Guide to the Human Genome
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Search of human proteins with 14149734

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]
         (489 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]         996   0.0  
gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]         996   0.0  
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa...   757   0.0  
gi|109627650 coronin 6 [Homo sapiens]                                 690   0.0  
gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]          659   0.0  
gi|209529711 coronin, actin binding protein, 2A [Homo sapiens]        422   e-118
gi|16554585 coronin, actin binding protein, 2A [Homo sapiens]         422   e-118
gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]        405   e-113
gi|168229161 coronin 7 [Homo sapiens]                                 235   8e-62
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    70   3e-12
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    70   3e-12
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    70   3e-12
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...    69   7e-12
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    69   1e-11
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    65   2e-10
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             64   3e-10
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]               63   7e-10
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]               63   7e-10
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom...    62   9e-10
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]               62   2e-09
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          61   3e-09
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          61   3e-09
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          61   3e-09
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            61   3e-09
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]              61   3e-09
gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]               61   3e-09
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              60   3e-09
gi|5902034 periodic tryptophan protein 1 [Homo sapiens]                60   6e-09
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     59   1e-08
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     59   1e-08

>gi|65787364 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score =  996 bits (2574), Expect = 0.0
 Identities = 489/489 (100%), Positives = 489/489 (100%)

Query: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60
           MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF
Sbjct: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60

Query: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120
           LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP
Sbjct: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120

Query: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180
           LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY
Sbjct: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180

Query: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS 240
           NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS
Sbjct: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS 240

Query: 241 RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE 300
           RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE
Sbjct: 241 RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE 300

Query: 301 PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ 360
           PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ
Sbjct: 301 PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ 360

Query: 361 DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA 420
           DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA
Sbjct: 361 DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA 420

Query: 421 PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480
           PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ
Sbjct: 421 PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480

Query: 481 LGRMENGDA 489
           LGRMENGDA
Sbjct: 481 LGRMENGDA 489


>gi|14149734 coronin, actin binding protein, 1B [Homo sapiens]
          Length = 489

 Score =  996 bits (2574), Expect = 0.0
 Identities = 489/489 (100%), Positives = 489/489 (100%)

Query: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60
           MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF
Sbjct: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60

Query: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120
           LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP
Sbjct: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120

Query: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180
           LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY
Sbjct: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180

Query: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS 240
           NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS
Sbjct: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFS 240

Query: 241 RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE 300
           RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE
Sbjct: 241 RMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEE 300

Query: 301 PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ 360
           PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ
Sbjct: 301 PPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQ 360

Query: 361 DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA 420
           DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA
Sbjct: 361 DDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMA 420

Query: 421 PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480
           PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ
Sbjct: 421 PGSSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQ 480

Query: 481 LGRMENGDA 489
           LGRMENGDA
Sbjct: 481 LGRMENGDA 489


>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
           sapiens]
          Length = 474

 Score =  757 bits (1954), Expect = 0.0
 Identities = 350/481 (72%), Positives = 415/481 (86%), Gaps = 10/481 (2%)

Query: 4   RKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVL 63
           R+VVRQSKFRHVFGQ VKNDQCY+DIRVSRVTWDS+FCAVNP+F+A+I+EASGGGAFLVL
Sbjct: 2   RRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVL 61

Query: 64  PLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTE 123
           PL KTGRIDK+YPTVCGHTGPVLDIDWCPHND+VIASGSEDCTVMVWQIPENGLT  LTE
Sbjct: 62  PLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTE 121

Query: 124 PVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVS 183
           PVV+LEGH+KRVGI+AWHPTARNVLLSAGCDN ++IWNVGT E L  LD +H D+IYNVS
Sbjct: 122 PVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVS 181

Query: 184 WNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMS 243
           WN NGSL C+A KDK VR+IDPR+  +VAE+EKAHEGARPMRAIFLADG VFTTGFSRMS
Sbjct: 182 WNRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMS 241

Query: 244 ERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPY 303
           ERQLALW+P+N++EP+AL E+D+SNG LLPFYDPDTS++Y+CGKGDSSIRYFEIT+E PY
Sbjct: 242 ERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPY 301

Query: 304 IHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDL 363
           +H+LNTF+SKEPQRGMG MPKRGL+V+KCEIARF+KLHERKCEPI+MTVPRKSDLFQDDL
Sbjct: 302 VHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDL 361

Query: 364 YPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPGS 423
           YPDTAGPEAALEAEEW  G++ADPILISL+  Y+P K RDLK+ ++N+L DS+P      
Sbjct: 362 YPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNIL-DSKPTANKKC 420

Query: 424 SHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQLGR 483
             +  P  TT  A               KL+E+++E+++++  +  Q +RI +LE+Q+ +
Sbjct: 421 DLISIPKKTTDTASVQ---------NEAKLDEILKEIKSIKDTICNQDERISKLEQQMAK 471

Query: 484 M 484
           +
Sbjct: 472 I 472


>gi|109627650 coronin 6 [Homo sapiens]
          Length = 472

 Score =  690 bits (1780), Expect = 0.0
 Identities = 326/484 (67%), Positives = 392/484 (80%), Gaps = 16/484 (3%)

Query: 4   RKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVL 63
           R+VVRQSKFRHVFGQ  K DQ YEDIRVS+VTWDS+FCAVNPKFLA+IVEA GGGAF+VL
Sbjct: 3   RRVVRQSKFRHVFGQAAKADQAYEDIRVSKVTWDSSFCAVNPKFLAIIVEAGGGGAFIVL 62

Query: 64  PLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTE 123
           PL+KTGR+DK YP V GHT PVLDIDWCPHND VIAS S+D T+MVWQIP+      +TE
Sbjct: 63  PLAKTGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITE 122

Query: 124 PVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVS 183
           P++ LEGH+KRVGI++WHPTARNVLLSAG DNV++IWNVGT E L  LD +HPD+I++V 
Sbjct: 123 PIITLEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVC 182

Query: 184 WNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMS 243
           WN NGSL  + CKDK++RIIDPR+G +VAER  AHEG RPMRA+F   G +FTTGF+RMS
Sbjct: 183 WNSNGSLLATTCKDKTLRIIDPRKGQVVAERFAAHEGMRPMRAVFTRQGHIFTTGFTRMS 242

Query: 244 ERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPY 303
           +R+L LWDP N EEP+ALQE+D+SNG LLPFYDPD+S+VY+CGKGDSSIRYFEIT+EPP+
Sbjct: 243 QRELGLWDPNNFEEPVALQEMDTSNGVLLPFYDPDSSIVYLCGKGDSSIRYFEITDEPPF 302

Query: 304 IHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDL 363
           +H+LNTF+SKEPQRGMG MPKRGL+VSKCEIARFYKLHERKCEPI+MTVPRKSDLFQDDL
Sbjct: 303 VHYLNTFSSKEPQRGMGFMPKRGLDVSKCEIARFYKLHERKCEPIIMTVPRKSDLFQDDL 362

Query: 364 YPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPGS 423
           YPDT GPE ALEA+EW+SG+DA+P+LISLR+ YVP K R+L++++RN+L D RP   P  
Sbjct: 363 YPDTPGPEPALEADEWLSGQDAEPVLISLRDGYVPPKHRELRVTKRNIL-DVRPPSGPRR 421

Query: 424 SHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEEQLGR 483
           S                S S A   +   LE +++E++ALR  V+ Q  RI  LE  L  
Sbjct: 422 SQ---------------SASDAPLSQQHTLETLLEEIKALRERVQAQEQRITALENMLCE 466

Query: 484 MENG 487
           + +G
Sbjct: 467 LVDG 470


>gi|5902134 coronin, actin binding protein, 1A [Homo sapiens]
          Length = 461

 Score =  659 bits (1699), Expect = 0.0
 Identities = 316/477 (66%), Positives = 385/477 (80%), Gaps = 24/477 (5%)

Query: 4   RKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVL 63
           R+VVR SKFRHVFGQP K DQCYED+RVS+ TWDS FCAVNPKF+A+I EASGGGAFLVL
Sbjct: 3   RQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVL 62

Query: 64  PLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTE 123
           PL KTGR+DK  PTVCGHT PVLDI WCPHND VIASGSEDCTVMVW+IP+ GL  PL E
Sbjct: 63  PLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLRE 122

Query: 124 PVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLD-SLHPDLIYNV 182
           PVV LEGHTKRVGI+AWH TA+NVLLSAGCDNV+++W+VGT   +  L   +HPD IY+V
Sbjct: 123 PVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSV 182

Query: 183 SWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRM 242
            W+ +G L C++C+DK VRII+PR+GT+VAE+++ HEG RP+RA+F+++GK+ TTGFSRM
Sbjct: 183 DWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRM 242

Query: 243 SERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPP 302
           SERQ+ALWD ++LEEP++LQELD+S+G LLPF+DPDT++VY+CGKGDSSIRYFEIT E P
Sbjct: 243 SERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAP 302

Query: 303 YIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDD 362
           ++H+L+ F+SKE QRGMG MPKRGLEV+KCEIARFYKLHER+CEPI MTVPRKSDLFQ+D
Sbjct: 303 FLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQED 362

Query: 363 LYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLSDSRPAMAPG 422
           LYP TAGP+ AL AEEW+ GRDA P+LISL++ YVP K R+L+++R   L   R   AP 
Sbjct: 363 LYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRG--LDTGRRRAAP- 419

Query: 423 SSHLGAPASTTTAADATPSGSLARAGEAGKLEEVMQELRALRALVKEQGDRICRLEE 479
                  AS T ++DA             +LEE   E+R L+A V+E   R+ RLEE
Sbjct: 420 ------EASGTPSSDA-----------VSRLEE---EMRKLQATVQELQKRLDRLEE 456


