Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 8922735
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|8922735 elongator protein 2 [Homo sapiens]
(826 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|8922735 elongator protein 2 [Homo sapiens] 1727 0.0
gi|4757988 WD repeat domain 39 [Homo sapiens] 70 8e-12
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 60 1e-08
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 58 3e-08
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 58 3e-08
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 57 5e-08
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 57 9e-08
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 57 9e-08
gi|113865883 WD repeat domain 38 [Homo sapiens] 56 1e-07
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 56 2e-07
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 56 2e-07
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 56 2e-07
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 56 2e-07
gi|8923881 WD SOCS-box protein 2 [Homo sapiens] 55 2e-07
gi|189571685 WD repeat, sterile alpha motif and U-box domain con... 55 3e-07
gi|189571683 WD repeat, sterile alpha motif and U-box domain con... 55 3e-07
gi|189571681 WD repeat, sterile alpha motif and U-box domain con... 55 3e-07
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 53 1e-06
gi|23199987 WD repeat domain 5B [Homo sapiens] 53 1e-06
gi|26665869 WD repeat domain 51B [Homo sapiens] 53 1e-06
gi|19913367 transducin beta-like 1Y [Homo sapiens] 51 4e-06
gi|19913365 transducin beta-like 1Y [Homo sapiens] 51 4e-06
gi|15150805 transducin beta-like 1Y [Homo sapiens] 51 4e-06
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 50 1e-05
gi|16554629 WD repeat domain 5 [Homo sapiens] 50 1e-05
gi|16554627 WD repeat domain 5 [Homo sapiens] 50 1e-05
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 49 2e-05
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 49 2e-05
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 49 2e-05
gi|18874090 WD repeat domain 48 [Homo sapiens] 49 2e-05
>gi|8922735 elongator protein 2 [Homo sapiens]
Length = 826
Score = 1727 bits (4472), Expect = 0.0
Identities = 826/826 (100%), Positives = 826/826 (100%)
Query: 1 MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTAR 60
MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTAR
Sbjct: 1 MVAPVLETSHVFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTAR 60
Query: 61 VNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRR 120
VNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRR
Sbjct: 61 VNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRR 120
Query: 121 TSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILAC 180
TSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILAC
Sbjct: 121 TSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILAC 180
Query: 181 GNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYI 240
GNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYI
Sbjct: 181 GNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYI 240
Query: 241 KSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGV 300
KSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGV
Sbjct: 241 KSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGV 300
Query: 301 LQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHA 360
LQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHA
Sbjct: 301 LQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHA 360
Query: 361 FHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKR 420
FHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKR
Sbjct: 361 FHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKR 420
Query: 421 KDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQ 480
KDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQ
Sbjct: 421 KDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQ 480
Query: 481 SLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPS 540
SLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPS
Sbjct: 481 SLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPS 540
Query: 541 ILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWN 600
ILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWN
Sbjct: 541 ILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWN 600
Query: 601 TTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAF 660
TTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAF
Sbjct: 601 TTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAF 660
Query: 661 TNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVG 720
TNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVG
Sbjct: 661 TNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVG 720
Query: 721 GAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTL 780
GAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTL
Sbjct: 721 GAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTL 780
Query: 781 AIRKLCWKNCSGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL 826
AIRKLCWKNCSGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL
Sbjct: 781 AIRKLCWKNCSGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL 826
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 70.1 bits (170), Expect = 8e-12
Identities = 77/335 (22%), Positives = 126/335 (37%), Gaps = 70/335 (20%)
Query: 128 TLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNG-----FALALCLSFLPNTDVPILACGN 182
TL+ S D +R+W +G +C L+ G+ A + C ++L + C
Sbjct: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTC-- 86
Query: 183 DDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKS 242
I+ + D F+ V +L GHE+ ++ V WA G LA+CS+D + +W
Sbjct: 87 ------IWKKNQDDFECVTTLEGHENEVKSVAWAPSGN--LLATCSRDKSVWVW------ 132
Query: 243 TSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQ 302
E ++D E E V +VL H V V W P
Sbjct: 133 ---EVDEED-----------EYECV---------SVLNSHTQDVKHVVWHP--------- 160
Query: 303 QPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFH 362
L SAS D T+ L+ +E+ + V + G+ + F+ G + + +
Sbjct: 161 SQELLASASYDDTVKLYREEED-----DWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215
Query: 363 GALHLWKQNTVNPRE----------WTPEIVISG-HFDGVQDLVWDPEGEFIITVGTDQT 411
+ +W+Q + W +SG H + D+ W + T D
Sbjct: 216 RTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDA 275
Query: 412 TRLFAPWKRKDQSQVTWHEIAR-PQIHGYDLKCLA 445
R+F D Q T+ A Q H D+ C+A
Sbjct: 276 IRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVA 310
Score = 60.8 bits (146), Expect = 5e-09
Identities = 72/248 (29%), Positives = 102/248 (41%), Gaps = 53/248 (21%)
Query: 576 NSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVF---HSLTVTQMAFSPNEKFLLAV 632
N + TLLAS C ++ I +W T + V H TV ++A+SP +L +
Sbjct: 25 NPAGTLLAS-CGGDRR----IRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
Query: 633 SRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKK 692
S D T +WKK +FE V +L N++ SV W+P T SRDK
Sbjct: 80 SFDATTCIWKKN---QDDFECVTTLEGHENEVKSV--------AWAPSGNLLATCSRDKS 128
Query: 693 VVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGLECGKICLY 752
V VW E D D+ C SVL+ + T V HPSQ + + + + LY
Sbjct: 129 VWVW-EVDEEDEY------ECVSVLN---SHTQDVKHVVWHPSQELLASASYD-DTVKLY 177
Query: 753 TWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQKEAEGAEWLHFASCGE 812
E +DW C T + T+ W + Q+ ASC +
Sbjct: 178 R-------EEEDDWV-CCATLEGHESTV------WSLAFDPSGQR---------LASCSD 214
Query: 813 DHTVKIHR 820
D TV+I R
Sbjct: 215 DRTVRIWR 222
Score = 47.8 bits (112), Expect = 4e-05
Identities = 55/206 (26%), Positives = 82/206 (39%), Gaps = 35/206 (16%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGS-DNQVIHWEIEDNQLLKAVHLQGHEGP 109
V+ LN HT V + W PS EL++ S D+ V + E++ + L+GHE
Sbjct: 143 VSVLNSHTQDVKHVVW------HPSQELLASASYDDTVKLYREEEDDWVCCATLEGHEST 196
Query: 110 VYAVHAVYQRRTSDPALCTLIVSAAADSAVRLW-------------SKKGPEVMCLQTLN 156
V+++ DP+ + S + D VR+W S P C+ TL+
Sbjct: 197 VWSL-------AFDPS-GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLS 248
Query: 157 FGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLC-----GHEDWIR 211
G +++ T ACG+D R+ +D Q SL H +
Sbjct: 249 -GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVN 307
Query: 212 GVEWAAFGRDLFLASCSQDCLIRIWK 237
V W L LASCS D + WK
Sbjct: 308 CVAWNPKEPGL-LASCSDDGEVAFWK 332
Score = 38.1 bits (87), Expect = 0.034
Identities = 36/150 (24%), Positives = 60/150 (40%), Gaps = 12/150 (8%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V L H ++ V + S+ LLASA + + + W L H TV
Sbjct: 143 VSVLNSHTQDVKHVVWHPSQELLASA---SYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
Query: 620 MAFSPNEKFLLAVSRDRTWSLWK------KQDTISPEFEPVFSLFAFTNKITSVHSRIIW 673
+AF P+ + L + S DRT +W+ +Q +P + ++ HSR I+
Sbjct: 200 LAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCIC---TLSGFHSRTIY 256
Query: 674 SCDWSPDSKYFFTGSRDKKVVVWGECDSTD 703
W + T D + V+ E ++D
Sbjct: 257 DIAWCQLTGALATACGDDAIRVFQEDPNSD 286
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 59.7 bits (143), Expect = 1e-08
Identities = 76/338 (22%), Positives = 142/338 (42%), Gaps = 53/338 (15%)
Query: 78 LVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADS 137
+VS D + W+ E + L+GH V + + + L+ S +AD
Sbjct: 123 MVSASEDATIKVWDYETGDFERT--LKGHTDSVQDISFDHSGK--------LLASCSADM 172
Query: 138 AVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQF 197
++LW +G E C++T++ G+ ++ ++ +PN D + A + D I ++ Q
Sbjct: 173 TIKLWDFQGFE--CIRTMH-GHDHNVS-SVAIMPNGDHIVSA--SRDKTIKMWEVQTGYC 226
Query: 198 QKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKE 257
K + GH +W+R V G +ASCS D +R+W + K E ++ +++ ++
Sbjct: 227 VKTFT--GHREWVRMVRPNQDGT--LIASCSNDQTVRVWVVATKECKAELREHEHV-VEC 281
Query: 258 NTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMI 317
++ E+ I+ A ET +G K G LLS S DKT+
Sbjct: 282 ISWAPESSYSSISEATGSETKKSG---------------KPGPF-----LLSGSRDKTIK 321
Query: 318 LWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPRE 377
+W D +G+ L + G+ F+ G I++ A L +W +
Sbjct: 322 MW--DVSTGMCLM-----TLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMK 374
Query: 378 WTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLF 415
++ H V L + +++T DQT +++
Sbjct: 375 -----TLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 44.7 bits (104), Expect = 4e-04
Identities = 68/322 (21%), Positives = 118/322 (36%), Gaps = 58/322 (18%)
Query: 381 EIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYD 440
E + GH D VQD+ +D G+ + + D T +L+ E R +HG+D
Sbjct: 143 ERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW---------DFQGFECIRT-MHGHD 192
Query: 441 LKCLA---MINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGA 497
+ M N VS + +K ++++ + + + V NQD L
Sbjct: 193 HNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTL---- 248
Query: 498 TVPALGLSNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLW 557
SN + + + + EL E++ V I P + +
Sbjct: 249 ---IASCSNDQTVRVWVVATKECKAELR-----EHEHVV--ECISWAPESSYSSISEATG 298
Query: 558 PEVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTV 617
E +K G F ++ + KT I +W+ ++ + LV H V
Sbjct: 299 SETKKSGKPGP--FLLSGSRDKT---------------IKMWDVSTGMCLMTLVGHDNWV 341
Query: 618 TQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDW 677
+ F KF+L+ + D+T +W ++ K + H + S D+
Sbjct: 342 RGVLFHSGGKFILSCADDKTLRVWDYKN-------------KRCMKTLNAHEHFVTSLDF 388
Query: 678 SPDSKYFFTGSRDKKVVVWGEC 699
+ Y TGS D+ V VW EC
Sbjct: 389 HKTAPYVVTGSVDQTVKVW-EC 409
Score = 37.4 bits (85), Expect = 0.057
Identities = 34/129 (26%), Positives = 49/129 (37%), Gaps = 31/129 (24%)
Query: 54 LNGHTARVNCIQWI---------------CKQDGSPSTELVSGGSDNQVIHWEIEDNQLL 98
L H V CI W K+ G P L+SG D + W++ L
Sbjct: 272 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL 331
Query: 99 KAVHLQGHEGPVYAV--HAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLN 156
+ L GH+ V V H+ + I+S A D +R+W K C++TLN
Sbjct: 332 --MTLVGHDNWVRGVLFHSGGK----------FILSCADDKTLRVWDYKNKR--CMKTLN 377
Query: 157 FGNGFALAL 165
F +L
Sbjct: 378 AHEHFVTSL 386
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 58.2 bits (139), Expect = 3e-08
Identities = 109/543 (20%), Positives = 199/543 (36%), Gaps = 84/543 (15%)
Query: 177 ILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIW 236
I +CG D + +F + + K+L + HED + ++ D F+A+CS D ++IW
Sbjct: 630 IASCGADKT-LQVFKAETGE--KLLEIKAHEDEVLCCAFST--DDRFIATCSVDKKVKIW 684
Query: 237 KLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVT-------------LETVLAGHE 283
+ + T D+ + ++ FT + + +A + + GH
Sbjct: 685 NS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT 743
Query: 284 NWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLG 343
N VN + P D L L S S D T+ LW D S + + V + N
Sbjct: 744 NSVNHCRFSP----DDKL-----LASCSADGTLKLW--DATSANERKSINVKQFFLNLED 792
Query: 344 FYD--------CQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLV 395
+ C ++ DG+ I+ A + LW N + GH V ++
Sbjct: 793 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLW-----NTDSRSKVADCRGHLSWVHGVM 846
Query: 396 WDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAM--INRFQFV 453
+ P+G +T DQT RL+ K S V + ++ LA+ I R Q +
