Search of human proteins with 84490388

Search of human proteins with 84490388

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|84490388 R-spondin1 [Homo sapiens]
         (263 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|84490388 R-spondin1 [Homo sapiens]                                 562   e-161
gi|18490982 R-spondin 3 [Homo sapiens]                                252   2e-67
gi|222446611 R-spondin family, member 2 [Homo sapiens]                208   3e-54
gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo...   176   2e-44
gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo...   127   8e-30
gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo ...    67   2e-11
gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo ...    67   2e-11
gi|239755070 PREDICTED: similar to proprotein convertase subtili...    66   4e-11
gi|20336246 proprotein convertase subtilisin/kexin type 5 prepro...    60   3e-09
gi|20336184 paired basic amino acid cleaving system 4 isoform h ...    59   4e-09
gi|20336182 paired basic amino acid cleaving system 4 isoform g ...    59   4e-09
gi|4505577 paired basic amino acid cleaving system 4 isoform a p...    59   4e-09
gi|20336180 paired basic amino acid cleaving system 4 isoform b ...    59   4e-09
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]    51   1e-06
gi|122937257 thrombospondin, type I, domain containing 7B [Homo ...    50   2e-06
gi|108773804 Fraser syndrome 1 [Homo sapiens]                          49   3e-06
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ...    48   8e-06
gi|14790170 tumor necrosis factor receptor superfamily, member 6...    43   2e-04
gi|4507585 tumor necrosis factor receptor superfamily, member 6b...    43   2e-04
gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens]    42   5e-04
gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens]      42   5e-04
gi|134031945 SCO-spondin [Homo sapiens]                                42   5e-04
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]      39   0.004
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s...    39   0.005
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]    38   0.008
gi|192449445 cartilage intermediate layer protein [Homo sapiens]       37   0.013
gi|31657140 insulin receptor-related receptor precursor [Homo sa...    37   0.018
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...    37   0.018
gi|4505737 complement factor properdin precursor [Homo sapiens]        37   0.023
gi|148743793 osteoprotegerin precursor [Homo sapiens]                  37   0.023

>gi|84490388 R-spondin1 [Homo sapiens]
          Length = 263

 Score =  562 bits (1449), Expect = e-161
 Identities = 263/263 (100%), Positives = 263/263 (100%)

Query: 1   MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL 60
           MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL
Sbjct: 1   MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL 60

Query: 61  FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 120
           FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL
Sbjct: 61  FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 120

Query: 121 HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL 180
           HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL
Sbjct: 121 HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL 180

Query: 181 HAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR 240
           HAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR
Sbjct: 181 HAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR 240

Query: 241 RRKGQQQQQQQGTVGPLTSAGPA 263
           RRKGQQQQQQQGTVGPLTSAGPA
Sbjct: 241 RRKGQQQQQQQGTVGPLTSAGPA 263


>gi|18490982 R-spondin 3 [Homo sapiens]
          Length = 272

 Score =  252 bits (644), Expect = 2e-67
 Identities = 116/252 (46%), Positives = 159/252 (63%), Gaps = 15/252 (5%)

Query: 10  LVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDI 69
           ++L++     S    +G+RQRR+    SQ C  GC  CS+ NGCL C P+LF  LER  +
Sbjct: 11  IILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGM 70

Query: 70  RQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPAC 129
           +Q+GVCL SCP GY+  R PD+NKC KCK + C+ CF+ NFCTKCK G YLH G+C   C
Sbjct: 71  KQIGVCLSSCPSGYYGTRYPDINKCTKCKAD-CDTCFNKNFCTKCKSGFYLHLGKCLDNC 129

Query: 130 PEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAA 189
           PEG  A N TMEC S   CE+SEW+PW PC+KK + CGF+RG+E R R ++  P      
Sbjct: 130 PEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNL 189

Query: 190 CSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLARKESKEAGAGSR--------- 240
           C  T ETR+CTV+R  C +G++ +KG + +R+  N+     ESKEA   S+         
Sbjct: 190 CPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKG----ESKEAIPDSKSLESSKEIP 245

Query: 241 -RRKGQQQQQQQ 251
            +R+ +QQQ+++
Sbjct: 246 EQRENKQQQKKR 257


>gi|222446611 R-spondin family, member 2 [Homo sapiens]
          Length = 243

 Score =  208 bits (530), Expect = 3e-54
 Identities = 93/213 (43%), Positives = 129/213 (60%), Gaps = 3/213 (1%)

Query: 22  RGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPP 81
           +G + +R +R S   +  C KGC  CS+ NGC +C  KLF  L R  +RQ G CL SCP 
Sbjct: 22  QGNRWRRSKRASYVSNPIC-KGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPS 80

Query: 82  GYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTME 141
           GY+  R PDMN+C +C+IE+C++CFS +FCTKCK G YLH+GRC+  CP+G +    TME
Sbjct: 81  GYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETME 140

Query: 142 CSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTV 201
           C     CE+  WS WG CS+  + CGF+ G E RTR+++  PV D   C    E+RRC +
Sbjct: 141 CVE--GCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPVKDTILCPTIAESRRCKM 198

Query: 202 RRVPCPEGQKRRKGGQGRRENANRNLARKESKE 234
               CP G++  K  + R +   R L  +  ++
Sbjct: 199 TMRHCPGGKRTPKAKEKRNKKKKRKLIERAQEQ 231


>gi|83722284 R-spondin family, member 4 isoform 1 precursor [Homo
           sapiens]
          Length = 234

 Score =  176 bits (445), Expect = 2e-44
 Identities = 89/232 (38%), Positives = 124/232 (53%), Gaps = 12/232 (5%)

Query: 1   MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL 60
           MR  LC++ LV     +   +R     R++++       C  GC +CSE NGC  C  +L
Sbjct: 1   MRAPLCLLLLVAHAVDMLALNR-----RKKQVGTGLGGNCT-GCIICSEENGCSTCQQRL 54

Query: 61  FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 120
           F+ + R  IRQ G CL  CPPGYF  R  ++N+C KC    CE+CFS +FC +CK   YL
Sbjct: 55  FLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYL 113

Query: 121 HKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVL 180
           +KG+C P CP G+ A   T EC    +CE+  W  W PC+   + CG   G E R R   
Sbjct: 114 YKGKCLPTCPPGTLAHQNTRECQ--GECELGPWGGWSPCTHNGKTCGSAWGLESRVREAG 171

Query: 181 HAPVGDHAACSDTKETRRCTVRRVPCP--EGQKRRKGGQGRRENANRNLARK 230
            A   + A C    E+R+C ++R PCP      ++KG + RR   +R L R+
Sbjct: 172 RAGHEEAATCQVLSESRKCPIQR-PCPGERSPGQKKGRKDRRPRKDRKLDRR 222


>gi|90970328 R-spondin family, member 4 isoform 2 precursor [Homo
           sapiens]
          Length = 172

 Score =  127 bits (320), Expect = 8e-30
 Identities = 63/149 (42%), Positives = 84/149 (56%), Gaps = 9/149 (6%)

Query: 1   MRLGLCVVALVLSWTHLTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNGCLKCSPKL 60
           MR  LC++ LV     +   +R     R++++       C  GC +CSE NGC  C  +L
Sbjct: 1   MRAPLCLLLLVAHAVDMLALNR-----RKKQVGTGLGGNCT-GCIICSEENGCSTCQQRL 54

Query: 61  FILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYL 120
           F+ + R  IRQ G CL  CPPGYF  R  ++N+C KC    CE+CFS +FC +CK   YL
Sbjct: 55  FLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGAT-CESCFSQDFCIRCKRQFYL 113

Query: 121 HKGRCYPACPEGSSAANGTMECS--SPAQ 147
           +KG+C P CP G+ A   T EC   SP Q
Sbjct: 114 YKGKCLPTCPPGTLAHQNTRECQERSPGQ 142


>gi|239749596 PREDICTED: hypothetical protein XP_002347099 [Homo
           sapiens]
          Length = 853

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 53/179 (29%), Positives = 69/179 (38%), Gaps = 39/179 (21%)

Query: 38  QACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIK 96
           Q C   C+ C+     C  C    ++L +         C+ SCP G + +       C  
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQ--------ACVSSCPQGTWPSVRS--GSCEN 223

Query: 97  CKIEHCEACFSHNFCTKCK----EGLYLHKGRCYPACPEGSSAANGTME-CSSPAQCEMS 151
           C  E C  C   + C KC+      L+LH+GRCY  CPEGS A +G  E CSSP +    
Sbjct: 224 CT-EACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCR---- 278

Query: 152 EWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRV--PCPE 208
                  C      C    G       VLH     H  C +    R   V+ V   CPE
Sbjct: 279 ------TCEGNATNCHSCEGG-----HVLH-----HGVCQENCPERHVAVKGVCKHCPE 321



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 14/93 (15%)

Query: 38  QACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
           +AC   C  C + NGC  C    F+L         G C+  C PG++   + +M +C  C
Sbjct: 76  KACDSNCGSCDQ-NGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESC 124

Query: 98  KIEHCEACFS--HNFCTKCKEGLYLHKGRCYPA 128
               CE C    H+ C+ C+EGL L +G C  A
Sbjct: 125 H-RACETCTGPGHDECSSCQEGLQLLRGMCVHA 156



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 24/130 (18%)

Query: 38  QACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIK 96
           + C+  C  C      C  C        E   +   GVC  +CP  +   +      C  
Sbjct: 271 ERCSSPCRTCEGNATNCHSC--------EGGHVLHHGVCQENCPERHVAVKGV----CKH 318

Query: 97  CKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAAN--------GTMECSSPA-- 146
           C  E C+ C     C +C    +LH   C+ +CP G  A +          +ECS P   
Sbjct: 319 CP-EMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKAD 377

Query: 147 QCEMSEWSPW 156
            CE+   S W
Sbjct: 378 DCELCLESSW 387



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 42/147 (28%), Positives = 62/147 (42%), Gaps = 33/147 (22%)

Query: 36  GSQACAKGCELCSEVNGCLKCS-PKLF---ILLERNDIRQVGVCLPSCPPG-YFDARNPD 90
           G  A ++ C  C +   CL+CS PK     + LE + +   G+CL  CP G Y++    +
Sbjct: 353 GFYADSRHCVPCHK--DCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKE 410

Query: 91  MNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQ--- 147
              C K     C  C S   CT C++GL ++        P GS  AN   E  SP++   
Sbjct: 411 CRDCHKS----CLTCSSSGTCTTCQKGLIMN--------PRGSCMAN---EKCSPSEYWD 455

