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Search of human proteins with 87239981
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|87239981 tankyrase, TRF1-interacting ankyrin-related
ADP-ribose polymerase [Homo sapiens]
(1327 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 2687 0.0
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 1958 0.0
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 318 2e-86
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 315 2e-85
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 315 2e-85
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 313 5e-85
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 311 3e-84
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 311 3e-84
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 311 3e-84
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 311 3e-84
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 311 3e-84
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 246 1e-64
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 239 2e-62
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 227 7e-59
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 204 6e-52
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 203 8e-52
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 167 5e-41
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 167 6e-41
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 167 6e-41
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 161 4e-39
gi|34304381 inversin isoform a [Homo sapiens] 144 4e-34
gi|34304379 inversin isoform b [Homo sapiens] 144 4e-34
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 143 1e-33
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 143 1e-33
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 138 4e-32
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform... 135 3e-31
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 134 4e-31
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 132 2e-30
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 124 5e-28
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 122 2e-27
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 2687 bits (6966), Expect = 0.0
Identities = 1327/1327 (100%), Positives = 1327/1327 (100%)
Query: 1 MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPR 60
MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPR
Sbjct: 1 MAASRRSQHHHHHHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPR 60
Query: 61 HGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNP 120
HGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNP
Sbjct: 61 HGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNP 120
Query: 121 AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS 180
AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS
Sbjct: 121 AGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVS 180
Query: 181 GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA
Sbjct: 181 GALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
Query: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV
Sbjct: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
Query: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV
Sbjct: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL
Sbjct: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
Sbjct: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV 540
RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV
Sbjct: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV 540
Query: 541 TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL 600
TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL
Sbjct: 541 TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL 600
Query: 601 AGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKA 660
AGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKA
Sbjct: 601 AGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKA 660
Query: 661 GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP 720
GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP
Sbjct: 661 GDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVP 720
Query: 721 LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKN 780
LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKN
Sbjct: 721 LHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKN 780
Query: 781 RDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP 840
RDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP
Sbjct: 781 RDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP 840
Query: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900
LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900
Query: 901 KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA 960
KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA
Sbjct: 901 KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA 960
Query: 961 LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERK 1020
LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERK
Sbjct: 961 LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAGTERK 1020
Query: 1021 EGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLI 1080
EGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLI
Sbjct: 1021 EGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLI 1080
Query: 1081 KGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGG 1140
KGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGG
Sbjct: 1081 KGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGG 1140
Query: 1141 IFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER 1200
IFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER
Sbjct: 1141 IFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDER 1200
Query: 1201 HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF 1260
HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF
Sbjct: 1201 HAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF 1260
Query: 1261 LQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTA 1320
LQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTA
Sbjct: 1261 LQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPEAPSQTA 1320
Query: 1321 TAAEQKT 1327
TAAEQKT
Sbjct: 1321 TAAEQKT 1327
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 1958 bits (5072), Expect = 0.0
Identities = 950/1156 (82%), Positives = 1049/1156 (90%), Gaps = 9/1156 (0%)
Query: 166 GPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAG 225
G GAA AV A REL EACRNGDV RVKRLV VN++D AGRKS+PLHFAAG
Sbjct: 8 GGGAACASAAAEAVEPAARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAG 67
Query: 226 FGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTP 285
FGRKDVVE+LLQ GANV ARDDGGLIPLHNACSFGHAEVV+LLL GADPNARDNWNYTP
Sbjct: 68 FGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTP 127
Query: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
LHEAAIKGKIDVCIVLLQHGA+P IRNTDG++ALDLADPSAKAVLTGEYKKDELLE+ARS
Sbjct: 128 LHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARS 187
Query: 346 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVP 405
GNEEK+MALLTPLNVNCHASDGRKSTPLHLAAGYNRV+IVQLLLQHGADVHAKDKG LVP
Sbjct: 188 GNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVP 247
Query: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN 465
LHNACSYGHYEVTELL+KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLS+GADPTL+N
Sbjct: 248 LHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLN 307
Query: 466 CHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETA 525
CH KSA+D+APTP+L+ERL YEFKGHSLLQAAREAD+ ++KK L+LE++NFK PQ+HETA
Sbjct: 308 CHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTHETA 367
Query: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
LHCA AS +PKRKQ+ ELLLRKGAN+NEK K+F+TPLHVA+E+AHNDV+EV+ KH AK+N
Sbjct: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVN 427
Query: 586 ALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPI 645
ALD LGQT+LHRAA GHLQTCRLLLSYG DP+IISLQGFTA QMGNE VQQ+L E +
Sbjct: 428 ALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISL 487
Query: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705
S+ D +LLEA+KAGD+ETVK+LC+ Q+VNCRD+EGR STPLHFAAGYNRVSVVEYLL
Sbjct: 488 GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQ 547
Query: 706 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
HGADVHAKDKGGLVPLHNACSYGHYEVAELLV+HGA VNVADLWKFTPLHEAAAKGKYEI
Sbjct: 548 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEI 607
Query: 766 CKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP 825
CKLLL+HGADPTKKNRDGNTPLDLVK+GDTDIQDLLRGDAALLDAAKKGCLARV+KL +P
Sbjct: 608 CKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSP 667
Query: 826 ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDI 885
+N+NCRDTQGR+STPLHLAAGYNNLEVAEYLL+HGADVNAQDKGGLIPLHNAASYGHVD+
Sbjct: 668 DNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDV 727
Query: 886 AALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
AALLIKYN CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT+KNQEGQTPLDL +A
Sbjct: 728 AALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSA 787
Query: 946 DDIRALLIDAMPPEALPTCFKPQAT-------VVSASLISPASTPSCLSAASSIDNLTGP 998
DD+ ALL AMPP ALP+C+KPQ + +L S S+PS LSAASS+DNL+G
Sbjct: 788 DDVSALLTAAMPPSALPSCYKPQVLNGVRSPGATADALSSGPSSPSSLSAASSLDNLSGS 847
Query: 999 LAELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLA 1058
+EL+ +S+ +GA+ E+K EV G+D +I+QF+++LGLEHL DIFE EQITLDVL
Sbjct: 848 FSELSSVVSSSGTEGASSLEKK--EVPGVDFSITQFVRNLGLEHLMDIFEREQITLDVLV 905
Query: 1059 DMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEY 1118
+MGH+ELKEIGINAYGHRHKLIKGVERL+ GQQG NPYLT + GTIL+DL+P+DKE+
Sbjct: 906 EMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNTSGSGTILIDLSPDDKEF 965
Query: 1119 QSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHN 1178
QSVEEEMQST+REHRDGG+AGGIFNRYN+++IQKV NKKL ER+ HR+KEVSEENHNH N
Sbjct: 966 QSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHAN 1025
Query: 1179 ERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHK 1238
ERMLFHGSPF+NAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCP HK
Sbjct: 1026 ERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHK 1085
Query: 1239 DRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGE 1298
DRSCYICHRQ+LFCRVTLGKSFLQFS MKMAH+PPGHHSV GRPSVNGLA AEYVIYRGE
Sbjct: 1086 DRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGE 1145
Query: 1299 QAYPEYLITYQIMKPE 1314
QAYPEYLITYQIM+PE
Sbjct: 1146 QAYPEYLITYQIMRPE 1161
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 318 bits (816), Expect = 2e-86
Identities = 256/794 (32%), Positives = 370/794 (46%), Gaps = 59/794 (7%)
Query: 180 SGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQM 238
S A L A R G + + + + ++N + G + LH A+ G +VV LLQ
Sbjct: 39 SDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVVSELLQR 96
Query: 239 GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVC 298
ANV A G LH A G AEVV +L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 97 EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
Query: 299 IVLLQHGADPNIRNTDGKSALDLA-----DPSAKAVLTGEYKKDELLEA---ARSGNEEK 350
LL +GA ++ DG + L +A D +L + K L A A ++ K
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTK 216
Query: 351 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC 410
ALL + N TPLH+AA Y + + LLL A V + + PLH A
Sbjct: 217 AAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVAS 276
Query: 411 SYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
G+ + +LLL GA ++A TPLH A +V +LL A +G S
Sbjct: 277 KRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLS 336
Query: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
+ MA + + LLQ D ++ N + TALH A
Sbjct: 337 PLHMATQGDHLNCVQL------LLQHNVPVD----------DVTN-----DYLTALHVAA 375
Query: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
H K V ++LL K AN N K + TPLH+A ++ VME+L KHGA + A+
Sbjct: 376 HCGHYK---VAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTES 432
Query: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGN-----EAVQQILSESTPI 645
G T +H AA GH+ L+ +G+ P+ +++G TA M E V+ ++ + +
Sbjct: 433 GLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 646 --RTSDVDYRLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEY 702
+ D L +++ G + V+QL + N G TPLH +A V +
Sbjct: 493 EAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY--TPLHLSAREGHEDVAAF 550
Query: 703 LLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGK 762
LL HGA + K G PLH A YG EVA LL++ AS + A TPLH AA
Sbjct: 551 LLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDN 610
Query: 763 YEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLL------------RGDAALLD 809
++ LLL GA P ++G TPL + K+ DI L +G A++
Sbjct: 611 QKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHL 670
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
AA++G + V L N N + TPLHLAA + + VAE L+ GA V+AQ K
Sbjct: 671 AAQEGHVDMVS-LLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM 729
Query: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
G PLH YG++ I L++++ VNA K +TPLH+AAQ+G T + +LL + A P
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 930 TMKNQEGQTPLDLA 943
G T L +A
Sbjct: 790 NELTVNGNTALGIA 803
Score = 265 bits (677), Expect = 2e-70
Identities = 221/676 (32%), Positives = 315/676 (46%), Gaps = 81/676 (11%)
Query: 340 LEAARSGNEEKLMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
L AAR+G+ EK + + +++N +G + LHLA+ V +V LLQ A+V A
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVVSELLQREANVDAA 103
Query: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
K G LH A G EV ++L+ +GA VNA FTPL+ AA +N +EV LL +G
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Query: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514
A +L G + A+ + L + KG L A A K AL +
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 515 NFK----QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH 570
N + +S T LH A H V LLL + A V+ ++ +TPLHVA++R +
Sbjct: 224 NDNNADVESKSGFTPLHIAA---HYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGN 280
Query: 571 NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM 630
+++++L GAK++A G T LH A +GH Q +LL + + G + M
Sbjct: 281 ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHM 340
Query: 631 GNEA-----VQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-NVNCRDLEG 682
+ VQ +L + P+ DY L A+ G + K L + N N + L G
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNG 400
Query: 683 RHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGAS 742
TPLH A NR+ V+E LL HGA + A + GL P+H A GH + L+ HGAS
Sbjct: 401 --FTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS 458
Query: 743 VNV-----------------ADLWKF----------------TPLHEAAAKGKYEICKLL 769
N A++ ++ TPLH +A GK +I + L
Sbjct: 459 PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQL 518
Query: 770 LKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLD------------AAKKGCL 816
L+ GA P G TPL L +EG D+ L A L AAK G L
Sbjct: 519 LQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKL 578
Query: 817 A----RVQKLCTPENINCRDTQGRNS-TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGL 871
+QK +P D G++ TPLH+AA Y+N +VA LL+ GA +A K G
Sbjct: 579 EVANLLLQKSASP------DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGY 632
Query: 872 IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM 931
PLH AA +DIA L++Y NA + +H AAQ+G + +LLL A+ +
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692
Query: 932 KNQEGQTPLDLATADD 947
N+ G TPL LA +D
Sbjct: 693 SNKSGLTPLHLAAQED 708
Score = 242 bits (617), Expect = 2e-63
Identities = 210/724 (29%), Positives = 306/724 (42%), Gaps = 98/724 (13%)
Query: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKS-SPLHFAAGFGRKDVVEHLLQMGANVHARDD 247
A R D L+ N N D+ + +PLH AA +G +V LL A V
Sbjct: 209 AARKDDTKAAALLLQ--NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTAR 266
Query: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307
+ PLH A G+A +V LLL +GA +A+ TPLH A G V +LL A
Sbjct: 267 NDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP 326
Query: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367
+ +G S L +A G+ + LL NV
Sbjct: 327 ILSKTKNGLSPLHMAT---------------------QGDHLNCVQLLLQHNVPVDDVTN 365
Query: 368 RKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGAC 427
T LH+AA ++ ++LL A+ +AK G PLH AC +V ELLLKHGA
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Query: 428 VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYE 487
+ A+ TP+H AA V + S L+ HGA P N G++A+ MA E + Y
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 488 FKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK 547
+ + ++A + D +T LH S + + + LL++
Sbjct: 486 VQDGAQVEAKAKDD---------------------QTPLHI---SARLGKADIVQQLLQQ 521
Query: 548 GANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTC 607
GA+ N TPLH++A H DV L HGA ++ G T LH AA G L+
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 608 RLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSES------------TPIRTS--- 648
LLL + P G T AA N+ V +L + TP+ +
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK 641
Query: 649 ---DVDYRLLE------------------ASKAGDLETVKQLCS-SQNVNCRDLEGRHST 686
D+ LLE A++ G ++ V L + NVN + G T
Sbjct: 642 NQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL--T 699
Query: 687 PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVA 746
PLH AA +RV+V E L++ GA V A+ K G PLH C YG+ ++ L++H A VN
Sbjct: 700 PLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAK 759
Query: 747 DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLRGDA 805
+TPLH+AA +G I +LL++ A P + +GNT L + + G + D L+
Sbjct: 760 TKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLK--I 817
Query: 806 ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYL--LEHGADV 863
+ + K+ PE +N + + + A L EY+ +E G D
Sbjct: 818 VTEETMTTTTVTEKHKMNVPETMN--EVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDA 875
Query: 864 NAQD 867
D
Sbjct: 876 MTGD 879
Score = 148 bits (374), Expect = 3e-35
Identities = 127/466 (27%), Positives = 199/466 (42%), Gaps = 51/466 (10%)
Query: 546 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQ 605
RK + +K D AA H + K+G +N + G ALH A+ GH++
Sbjct: 29 RKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVE 88
Query: 606 TCRLLLSYGSDPSIISLQGFTAAQMGN-----EAVQQILSESTPIRTSDVD--YRLLEAS 658
LL ++ + +G TA + + E V+ +++ + + L A+
Sbjct: 89 VVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAA 148
Query: 659 KAGDLETVKQLC---SSQNVNC------------------------RDLEGRHSTP-LHF 690
+ LE VK L +SQ++ D +G+ P LH
Sbjct: 149 QENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHI 208
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA + LL + + + K G PLH A YG+ VA LL+ A+V+
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAALLD 809
TPLH A+ +G + KLLL GA K RDG TPL + G + ++L AA +
Sbjct: 269 ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPIL 328
Query: 810 AAKKGCLARVQKLCTPENINC-----------RDTQGRNSTPLHLAAGYNNLEVAEYLLE 858
+ K L+ + +++NC D T LH+AA + +VA+ LL+
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
Query: 859 HGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQL 918
A+ NA+ G PLH A + + LL+K+ + A + TP+H AA G +
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 919 CALLLAHGADPTMKNQEGQTPLDLAT----ADDIRALLIDAMPPEA 960
+ L+ HGA P N G+T L +A A+ +R L+ D EA
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEA 494
Score = 30.8 bits (68), Expect = 9.0
Identities = 46/200 (23%), Positives = 78/200 (39%), Gaps = 14/200 (7%)
Query: 37 PGL---APGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTT 93
PG+ + G T + PT PF S R P + P P P TS S++
Sbjct: 1475 PGMIERSTGATRSLPTTYSYKPFFSTR-----PYQSWTTAPITVP-GPAKSGFTSLSSSS 1528
Query: 94 STICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAES 153
S + + + +VST S + + S S S +SP S + S + +++S
Sbjct: 1529 SNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTMSSPIKTVVSQS 1588
Query: 154 PEAAGVSSTAPLGPGAAGPG-TGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNAKDM 212
P VSS G A P T + G + R V+ L++ +++
Sbjct: 1589 PYNIQVSS----GTLARAPAVTEATPLKGLASNSTFSSRTSPVTTAGSLLERSSITMTPP 1644
Query: 213 AGRKSSPLHFAAGFGRKDVV 232
A KS+ +++ K ++
Sbjct: 1645 ASPKSNINMYSSSLPFKSII 1664
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 315 bits (807), Expect = 2e-85
Identities = 269/826 (32%), Positives = 378/826 (45%), Gaps = 109/826 (13%)
Query: 177 PAVSGALRELLEACRNGDVSRV-KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHL 235
P S + L A R G++ +V + L ++N + G + LH AA G +V+ L
Sbjct: 26 PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQEL 83
Query: 236 LQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295
L G++V + G LH A G AEVV +L+ +GA+ NA+ +TPL+ AA + I
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 296 DVCIVLLQHGADPNIRNTDGKS----ALDLADPSAKAVL-----TGEYKKDELLEAARSG 346
DV LL++GA+ + DG + AL A A+L G+ + L AAR
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 347 NEEKLMALL---------TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
+ + LL + + VN G TPLH+AA Y V + LLL GA V
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDF 261
Query: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
+ G+ PLH A G+ + +LLL G ++A TPLH AA +V LLL
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 458 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK 517
GA +G S + MA + E + + LLQ D + L+ +
Sbjct: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKH------LLQHKAPVD------DVTLDYL--- 366
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
TALH A H +VT+LLL K AN N + + TPLH+A ++ VME+L
Sbjct: 367 ------TALHVAA---HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
K+GA + A+ G T +H AA GHL LLL G+ P + +++G TA M A Q
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 638 ILSESTPIRTSDVDYRLLE-------ASKAGDLETVKQLCSSQ--------------NVN 676
+ + VD R E AS+ G E V+ L +++
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 677 CRDLE-----------GRHS-------TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
R+ + HS TPLH AA Y + V + LL A + K GL
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 719 VPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTK 778
PLH A Y + +VA LL+ GAS + +TPLH AA K + +I LL +GA+
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 779 KNRDGNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRN 837
+ G TPL L +EG TD+ LL A + + K L
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL--------------------- 696
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
T LHLAA + + VA+ L +HGAD +A K G PL A YG+V + L+K VN
Sbjct: 697 -TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
A K +TPLH+AAQ+G T + +LL HGA P G T L +A
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 278 bits (710), Expect = 3e-74
Identities = 219/662 (33%), Positives = 329/662 (49%), Gaps = 61/662 (9%)
Query: 340 LEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
L AAR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
K G LH A G EV ++L+K GA +NA FTPL+ AA +N ++V LL +G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514
A+ + G + A+ + L + KG L A A K+ AL +
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 515 NF------------KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
N + +S T LH A H V LLL +GA V+ ++ +TPL
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPL 270
Query: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622
HVA++R + +++++L G +++A G T LH AA +GH Q LLL G+ +
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 623 QGFTAAQMGN-----EAVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-N 674
G + M E V+ +L P+ +DY L A+ G K L + N
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 675 VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAE 734
N R L G TPLH A NR+ V+E L+ +GA + A + GL P+H A GH +
Sbjct: 391 PNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-G 793
LL+++GAS +V ++ T LH AA G+ E+ + LL++GA + R+ TPL + G
Sbjct: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
Query: 794 DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQ------------------G 835
T+I LL A DAA TP +I+ R+ Q
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGY-------TPLHISAREGQVDVASVLLEAGAAHSLATK 561
Query: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
+ TPLH+AA Y +L+VA+ LL+ A ++ K GL PLH AA Y + +A LL++
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALL 952
+AT K +TPLH AA+K + Q+ + LL +GA+ + ++G TPL LA+ + D+ LL
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 953 ID 954
+D
Sbjct: 682 LD 683
Score = 260 bits (664), Expect = 7e-69
Identities = 234/780 (30%), Positives = 336/780 (43%), Gaps = 140/780 (17%)
Query: 193 GDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
G VK LV + AN+NA+ G +PL+ AA DVV++LL+ GAN + G
Sbjct: 108 GQAEVVKVLVKEGANINAQSQNG--FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 165
Query: 252 PLHNACSFGHAEVVSLLL-------------------------------CQGADPNARDN 280
PL A GH + V++LL AD ++
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 225
Query: 281 WN------YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT--- 331
N +TPLH AA G ++V +LL GA + +G + L +A +
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 332 -------GEYKKDELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR 381
+D L AARSG+++ ++ LL A +PLH+AA +
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Query: 382 VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHE 441
V V+ LLQH A V L LH A GHY VT+LLL A NA L FTPLH
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Query: 442 AASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQA 496
A KNR++V LL+ +GA + G + + +A F GH LLQ
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVA-----------AFMGHLNIVLLLLQN 453
Query: 497 AREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNK 556
D+ ++ ETALH A + + +V LLR GA V+ + +
Sbjct: 454 GASPDVTNIR---------------GETALHMAARA---GQVEVVRCLLRNGALVDARAR 495
Query: 557 DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
+ TPLH+A+ +++++L +H A +A T G T LH +A G + +LL G+
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 617 PSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVN 676
S+ + +GFT + A+K G L+ K L Q
Sbjct: 556 HSLATKKGFTPLHV--------------------------AAKYGSLDVAKLLL--QRRA 587
Query: 677 CRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
D G++ TPLH AA Y+ V LL GA HA K G PLH A ++A
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD- 794
L+ +GA N+ TPLH A+ +G ++ LLL GA+ + G T L L + D
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707
Query: 795 TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAE 854
++ D+L A DA K TPL +A Y N+++
Sbjct: 708 VNVADILTKHGADQDAHTK----------------------LGYTPLIVACHYGNVKMVN 745
Query: 855 YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG 914
+LL+ GA+VNA+ K G PLH AA GH I +L+++ NAT T L A + G
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 236 bits (602), Expect = 1e-61
Identities = 197/632 (31%), Positives = 287/632 (45%), Gaps = 69/632 (10%)
Query: 205 ANVNAKDMAGRKS----SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFG 260
A+V +K M R + +PLH AA +G +V LL GA V G+ PLH A G
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 261 HAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALD 320
+ +V LLL +G +A+ TPLH AA G V +LL+ GA R +G S L
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 337
Query: 321 LADPS-----AKAVLTGEYKKDEL-------LEAARSGNEEKLMALLTPLNVNCHASDGR 368
+A K +L + D++ L A ++ LL N +A
Sbjct: 338 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397
Query: 369 KSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACV 428
TPLH+A NR+++++LL+++GA + A + GL P+H A GH + LLL++GA
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 429 NAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP-ELRERLTYE 487
+ ++ T LH AA +VEV LL +GA LV+ + TP + RL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGA---LVDARAREE----QTPLHIASRLGKT 510
Query: 488 FKGHSLLQAAREADLAKVKKTLALEI-----------INFKQPQSHETALHCAVASLHPK 536
LLQ D A L I + + +H A LH
Sbjct: 511 EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Query: 537 RK----QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
K V +LLL++ A + K+ +TPLHVAA + V +L + GA +A G
Sbjct: 571 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
T LH AA +Q LL+YG++ +I++ QG T +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL---------------------- 668
Query: 653 RLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
AS+ G + V L N++ G T LH AA ++V+V + L HGAD
Sbjct: 669 ----ASQEGHTDMVTLLLDKGANIHMSTKSGL--TSLHLAAQEDKVNVADILTKHGADQD 722
Query: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
A K G PL AC YG+ ++ L++ GA+VN +TPLH+AA +G I +LL+
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Query: 772 HGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
HGA P +GNT L + K G + D L+
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 182 bits (461), Expect = 2e-45
Identities = 143/447 (31%), Positives = 217/447 (48%), Gaps = 30/447 (6%)
Query: 183 LRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
L L A G K L+D AN NA+ + G +PLH A R V+E L++ GA+
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNG--FTPLHIACKKNRIKVMELLVKYGAS 423
Query: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
+ A + GL P+H A GH +V LLL GA P+ + T LH AA G+++V L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 302 LQHGADPNIRNTDGKSALDLADPSAK---------------AVLTGEYKKDELLEAARSG 346
L++GA + R + ++ L +A K A T Y L +AR G
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY--TPLHISAREG 541
Query: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
+ LL + A+ + TPLH+AA Y + + +LLLQ A + K GL PL
Sbjct: 542 QVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466
H A Y + +V LLL+ GA +A +TPLH AA KN++++ S LL++GA+ +V
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKV-------KKTLALEIINFKQP 519
G + + +A + +T + + + ++ L + K +A +
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Query: 520 QSHETALHCA--VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
Q T L + + H ++ LL++GANVN K K+ TPLH AA++ H ++ VL
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHL 604
+HGAK NA G TAL A G++
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYI 807
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 315 bits (807), Expect = 2e-85
Identities = 269/826 (32%), Positives = 378/826 (45%), Gaps = 109/826 (13%)
Query: 177 PAVSGALRELLEACRNGDVSRV-KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHL 235
P S + L A R G++ +V + L ++N + G + LH AA G +V+ L
Sbjct: 26 PKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQEL 83
Query: 236 LQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295
L G++V + G LH A G AEVV +L+ +GA+ NA+ +TPL+ AA + I
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 296 DVCIVLLQHGADPNIRNTDGKS----ALDLADPSAKAVL-----TGEYKKDELLEAARSG 346
DV LL++GA+ + DG + AL A A+L G+ + L AAR
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 347 NEEKLMALL---------TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
+ + LL + + VN G TPLH+AA Y V + LLL GA V
Sbjct: 204 DTKSAALLLQNDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDF 261
Query: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
+ G+ PLH A G+ + +LLL G ++A TPLH AA +V LLL
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321
Query: 458 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFK 517
GA +G S + MA + E + + LLQ D + L+ +
Sbjct: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKH------LLQHKAPVD------DVTLDYL--- 366
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
TALH A H +VT+LLL K AN N + + TPLH+A ++ VME+L
Sbjct: 367 ------TALHVAA---HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELL 417
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
K+GA + A+ G T +H AA GHL LLL G+ P + +++G TA M A Q
Sbjct: 418 VKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQV 477
Query: 638 ILSESTPIRTSDVDYRLLE-------ASKAGDLETVKQLCSSQ--------------NVN 676
+ + VD R E AS+ G E V+ L +++
Sbjct: 478 EVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHIS 537
Query: 677 CRDLE-----------GRHS-------TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
R+ + HS TPLH AA Y + V + LL A + K GL
Sbjct: 538 AREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGL 597
Query: 719 VPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTK 778
PLH A Y + +VA LL+ GAS + +TPLH AA K + +I LL +GA+
Sbjct: 598 TPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI 657
Query: 779 KNRDGNTPLDLV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRN 837
+ G TPL L +EG TD+ LL A + + K L
Sbjct: 658 VTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL--------------------- 696
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
T LHLAA + + VA+ L +HGAD +A K G PL A YG+V + L+K VN
Sbjct: 697 -TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVN 755
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
A K +TPLH+AAQ+G T + +LL HGA P G T L +A
Sbjct: 756 AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 801
Score = 278 bits (710), Expect = 3e-74
Identities = 219/662 (33%), Positives = 329/662 (49%), Gaps = 61/662 (9%)
Query: 340 LEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
L AAR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 93
Query: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
K G LH A G EV ++L+K GA +NA FTPL+ AA +N ++V LL +G
Sbjct: 94 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 153
Query: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514
A+ + G + A+ + L + KG L A A K+ AL +
Sbjct: 154 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 213
Query: 515 NF------------KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
N + +S T LH A H V LLL +GA V+ ++ +TPL
Sbjct: 214 NDHNADVQSKMMVNRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPL 270
Query: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622
HVA++R + +++++L G +++A G T LH AA +GH Q LLL G+ +
Sbjct: 271 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 330
Query: 623 QGFTAAQMGN-----EAVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-N 674
G + M E V+ +L P+ +DY L A+ G K L + N
Sbjct: 331 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 390
Query: 675 VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAE 734
N R L G TPLH A NR+ V+E L+ +GA + A + GL P+H A GH +
Sbjct: 391 PNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-G 793
LL+++GAS +V ++ T LH AA G+ E+ + LL++GA + R+ TPL + G
Sbjct: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
Query: 794 DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQ------------------G 835
T+I LL A DAA TP +I+ R+ Q
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGY-------TPLHISAREGQVDVASVLLEAGAAHSLATK 561
Query: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
+ TPLH+AA Y +L+VA+ LL+ A ++ K GL PLH AA Y + +A LL++
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALL 952
+AT K +TPLH AA+K + Q+ + LL +GA+ + ++G TPL LA+ + D+ LL
Sbjct: 622 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Query: 953 ID 954
+D
Sbjct: 682 LD 683
Score = 260 bits (664), Expect = 7e-69
Identities = 234/780 (30%), Positives = 336/780 (43%), Gaps = 140/780 (17%)
Query: 193 GDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
G VK LV + AN+NA+ G +PL+ AA DVV++LL+ GAN + G
Sbjct: 108 GQAEVVKVLVKEGANINAQSQNG--FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 165
Query: 252 PLHNACSFGHAEVVSLLL-------------------------------CQGADPNARDN 280
PL A GH + V++LL AD ++
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 225
Query: 281 WN------YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT--- 331
N +TPLH AA G ++V +LL GA + +G + L +A +
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285
Query: 332 -------GEYKKDELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR 381
+D L AARSG+++ ++ LL A +PLH+AA +
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQGDH 344
Query: 382 VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHE 441
V V+ LLQH A V L LH A GHY VT+LLL A NA L FTPLH
Sbjct: 345 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Query: 442 AASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQA 496
A KNR++V LL+ +GA + G + + +A F GH LLQ
Sbjct: 405 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVA-----------AFMGHLNIVLLLLQN 453
Query: 497 AREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNK 556
D+ ++ ETALH A + + +V LLR GA V+ + +
Sbjct: 454 GASPDVTNIR---------------GETALHMAARA---GQVEVVRCLLRNGALVDARAR 495
Query: 557 DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
+ TPLH+A+ +++++L +H A +A T G T LH +A G + +LL G+
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 555
Query: 617 PSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVN 676
S+ + +GFT + A+K G L+ K L Q
Sbjct: 556 HSLATKKGFTPLHV--------------------------AAKYGSLDVAKLLL--QRRA 587
Query: 677 CRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
D G++ TPLH AA Y+ V LL GA HA K G PLH A ++A
Sbjct: 588 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 647
Query: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD- 794
L+ +GA N+ TPLH A+ +G ++ LLL GA+ + G T L L + D
Sbjct: 648 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 707
Query: 795 TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAE 854
++ D+L A DA K TPL +A Y N+++
Sbjct: 708 VNVADILTKHGADQDAHTK----------------------LGYTPLIVACHYGNVKMVN 745
Query: 855 YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG 914
+LL+ GA+VNA+ K G PLH AA GH I +L+++ NAT T L A + G
Sbjct: 746 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 805
Score = 236 bits (602), Expect = 1e-61
Identities = 197/632 (31%), Positives = 287/632 (45%), Gaps = 69/632 (10%)
Query: 205 ANVNAKDMAGRKS----SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFG 260
A+V +K M R + +PLH AA +G +V LL GA V G+ PLH A G
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 277
Query: 261 HAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALD 320
+ +V LLL +G +A+ TPLH AA G V +LL+ GA R +G S L
Sbjct: 278 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 337
Query: 321 LADPS-----AKAVLTGEYKKDEL-------LEAARSGNEEKLMALLTPLNVNCHASDGR 368
+A K +L + D++ L A ++ LL N +A
Sbjct: 338 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 397
Query: 369 KSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACV 428
TPLH+A NR+++++LL+++GA + A + GL P+H A GH + LLL++GA
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 429 NAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP-ELRERLTYE 487
+ ++ T LH AA +VEV LL +GA LV+ + TP + RL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGA---LVDARAREE----QTPLHIASRLGKT 510
Query: 488 FKGHSLLQAAREADLAKVKKTLALEI-----------INFKQPQSHETALHCAVASLHPK 536
LLQ D A L I + + +H A LH
Sbjct: 511 EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570
Query: 537 RK----QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
K V +LLL++ A + K+ +TPLHVAA + V +L + GA +A G
Sbjct: 571 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 630
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
T LH AA +Q LL+YG++ +I++ QG T +
Sbjct: 631 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL---------------------- 668
Query: 653 RLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
AS+ G + V L N++ G T LH AA ++V+V + L HGAD
Sbjct: 669 ----ASQEGHTDMVTLLLDKGANIHMSTKSGL--TSLHLAAQEDKVNVADILTKHGADQD 722
Query: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
A K G PL AC YG+ ++ L++ GA+VN +TPLH+AA +G I +LL+
Sbjct: 723 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 782
Query: 772 HGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
HGA P +GNT L + K G + D L+
Sbjct: 783 HGAKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 182 bits (461), Expect = 2e-45
Identities = 143/447 (31%), Positives = 217/447 (48%), Gaps = 30/447 (6%)
Query: 183 LRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
L L A G K L+D AN NA+ + G +PLH A R V+E L++ GA+
Sbjct: 366 LTALHVAAHCGHYRVTKLLLDKRANPNARALNG--FTPLHIACKKNRIKVMELLVKYGAS 423
Query: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
+ A + GL P+H A GH +V LLL GA P+ + T LH AA G+++V L
Sbjct: 424 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 483
Query: 302 LQHGADPNIRNTDGKSALDLADPSAK---------------AVLTGEYKKDELLEAARSG 346
L++GA + R + ++ L +A K A T Y L +AR G
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY--TPLHISAREG 541
Query: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
+ LL + A+ + TPLH+AA Y + + +LLLQ A + K GL PL
Sbjct: 542 QVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 600
Query: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466
H A Y + +V LLL+ GA +A +TPLH AA KN++++ S LL++GA+ +V
Sbjct: 601 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 660
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKV-------KKTLALEIINFKQP 519
G + + +A + +T + + + ++ L + K +A +
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Query: 520 QSHETALHCA--VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
Q T L + + H ++ LL++GANVN K K+ TPLH AA++ H ++ VL
Sbjct: 721 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHL 604
+HGAK NA G TAL A G++
Sbjct: 781 LQHGAKPNATTANGNTALAIAKRLGYI 807
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 313 bits (803), Expect = 5e-85
Identities = 267/816 (32%), Positives = 375/816 (45%), Gaps = 109/816 (13%)
Query: 187 LEACRNGDVSRV-KRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
L A R G++ +V + L ++N + G + LH AA G +V+ LL G++V +
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
G LH A G AEVV +L+ +GA+ NA+ +TPL+ AA + IDV LL++G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 306 ADPNIRNTDGKS----ALDLADPSAKAVL-----TGEYKKDELLEAARSGNEEKLMALL- 355
A+ + DG + AL A A+L G+ + L AAR + + LL
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 356 --------TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 407
+ + VN G TPLH+AA Y V + LLL GA V + G+ PLH
Sbjct: 193 NDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLH 250
Query: 408 NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCH 467
