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Search of human proteins with 14149716
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
(782 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ... 1555 0.0
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 360 4e-99
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 360 4e-99
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 332 8e-91
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 332 8e-91
gi|219842214 protein phosphatase 1, regulatory (inhibitor) subun... 295 8e-80
gi|14249672 protein phosphatase 1, regulatory (inhibitor) subuni... 202 7e-52
gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 1... 188 2e-47
gi|14195597 protein phosphatase 1, regulatory (inhibitor) subuni... 112 1e-24
gi|62177127 myosin heavy chain Myr 8 [Homo sapiens] 112 1e-24
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 107 6e-23
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 107 6e-23
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 103 5e-22
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 102 1e-21
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 101 2e-21
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 100 4e-21
gi|56090539 dysferlin-interacting protein 1 [Homo sapiens] 100 7e-21
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 97 6e-20
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 97 8e-20
gi|18079216 CASK interacting protein 1 [Homo sapiens] 96 1e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 96 1e-19
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 96 1e-19
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 94 4e-19
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 94 4e-19
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 94 4e-19
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 94 4e-19
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 94 4e-19
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 88 3e-17
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 88 3e-17
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 88 3e-17
>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
sapiens]
Length = 782
Score = 1555 bits (4027), Expect = 0.0
Identities = 782/782 (100%), Positives = 782/782 (100%)
Query: 1 MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACA 60
MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACA
Sbjct: 1 MSGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRARTVRFERAAEFLAACA 60
Query: 61 GGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL 120
GGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL
Sbjct: 61 GGDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL 120
Query: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME
Sbjct: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
Query: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240
GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI
Sbjct: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240
Query: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA
Sbjct: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
Query: 301 DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLS 360
DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLS
Sbjct: 301 DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLS 360
Query: 361 KERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRF 420
KERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRF
Sbjct: 361 KERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRF 420
Query: 421 GLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLP 480
GLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLP
Sbjct: 421 GLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLP 480
Query: 481 EPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDE 540
EPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDE
Sbjct: 481 EPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDE 540
Query: 541 ESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVE 600
ESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVE
Sbjct: 541 ESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVE 600
Query: 601 NSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR 660
NSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR
Sbjct: 601 NSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR 660
Query: 661 RQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQ 720
RQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQ
Sbjct: 661 RQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQ 720
Query: 721 RQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKL 780
RQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKL
Sbjct: 721 RQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKL 780
Query: 781 SK 782
SK
Sbjct: 781 SK 782
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 360 bits (923), Expect = 4e-99
Identities = 265/824 (32%), Positives = 395/824 (47%), Gaps = 109/824 (13%)
Query: 16 AAARERRREQLRQW-GARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEA-RLMLRA 73
A A+++R EQL++W G+ EP +R+ V+F+ A FLAAC+ GD DE +L+ R
Sbjct: 4 ADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRG 63
Query: 74 ADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNE 133
AD ++ N DG++ALHQACID+N+++V+FLVE GA +NQ DNE
Sbjct: 64 AD------------------INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
Query: 134 GWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVD 193
GW PLH AASCGYLDIA +L+ GA++ AVNS+GD PLD+AE +AME LL+ E+ R+GVD
Sbjct: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165
Query: 194 VEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDP 253
+EAA++ EE ++L D R WLN G + + RH ++G +ALHVAAAKGY EV++LL+QAGYD
Sbjct: 166 IEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDV 225
Query: 254 ELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELAR 313
++D DGWTPLHAAAHWG E+ACR+L ++ M+ + GQ D+ADE++L LEEL +
Sbjct: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQK 285
Query: 314 KQEDLRNQKE-------ASQSRGQEPQAPSSSKHRRS-------SVCRLSS--REKISLQ 357
KQ L ++K S + Q+ + K++ + + R+ S +EK+ +
Sbjct: 286 KQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEE 345
Query: 358 DLSKERRPGGAGGPPIQDEDEGEEGPTEPPP-------------------AEPRTLNGVS 398
+ K+ + +D+ E E + P P +G +
Sbjct: 346 EEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQA 405
Query: 399 SPPHP-----------SPKSPVQLEEAPFSRRFGLLKTGSSGAL--------GPPERRTA 439
+P P SPK + +E+P + R GL KTGS GAL G E+ TA
Sbjct: 406 TPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTA 465
Query: 440 EGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSE-VTKPPPCLENS 498
A R +SS + +K RLA + PT +L S + E + L S
Sbjct: 466 GVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTS 525
Query: 499 SPPSRIP-EPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557
S +R E + +V ST + S RR+ + + S S Q
Sbjct: 526 SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKS 585
Query: 558 RSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGP 617
+ T T + +AG + + D + + + DS P
Sbjct: 586 LLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK-------DSVPTAVTIP----V 634
Query: 618 GPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESE 677
P A SST E R+R + L P + ESE
Sbjct: 635 APTVV----------NAAASTTTLTTTTAGTVSSTTE-----VRERRRSYLTPVRDEESE 679
Query: 678 EPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERF 737
R + R++ R + +T T L+ A+ + R+T+ +E+ E E E
Sbjct: 680 SQ----RKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEK---EKEEK 732
Query: 738 ERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLS 781
E++ E++ + E E + + R DE R +S S
Sbjct: 733 EKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSS 776
Score = 132 bits (333), Expect = 9e-31
Identities = 100/278 (35%), Positives = 146/278 (52%), Gaps = 29/278 (10%)
Query: 515 VPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKA 574
V T+S+ P+ S S + SQ + L+ + ++G+T + +E EK
Sbjct: 772 VSTSSSTTPSSSLSTMSSSLY------ASSQLNRPNSLVGITSAYSRGITKENEREGEKR 825
Query: 575 AG-KAPESEKPAQSLDPSRRPRVP----GV----ENSDSPAQRAEAPDGQGPGPQAAREH 625
K E + +S+ RRPR GV ++SD Q ++ +G + +
Sbjct: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
Query: 626 RKVGKEWRGPAEGEEAEPA-DRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFR 684
E + G+ + RS S LE + P ++ F+
Sbjct: 886 SISRYETSSTSAGDRYDSLLGRSGSYSYLE------------ERKPYSSRLEKDDSTDFK 933
Query: 685 TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALER 744
LY ++ ENE+L+ L +T + L LK++LE+ATQRQERFA+R +LLE+E+ ERRALER
Sbjct: 934 KLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADR-SLLEMEKRERRALER 992
Query: 745 KAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782
+ +E+EEELK L DL+ADNQRLKDEN ALIRVISKLSK
Sbjct: 993 RISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
Score = 93.6 bits (231), Expect = 6e-19
Identities = 94/318 (29%), Positives = 125/318 (39%), Gaps = 40/318 (12%)
Query: 433 PPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPP 492
P T AGLQ+S SS T + T + E S E P
Sbjct: 568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 627
Query: 493 PCLENSSPPSRIPEPESPAKPNVPTAST-APPADSRDRRRSYQMPVRDEESESQRKARSR 551
+ P+ + S TA T + + R+RRRSY PVRDEESESQRKARSR
Sbjct: 628 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 687
Query: 552 LMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEA 611
RQSRRSTQGVTLTDL+EAEK G+ SR R EN + + E
Sbjct: 688 QARQSRRSTQGVTLTDLQEAEKTIGR-------------SRSTRTREQENEEKEKEEKEK 734
Query: 612 PDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPE 671
D +E ++ KE E E + R+ + + +QR P
Sbjct: 735 QD---------KEKQEEKKESETSREDEYKQKYSRTYD------------ETYQR-YRPV 772
Query: 672 PEPESEEPDGGFRT----LYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE 727
S P T LYA + +T R + E E + +E+ E
Sbjct: 773 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 832
Query: 728 RPALLELERFERRALERK 745
+ + R RR E++
Sbjct: 833 DKSQPKSIRERRRPREKR 850
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 360 bits (923), Expect = 4e-99
Identities = 265/824 (32%), Positives = 395/824 (47%), Gaps = 109/824 (13%)
Query: 16 AAARERRREQLRQW-GARAGAEPGPGERRARTVRFERAAEFLAACAGGDLDEA-RLMLRA 73
A A+++R EQL++W G+ EP +R+ V+F+ A FLAAC+ GD DE +L+ R
Sbjct: 4 ADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRG 63
Query: 74 ADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNE 133
AD ++ N DG++ALHQACID+N+++V+FLVE GA +NQ DNE
Sbjct: 64 AD------------------INYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNE 105
Query: 134 GWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVD 193
GW PLH AASCGYLDIA +L+ GA++ AVNS+GD PLD+AE +AME LL+ E+ R+GVD
Sbjct: 106 GWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVD 165
Query: 194 VEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDP 253
+EAA++ EE ++L D R WLN G + + RH ++G +ALHVAAAKGY EV++LL+QAGYD
Sbjct: 166 IEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDV 225
Query: 254 ELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELAR 313
++D DGWTPLHAAAHWG E+ACR+L ++ M+ + GQ D+ADE++L LEEL +
Sbjct: 226 NIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVADEDILGYLEELQK 285
Query: 314 KQEDLRNQKE-------ASQSRGQEPQAPSSSKHRRS-------SVCRLSS--REKISLQ 357
KQ L ++K S + Q+ + K++ + + R+ S +EK+ +
Sbjct: 286 KQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEPEKNASRIESLEQEKVDEE 345
Query: 358 DLSKERRPGGAGGPPIQDEDEGEEGPTEPPP-------------------AEPRTLNGVS 398
+ K+ + +D+ E E + P P +G +
Sbjct: 346 EEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSSTQAAPVAVTTPTVSSGQA 405
Query: 399 SPPHP-----------SPKSPVQLEEAPFSRRFGLLKTGSSGAL--------GPPERRTA 439
+P P SPK + +E+P + R GL KTGS GAL G E+ TA
Sbjct: 406 TPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYGALAEITASKEGQKEKDTA 465
Query: 440 EGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSE-VTKPPPCLENS 498
A R +SS + +K RLA + PT +L S + E + L S
Sbjct: 466 GVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLASTSDIEEKENRDSSSLRTS 525
Query: 499 SPPSRIP-EPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557
S +R E + +V ST + S RR+ + + S S Q
Sbjct: 526 SSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSVPSTTSTPTVTSAAGLQKS 585
Query: 558 RSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGP 617
+ T T + +AG + + D + + + DS P
Sbjct: 586 LLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK-------DSVPTAVTIP----V 634
Query: 618 GPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESE 677
P A SST E R+R + L P + ESE
Sbjct: 635 APTVV----------NAAASTTTLTTTTAGTVSSTTE-----VRERRRSYLTPVRDEESE 679
Query: 678 EPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERF 737
R + R++ R + +T T L+ A+ + R+T+ +E+ E E E
Sbjct: 680 SQ----RKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEK---EKEEK 732
Query: 738 ERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISKLS 781
E++ E++ + E E + + R DE R +S S
Sbjct: 733 EKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVSTSS 776
Score = 132 bits (333), Expect = 9e-31
Identities = 100/278 (35%), Positives = 146/278 (52%), Gaps = 29/278 (10%)
Query: 515 VPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKA 574
V T+S+ P+ S S + SQ + L+ + ++G+T + +E EK
Sbjct: 772 VSTSSSTTPSSSLSTMSSSLY------ASSQLNRPNSLVGITSAYSRGITKENEREGEKR 825
Query: 575 AG-KAPESEKPAQSLDPSRRPRVP----GV----ENSDSPAQRAEAPDGQGPGPQAAREH 625
K E + +S+ RRPR GV ++SD Q ++ +G + +
Sbjct: 826 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 885
Query: 626 RKVGKEWRGPAEGEEAEPA-DRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFR 684
E + G+ + RS S LE + P ++ F+
Sbjct: 886 SISRYETSSTSAGDRYDSLLGRSGSYSYLE------------ERKPYSSRLEKDDSTDFK 933
Query: 685 TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALER 744
LY ++ ENE+L+ L +T + L LK++LE+ATQRQERFA+R +LLE+E+ ERRALER
Sbjct: 934 KLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADR-SLLEMEKRERRALER 992
Query: 745 KAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782
+ +E+EEELK L DL+ADNQRLKDEN ALIRVISKLSK
Sbjct: 993 RISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 1030
Score = 93.6 bits (231), Expect = 6e-19
Identities = 94/318 (29%), Positives = 125/318 (39%), Gaps = 40/318 (12%)
Query: 433 PPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPP 492
P T AGLQ+S SS T + T + E S E P
Sbjct: 568 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 627
Query: 493 PCLENSSPPSRIPEPESPAKPNVPTAST-APPADSRDRRRSYQMPVRDEESESQRKARSR 551
+ P+ + S TA T + + R+RRRSY PVRDEESESQRKARSR
Sbjct: 628 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 687
Query: 552 LMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEA 611
RQSRRSTQGVTLTDL+EAEK G+ SR R EN + + E
Sbjct: 688 QARQSRRSTQGVTLTDLQEAEKTIGR-------------SRSTRTREQENEEKEKEEKEK 734
Query: 612 PDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPE 671
D +E ++ KE E E + R+ + + +QR P
Sbjct: 735 QD---------KEKQEEKKESETSREDEYKQKYSRTYD------------ETYQR-YRPV 772
Query: 672 PEPESEEPDGGFRT----LYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE 727
S P T LYA + +T R + E E + +E+ E
Sbjct: 773 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 832
Query: 728 RPALLELERFERRALERK 745
+ + R RR E++
Sbjct: 833 DKSQPKSIRERRRPREKR 850
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 332 bits (851), Expect = 8e-91
Identities = 246/732 (33%), Positives = 350/732 (47%), Gaps = 95/732 (12%)
Query: 12 GAAAAAARERRREQLRQW---------GARAGAEPGPGERRART-VRFERAAEFLAACAG 61
G A +AR RR EQLR+W R GA P RR VRFE A FLAAC+
Sbjct: 9 GKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68
Query: 62 GDLDEAR-LMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL 120
GD DE R L+ R AD +++ N DG++ALHQACIDENL++V+FL
Sbjct: 69 GDTDEVRKLLARGAD------------------INTVNVDGLTALHQACIDENLDMVKFL 110
Query: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
VE A VNQ DNEGWTPLH AASCGYL+IA Y ++HGA++ VNS+G++P DLAE AM+
Sbjct: 111 VENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMK 170
Query: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240
LL ++ ++G+D+E +++ EE+ +L D R WLN G + + R R+GA+ALHVAAAKGY
Sbjct: 171 DLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
Query: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
EV+RLL+QAGY+ ++D DGWTPLHAAAHWGV++AC +LAE MD GQ P D+A
Sbjct: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
Query: 301 DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHR----RSSVCRLSSREKISL 356
DE ++ LE L +KQ LR++KE +R + ++ +SK + ++ L E
Sbjct: 291 DEGLVEHLELLQKKQNVLRSEKE---TRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKS 347
Query: 357 QDLSKERRPGGAGGPPIQD-EDEGEEGPTE--------------------------PPPA 389
Q++ +E + + ++ EDE E TE P PA
Sbjct: 348 QEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPA 407
Query: 390 E----PRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGP-PERRTAEGAPG 444
+ + SS P+ P +E+P S R GL KTGS L R G
Sbjct: 408 QNTFSASSARRFSSGLFNKPEEP--KDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRG 465