>gi|209529711 coronin, actin binding protein, 2A [Homo sapiens]
          Length = 525

 Score =  422 bits (1086), Expect = e-118
 Identities = 215/454 (47%), Positives = 297/454 (65%), Gaps = 20/454 (4%)

Query: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60
           MS+    R SKFRHVFG+P   + CY+ + ++R   D+ FCAVNP F+AV+ E +GGGAF
Sbjct: 1   MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAF 60

Query: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120
           LV+PL +TG++D  YP VCGH G VLD+ W P +D  IAS SED T+ +W IP+  LT  
Sbjct: 61  LVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRN 120

Query: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLD----SLHP 176
           LT     L GH +RVG++ WHPTA N+L SAG D  V+IWN+ T E +        S H 
Sbjct: 121 LTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQ 180

Query: 177 DLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLAD-GKVF 235
           D+I ++S+N NGSL  + CKD+ +R+IDPR GT++  +E +++G R  + +FL +  K+ 
Sbjct: 181 DVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVL--QEASYKGHRASKVLFLGNLKKLM 238

Query: 236 TTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYF 295
           +TG SR + RQ+ALWD +NL  P+  ++LD S+G L PFYD DTS++YV GKGD +IRY+
Sbjct: 239 STGTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYY 298

Query: 296 EITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK--CEPIVMTVP 353
           E++ + P++ +L  + S  PQ+G+G MPKRGL+VS CEI RFYKL   K   EPI M VP
Sbjct: 299 EVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVP 358

Query: 354 RKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLS 413
           R+S+ +Q+D+YP TAG + +L A+EW+SG + DPIL+SLR           ++ R + L 
Sbjct: 359 RRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPG--------SELLRPHPLP 410

Query: 414 DSRP---AMAPGSSHLGAPASTTTAADATPSGSL 444
             RP   +MAP S  L        A D   S SL
Sbjct: 411 AERPIFNSMAPASPRLLNQTEKLAAEDGWRSSSL 444


>gi|16554585 coronin, actin binding protein, 2A [Homo sapiens]
          Length = 525

 Score =  422 bits (1086), Expect = e-118
 Identities = 215/454 (47%), Positives = 297/454 (65%), Gaps = 20/454 (4%)

Query: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60
           MS+    R SKFRHVFG+P   + CY+ + ++R   D+ FCAVNP F+AV+ E +GGGAF
Sbjct: 1   MSWHPQYRSSKFRHVFGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAF 60

Query: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120
           LV+PL +TG++D  YP VCGH G VLD+ W P +D  IAS SED T+ +W IP+  LT  
Sbjct: 61  LVIPLHQTGKLDPHYPKVCGHRGNVLDVKWNPFDDFEIASCSEDATIKIWSIPKQLLTRN 120

Query: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLD----SLHP 176
           LT     L GH +RVG++ WHPTA N+L SAG D  V+IWN+ T E +        S H 
Sbjct: 121 LTAYRKELVGHARRVGLVEWHPTAANILFSAGYDYKVMIWNLDTKESVITSPMSTISCHQ 180

Query: 177 DLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLAD-GKVF 235
           D+I ++S+N NGSL  + CKD+ +R+IDPR GT++  +E +++G R  + +FL +  K+ 
Sbjct: 181 DVILSMSFNTNGSLLATTCKDRKIRVIDPRAGTVL--QEASYKGHRASKVLFLGNLKKLM 238

Query: 236 TTGFSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYF 295
           +TG SR + RQ+ALWD +NL  P+  ++LD S+G L PFYD DTS++YV GKGD +IRY+
Sbjct: 239 STGTSRWNNRQVALWDQDNLSVPLMEEDLDGSSGVLFPFYDADTSMLYVVGKGDGNIRYY 298

Query: 296 EITEEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK--CEPIVMTVP 353
           E++ + P++ +L  + S  PQ+G+G MPKRGL+VS CEI RFYKL   K   EPI M VP
Sbjct: 299 EVSADKPHLSYLTEYRSYNPQKGIGVMPKRGLDVSSCEIFRFYKLITTKSLIEPISMIVP 358

Query: 354 RKSDLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLKISRRNVLS 413
           R+S+ +Q+D+YP TAG + +L A+EW+SG + DPIL+SLR           ++ R + L 
Sbjct: 359 RRSESYQEDIYPPTAGAQPSLTAQEWLSGMNRDPILVSLRPG--------SELLRPHPLP 410

Query: 414 DSRP---AMAPGSSHLGAPASTTTAADATPSGSL 444
             RP   +MAP S  L        A D   S SL
Sbjct: 411 AERPIFNSMAPASPRLLNQTEKLAAEDGWRSSSL 444


>gi|148529011 coronin, actin binding protein, 2B [Homo sapiens]
          Length = 480

 Score =  405 bits (1042), Expect = e-113
 Identities = 200/409 (48%), Positives = 278/409 (67%), Gaps = 8/409 (1%)

Query: 1   MSFRKVVRQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAF 60
           MS+R   R SKFR+V+G+    + C++ I +++   D+ FCAVN +FLA++ E++GGG+F
Sbjct: 6   MSWRPQYRSSKFRNVYGKVANREHCFDGIPITKNVHDNHFCAVNTRFLAIVTESAGGGSF 65

Query: 61  LVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSP 120
           LV+PL +TGRI+  YP VCGH G VLDI W P  D +IAS SED +V +W+IPE GL   
Sbjct: 66  LVIPLEQTGRIEPNYPKVCGHQGNVLDIKWNPFIDNIIASCSEDTSVRIWEIPEGGLKRN 125

Query: 121 LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIY 180
           +TE ++ L GH++RVG++ WHPT  N+L SAG D  VLIWN+   E +  +D  H D+I 
Sbjct: 126 MTEALLELHGHSRRVGLVEWHPTTNNILFSAGYDYKVLIWNLDVGEPVKMID-CHTDVIL 184

Query: 181 NVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAERE-KAHEGARPMRAIFLADGK-VFTTG 238
            +S+N +GSL  + CKDK +R+I+PR G ++ E   K H   R  R +FL + K + TTG
Sbjct: 185 CMSFNTDGSLLTTTCKDKKLRVIEPRSGRVLQEANCKNH---RVNRVVFLGNMKRLLTTG 241

Query: 239 FSRMSERQLALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEIT 298
            SR + RQ+ALWD E+L  P+  +E+D  +G L PFYD DT ++Y+ GKGD +IRY+EI+
Sbjct: 242 VSRWNTRQIALWDQEDLSMPLIEEEIDGLSGLLFPFYDADTHMLYLAGKGDGNIRYYEIS 301

Query: 299 EEPPYIHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERK--CEPIVMTVPRKS 356
            E PY+ +L  F S  PQ+G+G MPK GL+VS CE+ RFYKL   K   EPI M VPR+S
Sbjct: 302 TEKPYLSYLMEFRSPAPQKGLGVMPKHGLDVSACEVFRFYKLVTLKGLIEPISMIVPRRS 361

Query: 357 DLFQDDLYPDTAGPEAALEAEEWVSGRDADPILISLREAYVPSKQRDLK 405
           D +Q+D+YP T G E AL  +EW+ G + DP+L+SL+E Y  S +   K
Sbjct: 362 DSYQEDIYPMTPGTEPALTPDEWLGGINRDPVLMSLKEGYKKSSKMVFK 410


>gi|168229161 coronin 7 [Homo sapiens]
          Length = 925

 Score =  235 bits (599), Expect = 8e-62
 Identities = 138/392 (35%), Positives = 212/392 (54%), Gaps = 12/392 (3%)

Query: 10  SKFRHVFGQPVKNDQCYEDIRVSRVTWDST---FCAVNPKFLAVIVEASGGGAFLVLPLS 66
           SKFRH  G  +  D    +++   +T       FCA   K    +   S GG   VL L 
Sbjct: 471 SKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCA--NKLRVAVPLLSSGGQVAVLELR 528

Query: 67  KTGRI-DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPV 125
           K GR+ D A PT+  +   V D+ W P +   +A   ED  + +W++P  GL   LT P 
Sbjct: 529 KPGRLPDTALPTL-QNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPE 587

Query: 126 VVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWN 185
            VL GHT+++  + +HP A NVL S+  D  V IW++    +  +L   H D I++++W+
Sbjct: 588 TVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQG-HQDQIFSLAWS 646

Query: 186 HNGSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGK-VFTTGFSRMSE 244
            +G    + CKD  VR+  PR G    +     +G R  R +++ DG+ +  +GF   SE
Sbjct: 647 PDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSE 706

Query: 245 RQLALWDPENLEE-PMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPY 303
           RQL L++ E L   P+A+  LD +   LLP YDPDT +V + GKGD+ +  +E+  E P+
Sbjct: 707 RQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPF 766

Query: 304 IHFLNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPR-KSDLFQDD 362
               N+FTS +P +G+  +PK   +V + E+ R  +L +   EP+   +PR + + FQDD
Sbjct: 767 FLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDD 826

Query: 363 LYPDTAGP-EAALEAEEWVSGRDADPILISLR 393
           ++PDTA   E  L AE W+ G +  P L+SL+
Sbjct: 827 VFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQ 858



 Score =  205 bits (522), Expect = 7e-53
 Identities = 122/392 (31%), Positives = 201/392 (51%), Gaps = 6/392 (1%)