Query: 148 --------CEMSEWSPWGPCSKKQQLC 166
                   C +  +   GP   + Q C
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTC 482



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 38/145 (26%), Positives = 51/145 (35%), Gaps = 23/145 (15%)

Query: 17  LTISSRGIKGKRQRRISAEGSQACAKGCELCS-------EVNGCLKCSPKLFILL----- 64
           LT SS G     Q+ +      +C    E CS       +  GC  C  K F  +     
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMAN-EKCSPSEYWDEDAPGCKPCHVKCFHCMGPAED 477

Query: 65  -----ERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNF--CTKCKEG 117
                  N +     C+  CP GY+   + D N+C  C    C  C   +   C  C+ G
Sbjct: 478 QCQTCPMNSLLLNTTCVKDCPEGYY--ADEDSNRCAHCH-SSCRTCEGRHSRQCHSCRPG 534

Query: 118 LYLHKGRCYPACPEGSSAANGTMEC 142
            +     C   C EG  A N T  C
Sbjct: 535 WFQLGKECLLQCREGYYADNSTGRC 559



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 32/135 (23%), Positives = 48/135 (35%), Gaps = 20/135 (14%)

Query: 17  LTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNG-----CLKCSPKLFILLERNDIRQ 71
           L +++  +K   +   + E S  CA     C    G     C  C P  F L +      
Sbjct: 487 LLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKE----- 541

Query: 72  VGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHN--FCTKCKEGLYL--HKGRCYP 127
              CL  C  GY+   +    +C +C    C+ C       C  C    +L   KG C+ 
Sbjct: 542 ---CLLQCREGYY--ADNSTGRCERCN-RSCKGCQGPRPTDCLSCDRFFFLLRSKGECHR 595

Query: 128 ACPEGSSAANGTMEC 142
           +CP+       T  C
Sbjct: 596 SCPDHYYVEQSTQTC 610



 Score = 35.0 bits (79), Expect = 0.067
 Identities = 27/100 (27%), Positives = 38/100 (38%), Gaps = 11/100 (11%)

Query: 75  CLPSCPPGYFDARNPDMNKCIKCKI--EHCEACFSHNFCTKCKEGLYLHKGRCYPACPEG 132
           C  +CP   +       ++ ++CK    +C +C   N C  C+EG +L  G C   C  G
Sbjct: 60  CYKTCPEKTY-------SEAVECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPG 111

Query: 133 SSAANGTMECSS-PAQCEMSEWSPWGPCSKKQQLCGFRRG 171
                   EC S    CE         CS  Q+     RG
Sbjct: 112 FYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRG 151


>gi|239743863 PREDICTED: hypothetical protein XP_002342982 [Homo
           sapiens]
          Length = 853

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 53/179 (29%), Positives = 69/179 (38%), Gaps = 39/179 (21%)

Query: 38  QACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIK 96
           Q C   C+ C+     C  C    ++L +         C+ SCP G + +       C  
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQ--------ACVSSCPQGTWPSVRS--GSCEN 223

Query: 97  CKIEHCEACFSHNFCTKCK----EGLYLHKGRCYPACPEGSSAANGTME-CSSPAQCEMS 151
           C  E C  C   + C KC+      L+LH+GRCY  CPEGS A +G  E CSSP +    
Sbjct: 224 CT-EACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCR---- 278

Query: 152 EWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRV--PCPE 208
                  C      C    G       VLH     H  C +    R   V+ V   CPE
Sbjct: 279 ------TCEGNATNCHSCEGG-----HVLH-----HGVCQENCPERHVAVKGVCKHCPE 321



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 14/93 (15%)

Query: 38  QACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
           +AC   C  C + NGC  C    F+L         G C+  C PG++   + +M +C  C
Sbjct: 76  KACDSNCGSCDQ-NGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESC 124

Query: 98  KIEHCEACFS--HNFCTKCKEGLYLHKGRCYPA 128
               CE C    H+ C+ C+EGL L +G C  A
Sbjct: 125 H-RACETCTGPGHDECSSCQEGLQLLRGMCVHA 156



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 33/130 (25%), Positives = 47/130 (36%), Gaps = 24/130 (18%)

Query: 38  QACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIK 96
           + C+  C  C      C  C        E   +   GVC  +CP  +   +      C  
Sbjct: 271 ERCSSPCRTCEGNATNCHSC--------EGGHVLHHGVCQENCPERHVAVKGV----CKH 318

Query: 97  CKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAAN--------GTMECSSPA-- 146
           C  E C+ C     C +C    +LH   C+ +CP G  A +          +ECS P   
Sbjct: 319 CP-EMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKAD 377

Query: 147 QCEMSEWSPW 156
            CE+   S W
Sbjct: 378 DCELCLESSW 387



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 42/147 (28%), Positives = 62/147 (42%), Gaps = 33/147 (22%)

Query: 36  GSQACAKGCELCSEVNGCLKCS-PKLF---ILLERNDIRQVGVCLPSCPPG-YFDARNPD 90
           G  A ++ C  C +   CL+CS PK     + LE + +   G+CL  CP G Y++    +
Sbjct: 353 GFYADSRHCVPCHK--DCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYEKETKE 410

Query: 91  MNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQ--- 147
              C K     C  C S   CT C++GL ++        P GS  AN   E  SP++   
Sbjct: 411 CRDCHKS----CLTCSSSGTCTTCQKGLIMN--------PRGSCMAN---EKCSPSEYWD 455

Query: 148 --------CEMSEWSPWGPCSKKQQLC 166
                   C +  +   GP   + Q C
Sbjct: 456 EDAPGCKPCHVKCFHCMGPAEDQCQTC 482



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 38/145 (26%), Positives = 51/145 (35%), Gaps = 23/145 (15%)

Query: 17  LTISSRGIKGKRQRRISAEGSQACAKGCELCS-------EVNGCLKCSPKLFILL----- 64
           LT SS G     Q+ +      +C    E CS       +  GC  C  K F  +     
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMAN-EKCSPSEYWDEDAPGCKPCHVKCFHCMGPAED 477

Query: 65  -----ERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNF--CTKCKEG 117
                  N +     C+  CP GY+   + D N+C  C    C  C   +   C  C+ G
Sbjct: 478 QCQTCPMNSLLLNTTCVKDCPEGYY--ADEDSNRCAHCH-SSCRTCEGRHSRQCHSCRPG 534

Query: 118 LYLHKGRCYPACPEGSSAANGTMEC 142
            +     C   C EG  A N T  C
Sbjct: 535 WFQLGKECLLQCREGYYADNSTGRC 559



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 32/135 (23%), Positives = 48/135 (35%), Gaps = 20/135 (14%)

Query: 17  LTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNG-----CLKCSPKLFILLERNDIRQ 71
           L +++  +K   +   + E S  CA     C    G     C  C P  F L +      
Sbjct: 487 LLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKE----- 541

Query: 72  VGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHN--FCTKCKEGLYL--HKGRCYP 127
              CL  C  GY+   +    +C +C    C+ C       C  C    +L   KG C+ 
Sbjct: 542 ---CLLQCREGYY--ADNSTGRCERCN-RSCKGCQGPRPTDCLSCDRFFFLLRSKGECHR 595

Query: 128 ACPEGSSAANGTMEC 142
           +CP+       T  C
Sbjct: 596 SCPDHYYVEQSTQTC 610



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 27/100 (27%), Positives = 36/100 (36%), Gaps = 11/100 (11%)

Query: 75  CLPSCPPGYFDARNPDMNKCIKCKI--EHCEACFSHNFCTKCKEGLYLHKGRCYPACPEG 132
           C  +CP   +          ++CK    +C +C   N C  C+EG +L  G C   C  G
Sbjct: 60  CYKTCPEKTYSEE-------VECKACDSNCGSC-DQNGCYWCEEGFFLLGGSCVRKCGPG 111

Query: 133 SSAANGTMECSS-PAQCEMSEWSPWGPCSKKQQLCGFRRG 171
                   EC S    CE         CS  Q+     RG
Sbjct: 112 FYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRG 151


>gi|239755070 PREDICTED: similar to proprotein convertase
           subtilisin/kexin type 5 [Homo sapiens]
          Length = 853

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 41/119 (34%), Positives = 55/119 (46%), Gaps = 18/119 (15%)

Query: 38  QACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIK 96
           Q C   C+ C+     C  C    ++L +         C+ SCP G + +       C  
Sbjct: 174 QPCHSSCKTCNGSATLCTSCPKGAYLLAQ--------ACVSSCPQGTWPSVRS--GSCEN 223

Query: 97  CKIEHCEACFSHNFCTKCK----EGLYLHKGRCYPACPEGSSAANGTME-CSSPAQ-CE 149
           C  E C  C   + C KC+      L+LH+GRCY  CPEGS A +G  E CSSP + CE
Sbjct: 224 CT-EACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCE 281



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 31/93 (33%), Positives = 44/93 (47%), Gaps = 14/93 (15%)

Query: 38  QACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
           +AC   C  C + NGC  C    F+L         G C+  C PG++   + +M +C  C
Sbjct: 76  KACDSNCSSCDQ-NGCYWCEEGFFLL--------GGSCVRKCGPGFYG--DQEMGECESC 124

Query: 98  KIEHCEACFS--HNFCTKCKEGLYLHKGRCYPA 128
               CE C    H+ C+ C+EGL L +G C  A
Sbjct: 125 H-RACETCTGPGHDECSSCQEGLQLLRGMCVHA 156



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 33/130 (25%), Positives = 46/130 (35%), Gaps = 24/130 (18%)

Query: 38  QACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIK 96
           + C+  C  C      C  C        E   +   GVC  +CP  +          C  
Sbjct: 271 ERCSSPCRTCEGNATNCHSC--------EGGHVLHHGVCQENCPERHVAVEGV----CKH 318

Query: 97  CKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAAN--------GTMECSSPA-- 146
           C  E C+ C     C +C    +LH   C+ +CP G  A +          +ECS P   
Sbjct: 319 CP-EMCQDCIHEKTCKECMPEFFLHDDMCHQSCPRGFYADSHHCVPCHKDCLECSGPKAD 377

Query: 147 QCEMSEWSPW 156
            CE+   S W
Sbjct: 378 DCELCLESSW 387



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 43/152 (28%), Positives = 64/152 (42%), Gaps = 40/152 (26%)

Query: 38  QACAKG-------CELCSEVNGCLKCS-PKLF---ILLERNDIRQVGVCLPSCPPG-YFD 85
           Q+C +G       C  C +   CL+CS PK     + LE + +   G+CL  CP G Y++
Sbjct: 348 QSCPRGFYADSHHCVPCHK--DCLECSGPKADDCELCLESSWVLYDGLCLEECPAGTYYE 405

