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Search of human proteins with 83816971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83816971 DIX domain containing 1 isoform a [Homo sapiens]
(683 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83816971 DIX domain containing 1 isoform a [Homo sapiens] 1356 0.0
gi|39930479 DIX domain containing 1 isoform b [Homo sapiens] 927 0.0
gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens] 82 2e-15
gi|161169013 neuron navigator 2 isoform 1 [Homo sapiens] 81 4e-15
gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens] 81 4e-15
gi|4758216 dishevelled 2 [Homo sapiens] 77 5e-14
gi|120953251 neuron navigator 3 [Homo sapiens] 77 5e-14
gi|32479521 dishevelled 1 [Homo sapiens] 72 1e-12
gi|41406097 dishevelled 3 [Homo sapiens] 72 1e-12
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 72 2e-12
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 72 2e-12
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 72 2e-12
gi|12025678 actinin, alpha 4 [Homo sapiens] 71 3e-12
gi|4557241 actinin, alpha 3 [Homo sapiens] 69 2e-11
gi|4501893 actinin, alpha 2 [Homo sapiens] 66 1e-10
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 64 4e-10
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 64 4e-10
gi|154277116 spectrin repeat containing, nuclear envelope 1 isof... 64 6e-10
gi|67782321 spectrin beta isoform a [Homo sapiens] 59 1e-08
gi|67782319 spectrin beta isoform b [Homo sapiens] 59 1e-08
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 59 2e-08
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 58 3e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 58 3e-08
gi|19923599 calmin [Homo sapiens] 58 3e-08
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 57 4e-08
gi|23097308 spectrin repeat containing, nuclear envelope 1 isofo... 57 7e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 7e-08
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 56 1e-07
gi|34577047 dystonin isoform 1 [Homo sapiens] 56 1e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 56 1e-07
>gi|83816971 DIX domain containing 1 isoform a [Homo sapiens]
Length = 683
Score = 1356 bits (3509), Expect = 0.0
Identities = 683/683 (100%), Positives = 683/683 (100%)
Query: 1 MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLI 60
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLI
Sbjct: 1 MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLI 60
Query: 61 EIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVL 120
EIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVL
Sbjct: 61 EIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVL 120
Query: 121 ALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRY 180
ALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRY
Sbjct: 121 ALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAAAALADVCHDMSRSGRDVFRY 180
Query: 181 RQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEE 240
RQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEE
Sbjct: 181 RQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCSSLTSPSPIHSAKSESIITQSEE 240
Query: 241 KADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKK 300
KADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKK
Sbjct: 241 KADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKK 300
Query: 301 MISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKC 360
MISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKC
Sbjct: 301 MISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKC 360
Query: 361 KQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLL 420
KQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLL
Sbjct: 361 KQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLL 420
Query: 421 GEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEA 480
GEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEA
Sbjct: 421 GEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEA 480
Query: 481 TNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSL 540
TNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSL
Sbjct: 481 TNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSL 540
Query: 541 EQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTC 600
EQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTC
Sbjct: 541 EQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTC 600
Query: 601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH 660
TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH
Sbjct: 601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH 660
Query: 661 DDDAIPGWEGKIVAWVEEDHGEN 683
DDDAIPGWEGKIVAWVEEDHGEN
Sbjct: 661 DDDAIPGWEGKIVAWVEEDHGEN 683
>gi|39930479 DIX domain containing 1 isoform b [Homo sapiens]
Length = 472
Score = 927 bits (2397), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 220 LTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETS 279
LTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETS
Sbjct: 9 LTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETS 68
Query: 280 WEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII 339
WEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII
Sbjct: 69 WEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIII 128
Query: 340 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 399
QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK
Sbjct: 129 QSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK 188
Query: 400 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 459
DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE
Sbjct: 189 DELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLE 248
Query: 460 RELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA 519
RELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA
Sbjct: 249 RELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA 308
Query: 520 LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE 579
LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE
Sbjct: 309 LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRVKSPRTQVGSEYRE 368
Query: 580 SWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGN 639
SWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGN
Sbjct: 369 SWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGN 428
Query: 640 HRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN 683
HRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN
Sbjct: 429 HRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGEN 472