Query: 8   RQSKFRHVFGQPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSK 67
           R SKFRH   +P + +    DIR    T  S    +      +   +   G   ++PL  
Sbjct: 5   RVSKFRHTEARPPRRESWISDIRAG--TAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQG 62

Query: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
            G   +    +  H+  V D+D+ P +D ++A+GS D TV +W++P  G   P + P VV
Sbjct: 63  QGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALP-SAPGVV 121

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
           L      V ++ +HPT+  +L+SA     V +W+    + L  L + H DL+ +  W+ +
Sbjct: 122 LGPEDLPVEVLQFHPTSDGILVSAA-GTTVKVWDAAKQQPLTEL-AAHGDLVQSAVWSRD 179

Query: 188 GSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGK-VFTTGFSRMSERQ 246
           G+L  +ACKDK +RI DPR     ++  +AHE +R  R  ++   + + +TGF++M ER+
Sbjct: 180 GALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMRERE 239

Query: 247 LALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHF 306
           + LWD       +A   LD+S G L+P  DPD+ ++ + GKG+  +  +E+  + P +  
Sbjct: 240 VKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSP 299

Query: 307 LNTFTSKEPQRGMGSMPKRGLEVSKCEIARFYKLHERKCEPIVMTVPRKSDLFQDDLYPD 366
           +     +   RG   +P++ L V  CE+ R  +L +    PI   VPRK+  F +DL+PD
Sbjct: 300 VTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPD 359

Query: 367 TAGPEAALEAEEWVSGRDADPILISLREAYVP 398
           TAG   A +   W +G +     +SL  A  P
Sbjct: 360 TAGCVPATDPHSWWAGDNQQVQKVSLNPACRP 391


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 50/220 (22%), Positives = 100/220 (45%), Gaps = 12/220 (5%)

Query: 18  QPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLS---KTGRIDKA 74
           +P  + +C  D+R+     +    + NP     ++ AS      +  +S   K G++  A
Sbjct: 125 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 184

Query: 75  YPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKR 134
                GHT  V D+ W   ++ +  S ++D  +M+W    N  + P       ++ HT  
Sbjct: 185 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHS----VDAHTAE 240

Query: 135 VGIIAWHPTARNVLLSAGCDNVVLIWNVGTAE-ELYRLDSLHPDLIYNVSWN-HNGSLFC 192
           V  ++++P +  +L +   D  V +W++   + +L+  +S H D I+ V W+ HN ++  
Sbjct: 241 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-HKDEIFQVQWSPHNETILA 299

Query: 193 SACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADG 232
           S+  D+ + + D  +       E A +G  P   +F+  G
Sbjct: 300 SSGTDRRLNVWDLSKIGEEQSPEDAEDG--PPELLFIHGG 337



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 11/97 (11%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVW--------QIPENGLTSPLTEPVVVLEGHT 132
           H   +  + W PHN+ ++AS   D  + VW        Q PE+    P  E + +  GHT
Sbjct: 281 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP-PELLFIHGGHT 339

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELY 169
            ++   +W+P    V+ S   DN++ +W +  AE +Y
Sbjct: 340 AKISDFSWNPNEPWVICSVSEDNIMQVWQM--AENIY 374



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 44/213 (20%), Positives = 89/213 (41%), Gaps = 20/213 (9%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH      + W P+    + S S+D T+ +W I        + +   +  GHT  V  ++
Sbjct: 140 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 199

Query: 140 WHPTARNVLLSAGCDNVVLIWNV---GTAEELYRLDSLHPDLIYNVSWN-HNGSLFCSAC 195
           WH    ++  S   D  ++IW+     T++  + +D+ H   +  +S+N ++  +  +  
Sbjct: 200 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA-HTAEVNCLSFNPYSEFILATGS 258

Query: 196 KDKSVRIIDPRRGTLVAEREKAHEGA------RPMRAIFLADGKVFTTGFSRMSERQLAL 249
            DK+V + D R   L     ++H+         P     LA         S  ++R+L +
Sbjct: 259 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA---------SSGTDRRLNV 309

Query: 250 WDPENLEEPMALQELDSSNGALLPFYDPDTSVV 282
           WD   + E  + ++ +     LL  +   T+ +
Sbjct: 310 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 342



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 17/36 (47%), Positives = 21/36 (58%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN 115
           GHT  + D  W P+   VI S SED  + VWQ+ EN
Sbjct: 337 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 372


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 50/220 (22%), Positives = 100/220 (45%), Gaps = 12/220 (5%)

Query: 18  QPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLS---KTGRIDKA 74
           +P  + +C  D+R+     +    + NP     ++ AS      +  +S   K G++  A
Sbjct: 159 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 218

Query: 75  YPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKR 134
                GHT  V D+ W   ++ +  S ++D  +M+W    N  + P       ++ HT  
Sbjct: 219 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHS----VDAHTAE 274

Query: 135 VGIIAWHPTARNVLLSAGCDNVVLIWNVGTAE-ELYRLDSLHPDLIYNVSWN-HNGSLFC 192
           V  ++++P +  +L +   D  V +W++   + +L+  +S H D I+ V W+ HN ++  
Sbjct: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-HKDEIFQVQWSPHNETILA 333

Query: 193 SACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADG 232
           S+  D+ + + D  +       E A +G  P   +F+  G
Sbjct: 334 SSGTDRRLNVWDLSKIGEEQSPEDAEDG--PPELLFIHGG 371



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 11/97 (11%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVW--------QIPENGLTSPLTEPVVVLEGHT 132
           H   +  + W PHN+ ++AS   D  + VW        Q PE+    P  E + +  GHT
Sbjct: 315 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP-PELLFIHGGHT 373

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELY 169
            ++   +W+P    V+ S   DN++ +W +  AE +Y
Sbjct: 374 AKISDFSWNPNEPWVICSVSEDNIMQVWQM--AENIY 408



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 44/213 (20%), Positives = 89/213 (41%), Gaps = 20/213 (9%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH      + W P+    + S S+D T+ +W I        + +   +  GHT  V  ++
Sbjct: 174 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 233

Query: 140 WHPTARNVLLSAGCDNVVLIWNV---GTAEELYRLDSLHPDLIYNVSWN-HNGSLFCSAC 195
           WH    ++  S   D  ++IW+     T++  + +D+ H   +  +S+N ++  +  +  
Sbjct: 234 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA-HTAEVNCLSFNPYSEFILATGS 292

Query: 196 KDKSVRIIDPRRGTLVAEREKAHEGA------RPMRAIFLADGKVFTTGFSRMSERQLAL 249
            DK+V + D R   L     ++H+         P     LA         S  ++R+L +
Sbjct: 293 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA---------SSGTDRRLNV 343

Query: 250 WDPENLEEPMALQELDSSNGALLPFYDPDTSVV 282
           WD   + E  + ++ +     LL  +   T+ +
Sbjct: 344 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 376



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 17/36 (47%), Positives = 21/36 (58%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN 115
           GHT  + D  W P+   VI S SED  + VWQ+ EN
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 406


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 50/220 (22%), Positives = 100/220 (45%), Gaps = 12/220 (5%)

Query: 18  QPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLS---KTGRIDKA 74
           +P  + +C  D+R+     +    + NP     ++ AS      +  +S   K G++  A
Sbjct: 160 KPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDA 219

Query: 75  YPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKR 134
                GHT  V D+ W   ++ +  S ++D  +M+W    N  + P       ++ HT  
Sbjct: 220 KTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHS----VDAHTAE 275

Query: 135 VGIIAWHPTARNVLLSAGCDNVVLIWNVGTAE-ELYRLDSLHPDLIYNVSWN-HNGSLFC 192
           V  ++++P +  +L +   D  V +W++   + +L+  +S H D I+ V W+ HN ++  
Sbjct: 276 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFES-HKDEIFQVQWSPHNETILA 334

Query: 193 SACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADG 232
           S+  D+ + + D  +       E A +G  P   +F+  G
Sbjct: 335 SSGTDRRLNVWDLSKIGEEQSPEDAEDG--PPELLFIHGG 372



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 11/97 (11%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVW--------QIPENGLTSPLTEPVVVLEGHT 132
           H   +  + W PHN+ ++AS   D  + VW        Q PE+    P  E + +  GHT
Sbjct: 316 HKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGP-PELLFIHGGHT 374

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELY 169
            ++   +W+P    V+ S   DN++ +W +  AE +Y
Sbjct: 375 AKISDFSWNPNEPWVICSVSEDNIMQVWQM--AENIY 409



 Score = 49.3 bits (116), Expect = 8e-06
 Identities = 44/213 (20%), Positives = 89/213 (41%), Gaps = 20/213 (9%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH      + W P+    + S S+D T+ +W I        + +   +  GHT  V  ++
Sbjct: 175 GHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVS 234

Query: 140 WHPTARNVLLSAGCDNVVLIWNV---GTAEELYRLDSLHPDLIYNVSWN-HNGSLFCSAC 195
           WH    ++  S   D  ++IW+     T++  + +D+ H   +  +S+N ++  +  +  
Sbjct: 235 WHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDA-HTAEVNCLSFNPYSEFILATGS 293

Query: 196 KDKSVRIIDPRRGTLVAEREKAHEGA------RPMRAIFLADGKVFTTGFSRMSERQLAL 249
            DK+V + D R   L     ++H+         P     LA         S  ++R+L +
Sbjct: 294 ADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILA---------SSGTDRRLNV 344

Query: 250 WDPENLEEPMALQELDSSNGALLPFYDPDTSVV 282
           WD   + E  + ++ +     LL  +   T+ +
Sbjct: 345 WDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKI 377