Query: 86  ARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSP 145
            +  +   C K     C  C S   CT C++GL ++        P GS  AN   E  SP
Sbjct: 406 KQTKECRDCHKS----CLTCSSSGTCTTCQKGLIMN--------PRGSCMAN---EKCSP 450

Query: 146 AQ-----------CEMSEWSPWGPCSKKQQLC 166
           ++           C +  +   GP   + Q C
Sbjct: 451 SEYWDEDAPGCKPCHVKCFHCMGPAEDQCQTC 482



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 38/145 (26%), Positives = 51/145 (35%), Gaps = 23/145 (15%)

Query: 17  LTISSRGIKGKRQRRISAEGSQACAKGCELCS-------EVNGCLKCSPKLFILL----- 64
           LT SS G     Q+ +      +C    E CS       +  GC  C  K F  +     
Sbjct: 419 LTCSSSGTCTTCQKGLIMNPRGSCMAN-EKCSPSEYWDEDAPGCKPCHVKCFHCMGPAED 477

Query: 65  -----ERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNF--CTKCKEG 117
                  N +     C+  CP GY+   + D N+C  C    C  C   +   C  C+ G
Sbjct: 478 QCQTCPMNSLLLNTTCVKDCPEGYY--ADEDSNRCAHCH-SSCRTCEGRHSRQCHSCRPG 534

Query: 118 LYLHKGRCYPACPEGSSAANGTMEC 142
            +     C   C EG  A N T  C
Sbjct: 535 WFQLGKECLLQCREGYYADNSTGRC 559



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 27/100 (27%), Positives = 38/100 (38%), Gaps = 11/100 (11%)

Query: 75  CLPSCPPGYFDARNPDMNKCIKCKI--EHCEACFSHNFCTKCKEGLYLHKGRCYPACPEG 132
           C  +CP   +       ++ ++CK    +C +C   N C  C+EG +L  G C   C  G
Sbjct: 60  CYKTCPEKTY-------SEAVECKACDSNCSSC-DQNGCYWCEEGFFLLGGSCVRKCGPG 111

Query: 133 SSAANGTMECSS-PAQCEMSEWSPWGPCSKKQQLCGFRRG 171
                   EC S    CE         CS  Q+     RG
Sbjct: 112 FYGDQEMGECESCHRACETCTGPGHDECSSCQEGLQLLRG 151



 Score = 35.8 bits (81), Expect = 0.039
 Identities = 32/135 (23%), Positives = 48/135 (35%), Gaps = 20/135 (14%)

Query: 17  LTISSRGIKGKRQRRISAEGSQACAKGCELCSEVNG-----CLKCSPKLFILLERNDIRQ 71
           L +++  +K   +   + E S  CA     C    G     C  C P  F L +      
Sbjct: 487 LLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKE----- 541

Query: 72  VGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHN--FCTKCKEGLYL--HKGRCYP 127
              CL  C  GY+   +    +C +C    C+ C       C  C    +L   KG C+ 
Sbjct: 542 ---CLLQCREGYY--ADNSTGRCERCN-RSCKGCQGPRPTDCLSCDRFFFLLRSKGECHR 595

Query: 128 ACPEGSSAANGTMEC 142
           +CP+       T  C
Sbjct: 596 SCPDHYYVEQSTQTC 610


>gi|20336246 proprotein convertase subtilisin/kexin type 5
           preproprotein [Homo sapiens]
          Length = 913

 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 32/95 (33%), Positives = 47/95 (49%), Gaps = 11/95 (11%)

Query: 40  CAKGCELCSEVNG--CLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
           CA  CE C   +G  C+ C    F+  E N       C+  CP G +  ++   N C KC
Sbjct: 689 CAPNCESCFGSHGDQCMSCKYGYFLNEETNS------CVTHCPDGSY--QDTKKNLCRKC 740

Query: 98  KIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEG 132
             E+C+ C   + CT+C++GL L   RC  +C +G
Sbjct: 741 S-ENCKTCTEFHNCTECRDGLSLQGSRCSVSCEDG 774



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 41/113 (36%), Positives = 58/113 (51%), Gaps = 27/113 (23%)

Query: 36  GSQACAKGCEL-CSEV----------NGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYF 84
           G++  A  C+  CSEV          N CL    KL     +N+ R   +C+ SCPPG++
Sbjct: 628 GTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKL-----KNNTR---ICVSSCPPGHY 679

Query: 85  DARNPDMNKCIKCKIEHCEACF-SH-NFCTKCKEGLYLHK--GRCYPACPEGS 133
            A   D  +C KC   +CE+CF SH + C  CK G +L++    C   CP+GS
Sbjct: 680 HA---DKKRCRKC-APNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGS 728



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 36/134 (26%), Positives = 54/134 (40%), Gaps = 24/134 (17%)

Query: 40  CAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPG-YFDARNPDMNKCIKCK 98
           C++ C+ C+E + C +C   L +   R        C  SC  G YF+ ++     C  C 
Sbjct: 740 CSENCKTCTEFHNCTECRDGLSLQGSR--------CSVSCEDGRYFNGQD-----CQPCH 786

Query: 99  IEHCEACFSHNF--CTKCKEGLYLHKGRCYPACPEG----SSAANGTMECSSPAQCEMSE 152
              C  C       C  C EG ++  GRC  +C        S+ NG   C    +C++S 
Sbjct: 787 -RFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCK---KCDISC 842

Query: 153 WSPWGPCSKKQQLC 166
            +  GP  K    C
Sbjct: 843 LTCNGPGFKNCTSC 856



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 38/145 (26%), Positives = 54/145 (37%), Gaps = 31/145 (21%)

Query: 30  RRISAEGSQACAKGCELCSEV--NGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDAR 87
           R  + +  Q C + C  C+    +GC+ C+   F+        + G C+ SC   Y+   
Sbjct: 775 RYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFM--------EDGRCVQSCSISYYFDH 826

Query: 88  NPD--MNKCIKCKIEHCEACFSHNF--CTKCKEGLYLHKGRCYPACPEGSSAANGTMECS 143
           + +     C KC I  C  C    F  CT C  G  L  G     C  G+   + T E  
Sbjct: 827 SSENGYKSCKKCDIS-CLTCNGPGFKNCTSCPSGYLLDLG----MCQMGAICKDATEE-- 879

Query: 144 SPAQCEMSEWSPWGPCS--KKQQLC 166
                    W+  G C   KK  LC
Sbjct: 880 --------SWAEGGFCMLVKKNNLC 896


>gi|20336184 paired basic amino acid cleaving system 4 isoform h
           preproprotein [Homo sapiens]
          Length = 962

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 48/113 (42%), Gaps = 12/113 (10%)

Query: 33  SAEGSQACAKGCELCSE--VNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPD 90
           +A   + C KGCE CS      CL C    +   E N       C+  CP G++   +  
Sbjct: 729 AARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMN------TCVTLCPAGFY--ADES 780

Query: 91  MNKCIKCKIEHCEACFSH-NFCTKCKEGLYLHKGRCYPACPEGSSAANGTMEC 142
              C+KC    C+ C      CT CKEG  L +G C P C  G+   +  + C
Sbjct: 781 QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC 832



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 16/105 (15%)

Query: 40  CAKGCELCSEVNGCLKCSPKLFILLERNDIRQV---------GVCLPSCPPG-YFDARNP 89
           C  G         CLKC P     ++  +   V         G C+P C PG YFD+   
Sbjct: 771 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS--- 827

Query: 90  DMNKCIKCKIEHCEACFS--HNFCTKCKEGLYLHKGRCYPACPEG 132
           ++ +C +C    C  C       C  C +  + H  +C PAC EG
Sbjct: 828 ELIRCGECH-HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871


>gi|20336182 paired basic amino acid cleaving system 4 isoform g
           preproprotein [Homo sapiens]
          Length = 975

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 48/113 (42%), Gaps = 12/113 (10%)

Query: 33  SAEGSQACAKGCELCSE--VNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPD 90
           +A   + C KGCE CS      CL C    +   E N       C+  CP G++   +  
Sbjct: 742 AARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMN------TCVTLCPAGFY--ADES 793

Query: 91  MNKCIKCKIEHCEACFSH-NFCTKCKEGLYLHKGRCYPACPEGSSAANGTMEC 142
              C+KC    C+ C      CT CKEG  L +G C P C  G+   +  + C
Sbjct: 794 QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC 845



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 16/105 (15%)

Query: 40  CAKGCELCSEVNGCLKCSPKLFILLERNDIRQV---------GVCLPSCPPG-YFDARNP 89
           C  G         CLKC P     ++  +   V         G C+P C PG YFD+   
Sbjct: 784 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS--- 840

Query: 90  DMNKCIKCKIEHCEACFS--HNFCTKCKEGLYLHKGRCYPACPEG 132
           ++ +C +C    C  C       C  C +  + H  +C PAC EG
Sbjct: 841 ELIRCGECH-HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884


>gi|4505577 paired basic amino acid cleaving system 4 isoform a
           preproprotein [Homo sapiens]
          Length = 969

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 48/113 (42%), Gaps = 12/113 (10%)

Query: 33  SAEGSQACAKGCELCSE--VNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPD 90
           +A   + C KGCE CS      CL C    +   E N       C+  CP G++   +  
Sbjct: 742 AARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMN------TCVTLCPAGFY--ADES 793

Query: 91  MNKCIKCKIEHCEACFSH-NFCTKCKEGLYLHKGRCYPACPEGSSAANGTMEC 142
              C+KC    C+ C      CT CKEG  L +G C P C  G+   +  + C
Sbjct: 794 QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC 845



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 16/105 (15%)

Query: 40  CAKGCELCSEVNGCLKCSPKLFILLERNDIRQV---------GVCLPSCPPG-YFDARNP 89
           C  G         CLKC P     ++  +   V         G C+P C PG YFD+   
Sbjct: 784 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS--- 840

Query: 90  DMNKCIKCKIEHCEACFS--HNFCTKCKEGLYLHKGRCYPACPEG 132
           ++ +C +C    C  C       C  C +  + H  +C PAC EG
Sbjct: 841 ELIRCGECH-HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 884


>gi|20336180 paired basic amino acid cleaving system 4 isoform b
           preproprotein [Homo sapiens]
          Length = 956

 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 35/113 (30%), Positives = 48/113 (42%), Gaps = 12/113 (10%)

