q L MDS
Sbjct: 286 TVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDS 331
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 95.5 bits (236), Expect = 1e-19
Identities = 89/287 (31%), Positives = 126/287 (43%), Gaps = 10/287 (3%)
Query: 61 GCTPLMHAVS-GRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAK 119
G TP A + G A+ L+ + G + QDA G + L LA G LL G
Sbjct: 70 GATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHS 129
Query: 120 HNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQ 179
+ + G PLH A D+ L LL ++ S +N + G +PL+ A Q
Sbjct: 130 ATLETREGARPLHHAAVSGDLTCLK-LLTAAHGSSVNRRTRSGASPLYLACQEGHLHLAQ 188
Query: 180 MLLKK-GADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIA 238
L+K GAD L D +ALH A G+ L +++ + D G T +H A
Sbjct: 189 FLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIG--LTARDNEGATALHFA 246
Query: 239 AAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINE 298
A G + I+ L + L+ D TPLH AA G+ EC Q+L+ +D +LRD +
Sbjct: 247 ARGGHTPILDRLLLMGTPILR--DSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDG 304
Query: 299 STPLAYALYCGHTACVKLLSQESRTEP---TRPPPSQSSRPQKKERR 342
T A Y GH C + L + ++ P T PPP P RR
Sbjct: 305 YTAADLAEYHGHRDCAQYLREVAQPVPLLMTPPPPPFPPPPLLATRR 351
Score = 68.9 bits (167), Expect = 1e-11
Identities = 75/274 (27%), Positives = 110/274 (40%), Gaps = 40/274 (14%)
Query: 17 QQRGDSSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTP------------ 64
Q G+ T + AA+ G + L ++RE L+ D+ G +P
Sbjct: 60 QLPGNQRAHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVL 119
Query: 65 ---LMH-------------------AVSGRQADTVKLLLKMGANINMQDAYGRTSLCLAT 102
L+H AVSG L G+++N + G + L LA
Sbjct: 120 VEWLLHEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLAC 179
Query: 103 YLGWLEGCVSLLRN-GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNE 161
G L L+++ GA ++ +G LHAA A L+ L+ ++I + +DNE
Sbjct: 180 QEGHLHLAQFLVKDCGADVHLRALDGMSALHAAAARGHYSLVVWLVTFTDIG-LTARDNE 238
Query: 162 GMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGP 221
G T LH+AA LL G P L D T LH A ++G C ++SHH P
Sbjct: 239 GATALHFAARGGHTPILDRLLLMGT-PILRDSWGGTPLHDAAENGQMECCQTLVSHHVDP 297
Query: 222 SIINYDDESGKTCVHIAAAAGFSDIIHELARVPE 255
S+ DE G T +A G D L V +
Sbjct: 298 SL---RDEDGYTAADLAEYHGHRDCAQYLREVAQ 328
Score = 54.7 bits (130), Expect = 2e-07
Identities = 47/157 (29%), Positives = 67/157 (42%), Gaps = 3/157 (1%)
Query: 179 QMLLKKGA-DPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHI 237
+ LL+ GA P + D +H A ++G+ ++ Q P N +G T H
Sbjct: 19 ERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPG--NQRAHNGATPAHD 76
Query: 238 AAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDIN 297
AAA G + L R C LQ D +PLH AA G V+ LL G + L
Sbjct: 77 AAATGSLAELCWLVREGGCGLQDQDASGVSPLHLAARFGHPVLVEWLLHEGHSATLETRE 136
Query: 298 ESTPLAYALYCGHTACVKLLSQESRTEPTRPPPSQSS 334
+ PL +A G C+KLL+ + R S +S
Sbjct: 137 GARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGAS 173
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 95.1 bits (235), Expect = 2e-19
Identities = 66/217 (30%), Positives = 111/217 (51%), Gaps = 14/217 (6%)
Query: 84 GANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLL 143
G N+N D+ G T+L A G + + LL+ A N+ D G P+H A + D+ ++
Sbjct: 49 GPNVNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIV 108
Query: 144 TVLLQQS-NISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWA 202
+L+ + S +N Q+NE T LH AA + + +LL++ DPT+ + +T L A
Sbjct: 109 KILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLA 168
Query: 203 VQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALD 262
G + +I+S H P++++ + T +H+AA G ++ L +D
Sbjct: 169 ALYGRLRVVKMIISAH--PNLMSCNTRK-HTPLHLAARNGHKAVVQVLLEA------GMD 219
Query: 263 VDDRT----PLHWAAAAGKAECVQSLLELGMDSNLRD 295
V +T LH AA GK + V+ LLE G+D+N++D