>gi|161169015 neuron navigator 2 isoform 3 [Homo sapiens]
Length = 2365
Score = 82.0 bits (201), Expect = 2e-15
Identities = 40/106 (37%), Positives = 67/106 (63%)
Query: 20 EQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQ 79
E Q + Y W N L K + ++DL+QD+ DGV+LA +I++VA EK+ + P N+
Sbjct: 21 EDQKRIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCPKNRS 80
Query: 80 EMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAH 125
+M N++ L F+A+K I + SA++I +GNLK+I+ L +L+ +
Sbjct: 81 QMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRY 126
>gi|161169013 neuron navigator 2 isoform 1 [Homo sapiens]
Length = 2432
Score = 80.9 bits (198), Expect = 4e-15
Identities = 41/112 (36%), Positives = 70/112 (62%), Gaps = 3/112 (2%)
Query: 14 LQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQL 73
++ GF+ Q Y W N L K + ++DL+QD+ DGV+LA +I++VA EK+ +
Sbjct: 82 VENGFDTQ---IYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDING 138
Query: 74 SPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAH 125
P N+ +M N++ L F+A+K I + SA++I +GNLK+I+ L +L+ +
Sbjct: 139 CPKNRSQMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRY 190
>gi|38044282 neuron navigator 2 isoform 2 [Homo sapiens]
Length = 2429
Score = 80.9 bits (198), Expect = 4e-15
Identities = 41/112 (36%), Positives = 70/112 (62%), Gaps = 3/112 (2%)
Query: 14 LQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQL 73
++ GF+ Q Y W N L K + ++DL+QD+ DGV+LA +I++VA EK+ +
Sbjct: 82 VENGFDTQ---IYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDING 138
Query: 74 SPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAH 125
P N+ +M N++ L F+A+K I + SA++I +GNLK+I+ L +L+ +
Sbjct: 139 CPKNRSQMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRY 190
>gi|4758216 dishevelled 2 [Homo sapiens]
Length = 736
Score = 77.0 bits (188), Expect = 5e-14
Identities = 33/76 (43%), Positives = 50/76 (65%)
Query: 601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH 660
TKV+Y D TP++V IP E +TL DFK+ + R +Y FK++D +FG VKEEI
Sbjct: 14 TKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISD 73
Query: 661 DDDAIPGWEGKIVAWV 676
D+ +P + G++V+W+
Sbjct: 74 DNARLPCFNGRVVSWL 89
>gi|120953251 neuron navigator 3 [Homo sapiens]
Length = 2363
Score = 77.0 bits (188), Expect = 5e-14
Identities = 37/106 (34%), Positives = 67/106 (63%)
Query: 20 EQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQ 79
++ + Y W N L K + ++DL+QD+ DGV+LA +I+I+A EK+ + P +Q
Sbjct: 77 KEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCPRSQS 136
Query: 80 EMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAH 125
+M NV+ L F+A++ + + SA++I +GNLK+I+ L +L+ +
Sbjct: 137 QMIENVDVCLSFLAARGVNVQGLSAEEIRNGNLKAILGLFFSLSRY 182
>gi|32479521 dishevelled 1 [Homo sapiens]
Length = 670
Score = 72.4 bits (176), Expect = 1e-12
Identities = 33/78 (42%), Positives = 49/78 (62%), Gaps = 2/78 (2%)
Query: 601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHF--KALDPEFGTVKEEI 658
TK++Y D TP++V +P E VTL DFK + H Y F K++D +FG VKEEI
Sbjct: 4 TKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEI 63
Query: 659 FHDDDAIPGWEGKIVAWV 676
F D+ +P + G++V+W+
Sbjct: 64 FDDNAKLPCFNGRVVSWL 81
>gi|41406097 dishevelled 3 [Homo sapiens]
Length = 716
Score = 72.4 bits (176), Expect = 1e-12
Identities = 32/83 (38%), Positives = 53/83 (63%), Gaps = 1/83 (1%)
Query: 601 TKVLYFTDRSLTPFMVNIPKRLEEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFH 660
TK++Y D TP++V +P E VTL DFK + R ++++ FK++D +FG VKEEI
Sbjct: 4 TKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRP-SYKFFFKSMDDDFGVVKEEISD 62
Query: 661 DDDAIPGWEGKIVAWVEEDHGEN 683
D+ +P + G++V+W+ G +
Sbjct: 63 DNAKLPCFNGRVVSWLVSAEGSH 85
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 71.6 bits (174), Expect = 2e-12
Identities = 35/114 (30%), Positives = 69/114 (60%), Gaps = 3/114 (2%)
Query: 13 VLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQ 72
+L + +QQ + + AW N+ L+K A ++++ +D RDG+ L L+E+++GE+L+ +
Sbjct: 24 LLDPAWEKQQRKTFTAWCNSHLRK--AGTQIENIEEDFRDGLKLMLLLEVISGERLAKPE 81
Query: 73 LSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
++ +NV K L F+ASK +++ A++IVDGN+K + ++ + F
Sbjct: 82 RGKMRVHKI-SNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRF 134
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 71.6 bits (174), Expect = 2e-12
Identities = 35/114 (30%), Positives = 69/114 (60%), Gaps = 3/114 (2%)
Query: 13 VLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQ 72
+L + +QQ + + AW N+ L+K A ++++ +D RDG+ L L+E+++GE+L+ +
Sbjct: 24 LLDPAWEKQQRKTFTAWCNSHLRK--AGTQIENIEEDFRDGLKLMLLLEVISGERLAKPE 81
Query: 73 LSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
++ +NV K L F+ASK +++ A++IVDGN+K + ++ + F
Sbjct: 82 RGKMRVHKI-SNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRF 134
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 71.6 bits (174), Expect = 2e-12
Identities = 35/114 (30%), Positives = 69/114 (60%), Gaps = 3/114 (2%)
Query: 13 VLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQ 72
+L + +QQ + + AW N+ L+K A ++++ +D RDG+ L L+E+++GE+L+ +
Sbjct: 24 LLDPAWEKQQRKTFTAWCNSHLRK--AGTQIENIEEDFRDGLKLMLLLEVISGERLAKPE 81
Query: 73 LSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
++ +NV K L F+ASK +++ A++IVDGN+K + ++ + F
Sbjct: 82 RGKMRVHKI-SNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRF 134
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 71.2 bits (173), Expect = 3e-12
Identities = 36/114 (31%), Positives = 67/114 (58%), Gaps = 3/114 (2%)
Query: 13 VLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQ 72
+L + +QQ + + AW N+ L+K A ++++ +D RDG+ L L+E+++GE+L +
Sbjct: 43 LLDPAWEKQQRKTFTAWCNSHLRK--AGTQIENIDEDFRDGLKLMLLLEVISGERLPKPE 100
Query: 73 LSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
++ NNV K L F+ASK +++ A++IVDGN K + ++ + F
Sbjct: 101 RGKMRVHKI-NNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRF 153
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 68.6 bits (166), Expect = 2e-11
Identities = 37/115 (32%), Positives = 68/115 (59%), Gaps = 5/115 (4%)
Query: 13 VLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQ 72
+L + +QQ + + AW N+ L+K A ++++ +D R+G+ L L+E+++GE+L +
Sbjct: 38 LLDPAWEKQQRKTFTAWCNSHLRK--AGTQIENIEEDFRNGLKLMLLLEVISGERLP--R 93
Query: 73 LSPGNQQEMK-NNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
G + K NV K L F+ASK +++ A++IVDGNLK + ++ + F
Sbjct: 94 PDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRF 148
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 65.9 bits (159), Expect = 1e-10