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 17/36 (47%), Positives = 21/36 (58%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN 115
           GHT  + D  W P+   VI S SED  + VWQ+ EN
Sbjct: 372 GHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAEN 407


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 62/242 (25%), Positives = 103/242 (42%), Gaps = 15/242 (6%)

Query: 71  IDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEG 130
           I K    +  HT  V D+ + P    ++ S S D T+ VW + ++G        + VL G
Sbjct: 13  IGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG------NMMKVLRG 66

Query: 131 HTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSL 190
           H   V   A+ P + ++L S G    V +WN+     + +L+  H D++    ++ +G+L
Sbjct: 67  HQNWVYSCAFSPDS-SMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV-ACDFSPDGAL 124

Query: 191 FCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALW 250
             +A  D  V I DP  G ++ E         P+ A    D  V +  FS       +L 
Sbjct: 125 LATASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLA 184

Query: 251 DPE-----NLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIH 305
           D +      ++E   +Q    SNG    F   D SV+   G  D S+ ++    + P + 
Sbjct: 185 DDKMVRFWRIDEDYPVQVAPLSNGLCCAF-STDGSVL-AAGTHDGSVYFWATPRQVPSLQ 242

Query: 306 FL 307
            L
Sbjct: 243 HL 244


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 60/232 (25%), Positives = 100/232 (43%), Gaps = 15/232 (6%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140
           HT  V D+ + P    ++ S S D T+ VW + ++G        + VL GH   V   A+
Sbjct: 169 HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG------NMMKVLRGHQNWVYSCAF 222

Query: 141 HPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSV 200
            P + ++L S G    V +WN+     + +L+  H D++    ++ +G+L  +A  D  V
Sbjct: 223 SPDS-SMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVV-ACDFSPDGALLATASYDTRV 280

Query: 201 RIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPE-----NL 255
            I DP  G ++ E         P+ A    D  V +  FS       +L D +      +
Sbjct: 281 YIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVRFWRI 340

Query: 256 EEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEITEEPPYIHFL 307
           +E   +Q    SNG    F   D SV+   G  D S+ ++    + P +  L
Sbjct: 341 DEDYPVQVAPLSNGLCCAF-STDGSVL-AAGTHDGSVYFWATPRQVPSLQHL 390



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/158 (20%), Positives = 73/158 (46%), Gaps = 12/158 (7%)

Query: 97  VIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNV 156
           ++A+G  +  + +W +    L   L +       HT+ V  + + P    +L+SA  D  
Sbjct: 142 LLATGLNNGRIKIWDVYTGKLLLNLVD-------HTEVVRDLTFAPDGSLILVSASRDKT 194

Query: 157 VLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRRGTLVAEREK 216
           + +W++     + ++   H + +Y+ +++ + S+ CS    K+V + +  + T++ + E 
Sbjct: 195 LRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEG 254

Query: 217 AHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPEN 254
            H     +   F  DG +  T      + ++ +WDP N
Sbjct: 255 HHHDV--VACDFSPDGALLATA---SYDTRVYIWDPHN 287


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 51/181 (28%), Positives = 81/181 (44%), Gaps = 27/181 (14%)

Query: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
           TG   + +P    H+ P LD+DW  +N    AS S D  + V ++ ++        P+  
Sbjct: 297 TGEAKQQFPF---HSAPALDVDWQSNN--TFASCSTDMCIHVCKLGQD-------RPIKT 344

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
            +GHT  V  I W PT  N+L S   D  + IW++     ++ L + H   IY + W+  
Sbjct: 345 FQGHTNEVNAIKWDPTG-NLLASCSDDMTLKIWSMKQDNCVHDLQA-HNKEIYTIKWSPT 402

Query: 188 GS---------LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAI-FLADGKVFTT 237
           G          +  SA  D +VR+ D  RG  +    K  E   P+ ++ F  DG+   +
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQE---PVYSVAFSPDGRYLAS 459

Query: 238 G 238
           G
Sbjct: 460 G 460



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 43/138 (31%), Positives = 59/138 (42%), Gaps = 15/138 (10%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVV---VLEG-----H 131
           GH   V    W P +D ++ASGS D T  +W + EN  TS  T+ V+   + EG      
Sbjct: 167 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLSENS-TSGSTQLVLRHCIREGGQDVPS 224

Query: 132 TKRVGIIAWHPTARNVLLSAGC-DNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSL 190
            K V  + W+  +   LL+ G  D    IW       L      H   I+ + WN  G+ 
Sbjct: 225 NKDVTSLDWN--SEGTLLATGSYDGFARIWT--KDGNLASTLGQHKGPIFALKWNKKGNF 280

Query: 191 FCSACKDKSVRIIDPRRG 208
             SA  DK+  I D   G
Sbjct: 281 ILSAGVDKTTIIWDAHTG 298



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 42/185 (22%), Positives = 69/185 (37%), Gaps = 58/185 (31%)

Query: 72  DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGH 131
           D+   T  GHT  V  I W P  + ++AS S+D T+ +W + ++     L       + H
Sbjct: 339 DRPIKTFQGHTNEVNAIKWDPTGN-LLASCSDDMTLKIWSMKQDNCVHDL-------QAH 390

Query: 132 TKRVGIIAWHPT--------ARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVS 183
            K +  I W PT        A  +L SA  D+ V +W+V     ++ L   H + +Y+V+
Sbjct: 391 NKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTK-HQEPVYSVA 449

Query: 184 -----------------------------------------WNHNGSLFCSACKDKSVRI 202
                                                    WN  G    ++  D SV +
Sbjct: 450 FSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCV 509

Query: 203 IDPRR 207
           +D R+
Sbjct: 510 LDLRK 514



 Score = 37.7 bits (86), Expect = 0.024
 Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 16/120 (13%)

Query: 85  VLDIDWCPHNDE--VIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHP 142
           V  +DW   N E  ++A+GS D    +W   +  L S L +       H   +  + W+ 
Sbjct: 228 VTSLDW---NSEGTLLATGSYDGFARIWT-KDGNLASTLGQ-------HKGPIFALKWNK 276

Query: 143 TARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
              N +LSAG D   +IW+  T E   +    H     +V W  N + F S   D  + +
Sbjct: 277 KG-NFILSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQSNNT-FASCSTDMCIHV 333



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 14/90 (15%)

Query: 126 VVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GTAEELYR-------LD 172
           VVL GH   V I AW+P + ++L S   D+   IWN+      G+ + + R        D
Sbjct: 163 VVLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQD 221

Query: 173 SLHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
                 + ++ WN  G+L  +   D   RI
Sbjct: 222 VPSNKDVTSLDWNSEGTLLATGSYDGFARI 251


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 46/219 (21%), Positives = 96/219 (43%), Gaps = 10/219 (4%)

Query: 18  QPVKNDQCYEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLS---KTGRIDKA 74
           +P  + +C  D+R+     +    + N      ++ AS      +  ++   K G+I  A
Sbjct: 159 KPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDA 218

Query: 75  YPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKR 134
                GH+  V D+ W   ++ +  S ++D  +M+W    N      ++P  +++ HT  
Sbjct: 219 KAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSN----TTSKPSHLVDAHTAE 274

Query: 135 VGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWN-HNGSLFCS 193
           V  ++++P +  +L +   D  V +W++   +        H D I+ V W+ HN ++  S
Sbjct: 275 VNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILAS 334

Query: 194 ACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADG 232
           +  D+ + + D  +       E A +G  P   +F+  G
Sbjct: 335 SGTDRRLNVWDLSKIGEEQSAEDAEDG--PPELLFIHGG 371



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 26/96 (27%), Positives = 45/96 (46%), Gaps = 9/96 (9%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLT-------EPVVVLEGHTK 133
           H   +  + W PHN+ ++AS   D  + VW + + G             E + +  GHT 
Sbjct: 315 HKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTA 374

Query: 134 RVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELY 169
           ++   +W+P    V+ S   DN++ IW +  AE +Y
Sbjct: 375 KISDFSWNPNEPWVICSVSEDNIMQIWQM--AENIY 408



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 44/212 (20%), Positives = 84/212 (39%), Gaps = 18/212 (8%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH      + W  +    + S S+D TV +W I        + +   +  GH+  V  +A
Sbjct: 174 GHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVA 233

Query: 140 WHPTARNVLLSAGCDNVVLIWNV--GTAEELYRLDSLHPDLIYNVSWN-HNGSLFCSACK 196
           WH    ++  S   D  ++IW+    T  +   L   H   +  +S+N ++  +  +   
Sbjct: 234 WHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSA 293

Query: 197 DKSVRIIDPRRGTLVAEREKAHEGA------RPMRAIFLADGKVFTTGFSRMSERQLALW 250
           DK+V + D R   L     ++H+         P     LA         S  ++R+L +W
Sbjct: 294 DKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILA---------SSGTDRRLNVW 344

Query: 251 DPENLEEPMALQELDSSNGALLPFYDPDTSVV 282
           D   + E  + ++ +     LL  +   T+ +
Sbjct: 345 DLSKIGEEQSAEDAEDGPPELLFIHGGHTAKI 376



 Score = 38.5 bits (88), Expect = 0.014
 Identities = 16/36 (44%), Positives = 21/36 (58%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN 115
           GHT  + D  W P+   VI S SED  + +WQ+ EN
Sbjct: 371 GHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAEN 406


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 7/132 (5%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140
           H   V   DW  +N ++IA+G ED  V V+ +  +       +P+ V  GHT +V  + W
Sbjct: 496 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSS-----DQPLKVFSGHTAKVFHVKW 550