Query: 33  SAEGSQACAKGCELCSE--VNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPD 90
           +A   + C KGCE CS      CL C    +   E N       C+  CP G++   +  
Sbjct: 729 AARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMN------TCVTLCPAGFY--ADES 780

Query: 91  MNKCIKCKIEHCEACFSH-NFCTKCKEGLYLHKGRCYPACPEGSSAANGTMEC 142
              C+KC    C+ C      CT CKEG  L +G C P C  G+   +  + C
Sbjct: 781 QKNCLKCH-PSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDSELIRC 832



 Score = 46.6 bits (109), Expect = 2e-05
 Identities = 30/105 (28%), Positives = 42/105 (40%), Gaps = 16/105 (15%)

Query: 40  CAKGCELCSEVNGCLKCSPKLFILLERNDIRQV---------GVCLPSCPPG-YFDARNP 89
           C  G         CLKC P     ++  +   V         G C+P C PG YFD+   
Sbjct: 771 CPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS--- 827

Query: 90  DMNKCIKCKIEHCEACFS--HNFCTKCKEGLYLHKGRCYPACPEG 132
           ++ +C +C    C  C       C  C +  + H  +C PAC EG
Sbjct: 828 ELIRCGECH-HTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEG 871


>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
          Length = 807

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 54/265 (20%), Positives = 92/265 (34%), Gaps = 36/265 (13%)

Query: 6   CVVALVLSWTHLTISSRGIKGKRQRRISA--EGSQACAKGCELCSEVNGCLKCSPKLFIL 63
           C ++  ++W+  +IS       R+R +    E    C    E   +     +CSP   ++
Sbjct: 502 CTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEECSPSSCLM 561

Query: 64  LERNDIRQVGVCLPSCPPGYFDAR-----NPDMNKCIKCKIEHCEACFSHNFCT-KCKEG 117
            E  +  +   C  +C  G          NP      K +    E C      T  C   
Sbjct: 562 TEWGEWDE---CSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLS 618

Query: 118 LYLHKGRCYPACPEGSSAANGTM-------ECSS-------------PAQCEMSEWSPWG 157
            +     C   C +G       +       +C+              P  CE++EWS W 
Sbjct: 619 PWSEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWS 678

Query: 158 PCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQ 217
            C+K    CG  +G   RTR +   P    A C +T + ++C +R+       ++ +  +
Sbjct: 679 ECNKS---CG--KGHVIRTRMIQMEPQFGGAPCPETVQRKKCRIRKCLRNPSIQKLRWRE 733

Query: 218 GRRENANRNLARKESKEAGAGSRRR 242
            R    +  L  +   E   G R R
Sbjct: 734 ARESRRSEQLKEESEGEQFPGCRMR 758



 Score = 34.7 bits (78), Expect = 0.087
 Identities = 22/60 (36%), Positives = 26/60 (43%), Gaps = 8/60 (13%)

Query: 148 CEMSEWSPWGPCSKKQQLCGFRRGSEERTRRV-LHAPVGDHAACSDTKETRRCTVRRVPC 206
           C M  W+ W  C+K   LCG   G +ER   V          +C D KE R C V   PC
Sbjct: 755 CRMRPWTAWSECTK---LCG--GGIQERYMTVKKRFKSSQFTSCKDKKEIRACNVH--PC 807



 Score = 34.3 bits (77), Expect = 0.11
 Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 5/59 (8%)

Query: 141 ECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRC 199
           E  +P  C  S WSPW  CS     C   +G   R +R+L A +     C DT++ + C
Sbjct: 436 EDDTPETCIYSNWSPWSACS--SSTCD--KGKRMR-QRMLKAQLDLSVPCPDTQDFQPC 489


>gi|122937257 thrombospondin, type I, domain containing 7B [Homo
           sapiens]
          Length = 1577

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 22/60 (36%), Positives = 27/60 (45%)

Query: 142 CSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTV 201
           C  P  CE S+WS W PCSK  +      G   R+R V H  +G    C +  E   C V
Sbjct: 300 CIMPKDCETSQWSSWSPCSKTCRSGSLLPGFRSRSRNVKHMAIGGGKECPELLEKEACIV 359



 Score = 40.8 bits (94), Expect = 0.001
 Identities = 22/67 (32%), Positives = 33/67 (49%), Gaps = 6/67 (8%)

Query: 145 PAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRV 204
           P  C +SE+ PW  CSK     G  +  + RTR V+  P+     C +  E+R C    +
Sbjct: 146 PRDCVVSEFLPWSNCSK-----GCGKKLQHRTRAVIAPPLFGGLQCPNLTESRACDA-PI 199

Query: 205 PCPEGQK 211
            CP G++
Sbjct: 200 SCPLGEE 206



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 28/103 (27%), Positives = 38/103 (36%), Gaps = 14/103 (13%)

Query: 113  KCKEGLYLHKGRCY-----PACPEGSSAANGTME---CSSPAQCEMSEWSPWGPCSKKQQ 164
            +C EGL      C      P  P   S++    E      P  C++S+WS WG CS    
Sbjct: 927  ECGEGLRFRAVACSDKNGRPVDPSFCSSSGYIQEKCVIPCPFDCKLSDWSSWGSCSSS-- 984

Query: 165  LCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRR-VPC 206
             CG   G   R++ +   P      C       +  V   VPC
Sbjct: 985  -CGI--GVRIRSKWLKEKPYNGGRPCPKLDLKNQAQVHEAVPC 1024



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 30/116 (25%), Positives = 43/116 (37%), Gaps = 20/116 (17%)

Query: 99   IEHCEACFSHNFCT--KCKEGLYLHKGRCYPACPEGSSAANG-----------TMECS-- 143
            +EH  +C  +N     +C  G    K RC         A +            T  CS  
Sbjct: 1035 VEHWSSCKINNELRSLRCGGGTQSRKIRCVNTADGEGGAVDSNLCNQDEIPPETQSCSLM 1094

Query: 144  SPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRC 199
             P +C MSEW  W  C    Q C      + RTR +L  P  +   C++  + + C
Sbjct: 1095 CPNECVMSEWGLWSKC---PQSCD-PHTMQRRTRHLLR-PSLNSRTCAEDSQVQPC 1145



 Score = 32.7 bits (73), Expect = 0.33
 Identities = 30/111 (27%), Positives = 40/111 (36%), Gaps = 16/111 (14%)

Query: 141 ECSSPAQ--CEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRR 198
           EC+ P +  C  + WS + PCS   +    RR       R L         C D+     
Sbjct: 832 ECTVPCREDCTFTAWSKFTPCSTNCEATKSRR-------RQLTGKSRKKEKCQDSDLYPL 884

Query: 199 CTVRRVPCPEGQKRRKGG-------QGRRENANRNLARKESKEAGAGSRRR 242
                 PC E   +  G        +GRRE       + +SKE G G R R
Sbjct: 885 VETELCPCDEFISQPYGNWSDCILPEGRREPHRGLRVQADSKECGEGLRFR 935



 Score = 32.7 bits (73), Expect = 0.33
 Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 5/59 (8%)

Query: 148  CEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPC 206
            C++S W+ W  CS   Q CG   G   RTR ++    G+   C  T+ T+  T    PC
Sbjct: 1219 CQLSGWTAWTECS---QTCG-HGGRMSRTRFIIMPTQGEGRPC-PTELTQEKTCPVTPC 1272



 Score = 30.0 bits (66), Expect = 2.1
 Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 9/83 (10%)

Query: 120 LHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLC---GFRRGSEERT 176
           + K  C    P  S   N  + CS+   C +S WS WG C  +   C     ++G   R 
Sbjct: 430 VEKALCVGPAPLPSQLCN--IPCST--DCIVSSWSAWGLCIHEN--CHDPQGKKGFRTRQ 483

Query: 177 RRVLHAPVGDHAACSDTKETRRC 199
           R VL    G    C    E+  C
Sbjct: 484 RHVLMESTGPAGHCPHLVESVPC 506



 Score = 29.6 bits (65), Expect = 2.8
 Identities = 16/54 (29%), Positives = 23/54 (42%), Gaps = 5/54 (9%)

Query: 129 CPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRR--GSEERTRRVL 180
           CP        + E      C +SEW+ W  CS   Q C  +   G + R+R +L
Sbjct: 552 CPVPPPPERKSCEIPCRMDCVLSEWTEWSSCS---QSCSNKNSDGKQTRSRTIL 602



 Score = 28.9 bits (63), Expect = 4.8
 Identities = 18/62 (29%), Positives = 26/62 (41%), Gaps = 9/62 (14%)

Query: 145  PAQCEMSEWSPWGPCSKKQQLCGFRR-----GSEERTRRVLHAPVGDHAAC-SDTKETRR 198
            P  C ++EWS W  C   +  C   R     G + R+R  +     +  +C     ETR 
Sbjct: 1339 PGDCHLTEWSEWSTC---ELTCIDGRSFETVGRQSRSRTFIIQSFENQDSCPQQVLETRP 1395

Query: 199  CT 200
            CT
Sbjct: 1396 CT 1397


>gi|108773804 Fraser syndrome 1 [Homo sapiens]
          Length = 4011

 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 16/129 (12%)

Query: 44  CELCSEVN---GCLKCSPK---LFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
           C  C+ V+    CL CS       +  +   + Q G C+ SC  G++ A +     C+ C
Sbjct: 413 CPDCTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGWCVHSCGLGFYQAGS----LCLAC 468

Query: 98  KIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSPWG 157
           + + C  C S   C+ C+  L +  G+C P C +G        +  S A C  S    WG
Sbjct: 469 QPQ-CSTCTSGLECSSCQPPLLMRHGQCVPTCGDGF-----YQDRHSCAVCHESCAGCWG 522

Query: 158 PCSKKQQLC 166
           P  K    C
Sbjct: 523 PTEKHCLAC 531



 Score = 49.3 bits (116), Expect = 3e-06
 Identities = 37/131 (28%), Positives = 55/131 (41%), Gaps = 22/131 (16%)

Query: 39  ACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCK 98
           AC   C  C+    C  C P L        + + G C+P+C  G++     D + C  C 
Sbjct: 467 ACQPQCSTCTSGLECSSCQPPL--------LMRHGQCVPTCGDGFYQ----DRHSCAVCH 514

Query: 99  IEHCEACF--SHNFCTKCKEGLY-LHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWSP 155
            E C  C+  +   C  C++ L+ L  G C  +C +G     GT  CS+   C+ S    
Sbjct: 515 -ESCAGCWGPTEKHCLACRDPLHVLRDGGCESSCGKGFYNRQGT--CSA---CDQS-CDS 567

