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Search of human proteins with 14149746
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149746 nuclear receptor subfamily 2, group F, member 2
isoform a [Homo sapiens]
(414 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 854 0.0
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 730 0.0
gi|223555949 nuclear receptor subfamily 2, group F, member 2 iso... 536 e-152
gi|223555953 nuclear receptor subfamily 2, group F, member 2 iso... 524 e-149
gi|223555951 nuclear receptor subfamily 2, group F, member 2 iso... 524 e-149
gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Hom... 499 e-141
gi|11415052 retinoid X receptor, beta [Homo sapiens] 284 9e-77
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 283 2e-76
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 278 6e-75
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 276 3e-74
gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo... 254 1e-67
gi|7706515 photoreceptor-specific nuclear receptor isoform a [Ho... 233 3e-61
gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo sa... 223 2e-58
gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo sa... 223 2e-58
gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo sa... 223 2e-58
gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo sa... 223 2e-58
gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo sa... 220 2e-57
gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo sa... 220 2e-57
gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens] 218 6e-57
gi|238550159 estrogen-related receptor beta [Homo sapiens] 195 6e-50
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 191 8e-49
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 191 8e-49
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 191 8e-49
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 191 8e-49
gi|18860920 estrogen-related receptor alpha [Homo sapiens] 185 6e-47
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 177 2e-44
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 177 2e-44
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 172 4e-43
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 166 3e-41
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 163 3e-40
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 854 bits (2207), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQ 60
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQ
Sbjct: 1 MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQ 60
Query: 61 GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN 120
GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN
Sbjct: 61 GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN 120
Query: 121 CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSG 180
CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSG
Sbjct: 121 CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSG 180
Query: 181 YISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITD 240
YISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITD
Sbjct: 181 YISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITD 240
Query: 241 QVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVE 300
QVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVE
Sbjct: 241 QVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVE 300
Query: 301 KLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRF 360
KLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRF
Sbjct: 301 KLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRF 360
Query: 361 GKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 414
GKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
Sbjct: 361 GKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 414
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 730 bits (1885), Expect = 0.0
Identities = 366/426 (85%), Positives = 379/426 (88%), Gaps = 17/426 (3%)
Query: 1 MAMVVSTWRDPQDEVPGSQG---SQASQAPPVPG---------PPPGAPHTPQTPGQGGP 48
MAMVVS+WRDPQD+V G + A+QA G GAPHTPQTPGQ G
Sbjct: 1 MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA 60
Query: 49 ASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVR 108
+TP GQG PG Q QQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVR
Sbjct: 61 PATPGTAGDKGQGPPGSG-----QSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVR 115
Query: 109 RNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTN 168
RNL+YTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQP GQ+ALTN
Sbjct: 116 RNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTN 175
Query: 169 GDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWAR 228
GDPLN H YLSGYISLLLRAEPYPTSR+GSQCMQPNNIMGIENICELAAR+LFSAVEWAR
Sbjct: 176 GDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWAR 235
Query: 229 NIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAF 288
NIPFFPDLQITDQV+LLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAF
Sbjct: 236 NIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAF 295