Sbjct: 220 VSCQTEKGSALHEAALFGKVDVVRVLLETGIDANIKD 256
Score = 57.4 bits (137), Expect = 4e-08
Identities = 44/166 (26%), Positives = 71/166 (42%), Gaps = 7/166 (4%)
Query: 155 INHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSII 214
+N D+ G T LH AA + LL+ A + D +H A G+ + I+
Sbjct: 52 VNCTDSSGYTALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKIL 111
Query: 215 LSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARV---PECNLQALDVDDRTPLHW 271
+ H S +N + +T +H AA G S+++ L P L+ TPL
Sbjct: 112 IHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLE----TPLDL 167
Query: 272 AAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLL 317
AA G+ V+ ++ + + + TPL A GH A V++L
Sbjct: 168 AALYGRLRVVKMIISAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
Score = 49.7 bits (117), Expect = 8e-06
Identities = 45/150 (30%), Positives = 66/150 (44%), Gaps = 15/150 (10%)
Query: 175 PQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTC 234
P + + +G + D TALH A +G++ I+L Q + N D G
Sbjct: 39 PLSNLLSIWRGPNVNCTDSSGYTALHHAALNGHK---DIVLKLLQYEASTNVADNKGYFP 95
Query: 235 VHIAAAAGFSDIIHEL-------ARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLEL 287
+H+AA G +I+ L +RV E N + + T LH AA G +E V LLE
Sbjct: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNE-----NETALHCAAQYGHSEVVAVLLEE 150
Query: 288 GMDSNLRDINESTPLAYALYCGHTACVKLL 317
D +R+ TPL A G VK++
Sbjct: 151 LTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
Score = 38.5 bits (88), Expect = 0.018
Identities = 45/173 (26%), Positives = 77/173 (44%), Gaps = 9/173 (5%)
Query: 31 VYQAASNGDVNALTAVIREDPSILECCD--SEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
++ AA GDV + +I PS + +E T L A ++ V +LL+ +
Sbjct: 96 IHLAAWKGDVEIVKILIHHGPSHSRVNEQNNENETALHCAAQYGHSEVVAVLLEELTDPT 155
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGR--LPLHAATAEPDMRLLTVL 146
++++ T L LA G L ++ A N+ N R PLH A ++ VL
Sbjct: 156 IRNSKLETPLDLAALYGRLRVVKMII--SAHPNLMSCNTRKHTPLHLAARNGHKAVVQVL 213
Query: 147 LQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTAL 199
L+ +++ Q +G + LH AA + ++LL+ G D + D +T L
Sbjct: 214 LEAG--MDVSCQTEKG-SALHEAALFGKVDVVRVLLETGIDANIKDSLGRTVL 263
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 95.1 bits (235), Expect = 2e-19
Identities = 93/384 (24%), Positives = 160/384 (41%), Gaps = 7/384 (1%)
Query: 29 TMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
T + A+ G V+ + +++ + LE D G T LM A + D V+LLL GAN +
Sbjct: 73 TALISASKEGHVHIVEELLKCGVN-LEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
+ Y + A G + LL+NGAK N DK G PL A + + + LL
Sbjct: 132 VTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLA 191
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
++++ + MT L A Q + +LK+ + L DKD TAL A + G+
Sbjct: 192 MG--ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHT 249
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTP 268
+ +L + +N D SG T + A G +I+ L + ++ D++T
Sbjct: 250 EIVQDLL---DAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQ-KYADIDIRGQDNKTA 305
Query: 269 LHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESRTEPTRP 328
L+WA G A V+ +L+ D+ + + TPL A + V+LL +
Sbjct: 306 LYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365
Query: 329 PPSQSSRPQKKERRFNVLNQIFCKNKKEEQRAHQKDPSRDRYREEDTSEVNDIITTFDSI 388
+ R L ++ +N K+ + ++ + + + D S I+T
Sbjct: 366 KKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSHQKSILTQIFGA 425
Query: 389 VGTNCQEQPGDQVAMVEFKKKTSD 412
+ E GD + + +D
Sbjct: 426 RHLSPTETDGDMLGYDLYSSALAD 449
Score = 82.4 bits (202), Expect = 1e-15
Identities = 78/267 (29%), Positives = 116/267 (43%), Gaps = 20/267 (7%)
Query: 61 GCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH 120
G TPLM A + VK L+K GAN N++D T+L A+ G + LL+ G
Sbjct: 38 GQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNL 97