Query: 156 WGPCSKKQQLC 166
            GP S +   C
Sbjct: 568 CGPSSPRCLTC 578



 Score = 48.5 bits (114), Expect = 6e-06
 Identities = 35/122 (28%), Positives = 51/122 (41%), Gaps = 29/122 (23%)

Query: 39  ACAKGCELCSEVNG-CLKCSPKLFILLERNDIRQVGVCLPSCPPGYF-DARNPDMNKCIK 96
           AC + C+ C   +  CL C+ K  +          G C+  CP GY+ DA         +
Sbjct: 560 ACDQSCDSCGPSSPRCLTCTEKTVL--------HDGKCMSECPGGYYADATG-------R 604

Query: 97  CKIEH--CEACF--SHNFCTKCKEGLYLHKGRCYPACPEGSSAANGT--------MECSS 144
           CK+ H  C +C   + + CT C     L +G C P C EG  + +G         + C  
Sbjct: 605 CKVCHNSCASCSGPTPSHCTACSPPKALRQGHCLPRCGEGFYSDHGVCKACHSSCLACMG 664

Query: 145 PA 146
           PA
Sbjct: 665 PA 666



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 30/104 (28%), Positives = 39/104 (37%), Gaps = 11/104 (10%)

Query: 40   CAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKI 99
            C   C  C   + C +C    F+LLE         C+  C  GYF   +   +KC  C  
Sbjct: 1004 CDSYCLQCQGPHECTRCKGP-FLLLEAQ-------CVQECGKGYF--ADHAKHKCTACP- 1052

Query: 100  EHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECS 143
            + C  C   + C  C  G +L  G C   C  G S       CS
Sbjct: 1053 QGCLQCSHRDRCHLCDHGFFLKSGLCVYNCVPGFSVHTSNETCS 1096



 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 42/149 (28%), Positives = 60/149 (40%), Gaps = 26/149 (17%)

Query: 28  RQRRISAEGSQACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDAR 87
           + R   A   ++CA GC   +E + CL C   L +L +       G C  SC  G+++ +
Sbjct: 505 QDRHSCAVCHESCA-GCWGPTEKH-CLACRDPLHVLRD-------GGCESSCGKGFYNRQ 555

Query: 88  NPDMNKCIKCKIEHCEACF-SHNFCTKCKEGLYLHKGRCYPACPEGSSA---------AN 137
                 C  C  + C++C  S   C  C E   LH G+C   CP G  A          N
Sbjct: 556 GT----CSACD-QSCDSCGPSSPRCLTCTEKTVLHDGKCMSECPGGYYADATGRCKVCHN 610

Query: 138 GTMECSSPAQCEMSEWSPWGPCSKKQQLC 166
               CS P     +  SP  P + +Q  C
Sbjct: 611 SCASCSGPTPSHCTACSP--PKALRQGHC 637



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 26/83 (31%), Positives = 33/83 (39%), Gaps = 15/83 (18%)

Query: 53  CLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHN--F 110
           CL+C    ++LL  +       C+P CP GY+  R      C KC    C  C       
Sbjct: 827 CLRCQNAHYLLLGDH-------CVPDCPSGYYAER----GACKKCH-SSCRTCQGRGPFS 874

Query: 111 CTKCKEGLYL-HKGRCYPACPEG 132
           C+ C   L L H G C   C  G
Sbjct: 875 CSSCDTNLVLSHTGTCSTTCFPG 897



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 30/132 (22%), Positives = 49/132 (37%), Gaps = 26/132 (19%)

Query: 33   SAEGSQACAKGCELCSEV--NGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPD 90
            S    + C   C  CS      CL+C     +        Q G C+  C   ++     D
Sbjct: 951  STNTCKECDWSCSACSGPLKTDCLQCMDGYVL--------QDGACVEQCLSSFYQ----D 998

Query: 91   MNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEG----------SSAANGTM 140
               C KC   +C  C   + CT+CK    L + +C   C +G          ++   G +
Sbjct: 999  SGLC-KCD-SYCLQCQGPHECTRCKGPFLLLEAQCVQECGKGYFADHAKHKCTACPQGCL 1056

Query: 141  ECSSPAQCEMSE 152
            +CS   +C + +
Sbjct: 1057 QCSHRDRCHLCD 1068



 Score = 37.0 bits (84), Expect = 0.018
 Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 17/117 (14%)

Query: 40  CAKGCELCSEVN--GCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC 97
           C   C  C       C  C   L +          G C  +C PG++     D + C  C
Sbjct: 860 CHSSCRTCQGRGPFSCSSCDTNLVL-------SHTGTCSTTCFPGHY---LDDNHVCQPC 909

Query: 98  KIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMSEWS 154
              HC +C S   CT C++    +K   +  C   S A    ++ S+   C+  +WS
Sbjct: 910 NT-HCGSCDSQASCTSCRDP---NKVLLFGECQYESCAPQYYLDFSTNT-CKECDWS 961



 Score = 33.5 bits (75), Expect = 0.19
 Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 20/129 (15%)

Query: 29  QRRISAEGSQACAKGCELCSEVNGCLKCSPK----LFILLERNDIRQVGVCLPSC----- 79
           +++I   G++  +  C +CS  +G ++C+P+    L    +       G C P C     
Sbjct: 98  EKKIHEHGTEWASSPCSVCSCNHGEVRCTPQPCPPLSCGHQELAFIPEGSCCPVCVGLGK 157

Query: 80  PPGY-----FDARNPDMNKCIKCKIEHCEA-CFSHN----FCTKCKEGLYLHKGRCYPAC 129
           P  Y      D  +  +++C KC   +  A CF+      FC +  E +    G+C P C
Sbjct: 158 PCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTAQCQPLFCNQ-DETVVRVPGKCCPQC 216

Query: 130 PEGSSAANG 138
              S +A G
Sbjct: 217 SARSCSAAG 225



 Score = 31.6 bits (70), Expect = 0.74
 Identities = 30/115 (26%), Positives = 40/115 (34%), Gaps = 16/115 (13%)

Query: 38  QACAKGCELC-----SEVNGCLKCSPKLFILLERNDIRQVGV----CLPSCPPGYFDARN 88
           +AC   C  C     S   GC K    L +      +  VG+    CL  C   ++    
Sbjct: 653 KACHSSCLACMGPAPSHCTGCKKPEEGLQV----EQLSDVGIPSGECLAQCRAHFYLEST 708

Query: 89  PDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGT-MEC 142
                C +     C     HN CT C     L  G+C   CP+G     G+  EC
Sbjct: 709 GICEACHQSCFR-CAGKSPHN-CTDCGPSHVLLDGQCLSQCPDGYFHQEGSCTEC 761



 Score = 30.4 bits (67), Expect = 1.6
 Identities = 14/45 (31%), Positives = 22/45 (48%), Gaps = 8/45 (17%)

Query: 39   ACAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGY 83
            AC +GC  CS  + C  C    F+        + G+C+ +C PG+
Sbjct: 1050 ACPQGCLQCSHRDRCHLCDHGFFL--------KSGLCVYNCVPGF 1086


>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
           sapiens]
          Length = 1657

 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 23/68 (33%), Positives = 32/68 (47%), Gaps = 3/68 (4%)

Query: 142 CSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTV 201
           C    +C++SEWS W PCSK         G+  RTR +   P+G    C + +E   C  
Sbjct: 355 CVITKECQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLS 414

Query: 202 RR---VPC 206
           +    VPC
Sbjct: 415 QGDGVVPC 422



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 26/68 (38%), Positives = 34/68 (50%), Gaps = 9/68 (13%)

Query: 140  MECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAAC-SDTKETRR 198
            +EC  P  C++S+WSPW  CS   Q CG   G   R R V     GD   C S   +++ 
Sbjct: 1281 VEC--PVNCQLSDWSPWSECS---QTCGL-TGKMIRRRTVTQPFQGDGRPCPSLMDQSKP 1334

Query: 199  CTVRRVPC 206
            C V+  PC
Sbjct: 1335 CPVK--PC 1340



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 20/67 (29%), Positives = 32/67 (47%), Gaps = 9/67 (13%)

Query: 145 PAQCEMSEWSPWGPCSKKQQLCGFRRGSEE---RTRRVLHAPVGDHAACSDTKETRRCTV 201
           P +CE+S WS WGPC+ +   C  ++G +    R RR+ + P G      +        +
Sbjct: 510 PTECEVSPWSAWGPCTYEN--CNDQQGKKGFKLRKRRITNEPTGGSGVTGNCPH----LL 563

Query: 202 RRVPCPE 208
             +PC E
Sbjct: 564 EAIPCEE 570



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 28/116 (24%), Positives = 41/116 (35%), Gaps = 19/116 (16%)

Query: 102  CEACFSHNFCTKCKEGLYLHKGRC--------------YPACPEGSSAANGTMECSSPAQ 147
            C+  F  N    C EG+   K RC              Y   PE     +   +   P  
Sbjct: 1107 CKVTFV-NMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPLGSRVCKLPCPED 1165

Query: 148  CEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRR 203
            C +SEW PW  C        FR+ S +  R+    P  +  +C +  E   C + +
Sbjct: 1166 CVISEWGPWTQCVLPCNQSSFRQRSADPIRQ----PADEGRSCPNAVEKEPCNLNK 1217



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 36/133 (27%), Positives = 55/133 (41%), Gaps = 30/133 (22%)

Query: 142 CSSPAQ--CEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRC 199
           C  P Q  C +SE+S W  CSK    CG   G + RTR V+  P    + C +  E + C
Sbjct: 187 CLIPCQQDCIVSEFSAWSECSK---TCG--SGLQHRTRHVVAPPQFGGSGCPNLTEFQVC 241

Query: 200 TVRRVPCPEGQKR----------------RKGGQGRRENANRNLARKESK-----EAGAG 238
             +  PC   + R                R+  Q RR   N+   +  SK     EA   
Sbjct: 242 --QSSPCEAEELRYSLHVGPWSTCSMPHSRQVRQARRRGKNKEREKDRSKGVKDPEAREL 299

Query: 239 SRRRKGQQQQQQQ 251
            ++++ + +Q +Q
Sbjct: 300 IKKKRNRNRQNRQ 312



 Score = 34.7 bits (78), Expect = 0.087
 Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 6/63 (9%)

Query: 145  PAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRR- 203
            P+ C++SEWS W  CSK    CG   G + R++ +   P      C       +  V   
Sbjct: 1033 PSDCKLSEWSNWSRCSKS---CG--SGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEV 1087