Query: 445 AGLQRSASSSWLEGTSTQAKELR--LARITPTPSPKLPEPSVLSEVTKPPPC---LENSS 499
+ + RS+SS + + R + I+ KL S + E + + S
Sbjct: 466 SSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGS 525
Query: 500 PPSRIPEPESPAK--PNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557
++ E+ P ST + Q E++ + + L +
Sbjct: 526 YTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITN 585
Query: 558 R----STQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPD 613
R + GVT T + EK L P R + + S R
Sbjct: 586 RPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRS 645
Query: 614 GQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR------------- 660
QG +E + R + +E +P ++ ++ LEG P
Sbjct: 646 TQGVTLTDLQEAERTFSRSRAERQAQE-QPREKPTDTEGLEGSPEKHEPSAVPATEAGEG 704
Query: 661 RQRWQRDLNPEP 672
+Q W R L+ EP
Sbjct: 705 QQPWGRSLDEEP 716
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 332 bits (851), Expect = 8e-91
Identities = 246/732 (33%), Positives = 350/732 (47%), Gaps = 95/732 (12%)
Query: 12 GAAAAAARERRREQLRQW---------GARAGAEPGPGERRART-VRFERAAEFLAACAG 61
G A +AR RR EQLR+W R GA P RR VRFE A FLAAC+
Sbjct: 9 GKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSPRVRFEDGAVFLAACSS 68
Query: 62 GDLDEAR-LMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFL 120
GD DE R L+ R AD +++ N DG++ALHQACIDENL++V+FL
Sbjct: 69 GDTDEVRKLLARGAD------------------INTVNVDGLTALHQACIDENLDMVKFL 110
Query: 121 VEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
VE A VNQ DNEGWTPLH AASCGYL+IA Y ++HGA++ VNS+G++P DLAE AM+
Sbjct: 111 VENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMK 170
Query: 181 GLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYI 240
LL ++ ++G+D+E +++ EE+ +L D R WLN G + + R R+GA+ALHVAAAKGY
Sbjct: 171 DLLLEQVKKQGIDLEQSRKEEEQQMLQDARQWLNSGKIEDVRQARSGATALHVAAAKGYS 230
Query: 241 EVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
EV+RLL+QAGY+ ++D DGWTPLHAAAHWGV++AC +LAE MD GQ P D+A
Sbjct: 231 EVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVA 290
Query: 301 DEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHR----RSSVCRLSSREKISL 356
DE ++ LE L +KQ LR++KE +R + ++ +SK + ++ L E
Sbjct: 291 DEGLVEHLELLQKKQNVLRSEKE---TRNKLIESDLNSKIQSGFFKNKEKMLYEEETPKS 347
Query: 357 QDLSKERRPGGAGGPPIQD-EDEGEEGPTE--------------------------PPPA 389
Q++ +E + + ++ EDE E TE P PA
Sbjct: 348 QEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAFVNHSNSESKSSITEQIPAPA 407
Query: 390 E----PRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGP-PERRTAEGAPG 444
+ + SS P+ P +E+P S R GL KTGS L R G
Sbjct: 408 QNTFSASSARRFSSGLFNKPEEP--KDESPSSWRLGLRKTGSHNMLSEVANSREPIRDRG 465
Query: 445 AGLQRSASSSWLEGTSTQAKELR--LARITPTPSPKLPEPSVLSEVTKPPPC---LENSS 499
+ + RS+SS + + R + I+ KL S + E + + S
Sbjct: 466 SSIYRSSSSPRISALLDNKDKERENKSYISSLAPRKLNSTSDIEEKENRESAVNLVRSGS 525
Query: 500 PPSRIPEPESPAK--PNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSR 557
++ E+ P ST + Q E++ + + L +
Sbjct: 526 YTRQLWRDEAKGNEIPQTIAPSTYVSTYLKRTPHKSQADTTAEKTADNVSSSTPLCVITN 585
Query: 558 R----STQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPD 613
R + GVT T + EK L P R + + S R
Sbjct: 586 RPLPSTANGVTATPVLSITGTDSSVEAREKRRSYLTPVRDEEAESLRKARSRQARQTRRS 645
Query: 614 GQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSAR------------- 660
QG +E + R + +E +P ++ ++ LEG P
Sbjct: 646 TQGVTLTDLQEAERTFSRSRAERQAQE-QPREKPTDTEGLEGSPEKHEPSAVPATEAGEG 704
Query: 661 RQRWQRDLNPEP 672
+Q W R L+ EP
Sbjct: 705 QQPWGRSLDEEP 716
>gi|219842214 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform b [Homo sapiens]
Length = 943
Score = 295 bits (756), Expect = 8e-80
Identities = 226/722 (31%), Positives = 336/722 (46%), Gaps = 89/722 (12%)
Query: 116 VVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAE 175
+V+FLVE GA +NQ DNEGW PLH AASCGYLDIA +L+ GA++ AVNS+GD PLD+AE
Sbjct: 1 MVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 60
Query: 176 SDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAA 235
+AME LL+ E+ R+GVD+EAA++ EE ++L D R WLN G + + RH ++G +ALHVAA
Sbjct: 61 EEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAA 120
Query: 236 AKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQR 295
AKGY EV++LL+QAGYD ++D DGWTPLHAAAHWG E+ACR+L ++ M+ + GQ
Sbjct: 121 AKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQT 180
Query: 296 PCDLADEEVLSLLEELARKQEDLRNQKE-------ASQSRGQEPQAPSSSKHRRS----- 343
D+ADE++L LEEL +KQ L ++K S + Q+ + K++ +
Sbjct: 181 AFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMDNNQSQKTFKNKETLIIEP 240
Query: 344 --SVCRLSS--REKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPP----------- 388
+ R+ S +EK+ ++ K+ + +D+ E E + P
Sbjct: 241 EKNASRIESLEQEKVDEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPLASVTNANTSS 300
Query: 389 --------AEPRTLNGVSSPPHP-----------SPKSPVQLEEAPFSRRFGLLKTGSSG 429
P +G ++P P SPK + +E+P + R GL KTGS G
Sbjct: 301 TQAAPVAVTTPTVSSGQATPTSPIKKFPTTATKISPKEEERKDESPATWRLGLRKTGSYG 360
Query: 430 AL--------GPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPE 481
AL G E+ TA A R +SS + +K RLA + PT +L
Sbjct: 361 ALAEITASKEGQKEKDTAGVTRSASSPRLSSSLDNKEKEKDSKGTRLAYVAPTIPRRLAS 420
Query: 482 PSVLSE-VTKPPPCLENSSPPSRIP-EPESPAKPNVPTASTAPPADSRDRRRSYQMPVRD 539
S + E + L SS +R E + +V ST + S RR+ +
Sbjct: 421 TSDIEEKENRDSSSLRTSSSYTRRKWEDDLKKNSSVNEGSTYHKSCSFGRRQDDLISSSV 480
Query: 540 EESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGV 599
+ S S Q + T T + +AG + + D + + +
Sbjct: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEK---- 536
Query: 600 ENSDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSA 659
DS P P A SST E
Sbjct: 537 ---DSVPTAVTIP----VAPTVV----------NAAASTTTLTTTTAGTVSSTTE----- 574
Query: 660 RRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERAT 719
R+R + L P + ESE R + R++ R + +T T L+ A+ + R+T
Sbjct: 575 VRERRRSYLTPVRDEESESQ----RKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRST 630
Query: 720 QRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVISK 779
+ +E+ E E E E++ E++ + E E + + R DE R +S
Sbjct: 631 RTREQENEEK---EKEEKEKQDKEKQEEKKESETSREDEYKQKYSRTYDETYQRYRPVST 687
Query: 780 LS 781
S
Sbjct: 688 SS 689
Score = 132 bits (333), Expect = 9e-31
Identities = 100/278 (35%), Positives = 146/278 (52%), Gaps = 29/278 (10%)
Query: 515 VPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKA 574
V T+S+ P+ S S + SQ + L+ + ++G+T + +E EK
Sbjct: 685 VSTSSSTTPSSSLSTMSSSLY------ASSQLNRPNSLVGITSAYSRGITKENEREGEKR 738
Query: 575 AG-KAPESEKPAQSLDPSRRPRVP----GV----ENSDSPAQRAEAPDGQGPGPQAAREH 625
K E + +S+ RRPR GV ++SD Q ++ +G + +
Sbjct: 739 EEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQEQQSDTEEGSNKKETQTD 798
Query: 626 RKVGKEWRGPAEGEEAEPA-DRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDGGFR 684
E + G+ + RS S LE + P ++ F+
Sbjct: 799 SISRYETSSTSAGDRYDSLLGRSGSYSYLE------------ERKPYSSRLEKDDSTDFK 846
Query: 685 TLYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAERPALLELERFERRALER 744
LY ++ ENE+L+ L +T + L LK++LE+ATQRQERFA+R +LLE+E+ ERRALER
Sbjct: 847 KLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADR-SLLEMEKRERRALER 905
Query: 745 KAAELEEELKALSDLRADNQRLKDENAALIRVISKLSK 782
+ +E+EEELK L DL+ADNQRLKDEN ALIRVISKLSK
Sbjct: 906 RISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK 943
Score = 93.6 bits (231), Expect = 6e-19
Identities = 94/318 (29%), Positives = 125/318 (39%), Gaps = 40/318 (12%)
Query: 433 PPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPP 492
P T AGLQ+S SS T + T + E S E P
Sbjct: 481 PSTTSTPTVTSAAGLQKSLLSSTSTTTKITTGSSSAGTQSSTSNRLWAEDSTEKEKDSVP 540
Query: 493 PCLENSSPPSRIPEPESPAKPNVPTAST-APPADSRDRRRSYQMPVRDEESESQRKARSR 551
+ P+ + S TA T + + R+RRRSY PVRDEESESQRKARSR
Sbjct: 541 TAVTIPVAPTVVNAAASTTTLTTTTAGTVSSTTEVRERRRSYLTPVRDEESESQRKARSR 600
Query: 552 LMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQRAEA 611
RQSRRSTQGVTLTDL+EAEK G+ SR R EN + + E
Sbjct: 601 QARQSRRSTQGVTLTDLQEAEKTIGR-------------SRSTRTREQENEEKEKEEKEK 647
Query: 612 PDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPE 671
D +E ++ KE E E + R+ + + +QR P
Sbjct: 648 QD---------KEKQEEKKESETSREDEYKQKYSRTYD------------ETYQR-YRPV 685
Query: 672 PEPESEEPDGGFRT----LYAELRRENERLREALTETTLRLAQLKVELERATQRQERFAE 727
S P T LYA + +T R + E E + +E+ E
Sbjct: 686 STSSSTTPSSSLSTMSSSLYASSQLNRPNSLVGITSAYSRGITKENEREGEKREEEKEGE 745
Query: 728 RPALLELERFERRALERK 745
+ + R RR E++
Sbjct: 746 DKSQPKSIRERRRPREKR 763
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/109 (33%), Positives = 59/109 (54%), Gaps = 2/109 (1%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G +ALH A EV++ L++ G VN D +GWTPLH AA G + R L+ + ++
Sbjct: 112 GGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDM 171
Query: 161 AAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDT 209
VN G D+A+ D + G L+ E+ ++ + + KR ++ L+ T
Sbjct: 172 EMVNKVGQTAFDVADEDIL-GYLE-ELQKKQNLLHSEKRDKKSPLIEST 218
>gi|14249672 protein phosphatase 1, regulatory (inhibitor) subunit
16A [Homo sapiens]
Length = 528
Score = 202 bits (515), Expect = 7e-52
Identities = 167/529 (31%), Positives = 241/529 (45%), Gaps = 67/529 (12%)
Query: 18 ARERRREQLRQWGA---RAGAEPGPGERRART---------VRFERAAEFLAACAGGDLD 65
A++RR +Q++ W A + GPGER + V F + L A A DL+
Sbjct: 26 AQKRRAQQVKMWAQAEKEAQGKKGPGERPRKEAASQGLLKQVLFPPSVVLLEAAARNDLE 85
Query: 66 EARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGA 125
E R L G+ + P D N DG++ALHQ CID+ E+V+ L+E GA
Sbjct: 86 EVRQFL-------GSGVSP----------DLANEDGLTALHQCCIDDFREMVQQLLEAGA 128
Query: 126 TVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKA 185
+N D+E WTPLH AA+CG+L + L++ GAN+ AVN+DG++P DL + + L+
Sbjct: 129 NINACDSECWTPLHAAATCGHLHLVELLIASGANLLAVNTDGNMPYDLCDDEQTLDCLET 188
Query: 186 EIARRGV---DVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEV 242
+A RG+ +EAA+ E +L D R L GA A GA+ LHVAAA G+ E
Sbjct: 189 AMADRGITQDSIEAARAVPELRMLDDIRSRLQAGADLHAPLDH-GATLLHVAAANGFSEA 247
Query: 243 MRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDL-AD 301
LLL+ +D DGW PLHAAA+WG LL HG +++ + + P D+ D
Sbjct: 248 AALLLEHRASLSAKDQDGWEPLHAAAYWGQVPLVELLVAHGADLNAKSLMDETPLDVCGD 307
Query: 302 EEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISL----- 356
EEV + L EL K + L + S+ R + SS+ R V R+S ++ L
Sbjct: 308 EEVRAKLLELKHKHDAL--LRAQSRQRSLLRRRTSSAGSRGKVVRRVSLTQRTDLYRKQH 365
Query: 357 -QDLSKERRPGGAGGPPIQDEDEGEEG-PTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEA 414
Q+ ++P P +D D+ + G PPP E V SPV+
Sbjct: 366 AQEAIVWQQPPPTSPEPPEDNDDRQTGAELRPPPPEEDNPEVVRPHNGRVGGSPVR---H 422
Query: 415 PFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITP- 473
+S+R L S L P + T L + L Q +L R P
Sbjct: 423 LYSKR---LDRSVSYQLSPLDSTTPH-----TLVHDKAHHTLADLKRQRAAAKLQRPPPE 474
Query: 474 -TPSPKLPEPSVLSEVTKP-----------PPCLENSSPPSRIPEPESP 510
SP+ EP + + P PP L+ ++P P P
Sbjct: 475 GPESPETAEPGLPGDTVTPQPDCGFRAGGDPPLLKLTAPAVEAPVERRP 523
>gi|28626517 protein phosphatase 1 regulatory inhibitor subunit 16B
[Homo sapiens]
Length = 567
Score = 188 bits (477), Expect = 2e-47
Identities = 130/415 (31%), Positives = 198/415 (47%), Gaps = 43/415 (10%)
Query: 17 AARERRREQLRQWGA----------RAGAEPGPGERRARTVRFERAAEFLAACAGGDLDE 66
AA++RR +QL++W + + G RR + V FE + L A D +E
Sbjct: 25 AAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKK-VSFEASVALLEASLRNDAEE 83
Query: 67 ARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGAT 126
R L+ + +P D N DG++ALHQ CID E+V+ L+ GA
Sbjct: 84 VRYFLK----------NKVSP-------DLCNEDGLTALHQCCIDNFEEIVKLLLSHGAN 126
Query: 127 VNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAE 186
VN DNE WTPLH AA+CG++++ + L+ +GA++ AVNSDG++P DL E + +++
Sbjct: 127 VNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETC 186
Query: 187 IARRGVDVEAAKR---AEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVM 243
+A +G+ E A E+ ++ D C + G + + GA+ LH+A A GY+
Sbjct: 187 MAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQ-GATLLHIAGANGYLRAA 245
Query: 244 RLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
LLL G +++D DGW PLHAAA WG LL HG + + T + P DL +EE
Sbjct: 246 ELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEE 305
Query: 304 VLS-LLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKE 362
LL EL K + + + +S S S+ S+ R + SL D +
Sbjct: 306 EFKVLLLELKHKHDVIMKSQLRHKS--------SLSRRTSSAGSRGKVVRRASLSDRTNL 357
Query: 363 RRPGGAGGPPIQDEDEGEEGPTEPPPAEPR--TLNGVSSPPHPSPKSPVQLEEAP 415
R G + E+ T + R + + P+P + PV L E P
Sbjct: 358 YRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFP 412
>gi|14195597 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform c [Homo sapiens]
Length = 208
Score = 112 bits (281), Expect = 1e-24
Identities = 61/125 (48%), Positives = 88/125 (70%), Gaps = 1/125 (0%)
Query: 659 ARRQRWQRDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELER- 717
ARR+ + L E+ + ++ LY EN++L+ L E L LA +K +LE+
Sbjct: 84 ARREAREARLATLTSRVEEDSNRDYKKLYESALTENQKLKTKLQEAQLELADIKSKLEKV 143
Query: 718 ATQRQERFAERPALLELERFERRALERKAAELEEELKALSDLRADNQRLKDENAALIRVI 777
A Q+QE+ ++R ++LE+E+ ERRALERK +E+EEE+K L++L++DNQRLKDEN ALIRVI
Sbjct: 144 AQQKQEKTSDRSSVLEMEKRERRALERKMSEMEEEMKVLTELKSDNQRLKDENGALIRVI 203
Query: 778 SKLSK 782
SKLSK
Sbjct: 204 SKLSK 208
>gi|62177127 myosin heavy chain Myr 8 [Homo sapiens]
Length = 1858
Score = 112 bits (281), Expect = 1e-24
Identities = 71/240 (29%), Positives = 120/240 (50%), Gaps = 7/240 (2%)
Query: 99 ADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGA 158
+ G S LH +N + L+++G VN D + WTP+H+A +C DI L+ GA
Sbjct: 91 SSGGSLLHLCARYDNAFIAEILIDRGVNVNHQDEDFWTPMHIACACDNPDIVLLLVLAGA 150
Query: 159 NIAAVNSDGDLPLDLA-ESDAMEGLLKAEIARRGVDVEAAKRAEEE---LLLHDTRCWLN 214
N+ + +G++PLD A E +L + GVD+ + ++ + + +L D + +L+
Sbjct: 151 NVLLQDVNGNIPLDYAVEGTESSSILLTYLDENGVDLTSLRQMKLQRPMSMLTDVKHFLS 210
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
G ++ G + LH+A A GY EV+ L+L+ G D + D WTPLH AA +G +
Sbjct: 211 SGGNVNEKNDE-GVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTN 269
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLADEEVLS--LLEELARKQEDLRNQKEASQSRGQEP 332
+LL H + ++ D+A E + LL+ +E ++ AS +EP
Sbjct: 270 LVKLLLMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQEEP 329
Score = 73.9 bits (180), Expect = 5e-13
Identities = 45/122 (36%), Positives = 70/122 (57%), Gaps = 7/122 (5%)
Query: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYL 153
++ N +G++ LH AC EVV ++E G +N D++ WTPLH+AA G ++ + L
Sbjct: 215 VNEKNDEGVTLLHMACASGYKEVVSLILEHGGDLNIVDDQYWTPLHLAAKYGQTNLVKLL 274
Query: 154 LSHGANIAAVNSDGDLPLDLAESDAMEG-LLKAEIA---RRGVDVEAAKRAEE---ELLL 206
L H AN VN + + D+A S+ +E LLKAEIA + + A+ A+E E ++
Sbjct: 275 LMHQANPHLVNCNEEKASDIAASEFIEEMLLKAEIAWEEKMKEPLSASTLAQEEPYEEII 334
Query: 207 HD 208
HD
Sbjct: 335 HD 336
Score = 31.6 bits (70), Expect = 3.0
Identities = 32/107 (29%), Positives = 45/107 (42%), Gaps = 12/107 (11%)
Query: 300 ADEEVLSLLEELARKQEDLR-NQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQD 358
+DE L+ LE +K L N K Q G P +P SK ++ R +S ++L +
Sbjct: 1506 SDESPLTPLE--VKKLPVLETNLKYPVQPEGSSPLSPQYSKSQKGDGDRPAS-PGLALFN 1562
Query: 359 LSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSP 405
S P PP P PPPA R ++ PP P+P
Sbjct: 1563 GSGRASPPSTPPPP--------PPPPGPPPAPYRPCAHLAFPPEPAP 1601
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 107 bits (266), Expect = 6e-23
Identities = 93/330 (28%), Positives = 146/330 (44%), Gaps = 47/330 (14%)
Query: 38 GPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAV---- 93
G +RR R + + A FL A G+LD+ L+ G +++ A+
Sbjct: 18 GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKG-----GIDINTCNQNGLNALHLAA 72
Query: 94 -----------------LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWT 136
+DS G +ALH A + EVV+ LV++GA +N G+T
Sbjct: 73 KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132
Query: 137 PLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDA--------MEGLLKAEIA 188
PL++AA ++D+ +YLL +GAN + DG PL +A +E K ++
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 189 RRGVDVEAAK---RAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRL 245
+ + A K ++ LL +D + M R +G + LH+AA G + V L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVN-RTTESGFTPLHIAAHYGNVNVATL 251
Query: 246 LLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA----D 301
LL G + +G TPLH A+ G + +LL + GG +D+ T G P A
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 302 EEVLSLLEE-----LARKQEDLRNQKEASQ 326
++V+ LL E LAR + L A+Q
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQ 341
Score = 103 bits (256), Expect = 8e-22
Identities = 78/239 (32%), Positives = 118/239 (49%), Gaps = 21/239 (8%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P ARA+ +G + LH AC ++V+ LV+ GA++ G TP+HVA
Sbjct: 385 LDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE 201
A G+L+I LL +GA+ N G+ L +A +++ + R G V+A R E
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC-LLRNGALVDARAR-E 496
Query: 202 EELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYD 252
E+ LH + L A P+A G + LH++A +G ++V +LL+AG