Identities = 33/114 (28%), Positives = 66/114 (57%), Gaps = 3/114 (2%)
Query: 13 VLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQ 72
+L + +QQ + + AW N+ L+K A ++++ +D R+G+ L L+E+++GE+L
Sbjct: 31 LLDPAWEKQQRKTFTAWCNSHLRK--AGTQIENIEEDFRNGLKLMLLLEVISGERLPKPD 88
Query: 73 LSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
++ N V K L ++ASK +++ A++IVDGN+K + ++ + F
Sbjct: 89 RGKMRFHKIAN-VNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRF 141
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform
5 [Homo sapiens]
Length = 6907
Score = 64.3 bits (155), Expect = 4e-10
Identities = 33/113 (29%), Positives = 63/113 (55%), Gaps = 2/113 (1%)
Query: 14 LQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQL 73
LQ + Q +A+ W+N+QL + + + DL D++ G +L L+E+++G++L +
Sbjct: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
Query: 74 SPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
S N + + N+E L F+ ++ I++ DI+DGN I+ L+ + HF
Sbjct: 85 S--NTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHF 135
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/265 (22%), Positives = 116/265 (43%), Gaps = 30/265 (11%)
Query: 232 ESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYL 291
E+ T++E K V + A + + DS +S + L +EE + ++ +L
Sbjct: 2862 ETAATEAELKHHHVTLEAS--QKELQEIDSGISTHLQE------LTNIYEELNVFERLFL 2913
Query: 292 EKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQ 351
E +++ K + +Q + N +E E + C E+ +Q D
Sbjct: 2914 EDQLKNLKIRTNRIQRFIQNTC---NEVEHKIKFCRQF---HEKTSALQEEADSIQRNEL 2967
Query: 352 DLKKELLK-CKQEARNLQGIKDALQQRLTQQDTSVLQLKQ--ELLRANMD---KDELHNQ 405
L +E+ K K+E NL+ A++ + Q VL+LK+ + + N D D+L Q
Sbjct: 2968 LLNQEVNKGVKEEIYNLKDRLTAIKCCILQ----VLKLKKVFDYIGLNWDFSQLDQLQTQ 3023
Query: 406 NVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQA------KLEEALRKLSDVSYHQVDLE 459
+ +++L+E+ + L +++E G+ LL + +A K+ E + K D S L
Sbjct: 3024 VFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLN 3083
Query: 460 RELEHKDVLLAHCMKREADEATNYN 484
++ + + A C+ E + N N
Sbjct: 3084 AQILSQRIEKAKCLCDEIIKKLNEN 3108
Score = 33.5 bits (75), Expect = 0.67
Identities = 33/165 (20%), Positives = 74/165 (44%), Gaps = 10/165 (6%)
Query: 282 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 341
E+L E+ + E++ E + ++ +Q LL + +P + Q ++ + ++ + +S
Sbjct: 1680 ERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNK-MEHVQKCLTGES 1738
Query: 342 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQD-----TSVLQLKQELLRAN 396
+L+++L +A+ G+ ++L + L+ D T + +++Q++L+
Sbjct: 1739 NCHALSGSTAELREDL----DQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQK 1794
Query: 397 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKL 441
L NQ L +L E + K +LQ H +KL
Sbjct: 1795 HSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL 1839
Score = 31.2 bits (69), Expect = 3.3
Identities = 67/292 (22%), Positives = 113/292 (38%), Gaps = 42/292 (14%)
Query: 277 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 336
ET W EQ+ E + EK + K+ S LQ E+ E +L E+ L
Sbjct: 4809 ETFWAEQVTEVKILEEKSRQCGMKLQSLLQKW-------EEFDENYASL-------EKDL 4854
Query: 337 IIIQSRLD--QSMEENQDLKKELLKCKQE-ARNLQGIKDALQQRLTQQDTSVLQLKQELL 393
I+ S L +EE ++ E + Q+ RN+ G L Q L + V + L
Sbjct: 4855 EILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPEL 4914
Query: 394 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSY 453
+ K L Q + L +K+D L K L +R Q LE + L+
Sbjct: 4915 EGQIAK--LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972
Query: 454 HQVDLERELE--HKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTS 511
+++ ++L+ ++ +E DE ++ T+V + G
Sbjct: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK------------------TAVISIGNQ 5014
Query: 512 DLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERK 563
L L +LR S + + Q T+ L + + E+LH ++ +K RK
Sbjct: 5015 LLHLKETDTATLRASLAQFE-QKWTM--LITQLPDIQEKLHQLQMEKLPSRK 5063
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform
1 [Homo sapiens]
Length = 6885
Score = 64.3 bits (155), Expect = 4e-10
Identities = 33/113 (29%), Positives = 63/113 (55%), Gaps = 2/113 (1%)
Query: 14 LQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQL 73
LQ + Q +A+ W+N+QL + + + DL D++ G +L L+E+++G++L +
Sbjct: 25 LQAEQEDTQKKAFTCWINSQLARHTSPSVISDLFTDIKKGHVLLDLLEVLSGQQLPRDKG 84
Query: 74 SPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHF 126
S N + + N+E L F+ ++ I++ DI+DGN I+ L+ + HF
Sbjct: 85 S--NTFQCRINIEHALTFLRNRSIKLINIHVTDIIDGNPSIILGLIWTIILHF 135
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/265 (22%), Positives = 116/265 (43%), Gaps = 30/265 (11%)
Query: 232 ESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYL 291
E+ T++E K V + A + + DS +S + L +EE + ++ +L
Sbjct: 2862 ETAATEAELKHHHVTLEAS--QKELQEIDSGISTHLQE------LTNIYEELNVFERLFL 2913
Query: 292 EKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQSRLDQSMEENQ 351
E +++ K + +Q + N +E E + C E+ +Q D
Sbjct: 2914 EDQLKNLKIRTNRIQRFIQNTC---NEVEHKIKFCRQF---HEKTSALQEEADSIQRNEL 2967
Query: 352 DLKKELLK-CKQEARNLQGIKDALQQRLTQQDTSVLQLKQ--ELLRANMD---KDELHNQ 405
L +E+ K K+E NL+ A++ + Q VL+LK+ + + N D D+L Q
Sbjct: 2968 LLNQEVNKGVKEEIYNLKDRLTAIKCCILQ----VLKLKKVFDYIGLNWDFSQLDQLQTQ 3023
Query: 406 NVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQA------KLEEALRKLSDVSYHQVDLE 459
+ +++L+E+ + L +++E G+ LL + +A K+ E + K D S L
Sbjct: 3024 VFEKEKELEEKIKQLDTFEEEHGKYQALLSKMRAIDLQIKKMTEVVLKAPDSSPESRRLN 3083
Query: 460 RELEHKDVLLAHCMKREADEATNYN 484
++ + + A C+ E + N N
Sbjct: 3084 AQILSQRIEKAKCLCDEIIKKLNEN 3108
Score = 33.5 bits (75), Expect = 0.67
Identities = 33/165 (20%), Positives = 74/165 (44%), Gaps = 10/165 (6%)
Query: 282 EQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLIIIQS 341
E+L E+ + E++ E + ++ +Q LL + +P + Q ++ + ++ + +S
Sbjct: 1680 ERLKEELQVHEQKTSEFSRRVAEIQFLLQSSEIPLELQVMESSILNK-MEHVQKCLTGES 1738
Query: 342 RLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQD-----TSVLQLKQELLRAN 396
+L+++L +A+ G+ ++L + L+ D T + +++Q++L+
Sbjct: 1739 NCHALSGSTAELREDL----DQAKTQIGMTESLLKALSPSDSLEIFTKLEEIQQQILQQK 1794
Query: 397 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKL 441
L NQ L +L E + K +LQ H +KL
Sbjct: 1795 HSMILLENQIGCLTPELSELKKQYESVSDLFNTKKSVLQDHFSKL 1839
Score = 31.2 bits (69), Expect = 3.3
Identities = 67/292 (22%), Positives = 113/292 (38%), Gaps = 42/292 (14%)
Query: 277 ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQL 336
ET W EQ+ E + EK + K+ S LQ E+ E +L E+ L
Sbjct: 4809 ETFWAEQVTEVKILEEKSRQCGMKLQSLLQKW-------EEFDENYASL-------EKDL 4854