Query: 204  VPC 206
            VPC
Sbjct: 1088 VPC 1090


>gi|14790170 tumor necrosis factor receptor superfamily, member 6b
           [Homo sapiens]
          Length = 300

 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 14/124 (11%)

Query: 53  CLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKI------EHCEACF 106
           C +C P  F+  +R   R        CPP ++      + +C  C +      E   AC 
Sbjct: 49  CAQCPPGTFV--QRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACH 106

Query: 107 S-HNFCTKCKEGLYLHKGRC--YPACPEGSSA-ANGTMECSSPAQCEMSEWSPWGPCSKK 162
           + HN   +C+ G + H G C  + +CP G+   A GT   S   QC+      +   S  
Sbjct: 107 ATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTP--SQNTQCQPCPPGTFSASSSS 164

Query: 163 QQLC 166
            + C
Sbjct: 165 SEQC 168


>gi|4507585 tumor necrosis factor receptor superfamily, member 6b
           [Homo sapiens]
          Length = 300

 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 14/124 (11%)

Query: 53  CLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKI------EHCEACF 106
           C +C P  F+  +R   R        CPP ++      + +C  C +      E   AC 
Sbjct: 49  CAQCPPGTFV--QRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACH 106

Query: 107 S-HNFCTKCKEGLYLHKGRC--YPACPEGSSA-ANGTMECSSPAQCEMSEWSPWGPCSKK 162
           + HN   +C+ G + H G C  + +CP G+   A GT   S   QC+      +   S  
Sbjct: 107 ATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTP--SQNTQCQPCPPGTFSASSSS 164

Query: 163 QQLC 166
            + C
Sbjct: 165 SEQC 168


>gi|190341087 spondin 2, extracellular matrix protein [Homo sapiens]
          Length = 331

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 8/77 (10%)

Query: 127 PACPEGSSAANGTMECSS----PAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHA 182
           P  P   S  N  ++ +S    P  CE+S WS WG C      CG R G++ RTR V   
Sbjct: 253 PPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGH---CG-RLGTKSRTRYVRVQ 308

Query: 183 PVGDHAACSDTKETRRC 199
           P  + + C + +E   C
Sbjct: 309 PANNGSPCPELEEEAEC 325


>gi|6912682 spondin 2, extracellular matrix protein [Homo sapiens]
          Length = 331

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 26/77 (33%), Positives = 36/77 (46%), Gaps = 8/77 (10%)

Query: 127 PACPEGSSAANGTMECSS----PAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHA 182
           P  P   S  N  ++ +S    P  CE+S WS WG C      CG R G++ RTR V   
Sbjct: 253 PPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGH---CG-RLGTKSRTRYVRVQ 308

Query: 183 PVGDHAACSDTKETRRC 199
           P  + + C + +E   C
Sbjct: 309 PANNGSPCPELEEEAEC 325


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 42.0 bits (97), Expect = 5e-04
 Identities = 46/177 (25%), Positives = 61/177 (34%), Gaps = 34/177 (19%)

Query: 40   CAKGCELCSEVNGCLKCSPKLFILLERNDIRQVG-VCLPSCPPGYFDARNPDMNKCIKCK 98
            C  GC    EV  C    P+    L+   + Q   VC   C             +C K  
Sbjct: 4058 CEAGCPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQKGC-------------RCPKGS 4104

Query: 99   IEHCEAC--FSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSS-----PAQCEMS 151
            +E    C    H  CT  +   +    +   AC   S  A G + C++     P  C  S
Sbjct: 4105 LEQDGGCVPIGHCDCTDAQGHSWAPGSQHQDACNNCSCQA-GQLSCTAQPCPPPTHCAWS 4163

Query: 152  EWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPE 208
             WS W PCS     CG  RG + R R           + S   E R    +  PCP+
Sbjct: 4164 HWSAWSPCSHS---CG-PRGQQSRFR--------SSTSGSWAPECREEQSQSQPCPQ 4208



 Score = 41.2 bits (95), Expect = 0.001
 Identities = 35/126 (27%), Positives = 43/126 (34%), Gaps = 32/126 (25%)

Query: 111  CTKCKEGLYLHKGRCYP--ACP-------------------EGSSAANGTMECSS---PA 146
            CT C  GL+LH   C P   CP                      +  +G M C+S   P 
Sbjct: 2926 CT-CPPGLFLHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPV 2984

Query: 147  QCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPV--GDHAACSDTKETRRCTVRRV 204
             C  S W+ W  CS     C    G   R R     P   G       T E   C++R  
Sbjct: 2985 ACGWSPWTLWSLCS-----CSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCSLRPC 3039

Query: 205  PCPEGQ 210
            P P G+
Sbjct: 3040 PGPGGE 3045



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 37/125 (29%), Positives = 47/125 (37%), Gaps = 32/125 (25%)

Query: 127  PACP-EGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVG 185
            P CP  G  A N          C  + W+PW PCS+    CG   G + R R       G
Sbjct: 3935 PVCPGPGCGAGN----------CSWTSWAPWEPCSRS---CGV--GQQRRLRAYRPPGPG 3979

Query: 186  DH---AACSDTKETRRCTVRRVPCPEGQKRRK----------GGQGRRENANRNLARKES 232
             H      +  +E R C +R  P P G  R            GGQ  R   +R+ +   S
Sbjct: 3980 GHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLR---SRSCSSPPS 4036

Query: 233  KEAGA 237
            K  GA
Sbjct: 4037 KNGGA 4041



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 45/158 (28%), Positives = 55/158 (34%), Gaps = 44/158 (27%)

Query: 68   DIRQVGVCLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYP 127
            D+ Q G+ +P CPP   D   P  N+   C     E C       +C  GL LH  RC P
Sbjct: 2625 DLCQKGL-VPPCPPSCLD---PKANR--SCSGHCVEGC-------RCPPGLLLHDTRCLP 2671

Query: 128  A--CP---------EGSS----------AANGTMECSS---PAQCEMSEWSPWGPCSKKQ 163
               CP          G S             G + C     P  C  S WS W PC +  
Sbjct: 2672 LSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRS- 2730

Query: 164  QLCGFRRGSEERTRRVLHAPV--GDHAACSDTKETRRC 199
              CG   G   R R   + P   G      D +E + C
Sbjct: 2731 --CG--SGVRARFRSPSNPPAAWGGAPCEGDRQELQGC 2764



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 35/124 (28%), Positives = 49/124 (39%), Gaps = 32/124 (25%)

Query: 113  KCKEGLYLHKGRCYP--ACPEGSSAANGTMECSSPAQ-----CE---------------- 149
            +C  G  +  GRC P  +C  G  +AN + E + PAQ     C+                
Sbjct: 4705 RCPPGQLVQDGRCVPISSCRCGLPSANASWELA-PAQAVQLDCQNCTCVNESLVCPHQEC 4763

Query: 150  --MSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVP-C 206
              +  WS W  CS     CG   G+ ER R     P        DT++ + C ++  P C
Sbjct: 4764 PVLGPWSAWSSCSAP---CG--GGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPCPEC 4818

Query: 207  PEGQ 210
            P GQ
Sbjct: 4819 PPGQ 4822



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 27/81 (33%), Positives = 35/81 (43%), Gaps = 9/81 (11%)

Query: 134  SAANGTMECSSP----AQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRR-VLHAPVGDHA 188
            S A+G + CS      A      WSPWGPCS+    CG   G+  R+R+ VL  P     
Sbjct: 3794 SCAHGKLSCSLDDCFEADGGFGPWSPWGPCSRS---CG-GLGTRTRSRQCVLTMPTLSGQ 3849

Query: 189  ACSDTKETRRCTVRRVPCPEG 209
             C   ++   C     P  EG
Sbjct: 3850 GCRGPRQDLECPSPDCPGAEG 3870



 Score = 38.1 bits (87), Expect = 0.008
 Identities = 25/78 (32%), Positives = 33/78 (42%), Gaps = 5/78 (6%)

Query: 138  GTMECSSPAQC-EMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKET 196
            G ++C     C +   WS WGP       CG   G + R+RR    P    A  S T  T
Sbjct: 3632 GILQCQEVPDCPDPGVWSSWGPWEDCSVSCG--GGEQLRSRRCARPPCPGPARQSRTCST 3689

Query: 197  RRCTVRRVPCPEGQKRRK 214
            + C  R   CP G+  R+
Sbjct: 3690 QVC--REAGCPAGRLYRE 3705



 Score = 37.7 bits (86), Expect = 0.010
 Identities = 27/79 (34%), Positives = 34/79 (43%), Gaps = 9/79 (11%)

Query: 130  PEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAA 189
            PE  S A  T  C  P   E S WSPW  CS+    C   RG+  R R+  H+P      
Sbjct: 1735 PEHQSQACFTAAC--PVDGEWSTWSPWSVCSEP---C---RGTMTRQRQ-CHSPQNGGRT 1785

Query: 190  CSDTKETRRCTVRRVPCPE 208
            C+        T +  PCP+
Sbjct: 1786 CAALPGGLHSTRQTKPCPQ 1804



 Score = 32.3 bits (72), Expect = 0.43
 Identities = 39/169 (23%), Positives = 64/169 (37%), Gaps = 21/169 (12%)

Query: 40   CAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKI 99
            C +  ++C     CL  S       ER+  R + + LPS P  +  +  P M   +    
Sbjct: 2403 CVEQAQVCDGREDCLDGSD------ERHCARNLLMWLPSLPALWAASTVPFMMPTMALPG 2456

Query: 100  EHCEACFSHNFCTKCKEGLYLH-KGRC--YPACPEGSSAANGTMECSSPAQCEMSEWSPW 156
                          C  G  L  + RC   P C +GS   +G ++C       ++ WS W
Sbjct: 2457 LPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDE-DGCVDCV------LAPWSVW 2509

Query: 157  GPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVP 205
              CS+    CG   G   + + +L  P+   +   D   ++ C V+  P
Sbjct: 2510 SSCSRS---CGL--GLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACP 2553



 Score = 32.3 bits (72), Expect = 0.43
 Identities = 24/85 (28%), Positives = 32/85 (37%), Gaps = 10/85 (11%)

Query: 101  HCEA--CFSHNFCTKCKEGLYLHKGRCYPACP------EGSSAANGTMECSSPAQCEMSE 152
            HC +     +N C   ++    H+G  YP         E  S  +G +   S   C   E
Sbjct: 3124 HCPSGMLLLNNVCVPTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIANCSSWPCAEGE 3183

Query: 153  --WSPWGPCSKKQQLCGFRRGSEER 175
              WSPW P S+    CG  R    R
Sbjct: 3184 PTWSPWTPWSQCSASCGPARCHRHR 3208