Sbjct: 847 FSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI 906
Query: 454 SGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGD 513
+G ++ + A + C L ++ E + L L N +FQ
Sbjct: 907 NGRTGQIDYLTEA-----QVSCCCLSPHLQYIAFGD-----ENGAIEILELVNNRIFQSR 956
Query: 514 IASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCV 573
+ T + Q A + ++++ + + N + L GH +
Sbjct: 957 FQHK---------KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 1007
Query: 574 TCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVS 633
+ LL+ + K +WN + + ++ V H TV S + + S
Sbjct: 1008 RLLKNSRLLSWSFDGTVK------VWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTS 1061
Query: 634 RDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKV 693
D+T +W F L +++ H+ + +S DS TG + ++
Sbjct: 1062 ADKTAKIWS------------FDLLLPLHELRG-HNGCVRCSAFSVDSTLLATGDDNGEI 1108
Query: 694 VVW 696
+W
Sbjct: 1109 RIW 1111
Score = 41.6 bits (96), Expect = 0.003
Identities = 57/261 (21%), Positives = 103/261 (39%), Gaps = 43/261 (16%)
Query: 11 VFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQ 70
V CC +S+ R + V +++ + +V + H+ +VNC +
Sbjct: 660 VLCCA--------FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT--- 708
Query: 71 DGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLI 130
+ S L +G SD + W++ + + GH V + R + D L +
Sbjct: 709 NSSHHLLLATGSSDCFLKLWDLNQKECRNTMF--GHTNSVN-----HCRFSPDDKL---L 758
Query: 131 VSAAADSAVRLWSKKGPEVMCLQTLNFGNGF-----------ALALCLSFLPNTDVPILA 179
S +AD ++LW +++N F + C S+ + ++A
Sbjct: 759 ASCSADGTLKLWDATSANER--KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVA 816
Query: 180 CGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIW--K 237
N IF D KV GH W+ GV ++ G FL S S D IR+W K
Sbjct: 817 AKNK-----IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS-FLTS-SDDQTIRLWETK 869
Query: 238 LYIKSTSLETQDDDNIRLKEN 258
K++++ + + ++ +EN
Sbjct: 870 KVCKNSAVMLKQEVDVVFQEN 890
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 58.2 bits (139), Expect = 3e-08
Identities = 109/543 (20%), Positives = 199/543 (36%), Gaps = 84/543 (15%)
Query: 177 ILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIW 236
I +CG D + +F + + K+L + HED + ++ D F+A+CS D ++IW
Sbjct: 619 IASCGADKT-LQVFKAETGE--KLLEIKAHEDEVLCCAFST--DDRFIATCSVDKKVKIW 673
Query: 237 KLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVT-------------LETVLAGHE 283
+ + T D+ + ++ FT + + +A + + GH
Sbjct: 674 NS-MTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHT 732
Query: 284 NWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLG 343
N VN + P D L L S S D T+ LW D S + + V + N
Sbjct: 733 NSVNHCRFSP----DDKL-----LASCSADGTLKLW--DATSANERKSINVKQFFLNLED 781
Query: 344 FYD--------CQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLV 395
+ C ++ DG+ I+ A + LW N + GH V ++
Sbjct: 782 PQEDMEVIVKCCSWSADGARIMVAA-KNKIFLW-----NTDSRSKVADCRGHLSWVHGVM 835
Query: 396 WDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAM--INRFQFV 453
+ P+G +T DQT RL+ K S V + ++ LA+ I R Q +
Sbjct: 836 FSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLI 895
Query: 454 SGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGD 513
+G ++ + A + C L ++ E + L L N +FQ
Sbjct: 896 NGRTGQIDYLTEA-----QVSCCCLSPHLQYIAFGD-----ENGAIEILELVNNRIFQSR 945
Query: 514 IASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCV 573
+ T + Q A + ++++ + + N + L GH +
Sbjct: 946 FQHK---------KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDF 996
Query: 574 TCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVS 633
+ LL+ + K +WN + + ++ V H TV S + + S
Sbjct: 997 RLLKNSRLLSWSFDGTVK------VWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTS 1050
Query: 634 RDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKV 693
D+T +W F L +++ H+ + +S DS TG + ++
Sbjct: 1051 ADKTAKIWS------------FDLLLPLHELRG-HNGCVRCSAFSVDSTLLATGDDNGEI 1097
Query: 694 VVW 696
+W
Sbjct: 1098 RIW 1100
Score = 41.6 bits (96), Expect = 0.003
Identities = 57/261 (21%), Positives = 103/261 (39%), Gaps = 43/261 (16%)
Query: 11 VFCCPNRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQ 70
V CC +S+ R + V +++ + +V + H+ +VNC +
Sbjct: 649 VLCCA--------FSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT--- 697
Query: 71 DGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLI 130
+ S L +G SD + W++ + + GH V + R + D L +
Sbjct: 698 NSSHHLLLATGSSDCFLKLWDLNQKECRNTMF--GHTNSVN-----HCRFSPDDKL---L 747
Query: 131 VSAAADSAVRLWSKKGPEVMCLQTLNFGNGF-----------ALALCLSFLPNTDVPILA 179
S +AD ++LW +++N F + C S+ + ++A
Sbjct: 748 ASCSADGTLKLWDATSANER--KSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVA 805
Query: 180 CGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIW--K 237
N IF D KV GH W+ GV ++ G FL S S D IR+W K
Sbjct: 806 AKNK-----IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSS-FLTS-SDDQTIRLWETK 858
Query: 238 LYIKSTSLETQDDDNIRLKEN 258
K++++ + + ++ +EN
Sbjct: 859 KVCKNSAVMLKQEVDVVFQEN 879
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 57.4 bits (137), Expect = 5e-08
Identities = 75/360 (20%), Positives = 140/360 (38%), Gaps = 52/360 (14%)
Query: 349 FNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDP-----EGEFI 403
++ DG + + +G + LW +T T ++GH + L W+P E ++
Sbjct: 164 WSPDGRKLASGCKNGQILLWDPSTGKQVGRT----LAGHSKWITGLSWEPLHANPECRYV 219
Query: 404 ITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGADEKVLRV 463
+ D + R++ + + +T H + CL S + ++ ++V
Sbjct: 220 ASSSKDGSVRIWDTTAGRCERILTGHT--------QSVTCLRWGGDGLLYSASQDRTIKV 271
Query: 464 FSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEE 523
+ A + G +N + + D L GA PA N QG + +E
Sbjct: 272 WRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSL-------QE 324
Query: 524 LLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQ------KLYGHGYEIFCVTCNS 577
L Y V Q ++D L LW + ++ GH I V +
Sbjct: 325 LKERALSRYNLVRGQGPERLVSGSDDFTL--FLWSPAEDKKPLTRMTGHQALINQVLFSP 382
Query: 578 SKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRT 637
++ASA +I LW+ + K + +L H V Q+A+S + + L++ S D T
Sbjct: 383 DSRIVASA-----SFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDST 437
Query: 638 WSLWK-KQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
+W K ++ + H+ +++ DWSPD + +G +DK + +W
Sbjct: 438 LKVWDVKAQKLAMDLPG--------------HADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 50.8 bits (120), Expect = 5e-06
Identities = 70/337 (20%), Positives = 131/337 (38%), Gaps = 75/337 (22%)
Query: 130 IVSAAADSAVRLW--SKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRI 187
+ S + D+ VR W S + P C ++ L +S+ P D LA G + +I
Sbjct: 129 LASGSGDTTVRFWDLSTETPHFTCKGHRHW------VLSISWSP--DGRKLASGCKNGQI 180
Query: 188 HIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRD---LFLASCSQDCLIRIWKL------ 238
++ + Q +L GH WI G+ W + ++AS S+D +RIW
Sbjct: 181 LLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDTTAGRCE 239
Query: 239 -----YIKSTSLETQDDDNIRLKENTFTIENESVKI--AFAVTLETVLAGHENWVNAV-- 289
+ +S + D + + ++ ++K+ A L L GH +WVN +
Sbjct: 240 RILTGHTQSVTCLRWGGDGLLYSAS----QDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295
Query: 290 ---------HWQPVFYK------DGVLQQ----------------PVRLLSASMDKTMIL 318
++P G LQ+ P RL+S S D T+ L
Sbjct: 296 STDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFL 355
Query: 319 WAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREW 378
W+P E ++ + + G+ F+ D ++ + +F ++ LW + R
Sbjct: 356 WSPAE------DKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLW-----DGRTG 404
Query: 379 TPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLF 415
+ GH V + W + +++ +D T +++
Sbjct: 405 KYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVW 441
Score = 47.0 bits (110), Expect = 7e-05
Identities = 95/452 (21%), Positives = 181/452 (40%), Gaps = 85/452 (18%)
Query: 202 SLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFT 261
SL GH + + V ++ G+ +LAS S D +R W L S ET FT
Sbjct: 109 SLEGHSEAVISVAFSPTGK--YLASGSGDTTVRFWDL-----STETPH----------FT 151
Query: 262 IENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAP 321
+ GH +WV ++ W P DG +L S + ++LW P
Sbjct: 152 CK-----------------GHRHWVLSISWSP----DGR-----KLASGCKNGQILLWDP 185
Query: 322 DEESGVWLEQVRVGEVGGNT-LGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTP 380
+G + + G T L + N + + + + G++ +W +T R
Sbjct: 186 S--TGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW--DTTAGR---C 238
Query: 381 EIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARP-QIHGY 439
E +++GH V L W +G + + D+T ++ W+ D + R Q HG+
Sbjct: 239 ERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKV---WRAHDGV------LCRTLQGHGH 288
Query: 440 DLKCLAMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATV 499
+ +A+ + +GA E + P++ + + ++L+ +L G
Sbjct: 289 WVNTMALSTDYALRTGAFEPAEASVN-PQDLQGSLQELKERALSRY------NLVRGQGP 341
Query: 500 PALGLSNKAVFQGDIASQPSDEEELLTSTGFE--YQQVAFQP-SILTEPPTEDHLLQNTL 556
L +S F + S D++ L TG + QV F P S + + D ++ L
Sbjct: 342 ERL-VSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK--L 398
Query: 557 WPE-----VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLV 611
W + L GH ++ + ++ LL S + + +W+ + K +L
Sbjct: 399 WDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSG-----SSDSTLKVWDVKAQKLAMDLP 453
Query: 612 FHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKK 643
H+ V + +SP+ + + + +D+ +W++
Sbjct: 454 GHADEVYAVDWSPDGQRVASGGKDKCLRIWRR 485
Score = 40.8 bits (94), Expect = 0.005
Identities = 66/298 (22%), Positives = 104/298 (34%), Gaps = 88/298 (29%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAV 113
L GHT V C++W DG L S D + W D L + + GH A+
Sbjct: 242 LTGHTQSVTCLRW--GGDGL----LYSASQDRTIKVWRAHDGVLCRTLQGHGHWVNTMAL 295
Query: 114 HAVYQRRTS--DPALCTL------------------------------IVSAAADSAVRL 141
Y RT +PA ++ +VS + D + L
Sbjct: 296 STDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFL 355
Query: 142 WSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVL 201
WS + + L G AL L + D I+A + D I ++ + ++ +
Sbjct: 356 WSPAEDK----KPLTRMTGHQ-ALINQVLFSPDSRIVASASFDKSIKLWDGRTGKY--LA 408
Query: 202 SLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFT 261
SL GH + + W+A R L S S D +++W + + +++
Sbjct: 409 SLRGHVAAVYQIAWSADSR--LLVSGSSDSTLKVWDVKAQKLAMD--------------- 451
Query: 262 IENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILW 319
L GH + V AV W P DG R+ S DK + +W
Sbjct: 452 -----------------LPGHADEVYAVDWSP----DG-----QRVASGGKDKCLRIW 483
Score = 40.4 bits (93), Expect = 0.007
Identities = 38/136 (27%), Positives = 66/136 (48%), Gaps = 23/136 (16%)
Query: 16 NRVRGVLNWSSGPRGLLAFGTSCSVVLYDPLK-RVVVTNLNGHTARVNCIQWICKQDGSP 74
N VRG GP L++ ++ L+ P + + +T + GH A +N + + SP
Sbjct: 334 NLVRG-----QGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLF------SP 382
Query: 75 STELVSGGS-DNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSA 133
+ +V+ S D + W+ + L + L+GH V AVYQ S A L+VS
Sbjct: 383 DSRIVASASFDKSIKLWDGRTGKYLAS--LRGH------VAAVYQIAWS--ADSRLLVSG 432
Query: 134 AADSAVRLWSKKGPEV 149
++DS +++W K ++
Sbjct: 433 SSDSTLKVWDVKAQKL 448
Score = 39.7 bits (91), Expect = 0.012
Identities = 24/84 (28%), Positives = 37/84 (44%), Gaps = 13/84 (15%)
Query: 613 HSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRII 672
HS V +AFSP K+L + S D T W T +P F H +
Sbjct: 113 HSEAVISVAFSPTGKYLASGSGDTTVRFW-DLSTETPHF------------TCKGHRHWV 159
Query: 673 WSCDWSPDSKYFFTGSRDKKVVVW 696
S WSPD + +G ++ ++++W
Sbjct: 160 LSISWSPDGRKLASGCKNGQILLW 183
Score = 38.9 bits (89), Expect = 0.020
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 21/167 (12%)
Query: 72 GSPSTELVSGGSDNQVIHWE-IEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLI 130
G LVSG D + W ED + L + GH+ + V R ++
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPL--TRMTGHQALINQVLFSPDSR--------IV 387
Query: 131 VSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIF 190
SA+ D +++LW + + + + + +A + D +L G+ D + ++
Sbjct: 388 ASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAW------SADSRLLVSGSSDSTLKVW 441
Query: 191 AQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWK 237
+ + + L GH D + V+W+ G+ +AS +D +RIW+
Sbjct: 442 DVKAQKL--AMDLPGHADEVYAVDWSPDGQR--VASGGKDKCLRIWR 484
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 56.6 bits (135), Expect = 9e-08
Identities = 120/651 (18%), Positives = 234/651 (35%), Gaps = 104/651 (15%)
Query: 51 VTNLNGHTAR--VNCIQWIC-KQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHE 107
+TNL+ R + + C +DG + S G+D + ++ E + K + ++ HE
Sbjct: 603 ITNLSRLVVRPHTDAVYHACFSEDGQ---RIASCGADKTLQVFKAETGE--KLLEIKAHE 657
Query: 108 GPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCL 167
V R I + + D V++W+ E++ + C
Sbjct: 658 DEVLCCAFSTDDR--------FIATCSVDKKVKIWNSMTGELVH----TYDEHSEQVNCC 705
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASC 227
F ++ +LA G+ DC + ++ + + ++ GH + + ++ D LASC
Sbjct: 706 HFTNSSHHLLLATGSSDCFLKLWDLNQKECRN--TMFGHTNSVNHCRFSP--DDKLLASC 761
Query: 228 SQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVN 287
S D +++W +TS + N++ F + LE E V
Sbjct: 762 SADGTLKLWD----ATSANERKSINVK---------------QFFLNLEDPQEDMEVIVK 802
Query: 288 AVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDC 347
W DG R++ A+ +K + D + L ++ G +T+ + C