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 253 PELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA---DEEVLSLL 308
L G+TPLH AA +G D +LL + DS G P +A D + ++LL
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614
Score = 90.5 bits (223), Expect = 5e-18
Identities = 68/247 (27%), Positives = 114/247 (46%), Gaps = 27/247 (10%)
Query: 62 GDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLV 121
G LD A+L+L+ RA DS +G++ LH A +N +V L+
Sbjct: 574 GSLDVAKLLLQR-----------------RAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 122 EQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEG 181
E+GA+ + G+TPLH+AA + IA LL++GA V G PL LA +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 182 LLKAEIARRGVDVEAAKR--------AEEELLLHDTRCWLNGGAMPEARHPRTGASALHV 233
++ + +G ++ + + A +E ++ GA +A H + G + L V
Sbjct: 677 MVTL-LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIV 734
Query: 234 AAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAG 293
A G ++++ LL+ G + + +G+TPLH AA G +L +HG ++ T G
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 294 QRPCDLA 300
+A
Sbjct: 795 NTALAIA 801
Score = 85.5 bits (210), Expect = 2e-16
Identities = 68/207 (32%), Positives = 94/207 (45%), Gaps = 29/207 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D TN G +ALH A +EVVR L+ GA V+ E TPLH+A+ G +I + LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRG-VDVEAAKRAEEELLLHDTRCWL 213
H A+ A ++G PL ++ AR G VDV + L
Sbjct: 518 QHMAHPDAATTNGYTPLHIS-------------AREGQVDVASV--------------LL 550
Query: 214 NGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVE 273
GA + + G + LHVAA G ++V +LLLQ + +G TPLH AAH+ +
Sbjct: 551 EAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 274 DACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL E G + G P +A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIA 636
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/209 (30%), Positives = 93/209 (44%), Gaps = 27/209 (12%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D T +GI+ LH A N +V+ L+++G ++ +G TPLH AA G+ +
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 316
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRC 211
LL GA + A +G PL +A +G VE K LL H
Sbjct: 317 LLLERGAPLLARTKNGLSPL--------------HMAAQGDHVECVK----HLLQHKA-- 356
Query: 212 WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWG 271
P +ALHVAA G+ V +LLL +P R +G+TPLH A
Sbjct: 357 -------PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Query: 272 VEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++T +G P +A
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVA 438
Score = 81.6 bits (200), Expect = 2e-15
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 8/219 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A++D+ + + LH A E+V+ L++ A + A G+TPLH++A G +D+A
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLL---HD 208
LL GA + G PL +A + K + RR A K L + +D
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607
Query: 209 TR----CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
+ L GA P A + G + LH+AA K +++ LL G + + G TPL
Sbjct: 608 NQKVALLLLEKGASPHAT-AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Query: 265 HAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
H A+ G D LL + G + T +G LA +E
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Score = 58.5 bits (140), Expect = 2e-08
Identities = 31/75 (41%), Positives = 44/75 (58%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G + L AC N+++V FL++QGA VN G+TPLH AA G+ I LL HGA
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 161 AAVNSDGDLPLDLAE 175
A ++G+ L +A+
Sbjct: 788 NATTANGNTALAIAK 802
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 107 bits (266), Expect = 6e-23
Identities = 93/330 (28%), Positives = 146/330 (44%), Gaps = 47/330 (14%)
Query: 38 GPGERRARTVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPPARAV---- 93
G +RR R + + A FL A G+LD+ L+ G +++ A+
Sbjct: 18 GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKG-----GIDINTCNQNGLNALHLAA 72
Query: 94 -----------------LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWT 136
+DS G +ALH A + EVV+ LV++GA +N G+T
Sbjct: 73 KEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT 132
Query: 137 PLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDA--------MEGLLKAEIA 188
PL++AA ++D+ +YLL +GAN + DG PL +A +E K ++
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 189 RRGVDVEAAK---RAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRL 245
+ + A K ++ LL +D + M R +G + LH+AA G + V L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVN-RTTESGFTPLHIAAHYGNVNVATL 251
Query: 246 LLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA----D 301
LL G + +G TPLH A+ G + +LL + GG +D+ T G P A
Sbjct: 252 LLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGH 311
Query: 302 EEVLSLLEE-----LARKQEDLRNQKEASQ 326
++V+ LL E LAR + L A+Q
Sbjct: 312 DQVVELLLERGAPLLARTKNGLSPLHMAAQ 341
Score = 103 bits (256), Expect = 8e-22
Identities = 78/239 (32%), Positives = 118/239 (49%), Gaps = 21/239 (8%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P ARA+ +G + LH AC ++V+ LV+ GA++ G TP+HVA
Sbjct: 385 LDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 438
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE 201
A G+L+I LL +GA+ N G+ L +A +++ + R G V+A R E
Sbjct: 439 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC-LLRNGALVDARAR-E 496
Query: 202 EELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYD 252
E+ LH + L A P+A G + LH++A +G ++V +LL+AG
Sbjct: 497 EQTPLHIASRLGKTEIVQLLLQHMAHPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 253 PELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA---DEEVLSLL 308
L G+TPLH AA +G D +LL + DS G P +A D + ++LL
Sbjct: 556 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 614
Score = 90.5 bits (223), Expect = 5e-18
Identities = 68/247 (27%), Positives = 114/247 (46%), Gaps = 27/247 (10%)
Query: 62 GDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLV 121
G LD A+L+L+ RA DS +G++ LH A +N +V L+
Sbjct: 574 GSLDVAKLLLQR-----------------RAAADSAGKNGLTPLHVAAHYDNQKVALLLL 616
Query: 122 EQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEG 181
E+GA+ + G+TPLH+AA + IA LL++GA V G PL LA +
Sbjct: 617 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 676
Query: 182 LLKAEIARRGVDVEAAKR--------AEEELLLHDTRCWLNGGAMPEARHPRTGASALHV 233
++ + +G ++ + + A +E ++ GA +A H + G + L V
Sbjct: 677 MVTL-LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIV 734
Query: 234 AAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAG 293
A G ++++ LL+ G + + +G+TPLH AA G +L +HG ++ T G
Sbjct: 735 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 794
Query: 294 QRPCDLA 300
+A
Sbjct: 795 NTALAIA 801
Score = 85.5 bits (210), Expect = 2e-16
Identities = 68/207 (32%), Positives = 94/207 (45%), Gaps = 29/207 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D TN G +ALH A +EVVR L+ GA V+ E TPLH+A+ G +I + LL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRG-VDVEAAKRAEEELLLHDTRCWL 213
H A+ A ++G PL ++ AR G VDV + L
Sbjct: 518 QHMAHPDAATTNGYTPLHIS-------------AREGQVDVASV--------------LL 550
Query: 214 NGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVE 273
GA + + G + LHVAA G ++V +LLLQ + +G TPLH AAH+ +
Sbjct: 551 EAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 609
Query: 274 DACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL E G + G P +A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIA 636
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/209 (30%), Positives = 93/209 (44%), Gaps = 27/209 (12%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D T +GI+ LH A N +V+ L+++G ++ +G TPLH AA G+ +
Sbjct: 257 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 316
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRC 211
LL GA + A +G PL +A +G VE K LL H
Sbjct: 317 LLLERGAPLLARTKNGLSPL--------------HMAAQGDHVECVK----HLLQHKA-- 356
Query: 212 WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWG 271
P +ALHVAA G+ V +LLL +P R +G+TPLH A
Sbjct: 357 -------PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 409
Query: 272 VEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++T +G P +A
Sbjct: 410 RIKVMELLVKYGASIQAITESGLTPIHVA 438
Score = 81.6 bits (200), Expect = 2e-15
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 8/219 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A++D+ + + LH A E+V+ L++ A + A G+TPLH++A G +D+A
Sbjct: 488 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 547
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLL---HD 208
LL GA + G PL +A + K + RR A K L + +D
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607
Query: 209 TR----CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
+ L GA P A + G + LH+AA K +++ LL G + + G TPL
Sbjct: 608 NQKVALLLLEKGASPHAT-AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Query: 265 HAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
H A+ G D LL + G + T +G LA +E
Sbjct: 667 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Score = 58.5 bits (140), Expect = 2e-08
Identities = 31/75 (41%), Positives = 44/75 (58%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G + L AC N+++V FL++QGA VN G+TPLH AA G+ I LL HGA
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 161 AAVNSDGDLPLDLAE 175
A ++G+ L +A+
Sbjct: 788 NATTANGNTALAIAK 802
Score = 32.3 bits (72), Expect = 1.7
Identities = 49/263 (18%), Positives = 100/263 (38%), Gaps = 26/263 (9%)
Query: 349 SSREKISLQDLSKERRPGGAGGPPIQ---DEDEGEEGPTEP-PPAEPRTLNGVSSPPHPS 404
S ++K+ E G PI+ ED ++ P P A P + +P PS
Sbjct: 1765 SIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPS 1824
Query: 405 PKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAK 464
PK+ R L + + PP +++ + + SA + S+ +K
Sbjct: 1825 PKT----------ERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSK 1874
Query: 465 ELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPA 524
+ + ++P+ + P ++ + PP PS + P P+ T P +
Sbjct: 1875 TEKHSPVSPSTKTERHSPVSSTKTERHPPV-----SPSGKTDKRPPVSPSGRTEKHPPVS 1929
Query: 525 DSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKP 584
R +R +PV S S R + + + + ++ + + ++ + EK +P S+
Sbjct: 1930 PGRTEKR---LPV----SPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTE 1982
Query: 585 AQSLDPSRRPRVPGVENSDSPAQ 607
S R + ++ P++
Sbjct: 1983 RIEETMSVRELMKAFQSGQDPSK 2005
Score = 32.0 bits (71), Expect = 2.3
Identities = 27/129 (20%), Positives = 48/129 (37%), Gaps = 10/129 (7%)
Query: 501 PSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQR-----KARSRLMRQ 555
P PEP K P P +D+ ++ Q V DE+ + K + + ++
Sbjct: 1741 PGLAPEPLPTVKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPIRVKGKEDVPKK 1800
Query: 556 SRRSTQGVTLTDLKEAEKAAGK-APESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDG 614
+ LK A G +P++E+ + ++ R P V SP+ + E
Sbjct: 1801 TTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPV----SPSSKTEKHSP 1856
Query: 615 QGPGPQAAR 623
P + R
Sbjct: 1857 VSPSAKTER 1865
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 103 bits (258), Expect = 5e-22
Identities = 79/253 (31%), Positives = 122/253 (48%), Gaps = 21/253 (8%)
Query: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYL 153
+DS G +ALH A + EVV+ LV++GA +N G+TPL++AA ++D+ +YL
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 154 LSHGANIAAVNSDGDLPLDLAESDA--------MEGLLKAEIARRGVDVEAAK---RAEE 202
L +GAN + DG PL +A +E K ++ + + A K ++
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188
Query: 203 ELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWT 262
LL +D + M R +G + LH+AA G + V LLL G + +G T
Sbjct: 189 LLLQNDHNADVQSKMMVN-RTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT 247
Query: 263 PLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA----DEEVLSLLEE-----LAR 313
PLH A+ G + +LL + GG +D+ T G P A ++V+ LL E LAR
Sbjct: 248 PLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR 307
Query: 314 KQEDLRNQKEASQ 326
+ L A+Q
Sbjct: 308 TKNGLSPLHMAAQ 320
Score = 103 bits (256), Expect = 8e-22
Identities = 78/239 (32%), Positives = 118/239 (49%), Gaps = 21/239 (8%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P ARA+ +G + LH AC ++V+ LV+ GA++ G TP+HVA
Sbjct: 364 LDKRANPNARAL------NGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVA 417
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE 201
A G+L+I LL +GA+ N G+ L +A +++ + R G V+A R E
Sbjct: 418 AFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC-LLRNGALVDARAR-E 475
Query: 202 EELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYD 252
E+ LH + L A P+A G + LH++A +G ++V +LL+AG
Sbjct: 476 EQTPLHIASRLGKTEIVQLLLQHMAHPDAA-TTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 253 PELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA---DEEVLSLL 308
L G+TPLH AA +G D +LL + DS G P +A D + ++LL
Sbjct: 535 HSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALL 593
Score = 90.5 bits (223), Expect = 5e-18
Identities = 68/247 (27%), Positives = 114/247 (46%), Gaps = 27/247 (10%)
Query: 62 GDLDEARLMLRAADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLV 121
G LD A+L+L+ RA DS +G++ LH A +N +V L+
Sbjct: 553 GSLDVAKLLLQR-----------------RAAADSAGKNGLTPLHVAAHYDNQKVALLLL 595
Query: 122 EQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEG 181
E+GA+ + G+TPLH+AA + IA LL++GA V G PL LA +
Sbjct: 596 EKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTD 655
Query: 182 LLKAEIARRGVDVEAAKR--------AEEELLLHDTRCWLNGGAMPEARHPRTGASALHV 233
++ + +G ++ + + A +E ++ GA +A H + G + L V
Sbjct: 656 MVTL-LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDA-HTKLGYTPLIV 713
Query: 234 AAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAG 293
A G ++++ LL+ G + + +G+TPLH AA G +L +HG ++ T G
Sbjct: 714 ACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANG 773
Query: 294 QRPCDLA 300
+A
Sbjct: 774 NTALAIA 780
Score = 85.5 bits (210), Expect = 2e-16
Identities = 68/207 (32%), Positives = 94/207 (45%), Gaps = 29/207 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D TN G +ALH A +EVVR L+ GA V+ E TPLH+A+ G +I + LL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRG-VDVEAAKRAEEELLLHDTRCWL 213
H A+ A ++G PL ++ AR G VDV + L
Sbjct: 497 QHMAHPDAATTNGYTPLHIS-------------AREGQVDVASV--------------LL 529
Query: 214 NGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVE 273
GA + + G + LHVAA G ++V +LLLQ + +G TPLH AAH+ +
Sbjct: 530 EAGA-AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQ 588
Query: 274 DACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL E G + G P +A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIA 615
Score = 82.0 bits (201), Expect = 2e-15
Identities = 63/209 (30%), Positives = 93/209 (44%), Gaps = 27/209 (12%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D T +GI+ LH A N +V+ L+++G ++ +G TPLH AA G+ +
Sbjct: 236 AAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVE 295
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRC 211
LL GA + A +G PL +A +G VE K LL H
Sbjct: 296 LLLERGAPLLARTKNGLSPL--------------HMAAQGDHVECVK----HLLQHKA-- 335
Query: 212 WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWG 271
P +ALHVAA G+ V +LLL +P R +G+TPLH A
Sbjct: 336 -------PVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388
Query: 272 VEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++T +G P +A
Sbjct: 389 RIKVMELLVKYGASIQAITESGLTPIHVA 417
Score = 81.6 bits (200), Expect = 2e-15
Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 8/219 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A++D+ + + LH A E+V+ L++ A + A G+TPLH++A G +D+A
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 526
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLL---HD 208
LL GA + G PL +A + K + RR A K L + +D
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586
Query: 209 TR----CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
+ L GA P A + G + LH+AA K +++ LL G + + G TPL
Sbjct: 587 NQKVALLLLEKGASPHAT-AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
Query: 265 HAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
H A+ G D LL + G + T +G LA +E
Sbjct: 646 HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684
Score = 58.5 bits (140), Expect = 2e-08
Identities = 31/75 (41%), Positives = 44/75 (58%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G + L AC N+++V FL++QGA VN G+TPLH AA G+ I LL HGA
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Query: 161 AAVNSDGDLPLDLAE 175
A ++G+ L +A+
Sbjct: 767 NATTANGNTALAIAK 781
Score = 56.6 bits (135), Expect = 9e-08
Identities = 53/248 (21%), Positives = 98/248 (39%), Gaps = 45/248 (18%)
Query: 99 ADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGA 158
+D ++ +A NL+ V ++ G +N + G LH+AA G++ + + LL G+
Sbjct: 8 SDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGS 67
Query: 159 NIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKR--------AEEELLLHDTR 210
++ + G+ L +A ++K + + G ++ A + A +E + +
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKV-LVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