A G+ + +LLL G ++A TPLH AA +V LLL GA +
Sbjct: 251 VASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
Query: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
G S + MA + E + + LLQ D + L+ + TALH
Sbjct: 311 GLSPLHMAAQGDHVECVKH------LLQHKAPVD------DVTLDYL---------TALH 349
Query: 528 CAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL 587
A H +VT+LLL K AN N + + TPLH+A ++ VME+L K+GA + A+
Sbjct: 350 VAA---HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAI 406
Query: 588 DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRT 647
G T +H AA GHL LLL G+ P + +++G TA M A Q +
Sbjct: 407 TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
Query: 648 SDVDYRLLE-------ASKAGDLETVKQLCSSQ--------------NVNCRDLE----- 681
+ VD R E AS+ G E V+ L +++ R+ +
Sbjct: 467 ALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVAS 526
Query: 682 ------GRHS-------TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYG 728
HS TPLH AA Y + V + LL A + K GL PLH A Y
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586
Query: 729 HYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD 788
+ +VA LL+ GAS + +TPLH AA K + +I LL +GA+ + G TPL
Sbjct: 587 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLH 646
Query: 789 LV-KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847
L +EG TD+ LL A + + K L T LHLAA
Sbjct: 647 LASQEGHTDMVTLLLDKGANIHMSTKSGL----------------------TSLHLAAQE 684
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
+ + VA+ L +HGAD +A K G PL A YG+V + L+K VNA K +TPL
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Query: 908 HEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
H+AAQ+G T + +LL HGA P G T L +A
Sbjct: 745 HQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIA 780
Score = 278 bits (710), Expect = 3e-74
Identities = 219/662 (33%), Positives = 329/662 (49%), Gaps = 61/662 (9%)
Query: 340 LEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
L AAR+GN +K++ L +++N +G + LHLAA V +VQ LL G+ V +
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNA--LHLAAKEGHVGLVQELLGRGSSVDSA 72
Query: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
K G LH A G EV ++L+K GA +NA FTPL+ AA +N ++V LL +G
Sbjct: 73 TKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENG 132
Query: 459 ADPTLVNCHGKS----AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEII 514
A+ + G + A+ + L + KG L A A K+ AL +
Sbjct: 133 ANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQ 192
Query: 515 NF------------KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
N + +S T LH A H V LLL +GA V+ ++ +TPL
Sbjct: 193 NDHNADVQSKMMVNRTTESGFTPLHIAA---HYGNVNVATLLLNRGAAVDFTARNGITPL 249
Query: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622
HVA++R + +++++L G +++A G T LH AA +GH Q LLL G+ +
Sbjct: 250 HVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTK 309
Query: 623 QGFTAAQMGN-----EAVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-N 674
G + M E V+ +L P+ +DY L A+ G K L + N
Sbjct: 310 NGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRAN 369
Query: 675 VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAE 734
N R L G TPLH A NR+ V+E L+ +GA + A + GL P+H A GH +
Sbjct: 370 PNARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
Query: 735 LLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-G 793
LL+++GAS +V ++ T LH AA G+ E+ + LL++GA + R+ TPL + G
Sbjct: 428 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 487
Query: 794 DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQ------------------G 835
T+I LL A DAA TP +I+ R+ Q
Sbjct: 488 KTEIVQLLLQHMAHPDAATTNGY-------TPLHISAREGQVDVASVLLEAGAAHSLATK 540
Query: 836 RNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895
+ TPLH+AA Y +L+VA+ LL+ A ++ K GL PLH AA Y + +A LL++
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALL 952
+AT K +TPLH AA+K + Q+ + LL +GA+ + ++G TPL LA+ + D+ LL
Sbjct: 601 PHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Query: 953 ID 954
+D
Sbjct: 661 LD 662
Score = 260 bits (664), Expect = 7e-69
Identities = 234/780 (30%), Positives = 336/780 (43%), Gaps = 140/780 (17%)
Query: 193 GDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
G VK LV + AN+NA+ G +PL+ AA DVV++LL+ GAN + G
Sbjct: 87 GQAEVVKVLVKEGANINAQSQNG--FTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 144
Query: 252 PLHNACSFGHAEVVSLLL-------------------------------CQGADPNARDN 280
PL A GH + V++LL AD ++
Sbjct: 145 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 204
Query: 281 WN------YTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT--- 331
N +TPLH AA G ++V +LL GA + +G + L +A +
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264
Query: 332 -------GEYKKDELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR 381
+D L AARSG+++ ++ LL A +PLH+AA +
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQ-VVELLLERGAPLLARTKNGLSPLHMAAQGDH 323
Query: 382 VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHE 441
V V+ LLQH A V L LH A GHY VT+LLL A NA L FTPLH
Sbjct: 324 VECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383
Query: 442 AASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQA 496
A KNR++V LL+ +GA + G + + +A F GH LLQ
Sbjct: 384 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVA-----------AFMGHLNIVLLLLQN 432
Query: 497 AREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNK 556
D+ ++ ETALH A + + +V LLR GA V+ + +
Sbjct: 433 GASPDVTNIR---------------GETALHMAARA---GQVEVVRCLLRNGALVDARAR 474
Query: 557 DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
+ TPLH+A+ +++++L +H A +A T G T LH +A G + +LL G+
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAA 534
Query: 617 PSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVN 676
S+ + +GFT + A+K G L+ K L Q
Sbjct: 535 HSLATKKGFTPLHV--------------------------AAKYGSLDVAKLLL--QRRA 566
Query: 677 CRDLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 735
D G++ TPLH AA Y+ V LL GA HA K G PLH A ++A
Sbjct: 567 AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIAST 626
Query: 736 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD- 794
L+ +GA N+ TPLH A+ +G ++ LLL GA+ + G T L L + D
Sbjct: 627 LLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDK 686
Query: 795 TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAE 854
++ D+L A DA K TPL +A Y N+++
Sbjct: 687 VNVADILTKHGADQDAHTK----------------------LGYTPLIVACHYGNVKMVN 724
Query: 855 YLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKG 914
+LL+ GA+VNA+ K G PLH AA GH I +L+++ NAT T L A + G
Sbjct: 725 FLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLG 784
Score = 236 bits (602), Expect = 1e-61
Identities = 197/632 (31%), Positives = 287/632 (45%), Gaps = 69/632 (10%)
Query: 205 ANVNAKDMAGRKS----SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFG 260
A+V +K M R + +PLH AA +G +V LL GA V G+ PLH A G
Sbjct: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRG 256
Query: 261 HAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALD 320
+ +V LLL +G +A+ TPLH AA G V +LL+ GA R +G S L
Sbjct: 257 NTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLH 316
Query: 321 LADPS-----AKAVLTGEYKKDEL-------LEAARSGNEEKLMALLTPLNVNCHASDGR 368
+A K +L + D++ L A ++ LL N +A
Sbjct: 317 MAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALN 376
Query: 369 KSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACV 428
TPLH+A NR+++++LL+++GA + A + GL P+H A GH + LLL++GA
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 429 NAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP-ELRERLTYE 487
+ ++ T LH AA +VEV LL +GA LV+ + TP + RL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGA---LVDARAREE----QTPLHIASRLGKT 489
Query: 488 FKGHSLLQAAREADLAKVKKTLALEI-----------INFKQPQSHETALHCAVASLHPK 536
LLQ D A L I + + +H A LH
Sbjct: 490 EIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549
Query: 537 RK----QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
K V +LLL++ A + K+ +TPLHVAA + V +L + GA +A G
Sbjct: 550 AKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY 609
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
T LH AA +Q LL+YG++ +I++ QG T +
Sbjct: 610 TPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHL---------------------- 647
Query: 653 RLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
AS+ G + V L N++ G T LH AA ++V+V + L HGAD
Sbjct: 648 ----ASQEGHTDMVTLLLDKGANIHMSTKSGL--TSLHLAAQEDKVNVADILTKHGADQD 701
Query: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
A K G PL AC YG+ ++ L++ GA+VN +TPLH+AA +G I +LL+
Sbjct: 702 AHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQ 761
Query: 772 HGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
HGA P +GNT L + K G + D L+
Sbjct: 762 HGAKPNATTANGNTALAIAKRLGYISVVDTLK 793
Score = 182 bits (461), Expect = 2e-45
Identities = 143/447 (31%), Positives = 217/447 (48%), Gaps = 30/447 (6%)
Query: 183 LRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
L L A G K L+D AN NA+ + G +PLH A R V+E L++ GA+
Sbjct: 345 LTALHVAAHCGHYRVTKLLLDKRANPNARALNG--FTPLHIACKKNRIKVMELLVKYGAS 402
Query: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
+ A + GL P+H A GH +V LLL GA P+ + T LH AA G+++V L
Sbjct: 403 IQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCL 462
Query: 302 LQHGADPNIRNTDGKSALDLADPSAK---------------AVLTGEYKKDELLEAARSG 346
L++GA + R + ++ L +A K A T Y L +AR G
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGY--TPLHISAREG 520
Query: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
+ LL + A+ + TPLH+AA Y + + +LLLQ A + K GL PL
Sbjct: 521 QVDVASVLLEAGAAHSLATK-KGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPL 579
Query: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466
H A Y + +V LLL+ GA +A +TPLH AA KN++++ S LL++GA+ +V
Sbjct: 580 HVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK 639
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKV-------KKTLALEIINFKQP 519
G + + +A + +T + + + ++ L + K +A +
Sbjct: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699
Query: 520 QSHETALHCA--VASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
Q T L + + H ++ LL++GANVN K K+ TPLH AA++ H ++ VL
Sbjct: 700 QDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHL 604
+HGAK NA G TAL A G++
Sbjct: 760 LQHGAKPNATTANGNTALAIAKRLGYI 786
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 311 bits (797), Expect = 3e-84
Identities = 253/793 (31%), Positives = 371/793 (46%), Gaps = 61/793 (7%)
Query: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 45 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 102
Query: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 163 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 222
Query: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
Query: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 342
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
MA + + + LLQ E D + L+ H T LH A
Sbjct: 343 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 379
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 380 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 438
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTP---I 645
T LH A+ GHL + LL G+ P++ +++ T AA+ G+ V + L ++
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498
Query: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
+ D L A++ G VK L + N N G TPLH AA V V LL
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH--TPLHIAAREGHVETVLALL 556
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
A K G PLH A YG VAELL+ A N A TPLH A +
Sbjct: 557 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 616
Query: 765 ICKLLLKHGADPTKKNRDGNTPL-------------DLVKEGDTDIQDLLRGDAALLDAA 811
I KLLL G P +G TPL L++ G + + ++G L AA
Sbjct: 617 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 676
Query: 812 KKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
++G V L + + N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 677 QEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 734
Query: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
PLH A+ YG++ + L+++ VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 735 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 794
Query: 931 MKNQEGQTPLDLA 943
+ +G TPL +A
Sbjct: 795 EVSSDGTTPLAIA 807
Score = 250 bits (638), Expect = 7e-66
Identities = 227/758 (29%), Positives = 331/758 (43%), Gaps = 131/758 (17%)
Query: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 127 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 184
Query: 257 CSFGHAEVVSLLLCQGA-----------------------------DPNARDNWNYTPLH 287
GH VV+ L+ G +P+ +TPLH
Sbjct: 185 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 244
Query: 288 EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG---------EYK-KD 337
AA ++V +LL GA N +G + L +A ++ E K KD
Sbjct: 245 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 304
Query: 338 ELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
EL AAR+G+ ++ +L A +P+H+AA + + V+LLLQ+ A+
Sbjct: 305 ELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
Query: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
+ L PLH A GH+ V ++LL GA N+ L FTPLH A KN V V LL
Sbjct: 364 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 423
Query: 455 LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTL 509
L GA V G + + +A F GH +LLQ +++ VK
Sbjct: 424 LKTGASIDAVTESGLTPLHVA-----------SFMGHLPIVKNLLQRGASPNVSNVKV-- 470
Query: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERA 569
ET LH A + H +V + LL+ A VN K KD TPLH AA
Sbjct: 471 -------------ETPLHMAARAGHT---EVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
Query: 570 HNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--- 626
H +++++L ++ A N T G T LH AA GH++T LL + + ++ +GFT
Sbjct: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 574
Query: 627 -AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS 685
AA+ G V ++L E D A K G
Sbjct: 575 VAAKYGKVRVAELLLER--------DAHPNAAGKNG-----------------------L 603
Query: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
TPLH A +N + +V+ LL G H+ G PLH A EVA L+++G S N
Sbjct: 604 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 663
Query: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGD 804
+ TPLH AA +G E+ LLL A+ N+ G TPL LV +EG + D+L
Sbjct: 664 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Query: 805 AALLDAAKK------------GCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLE 851
++DA + G + V+ L + ++N + G + PLH AA + +
Sbjct: 724 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS--PLHQAAQQGHTD 781
Query: 852 VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
+ LL++GA N G PL A G++ + +L
Sbjct: 782 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 247 bits (631), Expect = 5e-65
Identities = 207/707 (29%), Positives = 325/707 (45%), Gaps = 57/707 (8%)
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL--E 341
T AA G +D + L++G D N N +G + L LA + E E++
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 342 AARSGN----------EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
+ GN +++++ L N +A + TPL++AA N + +V+ LL++
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Query: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
GA+ + + G PL A GH V L+ +G + LH AA +
Sbjct: 167 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTA 222
Query: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPE--------LRERLTYEFKGHS----LLQAARE 499
++LL + +P +++ G + + +A E L + F + L A+R
Sbjct: 223 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 282
Query: 500 ADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFM 559
++ V+ L + + T LHCA + H + ++E+LL GA + K K+ +
Sbjct: 283 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR---ISEILLDHGAPIQAKTKNGL 339
Query: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
+P+H+AA+ H D + +L ++ A+++ + T LH AA GH + ++LL G+ P+
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 620 ISLQGFT----AAQMGNEAVQQILSE---STPIRTSDVDYRLLEASKAGDLETVKQLC-- 670
+L GFT A + + V ++L + S T L AS G L VK L
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 459
Query: 671 -SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+S NV+ +E TPLH AA V +YLL + A V+AK K PLH A GH
Sbjct: 460 GASPNVSNVKVE----TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
Query: 730 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+ +LL+ + A+ N+A TPLH AA +G E LL+ A + G TPL +
Sbjct: 516 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 575
Query: 790 V-KEGDTDIQDLLRGDAALLDAAKKGCLARVQ-----------KLCTPENINCRDTQGRN 837
K G + +LL A +AA K L + KL P +
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 635
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+ N
Sbjct: 636 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 695
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
+K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 742
Score = 243 bits (620), Expect = 9e-64
Identities = 203/647 (31%), Positives = 298/647 (46%), Gaps = 72/647 (11%)
Query: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
A RN D +R ++ + N ++ +PLH AA + +V + LL GA+V+
Sbjct: 213 AARNDD-TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271
Query: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
G+ PLH A G+ +V LLL +GA + TPLH AA G + + +LL HGA
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
Query: 309 NIRNTDGKSALDLADPS-----AKAVLTGEYKKDELL--------EAARSGNEEKLMALL 355
+ +G S + +A + +L + + D++ AA G+ LL
Sbjct: 332 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Query: 356 TP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414
N A +G TPLH+A N VR+++LLL+ GA + A + GL PLH A GH
Sbjct: 392 DKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA--------DPTLVNC 466
+ + LL+ GA N ++ TPLH AA EV LL + A D T ++C
Sbjct: 450 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509
Query: 467 HG--------KSAVDMAPTPELRERLTYEFKGHSLLQ-AAREADLAKVKKTLALEIINFK 517
K ++ P L GH+ L AARE + V L E
Sbjct: 510 AARIGHTNMVKLLLENNANPNLATTA-----GHTPLHIAAREGHVETVLALLEKEASQAC 564
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
+ T LH VA+ + K + V ELLL + A+ N K+ +TPLHVA + D++++L
Sbjct: 565 MTKKGFTPLH--VAAKYGKVR-VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 621
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
G ++ G T LH AA ++ R LL YG + S+QG T +
Sbjct: 622 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL------- 674
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNR 696
A++ G E V L S Q N N + G TPLH A
Sbjct: 675 -------------------AAQEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGH 713
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
V V + L+ HG V A + G PLH A YG+ ++ + L++H A VN ++PLH+
Sbjct: 714 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 773
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
AA +G +I LLLK+GA P + + DG TPL + K G + D+L+
Sbjct: 774 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 189 bits (481), Expect = 1e-47
Identities = 159/515 (30%), Positives = 234/515 (45%), Gaps = 57/515 (11%)
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF-----KQPQS 521
H K V++ + E T KG++ L A A +V + E++N+ Q Q
Sbjct: 90 HVKMVVELLHKEIILETTTK--KGNTALHIAALAGQDEVVR----ELVNYGANVNAQSQK 143
Query: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581
T L+ A H +V + LL GAN N +D TPL VA ++ H +V+ L +G
Sbjct: 144 GFTPLYMAAQENH---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQ 637
K + ALH AA +T +LL +P ++S GFT AA N V Q
Sbjct: 201 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 256
Query: 638 ILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690
+L R + V++ L AS+ G++ V+ L + TPLH
Sbjct: 257 LLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHC 311
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA V + E LL HGA + AK K GL P+H A H + LL+++ A ++ L
Sbjct: 312 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 371
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLD 809
TPLH AA G + + K+LL GA P + +G TPL + K+ + +LL A +D
Sbjct: 372 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 431
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A + L TPLH+A+ +L + + LL+ GA N +
Sbjct: 432 AVTESGL----------------------TPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469
Query: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
PLH AA GH ++A L++ VNA K TPLH AA+ G T + LLL + A+P
Sbjct: 470 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 529
Query: 930 TMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
+ G TPL +A + ++ + EA C
Sbjct: 530 NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 564
Score = 163 bits (413), Expect = 9e-40
Identities = 138/449 (30%), Positives = 211/449 (46%), Gaps = 34/449 (7%)
Query: 199 KRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC 257
K L+D A N++ + G +PLH A V+E LL+ GA++ A + GL PLH A
Sbjct: 388 KVLLDKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 445
Query: 258 SFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
GH +V LL +GA PN + TPLH AA G +V LLQ+ A N + D ++
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 505
Query: 318 ALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363
L A + +A L L AAR G+ E ++ALL + C
Sbjct: 506 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 565
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
G TPLH+AA Y +VR+ +LLL+ A +A K GL PLH A + + ++ +LLL
Sbjct: 566 TKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
Query: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
G ++ +TPLH AA +N+VEV LL +G + G + + +A E
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Query: 484 ----LTYEFKGH--------SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531
L+ + G+ L A+E + + ++ + T LH A
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS- 742
Query: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + + G
Sbjct: 743 --HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 800
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPSII 620
T L A G++ +L + S +
Sbjct: 801 TTPLAIAKRLGYISVTDVLKVVTDETSFV 829
Score = 144 bits (362), Expect = 7e-34
Identities = 131/495 (26%), Positives = 204/495 (41%), Gaps = 80/495 (16%)
Query: 529 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALD 588
A A K K+ + R + +K D T AA + D ++G +N +
Sbjct: 16 AQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCN 75
Query: 589 TLGQTALHRAALAGHL---------------------------------QTCRLLLSYGS 615
G LH A+ GH+ + R L++YG+
Sbjct: 76 QNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGA 135
Query: 616 DPSIISLQGFT----AAQ----------MGNEAVQQILSES--TPIRTS------DVDYR 653
+ + S +GFT AAQ + N A Q + +E TP+ + +V
Sbjct: 136 NVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAH 195
Query: 654 LLEASKAGDLETVKQLCSSQNVNCRD-------------LEGRHSTPLHFAAGYNRVSVV 700
L+ G + +++N + R L TPLH AA Y ++V
Sbjct: 196 LINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 255
Query: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
+ LL+ GA V+ + G+ PLH A G+ + LL+ GA + + TPLH AA
Sbjct: 256 QLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
Query: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG------------DTDIQDLLRGDAALL 808
G I ++LL HGA K ++G +P+ + +G D +I D+ L
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 375
Query: 809 DAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDK 868
A RV K+ + TPLH+A N++ V E LL+ GA ++A +
Sbjct: 376 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE 435
Query: 869 GGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGAD 928
GL PLH A+ GH+ I L++ N ++ TPLH AA+ G T++ LL + A
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAK 495
Query: 929 PTMKNQEGQTPLDLA 943
K ++ QTPL A
Sbjct: 496 VNAKAKDDQTPLHCA 510
Score = 135 bits (341), Expect = 2e-31
Identities = 99/311 (31%), Positives = 150/311 (48%), Gaps = 11/311 (3%)
Query: 646 RTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
+ +D L A+++G+L+ + L + ++N + G + LH A+ V +V LL
Sbjct: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELL 98
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
H + K G LH A G EV LV +GA+VN FTPL+ AA + E
Sbjct: 99 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 158
Query: 765 ICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAKKGCL 816
+ K LL++GA+ DG TPL + +++G ++ L +G L L A +
Sbjct: 159 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 218
Query: 817 ARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876
R + + N TPLH+AA Y NL VA+ LL GA VN + G+ PLH
Sbjct: 219 TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
Query: 877 AASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEG 936
A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K + G
Sbjct: 279 ASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNG 338
Query: 937 QTPLDLATADD 947
+P+ +A D
Sbjct: 339 LSPIHMAAQGD 349
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 311 bits (797), Expect = 3e-84
Identities = 253/793 (31%), Positives = 371/793 (46%), Gaps = 61/793 (7%)
Query: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
MA + + + LLQ E D + L+ H T LH A
Sbjct: 310 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTP---I 645
T LH A+ GHL + LL G+ P++ +++ T AA+ G+ V + L ++
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
+ D L A++ G VK L + N N G TPLH AA V V LL
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH--TPLHIAAREGHVETVLALL 523
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
A K G PLH A YG VAELL+ A N A TPLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
Query: 765 ICKLLLKHGADPTKKNRDGNTPL-------------DLVKEGDTDIQDLLRGDAALLDAA 811
I KLLL G P +G TPL L++ G + + ++G L AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 812 KKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
++G V L + + N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
PLH A+ YG++ + L+++ VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 931 MKNQEGQTPLDLA 943
+ +G TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 250 bits (638), Expect = 7e-66
Identities = 227/758 (29%), Positives = 331/758 (43%), Gaps = 131/758 (17%)
Query: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 94 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 257 CSFGHAEVVSLLLCQGA-----------------------------DPNARDNWNYTPLH 287
GH VV+ L+ G +P+ +TPLH
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211
Query: 288 EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG---------EYK-KD 337
AA ++V +LL GA N +G + L +A ++ E K KD
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271
Query: 338 ELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
EL AAR+G+ ++ +L A +P+H+AA + + V+LLLQ+ A+
Sbjct: 272 ELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
+ L PLH A GH+ V ++LL GA N+ L FTPLH A KN V V LL
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 455 LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTL 509
L GA V G + + +A F GH +LLQ +++ VK
Sbjct: 391 LKTGASIDAVTESGLTPLHVA-----------SFMGHLPIVKNLLQRGASPNVSNVKV-- 437
Query: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERA 569
ET LH A + H +V + LL+ A VN K KD TPLH AA
Sbjct: 438 -------------ETPLHMAARAGHT---EVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 570 HNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--- 626
H +++++L ++ A N T G T LH AA GH++T LL + + ++ +GFT
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 627 -AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS 685
AA+ G V ++L E D A K G
Sbjct: 542 VAAKYGKVRVAELLLER--------DAHPNAAGKNG-----------------------L 570
Query: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
TPLH A +N + +V+ LL G H+ G PLH A EVA L+++G S N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGD 804
+ TPLH AA +G E+ LLL A+ N+ G TPL LV +EG + D+L
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 805 AALLDAAKK------------GCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLE 851
++DA + G + V+ L + ++N + G + PLH AA + +
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS--PLHQAAQQGHTD 748
Query: 852 VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
+ LL++GA N G PL A G++ + +L
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 247 bits (631), Expect = 5e-65
Identities = 207/707 (29%), Positives = 325/707 (45%), Gaps = 57/707 (8%)
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL--E 341
T AA G +D + L++G D N N +G + L LA + E E++
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 AARSGN----------EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
+ GN +++++ L N +A + TPL++AA N + +V+ LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
GA+ + + G PL A GH V L+ +G + LH AA +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTA 189
Query: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPE--------LRERLTYEFKGHS----LLQAARE 499
++LL + +P +++ G + + +A E L + F + L A+R
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 500 ADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFM 559
++ V+ L + + T LHCA + H + ++E+LL GA + K K+ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR---ISEILLDHGAPIQAKTKNGL 306
Query: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
+P+H+AA+ H D + +L ++ A+++ + T LH AA GH + ++LL G+ P+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 620 ISLQGFT----AAQMGNEAVQQILSE---STPIRTSDVDYRLLEASKAGDLETVKQLC-- 670
+L GFT A + + V ++L + S T L AS G L VK L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 671 -SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+S NV+ +E TPLH AA V +YLL + A V+AK K PLH A GH
Sbjct: 427 GASPNVSNVKVE----TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 730 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+ +LL+ + A+ N+A TPLH AA +G E LL+ A + G TPL +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 790 V-KEGDTDIQDLLRGDAALLDAAKKGCLARVQ-----------KLCTPENINCRDTQGRN 837
K G + +LL A +AA K L + KL P +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
+K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 243 bits (620), Expect = 9e-64
Identities = 203/647 (31%), Positives = 298/647 (46%), Gaps = 72/647 (11%)
Query: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
A RN D +R ++ + N ++ +PLH AA + +V + LL GA+V+
Sbjct: 180 AARNDD-TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
G+ PLH A G+ +V LLL +GA + TPLH AA G + + +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 309 NIRNTDGKSALDLADPS-----AKAVLTGEYKKDELL--------EAARSGNEEKLMALL 355
+ +G S + +A + +L + + D++ AA G+ LL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 356 TP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414
N A +G TPLH+A N VR+++LLL+ GA + A + GL PLH A GH
Sbjct: 359 DKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA--------DPTLVNC 466
+ + LL+ GA N ++ TPLH AA EV LL + A D T ++C
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 467 HG--------KSAVDMAPTPELRERLTYEFKGHSLLQ-AAREADLAKVKKTLALEIINFK 517
K ++ P L GH+ L AARE + V L E
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTA-----GHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
+ T LH VA+ + K + V ELLL + A+ N K+ +TPLHVA + D++++L
Sbjct: 532 MTKKGFTPLH--VAAKYGKVR-VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
G ++ G T LH AA ++ R LL YG + S+QG T +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL------- 641
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNR 696
A++ G E V L S Q N N + G TPLH A
Sbjct: 642 -------------------AAQEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGH 680
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
V V + L+ HG V A + G PLH A YG+ ++ + L++H A VN ++PLH+
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
AA +G +I LLLK+GA P + + DG TPL + K G + D+L+
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 189 bits (481), Expect = 1e-47
Identities = 159/515 (30%), Positives = 234/515 (45%), Gaps = 57/515 (11%)
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF-----KQPQS 521
H K V++ + E T KG++ L A A +V + E++N+ Q Q
Sbjct: 57 HVKMVVELLHKEIILETTTK--KGNTALHIAALAGQDEVVR----ELVNYGANVNAQSQK 110
Query: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581
T L+ A H +V + LL GAN N +D TPL VA ++ H +V+ L +G
Sbjct: 111 GFTPLYMAAQENH---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQ 637
K + ALH AA +T +LL +P ++S GFT AA N V Q
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 638 ILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690
+L R + V++ L AS+ G++ V+ L + TPLH
Sbjct: 224 LLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHC 278
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA V + E LL HGA + AK K GL P+H A H + LL+++ A ++ L
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLD 809
TPLH AA G + + K+LL GA P + +G TPL + K+ + +LL A +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A + L TPLH+A+ +L + + LL+ GA N +
Sbjct: 399 AVTESGL----------------------TPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
PLH AA GH ++A L++ VNA K TPLH AA+ G T + LLL + A+P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 930 TMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
+ G TPL +A + ++ + EA C
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Score = 163 bits (413), Expect = 9e-40
Identities = 138/449 (30%), Positives = 211/449 (46%), Gaps = 34/449 (7%)
Query: 199 KRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC 257
K L+D A N++ + G +PLH A V+E LL+ GA++ A + GL PLH A
Sbjct: 355 KVLLDKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 258 SFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
GH +V LL +GA PN + TPLH AA G +V LLQ+ A N + D ++
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 318 ALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363
L A + +A L L AAR G+ E ++ALL + C
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
G TPLH+AA Y +VR+ +LLL+ A +A K GL PLH A + + ++ +LLL
Sbjct: 533 TKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
G ++ +TPLH AA +N+VEV LL +G + G + + +A E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 484 ----LTYEFKGH--------SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531
L+ + G+ L A+E + + ++ + T LH A
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS- 709
Query: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + + G
Sbjct: 710 --HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPSII 620
T L A G++ +L + S +
Sbjct: 768 TTPLAIAKRLGYISVTDVLKVVTDETSFV 796
Score = 137 bits (346), Expect = 5e-32
Identities = 101/315 (32%), Positives = 151/315 (47%), Gaps = 11/315 (3%)
Query: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700
S R +D L A+++G+L+ + L + ++N + G + LH A+ V +V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMV 61
Query: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
LLH + K G LH A G EV LV +GA+VN FTPL+ AA +
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAK 812
E+ K LL++GA+ DG TPL + +++G ++ L +G L L A
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
+ R + + N TPLH+AA Y NL VA+ LL GA VN + G+
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932
PLH A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 933 NQEGQTPLDLATADD 947
+ G +P+ +A D
Sbjct: 302 TKNGLSPIHMAAQGD 316
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 311 bits (797), Expect = 3e-84
Identities = 253/793 (31%), Positives = 371/793 (46%), Gaps = 61/793 (7%)
Query: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
MA + + + LLQ E D + L+ H T LH A
Sbjct: 310 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTP---I 645
T LH A+ GHL + LL G+ P++ +++ T AA+ G+ V + L ++
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
+ D L A++ G VK L + N N G TPLH AA V V LL
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH--TPLHIAAREGHVETVLALL 523
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
A K G PLH A YG VAELL+ A N A TPLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
Query: 765 ICKLLLKHGADPTKKNRDGNTPL-------------DLVKEGDTDIQDLLRGDAALLDAA 811
I KLLL G P +G TPL L++ G + + ++G L AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 812 KKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
++G V L + + N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
PLH A+ YG++ + L+++ VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 931 MKNQEGQTPLDLA 943
+ +G TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 250 bits (638), Expect = 7e-66
Identities = 227/758 (29%), Positives = 331/758 (43%), Gaps = 131/758 (17%)
Query: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 94 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 257 CSFGHAEVVSLLLCQGA-----------------------------DPNARDNWNYTPLH 287
GH VV+ L+ G +P+ +TPLH
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211
Query: 288 EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG---------EYK-KD 337
AA ++V +LL GA N +G + L +A ++ E K KD
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271
Query: 338 ELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
EL AAR+G+ ++ +L A +P+H+AA + + V+LLLQ+ A+
Sbjct: 272 ELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
+ L PLH A GH+ V ++LL GA N+ L FTPLH A KN V V LL
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 455 LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTL 509
L GA V G + + +A F GH +LLQ +++ VK
Sbjct: 391 LKTGASIDAVTESGLTPLHVA-----------SFMGHLPIVKNLLQRGASPNVSNVKV-- 437
Query: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERA 569
ET LH A + H +V + LL+ A VN K KD TPLH AA
Sbjct: 438 -------------ETPLHMAARAGHT---EVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 570 HNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--- 626
H +++++L ++ A N T G T LH AA GH++T LL + + ++ +GFT
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 627 -AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS 685
AA+ G V ++L E D A K G
Sbjct: 542 VAAKYGKVRVAELLLER--------DAHPNAAGKNG-----------------------L 570
Query: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
TPLH A +N + +V+ LL G H+ G PLH A EVA L+++G S N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGD 804
+ TPLH AA +G E+ LLL A+ N+ G TPL LV +EG + D+L
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 805 AALLDAAKK------------GCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLE 851
++DA + G + V+ L + ++N + G + PLH AA + +
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS--PLHQAAQQGHTD 748
Query: 852 VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
+ LL++GA N G PL A G++ + +L
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 247 bits (631), Expect = 5e-65
Identities = 207/707 (29%), Positives = 325/707 (45%), Gaps = 57/707 (8%)
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL--E 341
T AA G +D + L++G D N N +G + L LA + E E++
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 AARSGN----------EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
+ GN +++++ L N +A + TPL++AA N + +V+ LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
GA+ + + G PL A GH V L+ +G + LH AA +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTA 189
Query: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPE--------LRERLTYEFKGHS----LLQAARE 499
++LL + +P +++ G + + +A E L + F + L A+R
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 500 ADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFM 559
++ V+ L + + T LHCA + H + ++E+LL GA + K K+ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR---ISEILLDHGAPIQAKTKNGL 306
Query: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
+P+H+AA+ H D + +L ++ A+++ + T LH AA GH + ++LL G+ P+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 620 ISLQGFT----AAQMGNEAVQQILSE---STPIRTSDVDYRLLEASKAGDLETVKQLC-- 670
+L GFT A + + V ++L + S T L AS G L VK L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 671 -SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+S NV+ +E TPLH AA V +YLL + A V+AK K PLH A GH
Sbjct: 427 GASPNVSNVKVE----TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 730 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+ +LL+ + A+ N+A TPLH AA +G E LL+ A + G TPL +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 790 V-KEGDTDIQDLLRGDAALLDAAKKGCLARVQ-----------KLCTPENINCRDTQGRN 837
K G + +LL A +AA K L + KL P +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
+K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 243 bits (620), Expect = 9e-64
Identities = 203/647 (31%), Positives = 298/647 (46%), Gaps = 72/647 (11%)
Query: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
A RN D +R ++ + N ++ +PLH AA + +V + LL GA+V+
Sbjct: 180 AARNDD-TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
G+ PLH A G+ +V LLL +GA + TPLH AA G + + +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 309 NIRNTDGKSALDLADPS-----AKAVLTGEYKKDELL--------EAARSGNEEKLMALL 355
+ +G S + +A + +L + + D++ AA G+ LL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 356 TP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414
N A +G TPLH+A N VR+++LLL+ GA + A + GL PLH A GH
Sbjct: 359 DKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA--------DPTLVNC 466
+ + LL+ GA N ++ TPLH AA EV LL + A D T ++C
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 467 HG--------KSAVDMAPTPELRERLTYEFKGHSLLQ-AAREADLAKVKKTLALEIINFK 517
K ++ P L GH+ L AARE + V L E
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTA-----GHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
+ T LH VA+ + K + V ELLL + A+ N K+ +TPLHVA + D++++L
Sbjct: 532 MTKKGFTPLH--VAAKYGKVR-VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
G ++ G T LH AA ++ R LL YG + S+QG T +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL------- 641
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNR 696
A++ G E V L S Q N N + G TPLH A
Sbjct: 642 -------------------AAQEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGH 680
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
V V + L+ HG V A + G PLH A YG+ ++ + L++H A VN ++PLH+
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
AA +G +I LLLK+GA P + + DG TPL + K G + D+L+
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 189 bits (481), Expect = 1e-47