Sbjct: 803 CCSWSA----DGA-----RIMVAAKNKIFLF---DIHTSGLLGEIHTGH--HSTIQY--C 846
Query: 348 QFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVG 407
F+ + + + LW N + GH V +++ P+G +T
Sbjct: 847 DFSPQNHLAVVALSQYCVELW-----NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 901
Query: 408 TDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAM--INRFQFVSGADEKVLRVFS 465
DQT RL+ K S V + ++ LA+ I R Q ++G ++ +
Sbjct: 902 DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 961
Query: 466 APRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELL 525
A + C L ++ E + L L N +FQ +
Sbjct: 962 A-----QVSCCCLSPHLQYIAFGD-----ENGAIEILELVNNRIFQSRFQHK-------- 1003
Query: 526 TSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASA 585
T + Q A + ++++ + + N + L GH + + LL+ +
Sbjct: 1004 -KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWS 1062
Query: 586 CKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQD 645
K +WN + + ++ V H TV S + + S D+T +W
Sbjct: 1063 FDGTVK------VWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS--- 1113
Query: 646 TISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
F L +++ H+ + +S DS TG + ++ +W
Sbjct: 1114 ---------FDLLLPLHELRG-HNGCVRCSAFSVDSTLLATGDDNGEIRIW 1154
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 56.6 bits (135), Expect = 9e-08
Identities = 120/651 (18%), Positives = 234/651 (35%), Gaps = 104/651 (15%)
Query: 51 VTNLNGHTAR--VNCIQWIC-KQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHE 107
+TNL+ R + + C +DG + S G+D + ++ E + K + ++ HE
Sbjct: 592 ITNLSRLVVRPHTDAVYHACFSEDGQ---RIASCGADKTLQVFKAETGE--KLLEIKAHE 646
Query: 108 GPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCL 167
V R I + + D V++W+ E++ + C
Sbjct: 647 DEVLCCAFSTDDR--------FIATCSVDKKVKIWNSMTGELVH----TYDEHSEQVNCC 694
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASC 227
F ++ +LA G+ DC + ++ + + ++ GH + + ++ D LASC
Sbjct: 695 HFTNSSHHLLLATGSSDCFLKLWDLNQKECRN--TMFGHTNSVNHCRFSP--DDKLLASC 750
Query: 228 SQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVN 287
S D +++W +TS + N++ F + LE E V
Sbjct: 751 SADGTLKLWD----ATSANERKSINVK---------------QFFLNLEDPQEDMEVIVK 791
Query: 288 AVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDC 347
W DG R++ A+ +K + D + L ++ G +T+ + C
Sbjct: 792 CCSWSA----DGA-----RIMVAAKNKIFLF---DIHTSGLLGEIHTGH--HSTIQY--C 835
Query: 348 QFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVG 407
F+ + + + LW N + GH V +++ P+G +T
Sbjct: 836 DFSPQNHLAVVALSQYCVELW-----NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 890
Query: 408 TDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAM--INRFQFVSGADEKVLRVFS 465
DQT RL+ K S V + ++ LA+ I R Q ++G ++ +
Sbjct: 891 DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 950
Query: 466 APRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIASQPSDEEELL 525
A + C L ++ E + L L N +FQ +
Sbjct: 951 A-----QVSCCCLSPHLQYIAFGD-----ENGAIEILELVNNRIFQSRFQHK-------- 992
Query: 526 TSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLYGHGYEIFCVTCNSSKTLLASA 585
T + Q A + ++++ + + N + L GH + + LL+ +
Sbjct: 993 -KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWS 1051
Query: 586 CKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQD 645
K +WN + + ++ V H TV S + + S D+T +W
Sbjct: 1052 FDGTVK------VWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS--- 1102
Query: 646 TISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
F L +++ H+ + +S DS TG + ++ +W
Sbjct: 1103 ---------FDLLLPLHELRG-HNGCVRCSAFSVDSTLLATGDDNGEIRIW 1143
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 56.2 bits (134), Expect = 1e-07
Identities = 81/336 (24%), Positives = 131/336 (38%), Gaps = 71/336 (21%)
Query: 78 LVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADS 137
L++G D V WE QLL L GH GPV + R + D L SA+ D
Sbjct: 36 LLTGSEDGCVYGWETRSGQLL--WRLGGHTGPV-----KFCRFSPDG---HLFASASCDC 85
Query: 138 AVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQF 197
VRLW CL+ L G+ ++ +SF P D LA G D R+ ++ Q+ Q
Sbjct: 86 TVRLWDV--ARAKCLRVLK-GHQRSVE-TVSFSP--DSRQLASGGWDKRVMLWDVQSGQM 139
Query: 198 QKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKE 257
++ L GH D I+ +++ LA+ S D + IW L + + ++ Q
Sbjct: 140 LRL--LVGHRDSIQSSDFSPTVN--CLATGSWDSTVHIWDLRMVTPAVSHQ--------- 186
Query: 258 NTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMI 317
L GH ++ + + G+ L S S DKT+
Sbjct: 187 --------------------ALEGHSANISCL----CYSASGL------LASGSWDKTIH 216
Query: 318 LWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPRE 377
+W P S + ++ G+ F+ D + + + + +W NT E
Sbjct: 217 IWKPTTSS-------LLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 269
Query: 378 WTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTR 413
+ G D + P+G+ +++ DQT R
Sbjct: 270 -----TLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 56.2 bits (134), Expect = 1e-07
Identities = 53/202 (26%), Positives = 89/202 (44%), Gaps = 29/202 (14%)
Query: 38 CSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSP-STELVSGGSDNQVIHWEIEDNQ 96
C+V L+D + + L GH V + + SP S +L SGG D +V+ W+++ Q
Sbjct: 85 CTVRLWDVARAKCLRVLKGHQRSVETVSF------SPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 97 LLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWS-KKGPEVMCLQTL 155
+L+ L GH + Q P + + + + DS V +W + + Q L
Sbjct: 139 MLRL--LVGHRDSI-------QSSDFSPTV-NCLATGSWDSTVHIWDLRMVTPAVSHQAL 188
Query: 156 NFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEW 215
+ LC S +LA G+ D IHI+ ++ L GH W++ +
Sbjct: 189 EGHSANISCLCYS-----ASGLLASGSWDKTIHIWKPTTSSL--LIQLKGHVTWVKSI-- 239
Query: 216 AAFGRD-LFLASCSQDCLIRIW 236
AF D L+LAS ++++W
Sbjct: 240 -AFSPDELWLASAGYSRMVKVW 260
Score = 38.5 bits (88), Expect = 0.026
Identities = 35/136 (25%), Positives = 53/136 (38%), Gaps = 19/136 (13%)
Query: 562 KLYG-HGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQM 620
K +G HG E+ NSS E + W T S + + L H+ V
Sbjct: 15 KFFGQHGGEV-----NSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC 69
Query: 621 AFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPD 680
FSP+ + S D T LW A ++ H R + + +SPD
Sbjct: 70 RFSPDGHLFASASCDCTVRLWDVAR-------------AKCLRVLKGHQRSVETVSFSPD 116
Query: 681 SKYFFTGSRDKKVVVW 696
S+ +G DK+V++W
Sbjct: 117 SRQLASGGWDKRVMLW 132
Score = 37.0 bits (84), Expect = 0.075
Identities = 34/136 (25%), Positives = 54/136 (39%), Gaps = 29/136 (21%)
Query: 561 QKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQM 620
Q L GH I C+ C S+ LLAS I +W T+ + L H V +
Sbjct: 186 QALEGHSANISCL-CYSASGLLASG-----SWDKTIHIWKPTTSSLLIQLKGHVTWVKSI 239
Query: 621 AFSPNEKFLLAVSRDRTWSLW-----KKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSC 675
AFSP+E +L + R +W K +T+ + + +C
Sbjct: 240 AFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLD------------------VAHTC 281
Query: 676 DWSPDSKYFFTGSRDK 691
++PD K +G+ D+
Sbjct: 282 AFTPDGKILVSGAADQ 297
Score = 34.3 bits (77), Expect = 0.49
Identities = 33/136 (24%), Positives = 52/136 (38%), Gaps = 20/136 (14%)
Query: 562 KLYGH-GYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQM 620
+L GH G FC +++C + LW+ K ++ L H +V +
Sbjct: 58 RLGGHTGPVKFCRFSPDGHLFASASCDCTVR------LWDVARAKCLRVLKGHQRSVETV 111
Query: 621 AFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPD 680
+FSP+ + L + D+ LW Q ++ H I S D+SP
Sbjct: 112 SFSPDSRQLASGGWDKRVMLWDVQS-------------GQMLRLLVGHRDSIQSSDFSPT 158
Query: 681 SKYFFTGSRDKKVVVW 696
TGS D V +W
Sbjct: 159 VNCLATGSWDSTVHIW 174
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/101 (26%), Positives = 45/101 (44%), Gaps = 11/101 (10%)
Query: 596 IILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVF 655
++LW+ S + ++ LV H ++ FSP L S D T +W + ++P
Sbjct: 129 VMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR-MVTP------ 181
Query: 656 SLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
A +++ HS I SC S +GS DK + +W
Sbjct: 182 ---AVSHQALEGHSANI-SCLCYSASGLLASGSWDKTIHIW 218
Score = 30.8 bits (68), Expect = 5.4
Identities = 33/152 (21%), Positives = 56/152 (36%), Gaps = 21/152 (13%)
Query: 264 NESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDE 323
N V AV H VN+ + P DG + LL+ S D + W
Sbjct: 2 NSGVPATLAVRRVKFFGQHGGEVNSSAFSP----DGQM-----LLTGSEDGCVYGWETRS 52
Query: 324 ESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIV 383
+W +GG+T C+F+ DG + + + + LW V
Sbjct: 53 GQLLW-------RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLR-----V 100
Query: 384 ISGHFDGVQDLVWDPEGEFIITVGTDQTTRLF 415
+ GH V+ + + P+ + + G D+ L+
Sbjct: 101 LKGHQRSVETVSFSPDSRQLASGGWDKRVMLW 132
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/299 (24%), Positives = 110/299 (36%), Gaps = 61/299 (20%)
Query: 76 TELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAA 135
T L +G D W ED L A L H+GP++A+ + R+ + I+SA
Sbjct: 250 TLLATGSYDGFARIWT-EDGNL--ASTLGQHKGPIFALK--WNRKGN------YILSAGV 298
Query: 136 DSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQND 195
D +W E Q F + A AL + + NT +C D C IH+ D
Sbjct: 299 DKTTIIWDAHTGEAK--QQFPFHS--APALDVDWQNNTT--FASCSTDMC-IHVCRLGCD 351
Query: 196 QFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRL 255
+ K GH + + ++W G + LASCS D ++IW S E D
Sbjct: 352 RPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIW-----SMKQEVCIHD---- 398
Query: 256 KENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKT 315
L H + + W P + L SAS D T
Sbjct: 399 -----------------------LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST 435
Query: 316 MILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVN 374
+ LW D E GV + + Y F+ DG + + +F +H+W + N
Sbjct: 436 VRLW--DIERGVCTHTLTKHQE-----PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/147 (28%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVHLQGHEGP 109
V GHT VN I+W PS L++ SD+ + W ++ + LQ H
Sbjct: 354 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQEVCIH--DLQAHNKE 405
Query: 110 VYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWS-KKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW ++G +C TL ++
Sbjct: 406 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG---VCTHTLTKHQEPVYSVAF 462
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 463 S----PDGKYLASGSFDKCVHIWNTQS 485
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/160 (22%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 175 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 225
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N +G+++ ++ G +W + + + H
Sbjct: 226 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE------DGNLASTLGQHKG 279
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G +I++ G D+TT ++ + + Q +H
Sbjct: 280 PIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFH 319
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ + +L H+ +
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ +T H
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC------------THTLTK-HQE 455
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 456 PVYSVAFSPDGKYLASGSFDKCVHIW 481
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/299 (24%), Positives = 110/299 (36%), Gaps = 61/299 (20%)
Query: 76 TELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAA 135
T L +G D W ED L A L H+GP++A+ + R+ + I+SA
Sbjct: 250 TLLATGSYDGFARIWT-EDGNL--ASTLGQHKGPIFALK--WNRKGN------YILSAGV 298
Query: 136 DSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQND 195
D +W E Q F + A AL + + NT +C D C IH+ D
Sbjct: 299 DKTTIIWDAHTGEAK--QQFPFHS--APALDVDWQNNTT--FASCSTDMC-IHVCRLGCD 351
Query: 196 QFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRL 255
+ K GH + + ++W G + LASCS D ++IW S E D
Sbjct: 352 RPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIW-----SMKQEVCIHD---- 398
Query: 256 KENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKT 315
L H + + W P + L SAS D T
Sbjct: 399 -----------------------LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST 435
Query: 316 MILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVN 374
+ LW D E GV + + Y F+ DG + + +F +H+W + N
Sbjct: 436 VRLW--DIERGVCTHTLTKHQE-----PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 487
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/147 (28%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVHLQGHEGP 109
V GHT VN I+W PS L++ SD+ + W ++ + LQ H
Sbjct: 354 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQEVCIH--DLQAHNKE 405
Query: 110 VYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWS-KKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW ++G +C TL ++
Sbjct: 406 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG---VCTHTLTKHQEPVYSVAF 462
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 463 S----PDGKYLASGSFDKCVHIWNTQS 485
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/160 (22%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 175 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 225
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N +G+++ ++ G +W + + + H
Sbjct: 226 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE------DGNLASTLGQHKG 279
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G +I++ G D+TT ++ + + Q +H
Sbjct: 280 PIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFH 319