Query: 337 IIIQSRLD--QSMEENQDLKKELLKCKQE-ARNLQGIKDALQQRLTQQDTSVLQLKQELL 393
I+ S L +EE ++ E + Q+ RN+ G L Q L + V + L
Sbjct: 4855 EILISTLPSVSLVEETEERLVERISFYQQIKRNIGGKHARLYQTLNEGKQLVASVSCPEL 4914
Query: 394 RANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSY 453
+ K L Q + L +K+D L K L +R Q LE + L+
Sbjct: 4915 EGQIAK--LEEQWLSLNKKIDHELHRLQALLKHLLSYNRDSDQLTKWLESSQHTLNYWKE 4972
Query: 454 HQVDLERELE--HKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTS 511
+++ ++L+ ++ +E DE ++ T+V + G
Sbjct: 4973 QSLNVSQDLDTIRSNINNFFEFSKEVDEKSSLK------------------TAVISIGNQ 5014
Query: 512 DLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERK 563
L L +LR S + + Q T+ L + + E+LH ++ +K RK
Sbjct: 5015 LLHLKETDTATLRASLAQFE-QKWTM--LITQLPDIQEKLHQLQMEKLPSRK 5063
>gi|154277116 spectrin repeat containing, nuclear envelope 1 isoform
1 [Homo sapiens]
Length = 8797
Score = 63.5 bits (153), Expect = 6e-10
Identities = 34/119 (28%), Positives = 64/119 (53%)
Query: 9 NLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKL 68
N++ LQ+ Q + + W+N+ L KR V DL +D++DGV L L+E+++G+KL
Sbjct: 16 NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75
Query: 69 SGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
Q + N+ L+F+ +KI++ ++ DI DG ++ L+ + +F+
Sbjct: 76 PCEQGRRMKRIHAVANIGTALKFLEGRKIKLVNINSTDIADGRPSIVLGLMWTIILYFQ 134
Score = 45.1 bits (105), Expect = 2e-04
Identities = 66/290 (22%), Positives = 127/290 (43%), Gaps = 29/290 (10%)
Query: 202 VQQYEGQQRSPSE-SSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIEN---RTE 257
V + G++ + SE SS + SPSP+ A +++ + Q + A + + AE ++ +
Sbjct: 5860 VTEESGEEGTNSEISSPPACRSPSPV--ANTDASVNQ--DIAYYQALSAERLQTDAAKIH 5915
Query: 258 GTDSPLSRDWRPGSPGTY------LETSWE---EQLLEQQEYLEKEMEEAKKMISGLQAL 308
+ S + PG + L+ SWE + E+Q L + +E +K LQ++
Sbjct: 5916 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5975
Query: 309 LLNGSLPEDE-QERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNL 367
E + E P EPG +PE Q+ Q+ +D+ + ++ + +E +
Sbjct: 5976 STKMEAIELKLSESP----EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSE 6031
Query: 368 QGIKDALQQRLTQQDTSVLQLKQELLRANMD-KDELHNQNVDLQRKLDERNRLLGEYKKE 426
D +Q Q +VL + +R K +L + ++ Q + + + L Y+ E
Sbjct: 6032 SCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCE 6091
Query: 427 LGQKDRLLQQHQAKLEEAL---RKLSDVSYHQVDLER---ELEHKDVLLA 470
+ D L +A L+ AL ++ D+ +D + E+E K V L+
Sbjct: 6092 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 6141
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/187 (21%), Positives = 88/187 (47%), Gaps = 29/187 (15%)
Query: 302 ISGLQALLLNGSLPEDEQERPLAL-------CEPGVNPE-EQLIIIQSRLDQSM-EENQD 352
++ +Q + S+ +EQ++ LA CE G+ E+L + +L QS+ + +++
Sbjct: 7647 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE 7706
Query: 353 LKKELLKCKQ----------EARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK--D 400
L E ++CK+ + L +KD L ++ D S+L + ELL+ ++
Sbjct: 7707 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7766
Query: 401 ELHNQNVDLQRKLD------ERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 454
+L + + +L+ E+N+ L E+ ++ + ++ Q +EE + KL
Sbjct: 7767 QLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM--ESKVSQNGDILIEEMIEKLKKDYQE 7824
Query: 455 QVDLERE 461
++ + +E
Sbjct: 7825 EIAIAQE 7831
Score = 36.2 bits (82), Expect = 0.10
Identities = 92/443 (20%), Positives = 164/443 (37%), Gaps = 95/443 (21%)
Query: 182 QRNSSMDEEIENPYWSVRALVQQYEG-QQRSPS--------ESSCSSLTSPSPIHSAKSE 232
+ + + E +E + +V+ L+Q E +QR P + +T SP K E
Sbjct: 726 EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGK-E 784
Query: 233 SIITQSEEKADF----------------VIIPAEGIENRTE------GTDSPLSRDWRPG 270
T S+ K ++IP E +E + G + +
Sbjct: 785 MFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLERE 844
Query: 271 SPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALL-LNGSLPEDEQERPLALCEPG 329
+ + L ++LL QE +K + +K +Q + L+ L +Q R
Sbjct: 845 AQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRL------- 897
Query: 330 VNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLK 389
+ Q+ I +++ D KK + + + + + L++ VL++
Sbjct: 898 ---QRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEK--------VLRIA 946
Query: 390 QELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQQHQAKLEEALRKL 448
QE L D +EL ++ + +LD+ R+L + K + D L +Q Q L+EA+RKL
Sbjct: 947 QEGLEEKGDPEELLRRHTEFFSQLDQ--RVLNAFLKACDELTDILPEQEQQGLQEAVRKL 1004
Query: 449 --------SDVSYHQVDLERELEHKDVL--LAHCMKREADEATNYNSHNSQSNGFLLPTA 498
+ YH + L+ ++E L + C + E D T L+P
Sbjct: 1005 HKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEEC-RTELDRETK-----------LMPQE 1052
Query: 499 GKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQK 558
G ++ R FS P HH + Q I L +L V + +
Sbjct: 1053 GS----------------EKIIKEHRVFFSDKGP-HHLCEKRLQLIEELCVKLPVRDPVR 1095
Query: 559 KQER--KVRVKSPRTQVGSEYRE 579
V +K R + S YR+
Sbjct: 1096 DTPGTCHVTLKELRAAIDSTYRK 1118
Score = 33.9 bits (76), Expect = 0.51
Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 26/179 (14%)
Query: 259 TDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGL----QALLLNGSL 314
T SP ++W + T+ T + L+QQ+ LE+E+ E K ++ + + +L+ S
Sbjct: 6207 TQSPGVQEWLAQARTTW--TQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA 6264
Query: 315 PE---DEQERPLALC-EPGV-----NPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEA- 364
E D E+P L E G+ + E+Q+ + L Q Q L + +L+ +QE
Sbjct: 6265 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6324
Query: 365 ------RNLQGIKDALQQRLTQQDTSVLQLKQELLRA----NMDKDELHNQNVDLQRKL 413
R L G+ TQ ++V L L +A + Q++ L++KL
Sbjct: 6325 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKL 6383
Score = 31.2 bits (69), Expect = 3.3
Identities = 25/109 (22%), Positives = 57/109 (52%), Gaps = 5/109 (4%)
Query: 362 QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLG 421
+E++ + +A+ ++L Q TSV + + + EL + +L++ + R + L
Sbjct: 5574 EESKEIDSELEAMTEKL-QYLTSVYCTE----KMSQQVAELGRETEELRQMIKIRLQNLQ 5628
Query: 422 EYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLA 470
+ K++ + + L++ QA LE+A L+ ++ L+ +L H+ LL+
Sbjct: 5629 DAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLS 5677
Score = 30.4 bits (67), Expect = 5.7
Identities = 28/123 (22%), Positives = 54/123 (43%), Gaps = 4/123 (3%)
Query: 279 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 338
S +EQL +Q L EME K + +Q +PED L LC + +E+
Sbjct: 5664 SLKEQLSHRQHLLS-EMESLKPKVQAVQLCQSALRIPED-VVASLPLCHAALRLQEEASR 5721
Query: 339 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 398