Identities = 159/515 (30%), Positives = 234/515 (45%), Gaps = 57/515 (11%)
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF-----KQPQS 521
H K V++ + E T KG++ L A A +V + E++N+ Q Q
Sbjct: 57 HVKMVVELLHKEIILETTTK--KGNTALHIAALAGQDEVVR----ELVNYGANVNAQSQK 110
Query: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581
T L+ A H +V + LL GAN N +D TPL VA ++ H +V+ L +G
Sbjct: 111 GFTPLYMAAQENH---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQ 637
K + ALH AA +T +LL +P ++S GFT AA N V Q
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 638 ILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690
+L R + V++ L AS+ G++ V+ L + TPLH
Sbjct: 224 LLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHC 278
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA V + E LL HGA + AK K GL P+H A H + LL+++ A ++ L
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLD 809
TPLH AA G + + K+LL GA P + +G TPL + K+ + +LL A +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A + L TPLH+A+ +L + + LL+ GA N +
Sbjct: 399 AVTESGL----------------------TPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
PLH AA GH ++A L++ VNA K TPLH AA+ G T + LLL + A+P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 930 TMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
+ G TPL +A + ++ + EA C
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Score = 163 bits (413), Expect = 9e-40
Identities = 138/449 (30%), Positives = 211/449 (46%), Gaps = 34/449 (7%)
Query: 199 KRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC 257
K L+D A N++ + G +PLH A V+E LL+ GA++ A + GL PLH A
Sbjct: 355 KVLLDKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 258 SFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
GH +V LL +GA PN + TPLH AA G +V LLQ+ A N + D ++
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 318 ALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363
L A + +A L L AAR G+ E ++ALL + C
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
G TPLH+AA Y +VR+ +LLL+ A +A K GL PLH A + + ++ +LLL
Sbjct: 533 TKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
G ++ +TPLH AA +N+VEV LL +G + G + + +A E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 484 ----LTYEFKGH--------SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531
L+ + G+ L A+E + + ++ + T LH A
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS- 709
Query: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + + G
Sbjct: 710 --HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPSII 620
T L A G++ +L + S +
Sbjct: 768 TTPLAIAKRLGYISVTDVLKVVTDETSFV 796
Score = 137 bits (346), Expect = 5e-32
Identities = 101/315 (32%), Positives = 151/315 (47%), Gaps = 11/315 (3%)
Query: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700
S R +D L A+++G+L+ + L + ++N + G + LH A+ V +V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMV 61
Query: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
LLH + K G LH A G EV LV +GA+VN FTPL+ AA +
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAK 812
E+ K LL++GA+ DG TPL + +++G ++ L +G L L A
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
+ R + + N TPLH+AA Y NL VA+ LL GA VN + G+
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932
PLH A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 933 NQEGQTPLDLATADD 947
+ G +P+ +A D
Sbjct: 302 TKNGLSPIHMAAQGD 316
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 311 bits (797), Expect = 3e-84
Identities = 253/793 (31%), Positives = 371/793 (46%), Gaps = 61/793 (7%)
Query: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
MA + + + LLQ E D + L+ H T LH A
Sbjct: 310 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTP---I 645
T LH A+ GHL + LL G+ P++ +++ T AA+ G+ V + L ++
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
+ D L A++ G VK L + N N G TPLH AA V V LL
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH--TPLHIAAREGHVETVLALL 523
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
A K G PLH A YG VAELL+ A N A TPLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
Query: 765 ICKLLLKHGADPTKKNRDGNTPL-------------DLVKEGDTDIQDLLRGDAALLDAA 811
I KLLL G P +G TPL L++ G + + ++G L AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 812 KKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
++G V L + + N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
PLH A+ YG++ + L+++ VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 931 MKNQEGQTPLDLA 943
+ +G TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 250 bits (638), Expect = 7e-66
Identities = 227/758 (29%), Positives = 331/758 (43%), Gaps = 131/758 (17%)
Query: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 94 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 257 CSFGHAEVVSLLLCQGA-----------------------------DPNARDNWNYTPLH 287
GH VV+ L+ G +P+ +TPLH
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211
Query: 288 EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG---------EYK-KD 337
AA ++V +LL GA N +G + L +A ++ E K KD
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271
Query: 338 ELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
EL AAR+G+ ++ +L A +P+H+AA + + V+LLLQ+ A+
Sbjct: 272 ELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
+ L PLH A GH+ V ++LL GA N+ L FTPLH A KN V V LL
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 455 LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTL 509
L GA V G + + +A F GH +LLQ +++ VK
Sbjct: 391 LKTGASIDAVTESGLTPLHVA-----------SFMGHLPIVKNLLQRGASPNVSNVKV-- 437
Query: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERA 569
ET LH A + H +V + LL+ A VN K KD TPLH AA
Sbjct: 438 -------------ETPLHMAARAGHT---EVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 570 HNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--- 626
H +++++L ++ A N T G T LH AA GH++T LL + + ++ +GFT
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 627 -AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS 685
AA+ G V ++L E D A K G
Sbjct: 542 VAAKYGKVRVAELLLER--------DAHPNAAGKNG-----------------------L 570
Query: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
TPLH A +N + +V+ LL G H+ G PLH A EVA L+++G S N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGD 804
+ TPLH AA +G E+ LLL A+ N+ G TPL LV +EG + D+L
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 805 AALLDAAKK------------GCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLE 851
++DA + G + V+ L + ++N + G + PLH AA + +
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS--PLHQAAQQGHTD 748
Query: 852 VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
+ LL++GA N G PL A G++ + +L
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 247 bits (631), Expect = 5e-65
Identities = 207/707 (29%), Positives = 325/707 (45%), Gaps = 57/707 (8%)
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL--E 341
T AA G +D + L++G D N N +G + L LA + E E++
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 AARSGN----------EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
+ GN +++++ L N +A + TPL++AA N + +V+ LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
GA+ + + G PL A GH V L+ +G + LH AA +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTA 189
Query: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPE--------LRERLTYEFKGHS----LLQAARE 499
++LL + +P +++ G + + +A E L + F + L A+R
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 500 ADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFM 559
++ V+ L + + T LHCA + H + ++E+LL GA + K K+ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR---ISEILLDHGAPIQAKTKNGL 306
Query: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
+P+H+AA+ H D + +L ++ A+++ + T LH AA GH + ++LL G+ P+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 620 ISLQGFT----AAQMGNEAVQQILSE---STPIRTSDVDYRLLEASKAGDLETVKQLC-- 670
+L GFT A + + V ++L + S T L AS G L VK L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 671 -SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+S NV+ +E TPLH AA V +YLL + A V+AK K PLH A GH
Sbjct: 427 GASPNVSNVKVE----TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 730 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+ +LL+ + A+ N+A TPLH AA +G E LL+ A + G TPL +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 790 V-KEGDTDIQDLLRGDAALLDAAKKGCLARVQ-----------KLCTPENINCRDTQGRN 837
K G + +LL A +AA K L + KL P +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
+K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 243 bits (620), Expect = 9e-64
Identities = 203/647 (31%), Positives = 298/647 (46%), Gaps = 72/647 (11%)
Query: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
A RN D +R ++ + N ++ +PLH AA + +V + LL GA+V+
Sbjct: 180 AARNDD-TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
G+ PLH A G+ +V LLL +GA + TPLH AA G + + +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 309 NIRNTDGKSALDLADPS-----AKAVLTGEYKKDELL--------EAARSGNEEKLMALL 355
+ +G S + +A + +L + + D++ AA G+ LL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 356 TP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414
N A +G TPLH+A N VR+++LLL+ GA + A + GL PLH A GH
Sbjct: 359 DKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA--------DPTLVNC 466
+ + LL+ GA N ++ TPLH AA EV LL + A D T ++C
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 467 HG--------KSAVDMAPTPELRERLTYEFKGHSLLQ-AAREADLAKVKKTLALEIINFK 517
K ++ P L GH+ L AARE + V L E
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTA-----GHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
+ T LH VA+ + K + V ELLL + A+ N K+ +TPLHVA + D++++L
Sbjct: 532 MTKKGFTPLH--VAAKYGKVR-VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
G ++ G T LH AA ++ R LL YG + S+QG T +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL------- 641
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNR 696
A++ G E V L S Q N N + G TPLH A
Sbjct: 642 -------------------AAQEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGH 680
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
V V + L+ HG V A + G PLH A YG+ ++ + L++H A VN ++PLH+
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
AA +G +I LLLK+GA P + + DG TPL + K G + D+L+
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 189 bits (481), Expect = 1e-47
Identities = 159/515 (30%), Positives = 234/515 (45%), Gaps = 57/515 (11%)
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF-----KQPQS 521
H K V++ + E T KG++ L A A +V + E++N+ Q Q
Sbjct: 57 HVKMVVELLHKEIILETTTK--KGNTALHIAALAGQDEVVR----ELVNYGANVNAQSQK 110
Query: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581
T L+ A H +V + LL GAN N +D TPL VA ++ H +V+ L +G
Sbjct: 111 GFTPLYMAAQENH---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQ 637
K + ALH AA +T +LL +P ++S GFT AA N V Q
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 638 ILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690
+L R + V++ L AS+ G++ V+ L + TPLH
Sbjct: 224 LLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHC 278
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA V + E LL HGA + AK K GL P+H A H + LL+++ A ++ L
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLD 809
TPLH AA G + + K+LL GA P + +G TPL + K+ + +LL A +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A + L TPLH+A+ +L + + LL+ GA N +
Sbjct: 399 AVTESGL----------------------TPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
PLH AA GH ++A L++ VNA K TPLH AA+ G T + LLL + A+P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 930 TMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
+ G TPL +A + ++ + EA C
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Score = 163 bits (413), Expect = 9e-40
Identities = 138/449 (30%), Positives = 211/449 (46%), Gaps = 34/449 (7%)
Query: 199 KRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC 257
K L+D A N++ + G +PLH A V+E LL+ GA++ A + GL PLH A
Sbjct: 355 KVLLDKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 258 SFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
GH +V LL +GA PN + TPLH AA G +V LLQ+ A N + D ++
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 318 ALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363
L A + +A L L AAR G+ E ++ALL + C
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
G TPLH+AA Y +VR+ +LLL+ A +A K GL PLH A + + ++ +LLL
Sbjct: 533 TKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
G ++ +TPLH AA +N+VEV LL +G + G + + +A E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 484 ----LTYEFKGH--------SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531
L+ + G+ L A+E + + ++ + T LH A
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS- 709
Query: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + + G
Sbjct: 710 --HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPSII 620
T L A G++ +L + S +
Sbjct: 768 TTPLAIAKRLGYISVTDVLKVVTDETSFV 796
Score = 137 bits (346), Expect = 5e-32
Identities = 101/315 (32%), Positives = 151/315 (47%), Gaps = 11/315 (3%)
Query: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700
S R +D L A+++G+L+ + L + ++N + G + LH A+ V +V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMV 61
Query: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
LLH + K G LH A G EV LV +GA+VN FTPL+ AA +
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAK 812
E+ K LL++GA+ DG TPL + +++G ++ L +G L L A
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
+ R + + N TPLH+AA Y NL VA+ LL GA VN + G+
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932
PLH A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 933 NQEGQTPLDLATADD 947
+ G +P+ +A D
Sbjct: 302 TKNGLSPIHMAAQGD 316
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 311 bits (797), Expect = 3e-84
Identities = 253/793 (31%), Positives = 371/793 (46%), Gaps = 61/793 (7%)
Query: 182 ALRELLEACRNGDVSR-VKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGA 240
A L A R+G++ + + L + ++N + G LH A+ G +V LL
Sbjct: 12 AATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEI 69
Query: 241 NVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIV 300
+ G LH A G EVV L+ GA+ NA+ +TPL+ AA + ++V
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 129
Query: 301 LLQHGADPNIRNTDGKSALDLA------DPSAKAVLTGEYKKDEL--LEAARSGNEEKLM 352
LL++GA+ N+ DG + L +A + A + G K L L A ++ +
Sbjct: 130 LLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTA 189
Query: 353 ALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSY 412
A+L + N TPLH+AA Y + + QLLL GA V+ + G+ PLH A
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 413 GHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
G+ + LLL GA + + TPLH AA V + +LL HGA +G S +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI 309
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
MA + + + LLQ E D + L+ H T LH A
Sbjct: 310 HMAAQGDHLDCVRL------LLQYDAEID------DITLD---------HLTPLHVAA-- 346
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H +V ++LL KGA N + + TPLH+A ++ H VME+L K GA ++A+ G
Sbjct: 347 -HCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGL 405
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTP---I 645
T LH A+ GHL + LL G+ P++ +++ T AA+ G+ V + L ++
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465
Query: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
+ D L A++ G VK L + N N G TPLH AA V V LL
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH--TPLHIAAREGHVETVLALL 523
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE 764
A K G PLH A YG VAELL+ A N A TPLH A +
Sbjct: 524 EKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD 583
Query: 765 ICKLLLKHGADPTKKNRDGNTPL-------------DLVKEGDTDIQDLLRGDAALLDAA 811
I KLLL G P +G TPL L++ G + + ++G L AA
Sbjct: 584 IVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAA 643
Query: 812 KKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
++G V L + + N N + G TPLHL A ++ VA+ L++HG V+A + G
Sbjct: 644 QEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGHVPVADVLIKHGVMVDATTRMG 701
Query: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
PLH A+ YG++ + L+++ VNA K ++PLH+AAQ+G T + LLL +GA P
Sbjct: 702 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPN 761
Query: 931 MKNQEGQTPLDLA 943
+ +G TPL +A
Sbjct: 762 EVSSDGTTPLAIA 774
Score = 250 bits (638), Expect = 7e-66
Identities = 227/758 (29%), Positives = 331/758 (43%), Gaps = 131/758 (17%)
Query: 198 VKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNA 256
V+ LV+ ANVNA+ G +PL+ AA +VV+ LL+ GAN + + G PL A
Sbjct: 94 VRELVNYGANVNAQSQKG--FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Query: 257 CSFGHAEVVSLLLCQGA-----------------------------DPNARDNWNYTPLH 287
GH VV+ L+ G +P+ +TPLH
Sbjct: 152 LQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLH 211
Query: 288 EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTG---------EYK-KD 337
AA ++V +LL GA N +G + L +A ++ E K KD
Sbjct: 212 IAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKD 271
Query: 338 ELLE---AARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
EL AAR+G+ ++ +L A +P+H+AA + + V+LLLQ+ A+
Sbjct: 272 ELTPLHCAARNGHV-RISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLL 454
+ L PLH A GH+ V ++LL GA N+ L FTPLH A KN V V LL
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 455 LSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTL 509
L GA V G + + +A F GH +LLQ +++ VK
Sbjct: 391 LKTGASIDAVTESGLTPLHVA-----------SFMGHLPIVKNLLQRGASPNVSNVKV-- 437
Query: 510 ALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERA 569
ET LH A + H +V + LL+ A VN K KD TPLH AA
Sbjct: 438 -------------ETPLHMAARAGHT---EVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 570 HNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT--- 626
H +++++L ++ A N T G T LH AA GH++T LL + + ++ +GFT
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 627 -AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS 685
AA+ G V ++L E D A K G
Sbjct: 542 VAAKYGKVRVAELLLER--------DAHPNAAGKNG-----------------------L 570
Query: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV 745
TPLH A +N + +V+ LL G H+ G PLH A EVA L+++G S N
Sbjct: 571 TPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANA 630
Query: 746 ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGD 804
+ TPLH AA +G E+ LLL A+ N+ G TPL LV +EG + D+L
Sbjct: 631 ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Query: 805 AALLDAAKK------------GCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLE 851
++DA + G + V+ L + ++N + G + PLH AA + +
Sbjct: 691 GVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYS--PLHQAAQQGHTD 748
Query: 852 VAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
+ LL++GA N G PL A G++ + +L
Sbjct: 749 IVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 247 bits (631), Expect = 5e-65
Identities = 207/707 (29%), Positives = 325/707 (45%), Gaps = 57/707 (8%)
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL--E 341
T AA G +D + L++G D N N +G + L LA + E E++
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 342 AARSGN----------EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQH 391
+ GN +++++ L N +A + TPL++AA N + +V+ LL++
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
GA+ + + G PL A GH V L+ +G + LH AA +
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKV----RLPALHIAARNDDTRTA 189
Query: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPE--------LRERLTYEFKGHS----LLQAARE 499
++LL + +P +++ G + + +A E L + F + L A+R
Sbjct: 190 AVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRR 249
Query: 500 ADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFM 559
++ V+ L + + T LHCA + H + ++E+LL GA + K K+ +
Sbjct: 250 GNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR---ISEILLDHGAPIQAKTKNGL 306
Query: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
+P+H+AA+ H D + +L ++ A+++ + T LH AA GH + ++LL G+ P+
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 620 ISLQGFT----AAQMGNEAVQQILSE---STPIRTSDVDYRLLEASKAGDLETVKQLC-- 670
+L GFT A + + V ++L + S T L AS G L VK L
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQR 426
Query: 671 -SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+S NV+ +E TPLH AA V +YLL + A V+AK K PLH A GH
Sbjct: 427 GASPNVSNVKVE----TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 730 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+ +LL+ + A+ N+A TPLH AA +G E LL+ A + G TPL +
Sbjct: 483 TNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHV 542
Query: 790 V-KEGDTDIQDLLRGDAALLDAAKKGCLARVQ-----------KLCTPENINCRDTQGRN 837
K G + +LL A +AA K L + KL P +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNG 602
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVN 897
TPLH+AA N +EVA LL++G NA+ G+ PLH AA GH ++ ALL+ N
Sbjct: 603 YTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN 662
Query: 898 ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
+K TPLH AQ+G + +L+ HG + G TPL +A+
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS 709
Score = 243 bits (620), Expect = 9e-64
Identities = 203/647 (31%), Positives = 298/647 (46%), Gaps = 72/647 (11%)
Query: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDG 248
A RN D +R ++ + N ++ +PLH AA + +V + LL GA+V+
Sbjct: 180 AARNDD-TRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 249 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADP 308
G+ PLH A G+ +V LLL +GA + TPLH AA G + + +LL HGA
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 309 NIRNTDGKSALDLADPS-----AKAVLTGEYKKDELL--------EAARSGNEEKLMALL 355
+ +G S + +A + +L + + D++ AA G+ LL
Sbjct: 299 QAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Query: 356 TP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414
N A +G TPLH+A N VR+++LLL+ GA + A + GL PLH A GH
Sbjct: 359 DKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA--------DPTLVNC 466
+ + LL+ GA N ++ TPLH AA EV LL + A D T ++C
Sbjct: 417 LPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Query: 467 HG--------KSAVDMAPTPELRERLTYEFKGHSLLQ-AAREADLAKVKKTLALEIINFK 517
K ++ P L GH+ L AARE + V L E
Sbjct: 477 AARIGHTNMVKLLLENNANPNLATTA-----GHTPLHIAAREGHVETVLALLEKEASQAC 531
Query: 518 QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL 577
+ T LH VA+ + K + V ELLL + A+ N K+ +TPLHVA + D++++L
Sbjct: 532 MTKKGFTPLH--VAAKYGKVR-VAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLL 588
Query: 578 HKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637
G ++ G T LH AA ++ R LL YG + S+QG T +
Sbjct: 589 LPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL------- 641
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNR 696
A++ G E V L S Q N N + G TPLH A
Sbjct: 642 -------------------AAQEGHAEMVALLLSKQANGNLGNKSGL--TPLHLVAQEGH 680
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
V V + L+ HG V A + G PLH A YG+ ++ + L++H A VN ++PLH+
Sbjct: 681 VPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQ 740
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
AA +G +I LLLK+GA P + + DG TPL + K G + D+L+
Sbjct: 741 AAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 189 bits (481), Expect = 1e-47
Identities = 159/515 (30%), Positives = 234/515 (45%), Gaps = 57/515 (11%)
Query: 467 HGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINF-----KQPQS 521
H K V++ + E T KG++ L A A +V + E++N+ Q Q
Sbjct: 57 HVKMVVELLHKEIILETTTK--KGNTALHIAALAGQDEVVR----ELVNYGANVNAQSQK 110
Query: 522 HETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG 581
T L+ A H +V + LL GAN N +D TPL VA ++ H +V+ L +G
Sbjct: 111 GFTPLYMAAQENH---LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 582 AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQ 637
K + ALH AA +T +LL +P ++S GFT AA N V Q
Sbjct: 168 TK----GKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQ 223
Query: 638 ILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690
+L R + V++ L AS+ G++ V+ L + TPLH
Sbjct: 224 LLLN----RGASVNFTPQNGITPLHIASRRGNVIMVRLLLD-RGAQIETKTKDELTPLHC 278
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA V + E LL HGA + AK K GL P+H A H + LL+++ A ++ L
Sbjct: 279 AARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH 338
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLV-KEGDTDIQDLLRGDAALLD 809
TPLH AA G + + K+LL GA P + +G TPL + K+ + +LL A +D
Sbjct: 339 LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID 398
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A + L TPLH+A+ +L + + LL+ GA N +
Sbjct: 399 AVTESGL----------------------TPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436
Query: 870 GLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 929
PLH AA GH ++A L++ VNA K TPLH AA+ G T + LLL + A+P
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 930 TMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC 964
+ G TPL +A + ++ + EA C
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531
Score = 163 bits (413), Expect = 9e-40
Identities = 138/449 (30%), Positives = 211/449 (46%), Gaps = 34/449 (7%)
Query: 199 KRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNAC 257
K L+D A N++ + G +PLH A V+E LL+ GA++ A + GL PLH A
Sbjct: 355 KVLLDKGAKPNSRALNG--FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVAS 412
Query: 258 SFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKS 317
GH +V LL +GA PN + TPLH AA G +V LLQ+ A N + D ++
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQT 472
Query: 318 ALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNVNCH 363
L A + +A L L AAR G+ E ++ALL + C
Sbjct: 473 PLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACM 532
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
G TPLH+AA Y +VR+ +LLL+ A +A K GL PLH A + + ++ +LLL
Sbjct: 533 TKKG--FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 424 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER 483
G ++ +TPLH AA +N+VEV LL +G + G + + +A E
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 484 ----LTYEFKGH--------SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA 531
L+ + G+ L A+E + + ++ + T LH A
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVAS- 709
Query: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591
H ++ + LL+ A+VN K K +PLH AA++ H D++ +L K+GA N + + G
Sbjct: 710 --HYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDG 767
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPSII 620
T L A G++ +L + S +
Sbjct: 768 TTPLAIAKRLGYISVTDVLKVVTDETSFV 796
Score = 137 bits (346), Expect = 5e-32
Identities = 101/315 (32%), Positives = 151/315 (47%), Gaps = 11/315 (3%)
Query: 642 STPIRTSDVDYRLLEASKAGDLE-TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVV 700
S R +D L A+++G+L+ + L + ++N + G + LH A+ V +V
Sbjct: 4 SVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMV 61
Query: 701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAK 760
LLH + K G LH A G EV LV +GA+VN FTPL+ AA +
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 761 GKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLL-----RGDAAL--LDAAK 812
E+ K LL++GA+ DG TPL + +++G ++ L +G L L A
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 813 KGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
+ R + + N TPLH+AA Y NL VA+ LL GA VN + G+
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 873 PLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932
PLH A+ G+V + LL+ + K TPLH AA+ G ++ +LL HGA K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 933 NQEGQTPLDLATADD 947
+ G +P+ +A D
Sbjct: 302 TKNGLSPIHMAAQGD 316
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 246 bits (628), Expect = 1e-64
Identities = 268/909 (29%), Positives = 384/909 (42%), Gaps = 152/909 (16%)
Query: 186 LLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
L++A NGD V+ L+ +VN +D K +PLH AA G +++E L+ GA V+A
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQD--NEKRTPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQ 303
+D L PLH A + E V +LL AD NARD NW TPLH AA + L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQ-TPLHIAAANKAVKCAEALVP 128
Query: 304 HGADPNIRNTDGKSALDLADPSAK-----------AVLTGEYKKDE--LLEAARSGNEEK 350
++ N+ + G++AL A S A + KKD + AA G+ E
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIE- 187
Query: 351 LMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNAC 410
++ LL D + TPLH AA + +V+ LL G D++ + G PLH AC
Sbjct: 188 VVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC 247
Query: 411 SYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC-SLLLSHGADPTLVNCHGK 469
G V L+ GA VN + FTPLH AA+ +C LL+ +GAD + + GK
Sbjct: 248 YNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGK 307
Query: 470 SAVDMAP--------------------------TP-ELRERLTYEFKGHSLLQAAREADL 502
+ + M TP + R +E ++L+ + AD
Sbjct: 308 TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSG--ADT 365
Query: 503 AK--------------------VKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTE 542
AK +K L+ T LH A A +
Sbjct: 366 AKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAG---GNLECLN 422
Query: 543 LLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAG 602
LLL GA+ N+K+K +PLH AA + + L GA +N LD G T LH AA +
Sbjct: 423 LLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482
Query: 603 HLQTC-RLLLSYGSDPSIISLQGFTA----AQMGNEAVQQILSESTPI----------RT 647
C LL ++P I QG+ A A G+ Q+++ TP+
Sbjct: 483 TDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDML 542
Query: 648 SDVDYR-----LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701
SD D R L A+ G + ++ L S +++ R+ GR TPL AA V V+
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGR--TPLDLAAFKGHVECVD 600
Query: 702 YLLHHGADVHAKDK-GGLVPLHNACSYGHYEVAELLV----------------------- 737
L++ GA + KD P+H A + GH E LL+
Sbjct: 601 VLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS 660
Query: 738 -------------RHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGN 784
GA+V+ D W T LH A G E LL+HGA ++ G
Sbjct: 661 VLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR 720
Query: 785 TPLDLVKE-GDTDIQDLLRGDAALLDA----AKKGCLARVQKLCTPENINC--------- 830
TP+ L G + L AA +DA A + C + C
Sbjct: 721 TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV 780
Query: 831 -RDTQGRNSTPLHLAAGYNNLEVAEYLLEH-GAD-VNAQDKGGLIPLHNAASYGHVDIAA 887
+ T+G +PLH A +N AE L++ GA VNA D G PLH AA HV+
Sbjct: 781 FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
Query: 888 LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH-GADPTMKNQEGQTPLDLATA- 945
LL+ +N VN+ D TPL AA+ G+T +L++ A+ T+++ T L LA +
Sbjct: 841 LLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK 900
Query: 946 -DDIRALLI 953
+ ALLI
Sbjct: 901 GHETSALLI 909
Score = 221 bits (562), Expect = 5e-57
Identities = 250/863 (28%), Positives = 365/863 (42%), Gaps = 158/863 (18%)
Query: 193 GDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
G + VK LV A V KD + +PLH AA G VV++LL +G +++ + G
Sbjct: 184 GHIEVVKLLVSHGAEVTCKDK--KSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNT 241
Query: 252 PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQ-HGADPNI 310
PLH AC G VV+ L+ GA N ++ +TPLH AA +C+ LL +GAD N+
Sbjct: 242 PLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM 301
Query: 311 RNTDGKSALDLADPSAK-----------AVLTGEYKKDE--LLEAARSGNEEKLMALLT- 356
++ DGK+ L + + AV+ E K L AAR G+E + L+T
Sbjct: 302 KSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITS 361
Query: 357 -------------PLNV------------------NCHASDGRKSTPLHLAAGYNRVRIV 385
PL++ + D T LH AA + +
Sbjct: 362 GADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL 421
Query: 386 QLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASK 445
LLL GAD + KDK G PLH A + +Y+ L+ GA VN +D TPLH AA+
Sbjct: 422 NLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATS 481
Query: 446 NRVEVC-SLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL-LQA-AREADL 502
+ C LL + A+P + + G +AV + GH L LQ A E L
Sbjct: 482 DTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAA-----------YGHRLCLQLIASETPL 530
Query: 503 AKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
+ +T ++++ ++ + LH A H Q E+L++ +++ +N TPL
Sbjct: 531 DVLMETSGTDMLSDSDNRATISPLHLAAYHGH---HQALEVLVQSLLDLDVRNSSGRTPL 587
Query: 563 HVAAERAHNDVMEVLHKHGAKMNALD-TLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS 621
+AA + H + ++VL GA + D L +T +H AA GH + RLL+ + +
Sbjct: 588 DLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVD 647
Query: 622 LQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLE 681
+Q GN +LS +D Y LL NV+ +D
Sbjct: 648 IQD------GNGQTPLMLSVLNG--HTDCVYSLLN--------------KGANVDAKDKW 685
Query: 682 GRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA 741
GR T LH A V+ LL HGA +D G P+H + + GH V L++ A
Sbjct: 686 GR--TALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAA 743
Query: 742 SVNV----ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDI 797
S++ AD +T LH A G +E C LL K + +PL D +
Sbjct: 744 SMDANPATADNHGYTALHWACYNG-HETCVELLLEQEVFQKTEGNAFSPLHCAVINDNE- 801
Query: 798 QDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLL 857
G A +L + +N D++GR TPLH AA +++E + LL
Sbjct: 802 -----GAAEMLIDTLGASI-----------VNATDSKGR--TPLHAAAFTDHVECLQLLL 843
Query: 858 EHGADVNAQDKGGLIPL----------------------------------HNAASYGHV 883
H A VN+ D G PL H A S GH
Sbjct: 844 SHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHE 903
Query: 884 DIAALLIKYNT---CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
A L+++ T +NAT+ TPLH AA+ G T + LL GA ++ G TP
Sbjct: 904 TSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPA 963
Query: 941 DLATAD-----DIRALLIDAMPP 958
LA A D AL++ M P
Sbjct: 964 -LACAPNKDVADCLALILATMMP 985
Score = 129 bits (323), Expect = 2e-29
Identities = 100/305 (32%), Positives = 147/305 (48%), Gaps = 26/305 (8%)
Query: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
L++A GD + V+ L ++VN +D E R TPLH AA ++E L+ GA V+A
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKR--TPLHAAAYLGDAEIIELLILSGARVNA 69
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
KD L PLH A + E ++L++H A VN D TPLH AAA + + L+
Sbjct: 70 KDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPL 129
Query: 773 GADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCR 831
++ +R G T AL AA G V+ L + NIN
Sbjct: 130 LSNVNVSDRAGRT--------------------ALHHAAFSGHGEMVKLLLSRGANINAF 169
Query: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
D + R + +H AA ++EV + L+ HGA+V +DK PLH AAS G + + L+
Sbjct: 170 DKKDRRA--IHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227
Query: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL 951
+N + + TPLH A G+ + L+ GA KN++G TPL A A AL
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL 287
Query: 952 LIDAM 956
++ +
Sbjct: 288 CLELL 292
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 239 bits (609), Expect = 2e-62
Identities = 228/802 (28%), Positives = 346/802 (43%), Gaps = 119/802 (14%)
Query: 206 NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVV 265
+VN D K +PLH AA G +++E L+ GA V+A+D+ L PLH A + E V
Sbjct: 8 DVNTLD--SEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAV 65
Query: 266 SLLLCQGADPNARD-NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADP 324
+L+ AD NARD NW TPLH AA + V++ + N+ + G++AL
Sbjct: 66 QVLIKHSADVNARDKNWQ-TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH---- 120
Query: 325 SAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI 384
AA +G+ E ++ LL N +A D + LH AA + +
Sbjct: 121 ----------------HAALNGHVE-MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDV 163
Query: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK----------------HGACV 428
V LL+ HGA+V KDK G PLH A S G V + LL H AC
Sbjct: 164 VALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACY 223
Query: 429 NAMDLW-----------------QFTPLHEAASKNRVEVC-SLLLSHGADPTLVNCHGKS 470
N D FTPLH AA+ +C LL+++GAD + + GKS
Sbjct: 224 NGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKS 283
Query: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
+ M + R T + +L+Q E D + T LH A
Sbjct: 284 PLHMT---AVHGRFT---RSQTLIQNGGEIDCV---------------DKDGNTPLHVAA 322
Query: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
H + + L GA+ + M PLH+AA AH+D L G +++ D
Sbjct: 323 RYGH---ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Query: 591 GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPI 645
G+T LH AA G+++ +LL S G+D G + AA ++ +++ +
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439
Query: 646 -RTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLL 704
T D L + A D++ K + + + N +LE A +E+LL
Sbjct: 440 NETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA-----TLCLEFLL 494
Query: 705 HHGADVHAKDKGGLVPLHNACSYGHYEVAELLV-RHGASVNVADLWKF-TPLHEAAAKGK 762
+ A+ +DK G +H A +YGH + ELL+ R + +D +PLH AA G
Sbjct: 495 QNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGH 554
Query: 763 YEICKLLLKHGADPTKKNRDGNTPLDLVK-EGDTDIQDLLRGDAALL---DAAKKG---- 814
++ ++LL+ D ++ G T LDL +G T+ + L A + D K
Sbjct: 555 HQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLH 614
Query: 815 ---------CLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864
CL + ++ PE ++ +D +G+ TPL LA Y +++ LLE A+V+
Sbjct: 615 ASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVD 672
Query: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924
D G LH GH + +L++ + D TPLH AA +G + LL
Sbjct: 673 TVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ 732
Query: 925 HG---ADPTMKNQEGQTPLDLA 943
D K+ +G TPL A
Sbjct: 733 MALSEEDCCFKDNQGYTPLHWA 754
Score = 237 bits (605), Expect = 5e-62
Identities = 226/727 (31%), Positives = 323/727 (44%), Gaps = 90/727 (12%)
Query: 235 LLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGK 294
L+ +V+ D PLH A G AE++ LL+ GA NA+DN TPLH A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 295 IDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMAL 354
+ VL++H AD N R+ + ++ L +A + KAV E ++ L
Sbjct: 62 EEAVQVLIKHSADVNARDKNWQTPLHVAAAN-KAVKCAEV----------------IIPL 104
Query: 355 LTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGH 414
L+ +NV SD T LH AA V +V LLL GA+++A DK LH A GH
Sbjct: 105 LSSVNV----SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGH 160
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 474
+V LL+ HGA V D +TPLH AAS ++ V LL+ G + +N +G +A+ +
Sbjct: 161 LDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Query: 475 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE-TALHCAVASL 533
A + G V L N QP ++ T LH A AS
Sbjct: 221 AC-----------YNGQD-----------AVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
Query: 534 HPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQT 593
H ELL+ GA+VN ++KD +PLH+ A + L ++G +++ +D G T
Sbjct: 259 H--GALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNT 316
Query: 594 ALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYR 653
LH AA GH L + G+D A+ G + P+
Sbjct: 317 PLHVAARYGHELLINTLRTSGAD----------TAKCG-------IHSMFPLH------- 352
Query: 654 LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK 713
L A A K L S ++ D GR T LH AA V ++ L GAD H K
Sbjct: 353 -LAALNAHSDCCRKLLSSGFEIDTPDKFGR--TCLHAAAAGGNVECIKLLQSSGADFHKK 409
Query: 714 DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG 773
DK G PLH A + H+ E LV GA+VN D W T LH AAA + K +L +
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAA-SDMDRNKTILGNA 468
Query: 774 ADPTK--------KNRDGNTPLDLVKEGDTD--IQDLLRGDAALLDAAKKGCLARVQKLC 823
D ++ K ++ L+ + + D + I+D G ++ AA G ++ L
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRD-KEGYNSIHYAAAYGHRQCLELLL 527
Query: 824 TPENINCRDT-QGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882
N ++ G +PLHLAA + + E LL+ D++ +D+ G L AA GH
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587
Query: 883 VDIAALLIKYNTCVNATDK-WAFTPLHEAAQKGRTQLCALLLAHGADP---TMKNQEGQT 938
+ LI + D TPLH + G T LLL +P +K+ +GQT
Sbjct: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647
Query: 939 PLDLATA 945
PL LA A
Sbjct: 648 PLMLAVA 654
Score = 221 bits (563), Expect = 4e-57
Identities = 232/817 (28%), Positives = 348/817 (42%), Gaps = 118/817 (14%)
Query: 184 RELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L A G + V L++ A V KD G +PLH AA G+ +VV+HLL +G +
Sbjct: 150 RALHWAAYMGHLDVVALLINHGAEVTCKDKKGY--TPLHAAASNGQINVVKHLLNLGVEI 207
Query: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
+ G LH AC G VV+ L+ GA+ N +N +TPLH AA +C+ LL
Sbjct: 208 DEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
Query: 303 -QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVN 361
+GAD NI++ DGKS L + + G + + + L ++G E ++
Sbjct: 268 VNNGADVNIQSKDGKSPLHMT------AVHGRFTRSQTL--IQNGGE-----------ID 308
Query: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
C DG +TPLH+AA Y ++ L GAD + PLH A H + L
Sbjct: 309 CVDKDG--NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366
Query: 422 LKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGAD-------------PTLVNCH- 467
L G ++ D + T LH AA+ VE LL S GAD NCH
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426
Query: 468 -------------------GKSAVDMAPTPELRERLTYEFKGHSLLQAAREA-DLAKVKK 507
G++A+ A ++ T H + A +L + +
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 486
Query: 508 TLALEII--NFKQPQSHE----TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMT- 560
TL LE + N P + ++H A A H +Q ELLL + + E++ T
Sbjct: 487 TLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGH---RQCLELLLERTNSGFEESDSGATK 543
Query: 561 -PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
PLH+AA H+ +EVL + ++ D G+TAL AA GH + L++ G+ SI
Sbjct: 544 SPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGA--SI 601
Query: 620 ISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS-QNVNCR 678
V+ +++ TP+ S ++ L L + ++ + + V+ +
Sbjct: 602 F--------------VKDNVTKRTPLHASVINGHTL------CLRLLLEIADNPEAVDVK 641
Query: 679 DLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVR 738
D +G+ TPL A Y + V LL A+V D G LH GH E ++L+
Sbjct: 642 DAKGQ--TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLE 699
Query: 739 HGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGA---DPTKKNRDGNTPLDLV--KEG 793
S+ D TPLH AAA+G LL+ D K+ G TPL
Sbjct: 700 QEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGN 759