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ + +L H+ +
Sbjct: 354 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQEVCIHDLQAHNKEIYT 408
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ +T H
Sbjct: 409 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC------------THTLTK-HQE 455
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 456 PVYSVAFSPDGKYLASGSFDKCVHIW 481
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/299 (24%), Positives = 110/299 (36%), Gaps = 61/299 (20%)
Query: 76 TELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAA 135
T L +G D W ED L A L H+GP++A+ + R+ + I+SA
Sbjct: 301 TLLATGSYDGFARIWT-EDGNL--ASTLGQHKGPIFALK--WNRKGN------YILSAGV 349
Query: 136 DSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQND 195
D +W E Q F + A AL + + NT +C D C IH+ D
Sbjct: 350 DKTTIIWDAHTGEAK--QQFPFHS--APALDVDWQNNTT--FASCSTDMC-IHVCRLGCD 402
Query: 196 QFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRL 255
+ K GH + + ++W G + LASCS D ++IW S E D
Sbjct: 403 RPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIW-----SMKQEVCIHD---- 449
Query: 256 KENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKT 315
L H + + W P + L SAS D T
Sbjct: 450 -----------------------LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST 486
Query: 316 MILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVN 374
+ LW D E GV + + Y F+ DG + + +F +H+W + N
Sbjct: 487 VRLW--DIERGVCTHTLTKHQE-----PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/147 (28%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVHLQGHEGP 109
V GHT VN I+W PS L++ SD+ + W ++ + LQ H
Sbjct: 405 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQEVCIH--DLQAHNKE 456
Query: 110 VYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWS-KKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW ++G +C TL ++
Sbjct: 457 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG---VCTHTLTKHQEPVYSVAF 513
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 514 S----PDGKYLASGSFDKCVHIWNTQS 536
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/160 (22%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 226 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 276
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N +G+++ ++ G +W + + + H
Sbjct: 277 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE------DGNLASTLGQHKG 330
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G +I++ G D+TT ++ + + Q +H
Sbjct: 331 PIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFH 370
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ + +L H+ +
Sbjct: 405 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ +T H
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC------------THTLTK-HQE 506
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 507 PVYSVAFSPDGKYLASGSFDKCVHIW 532
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/299 (24%), Positives = 110/299 (36%), Gaps = 61/299 (20%)
Query: 76 TELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAA 135
T L +G D W ED L A L H+GP++A+ + R+ + I+SA
Sbjct: 301 TLLATGSYDGFARIWT-EDGNL--ASTLGQHKGPIFALK--WNRKGN------YILSAGV 349
Query: 136 DSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQND 195
D +W E Q F + A AL + + NT +C D C IH+ D
Sbjct: 350 DKTTIIWDAHTGEAK--QQFPFHS--APALDVDWQNNTT--FASCSTDMC-IHVCRLGCD 402
Query: 196 QFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRL 255
+ K GH + + ++W G + LASCS D ++IW S E D
Sbjct: 403 RPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIW-----SMKQEVCIHD---- 449
Query: 256 KENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKT 315
L H + + W P + L SAS D T
Sbjct: 450 -----------------------LQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDST 486
Query: 316 MILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVN 374
+ LW D E GV + + Y F+ DG + + +F +H+W + N
Sbjct: 487 VRLW--DIERGVCTHTLTKHQE-----PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGN 538
Score = 45.4 bits (106), Expect = 2e-04
Identities = 42/147 (28%), Positives = 66/147 (44%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVHLQGHEGP 109
V GHT VN I+W PS L++ SD+ + W ++ + LQ H
Sbjct: 405 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQEVCIH--DLQAHNKE 456
Query: 110 VYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWS-KKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW ++G +C TL ++
Sbjct: 457 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG---VCTHTLTKHQEPVYSVAF 513
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 514 S----PDGKYLASGSFDKCVHIWNTQS 536
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/160 (22%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 226 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 276
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N +G+++ ++ G +W + + + H
Sbjct: 277 CIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTE------DGNLASTLGQHKG 330
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G +I++ G D+TT ++ + + Q +H
Sbjct: 331 PIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFH 370
Score = 40.8 bits (94), Expect = 0.005
Identities = 37/146 (25%), Positives = 61/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ + +L H+ +
Sbjct: 405 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQEVCIHDLQAHNKEIYT 459
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ +T H
Sbjct: 460 IKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC------------THTLTK-HQE 506
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 507 PVYSVAFSPDGKYLASGSFDKCVHIW 532
>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
Length = 404
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/254 (20%), Positives = 104/254 (40%), Gaps = 57/254 (22%)
Query: 170 LPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQ 229
+P+ +LA G +D +I I+ Q +L+L GH+D +R + + G L L S S+
Sbjct: 118 VPDVSCLVLATGLNDGQIKIWEVQTGLL--LLNLSGHQDVVRDLSFTPSG-SLILVSASR 174
Query: 230 DCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAV 289
D +RIW L ++ VL+GH WV
Sbjct: 175 DKTLRIWDLNKHGKQIQ-------------------------------VLSGHLQWV--- 200
Query: 290 HWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQF 349
Y + L SA+ +K++ LW+ + ++ G+ C F
Sbjct: 201 ------YCCSISPDCSMLCSAAGEKSVFLWS-------MRSYTLIRKLEGHQSSVVSCDF 247
Query: 350 NEDGSMIIAHAFHGALHLW------KQNTVNPREWTPEIVISG-HFDGVQDLVWDPEGEF 402
+ D ++++ ++ + +W + +++ + P + S H ++ + + PEG +
Sbjct: 248 SPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDVHISSLRSVCFSPEGLY 307
Query: 403 IITVGTDQTTRLFA 416
+ TV D+ R++A
Sbjct: 308 LATVADDRLLRIWA 321
Score = 44.7 bits (104), Expect = 4e-04
Identities = 33/144 (22%), Positives = 64/144 (44%), Gaps = 18/144 (12%)
Query: 559 EVQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVT 618
++Q L GH ++C + + ++L SA A +K ++ LW+ S+ ++ L H +V
Sbjct: 189 QIQVLSGHLQWVYCCSISPDCSMLCSA--AGEK---SVFLWSMRSYTLIRKLEGHQSSVV 243
Query: 619 QMAFSPNEKFLLAVSRDRTWSLW------KKQDTISPEFEPVFSLFAFTNKITSVHSRII 672
FSP+ L+ S D +W + + + +P + VH +
Sbjct: 244 SCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMD-------DSDVHISSL 296
Query: 673 WSCDWSPDSKYFFTGSRDKKVVVW 696
S +SP+ Y T + D+ + +W
Sbjct: 297 RSVCFSPEGLYLATVADDRLLRIW 320
Score = 42.4 bits (98), Expect = 0.002
Identities = 33/140 (23%), Positives = 63/140 (45%), Gaps = 19/140 (13%)
Query: 279 LAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVG 338
L+GH++ V + + P + L+SAS DKT+ +W ++ +Q++V +
Sbjct: 149 LSGHQDVVRDLSFTP--------SGSLILVSASRDKTLRIWDLNKHG----KQIQV--LS 194
Query: 339 GNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDP 398
G+ Y C + D SM+ + A ++ LW R +T + GH V + P
Sbjct: 195 GHLQWVYCCSISPDCSMLCSAAGEKSVFLWSM-----RSYTLIRKLEGHQSSVVSCDFSP 249
Query: 399 EGEFIITVGTDQTTRLFAPW 418
+ ++T D ++ P+
Sbjct: 250 DSALLVTASYDTNVIMWDPY 269
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/132 (24%), Positives = 57/132 (43%), Gaps = 31/132 (23%)
Query: 596 IILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLL-AVSRDRTWSLW------KKQDTIS 648
I +W + + NL H V ++F+P+ +L + SRD+T +W K+ +S
Sbjct: 135 IKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLS 194
Query: 649 PEFEPVF------------------SLFAFTNKITSV------HSRIIWSCDWSPDSKYF 684
+ V+ S+F ++ + ++ H + SCD+SPDS
Sbjct: 195 GHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALL 254
Query: 685 FTGSRDKKVVVW 696
T S D V++W
Sbjct: 255 VTASYDTNVIMW 266
Score = 38.9 bits (89), Expect = 0.020
Identities = 36/164 (21%), Positives = 68/164 (41%), Gaps = 22/164 (13%)
Query: 78 LVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADS 137
L +G +D Q+ WE++ LL ++L GH+ V + + P+ ++VSA+ D
Sbjct: 126 LATGLNDGQIKIWEVQTGLLL--LNLSGHQD-------VVRDLSFTPSGSLILVSASRDK 176
Query: 138 AVRLW--SKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQND 195
+R+W +K G ++ L C S P+ + A G +F
Sbjct: 177 TLRIWDLNKHGKQIQVL-----SGHLQWVYCCSISPDCSMLCSAAGEKS----VFLWSMR 227
Query: 196 QFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLY 239
+ + L GH+ + +++ L + S D + +W Y
Sbjct: 228 SYTLIRKLEGHQSSVVSCDFSP--DSALLVTASYDTNVIMWDPY 269
Score = 32.3 bits (72), Expect = 1.8
Identities = 33/149 (22%), Positives = 58/149 (38%), Gaps = 32/149 (21%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVF------- 612
++KL GH + V+C+ S SA +I+W+ + +++++L
Sbjct: 232 IRKLEGHQSSV--VSCDFSPD---SALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAM 286
Query: 613 -----HSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSV 667
H ++ + FSP +L V+ DR +W + F P+ TN +
Sbjct: 287 DDSDVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPM------TNGL--- 337
Query: 668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
C + P TG+RD V W
Sbjct: 338 ------CCTFFPHGGVIATGTRDGHVQFW 360
>gi|189571685 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/264 (25%), Positives = 110/264 (41%), Gaps = 57/264 (21%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQN--LVFHSLTV 617
+ L HG ++ C C S +LLA+ C K I L++ + ++ + L FH+ V
Sbjct: 5 IHTLADHGDDVNC--CAFSFSLLAT-CSLDK----TIRLYSLRDFTELPHSPLKFHTYAV 57
Query: 618 TQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDW 677
FSP+ L + S D T LW ++ + A + + R+ C +
Sbjct: 58 HCCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSPVRV---CQF 105
Query: 678 SPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQR 737
SPDS +G+ D VV+W + + + C SV D A A S P+
Sbjct: 106 SPDSTCLASGAADGTVVLW-------NAQSYKLYRCGSVKDGSLAACAFS------PNGS 152
Query: 738 YVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQK 797
+ V G CG + ++ +D C+ + ++H L I C + Q
Sbjct: 153 FFV-TGSSCGDLTVW-----------DDKMRCLHS--EKAHDLGI------TCCDFSSQP 192
Query: 798 EAEGAEWLHF---ASCGEDHTVKI 818
++G + L F ASCG+D VKI
Sbjct: 193 VSDGEQGLQFFRLASCGQDCQVKI 216
Score = 40.0 bits (92), Expect = 0.009
Identities = 69/281 (24%), Positives = 115/281 (40%), Gaps = 67/281 (23%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTE-LVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYA 112
L HT V+C + SPS L S +D + W E+ Q+L AV Q PV
Sbjct: 50 LKFHTYAVHCCCF------SPSGHILASCSTDGTTVLWNTENGQML-AVMEQPSGSPVRV 102
Query: 113 VHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPN 172
+ S + C + S AAD V LW+ + ++ ++ G+ LA C +F PN
Sbjct: 103 C------QFSPDSTC--LASGAADGTVVLWNAQSYKLYRCGSVKDGS---LAAC-AFSPN 150
Query: 173 TDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAF-------GRDLF-L 224
+ D + +D+ + + S H+ I ++++ G F L
Sbjct: 151 GSFFVTGSSCGDLTVW-----DDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRL 205
Query: 225 ASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHEN 284
ASC QDC ++IW I + + + F + ++ L+GH
Sbjct: 206 ASCGQDCQVKIW-------------------------IVSFTHILGFELKYKSTLSGHCA 240
Query: 285 WVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEES 325
V A F DG + L+S S+DK++I++ + E+
Sbjct: 241 PVLAC----AFSHDGQM-----LVSGSVDKSVIVYDTNTEN 272
Score = 33.9 bits (76), Expect = 0.63
Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 12/101 (11%)
Query: 595 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPV 654
++I+++T + + L H+ VT AF+PN L S D+T ++W+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ------------ 309
Query: 655 FSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVV 695
F L + H ++ DWS + + ++D K +V
Sbjct: 310 FDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLV 350
Score = 30.4 bits (67), Expect = 7.0
Identities = 11/29 (37%), Positives = 19/29 (65%)
Query: 668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
H+R + +C ++P++ TGS DK V +W
Sbjct: 280 HTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
>gi|189571683 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/264 (25%), Positives = 110/264 (41%), Gaps = 57/264 (21%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQN--LVFHSLTV 617
+ L HG ++ C C S +LLA+ C K I L++ + ++ + L FH+ V
Sbjct: 5 IHTLADHGDDVNC--CAFSFSLLAT-CSLDK----TIRLYSLRDFTELPHSPLKFHTYAV 57
Query: 618 TQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDW 677
FSP+ L + S D T LW ++ + A + + R+ C +
Sbjct: 58 HCCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSPVRV---CQF 105