Query: 141 HPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN-GSLFCSACKDKS 199
            P    +L S   D  V IW+  T +    + + H   +  + WN     L  S   D +
Sbjct: 551 SPLREGILCSGSDDGTVRIWDY-TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYT 609

Query: 200 VRIIDPRRGTLV 211
           +++ D R GT V
Sbjct: 610 IKVWDTREGTCV 621



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 33/124 (26%), Positives = 55/124 (44%), Gaps = 7/124 (5%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH   + D  + P +  ++A+ S D T+ VW I  N LT+  T P     G+   +  ++
Sbjct: 367 GHVETIFDCKFKPDDPNLLATASFDGTIKVWDI--NTLTAVYTSP-----GNEGVIYSLS 419

Query: 140 WHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKS 199
           W P   N +      N   IWNV   + + R +    + I+ ++W+H  S   + C    
Sbjct: 420 WAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDG 479

Query: 200 VRII 203
             II
Sbjct: 480 FCII 483



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 33/135 (24%), Positives = 63/135 (46%), Gaps = 15/135 (11%)

Query: 72  DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGH 131
           D+      GHT  V  + W P  + ++ SGS+D TV +W   ++         + +L GH
Sbjct: 532 DQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC-------INILNGH 584

Query: 132 TKRVGIIAWHPTARNVLLSAGCDNVVLIWNV--GT-AEELYRLDSLHPDLIYNVSWNHNG 188
           T  V  + W+     +L+S   D  + +W+   GT  + +Y     H   +Y ++ + + 
Sbjct: 585 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD----HGADVYGLTCHPSR 640

Query: 189 SLFCSAC-KDKSVRI 202
               ++C +D +VR+
Sbjct: 641 PFTMASCSRDSTVRL 655



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 9/91 (9%)

Query: 73  KAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHT 132
           K +  +  H   +  I WCPHN ++ ASGS D  V++W + E        + V+     T
Sbjct: 50  KLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE--------QKVIAKLDST 101

Query: 133 KRV-GIIAWHPTARNVLLSAGCDNVVLIWNV 162
           K +   ++W   A +V+        + IW +
Sbjct: 102 KGIPASLSWCWNAEDVVAFVSHRGPLFIWTI 132



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 12/76 (15%)

Query: 127 VLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSW-- 184
           ++  H K +  I+W P   ++  S   DN+V+IWNV   + + +LDS    +  ++SW  
Sbjct: 54  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDST-KGIPASLSWCW 112

Query: 185 ---------NHNGSLF 191
                    +H G LF
Sbjct: 113 NAEDVVAFVSHRGPLF 128


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 62.8 bits (151), Expect = 7e-10
 Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 7/132 (5%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140
           H   V   DW  +N ++IA+G ED  V V+ +  +       +P+ V  GHT +V  + W
Sbjct: 520 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSS-----DQPLKVFSGHTAKVFHVKW 574

Query: 141 HPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN-GSLFCSACKDKS 199
            P    +L S   D  V IW+  T +    + + H   +  + WN     L  S   D +
Sbjct: 575 SPLREGILCSGSDDGTVRIWDY-TQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYT 633

Query: 200 VRIIDPRRGTLV 211
           +++ D R GT V
Sbjct: 634 IKVWDTREGTCV 645



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 33/124 (26%), Positives = 55/124 (44%), Gaps = 7/124 (5%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH   + D  + P +  ++A+ S D T+ VW I  N LT+  T P     G+   +  ++
Sbjct: 391 GHVETIFDCKFKPDDPNLLATASFDGTIKVWDI--NTLTAVYTSP-----GNEGVIYSLS 443

Query: 140 WHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKS 199
           W P   N +      N   IWNV   + + R +    + I+ ++W+H  S   + C    
Sbjct: 444 WAPGGLNCIAGGTSRNGAFIWNVQKGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDG 503

Query: 200 VRII 203
             II
Sbjct: 504 FCII 507



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 33/135 (24%), Positives = 63/135 (46%), Gaps = 15/135 (11%)

Query: 72  DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGH 131
           D+      GHT  V  + W P  + ++ SGS+D TV +W   ++         + +L GH
Sbjct: 556 DQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIWDYTQDAC-------INILNGH 608

Query: 132 TKRVGIIAWHPTARNVLLSAGCDNVVLIWNV--GT-AEELYRLDSLHPDLIYNVSWNHNG 188
           T  V  + W+     +L+S   D  + +W+   GT  + +Y     H   +Y ++ + + 
Sbjct: 609 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTREGTCVDTVYD----HGADVYGLTCHPSR 664

Query: 189 SLFCSAC-KDKSVRI 202
               ++C +D +VR+
Sbjct: 665 PFTMASCSRDSTVRL 679



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 24/91 (26%), Positives = 41/91 (45%), Gaps = 9/91 (9%)

Query: 73  KAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHT 132
           K +  +  H   +  I WCPHN ++ ASGS D  V++W + E        + V+     T
Sbjct: 74  KLHAIMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAE--------QKVIAKLDST 125

Query: 133 KRV-GIIAWHPTARNVLLSAGCDNVVLIWNV 162
           K +   ++W   A +V+        + IW +
Sbjct: 126 KGIPASLSWCWNAEDVVAFVSHRGPLFIWTI 156



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 12/76 (15%)

Query: 127 VLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSW-- 184
           ++  H K +  I+W P   ++  S   DN+V+IWNV   + + +LDS    +  ++SW  
Sbjct: 78  IMSEHKKTITAISWCPHNPDLFASGSTDNLVIIWNVAEQKVIAKLDST-KGIPASLSWCW 136

Query: 185 ---------NHNGSLF 191
                    +H G LF
Sbjct: 137 NAEDVVAFVSHRGPLF 152


>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
           sapiens]
          Length = 504

 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 52/230 (22%), Positives = 96/230 (41%), Gaps = 22/230 (9%)

Query: 75  YPTVCGHTG-------PVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
           Y  V  H G        +L +D CP +   I +G  D  V+V+      +       +  
Sbjct: 207 YRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQI-------LAT 259

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
           L+GHTK+V  + +HP +++++ SA  D  + IW+V  A    ++   H   +  +S +  
Sbjct: 260 LKGHTKKVTSVVFHP-SQDLVFSASPDATIRIWSVPNA-SCVQVVRAHESAVTGLSLHAT 317

Query: 188 GSLFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQL 247
           G    S+  D+     D + G ++ +      G     A F  DG +F TG     + Q+
Sbjct: 318 GDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHPDGLIFGTG---TMDSQI 374

Query: 248 ALWDPENLEEPMALQELDSSNGALLPFYDPDTSVVYVCGKGDSSIRYFEI 297
            +WD   L+E   +      +G +      +          DSS++ +++
Sbjct: 375 KIWD---LKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDL 421


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 42/156 (26%), Positives = 65/156 (41%), Gaps = 39/156 (25%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDC-----------------------TVMVWQIPENG 116
           GH   V  +DW P    ++ SGS+D                        TVM  ++  NG
Sbjct: 242 GHGADVKCVDWHP-TKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG 300

Query: 117 ---LTSP------------LTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWN 161
              LT+             L E + V  GH K    +AWHP    +  S G D  +L W+
Sbjct: 301 NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH 360

Query: 162 VGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKD 197
           VG  +E+  ++  H  +I++++W+  G + CS   D
Sbjct: 361 VGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSND 396



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 32/128 (25%), Positives = 56/128 (43%), Gaps = 12/128 (9%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140
           H   + +  + P  D   A+ S+D TV +W                +L GH   V  + W
Sbjct: 201 HKEAIREASFSP-TDNKFATCSDDGTVRIWDFLR-------CHEERILRGHGADVKCVDW 252

Query: 141 HPTARNVLLSAGCDN--VVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDK 198
           HPT + +++S   D+   +  W+  T + L  L + H + +  V  N NG+   +A +D 
Sbjct: 253 HPT-KGLVVSGSKDSQQPIKFWDPKTGQSLATLHA-HKNTVMEVKLNLNGNWLLTASRDH 310

Query: 199 SVRIIDPR 206
             ++ D R
Sbjct: 311 LCKLFDIR 318



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 20/81 (24%), Positives = 36/81 (44%), Gaps = 7/81 (8%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GH      + W P ++ + ASG  D +++ W +   G+   +    +  EG    +  +A
Sbjct: 329 GHKKEATAVAWHPVHEGLFASGGSDGSLLFWHV---GVEKEVGGMEMAHEG---MIWSLA 382

Query: 140 WHPTARNVLLSAGCDNVVLIW 160
           WHP   ++L S   D+    W
Sbjct: 383 WHPLG-HILCSGSNDHTSKFW 402


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 51/181 (28%), Positives = 77/181 (42%), Gaps = 27/181 (14%)

Query: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
           TG   + +P    H+ P LD+DW   N+   AS S D  + V ++           PV  
Sbjct: 309 TGEAKQQFPF---HSAPALDVDW--QNNTTFASCSTDMCIHVCRLG-------CDRPVKT 356

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
            +GHT  V  I W P+   +L S   D  + IW++     ++ L + H   IY + W+  
Sbjct: 357 FQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPT 414

Query: 188 GS---------LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAI-FLADGKVFTT 237
           G          +  SA  D +VR+ D  RG       K  E   P+ ++ F  DGK   +
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE---PVYSVAFSPDGKYLAS 471