+Q Q Q + + +QE ++LQ + + + + + + +++ L+A +
Sbjct: 5722 LQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE--LQAQIS 5779
Query: 399 KDE 401
+ E
Sbjct: 5780 RHE 5782
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/123 (30%), Positives = 67/123 (54%), Gaps = 6/123 (4%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQ-E 80
Q + + WVN+ L + + DL +DLRDG +L L+E+++GE L + + G +
Sbjct: 56 QKKTFTKWVNSHLARVSC--RITDLYKDLRDGRMLIKLLEVLSGEMLP--KPTKGKMRIH 111
Query: 81 MKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQ-GRD 139
NV+K LQF+ +++ + + DIVDGN + ++ L+ + F+ Q GR+
Sbjct: 112 CLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRE 171
Query: 140 SRA 142
+R+
Sbjct: 172 TRS 174
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/123 (30%), Positives = 67/123 (54%), Gaps = 6/123 (4%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQ-E 80
Q + + WVN+ L + + DL +DLRDG +L L+E+++GE L + + G +
Sbjct: 56 QKKTFTKWVNSHLARVSC--RITDLYKDLRDGRMLIKLLEVLSGEMLP--KPTKGKMRIH 111
Query: 81 MKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQ-GRD 139
NV+K LQF+ +++ + + DIVDGN + ++ L+ + F+ Q GR+
Sbjct: 112 CLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRE 171
Query: 140 SRA 142
+R+
Sbjct: 172 TRS 174
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 58.5 bits (140), Expect = 2e-08
Identities = 35/115 (30%), Positives = 62/115 (53%), Gaps = 5/115 (4%)
Query: 14 LQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQL 73
LQ+ Q + + WVN+ L + + DL DLRDG +L L+E+++GE+L +
Sbjct: 35 LQDEREAVQKKTFTKWVNSHLARVSC--RITDLYTDLRDGRMLIKLLEVLSGERLP--KP 90
Query: 74 SPGNQQ-EMKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
+ G + NV+K LQF+ +++ + + DIVDGN + + L+ + F+
Sbjct: 91 TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQ 145
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 58.2 bits (139), Expect = 3e-08
Identities = 33/106 (31%), Positives = 57/106 (53%), Gaps = 3/106 (2%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEM 81
Q + + WVN+ L + + DL DLRDG +L L+E+++GE+L +
Sbjct: 63 QKKTFTKWVNSHLARVGC--HIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSL 120
Query: 82 KNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
+N V+K LQF+ +++ + + DIVDGN + + LV + F+
Sbjct: 121 EN-VDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQ 165
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/138 (27%), Positives = 67/138 (48%), Gaps = 12/138 (8%)
Query: 9 NLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKL 68
N + L++ + Q + + WVN L K A + + DL +DLRDG L L+E+++G+ L
Sbjct: 9 NEISSLKDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSL 66
Query: 69 SGVQLSPGNQQEMK----NNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAA 124
P + M+ NV+ L ++ +++++ DI DGN K + L+ +
Sbjct: 67 ------PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
Query: 125 HFKPGSSRTVNQGRDSRA 142
HF+ + Q D A
Sbjct: 121 HFQISDIQVSGQSEDMTA 138
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 281 EEQLLEQQEYLEKEMEEAKKMISGL---------QALLLNGSLPEDEQERPLALCEPGVN 331
EEQ + Q+E E+E+E+ +++ G + + L + EQ+R L
Sbjct: 1658 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL------- 1710
Query: 332 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIK-----------DALQQRLTQ 380
EE+L +Q + ++ Q+L+ EL K + E L K + +QRL
Sbjct: 1711 -EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 381 QDTSVLQLKQELLRANMDKDELHNQ----NVDLQRKLDERNRLLGEYKKELGQKDRL--- 433
+ +L +E R +E Q D R+ E R+L E +G+ RL
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1829
Query: 434 ----LQQHQAKLEEALRKLSDVSYHQVDLERE-LEHK 465
L++ +A+ E R D ++ + LE + +HK
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1866
Score = 36.2 bits (82), Expect = 0.10
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 27/167 (16%)
Query: 333 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 392
+E++ ++Q+ Q + + D ++ ++ L+ K+ LQQ + +LQLK E
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAER----LREAIAELEREKEKLQQ-----EAKLLQLKSEE 2453
Query: 393 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE---------- 442
++ + L Q L E++ LL Q++R ++Q +AKLE
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLL--------QRERFIEQEKAKLEQLFQDEVAKA 2505
Query: 443 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ 489
+ LR+ Q++ ER+ + A + EA+E Q
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 276 LETSWEEQLLEQQEYLEKEMEE-AKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 334
LE + + QL ++E +E EE +K ++ + +E ER A E E
Sbjct: 1945 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2004
Query: 335 QLIIIQSRLDQSMEENQDLKKELLKCKQEARN--LQGIKDALQQRLTQQDTSVLQLKQEL 392
+ + + ++ Q+ ++ L+ +++A +Q + LQQ L Q+ + + QL+ E
Sbjct: 2005 RA---EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 393 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 448
A +E V +R+ + R + E ++ L Q Q +A+ + A KL
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL 2116
Score = 34.7 bits (78), Expect = 0.30
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 279 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 338
S E Q ++Q++ L++ + +S +LL E E+ + L + V +QL
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 339 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 398
Q R Q ME+ ++ L+ +EAR +R + + V + ++EL
Sbjct: 2511 EQQRQQQQMEQE---RQRLVASMEEAR----------RRQHEAEEGVRRKQEEL------ 2551
Query: 399 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL-QQHQAKL 441
Q ++ QR+ ++ LL E + L ++ +LL +QH+A L
Sbjct: 2552 ------QQLEQQRR--QQEELLAEENQRLREQLQLLEEQHRAAL 2587
Score = 29.6 bits (65), Expect = 9.6
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 283 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--EEQLIIIQ 340
+L Q++ + E ++ S A L ++ E E+E+ E + E++ +Q
Sbjct: 2399 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2458
Query: 341 SRLDQSMEENQDLKKELLKCK----QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 396
+Q ++E Q L++ L K Q R ++ K L+Q + QL++E R
Sbjct: 2459 Q--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-- 2514
Query: 397 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQ---HQAKLEEALRKLSDVSY 453
+ ++ + L ++E R E ++ + +K LQQ + + EE L + +
Sbjct: 2515 -QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 454 HQVDLERELEHKDVLLAH 471
Q+ L E +H+ LAH
Sbjct: 2574 EQLQLLEE-QHR-AALAH 2589
>gi|19923599 calmin [Homo sapiens]
Length = 1002
Score = 57.8 bits (138), Expect = 3e-08
Identities = 30/106 (28%), Positives = 55/106 (51%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEM 81