Query: 678 SPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQR 737
SPDS +G+ D VV+W + + + C SV D A A S P+
Sbjct: 106 SPDSTCLASGAADGTVVLW-------NAQSYKLYRCGSVKDGSLAACAFS------PNGS 152
Query: 738 YVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQK 797
+ V G CG + ++ +D C+ + ++H L I C + Q
Sbjct: 153 FFV-TGSSCGDLTVW-----------DDKMRCLHS--EKAHDLGI------TCCDFSSQP 192
Query: 798 EAEGAEWLHF---ASCGEDHTVKI 818
++G + L F ASCG+D VKI
Sbjct: 193 VSDGEQGLQFFRLASCGQDCQVKI 216
Score = 40.0 bits (92), Expect = 0.009
Identities = 69/281 (24%), Positives = 115/281 (40%), Gaps = 67/281 (23%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTE-LVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYA 112
L HT V+C + SPS L S +D + W E+ Q+L AV Q PV
Sbjct: 50 LKFHTYAVHCCCF------SPSGHILASCSTDGTTVLWNTENGQML-AVMEQPSGSPVRV 102
Query: 113 VHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPN 172
+ S + C + S AAD V LW+ + ++ ++ G+ LA C +F PN
Sbjct: 103 C------QFSPDSTC--LASGAADGTVVLWNAQSYKLYRCGSVKDGS---LAAC-AFSPN 150
Query: 173 TDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAF-------GRDLF-L 224
+ D + +D+ + + S H+ I ++++ G F L
Sbjct: 151 GSFFVTGSSCGDLTVW-----DDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRL 205
Query: 225 ASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHEN 284
ASC QDC ++IW I + + + F + ++ L+GH
Sbjct: 206 ASCGQDCQVKIW-------------------------IVSFTHILGFELKYKSTLSGHCA 240
Query: 285 WVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEES 325
V A F DG + L+S S+DK++I++ + E+
Sbjct: 241 PVLAC----AFSHDGQM-----LVSGSVDKSVIVYDTNTEN 272
Score = 33.9 bits (76), Expect = 0.63
Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 12/101 (11%)
Query: 595 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPV 654
++I+++T + + L H+ VT AF+PN L S D+T ++W+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ------------ 309
Query: 655 FSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVV 695
F L + H ++ DWS + + ++D K +V
Sbjct: 310 FDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLV 350
Score = 30.4 bits (67), Expect = 7.0
Identities = 11/29 (37%), Positives = 19/29 (65%)
Query: 668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
H+R + +C ++P++ TGS DK V +W
Sbjct: 280 HTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
>gi|189571681 WD repeat, sterile alpha motif and U-box domain
containing 1 [Homo sapiens]
Length = 476
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/264 (25%), Positives = 110/264 (41%), Gaps = 57/264 (21%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQN--LVFHSLTV 617
+ L HG ++ C C S +LLA+ C K I L++ + ++ + L FH+ V
Sbjct: 5 IHTLADHGDDVNC--CAFSFSLLAT-CSLDK----TIRLYSLRDFTELPHSPLKFHTYAV 57
Query: 618 TQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDW 677
FSP+ L + S D T LW ++ + A + + R+ C +
Sbjct: 58 HCCCFSPSGHILASCSTDGTTVLWNTENG---------QMLAVMEQPSGSPVRV---CQF 105
Query: 678 SPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQR 737
SPDS +G+ D VV+W + + + C SV D A A S P+
Sbjct: 106 SPDSTCLASGAADGTVVLW-------NAQSYKLYRCGSVKDGSLAACAFS------PNGS 152
Query: 738 YVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNCSGKTEQK 797
+ V G CG + ++ +D C+ + ++H L I C + Q
Sbjct: 153 FFV-TGSSCGDLTVW-----------DDKMRCLHS--EKAHDLGI------TCCDFSSQP 192
Query: 798 EAEGAEWLHF---ASCGEDHTVKI 818
++G + L F ASCG+D VKI
Sbjct: 193 VSDGEQGLQFFRLASCGQDCQVKI 216
Score = 40.0 bits (92), Expect = 0.009
Identities = 69/281 (24%), Positives = 115/281 (40%), Gaps = 67/281 (23%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTE-LVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYA 112
L HT V+C + SPS L S +D + W E+ Q+L AV Q PV
Sbjct: 50 LKFHTYAVHCCCF------SPSGHILASCSTDGTTVLWNTENGQML-AVMEQPSGSPVRV 102
Query: 113 VHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPN 172
+ S + C + S AAD V LW+ + ++ ++ G+ LA C +F PN
Sbjct: 103 C------QFSPDSTC--LASGAADGTVVLWNAQSYKLYRCGSVKDGS---LAAC-AFSPN 150
Query: 173 TDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAF-------GRDLF-L 224
+ D + +D+ + + S H+ I ++++ G F L
Sbjct: 151 GSFFVTGSSCGDLTVW-----DDKMRCLHSEKAHDLGITCCDFSSQPVSDGEQGLQFFRL 205
Query: 225 ASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIENESVKIAFAVTLETVLAGHEN 284
ASC QDC ++IW I + + + F + ++ L+GH
Sbjct: 206 ASCGQDCQVKIW-------------------------IVSFTHILGFELKYKSTLSGHCA 240
Query: 285 WVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEES 325
V A F DG + L+S S+DK++I++ + E+
Sbjct: 241 PVLAC----AFSHDGQM-----LVSGSVDKSVIVYDTNTEN 272
Score = 33.9 bits (76), Expect = 0.63
Identities = 24/101 (23%), Positives = 45/101 (44%), Gaps = 12/101 (11%)
Query: 595 AIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPV 654
++I+++T + + L H+ VT AF+PN L S D+T ++W+
Sbjct: 262 SVIVYDTNTENILHTLTQHTRYVTTCAFAPNTLLLATGSMDKTVNIWQ------------ 309
Query: 655 FSLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVV 695
F L + H ++ DWS + + ++D K +V
Sbjct: 310 FDLETLCQARRTEHQLKQFTEDWSEEDVSTWLCAQDLKDLV 350
Score = 30.4 bits (67), Expect = 7.0
Identities = 11/29 (37%), Positives = 19/29 (65%)
Query: 668 HSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
H+R + +C ++P++ TGS DK V +W
Sbjct: 280 HTRYVTTCAFAPNTLLLATGSMDKTVNIW 308
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 53.1 bits (126), Expect = 1e-06
Identities = 67/300 (22%), Positives = 110/300 (36%), Gaps = 61/300 (20%)
Query: 73 SPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVS 132
S T L +G D W + N A L H+GP++A+ + ++ + I+S
Sbjct: 235 SEGTLLATGSYDGFARIWTKDGNL---ASTLGQHKGPIFALK--WNKKGN------FILS 283
Query: 133 AAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQ 192
A D +W E Q F + A AL + + N +C D C IH+
Sbjct: 284 AGVDKTTIIWDAHTGEAK--QQFPFHS--APALDVDWQSNNT--FASCSTDMC-IHVCKL 336
Query: 193 QNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDN 252
D+ K GH + + ++W G LASCS D ++IW + + D+
Sbjct: 337 GQDRPIKTFQ--GHTNEVNAIKWDPTGN--LLASCSDDMTLKIWSM---------KQDNC 383
Query: 253 IRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASM 312
+ L H + + W P + L SAS
Sbjct: 384 VH-----------------------DLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASF 420
Query: 313 DKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNT 372
D T+ LW D + G+ + + + Y F+ DG + + +F +H+W T
Sbjct: 421 DSTVRLW--DVDRGICIHTLTKHQE-----PVYSVAFSPDGRYLASGSFDKCVHIWNTQT 473
Score = 44.3 bits (103), Expect = 5e-04
Identities = 40/146 (27%), Positives = 65/146 (44%), Gaps = 18/146 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVH-LQGHEG 108
+ GHT VN I+W P+ L++ SD+ + W ++ + VH LQ H
Sbjct: 342 IKTFQGHTNEVNAIKW------DPTGNLLASCSDDMTLKIWSMKQD---NCVHDLQAHNK 392
Query: 109 PVYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCL 167
+Y + + T++P ++ SA+ DS VRLW +C+ TL ++
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDV--DRGICIHTLTKHQEPVYSVAF 450
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQ 193
S D LA G+ D +HI+ Q
Sbjct: 451 S----PDGRYLASGSFDKCVHIWNTQ 472
Score = 40.8 bits (94), Expect = 0.005
Identities = 35/159 (22%), Positives = 63/159 (39%), Gaps = 22/159 (13%)
Query: 278 VLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRV--- 334
VL GHE+ V W PV L S S D T +W E S Q+ +
Sbjct: 164 VLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLSENSTSGSTQLVLRHC 214
Query: 335 ----GEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDG 390
G+ + +N +G+++ ++ G +W ++ + H
Sbjct: 215 IREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWT------KDGNLASTLGQHKGP 268
Query: 391 VQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G FI++ G D+TT ++ + + Q +H
Sbjct: 269 IFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFH 307
Score = 37.0 bits (84), Expect = 0.075
Identities = 34/146 (23%), Positives = 59/146 (40%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
++ GH E+ + + + LLAS + + +W+ V +L H+ +
Sbjct: 342 IKTFQGHTNEVNAIKWDPTGNLLASC-----SDDMTLKIWSMKQDNCVHDLQAHNKEIYT 396
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + + T H
Sbjct: 397 IKWSPTGPGTNNPNANLMLASASFDSTVRLW--------DVDRGICIHTLTK-----HQE 443
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD +Y +GS DK V +W
Sbjct: 444 PVYSVAFSPDGRYLASGSFDKCVHIW 469
Score = 32.3 bits (72), Expect = 1.8
Identities = 22/89 (24%), Positives = 38/89 (42%), Gaps = 4/89 (4%)
Query: 560 VQKLYGHGYEIFCV----TCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSL 615
V L H EI+ + T + A+ A+ + + LW+ + L H
Sbjct: 384 VHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQE 443
Query: 616 TVTQMAFSPNEKFLLAVSRDRTWSLWKKQ 644
V +AFSP+ ++L + S D+ +W Q
Sbjct: 444 PVYSVAFSPDGRYLASGSFDKCVHIWNTQ 472
Score = 32.0 bits (71), Expect = 2.4
Identities = 47/232 (20%), Positives = 84/232 (36%), Gaps = 52/232 (22%)
Query: 22 LNWSSGPRGLLAFGTSCSVVLYDPLKRV------VVTNLNGHTARVNCIQWICKQDGSPS 75
L+W+S GT + YD R+ + + L H + ++W K
Sbjct: 231 LDWNSE-------GTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKK-----G 278
Query: 76 TELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAV----HAVYQRRTSDPALCTLIV 131
++S G D I W+ + + H P V + + ++D +C +
Sbjct: 279 NFILSAGVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQSNNTFASCSTD--MCIHVC 334
Query: 132 SAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFA 191
D ++ + EV ++ GN +LA +DD + I++
Sbjct: 335 KLGQDRPIKTFQGHTNEVNAIKWDPTGN-----------------LLASCSDDMTLKIWS 377
Query: 192 QQNDQFQKVLSLCGHEDWIRGVEWAAFG-------RDLFLASCSQDCLIRIW 236
+ D V L H I ++W+ G +L LAS S D +R+W
Sbjct: 378 MKQDNC--VHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLW 427
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/241 (24%), Positives = 98/241 (40%), Gaps = 21/241 (8%)
Query: 24 WSSGPRGLLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPSTELVSGGS 83
WSS L++ ++ L+D + L GH+ V C + PS ++SG
Sbjct: 91 WSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNF-----NPPSNLIISGSF 145
Query: 84 DNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWS 143
D V WE++ + LK L H PV AVH +LIVS + D R+W
Sbjct: 146 DETVKIWEVKTGKCLKT--LSAHSDPVSAVHF--------NCSGSLIVSGSYDGLCRIWD 195
Query: 144 KKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSL 203
+ CL+TL + ++ + F PN + A D + ++ + K +
Sbjct: 196 AASGQ--CLKTLVDDDNPPVSF-VKFSPNGKYILTA--TLDNTLKLWDYSRGRCLKTYTG 250
Query: 204 CGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDNIRLKENTFTIE 263
+E + ++ G ++ S S+D L+ IW L K + Q ++ + E
Sbjct: 251 HKNEKYCIFANFSVTG-GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTE 309
Query: 264 N 264
N
Sbjct: 310 N 310
Score = 49.3 bits (116), Expect = 1e-05
Identities = 53/223 (23%), Positives = 89/223 (39%), Gaps = 55/223 (24%)
Query: 193 QNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDN 252
+N + +L GH + + V+++ G +LAS S D LI IW
Sbjct: 27 ENPNYALKCTLVGHTEAVSSVKFSPNGE--WLASSSADRLIIIWG--------------- 69
Query: 253 IRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASM 312
A+ E L GH ++ V W RL+SAS
Sbjct: 70 -----------------AYDGKYEKTLYGHNLEISDVAWS---------SDSSRLVSASD 103
Query: 313 DKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNT 372
DKT+ LW D SG L+ ++ G++ + C FN ++II+ +F + +W+ T
Sbjct: 104 DKTLKLW--DVRSGKCLKTLK-----GHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
Query: 373 VNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLF 415
+ +S H D V + ++ G I++ D R++
Sbjct: 157 GKCLK-----TLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/168 (25%), Positives = 69/168 (41%), Gaps = 26/168 (15%)
Query: 563 LYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAF 622
L GH + V + + LAS+ II+W K + L H+L ++ +A+
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASS-----SADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
Query: 623 SPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSK 682
S + L++ S D+T LW + K HS ++ C+++P S
Sbjct: 92 SSDSSRLVSASDDKTLKLWDVRS-------------GKCLKTLKGHSNYVFCCNFNPPSN 138
Query: 683 YFFTGSRDKKVVVW----GECDST----DDCIEHNIGPCSSVLDVGGA 722
+GS D+ V +W G+C T D + CS L V G+
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGS 186
Score = 34.3 bits (77), Expect = 0.49
Identities = 32/152 (21%), Positives = 55/152 (36%), Gaps = 31/152 (20%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
++ L GH +FC N L+ S + +W + K ++ L HS V+
Sbjct: 118 LKTLKGHSNYVFCCNFNPPSNLIISG-----SFDETVKIWEVKTGKCLKTLSAHSDPVSA 172
Query: 620 MAFSPNEKFLLAVSRDRTWSLWKKQD-----TISPEFEPVFSLFAFTNKITSVHSRIIWS 674
+ F+ + +++ S D +W T+ + P S F
Sbjct: 173 VHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKF-------------- 218
Query: 675 CDWSPDSKYFFTGSRDKKVVVW----GECDST 702
SP+ KY T + D + +W G C T
Sbjct: 219 ---SPNGKYILTATLDNTLKLWDYSRGRCLKT 247
Score = 32.3 bits (72), Expect = 1.8
Identities = 42/198 (21%), Positives = 72/198 (36%), Gaps = 45/198 (22%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFH-SLTVT 618
++ L H + V N S +L+ S +W+ S + ++ LV + V+
Sbjct: 160 LKTLSAHSDPVSAVHFNCSGSLIVSG-----SYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 619 QMAFSPNEKFLLAVSRDRTWSLW--------KKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ FSPN K++L + D T LW K E +F+ F+ T
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG-------- 266
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCP 730