Query: 794 DTDIQDLLRGDA--------------ALLDAAKKGCLARVQKLCTPENINCRDTQGRNST 839
+ I+ LL A+++ C + + ++CRD +GR T
Sbjct: 760 ENCIEVLLEQKCFRKFIGNPFTPLHCAIIND-HGNCASLLLGAIDSSIVSCRDDKGR--T 816
Query: 840 PLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC-VNA 898
PL AA +++E + LL H A VNA D G L AA G +L+ +
Sbjct: 817 PLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTV 876
Query: 899 TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQE 935
DK TPLH A KG + L+L D ++ N++
Sbjct: 877 KDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEK 913
Score = 220 bits (561), Expect = 6e-57
Identities = 228/791 (28%), Positives = 347/791 (43%), Gaps = 75/791 (9%)
Query: 204 AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAE 263
+A+VNA+D + +PLH AA E ++ + ++V+ D GG LH+A GH E
Sbjct: 72 SADVNARDKNWQ--TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
Query: 264 VVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLAD 323
+V+LLL +GA+ NA D + LH AA G +DV +L+ HGA+ ++ G + L A
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAA 189
Query: 324 PS-----AKAVLTGEYKKDEL-------LEAARSGNEEKLMALLTPLNVNCHASDGRKST 371
+ K +L + DE+ L A ++ ++ L N + + T
Sbjct: 190 SNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFT 249
Query: 372 PLHLAAGYNRVRI-VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
PLH AA + ++LL+ +GADV+ + K G PLH +G + ++ L+++G ++
Sbjct: 250 PLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDC 309
Query: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490
+D TPLH AA + + L + GAD H + +A
Sbjct: 310 VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLA-----------ALNA 358
Query: 491 HSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGAN 550
HS D + + EI + T LH A A + +LL GA+
Sbjct: 359 HS--------DCCRKLLSSGFEIDT--PDKFGRTCLHAAAAG---GNVECIKLLQSSGAD 405
Query: 551 VNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
++K+K TPLH AA H +E L GA +N D G+TALH AA A + + +
Sbjct: 406 FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAA-ASDMDRNKTI 464
Query: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQIL--SESTP-IRTSDVDYRLLEASKAGDLETVK 667
L D S + + + L +++ P IR + + A+ G + ++
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 668 QLCSSQNVNCRDLE-GRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726
L N + + G +PLH AA +E LL D+ +D+ G L A
Sbjct: 525 LLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAF 584
Query: 727 YGHYEVAELLVRHGASVNVAD-LWKFTPLHEAAAKGKYEICKLLLKHGADPTK---KNRD 782
GH E E L+ GAS+ V D + K TPLH + G +LLL+ +P K+
Sbjct: 585 KGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAK 644
Query: 783 GNTPLDLV--------------KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE-N 827
G TPL L KE + D D+L G AL G VQ L E +
Sbjct: 645 GQTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL-GCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 828 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG---ADVNAQDKGGLIPLHNAASYGHVD 884
I C+D++GR TPLH AA + LL+ D +D G PLH A G+ +
Sbjct: 704 ILCKDSRGR--TPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761
Query: 885 IAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM---KNQEGQTPLD 941
+L++ C FTPLH A CA LL D ++ ++ +G+TPL
Sbjct: 762 CIEVLLE-QKCFRKFIGNPFTPLHCAIINDHGN-CASLLLGAIDSSIVSCRDDKGRTPLR 819
Query: 942 LAT-ADDIRAL 951
A AD + L
Sbjct: 820 AAAFADHVECL 830
Score = 183 bits (464), Expect = 1e-45
Identities = 176/612 (28%), Positives = 258/612 (42%), Gaps = 85/612 (13%)
Query: 387 LLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKN 446
+L+ DV+ D PLH A G E+ ELL+ GA VNA D TPLH A +
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 447 RVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVK 506
E +L+ H AD VN K+ ++ H + AA +A
Sbjct: 61 SEEAVQVLIKHSAD---VNARDKN---------------WQTPLH--VAAANKAVKCAEV 100
Query: 507 KTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 566
L +N + TALH A + H ++ LLL KGAN+N +K LH AA
Sbjct: 101 IIPLLSSVNVSD-RGGRTALHHAALNGH---VEMVNLLLAKGANINAFDKKDRRALHWAA 156
Query: 567 ERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT 626
H DV+ +L HGA++ D G T LH AA G + + LL+ G + I++ G T
Sbjct: 157 YMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNT 216
Query: 627 AAQMG---------NEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNC 677
A + NE + + + P AS G L + + +VN
Sbjct: 217 ALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNI 276
Query: 678 RDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737
+ +G+ +PLH A + R + + L+ +G ++ DK G PLH A YGH + L
Sbjct: 277 QSKDGK--SPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLR 334
Query: 738 RHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTD 796
GA + PLH AA + C+ LL G + ++ G T L G+ +
Sbjct: 335 TSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVE 394
Query: 797 IQDLLRGDAALLDAAKKGCLARV---------------QKLCTPENINCRDTQGRNSTPL 841
LL+ A D KK R + T N+N D GR T L
Sbjct: 395 CIKLLQSSGA--DFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGR--TAL 450
Query: 842 HLAA-------------GYNNLE---------------VAEYLLEHGADVNAQDKGGLIP 873
H AA ++N E E+LL++ A+ + +DK G
Sbjct: 451 HYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNS 510
Query: 874 LHNAASYGHVDIAALLI-KYNTCVNATDKWAF-TPLHEAAQKGRTQLCALLLAHGADPTM 931
+H AA+YGH LL+ + N+ +D A +PLH AA G Q +LL D +
Sbjct: 511 IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDI 570
Query: 932 KNQEGQTPLDLA 943
++++G+T LDLA
Sbjct: 571 RDEKGRTALDLA 582
Score = 169 bits (429), Expect = 1e-41
Identities = 138/427 (32%), Positives = 204/427 (47%), Gaps = 58/427 (13%)
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
T LH AVAS + ++ ++L++ A+VN ++K++ TPLHVAA EV+ +
Sbjct: 51 TPLHRAVAS---RSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSS 107
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
+N D G+TALH AAL GH++ LLL+ G++ + +
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKK-------------------- 147
Query: 644 PIRTSDVDYRLLE-ASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701
D R L A+ G L+ V L + V C+D +G TPLH AA +++VV+
Sbjct: 148 -------DRRALHWAAYMGHLDVVALLINHGAEVTCKDKKG--YTPLHAAASNGQINVVK 198
Query: 702 YLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKG 761
+LL+ G ++ + G LH AC G V L+ +GA+VN + FTPLH AAA
Sbjct: 199 HLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
Query: 762 KYEIC-KLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQ 820
+C +LL+ +GAD +++DG +PL + A G R Q
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHM--------------------TAVHGRFTRSQ 298
Query: 821 KLC-TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAAS 879
L I+C D G +TPLH+AA Y + + L GAD + PLH AA
Sbjct: 299 TLIQNGGEIDCVDKDG--NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
Query: 880 YGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTP 939
H D L+ ++ DK+ T LH AA G + LL + GAD K++ G+TP
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
Query: 940 LDLATAD 946
L A A+
Sbjct: 417 LHYAAAN 423
Score = 127 bits (318), Expect = 9e-29
Identities = 90/286 (31%), Positives = 135/286 (47%), Gaps = 25/286 (8%)
Query: 672 SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYE 731
+++VN D E R TPLH AA ++E L+ GA V+AKD L PLH A + E
Sbjct: 6 TEDVNTLDSEKR--TPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEE 63
Query: 732 VAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD-LV 790
++L++H A VN D TPLH AAA + ++++ + +R G T L
Sbjct: 64 AVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAA 123
Query: 791 KEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNL 850
G ++ +LL A NIN D + R + LH AA +L
Sbjct: 124 LNGHVEMVNLLLAKGA--------------------NINAFDKKDRRA--LHWAAYMGHL 161
Query: 851 EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEA 910
+V L+ HGA+V +DK G PLH AAS G +++ L+ ++ + + T LH A
Sbjct: 162 DVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIA 221
Query: 911 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAM 956
G+ + L+ +GA+ N G TPL A A AL ++ +
Sbjct: 222 CYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELL 267
Score = 112 bits (280), Expect = 2e-24
Identities = 78/244 (31%), Positives = 107/244 (43%), Gaps = 54/244 (22%)
Query: 703 LLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGK 762
L+H DV+ D PLH A G E+ ELL+ GA VN D TPLH A A
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61
Query: 763 YEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKL 822
E ++L+KH AD
Sbjct: 62 EEAVQVLIKHSAD----------------------------------------------- 74
Query: 823 CTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882
+N RD + TPLH+AA ++ AE ++ + VN D+GG LH+AA GH
Sbjct: 75 -----VNARDKNWQ--TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGH 127
Query: 883 VDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942
V++ LL+ +NA DK LH AA G + ALL+ HGA+ T K+++G TPL
Sbjct: 128 VEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHA 187
Query: 943 ATAD 946
A ++
Sbjct: 188 AASN 191
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 227 bits (578), Expect = 7e-59
Identities = 248/862 (28%), Positives = 355/862 (41%), Gaps = 142/862 (16%)
Query: 186 LLEACRNGDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
L++A + DV V+ L+ N+N D R +PLH AA G +++ LL GANV+A
Sbjct: 12 LVQAIFSRDVEEVRSLLSQKENINVLDQERR--TPLHAAAYVGDVPILQLLLMSGANVNA 69
Query: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
+D L PLH A + + +V+ LLL AD NARD TPLH AA L
Sbjct: 70 KDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPL 129
Query: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
+ N+ + G+SAL A SG+ E + LL + +
Sbjct: 130 LSSLNVADRSGRSALH--------------------HAVHSGHLETVNLLLNK-GASLNV 168
Query: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
D ++ PLH AA + +++LL+ GAD+ KD+ G LH A + G EV + LL+
Sbjct: 169 CDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRM 228
Query: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484
GA ++ + + T LH A + V L++ GA+ N G + + +A L
Sbjct: 229 GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAV-STNGAL 287
Query: 485 TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELL 544
E L AD +N+ Q + ++ LH +A++H + + +++L
Sbjct: 288 CLE------LLVNNGAD------------VNY-QSKEGKSPLH--MAAIHGRFTR-SQIL 325
Query: 545 LRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHL 604
++ G+ ++ +K TPLHVAA H ++ L +GA LH A L G
Sbjct: 326 IQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFS 385
Query: 605 QTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLE 664
CR LLS G SI+S + NE V
Sbjct: 386 DCCRKLLSSGQLYSIVS-------SLSNEHV----------------------------- 409
Query: 665 TVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA 724
L + ++N D GR T LH AA V + LL GAD+ +DK G PLH A
Sbjct: 410 ----LSAGFDINTPDNLGR--TCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYA 463
Query: 725 CSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYE-------------------- 764
+ G Y+ A LV GA VN AD +PLH AAA Y
Sbjct: 464 AANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKE 523
Query: 765 --------ICKLLLKHGADPTKKNRDGNTP------------LDLVKEGD----TDIQDL 800
+ LL +GADP+ ++R G T L+L+ E D++
Sbjct: 524 SRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVEST 583
Query: 801 LRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 860
+ L A C A T N++ RD +GR T L LA + E E L HG
Sbjct: 584 IPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGR--TALFLATERGSTECVEVLTAHG 641
Query: 861 ADVNAQD-KGGLIPLHNAASYGHVDIAALLIKYNTCVNAT---DKWAFTPLHEAAQKGRT 916
A ++ K PLH AA+ GH D LLI + T D + TPL A G
Sbjct: 642 ASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHV 701
Query: 917 QLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTC--FKPQATVVSA 974
LLL G+ + G+T L L + +A C FK + + A
Sbjct: 702 DCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLA 761
Query: 975 SLIS-PASTPSCLSAASSIDNL 995
S A + L AA S D L
Sbjct: 762 SACGHTAVLRTLLQAALSTDPL 783
Score = 204 bits (519), Expect = 5e-52
Identities = 261/962 (27%), Positives = 374/962 (38%), Gaps = 210/962 (21%)
Query: 193 GDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLI 251
G + +K LV A++ KD G LH AA G+ +VV++LL+MGA + + G
Sbjct: 184 GHLEVLKLLVARGADLGCKDRKGY--GLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNT 241
Query: 252 PLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL-QHGADPNI 310
LH AC G V L+ GA+ N ++ +TPLH AA+ +C+ LL +GAD N
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 311 RNTDGKSALDLADPSAKAVLTGEYKKDELL-------------------EAARSGNEEKL 351
++ +GKS L +A + G + + ++L AAR G+E +
Sbjct: 302 QSKEGKSPLHMA------AIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLI 355
Query: 352 MALLT--------------PLNV------------------------------------N 361
L+T PL++ +
Sbjct: 356 STLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFD 415
Query: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
+ D T LH AA V + LLL GAD+ +DK G PLH A + G Y+ L
Sbjct: 416 INTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTL 475
Query: 422 LKHGACVNAMDLWQFTPLHEAASKN---RVE-------------------------VCSL 453
+ GA VN D +PLH AA+ + R E
Sbjct: 476 VTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
Query: 454 LLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGH-------------SLLQAAREA 500
LL +GADP+L + G +AV A R+ L + S L A
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 501 DLAKVKKTLALEIINFK-QPQSHETALHCAVASLHPKRKQVTELLLRKGAN--VNEKNKD 557
+ KTLA ++N + TAL A + E+L GA+ + E+ +
Sbjct: 596 GHCEALKTLAETLVNLDVRDHKGRTALFLATER---GSTECVEVLTAHGASALIKERKRK 652
Query: 558 FMTPLHVAAERAHNDVMEVLHKHGAKMN---ALDTLGQTALHRAALAGHLQTCRLLLSYG 614
+ TPLH AA H D + +L G + + +D GQT L A + GH+ LLL G
Sbjct: 653 W-TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711
Query: 615 SDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQN 674
S L+G TA G + G + + L
Sbjct: 712 STADAADLRGRTALHRG--------------------------AVTGCEDCLAALLDHDA 745
Query: 675 -VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKG----GLVPLHNACSYGH 729
V CRD +GR TP+H A+ +V+ LL D G G P+H A GH
Sbjct: 746 FVLCRDFKGR--TPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGH 803
Query: 730 YEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD--GNTPL 787
+ ELL+ H + + + FTPLH A + ++LL +RD G TPL
Sbjct: 804 EDCLELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPL 862
Query: 788 DLVKEGD--TDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAA 845
D + ++ LL+ A +N D GR T L AA
Sbjct: 863 HAAAFADNVSGLRMLLQHQA---------------------EVNATDHTGR--TALMTAA 899
Query: 846 GYNNLEVAEYLLEHG-ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT---CVNATDK 901
E+LL G AD+ D+ LH A S GH A +++ +NAT+
Sbjct: 900 ENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNS 959
Query: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD-----DIRALLIDAM 956
PLH AA+ G + LL+HGA ++EG TP LA A D AL++ M
Sbjct: 960 ALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA-LACAPNKDVADCLALILSTM 1018
Query: 957 PPEALPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAELAVGGASNAGDGAAG 1016
P F P+ V S S + +C AA+ G L A S GA G
Sbjct: 1019 KP------FPPKDAV---SPFSFSLLKNCSIAAAKTVGGCGALPHGASCPYSQERPGAIG 1069
Query: 1017 TE 1018
+
Sbjct: 1070 LD 1071
Score = 40.8 bits (94), Expect = 0.009
Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLL---QMGANV 242
L+ A NG + V+ L+ + + K++ LH A G + +L Q +
Sbjct: 895 LMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLI 954
Query: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
+A + +PLH A G A VV LL GA A D +TP A + C+ L+
Sbjct: 955 NATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALI 1014
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 204 bits (518), Expect = 6e-52
Identities = 255/882 (28%), Positives = 368/882 (41%), Gaps = 160/882 (18%)
Query: 179 VSGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237
+ G + L+ A G V VK L+ A+VNA+ G ++ L +A G DVV+ LL+
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG--NTALTYACAGGYVDVVKVLLE 355
Query: 238 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKID 296
GA++ ++ G PL A S GH EV LLL GA N N + + L A KG ++
Sbjct: 356 SGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLE 415
Query: 297 VCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDE----LLEAARSGNEEKLM 352
+ LL+ GAD E+K DE L+EA G+ E
Sbjct: 416 MVRFLLEAGADQ------------------------EHKTDEMHTALMEACMDGHVEVAR 451
Query: 353 ALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 411
LL + VN A +PL LAA V + LL++ GA + + G PL A
Sbjct: 452 LLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAR 509
Query: 412 YGHYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
GH E+ LLL GA +NA + Q T L A +EV L+ GAD L C
Sbjct: 510 EGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL-GC---- 564
Query: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
TP L++AA+E L VK LA + +TAL A
Sbjct: 565 -----STP--------------LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605
Query: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
+ H V ++LL+ GA++ +++ TPL AA H ++ L GA +N
Sbjct: 606 ENGH---TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
Query: 591 G-QTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAV--------QQ 637
T L A GHL LLL++G+DP+ G T AA+ G+ +V
Sbjct: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNN 722
Query: 638 ILSESTPIRTS------DVDYRLLEASKAGDLETVKQ--------LCSSQNVNCRDLEGR 683
+LS P T D++ +A + Q + ++ + + + GR
Sbjct: 723 LLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGR 782
Query: 684 HS----TPLH-FAAGYNR---------VSVVEYL-LHHGADVHAKDKGGL-VPLHNACSY 727
S TP H AA ++ +S L ++ D+ A+ + L AC+
Sbjct: 783 ASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAG 842
Query: 728 GHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGAD-PTKKNRDGNTP 786
GH E+ + L+ GAS+ D FTPL AA G + ++LL +GAD + R +TP
Sbjct: 843 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902
Query: 787 LDLV-KEGDTDIQDLL--RG---------DAALLDAAKKGCLARVQK--LCTPENINCRD 832
L L G ++ +LL RG D L A G + K L IN R
Sbjct: 903 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
Query: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-------------------------- 866
+PL LAA + + LL+ G+D+NAQ
Sbjct: 963 GSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD 1022
Query: 867 --------DKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDKWAFTPLHEAAQKGRT 916
K GL PL AAS G+ ++ +L+ VNA T L AA KG
Sbjct: 1023 RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHY 1082
Query: 917 QLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
+ C LL+ GA ++N++G TPL LA D+ LL+ A
Sbjct: 1083 KFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1124
Score = 202 bits (514), Expect = 2e-51
Identities = 250/914 (27%), Positives = 364/914 (39%), Gaps = 167/914 (18%)
Query: 184 RELLEACRNGDVSRVKRL-VDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L EAC GDV+ V++L ++ +VN G S L A G ++ + LL M ANV
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEGE--SLLCLACSAGYYELAQVLLAMHANV 293
Query: 243 HARD-DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
R G + PL A + GH ++V LLL AD NA+ + T L A G +DV VL
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 302 LQHGADPNIRNTDGKSALDLADPS-----AKAVL---------TGEYKKDELLEAARSGN 347
L+ GA N +G + L A + A+ +L + E+K+ L A G+
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
Query: 348 EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 407
E + LL H +D T L A V + +LLL GA V+ PL
Sbjct: 414 LEMVRFLLEAGADQEHKTD-EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
Query: 408 NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCH 467
A GH E+ LL++ GA + ++ +TPL EAA + E+ +LLL GA+ +N
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGAN---INAQ 529
Query: 468 GK----SAVDMAPTPELRERLTYEFKGHS---------LLQAAREADLAKVKKTLALEII 514
+ +A+ +A E + K + L++AA+E L VK LA
Sbjct: 530 TEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGAN 589
Query: 515 NFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH---- 570
+ +TAL A + H V ++LL+ GA++ +++ TPL AA H
Sbjct: 590 VHATTATGDTALTYACENGHT---DVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 571 ----------------ND--------------VMEVLHKHGAKMNALDTLGQTALHRAAL 600
ND V+E+L HGA G T L AA
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706
Query: 601 AGHLQTCRLLLSYGSD------PSIISLQGFT-----AAQMGNEAVQQIL---------- 639
GH LL Y ++ P + L + A ++ +A+ ++
Sbjct: 707 GGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPA 766
Query: 640 --SESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDL----------------- 680
+ + PIR V R S + Q +
Sbjct: 767 NVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDA 826
Query: 681 --EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVR 738
E H T L A +V+ LL GA + +DK G PL A + GH V E+L+
Sbjct: 827 QTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Query: 739 HGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--T 795
+GA + ++ K TPL A + G+ E+ +LLL GA+ +N TPL L G
Sbjct: 887 NGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVN 946
Query: 796 DIQDLLR-------------GDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPL 841
I+ LL G + L+ AA G A V+ L +IN + RN T L
Sbjct: 947 IIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TAL 1005
Query: 842 HLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT-- 899
LA EV LL+ A+V + K GL PL AAS G+ ++ +L+ VNA
Sbjct: 1006 TLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPV 1065
Query: 900 ---------------------------------DKWAFTPLHEAAQKGRTQLCALLLAHG 926
+K TPL AA G + LL+ G
Sbjct: 1066 PSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAG 1125
Query: 927 ADPTMKNQEGQTPL 940
AD + TPL
Sbjct: 1126 ADVDAADNRKITPL 1139
Score = 194 bits (494), Expect = 4e-49
Identities = 212/796 (26%), Positives = 331/796 (41%), Gaps = 136/796 (17%)
Query: 186 LLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
L+EAC +G V + L+D+ A VN A SPL AA G ++ L++ GA++
Sbjct: 438 LMEACMDGHVEVARLLLDSGAQVNMP--ADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR-DNWNYTPLHEAAIKGKIDVCIVLLQ 303
+D G PL A GH E+V+LLL QGA+ NA+ + T L A G ++V L++
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 304 HGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCH 363
GAD L + P L+EAA+ G+ E L+ L N H
Sbjct: 556 AGADIE---------LGCSTP--------------LMEAAQEGHLE-LVKYLLAAGANVH 591
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
A+ T L A + +LLQ GAD+ + +GG PL A GH + L+
Sbjct: 592 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 424 HGACVNAMDLWQ-FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD--------- 473
GA VN T L A + + V LLL+HGADPT G + +
Sbjct: 652 KGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTS 711
Query: 474 -------------MAPTPELRERLTYEFKGHSLLQAAR---------------EADLAKV 505
AP P++ + H L +A R + A V
Sbjct: 712 VVCYLLDYPNNLLSAPPPDVTQLTP---PSHDLNRAPRVPVQALPMVVPPQEPDKPPANV 768
Query: 506 KKTLAL--EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV-----------N 552
TL + + ++ + T H AS+ + ++ A +
Sbjct: 769 ATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQT 828
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
E N D T L +A H ++++ L + GA + D G T L AA AGH+ +LL
Sbjct: 829 ESNHD--TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 886
Query: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672
G+D E+ RT D L + +G + V +L +
Sbjct: 887 NGAD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVELLLA 920
Query: 673 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730
+ N TPL AA V++++ LL+ GA+++++ K G+ PL A GH
Sbjct: 921 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 980
Query: 731 EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+LL+ G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 981 AAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL-- 1038
Query: 790 VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847
++AA G A V ++ + ++N T L +AA
Sbjct: 1039 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1079
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
+ + E L+ GA ++ ++K G PL AA+ GH+D+ LL++ V+A D TPL
Sbjct: 1080 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Query: 908 HEAAQKGRTQLCALLL 923
A +KG ++ L+
Sbjct: 1140 MAAFRKGHVKVVRYLV 1155
Score = 177 bits (449), Expect = 6e-44
Identities = 208/747 (27%), Positives = 313/747 (41%), Gaps = 108/747 (14%)
Query: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
+C+ A + + NA + N + L EA +G ++ LL G N +G
Sbjct: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
Query: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS--TPL 373
+S L LA + G Y+ ++L A + E++ G K TPL
Sbjct: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
Query: 374 HLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDL 433
AA V+IV+LLL H ADV+A+ G L AC+ G+ +V ++LL+ GA + +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 434 WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL 493
TPL EA S VEV LLL +GA +N H EFK +L
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAG---INTHSN-----------------EFKESAL 405
Query: 494 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 553
A + L V+ L + TAL A H +V LLL GA VN
Sbjct: 406 TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH---VEVARLLLDSGAQVNM 462
Query: 554 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613
F +PL +AA H ++ +L + GA + ++ G T L AA GH + LLL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 614 GSDPSIISLQ----GFTAAQMGN--EAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667
G++ + + + T A G E ++ I L+EA++ G LE VK
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG-CSTPLMEAAQEGHLELVK 581
Query: 668 Q-LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726
L + NV+ G T L +A V + LL GAD+ + +GG PL A
Sbjct: 582 YLLAAGANVHATTATG--DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 727 YGHYEVAELLVRHGASVNVADLWK-FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNT 785
GH + L+ GA+VN T L A A G + +LLL HGADPT + +DG+T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Query: 786 PL-DLVKEGDTDI--------QDLLRG----------DAALLDAAKKGCLARVQKLCTPE 826
L + K G T + +LL + L+ A + + + + P+
Sbjct: 700 MLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQ 759
Query: 827 N-------------INCRDTQGR----NSTPLH-LAAGYNNLEV----------AEYLLE 858
I + GR ++TP H +AA + + A +
Sbjct: 760 EPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIY 819
Query: 859 HGADVNAQDKGGL-IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQ 917
D++AQ + L A + GH ++ L++ + DK FTPL AA G
Sbjct: 820 PAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVG 879
Query: 918 LCALLLAHGADPTMKNQEGQ-TPLDLA 943
+ +LL +GAD +++ + TPL LA
Sbjct: 880 VVEILLDNGADIEAQSERTKDTPLSLA 906
Score = 154 bits (388), Expect = 7e-37
Identities = 196/725 (27%), Positives = 291/725 (40%), Gaps = 126/725 (17%)
Query: 171 GPGTGVPAVSGALRE--LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGR 228
G G + A + +E L AC G + L+ A D+ S+PL AA G
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAG----ADIELGCSTPLMEAAQEGH 576
Query: 229 KDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHE 288
++V++LL GANVHA G L AC GH +V +LL GAD TPL +
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 289 AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 348
AA G + L+ GA+ N R T + N+
Sbjct: 637 AARAGHVCTVQFLISKGANVN-RTT-------------------------------ANND 664
Query: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
+++ LA + +V+LLL HGAD + K G L
Sbjct: 665 HTVLS---------------------LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
Query: 409 ACSYGHYEVTELLLKHG---ACVNAMDLWQFT-PLHEAASKNRVEVCSL-LLSHGADPTL 463
A GH V LL + D+ Q T P H+ RV V +L ++ +P
Sbjct: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP-- 761
Query: 464 VNCHGKSAVDMAPTPELRERL------------TYEFKGHSLLQAAREADLAKVKKTLAL 511
K ++A T +R + T+ S+ Q + + L
Sbjct: 762 ----DKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAA-SISQPQTPTPSPIISPSAML 816
Query: 512 EI-----INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 566
I I+ + +H+TAL A A H +++ + LL +GA++ ++K TPL +AA
Sbjct: 817 PIYPAIDIDAQTESNHDTALTLACAGGH---EELVQTLLERGASIEHRDKKGFTPLILAA 873
Query: 567 ERAHNDVMEVLHKHGAKMNA-LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGF 625
H V+E+L +GA + A + T L A G + LLL+ G++ ++ +
Sbjct: 874 TAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 933
Query: 626 T----AAQMGNEAVQQILSESTPIRTSDVDYR-----LLEASKAGDLETVKQLCSSQNVN 676
T AA G + +IL + S + L+ A+ G VK L +
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993
Query: 677 CRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELL 736
+E +T L A R VV LL A+V + K GL PL A S G+ EV +L
Sbjct: 994 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053
Query: 737 VRHGASVNVADL--WKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-G 793
+ GA VN + + T L AA KG Y+ C+LL+ GA +N+ GNTPL L G
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGG 1113
Query: 794 DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVA 853
D+ LL A +DAA R TPL A +++V
Sbjct: 1114 HLDVVQLLVQAGADVDAA----------------------DNRKITPLMAAFRKGHVKVV 1151
Query: 854 EYLLE 858
YL++
Sbjct: 1152 RYLVK 1156
Score = 133 bits (335), Expect = 1e-30
Identities = 169/605 (27%), Positives = 256/605 (42%), Gaps = 57/605 (9%)
Query: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN 465
L ACS G LL G VN + L A S E+ +LL+ A+
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 466 CHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETA 525
G D+ P L+ AA + VK LA + Q + TA
Sbjct: 298 IKG----DITP----------------LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
Query: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
L A A + V ++LL GA++ + N++ TPL A H +V +L ++GA +N
Sbjct: 338 LTYACAGGYV---DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394
Query: 586 A-LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM----GNEAVQQILS 640
+ ++AL A GHL+ R LL G+D + + TA G+ V ++L
Sbjct: 395 THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 454
Query: 641 ES---TPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRV 697
+S + + L A+ G +E + L + + ++ TPL AA
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
Query: 698 SVVEYLLHHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
+V LL GA+++A+ ++ L AC G EVA+ L++ GA + +L TPL E
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLME 570
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR------------G 803
AA +G E+ K LL GA+ G+T L E G TD+ D+L G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 804 DAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
L+ AA+ G + VQ L + N+N R T + T L LA +L V E LL HGAD
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGAD 689
Query: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKY-NTCVNA--TDKWAFT-PLHEAAQKGRTQL 918
+ K G L AA GH + L+ Y N ++A D T P H+ + R +
Sbjct: 690 PTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPV 749
Query: 919 CAL-LLAHGADPTMKNQEGQTPLDLAT-ADDIRALLIDAMPPEALPTCFKPQATVVSASL 976
AL ++ +P T L + A RA + P ++ T + +
Sbjct: 750 QALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPI 809
Query: 977 ISPAS 981
ISP++
Sbjct: 810 ISPSA 814
Score = 126 bits (317), Expect = 1e-28
Identities = 156/558 (27%), Positives = 224/558 (40%), Gaps = 91/558 (16%)
Query: 181 GALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
G L++A R G V V+ L+ ANVN + A + L A G VVE LL G
Sbjct: 629 GGRTPLMKAARAGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHG 687
Query: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLC----------------------------- 270
A+ R G L A GH VV LL
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRV 747
Query: 271 -----------QGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSAL 319
Q D + P+ A+ G+ H +I +
Sbjct: 748 PVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPS 807
Query: 320 DLADPSAKAVL--------TGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKST 371
+ PSA + E D L A +G E+L+ L + D + T
Sbjct: 808 PIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFT 867
Query: 372 PLHLAAGYNRVRIVQLLLQHGADVHAK-DKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
PL LAA V +V++LL +GAD+ A+ ++ PL ACS G EV ELLL GA
Sbjct: 868 PLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEH 927
Query: 431 MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKG 490
++ +TPL AAS V + +LL+ GA+ +N S + ++P
Sbjct: 928 RNVSDYTPLSLAASGGYVNIIKILLNAGAE---INSRTGSKLGISP-------------- 970
Query: 491 HSLLQAAREADLAKVKKTLAL-EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
L+ AA A VK L + IN + + TAL A R +V LLL + A
Sbjct: 971 --LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLA---CFQGRTEVVSLLLDRKA 1025
Query: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTC 607
NV + K +TPL AA + +V VL GA +NA + + TAL AA GH + C
Sbjct: 1026 NVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC 1085
Query: 608 RLLLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYR-------LLE 656
LL+ G+ + + +G T AA G+ V Q+L ++ +DVD L+
Sbjct: 1086 ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA----GADVDAADNRKITPLMA 1141
Query: 657 ASKAGDLETVKQLCSSQN 674
A + G ++ V+ L N
Sbjct: 1142 AFRKGHVKVVRYLVKEVN 1159
Score = 119 bits (297), Expect = 3e-26
Identities = 117/378 (30%), Positives = 173/378 (45%), Gaps = 31/378 (8%)
Query: 103 PVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSST 162
P P ++ A P + S + + S++PT S ++S S P ++P + + S
Sbjct: 758 PQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQP-----QTPTPSPIISP 812
Query: 163 APLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLH 221
+ + P S L AC G V+ L++ A++ +D G +PL
Sbjct: 813 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLI 870
Query: 222 FAAGFGRKDVVEHLLQMGANVHARDDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDN 280
AA G VVE LL GA++ A+ + PL ACS G EVV LLL +GA+ R+
Sbjct: 871 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 930
Query: 281 WNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELL 340
+YTPL AA G +++ +LL GA+ N R T K + L+
Sbjct: 931 SDYTPLSLAASGGYVNIIKILLNAGAEINSR-TGSKLGI-----------------SPLM 972
Query: 341 EAARSGNEEKLMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKD 399
AA +G+ + LL ++N R +T L LA R +V LLL A+V +
Sbjct: 973 LAAMNGHTAAVKLLLDMGSDINAQIETNR-NTALTLACFQGRTEVVSLLLDRKANVEHRA 1031
Query: 400 KGGLVPLHNACSYGHYEVTELLLKHGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSH 457
K GL PL A S G+ EV +LL GA VNA + + T L AA K + C LL+
Sbjct: 1032 KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGR 1091
Query: 458 GADPTLVNCHGKSAVDMA 475
GA + N G + + +A
Sbjct: 1092 GAHIDVRNKKGNTPLWLA 1109
Score = 81.3 bits (199), Expect = 6e-15
Identities = 80/257 (31%), Positives = 116/257 (45%), Gaps = 47/257 (18%)
Query: 155 EAAGVSSTAPLGPGAAG-----------PGTGVPAVSGA---LRELLEACRNGDVSRVKR 200
E VS PL A+G G + + +G+ + L+ A NG + VK
Sbjct: 926 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 985
Query: 201 LVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259
L+D +++NA+ R ++ L A GR +VV LL ANV R GL PL A S
Sbjct: 986 LLDMGSDINAQIETNRNTA-LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1044
Query: 260 GHAEVVSLLLCQGAD------PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 313
G+AEV +LL +GAD P++RD T L AA KG C +L+ GA ++RN
Sbjct: 1045 GYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVRNK 1100
Query: 314 DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 373
G + L L A +G ++ LL + A+D RK TPL
Sbjct: 1101 KGNTPLWL---------------------AANGGHLDVVQLLVQAGADVDAADNRKITPL 1139
Query: 374 HLAAGYNRVRIVQLLLQ 390
A V++V+ L++
Sbjct: 1140 MAAFRKGHVKVVRYLVK 1156
Score = 38.5 bits (88), Expect = 0.043
Identities = 42/165 (25%), Positives = 61/165 (36%), Gaps = 27/165 (16%)
Query: 14 HQQQLQPAPGASAPPPPP------PPP----LSPGLAPGTTPASPTASGLAPFASPRHGL 63
H Q QP S P PP PPP P LA + P + ++ + P+ +
Sbjct: 1854 HSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPM 1913
Query: 64 ALPEGDGSRDPPD-RPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAG 122
P+ + P RP P GT+ S +V SS A ++ N
Sbjct: 1914 GCPQPTPKMETPAIRP----PPHGTTAPHKNSA-----------SVQNSSVAVLSVNHI- 1957
Query: 123 SGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGP 167
++ PSS P++ S+ S A P A S+ P GP
Sbjct: 1958 KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGP 2002
Score = 37.7 bits (86), Expect = 0.074
Identities = 27/91 (29%), Positives = 39/91 (42%)
Query: 74 PPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSS 133
P P SP P S S + +A+P A S+ AG P + + SSSS
Sbjct: 1788 PVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSS 1847
Query: 134 SPTSSSSSSPSSPGSSLAESPEAAGVSSTAP 164
S +SS+ S+ P S+++ P S P
Sbjct: 1848 SGSSSAHSNQQQPPGSVSQEPRPPLQQSQVP 1878
Score = 32.0 bits (71), Expect = 4.1
Identities = 33/149 (22%), Positives = 52/149 (34%)
Query: 18 LQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDR 77
L PA ++P P P S + G+ S + +P + + G + P
Sbjct: 1681 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS 1740
Query: 78 PRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTS 137
P + T ++ +T TV + ++A P +SPSS S P
Sbjct: 1741 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ 1800
Query: 138 SSSSSPSSPGSSLAESPEAAGVSSTAPLG 166
S +SP + SP SS G
Sbjct: 1801 PGGVSRNSPLDCGSASPNKVASSSEQEAG 1829
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 203 bits (517), Expect = 8e-52
Identities = 201/651 (30%), Positives = 287/651 (44%), Gaps = 96/651 (14%)
Query: 228 RKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLH 287
R+D + LL GA+V+ D G L NA G +VV+LL+ +GAD D +TPL
Sbjct: 524 REDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLT 583
Query: 288 EAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGN 347
AA +G V L+ GA+ N + DG +A L AA G+
Sbjct: 584 LAARQGHTKVVNCLIGCGANINHTDQDGWTA--------------------LRSAAWGGH 623
Query: 348 EEKLMALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
E + ALL + V+C +D R T L AA IV LLQHGA+V+ D G L
Sbjct: 624 TEVVSALLYAGVKVDCADADSR--TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
Query: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA-----ASKNRVEVCSLLLSHGADP 461
A GH E+ E LL HGA VN D+ T L A ASK V SLL+ GA+
Sbjct: 682 IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE- 740
Query: 462 TLVNCHGKSAVDMAPTPELRERLTYEFKGH-----SLLQAAREADLAKVKKTLALEIINF 516
VD + L ++GH LL+ + D
Sbjct: 741 ----------VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD--------------- 775
Query: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576
+ T L A + H V LL GA V+ + + T L +A+ + + +V+
Sbjct: 776 HTDNNGRTPLLAAASMGH---ASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Query: 577 LHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG----FTAAQMGN 632
L G N D G T LH AA GH C L+ G+ + I G A+Q G+
Sbjct: 833 LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
Query: 633 EAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCS-SQNVNCRDLEGRH 684
QIL E+ S++D R L A+ G + V+ L S +VNC+D +GR
Sbjct: 893 YDCVQILLEN----KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRP 948
Query: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN 744
+ L+ A N++++ EY L +GA+V A D G LH +C GH E+ ++L+ + A VN
Sbjct: 949 T--LYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVN 1006
Query: 745 VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLR- 802
AD K + L AA +G ++ +LL++HGA G T L + +EG D+ +L
Sbjct: 1007 AADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066
Query: 803 -----------GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLH 842
G A+ AAK G ++ L E G + +P+H
Sbjct: 1067 HGADPNHADQFGRTAMRVAAKNGHSQIIKLL---EKYGASSLNGCSPSPVH 1114
Score = 199 bits (505), Expect = 2e-50
Identities = 199/684 (29%), Positives = 299/684 (43%), Gaps = 68/684 (9%)
Query: 348 EEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLH 407
E++++ LL + ++ D R S + A R ++ LL +GA V+ D G L
Sbjct: 493 EQEVLQLLVKAGAHVNSEDDRTSCIVRQAL--EREDSIRTLLDNGASVNQCDSNGRTLLA 550
Query: 408 NACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCH 467
NA G +V LL+ GA + D TPL AA + +V + L+ GA+ +
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
G +A+ A E ++ +LL A + D A TAL
Sbjct: 611 GWTALRSAAWGGHTEVVS------ALLYAGVKVDCADADS---------------RTALR 649
Query: 528 CAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL 587
A H + + LL+ GA VN+ + + T L AA H +++E L HGA++N
Sbjct: 650 AAAWGGH---EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHE 706
Query: 588 DTLGQTALHRAALA-----GHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQI 638
D G+TAL AAL GH LL+ G++ G T AA G+ V +
Sbjct: 707 DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766
Query: 639 LSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHF 690
L E +DVD+ LL A+ G V L V+ D EGR T L
Sbjct: 767 LLEGG----ADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGR--TVLSI 820
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
A+ V VV LL G D + +D G PLH A GH + E L+ GA N D
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK-EGDTDIQDLLRGDAALLD 809
P A+ +G Y+ ++LL++ ++ ++ DG L + EG DI +LL A ++
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 810 AAKKG------CLARVQKLCTPE-------NINCRDTQGRNSTPLHLAAGYNNLEVAEYL 856
LA +L E N+ D +GR T LH++ ++E+ + L
Sbjct: 941 CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGR--TALHVSCWQGHMEMVQVL 998
Query: 857 LEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRT 916
+ + ADVNA D L +AA GHV + LLI++ V+ T T L AAQ+G
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
Query: 917 QLCALLLAHGADPTMKNQEGQTPLDLATADDIRAL--LIDAMPPEALPTCF-KPQATVVS 973
+ +LL HGADP +Q G+T + +A + + L++ +L C P T+
Sbjct: 1059 DVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQ 1118
Query: 974 ASLISPASTPSCLSAASSIDNLTG 997
L S +S L+ S+ TG
Sbjct: 1119 KPLQSLSSKVQSLTIKSNSSGSTG 1142
Score = 197 bits (501), Expect = 6e-50
Identities = 181/602 (30%), Positives = 268/602 (44%), Gaps = 61/602 (10%)
Query: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
L A +G + V LV A++ +D G +PL AA G VV L+ GAN++
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGH--TPLTLAARQGHTKVVNCLIGCGANINH 606
Query: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
D G L +A GH EVVS LL G + D + T L AA G D+ + LLQH
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666