Q + + W+N L+K V+DL D++DG IL L+E+++G L S ++
Sbjct: 34 QKRTFTRWINLHLEKCNPPLEVKDLFVDIQDGKILMALLEVLSGRNLLHEYKSSSHRIFR 93
Query: 82 KNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
NN+ K L+F+ +++ A +I DGN ++ L+ + F+
Sbjct: 94 LNNIAKALKFLEDSNVKLVSIDAAEIADGNPSLVLGLIWNIILFFQ 139
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 57.4 bits (137), Expect = 4e-08
Identities = 33/107 (30%), Positives = 59/107 (55%), Gaps = 5/107 (4%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQ-E 80
Q + + WVN+ L + + DL DLRDG +L L+E+++GE+L + + G +
Sbjct: 56 QKKTFTKWVNSHLARVSC--RITDLYTDLRDGRMLIKLLEVLSGERLP--KPTKGRMRIH 111
Query: 81 MKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
NV+K LQF+ +++ + + DIVDGN + + L+ + F+
Sbjct: 112 CLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQ 158
>gi|23097308 spectrin repeat containing, nuclear envelope 1 isoform
2 [Homo sapiens]
Length = 8749
Score = 56.6 bits (135), Expect = 7e-08
Identities = 34/126 (26%), Positives = 64/126 (50%), Gaps = 7/126 (5%)
Query: 9 NLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKL 68
N++ LQ+ Q + + W+N+ L KR V DL +D++DGV L L+E+++G+KL
Sbjct: 16 NVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKL 75
Query: 69 SGVQLSPGNQQEMKNNVEKVLQFVASKK-------IRMHQTSAKDIVDGNLKSIMRLVLA 121
Q + N+ L+F+ +K I++ ++ DI DG ++ L+
Sbjct: 76 PCEQGRRMKRIHAVANIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWT 135
Query: 122 LAAHFK 127
+ +F+
Sbjct: 136 IILYFQ 141
Score = 45.1 bits (105), Expect = 2e-04
Identities = 66/290 (22%), Positives = 127/290 (43%), Gaps = 29/290 (10%)
Query: 202 VQQYEGQQRSPSE-SSCSSLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIEN---RTE 257
V + G++ + SE SS + SPSP+ A +++ + Q + A + + AE ++ +
Sbjct: 5789 VTEESGEEGTNSEISSPPACRSPSPV--ANTDASVNQ--DIAYYQALSAERLQTDAAKIH 5844
Query: 258 GTDSPLSRDWRPGSPGTY------LETSWE---EQLLEQQEYLEKEMEEAKKMISGLQAL 308
+ S + PG + L+ SWE + E+Q L + +E +K LQ++
Sbjct: 5845 PSTSASQEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSI 5904
Query: 309 LLNGSLPEDE-QERPLALCEPGVNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNL 367
E + E P EPG +PE Q+ Q+ +D+ + ++ + +E +
Sbjct: 5905 STKMEAIELKLSESP----EPGRSPESQMAEHQALMDEILMLQDEINELQSSLAEELVSE 5960
Query: 368 QGIKDALQQRLTQQDTSVLQLKQELLRANMD-KDELHNQNVDLQRKLDERNRLLGEYKKE 426
D +Q Q +VL + +R K +L + ++ Q + + + L Y+ E
Sbjct: 5961 SCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCE 6020
Query: 427 LGQKDRLLQQHQAKLEEAL---RKLSDVSYHQVDLER---ELEHKDVLLA 470
+ D L +A L+ AL ++ D+ +D + E+E K V L+
Sbjct: 6021 ADELDSWLLSTKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALS 6070
Score = 40.4 bits (93), Expect = 0.005
Identities = 40/187 (21%), Positives = 88/187 (47%), Gaps = 29/187 (15%)
Query: 302 ISGLQALLLNGSLPEDEQERPLAL-------CEPGVNPE-EQLIIIQSRLDQSM-EENQD 352
++ +Q + S+ +EQ++ LA CE G+ E+L + +L QS+ + +++
Sbjct: 7576 LAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEE 7635
Query: 353 LKKELLKCKQ----------EARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDK--D 400
L E ++CK+ + L +KD L ++ D S+L + ELL+ ++
Sbjct: 7636 LHAEQMRCKELENAVGSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCH 7695
Query: 401 ELHNQNVDLQRKLD------ERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 454
+L + + +L+ E+N+ L E+ ++ + ++ Q +EE + KL
Sbjct: 7696 QLSLRRQQIGERLNEWAVFSEKNKELCEWLTQM--ESKVSQNGDILIEEMIEKLKKDYQE 7753
Query: 455 QVDLERE 461
++ + +E
Sbjct: 7754 EIAIAQE 7760
Score = 36.2 bits (82), Expect = 0.10
Identities = 92/443 (20%), Positives = 164/443 (37%), Gaps = 95/443 (21%)
Query: 182 QRNSSMDEEIENPYWSVRALVQQYEG-QQRSPS--------ESSCSSLTSPSPIHSAKSE 232
+ + + E +E + +V+ L+Q E +QR P + +T SP K E
Sbjct: 733 EAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGK-E 791
Query: 233 SIITQSEEKADF----------------VIIPAEGIENRTE------GTDSPLSRDWRPG 270
T S+ K ++IP E +E + G + +
Sbjct: 792 MFATMSKLKEQLTKVKECYSPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLERE 851
Query: 271 SPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGLQALL-LNGSLPEDEQERPLALCEPG 329
+ + L ++LL QE +K + +K +Q + L+ L +Q R
Sbjct: 852 AQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFDQTRL------- 904
Query: 330 VNPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLK 389
+ Q+ I +++ D KK + + + + + L++ VL++
Sbjct: 905 ---QRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEK--------VLRIA 953
Query: 390 QELLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQ-KDRLLQQHQAKLEEALRKL 448
QE L D +EL ++ + +LD+ R+L + K + D L +Q Q L+EA+RKL
Sbjct: 954 QEGLEEKGDPEELLRRHTEFFSQLDQ--RVLNAFLKACDELTDILPEQEQQGLQEAVRKL 1011
Query: 449 --------SDVSYHQVDLERELEHKDVL--LAHCMKREADEATNYNSHNSQSNGFLLPTA 498
+ YH + L+ ++E L + C + E D T L+P
Sbjct: 1012 HKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEEC-RTELDRETK-----------LMPQE 1059
Query: 499 GKGATSVSNRGTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQK 558
G ++ R FS P HH + Q I L +L V + +
Sbjct: 1060 GS----------------EKIIKEHRVFFSDKGP-HHLCEKRLQLIEELCVKLPVRDPVR 1102
Query: 559 KQER--KVRVKSPRTQVGSEYRE 579
V +K R + S YR+
Sbjct: 1103 DTPGTCHVTLKELRAAIDSTYRK 1125
Score = 33.9 bits (76), Expect = 0.51
Identities = 45/179 (25%), Positives = 79/179 (44%), Gaps = 26/179 (14%)
Query: 259 TDSPLSRDWRPGSPGTYLETSWEEQLLEQQEYLEKEMEEAKKMISGL----QALLLNGSL 314
T SP ++W + T+ T + L+QQ+ LE+E+ E K ++ + + +L+ S
Sbjct: 6136 TQSPGVQEWLAQARTTW--TQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSA 6193
Query: 315 PE---DEQERPLALC-EPGV-----NPEEQLIIIQSRLDQSMEENQDLKKELLKCKQEA- 364
E D E+P L E G+ + E+Q+ + L Q Q L + +L+ +QE
Sbjct: 6194 AETSGDAGEKPDVLSQELGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQV 6253
Query: 365 ------RNLQGIKDALQQRLTQQDTSVLQLKQELLRA----NMDKDELHNQNVDLQRKL 413
R L G+ TQ ++V L L +A + Q++ L++KL
Sbjct: 6254 LYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGGAKRQSIHLEQKL 6312
Score = 31.2 bits (69), Expect = 3.3
Identities = 25/109 (22%), Positives = 57/109 (52%), Gaps = 5/109 (4%)
Query: 362 QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLDERNRLLG 421
+E++ + +A+ ++L Q TSV + + + EL + +L++ + R + L
Sbjct: 5503 EESKEIDSELEAMTEKL-QYLTSVYCTE----KMSQQVAELGRETEELRQMIKIRLQNLQ 5557
Query: 422 EYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEHKDVLLA 470
+ K++ + + L++ QA LE+A L+ ++ L+ +L H+ LL+
Sbjct: 5558 DAAKDMKKFEAELKKLQAALEQAQATLTSPEVGRLSLKEQLSHRQHLLS 5606
Score = 30.4 bits (67), Expect = 5.7
Identities = 28/123 (22%), Positives = 54/123 (43%), Gaps = 4/123 (3%)
Query: 279 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 338