Query: 211 CWLNGGA----------------------------MPEARHPRTGASALHVAAAKGYIEV 242
L GA + + ALH+AA K +
Sbjct: 127 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKS 186
Query: 243 MRLLLQAGYDPELRD--------GDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQ 294
LLLQ ++ +++ G+TPLH AAH+G + LL G +D G
Sbjct: 187 AALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 246
Query: 295 RPCDLADE 302
P +A +
Sbjct: 247 TPLHVASK 254
Score = 40.4 bits (93), Expect = 0.006
Identities = 22/79 (27%), Positives = 43/79 (54%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G +ALH+AA +G++ +++ LL G + G T LH A+ G + ++L + G
Sbjct: 41 QNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGA 100
Query: 285 GMDSLTHAGQRPCDLADEE 303
+++ + G P +A +E
Sbjct: 101 NINAQSQNGFTPLYMAAQE 119
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 102 bits (254), Expect = 1e-21
Identities = 74/221 (33%), Positives = 113/221 (51%), Gaps = 14/221 (6%)
Query: 100 DGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
DG + LH A + + R L++ GA V+ + EGWTPLH+AA + ++AR L+S A+
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQAD 486
Query: 160 IAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKR--------AEEELLLHDTRC 211
++G PL +A L+K + +G +++A +R A E + +
Sbjct: 487 PNLHEAEGKTPLHVAAYFGHVSLVKL-LTSQGAELDAQQRNLRTPLHLAVERGKVRAIQH 545
Query: 212 WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWG 271
L GA+P+A ++G LH AAA+G + ++LL+ G EL GWTPLH AA+ G
Sbjct: 546 LLKSGAVPDALD-QSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
Query: 272 VEDACRLLAEHGGGMDSLTHAGQRPCDLA----DEEVLSLL 308
+ LLAE M +L P LA +E V+S L
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645
Score = 81.3 bits (199), Expect = 3e-15
Identities = 60/201 (29%), Positives = 89/201 (44%), Gaps = 27/201 (13%)
Query: 102 ISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIA 161
++ LH ++E VR L+ V+ G+TPL +AA D+ LL+HGA+
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 162 AVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEA 221
V+ DG PL A + +G R L+ GA +A
Sbjct: 423 RVDEDGWAPLHFAAQNGDDG--------------------------TARLLLDHGACVDA 456
Query: 222 RHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAE 281
+ R G + LH+AA + V RLL+ DP L + +G TPLH AA++G +LL
Sbjct: 457 QE-REGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTS 515
Query: 282 HGGGMDSLTHAGQRPCDLADE 302
G +D+ + P LA E
Sbjct: 516 QGAELDAQQRNLRTPLHLAVE 536
Score = 76.6 bits (187), Expect = 8e-14
Identities = 55/184 (29%), Positives = 90/184 (48%), Gaps = 10/184 (5%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
AV D+ + G LH A + + L+ GA++ ++GWTPLH+AA G+L+I
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIH 610
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKR--------AEEE 203
L AN+ A+ + PL LA E ++ A + + G D AA++ A +
Sbjct: 611 LLAESHANMGALGAVNWTPLHLAARHGEEAVVSA-LLQCGADPNAAEQSGWTPLHLAVQR 669
Query: 204 LLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTP 263
L A AR+ + G + H+AA KG ++++L++AG +++DG TP
Sbjct: 670 STFLSVINLLEHHANVHARN-KVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTP 728
Query: 264 LHAA 267
L A
Sbjct: 729 LQLA 732
Score = 52.0 bits (123), Expect = 2e-06
Identities = 34/107 (31%), Positives = 50/107 (46%), Gaps = 3/107 (2%)
Query: 226 TGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGG 285
+G + L +AA ++ LLL G D D DGW PLH AA G + RLL +HG
Sbjct: 394 SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGAC 453
Query: 286 MDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEP 332
+D+ G P LA + + E +AR + ++ G+ P
Sbjct: 454 VDAQEREGWTPLHLAAQ---NNFENVARLLVSRQADPNLHEAEGKTP 497
Score = 46.6 bits (109), Expect = 9e-05
Identities = 32/95 (33%), Positives = 42/95 (44%)
Query: 90 ARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDI 149
+ A + + A + LH A VV L++ GA N A+ GWTPLH+A
Sbjct: 615 SHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLS 674
Query: 150 ARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLK 184
LL H AN+ A N G P LA +LK
Sbjct: 675 VINLLEHHANVHARNKVGWTPAHLAALKGNTAILK 709
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/89 (29%), Positives = 40/89 (44%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++ G + LH A V L+E A V+ + GWTP H+AA G I + L+
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLL 183
GA + + PL LA +G++
Sbjct: 713 EAGAQLDVQDGVSCTPLQLALRSRKQGIM 741
Score = 30.4 bits (67), Expect = 6.6
Identities = 19/72 (26%), Positives = 33/72 (45%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A + + N G + H A + N +++ LVE GA ++ D TPL +A I
Sbjct: 683 ANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMS 742
Query: 152 YLLSHGANIAAV 163
+L ++A +
Sbjct: 743 FLEGKEPSVATL 754
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 101 bits (252), Expect = 2e-21
Identities = 89/313 (28%), Positives = 139/313 (44%), Gaps = 36/313 (11%)
Query: 2 SGEDGPAAGPGAAAAAARERRREQLRQWGARAGAEPGPGERRART---VRFERAAEFLAA 58
S P + ++ ++ E G + A GPG T E L A
Sbjct: 130 SSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEA 189
Query: 59 CAGGDLDEARLMLRAADPGP----GAELDP---AAPPPARAVLD----------STNADG 101
C GD+ + ++ AA+ G + P AA + V++ + + G
Sbjct: 190 CRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGG 249
Query: 102 ISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIA 161
+ LH AC + EVV L+ QGA N DN +TPLH AA G +D+ LL HGA+
Sbjct: 250 LIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPN 309
Query: 162 AVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH-----DTRCWLNGG 216
N+DG LDLA+ A + +L E + + +EAA+ EE L+ + C + G
Sbjct: 310 IRNTDGKSALDLADPSA-KAVLTGEYKKDEL-LEAARSGNEEKLMALLTPLNVNCHASDG 367
Query: 217 AMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDAC 276
++ LH+AA + +++LLLQ G D +D G PLH A +G +
Sbjct: 368 RK---------STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVT 418
Query: 277 RLLAEHGGGMDSL 289
LL +HG ++++
Sbjct: 419 ELLLKHGACVNAM 431
Score = 94.7 bits (234), Expect = 3e-19
Identities = 78/240 (32%), Positives = 108/240 (45%), Gaps = 37/240 (15%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G+ LH AC + EV LV GA+VN AD +TPLH AA+ G +I + LL HGA+
Sbjct: 717 GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADP 776
Query: 161 AAVNSDGDLPLDLA-ESDA-MEGLLKAEIARRGVDVEAAKR----------AEEELLLHD 208
N DG+ PLDL E D ++ LL+ + A ++AAK+ E + D
Sbjct: 777 TKKNRDGNTPLDLVKEGDTDIQDLLRGDAAL----LDAAKKGCLARVQKLCTPENINCRD 832
Query: 209 TR--------------------CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQ 248
T+ L GA A+ + G LH AA+ G++++ LL++
Sbjct: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-DKGGLIPLHNAASYGHVDIAALLIK 891
Query: 249 AGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLL 308
D +TPLH AA G C LL HG GQ P DLA + + L
Sbjct: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL 951
Score = 85.1 bits (209), Expect = 2e-16
Identities = 62/197 (31%), Positives = 96/197 (48%), Gaps = 9/197 (4%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G+ LH AC + EV L++ GA VN D +TPLH AAS +++ LLSHGA+
Sbjct: 402 GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADP 461
Query: 161 AAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPE 220
VN G +D+A + + L E + ++AA+ A+ + +
Sbjct: 462 TLVNCHGKSAVDMAPTPELRERLTYEFKGHSL-LQAAREADLAKVKKTLAL-----EIIN 515
Query: 221 ARHPRTGASALHVAAAKGY---IEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACR 277
+ P++ +ALH A A + +V LLL+ G + ++ D TPLH AA D
Sbjct: 516 FKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVME 575
Query: 278 LLAEHGGGMDSLTHAGQ 294
+L +HG M++L GQ
Sbjct: 576 VLHKHGAKMNALDTLGQ 592
Score = 75.1 bits (183), Expect = 2e-13
Identities = 69/246 (28%), Positives = 106/246 (43%), Gaps = 37/246 (15%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ N D ++ LH A + +V+ L + GA +N D G T LH AA G+L R
Sbjct: 549 ANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCR 608
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDV-----EAAKRAEEELL- 205
LLS+G++ + ++ G + ++A++ +L R DV EA+K + E +
Sbjct: 609 LLLSYGSDPSIISLQGFTAAQMG-NEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667
Query: 206 ---------------LHDT--------------RCWLNGGAMPEARHPRTGASALHVAAA 236
H T L+ GA A+ + G LH A +
Sbjct: 668 QLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK-DKGGLVPLHNACS 726
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
G+ EV LL++ G + D +TPLH AA G + C+LL +HG G P
Sbjct: 727 YGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTP 786
Query: 297 CDLADE 302
DL E
Sbjct: 787 LDLVKE 792
Score = 65.5 bits (158), Expect = 2e-10
Identities = 74/261 (28%), Positives = 103/261 (39%), Gaps = 69/261 (26%)
Query: 73 AADPGPGAELDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADN 132
AA A L P A P V + A + L +AC + ++ V+ LV+ A VN D
Sbjct: 156 AAGVSSTAPLGPGAAGPGTGVPAVSGA--LRELLEACRNGDVSRVKRLVD-AANVNAKDM 212
Query: 133 EGW--TPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARR 190
G +PLH AA G D+ +LL +
Sbjct: 213 AGRKSSPLHFAAGFGRKDVVEHLL----------------------------------QM 238
Query: 191 GVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAG 250
G +V A +GG +P LH A + G+ EV+ LLL G
Sbjct: 239 GANVHARD---------------DGGLIP-----------LHNACSFGHAEVVSLLLCQG 272
Query: 251 YDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEE 310
DP RD +TPLH AA G D C +L +HG + G+ DLAD ++L
Sbjct: 273 ADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG 332
Query: 311 LARKQEDLRNQKEASQSRGQE 331
+K E L EA++S +E
Sbjct: 333 EYKKDELL----EAARSGNEE 349
Score = 62.4 bits (150), Expect = 2e-09
Identities = 58/225 (25%), Positives = 90/225 (40%), Gaps = 44/225 (19%)
Query: 103 SALHQACID---ENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
+ALH A + +V L+ +GA VN+ + + TPLHVAA + D+ L HGA
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 160 IAAVNSDGDLPLDLAE---------------SD----AMEGLLKAEIARRGVD------- 193
+ A+++ G L A SD +++G A++ V
Sbjct: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
Query: 194 -----------VEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEV 242
+EA+K + E + E RH ++ LH AA + V
Sbjct: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRH----STPLHFAAGYNRVSV 699
Query: 243 MRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMD 287
+ LL G D +D G PLH A +G + LL HG ++
Sbjct: 700 VEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744
Score = 60.1 bits (144), Expect = 8e-09
Identities = 31/92 (33%), Positives = 49/92 (53%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +++ + G+ LH A ++++ L++ VN D +TPLH AA G +
Sbjct: 861 ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCA 920
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLL 183
LL+HGA+ N +G PLDLA +D + LL
Sbjct: 921 LLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
Score = 37.0 bits (84), Expect = 0.071
Identities = 37/154 (24%), Positives = 55/154 (35%), Gaps = 30/154 (19%)
Query: 374 QDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPF-SRRFGLLKTGSSGALG 432
Q + + G + PPP P L+ P +P SP APF S R GL G+
Sbjct: 15 QQQLQPAPGASAPPPPPPPPLSP-GLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRD 73
Query: 433 PPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEVTKPP 492
PP+R S ++GTS + + + P
Sbjct: 74 PPDR-------------PRSPDPVDGTSCCSTTSTICTVAAAPVV--------------- 105
Query: 493 PCLENSSPPSRIPEPESPAKPNVPTASTAPPADS 526
P + SS P P N P++S++P + S
Sbjct: 106 PAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSS 139
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 100 bits (250), Expect = 4e-21
Identities = 66/196 (33%), Positives = 99/196 (50%), Gaps = 27/196 (13%)
Query: 91 RAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIA 150
+++ T+ D +ALH AC + E+V FL++ G VN D+ GW+PLH+AAS G +I
Sbjct: 30 KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
Query: 151 RYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTR 210
+ LL GA + AVN +G PL A S R E ++L
Sbjct: 90 KALLGKGAQVNAVNQNGCTPLHYAAS--------------------KNRHEIAVML---- 125
Query: 211 CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHW 270
L GGA P+A+ A+A+H AAAKG ++++ +LL ++D +G TPLH A
Sbjct: 126 --LEGGANPDAK-DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDE 182
Query: 271 GVEDACRLLAEHGGGM 286
+ +LL G +
Sbjct: 183 ERVEEAKLLVSQGASI 198
Score = 53.9 bits (128), Expect = 6e-07
Identities = 45/189 (23%), Positives = 76/189 (40%), Gaps = 27/189 (14%)
Query: 115 EVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLA 174
E+ ++ + + D + T LH A S G+ +I +LL G + + G PL +A
Sbjct: 21 ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
Query: 175 ESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHPRTGASALHVA 234
S + ++KA + + G V A + G + LH A
Sbjct: 81 ASAGRDEIVKALLGK-GAQVNAVNQ--------------------------NGCTPLHYA 113
Query: 235 AAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQ 294
A+K E+ +LL+ G +P+ +D T +H AA G +L + + G
Sbjct: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGN 173
Query: 295 RPCDLADEE 303
P LA +E
Sbjct: 174 TPLHLACDE 182
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
L+ A P A+ ++T A+H+A NL+++ L+ A+ N D EG TPLH+A
Sbjct: 126 LEGGANPDAKDHYEAT------AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAE 175
++ A+ L+S GA+I N + PL +A+
Sbjct: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
>gi|56090539 dysferlin-interacting protein 1 [Homo sapiens]
Length = 154
Score = 100 bits (248), Expect = 7e-21
Identities = 60/151 (39%), Positives = 80/151 (52%), Gaps = 21/151 (13%)
Query: 35 AEPGPGERRAR-----TVRFERAAEFLAACAGGDLDEARLMLRAADPGPGAELDPAAPPP 89
A P +RR R +VRF FL GDL++ +R
Sbjct: 9 ARYSPRQRRRRMLADRSVRFPNDVLFLDHIRQGDLEQVGRFIRTR--------------- 53
Query: 90 ARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDI 149
+ L + + G++ALH+A + NLE V+ LV+ GA ++Q D GWTPLH+A S GY DI
Sbjct: 54 -KVSLATIHPSGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDI 112
Query: 150 ARYLLSHGANIAAVNSDGDLPLDLAESDAME 180
ARYL+S GA+ A N DGDLP DL + D E
Sbjct: 113 ARYLISLGADRDATNDDGDLPSDLIDPDYKE 143
Score = 63.2 bits (152), Expect = 9e-10
Identities = 35/87 (40%), Positives = 45/87 (51%), Gaps = 1/87 (1%)
Query: 223 HPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEH 282
HP +G +ALH A G +E ++LL++ G D RD GWTPLH A G D R L
Sbjct: 61 HP-SGLAALHEAVLSGNLECVKLLVKYGADIHQRDEAGWTPLHIACSDGYPDIARYLISL 119
Query: 283 GGGMDSLTHAGQRPCDLADEEVLSLLE 309
G D+ G P DL D + L+E
Sbjct: 120 GADRDATNDDGDLPSDLIDPDYKELVE 146
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 97.1 bits (240), Expect = 6e-20
Identities = 129/537 (24%), Positives = 209/537 (38%), Gaps = 81/537 (15%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +DS +++G + L A N+EVVR L+++G N D+ GWTPLH+AA G+ I
Sbjct: 805 AAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICE 864
Query: 152 YLLSHGANIAAVNSDGDLPLDLAES----DAMEGLL--KAEIARRGVD---------VEA 196
L+ GA +++DG +P LA D ++ LL K+ I +RG D +E
Sbjct: 865 ALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEG 924
Query: 197 AKRAEEELLLH--DTRC-----------------------WLNGGAMPEARHPRTGASAL 231
+ E L H D C +L GA EA G +AL
Sbjct: 925 HRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAE-GRTAL 983
Query: 232 HVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTH 291
HV+ +G++E++++L+ D D + + L +AA G +LL EHG +D +
Sbjct: 984 HVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043
Query: 292 AGQRP-CDLADEEVLSLLEELARKQEDL-------RNQKEASQSRGQEPQAPSSSKHRRS 343
G C A E + +++ L D R + G K+ S
Sbjct: 1044 QGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103
Query: 344 SVCRLS-----SREKISLQDLS--------KERRPGGAGGPPIQDEDEG-EEGPTEPPPA 389
S+ S + E+ LQ LS K G GG +Q G GPT
Sbjct: 1104 SLNGCSPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTH---- 1159
Query: 390 EPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQR 449
S P SP S V +++ S L + +S TA+ P
Sbjct: 1160 -------AFSSPSESPDSTVDRQKSSLSNN-SLKSSKNSSLRTTSSTATAQTVPIDSFHN 1211
Query: 450 SASSSWLEGTSTQAKELRLARITPTPSPKL-----PEPSVLSEVTKPPPCLENSSPPSRI 504
+ + ++ S R + ++P+ + + PS E ++ P L+ S+ S+
Sbjct: 1212 LSFTEQIQQHSLPRSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKPSLK-STKASKG 1270
Query: 505 PEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQ 561
+ E+ AK S+ + Y+M D + + +Q +Q
Sbjct: 1271 GKSENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQ 1327
Score = 92.0 bits (227), Expect = 2e-18
Identities = 77/258 (29%), Positives = 110/258 (42%), Gaps = 52/258 (20%)
Query: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYL 153
+D +AD +AL A + ++V L++ GA VN+ADNEG T L AA G+ +I +L
Sbjct: 637 VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHL 696
Query: 154 LSHGANIAAVNSDGDLPLDLA---------------------------ESDAMEGLLKAE 186
L HGA + + DG L +A + D M LL A
Sbjct: 697 LDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAA 756
Query: 187 ----------IARRGVDVE-----------AAKRAEEELLLHDTRCWLNGGAMPEARHPR 225
+ G DV+ AA +++ W G A+
Sbjct: 757 YEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW--GAAVDSI--DS 812
Query: 226 TGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGG 285