Query: 289 MDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEY 348
MDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSD AH+ESLQEKSQCALEEY
Sbjct: 296 MDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEY 355
Query: 349 VRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNW 408
VRSQYPNQP+RFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNW
Sbjct: 356 VRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNW 415
Query: 409 PYMAIQ 414
PYM+IQ
Sbjct: 416 PYMSIQ 421
>gi|223555949 nuclear receptor subfamily 2, group F, member 2
isoform b [Homo sapiens]
Length = 281
Score = 536 bits (1380), Expect = e-152
Identities = 269/275 (97%), Positives = 270/275 (98%)
Query: 140 LKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQ 199
L+ G AVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQ
Sbjct: 7 LEQGKYGFAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQ 66
Query: 200 CMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQ 259
CMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQ
Sbjct: 67 CMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQ 126
Query: 260 CSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIV 319
CSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIV
Sbjct: 127 CSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIV 186
Query: 320 LFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIE 379
LFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIE
Sbjct: 187 LFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIE 246
Query: 380 QLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 414
QLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
Sbjct: 247 QLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ 281
>gi|223555953 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 524 bits (1350), Expect = e-149
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 154 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC 213
MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC
Sbjct: 1 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC 60
Query: 214 ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA 273
ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA
Sbjct: 61 ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA 120
Query: 274 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH 333
GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH
Sbjct: 121 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH 180
Query: 334 VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 393
VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE
Sbjct: 181 VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 240
Query: 394 TLIRDMLLSGSSFNWPYMAIQ 414
TLIRDMLLSGSSFNWPYMAIQ
Sbjct: 241 TLIRDMLLSGSSFNWPYMAIQ 261
>gi|223555951 nuclear receptor subfamily 2, group F, member 2
isoform c [Homo sapiens]
Length = 261
Score = 524 bits (1350), Expect = e-149
Identities = 261/261 (100%), Positives = 261/261 (100%)
Query: 154 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC 213
MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC
Sbjct: 1 MPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENIC 60
Query: 214 ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA 273
ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA
Sbjct: 61 ELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAA 120
Query: 274 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH 333
GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH
Sbjct: 121 GLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAH 180
Query: 334 VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 393
VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE
Sbjct: 181 VESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIE 240
Query: 394 TLIRDMLLSGSSFNWPYMAIQ 414
TLIRDMLLSGSSFNWPYMAIQ
Sbjct: 241 TLIRDMLLSGSSFNWPYMAIQ 261
>gi|20070199 nuclear receptor subfamily 2, group F, member 6 [Homo
sapiens]
Length = 404
Score = 499 bits (1285), Expect = e-141
Identities = 258/398 (64%), Positives = 300/398 (75%), Gaps = 31/398 (7%)
Query: 42 TPGQGGPAS-TPAQTAAGG--------QGGPGGPGSDKQQQQQH-----IECVVCGDKSS 87
T G GGP T AGG P G SD + + ++CVVCGDKSS
Sbjct: 5 TGGWGGPGGDTNGVDKAGGYPRAAEDDSASPPGAASDAEPGDEERPGLQVDCVVCGDKSS 64
Query: 88 GKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRRE 147
GKHYG FTCEGCKSFFKRS+RRNLSYTCR+NR+C IDQHHRNQCQYCRLKKC +VGMR+E
Sbjct: 65 GKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRVGMRKE 124
Query: 148 AVQRGRMPPTQPTHGQFALTNGDP-------------LNCHSYLSGYISLLLRAEPYPTS 194
AVQRGR+P + P G A ++G P L +S I+ LLRAEPYP +
Sbjct: 125 AVQRGRIPHSLP--GAVAASSGSPPGSALAAVASGGDLFPGQPVSELIAQLLRAEPYPAA 182
Query: 195 --RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSEL 252
RFG+ ++GI+N+CELAAR+LFS VEWAR+ PFFP+L + DQVALLRL+WSEL
Sbjct: 183 AGRFGAGGGAAGAVLGIDNVCELAARLLFSTVEWARHAPFFPELPVADQVALLRLSWSEL 242
Query: 253 FVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEY 312
FVLNAAQ ++PLH APLLAAAGLHA+PM+A+R VAFMD +R FQEQV+KL L VDSAEY
Sbjct: 243 FVLNAAQAALPLHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDSAEY 302