Query: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNVNCH 363
GA+ N + +G++A L+ AA G+ E + LL VN
Sbjct: 667 GAEVNKADNEGRTA--------------------LIAAAYMGHREIVEHLLDHGAEVNHE 706
Query: 364 ASDGRKS---TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
DGR + L + A +V LL+ GA+V DK G+ PL A GH +V +L
Sbjct: 707 DVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDL 766
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LL+ GA V+ D TPL AAS V + LL GA ++ G++ + +
Sbjct: 767 LLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI------ 820
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQV 540
A+ + ++ V+ L + + + T LH A H + +
Sbjct: 821 ---------------ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH---RLI 862
Query: 541 TELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAAL 600
E L+ +GA NE + D P +A++ H D +++L ++ + ++ G+ AL AAL
Sbjct: 863 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAAL 922
Query: 601 AGHLQTCRLLLSYGSDPSIISLQG-----FTAAQMGNEAVQQILSESTPIRTSDVDYR-- 653
GH LL S+G+D + G A + + L + SD + R
Sbjct: 923 EGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
Query: 654 LLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
L + G +E V+ L + +VN D E R + L AA V VV+ L+ HGA V
Sbjct: 983 LHVSCWQGHMEMVQVLIAYHADVNAADNEKR--SALQSAAWQGHVKVVQLLIEHGAVVDH 1040
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
G L A GH +V ++L+ HGA N AD + T + AA G +I KLL K+
Sbjct: 1041 TCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Query: 773 GA 774
GA
Sbjct: 1101 GA 1102
Score = 193 bits (490), Expect = 1e-48
Identities = 191/680 (28%), Positives = 294/680 (43%), Gaps = 87/680 (12%)
Query: 263 EVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA 322
EV+ LL+ GA N+ D+ + +A + D LL +GA N +++G++ L
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLL--- 549
Query: 323 DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 382
AA SG+ + ++ LL + D TPL LAA
Sbjct: 550 -----------------ANAAYSGSLD-VVNLLVSRGADLEIEDAHGHTPLTLAARQGHT 591
Query: 383 RIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
++V L+ GA+++ D+ G L +A GH EV LL G V+ D T L A
Sbjct: 592 KVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAA 651
Query: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
A ++ LL HGA+ + G++A+ A RE + + LL E +
Sbjct: 652 AWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH------LLDHGAEVNH 705
Query: 503 AKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPL 562
V AL + P S A V LL+ +GA V+ +KD MTPL
Sbjct: 706 EDVDGRTALSVAALCVPASKGHA-------------SVVSLLIDRGAEVDHCDKDGMTPL 752
Query: 563 HVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISL 622
VAA H DV+++L + GA ++ D G+T L AA GH LL +G+
Sbjct: 753 LVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGA------- 805
Query: 623 QGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLE 681
AV I SE + L AS G++E V+ L + N RD
Sbjct: 806 -----------AVDSIDSEGRTV--------LSIASAQGNVEVVRTLLDRGLDENHRDDA 846
Query: 682 GRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA 741
G TPLH AA + E L+ GA + D G +P A GHY+ ++L+ + +
Sbjct: 847 G--WTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
Query: 742 SVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL------------ 789
+++ L AA +G +I +LL HGAD K+ DG L +
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 790 -VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCT-PENINCRDTQGRNSTPLHLAAGY 847
++ G G AL + +G + VQ L ++N D + R++ L AA
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSA--LQSAAWQ 1022
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
+++V + L+EHGA V+ G L AA GH+D+ +L+++ N D++ T +
Sbjct: 1023 GHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAM 1082
Query: 908 HEAAQKGRTQLCALLLAHGA 927
AA+ G +Q+ LL +GA
Sbjct: 1083 RVAAKNGHSQIIKLLEKYGA 1102
Score = 166 bits (419), Expect = 2e-40
Identities = 163/550 (29%), Positives = 249/550 (45%), Gaps = 48/550 (8%)
Query: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRER-LTYEFKGHSLLQAAREADLA 503
+ ++++ S LL G T + H A + ++ L +GH +L +
Sbjct: 386 QRKLDILSKLLVDGLGNTKILFHYSFAEWLLDVKHCTQKYLCNAAEGHRMLAMSYTCQAK 445
Query: 504 KVK----KTLALEIINFK-QPQSHETALHC---------AVASLHPKRKQVTELLLRKGA 549
+ + AL +IN Q ++ E AL ++++L PK ++V +LL++ GA
Sbjct: 446 NLTPLEAQEFALHLINSNLQLETAELALWMIWNGTPVRDSLSTLIPKEQEVLQLLVKAGA 505
Query: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
+VN ++ + A ER D + L +GA +N D+ G+T L AA +G L L
Sbjct: 506 HVNSEDDRTSCIVRQALER--EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNL 563
Query: 610 LLSYGSDPSIISLQGFT----AAQMGN-EAVQQILSESTPIRTSDVD--YRLLEASKAGD 662
L+S G+D I G T AA+ G+ + V ++ I +D D L A+ G
Sbjct: 564 LVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGH 623
Query: 663 LETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPL 721
E V L + V+C D + R T L AA +V LL HGA+V+ D G L
Sbjct: 624 TEVVSALLYAGVKVDCADADSR--TALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681
Query: 722 HNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA-----AAKGKYEICKLLLKHGADP 776
A GH E+ E L+ HGA VN D+ T L A A+KG + LL+ GA+
Sbjct: 682 IAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEV 741
Query: 777 TKKNRDGNTPLDLVK-EGDTDIQDLL------------RGDAALLDAAKKGCLARVQKLC 823
++DG TPL + EG D+ DLL G LL AA G + V L
Sbjct: 742 DHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLL 801
Query: 824 -TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882
++ D++GR T L +A+ N+EV LL+ G D N +D G PLH AA GH
Sbjct: 802 FWGAAVDSIDSEGR--TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 859
Query: 883 VDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDL 942
I LI+ N D P A+Q+G +LL + ++ + +G+ L +
Sbjct: 860 RLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRV 919
Query: 943 ATADDIRALL 952
A + R ++
Sbjct: 920 AALEGHRDIV 929
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 167 bits (424), Expect = 5e-41
Identities = 167/553 (30%), Positives = 241/553 (43%), Gaps = 60/553 (10%)
Query: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
+C+ A + + NA + N + L EA +G ++ LL G N +G
Sbjct: 209 SCALDEAAAALTRMRAESTANAGQSDNRS-LAEACSEGDVNAVRKLLIEGRSVNEHTEEG 267
Query: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKS--TPL 373
+S L LA + G Y+ ++L A + E++ G K TPL
Sbjct: 268 ESLLCLACSA------GYYELAQVLLAMHANVEDR----------------GIKGDITPL 305
Query: 374 HLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDL 433
AA V+IV+LLL H ADV+A+ G L AC+ G+ +V ++LL+ GA + +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 434 WQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSL 493
TPL EA S VEV LLL +GA +N H EFK +L
Sbjct: 366 NGHTPLMEAGSAGHVEVARLLLENGAG---INTHSN-----------------EFKESAL 405
Query: 494 LQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNE 553
A + L V+ L + TAL A H +V LLL GA VN
Sbjct: 406 TLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGH---VEVARLLLDSGAQVNM 462
Query: 554 KNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSY 613
F +PL +AA H ++ +L + GA + ++ G T L AA GH + LLL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 614 GSDPSIISLQ----GFTAAQMGN--EAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK 667
G++ + + + T A G E ++ I L+EA++ G LE VK
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG-CSTPLMEAAQEGHLELVK 581
Query: 668 Q-LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACS 726
L + NV+ G T L +A V + LL GAD+ + +GG PL A
Sbjct: 582 YLLAAGANVHATTATG--DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 727 YGHYEVAELLVRHGASVNVADLWK-FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNT 785
GH + L+ GA+VN T L A A G + +LLL HGADPT + +DG+T
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Query: 786 PL-DLVKEGDTDI 797
L + K G T +
Sbjct: 700 MLIEAAKGGHTSV 712
Score = 160 bits (405), Expect = 8e-39
Identities = 158/514 (30%), Positives = 228/514 (44%), Gaps = 51/514 (9%)
Query: 184 RELLEACRNGDVSRVKR-LVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L EAC GDV+ V++ L++ +VN G S L A G ++ + LL M ANV
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 293
Query: 243 HARD-DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
R G + PL A + GH ++V LLL AD NA+ + T L A G +DV VL
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNV 360
L+ GA N +G + L+EA +G+ E LL +
Sbjct: 354 LESGASIEDHNENGHT--------------------PLMEAGSAGHVEVARLLLENGAGI 393
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 394 NTHSNEFKESA-LTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 452
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LL GA VN +PL AA VE+ +LL+ GA VN G + + M E
Sbjct: 453 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPL-MEAAREG 511
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLA-----LEIINFKQPQSHETALHCAVASLHP 535
E + G A+ + + TLA LE+ +F + L C+ +
Sbjct: 512 HEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEA 571
Query: 536 KRK---QVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
++ ++ + LL GANV+ T L A E H DV +VL + GA + G+
Sbjct: 572 AQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631
Query: 593 TALHRAALAGHLQTCRLLLSYG---------SDPSIISLQGFTAAQMGNEAVQQIL---S 640
T L +AA AGH+ T + L+S G +D +++SL A G+ AV ++L
Sbjct: 632 TPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSL----ACAGGHLAVVELLLAHG 687
Query: 641 ESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQN 674
R D L+EA+K G V L N
Sbjct: 688 ADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPN 721
Score = 147 bits (370), Expect = 9e-35
Identities = 146/472 (30%), Positives = 214/472 (45%), Gaps = 30/472 (6%)
Query: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
SL +A E D+ V+K L +E + + +L C S ++ ++LL ANV
Sbjct: 237 SLAEACSEGDVNAVRKLL-IEGRSVNEHTEEGESLLCLACSAG--YYELAQVLLAMHANV 293
Query: 552 NEKN-KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
++ K +TPL AA H ++++L H A +NA + G TAL A G++ ++L
Sbjct: 294 EDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Query: 611 LSYGSDPSIISLQGFT----AAQMGNEAVQQILSES-TPIRTSDVDYR---LLEASKAGD 662
L G+ + G T A G+ V ++L E+ I T +++ L A G
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGH 413
Query: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
LE V+ L + + H T L A V V LL GA V+ PL
Sbjct: 414 LEMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 472
Query: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGAD---PTKK 779
A GH E+A LL+ GAS+ + +TPL EAA +G E+ LLL GA+ T++
Sbjct: 473 LAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEE 532
Query: 780 NRDGNTPL----------DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENIN 829
++ L D + + DI+ L L++AA++G L V+ L N
Sbjct: 533 TQETALTLACCGGFLEVADFLIKAGADIE--LGCSTPLMEAAQEGHLELVKYLLAA-GAN 589
Query: 830 CRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 889
T T L A + +VA+ LL+ GAD+ + +GG PL AA GHV L
Sbjct: 590 VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFL 649
Query: 890 IKYNTCVNATD-KWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
I VN T T L A G + LLLAHGADPT + ++G T L
Sbjct: 650 ISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
Score = 141 bits (355), Expect = 5e-33
Identities = 147/470 (31%), Positives = 207/470 (44%), Gaps = 68/470 (14%)
Query: 179 VSGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237
+ G + L+ A G V VK L+ A+VNA+ G ++ L +A G DVV+ LL+
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTG--NTALTYACAGGYVDVVKVLLE 355
Query: 238 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKID 296
GA++ ++ G PL A S GH EV LLL GA N N + + L A KG ++
Sbjct: 356 SGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLE 415
Query: 297 VCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDE----LLEAARSGNEEKLM 352
+ LL+ GAD E+K DE L+EA G+ E
Sbjct: 416 MVRFLLEAGADQ------------------------EHKTDEMHTALMEACMDGHVEVAR 451
Query: 353 ALL-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACS 411
LL + VN A +PL LAA V + LL++ GA + + G PL A
Sbjct: 452 LLLDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAR 509
Query: 412 YGHYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKS 470
GH E+ LLL GA +NA + Q T L A +EV L+ GAD L C
Sbjct: 510 EGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL-GC---- 564
Query: 471 AVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV 530
TP L++AA+E L VK LA + +TAL A
Sbjct: 565 -----STP--------------LMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYAC 605
Query: 531 ASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTL 590
+ H V ++LL+ GA++ +++ TPL AA H ++ L GA +N
Sbjct: 606 ENGH---TDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTAN 662
Query: 591 G-QTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAV 635
T L A GHL LLL++G+DP+ G T AA+ G+ +V
Sbjct: 663 NDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSV 712
Score = 131 bits (329), Expect = 5e-30
Identities = 149/510 (29%), Positives = 220/510 (43%), Gaps = 51/510 (10%)
Query: 406 LHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN 465
L ACS G LL G VN + L A S E+ +LL+ A+
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 466 CHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETA 525
G D+ P L+ AA + VK LA + Q + TA
Sbjct: 298 IKG----DITP----------------LMAAANGGHVKIVKLLLAHKADVNAQSSTGNTA 337
Query: 526 LHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
L A A + V ++LL GA++ + N++ TPL A H +V +L ++GA +N
Sbjct: 338 LTYACAGGYV---DVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394
Query: 586 A-LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM----GNEAVQQILS 640
+ ++AL A GHL+ R LL G+D + + TA G+ V ++L
Sbjct: 395 THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 454
Query: 641 ES---TPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRV 697
+S + + L A+ G +E + L + + ++ TPL AA
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGHVE-LAALLIERGASLEEVNDEGYTPLMEAAREGHE 513
Query: 698 SVVEYLLHHGADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
+V LL GA+++A+ ++ L AC G EVA+ L++ GA + +L TPL E
Sbjct: 514 EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI---ELGCSTPLME 570
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR------------G 803
AA +G E+ K LL GA+ G+T L E G TD+ D+L G
Sbjct: 571 AAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGG 630
Query: 804 DAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
L+ AA+ G + VQ L + N+N R T + T L LA +L V E LL HGAD
Sbjct: 631 RTPLMKAARAGHVCTVQFLISKGANVN-RTTANNDHTVLSLACAGGHLAVVELLLAHGAD 689
Query: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
+ K G L AA GH + L+ Y
Sbjct: 690 PTHRLKDGSTMLIEAAKGGHTSVVCYLLDY 719
Score = 128 bits (321), Expect = 4e-29
Identities = 113/359 (31%), Positives = 165/359 (45%), Gaps = 45/359 (12%)
Query: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
AC+ GH E+V LL +GA RD +TPL AA G + V +LL +GAD ++
Sbjct: 1090 ACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQS--- 1146
Query: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL 375
E KD L A SG ++++ LL N + TPL L
Sbjct: 1147 -----------------ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Query: 376 AAGYNRVRIVQLLLQHGADVHAK--DKGGLVPLHNACSYGHYEVTELLLKHGACVNA-MD 432
AA V I+++LL GA+++++ K G+ PL A GH +LLL G+ +NA ++
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249
Query: 433 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
+ T L A + R EV SLLL A N ++ + P E Y G
Sbjct: 1250 TNRNTALTLACFQGRTEVVSLLLDRKA-----NVEHRAKTGLTPLMEAASG-GYAEVGRV 1303
Query: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVN 552
LL + + V P S +TAL A H K ELL+ +GA+++
Sbjct: 1304 LLDKGADVNAPPV-------------PSSRDTALTIAADKGHYK---FCELLIGRGAHID 1347
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL 611
+NK TPL +AA H DV+++L + GA ++A D T L A GH++ R L+
Sbjct: 1348 VRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 122 bits (305), Expect = 3e-27
Identities = 101/297 (34%), Positives = 140/297 (47%), Gaps = 23/297 (7%)
Query: 681 EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740
E H T L A +V+ LL GA + +DK G PL A + GH V E+L+ +G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
Query: 741 ASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--TDI 797
A + ++ K TPL A + G+ E+ +LLL GA+ +N TPL L G I
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
Query: 798 QDLLR-------------GDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHL 843
+ LL G + L+ AA G A V+ L +IN + RN T L L
Sbjct: 1200 KILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALTL 1258
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDK 901
A EV LL+ A+V + K GL PL AAS G+ ++ +L+ VNA
Sbjct: 1259 ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1318
Query: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
T L AA KG + C LL+ GA ++N++G TPL LA D+ LL+ A
Sbjct: 1319 SRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQA 1375
Score = 117 bits (294), Expect = 6e-26
Identities = 113/356 (31%), Positives = 166/356 (46%), Gaps = 31/356 (8%)
Query: 125 SNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALR 184
S + + S++PT S ++S S P ++P + + S + + P S
Sbjct: 1031 SGRASAMSNTPTHSIAASISQP-----QTPTPSPIISPSAMLPIYPAIDIDAQTESNHDT 1085
Query: 185 ELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH 243
L AC G V+ L++ A++ +D G +PL AA G VVE LL GA++
Sbjct: 1086 ALTLACAGGHEELVQTLLERGASIEHRDKKG--FTPLILAATAGHVGVVEILLDNGADIE 1143
Query: 244 ARDDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
A+ + PL ACS G EVV LLL +GA+ R+ +YTPL AA G +++ +LL
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1203
Query: 303 QHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNVN 361
GA+ N R T K + L+ AA +G+ + LL ++N
Sbjct: 1204 NAGAEINSR-TGSKLGI-----------------SPLMLAAMNGHTAAVKLLLDMGSDIN 1245
Query: 362 CHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELL 421
R +T L LA R +V LLL A+V + K GL PL A S G+ EV +L
Sbjct: 1246 AQIETNR-NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
Query: 422 LKHGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
L GA VNA + + T L AA K + C LL+ GA + N G + + +A
Sbjct: 1305 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1360
Score = 117 bits (293), Expect = 7e-26
Identities = 107/314 (34%), Positives = 154/314 (49%), Gaps = 25/314 (7%)
Query: 634 AVQQILSESTPIR--TSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHF 690
AV+++L E + T + + L A AG E + L + NV R ++G TPL
Sbjct: 249 AVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG-DITPLMA 307
Query: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
AA V +V+ LL H ADV+A+ G L AC+ G+ +V ++L+ GAS+ +
Sbjct: 308 AANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENG 367
Query: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDA 810
TPL EA + G E+ +LLL++GA NT + KE +AL A
Sbjct: 368 HTPLMEAGSAGHVEVARLLLENGAGI-------NTHSNEFKE------------SALTLA 408
Query: 811 AKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGG 870
KG L V+ L T + T L A ++EVA LL+ GA VN
Sbjct: 409 CYKGHLEMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSF 467
Query: 871 LIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 930
PL AA GHV++AALLI+ + + +TPL EAA++G ++ ALLL GA+
Sbjct: 468 ESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANIN 527
Query: 931 MKNQEGQ-TPLDLA 943
+ +E Q T L LA
Sbjct: 528 AQTEETQETALTLA 541
Score = 115 bits (287), Expect = 4e-25
Identities = 113/357 (31%), Positives = 166/357 (46%), Gaps = 41/357 (11%)
Query: 333 EYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHG 392
E D L A +G E+L+ L + D + TPL LAA V +V++LL +G
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNG 1139
Query: 393 ADVHAK-DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
AD+ A+ ++ PL ACS G EV ELLL GA ++ +TPL AAS V +
Sbjct: 1140 ADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNII 1199
Query: 452 SLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLAL 511
+LL+ GA+ +N S + ++P L+ AA A VK L +
Sbjct: 1200 KILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHTAAVKLLLDM 1240
Query: 512 -EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH 570
IN + + TAL A R +V LLL + ANV + K +TPL AA +
Sbjct: 1241 GSDINAQIETNRNTALTLA---CFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGY 1297
Query: 571 NDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT-- 626
+V VL GA +NA + + TAL AA GH + C LL+ G+ + + +G T
Sbjct: 1298 AEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPL 1357
Query: 627 --AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQLCSSQN 674
AA G+ V Q+L ++ +DVD L+ A + G ++ V+ L N
Sbjct: 1358 WLAANGGHLDVVQLLVQA----GADVDAADNRKITPLMAAFRKGHVKVVRYLVKEVN 1410
Score = 110 bits (276), Expect = 7e-24
Identities = 101/376 (26%), Positives = 166/376 (44%), Gaps = 54/376 (14%)
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
E N D T L +A H ++++ L + GA + D G T L AA AGH+ +LL
Sbjct: 1080 ESNHD--TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLD 1137
Query: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672
G+D E+ RT D L + +G + V +L +
Sbjct: 1138 NGAD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVELLLA 1171
Query: 673 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730
+ N TPL AA V++++ LL+ GA+++++ K G+ PL A GH
Sbjct: 1172 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 1231
Query: 731 EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+LL+ G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 1232 AAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPL-- 1289
Query: 790 VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847
++AA G A V ++ + ++N T L +AA
Sbjct: 1290 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1330
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
+ + E L+ GA ++ ++K G PL AA+ GH+D+ LL++ V+A D TPL
Sbjct: 1331 GHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Query: 908 HEAAQKGRTQLCALLL 923
A +KG ++ L+
Sbjct: 1391 MAAFRKGHVKVVRYLV 1406
Score = 105 bits (262), Expect = 3e-22
Identities = 82/250 (32%), Positives = 125/250 (50%), Gaps = 19/250 (7%)
Query: 537 RKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL--DTLGQTA 594
R++V ELLL +GAN +N TPL +AA + +++++L GA++N+ LG +
Sbjct: 1162 RQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISP 1221
Query: 595 LHRAALAGHLQTCRLLLSYGSDPSI-ISLQGFTAAQM----GNEAVQQILSESTPIRTSD 649
L AA+ GH +LLL GSD + I TA + G V +L + R ++
Sbjct: 1222 LMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLLLD----RKAN 1277
Query: 650 VDYR-------LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVE 701
V++R L+EA+ G E + L +VN + T L AA E
Sbjct: 1278 VEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCE 1337
Query: 702 YLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKG 761
L+ GA + ++K G PL A + GH +V +LLV+ GA V+ AD K TPL A KG
Sbjct: 1338 LLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKG 1397
Query: 762 KYEICKLLLK 771
++ + L+K
Sbjct: 1398 HVKVVRYLVK 1407
Score = 81.3 bits (199), Expect = 6e-15
Identities = 80/257 (31%), Positives = 116/257 (45%), Gaps = 47/257 (18%)
Query: 155 EAAGVSSTAPLGPGAAG-----------PGTGVPAVSGA---LRELLEACRNGDVSRVKR 200
E VS PL A+G G + + +G+ + L+ A NG + VK
Sbjct: 1177 EHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKL 1236
Query: 201 LVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSF 259
L+D +++NA+ R ++ L A GR +VV LL ANV R GL PL A S
Sbjct: 1237 LLDMGSDINAQIETNRNTA-LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASG 1295
Query: 260 GHAEVVSLLLCQGAD------PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 313
G+AEV +LL +GAD P++RD T L AA KG C +L+ GA ++RN
Sbjct: 1296 GYAEVGRVLLDKGADVNAPPVPSSRD----TALTIAADKGHYKFCELLIGRGAHIDVRNK 1351
Query: 314 DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPL 373
G + L L A +G ++ LL + A+D RK TPL
Sbjct: 1352 KGNTPLWL---------------------AANGGHLDVVQLLVQAGADVDAADNRKITPL 1390
Query: 374 HLAAGYNRVRIVQLLLQ 390
A V++V+ L++
Sbjct: 1391 MAAFRKGHVKVVRYLVK 1407
Score = 75.9 bits (185), Expect = 2e-13
Identities = 85/327 (25%), Positives = 134/327 (40%), Gaps = 40/327 (12%)
Query: 640 SESTPIRTSDVDYR-----LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGY 694
++ +RT D + + LLEA+ G L T + R L S L AA
Sbjct: 159 ADGADLRTVDPETQARLEALLEAAGIGKLSTADGKAFADPEVLRRLTSSVSCALDEAAA- 217
Query: 695 NRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPL 754
++ A+ D L ACS G L+ G SVN + L
Sbjct: 218 ---ALTRMRAESTANAGQSDNRSLA---EACSEGDVNAVRKLLIEGRSVNEHTEEGESLL 271
Query: 755 HEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKG 814
A + G YE+ ++LL A+ + ++GD L AA G
Sbjct: 272 CLACSAGYYELAQVLLAMHANVEDRG--------------------IKGDITPLMAAANG 311
Query: 815 CLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLI 872
++ KL ++N + + G + A GY ++V + LLE GA + ++ G
Sbjct: 312 GHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGY--VDVVKVLLESGASIEDHNENGHT 369
Query: 873 PLHNAASYGHVDIAALLIKYNTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM 931
PL A S GHV++A LL++ +N ++++ + L A KG ++ LL GAD
Sbjct: 370 PLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEH 429
Query: 932 KNQEGQTPLDLATAD---DIRALLIDA 955
K E T L A D ++ LL+D+
Sbjct: 430 KTDEMHTALMEACMDGHVEVARLLLDS 456
Score = 68.6 bits (166), Expect = 4e-11
Identities = 41/114 (35%), Positives = 61/114 (53%), Gaps = 1/114 (0%)
Query: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
T+ + T L LA + E+ + LLE GA + +DK G PL AA+ GHV + +L+
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 893 NTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
+ A +++ TPL A GR ++ LLLA GA+ +N TPL LA +
Sbjct: 1139 GADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192
Score = 64.7 bits (156), Expect = 6e-10
Identities = 119/493 (24%), Positives = 180/493 (36%), Gaps = 82/493 (16%)
Query: 171 GPGTGVPAVSGALRE--LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGR 228
G G + A + +E L AC G + L+ A D+ S+PL AA G
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAG----ADIELGCSTPLMEAAQEGH 576
Query: 229 KDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHE 288
++V++LL GANVHA G L AC GH +V +LL GAD TPL +
Sbjct: 577 LELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMK 636
Query: 289 AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 348
AA G + L+ GA+ N R T + N+
Sbjct: 637 AARAGHVCTVQFLISKGANVN-RTT-------------------------------ANND 664
Query: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
+++ LA + +V+LLL HGAD + K G L
Sbjct: 665 HTVLS---------------------LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 703
Query: 409 ACSYGHYEVTELLLKHG---ACVNAMDLWQFT-PLHEAASKNRVEVCSL-LLSHGADPTL 463
A GH V LL + D+ Q T P H+ RV V +L ++ +P
Sbjct: 704 AAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP-- 761
Query: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
K ++A T +R + + K S L A + + I+ ++ Q
Sbjct: 762 ----DKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIV--EEAQGKL 815
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
T L + K Q+ L L A+ ++ K+ + L+ E ++L +
Sbjct: 816 TELEQRIKEAIEKNAQLQSLEL---AHADQLTKEKIEELNKTREEQIQKKQKILEELQKV 872
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
L Q L + L ++ R+ L S L T +G + LSE
Sbjct: 873 ERELQLKTQQQLKKQYL--EVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQ-----LSEGD 925
Query: 644 PIRTSDVDYRLLE 656
R VD LL+
Sbjct: 926 YARLQQVDPVLLK 938
Score = 38.5 bits (88), Expect = 0.043
Identities = 42/165 (25%), Positives = 61/165 (36%), Gaps = 27/165 (16%)
Query: 14 HQQQLQPAPGASAPPPPP------PPP----LSPGLAPGTTPASPTASGLAPFASPRHGL 63
H Q QP S P PP PPP P LA + P + ++ + P+ +
Sbjct: 2105 HSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPVTYPMPQTPM 2164
Query: 64 ALPEGDGSRDPPD-RPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAG 122
P+ + P RP P GT+ S +V SS A ++ N
Sbjct: 2165 GCPQPTPKMETPAIRP----PPHGTTAPHKNSA-----------SVQNSSVAVLSVNHI- 2208
Query: 123 SGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGP 167
++ PSS P++ S+ S A P A S+ P GP
Sbjct: 2209 KRPHSVPSSVQLPSTLSTQSACQNSVHPANKPIAPNFSAPLPFGP 2253
Score = 37.7 bits (86), Expect = 0.074
Identities = 27/91 (29%), Positives = 39/91 (42%)
Query: 74 PPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSS 133
P P SP P S S + +A+P A S+ AG P + + SSSS
Sbjct: 2039 PVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSS 2098
Query: 134 SPTSSSSSSPSSPGSSLAESPEAAGVSSTAP 164
S +SS+ S+ P S+++ P S P
Sbjct: 2099 SGSSSAHSNQQQPPGSVSQEPRPPLQQSQVP 2129
Score = 32.0 bits (71), Expect = 4.1
Identities = 33/149 (22%), Positives = 52/149 (34%)
Query: 18 LQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDR 77
L PA ++P P P S + G+ S + +P + + G + P
Sbjct: 1932 LSPARATNSPKPHMVPRHSNQNSSGSQVNSAGSLTSSPTTTTSSSASTVPGTSTNGSPSS 1991
Query: 78 PRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTS 137
P + T ++ +T TV + ++A P +SPSS S P
Sbjct: 1992 PSVRRQLFVTVVKTSNATTTTVTTTASNNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ 2051
Query: 138 SSSSSPSSPGSSLAESPEAAGVSSTAPLG 166
S +SP + SP SS G
Sbjct: 2052 PGGVSRNSPLDCGSASPNKVASSSEQEAG 2080
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 167 bits (423), Expect = 6e-41
Identities = 162/527 (30%), Positives = 232/527 (44%), Gaps = 59/527 (11%)
Query: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
L EA G ++ LL G N +G+S L LA + G Y+ ++L A +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 262
Query: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
E++ G K TPL A+ + IV+LLL H ADV+++ G
Sbjct: 263 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
Query: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
L AC+ G ++ ++LL GA + + TPL EAAS VEV +LL HGA
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 363
Query: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
+N H EFK +L A + L V+ L +
Sbjct: 364 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
TAL A H +V LLL GA VN F +PL +AA H ++ +L + GA
Sbjct: 407 TALMEACMDGH---VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ----GFTAAQMG--NEAVQQ 637
+ ++ G T L AA GH + LLL+ G++ + + + T A G +E
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQ-LCSSQNVNCRDLEGRHSTPLHFAAGYNR 696
++ I L+EAS+ G LE VK L S NV+ G T L +A
Sbjct: 524 LIKAGADIELG-CSTPLMEASQEGHLELVKYLLASGANVHATTATG--DTALTYACENGH 580
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK-FTPLH 755
V + LL GAD+ + +GG PL A GH + L+ GA+VN A T +
Sbjct: 581 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVS 640
Query: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLL 801
A A G + +LLL HGADPT + +DG+T L + K G T++ L
Sbjct: 641 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 166 bits (419), Expect = 2e-40
Identities = 176/565 (31%), Positives = 249/565 (44%), Gaps = 82/565 (14%)
Query: 184 RELLEACRNGDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L EAC +GDV+ V++L+D +VN G S L A G ++ + LL M ANV
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGE--SLLCLACSAGYYELAQVLLAMHANV 264
Query: 243 HARDD-GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
R + G + PL A S G+ ++V LLL AD N++ T L A G +D+ VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNV 360
L GA+ N +G + L +EAA +G+ E LL +
Sbjct: 325 LNEGANIEDHNENGHTPL--------------------MEAASAGHVEVARVLLDHGAGI 364
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LL GA VN +PL AA VE+ +LL+ GA+ VN G TP
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY-------TP-- 474
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
L++AARE V LA IN + ++ ETAL A +
Sbjct: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
V + L++ GA++ TPL A++ H ++++ L GA ++A G TAL A
Sbjct: 520 VADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659
GH +LL G+D + ES RT L++A++
Sbjct: 577 ENGHTDVADVLLQAGAD---------------------LEHESEGGRTP-----LMKAAR 610
Query: 660 AGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
AG L TV+ L S NVN H T + A ++VVE LL HGAD + K G
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669
Query: 719 VPLHNACSYGHYEVAELLVRHGASV 743
L A GH V L+ + +V
Sbjct: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694
Score = 150 bits (378), Expect = 1e-35
Identities = 173/616 (28%), Positives = 253/616 (41%), Gaps = 98/616 (15%)
Query: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
LL+ + DGK+ ADP LT + +E AL
Sbjct: 149 LLEAAGIGKLSTADGKA---FADPEVLRRLTS---------SVSCALDEAAAALTRMKAE 196
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H + + L A V V+ LL G V+ + G L ACS G+YE+ ++
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Query: 421 LLK-HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479
LL H + + TPL A+S +++ LLL H AD + G +A
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA-------- 308
Query: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQ 539
LTY G + D+ KV
Sbjct: 309 ----LTYACAGGFV-------DIVKV---------------------------------- 323
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNA-LDTLGQTALHRA 598
LL +GAN+ + N++ TPL AA H +V VL HGA +N + ++AL A
Sbjct: 324 ----LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM----GNEAVQQILSES---TPIRTSDVD 651
GHL R LL G+D + + TA G+ V ++L +S + +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 652 YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
L A+ G +E + L + N ++ TPL AA +V LL GA+++
Sbjct: 440 SPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 712 AK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
A+ ++ L AC G EVA+ L++ GA + +L TPL EA+ +G E+ K LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLL 555
Query: 771 KHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR------------GDAALLDAAKKGCLA 817
GA+ G+T L E G TD+ D+L G L+ AA+ G L
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
Query: 818 RVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876
VQ L + N+N R T + T + LA +L V E LL HGAD + K G L
Sbjct: 616 TVQFLISKGANVN-RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
Query: 877 AASYGHVDIAALLIKY 892
AA GH ++ + L+ Y
Sbjct: 675 AAKGGHTNVVSYLLDY 690
Score = 141 bits (356), Expect = 4e-33
Identities = 142/470 (30%), Positives = 215/470 (45%), Gaps = 26/470 (5%)
Query: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
SL +A + D+ V+K L + + E+ L A ++ + + QV LL ANV
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 264
Query: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
++ NK +TPL A+ + D++++L H A +N+ G TAL A G + ++L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 611 LSYGSDPSIISLQGFT----AAQMGN-EAVQQILSESTPIRTSDVDYR---LLEASKAGD 662
L+ G++ + G T AA G+ E + +L I T +++ L A G
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
L+ V+ L + + H T L A V V LL GA V+ PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
A GH E+A LL+ GA++ + +TPL EAA +G E+ LLL GA+ + +
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 783 GN-TPLDLVKEGD-TDIQDLLRGDAA---------LLDAAKKGCLARVQKLCTPENINCR 831
T L L G +++ D L A L++A+++G L V+ L N
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVH 562
Query: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
T T L A + +VA+ LL+ GAD+ + +GG PL AA GH+ LI
Sbjct: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
Query: 892 YNTCVN-ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
VN AT T + A G + LLLAHGADPT + ++G T L
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 672
Score = 135 bits (340), Expect = 3e-31
Identities = 138/447 (30%), Positives = 197/447 (44%), Gaps = 64/447 (14%)
Query: 181 GALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
G + L+ A G + VK L+ A+VN++ G ++ L +A G D+V+ LL G
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEG 328
Query: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKIDVC 298
AN+ ++ G PL A S GH EV +LL GA N N + + L A KG +D+
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 299 IVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDE----LLEAARSGNEEKLMAL 354
LL+ GAD E+K DE L+EA G+ E L
Sbjct: 389 RFLLEAGADQ------------------------EHKTDEMHTALMEACMDGHVEVARLL 424
Query: 355 L-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYG 413
L + VN A +PL LAA V + LL++ GA++ + G PL A G
Sbjct: 425 LDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREG 482
Query: 414 HYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
H E+ LLL GA +NA + Q T L A EV L+ GAD L C
Sbjct: 483 HEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL-GC------ 535
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
TP L++A++E L VK LA + +TAL A +
Sbjct: 536 ---STP--------------LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN-ALDTLG 591
H V ++LL+ GA++ +++ TPL AA H ++ L GA +N A
Sbjct: 579 GH---TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 635
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPS 618
T + A GHL LLL++G+DP+
Sbjct: 636 HTVVSLACAGGHLAVVELLLAHGADPT 662
Score = 124 bits (311), Expect = 6e-28
Identities = 114/386 (29%), Positives = 173/386 (44%), Gaps = 46/386 (11%)
Query: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
AC+ GH E+VS+L+ + A RD +TPL AA G + V +LL G D ++
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS--- 1118
Query: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL 375
E KD L A SG ++++ LL N + TPL L
Sbjct: 1119 -----------------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Query: 376 AAGYNRVRIVQLLLQHGADVHAK--DKGGLVPLHNACSYGHYEVTELLLKHGACVNA-MD 432
AA V I+++LL GA+++++ K G+ PL A GH +LLL G+ +NA ++
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
Query: 433 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
+ T L A + R EV SLLL A N ++ + P E Y G
Sbjct: 1222 TNRNTALTLACFQGRAEVVSLLLDRKA-----NVEHRAKTGLTPLMEAASG-GYAEVGRV 1275
Query: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVN 552
LL + + V P S +TAL A H K ELL+ +GA+++
Sbjct: 1276 LLDKGADVNAPPV-------------PSSRDTALTIAADKGHYK---FCELLIHRGAHID 1319
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL- 611
+NK TPL +A+ H DV+++L + GA ++A D T L A GH++ + L+
Sbjct: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Query: 612 SYGSDPSIISLQGFTAAQMGNEAVQQ 637
PS I + A E +++
Sbjct: 1380 EVNQFPSDIECMRYIATITDKELLKK 1405
Score = 115 bits (288), Expect = 3e-25
Identities = 104/311 (33%), Positives = 150/311 (48%), Gaps = 19/311 (6%)
Query: 650 VDYR-LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHG 707
VD R L EA GD+ V++L ++VN EG L +AGY ++ V +H
Sbjct: 204 VDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 263
Query: 708 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K
Sbjct: 264 VEDRG-NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 768 LLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRG-------------DAALLDAAKK 813
+LL GA+ N +G+TPL + G ++ +L ++AL A K
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 814 GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIP 873
G L V+ L T + T L A ++EVA LL+ GA VN P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 874 LHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKN 933
L AA GHV++AALLI+ + + +TPL EAA++G ++ ALLLA GA+ +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 934 QEGQ-TPLDLA 943
+E Q T L LA
Sbjct: 502 EETQETALTLA 512
Score = 113 bits (283), Expect = 1e-24
Identities = 108/378 (28%), Positives = 165/378 (43%), Gaps = 75/378 (19%)
Query: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHG 468
AC+ GH E+ +L+ A + D FTPL AA+ V V +LL
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD------------ 1109
Query: 469 KSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC 528
KG + EA + K T +L C
Sbjct: 1110 --------------------KGGDI-----EAQSERTKDT--------------PLSLAC 1130
Query: 529 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL- 587
+ R++V +LLL +GAN +N TPL +AA + +++++L GA++N+
Sbjct: 1131 SGG-----RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
Query: 588 -DTLGQTALHRAALAGHLQTCRLLLSYGSDPSI-ISLQGFTAAQM----GNEAVQQILSE 641
LG + L AA+ GH+ +LLL GSD + I TA + G V +L +
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
Query: 642 STPIRTSDVDYR-------LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAG 693
R ++V++R L+EA+ G E + L +VN + T L AA
Sbjct: 1246 ----RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
Query: 694 YNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753
E L+H GA + ++K G PL A + GH++V +LLV+ GA V+ AD K TP
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
Query: 754 LHEAAAKGKYEICKLLLK 771
L A KG ++ + L+K
Sbjct: 1362 LMSAFRKGHVKVVQYLVK 1379
Score = 113 bits (283), Expect = 1e-24
Identities = 105/372 (28%), Positives = 165/372 (44%), Gaps = 23/372 (6%)
Query: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
L+ A G V V+ L+D K +PL A GR++VV+ LL GAN R
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLLQ 303
+ PL A S G+ ++ +LL GA+ N+R +PL AA+ G + +LL
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
Query: 304 HGADPNIR-NTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEE 349
G+D N + T+ +AL LA D A + L+EAA G E
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
Query: 350 KLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
LL +VN + T L +AA + +LL+ GA + ++K G PL
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
Query: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNCH 467
A + GH++V +LL++ GA V+A D + TPL A K V+V L+ P+ + C
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIEC- 1390
Query: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
+ T +E L + + A++ A+ K ++ + +S E +
Sbjct: 1391 ----MRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRK 1446
Query: 528 CAVASLHPKRKQ 539
A+A+ KRK+
Sbjct: 1447 QALAAKREKRKE 1458
Score = 112 bits (280), Expect = 2e-24
Identities = 113/373 (30%), Positives = 171/373 (45%), Gaps = 41/373 (10%)
Query: 324 PSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVR 383
PS E D L A +G E+L+++L + D + TPL LAA V
Sbjct: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
Query: 384 IVQLLLQHGADVHAK-DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
+V++LL G D+ A+ ++ PL ACS G EV +LLL GA ++ +TPL A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
AS V + +LL+ GA+ +N S + ++P L+ AA +
Sbjct: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
Query: 503 AKVKKTLAL-EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561
VK L + IN + + TAL A R +V LLL + ANV + K +TP
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLA---CFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 562 LHVAAERAHNDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