G + L +A+A+G +EV+R LL G D RD GWTPLH AA G C L E G
Sbjct: 813 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGAR 872
Query: 286 MDSLTHAGQRPCDLADEE 303
+ + + G+ P LA +E
Sbjct: 873 TNEIDNDGRIPFILASQE 890
Score = 72.8 bits (177), Expect = 1e-12
Identities = 55/209 (26%), Positives = 94/209 (44%), Gaps = 27/209 (12%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D + DG++ L A + +++VV L+E GA V+ DN G TPL AAS G+ +
Sbjct: 739 AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVN 798
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRC 211
LL GA + +++S+G L +A + +++ + RG+D
Sbjct: 799 TLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT-LLDRGLD------------------ 839
Query: 212 WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWG 271
E G + LH+AA +G+ + L++ G D DG P A+ G
Sbjct: 840 --------ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEG 891
Query: 272 VEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
D ++L E+ +D + G+ +A
Sbjct: 892 HYDCVQILLENKSNIDQRGYDGRNALRVA 920
Score = 71.2 bits (173), Expect = 3e-12
Identities = 72/255 (28%), Positives = 107/255 (41%), Gaps = 56/255 (21%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ +++G + L A +L+VV LV +GA + D G TPL +AA G+ +
Sbjct: 536 ASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVN 595
Query: 152 YLLSHGANIAAVNSDG----------------------DLPLDLAESDAMEGLL------ 183
L+ GANI + DG + +D A++D+ L
Sbjct: 596 CLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGG 655
Query: 184 ----------------KAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHP--- 224
KA+ R + AA E++ H L+ GA E H
Sbjct: 656 HEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH----LLDHGA--EVNHEDVD 709
Query: 225 -RTGAS--ALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAE 281
RT S AL V A+KG+ V+ LL+ G + + D DG TPL AA+ G D LL E
Sbjct: 710 GRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLE 769
Query: 282 HGGGMDSLTHAGQRP 296
G +D + G+ P
Sbjct: 770 GGADVDHTDNNGRTP 784
Score = 70.9 bits (172), Expect = 4e-12
Identities = 59/184 (32%), Positives = 83/184 (45%), Gaps = 29/184 (15%)
Query: 112 ENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPL 171
E + +R L++ GA+VNQ D+ G T L AA G LD+ L+S GA++ ++ G PL
Sbjct: 523 EREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPL 582
Query: 172 DLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARH-PRTGASA 230
LA A +G K C + GA H + G +A
Sbjct: 583 TLA---ARQGHTKV-----------------------VNCLIGCGA--NINHTDQDGWTA 614
Query: 231 LHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLT 290
L AA G+ EV+ LL AG + D D T L AAA G ED L +HG ++
Sbjct: 615 LRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKAD 674
Query: 291 HAGQ 294
+ G+
Sbjct: 675 NEGR 678
Score = 57.0 bits (136), Expect = 7e-08
Identities = 104/479 (21%), Positives = 174/479 (36%), Gaps = 114/479 (23%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +++++A+G +ALH +C ++E+V+ L+ A VN ADNE + L AA G++ + +
Sbjct: 970 ANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQ 1029
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRC 211
L+ HGA + + G L +A A EG +DV +
Sbjct: 1030 LLIEHGAVVDHTCNQGATALCIA---AQEG---------HIDV--------------VQV 1063
Query: 212 WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWG 271
L GA P + G +A+ VAA G+ ++++LL + Y +G +P+H
Sbjct: 1064 LLEHGADPN-HADQFGRTAMRVAAKNGHSQIIKLLEK--YGASSLNGCSPSPVHTMEQKP 1120
Query: 272 VEDACRLL----------AEHGGG---------MDSLTHAGQRPCDLADEEVLSLLEELA 312
++ + GGG + THA P + D V L+
Sbjct: 1121 LQSLSSKVQSLTIKSNSSGSTGGGDMQPSLRGLPNGPTHAFSSPSESPDSTVDRQKSSLS 1180
Query: 313 RKQEDLRNQKEAS----QSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGA 368
L++ K +S S P S H LS E+I L + R
Sbjct: 1181 --NNSLKSSKNSSLRTTSSTATAQTVPIDSFH------NLSFTEQIQQHSLPRSRSRQSI 1232
Query: 369 GGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSS 428
P + G+ H SP S + + S LK+ +
Sbjct: 1233 VSPSSTTQSLGQS--------------------HNSPSSEFEWSQVKPS-----LKSTKA 1267
Query: 429 GALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSPKLPEPSVLSEV 488
G E G+ G ++S SS PK+ E +
Sbjct: 1268 SKGGKSENSAKSGSAGKKAKQSNSS----------------------QPKVLEYEMTQFD 1305
Query: 489 TKPPPCLENSSPPSRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPVRDEESESQRK 547
+ P ++ P + ES K +P+A ++ RS Q + ++S Q+K
Sbjct: 1306 RRGPIAKSGTAAPPKQMPAESQCKIMIPSA-------QQEIGRSQQQFLIHQQSGEQKK 1357
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 96.7 bits (239), Expect = 8e-20
Identities = 124/445 (27%), Positives = 178/445 (40%), Gaps = 75/445 (16%)
Query: 98 NADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHG 157
+ADG SALH A + +LE++ L+E ATV+ D+ G PLH AA G L+ R LL
Sbjct: 46 DADGFSALHHAALGGSLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRAS 105
Query: 158 ANIAAVNSDGDLPLDLAES----DAMEGLL----------KAEIARRGVDVEAAKRAEEE 203
A + A + DG +PL LA + E LL KA+ + E + +
Sbjct: 106 AAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQ 165
Query: 204 LLLHDTRC--WLNGGAMPEARHP--RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGD 259
LLL+ C L G EA+ P + LH+AA G+ EV+R LL+AG + +
Sbjct: 166 LLLNSHLCVALLEG----EAKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKT 221
Query: 260 GWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDL--------ADEEVLSLLEEL 311
G T LH AA +G + RLL E G ++ Q D+ A E+ LL E
Sbjct: 222 G-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREA 280
Query: 312 A-----RKQEDLRNQKEASQSRGQEPQAPSSSKHRRSSVCRL-----SSREKISLQDLSK 361
+ R +D N + P++ R V + R K + + +
Sbjct: 281 SGILKVRALKDFWNLHD-----------PTALNVRAGDVITVLEQHPDGRWKGHIHESQR 329
Query: 362 ERRPGGAGGPPIQDEDEGEEG------PTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAP 415
G P I + G P+ P P P + PP P P+ + P
Sbjct: 330 GTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRP-GFSRTPQPPAEEPPHPLTYSQLP 388
Query: 416 FSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSW-LEGTSTQAKELRLARITPT 474
R GL +G +R + G RSA S EGT+ L + P
Sbjct: 389 ---RVGLSPDSPAG-----DRNSVGSEGSVGSIRSAGSGQSSEGTNGHGPGLLIENAQPL 440
Query: 475 PS-------PKLPEPSVLSEVTKPP 492
PS P L PS+ ++ P
Sbjct: 441 PSAGEDQVLPGLHPPSLADNLSHRP 465
Score = 45.4 bits (106), Expect = 2e-04
Identities = 84/360 (23%), Positives = 119/360 (33%), Gaps = 98/360 (27%)
Query: 367 GAGGPP---IQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLL 423
G G PP + + PPP P + ++ PP P P P R L
Sbjct: 748 GQGPPPYVFMYPQGSPSSPAPGPPPGAPWAFSYLAGPPATPPDPP-----RPKRRSHSLS 802
Query: 424 KTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPS------- 476
+ G + E AEG G+ L A+ + G S + +TPTP+
Sbjct: 803 RPGPTEGDAEGE---AEGPVGSTLGSYATLTRRPGRSALVRTS--PSVTPTPARGTPRSQ 857
Query: 477 ----------PKLPEPSVLSEVT----KPPPCLENSSP------PSR--IPEPESPAKPN 514
P P P LS V+ +PPP E+ P P R + EP P++P
Sbjct: 858 SFALRARRKGPPPPPPKRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPP 917
Query: 515 VPTASTAPPADSRDRRRSYQ------------MPVRDE---------------------- 540
P A P +D+ + + +P +E
Sbjct: 918 GPPAPAGPASDTEEEEPGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPVP 977
Query: 541 --------ESESQR---KARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPESEKPAQSL- 588
ES++ + K R R Q+ GV A P PA SL
Sbjct: 978 PGLDFNLTESDTVKRRPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLP 1037
Query: 589 --DPSRRPRVPGVEN--SDSPAQRAEAPDGQGPGPQAAREHRKVGKEWRGPAEGEEAEPA 644
+PS P GV + SPA + P GPG +++ R W G E A A
Sbjct: 1038 QPEPSSLP-AQGVPTPLAPSPAMQPPVPPCPGPGLESSAASR-----WNGETEPPAAPAA 1091
Score = 42.4 bits (98), Expect = 0.002
Identities = 73/306 (23%), Positives = 96/306 (31%), Gaps = 41/306 (13%)
Query: 322 KEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG-AGGPPIQDEDEGE 380
K S G P+ P + R + + PG A P D +E E
Sbjct: 874 KRLSSVSGPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAGPASDTEEEE 933
Query: 381 EGPTEPPPAEPRTLNG--------VSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALG 432
GP PP+ + G ++ P P P E P T S
Sbjct: 934 PGPEGTPPSRGSSGEGLPFAEEGNLTIKQRPKPAGPPP-RETPVPPGLDFNLTESDTVKR 992
Query: 433 PPERRTAEGAPGAGLQRSASS----------SWLEGTSTQAKELRLARITPTPSPKLPEP 482
P+ R E A L +S S G S A L + P+ +P P
Sbjct: 993 RPKCREREPLQTALLAFGVASATPGPAAPLPSPTPGESPPASSLPQPEPSSLPAQGVPTP 1052
Query: 483 SVLSEVTKP--PPC----LENSSPPSRIPEPESPAKP----NVPTASTAPPADS------ 526
S +P PPC LE+S+ E E PA P VP A TAP S
Sbjct: 1053 LAPSPAMQPPVPPCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPVSVACTQL 1112
Query: 527 -----RDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKEAEKAAGKAPES 581
+ R PV ES +Q T L+ AEK+ G +
Sbjct: 1113 AFSGPKLAPRLGPRPVPPPRPESTGTVGPGQAQQRLEQTSSSLAAALRAAEKSIGTKEQE 1172
Query: 582 EKPAQS 587
P+ S
Sbjct: 1173 GTPSAS 1178
Score = 35.0 bits (79), Expect = 0.27
Identities = 58/232 (25%), Positives = 76/232 (32%), Gaps = 47/232 (20%)
Query: 473 PTPS---PKLPEPSVLSEVTKPPPCLENSSPPSRIP---------EPESPAKPNVPTAST 520
P PS P P+ L E T+ PP L +S P P P SPA P A
Sbjct: 717 PQPSGGDPSPPQERNLPEGTERPPKLCSSLPGQGPPPYVFMYPQGSPSSPAPGPPPGAPW 776
Query: 521 A----------PPADSRDRRRSYQMPVRDEESESQRKARSRLMRQSRRSTQGVTLTDLKE 570
A PP R +RRS+ + R +E + + G TL
Sbjct: 777 AFSYLAGPPATPPDPPRPKRRSHSLS-RPGPTEGDAEGEAE-------GPVGSTLGSYAT 828
Query: 571 AEKAAGK-APESEKPAQSLDPSRRPRVPGVENSDSPAQRAEAPDGQGPGPQAAREHRKVG 629
+ G+ A P+ + P+R G S S A RA +GP P + V
Sbjct: 829 LTRRPGRSALVRTSPSVTPTPAR-----GTPRSQSFALRARR---KGPPPPPPKRLSSVS 880
Query: 630 KEWRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQRDLNPEPEPESEEPDG 681
G EP + EG RR+ P P P G
Sbjct: 881 --------GPSPEPPPLDESPGPKEGATGPRRRTLSEPAGPSEPPGPPAPAG 924
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 96.3 bits (238), Expect = 1e-19
Identities = 117/443 (26%), Positives = 174/443 (39%), Gaps = 61/443 (13%)
Query: 90 ARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDI 149
A+A +D + G+ LH A E ++ +++ G+ VN +EG PLH+AA G+ D+
Sbjct: 71 AQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDV 130
Query: 150 ARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDT 209
+ LL H +N V++ G PLDLA E R GV +LLL
Sbjct: 131 SEMLLQHQSNPCMVDNSGKTPLDLA----------CEFGRVGV---------VQLLLSSN 171
Query: 210 RCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAH 269
C P G S LH+AA G+I+++RLLLQAG D + G T LH AA
Sbjct: 172 MCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAAL 230
Query: 270 WGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRG 329
G + RLL + G Q D+ + S + ++ LR A Q R
Sbjct: 231 CGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTS--QASREIKQLLREASAALQVR- 287
Query: 330 QEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPA 389
++K ++ S K E+ P G I D G + P +
Sbjct: 288 -------ATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSS 340
Query: 390 ---------------EPRTLNGVSSPPHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPP 434
EP G SS +P + + PF+ G ++GS +
Sbjct: 341 LGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFA---GGDRSGSISGM--- 394
Query: 435 ERRTAEGAPGAGLQRSASSSWLEGTSTQAKELRLARITPTPSP-KLPEPSVLSEVTKPPP 493
A G G A S ++ +T + ++ P SP K PE S ++PP
Sbjct: 395 ----AGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQPPV 450
Query: 494 C----LENSSPPSRIPEPESPAK 512
+ PP ++ EP S K
Sbjct: 451 AHAGQVYGEQPPKKL-EPASEGK 472
Score = 47.0 bits (110), Expect = 7e-05
Identities = 27/74 (36%), Positives = 41/74 (55%)
Query: 227 GASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGM 286
G SALH AA G E++ LLL+A +++D G PLH AA G ++ +L+ + G +
Sbjct: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAV 108
Query: 287 DSLTHAGQRPCDLA 300
+ + G P LA
Sbjct: 109 NIPSDEGHIPLHLA 122
Score = 43.9 bits (102), Expect = 6e-04
Identities = 66/238 (27%), Positives = 78/238 (32%), Gaps = 61/238 (25%)
Query: 319 RNQKEASQSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGGA-GGPPIQDED 377
R K + G EP P S H + R RRP GPP
Sbjct: 1150 RRPKAKEREAGPEPPPPLSVYHNGTGTVR---------------RRPASEQAGPP----- 1189
Query: 378 EGEEGPTEPPPAEPRTLNGVSSPPHPSP--------KSPV-------------QLEEAPF 416
E P PPPAEP + PP P P K PV Q P
Sbjct: 1190 ---ELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPT 1246
Query: 417 SRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWLEGTSTQAKEL--RLARITPT 474
S++ L GS PE + A G P + L A +P
Sbjct: 1247 SKKVPLPGPGS------PEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPA 1300
Query: 475 PSPKLPEPSVLSEVTKPPPCLENS--SPPS-RIPEPESPAKP-----NVPTASTAPPA 524
PSP P+ L++ PP L S PPS P PAKP A+ APPA
Sbjct: 1301 PSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPA 1358
Score = 38.5 bits (88), Expect = 0.024
Identities = 46/187 (24%), Positives = 66/187 (35%), Gaps = 26/187 (13%)
Query: 348 LSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSPPHPSPKS 407
L+ + + + +KER G PP+ G P +E + PP P+
Sbjct: 1142 LTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPP 1201
Query: 408 PVQLEEAPFSRRFGLLKTGSSGALGPPE---RRTAEGAPGAGLQRSASSSWLEGTSTQAK 464
P L P L PPE R+ A+ + L+G+ T
Sbjct: 1202 PTDLAHLP--------------PLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPT- 1246
Query: 465 ELRLARITPTPSPKLPEPSVLSEVTKPPPCLENSSPPSRIPEPESPAKPNVPTASTAP-P 523
++ P P P PE V PPP PP P+P A +P+ S P P
Sbjct: 1247 ----SKKVPLPGPGSPE--VKRAHGTPPPVSPKPPPPPTAPKPVK-AVAGLPSGSAGPSP 1299
Query: 524 ADSRDRR 530
A S R+
Sbjct: 1300 APSPARQ 1306
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 96.3 bits (238), Expect = 1e-19
Identities = 70/231 (30%), Positives = 108/231 (46%), Gaps = 37/231 (16%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P A+A+ +G + LH AC ++V+ L++ GA++ G TP+HVA
Sbjct: 387 LDKKANPNAKAL------NGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAE 201
A G+++I L+ HGA+ N G+ L +A +AE+ R
Sbjct: 441 AFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-----QAEVVR------------ 483
Query: 202 EELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGW 261
L+ D GA EA+ + + LH++A G ++++ LLQ G P G+
Sbjct: 484 --YLVQD-------GAQVEAK-AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 262 TPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADE----EVLSLL 308
TPLH +A G ED L +HG + T G P +A + EV +LL
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 94.7 bits (234), Expect = 3e-19
Identities = 74/229 (32%), Positives = 107/229 (46%), Gaps = 14/229 (6%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD AAP +L T +G+S LH A ++L V+ L++ V+ N+ T LHVA
Sbjct: 321 LDRAAP-----ILSKTK-NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVA 374
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLA----ESDAMEGLLKAEIARRGVDVEAA 197
A CG+ +A+ LL AN A +G PL +A ME LLK + + V
Sbjct: 375 AHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGL 434
Query: 198 KRAEEELLLHDTRC---WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPE 254
+ ++ GA P + R G +ALH+AA G EV+R L+Q G E
Sbjct: 435 TPIHVAAFMGHVNIVSQLMHHGASPNTTNVR-GETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 255 LRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
+ D TPLH +A G D + L + G ++ T +G P L+ E
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSARE 542
Score = 94.4 bits (233), Expect = 4e-19
Identities = 68/206 (33%), Positives = 91/206 (44%), Gaps = 27/206 (13%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++TN G +ALH A EVVR+LV+ GA V + TPLH++A G DI + LL
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA+ A + G PL L+ AR G + AA + L T
Sbjct: 520 QQGASPNAATTSGYTPLHLS-------------AREGHEDVAAFLLDHGASLSIT----- 561
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
+ G + LHVAA G +EV LLLQ P+ G TPLH AAH+ +
Sbjct: 562 ---------TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQK 612
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL + G + G P +A
Sbjct: 613 VALLLLDQGASPHAAAKNGYTPLHIA 638
Score = 87.4 bits (215), Expect = 5e-17
Identities = 65/216 (30%), Positives = 101/216 (46%), Gaps = 20/216 (9%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G +ALH A + EVV+ LV GA VN G+TPL++AA +L++ +
Sbjct: 98 ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVK 157
Query: 152 YLLSHGANIAAVNSDGDLPL--------DLAESDAMEGLLKAEIARRGVDVEAAK---RA 200
+LL +GA+ + DG PL D S +E K ++ + + A K +A
Sbjct: 158 FLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKA 217
Query: 201 EEELLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDG 260
LL +D + ++G + LH+AA G I V LLL + +
Sbjct: 218 AALLLQNDNNADVES---------KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 261 WTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
TPLH A+ G + +LL + G +D+ T G P
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTP 304
Score = 87.0 bits (214), Expect = 6e-17
Identities = 76/300 (25%), Positives = 134/300 (44%), Gaps = 24/300 (8%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D+ G++ LH A +N +V L++QGA+ + A G+TPLH+AA +DIA LL
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKR--------AEEELLL 206
+GA+ AV G + LA + ++ + R +V + + A +E +
Sbjct: 652 EYGADANAVTRQGIASVHLAAQEGHVDMVSL-LLGRNANVNLSNKSGLTPLHLAAQEDRV 710
Query: 207 HDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHA 266
+ +N GA +A+ + G + LHV G I+++ LLQ + +G+TPLH
Sbjct: 711 NVAEVLVNQGAHVDAQ-TKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQ 769