S +EQL +Q L EME K + +Q +PED L LC + +E+
Sbjct: 5593 SLKEQLSHRQHLLS-EMESLKPKVQAVQLCQSALRIPED-VVASLPLCHAALRLQEEASR 5650
Query: 339 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 398
+Q Q Q + + +QE ++LQ + + + + + + +++ L+A +
Sbjct: 5651 LQHTAIQQCNIMQAAVVQYEQYEQEMKHLQQLIEGAHREIEDKPVATSNIQE--LQAQIS 5708
Query: 399 KDE 401
+ E
Sbjct: 5709 RHE 5711
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 7e-08
Identities = 37/132 (28%), Positives = 64/132 (48%), Gaps = 12/132 (9%)
Query: 15 QEGFNEQQLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLS 74
Q+ + Q + + WVN L K A + + DL +DLRDG L L+E+++G+ L
Sbjct: 37 QDERDRVQKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSL------ 88
Query: 75 PGNQQEMK----NNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGS 130
P + M+ NV+ L ++ +++++ DI DGN K + L+ + HF+
Sbjct: 89 PREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 148
Query: 131 SRTVNQGRDSRA 142
+ Q D A
Sbjct: 149 IQVSGQSEDMTA 160
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 281 EEQLLEQQEYLEKEMEEAKKMISGL---------QALLLNGSLPEDEQERPLALCEPGVN 331
EEQ + Q+E E+E+E+ +++ G + + L + EQ+R L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL------- 1732
Query: 332 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIK-----------DALQQRLTQ 380
EE+L +Q + ++ Q+L+ EL K + E L K + +QRL
Sbjct: 1733 -EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 381 QDTSVLQLKQELLRANMDKDELHNQ----NVDLQRKLDERNRLLGEYKKELGQKDRL--- 433
+ +L +E R +E Q D R+ E R+L E +G+ RL
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 434 ----LQQHQAKLEEALRKLSDVSYHQVDLERE-LEHK 465
L++ +A+ E R D ++ + LE + +HK
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 36.2 bits (82), Expect = 0.10
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 27/167 (16%)
Query: 333 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 392
+E++ ++Q+ Q + + D ++ ++ L+ K+ LQQ + +LQLK E
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAER----LREAIAELEREKEKLQQ-----EAKLLQLKSEE 2475
Query: 393 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE---------- 442
++ + L Q L E++ LL Q++R ++Q +AKLE
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLL--------QRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 443 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ 489
+ LR+ Q++ ER+ + A + EA+E Q
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 276 LETSWEEQLLEQQEYLEKEMEE-AKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 334
LE + + QL ++E +E EE +K ++ + +E ER A E E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 335 QLIIIQSRLDQSMEENQDLKKELLKCKQEARN--LQGIKDALQQRLTQQDTSVLQLKQEL 392
+ + + ++ Q+ ++ L+ +++A +Q + LQQ L Q+ + + QL+ E
Sbjct: 2027 RA---EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 393 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 448
A +E V +R+ + R + E ++ L Q Q +A+ + A KL
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL 2138
Score = 34.7 bits (78), Expect = 0.30
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 279 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 338
S E Q ++Q++ L++ + +S +LL E E+ + L + V +QL
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 339 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 398
Q R Q ME+ ++ L+ +EAR +R + + V + ++EL
Sbjct: 2533 EQQRQQQQMEQE---RQRLVASMEEAR----------RRQHEAEEGVRRKQEEL------ 2573
Query: 399 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL-QQHQAKL 441
Q ++ QR+ ++ LL E + L ++ +LL +QH+A L
Sbjct: 2574 ------QQLEQQRR--QQEELLAEENQRLREQLQLLEEQHRAAL 2609
Score = 29.6 bits (65), Expect = 9.6
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 283 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--EEQLIIIQ 340
+L Q++ + E ++ S A L ++ E E+E+ E + E++ +Q
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 341 SRLDQSMEENQDLKKELLKCK----QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 396
+Q ++E Q L++ L K Q R ++ K L+Q + QL++E R
Sbjct: 2481 Q--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-- 2536
Query: 397 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQ---HQAKLEEALRKLSDVSY 453
+ ++ + L ++E R E ++ + +K LQQ + + EE L + +
Sbjct: 2537 -QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 454 HQVDLERELEHKDVLLAH 471
Q+ L E +H+ LAH
Sbjct: 2596 EQLQLLEE-QHR-AALAH 2611
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/107 (33%), Positives = 57/107 (53%), Gaps = 5/107 (4%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQ-E 80
Q + + WVN+ L + V DL DLRDG L L+E+++GE L + + G +
Sbjct: 59 QKKTFTKWVNSHLAR--VTCRVGDLYSDLRDGRNLLRLLEVLSGEILP--KPTKGRMRIH 114
Query: 81 MKNNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFK 127
NV+K LQF+ +K+ + + DIVDGN + + LV + F+
Sbjct: 115 CLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQ 161
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 56.2 bits (134), Expect = 1e-07
Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 15/138 (10%)
Query: 12 DVLQEGFNEQ---QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKL 68
DVL+ +E+ Q + + W+N L K K V DL +DLRDG L L+E+++G+ L
Sbjct: 24 DVLERYKDERDKVQKKTFTKWINQHLMK--VRKHVNDLYEDLRDGHNLISLLEVLSGDTL 81
Query: 69 SGVQLSPGNQQEMK----NNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAA 124
P + M+ NV+ L ++ +++++ DI DGN K + L+ +
Sbjct: 82 ------PREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 135
Query: 125 HFKPGSSRTVNQGRDSRA 142
HF+ + D A
Sbjct: 136 HFQISDIHVTGESEDMSA 153
Score = 35.4 bits (80), Expect = 0.18
Identities = 49/234 (20%), Positives = 100/234 (42%), Gaps = 26/234 (11%)
Query: 276 LETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEP-GVNPEE 334
L +W++++ + LE+ M+ A + GLQA+ + + LA P G + E
Sbjct: 4165 LNKAWKDRI----DKLEEAMQAAVQYQDGLQAVFDWVDIAGGK----LASMSPIGTDLET 4216
Query: 335 QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLR 394
+ Q +EE + K E + + E L + L +++T++ ++ L+
Sbjct: 4217 --------VKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHT-VQDPLME 4267
Query: 395 ANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYH 454
+ D L + ++ Q KL+ LG+++ L + L + L E D
Sbjct: 4268 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327
Query: 455 QVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNR 508
+++L + ++ +LAH EA N N + +AG+ A+++ N+
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEA--------VNKAGNDLIESSAGEEASNLQNK 4373
Score = 34.3 bits (77), Expect = 0.39
Identities = 34/132 (25%), Positives = 60/132 (45%), Gaps = 9/132 (6%)
Query: 347 MEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQ-DT-SVLQLKQELLRANMDKDELHN 404