Query: 121 NIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDNEGMT------PLHWAAFHNQ 174
D G L A + ++ +LL +H N +T P+ WAA
Sbjct: 98 EHRDMGGWTALMWACYKGRTDVVELLL--------SHGANPSVTGLYSVYPIIWAAGRGH 149
Query: 175 PQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTC 234
+LL+ GA DK T L WA + G+ +L+ + ++ + + T
Sbjct: 150 ADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAM---GADVDQEGANSMTA 206
Query: 235 VHIAAAAGFSDIIHE-LARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNL 293
+ +A G++ + E L R P NL D D T L A+ G E VQ LL+ G N+
Sbjct: 207 LIVAVKGGYTQSVKEILKRNPNVNL--TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNI 264
Query: 294 RDINESTPLAYALYCGHTACVKLLSQE 320
D + T L A+ GH V+ L Q+
Sbjct: 265 PDRSGDTVLIGAVRGGHVEIVRALLQK 291
Score = 75.1 bits (183), Expect = 2e-13
Identities = 66/236 (27%), Positives = 105/236 (44%), Gaps = 12/236 (5%)
Query: 23 SEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGC---TPLMHAVSGRQADTVKL 79
S++ T + AA G + + ++ + D EG T L+ AV G +VK
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADV----DQEGANSMTALIVAVKGGYTQSVKE 221
Query: 80 LLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPD 139
+LK N+N+ D G T+L +A+ G E LL G NIPD++G L A
Sbjct: 222 ILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGH 281
Query: 140 MRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTAL 199
+ ++ LLQ+ +I QDN+ T L+WA + +L+ D + KD +T L
Sbjct: 282 VEIVRALLQKYADIDIRGQDNK--TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPL 339
Query: 200 HWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPE 255
A + N + ++L S + D+ G T +HIA + L R P+
Sbjct: 340 IKATKMRNIEVVELLLDKGAKVSAV---DKKGDTPLHIAIRGRSRKLAELLLRNPK 392
Score = 48.9 bits (115), Expect = 1e-05
Identities = 34/91 (37%), Positives = 51/91 (56%), Gaps = 3/91 (3%)
Query: 228 DESGKTCVHIAAAAGFSDIIHELARV-PECNLQALDVDDRTPLHWAAAAGKAECVQSLLE 286
+E G+T + IAA G +I+ EL + CNL+ D+D+ T L A+ G V+ LL+
Sbjct: 35 NECGQTPLMIAAEQGNLEIVKELIKNGANCNLE--DLDNWTALISASKEGHVHIVEELLK 92
Query: 287 LGMDSNLRDINESTPLAYALYCGHTACVKLL 317
G++ RD+ T L +A Y G T V+LL
Sbjct: 93 CGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 94.7 bits (234), Expect = 2e-19
Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 7/219 (3%)
Query: 31 VYQAASNGDVNALTAVIRE--DPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
+Y + G++ + ++ + DP+ S+ TPL A + +LL+ GANIN
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKR-TPLHAAAQKGSVEICHVLLQAGANIN 678
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
D RT L A LE +++ G +++G LH A ++ ++++LL
Sbjct: 679 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 738
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
+ ++N QD+ G TP+ WAA H + +MLL +GAD TL D + LHWA +G+
Sbjct: 739 TGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 797
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDII 247
+ ++L+ +NY G T +HIAA + D +
Sbjct: 798 AIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCV 833
Score = 70.5 bits (171), Expect = 4e-12
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 7/221 (3%)
Query: 98 LCLATYLGWLEGCVSLLRNGAKHNIPD--KNGRLPLHAATAEPDMRLLTVLLQQSNISEI 155
L L+ G L+ + +L + N ++ R PLHAA + + + VLLQ + I
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAG--ANI 677
Query: 156 NHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIIL 215
N D + TPL A +N + + ++++G ++D T LH A + GN + S++L
Sbjct: 678 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 737
Query: 216 SHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAA 275
S G +N D G T + AA ++I L ++ D ++ LHWA+
Sbjct: 738 S--TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEENICLHWASFT 794
Query: 276 GKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKL 316
G A + LL D + + + TPL A + CV L