Query: 267 AAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADE-EVLSLLEELARKQEDLRNQKEAS 325
AA G +L ++ + LT G +A +S+++ L E+ +
Sbjct: 770 AAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVT 829
Query: 326 QSRGQEPQAPSSSKHRRSSVCRLSSREKISLQDLSKERRPGG-AGGPPIQDEDEGEEGPT 384
+ KH+ + ++ +S ++ K P + G I D +EGE+ T
Sbjct: 830 E------------KHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMT 877
Score = 81.3 bits (199), Expect = 3e-15
Identities = 60/212 (28%), Positives = 101/212 (47%), Gaps = 12/212 (5%)
Query: 98 NADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHG 157
N +G++ALH A + ++EVV L+++ A V+ A +G T LH+A+ G ++ + L+++G
Sbjct: 71 NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130
Query: 158 ANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLL-----HD--TR 210
AN+ A + +G PL +A + ++K + A + L + HD
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190
Query: 211 CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHW 270
L + R P ALH+AA K + LLLQ + ++ G+TPLH AAH+
Sbjct: 191 LLLENDTKGKVRLP-----ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHY 245
Query: 271 GVEDACRLLAEHGGGMDSLTHAGQRPCDLADE 302
G + LL +D P +A +
Sbjct: 246 GNINVATLLLNRAAAVDFTARNDITPLHVASK 277
Score = 75.9 bits (185), Expect = 1e-13
Identities = 59/212 (27%), Positives = 91/212 (42%), Gaps = 6/212 (2%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D + G + LH A N+ V L+ + A V+ TPLHVA+ G ++ + LL
Sbjct: 229 DVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLL 288
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA I A DG PL E +++ + R + K L + LN
Sbjct: 289 DRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 215 ------GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAA 268
+P +ALHVAA G+ +V ++LL +P + +G+TPLH A
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
Query: 269 HWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
LL +HG + ++T +G P +A
Sbjct: 409 KKNRIKVMELLLKHGASIQAVTESGLTPIHVA 440
Score = 57.8 bits (138), Expect = 4e-08
Identities = 30/83 (36%), Positives = 44/83 (53%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ +N G++ LH A ++ + V LV QGA V+ G+TPLHV G + I
Sbjct: 688 ANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 747
Query: 152 YLLSHGANIAAVNSDGDLPLDLA 174
+LL H A + A +G PL A
Sbjct: 748 FLLQHSAKVNAKTKNGYTPLHQA 770
Score = 52.4 bits (124), Expect = 2e-06
Identities = 28/83 (33%), Positives = 44/83 (53%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G + LH C N+++V FL++ A VN G+TPLH AA G+ I
Sbjct: 721 AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIIN 780
Query: 152 YLLSHGANIAAVNSDGDLPLDLA 174
LL + A+ + +G+ L +A
Sbjct: 781 VLLQNNASPNELTVNGNTALGIA 803
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/79 (29%), Positives = 44/79 (55%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G +ALH+A+ +G++EV+ LLQ + + G T LH A+ G + ++L +G
Sbjct: 72 QNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 285 GMDSLTHAGQRPCDLADEE 303
+++ + G P +A +E
Sbjct: 132 NVNAQSQNGFTPLYMAAQE 150
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 95.9 bits (237), Expect = 1e-19
Identities = 90/312 (28%), Positives = 128/312 (41%), Gaps = 34/312 (10%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G+ LH AC + EV LV+ GA VN AD +TPLH AA+ G +I + LL HGA+
Sbjct: 559 GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADP 618
Query: 161 AAVNSDGDLPLDLAE--SDAMEGLLKA-----EIARRGVDVEAAKRAEEELL-------L 206
N DG+ PLDL + ++ LL+ + A++G K + + +
Sbjct: 619 TKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGR 678
Query: 207 HDTRCWLNGG-------------AMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDP 253
H T L G + G LH AA+ G+++V LL++
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738
Query: 254 ELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELAR 313
D +TPLH AA G C LL HG GQ P DL + +S L A
Sbjct: 739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAM 798
Query: 314 KQEDLRNQKEAS-----QSRGQEPQAPSSSKHRRSSVCRLSSREKI--SLQDLSKERRPG 366
L + + +S G A SS SS+ SS + + S +LS
Sbjct: 799 PPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGSFSELSSVVSSS 858
Query: 367 GAGGPPIQDEDE 378
G G ++ E
Sbjct: 859 GTEGASSLEKKE 870
Score = 95.5 bits (236), Expect = 2e-19
Identities = 63/194 (32%), Positives = 98/194 (50%), Gaps = 16/194 (8%)
Query: 101 GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANI 160
G+ LH AC + EVV L+ GA N DN +TPLH AA G +D+ LL HGA
Sbjct: 91 GLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEP 150
Query: 161 AAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH-----DTRCWLNG 215
N+DG LDLA+ A + +L E + + +E+A+ EE ++ + C +
Sbjct: 151 TIRNTDGRTALDLADPSA-KAVLTGEYKKDEL-LESARSGNEEKMMALLTPLNVNCHASD 208
Query: 216 GAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDA 275
G ++ LH+AA +++++LLLQ G D +D PLH A +G +
Sbjct: 209 GRK---------STPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEV 259
Query: 276 CRLLAEHGGGMDSL 289
LL +HG ++++
Sbjct: 260 TELLVKHGACVNAM 273
Score = 83.2 bits (204), Expect = 9e-16
Identities = 59/193 (30%), Positives = 95/193 (49%), Gaps = 9/193 (4%)
Query: 105 LHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVN 164
LH AC + EV LV+ GA VN D +TPLH AAS +++ LLS+GA+ +N
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLN 307
Query: 165 SDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEARHP 224
+DLA + ++ L E + ++AA+ A+ + M +HP
Sbjct: 308 CHNKSAIDLAPTPQLKERLAYEFKGHSL-LQAAREADVTRIKKHLSL-----EMVNFKHP 361
Query: 225 RTGASALHVAAAKGY---IEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAE 281
+T +ALH AAA Y ++ LLL+ G + + + TPLH A+ D ++ +
Sbjct: 362 QTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421
Query: 282 HGGGMDSLTHAGQ 294
H +++L + GQ
Sbjct: 422 HEAKVNALDNLGQ 434
Score = 77.0 bits (188), Expect = 6e-14
Identities = 72/255 (28%), Positives = 107/255 (41%), Gaps = 40/255 (15%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ + ++ LH A + +VV +V+ A VN DN G T LH AA CG+L R
Sbjct: 391 ANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCR 450
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKA-------------EIARRGVDVEAAK 198
LLS+G + ++ G L + + + L + E A+ G DVE K
Sbjct: 451 LLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAG-DVETVK 509
Query: 199 R-------------AEEELLLHDTRCW---------LNGGAMPEARHPRTGASALHVAAA 236
+ + LH + L GA A+ + G LH A +
Sbjct: 510 KLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAK-DKGGLVPLHNACS 568
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
G+ EV LL++ G + D +TPLH AA G + C+LL +HG G P
Sbjct: 569 YGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTP 628
Query: 297 CDL---ADEEVLSLL 308
DL D ++ LL
Sbjct: 629 LDLVKDGDTDIQDLL 643
Score = 67.0 bits (162), Expect = 6e-11
Identities = 63/226 (27%), Positives = 90/226 (39%), Gaps = 63/226 (27%)
Query: 105 LHQACIDENLEVVRFLVEQGATVNQADNEGW--TPLHVAASCGYLDIARYLLSHGANIAA 162
L +AC + ++E V+ LV VN D G TPLH AA G D+ YLL
Sbjct: 28 LFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLL-------- 78
Query: 163 VNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLNGGAMPEAR 222
+ G +V+A +GG +P
Sbjct: 79 --------------------------QNGANVQARD---------------DGGLIP--- 94
Query: 223 HPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEH 282
LH A + G+ EV+ LLL+ G DP RD +TPLH AA G D C +L +H
Sbjct: 95 --------LHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
Query: 283 GGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSR 328
G G+ DLAD ++L +K E L + + ++ +
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEK 192
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/94 (35%), Positives = 50/94 (53%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +++ + G+ LH A +++V L++ A VN D +TPLH AA G +
Sbjct: 703 ADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA 762
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKA 185
LL+HGA+ N +G PLDL +D + LL A
Sbjct: 763 LLLAHGADPTLKNQEGQTPLDLVSADDVSALLTA 796
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/244 (29%), Positives = 110/244 (45%), Gaps = 37/244 (15%)
Query: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152
+L++T G +ALH A + EVVR LV GA VN +G+TPL++AA +L++ ++
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLL--------KAEIARRGVDVEAAK---RAE 201
LL +GAN DG PL +A E ++ K ++ + + A R
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222
Query: 202 EELLLHD-------------------------TRCWLNGGAMPEARHPRTGASALHVAAA 236
LL +D + LN GA P+ G + LH+A+
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASR 281
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
+G + ++RLLL G E + D TPLH AA G +L +HG + + T G P
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
Query: 297 CDLA 300
+A
Sbjct: 342 IHMA 345
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/267 (26%), Positives = 115/267 (43%), Gaps = 9/267 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G++ LH A +L +V+ L+++GA+ N ++ + TPLH+AA G+ ++A+
Sbjct: 428 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 487
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH---- 207
YLL + A + A D PL A ++K + A L +
Sbjct: 488 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 547
Query: 208 --DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
+T L +A + G + LHVAA G + V LLL+ P +G TPLH
Sbjct: 548 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 607
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAS 325
A H D +LL GG S G P +A ++ E+AR A
Sbjct: 608 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQYGGSANAE 664
Query: 326 QSRGQEPQAPSSSKHRRSSVCRLSSRE 352
+G P ++ + V L S++
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Score = 83.2 bits (204), Expect = 9e-16
Identities = 71/208 (34%), Positives = 96/208 (46%), Gaps = 31/208 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D + G + LH A ENL V + L+ +GA+VN G TPLH+A+ G + + R LL
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 292
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA I D PL A AR G R E LL H
Sbjct: 293 DRGAQIETKTKDELTPLHCA-------------ARNG-----HVRISEILLDH------- 327
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRD--GDGWTPLHAAAHWGV 272
GA +A+ + G S +H+AA +++ +RLLLQ YD E+ D D TPLH AAH G
Sbjct: 328 -GAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITLDHLTPLHVAAHCGH 383
Query: 273 EDACRLLAEHGGGMDSLTHAGQRPCDLA 300
++L + G +S G P +A
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIA 411
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 24/231 (10%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P +RA+ +G + LH AC ++ V+ L++ GA+++ G TPLHVA
Sbjct: 391 LDKGAKPNSRAL------NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 444
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEA---AK 198
+ G+L I + LL GA+ N + PL +A A G E+A+ + +A AK
Sbjct: 445 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA---ARAG--HTEVAKYLLQNKAKVNAK 499
Query: 199 RAEEELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQA 249
+++ LH + L A P G + LH+AA +G++E + LL+
Sbjct: 500 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLA-TTAGHTPLHIAAREGHVETVLALLEK 558
Query: 250 GYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
G+TPLH AA +G LL E ++ G P +A
Sbjct: 559 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609
Score = 82.4 bits (202), Expect = 1e-15
Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 27/209 (12%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++ +G++ LH A NL++V+ L+ +G + + G+TPLH+AA +++AR LL
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
+G + A + G PL LA A EG AE LL + N
Sbjct: 656 QYGGSANAESVQGVTPLHLA---AQEG-----------------HAEMVALLLSKQANGN 695
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
G ++G + LH+ A +G++ V +L++ G + G+TPLH A+H+G
Sbjct: 696 LGN-------KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
+ L +H +++ T G P A ++
Sbjct: 749 LVKFLLQHQADVNAKTKLGYSPLHQAAQQ 777
Score = 80.5 bits (197), Expect = 6e-15
Identities = 64/199 (32%), Positives = 96/199 (48%), Gaps = 8/199 (4%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ T +GI+ LH A N+ +VR L+++GA + + TPLH AA G++ I+
Sbjct: 263 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 322
Query: 152 YLLSHGANIAAVNSDGDLPLDLAES----DAMEGLLK--AEIARRGVDVEAAKRAEEELL 205
LL HGA I A +G P+ +A D + LL+ AEI +D
Sbjct: 323 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 382
Query: 206 LHD-TRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
H + L+ GA P +R G + LH+A K ++ VM LLL+ G + G TPL
Sbjct: 383 HHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 441
Query: 265 HAAAHWGVEDACRLLAEHG 283
H A+ G + L + G
Sbjct: 442 HVASFMGHLPIVKNLLQRG 460
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/203 (30%), Positives = 91/203 (44%), Gaps = 31/203 (15%)
Query: 100 DGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
+G + LH A +EV R L++ G + N +G TPLH+AA G+ ++ LLS AN
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 693
Query: 160 IAAVNSDGDLPLDLAESDAMEGLLKAE--IARRGVDVEAAKRAEEELLLHDTRCWLNGGA 217
N G PL L A EG + + + GV V+A
Sbjct: 694 GNLGNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDAT-------------------- 730
Query: 218 MPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACR 277
R G + LHVA+ G I++++ LLQ D + G++PLH AA G D
Sbjct: 731 ------TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 784
Query: 278 LLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++ G P +A
Sbjct: 785 LLLKNGASPNEVSSDGTTPLAIA 807
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/188 (29%), Positives = 83/188 (44%), Gaps = 33/188 (17%)
Query: 90 ARAVLD---STNAD---GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAAS 143
AR++L S NA+ G++ LH A + + E+V L+ + A N + G TPLH+ A
Sbjct: 651 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 710
Query: 144 CGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEE 203
G++ +A L+ HG + A G PL +A L+K + + DV A
Sbjct: 711 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF-LLQHQADVNA------- 762
Query: 204 LLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTP 263
+ G S LH AA +G+ +++ LLL+ G P DG TP
Sbjct: 763 -------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 803
Query: 264 LHAAAHWG 271
L A G
Sbjct: 804 LAIAKRLG 811
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/124 (26%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G + LH+A+ +G+++++ LL E G T LH AA G ++ R L +G
Sbjct: 76 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 135
Query: 285 GMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSS 344
+++ + G P +A +E + LE + E+ NQ A++ G P A + + +
Sbjct: 136 NVNAQSQKGFTPLYMAAQE--NHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENV 192
Query: 345 VCRL 348
V L
Sbjct: 193 VAHL 196
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/244 (29%), Positives = 110/244 (45%), Gaps = 37/244 (15%)
Query: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152
+L++T G +ALH A + EVVR LV GA VN +G+TPL++AA +L++ ++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLL--------KAEIARRGVDVEAAK---RAE 201
LL +GAN DG PL +A E ++ K ++ + + A R
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 202 EELLLHD-------------------------TRCWLNGGAMPEARHPRTGASALHVAAA 236
LL +D + LN GA P+ G + LH+A+
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASR 248
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
+G + ++RLLL G E + D TPLH AA G +L +HG + + T G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 297 CDLA 300
+A
Sbjct: 309 IHMA 312
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/267 (26%), Positives = 115/267 (43%), Gaps = 9/267 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G++ LH A +L +V+ L+++GA+ N ++ + TPLH+AA G+ ++A+
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH---- 207
YLL + A + A D PL A ++K + A L +
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 208 --DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
+T L +A + G + LHVAA G + V LLL+ P +G TPLH
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAS 325
A H D +LL GG S G P +A ++ E+AR A
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQYGGSANAE 631
Query: 326 QSRGQEPQAPSSSKHRRSSVCRLSSRE 352
+G P ++ + V L S++
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 83.2 bits (204), Expect = 9e-16
Identities = 71/208 (34%), Positives = 96/208 (46%), Gaps = 31/208 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D + G + LH A ENL V + L+ +GA+VN G TPLH+A+ G + + R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA I D PL A AR G R E LL H
Sbjct: 260 DRGAQIETKTKDELTPLHCA-------------ARNG-----HVRISEILLDH------- 294
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRD--GDGWTPLHAAAHWGV 272
GA +A+ + G S +H+AA +++ +RLLLQ YD E+ D D TPLH AAH G
Sbjct: 295 -GAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITLDHLTPLHVAAHCGH 350
Query: 273 EDACRLLAEHGGGMDSLTHAGQRPCDLA 300
++L + G +S G P +A
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 24/231 (10%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P +RA+ +G + LH AC ++ V+ L++ GA+++ G TPLHVA