Query: 313 SCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRT 372
CLKAI LFT DACGLSD AHVESLQEK+Q AL EYVR+QYP+QP RFG+LLLRLP+LR
Sbjct: 303 GCLKAIALFTPDACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRA 362
Query: 373 VSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
V +S+I QLFF+RLVGKTPIETLIRDMLLSGS+FNWPY
Sbjct: 363 VPASLISQLFFMRLVGKTPIETLIRDMLLSGSTFNWPY 400
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 284 bits (727), Expect = 9e-77
Identities = 164/433 (37%), Positives = 231/433 (53%), Gaps = 55/433 (12%)
Query: 11 PQDEVPGSQGSQASQAPPVPGPPPGAPHT-------------PQTPGQGGPASTP----- 52
P P GS A PP+P PP G+P P PG GP S+P
Sbjct: 106 PPSTAPSLGGSGAPPPPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINST 165
Query: 53 AQTAAGGQGGP-------------------GGPGSDKQQQQQHIECVVCGDKSSGKHYGQ 93
GG G P GGPG+ K+ C +CGD+SSGKHYG
Sbjct: 166 VSLPGGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRL------CAICGDRSSGKHYGV 219
Query: 94 FTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGR 153
++CEGCK FFKR++R++L+Y+CR N++C +D+ RN+CQYCR +KCL GM+REAVQ R
Sbjct: 220 YSCEGCKGFFKRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEER 279
Query: 154 M-PPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAE-----PYPTSRFGSQCMQPNNIM 207
+ G+ A + + L +++ +++ P T GS P
Sbjct: 280 QRGKDKDGDGEGAGGAPEEMPVDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDP---- 335
Query: 208 GIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVA 267
+ NIC+ A + LF+ VEWA+ IP F L + DQV LLR W+EL + + + S+ +
Sbjct: 336 -VTNICQAADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDG 394
Query: 268 PLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACG 327
+L A GLH SA R+ E V K++ + +D E CL+AI+LF DA G
Sbjct: 395 -ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKG 453
Query: 328 LSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLV 387
LS+ + VE L+EK +LE Y + +YP Q RF KLLLRLP+LR++ +E LFF +L+
Sbjct: 454 LSNPSEVEVLREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLI 513
Query: 388 GKTPIETLIRDML 400
G TPI+T + +ML
Sbjct: 514 GDTPIDTFLMEML 526
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 283 bits (725), Expect = 2e-76
Identities = 155/396 (39%), Positives = 222/396 (56%), Gaps = 10/396 (2%)
Query: 11 PQDEVPGSQGSQASQAPPVP--GPPPGAPH--TPQTPGQGGPASTPAQTAAGGQGGPGGP 66
P + G + P P G G+P +P P P G P P
Sbjct: 64 PFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHP 123
Query: 67 GSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQH 126
+ +HI C +CGD+SSGKHYG ++CEGCK FFKR+VR++L+YTCR N++C ID+
Sbjct: 124 SGNMASFTKHI-CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR 182
Query: 127 HRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTN--GDPLNCHSYLSGYISL 184
RN+CQYCR +KCL +GM+REAVQ R + T+ + + L +++
Sbjct: 183 QRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAV 242
Query: 185 LLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVAL 244
+ E Y + G PN+ + NIC+ A + LF+ VEWA+ IP F +L + DQV L
Sbjct: 243 EPKTETYVEANMGLNPSSPND--PVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL 300
Query: 245 LRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKA 304
LR W+EL + + + S+ + +L A GLH SA R+ E V K++
Sbjct: 301 LRAGWNELLIASFSHRSIAVKDG-ILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRD 359
Query: 305 LHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLL 364
+ +D E CL+AIVLF D+ GLS+ A VE+L+EK +LE Y + +YP QP RF KLL
Sbjct: 360 MQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLL 419
Query: 365 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 400
LRLP+LR++ +E LFF +L+G TPI+T + +ML
Sbjct: 420 LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEML 455
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 278 bits (711), Expect = 6e-75
Identities = 155/386 (40%), Positives = 217/386 (56%), Gaps = 23/386 (5%)
Query: 31 GPPPGAPHTPQTPGQGGPASTPAQTAAG--------------GQGGPGGPGSDKQQQQQH 76
GPP GA P P S+ G G P + +H
Sbjct: 78 GPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKH 137
Query: 77 IECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRL 136
I C +CGD+SSGKHYG ++CEGCK FFKR++R++L YTCR N++C ID+ RN+CQYCR
Sbjct: 138 I-CAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRY 196
Query: 137 KKCLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTS 194
+KCL +GM+REAVQ R R + + A + + + L +++ EP T
Sbjct: 197 QKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAV----EP-KTE 251
Query: 195 RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFV 254
+G M+ + + NIC A + LF+ VEWA+ IP F DL + DQV LLR W+EL +
Sbjct: 252 SYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLI 311
Query: 255 LNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSC 314
+ + S+ + +L A GLH SA R+ E V K+K + +D +E C
Sbjct: 312 ASFSHRSVSVQDG-ILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGC 370
Query: 315 LKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVS 374
L+AIVLF DA GLS+ + VE+L+EK LE Y + +YP QP RF KLLLRLP+LR++
Sbjct: 371 LRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIG 430
Query: 375 SSVIEQLFFVRLVGKTPIETLIRDML 400