+E+N+ + EL KQ +Q +KD L + L + DT + KQ L + EL+
Sbjct: 2469 VEQNKSFEAEL---KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQ 2525
Query: 405 QNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERELEH 464
+D Q+KL+E + L +++ Q L+Q + E + L +S L + +
Sbjct: 2526 LTIDRQQKLEESSNNLTQFQTVEAQ----LKQWLVEKELMVSVLGPLSIDPNMLNTQRQQ 2581
Query: 465 KDVLLAHCMKRE 476
+LL R+
Sbjct: 2582 VQILLQEFATRK 2593
Score = 31.6 bits (70), Expect = 2.5
Identities = 47/222 (21%), Positives = 96/222 (43%), Gaps = 14/222 (6%)
Query: 343 LDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANM-DKDE 401
++Q ++EN + K+ L+ +KDA+Q++ + +S + ++L++ +M +K+E
Sbjct: 797 VEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 856
Query: 402 LHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDVSYHQVDLERE 461
L LQ K N L+G+ K + K R L+ ++ + Y Q+++
Sbjct: 857 L------LQYKSTIAN-LMGKAKTIIQLKPR---NSDCPLKTSIPIKAICDYRQIEITIY 906
Query: 462 LEHKDVLL--AHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNRGTSDLQLVRDA 519
+ + VL +H K + T N S F +P K A ++NR Q V
Sbjct: 907 KDDECVLANNSHRAKWKVISPTG-NEAMVPSVCFTVPPPNKEAVDLANRIEQQYQNVLTL 965
Query: 520 LRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQE 561
+ H+ I+ +++ +S + + M + Q+
Sbjct: 966 WHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQ 1007
Score = 30.0 bits (66), Expect = 7.4
Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 15/129 (11%)
Query: 343 LDQSMEENQDLKKELLKCKQEARNLQ-----------GIKDALQQRLTQQDTSVLQLKQE 391
L Q EE++ L++ + + K + G ++Q++ DT Q+K++
Sbjct: 3887 LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKED 3946
Query: 392 LLRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSDV 451
+ + + DE +Q+ K+D+ L + L Q + A++E+ ++S+
Sbjct: 3947 VKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSI----SAEVEKIKEQISEN 4002
Query: 452 SYHQVDLER 460
VD+E+
Sbjct: 4003 KNVSVDMEK 4011
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 56.2 bits (134), Expect = 1e-07
Identities = 36/125 (28%), Positives = 61/125 (48%), Gaps = 12/125 (9%)
Query: 22 QLQAYVAWVNAQLKKRPAVKPVQDLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEM 81
Q + + WVN L K A + + DL +DLRDG L L+E+++G+ L P + M
Sbjct: 44 QKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSL------PREKGRM 95
Query: 82 K----NNVEKVLQFVASKKIRMHQTSAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQG 137
+ NV+ L ++ +++++ DI DGN K + L+ + HF+ + Q
Sbjct: 96 RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 155
Query: 138 RDSRA 142
D A
Sbjct: 156 EDMTA 160
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 40/217 (18%)
Query: 281 EEQLLEQQEYLEKEMEEAKKMISGL---------QALLLNGSLPEDEQERPLALCEPGVN 331
EEQ + Q+E E+E+E+ +++ G + + L + EQ+R L
Sbjct: 1680 EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL------- 1732
Query: 332 PEEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIK-----------DALQQRLTQ 380
EE+L +Q + ++ Q+L+ EL K + E L K + +QRL
Sbjct: 1733 -EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 381 QDTSVLQLKQELLRANMDKDELHNQ----NVDLQRKLDERNRLLGEYKKELGQKDRL--- 433
+ +L +E R +E Q D R+ E R+L E +G+ RL
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 434 ----LQQHQAKLEEALRKLSDVSYHQVDLERE-LEHK 465
L++ +A+ E R D ++ + LE + +HK
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHK 1888
Score = 36.2 bits (82), Expect = 0.10
Identities = 37/167 (22%), Positives = 71/167 (42%), Gaps = 27/167 (16%)
Query: 333 EEQLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL 392
+E++ ++Q+ Q + + D ++ ++ L+ K+ LQQ + +LQLK E
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAER----LREAIAELEREKEKLQQ-----EAKLLQLKSEE 2475
Query: 393 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLE---------- 442
++ + L Q L E++ LL Q++R ++Q +AKLE
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLL--------QRERFIEQEKAKLEQLFQDEVAKA 2527
Query: 443 EALRKLSDVSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQ 489
+ LR+ Q++ ER+ + A + EA+E Q
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/176 (22%), Positives = 78/176 (44%), Gaps = 7/176 (3%)
Query: 276 LETSWEEQLLEQQEYLEKEMEE-AKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE 334
LE + + QL ++E +E EE +K ++ + +E ER A E E
Sbjct: 1967 LEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE 2026
Query: 335 QLIIIQSRLDQSMEENQDLKKELLKCKQEARN--LQGIKDALQQRLTQQDTSVLQLKQEL 392
+ + + ++ Q+ ++ L+ +++A +Q + LQQ L Q+ + + QL+ E
Sbjct: 2027 RA---EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 393 LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKL 448
A +E V +R+ + R + E ++ L Q Q +A+ + A KL
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAER-LKQSAEEQAQARAQAQAAAEKL 2138
Score = 34.7 bits (78), Expect = 0.30
Identities = 40/164 (24%), Positives = 75/164 (45%), Gaps = 28/164 (17%)
Query: 279 SWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEEQLII 338
S E Q ++Q++ L++ + +S +LL E E+ + L + V +QL
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 339 IQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMD 398
Q R Q ME+ ++ L+ +EAR +R + + V + ++EL
Sbjct: 2533 EQQRQQQQMEQE---RQRLVASMEEAR----------RRQHEAEEGVRRKQEEL------ 2573
Query: 399 KDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLL-QQHQAKL 441
Q ++ QR+ ++ LL E + L ++ +LL +QH+A L
Sbjct: 2574 ------QQLEQQRR--QQEELLAEENQRLREQLQLLEEQHRAAL 2609
Score = 29.6 bits (65), Expect = 9.6
Identities = 45/198 (22%), Positives = 87/198 (43%), Gaps = 16/198 (8%)
Query: 283 QLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNP--EEQLIIIQ 340
+L Q++ + E ++ S A L ++ E E+E+ E + E++ +Q
Sbjct: 2421 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQ 2480
Query: 341 SRLDQSMEENQDLKKELLKCK----QEARNLQGIKDALQQRLTQQDTSVLQLKQELLRAN 396
+Q ++E Q L++ L K Q R ++ K L+Q + QL++E R
Sbjct: 2481 Q--EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR-- 2536
Query: 397 MDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQ---HQAKLEEALRKLSDVSY 453
+ ++ + L ++E R E ++ + +K LQQ + + EE L + +
Sbjct: 2537 -QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 454 HQVDLERELEHKDVLLAH 471
Q+ L E +H+ LAH
Sbjct: 2596 EQLQLLEE-QHR-AALAH 2611
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,093,256
Number of Sequences: 37866
Number of extensions: 1201949
Number of successful extensions: 7917
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 684
Number of HSP's that attempted gapping in prelim test: 4923
Number of HSP's gapped (non-prelim): 2741
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.