Sbjct: 358 LDKGAKPNSRAL------NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEA---AK 198
+ G+L I + LL GA+ N + PL +A A G E+A+ + +A AK
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA---ARAG--HTEVAKYLLQNKAKVNAK 466
Query: 199 RAEEELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQA 249
+++ LH + L A P G + LH+AA +G++E + LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLA-TTAGHTPLHIAAREGHVETVLALLEK 525
Query: 250 GYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
G+TPLH AA +G LL E ++ G P +A
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.4 bits (202), Expect = 1e-15
Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 27/209 (12%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++ +G++ LH A NL++V+ L+ +G + + G+TPLH+AA +++AR LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
+G + A + G PL LA A EG AE LL + N
Sbjct: 623 QYGGSANAESVQGVTPLHLA---AQEG-----------------HAEMVALLLSKQANGN 662
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
G ++G + LH+ A +G++ V +L++ G + G+TPLH A+H+G
Sbjct: 663 LGN-------KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
+ L +H +++ T G P A ++
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Score = 80.5 bits (197), Expect = 6e-15
Identities = 64/199 (32%), Positives = 96/199 (48%), Gaps = 8/199 (4%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ T +GI+ LH A N+ +VR L+++GA + + TPLH AA G++ I+
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 152 YLLSHGANIAAVNSDGDLPLDLAES----DAMEGLLK--AEIARRGVDVEAAKRAEEELL 205
LL HGA I A +G P+ +A D + LL+ AEI +D
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 206 LHD-TRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
H + L+ GA P +R G + LH+A K ++ VM LLL+ G + G TPL
Sbjct: 350 HHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 265 HAAAHWGVEDACRLLAEHG 283
H A+ G + L + G
Sbjct: 409 HVASFMGHLPIVKNLLQRG 427
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/203 (30%), Positives = 91/203 (44%), Gaps = 31/203 (15%)
Query: 100 DGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
+G + LH A +EV R L++ G + N +G TPLH+AA G+ ++ LLS AN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 160 IAAVNSDGDLPLDLAESDAMEGLLKAE--IARRGVDVEAAKRAEEELLLHDTRCWLNGGA 217
N G PL L A EG + + + GV V+A
Sbjct: 661 GNLGNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDAT-------------------- 697
Query: 218 MPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACR 277
R G + LHVA+ G I++++ LLQ D + G++PLH AA G D
Sbjct: 698 ------TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 751
Query: 278 LLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++ G P +A
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/188 (29%), Positives = 83/188 (44%), Gaps = 33/188 (17%)
Query: 90 ARAVLD---STNAD---GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAAS 143
AR++L S NA+ G++ LH A + + E+V L+ + A N + G TPLH+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 144 CGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEE 203
G++ +A L+ HG + A G PL +A L+K + + DV A
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF-LLQHQADVNA------- 729
Query: 204 LLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTP 263
+ G S LH AA +G+ +++ LLL+ G P DG TP
Sbjct: 730 -------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Query: 264 LHAAAHWG 271
L A G
Sbjct: 771 LAIAKRLG 778
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/124 (26%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G + LH+A+ +G+++++ LL E G T LH AA G ++ R L +G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 285 GMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSS 344
+++ + G P +A +E + LE + E+ NQ A++ G P A + + +
Sbjct: 103 NVNAQSQKGFTPLYMAAQE--NHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENV 159
Query: 345 VCRL 348
V L
Sbjct: 160 VAHL 163
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/244 (29%), Positives = 110/244 (45%), Gaps = 37/244 (15%)
Query: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152
+L++T G +ALH A + EVVR LV GA VN +G+TPL++AA +L++ ++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLL--------KAEIARRGVDVEAAK---RAE 201
LL +GAN DG PL +A E ++ K ++ + + A R
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 202 EELLLHD-------------------------TRCWLNGGAMPEARHPRTGASALHVAAA 236
LL +D + LN GA P+ G + LH+A+
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASR 248
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
+G + ++RLLL G E + D TPLH AA G +L +HG + + T G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 297 CDLA 300
+A
Sbjct: 309 IHMA 312
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/267 (26%), Positives = 115/267 (43%), Gaps = 9/267 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G++ LH A +L +V+ L+++GA+ N ++ + TPLH+AA G+ ++A+
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH---- 207
YLL + A + A D PL A ++K + A L +
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 208 --DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
+T L +A + G + LHVAA G + V LLL+ P +G TPLH
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAS 325
A H D +LL GG S G P +A ++ E+AR A
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQYGGSANAE 631
Query: 326 QSRGQEPQAPSSSKHRRSSVCRLSSRE 352
+G P ++ + V L S++
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 83.2 bits (204), Expect = 9e-16
Identities = 71/208 (34%), Positives = 96/208 (46%), Gaps = 31/208 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D + G + LH A ENL V + L+ +GA+VN G TPLH+A+ G + + R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA I D PL A AR G R E LL H
Sbjct: 260 DRGAQIETKTKDELTPLHCA-------------ARNG-----HVRISEILLDH------- 294
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRD--GDGWTPLHAAAHWGV 272
GA +A+ + G S +H+AA +++ +RLLLQ YD E+ D D TPLH AAH G
Sbjct: 295 -GAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITLDHLTPLHVAAHCGH 350
Query: 273 EDACRLLAEHGGGMDSLTHAGQRPCDLA 300
++L + G +S G P +A
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 24/231 (10%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P +RA+ +G + LH AC ++ V+ L++ GA+++ G TPLHVA
Sbjct: 358 LDKGAKPNSRAL------NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEA---AK 198
+ G+L I + LL GA+ N + PL +A A G E+A+ + +A AK
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA---ARAG--HTEVAKYLLQNKAKVNAK 466
Query: 199 RAEEELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQA 249
+++ LH + L A P G + LH+AA +G++E + LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLA-TTAGHTPLHIAAREGHVETVLALLEK 525
Query: 250 GYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
G+TPLH AA +G LL E ++ G P +A
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.4 bits (202), Expect = 1e-15
Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 27/209 (12%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++ +G++ LH A NL++V+ L+ +G + + G+TPLH+AA +++AR LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
+G + A + G PL LA A EG AE LL + N
Sbjct: 623 QYGGSANAESVQGVTPLHLA---AQEG-----------------HAEMVALLLSKQANGN 662
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
G ++G + LH+ A +G++ V +L++ G + G+TPLH A+H+G
Sbjct: 663 LGN-------KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
+ L +H +++ T G P A ++
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Score = 80.5 bits (197), Expect = 6e-15
Identities = 64/199 (32%), Positives = 96/199 (48%), Gaps = 8/199 (4%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ T +GI+ LH A N+ +VR L+++GA + + TPLH AA G++ I+
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 152 YLLSHGANIAAVNSDGDLPLDLAES----DAMEGLLK--AEIARRGVDVEAAKRAEEELL 205
LL HGA I A +G P+ +A D + LL+ AEI +D
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 206 LHD-TRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
H + L+ GA P +R G + LH+A K ++ VM LLL+ G + G TPL
Sbjct: 350 HHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 265 HAAAHWGVEDACRLLAEHG 283
H A+ G + L + G
Sbjct: 409 HVASFMGHLPIVKNLLQRG 427
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/203 (30%), Positives = 91/203 (44%), Gaps = 31/203 (15%)
Query: 100 DGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
+G + LH A +EV R L++ G + N +G TPLH+AA G+ ++ LLS AN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 160 IAAVNSDGDLPLDLAESDAMEGLLKAE--IARRGVDVEAAKRAEEELLLHDTRCWLNGGA 217
N G PL L A EG + + + GV V+A
Sbjct: 661 GNLGNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDAT-------------------- 697
Query: 218 MPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACR 277
R G + LHVA+ G I++++ LLQ D + G++PLH AA G D
Sbjct: 698 ------TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 751
Query: 278 LLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++ G P +A
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/188 (29%), Positives = 83/188 (44%), Gaps = 33/188 (17%)
Query: 90 ARAVLD---STNAD---GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAAS 143
AR++L S NA+ G++ LH A + + E+V L+ + A N + G TPLH+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 144 CGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEE 203
G++ +A L+ HG + A G PL +A L+K + + DV A
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF-LLQHQADVNA------- 729
Query: 204 LLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTP 263
+ G S LH AA +G+ +++ LLL+ G P DG TP
Sbjct: 730 -------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Query: 264 LHAAAHWG 271
L A G
Sbjct: 771 LAIAKRLG 778
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/124 (26%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G + LH+A+ +G+++++ LL E G T LH AA G ++ R L +G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 285 GMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSS 344
+++ + G P +A +E + LE + E+ NQ A++ G P A + + +
Sbjct: 103 NVNAQSQKGFTPLYMAAQE--NHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENV 159
Query: 345 VCRL 348
V L
Sbjct: 160 VAHL 163
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/244 (29%), Positives = 110/244 (45%), Gaps = 37/244 (15%)
Query: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152
+L++T G +ALH A + EVVR LV GA VN +G+TPL++AA +L++ ++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLL--------KAEIARRGVDVEAAK---RAE 201
LL +GAN DG PL +A E ++ K ++ + + A R
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 202 EELLLHD-------------------------TRCWLNGGAMPEARHPRTGASALHVAAA 236
LL +D + LN GA P+ G + LH+A+
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASR 248
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
+G + ++RLLL G E + D TPLH AA G +L +HG + + T G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 297 CDLA 300
+A
Sbjct: 309 IHMA 312
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/267 (26%), Positives = 115/267 (43%), Gaps = 9/267 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G++ LH A +L +V+ L+++GA+ N ++ + TPLH+AA G+ ++A+
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH---- 207
YLL + A + A D PL A ++K + A L +
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 208 --DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
+T L +A + G + LHVAA G + V LLL+ P +G TPLH
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAS 325
A H D +LL GG S G P +A ++ E+AR A
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQYGGSANAE 631
Query: 326 QSRGQEPQAPSSSKHRRSSVCRLSSRE 352
+G P ++ + V L S++
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 83.2 bits (204), Expect = 9e-16
Identities = 71/208 (34%), Positives = 96/208 (46%), Gaps = 31/208 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D + G + LH A ENL V + L+ +GA+VN G TPLH+A+ G + + R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA I D PL A AR G R E LL H
Sbjct: 260 DRGAQIETKTKDELTPLHCA-------------ARNG-----HVRISEILLDH------- 294
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRD--GDGWTPLHAAAHWGV 272
GA +A+ + G S +H+AA +++ +RLLLQ YD E+ D D TPLH AAH G
Sbjct: 295 -GAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITLDHLTPLHVAAHCGH 350
Query: 273 EDACRLLAEHGGGMDSLTHAGQRPCDLA 300
++L + G +S G P +A
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 24/231 (10%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P +RA+ +G + LH AC ++ V+ L++ GA+++ G TPLHVA
Sbjct: 358 LDKGAKPNSRAL------NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEA---AK 198
+ G+L I + LL GA+ N + PL +A A G E+A+ + +A AK
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA---ARAG--HTEVAKYLLQNKAKVNAK 466
Query: 199 RAEEELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQA 249
+++ LH + L A P G + LH+AA +G++E + LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLA-TTAGHTPLHIAAREGHVETVLALLEK 525
Query: 250 GYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
G+TPLH AA +G LL E ++ G P +A
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.4 bits (202), Expect = 1e-15
Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 27/209 (12%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++ +G++ LH A NL++V+ L+ +G + + G+TPLH+AA +++AR LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
+G + A + G PL LA A EG AE LL + N
Sbjct: 623 QYGGSANAESVQGVTPLHLA---AQEG-----------------HAEMVALLLSKQANGN 662
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
G ++G + LH+ A +G++ V +L++ G + G+TPLH A+H+G
Sbjct: 663 LGN-------KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
+ L +H +++ T G P A ++
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Score = 80.5 bits (197), Expect = 6e-15
Identities = 64/199 (32%), Positives = 96/199 (48%), Gaps = 8/199 (4%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ T +GI+ LH A N+ +VR L+++GA + + TPLH AA G++ I+
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 152 YLLSHGANIAAVNSDGDLPLDLAES----DAMEGLLK--AEIARRGVDVEAAKRAEEELL 205
LL HGA I A +G P+ +A D + LL+ AEI +D
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 206 LHD-TRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
H + L+ GA P +R G + LH+A K ++ VM LLL+ G + G TPL
Sbjct: 350 HHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 265 HAAAHWGVEDACRLLAEHG 283
H A+ G + L + G
Sbjct: 409 HVASFMGHLPIVKNLLQRG 427
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/203 (30%), Positives = 91/203 (44%), Gaps = 31/203 (15%)
Query: 100 DGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
+G + LH A +EV R L++ G + N +G TPLH+AA G+ ++ LLS AN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 160 IAAVNSDGDLPLDLAESDAMEGLLKAE--IARRGVDVEAAKRAEEELLLHDTRCWLNGGA 217
N G PL L A EG + + + GV V+A
Sbjct: 661 GNLGNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDAT-------------------- 697
Query: 218 MPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACR 277
R G + LHVA+ G I++++ LLQ D + G++PLH AA G D
Sbjct: 698 ------TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 751
Query: 278 LLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++ G P +A
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/188 (29%), Positives = 83/188 (44%), Gaps = 33/188 (17%)
Query: 90 ARAVLD---STNAD---GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAAS 143
AR++L S NA+ G++ LH A + + E+V L+ + A N + G TPLH+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 144 CGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEE 203
G++ +A L+ HG + A G PL +A L+K + + DV A
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF-LLQHQADVNA------- 729
Query: 204 LLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTP 263
+ G S LH AA +G+ +++ LLL+ G P DG TP
Sbjct: 730 -------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Query: 264 LHAAAHWG 271
L A G
Sbjct: 771 LAIAKRLG 778
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/124 (26%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G + LH+A+ +G+++++ LL E G T LH AA G ++ R L +G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 285 GMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSS 344
+++ + G P +A +E + LE + E+ NQ A++ G P A + + +
Sbjct: 103 NVNAQSQKGFTPLYMAAQE--NHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENV 159
Query: 345 VCRL 348
V L
Sbjct: 160 VAHL 163
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 94.4 bits (233), Expect = 4e-19
Identities = 72/244 (29%), Positives = 110/244 (45%), Gaps = 37/244 (15%)
Query: 93 VLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARY 152
+L++T G +ALH A + EVVR LV GA VN +G+TPL++AA +L++ ++
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 153 LLSHGANIAAVNSDGDLPLDLAESDAMEGLL--------KAEIARRGVDVEAAK---RAE 201
LL +GAN DG PL +A E ++ K ++ + + A R
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 202 EELLLHD-------------------------TRCWLNGGAMPEARHPRTGASALHVAAA 236
LL +D + LN GA P+ G + LH+A+
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT-PQNGITPLHIASR 248
Query: 237 KGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRP 296
+G + ++RLLL G E + D TPLH AA G +L +HG + + T G P
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 297 CDLA 300