L AA + +V VL GA +NA + + TAL AA GH + C LL+ G+ +
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 620 ISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQ 668
+ +G T A+ G+ V Q+L ++ +DVD L+ A + G ++ V+
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQA----GADVDAADNRKITPLMSAFRKGHVKVVQY 1376
Query: 669 LCSSQNVNCRDLE 681
L N D+E
Sbjct: 1377 LVKEVNQFPSDIE 1389
Score = 112 bits (280), Expect = 2e-24
Identities = 97/297 (32%), Positives = 136/297 (45%), Gaps = 23/297 (7%)
Query: 681 EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740
E H T L A +V L+ A + +DK G PL A + GH V E+L+ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 741 ASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--TDI 797
+ ++ K TPL A + G+ E+ LLL GA+ +N TPL L G I
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 798 QDLLR-------------GDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHL 843
+ LL G + L+ AA G + V+ L +IN + RN T L L
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTL 1230
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDK 901
A EV LL+ A+V + K GL PL AAS G+ ++ +L+ VNA
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
T L AA KG + C LL+ GA ++N++G TPL LA+ D+ LL+ A
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347
Score = 109 bits (272), Expect = 2e-23
Identities = 113/354 (31%), Positives = 162/354 (45%), Gaps = 34/354 (9%)
Query: 131 SSSSPTSSSSSSPSSPGSSLAESPEAAG--VSSTAPLGPGAAGPGTGVPAVSGALRE--L 186
S+ PT S+SSS ++ +PE+ S+ A P + A + + + L
Sbjct: 1004 STRVPTGSNSSSQTTE----CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
Query: 187 LEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
AC G V L+ A + +D G +PL AA G VVE LL G ++ A+
Sbjct: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 246 DDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
+ PL ACS G EVV LLL +GA+ R+ +YTPL AA G +++ +LL
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNVNCH 363
GA+ N R T K + L+ AA +G+ + LL ++N
Sbjct: 1178 GAEINSR-TGSKLGI-----------------SPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
R +T L LA R +V LLL A+V + K GL PL A S G+ EV +LL
Sbjct: 1220 IETNR-NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
Query: 424 HGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
GA VNA + + T L AA K + C LL+ GA + N G + + +A
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Score = 108 bits (270), Expect = 3e-23
Identities = 101/376 (26%), Positives = 162/376 (43%), Gaps = 54/376 (14%)
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
E N D T L +A H +++ VL AK+ D G T L AA AGH+ +LL
Sbjct: 1052 ESNHD--TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672
G D E+ RT D L + +G + V L +
Sbjct: 1110 KGGD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVDLLLA 1143
Query: 673 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730
+ N TPL AA V++++ LL+ GA+++++ K G+ PL A GH
Sbjct: 1144 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHV 1203
Query: 731 EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+LL+ G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-- 1261
Query: 790 VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847
++AA G A V ++ + ++N T L +AA
Sbjct: 1262 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
+ + E L+ GA ++ ++K G PL A++ GH D+ LL++ V+A D TPL
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 908 HEAAQKGRTQLCALLL 923
A +KG ++ L+
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378
Score = 105 bits (263), Expect = 2e-22
Identities = 97/320 (30%), Positives = 147/320 (45%), Gaps = 23/320 (7%)
Query: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
L+ AS G L+ VK L +VN + G +T L +A V +V+ LL+ GA++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLK 771
++ G PL A S GH EVA +L+ HGA +N ++ +K + L A KG ++ + LL+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 772 HGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRGDAAL-----------LDAAKKGCLARV 819
GAD K + +T L + +G ++ LL A L A G +
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-DKGGLIPLHNAA 878
L N + TPL AA + E+ LL GA++NAQ ++ L A
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 879 SYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQT 938
G ++A LIK + + TPL EA+Q+G +L LLA GA+ G T
Sbjct: 514 CGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 939 PLDLATAD---DIRALLIDA 955
L A + D+ +L+ A
Sbjct: 571 ALTYACENGHTDVADVLLQA 590
Score = 94.7 bits (234), Expect = 5e-19
Identities = 100/313 (31%), Positives = 131/313 (41%), Gaps = 23/313 (7%)
Query: 648 SDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706
S+ D L A G E V L + + RD +G TPL AA V VVE LL
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
Query: 707 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
G D+ A+ ++ PL ACS G EV +LL+ GA+ ++ +TPL AA+ G I
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 766 CKLLLKHGADPTKKN-------------RDGNTP---LDLVKEGDTDIQDLLRGDAALLD 809
K+LL GA+ + +G+ P L L D + Q + AL
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A +G A V L N TPL AA EV LL+ GADVNA
Sbjct: 1231 ACFQG-RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
Query: 870 GL--IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
L AA GH LLI ++ +K TPL A+ G + LL+ GA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 928 DPTMKNQEGQTPL 940
D + TPL
Sbjct: 1350 DVDAADNRKITPL 1362
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 1/122 (0%)
Query: 183 LRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
L L+EA G + L+D A+VNA + + + L AA G E L+ GA+
Sbjct: 1258 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH 1317
Query: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
+ R+ G PL A + GH +VV LL+ GAD +A DN TPL A KG + V L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Query: 302 LQ 303
++
Sbjct: 1378 VK 1379
Score = 60.8 bits (146), Expect = 8e-09
Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 1/114 (0%)
Query: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
T+ + T L LA + E+ L+ A + +DK G PL AA+ GHV + +L+
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
Query: 893 NTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
+ A +++ TPL A GR ++ LLLA GA+ +N TPL LA +
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Score = 42.4 bits (98), Expect = 0.003
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902
A ++ LL+ G VN + G L A S G+ ++A +L+ + V + +K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952
TPL A+ G + LLL H AD ++ G T L A A D ++ LL
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Score = 32.7 bits (73), Expect = 2.4
Identities = 36/144 (25%), Positives = 56/144 (38%), Gaps = 25/144 (17%)
Query: 25 SAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPV 84
S+ P P++ G AP T + T+ A+P D+P +
Sbjct: 1984 SSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMA---- 2039
Query: 85 DGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPS 144
+CT P+ + +S + A N G+ + PSSS +PTSS++ +
Sbjct: 2040 ----------NLCT-------PSSTANSCSSSASNTPGAPETH-PSSSPTPTSSNTQEEA 2081
Query: 145 SPGSSLAESPEA---AGVSSTAPL 165
P S SP + A S APL
Sbjct: 2082 QPSSVSDLSPMSMPFASNSEPAPL 2105
Score = 32.3 bits (72), Expect = 3.1
Identities = 35/164 (21%), Positives = 59/164 (35%), Gaps = 26/164 (15%)
Query: 59 PRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAP 118
P+ LPE + + + P++ S +TT+TI A + V A V
Sbjct: 1479 PKENSELPEDEDEEENDEDVEQEVPIEPPS-ATTTTTIGISATSATFTNVFGKKRANVVT 1537
Query: 119 NPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPA 178
P+ + N + +P ++ P SLA+ + P G GA G
Sbjct: 1538 TPSTNRKNKKNKTKETPPTAHLILPEQ-HMSLAQQKADKNKINGEPRGGGAGG------- 1589
Query: 179 VSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHF 222
N D +D+ + N++ +G KS L+F
Sbjct: 1590 -------------NSDSDN----LDSTDCNSESSSGGKSQELNF 1616
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 167 bits (423), Expect = 6e-41
Identities = 162/527 (30%), Positives = 232/527 (44%), Gaps = 59/527 (11%)
Query: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
L EA G ++ LL G N +G+S L LA + G Y+ ++L A +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 262
Query: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
E++ G K TPL A+ + IV+LLL H ADV+++ G
Sbjct: 263 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
Query: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
L AC+ G ++ ++LL GA + + TPL EAAS VEV +LL HGA
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 363
Query: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
+N H EFK +L A + L V+ L +
Sbjct: 364 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
TAL A H +V LLL GA VN F +PL +AA H ++ +L + GA
Sbjct: 407 TALMEACMDGH---VEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQ----GFTAAQMG--NEAVQQ 637
+ ++ G T L AA GH + LLL+ G++ + + + T A G +E
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADF 523
Query: 638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQ-LCSSQNVNCRDLEGRHSTPLHFAAGYNR 696
++ I L+EAS+ G LE VK L S NV+ G T L +A
Sbjct: 524 LIKAGADIELG-CSTPLMEASQEGHLELVKYLLASGANVHATTATG--DTALTYACENGH 580
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK-FTPLH 755
V + LL GAD+ + +GG PL A GH + L+ GA+VN A T +
Sbjct: 581 TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVS 640
Query: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLL 801
A A G + +LLL HGADPT + +DG+T L + K G T++ L
Sbjct: 641 LACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687
Score = 166 bits (419), Expect = 2e-40
Identities = 176/565 (31%), Positives = 249/565 (44%), Gaps = 82/565 (14%)
Query: 184 RELLEACRNGDVSRVKRLVDAA-NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L EAC +GDV+ V++L+D +VN G S L A G ++ + LL M ANV
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGE--SLLCLACSAGYYELAQVLLAMHANV 264
Query: 243 HARDD-GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
R + G + PL A S G+ ++V LLL AD N++ T L A G +D+ VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP-LNV 360
L GA+ N +G + L +EAA +G+ E LL +
Sbjct: 325 LNEGANIEDHNENGHTPL--------------------MEAASAGHVEVARVLLDHGAGI 364
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LL GA VN +PL AA VE+ +LL+ GA+ VN G TP
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGY-------TP-- 474
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
L++AARE V LA IN + ++ ETAL A +
Sbjct: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGF---SE 519
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
V + L++ GA++ TPL A++ H ++++ L GA ++A G TAL A
Sbjct: 520 VADFLIKAGADIE---LGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659
GH +LL G+D + ES RT L++A++
Sbjct: 577 ENGHTDVADVLLQAGAD---------------------LEHESEGGRTP-----LMKAAR 610
Query: 660 AGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
AG L TV+ L S NVN H T + A ++VVE LL HGAD + K G
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDH-TVVSLACAGGHLAVVELLLAHGADPTHRLKDGS 669
Query: 719 VPLHNACSYGHYEVAELLVRHGASV 743
L A GH V L+ + +V
Sbjct: 670 TMLIEAAKGGHTNVVSYLLDYPNNV 694
Score = 150 bits (378), Expect = 1e-35
Identities = 173/616 (28%), Positives = 253/616 (41%), Gaps = 98/616 (15%)
Query: 301 LLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNV 360
LL+ + DGK+ ADP LT + +E AL
Sbjct: 149 LLEAAGIGKLSTADGKA---FADPEVLRRLTS---------SVSCALDEAAAALTRMKAE 196
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H + + L A V V+ LL G V+ + G L ACS G+YE+ ++
Sbjct: 197 NSHNAGQVDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV 256
Query: 421 LLK-HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479
LL H + + TPL A+S +++ LLL H AD + G +A
Sbjct: 257 LLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA-------- 308
Query: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQ 539
LTY G + D+ KV
Sbjct: 309 ----LTYACAGGFV-------DIVKV---------------------------------- 323
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNA-LDTLGQTALHRA 598
LL +GAN+ + N++ TPL AA H +V VL HGA +N + ++AL A
Sbjct: 324 ----LLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLA 379
Query: 599 ALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM----GNEAVQQILSES---TPIRTSDVD 651
GHL R LL G+D + + TA G+ V ++L +S + +
Sbjct: 380 CYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 652 YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
L A+ G +E + L + N ++ TPL AA +V LL GA+++
Sbjct: 440 SPLTLAACGGHVE-LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANIN 498
Query: 712 AK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLL 770
A+ ++ L AC G EVA+ L++ GA + +L TPL EA+ +G E+ K LL
Sbjct: 499 AQTEETQETALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLL 555
Query: 771 KHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR------------GDAALLDAAKKGCLA 817
GA+ G+T L E G TD+ D+L G L+ AA+ G L
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
Query: 818 RVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHN 876
VQ L + N+N R T + T + LA +L V E LL HGAD + K G L
Sbjct: 616 TVQFLISKGANVN-RATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIE 674
Query: 877 AASYGHVDIAALLIKY 892
AA GH ++ + L+ Y
Sbjct: 675 AAKGGHTNVVSYLLDY 690
Score = 141 bits (356), Expect = 4e-33
Identities = 142/470 (30%), Positives = 215/470 (45%), Gaps = 26/470 (5%)
Query: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
SL +A + D+ V+K L + + E+ L A ++ + + QV LL ANV
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 264
Query: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
++ NK +TPL A+ + D++++L H A +N+ G TAL A G + ++L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 611 LSYGSDPSIISLQGFT----AAQMGN-EAVQQILSESTPIRTSDVDYR---LLEASKAGD 662
L+ G++ + G T AA G+ E + +L I T +++ L A G
Sbjct: 325 LNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGH 384
Query: 663 LETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLH 722
L+ V+ L + + H T L A V V LL GA V+ PL
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 723 NACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRD 782
A GH E+A LL+ GA++ + +TPL EAA +G E+ LLL GA+ + +
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEE 503
Query: 783 GN-TPLDLVKEGD-TDIQDLLRGDAA---------LLDAAKKGCLARVQKLCTPENINCR 831
T L L G +++ D L A L++A+++G L V+ L N
Sbjct: 504 TQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLA-SGANVH 562
Query: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
T T L A + +VA+ LL+ GAD+ + +GG PL AA GH+ LI
Sbjct: 563 ATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
Query: 892 YNTCVN-ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
VN AT T + A G + LLLAHGADPT + ++G T L
Sbjct: 623 KGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 672
Score = 135 bits (340), Expect = 3e-31
Identities = 138/447 (30%), Positives = 197/447 (44%), Gaps = 64/447 (14%)
Query: 181 GALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
G + L+ A G + VK L+ A+VN++ G ++ L +A G D+V+ LL G
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEG 328
Query: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKIDVC 298
AN+ ++ G PL A S GH EV +LL GA N N + + L A KG +D+
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 299 IVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDE----LLEAARSGNEEKLMAL 354
LL+ GAD E+K DE L+EA G+ E L
Sbjct: 389 RFLLEAGADQ------------------------EHKTDEMHTALMEACMDGHVEVARLL 424
Query: 355 L-TPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYG 413
L + VN A +PL LAA V + LL++ GA++ + G PL A G
Sbjct: 425 LDSGAQVNMPADS--FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREG 482
Query: 414 HYEVTELLLKHGACVNAM-DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
H E+ LLL GA +NA + Q T L A EV L+ GAD L C
Sbjct: 483 HEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL-GC------ 535
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVAS 532
TP L++A++E L VK LA + +TAL A +
Sbjct: 536 ---STP--------------LMEASQEGHLELVKYLLASGANVHATTATGDTALTYACEN 578
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN-ALDTLG 591
H V ++LL+ GA++ +++ TPL AA H ++ L GA +N A
Sbjct: 579 GH---TDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANND 635
Query: 592 QTALHRAALAGHLQTCRLLLSYGSDPS 618
T + A GHL LLL++G+DP+
Sbjct: 636 HTVVSLACAGGHLAVVELLLAHGADPT 662
Score = 124 bits (311), Expect = 6e-28
Identities = 114/386 (29%), Positives = 173/386 (44%), Gaps = 46/386 (11%)
Query: 256 ACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDG 315
AC+ GH E+VS+L+ + A RD +TPL AA G + V +LL G D ++
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQS--- 1118
Query: 316 KSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL 375
E KD L A SG ++++ LL N + TPL L
Sbjct: 1119 -----------------ERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSL 1161
Query: 376 AAGYNRVRIVQLLLQHGADVHAK--DKGGLVPLHNACSYGHYEVTELLLKHGACVNA-MD 432
AA V I+++LL GA+++++ K G+ PL A GH +LLL G+ +NA ++
Sbjct: 1162 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIE 1221
Query: 433 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
+ T L A + R EV SLLL A N ++ + P E Y G
Sbjct: 1222 TNRNTALTLACFQGRAEVVSLLLDRKA-----NVEHRAKTGLTPLMEAASG-GYAEVGRV 1275
Query: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVN 552
LL + + V P S +TAL A H K ELL+ +GA+++
Sbjct: 1276 LLDKGADVNAPPV-------------PSSRDTALTIAADKGHYK---FCELLIHRGAHID 1319
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLL- 611
+NK TPL +A+ H DV+++L + GA ++A D T L A GH++ + L+
Sbjct: 1320 VRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Query: 612 SYGSDPSIISLQGFTAAQMGNEAVQQ 637
PS I + A E +++
Sbjct: 1380 EVNQFPSDIECMRYIATITDKELLKK 1405
Score = 115 bits (288), Expect = 3e-25
Identities = 104/311 (33%), Positives = 150/311 (48%), Gaps = 19/311 (6%)
Query: 650 VDYR-LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHG 707
VD R L EA GD+ V++L ++VN EG L +AGY ++ V +H
Sbjct: 204 VDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 263
Query: 708 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K
Sbjct: 264 VEDRG-NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 768 LLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRG-------------DAALLDAAKK 813
+LL GA+ N +G+TPL + G ++ +L ++AL A K
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 814 GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIP 873
G L V+ L T + T L A ++EVA LL+ GA VN P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 874 LHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKN 933
L AA GHV++AALLI+ + + +TPL EAA++G ++ ALLLA GA+ +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 934 QEGQ-TPLDLA 943
+E Q T L LA
Sbjct: 502 EETQETALTLA 512
Score = 113 bits (283), Expect = 1e-24
Identities = 108/378 (28%), Positives = 165/378 (43%), Gaps = 75/378 (19%)
Query: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHG 468
AC+ GH E+ +L+ A + D FTPL AA+ V V +LL
Sbjct: 1062 ACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD------------ 1109
Query: 469 KSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHC 528
KG + EA + K T +L C
Sbjct: 1110 --------------------KGGDI-----EAQSERTKDT--------------PLSLAC 1130
Query: 529 AVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL- 587
+ R++V +LLL +GAN +N TPL +AA + +++++L GA++N+
Sbjct: 1131 SGG-----RQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1185
Query: 588 -DTLGQTALHRAALAGHLQTCRLLLSYGSDPSI-ISLQGFTAAQM----GNEAVQQILSE 641
LG + L AA+ GH+ +LLL GSD + I TA + G V +L +
Sbjct: 1186 GSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLD 1245
Query: 642 STPIRTSDVDYR-------LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAG 693
R ++V++R L+EA+ G E + L +VN + T L AA
Sbjct: 1246 ----RKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAAD 1301
Query: 694 YNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753
E L+H GA + ++K G PL A + GH++V +LLV+ GA V+ AD K TP
Sbjct: 1302 KGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITP 1361
Query: 754 LHEAAAKGKYEICKLLLK 771
L A KG ++ + L+K
Sbjct: 1362 LMSAFRKGHVKVVQYLVK 1379
Score = 113 bits (283), Expect = 1e-24
Identities = 105/372 (28%), Positives = 165/372 (44%), Gaps = 23/372 (6%)
Query: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
L+ A G V V+ L+D K +PL A GR++VV+ LL GAN R
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNAR--DNWNYTPLHEAAIKGKIDVCIVLLQ 303
+ PL A S G+ ++ +LL GA+ N+R +PL AA+ G + +LL
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
Query: 304 HGADPNIR-NTDGKSALDLA-------------DPSAKAVLTGEYKKDELLEAARSGNEE 349
G+D N + T+ +AL LA D A + L+EAA G E
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
Query: 350 KLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
LL +VN + T L +AA + +LL+ GA + ++K G PL
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
Query: 409 ACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH-GADPTLVNCH 467
A + GH++V +LL++ GA V+A D + TPL A K V+V L+ P+ + C
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEVNQFPSDIEC- 1390
Query: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
+ T +E L + + A++ A+ K ++ + +S E +
Sbjct: 1391 ----MRYIATITDKELLKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRK 1446
Query: 528 CAVASLHPKRKQ 539
A+A+ KRK+
Sbjct: 1447 QALAAKREKRKE 1458
Score = 112 bits (280), Expect = 2e-24
Identities = 113/373 (30%), Positives = 171/373 (45%), Gaps = 41/373 (10%)
Query: 324 PSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVR 383
PS E D L A +G E+L+++L + D + TPL LAA V
Sbjct: 1043 PSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVG 1102
Query: 384 IVQLLLQHGADVHAK-DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
+V++LL G D+ A+ ++ PL ACS G EV +LLL GA ++ +TPL A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162
Query: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
AS V + +LL+ GA+ +N S + ++P L+ AA +
Sbjct: 1163 ASGGYVNIIKILLNAGAE---INSRTGSKLGISP----------------LMLAAMNGHV 1203
Query: 503 AKVKKTLAL-EIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561
VK L + IN + + TAL A R +V LLL + ANV + K +TP
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLA---CFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 562 LHVAAERAHNDVMEVLHKHGAKMNA--LDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
L AA + +V VL GA +NA + + TAL AA GH + C LL+ G+ +
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 620 ISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYR-------LLEASKAGDLETVKQ 668
+ +G T A+ G+ V Q+L ++ +DVD L+ A + G ++ V+
Sbjct: 1321 RNKKGNTPLWLASNGGHFDVVQLLVQA----GADVDAADNRKITPLMSAFRKGHVKVVQY 1376
Query: 669 LCSSQNVNCRDLE 681
L N D+E
Sbjct: 1377 LVKEVNQFPSDIE 1389
Score = 112 bits (280), Expect = 2e-24
Identities = 97/297 (32%), Positives = 136/297 (45%), Gaps = 23/297 (7%)
Query: 681 EGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHG 740
E H T L A +V L+ A + +DK G PL A + GH V E+L+ G
Sbjct: 1052 ESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKG 1111
Query: 741 ASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGD--TDI 797
+ ++ K TPL A + G+ E+ LLL GA+ +N TPL L G I
Sbjct: 1112 GDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNII 1171
Query: 798 QDLLR-------------GDAALLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHL 843
+ LL G + L+ AA G + V+ L +IN + RN T L L
Sbjct: 1172 KILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRN-TALTL 1230
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNA--TDK 901
A EV LL+ A+V + K GL PL AAS G+ ++ +L+ VNA
Sbjct: 1231 ACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPS 1290
Query: 902 WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
T L AA KG + C LL+ GA ++N++G TPL LA+ D+ LL+ A
Sbjct: 1291 SRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQA 1347
Score = 109 bits (272), Expect = 2e-23
Identities = 113/354 (31%), Positives = 162/354 (45%), Gaps = 34/354 (9%)
Query: 131 SSSSPTSSSSSSPSSPGSSLAESPEAAG--VSSTAPLGPGAAGPGTGVPAVSGALRE--L 186
S+ PT S+SSS ++ +PE+ S+ A P + A + + + L
Sbjct: 1004 STRVPTGSNSSSQTTE----CLTPESCSQTTSNVASQSMPPVYPSVDIDAHTESNHDTAL 1059
Query: 187 LEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
AC G V L+ A + +D G +PL AA G VVE LL G ++ A+
Sbjct: 1060 TLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 246 DDGGL-IPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
+ PL ACS G EVV LLL +GA+ R+ +YTPL AA G +++ +LL
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL-TPLNVNCH 363
GA+ N R T K + L+ AA +G+ + LL ++N
Sbjct: 1178 GAEINSR-TGSKLGI-----------------SPLMLAAMNGHVPAVKLLLDMGSDINAQ 1219
Query: 364 ASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLK 423
R +T L LA R +V LLL A+V + K GL PL A S G+ EV +LL
Sbjct: 1220 IETNR-NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLD 1278
Query: 424 HGACVNA--MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
GA VNA + + T L AA K + C LL+ GA + N G + + +A
Sbjct: 1279 KGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLA 1332
Score = 108 bits (270), Expect = 3e-23
Identities = 101/376 (26%), Positives = 162/376 (43%), Gaps = 54/376 (14%)
Query: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
E N D T L +A H +++ VL AK+ D G T L AA AGH+ +LL
Sbjct: 1052 ESNHD--TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLD 1109
Query: 613 YGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSS 672
G D E+ RT D L + +G + V L +
Sbjct: 1110 KGGD-----------------------IEAQSERTKDTP---LSLACSGGRQEVVDLLLA 1143
Query: 673 QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAK--DKGGLVPLHNACSYGHY 730
+ N TPL AA V++++ LL+ GA+++++ K G+ PL A GH
Sbjct: 1144 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHV 1203
Query: 731 EVAELLVRHGASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789
+LL+ G+ +N + + T L A +G+ E+ LLL A+ + + G TPL
Sbjct: 1204 PAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPL-- 1261
Query: 790 VKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQGRNSTPLHLAAGY 847
++AA G A V ++ + ++N T L +AA
Sbjct: 1262 ------------------MEAASGG-YAEVGRVLLDKGADVNAPPVPSSRDTALTIAADK 1302
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
+ + E L+ GA ++ ++K G PL A++ GH D+ LL++ V+A D TPL
Sbjct: 1303 GHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPL 1362
Query: 908 HEAAQKGRTQLCALLL 923
A +KG ++ L+
Sbjct: 1363 MSAFRKGHVKVVQYLV 1378
Score = 105 bits (263), Expect = 2e-22
Identities = 97/320 (30%), Positives = 147/320 (45%), Gaps = 23/320 (7%)
Query: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
L+ AS G L+ VK L +VN + G +T L +A V +V+ LL+ GA++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLK 771
++ G PL A S GH EVA +L+ HGA +N ++ +K + L A KG ++ + LL+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 772 HGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRGDAAL-----------LDAAKKGCLARV 819
GAD K + +T L + +G ++ LL A L A G +
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-DKGGLIPLHNAA 878
L N + TPL AA + E+ LL GA++NAQ ++ L A
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 879 SYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQT 938
G ++A LIK + + TPL EA+Q+G +L LLA GA+ G T
Sbjct: 514 CGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 939 PLDLATAD---DIRALLIDA 955
L A + D+ +L+ A
Sbjct: 571 ALTYACENGHTDVADVLLQA 590
Score = 94.7 bits (234), Expect = 5e-19
Identities = 100/313 (31%), Positives = 131/313 (41%), Gaps = 23/313 (7%)
Query: 648 SDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706
S+ D L A G E V L + + RD +G TPL AA V VVE LL
Sbjct: 1053 SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FTPLILAATAGHVGVVEILLDK 1110
Query: 707 GADVHAK-DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
G D+ A+ ++ PL ACS G EV +LL+ GA+ ++ +TPL AA+ G I
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNI 1170
Query: 766 CKLLLKHGADPTKKN-------------RDGNTP---LDLVKEGDTDIQDLLRGDAALLD 809
K+LL GA+ + +G+ P L L D + Q + AL
Sbjct: 1171 IKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTL 1230
Query: 810 AAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKG 869
A +G A V L N TPL AA EV LL+ GADVNA
Sbjct: 1231 ACFQG-RAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP 1289
Query: 870 GL--IPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
L AA GH LLI ++ +K TPL A+ G + LL+ GA
Sbjct: 1290 SSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGA 1349
Query: 928 DPTMKNQEGQTPL 940
D + TPL
Sbjct: 1350 DVDAADNRKITPL 1362
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/122 (36%), Positives = 62/122 (50%), Gaps = 1/122 (0%)
Query: 183 LRELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN 241
L L+EA G + L+D A+VNA + + + L AA G E L+ GA+
Sbjct: 1258 LTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAH 1317
Query: 242 VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
+ R+ G PL A + GH +VV LL+ GAD +A DN TPL A KG + V L
Sbjct: 1318 IDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYL 1377
Query: 302 LQ 303
++
Sbjct: 1378 VK 1379
Score = 60.8 bits (146), Expect = 8e-09
Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 1/114 (0%)
Query: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892
T+ + T L LA + E+ L+ A + +DK G PL AA+ GHV + +L+
Sbjct: 1051 TESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDK 1110
Query: 893 NTCVNA-TDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
+ A +++ TPL A GR ++ LLLA GA+ +N TPL LA +
Sbjct: 1111 GGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164
Score = 42.4 bits (98), Expect = 0.003
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902
A ++ LL+ G VN + G L A S G+ ++A +L+ + V + +K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952
TPL A+ G + LLL H AD ++ G T L A A D ++ LL
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
Score = 32.7 bits (73), Expect = 2.4
Identities = 36/144 (25%), Positives = 56/144 (38%), Gaps = 25/144 (17%)
Query: 25 SAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPV 84
S+ P P++ G AP T + T+ A+P D+P +
Sbjct: 1984 SSLPSVSSAPITSGQAPTTFLPASTSQAQLSSQKMESFSAVPPTKEKVSTQDQPMA---- 2039
Query: 85 DGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPS 144
+CT P+ + +S + A N G+ + PSSS +PTSS++ +
Sbjct: 2040 ----------NLCT-------PSSTANSCSSSASNTPGAPETH-PSSSPTPTSSNTQEEA 2081
Query: 145 SPGSSLAESPEA---AGVSSTAPL 165
P S SP + A S APL
Sbjct: 2082 QPSSVSDLSPMSMPFASNSEPAPL 2105
Score = 32.3 bits (72), Expect = 3.1
Identities = 35/164 (21%), Positives = 59/164 (35%), Gaps = 26/164 (15%)
Query: 59 PRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAP 118
P+ LPE + + + P++ S +TT+TI A + V A V
Sbjct: 1479 PKENSELPEDEDEEENDEDVEQEVPIEPPS-ATTTTTIGISATSATFTNVFGKKRANVVT 1537
Query: 119 NPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTAPLGPGAAGPGTGVPA 178
P+ + N + +P ++ P SLA+ + P G GA G
Sbjct: 1538 TPSTNRKNKKNKTKETPPTAHLILPEQ-HMSLAQQKADKNKINGEPRGGGAGG------- 1589
Query: 179 VSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHF 222
N D +D+ + N++ +G KS L+F
Sbjct: 1590 -------------NSDSDN----LDSTDCNSESSSGGKSQELNF 1616
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 161 bits (407), Expect = 4e-39
Identities = 132/420 (31%), Positives = 186/420 (44%), Gaps = 51/420 (12%)
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
T LH VA ++ LLL +V+ + TPL +AA+ D+ +L HGA
Sbjct: 364 TPLHFLVAQGSVEQ---VRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
N +D G LH AA G T RLLL +G+ +G+T
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTP---------------- 464
Query: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703
L + + E V +L S+ + E TPLH AA + VS+V+ L
Sbjct: 465 -----------LHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513
Query: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
GA++ A+ + PLH A G + L++ GA + D + PLH AAA+GKY
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 764 EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLC 823
ICK+LL++GA G TPL L AA KG L + L
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHL--------------------AAYKGHL-EIIHLL 612
Query: 824 TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHV 883
+ N N TPLHLAA + V LL+ GAD NA ++ G PLH A
Sbjct: 613 AESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTF 672
Query: 884 DIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
L++++ V+A +K +TP H AA KG T + +L+ GA +++ TPL LA
Sbjct: 673 LSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 150 bits (380), Expect = 6e-36
Identities = 144/481 (29%), Positives = 206/481 (42%), Gaps = 69/481 (14%)
Query: 316 KSALDLAD-----PSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNVNCHASDGRK 369
K AL L+D P + + E K L G+ E++ LL ++V+C + G
Sbjct: 338 KRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGY- 396
Query: 370 STPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN 429
TPL +AA + + LLL HGAD + D+ G PLH A G LLL HGACV+
Sbjct: 397 -TPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVD 455
Query: 430 AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFK 489
A + +TPLH AA N V LL+S ADP L GK+ + +A +
Sbjct: 456 AQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVA-----------AYF 504
Query: 490 GHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGA 549
GH L K+ + E+ Q ++ T LH AV + + + LL+ GA
Sbjct: 505 GH--------VSLVKLLTSQGAEL--DAQQRNLRTPLHLAV---ERGKVRAIQHLLKSGA 551
Query: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
+ ++ PLH AA R + ++L ++GA + G T LH AA GHL+ L
Sbjct: 552 VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHL 611
Query: 610 LLSYGSDPSIISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLET 665
L ++ + +T AA+ G EAV L
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSAL-------------------------- 645
Query: 666 VKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNAC 725
L + N + G TPLH A + V LL H A+VHA++K G P H A
Sbjct: 646 ---LQCGADPNAAEQSG--WTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAA 700
Query: 726 SYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNT 785
G+ + ++LV GA ++V D TPL A K I L G +P+ G+
Sbjct: 701 LKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL--EGKEPSVATLGGSK 758
Query: 786 P 786
P
Sbjct: 759 P 759
Score = 146 bits (368), Expect = 1e-34
Identities = 131/459 (28%), Positives = 201/459 (43%), Gaps = 46/459 (10%)
Query: 184 RELLEACRNGDVSRVKRLVDAANVNAKD----MAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
+EL+++ + R +L D N+ +D + K +PLHF G + V LL
Sbjct: 326 QELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHE 385
Query: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCI 299
+V + G PL A ++ +LLL GAD N D + PLH AA G
Sbjct: 386 VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTAR 445
Query: 300 VLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLN 359
+LL HGA + + +G + L L A N E + LL
Sbjct: 446 LLLDHGACVDAQEREGWTPLHL---------------------AAQNNFENVARLLVSRQ 484
Query: 360 VNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTE 419
+ + + TPLH+AA + V +V+LL GA++ A+ + PLH A G +
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQ 544
Query: 420 LLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479
LLK GA +A+D + PLH AA++ + +C +LL +GA L G + + +A
Sbjct: 545 HLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKG 604
Query: 480 LRERLTYEFKGHS------------LLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
E + + H+ L AAR + A V L QS T LH
Sbjct: 605 HLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLH 664
Query: 528 CAVASLHPKRKQVTEL--LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
AV +R + LL ANV+ +NK TP H+AA + + +++VL + GA+++
Sbjct: 665 LAV-----QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLD 719
Query: 586 ALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG 624
D + T L + AL Q L G +PS+ +L G
Sbjct: 720 VQDGVSCTPL-QLALRSRKQGIMSFLE-GKEPSVATLGG 756
Score = 120 bits (300), Expect = 1e-26
Identities = 110/397 (27%), Positives = 162/397 (40%), Gaps = 54/397 (13%)
Query: 559 MTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPS 618
+TPLH + + + +L H ++ G T L AA C LLL++G+D +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 619 IISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCR 678
+ G+ A++ GD T + L + C
Sbjct: 423 RVDEDGWAPLHF--------------------------AAQNGDDGTARLLLD--HGACV 454
Query: 679 DLEGRHS-TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLV 737
D + R TPLH AA N +V L+ AD + + G PLH A +GH + +LL
Sbjct: 455 DAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLT 514
Query: 738 RHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDI 797
GA ++ TPLH A +GK + LLK GA P ++ G PL +
Sbjct: 515 SQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
Query: 798 --QDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEY 855
+ LLR A+L +G TPLHLAA +LE+
Sbjct: 575 ICKMLLRYGASLELPTHQGW-----------------------TPLHLAAYKGHLEIIHL 611
Query: 856 LLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915
L E A++ A PLH AA +G + + L++ NA ++ +TPLH A Q+
Sbjct: 612 LAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRST 671
Query: 916 TQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
LL H A+ +N+ G TP LA A+L
Sbjct: 672 FLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/192 (32%), Positives = 87/192 (45%), Gaps = 19/192 (9%)
Query: 756 EAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGC 815
E+ A + CKL L+ P + N D + L D+D + L+ L D +K
Sbjct: 300 ESKALARKVSCKLSLRQ---PGEVNEDISQELM-----DSDSGNYLKRALQLSD--RKNL 349
Query: 816 LARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLH 875
+ R ++LC EN TPLH ++E LL H DV+ Q G PL
Sbjct: 350 VPRDEELCIYEN---------KVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLL 400
Query: 876 NAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQE 935
AA D+ ALL+ + N D+ + PLH AAQ G LLL HGA + +E
Sbjct: 401 IAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE 460
Query: 936 GQTPLDLATADD 947
G TPL LA ++
Sbjct: 461 GWTPLHLAAQNN 472
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 144 bits (364), Expect = 4e-34
Identities = 166/568 (29%), Positives = 238/568 (41%), Gaps = 54/568 (9%)
Query: 325 SAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI 384
S + G ++ AA +G++ L L+ + D TPL +R+
Sbjct: 4 SENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDC 63
Query: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444
LL+ GADV+ D LH A G+Y +LLL A DL + TPLH +
Sbjct: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTT 122
Query: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 504
++R C LL P V+ K+ L Y H L L K
Sbjct: 123 RHRSPKCLALLLKFMAPGEVDTQDKNK-----QTALHWSAYYNNPEHVKL-------LIK 170
Query: 505 VKKTLALEIINFKQPQSHETALHCAVASLHPKR----KQVTELLLRKGANVNEKNKDFMT 560
+ + + K P H A H +++H R TE LL N ++ + T
Sbjct: 171 HDSNIGIPDVEGKIPL-HWAANHKDPSAVHTVRCILDAAPTESLL------NWQDYEGRT 223
Query: 561 PLHVAAERAHNDVMEVLHKH-GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
PLH A + V++VL + + + D L +T LH AAL GH Q LLL +I
Sbjct: 224 PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283
Query: 620 IS-LQGFT----AAQMG-NEAVQQILSESTPIRTSDVDYR---LLEASKAGD--LETVKQ 668
S QG T AAQ E V+ L + SD++ R + A K D L T+
Sbjct: 284 PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343
Query: 669 LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYG 728
L S ++N D G T LH AA VS V+ LL + A V A D PL AC G
Sbjct: 344 LKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401
Query: 729 HYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD 788
H +V + L++ GA V++ D + LH AA G ++C++L+++ +P ++ G TPL
Sbjct: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461
Query: 789 LVKEG--------------DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI-NCRDT 833
G D +IQD G AL + G L ++ L N +
Sbjct: 462 CAAYGGYINCMAVLMENNADPNIQD-KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN 520
Query: 834 QGRNSTPLHLAAGYNNLEVAEYLLEHGA 861
TPL A EV +++LEHGA
Sbjct: 521 NEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 130 bits (326), Expect = 1e-29
Identities = 127/439 (28%), Positives = 195/439 (44%), Gaps = 63/439 (14%)
Query: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576
K S TALH A + +LLL + AN +K+ + MTPLH+ + +
Sbjct: 76 KTDHSQRTALHLAAQK---GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 577 LHKHGA--KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG-----FTAAQ 629
L K A +++ D QTALH +A + + +LL+ + S+ I ++G + A
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 630 MGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLH 689
AV + +L+A+ L +N +D EGR TPLH
Sbjct: 193 KDPSAVHTVRC-------------ILDAAPTESL-----------LNWQDYEGR--TPLH 226
Query: 690 FAAGYNRVSVVEYLL-HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-AD 747
FA V+VV+ L + ++ + D PLH A GH ++ LL+ S + +D
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
Query: 748 LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAAL 807
TPLH AA E K+ LKH P+ K+ D+D++ G +
Sbjct: 287 SQGATPLHYAAQSNFAETVKVFLKH---PSVKD-------------DSDLE----GRTSF 326
Query: 808 LDAAKKGC---LARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864
+ AA KG L + L + +IN D G T LH AA ++ + LLE+ A V+
Sbjct: 327 MWAAGKGSDDVLRTMLSLKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVD 384
Query: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924
A D PL A GH D+ LIK V+ D+ + LH AA G +C +L+
Sbjct: 385 ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444
Query: 925 HGADPTMKNQEGQTPLDLA 943
+ +P +++ G+TPL A
Sbjct: 445 NKINPNVQDYAGRTPLQCA 463
Score = 124 bits (312), Expect = 5e-28
Identities = 145/563 (25%), Positives = 238/563 (42%), Gaps = 56/563 (9%)
Query: 178 AVSGALRELLEACRNGDVSRVKRLV--DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHL 235
A S ++ A NGD ++RL+ ++A + +D GR +PL + R D + L
Sbjct: 10 AGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGR--TPLMYCVLADRLDCADAL 67
Query: 236 LQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295
L+ GA+V+ D LH A G+ + LLL + A+ +D TPLH + +
Sbjct: 68 LKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTTRHRS 126
Query: 296 DVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL 355
C+ LL P +T K+ K L + N + + LL
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKN------------------KQTALHWSAYYNNPEHVKLL 168