Query: 238 G 238
           G
Sbjct: 472 G 472



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 40/136 (29%), Positives = 55/136 (40%), Gaps = 11/136 (8%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN---GLTSPLTEPVVVLEGH----T 132
           GH   V    W P +D ++ASGS D T  +W + EN   G T  +    +   GH     
Sbjct: 179 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFC 192
           K V  + W+ T   +L +   D    IW       L      H   I+ + WN  G+   
Sbjct: 238 KDVTSLDWN-TNGTLLATGSYDGFARIWT--EDGNLASTLGQHKGPIFALKWNRKGNYIL 294

Query: 193 SACKDKSVRIIDPRRG 208
           SA  DK+  I D   G
Sbjct: 295 SAGVDKTTIIWDAHTG 310



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 10/116 (8%)

Query: 92  PHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSA 151
           P+++ ++AS S D TV +W I     T  LT+       H + V  +A+ P  +  L S 
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTK-------HQEPVYSVAFSPDGK-YLASG 472

Query: 152 GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRR 207
             D  V IWN  +   ++         I+ V WN  G    ++  D SV ++D R+
Sbjct: 473 SFDKCVHIWNTQSGNLVHSYRGTGG--IFEVCWNARGDKVGASASDGSVCVLDLRK 526



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/127 (26%), Positives = 53/127 (41%), Gaps = 16/127 (12%)

Query: 80  GHTGP----VLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRV 135
           GH  P    V  +DW   N  ++A+GS D    +W   +  L S L +       H   +
Sbjct: 231 GHDVPSNKDVTSLDWNT-NGTLLATGSYDGFARIWT-EDGNLASTLGQ-------HKGPI 281

Query: 136 GIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSAC 195
             + W+    N +LSAG D   +IW+  T E   +    H     +V W +N + F S  
Sbjct: 282 FALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQNN-TTFASCS 338

Query: 196 KDKSVRI 202
            D  + +
Sbjct: 339 TDMCIHV 345



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 127 VLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GTAEELYR-------LDS 173
           VL GH   V I AW+P + ++L S   D+   IWN+      G+ + + R        D 
Sbjct: 176 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234

Query: 174 LHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
                + ++ WN NG+L  +   D   RI
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDGFARI 263


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 51/181 (28%), Positives = 77/181 (42%), Gaps = 27/181 (14%)

Query: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
           TG   + +P    H+ P LD+DW   N+   AS S D  + V ++           PV  
Sbjct: 309 TGEAKQQFPF---HSAPALDVDW--QNNTTFASCSTDMCIHVCRLG-------CDRPVKT 356

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
            +GHT  V  I W P+   +L S   D  + IW++     ++ L + H   IY + W+  
Sbjct: 357 FQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPT 414

Query: 188 GS---------LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAI-FLADGKVFTT 237
           G          +  SA  D +VR+ D  RG       K  E   P+ ++ F  DGK   +
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE---PVYSVAFSPDGKYLAS 471

Query: 238 G 238
           G
Sbjct: 472 G 472



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 40/136 (29%), Positives = 55/136 (40%), Gaps = 11/136 (8%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN---GLTSPLTEPVVVLEGH----T 132
           GH   V    W P +D ++ASGS D T  +W + EN   G T  +    +   GH     
Sbjct: 179 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 237

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFC 192
           K V  + W+ T   +L +   D    IW       L      H   I+ + WN  G+   
Sbjct: 238 KDVTSLDWN-TNGTLLATGSYDGFARIWT--EDGNLASTLGQHKGPIFALKWNRKGNYIL 294

Query: 193 SACKDKSVRIIDPRRG 208
           SA  DK+  I D   G
Sbjct: 295 SAGVDKTTIIWDAHTG 310



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 10/116 (8%)

Query: 92  PHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSA 151
           P+++ ++AS S D TV +W I     T  LT+       H + V  +A+ P  +  L S 
Sbjct: 421 PNSNIMLASASFDSTVRLWDIERGVCTHTLTK-------HQEPVYSVAFSPDGK-YLASG 472

Query: 152 GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRR 207
             D  V IWN  +   ++         I+ V WN  G    ++  D SV ++D R+
Sbjct: 473 SFDKCVHIWNTQSGNLVHSYRGTGG--IFEVCWNARGDKVGASASDGSVCVLDLRK 526



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/127 (26%), Positives = 53/127 (41%), Gaps = 16/127 (12%)

Query: 80  GHTGP----VLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRV 135
           GH  P    V  +DW   N  ++A+GS D    +W   +  L S L +       H   +
Sbjct: 231 GHDVPSNKDVTSLDWNT-NGTLLATGSYDGFARIWT-EDGNLASTLGQ-------HKGPI 281

Query: 136 GIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSAC 195
             + W+    N +LSAG D   +IW+  T E   +    H     +V W +N + F S  
Sbjct: 282 FALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQNN-TTFASCS 338

Query: 196 KDKSVRI 202
            D  + +
Sbjct: 339 TDMCIHV 345



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 127 VLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GTAEELYR-------LDS 173
           VL GH   V I AW+P + ++L S   D+   IWN+      G+ + + R        D 
Sbjct: 176 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234

Query: 174 LHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
                + ++ WN NG+L  +   D   RI
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDGFARI 263


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 51/181 (28%), Positives = 77/181 (42%), Gaps = 27/181 (14%)

Query: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
           TG   + +P    H+ P LD+DW   N+   AS S D  + V ++           PV  
Sbjct: 360 TGEAKQQFPF---HSAPALDVDW--QNNTTFASCSTDMCIHVCRLG-------CDRPVKT 407

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
            +GHT  V  I W P+   +L S   D  + IW++     ++ L + H   IY + W+  
Sbjct: 408 FQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPT 465

Query: 188 GS---------LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAI-FLADGKVFTT 237
           G          +  SA  D +VR+ D  RG       K  E   P+ ++ F  DGK   +
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE---PVYSVAFSPDGKYLAS 522

Query: 238 G 238
           G
Sbjct: 523 G 523



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 40/136 (29%), Positives = 55/136 (40%), Gaps = 11/136 (8%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN---GLTSPLTEPVVVLEGH----T 132
           GH   V    W P +D ++ASGS D T  +W + EN   G T  +    +   GH     
Sbjct: 230 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFC 192
           K V  + W+ T   +L +   D    IW       L      H   I+ + WN  G+   
Sbjct: 289 KDVTSLDWN-TNGTLLATGSYDGFARIWT--EDGNLASTLGQHKGPIFALKWNRKGNYIL 345

Query: 193 SACKDKSVRIIDPRRG 208
           SA  DK+  I D   G
Sbjct: 346 SAGVDKTTIIWDAHTG 361



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 10/116 (8%)

Query: 92  PHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSA 151
           P+++ ++AS S D TV +W I     T  LT+       H + V  +A+ P  +  L S 
Sbjct: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTK-------HQEPVYSVAFSPDGK-YLASG 523

Query: 152 GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRR 207
             D  V IWN  +   ++         I+ V WN  G    ++  D SV ++D R+
Sbjct: 524 SFDKCVHIWNTQSGNLVHSYRGTGG--IFEVCWNARGDKVGASASDGSVCVLDLRK 577



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/127 (26%), Positives = 53/127 (41%), Gaps = 16/127 (12%)

Query: 80  GHTGP----VLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRV 135
           GH  P    V  +DW   N  ++A+GS D    +W   +  L S L +       H   +
Sbjct: 282 GHDVPSNKDVTSLDWNT-NGTLLATGSYDGFARIWT-EDGNLASTLGQ-------HKGPI 332

Query: 136 GIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSAC 195
             + W+    N +LSAG D   +IW+  T E   +    H     +V W +N + F S  
Sbjct: 333 FALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQNN-TTFASCS 389

Query: 196 KDKSVRI 202
            D  + +
Sbjct: 390 TDMCIHV 396



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 127 VLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GTAEELYR-------LDS 173
           VL GH   V I AW+P + ++L S   D+   IWN+      G+ + + R        D 
Sbjct: 227 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285

Query: 174 LHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
                + ++ WN NG+L  +   D   RI
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARI 314


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 51/181 (28%), Positives = 77/181 (42%), Gaps = 27/181 (14%)

Query: 68  TGRIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVV 127
           TG   + +P    H+ P LD+DW   N+   AS S D  + V ++           PV  
Sbjct: 360 TGEAKQQFPF---HSAPALDVDW--QNNTTFASCSTDMCIHVCRLG-------CDRPVKT 407

Query: 128 LEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHN 187
            +GHT  V  I W P+   +L S   D  + IW++     ++ L + H   IY + W+  
Sbjct: 408 FQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQA-HNKEIYTIKWSPT 465

Query: 188 GS---------LFCSACKDKSVRIIDPRRGTLVAEREKAHEGARPMRAI-FLADGKVFTT 237
           G          +  SA  D +VR+ D  RG       K  E   P+ ++ F  DGK   +
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE---PVYSVAFSPDGKYLAS 522

Query: 238 G 238
           G
Sbjct: 523 G 523



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 40/136 (29%), Positives = 55/136 (40%), Gaps = 11/136 (8%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN---GLTSPLTEPVVVLEGH----T 132
           GH   V    W P +D ++ASGS D T  +W + EN   G T  +    +   GH     
Sbjct: 230 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 288

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFC 192
           K V  + W+ T   +L +   D    IW       L      H   I+ + WN  G+   
Sbjct: 289 KDVTSLDWN-TNGTLLATGSYDGFARIWT--EDGNLASTLGQHKGPIFALKWNRKGNYIL 345