+E LFF +L+G TPI+T + +ML
Sbjct: 431 LKCLEHLFFFKLIGDTPIDTFLMEML 456
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 276 bits (705), Expect = 3e-74
Identities = 158/393 (40%), Positives = 218/393 (55%), Gaps = 42/393 (10%)
Query: 49 ASTPAQTAAGGQGGPG--GPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRS 106
A+ PA AA + PG G G D ++C VCGD SSGKHYG + C GC FFKRS
Sbjct: 15 AAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRS 74
Query: 107 VRRNLSYTCRANRN-CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMP-PTQPTHGQF 164
VRR L Y C+ CP+D+ HRNQCQ CRLKKCL+ GM ++AVQ R P T H
Sbjct: 75 VRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDS 134
Query: 165 ALTNGD---------------------PLNC-----HSYLSGYISLLLRAEPYPTS---- 194
+N + P++ H +++ I+ A+ P
Sbjct: 135 MESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADEN 194
Query: 195 --------RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLR 246
F S ++ G+++I E +AR+LF AV+WA+N+P F L DQV LL
Sbjct: 195 IDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLE 254
Query: 247 LTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALH 306
WSELF+L A Q S+PL PLLA A+ + R+ R+ QE + + +AL
Sbjct: 255 EAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALA 314
Query: 307 VDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLR 366
VD E++C+KA+VLF + GL D HVE+LQ++SQ L ++ ++ +P+QP RFGKLLL
Sbjct: 315 VDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLL 374
Query: 367 LPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDM 399
LPSLR +++ IE LFF + +G TP+E L+ DM
Sbjct: 375 LPSLRFITAERIELLFFRKTIGNTPMEKLLCDM 407
>gi|4507537 nuclear receptor subfamily 2, group E, member 1 [Homo
sapiens]
Length = 385
Score = 254 bits (649), Expect = 1e-67
Identities = 139/375 (37%), Positives = 208/375 (55%), Gaps = 55/375 (14%)
Query: 77 IECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN--CPIDQHHRNQCQYC 134
I C VCGD+SSGKHYG + C+GC FFKRS+RRN +Y C++ CP+D+ HRNQC+ C
Sbjct: 14 IPCKVCGDRSSGKHYGVYACDGCSGFFKRSIRRNRTYVCKSGNQGGCPVDKTHRNQCRAC 73
Query: 135 RLKKCLKVGMRREAVQRGRMPPTQPTHGQFAL-------TNGDPLNCHSYL---SGYISL 184
RLKKCL+V M ++AVQ R P T Q AL NG + S + +
Sbjct: 74 RLKKCLEVNMNKDAVQHERGPRTSTIRKQVALYFRGHKEENGAAAHFPSAALPAPAFFTA 133
Query: 185 LLRAEPY---------------------PTSRFGSQCMQPNNIMGI---------ENICE 214
+ + EP+ PT ++ P+ + G E++CE
Sbjct: 134 VTQLEPHGLELAAVSTTPERQTLVSLAQPTPKY------PHEVNGTPMYLYEVATESVCE 187
Query: 215 LAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAG 274
AAR+LF +++WA+++P F L + DQ+ LL W ELFVL AQ ++P+ LLA +G
Sbjct: 188 SAARLLFMSIKWAKSVPAFSTLSLQDQLMLLEDAWRELFVLGIAQWAIPVDANTLLAVSG 247
Query: 275 LHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFT-------SDACG 327
++ + ++ + I+ QE V + + L +D+ E++CLK IV F S+
Sbjct: 248 MNGDNTDSQKLNKIISEIQALQEVVARFRQLRLDATEFACLKCIVTFKAVPTHSGSELRS 307
Query: 328 LSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLV 387
+ A + +LQ+++Q L Y+ ++YP QP RFGKLLL LP+LR++S S IE++FF + +
Sbjct: 308 FRNAAAIAALQDEAQLTLNSYIHTRYPTQPCRFGKLLLLLPALRSISPSTIEEVFFKKTI 367
Query: 388 GKTPIETLIRDMLLS 402
G PI L+ DM S
Sbjct: 368 GNVPITRLLSDMYKS 382
>gi|7706515 photoreceptor-specific nuclear receptor isoform a [Homo
sapiens]
Length = 367
Score = 233 bits (593), Expect = 3e-61
Identities = 135/353 (38%), Positives = 188/353 (53%), Gaps = 42/353 (11%)
Query: 49 ASTPAQTAAGGQGGPG--GPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRS 106
A+ PA AA + PG G G D ++C VCGD SSGKHYG + C GC FFKRS
Sbjct: 15 AAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRS 74
Query: 107 VRRNLSYTCRANRN-CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMP-PTQPTHGQF 164
VRR L Y C+ CP+D+ HRNQCQ CRLKKCL+ GM ++AVQ R P T H
Sbjct: 75 VRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDS 134
Query: 165 ALTNGD---------------------PLNC-----HSYLSGYISLLLRAEPYPTS---- 194
+N + P++ H +++ I+ A+ P
Sbjct: 135 MESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADEN 194
Query: 195 --------RFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLR 246
F S ++ G+++I E +AR+LF AV+WA+N+P F L DQV LL
Sbjct: 195 IDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLE 254
Query: 247 LTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALH 306
WSELF+L A Q S+PL PLLA A+ + R+ R+ QE + + +AL
Sbjct: 255 EAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALA 314
Query: 307 VDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTR 359
VD E++C+KA+VLF + GL D HVE+LQ++SQ L ++ ++ +P+QP R
Sbjct: 315 VDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVR 367
>gi|31077207 hepatocyte nuclear factor 4 alpha isoform a [Homo
sapiens]
Length = 464
Score = 223 bits (569), Expect = 2e-58
Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 172
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
Query: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
Query: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
Query: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|31077205 hepatocyte nuclear factor 4 alpha isoform b [Homo
sapiens]
Length = 474
Score = 223 bits (569), Expect = 2e-58
Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 172
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
Query: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
Query: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
Query: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 384
>gi|71725341 hepatocyte nuclear factor 4 alpha isoform e [Homo
sapiens]
Length = 442
Score = 223 bits (569), Expect = 2e-58
Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 150
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
Query: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
Query: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
Query: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
>gi|71725339 hepatocyte nuclear factor 4 alpha isoform d [Homo
sapiens]
Length = 452
Score = 223 bits (569), Expect = 2e-58
Identities = 129/337 (38%), Positives = 194/337 (57%), Gaps = 17/337 (5%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 150
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
Query: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
Query: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
Query: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPY 410
+ +IEQ+ F++L G I+ L+++MLL GS + P+
Sbjct: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPH 362
>gi|31077209 hepatocyte nuclear factor 4 alpha isoform c [Homo
sapiens]
Length = 417
Score = 220 bits (561), Expect = 2e-57
Identities = 127/330 (38%), Positives = 190/330 (57%), Gaps = 17/330 (5%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 60 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 119
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 120 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 172
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 173 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 231
Query: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 232 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 287
Query: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 288 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 347
Query: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSG 403
+ +IEQ+ F++L G I+ L+++MLL G
Sbjct: 348 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 377
>gi|71725336 hepatocyte nuclear factor 4 alpha isoform f [Homo
sapiens]
Length = 395
Score = 220 bits (561), Expect = 2e-57
Identities = 127/330 (38%), Positives = 190/330 (57%), Gaps = 17/330 (5%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RSVR+N Y+CR +R C +D+ RNQC+YCRLKK
Sbjct: 38 CAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKK 97
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + ++ +L + + L LS I+ P S
Sbjct: 98 CFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQIT-------SPVSGI 150
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
++ I I ++CE L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 151 NGD-IRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 209
Query: 257 AAQCSMPLHVAPLLA---AAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYS 313
A + SM LL H ++ V+ IRI E V + L +D EY+
Sbjct: 210 ATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVS----IRILDELVLPFQELQIDDNEYA 265
Query: 314 CLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTV 373
LKAI+ F DA GLSD ++ L+ + Q +LE+Y+ + + RFG+LLL LP+L+++
Sbjct: 266 YLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSI 325
Query: 374 SSSVIEQLFFVRLVGKTPIETLIRDMLLSG 403
+ +IEQ+ F++L G I+ L+++MLL G
Sbjct: 326 TWQMIEQIQFIKLFGMAKIDNLLQEMLLGG 355
>gi|115583654 hepatocyte nuclear factor 4, gamma [Homo sapiens]
Length = 445
Score = 218 bits (556), Expect = 6e-57
Identities = 123/329 (37%), Positives = 194/329 (58%), Gaps = 12/329 (3%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C +CGD+++GKHYG +C+GCK FF+RS+R++ Y+CR +R C +D+ RNQC+YCRL+K
Sbjct: 49 CAICGDRATGKHYGASSCDGCKGFFRRSIRKSHVYSCRFSRQCVVDKDKRNQCRYCRLRK 108
Query: 139 CLKVGMRREAVQ--RGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRF 196
C + GM++EAVQ R R+ + T + + + L S IS+ +S
Sbjct: 109 CFRAGMKKEAVQNERDRISTRRSTFDGSNIPSINTLAQAEVRSRQISV--------SSPG 160
Query: 197 GSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLN 256
S + I I ++CE + L VEWA+ IP F +L + DQVALLR E +L
Sbjct: 161 SSTDINVKKIASIGDVCESMKQQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLG 220
Query: 257 AAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLK 316
A + SM ++ LL S + ++ + + R+ E V + + +D EY+CLK
Sbjct: 221 ATKRSM-MYKDILLLGNNYVIHRNSCEVEISRVAN-RVLDELVRPFQEIQIDDNEYACLK 278
Query: 317 AIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSS 376
AIV F DA GLSD +++++ + Q LE+Y+ + + RFG+LLL LP+L++++
Sbjct: 279 AIVFFDPDAKGLSDPVKIKNMRFQVQIGLEDYINDRQYDSRGRFGELLLLLPTLQSITWQ 338
Query: 377 VIEQLFFVRLVGKTPIETLIRDMLLSGSS 405
+IEQ+ FV+L G I+ L+++MLL G+S
Sbjct: 339 MIEQIQFVKLFGMVKIDNLLQEMLLGGAS 367
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 195 bits (496), Expect = 6e-50
Identities = 112/329 (34%), Positives = 170/329 (51%), Gaps = 9/329 (2%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 103 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 162