 Score = 32.0 bits (71), Expect = 0.57
 Identities = 42/165 (25%), Positives = 59/165 (35%), Gaps = 45/165 (27%)

Query: 75   CLPSCPPGYFDARNPDMNKCIKCKIEHC-EACFSHNFCTKCKEGLYLHKGRCY-PAC--- 129
            C P+CPP   + ++P+      C++  C E CF       C EG  LH G C  PA    
Sbjct: 1284 CGPTCPPTCHE-QHPEPGW--HCQVVACVEGCF-------CPEGTLLHGGACLEPASCPC 1333

Query: 130  -------PEGSSAANGTMECSSPAQCEMSEWSPWG----------PCSKKQQLCGFRRGS 172
                   P GS        C+    C+  +W   G           C++ + LC      
Sbjct: 1334 EWGRNSFPPGSVLQKDCGNCT----CQEGQWHCGGDGGHCEELVPACAEGEALC------ 1383

Query: 173  EERTRRVLHAPVGDHA-ACSDTKETRRCTVRRVPCPEGQKRRKGG 216
            +E    V H  + D+   C D  +   C      C EGQ     G
Sbjct: 1384 QENGHCVPHGWLCDNQDDCGDGSDEEGCAA--PGCGEGQMTCSSG 1426



 Score = 32.0 bits (71), Expect = 0.57
 Identities = 49/182 (26%), Positives = 58/182 (31%), Gaps = 55/182 (30%)

Query: 42   KGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLP--SCPPGYF--------------- 84
            +  E C +  G   C P+L  L +   I   G C P  +CPPG F               
Sbjct: 2893 RSAEQCHQEGG--PC-PRL-CLTQGPGIECTGFCAPGCTCPPGLFLHNASCLPRSQCPCQ 2948

Query: 85   ----------DARNPDMNKC------IKCKIEHCEACFSHNFCT-------KCKEGLY-- 119
                       AR    N C      + C  E C      +  T        C  G+   
Sbjct: 2949 LHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLWSLCSCSCNVGIRRR 3008

Query: 120  LHKGRCYPACPEGSSAANGTME---CS-SPAQCEMSEWSPWGPCSKKQQLCGFRRGSEER 175
               G   PA   G+     TME   CS  P      EW PW PCS     CG   G   R
Sbjct: 3009 FRAGTAPPAAFGGAECQGPTMEAEFCSLRPCPGPGGEWGPWSPCSVP---CG--GGYRNR 3063

Query: 176  TR 177
            TR
Sbjct: 3064 TR 3065



 Score = 32.0 bits (71), Expect = 0.57
 Identities = 28/96 (29%), Positives = 34/96 (35%), Gaps = 22/96 (22%)

Query: 76   LPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFC-----TKCKEGLYLHKG-RCYPAC 129
            LP C PG +         C K  +E    C     C     +    G+ L  G R    C
Sbjct: 4452 LPPCQPGCY---------CPKGLLEQAGGCIPPEECNCWHTSAAGAGMTLAPGDRLQLGC 4502

Query: 130  PEGSSAANGTMECSSPA------QCEMSEWSPWGPC 159
             E      G + C+S          E SEWSP GPC
Sbjct: 4503 KE-CECRRGELHCTSQGCQGLLPLSEWSEWSPCGPC 4537



 Score = 31.6 bits (70), Expect = 0.74
 Identities = 16/48 (33%), Positives = 20/48 (41%), Gaps = 15/48 (31%)

Query: 129  CPEGSS-----AANGTMECSSPAQCEMSE----------WSPWGPCSK 161
            CP G+        +G  +C  P Q   S           WSPWGPCS+
Sbjct: 1661 CPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSR 1708



 Score = 31.6 bits (70), Expect = 0.74
 Identities = 29/103 (28%), Positives = 36/103 (34%), Gaps = 15/103 (14%)

Query: 114  CKEGLYLHKGRCYPACPEGSSAA-----NGTMECSSPAQCEMSEWSPWGPCSKKQQLCGF 168
            C  G  +    C  A P   S         T +   P   E   W PWGPCS+    CG 
Sbjct: 4269 CGGGNQVRTRACRAAAPHHRSPPCLGPDTQTRQQPCPGLLEACSWGPWGPCSRS---CGP 4325

Query: 169  RRGSEERTRRVLHAPVGDHAACSDT---KETRRCTVRRVPCPE 208
               S   +   L A       C+ T    +T+ C     PCPE
Sbjct: 4326 GLASRSGSCPCLMAKA--DPTCNSTFLHLDTQGC--YSGPCPE 4364



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 24/77 (31%), Positives = 29/77 (37%), Gaps = 18/77 (23%)

Query: 148  CEMSEWSPW----GPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDT-KETRRCTVR 202
            C  S WSPW    GPC  +     FR  +  R       P G    C    ++ RRC   
Sbjct: 1910 CGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPR-------PSGRGRQCRGIHRKARRCQTE 1962

Query: 203  RVPCP----EGQKRRKG 215
              PC     +GQ  R G
Sbjct: 1963 --PCEGCEHQGQVHRVG 1977



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 28/108 (25%), Positives = 38/108 (35%), Gaps = 14/108 (12%)

Query: 122  KGRCYPACPEGSSAANGTME--CSSPAQCEMSE----WSPWGPCSKKQQLCGFRRGSEER 175
            + R  P+  + S   + T E  CS P  C +      W+PW  CS          G + R
Sbjct: 2800 RSRLCPSPGDSSCPGDATQEEPCSPPV-CPVPSIWGLWAPWSTCSAPCD-----GGIQTR 2853

Query: 176  TRRVLHAPVGDHAACSDTKETRRCTVR--RVPCPEGQKRRKGGQGRRE 221
             R       GD        +TR C  +     CPE    R   Q  +E
Sbjct: 2854 GRSCSSLAPGDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQE 2901



 Score = 30.0 bits (66), Expect = 2.1
 Identities = 23/82 (28%), Positives = 29/82 (35%), Gaps = 10/82 (12%)

Query: 142  CSSPAQCEMS-EWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPV--GDHAACSDTKETRR 198
            C S A C +   W PWGP S     C    G   R+R     P   G      +  ++R 
Sbjct: 3463 CPSYATCPVDGAWGPWGPWSP----CDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRP 3518

Query: 199  CTVRRVPCPE---GQKRRKGGQ 217
            C      C +   GQ     GQ
Sbjct: 3519 CQENSTQCTDCGGGQSLHPCGQ 3540



 Score = 29.3 bits (64), Expect = 3.7
 Identities = 20/82 (24%), Positives = 27/82 (32%), Gaps = 5/82 (6%)

Query: 128  ACPEGSSAANGTMECSSPAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDH 187
            +CP     +      + P     + W  WGPCS     CG   G + R R  +  P  + 
Sbjct: 2536 SCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCSVS---CG--GGHQSRQRSCVDPPPKNG 2590

Query: 188  AACSDTKETRRCTVRRVPCPEG 209
             A        R      PC  G
Sbjct: 2591 GAPCPGASQERAPCGLQPCSGG 2612



 Score = 28.5 bits (62), Expect = 6.2
 Identities = 16/55 (29%), Positives = 21/55 (38%), Gaps = 2/55 (3%)

Query: 153  WSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCP 207
            W PWGP S   + CG   G   RTR     P        +    +    + +PCP
Sbjct: 3255 WGPWGPWSHCSRSCG--GGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCP 3307



 Score = 28.1 bits (61), Expect = 8.2
 Identities = 8/15 (53%), Positives = 9/15 (60%)

Query: 145  PAQCEMSEWSPWGPC 159
            P  C+ S W PW PC
Sbjct: 4613 PDSCQWSLWGPWSPC 4627


>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
          Length = 1522

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 28/98 (28%), Positives = 37/98 (37%), Gaps = 7/98 (7%)

Query: 114 CKEGLYLHKGRCYPACPEGSSAANG---TMECSSPAQCEMSEWSPWGPCSKKQQLCGFRR 170
           C  G      +C  A   GS        + EC +P      +W+ WG  S   + C    
Sbjct: 416 CSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNPECTANGQWNQWGHWSGCSKSCD--- 472

Query: 171 GSEERTRRVLHAPVGDHAACSDT-KETRRCTVRRVPCP 207
           G  ER  R     V     C  T +E RRC+ +R P P
Sbjct: 473 GGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRCPAP 510



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 26/99 (26%), Positives = 35/99 (35%), Gaps = 14/99 (14%)

Query: 114 CKEGLYLHKGRCYPACPEGSSAANGTME---CSSPAQCEM----SEWSPWGPCSKKQQLC 166
           C +G  +    C    P G+  +    E   C++ A C +     EWSPW  CS     C
Sbjct: 307 CGQGSQVRTRTC--VSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCS---FTC 361

Query: 167 GFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVP 205
           G  RG   RTR       G           + C +   P
Sbjct: 362 G--RGQRTRTRSCTPPQYGGRPCEGPETHHKPCNIALCP 398



 Score = 30.4 bits (67), Expect = 1.6
 Identities = 19/50 (38%), Positives = 27/50 (54%), Gaps = 7/50 (14%)

Query: 150 MSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRC 199
           + EWS W  CS     CG  +GS+ RTR  + +P G H +    +E+R C
Sbjct: 294 VEEWSQWSTCS---VTCG--QGSQVRTRTCV-SPYGTHCS-GPLRESRVC 336



 Score = 28.1 bits (61), Expect = 8.2
 Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 5/55 (9%)

Query: 145 PAQCEMSEWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRC 199
           P   +  EWS W  CS     C    G+++R+R+   A  G         E+R C
Sbjct: 398 PVDGQWQEWSSWSQCS---VTCS--NGTQQRSRQCTAAAHGGSECRGPWAESREC 447


>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
           sapiens]
          Length = 1037

 Score = 38.9 bits (89), Expect = 0.005
 Identities = 44/193 (22%), Positives = 66/193 (34%), Gaps = 48/193 (24%)

Query: 39  ACAKGCE-----LCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNK 93
           +C   C+     +CS   G   C+P                C   CP G F         
Sbjct: 489 SCNASCQCAHEAVCSPQTGACTCTPGW----------HGAHCQLPCPKGQFGE-----GC 533

Query: 94  CIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMSEW 153
             +C  +H + C   +   +C+ G      RC+ +CPEG    N    CS+   C+    
Sbjct: 534 ASRCDCDHSDGCDPVHGRCQCQAGWM--GARCHLSCPEGLWGVN----CSNTCTCKNG-- 585