Query: 193 SACKDKSVRIIDPRRG 208
           SA  DK+  I D   G
Sbjct: 346 SAGVDKTTIIWDAHTG 361



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 33/116 (28%), Positives = 53/116 (45%), Gaps = 10/116 (8%)

Query: 92  PHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSA 151
           P+++ ++AS S D TV +W I     T  LT+       H + V  +A+ P  +  L S 
Sbjct: 472 PNSNIMLASASFDSTVRLWDIERGVCTHTLTK-------HQEPVYSVAFSPDGK-YLASG 523

Query: 152 GCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACKDKSVRIIDPRR 207
             D  V IWN  +   ++         I+ V WN  G    ++  D SV ++D R+
Sbjct: 524 SFDKCVHIWNTQSGNLVHSYRGTGG--IFEVCWNARGDKVGASASDGSVCVLDLRK 577



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/127 (26%), Positives = 53/127 (41%), Gaps = 16/127 (12%)

Query: 80  GHTGP----VLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRV 135
           GH  P    V  +DW   N  ++A+GS D    +W   +  L S L +       H   +
Sbjct: 282 GHDVPSNKDVTSLDWNT-NGTLLATGSYDGFARIWT-EDGNLASTLGQ-------HKGPI 332

Query: 136 GIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSAC 195
             + W+    N +LSAG D   +IW+  T E   +    H     +V W +N + F S  
Sbjct: 333 FALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQNN-TTFASCS 389

Query: 196 KDKSVRI 202
            D  + +
Sbjct: 390 TDMCIHV 396



 Score = 35.4 bits (80), Expect = 0.12
 Identities = 26/89 (29%), Positives = 40/89 (44%), Gaps = 14/89 (15%)

Query: 127 VLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GTAEELYR-------LDS 173
           VL GH   V I AW+P + ++L S   D+   IWN+      G+ + + R        D 
Sbjct: 227 VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285

Query: 174 LHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
                + ++ WN NG+L  +   D   RI
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARI 314


>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
          Length = 498

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 34/96 (35%), Positives = 55/96 (57%), Gaps = 6/96 (6%)

Query: 98  IASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNV- 156
           +A+GS+D TV++WQ+  +   + L + +  LEGH   V  IAW P   N L++ G D+  
Sbjct: 207 LATGSKDTTVIIWQVDPD---THLLKLLKTLEGHAYGVSYIAWSPDD-NYLVACGPDDCS 262

Query: 157 -VLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLF 191
            + +WNV T E   ++   H D + +V+WN +G  F
Sbjct: 263 ELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRF 298



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 27/68 (39%), Positives = 38/68 (55%), Gaps = 7/68 (10%)

Query: 93  HNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAG 152
           HN++ IASGSED  V +W        S L  P+  L GHT+ V  ++W+P   +++ SA 
Sbjct: 418 HNEDFIASGSEDHKVYIWH-----KRSEL--PIAELTGHTRTVNCVSWNPQIPSMMASAS 470

Query: 153 CDNVVLIW 160
            D  V IW
Sbjct: 471 DDGTVRIW 478



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 18/74 (24%), Positives = 36/74 (48%), Gaps = 7/74 (9%)

Query: 73  KAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCT-VMVWQIPENGLTSPLTEPVVVLEGH 131
           K   T+ GH   V  I W P ++ ++A G +DC+ + +W +    L + ++      + H
Sbjct: 229 KLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMS------QSH 282

Query: 132 TKRVGIIAWHPTAR 145
              +  +AW+P  +
Sbjct: 283 EDSLTSVAWNPDGK 296



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 7/85 (8%)

Query: 26  YEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPV 85
           Y+ +     T  S F   N  F+A     SG     V    K   +  A  T  GHT  V
Sbjct: 401 YQGVTQGFYTIHSCFGGHNEDFIA-----SGSEDHKVYIWHKRSELPIAELT--GHTRTV 453

Query: 86  LDIDWCPHNDEVIASGSEDCTVMVW 110
             + W P    ++AS S+D TV +W
Sbjct: 454 NCVSWNPQIPSMMASASDDGTVRIW 478


>gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]
          Length = 514

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 34/96 (35%), Positives = 55/96 (57%), Gaps = 6/96 (6%)

Query: 98  IASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNV- 156
           +A+GS+D TV++WQ+  +   + L + +  LEGH   V  IAW P   N L++ G D+  
Sbjct: 223 LATGSKDTTVIIWQVDPD---THLLKLLKTLEGHAYGVSYIAWSPDD-NYLVACGPDDCS 278

Query: 157 -VLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLF 191
            + +WNV T E   ++   H D + +V+WN +G  F
Sbjct: 279 ELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRF 314



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 27/68 (39%), Positives = 38/68 (55%), Gaps = 7/68 (10%)

Query: 93  HNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAG 152
           HN++ IASGSED  V +W        S L  P+  L GHT+ V  ++W+P   +++ SA 
Sbjct: 434 HNEDFIASGSEDHKVYIWH-----KRSEL--PIAELTGHTRTVNCVSWNPQIPSMMASAS 486

Query: 153 CDNVVLIW 160
            D  V IW
Sbjct: 487 DDGTVRIW 494



 Score = 35.0 bits (79), Expect = 0.15
 Identities = 18/74 (24%), Positives = 36/74 (48%), Gaps = 7/74 (9%)

Query: 73  KAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCT-VMVWQIPENGLTSPLTEPVVVLEGH 131
           K   T+ GH   V  I W P ++ ++A G +DC+ + +W +    L + ++      + H
Sbjct: 245 KLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMS------QSH 298

Query: 132 TKRVGIIAWHPTAR 145
              +  +AW+P  +
Sbjct: 299 EDSLTSVAWNPDGK 312



 Score = 31.6 bits (70), Expect = 1.7
 Identities = 26/85 (30%), Positives = 35/85 (41%), Gaps = 7/85 (8%)

Query: 26  YEDIRVSRVTWDSTFCAVNPKFLAVIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPV 85
           Y+ +     T  S F   N  F+A     SG     V    K   +  A  T  GHT  V
Sbjct: 417 YQGVTQGFYTIHSCFGGHNEDFIA-----SGSEDHKVYIWHKRSELPIAELT--GHTRTV 469

Query: 86  LDIDWCPHNDEVIASGSEDCTVMVW 110
             + W P    ++AS S+D TV +W
Sbjct: 470 NCVSWNPQIPSMMASASDDGTVRIW 494


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 33/133 (24%), Positives = 60/133 (45%), Gaps = 7/133 (5%)

Query: 81  HTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIAW 140
           H   +L  DWC +N+ ++ +G+ DC++  W +        + +PV  L GHT  +  + +
Sbjct: 197 HQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRN------VRQPVFELLGHTYAIRRVKF 250

Query: 141 HPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSACK-DKS 199
            P   +VL S   D  V  WN    + L      H +    + ++       + C  D++
Sbjct: 251 SPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDET 310

Query: 200 VRIIDPRRGTLVA 212
           ++I DP   T+ A
Sbjct: 311 IKIYDPACLTIPA 323



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 38/153 (24%), Positives = 71/153 (46%), Gaps = 14/153 (9%)

Query: 55  SGGGAFLVLPLSKTG-RIDKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIP 113
           +G G  L+L   + G R+ +++    G    + D+ W  +N+ V+ + S D ++ +W   
Sbjct: 43  AGCGTLLILDPDEAGLRLFRSFDWNDG----LFDVTWSENNEHVLITCSGDGSLQLWD-- 96

Query: 114 ENGLTSPLTEPVVVLEGHTKRVGIIAWHPT-ARNVLLSAGCDNVVLIWNVGTAEELYRLD 172
               T+    P+ V + H + V  + W  T    +++S   D  V +W+    + L    
Sbjct: 97  ----TAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWDQTVKLWDPTVGKSLCTFR 152

Query: 173 SLHPDLIYNVSWN-HNGSLFCSACKDKSVRIID 204
             H  +IY+  W+ H    F SA  D+++RI D
Sbjct: 153 G-HESIIYSTIWSPHIPGCFASASGDQTLRIWD 184



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 40/159 (25%), Positives = 64/159 (40%), Gaps = 13/159 (8%)

Query: 50  VIVEASGGGAFLVLPLSKTGRIDKAYPTVCGHTGPVLDIDWCP-HNDEVIASGSEDCTVM 108
           V++  SG G+  +   +K     + Y     H   V  +DW     ++++ SGS D TV 
Sbjct: 82  VLITCSGDGSLQLWDTAKAAGPLQVYKE---HAQEVYSVDWSQTRGEQLVVSGSWDQTVK 138

Query: 109 VWQIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEEL 168
           +W  P  G      + +    GH   +    W P       SA  D  + IW+V  A   
Sbjct: 139 LWD-PTVG------KSLCTFRGHESIIYSTIWSPHIPGCFASASGDQTLRIWDVKAAGVR 191

Query: 169 YRLDSLHPDLIYNVSW-NHNGSLFCSACKDKSVRIIDPR 206
             + + H   I +  W  +N +L  +   D S+R  D R
Sbjct: 192 IVIPA-HQAEILSCDWCKYNENLLVTGAVDCSLRGWDLR 229



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 17/73 (23%), Positives = 33/73 (45%), Gaps = 2/73 (2%)

Query: 138 IAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWN--HNGSLFCSAC 195
           + W     +VL++   D  + +W+   A    ++   H   +Y+V W+      L  S  
Sbjct: 73  VTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGS 132