Query: 139 CLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPL-------NCHSYLSGYISLLLRAEPY 191
CLKVGM +E V+ R+ + + + + P L+ +S LL AEP
Sbjct: 163 CLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPD 222
Query: 192 PTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251
M +I + +C+LA R L + WA++IP F L + DQ++LL+ W E
Sbjct: 223 KLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWME 282
Query: 252 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 311
+ +L S+P L A + R+ ++ R + V + K L V+ E
Sbjct: 283 ILILGIVYRSLPYD--DKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEE 340
Query: 312 YSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLR 371
+ LKA+ L SD+ + D+ V+ LQ+ AL++Y SQ +P R GKLLL LP LR
Sbjct: 341 FVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLR 400
Query: 372 TVSSSVIEQLFFVRLVGKTPIETLIRDML 400
++ ++ + V+L GK P+ L +ML
Sbjct: 401 QTAAKAVQHFYSVKLQGKVPMHKLFLEML 429
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 191 bits (486), Expect = 8e-49
Identities = 110/329 (33%), Positives = 169/329 (51%), Gaps = 9/329 (2%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 164
Query: 139 CLKVGMRREAVQRGRM-PPTQPTHGQFALTNGDPLN------CHSYLSGYISLLLRAEPY 191
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 165 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 224
Query: 192 PTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251
+ ++I + +C+LA R L + WA++IP F L + DQ++LL+ W E
Sbjct: 225 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 284
Query: 252 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 311
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 285 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 342
Query: 312 YSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLR 371
+ LKAI L SD+ + DV V+ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 372 TVSSSVIEQLFFVRLVGKTPIETLIRDML 400
S+ ++ + ++L GK P+ L +ML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 191 bits (486), Expect = 8e-49
Identities = 110/329 (33%), Positives = 169/329 (51%), Gaps = 9/329 (2%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 164
Query: 139 CLKVGMRREAVQRGRM-PPTQPTHGQFALTNGDPLN------CHSYLSGYISLLLRAEPY 191
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 165 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 224
Query: 192 PTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251
+ ++I + +C+LA R L + WA++IP F L + DQ++LL+ W E
Sbjct: 225 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 284
Query: 252 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 311
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 285 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 342
Query: 312 YSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLR 371
+ LKAI L SD+ + DV V+ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 372 TVSSSVIEQLFFVRLVGKTPIETLIRDML 400
S+ ++ + ++L GK P+ L +ML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 191 bits (486), Expect = 8e-49
Identities = 110/329 (33%), Positives = 169/329 (51%), Gaps = 9/329 (2%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 128 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 187
Query: 139 CLKVGMRREAVQRGRM-PPTQPTHGQFALTNGDPLN------CHSYLSGYISLLLRAEPY 191
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 188 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 247
Query: 192 PTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251
+ ++I + +C+LA R L + WA++IP F L + DQ++LL+ W E
Sbjct: 248 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 307
Query: 252 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 311
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 308 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 365
Query: 312 YSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLR 371
+ LKAI L SD+ + DV V+ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 366 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 425
Query: 372 TVSSSVIEQLFFVRLVGKTPIETLIRDML 400
S+ ++ + ++L GK P+ L +ML
Sbjct: 426 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 454
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 191 bits (486), Expect = 8e-49
Identities = 110/329 (33%), Positives = 169/329 (51%), Gaps = 9/329 (2%)
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C+VCGD +SG HYG +CE CK+FFKR+++ N+ Y+C A C I + R CQ CR K
Sbjct: 105 CLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMK 164
Query: 139 CLKVGMRREAVQRGRM-PPTQPTHGQFALTNGDPLN------CHSYLSGYISLLLRAEPY 191
CLKVGM +E V+ R+ Q + N LN + +S LL AEP
Sbjct: 165 CLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPE 224
Query: 192 PTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSE 251
+ ++I + +C+LA R L + WA++IP F L + DQ++LL+ W E
Sbjct: 225 KIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWME 284
Query: 252 LFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAE 311
+ +L S L L A + ++ +D + V+K K++ ++ E
Sbjct: 285 ILILGVVYRS--LSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEE 342