Query: 356 TPLNVNCHASDGRKSTPLHLAAGY---NRVRIVQLLLQHGAD---VHAKDKGGLVPLHNA 409
+ N D PLH AA + + V V+ +L ++ +D G PLH A
Sbjct: 169 IKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFA 228
Query: 410 CSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN--- 465
+ G+ V ++L + +C + + D TPLH AA ++ LLL T+ +
Sbjct: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288
Query: 466 ----CHGKSAVDMAPT-------PELRERLTYEFKGHSLLQAAREA-DLAKVKKTLALEI 513
H + + A T P +++ E + + A + + D+ + +L +I
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
+ TALH A S H +LLL A V+ + TPL A E H DV
Sbjct: 349 DINMADKYGGTALHAAALSGH---VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 574 MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQ 629
++ L K GA+++ +D G + LH AAL G+ C++L+ +P++ G T AA
Sbjct: 406 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 465
Query: 630 MGNEAVQQILSESTP---IRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHS 685
G +L E+ I+ + L + G L+ +K L + N +
Sbjct: 466 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERY 525
Query: 686 TPLHFAAGYNRVSVVEYLLHHGA 708
TPL +A R V++++L HGA
Sbjct: 526 TPLDYALLGERHEVIQFMLEHGA 548
Score = 107 bits (268), Expect = 6e-23
Identities = 118/422 (27%), Positives = 189/422 (44%), Gaps = 63/422 (14%)
Query: 175 GVPAVSGALRELLEACRNGD---VSRVKRLVDAAN----VNAKDMAGRKSSPLHFAAGFG 227
G+P V G + L A + D V V+ ++DAA +N +D GR +PLHFA G
Sbjct: 176 GIPDVEGKI-PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR--TPLHFAVADG 232
Query: 228 RKDVVEHLLQM-GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ---GADPNARDNWNY 283
VV+ L N+ + D+ PLH A GHA++V LLL + G P+ D+
Sbjct: 233 NVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DSQGA 290
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAA 343
TPLH AA + V L+H + + + +G+++ + AA
Sbjct: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSF--------------------MWAA 330
Query: 344 RSGNEEKLMALLT-PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
G+++ L +L+ +++ + +D T LH AA V V+LLL++ A V A D
Sbjct: 331 GKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMK 390
Query: 403 LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPT 462
PL AC GH +V + L+K GA V+ +D + LH AA +VC +L+ + +P
Sbjct: 391 HTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN 450
Query: 463 LVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSH 522
+ + G++ + A + G+ A + A Q +
Sbjct: 451 VQDYAGRTPLQCA-----------AYGGYINCMAVLMENNADPN----------IQDKEG 489
Query: 523 ETALHCAVASLHPKRKQVTELLLRKGA--NVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580
TALH S + +LLL A N E N++ TPL A ++V++ + +H
Sbjct: 490 RTALHW---SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEH 546
Query: 581 GA 582
GA
Sbjct: 547 GA 548
Score = 75.1 bits (183), Expect = 4e-13
Identities = 73/240 (30%), Positives = 101/240 (42%), Gaps = 58/240 (24%)
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
+D+ G PL + A+ L++ GA VN D + T LH AA KG Y KLLL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
Query: 773 GADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRD 832
A+ +K+ + TPL L + CLA + K P + D
Sbjct: 104 RANWMQKDLEEMTPLHLTTRHRSP-----------------KCLALLLKFMAPGEV---D 143
Query: 833 TQGRNS-TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
TQ +N T LH +A YNN E + L++H +++ D G IPLH AA+ H D +A+
Sbjct: 144 TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDPSAV--- 198
Query: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT-----MKNQEGQTPLDLATAD 946
T C L A PT ++ EG+TPL A AD
Sbjct: 199 -----------------------HTVRCIL----DAAPTESLLNWQDYEGRTPLHFAVAD 231
Score = 50.8 bits (120), Expect = 8e-06
Identities = 39/110 (35%), Positives = 51/110 (46%), Gaps = 3/110 (2%)
Query: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
+D+ G PL +D A L+K VN TD T LH AAQKG + LLL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
Query: 926 GADPTMKNQEGQTPLDLAT---ADDIRALLIDAMPPEALPTCFKPQATVV 972
A+ K+ E TPL L T + ALL+ M P + T K + T +
Sbjct: 104 RANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTAL 153
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 144 bits (364), Expect = 4e-34
Identities = 166/568 (29%), Positives = 238/568 (41%), Gaps = 54/568 (9%)
Query: 325 SAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRI 384
S + G ++ AA +G++ L L+ + D TPL +R+
Sbjct: 4 SENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDC 63
Query: 385 VQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAAS 444
LL+ GADV+ D LH A G+Y +LLL A DL + TPLH +
Sbjct: 64 ADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTT 122
Query: 445 KNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAK 504
++R C LL P V+ K+ L Y H L L K
Sbjct: 123 RHRSPKCLALLLKFMAPGEVDTQDKNK-----QTALHWSAYYNNPEHVKL-------LIK 170
Query: 505 VKKTLALEIINFKQPQSHETALHCAVASLHPKR----KQVTELLLRKGANVNEKNKDFMT 560
+ + + K P H A H +++H R TE LL N ++ + T
Sbjct: 171 HDSNIGIPDVEGKIPL-HWAANHKDPSAVHTVRCILDAAPTESLL------NWQDYEGRT 223
Query: 561 PLHVAAERAHNDVMEVLHKH-GAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
PLH A + V++VL + + + D L +T LH AAL GH Q LLL +I
Sbjct: 224 PLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTI 283
Query: 620 IS-LQGFT----AAQMG-NEAVQQILSESTPIRTSDVDYR---LLEASKAGD--LETVKQ 668
S QG T AAQ E V+ L + SD++ R + A K D L T+
Sbjct: 284 PSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLS 343
Query: 669 LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYG 728
L S ++N D G T LH AA VS V+ LL + A V A D PL AC G
Sbjct: 344 LKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMG 401
Query: 729 HYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD 788
H +V + L++ GA V++ D + LH AA G ++C++L+++ +P ++ G TPL
Sbjct: 402 HKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQ 461
Query: 789 LVKEG--------------DTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENI-NCRDT 833
G D +IQD G AL + G L ++ L N +
Sbjct: 462 CAAYGGYINCMAVLMENNADPNIQD-KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMEN 520
Query: 834 QGRNSTPLHLAAGYNNLEVAEYLLEHGA 861
TPL A EV +++LEHGA
Sbjct: 521 NEERYTPLDYALLGERHEVIQFMLEHGA 548
Score = 130 bits (326), Expect = 1e-29
Identities = 127/439 (28%), Positives = 195/439 (44%), Gaps = 63/439 (14%)
Query: 517 KQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV 576
K S TALH A + +LLL + AN +K+ + MTPLH+ + +
Sbjct: 76 KTDHSQRTALHLAAQK---GNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLAL 132
Query: 577 LHKHGA--KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQG-----FTAAQ 629
L K A +++ D QTALH +A + + +LL+ + S+ I ++G + A
Sbjct: 133 LLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANH 192
Query: 630 MGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLH 689
AV + +L+A+ L +N +D EGR TPLH
Sbjct: 193 KDPSAVHTVRC-------------ILDAAPTESL-----------LNWQDYEGR--TPLH 226
Query: 690 FAAGYNRVSVVEYLL-HHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-AD 747
FA V+VV+ L + ++ + D PLH A GH ++ LL+ S + +D
Sbjct: 227 FAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSD 286
Query: 748 LWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAAL 807
TPLH AA E K+ LKH P+ K+ D+D++ G +
Sbjct: 287 SQGATPLHYAAQSNFAETVKVFLKH---PSVKD-------------DSDLE----GRTSF 326
Query: 808 LDAAKKGC---LARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864
+ AA KG L + L + +IN D G T LH AA ++ + LLE+ A V+
Sbjct: 327 MWAAGKGSDDVLRTMLSLKSDIDINMADKYG--GTALHAAALSGHVSTVKLLLENNAQVD 384
Query: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA 924
A D PL A GH D+ LIK V+ D+ + LH AA G +C +L+
Sbjct: 385 ATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIE 444
Query: 925 HGADPTMKNQEGQTPLDLA 943
+ +P +++ G+TPL A
Sbjct: 445 NKINPNVQDYAGRTPLQCA 463
Score = 124 bits (312), Expect = 5e-28
Identities = 145/563 (25%), Positives = 238/563 (42%), Gaps = 56/563 (9%)
Query: 178 AVSGALRELLEACRNGDVSRVKRLV--DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHL 235
A S ++ A NGD ++RL+ ++A + +D GR +PL + R D + L
Sbjct: 10 AGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGR--TPLMYCVLADRLDCADAL 67
Query: 236 LQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKI 295
L+ GA+V+ D LH A G+ + LLL + A+ +D TPLH + +
Sbjct: 68 LKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLH-LTTRHRS 126
Query: 296 DVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALL 355
C+ LL P +T K+ K L + N + + LL
Sbjct: 127 PKCLALLLKFMAPGEVDTQDKN------------------KQTALHWSAYYNNPEHVKLL 168
Query: 356 TPLNVNCHASDGRKSTPLHLAAGY---NRVRIVQLLLQHGAD---VHAKDKGGLVPLHNA 409
+ N D PLH AA + + V V+ +L ++ +D G PLH A
Sbjct: 169 IKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFA 228
Query: 410 CSYGHYEVTELLLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVN--- 465
+ G+ V ++L + +C + + D TPLH AA ++ LLL T+ +
Sbjct: 229 VADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQ 288
Query: 466 ----CHGKSAVDMAPT-------PELRERLTYEFKGHSLLQAAREA-DLAKVKKTLALEI 513
H + + A T P +++ E + + A + + D+ + +L +I
Sbjct: 289 GATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDI 348
Query: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
+ TALH A S H +LLL A V+ + TPL A E H DV
Sbjct: 349 DINMADKYGGTALHAAALSGH---VSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 574 MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQ 629
++ L K GA+++ +D G + LH AAL G+ C++L+ +P++ G T AA
Sbjct: 406 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 465
Query: 630 MGNEAVQQILSESTP---IRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHS 685
G +L E+ I+ + L + G L+ +K L + N +
Sbjct: 466 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERY 525
Query: 686 TPLHFAAGYNRVSVVEYLLHHGA 708
TPL +A R V++++L HGA
Sbjct: 526 TPLDYALLGERHEVIQFMLEHGA 548
Score = 107 bits (268), Expect = 6e-23
Identities = 118/422 (27%), Positives = 189/422 (44%), Gaps = 63/422 (14%)
Query: 175 GVPAVSGALRELLEACRNGD---VSRVKRLVDAAN----VNAKDMAGRKSSPLHFAAGFG 227
G+P V G + L A + D V V+ ++DAA +N +D GR +PLHFA G
Sbjct: 176 GIPDVEGKI-PLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGR--TPLHFAVADG 232
Query: 228 RKDVVEHLLQM-GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ---GADPNARDNWNY 283
VV+ L N+ + D+ PLH A GHA++V LLL + G P+ D+
Sbjct: 233 NVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPS--DSQGA 290
Query: 284 TPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAA 343
TPLH AA + V L+H + + + +G+++ + AA
Sbjct: 291 TPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSF--------------------MWAA 330
Query: 344 RSGNEEKLMALLT-PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402
G+++ L +L+ +++ + +D T LH AA V V+LLL++ A V A D
Sbjct: 331 GKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMK 390
Query: 403 LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPT 462
PL AC GH +V + L+K GA V+ +D + LH AA +VC +L+ + +P
Sbjct: 391 HTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPN 450
Query: 463 LVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSH 522
+ + G++ + A + G+ A + A Q +
Sbjct: 451 VQDYAGRTPLQCA-----------AYGGYINCMAVLMENNADPN----------IQDKEG 489
Query: 523 ETALHCAVASLHPKRKQVTELLLRKGA--NVNEKNKDFMTPLHVAAERAHNDVMEVLHKH 580
TALH S + +LLL A N E N++ TPL A ++V++ + +H
Sbjct: 490 RTALHW---SCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFMLEH 546
Query: 581 GA 582
GA
Sbjct: 547 GA 548
Score = 75.1 bits (183), Expect = 4e-13
Identities = 73/240 (30%), Positives = 101/240 (42%), Gaps = 58/240 (24%)
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
+D+ G PL + A+ L++ GA VN D + T LH AA KG Y KLLL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
Query: 773 GADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRD 832
A+ +K+ + TPL L + CLA + K P + D
Sbjct: 104 RANWMQKDLEEMTPLHLTTRHRSP-----------------KCLALLLKFMAPGEV---D 143
Query: 833 TQGRNS-TPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
TQ +N T LH +A YNN E + L++H +++ D G IPLH AA+ H D +A+
Sbjct: 144 TQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAAN--HKDPSAV--- 198
Query: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT-----MKNQEGQTPLDLATAD 946
T C L A PT ++ EG+TPL A AD
Sbjct: 199 -----------------------HTVRCIL----DAAPTESLLNWQDYEGRTPLHFAVAD 231
Score = 50.8 bits (120), Expect = 8e-06
Identities = 39/110 (35%), Positives = 51/110 (46%), Gaps = 3/110 (2%)
Query: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAH 925
+D+ G PL +D A L+K VN TD T LH AAQKG + LLL
Sbjct: 44 EDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTR 103
Query: 926 GADPTMKNQEGQTPLDLAT---ADDIRALLIDAMPPEALPTCFKPQATVV 972
A+ K+ E TPL L T + ALL+ M P + T K + T +
Sbjct: 104 RANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTAL 153
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 143 bits (361), Expect = 1e-33
Identities = 139/437 (31%), Positives = 199/437 (45%), Gaps = 54/437 (12%)
Query: 184 RELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L EAC +GDV+ V++L+D +VN G S L A G ++ + LL M ANV
Sbjct: 207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 264
Query: 243 HAR-DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
R + G + PL A S G+ ++V LLL AD N++ T L A G +D+ VL
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNV 360
L GA+ N +G + L+EAA +G+ E LL +
Sbjct: 325 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 364
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 365 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 423
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LL GA VN +PL AA VE+ +LL+ GA+ VN D TP
Sbjct: 424 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 474
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
L++AARE V LA IN + ++ ETAL A +
Sbjct: 475 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG---GFSE 519
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
V + L++ GA++ TPL A++ H ++++ L GA ++A G TAL A
Sbjct: 520 VADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 576
Query: 600 LAGHLQTCRLLLSYGSD 616
GH +LL G+D
Sbjct: 577 ENGHTDVADVLLQAGAD 593
Score = 132 bits (331), Expect = 3e-30
Identities = 139/494 (28%), Positives = 205/494 (41%), Gaps = 84/494 (17%)
Query: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
L EA G ++ LL G N +G+S L LA + G Y+ ++L A +
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 262
Query: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
E++ G K TPL A+ + IV+LLL H ADV+++ G
Sbjct: 263 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 306
Query: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
L AC+ G ++ ++LL GA + + TPL EAAS VEV +LL HGA
Sbjct: 307 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 363
Query: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
+N H EFK +L A + L V+ L +
Sbjct: 364 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 406
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
TAL A H +V LLL GA VN F +PL +AA H ++ +L + GA
Sbjct: 407 TALMEACMDGHV---EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
+ ++ G T L AA GH + LLL+ G++ +
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA------------------------ 499
Query: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703
+T + L + G V D+E STPL A+ + +V+YL
Sbjct: 500 --QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYL 554
Query: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
L GA+VHA G L AC GH +VA++L++ GA ++ + K + E K+
Sbjct: 555 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK--TILEGIDPAKH 612
Query: 764 EI------CKLLLK 771
++ CKLL K
Sbjct: 613 QVRVAFDACKLLRK 626
Score = 131 bits (329), Expect = 5e-30
Identities = 129/441 (29%), Positives = 199/441 (45%), Gaps = 59/441 (13%)
Query: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
SL +A + D+ V+K L + + E+ L A ++ + + QV LL ANV
Sbjct: 208 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 264
Query: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
++ NK +TPL A+ + D++++L H A +N+ G TAL A G + ++L
Sbjct: 265 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 324
Query: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670
L+ G++ + G T L+EA+ AG +E + L
Sbjct: 325 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 358
Query: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+N E + S L A + +V +LL GAD K L AC GH
Sbjct: 359 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 417
Query: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL
Sbjct: 418 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 476
Query: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847
+ +EG ++ LL A NIN + T+ T L LA
Sbjct: 477 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 515
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
EVA++L++ GAD+ + G PL A+ GH+++ L+ V+AT T L
Sbjct: 516 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 572
Query: 908 HEAAQKGRTQLCALLLAHGAD 928
A + G T + +LL GAD
Sbjct: 573 TYACENGHTDVADVLLQAGAD 593
Score = 115 bits (288), Expect = 3e-25
Identities = 104/311 (33%), Positives = 150/311 (48%), Gaps = 19/311 (6%)
Query: 650 VDYR-LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHG 707
VD R L EA GD+ V++L ++VN EG L +AGY ++ V +H
Sbjct: 204 VDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 263
Query: 708 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K
Sbjct: 264 VEDRG-NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 768 LLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRG-------------DAALLDAAKK 813
+LL GA+ N +G+TPL + G ++ +L ++AL A K
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 814 GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIP 873
G L V+ L T + T L A ++EVA LL+ GA VN P
Sbjct: 383 GHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 441
Query: 874 LHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKN 933
L AA GHV++AALLI+ + + +TPL EAA++G ++ ALLLA GA+ +
Sbjct: 442 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 501
Query: 934 QEGQ-TPLDLA 943
+E Q T L LA
Sbjct: 502 EETQETALTLA 512
Score = 110 bits (276), Expect = 7e-24
Identities = 127/488 (26%), Positives = 200/488 (40%), Gaps = 71/488 (14%)
Query: 306 ADPNIRNTDGKSALDLADPSAKAVL---------TGEYKKDELLEAARSGNEEKLMALLT 356
ADP + S D +A A+ G+ L EA G+ + LL
Sbjct: 167 ADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLD 226
Query: 357 P-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK-DKGGLVPLHNACSYGH 414
+VN H +G L +AGY + Q+LL A+V + +KG + PL A S G+
Sbjct: 227 EGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGNKGDITPLMAASSGGY 284
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 474
++ +LLL H A VN+ T L A + V++ +LL+ GA+ + H ++
Sbjct: 285 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN---IEDHNEN---- 337
Query: 475 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI--INFKQPQSHETALHCAVAS 532
GH+ L A A +V + L IN + E+AL A
Sbjct: 338 ---------------GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 382
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H + LL GA+ K + T L A H +V +L GA++N +
Sbjct: 383 GH---LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 439
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
+ L AA GH++ LL+ G++ ++ +G+T
Sbjct: 440 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTP------------------------- 474
Query: 653 RLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
L+EA++ G E V L + N+N + E T L A V ++L+ GAD+
Sbjct: 475 -LMEAAREGHEEMVALLLAQGANINAQT-EETQETALTLACCGGFSEVADFLIKAGADI- 531
Query: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
+ G PL A GH E+ + L+ GA+V+ T L A G ++ +LL+
Sbjct: 532 --ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589
Query: 772 HGADPTKK 779
GAD K+
Sbjct: 590 AGADLDKQ 597
Score = 107 bits (266), Expect = 1e-22
Identities = 108/351 (30%), Positives = 161/351 (45%), Gaps = 40/351 (11%)
Query: 181 GALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
G + L+ A G + VK L+ A+VN++ G ++ L +A G D+V+ LL G
Sbjct: 271 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEG 328
Query: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKIDVC 298
AN+ ++ G PL A S GH EV +LL GA N N + + L A KG +D+
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 299 IVLLQHGADPNIRNTDGKSALD-------------LADPSAKAVLTGEYKKDELLEAARS 345
LL+ GAD + + +AL L D A+ + + + L AA
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 346 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK-DKGGLV 404
G+ E L ALL N + TPL AA +V LLL GA+++A+ ++
Sbjct: 449 GHVE-LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 507
Query: 405 PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLV 464
L AC G EV + L+K GA + +L TPL EA+ + +E+ LL+ GA+
Sbjct: 508 ALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHAT 564
Query: 465 NCHGKSAVDMAPTPELRERLTYEFK-GHS-----LLQAAREADLAKVKKTL 509
G +A LTY + GH+ LLQA + D + KT+
Sbjct: 565 TATGDTA------------LTYACENGHTDVADVLLQAGADLDKQEDMKTI 603
Score = 105 bits (263), Expect = 2e-22
Identities = 97/320 (30%), Positives = 147/320 (45%), Gaps = 23/320 (7%)
Query: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
L+ AS G L+ VK L +VN + G +T L +A V +V+ LL+ GA++
Sbjct: 276 LMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEGANIED 333
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLK 771
++ G PL A S GH EVA +L+ HGA +N ++ +K + L A KG ++ + LL+
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 772 HGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRGDAAL-----------LDAAKKGCLARV 819
GAD K + +T L + +G ++ LL A L A G +
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-DKGGLIPLHNAA 878
L N + TPL AA + E+ LL GA++NAQ ++ L A
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 879 SYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQT 938
G ++A LIK + + TPL EA+Q+G +L LLA GA+ G T
Sbjct: 514 CGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 570
Query: 939 PLDLATAD---DIRALLIDA 955
L A + D+ +L+ A
Sbjct: 571 ALTYACENGHTDVADVLLQA 590
Score = 42.4 bits (98), Expect = 0.003
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902
A ++ LL+ G VN + G L A S G+ ++A +L+ + V + +K
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952
TPL A+ G + LLL H AD ++ G T L A A D ++ LL
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 325
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 143 bits (361), Expect = 1e-33
Identities = 139/437 (31%), Positives = 199/437 (45%), Gaps = 54/437 (12%)
Query: 184 RELLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANV 242
R L EAC +GDV+ V++L+D +VN G S L A G ++ + LL M ANV
Sbjct: 196 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEG--ESLLCLACSAGYYELAQVLLAMHANV 253
Query: 243 HAR-DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVL 301
R + G + PL A S G+ ++V LLL AD N++ T L A G +D+ VL
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 302 LQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-PLNV 360
L GA+ N +G + L+EAA +G+ E LL +
Sbjct: 314 LNEGANIEDHNENGHT--------------------PLMEAASAGHVEVARVLLDHGAGI 353
Query: 361 NCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
N H+++ ++S L LA + +V+ LL+ GAD K L AC GH EV L
Sbjct: 354 NTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARL 412
Query: 421 LLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL 480
LL GA VN +PL AA VE+ +LL+ GA+ VN D TP
Sbjct: 413 LLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVN-------DEGYTP-- 463
Query: 481 RERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLHPKRKQ 539
L++AARE V LA IN + ++ ETAL A +
Sbjct: 464 ------------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCG---GFSE 508
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
V + L++ GA++ TPL A++ H ++++ L GA ++A G TAL A
Sbjct: 509 VADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYAC 565
Query: 600 LAGHLQTCRLLLSYGSD 616
GH +LL G+D
Sbjct: 566 ENGHTDVADVLLQAGAD 582
Score = 132 bits (331), Expect = 3e-30
Identities = 139/494 (28%), Positives = 205/494 (41%), Gaps = 84/494 (17%)
Query: 286 LHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARS 345
L EA G ++ LL G N +G+S L LA + G Y+ ++L A +
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSA------GYYELAQVLLAMHA 251
Query: 346 GNEEKLMALLTPLNVNCHASDGRKS--TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGL 403
E++ G K TPL A+ + IV+LLL H ADV+++ G
Sbjct: 252 NVEDR----------------GNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGN 295
Query: 404 VPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
L AC+ G ++ ++LL GA + + TPL EAAS VEV +LL HGA
Sbjct: 296 TALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAG--- 352
Query: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
+N H EFK +L A + L V+ L +
Sbjct: 353 INTHSN-----------------EFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMH 395
Query: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
TAL A H +V LLL GA VN F +PL +AA H ++ +L + GA
Sbjct: 396 TALMEACMDGHV---EVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 452
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
+ ++ G T L AA GH + LLL+ G++ +
Sbjct: 453 LEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINA------------------------ 488
Query: 644 PIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYL 703
+T + L + G V D+E STPL A+ + +V+YL
Sbjct: 489 --QTEETQETALTLACCGGFSEVADFLIKAGA---DIELGCSTPLMEASQEGHLELVKYL 543
Query: 704 LHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKY 763
L GA+VHA G L AC GH +VA++L++ GA ++ + K + E K+
Sbjct: 544 LASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQEDMK--TILEGIDPAKH 601
Query: 764 EI------CKLLLK 771
++ CKLL K
Sbjct: 602 QVRVAFDACKLLRK 615
Score = 131 bits (329), Expect = 5e-30
Identities = 129/441 (29%), Positives = 199/441 (45%), Gaps = 59/441 (13%)
Query: 492 SLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV 551
SL +A + D+ V+K L + + E+ L A ++ + + QV LL ANV
Sbjct: 197 SLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQV---LLAMHANV 253
Query: 552 NEK-NKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLL 610
++ NK +TPL A+ + D++++L H A +N+ G TAL A G + ++L
Sbjct: 254 EDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVL 313
Query: 611 LSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLC 670
L+ G++ + G T L+EA+ AG +E + L
Sbjct: 314 LNEGANIEDHNENGHTP--------------------------LMEAASAGHVEVARVLL 347
Query: 671 S-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGH 729
+N E + S L A + +V +LL GAD K L AC GH
Sbjct: 348 DHGAGINTHSNEFKESA-LTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGH 406
Query: 730 YEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPL- 787
EVA LL+ GA VN+ AD ++ +PL AA G E+ LL++ GA+ + N +G TPL
Sbjct: 407 VEVARLLLDSGAQVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLM 465
Query: 788 DLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGY 847
+ +EG ++ LL A NIN + T+ T L LA
Sbjct: 466 EAAREGHEEMVALLLAQGA--------------------NINAQ-TEETQETALTLACCG 504
Query: 848 NNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPL 907
EVA++L++ GAD+ + G PL A+ GH+++ L+ V+AT T L
Sbjct: 505 GFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTAL 561
Query: 908 HEAAQKGRTQLCALLLAHGAD 928
A + G T + +LL GAD
Sbjct: 562 TYACENGHTDVADVLLQAGAD 582
Score = 115 bits (288), Expect = 3e-25
Identities = 104/311 (33%), Positives = 150/311 (48%), Gaps = 19/311 (6%)
Query: 650 VDYR-LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHG 707
VD R L EA GD+ V++L ++VN EG L +AGY ++ V +H
Sbjct: 193 VDTRSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHAN 252
Query: 708 ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICK 767
+ +KG + PL A S G+ ++ +LL+ H A VN T L A A G +I K
Sbjct: 253 VEDRG-NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
Query: 768 LLLKHGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRG-------------DAALLDAAKK 813
+LL GA+ N +G+TPL + G ++ +L ++AL A K
Sbjct: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
Query: 814 GCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIP 873
G L V+ L T + T L A ++EVA LL+ GA VN P
Sbjct: 372 GHLDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESP 430
Query: 874 LHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKN 933
L AA GHV++AALLI+ + + +TPL EAA++G ++ ALLLA GA+ +
Sbjct: 431 LTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT 490
Query: 934 QEGQ-TPLDLA 943
+E Q T L LA
Sbjct: 491 EETQETALTLA 501
Score = 110 bits (276), Expect = 7e-24
Identities = 127/488 (26%), Positives = 200/488 (40%), Gaps = 71/488 (14%)
Query: 306 ADPNIRNTDGKSALDLADPSAKAVL---------TGEYKKDELLEAARSGNEEKLMALLT 356
ADP + S D +A A+ G+ L EA G+ + LL
Sbjct: 156 ADPEVLRRLTSSVSCALDEAAAALTRMKAENSHNAGQVDTRSLAEACSDGDVNAVRKLLD 215
Query: 357 P-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK-DKGGLVPLHNACSYGH 414
+VN H +G L +AGY + Q+LL A+V + +KG + PL A S G+
Sbjct: 216 EGRSVNEHTEEGESLLCLACSAGY--YELAQVLLAMHANVEDRGNKGDITPLMAASSGGY 273
Query: 415 YEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDM 474
++ +LLL H A VN+ T L A + V++ +LL+ GA+ + H ++
Sbjct: 274 LDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGAN---IEDHNEN---- 326
Query: 475 APTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI--INFKQPQSHETALHCAVAS 532
GH+ L A A +V + L IN + E+AL A
Sbjct: 327 ---------------GHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYK 371
Query: 533 LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQ 592
H + LL GA+ K + T L A H +V +L GA++N +
Sbjct: 372 GH---LDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFE 428
Query: 593 TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDY 652
+ L AA GH++ LL+ G++ ++ +G+T
Sbjct: 429 SPLTLAACGGHVELAALLIERGANLEEVNDEGYTP------------------------- 463
Query: 653 RLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVH 711
L+EA++ G E V L + N+N + E T L A V ++L+ GAD+
Sbjct: 464 -LMEAAREGHEEMVALLLAQGANINAQT-EETQETALTLACCGGFSEVADFLIKAGADI- 520
Query: 712 AKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLK 771
+ G PL A GH E+ + L+ GA+V+ T L A G ++ +LL+
Sbjct: 521 --ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 578
Query: 772 HGADPTKK 779
GAD K+
Sbjct: 579 AGADLDKQ 586
Score = 107 bits (266), Expect = 1e-22
Identities = 108/351 (30%), Positives = 161/351 (45%), Gaps = 40/351 (11%)
Query: 181 GALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMG 239
G + L+ A G + VK L+ A+VN++ G ++ L +A G D+V+ LL G
Sbjct: 260 GDITPLMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEG 317
Query: 240 ANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDN-WNYTPLHEAAIKGKIDVC 298
AN+ ++ G PL A S GH EV +LL GA N N + + L A KG +D+
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
Query: 299 IVLLQHGADPNIRNTDGKSALD-------------LADPSAKAVLTGEYKKDELLEAARS 345
LL+ GAD + + +AL L D A+ + + + L AA
Sbjct: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
Query: 346 GNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK-DKGGLV 404
G+ E L ALL N + TPL AA +V LLL GA+++A+ ++
Sbjct: 438 GHVE-LAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQET 496
Query: 405 PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLV 464
L AC G EV + L+K GA + +L TPL EA+ + +E+ LL+ GA+
Sbjct: 497 ALTLACCGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHAT 553
Query: 465 NCHGKSAVDMAPTPELRERLTYEFK-GHS-----LLQAAREADLAKVKKTL 509
G +A LTY + GH+ LLQA + D + KT+
Sbjct: 554 TATGDTA------------LTYACENGHTDVADVLLQAGADLDKQEDMKTI 592
Score = 105 bits (263), Expect = 2e-22
Identities = 97/320 (30%), Positives = 147/320 (45%), Gaps = 23/320 (7%)
Query: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
L+ AS G L+ VK L +VN + G +T L +A V +V+ LL+ GA++
Sbjct: 265 LMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEGANIED 322
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNV-ADLWKFTPLHEAAAKGKYEICKLLLK 771
++ G PL A S GH EVA +L+ HGA +N ++ +K + L A KG ++ + LL+
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
Query: 772 HGADPTKKNRDGNTPL-DLVKEGDTDIQDLLRGDAAL-----------LDAAKKGCLARV 819
GAD K + +T L + +G ++ LL A L A G +
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
Query: 820 QKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ-DKGGLIPLHNAA 878
L N + TPL AA + E+ LL GA++NAQ ++ L A
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
Query: 879 SYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQT 938
G ++A LIK + + TPL EA+Q+G +L LLA GA+ G T
Sbjct: 503 CGGFSEVADFLIKAGADI---ELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDT 559
Query: 939 PLDLATAD---DIRALLIDA 955
L A + D+ +L+ A
Sbjct: 560 ALTYACENGHTDVADVLLQA 579
Score = 42.4 bits (98), Expect = 0.003
Identities = 34/114 (29%), Positives = 52/114 (45%), Gaps = 5/114 (4%)
Query: 844 AAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-NATDKW 902
A ++ LL+ G VN + G L A S G+ ++A +L+ + V + +K
Sbjct: 201 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 260
Query: 903 AFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA----DDIRALL 952
TPL A+ G + LLL H AD ++ G T L A A D ++ LL
Sbjct: 261 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLL 314
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 138 bits (347), Expect = 4e-32
Identities = 138/539 (25%), Positives = 227/539 (42%), Gaps = 81/539 (15%)
Query: 502 LAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTP 561
+ K+ + +LE+++ + T LHCAV + + + LL +GAN N +N + M P
Sbjct: 79 MEKITRDSSLEVLH-EMDDYGNTPLHCAVEK---NQIESVKFLLSRGANPNLRNFNMMAP 134
Query: 562 LHVAAERAHNDVMEVLHKHGA-KMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSII 620
LH+A + +N+VM+VL +H +N G TA+ A + + ++LL G+ P
Sbjct: 135 LHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKS 194
Query: 621 SLQG----FTAAQMGNEAVQQIL----SESTPIRTSDVDYR-------LLEASKAGDLET 665
+ G AA G++ +I+ E R +++ L A + GDLE
Sbjct: 195 NKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEM 254
Query: 666 VKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD----VHAKDKGGLVPL 721
+K +C +E T +HFAA +V+ ++ + V+ D L
Sbjct: 255 IK-MCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETML 313
Query: 722 HNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNR 781
H A + H+E+A+ L+ GA +N D +PL A A + I LLL GA K+
Sbjct: 314 HRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDN 373
Query: 782 DGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCR--------DT 833
G L L + +++L R + + K+ + CTP + CR +
Sbjct: 374 FGRNFLHLTVQQPYGLKNL-RPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNL 432
Query: 834 QGRN----------STPLHLAAGYNNLEVAEYLLEHGAD---VNAQDKGGLIPLHNAASY 880
G N +PLH AA Y + + LL+ +D +N D G+ PLH AA
Sbjct: 433 LGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKN 492
Query: 881 GHVDIAALLIKYNT---------------------------------CVNATDKWAFTPL 907
GH + LL+K C + D+ T L
Sbjct: 493 GHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTAL 552
Query: 908 HEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFK 966
H AA++G + ALLL+H AD + Q+ L LA + + +++ + + C K
Sbjct: 553 HFAAREGHAKAVALLLSHNADIVLNKQQASF-LHLALHNKRKEVVLTIIRSKRWDECLK 610
Score = 137 bits (346), Expect = 5e-32
Identities = 146/559 (26%), Positives = 250/559 (44%), Gaps = 64/559 (11%)
Query: 220 LHFAAGFGRKDVVEHLLQMGAN--VHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
LH+AA G+ +++E + + + +H DD G PLH A E V LL +GA+PN
Sbjct: 67 LHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNL 126
Query: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGA-DPNIRNTDGKSALDLA-------------D 323
R+ PLH A +V VLL+H D N+ +G +A+ +A
Sbjct: 127 RNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLK 186
Query: 324 PSAKAVLTGEYKKDELLEAARSGNEEKLMALLT-------PLNVNCHASDGRKSTPLHLA 376
AK + ++ + +AA SG++E + +L ++ + + K+TPLHLA
Sbjct: 187 KGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLA 246
Query: 377 AGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGA----CVNAMD 432
+ ++++ L +GA + +KG +H A + G E+ +L++ + VN D
Sbjct: 247 VQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD 306
Query: 433 LWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHS 492
T LH A+ + E+ L+S GAD ++ G+S + +A + +
Sbjct: 307 GCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIV------NL 360
Query: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHP---KRKQVTELLLRKGA 549
LL + D +K ++ Q + + +L P + +Q+ EL++
Sbjct: 361 LLSKGAQVD---IKDNFGRNFLHLTVQQPY------GLKNLRPEFMQMQQIKELVM---- 407
Query: 550 NVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRL 609
+++ D TPLH A + + L +++ ++ LH AA G + TC+
Sbjct: 408 ---DEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQR 464
Query: 610 LLSYGSDPSIIS---LQGFT----AAQMGNEAVQQILSESTPIRTSDVD--YRLLEASKA 660
LL SD +++ L G T AA+ G++ V Q+L + + SD + L AS
Sbjct: 465 LLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMG 524
Query: 661 GDLETVKQLCSSQNVNCRD-LEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLV 719
G +T+K + + N+ C D L+ +T LHFAA V LL H AD+ +K
Sbjct: 525 GYTQTMKVILDT-NLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADI-VLNKQQAS 582
Query: 720 PLHNACSYGHYEVAELLVR 738
LH A EV ++R
Sbjct: 583 FLHLALHNKRKEVVLTIIR 601
Score = 87.0 bits (214), Expect = 1e-16
Identities = 87/328 (26%), Positives = 132/328 (40%), Gaps = 59/328 (17%)
Query: 177 PAVSGALRELLEACRNGDVSRVKRLVDAAN-----VNAKDMAGRKSSPLHFAAGFGRKDV 231
P G + A G VK ++ + + VN D G + LH A+ F ++
Sbjct: 267 PVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTD--GCHETMLHRASLFDHHEL 324
Query: 232 VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAI 291
++L+ +GA+++ D G PL A + +V+LLL +GA + +DN+ LH
Sbjct: 325 ADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLH---- 380
Query: 292 KGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKL 351
+ + Q N+R + + + L A R G +
Sbjct: 381 -------LTVQQPYGLKNLR----PEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSV 429
Query: 352 MALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKG---GLVPLHN 408
LL NV+ H+ K +PLH AA Y R+ Q LLQ +D ++G G+ PLH
Sbjct: 430 NNLL-GFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHL 488
Query: 409 ACSYGHYEVTELLLKHGA---------------------------------CVNAMDLWQ 435
A GH +V +LLLK GA C + +D
Sbjct: 489 AAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDG 548
Query: 436 FTPLHEAASKNRVEVCSLLLSHGADPTL 463
T LH AA + + +LLLSH AD L
Sbjct: 549 NTALHFAAREGHAKAVALLLSHNADIVL 576
>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
[Homo sapiens]
Length = 1170
Score = 135 bits (339), Expect = 3e-31
Identities = 186/787 (23%), Positives = 300/787 (38%), Gaps = 121/787 (15%)
Query: 229 KDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD-NWNYTPLH 287
+ + L+ A+V D G LH G + L+ GA NA TPLH
Sbjct: 269 ESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLH 328
Query: 288 EAAI----KGKIDVCI-------VLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
A+ K DV LLQ GA+PN++++ G++ L ++ + + + +
Sbjct: 329 LVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQ 388
Query: 337 DELLEAARSGNEEKLMALLTPLNVNCHASDGR---KSTPLHLAAGYNRVRIVQLLLQHGA 393
+ L+ +E L ++ + + P+ ++ L+Q G+
Sbjct: 389 CKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGS 448
Query: 394 DVHAKDKG-GLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCS 452
A D G L A G+ L +GA VN + W TPLH A + +
Sbjct: 449 HTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTA 508
Query: 453 LLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALE 512
LL GA+P L + E L + SL A L
Sbjct: 509 ELLQQGANPNL---------------QTEEALPLPKEAASLTSLADSVHL---------- 543
Query: 513 IINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANV-------------NEKNKDFM 559
+T LH A+A HP V ++L + AN + K+
Sbjct: 544 ----------QTPLHMAIAYNHP---DVVSVILEQKANALHATNNLQIIPDFSLKDSRDQ 590
Query: 560 TPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSI 619
T L +A + + L GA +N + GQT LH A ++ LL + +D ++
Sbjct: 591 TVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINV 650
Query: 620 ISLQ-GFTAAQMGNEAVQQILSESTPIRTSDVDYR------LLEASKAGDLETVKQLCSS 672
Q G TA Q+ ++ ++ R +D+ L + A +LE +
Sbjct: 651 SRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVR 710
Query: 673 QNVNCR----DLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA------------KDKG 716
+ G T LH A N +L+ G DV++ + +
Sbjct: 711 HGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARD 770
Query: 717 GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH-GAD 775
G PLH A S+G E + L+ GA+VN D TP+H A + I +LL+ H
Sbjct: 771 GQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIH 830
Query: 776 PTKKNRDGNTPLD--LVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDT 833
++R G TP + + + + +L+ ++ + D
Sbjct: 831 LNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQV--------------------DN 870
Query: 834 QGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA--QDKGGLIPLHNAASYGHVDIAALLIK 891
+GRN LH+A +++E +L+ A+VN+ QD L PLH A G I L+
Sbjct: 871 KGRNF--LHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLL 928
Query: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT----ADD 947
VN K T LH AAQ+ +C++LL +G D ++ G L LA ++
Sbjct: 929 AGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNN 988
Query: 948 IRALLID 954
IR LL +
Sbjct: 989 IRVLLTE 995
Score = 129 bits (324), Expect = 2e-29
Identities = 207/857 (24%), Positives = 324/857 (37%), Gaps = 131/857 (15%)
Query: 185 ELLEACRNGDVS-------RVKRLVDA-----ANVNAKDMAGRKSSPLHFAAGFGRKDVV 232
+L EA NGD++ R++ + A+V+ D +G S LH G
Sbjct: 248 KLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGW--SLLHKGIQRGDLFAA 305
Query: 233 EHLLQMGANVHARDDGGL-IPLHNACSFGH-----------AEVVSLLLCQGADPNARDN 280
L++ GA V+A G PLH + A++ LL GA+PN +D+
Sbjct: 306 TFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDS 365
Query: 281 WNYTPLHEAAIKGKIDVCIVLLQ-HGADPNIRNTDGKSALDLADPSAKAVLTGEYK--KD 337
TPLH + + G V LLQ D +++ +G +AL LA +D
Sbjct: 366 KGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFED 425
Query: 338 ELLEAARSGNEEKLMALLTPLNVNCHASD-GRKSTPLHLAAGYNRVRIVQLLLQHGADVH 396
+ S +E A L + A D + L AAG L +GA V+
Sbjct: 426 VPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVN 485
Query: 397 AKDKGGLVPLHNACSYGHYEVTELLLKHGACVN-------------------AMDLWQFT 437
++K G PLH AC +G +T LL+ GA N A + T
Sbjct: 486 HRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQT 545
Query: 438 PLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ-- 495