K+ +GS D V +W T + ++ G T V +
Sbjct: 267 ----------GKWIVSGSEDNLVYIWNL--QTKEIVQKLQGH-----------TDVVISA 303
Query: 731 VLHPSQRYVVAVGLECGK 748
HP++ + + LE K
Sbjct: 304 ACHPTENLIASAALENDK 321
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 53.1 bits (126), Expect = 1e-06
Identities = 33/101 (32%), Positives = 46/101 (45%), Gaps = 13/101 (12%)
Query: 596 IILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVF 655
++LWN + V H VT + FSP+ L + SRDRT LW P+ F
Sbjct: 42 LMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW------IPDKRGKF 95
Query: 656 SLFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVW 696
S F H+ + S D+S D ++ T S DK + VW
Sbjct: 96 SEF-------KAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Score = 40.0 bits (92), Expect = 0.009
Identities = 50/221 (22%), Positives = 91/221 (41%), Gaps = 35/221 (15%)
Query: 205 GHEDWIRGVEWAAFGRDLFLASCSQDCLIRIW--------KLYIKSTSLETQDDDNIRLK 256
GH+D + V+++ G LAS S+D +R+W + T+ D + +
Sbjct: 58 GHKDVVTSVQFSPHGN--LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
Query: 257 ENTFTIENESVKI--AFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDK 314
E++S+K+ + L H +WV + P DG L ++S S DK
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSP----DGRL-----IVSCSEDK 166
Query: 315 TMILWAPDEESGVWLEQVRVGEVGGNTLGFYD-CQFNEDGSMIIAHAFHGALHLWKQNTV 373
T+ +W + V +++GF + FN G+ I + + +W V
Sbjct: 167 TIKIWDTTNKQCV--------NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR-V 217
Query: 374 NPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 414
N ++ H GV + + P G ++IT +D T ++
Sbjct: 218 NKLLQHYQV----HSGGVNCISFHPSGNYLITASSDGTLKI 254
Score = 35.8 bits (81), Expect = 0.17
Identities = 32/118 (27%), Positives = 52/118 (44%), Gaps = 17/118 (14%)
Query: 35 GTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPSTE-LVSGGSDNQVIHWEIE 93
G+ +V ++D ++ + H+ VNCI + PS L++ SD + ++
Sbjct: 205 GSDQTVKVWDVRVNKLLQHYQVHSGGVNCISF------HPSGNYLITASSDGTLKILDLL 258
Query: 94 DNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMC 151
+ +L+ LQGH GPV+ V S L S AD+ V LW E+ C
Sbjct: 259 EGRLIYT--LQGHTGPVFTV--------SFSKGGELFASGGADTQVLLWRTNFDELHC 306
Score = 35.4 bits (80), Expect = 0.22
Identities = 30/135 (22%), Positives = 56/135 (41%), Gaps = 24/135 (17%)
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
GH + V + LLASA + + LW + H+ V + FS
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASR-----DRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSA 112
Query: 625 NEKFLLAVSRDRT---WSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDS 681
+ +FL S D++ WS+++++ ++SL+ H+ + +SPD
Sbjct: 113 DGQFLATASEDKSIKVWSMYRQRF--------LYSLYR--------HTHWVRCAKFSPDG 156
Query: 682 KYFFTGSRDKKVVVW 696
+ + S DK + +W
Sbjct: 157 RLIVSCSEDKTIKIW 171
Score = 35.0 bits (79), Expect = 0.28
Identities = 31/137 (22%), Positives = 57/137 (41%), Gaps = 25/137 (18%)
Query: 281 GHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGN 340
GH++ V +V + P G L L SAS D+T+ LW PD+ + E +
Sbjct: 58 GHKDVVTSVQFSP----HGNL-----LASASRDRTVRLWIPDKRG-------KFSEFKAH 101
Query: 341 TLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVIS--GHFDGVQDLVWDP 398
T F+ DG + + ++ +W + + S H V+ + P
Sbjct: 102 TAPVRSVDFSADGQFLATASEDKSIKVWSM-------YRQRFLYSLYRHTHWVRCAKFSP 154
Query: 399 EGEFIITVGTDQTTRLF 415
+G I++ D+T +++
Sbjct: 155 DGRLIVSCSEDKTIKIW 171
Score = 32.7 bits (73), Expect = 1.4
Identities = 68/312 (21%), Positives = 117/312 (37%), Gaps = 73/312 (23%)
Query: 386 GHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLA 445
GH D V + + P G + + D+T RL+ P KR S+ + H ++ +
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEF--------KAHTAPVRSVD 109
Query: 446 MINRFQFVSGADE-KVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGL 504
QF++ A E K ++V+S R + F + + V C + S P+G
Sbjct: 110 FSADGQFLATASEDKSIKVWSMYR---QRFLYSLYRHTHWVRCAKFS--PDGRL------ 158
Query: 505 SNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLY 564
I S D+ + T + F S+
Sbjct: 159 ---------IVSCSEDKTIKIWDTTNKQCVNNFSDSV----------------------- 186
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
G+ F V N S T +ASA + +W+ K +Q+ HS V ++F P
Sbjct: 187 --GFANF-VDFNPSGTCIASA-----GSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHP 238
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ +L+ S D T K D + E +++L T + +V +S + F
Sbjct: 239 SGNYLITASSDGT---LKILDLL--EGRLIYTLQGHTGPVFTV--------SFSKGGELF 285
Query: 685 FTGSRDKKVVVW 696
+G D +V++W
Sbjct: 286 ASGGADTQVLLW 297
Score = 32.0 bits (71), Expect = 2.4
Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 13/82 (15%)
Query: 37 SCS----VVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPS-TELVSGGSDNQVIHWE 91
SCS + ++D + V N + N + D +PS T + S GSD V W+
Sbjct: 161 SCSEDKTIKIWDTTNKQCVNNFSDSVGFANFV------DFNPSGTCIASAGSDQTVKVWD 214
Query: 92 IEDNQLLKAVHLQGHEGPVYAV 113
+ N+LL+ H Q H G V +
Sbjct: 215 VRVNKLLQ--HYQVHSGGVNCI 234
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 51.2 bits (121), Expect = 4e-06
Identities = 65/296 (21%), Positives = 105/296 (35%), Gaps = 61/296 (20%)
Query: 73 SPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVS 132
S T L G D W N A L H+GP++A+ + ++ + ++S
Sbjct: 245 SDGTLLAMGSYDGFARIWTENGNL---ASTLGQHKGPIFALK--WNKKGN------YVLS 293
Query: 133 AAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQ 192
A D +W E Q F + AL + ++ +C D C IH+
Sbjct: 294 AGVDKTTIIWDAHTGEAK--QQFPFHSAPALDVDWQ----NNMTFASCSTDMC-IHVCRL 346
Query: 193 QNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDN 252
D K GH + + ++W G + LASCS D ++IW +
Sbjct: 347 GCDHPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIWSM-------------- 388
Query: 253 IRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASM 312
K++ + L H + + W P + L SAS
Sbjct: 389 ---KQDACVHD---------------LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 313 DKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLW 368
D T+ LW D E GV + + Y F+ DG + + +F +H+W
Sbjct: 431 DSTVRLW--DVEQGVCTHTLMKHQE-----PVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/147 (29%), Positives = 67/147 (45%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVH-LQGHEG 108
V GHT VN I+W PS L++ SD+ + W ++ + VH LQ H
Sbjct: 352 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSK 402
Query: 109 PVYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW + + +C TL ++
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE--QGVCTHTLMKHQEPVYSVAF 460
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 461 S----PDGKYLASGSFDKYVHIWNTQS 483
Score = 44.7 bits (104), Expect = 4e-04
Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 173 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N DG+++ ++ G +W +N + H
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG------NLASTLGQHKG 277
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G ++++ G D+TT ++ + + Q +H
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFH 317
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/146 (26%), Positives = 60/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ V +L HS +
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ + H
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC------------THTLMK-HQE 453
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 33.5 bits (75), Expect = 0.83
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 560 VQKLYGHGYEIFCV----TCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSL 615
V L H EI+ + T ++ +S A+ + + LW+ L+ H
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
Query: 616 TVTQMAFSPNEKFLLAVSRDRTWSLWKKQ 644
V +AFSP+ K+L + S D+ +W Q
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIWNTQ 482
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 51.2 bits (121), Expect = 4e-06
Identities = 65/296 (21%), Positives = 105/296 (35%), Gaps = 61/296 (20%)
Query: 73 SPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVS 132
S T L G D W N A L H+GP++A+ + ++ + ++S
Sbjct: 245 SDGTLLAMGSYDGFARIWTENGNL---ASTLGQHKGPIFALK--WNKKGN------YVLS 293
Query: 133 AAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQ 192
A D +W E Q F + AL + ++ +C D C IH+
Sbjct: 294 AGVDKTTIIWDAHTGEAK--QQFPFHSAPALDVDWQ----NNMTFASCSTDMC-IHVCRL 346
Query: 193 QNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDN 252
D K GH + + ++W G + LASCS D ++IW +
Sbjct: 347 GCDHPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIWSM-------------- 388
Query: 253 IRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASM 312
K++ + L H + + W P + L SAS
Sbjct: 389 ---KQDACVHD---------------LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 313 DKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLW 368
D T+ LW D E GV + + Y F+ DG + + +F +H+W
Sbjct: 431 DSTVRLW--DVEQGVCTHTLMKHQE-----PVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/147 (29%), Positives = 67/147 (45%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVH-LQGHEG 108
V GHT VN I+W PS L++ SD+ + W ++ + VH LQ H
Sbjct: 352 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSK 402
Query: 109 PVYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW + + +C TL ++
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE--QGVCTHTLMKHQEPVYSVAF 460
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 461 S----PDGKYLASGSFDKYVHIWNTQS 483
Score = 44.7 bits (104), Expect = 4e-04
Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 173 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N DG+++ ++ G +W +N + H
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG------NLASTLGQHKG 277
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G ++++ G D+TT ++ + + Q +H
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFH 317
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/146 (26%), Positives = 60/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ V +L HS +
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ + H
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC------------THTLMK-HQE 453
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 33.5 bits (75), Expect = 0.83
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 560 VQKLYGHGYEIFCV----TCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSL 615
V L H EI+ + T ++ +S A+ + + LW+ L+ H
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
Query: 616 TVTQMAFSPNEKFLLAVSRDRTWSLWKKQ 644
V +AFSP+ K+L + S D+ +W Q
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIWNTQ 482
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 51.2 bits (121), Expect = 4e-06
Identities = 65/296 (21%), Positives = 105/296 (35%), Gaps = 61/296 (20%)
Query: 73 SPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVS 132
S T L G D W N A L H+GP++A+ + ++ + ++S
Sbjct: 245 SDGTLLAMGSYDGFARIWTENGNL---ASTLGQHKGPIFALK--WNKKGN------YVLS 293
Query: 133 AAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNTDVPILACGNDDCRIHIFAQ 192
A D +W E Q F + AL + ++ +C D C IH+
Sbjct: 294 AGVDKTTIIWDAHTGEAK--QQFPFHSAPALDVDWQ----NNMTFASCSTDMC-IHVCRL 346
Query: 193 QNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTSLETQDDDN 252
D K GH + + ++W G + LASCS D ++IW +
Sbjct: 347 GCDHPVKTFQ--GHTNEVNAIKWDPSG--MLLASCSDDMTLKIWSM-------------- 388
Query: 253 IRLKENTFTIENESVKIAFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASM 312
K++ + L H + + W P + L SAS
Sbjct: 389 ---KQDACVHD---------------LQAHSKEIYTIKWSPTGPATSNPNSSIMLASASF 430
Query: 313 DKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLW 368
D T+ LW D E GV + + Y F+ DG + + +F +H+W
Sbjct: 431 DSTVRLW--DVEQGVCTHTLMKHQE-----PVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/147 (29%), Positives = 67/147 (45%), Gaps = 18/147 (12%)
Query: 51 VTNLNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIH-WEIEDNQLLKAVH-LQGHEG 108
V GHT VN I+W PS L++ SD+ + W ++ + VH LQ H
Sbjct: 352 VKTFQGHTNEVNAIKW------DPSGMLLASCSDDMTLKIWSMKQDA---CVHDLQAHSK 402
Query: 109 PVYAVH-AVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCL 167
+Y + + TS+P ++ SA+ DS VRLW + + +C TL ++
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVE--QGVCTHTLMKHQEPVYSVAF 460
Query: 168 SFLPNTDVPILACGNDDCRIHIFAQQN 194
S D LA G+ D +HI+ Q+
Sbjct: 461 S----PDGKYLASGSFDKYVHIWNTQS 483
Score = 44.7 bits (104), Expect = 4e-04
Identities = 37/160 (23%), Positives = 66/160 (41%), Gaps = 22/160 (13%)
Query: 277 TVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGE 336
TVL GHE+ V W PV L S S D T +W +E S Q+ +
Sbjct: 173 TVLRGHESEVFICAWNPV---------SDLLASGSGDSTARIWNLNENSNGGSTQLVLRH 223
Query: 337 V---GGNTL----GFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFD 389
GG+ + +N DG+++ ++ G +W +N + H
Sbjct: 224 CIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENG------NLASTLGQHKG 277
Query: 390 GVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWH 429
+ L W+ +G ++++ G D+TT ++ + + Q +H
Sbjct: 278 PIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFH 317
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/146 (26%), Positives = 60/146 (41%), Gaps = 27/146 (18%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
V+ GH E+ + + S LLAS + + +W+ V +L HS +
Sbjct: 352 VKTFQGHTNEVNAIKWDPSGMLLASC-----SDDMTLKIWSMKQDACVHDLQAHSKEIYT 406