Sbjct: 795 GSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Score = 68.2 bits (165), Expect = 2e-11
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 3/187 (1%)
Query: 131 LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTL 190
L+ + + +++ + ++L + TPLH AA + +LL+ GA+
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 191 VDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL 250
VDK +T L AV + + + ++ Q + +E G TC+H AA G +++ L
Sbjct: 680 VDKQQRTPLMEAVVNNHLEVARYMV---QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736
Query: 251 ARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGH 310
+ ++ A D TP+ WAA E ++ LL G D L D E+ L +A + G
Sbjct: 737 LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGS 796
Query: 311 TACVKLL 317
A ++L
Sbjct: 797 AAIAEVL 803
Score = 63.2 bits (152), Expect = 7e-10
Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 4/210 (1%)
Query: 22 SSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLL 81
S ++ T ++ AA G V +++ +I D + TPLM AV + + ++
Sbjct: 646 SDQQSKRTPLHAAAQKGSVEICHVLLQAGANI-NAVDKQQRTPLMEAVVNNHLEVARYMV 704
Query: 82 KMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH-NIPDKNGRLPLHAATAEPDM 140
+ G + ++ G T L A +G LE LL G N D G P+ A +
Sbjct: 705 QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI 764
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
++ +LL + +++ DNE LHWA+F ++LL D V+ T LH
Sbjct: 765 EVIRMLLTRG--ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLH 822
Query: 201 WAVQSGNRILCSIILSHHQGPSIINYDDES 230
A + + LS P + N + ++
Sbjct: 823 IAARESYHDCVLLFLSRGANPELRNKEGDT 852
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 5/143 (3%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMG-ANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
+ +G T L HA + V LLL G ++N QD+ G T + A +E LL
Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 117 GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ-QSNISEINHQDNEGMTPLHWAAFHNQP 175
GA + D + LH A+ + VLL + ++ +N+ G TPLH AA +
Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYH---GDTPLHIAARESYH 830
Query: 176 QHTQMLLKKGADPTLVDKDFKTA 198
+ L +GA+P L +K+ TA
Sbjct: 831 DCVLLFLSRGANPELRNKEGDTA 853
Score = 38.5 bits (88), Expect = 0.018
Identities = 22/63 (34%), Positives = 29/63 (46%)
Query: 257 NLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKL 316
N Q+ RTPLH AA G E LL+ G + N D + TPL A+ H +
Sbjct: 643 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARY 702
Query: 317 LSQ 319
+ Q
Sbjct: 703 MVQ 705
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 94.7 bits (234), Expect = 2e-19
Identities = 64/219 (29%), Positives = 108/219 (49%), Gaps = 7/219 (3%)
Query: 31 VYQAASNGDVNALTAVIRE--DPSILECCDSEGCTPLMHAVSGRQADTVKLLLKMGANIN 88
+Y + G++ + ++ + DP+ S+ TPL A + +LL+ GANIN
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKR-TPLHAAAQKGSVEICHVLLQAGANIN 712
Query: 89 MQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ 148
D RT L A LE +++ G +++G LH A ++ ++++LL
Sbjct: 713 AVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLS 772
Query: 149 QSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNR 208
+ ++N QD+ G TP+ WAA H + +MLL +GAD TL D + LHWA +G+
Sbjct: 773 TGQV-DVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSA 831
Query: 209 ILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDII 247
+ ++L+ +NY G T +HIAA + D +
Sbjct: 832 AIAEVLLNARCDLHAVNY---HGDTPLHIAARESYHDCV 867
Score = 70.5 bits (171), Expect = 4e-12
Identities = 61/221 (27%), Positives = 100/221 (45%), Gaps = 7/221 (3%)
Query: 98 LCLATYLGWLEGCVSLLRNGAKHNIPD--KNGRLPLHAATAEPDMRLLTVLLQQSNISEI 155
L L+ G L+ + +L + N ++ R PLHAA + + + VLLQ + I
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAG--ANI 711
Query: 156 NHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIIL 215