PLH A + N +V S++L A+ H + + + P L++ G +L
Sbjct: 546 PLHMAIAYNHPDVVSVILEQKANAL----HATNNLQIIPDFSLKDSRDQTVLGLALWTGM 601
Query: 496 -----------AAREADLAKVKKTLALEI-----------------INFKQPQSHETALH 527
AA ++ + L + I IN + Q ETAL
Sbjct: 602 HTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQ 661
Query: 528 CAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNAL 587
A+ + P V + + +GA+++ ++ PL +A D+ L +HG
Sbjct: 662 LAIRNQLPL---VVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCW 718
Query: 588 DT----LGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
QT LHRA + T L+ G D + G E ++ T
Sbjct: 719 GPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPG-----ANGEGEEEARDGQT 773
Query: 644 PIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEY 702
P+ A+ G ETV+ L NVN +D EGR TP+H A +++
Sbjct: 774 PLHL---------AASWGLEETVQCLLEFGANVNAQDAEGR--TPIHVAISSQHGVIIQL 822
Query: 703 LLHHGADVH--AKDKGGLVPLHNACSYGHYEVAE-LLVRHGASVNVADLWKFTPLHEAAA 759
L+ H D+H +D+ GL P A ++ + + AE +L R + D LH A
Sbjct: 823 LVSH-PDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQ 881
Query: 760 KGKYEICKLLLKHGADPTKKNRDGN--TPLDLVKEGDTDI------------QDLLRGDA 805
E L+ A+ + +D + TPL L + ++I +L +
Sbjct: 882 NSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQ 941
Query: 806 ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLL-EHGADVN 864
L A + L + + ++ + LHLA + L LL E D
Sbjct: 942 TALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRVLLTECTVDAE 1001
Query: 865 AQDKGGLIPLHNAASYGHVDIAALLIKYNTCV-----NATDKWAFTPLHEAAQKGRTQLC 919
A + G PLH YG + AA+ + C+ + D T L A KG LC
Sbjct: 1002 AFNLRGQSPLHILGQYGKENAAAIFDLFLECMPGYPLDKPDADGSTVLLLAYMKGNANLC 1061
Query: 920 ALLLAHGADPTMKNQEG 936
++ GA + N +G
Sbjct: 1062 RAIVRSGARLGVNNNQG 1078
Score = 108 bits (269), Expect = 4e-23
Identities = 165/651 (25%), Positives = 247/651 (37%), Gaps = 76/651 (11%)
Query: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
+D L LA I L+ H ADV DK G LH G L+K+
Sbjct: 252 ADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKN 311
Query: 425 GACVNAMDLW-QFTPLHEAA-----------SKNRVEVCSLLLSHGADPTLVNCHGKSAV 472
GA VNA L Q TPLH A ++ LL GA+P + + G++ +
Sbjct: 312 GAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPL 371
Query: 473 DMAPTPELRERLTYEFKGHSLLQAAREADL------AKVKKTLALEIINFKQPQSHETAL 526
++ + Y F S L ++ DL LA++ I QS
Sbjct: 372 HVS----IMAGNEYVF---SQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFE 424
Query: 527 HCAVAS-LHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEV-LHKHGAKM 584
V + L+++G++ + + L A A N+ + L +GA +
Sbjct: 425 DVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHV 484
Query: 585 NALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQI-LSEST 643
N + G+T LH A G LL G++P+ LQ A + EA L++S
Sbjct: 485 NHRNKWGETPLHTACRHGLANLTAELLQQGANPN---LQTEEALPLPKEAASLTSLADSV 541
Query: 644 PIRTS----------DVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAG 693
++T DV +LE KA L L + + +D R T L A
Sbjct: 542 HLQTPLHMAIAYNHPDVVSVILE-QKANALHATNNLQIIPDFSLKD--SRDQTVLGLALW 598
Query: 694 YNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753
++ LL GA ++ G LH A + A L+ H A +NV+
Sbjct: 599 TGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGET 658
Query: 754 LHEAAAKGKYE-ICKLLLKHGADPTKKNRDGNTPLDLVKEGDTD--IQDLLRG--DAALL 808
+ A + + + + GAD + + GN PL L + + L+R DA
Sbjct: 659 ALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCW 718
Query: 809 DAAKKGCLARVQKLCTPEN--------------INCRDTQGRNS----------TPLHLA 844
GCL + EN +N G N TPLHLA
Sbjct: 719 GPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLA 778
Query: 845 AGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY-NTCVNATDKWA 903
A + E + LLE GA+VNAQD G P+H A S H I LL+ + + +N D+
Sbjct: 779 ASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQG 838
Query: 904 FTPLHEAAQ-KGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD-DIRALL 952
TP A K A+L + +G+ L +A + DI ++L
Sbjct: 839 LTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVL 889
Score = 84.7 bits (208), Expect = 5e-16
Identities = 94/318 (29%), Positives = 131/318 (41%), Gaps = 45/318 (14%)
Query: 171 GPGTGVPAVSGALRELLE----------AC---RNG-DVSRVKRLVDAANVNAKDMAGRK 216
GPG G G L+ LL AC R+G DV+ ++ AN ++ A
Sbjct: 719 GPGPG-----GCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQ--PGANGEGEEEARDG 771
Query: 217 SSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQ-GADP 275
+PLH AA +G ++ V+ LL+ GANV+A+D G P+H A S H ++ LL+
Sbjct: 772 QTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHL 831
Query: 276 NARDNWNYTPLHEAAI--KGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGE 333
N RD TP A K I+ + GA + N G++ L +A
Sbjct: 832 NVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDN-KGRNFLHVA----------- 879
Query: 334 YKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGA 393
S E L + NVN D K TPLHLA IV+ LL GA
Sbjct: 880 --------VQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGA 931
Query: 394 DVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 453
V+ K LH A + +LL++G A+D LH A R+ +
Sbjct: 932 KVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNALHLAVMHGRLNNIRV 991
Query: 454 LLSH-GADPTLVNCHGKS 470
LL+ D N G+S
Sbjct: 992 LLTECTVDAEAFNLRGQS 1009
Score = 77.4 bits (189), Expect = 8e-14
Identities = 113/469 (24%), Positives = 183/469 (39%), Gaps = 44/469 (9%)
Query: 532 SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLG 591
+L + + + L+ A+V+ +K + LH +R L K+GA +NA TLG
Sbjct: 263 ALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA-TLG 321
Query: 592 --QTALHRAALAGH-----------LQTCRLLLSYGSDPSIISLQGFTAAQM----GNEA 634
+T LH AL Q LL G++P++ +G T + GNE
Sbjct: 322 AQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEY 381
Query: 635 VQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGY 694
V S+ + D++ + E S A L V+ + S + + E P+ +
Sbjct: 382 V---FSQLLQCKQLDLELKDHEGSTALWL-AVQHITVSSDQSVNPFE---DVPVVNGTSF 434
Query: 695 NRVSVVEYLLHHGADVHAKDKG-GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTP 753
+ S L+ G+ A D G L A G+ A L +GA VN + W TP
Sbjct: 435 DENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETP 494
Query: 754 LHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAA-- 811
LH A G + LL+ GA+P + + PL T + D + L A
Sbjct: 495 LHTACRHGLANLTAELLQQGANPNLQTEEA-LPLPKEAASLTSLADSVHLQTPLHMAIAY 553
Query: 812 ------------KKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEH 859
K L L + + +D+ R+ T L LA +A LL
Sbjct: 554 NHPDVVSVILEQKANALHATNNLQIIPDFSLKDS--RDQTVLGLALWTGMHTIAAQLLGS 611
Query: 860 GADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNAT-DKWAFTPLHEAAQKGRTQL 918
GA +N G LH A A L+++ +N + + T L A + +
Sbjct: 612 GAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLV 671
Query: 919 CALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKP 967
+ GAD ++ +++G PL LA A+++ + + TC+ P
Sbjct: 672 VDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP 720
Score = 66.2 bits (160), Expect = 2e-10
Identities = 83/315 (26%), Positives = 125/315 (39%), Gaps = 50/315 (15%)
Query: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLW-KFTPLHE 756
S+ L+ H ADV DK G LH G A L+++GA VN A L + TPLH
Sbjct: 270 SIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHL 329
Query: 757 AAAKGKY-----------EICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA 805
A +I + LL+ GA+P ++ G TPL + ++ G+
Sbjct: 330 VALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHV---------SIMAGNE 380
Query: 806 ALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 865
+ + C ++ +D +G ST L LA V + VN
Sbjct: 381 YVFSQLLQ---------CKQLDLELKDHEG--STALWLA-------VQHITVSSDQSVNP 422
Query: 866 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLA- 924
+ +P+ N S+ AA LI+ + +A D L + A + AL LA
Sbjct: 423 FED---VPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLAT 479
Query: 925 HGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALPTCFKPQATVVSASLISPASTPS 984
+GA +N+ G+TPL A + L + + A P +A L P S
Sbjct: 480 NGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEA------LPLPKEAAS 533
Query: 985 CLSAASSIDNLTGPL 999
S A S+ +L PL
Sbjct: 534 LTSLADSV-HLQTPL 547
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 134 bits (338), Expect = 4e-31
Identities = 132/442 (29%), Positives = 194/442 (43%), Gaps = 64/442 (14%)
Query: 323 DPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRV 382
+PS + T + +K +L++A SG+ KLM +L P +V+ G ++ LHLA +
Sbjct: 394 EPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSG--ASLLHLAVEAGQE 451
Query: 383 RIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442
+ LL + A+ + ++ G PLH A V ELLL VNA D Q+T LH A
Sbjct: 452 ECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFA 511
Query: 443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADL 502
A LLL A V+ G++ + H Q +E ++
Sbjct: 512 AQNGDESSTRLLLEKNASVNEVDFEGRTPM------------------HVACQHGQE-NI 552
Query: 503 AKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRK-GANVNEKNKDFMTP 561
++ +++ Q + LH A H + +LL ++ G +VN + D TP
Sbjct: 553 VRILLRRGVDVS--LQGKDAWLPLHYAAWQGH---LPIVKLLAKQPGVSVNAQTLDGRTP 607
Query: 562 LHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS 621
LH+AA+R H V +L + +N L QT LH AA GH T RLLL G+ ++
Sbjct: 608 LHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMT 667
Query: 622 LQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLE 681
G+TA + A++ G L TVK L + D+
Sbjct: 668 SDGYTALHL--------------------------AARNGHLATVKLLVEEK----ADVL 697
Query: 682 GR---HSTPLHFAAGYNRVSVVEYLLHHGADV-HAKDKGGLVPLHNACSYGHYEVAELLV 737
R + T LH AA + VVE L+ ADV D+ GL LH A H + E L+
Sbjct: 698 ARGPLNQTALHLAAAHGHSEVVEELV--SADVIDLFDEQGLSALHLAAQGRHAQTVETLL 755
Query: 738 RHGASVNVADLWKFTPLHEAAA 759
RHGA +N+ L KF H AA
Sbjct: 756 RHGAHINLQSL-KFQGGHGPAA 776
Score = 132 bits (331), Expect = 3e-30
Identities = 128/422 (30%), Positives = 178/422 (42%), Gaps = 65/422 (15%)
Query: 468 GKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALH 527
G ++ P + T + + L+ A D +K+ K L QPQ + AL
Sbjct: 385 GSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMKIL--------QPQDVDLALD 436
Query: 528 CAVASLH----PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
+ LH +++ + LL AN N N+ TPLH+A ER V+E+L
Sbjct: 437 SGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKIS 496
Query: 584 MNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AAQMGNEAVQQIL 639
+NA D TALH AA G + RLLL + + + +G T A Q G E + +IL
Sbjct: 497 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 640 SESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS-TPLHFAAGYNRVS 698
R DV L+G+ + PLH+AA +
Sbjct: 557 LR----RGVDVS----------------------------LQGKDAWLPLHYAAWQGHLP 584
Query: 699 VVEYLLHH-GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
+V+ L G V+A+ G PLH A GHY VA +L+ + VNV L TPLH A
Sbjct: 585 IVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVA 644
Query: 758 AAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG----------DTDIQDLLRG---D 804
A G +LLL GA DG T L L + L RG
Sbjct: 645 AETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQ 704
Query: 805 AALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVN 864
AL AA G V++L + + I+ D QG ++ LHLAA + + E LL HGA +N
Sbjct: 705 TALHLAAAHGHSEVVEELVSADVIDLFDEQGLSA--LHLAAQGRHAQTVETLLRHGAHIN 762
Query: 865 AQ 866
Q
Sbjct: 763 LQ 764
Score = 126 bits (317), Expect = 1e-28
Identities = 126/461 (27%), Positives = 196/461 (42%), Gaps = 55/461 (11%)
Query: 128 SPSSSSSPTSSSSSSPSSPGSSLAESPEAA--GVSSTAPLGPGAAGPGTGVPAVSGALRE 185
S SSS S SS S G S +S ++ +S + P + GT ++
Sbjct: 354 SRSSSESKLPSSGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGT----TDVQKKK 409
Query: 186 LLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHAR 245
L++A +GD S++ +++ +V+ +G +S LH A G+++ + LL AN +
Sbjct: 410 LVDAIVSGDTSKLMKILQPQDVDLALDSG--ASLLHLAVEAGQEECAKWLLLNNANPNLS 467
Query: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305
+ G PLH A VV LLL + NA+D +T LH AA G +LL+
Sbjct: 468 NRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN 527
Query: 306 ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHAS 365
A N + +G++ + A +E ++ +L V+
Sbjct: 528 ASVNEVDFEGRTP---------------------MHVACQHGQENIVRILLRRGVDVSLQ 566
Query: 366 DGRKSTPLHLAAGYNRVRIVQLLL-QHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
PLH AA + IV+LL Q G V+A+ G PLH A GHY V +L+
Sbjct: 567 GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDL 626
Query: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484
+ VN L TPLH AA LLL GA + G +A+ +
Sbjct: 627 CSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHL---------- 676
Query: 485 TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELL 544
AAR LA VK + + + ++TALH A A H +V E L
Sbjct: 677 -----------AARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGH---SEVVEEL 722
Query: 545 LRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
+ ++ ++ ++ LH+AA+ H +E L +HGA +N
Sbjct: 723 VSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 124 bits (310), Expect = 8e-28
Identities = 113/380 (29%), Positives = 171/380 (45%), Gaps = 40/380 (10%)
Query: 573 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGN 632
+M++L + ALD+ G + LH A AG + + LL ++P++ + +G T M
Sbjct: 422 LMKILQPQDVDL-ALDS-GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
Query: 633 E-----AVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRH 684
E V+ +L+ + D D L A++ GD + + L +VN D EGR
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGR- 538
Query: 685 STPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH-GASV 743
TP+H A + + ++V LL G DV + K +PLH A GH + +LL + G SV
Sbjct: 539 -TPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSV 597
Query: 744 NVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLR 802
N L TPLH AA +G Y + ++L+ +D + TPL + E G T LL
Sbjct: 598 NAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLL 657
Query: 803 GDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
A +A T LHLAA +L + L+E AD
Sbjct: 658 HRGAGKEAMTSD----------------------GYTALHLAARNGHLATVKLLVEEKAD 695
Query: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922
V A+ LH AA++GH ++ L+ + ++ D+ + LH AAQ Q L
Sbjct: 696 VLARGPLNQTALHLAAAHGHSEVVEELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETL 754
Query: 923 LAHGAD---PTMKNQEGQTP 939
L HGA ++K Q G P
Sbjct: 755 LRHGAHINLQSLKFQGGHGP 774
Score = 116 bits (290), Expect = 2e-25
Identities = 114/351 (32%), Positives = 147/351 (41%), Gaps = 39/351 (11%)
Query: 609 LLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTP-----IRTSDVDYRLLE------- 656
L LS+ +PS L G T Q + V I+S T ++ DVD L
Sbjct: 387 LSLSFEREPSTSDL-GTTDVQK-KKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHL 444
Query: 657 ASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKG 716
A +AG E K L + N N R STPLH A VVE LL V+AKD+
Sbjct: 445 AVEAGQEECAKWLLLN-NANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDED 503
Query: 717 GLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADP 776
LH A G LL+ ASVN D TP+H A G+ I ++LL+ G D
Sbjct: 504 QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
Query: 777 TKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE--NINCRDTQ 834
+ + +D PL AA +G L V+ L ++N +
Sbjct: 564 SLQGKDAWLPLHY--------------------AAWQGHLPIVKLLAKQPGVSVNAQTLD 603
Query: 835 GRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT 894
GR TPLHLAA + VA L++ +DVN PLH AA GH A LL+
Sbjct: 604 GR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGA 661
Query: 895 CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945
A +T LH AA+ G LL+ AD + QT L LA A
Sbjct: 662 GKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAA 712
Score = 67.0 bits (162), Expect = 1e-10
Identities = 61/203 (30%), Positives = 91/203 (44%), Gaps = 27/203 (13%)
Query: 206 NVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVV 265
+VNA+ + GR +PLH AA G V L+ + ++V+ PLH A GH
Sbjct: 596 SVNAQTLDGR--TPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTA 653
Query: 266 SLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPS 325
LLL +GA A + YT LH AA G + +L++ AD R ++AL L
Sbjct: 654 RLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHL---- 709
Query: 326 AKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIV 385
AA G+ E + L++ ++ G + LHLAA + V
Sbjct: 710 ----------------AAAHGHSEVVEELVSADVIDLFDEQGLSA--LHLAAQGRHAQTV 751
Query: 386 QLLLQHGADVH---AKDKGGLVP 405
+ LL+HGA ++ K +GG P
Sbjct: 752 ETLLRHGAHINLQSLKFQGGHGP 774
Score = 35.0 bits (79), Expect = 0.48
Identities = 15/46 (32%), Positives = 26/46 (56%)
Query: 907 LHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALL 952
LH A + G+ + LL + A+P + N+ G TPL +A +R ++
Sbjct: 442 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVV 487
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 132 bits (332), Expect = 2e-30
Identities = 111/302 (36%), Positives = 139/302 (46%), Gaps = 14/302 (4%)
Query: 169 AAGPGTGVPAVSGALRELLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFG 227
A G T P+V LL+A G V +L+ A+V +D AGR +PLH A G
Sbjct: 28 ALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRG 85
Query: 228 RKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLH 287
+V LLQ GA V A D G LH A GH+ V LLL +GA AR TPLH
Sbjct: 86 HAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLH 145
Query: 288 EAAIKGKIDVCIVLLQ-HGADPNIRNTDGKSALDLADPSAK----AVLT-----GEYKKD 337
AA G + LL+ G P + A +A AVL G
Sbjct: 146 WAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDG 205
Query: 338 ELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
LL AA +G L LL A DG +T L LAA R + +++LL HGAD
Sbjct: 206 ALLVAAAAGRGAALRFLLA-RGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGI 264
Query: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
+D+ G LH A + GH +LL+ GA V+A D TPLH A+ + VEV LL
Sbjct: 265 RDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDR 324
Query: 458 GA 459
GA
Sbjct: 325 GA 326
Score = 129 bits (325), Expect = 1e-29
Identities = 116/361 (32%), Positives = 161/361 (44%), Gaps = 53/361 (14%)
Query: 544 LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGH 603
LLR+GA+V E++ TPLH+A R H ++ +L + GA + A+D G+TALH AA GH
Sbjct: 60 LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
Query: 604 LQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDL 663
+ LLL G+ + S G T +L+ RLLEA G
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAA-----------RLLEAPGPGPA 168
Query: 664 ETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHN 723
+ + R T H+AA R++V+E L GA + G L+
Sbjct: 169 AAEAE------------DARGWTAAHWAAAGGRLAVLELLAAGGAGLD----GALLV--- 209
Query: 724 ACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDG 783
A + G L+ GA V+ D T L AAA G+ + ++LL HGADP ++R G
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHG 269
Query: 784 NTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLH 842
+ AL AA +G L VQ L T ++ RDT G TPLH
Sbjct: 270 RS--------------------ALHRAAARGHLLAVQLLVTQGAEVDARDTLGL--TPLH 307
Query: 843 LAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKW 902
A+ ++EVA LL+ GA V+A PLH AA GH LL+ +W
Sbjct: 308 HASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQW 367
Query: 903 A 903
A
Sbjct: 368 A 368
Score = 124 bits (310), Expect = 8e-28
Identities = 106/302 (35%), Positives = 136/302 (45%), Gaps = 16/302 (5%)
Query: 654 LLEASKAGDLETVKQLC-SSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
LL+A G V QL +V RD GR TPLH A +V LL GA V A
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGR--TPLHLAVLRGHAPLVRLLLQRGAPVGA 102
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
D+ G LH A +GH VAELL++ GAS TPLH AAA G + LL+
Sbjct: 103 VDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEA 162
Query: 773 -----GADPTKKNRDGNTPLDLVKEGDTDIQDLLRG-----DAALLDAAKKGCLARVQ-K 821
A + R G + +LL D ALL AA G A ++
Sbjct: 163 PGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFL 222
Query: 822 LCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYG 881
L ++ RD G +T L LAA + E LL HGAD +D+ G LH AA+ G
Sbjct: 223 LARGARVDARD--GAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARG 280
Query: 882 HVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLD 941
H+ LL+ V+A D TPLH A+++G ++ LL GA +TPL
Sbjct: 281 HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLH 340
Query: 942 LA 943
LA
Sbjct: 341 LA 342
Score = 99.8 bits (247), Expect = 2e-20
Identities = 87/254 (34%), Positives = 119/254 (46%), Gaps = 12/254 (4%)
Query: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA 430
TPLHLA +V+LLLQ GA V A D+ G LH A +GH V ELLL+ GA A
Sbjct: 76 TPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAA 135
Query: 431 MDLWQFTPLHEAASKNRVEVCSLLL-SHGADPTLV---NCHGKSAVDMAPTPELRERLTY 486
TPLH AA+ + + LL + G P + G +A A L
Sbjct: 136 RSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLEL 195
Query: 487 EFKG-----HSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVT 541
G +LL AA A ++ LA + + TAL A A R Q
Sbjct: 196 LAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAAL---GRSQDI 252
Query: 542 ELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALA 601
E+LL GA+ +++ + LH AA R H +++L GA+++A DTLG T LH A+
Sbjct: 253 EVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASRE 312
Query: 602 GHLQTCRLLLSYGS 615
GH++ LL G+
Sbjct: 313 GHVEVAGCLLDRGA 326
Score = 94.7 bits (234), Expect = 5e-19
Identities = 111/381 (29%), Positives = 162/381 (42%), Gaps = 46/381 (12%)
Query: 275 PNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEY 334
P+ W + L +A +G + LL+ GA R+ G++ L LA VL G
Sbjct: 36 PSVVQGWGH--LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLA------VLRGH- 86
Query: 335 KKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGAD 394
L+ LL A D T LH AA + R+ +LLLQ GA
Sbjct: 87 --------------APLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGAS 132
Query: 395 VHAKDKGGLVPLHNACSYGHYEVTELLLKHG----ACVNAMDLWQFTPLHEAASKNRVEV 450
A+ GL PLH A + GH + LL+ A A D +T H AA+ R+ V
Sbjct: 133 AAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAV 192
Query: 451 CSLLLSHGA--DPTLV--NCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVK 506
LL + GA D L+ G+ A + G + L A A +
Sbjct: 193 LELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLA-----AALG 247
Query: 507 KTLALEIINFK------QPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMT 560
++ +E++ + + +ALH A A H +LL+ +GA V+ ++ +T
Sbjct: 248 RSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH---LLAVQLLVTQGAEVDARDTLGLT 304
Query: 561 PLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSII 620
PLH A+ H +V L GA+++A L +T LH AA GH T LLLS G+ P+ +
Sbjct: 305 PLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPT-L 363
Query: 621 SLQGFTAAQMGNEAVQQILSE 641
Q AQM + Q L E
Sbjct: 364 RTQWAEVAQMPEGDLPQALPE 384
Score = 81.6 bits (200), Expect = 4e-15
Identities = 87/268 (32%), Positives = 108/268 (40%), Gaps = 36/268 (13%)
Query: 173 GTGVPAVSGA-LRELLEACRNGDVSRVKRLVDA-----ANVNAKDMAGRKSSPLHFAAGF 226
G A SG L L A G RL++A A A+D G ++ H+AA
Sbjct: 130 GASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAA--HWAAAG 187
Query: 227 GRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286
GR V+E L GA + DG L+ A + G + LL +GA +ARD T L
Sbjct: 188 GRLAVLELLAAGGAGL----DGALLV---AAAAGRGAALRFLLARGARVDARDGAGATAL 240
Query: 287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSG 346
AA G+ VLL HGADP IR+ G+SAL AA G
Sbjct: 241 GLAAALGRSQDIEVLLGHGADPGIRDRHGRSALH--------------------RAAARG 280
Query: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
+ + L+T A D TPLH A+ V + LL GA V A PL
Sbjct: 281 HLLAVQLLVTQ-GAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPL 339
Query: 407 HNACSYGHYEVTELLLKHGACVNAMDLW 434
H A GH LLL GA W
Sbjct: 340 HLAAERGHGPTVGLLLSRGASPTLRTQW 367
Score = 63.9 bits (154), Expect = 1e-09
Identities = 36/90 (40%), Positives = 46/90 (51%)
Query: 856 LLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915
LL GA V +D G PLH A GH + LL++ V A D+ T LHEAA G
Sbjct: 60 LLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGH 119
Query: 916 TQLCALLLAHGADPTMKNQEGQTPLDLATA 945
+++ LLL GA ++ G TPL A A
Sbjct: 120 SRVAELLLQRGASAAARSGTGLTPLHWAAA 149
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 124 bits (312), Expect = 5e-28
Identities = 92/295 (31%), Positives = 140/295 (47%), Gaps = 26/295 (8%)
Query: 654 LLEASKAGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHA 712
LL A+ G+++ ++ L ++ +D G S +++AA + V +++L + +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGG--SNAVYWAARHGHVDTLKFLSENKCPLDV 440
Query: 713 KDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKH 772
KDK G + LH A YGH +VA+LL G++ N+ D + TPLH AA G Y + K L +
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 773 GADPTKKNRDGNTP-LDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCR 831
G + KNR+G TP L G DI + L A L+A K
Sbjct: 501 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKD----------------- 543
Query: 832 DTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
LHLA +EV + LL G V+ QD+ G PLH A G++ I L +
Sbjct: 544 -----GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCE 598
Query: 892 YNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD 946
N ++ ++K+ TPLH AA G + L GA +G+T DLA ++
Sbjct: 599 ANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSE 653
Score = 121 bits (303), Expect = 5e-27
Identities = 112/414 (27%), Positives = 169/414 (40%), Gaps = 65/414 (15%)
Query: 480 LRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQ 539
L +RL+ F S + AR D + + ++ I + L + SL
Sbjct: 314 LCQRLSRSFLSRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSL------ 367
Query: 540 VTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAA 599
+VN+ NK PL +AA + ++++L K G++++ D G A++ AA
Sbjct: 368 -------SNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAA 420
Query: 600 LAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASK 659
GH+ T + L + G A + A++
Sbjct: 421 RHGHVDTLKFLSENKCPLDVKDKSGEMALHV--------------------------AAR 454
Query: 660 AGDLETVKQLCS-SQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGL 718
G + + LCS N N +D E TPLH AA + SV + L G +V+ K++ G
Sbjct: 455 YGHADVAQLLCSFGSNPNIQDKE--EETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGE 512
Query: 719 VPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTK 778
PL A + G++++ E L HGA +N D LH A + + E+ K LL G
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDY 572
Query: 779 KNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE-NINCRDTQGRN 837
++R GNTPL + A K G + V LC N++ + GR
Sbjct: 573 QDRHGNTPLHV--------------------ACKDGNMPIVVALCEANCNLDISNKYGR- 611
Query: 838 STPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIK 891
TPLHLAA L+V YL GA V A G A S H +A LL +
Sbjct: 612 -TPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664
Score = 113 bits (283), Expect = 1e-24
Identities = 83/287 (28%), Positives = 133/287 (46%), Gaps = 28/287 (9%)
Query: 683 RHSTP-LHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGA 741
+H TP L AAG + +++ L+ G+ + +DKGG ++ A +GH + + L +
Sbjct: 377 KHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKC 436
Query: 742 SVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLL 801
++V D LH AA G ++ +LL G++P ++++ TPL
Sbjct: 437 PLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHC------------ 484
Query: 802 RGDAALLDAAKKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHG 860
AA G + + LC N+N ++ +G TPL A+ ++ E L EHG
Sbjct: 485 --------AAWHGYYSVAKALCEAGCNVNIKNREG--ETPLLTASARGYHDIVECLAEHG 534
Query: 861 ADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCA 920
AD+NA DK G I LH A +++ L+ V+ D+ TPLH A + G +
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVV 594
Query: 921 LLLAHGADPTMKNQEGQTPLDLAT----ADDIRALLIDAMPPEALPT 963
L + + N+ G+TPL LA D +R L + EAL T
Sbjct: 595 ALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTT 641
Score = 109 bits (272), Expect = 2e-23
Identities = 81/291 (27%), Positives = 138/291 (47%), Gaps = 24/291 (8%)
Query: 186 LLEACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
LL A G++ ++ L+ + ++ +D G S+ +++AA G D ++ L + +
Sbjct: 383 LLIAAGCGNIQILQLLIKRGSRIDVQDKGG--SNAVYWAARHGHVDTLKFLSENKCPLDV 440
Query: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
+D G + LH A +GHA+V LL G++PN +D TPLH AA G V L +
Sbjct: 441 KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 500
Query: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
G + NI+N +G++ L L +AR ++ ++ L + +A
Sbjct: 501 GCNVNIKNREGETPL-------------------LTASARGYHD--IVECLAEHGADLNA 539
Query: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
D LHLA ++ +++ LL G V +D+ G PLH AC G+ + L +
Sbjct: 540 CDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEA 599
Query: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475
++ + + TPLH AA+ ++V L GA + GK+A D+A
Sbjct: 600 NCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
Score = 99.8 bits (247), Expect = 2e-20
Identities = 99/346 (28%), Positives = 146/346 (42%), Gaps = 53/346 (15%)
Query: 394 DVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSL 453
DV+ +K G PL A G+ ++ +LL+K G+ ++ D ++ AA V+
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKF 430
Query: 454 LLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI 513
L + + + G+ A+ +A GH AD+A++ +
Sbjct: 431 LSENKCPLDVKDKSGEMALHVAAR-----------YGH--------ADVAQLLCSFGSNP 471
Query: 514 INFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDV 573
N Q + ET LHCA + V + L G NVN KN++ TPL A+ R ++D+
Sbjct: 472 -NI-QDKEEETPLHCAAWHGY---YSVAKALCEAGCNVNIKNREGETPLLTASARGYHDI 526
Query: 574 MEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNE 633
+E L +HGA +NA D G ALH A ++ + LLS G G
Sbjct: 527 VECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHG--------- 577
Query: 634 AVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ-NVNCRDLEGRHSTPLHFAA 692
+TP+ A K G++ V LC + N++ + GR TPLH AA
Sbjct: 578 --------NTPLHV---------ACKDGNMPIVVALCEANCNLDISNKYGR--TPLHLAA 618
Query: 693 GYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVR 738
+ VV YL GA V A G A S H VA LL R
Sbjct: 619 NNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 664
Score = 93.6 bits (231), Expect = 1e-18
Identities = 78/308 (25%), Positives = 135/308 (43%), Gaps = 22/308 (7%)
Query: 180 SGALRELLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQM 238
S ++ ++ A + +V ++ L+ + +N + + PL AAG G +++ L++
Sbjct: 342 SFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKR 401
Query: 239 GANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVC 298
G+ + +D GG ++ A GH + + L + +D LH AA G DV
Sbjct: 402 GSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVA 461
Query: 299 IVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPL 358
+L G++PNI++ + ++ L A G Y + L A
Sbjct: 462 QLLCSFGSNPNIQDKEEETPLHCA------AWHGYYSVAKALCEAGC------------- 502
Query: 359 NVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVT 418
NVN +G TPL A+ IV+ L +HGAD++A DK G + LH A EV
Sbjct: 503 NVNIKNREGE--TPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVI 560
Query: 419 ELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP 478
+ LL G V+ D TPLH A + + L + + N +G++ + +A
Sbjct: 561 KTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANN 620
Query: 479 ELRERLTY 486
+ + + Y
Sbjct: 621 GILDVVRY 628
Score = 85.9 bits (211), Expect = 2e-16
Identities = 90/346 (26%), Positives = 135/346 (39%), Gaps = 51/346 (14%)
Query: 274 DPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGE 333
D N + PL AA G I + +L++ G+ ++++ G +A+
Sbjct: 371 DVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAV-------------- 416
Query: 334 YKKDELLEAARSGNEEKLMALLT---PLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQ 390
AAR G+ + L L PL+V D LH+AA Y + QLL
Sbjct: 417 ------YWAARHGHVDTLKFLSENKCPLDVK----DKSGEMALHVAARYGHADVAQLLCS 466
Query: 391 HGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEV 450
G++ + +DK PLH A +G+Y V + L + G VN + TPL A+++ ++
Sbjct: 467 FGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDI 526
Query: 451 CSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLA 510
L HGAD + G A+ +A R + +K L+
Sbjct: 527 VECLAEHGADLNACDKDGHIALHLA---------------------VRRCQMEVIKTLLS 565
Query: 511 LEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH 570
Q + T LH A + L N++ NK TPLH+AA
Sbjct: 566 QGCFVDYQDRHGNTPLHVACKD---GNMPIVVALCEANCNLDISNKYGRTPLHLAANNGI 622
Query: 571 NDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
DV+ L GA + AL T G+TA A H LL D
Sbjct: 623 LDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLARLRKD 668
Score = 72.8 bits (177), Expect = 2e-12
Identities = 37/117 (31%), Positives = 65/117 (55%)
Query: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
N + + PL +AAG N+++ + L++ G+ ++ QDKGG ++ AA +GHVD
Sbjct: 369 NYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTL 428
Query: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
L + ++ DK LH AA+ G + LL + G++P ++++E +TPL A
Sbjct: 429 KFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCA 485
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 122 bits (306), Expect = 2e-27
Identities = 115/405 (28%), Positives = 186/405 (45%), Gaps = 29/405 (7%)
Query: 348 EEKLMALLTPLNVNCHASDGRKS---TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLV 404
EE+ + L L C D R TPL +AA + IV+ L+++GA+ + +D
Sbjct: 14 EEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWT 73
Query: 405 PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLV 464
L +A GH + E LLK G + D+ +T L A K R +V LLLSHGA+P++
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 465 NCH---------GKSAVDMAP---TPELRERLTYEFKGHSLLQAAREADLAKVKKTLALE 512
+ G+ D+ + + ++ L+ AAR+ L VK LA+
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 513 IINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHND 572
++ + TAL AV + Q + +L++ NVN +KD T L +A++ H +
Sbjct: 194 ADVDQEGANSMTALIVAVKGGY---TQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTE 250
Query: 573 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT----AA 628
+++ L G +N D G T L A GH++ R LL +D I T A
Sbjct: 251 IVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAV 310
Query: 629 QMGNEA-VQQIL--SESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHS 685
+ GN V+ IL + T I T D + L++A+K ++E V +L + ++ +
Sbjct: 311 EKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVV-ELLLDKGAKVSAVDKKGD 369
Query: 686 TPLHFAAGYNRVSVVEYLLHHGAD---VHAKDKGGLVPLHNACSY 727
TPLH A + E LL + D ++ +K G P + CS+
Sbjct: 370 TPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSH 414
Score = 117 bits (294), Expect = 6e-26
Identities = 99/321 (30%), Positives = 154/321 (47%), Gaps = 26/321 (8%)
Query: 646 RTSDVDYR-------LLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRV 697
+ DVD R L+ A++ G+LE VK+L + N N DL+ + T L A+ V
Sbjct: 27 KCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLD--NWTALISASKEGHV 84
Query: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
+VE LL G ++ +D GG L AC G +V ELL+ HGA+ +V L+ P+ A
Sbjct: 85 HIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWA 144
Query: 758 AAKGKYEICKLLLKHGADPTKKNRDGNTPL-------------DLVKEGDTDIQDLLRGD 804
A +G +I LLL++GA ++ G TPL L+ G Q+
Sbjct: 145 AGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSM 204
Query: 805 AALLDAAKKGCLARVQKLCTPE-NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADV 863
AL+ A K G V+++ N+N D G +T L +A+ + E+ + LL+ G V
Sbjct: 205 TALIVAVKGGYTQSVKEILKRNPNVNLTDKDG--NTALMIASKEGHTEIVQDLLDAGTYV 262
Query: 864 NAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLL 923
N D+ G L A GHV+I L++ ++ + T L+ A +KG + +L
Sbjct: 263 NIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDIL 322
Query: 924 AHGADPTMKNQEGQTPLDLAT 944
D + ++G+TPL AT
Sbjct: 323 QCNPDTEICTKDGETPLIKAT 343
Score = 115 bits (289), Expect = 2e-25
Identities = 111/370 (30%), Positives = 165/370 (44%), Gaps = 58/370 (15%)
Query: 627 AAQMGN-EAVQQILSESTPIRTSDVDY--RLLEASKAGDLETVKQLCS-SQNVNCRDLEG 682
AA+ GN E V++++ D+D L+ ASK G + V++L N+ RD+ G
Sbjct: 45 AAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGG 104
Query: 683 RHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGAS 742
T L +A R VVE LL HGA+ + P+ A GH ++ LL+++GA
Sbjct: 105 W--TALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAK 162
Query: 743 VNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKK----------------------- 779
VN +D + TPL AA KG E K LL GAD ++
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
Query: 780 ----------NRDGNTPLDLV-KEGDTDI-QDLL-----------RGDAALLDAAKKGCL 816
++DGNT L + KEG T+I QDLL GD L+ A + G +
Sbjct: 223 LKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHV 282
Query: 817 ARVQKLCTPENINCRDTQGR-NSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLH 875
V+ L + D +G+ N T L+ A N + +L+ D K G PL
Sbjct: 283 EIVRALL--QKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLI 340
Query: 876 NAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTM---K 932
A ++++ LL+ V+A DK TPLH A + +L LLL + D +
Sbjct: 341 KATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRP 400
Query: 933 NQEGQTPLDL 942
N+ G+TP ++
Sbjct: 401 NKAGETPYNI 410
Score = 105 bits (263), Expect = 2e-22
Identities = 124/467 (26%), Positives = 192/467 (41%), Gaps = 62/467 (13%)
Query: 186 LLEACRNGDVSRVKRLV-DAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
L+ A G++ VK L+ + AN N +D+ + L A+ G +VE LL+ G N+
Sbjct: 42 LMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA--LISASKEGHVHIVEELLKCGVNLEH 99
Query: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
RD GG L AC G +VV LLL GA+P+ ++ P+ AA +G D+ +LLQ+
Sbjct: 100 RDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQN 159
Query: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
GA N + +Y L+ AAR G+ E + LL + +
Sbjct: 160 GAKVN--------------------CSDKYGTTPLVWAARKGHLECVKHLLA-MGADVDQ 198
Query: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
T L +A + V+ +L+ +V+ DK G L A GH E+ + LL
Sbjct: 199 EGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDA 258
Query: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERL 484
G VN D T L A VE+ LL AD + K+A
Sbjct: 259 GTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTA------------- 305
Query: 485 TYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELL 544
L A + + V+ L + ET L + + + +V ELL
Sbjct: 306 --------LYWAVEKGNATMVRDILQCNPDTEICTKDGETPL---IKATKMRNIEVVELL 354
Query: 545 LRKGANVNEKNKDFMTPLHVAAERAHNDVMEVL---HKHGAKMNALDTLGQT-----ALH 596
L KGA V+ +K TPLH+A + E+L K G + + G+T H
Sbjct: 355 LDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNIDCSH 414
Query: 597 RAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSEST 643
+ ++ + R L +D ++ +++ A+ ILSE T
Sbjct: 415 QKSILTQIFGARHLSPTETDGDMLGYDLYSS------ALADILSEPT 455
Score = 99.8 bits (247), Expect = 2e-20
Identities = 105/395 (26%), Positives = 164/395 (41%), Gaps = 66/395 (16%)
Query: 437 TPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQA 496
TPL AA + +E+ L+ +GA+ L + +A L+ A
Sbjct: 40 TPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA---------------------LISA 78
Query: 497 AREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNK 556
++E + V++ L + + TAL A + R V ELLL GAN +
Sbjct: 79 SKEGHVHIVEELLKCGVNLEHRDMGGWTALMWAC---YKGRTDVVELLLSHGANPSVTGL 135
Query: 557 DFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSD 616
+ P+ AA R H D++ +L ++GAK+N D G T L AA GHL+ + LL+ G+D
Sbjct: 136 YSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195
Query: 617 PSIISLQGFTAAQMG-----NEAVQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQL 669
TA + ++V++IL + + +D D L+ ASK G E V+ L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 670 CSSQN-VNCRDLEGR-------------------------------HSTPLHFAAGYNRV 697
+ VN D G + T L++A
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNA 315
Query: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
++V +L D K G PL A + EV ELL+ GA V+ D TPLH A
Sbjct: 316 TMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Query: 758 AAKGKYEICKLLLKHGADPT---KKNRDGNTPLDL 789
++ +LLL++ D + N+ G TP ++
Sbjct: 376 IRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 91.7 bits (226), Expect = 4e-18
Identities = 82/274 (29%), Positives = 130/274 (47%), Gaps = 20/274 (7%)
Query: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
+ ++ LL DV +++ G PL A G+ E+ + L+++GA+ N+ DL +T L
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
Query: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLD-LVKEGDTDIQDLLRGDAA--------- 806
A+ +G I + LLK G + ++ G T L +G TD+ +LL A
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYS 137
Query: 807 ---LLDAAKKGCLARVQKLC-TPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGAD 862
++ AA +G V L +NC D G +TPL AA +LE ++LL GAD
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYG--TTPLVWAARKGHLECVKHLLAMGAD 195
Query: 863 VNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALL 922
V+ + + L A G+ ++K N VN TDK T L A+++G T++ L
Sbjct: 196 VDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDL 255
Query: 923 LAHGADPTMKNQEGQTPLDLAT----ADDIRALL 952
L G + ++ G T L A + +RALL
Sbjct: 256 LDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALL 289
Score = 40.0 bits (92), Expect = 0.015
Identities = 28/92 (30%), Positives = 45/92 (48%)
Query: 849 NLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLH 908
N+ + LLE DV+ +++ G PL AA G+++I LIK N D +T L
Sbjct: 17 NIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALI 76
Query: 909 EAAQKGRTQLCALLLAHGADPTMKNQEGQTPL 940
A+++G + LL G + ++ G T L
Sbjct: 77 SASKEGHVHIVEELLKCGVNLEHRDMGGWTAL 108
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,808,277
Number of Sequences: 37866
Number of extensions: 3004744
Number of successful extensions: 66079
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1024
Number of HSP's successfully gapped in prelim test: 1532
Number of HSP's that attempted gapping in prelim test: 25024
Number of HSP's gapped (non-prelim): 21299
length of query: 1327
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1213
effective length of database: 13,930,794
effective search space: 16898053122
effective search space used: 16898053122
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.