Query: 620 MAFSP--------NEKFLLA-VSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSR 670
+ +SP N +LA S D T LW + + T+ + H
Sbjct: 407 IKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVC------------THTLMK-HQE 453
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVW 696
++S +SPD KY +GS DK V +W
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIW 479
Score = 33.5 bits (75), Expect = 0.83
Identities = 23/89 (25%), Positives = 39/89 (43%), Gaps = 4/89 (4%)
Query: 560 VQKLYGHGYEIFCV----TCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSL 615
V L H EI+ + T ++ +S A+ + + LW+ L+ H
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453
Query: 616 TVTQMAFSPNEKFLLAVSRDRTWSLWKKQ 644
V +AFSP+ K+L + S D+ +W Q
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIWNTQ 482
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 49.7 bits (117), Expect = 1e-05
Identities = 42/167 (25%), Positives = 69/167 (41%), Gaps = 22/167 (13%)
Query: 273 VTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILW-APDEESGVWLEQ 331
+TL L GH WV + P F P +LSAS DKT+I+W +E+ + Q
Sbjct: 5 MTLRGTLKGHNGWVTQIATTPQF--------PDMILSASRDKTIIMWKLTRDETNYGIPQ 56
Query: 332 VRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGV 391
+ G++ D + DG ++ ++ G L LW T T GH V
Sbjct: 57 ---RALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTT-----GTTTRRFVGHTKDV 108
Query: 392 QDLVWDPEGEFIITVGTDQTTRLF-----APWKRKDQSQVTWHEIAR 433
+ + + I++ D+T +L+ + +D+S W R
Sbjct: 109 LSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVR 155
Score = 34.3 bits (77), Expect = 0.49
Identities = 15/44 (34%), Positives = 26/44 (59%)
Query: 598 LWNTTSWKQVQNLVFHSLTVTQMAFSPNEKFLLAVSRDRTWSLW 641
LW+ T+ + V H+ V +AFS + + +++ SRD+T LW
Sbjct: 89 LWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
Score = 33.5 bits (75), Expect = 0.83
Identities = 45/216 (20%), Positives = 80/216 (37%), Gaps = 47/216 (21%)
Query: 613 HSLTVTQMAFSPN-EKFLLAVSRDRTWSLWK-KQDTISPEFEPVFSLFAFTNKITSVHSR 670
H+ VTQ+A +P +L+ SRD+T +WK +D + + + HS
Sbjct: 14 HNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETN---------YGIPQRALRGHSH 64
Query: 671 IIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCP 730
+ S D ++ +GS D + +W +T +G VL V +
Sbjct: 65 FVSDVVISSDGQFALSGSWDGTLRLWDL--TTGTTTRRFVGHTKDVLSV---AFSSDNRQ 119
Query: 731 VLHPSQRYVVAVGLECGKICLYTWKKTDQVPEINDWTHCVETSQSQSHTLAIRKLCWKNC 790
++ S+ + + G +C YT + ++W CV S + S+ + +
Sbjct: 120 IVSGSRDKTIKLWNTLG-VCKYTVQDESH----SEWVSCVRFSPNSSNPIIV-------- 166
Query: 791 SGKTEQKEAEGAEWLHFASCGEDHTVKIHRVNKCAL 826
SCG D VK+ + C L
Sbjct: 167 ------------------SCGWDKLVKVWNLANCKL 184
Score = 33.1 bits (74), Expect = 1.1
Identities = 33/131 (25%), Positives = 55/131 (41%), Gaps = 19/131 (14%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAV 113
L GH+ V+ + + DG + +SG D + W++ + GH V +V
Sbjct: 59 LRGHSHFVSDV--VISSDGQFA---LSGSWDGTLRLWDLTTGTTTR--RFVGHTKDVLSV 111
Query: 114 HAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNT 173
R IVS + D ++LW+ G +C T+ + C+ F PN+
Sbjct: 112 AFSSDNRQ--------IVSGSRDKTIKLWNTLG---VCKYTVQDESHSEWVSCVRFSPNS 160
Query: 174 DVPIL-ACGND 183
PI+ +CG D
Sbjct: 161 SNPIIVSCGWD 171
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 1e-05
Identities = 59/244 (24%), Positives = 110/244 (45%), Gaps = 42/244 (17%)
Query: 202 SLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLY-------IKSTSLETQD----- 249
+L GH + V+++ G +LAS S D LI+IW Y I L D
Sbjct: 40 TLAGHTKAVSSVKFSPNGE--WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 250 DDNIRLKENTFTIENESVKI---AFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVR 306
D N+ + + +++++KI + L+T L GH N+V ++ P Q
Sbjct: 98 DSNLLVSAS----DDKTLKIWDVSSGKCLKT-LKGHSNYVFCCNFNP---------QSNL 143
Query: 307 LLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALH 366
++S S D+++ +W D ++G L+ + + + FN DGS+I++ ++ G
Sbjct: 144 IVSGSFDESVRIW--DVKTGKCLKTLPAHSDPVSAV-----HFNRDGSLIVSSSYDGLCR 196
Query: 367 LWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQV 426
+W +T + + + +I V + + P G++I+ D T +L+ K K
Sbjct: 197 IW--DTASGQ--CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Query: 427 TWHE 430
T H+
Sbjct: 253 TGHK 256
Score = 44.7 bits (104), Expect = 4e-04
Identities = 67/316 (21%), Positives = 117/316 (37%), Gaps = 35/316 (11%)
Query: 337 VGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVW 396
+ G+T +F+ +G + + + + +W + E ISGH G+ D+ W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISDVAW 95
Query: 397 DPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGA 456
+ +++ D+T +++ K + H Y C VSG+
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS-------NYVFCCNFNPQSNLIVSGS 148
Query: 457 DEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIAS 516
++ +R++ ++ V N+D L ++ L G
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLK 207
Query: 517 QPSDEEELLTSTGFEYQQVAFQPS---ILTEPPTEDHLLQNTLWP----EVQKLY-GHGY 568
D++ S V F P+ IL T D+ L+ LW + K Y GH
Sbjct: 208 TLIDDDNPPVSF------VKFSPNGKYILAA--TLDNTLK--LWDYSKGKCLKTYTGHKN 257
Query: 569 EIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKF 628
E +C+ N S T + E + +WN + + VQ L H+ V A P E
Sbjct: 258 EKYCIFANFSVT--GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 629 L--LAVSRDRTWSLWK 642
+ A+ D+T LWK
Sbjct: 316 IASAALENDKTIKLWK 331
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 22/144 (15%)
Query: 563 LYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAF 622
L GH + V + + LAS+ +A K I +W K + + H L ++ +A+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASS--SADK---LIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 623 SPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSK 682
S + L++ S D+T +W D S + K HS ++ C+++P S
Sbjct: 96 SSDSNLLVSASDDKTLKIW---DVSSGK----------CLKTLKGHSNYVFCCNFNPQSN 142
Query: 683 YFFTGSRDKKVVVW----GECDST 702
+GS D+ V +W G+C T
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKT 166
Score = 40.8 bits (94), Expect = 0.005
Identities = 60/283 (21%), Positives = 110/283 (38%), Gaps = 46/283 (16%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAV 113
++GH ++ + W S S LVS D + W++ + LK L+GH V+
Sbjct: 83 ISGHKLGISDVAW-----SSDSNLLVSASDDKTLKIWDVSSGKCLKT--LKGHSNYVFCC 135
Query: 114 HAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNT 173
+ Q LIVS + D +VR+W K + CL+TL + A+ N
Sbjct: 136 NFNPQSN--------LIVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHF----NR 181
Query: 174 DVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLI 233
D ++ + D I+ + Q K L + + V+++ G+ ++ + + D +
Sbjct: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGK--YILAATLDNTL 238
Query: 234 RIWKLYIKSTSLETQDDD---------NIRLKENTFTIENESVKIAFAVTLET-----VL 279
++W Y K L+T N + + + + + L+T L
Sbjct: 239 KLWD-YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 297
Query: 280 AGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPD 322
GH + V + P + + + DKT+ LW D
Sbjct: 298 QGHTDVVISTACHPT-------ENIIASAALENDKTIKLWKSD 333
Score = 35.4 bits (80), Expect = 0.22
Identities = 36/159 (22%), Positives = 66/159 (41%), Gaps = 25/159 (15%)
Query: 598 LWNTTSWKQVQNLVFH-SLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFS 656
+W+T S + ++ L+ + V+ + FSPN K++LA + D T LW ++
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--------DYSKGKC 248
Query: 657 LFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSV 716
L +T + I++ K+ +GS D V +W T + ++ G
Sbjct: 249 LKTYTGHKNEKY--CIFANFSVTGGKWIVSGSEDNLVYIWNL--QTKEIVQKLQGH---- 300
Query: 717 LDVGGAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWK 755
T V + HP++ + + LE K + WK
Sbjct: 301 -------TDVVISTACHPTENIIASAALENDK-TIKLWK 331
Score = 35.0 bits (79), Expect = 0.28
Identities = 33/147 (22%), Positives = 61/147 (41%), Gaps = 21/147 (14%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
++ L GH +FC N L+ S ++ +W+ + K ++ L HS V+
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSG-----SFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 620 MAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSP 679
+ F+ + +++ S D +W DT S + + +L N S +SP
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIW---DTASGQC--LKTLIDDDNPPVSF-------VKFSP 224
Query: 680 DSKYFFTGSRDKKVVVW----GECDST 702
+ KY + D + +W G+C T
Sbjct: 225 NGKYILAATLDNTLKLWDYSKGKCLKT 251
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 49.7 bits (117), Expect = 1e-05
Identities = 59/244 (24%), Positives = 110/244 (45%), Gaps = 42/244 (17%)
Query: 202 SLCGHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLY-------IKSTSLETQD----- 249
+L GH + V+++ G +LAS S D LI+IW Y I L D
Sbjct: 40 TLAGHTKAVSSVKFSPNGE--WLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSS 97
Query: 250 DDNIRLKENTFTIENESVKI---AFAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVR 306
D N+ + + +++++KI + L+T L GH N+V ++ P Q
Sbjct: 98 DSNLLVSAS----DDKTLKIWDVSSGKCLKT-LKGHSNYVFCCNFNP---------QSNL 143
Query: 307 LLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALH 366
++S S D+++ +W D ++G L+ + + + FN DGS+I++ ++ G
Sbjct: 144 IVSGSFDESVRIW--DVKTGKCLKTLPAHSDPVSAV-----HFNRDGSLIVSSSYDGLCR 196
Query: 367 LWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQV 426
+W +T + + + +I V + + P G++I+ D T +L+ K K
Sbjct: 197 IW--DTASGQ--CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
Query: 427 TWHE 430
T H+
Sbjct: 253 TGHK 256
Score = 44.7 bits (104), Expect = 4e-04
Identities = 67/316 (21%), Positives = 117/316 (37%), Gaps = 35/316 (11%)
Query: 337 VGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVW 396
+ G+T +F+ +G + + + + +W + E ISGH G+ D+ W
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIW-----GAYDGKFEKTISGHKLGISDVAW 95
Query: 397 DPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMINRFQFVSGA 456
+ +++ D+T +++ K + H Y C VSG+
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHS-------NYVFCCNFNPQSNLIVSGS 148
Query: 457 DEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGLSNKAVFQGDIAS 516
++ +R++ ++ V N+D L ++ L G
Sbjct: 149 FDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA-SGQCLK 207
Query: 517 QPSDEEELLTSTGFEYQQVAFQPS---ILTEPPTEDHLLQNTLWP----EVQKLY-GHGY 568
D++ S V F P+ IL T D+ L+ LW + K Y GH
Sbjct: 208 TLIDDDNPPVSF------VKFSPNGKYILAA--TLDNTLK--LWDYSKGKCLKTYTGHKN 257
Query: 569 EIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSPNEKF 628
E +C+ N S T + E + +WN + + VQ L H+ V A P E
Sbjct: 258 EKYCIFANFSVT--GGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENI 315
Query: 629 L--LAVSRDRTWSLWK 642
+ A+ D+T LWK
Sbjct: 316 IASAALENDKTIKLWK 331
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 22/144 (15%)
Query: 563 LYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAF 622
L GH + V + + LAS+ +A K I +W K + + H L ++ +A+
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASS--SADK---LIKIWGAYDGKFEKTISGHKLGISDVAW 95
Query: 623 SPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSK 682
S + L++ S D+T +W D S + K HS ++ C+++P S
Sbjct: 96 SSDSNLLVSASDDKTLKIW---DVSSGK----------CLKTLKGHSNYVFCCNFNPQSN 142
Query: 683 YFFTGSRDKKVVVW----GECDST 702
+GS D+ V +W G+C T
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKT 166
Score = 40.8 bits (94), Expect = 0.005
Identities = 60/283 (21%), Positives = 110/283 (38%), Gaps = 46/283 (16%)
Query: 54 LNGHTARVNCIQWICKQDGSPSTELVSGGSDNQVIHWEIEDNQLLKAVHLQGHEGPVYAV 113
++GH ++ + W S S LVS D + W++ + LK L+GH V+
Sbjct: 83 ISGHKLGISDVAW-----SSDSNLLVSASDDKTLKIWDVSSGKCLKT--LKGHSNYVFCC 135
Query: 114 HAVYQRRTSDPALCTLIVSAAADSAVRLWSKKGPEVMCLQTLNFGNGFALALCLSFLPNT 173
+ Q LIVS + D +VR+W K + CL+TL + A+ N
Sbjct: 136 NFNPQSN--------LIVSGSFDESVRIWDVKTGK--CLKTLPAHSDPVSAVHF----NR 181
Query: 174 DVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLASCSQDCLI 233
D ++ + D I+ + Q K L + + V+++ G+ ++ + + D +
Sbjct: 182 DGSLIVSSSYDGLCRIWDTASGQCLKTL-IDDDNPPVSFVKFSPNGK--YILAATLDNTL 238
Query: 234 RIWKLYIKSTSLETQDDD---------NIRLKENTFTIENESVKIAFAVTLET-----VL 279
++W Y K L+T N + + + + + L+T L
Sbjct: 239 KLWD-YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL 297
Query: 280 AGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPD 322
GH + V + P + + + DKT+ LW D
Sbjct: 298 QGHTDVVISTACHPT-------ENIIASAALENDKTIKLWKSD 333
Score = 35.4 bits (80), Expect = 0.22
Identities = 36/159 (22%), Positives = 66/159 (41%), Gaps = 25/159 (15%)
Query: 598 LWNTTSWKQVQNLVFH-SLTVTQMAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFS 656
+W+T S + ++ L+ + V+ + FSPN K++LA + D T LW ++
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--------DYSKGKC 248
Query: 657 LFAFTNKITSVHSRIIWSCDWSPDSKYFFTGSRDKKVVVWGECDSTDDCIEHNIGPCSSV 716
L +T + I++ K+ +GS D V +W T + ++ G
Sbjct: 249 LKTYTGHKNEKY--CIFANFSVTGGKWIVSGSEDNLVYIWNL--QTKEIVQKLQGH---- 300
Query: 717 LDVGGAVTAVSVCPVLHPSQRYVVAVGLECGKICLYTWK 755
T V + HP++ + + LE K + WK
Sbjct: 301 -------TDVVISTACHPTENIIASAALENDK-TIKLWK 331
Score = 35.0 bits (79), Expect = 0.28
Identities = 33/147 (22%), Positives = 61/147 (41%), Gaps = 21/147 (14%)
Query: 560 VQKLYGHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQ 619
++ L GH +FC N L+ S ++ +W+ + K ++ L HS V+