Query: 312 YSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLR 371
+ LKAI L SD+ + DV V+ LQ+ AL++Y Q+ P R GK+L+ LP LR
Sbjct: 343 FVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLR 402
Query: 372 TVSSSVIEQLFFVRLVGKTPIETLIRDML 400
S+ ++ + ++L GK P+ L +ML
Sbjct: 403 QTSTKAVQHFYNIKLEGKVPMHKLFLEML 431
>gi|18860920 estrogen-related receptor alpha [Homo sapiens]
Length = 423
Score = 185 bits (470), Expect = 6e-47
Identities = 132/418 (31%), Positives = 194/418 (46%), Gaps = 34/418 (8%)
Query: 14 EVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQG-GPASTPAQTAAG------GQG-GPGG 65
+V G + P P P G+ T P P P + G G+G GPG
Sbjct: 4 QVVGIEPLYIKAEPASPDSPKGSSETETEPPVALAPGPAPTRCLPGHKEEEDGEGAGPGE 63
Query: 66 PGSDKQQQQQHIE--CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPI 123
G K + C+VCGD +SG HYG +CE CK+FFKR+++ ++ Y+C A+ C I
Sbjct: 64 QGGGKLVLSSLPKRLCLVCGDVASGYHYGVASCEACKAFFKRTIQGSIEYSCPASNECEI 123
Query: 124 DQHHRNQCQYCRLKKCLKVGMRREAVQ----RG------RMPPTQP-------THGQFAL 166
+ R CQ CR KCL+VGM +E V+ RG R P P G A+
Sbjct: 124 TKRRRKACQACRFTKCLRVGMLKEGVRLDRVRGGRQKYKRRPEVDPLPFPGPFPAGPLAV 183
Query: 167 TNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEW 226
G P + ++ +S LL EP ++ + +C+L R + + W
Sbjct: 184 AGG-PRKTAAPVNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLCDLFDREIVVTISW 242
Query: 227 ARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVV 286
A++IP F L ++DQ+++L+ W E+ VL AQ S+PL LA A R
Sbjct: 243 AKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQ--DELAFAEDLVLDEEGARAA 300
Query: 287 AFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALE 346
+ + V +L+AL ++ EY LKA+ L SD+ + D VE L+E AL
Sbjct: 301 GLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALL 360
Query: 347 EYVRSQY----PNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 400
EY + + R G+LLL LP LR + V+ + V+L GK P+ L +ML
Sbjct: 361 EYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEML 418
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 177 bits (448), Expect = 2e-44
Identities = 127/401 (31%), Positives = 187/401 (46%), Gaps = 35/401 (8%)
Query: 19 QGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIE 78
+G S PG P +PH + G TP + G PGG
Sbjct: 220 EGESYSMPTAFPGLAPTSPHLEGS----GILDTPVTSTKARSGAPGGSEG---------R 266
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C VCGD +S +HYG TCEGCK FFKR+V++N Y C AN++CP+D+ RN+CQ+CR +K
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 139 CLKVGMRREAVQ-------RGRMP--PTQPTHGQFALTNGDPLNCHSYLSGYISLL--LR 187
CL VGM +E V+ RGR+P P QP A + H + L +
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSK 386
Query: 188 AEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRL 247
+ FG + + ++ +L + L +WA IP F +L DQ LL
Sbjct: 387 FQELVLPHFGKE-----DAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLES 441
Query: 248 TWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHV 307
+ ELF+L A S P L+ +GL + R F D I L +L V
Sbjct: 442 AFLELFILRLAYRSKP-GEGKLIFCSGLVLHRLQCAR--GFGDWIDSILAFSRSLHSLLV 498
Query: 308 DSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVR--SQYPNQPTRFGKLLL 365
D ++CL A+VL T D GL + VE LQ + L+E+V + P + +LL
Sbjct: 499 DVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG 557
Query: 366 RLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSF 406
+LP LRT+ + ++++F+++L P +I + + F
Sbjct: 558 KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 177 bits (448), Expect = 2e-44
Identities = 127/401 (31%), Positives = 187/401 (46%), Gaps = 35/401 (8%)
Query: 19 QGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIE 78
+G S PG P +PH + G TP + G PGG
Sbjct: 220 EGESYSMPTAFPGLAPTSPHLEGS----GILDTPVTSTKARSGAPGGSEG---------R 266
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C VCGD +S +HYG TCEGCK FFKR+V++N Y C AN++CP+D+ RN+CQ+CR +K
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 139 CLKVGMRREAVQ-------RGRMP--PTQPTHGQFALTNGDPLNCHSYLSGYISLL--LR 187
CL VGM +E V+ RGR+P P QP A + H + L +
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSK 386
Query: 188 AEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRL 247
+ FG + + ++ +L + L +WA IP F +L DQ LL
Sbjct: 387 FQELVLPHFGKE-----DAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLES 441
Query: 248 TWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHV 307
+ ELF+L A S P L+ +GL + R F D I L +L V
Sbjct: 442 AFLELFILRLAYRSKP-GEGKLIFCSGLVLHRLQCAR--GFGDWIDSILAFSRSLHSLLV 498
Query: 308 DSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVR--SQYPNQPTRFGKLLL 365
D ++CL A+VL T D GL + VE LQ + L+E+V + P + +LL
Sbjct: 499 DVPAFACLSALVLIT-DRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLG 557
Query: 366 RLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSF 406
+LP LRT+ + ++++F+++L P +I + + F
Sbjct: 558 KLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF 598
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 172 bits (437), Expect = 4e-43
Identities = 132/410 (32%), Positives = 196/410 (47%), Gaps = 33/410 (8%)
Query: 14 EVPGSQGSQASQAPPVPGPPPGAPHTPQTPG-QGGPASTPAQTAAGGQGGPGGPGSDKQQ 72