+A
Sbjct: 309 IHMA 312
Score = 88.6 bits (218), Expect = 2e-17
Identities = 72/267 (26%), Positives = 115/267 (43%), Gaps = 9/267 (3%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A +D+ G++ LH A +L +V+ L+++GA+ N ++ + TPLH+AA G+ ++A+
Sbjct: 395 ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAK 454
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH---- 207
YLL + A + A D PL A ++K + A L +
Sbjct: 455 YLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREG 514
Query: 208 --DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
+T L +A + G + LHVAA G + V LLL+ P +G TPLH
Sbjct: 515 HVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEAS 325
A H D +LL GG S G P +A ++ E+AR A
Sbjct: 575 VAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQ---NQVEVARSLLQYGGSANAE 631
Query: 326 QSRGQEPQAPSSSKHRRSSVCRLSSRE 352
+G P ++ + V L S++
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Score = 83.2 bits (204), Expect = 9e-16
Identities = 71/208 (34%), Positives = 96/208 (46%), Gaps = 31/208 (14%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
D + G + LH A ENL V + L+ +GA+VN G TPLH+A+ G + + R LL
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
GA I D PL A AR G R E LL H
Sbjct: 260 DRGAQIETKTKDELTPLHCA-------------ARNG-----HVRISEILLDH------- 294
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRD--GDGWTPLHAAAHWGV 272
GA +A+ + G S +H+AA +++ +RLLLQ YD E+ D D TPLH AAH G
Sbjct: 295 -GAPIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQ--YDAEIDDITLDHLTPLHVAAHCGH 350
Query: 273 EDACRLLAEHGGGMDSLTHAGQRPCDLA 300
++L + G +S G P +A
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 83.2 bits (204), Expect = 9e-16
Identities = 68/231 (29%), Positives = 106/231 (45%), Gaps = 24/231 (10%)
Query: 82 LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141
LD A P +RA+ +G + LH AC ++ V+ L++ GA+++ G TPLHVA
Sbjct: 358 LDKGAKPNSRAL------NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Query: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEA---AK 198
+ G+L I + LL GA+ N + PL +A A G E+A+ + +A AK
Sbjct: 412 SFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA---ARAG--HTEVAKYLLQNKAKVNAK 466
Query: 199 RAEEELLLH---------DTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQA 249
+++ LH + L A P G + LH+AA +G++E + LL+
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLA-TTAGHTPLHIAAREGHVETVLALLEK 525
Query: 250 GYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
G+TPLH AA +G LL E ++ G P +A
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 82.4 bits (202), Expect = 1e-15
Identities = 58/209 (27%), Positives = 100/209 (47%), Gaps = 27/209 (12%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
++ +G++ LH A NL++V+ L+ +G + + G+TPLH+AA +++AR LL
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 155 SHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTRCWLN 214
+G + A + G PL LA A EG AE LL + N
Sbjct: 623 QYGGSANAESVQGVTPLHLA---AQEG-----------------HAEMVALLLSKQANGN 662
Query: 215 GGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVED 274
G ++G + LH+ A +G++ V +L++ G + G+TPLH A+H+G
Sbjct: 663 LGN-------KSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 275 ACRLLAEHGGGMDSLTHAGQRPCDLADEE 303
+ L +H +++ T G P A ++
Sbjct: 716 LVKFLLQHQADVNAKTKLGYSPLHQAAQQ 744
Score = 80.5 bits (197), Expect = 6e-15
Identities = 64/199 (32%), Positives = 96/199 (48%), Gaps = 8/199 (4%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIAR 151
A ++ T +GI+ LH A N+ +VR L+++GA + + TPLH AA G++ I+
Sbjct: 230 ASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISE 289
Query: 152 YLLSHGANIAAVNSDGDLPLDLAES----DAMEGLLK--AEIARRGVDVEAAKRAEEELL 205
LL HGA I A +G P+ +A D + LL+ AEI +D
Sbjct: 290 ILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCG 349
Query: 206 LHD-TRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPL 264
H + L+ GA P +R G + LH+A K ++ VM LLL+ G + G TPL
Sbjct: 350 HHRVAKVLLDKGAKPNSR-ALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPL 408
Query: 265 HAAAHWGVEDACRLLAEHG 283
H A+ G + L + G
Sbjct: 409 HVASFMGHLPIVKNLLQRG 427
Score = 77.4 bits (189), Expect = 5e-14
Identities = 61/203 (30%), Positives = 91/203 (44%), Gaps = 31/203 (15%)
Query: 100 DGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGAN 159
+G + LH A +EV R L++ G + N +G TPLH+AA G+ ++ LLS AN
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQAN 660
Query: 160 IAAVNSDGDLPLDLAESDAMEGLLKAE--IARRGVDVEAAKRAEEELLLHDTRCWLNGGA 217
N G PL L A EG + + + GV V+A
Sbjct: 661 GNLGNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDAT-------------------- 697
Query: 218 MPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACR 277
R G + LHVA+ G I++++ LLQ D + G++PLH AA G D
Sbjct: 698 ------TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 751
Query: 278 LLAEHGGGMDSLTHAGQRPCDLA 300
LL ++G + ++ G P +A
Sbjct: 752 LLLKNGASPNEVSSDGTTPLAIA 774
Score = 67.4 bits (163), Expect = 5e-11
Identities = 55/188 (29%), Positives = 83/188 (44%), Gaps = 33/188 (17%)
Query: 90 ARAVLD---STNAD---GISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAAS 143
AR++L S NA+ G++ LH A + + E+V L+ + A N + G TPLH+ A
Sbjct: 618 ARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQ 677
Query: 144 CGYLDIARYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEE 203
G++ +A L+ HG + A G PL +A L+K + + DV A
Sbjct: 678 EGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKF-LLQHQADVNA------- 729
Query: 204 LLLHDTRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTP 263
+ G S LH AA +G+ +++ LLL+ G P DG TP
Sbjct: 730 -------------------KTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTP 770
Query: 264 LHAAAHWG 271
L A G
Sbjct: 771 LAIAKRLG 778
Score = 39.7 bits (91), Expect = 0.011
Identities = 33/124 (26%), Positives = 60/124 (48%), Gaps = 3/124 (2%)
Query: 225 RTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGG 284
+ G + LH+A+ +G+++++ LL E G T LH AA G ++ R L +G
Sbjct: 43 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 102
Query: 285 GMDSLTHAGQRPCDLADEEVLSLLEELARKQEDLRNQKEASQSRGQEPQAPSSSKHRRSS 344
+++ + G P +A +E + LE + E+ NQ A++ G P A + + +
Sbjct: 103 NVNAQSQKGFTPLYMAAQE--NHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENV 159
Query: 345 VCRL 348
V L
Sbjct: 160 VAHL 163
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 88.2 bits (217), Expect = 3e-17
Identities = 73/232 (31%), Positives = 108/232 (46%), Gaps = 14/232 (6%)
Query: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYL 153
LD + G ALH A + +V + L G+ N D E TPLH AA GY +A+ L
Sbjct: 438 LDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKAL 497
Query: 154 LSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAA-KRAEEELLLHDTRC- 211
G N+ N +G+ PL A + +++ +A G D+ A K L L RC
Sbjct: 498 CEAGCNVNIKNREGETPLLTASARGYHDIVEC-LAEHGADLNACDKDGHIALHLAVRRCQ 556
Query: 212 ------WLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
L+ G + + R G + LHVA G + ++ L +A + ++ + G TPLH
Sbjct: 557 MEVIKTLLSQGCFVDYQ-DRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLH 615
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA----DEEVLSLLEELAR 313
AA+ G+ D R L G +++LT G+ DLA E V LL L +
Sbjct: 616 LAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRK 667
Score = 73.2 bits (178), Expect = 9e-13
Identities = 63/215 (29%), Positives = 95/215 (44%), Gaps = 10/215 (4%)
Query: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYL 153
+D + G +A++ A +++ ++FL E ++ D G LHVAA G+ D+A+ L
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464
Query: 154 LSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLL------- 206
S G+N + + + PL A + KA + G +V R E LL
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKA-LCEAGCNVNIKNREGETPLLTASARGY 523
Query: 207 HD-TRCWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLH 265
HD C GA A + G ALH+A + +EV++ LL G + +D G TPLH
Sbjct: 524 HDIVECLAEHGADLNA-CDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLH 582
Query: 266 AAAHWGVEDACRLLAEHGGGMDSLTHAGQRPCDLA 300
A G L E +D G+ P LA
Sbjct: 583 VACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617
Score = 67.4 bits (163), Expect = 5e-11
Identities = 57/206 (27%), Positives = 90/206 (43%), Gaps = 31/206 (15%)
Query: 94 LDSTNADGISALHQACIDENLEVVRFLVEQGAT--VNQADNEGWTPLHVAASCGYLDIAR 151
LD ++ + A+ A D+N+ ++ L+ + VNQ + G PL +AA CG + I +
Sbjct: 337 LDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQ 396
Query: 152 YLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLH-DTR 210
L+ G+ I + G + A AR G H DT
Sbjct: 397 LLIKRGSRIDVQDKGGSNAVYWA-------------ARHG---------------HVDTL 428
Query: 211 CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHW 270
+L+ P ++G ALHVAA G+ +V +LL G +P ++D + TPLH AA
Sbjct: 429 KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWH 488
Query: 271 GVEDACRLLAEHGGGMDSLTHAGQRP 296
G + L E G ++ G+ P
Sbjct: 489 GYYSVAKALCEAGCNVNIKNREGETP 514
Score = 53.5 bits (127), Expect = 7e-07
Identities = 40/122 (32%), Positives = 55/122 (45%), Gaps = 33/122 (27%)
Query: 92 AVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA---------- 141
A L++ + DG ALH A +EV++ L+ QG V+ D G TPLHVA
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVV 594
Query: 142 ----ASC-------------------GYLDIARYLLSHGANIAAVNSDGDLPLDLAESDA 178
A+C G LD+ RYL GA++ A+ +DG DLA S+
Sbjct: 595 ALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 654
Query: 179 ME 180
E
Sbjct: 655 HE 656
Score = 31.2 bits (69), Expect = 3.9
Identities = 20/54 (37%), Positives = 28/54 (51%)
Query: 90 ARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAAS 143
A LD +N G + LH A + L+VVR+L GA+V +G T +A S
Sbjct: 599 ANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARS 652
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 87.8 bits (216), Expect = 3e-17
Identities = 153/699 (21%), Positives = 256/699 (36%), Gaps = 125/699 (17%)
Query: 115 EVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLA 174
+V L ++GA+ + D+EG T H+AA+ G+++ R +++HG ++ A ++ G L LA
Sbjct: 37 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 96
Query: 175 ESDAMEGLLKAEIARRGVDVEAAKRAEEELL--LHDTRCWLNGGAMPEARHPRTGASALH 232
AK + E + L ++C P +G +ALH
Sbjct: 97 ----------------------AKNSHHECIRKLLQSKC-------PAESVDSSGKTALH 127
Query: 233 VAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHA 292
AAA+G ++ +++L + L+D DG PL A G + C L +HG ++S +
Sbjct: 128 YAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKS 187
Query: 293 GQRPCDLADEEVLS-LLEELARKQEDLR----------NQKEASQSRGQEPQAPSSSKHR 341
G+ LA E S +E L +K DL + + S++ G + S
Sbjct: 188 GRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQD 247
Query: 342 RSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSP- 400
++ + +S ER +G P ++ PPP P L+ VSSP
Sbjct: 248 ADLKTPTKPKQHDQVSKISSER----SGTP--------KKRKAPPPPISPTQLSDVSSPR 295
Query: 401 ----PHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWL 456
S K V E PF ++ R ++ GA SS
Sbjct: 296 SITSTPLSGKESVFFAEPPFKAEISSIRENKD--------RLSDSTTGADSLLDISSEAD 347
Query: 457 EGTSTQAKELRLARIT----------PTPSPKLPE-----PSVLSEVTKPPPCLENSSPP 501
+ + ++A +T SPK E S S T P L P
Sbjct: 348 QQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKP 404
Query: 502 SRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPV------RDEESESQRKARSRLMRQ 555
P+S + P+V S D R + R E SE++RK ++
Sbjct: 405 GETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQS 464
Query: 556 SRRSTQGVTLTDLKE--------AEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQ 607
R + T++ E ++ K E+ K S+ + + E+ D+ +
Sbjct: 465 RRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSH 524
Query: 608 RAEAPDGQGPGPQAAREHRKVGKE--WRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQ 665
E + E V K+ E E + R E +E R +
Sbjct: 525 FHEL--------RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE--------REK 568
Query: 666 RDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERF 725
+ P E EE + ++ + +E L E E + +LK L ++ QE
Sbjct: 569 GTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL-KSQMTQEAS 627
Query: 726 AERPALLELERFERRALERKAAELEEELKALSDLRADNQ 764
E + E A+ R EL +++ LS L + Q
Sbjct: 628 DEAEDMKE-------AMNRMIDELNKQVSELSQLYKEAQ 659
Score = 55.8 bits (133), Expect = 1e-07
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
+S ++ G +ALH A L+ V+ L E + +N D +G PL +A G+ +I +LL
Sbjct: 116 ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL 175
Query: 155 SHGANIAAVNSDGDLPLDLA----ESDAMEGLLK 184
HGA++ + N G L LA S+A+E L+K
Sbjct: 176 DHGADVNSRNKSGRTALMLACEIGSSNAVEALIK 209
Score = 39.3 bits (90), Expect = 0.014
Identities = 28/102 (27%), Positives = 53/102 (51%), Gaps = 3/102 (2%)
Query: 91 RAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIA 150
++ ++ + DG L A + + E+ FL++ GA VN + G T L +A G +
Sbjct: 145 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 204
Query: 151 RYLLSHGANIAAVNSDGDLPL---DLAESDAMEGLLKAEIAR 189
L+ GA++ V+S G L L+E+ ++ LL ++I++
Sbjct: 205 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 246
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 87.8 bits (216), Expect = 3e-17
Identities = 153/699 (21%), Positives = 256/699 (36%), Gaps = 125/699 (17%)
Query: 115 EVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLLSHGANIAAVNSDGDLPLDLA 174
+V L ++GA+ + D+EG T H+AA+ G+++ R +++HG ++ A ++ G L LA
Sbjct: 26 KVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLA 85
Query: 175 ESDAMEGLLKAEIARRGVDVEAAKRAEEELL--LHDTRCWLNGGAMPEARHPRTGASALH 232
AK + E + L ++C P +G +ALH
Sbjct: 86 ----------------------AKNSHHECIRKLLQSKC-------PAESVDSSGKTALH 116
Query: 233 VAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGMDSLTHA 292
AAA+G ++ +++L + L+D DG PL A G + C L +HG ++S +
Sbjct: 117 YAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKS 176
Query: 293 GQRPCDLADEEVLS-LLEELARKQEDLR----------NQKEASQSRGQEPQAPSSSKHR 341
G+ LA E S +E L +K DL + + S++ G + S
Sbjct: 177 GRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQD 236
Query: 342 RSSVCRLSSREKISLQDLSKERRPGGAGGPPIQDEDEGEEGPTEPPPAEPRTLNGVSSP- 400
++ + +S ER +G P ++ PPP P L+ VSSP
Sbjct: 237 ADLKTPTKPKQHDQVSKISSER----SGTP--------KKRKAPPPPISPTQLSDVSSPR 284
Query: 401 ----PHPSPKSPVQLEEAPFSRRFGLLKTGSSGALGPPERRTAEGAPGAGLQRSASSSWL 456
S K V E PF ++ R ++ GA SS
Sbjct: 285 SITSTPLSGKESVFFAEPPFKAEISSIRENKD--------RLSDSTTGADSLLDISSEAD 336
Query: 457 EGTSTQAKELRLARIT----------PTPSPKLPE-----PSVLSEVTKPPPCLENSSPP 501
+ + ++A +T SPK E S S T P L P
Sbjct: 337 QQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSL---GKP 393
Query: 502 SRIPEPESPAKPNVPTASTAPPADSRDRRRSYQMPV------RDEESESQRKARSRLMRQ 555
P+S + P+V S D R + R E SE++RK ++
Sbjct: 394 GETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQS 453
Query: 556 SRRSTQGVTLTDLKE--------AEKAAGKAPESEKPAQSLDPSRRPRVPGVENSDSPAQ 607
R + T++ E ++ K E+ K S+ + + E+ D+ +
Sbjct: 454 RRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSH 513
Query: 608 RAEAPDGQGPGPQAAREHRKVGKE--WRGPAEGEEAEPADRSQESSTLEGGPSARRQRWQ 665
E + E V K+ E E + R E +E R +
Sbjct: 514 FHEL--------RVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVE--------REK 557
Query: 666 RDLNPEPEPESEEPDGGFRTLYAELRRENERLREALTETTLRLAQLKVELERATQRQERF 725
+ P E EE + ++ + +E L E E + +LK L ++ QE
Sbjct: 558 GTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTL-KSQMTQEAS 616
Query: 726 AERPALLELERFERRALERKAAELEEELKALSDLRADNQ 764
E + E A+ R EL +++ LS L + Q
Sbjct: 617 DEAEDMKE-------AMNRMIDELNKQVSELSQLYKEAQ 648
Score = 55.8 bits (133), Expect = 1e-07
Identities = 33/94 (35%), Positives = 52/94 (55%), Gaps = 4/94 (4%)
Query: 95 DSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIARYLL 154
+S ++ G +ALH A L+ V+ L E + +N D +G PL +A G+ +I +LL
Sbjct: 105 ESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLL 164
Query: 155 SHGANIAAVNSDGDLPLDLA----ESDAMEGLLK 184
HGA++ + N G L LA S+A+E L+K
Sbjct: 165 DHGADVNSRNKSGRTALMLACEIGSSNAVEALIK 198
Score = 39.3 bits (90), Expect = 0.014
Identities = 28/102 (27%), Positives = 53/102 (51%), Gaps = 3/102 (2%)
Query: 91 RAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIA 150
++ ++ + DG L A + + E+ FL++ GA VN + G T L +A G +
Sbjct: 134 KSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAV 193
Query: 151 RYLLSHGANIAAVNSDGDLPL---DLAESDAMEGLLKAEIAR 189
L+ GA++ V+S G L L+E+ ++ LL ++I++
Sbjct: 194 EALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQ 235
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,634,454
Number of Sequences: 37866
Number of extensions: 2326433
Number of successful extensions: 26683
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 527
Number of HSP's successfully gapped in prelim test: 1758
Number of HSP's that attempted gapping in prelim test: 14369
Number of HSP's gapped (non-prelim): 10075
length of query: 782
length of database: 18,247,518
effective HSP length: 110
effective length of query: 672
effective length of database: 14,082,258
effective search space: 9463277376
effective search space used: 9463277376
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.