Sbjct: 122 LKTLKGHSNYVFCCNFNPQSNLIVSG-----SFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 620 MAFSPNEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSP 679
+ F+ + +++ S D +W DT S + + +L N S +SP
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIW---DTASGQC--LKTLIDDDNPPVSF-------VKFSP 224
Query: 680 DSKYFFTGSRDKKVVVW----GECDST 702
+ KY + D + +W G+C T
Sbjct: 225 NGKYILAATLDNTLKLWDYSKGKCLKT 251
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/324 (20%), Positives = 121/324 (37%), Gaps = 74/324 (22%)
Query: 385 SGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCL 444
+GH D V + + P G + + D+T R++ P + + + H +H
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS---- 75
Query: 445 AMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGL 504
+ FV+ +D+K ++V++ R + F Q +N V C + S P+G + +
Sbjct: 76 ---DGQSFVTASDDKTVKVWATHR---QKFLFSLSQHINWVRCAKFS--PDGRLIVSAS- 126
Query: 505 SNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLY 564
+K V D +S+ V
Sbjct: 127 DDKTVKLWDKSSREC----------------------------------------VHSYC 146
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
HG + V + S T C AA + +W+ + + +Q+ HS V ++F P
Sbjct: 147 EHGGFVTYVDFHPSGT-----CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 201
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ +L+ S D T + E +++L T+V +S +YF
Sbjct: 202 SGNYLITASSDSTLKILDLM-----EGRLLYTLHGHQGPATTV--------AFSRTGEYF 248
Query: 685 FTGSRDKKVVVWGECDSTDDCIEH 708
+G D++V+VW S D ++H
Sbjct: 249 ASGGSDEQVMVW---KSNFDIVDH 269
Score = 43.5 bits (101), Expect = 8e-04
Identities = 46/181 (25%), Positives = 74/181 (40%), Gaps = 31/181 (17%)
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
GH + CV + S LLAS + + +W + H+ TV + F
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSR-----DKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 75
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ + + S D+T +W T +F +FSL S H + +SPD +
Sbjct: 76 DGQSFVTASDDKTVKVWA---THRQKF--LFSL--------SQHINWVRCAKFSPDGRLI 122
Query: 685 FTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGL 744
+ S DK V +W + S+ +C+ S + GG VT V HPS + A G+
Sbjct: 123 VSASDDKTVKLWDK--SSRECVH-------SYCEHGGFVTYVD----FHPSGTCIAAAGM 169
Query: 745 E 745
+
Sbjct: 170 D 170
Score = 42.7 bits (99), Expect = 0.001
Identities = 56/220 (25%), Positives = 87/220 (39%), Gaps = 33/220 (15%)
Query: 205 GHEDWIRGVEWAAFGRDLFLASCSQDCLIRIWKLYIKSTS------LETQDDDNIRLKEN 258
GH+D + V ++ G LAS S+D +RIW +K S T +
Sbjct: 21 GHKDAVTCVNFSPSGH--LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78
Query: 259 TFTIENESVKIAFAVTLET----VLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDK 314
+F ++ + T L+ H NWV + P DG L ++SAS DK
Sbjct: 79 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP----DGRL-----IVSASDDK 129
Query: 315 TMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVN 374
T+ LW D+ S E V G + + D F+ G+ I A + +W T
Sbjct: 130 TVKLW--DKSS---RECVHSYCEHGGFVTYVD--FHPSGTCIAAAGMDNTVKVWDVRTHR 182
Query: 375 PREWTPEIVISGHFDGVQDLVWDPEGEFIITVGTDQTTRL 414
+ H V L + P G ++IT +D T ++
Sbjct: 183 LLQH-----YQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 33.5 bits (75), Expect = 0.83
Identities = 33/159 (20%), Positives = 60/159 (37%), Gaps = 34/159 (21%)
Query: 281 GHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGN 340
GH++ V V++ P G L L S S DKT+ +W P+ + + + V
Sbjct: 21 GHKDAVTCVNFSP----SGHL-----LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS- 70
Query: 341 TLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEG 400
F DG + + + +W + +S H + V+ + P+G
Sbjct: 71 ------VHFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKFSPDG 119
Query: 401 EFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGY 439
I++ D+T +L W + +R +H Y
Sbjct: 120 RLIVSASDDKTVKL-------------WDKSSRECVHSY 145
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/324 (20%), Positives = 121/324 (37%), Gaps = 74/324 (22%)
Query: 385 SGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCL 444
+GH D V + + P G + + D+T R++ P + + + H +H
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS---- 113
Query: 445 AMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGL 504
+ FV+ +D+K ++V++ R + F Q +N V C + S P+G + +
Sbjct: 114 ---DGQSFVTASDDKTVKVWATHR---QKFLFSLSQHINWVRCAKFS--PDGRLIVSAS- 164
Query: 505 SNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLY 564
+K V D +S+ V
Sbjct: 165 DDKTVKLWDKSSREC----------------------------------------VHSYC 184
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
HG + V + S T C AA + +W+ + + +Q+ HS V ++F P
Sbjct: 185 EHGGFVTYVDFHPSGT-----CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ +L+ S D T + E +++L T+V +S +YF
Sbjct: 240 SGNYLITASSDSTLKILDLM-----EGRLLYTLHGHQGPATTV--------AFSRTGEYF 286
Query: 685 FTGSRDKKVVVWGECDSTDDCIEH 708
+G D++V+VW S D ++H
Sbjct: 287 ASGGSDEQVMVW---KSNFDIVDH 307
Score = 45.1 bits (105), Expect = 3e-04
Identities = 64/259 (24%), Positives = 102/259 (39%), Gaps = 37/259 (14%)
Query: 166 CLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLA 225
C+ F NT LA G+ D + ++ + + GH+D + V ++ G LA
Sbjct: 24 CVDFSINTKQ--LASGSMDSCLMVWHMKPQS--RAYRFTGHKDAVTCVNFSPSGH--LLA 77
Query: 226 SCSQDCLIRIWKLYIKSTS------LETQDDDNIRLKENTFTIENESVKIAFAVTLET-- 277
S S+D +RIW +K S T + +F ++ + T
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 278 --VLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVG 335
L+ H NWV + P DG L ++SAS DKT+ LW D+ S E V
Sbjct: 138 LFSLSQHINWVRCAKFSP----DGRL-----IVSASDDKTVKLW--DKSS---RECVHSY 183
Query: 336 EVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLV 395
G + + D F+ G+ I A + +W T + H V L
Sbjct: 184 CEHGGFVTYVD--FHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-----YQLHSAAVNGLS 236
Query: 396 WDPEGEFIITVGTDQTTRL 414
+ P G ++IT +D T ++
Sbjct: 237 FHPSGNYLITASSDSTLKI 255
Score = 43.5 bits (101), Expect = 8e-04
Identities = 46/181 (25%), Positives = 74/181 (40%), Gaps = 31/181 (17%)
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
GH + CV + S LLAS + + +W + H+ TV + F
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSR-----DKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ + + S D+T +W T +F +FSL S H + +SPD +
Sbjct: 114 DGQSFVTASDDKTVKVWA---THRQKF--LFSL--------SQHINWVRCAKFSPDGRLI 160
Query: 685 FTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGL 744
+ S DK V +W + S+ +C+ S + GG VT V HPS + A G+
Sbjct: 161 VSASDDKTVKLWDK--SSRECVH-------SYCEHGGFVTYVD----FHPSGTCIAAAGM 207
Query: 745 E 745
+
Sbjct: 208 D 208
Score = 33.5 bits (75), Expect = 0.83
Identities = 33/159 (20%), Positives = 60/159 (37%), Gaps = 34/159 (21%)
Query: 281 GHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGN 340
GH++ V V++ P G L L S S DKT+ +W P+ + + + V
Sbjct: 59 GHKDAVTCVNFSP----SGHL-----LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS- 108
Query: 341 TLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEG 400
F DG + + + +W + +S H + V+ + P+G
Sbjct: 109 ------VHFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKFSPDG 157
Query: 401 EFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGY 439
I++ D+T +L W + +R +H Y
Sbjct: 158 RLIVSASDDKTVKL-------------WDKSSRECVHSY 183
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 48.9 bits (115), Expect = 2e-05
Identities = 65/324 (20%), Positives = 121/324 (37%), Gaps = 74/324 (22%)
Query: 385 SGHFDGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCL 444
+GH D V + + P G + + D+T R++ P + + + H +H
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCS---- 113
Query: 445 AMINRFQFVSGADEKVLRVFSAPRNFVENFCAITGQSLNHVLCNQDSDLPEGATVPALGL 504
+ FV+ +D+K ++V++ R + F Q +N V C + S P+G + +
Sbjct: 114 ---DGQSFVTASDDKTVKVWATHR---QKFLFSLSQHINWVRCAKFS--PDGRLIVSAS- 164
Query: 505 SNKAVFQGDIASQPSDEEELLTSTGFEYQQVAFQPSILTEPPTEDHLLQNTLWPEVQKLY 564
+K V D +S+ V
Sbjct: 165 DDKTVKLWDKSSREC----------------------------------------VHSYC 184
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
HG + V + S T C AA + +W+ + + +Q+ HS V ++F P
Sbjct: 185 EHGGFVTYVDFHPSGT-----CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHP 239
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ +L+ S D T + E +++L T+V +S +YF
Sbjct: 240 SGNYLITASSDSTLKILDLM-----EGRLLYTLHGHQGPATTV--------AFSRTGEYF 286
Query: 685 FTGSRDKKVVVWGECDSTDDCIEH 708
+G D++V+VW S D ++H
Sbjct: 287 ASGGSDEQVMVW---KSNFDIVDH 307
Score = 45.1 bits (105), Expect = 3e-04
Identities = 64/259 (24%), Positives = 102/259 (39%), Gaps = 37/259 (14%)
Query: 166 CLSFLPNTDVPILACGNDDCRIHIFAQQNDQFQKVLSLCGHEDWIRGVEWAAFGRDLFLA 225
C+ F NT LA G+ D + ++ + + GH+D + V ++ G LA
Sbjct: 24 CVDFSINTKQ--LASGSMDSCLMVWHMKPQS--RAYRFTGHKDAVTCVNFSPSGH--LLA 77
Query: 226 SCSQDCLIRIWKLYIKSTS------LETQDDDNIRLKENTFTIENESVKIAFAVTLET-- 277
S S+D +RIW +K S T + +F ++ + T
Sbjct: 78 SGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF 137
Query: 278 --VLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVG 335
L+ H NWV + P DG L ++SAS DKT+ LW D+ S E V
Sbjct: 138 LFSLSQHINWVRCAKFSP----DGRL-----IVSASDDKTVKLW--DKSS---RECVHSY 183
Query: 336 EVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLV 395
G + + D F+ G+ I A + +W T + H V L
Sbjct: 184 CEHGGFVTYVD--FHPSGTCIAAAGMDNTVKVWDVRTHRLLQH-----YQLHSAAVNGLS 236
Query: 396 WDPEGEFIITVGTDQTTRL 414
+ P G ++IT +D T ++
Sbjct: 237 FHPSGNYLITASSDSTLKI 255
Score = 43.5 bits (101), Expect = 8e-04
Identities = 46/181 (25%), Positives = 74/181 (40%), Gaps = 31/181 (17%)
Query: 565 GHGYEIFCVTCNSSKTLLASACKAAKKEHAAIILWNTTSWKQVQNLVFHSLTVTQMAFSP 624
GH + CV + S LLAS + + +W + H+ TV + F
Sbjct: 59 GHKDAVTCVNFSPSGHLLASGSR-----DKTVRIWVPNVKGESTVFRAHTATVRSVHFCS 113
Query: 625 NEKFLLAVSRDRTWSLWKKQDTISPEFEPVFSLFAFTNKITSVHSRIIWSCDWSPDSKYF 684
+ + + S D+T +W T +F +FSL S H + +SPD +
Sbjct: 114 DGQSFVTASDDKTVKVWA---THRQKF--LFSL--------SQHINWVRCAKFSPDGRLI 160
Query: 685 FTGSRDKKVVVWGECDSTDDCIEHNIGPCSSVLDVGGAVTAVSVCPVLHPSQRYVVAVGL 744
+ S DK V +W + S+ +C+ S + GG VT V HPS + A G+
Sbjct: 161 VSASDDKTVKLWDK--SSRECVH-------SYCEHGGFVTYVD----FHPSGTCIAAAGM 207
Query: 745 E 745
+
Sbjct: 208 D 208
Score = 33.5 bits (75), Expect = 0.83
Identities = 33/159 (20%), Positives = 60/159 (37%), Gaps = 34/159 (21%)
Query: 281 GHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGN 340
GH++ V V++ P G L L S S DKT+ +W P+ + + + V
Sbjct: 59 GHKDAVTCVNFSP----SGHL-----LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS- 108
Query: 341 TLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHFDGVQDLVWDPEG 400
F DG + + + +W + +S H + V+ + P+G
Sbjct: 109 ------VHFCSDGQSFVTASDDKTVKVWATHRQKFL-----FSLSQHINWVRCAKFSPDG 157
Query: 401 EFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGY 439
I++ D+T +L W + +R +H Y
Sbjct: 158 RLIVSASDDKTVKL-------------WDKSSRECVHSY 183
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 48.9 bits (115), Expect = 2e-05
Identities = 60/254 (23%), Positives = 111/254 (43%), Gaps = 39/254 (15%)
Query: 224 LASCSQDCLIRIWKL-------YIKSTSLETQDDDNIRLKENTFTIENES----VKI--A 270
L + +D +IRIW + YI S T ++I L N T+ + S VK+ A
Sbjct: 45 LFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNA 104
Query: 271 FAVTLETVLAGHENWVNAVHWQPVFYKDGVLQQPVRLLSASMDKTMILWAPDEESGVWLE 330
+ L H+++V A+ + KD L + SA +D+ + LW + + +
Sbjct: 105 HKGFCMSTLRTHKDYVKAL----AYAKDKEL-----VASAGLDRQIFLWDVNTLTALTAS 155
Query: 331 Q--VRVGEVGGNTLGFYDCQFNEDGSMIIAHAFHGALHLWKQNTVNPREWTPEIVISGHF 388
V + GN Y N+ G++I++ + L +W +PR + + GH
Sbjct: 156 NNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVW-----DPRTCAKLMKLKGHT 210
Query: 389 DGVQDLVWDPEGEFIITVGTDQTTRLFAPWKRKDQSQVTWHEIARPQIHGYDLKCLAMIN 448
D V+ L+ + +G ++ +D T RL++ +++ IA ++H + L + +
Sbjct: 211 DNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRC--------IATYRVHDEGVWALQVND 262
Query: 449 RFQFV--SGADEKV 460
F V G D K+
Sbjct: 263 AFTHVYSGGRDRKI 276
Score = 33.1 bits (74), Expect = 1.1
Identities = 45/194 (23%), Positives = 82/194 (42%), Gaps = 36/194 (18%)
Query: 31 LLAFGTSCSVVLYDPLKRVVVTNLNGHTARVNCIQWICKQDGSPSTELV-SGGSDNQVIH 89
L++ + +V +++ K ++ L H V + + + ELV S G D Q+
Sbjct: 90 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAY------AKDKELVASAGLDRQIFL 143
Query: 90 WEIE-------DNQLLKAVHLQGHEGPVYAVHAVYQRRTSDPALCTLIVSAAADSAVRLW 142
W++ N + L G++ +Y++ A+ Q L T+IVS + + +R+W
Sbjct: 144 WDVNTLTALTASNNTVTTSSLSGNKDSIYSL-AMNQ-------LGTIIVSGSTEKVLRVW 195
Query: 143 SKKGPEVMCLQTLNFGNGFALAL------CLSFLPNTDVPILACGNDDC----RIH---I 189
+ + + N AL L CLS + + + + G C R+H +
Sbjct: 196 DPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGV 255
Query: 190 FA-QQNDQFQKVLS 202
+A Q ND F V S
Sbjct: 256 WALQVNDAFTHVYS 269
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.434
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,300,722
Number of Sequences: 37866
Number of extensions: 1558763
Number of successful extensions: 4891
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 3295
Number of HSP's gapped (non-prelim): 1301
length of query: 826
length of database: 18,247,518
effective HSP length: 111
effective length of query: 715
effective length of database: 14,044,392
effective search space: 10041740280
effective search space used: 10041740280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.