E GS Q VP P P + PG Q G AS T G P ++
Sbjct: 205 EPAGSHHVVDGQTFAVPNPIR-KPASMGFPGLQIGHASQLLDTQVPSPPSRGSPSNEGL- 262
Query: 73 QQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQ 132
C VCGD ++ +HYG TCEGCK FFKR+V++N Y C AN+NCP+D+ RN+CQ
Sbjct: 263 ------CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQ 316
Query: 133 YCRLKKCLKVGMRREAV-------QRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLL 185
YCR +KCL VGM +E V +RGR+ P++P Q P+ S +S +
Sbjct: 317 YCRFQKCLAVGMVKEVVRTDSLKGRRGRL-PSKPKSPQEPSPPSPPV---SLISALVRAH 372
Query: 186 LRAEPYPT----SRFGSQ---CMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQI 238
+ + P T SRF + M ++ I+ +L + WA IP F DL
Sbjct: 373 VDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPK 432
Query: 239 TDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQ 298
DQ L + ELFVL A S P+ L+ G+ + R F + I E
Sbjct: 433 ADQDLLFESAFLELFVLRLAYRSNPVE-GKLIFCNGVVLHRLQCVR--GFGEWIDSIVEF 489
Query: 299 VEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYV--RSQYPNQ 356
L+ +++D + +SC+ A+ + T + GL + VE LQ K L+++V + N+
Sbjct: 490 SSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNR 548
Query: 357 PTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSF 406
P KLL +LP LRT+ + ++++F+++L P +I + L F
Sbjct: 549 PNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF 598
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 166 bits (421), Expect = 3e-41
Identities = 120/402 (29%), Positives = 190/402 (47%), Gaps = 40/402 (9%)
Query: 31 GPPPGAPHTPQTPGQGGP--------ASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVC 82
G PP +P G G P S Q+ + + P P S + + C VC
Sbjct: 35 GSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSP-SPPPPPRVYKPCFVC 93
Query: 83 GDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKV 142
DKSSG HYG +CEGCK FF+RS+++N+ YTC ++NC I++ RN+CQYCRL+KC +V
Sbjct: 94 NDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEV 153
Query: 143 GMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRA--EPYPT----SRF 196
GM +EAV+ R + + + D L I+ + +A E +P+ ++
Sbjct: 154 GMSKEAVRNDRNKKKKEVKEE---GSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKY 210
Query: 197 GSQCMQPNNI---MGI-ENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSEL 252
+ + + +G+ + ELA + + VE+A+ +P F L I DQ+ LL+ ++
Sbjct: 211 TTNSSADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDI 270
Query: 253 FVLNAA------QCSMPLHVAPLLAAAGLHASPMS--ADRVVAFMDHIRIFQEQVEKLKA 304
+L Q +M L +H + D V AF +L
Sbjct: 271 LMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAF----------AGQLLP 320
Query: 305 LHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLL 364
L +D E L AI L D L + V+ LQE AL Y R + P+QP F ++L
Sbjct: 321 LEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRML 380
Query: 365 LRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSF 406
+++ LR +S+ E+ +++ P+ LIR+ML + F
Sbjct: 381 MKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMF 422
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 163 bits (412), Expect = 3e-40
Identities = 124/398 (31%), Positives = 191/398 (47%), Gaps = 36/398 (9%)
Query: 27 PPVPG--PPPGAPHT--PQTPGQG----GPASTPAQTAAGGQGGPGGPGSDKQQQQQHIE 78
PP+ G PPGA T Q P G PA+ Q+++ + P P S + +
Sbjct: 29 PPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPP-SPPPLPRIYKP 87
Query: 79 CVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKK 138
C VC DKSSG HYG CEGCK FF+RS+++N+ YTC ++NC I++ RN+CQYCRL+K
Sbjct: 88 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 147
Query: 139 CLKVGMRREAVQRGRMP-----PTQPTHGQFALTN--GDPL-NCHSYLSGYISLLLRAEP 190
C +VGM +E+V+ R P + LT G+ + L +
Sbjct: 148 CFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGK 207
Query: 191 YPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWS 250
Y T+ Q + +I + EL+ + + VE+A+ +P F L I DQ+ LL+
Sbjct: 208 YTTNNSSEQRVS-LDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACL 266
Query: 251 ELFVLNAA------QCSMPLHVAPLLAAAGLHASPMS--ADRVVAFMDHIRIFQEQVEKL 302
++ +L Q +M L +H + D V AF +L
Sbjct: 267 DILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAF----------ANQL 316
Query: 303 KALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGK 362
L +D AE L AI L D L V+ LQE AL+ YVR + P++P F K
Sbjct: 317 LPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPK 376
Query: 363 LLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 400
+L+++ LR++S+ E++ +++ + LI++ML
Sbjct: 377 MLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,227,837
Number of Sequences: 37866
Number of extensions: 1119440
Number of successful extensions: 26882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 541
Number of HSP's successfully gapped in prelim test: 541
Number of HSP's that attempted gapping in prelim test: 11191
Number of HSP's gapped (non-prelim): 10924
length of query: 414
length of database: 18,247,518
effective HSP length: 105
effective length of query: 309
effective length of database: 14,271,588
effective search space: 4409920692
effective search space used: 4409920692
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.