N D + TPL A +N + + ++++G ++D T LH A + GN + S++L
Sbjct: 712 NAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLL 771
Query: 216 SHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVDDRTPLHWAAAA 275
S G +N D G T + AA ++I L ++ D ++ LHWA+
Sbjct: 772 S--TGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLL-TRGADVTLTDNEENICLHWASFT 828
Query: 276 GKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKL 316
G A + LL D + + + TPL A + CV L
Sbjct: 829 GSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Score = 68.2 bits (165), Expect = 2e-11
Identities = 49/187 (26%), Positives = 86/187 (45%), Gaps = 3/187 (1%)
Query: 131 LHAATAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTL 190
L+ + + +++ + ++L + TPLH AA + +LL+ GA+
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 191 VDKDFKTALHWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHEL 250
VDK +T L AV + + + ++ Q + +E G TC+H AA G +++ L
Sbjct: 714 VDKQQRTPLMEAVVNNHLEVARYMV---QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770
Query: 251 ARVPECNLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGH 310
+ ++ A D TP+ WAA E ++ LL G D L D E+ L +A + G
Sbjct: 771 LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGS 830
Query: 311 TACVKLL 317
A ++L
Sbjct: 831 AAIAEVL 837
Score = 63.2 bits (152), Expect = 7e-10
Identities = 52/210 (24%), Positives = 89/210 (42%), Gaps = 4/210 (1%)
Query: 22 SSEEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLL 81
S ++ T ++ AA G V +++ +I D + TPLM AV + + ++
Sbjct: 680 SDQQSKRTPLHAAAQKGSVEICHVLLQAGANI-NAVDKQQRTPLMEAVVNNHLEVARYMV 738
Query: 82 KMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKH-NIPDKNGRLPLHAATAEPDM 140
+ G + ++ G T L A +G LE LL G N D G P+ A +
Sbjct: 739 QRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHI 798
Query: 141 RLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALH 200
++ +LL + +++ DNE LHWA+F ++LL D V+ T LH
Sbjct: 799 EVIRMLLTRG--ADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLH 856
Query: 201 WAVQSGNRILCSIILSHHQGPSIINYDDES 230
A + + LS P + N + ++
Sbjct: 857 IAARESYHDCVLLFLSRGANPELRNKEGDT 886
Score = 54.3 bits (129), Expect = 3e-07
Identities = 44/143 (30%), Positives = 67/143 (46%), Gaps = 5/143 (3%)
Query: 58 DSEGCTPLMHAVSGRQADTVKLLLKMG-ANINMQDAYGRTSLCLATYLGWLEGCVSLLRN 116
+ +G T L HA + V LLL G ++N QD+ G T + A +E LL
Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 117 GAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQ-QSNISEINHQDNEGMTPLHWAAFHNQP 175
GA + D + LH A+ + VLL + ++ +N+ G TPLH AA +
Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYH---GDTPLHIAARESYH 864
Query: 176 QHTQMLLKKGADPTLVDKDFKTA 198
+ L +GA+P L +K+ TA
Sbjct: 865 DCVLLFLSRGANPELRNKEGDTA 887
Score = 38.5 bits (88), Expect = 0.018
Identities = 22/63 (34%), Positives = 29/63 (46%)
Query: 257 NLQALDVDDRTPLHWAAAAGKAECVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKL 316
N Q+ RTPLH AA G E LL+ G + N D + TPL A+ H +
Sbjct: 677 NFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARY 736
Query: 317 LSQ 319
+ Q
Sbjct: 737 MVQ 739
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.129 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,522,910
Number of Sequences: 37866
Number of extensions: 1209863
Number of successful extensions: 8945
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 351
Number of HSP's successfully gapped in prelim test: 57
Number of HSP's that attempted gapping in prelim test: 4140
Number of HSP's gapped (non-prelim): 2036
length of query: 614
length of database: 18,247,518
effective HSP length: 108
effective length of query: 506
effective length of database: 14,157,990
effective search space: 7163942940
effective search space used: 7163942940
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.