Query: 154 SPWGPCSKKQQLC----GFRRGSEERT-------RRVLHAPVGDHAACSDTKETRRCTVR 202
              G C  +   C    GFR  S +R+       +R +     +H+ C  +  T  C   
Sbjct: 586 ---GTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAG 642

Query: 203 ------RVPCPEG 209
                   PCP G
Sbjct: 643 WTGPDCSQPCPPG 655



 Score = 36.6 bits (83), Expect = 0.023
 Identities = 24/78 (30%), Positives = 29/78 (37%), Gaps = 11/78 (14%)

Query: 75  CLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSS 134
           C   CPPG++       N    C+  H   C   +    C  G   H   C   CP G+ 
Sbjct: 648 CSQPCPPGHWGE-----NCAQTCQCHHGGTCHPQDGSCICPLGWTGH--HCLEGCPLGTF 700

Query: 135 AANGTMECSSPAQCEMSE 152
            AN    CS P QC   E
Sbjct: 701 GAN----CSQPCQCGPGE 714



 Score = 34.3 bits (77), Expect = 0.11
 Identities = 20/74 (27%), Positives = 27/74 (36%), Gaps = 12/74 (16%)

Query: 75  CLPSCPPGYFDARNPDMNKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSS 134
           C  SC PG +  R      C+ CK      C +H+FC       Y   G   P C +   
Sbjct: 606 CQRSCQPGRYGKR------CVPCK------CANHSFCHPSNGTCYCLAGWTGPDCSQPCP 653

Query: 135 AANGTMECSSPAQC 148
             +    C+   QC
Sbjct: 654 PGHWGENCAQTCQC 667



 Score = 31.2 bits (69), Expect = 0.96
 Identities = 22/72 (30%), Positives = 29/72 (40%), Gaps = 16/72 (22%)

Query: 108 HNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCE----------MSEWSP-- 155
           H    +C  G Y  +G C P C +     +G   C +P QC+           SE +P  
Sbjct: 84  HRQRLQCCHGFYESRGFCVPLCAQ--ECVHG--RCVAPNQCQCVPGWRGDDCSSECAPGM 139

Query: 156 WGPCSKKQQLCG 167
           WGP   K   CG
Sbjct: 140 WGPQCDKPCSCG 151



 Score = 28.1 bits (61), Expect = 8.2
 Identities = 30/131 (22%), Positives = 42/131 (32%), Gaps = 20/131 (15%)

Query: 37  SQACAKG-----CELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDM 91
           S  CA G     C+          C PK  +    + ++    CL  C PGY+    P  
Sbjct: 132 SSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPN-CLQPCTPGYY---GPAC 187

Query: 92  NKCIKCKIEHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSSPAQCEMS 151
               +C    C+      FC   + G         P+C    S       C S   C+  
Sbjct: 188 QFRCQCHGAPCDPQTGACFCPAERTG---------PSCDVSCSQGTSGFFCPSTHSCQNG 238

Query: 152 E--WSPWGPCS 160
               +P G CS
Sbjct: 239 GVFQTPQGSCS 249


>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
          Length = 1585

 Score = 38.1 bits (87), Expect = 0.008
 Identities = 34/125 (27%), Positives = 51/125 (40%), Gaps = 8/125 (6%)

Query: 114 CKEGLYLHKGRCYPACPEG---SSAANGTMECSSPAQCEM-SEWSPWGPCSKKQQLCGFR 169
           C +GL +    C  + P G   S     T  C++ A C +   W  WG  S   + CG  
Sbjct: 325 CGQGLQVRTRSCVSS-PYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCG-- 381

Query: 170 RGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPEGQKRRKGGQGRRENANRNLAR 229
           RGS  R R  +    G  A      +T+ C++   P  EGQ    G  G    +  N  +
Sbjct: 382 RGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPV-EGQWLEWGPWGPCSTSCANGTQ 440

Query: 230 KESKE 234
           + S++
Sbjct: 441 QRSRK 445



 Score = 37.4 bits (85), Expect = 0.013
 Identities = 31/109 (28%), Positives = 44/109 (40%), Gaps = 16/109 (14%)

Query: 107 SHNFCTK-CKEGLYLHKGRCYPACPEGSSAANG----TMECSS---PAQCEMSEWSPWGP 158
           S + C++ C  G       C P    G  A  G    T  CS    P + +  EW PWGP
Sbjct: 372 SWSLCSRSCGRGSRSRMRTCVPP-QHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGP 430

Query: 159 CSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCP 207
           CS     C    G+++R+R+   A            +TR C+   + CP
Sbjct: 431 CSTS---CA--NGTQQRSRKCSVAGPAWATCTGALTDTRECS--NLECP 472



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 9/57 (15%)

Query: 152 EWSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACS-DTKETRRCTVRRVPCP 207
           EWSPW  CS     CG  +G + RTR  + +P G    CS   +ETR C      CP
Sbjct: 314 EWSPWSVCS---LTCG--QGLQVRTRSCVSSPYG--TLCSGPLRETRPCN-NSATCP 362


>gi|192449445 cartilage intermediate layer protein [Homo sapiens]
          Length = 1184

 Score = 37.4 bits (85), Expect = 0.013
 Identities = 24/64 (37%), Positives = 30/64 (46%), Gaps = 10/64 (15%)

Query: 153 WSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKET------RRCTVRRVPC 206
           WSPW P SK    CG + G + RTR  L   V   + CS+  E       + CT   + C
Sbjct: 152 WSPWSPWSKCSAACG-QTGVQTRTRICLAEMV---SLCSEASEEGQHCMGQDCTACDLTC 207

Query: 207 PEGQ 210
           P GQ
Sbjct: 208 PMGQ 211


>gi|31657140 insulin receptor-related receptor precursor [Homo
           sapiens]
          Length = 1297

 Score = 37.0 bits (84), Expect = 0.018
 Identities = 26/116 (22%), Positives = 43/116 (37%), Gaps = 23/116 (19%)

Query: 40  CAKGCELCSEVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKCKI 99
           C  GC    +   C+ C    F           G CL +CPPG +   +    +C+    
Sbjct: 233 CLGGCSQPEDPRACVACRHLYF----------QGACLWACPPGTYQYESW---RCVTA-- 277

Query: 100 EHCEACFSHNFCTKCKEGLYLHKGRCYPACPEGSSAANGTMECSS-----PAQCEM 150
              E C S +          +H+G C   CP G +  + ++ C       P +C++
Sbjct: 278 ---ERCASLHSVPGRASTFGIHQGSCLAQCPSGFTRNSSSIFCHKCEGLCPKECKV 330


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
           sapiens]
          Length = 1367

 Score = 37.0 bits (84), Expect = 0.018
 Identities = 35/136 (25%), Positives = 44/136 (32%), Gaps = 35/136 (25%)

Query: 36  GSQACAKGCELCS-EVNGCLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKC 94
           G +AC +  E C  E  G           +        GVC+P+CPP  +          
Sbjct: 220 GKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEG------ 273

Query: 95  IKCKIEHCEACFSHNFCTKC-------KEGLYLHKGRCYPACPEGSSAANG--TMECSSP 145
                     C   +FC           EG  +H G C   CP G    NG  +M C   
Sbjct: 274 --------WRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSG-FIRNGSQSMYC--- 321

Query: 146 AQCEMSEWSPWGPCSK 161
             CE       GPC K
Sbjct: 322 IPCE-------GPCPK 330


>gi|4505737 complement factor properdin precursor [Homo sapiens]
          Length = 469

 Score = 36.6 bits (83), Expect = 0.023
 Identities = 23/70 (32%), Positives = 29/70 (41%), Gaps = 8/70 (11%)

Query: 142 CSSPAQCEMSE-WSPWGPCSKKQQLCGFRRGSEERTRRVLHAPVGDHA---ACSDTKETR 197
           C+    C ++  W PWGP S     CG  +  E+RT    + PV  H       D   T 
Sbjct: 248 CTGLPPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRT---CNHPVPQHGGPFCAGDATRTH 304

Query: 198 RCTVRRVPCP 207
            C    VPCP
Sbjct: 305 ICNT-AVPCP 313



 Score = 31.6 bits (70), Expect = 0.74
 Identities = 35/105 (33%), Positives = 43/105 (40%), Gaps = 17/105 (16%)

Query: 114 CKEGLYLHKGRCYPACPEGSS-AANGTMECSSPA----QC--EMSEWS---PWGPCSKKQ 163
           C EG  L   RC     + S   A GT+E    A    QC  EM  WS   PW PCS   
Sbjct: 93  CSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGWSGWGPWEPCS--- 149

Query: 164 QLCGFRRGSEERTRRVLH-APVGDHAACSDTKETRRCTVRRVPCP 207
             C   +G+  R R   H AP          +E+  C  ++V CP
Sbjct: 150 VTCS--KGTRTRRRACNHPAPKCGGHCPGQAQESEACDTQQV-CP 191


>gi|148743793 osteoprotegerin precursor [Homo sapiens]
          Length = 401

 Score = 36.6 bits (83), Expect = 0.023
 Identities = 41/171 (23%), Positives = 68/171 (39%), Gaps = 22/171 (12%)

Query: 53  CLKCSPKLFILLERNDIRQVGVCLPSCPPGYFDARNPDMNKCIKC-----KIEHC--EAC 105
           C KC P  + L +    +   VC P CP  Y+       ++C+ C     ++++   E  
Sbjct: 41  CDKCPPGTY-LKQHCTAKWKTVCAP-CPDHYYTDSWHTSDECLYCSPVCKELQYVKQECN 98

Query: 106 FSHNFCTKCKEGLYLHKGRC--YPACPEGSSAAN-GTMECSS-----PAQCEMSEWSPWG 157
            +HN   +CKEG YL    C  + +CP G      GT E ++     P     +E S   
Sbjct: 99  RTHNRVCECKEGRYLEIEFCLKHRSCPPGFGVVQAGTPERNTVCKRCPDGFFSNETSSKA 158

Query: 158 PCSKKQQLCGFRRGSEERTRRVLHAPVGDHAACSDTKETRRCTVRRVPCPE 208
           PC K      F     ++          D+    +++ T++C +    C E
Sbjct: 159 PCRKHTNCSVFGLLLTQKGN-----ATHDNICSGNSESTQKCGIDVTLCEE 204


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.134    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,377,224
Number of Sequences: 37866
Number of extensions: 646533
Number of successful extensions: 3572
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 133
Number of HSP's that attempted gapping in prelim test: 3159
Number of HSP's gapped (non-prelim): 482
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.