Query: 196 KDKSVRIIDPRRG 208
            D++V++ DP  G
Sbjct: 133 WDQTVKLWDPTVG 145


>gi|5902034 periodic tryptophan protein 1 [Homo sapiens]
          Length = 501

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 53/221 (23%), Positives = 92/221 (41%), Gaps = 15/221 (6%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHTKRVGIIA 139
           GHT  VLD+ W      V+AS S D TV++W +        L +P   L  HT +V  + 
Sbjct: 254 GHTDAVLDLSWNKLIRNVLASASADNTVILWDM-------SLGKPAASLAVHTDKVQTLQ 306

Query: 140 WHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNH-NGSLFCSACKDK 198
           +HP     L+S   D  V +++  + +E +R+       I  V+WNH +   F ++  D 
Sbjct: 307 FHPFEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQ-IERVTWNHFSPCHFLASTDDG 365

Query: 199 SVRIIDPRRGTLVAEREKAHEGARPMRAIFLADGKVFTTGFSRMSERQLALWDPENLEEP 258
            V  +D R    +      ++    +       G + T      +++ + +WD    + P
Sbjct: 366 FVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTAS----ADKYVKIWDILG-DRP 420

Query: 259 MALQELDSSNGALL-PFYDPDTSVVYVCGKGDSSIRYFEIT 298
             +   D   G L      PD   +Y  G     +R ++I+
Sbjct: 421 SLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQKEGLRVWDIS 461



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 26/79 (32%), Positives = 41/79 (51%), Gaps = 2/79 (2%)

Query: 129 EGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWN-HN 187
           EGHT  V  ++W+   RNVL SA  DN V++W++   +    L ++H D +  + ++   
Sbjct: 253 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASL-AVHTDKVQTLQFHPFE 311

Query: 188 GSLFCSACKDKSVRIIDPR 206
                S   DKSV + D R
Sbjct: 312 AQTLISGSYDKSVALYDCR 330


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 17/148 (11%)

Query: 72  DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGH 131
           D    T  GHT  V  I W P +  ++AS S+D T+ +W + ++     L       + H
Sbjct: 349 DHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDL-------QAH 400

Query: 132 TKRVGIIAWHPT--------ARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVS 183
           +K +  I W PT        +  +L SA  D+ V +W+V      + L   H + +Y+V+
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK-HQEPVYSVA 459

Query: 184 WNHNGSLFCSACKDKSVRIIDPRRGTLV 211
           ++ +G    S   DK V I + + G+LV
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLV 487



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/138 (29%), Positives = 55/138 (39%), Gaps = 15/138 (10%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN---GLTSPLTEPVVVLEGH----T 132
           GH   V    W P +D ++ASGS D T  +W + EN   G T  +    +   GH     
Sbjct: 177 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIW--NVGTAEELYRLDSLHPDLIYNVSWNHNGSL 190
           K V  + W+     +L     D    IW  N   A  L      H   I+ + WN  G+ 
Sbjct: 236 KDVTSLDWNSDG-TLLAMGSYDGFARIWTENGNLASTL----GQHKGPIFALKWNKKGNY 290

Query: 191 FCSACKDKSVRIIDPRRG 208
             SA  DK+  I D   G
Sbjct: 291 VLSAGVDKTTIIWDAHTG 308



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 18/132 (13%)

Query: 81  HTGPVLDIDWCP--------HNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHT 132
           H+  +  I W P        ++  ++AS S D TV +W + +   T  L +       H 
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK-------HQ 452

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFC 192
           + V  +A+ P  +  L S   D  V IWN  +   ++         I+ V WN  G    
Sbjct: 453 EPVYSVAFSPDGK-YLASGSFDKYVHIWNTQSGSLVHSYQGTGG--IFEVCWNARGDKVG 509

Query: 193 SACKDKSVRIID 204
           ++  D SV ++D
Sbjct: 510 ASASDGSVCVLD 521



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 18/128 (14%)

Query: 80  GHTGP----VLDIDWCPHNDEVIASGSEDCTVMVWQIPENG-LTSPLTEPVVVLEGHTKR 134
           GH  P    V  +DW   +  ++A GS D    +W   ENG L S L +       H   
Sbjct: 229 GHDVPSNKDVTSLDW-NSDGTLLAMGSYDGFARIWT--ENGNLASTLGQ-------HKGP 278

Query: 135 VGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSA 194
           +  + W+    N +LSAG D   +IW+  T E   +    H     +V W +N   F S 
Sbjct: 279 IFALKWNKKG-NYVLSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQNN-MTFASC 335

Query: 195 CKDKSVRI 202
             D  + +
Sbjct: 336 STDMCIHV 343



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 29/105 (27%), Positives = 44/105 (41%), Gaps = 22/105 (20%)

Query: 111 QIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GT 164
           +IP N  T        VL GH   V I AW+P + ++L S   D+   IWN+      G+
Sbjct: 166 EIPPNKAT--------VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGS 216

Query: 165 AEELYR-------LDSLHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
            + + R        D      + ++ WN +G+L      D   RI
Sbjct: 217 TQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARI 261


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 17/148 (11%)

Query: 72  DKAYPTVCGHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGH 131
           D    T  GHT  V  I W P +  ++AS S+D T+ +W + ++     L       + H
Sbjct: 349 DHPVKTFQGHTNEVNAIKWDP-SGMLLASCSDDMTLKIWSMKQDACVHDL-------QAH 400

Query: 132 TKRVGIIAWHPT--------ARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVS 183
           +K +  I W PT        +  +L SA  D+ V +W+V      + L   H + +Y+V+
Sbjct: 401 SKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK-HQEPVYSVA 459

Query: 184 WNHNGSLFCSACKDKSVRIIDPRRGTLV 211
           ++ +G    S   DK V I + + G+LV
Sbjct: 460 FSPDGKYLASGSFDKYVHIWNTQSGSLV 487



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 41/138 (29%), Positives = 55/138 (39%), Gaps = 15/138 (10%)

Query: 80  GHTGPVLDIDWCPHNDEVIASGSEDCTVMVWQIPEN---GLTSPLTEPVVVLEGH----T 132
           GH   V    W P +D ++ASGS D T  +W + EN   G T  +    +   GH     
Sbjct: 177 GHESEVFICAWNPVSD-LLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSN 235

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIW--NVGTAEELYRLDSLHPDLIYNVSWNHNGSL 190
           K V  + W+     +L     D    IW  N   A  L      H   I+ + WN  G+ 
Sbjct: 236 KDVTSLDWNSDG-TLLAMGSYDGFARIWTENGNLASTL----GQHKGPIFALKWNKKGNY 290

Query: 191 FCSACKDKSVRIIDPRRG 208
             SA  DK+  I D   G
Sbjct: 291 VLSAGVDKTTIIWDAHTG 308



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 18/132 (13%)

Query: 81  HTGPVLDIDWCP--------HNDEVIASGSEDCTVMVWQIPENGLTSPLTEPVVVLEGHT 132
           H+  +  I W P        ++  ++AS S D TV +W + +   T  L +       H 
Sbjct: 400 HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMK-------HQ 452

Query: 133 KRVGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFC 192
           + V  +A+ P  +  L S   D  V IWN  +   ++         I+ V WN  G    
Sbjct: 453 EPVYSVAFSPDGK-YLASGSFDKYVHIWNTQSGSLVHSYQGTGG--IFEVCWNARGDKVG 509

Query: 193 SACKDKSVRIID 204
           ++  D SV ++D
Sbjct: 510 ASASDGSVCVLD 521



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 36/128 (28%), Positives = 53/128 (41%), Gaps = 18/128 (14%)

Query: 80  GHTGP----VLDIDWCPHNDEVIASGSEDCTVMVWQIPENG-LTSPLTEPVVVLEGHTKR 134
           GH  P    V  +DW   +  ++A GS D    +W   ENG L S L +       H   
Sbjct: 229 GHDVPSNKDVTSLDW-NSDGTLLAMGSYDGFARIWT--ENGNLASTLGQ-------HKGP 278

Query: 135 VGIIAWHPTARNVLLSAGCDNVVLIWNVGTAEELYRLDSLHPDLIYNVSWNHNGSLFCSA 194
           +  + W+    N +LSAG D   +IW+  T E   +    H     +V W +N   F S 
Sbjct: 279 IFALKWNKKG-NYVLSAGVDKTTIIWDAHTGEAKQQF-PFHSAPALDVDWQNN-MTFASC 335

Query: 195 CKDKSVRI 202
             D  + +
Sbjct: 336 STDMCIHV 343



 Score = 33.5 bits (75), Expect = 0.45
 Identities = 29/105 (27%), Positives = 44/105 (41%), Gaps = 22/105 (20%)

Query: 111 QIPENGLTSPLTEPVVVLEGHTKRVGIIAWHPTARNVLLSAGCDNVVLIWNV------GT 164
           +IP N  T        VL GH   V I AW+P + ++L S   D+   IWN+      G+
Sbjct: 166 EIPPNKAT--------VLRGHESEVFICAWNPVS-DLLASGSGDSTARIWNLNENSNGGS 216

Query: 165 AEELYR-------LDSLHPDLIYNVSWNHNGSLFCSACKDKSVRI 202
            + + R        D      + ++ WN +G+L      D   RI
Sbjct: 217 TQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARI 261


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,106,069
Number of Sequences: 37866
Number of extensions: 938358
Number of successful extensions: 4161
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 179
Number of HSP's that attempted gapping in prelim test: 3410
Number of HSP's gapped (non-prelim): 670
length of query: 489
length of database: 18,247,518
effective HSP length: 106
effective length of query: 383
effective length of database: 14,233,722
effective search space: 5451515526
effective search space used: 5451515526
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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