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Search of human proteins with 78499633
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78499633 phospholipase C, eta 2 [Homo sapiens]
(1416 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 2871 0.0
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 1214 0.0
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 1211 0.0
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 1211 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 380 e-105
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 380 e-105
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 350 6e-96
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 350 6e-96
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 348 2e-95
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 348 2e-95
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 345 1e-94
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 318 2e-86
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 318 2e-86
gi|11386139 phospholipase C beta 3 [Homo sapiens] 313 6e-85
gi|19115964 phospholipase C delta 3 [Homo sapiens] 305 3e-82
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 303 6e-82
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 303 1e-81
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 298 2e-80
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 284 4e-76
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 245 2e-64
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 244 6e-64
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 244 6e-64
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 231 3e-60
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 58 7e-08
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 58 7e-08
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 57 1e-07
gi|91208420 bassoon protein [Homo sapiens] 56 3e-07
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 54 1e-06
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens] 54 1e-06
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens] 54 1e-06
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 2871 bits (7443), Expect = 0.0
Identities = 1416/1416 (100%), Positives = 1416/1416 (100%)
Query: 1 MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRG 60
MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRG
Sbjct: 1 MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRG 60
Query: 61 GSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNC 120
GSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNC
Sbjct: 61 GSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNC 120
Query: 121 CFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDE 180
CFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDE
Sbjct: 121 CFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDE 180
Query: 181 ADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMST 240
ADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMST
Sbjct: 181 ADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMST 240
Query: 241 RRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLL 300
RRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLL
Sbjct: 241 RRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLL 300
Query: 301 GIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYA 360
GIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYA
Sbjct: 301 GIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYA 360
Query: 361 WVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE 420
WVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE
Sbjct: 361 WVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE 420
Query: 421 NHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISED 480
NHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISED
Sbjct: 421 NHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISED 480
Query: 481 AEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFS 540
AEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFS
Sbjct: 481 AEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFS 540
Query: 541 VSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGD 600
VSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGD
Sbjct: 541 VSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGD 600
Query: 601 EGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAH 660
EGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAH
Sbjct: 601 EGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAH 660
Query: 661 QILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLN 720
QILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLN
Sbjct: 661 QILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLN 720
Query: 721 RAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGD 780
RAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGD
Sbjct: 721 RAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGD 780
Query: 781 RGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDH 840
RGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDH
Sbjct: 781 RGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDH 840
Query: 841 DPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLR 900
DPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLR
Sbjct: 841 DPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLR 900
Query: 901 GPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVA 960
GPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVA
Sbjct: 901 GPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVA 960
Query: 961 DDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA 1020
DDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA
Sbjct: 961 DDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA 1020
Query: 1021 AVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS 1080
AVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS
Sbjct: 1021 AVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS 1080
Query: 1081 QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHR 1140
QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHR
Sbjct: 1081 QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHR 1140
Query: 1141 DSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKS 1200
DSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKS
Sbjct: 1141 DSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKS 1200
Query: 1201 KSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDL 1260
KSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDL
Sbjct: 1201 KSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDL 1260
Query: 1261 TADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS 1320
TADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS
Sbjct: 1261 TADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS 1320
Query: 1321 LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPE 1380
LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPE
Sbjct: 1321 LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPE 1380
Query: 1381 GACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL 1416
GACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL
Sbjct: 1381 GACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL 1416
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 1214 bits (3141), Expect = 0.0
Identities = 595/920 (64%), Positives = 737/920 (80%), Gaps = 10/920 (1%)
Query: 46 MGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQS 105
M MQ G QM+KL+ G+KGLVR +YLDEHR+ +RWRPSRK+EKAKI IDSI +V+EGRQS
Sbjct: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
Query: 106 EVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLAR 165
E+F R +G+FDP+CCF+IYHG+H ESLDL++++ E ARTW+TGL+YLMAGISDEDSLA+
Sbjct: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
Query: 166 RQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGT 225
RQRT DQW+KQTF+EADKNGDG L+I E+ QL+HKLNVNLPR++V+QMF+EADTD++QGT
Sbjct: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
Query: 226 LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDII 285
L FEEFC FYKMMS RRDLYLL+L+YS+ KDHL L +FL+VEQKM VT + C DII
Sbjct: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
Query: 286 EQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYL 345
++FE ENK K +LGI+GFTN+ RSPA DIFNP HH V+QDM QPL +Y+I SSHNTYL
Sbjct: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
Query: 346 VGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINK 405
GDQL+SQS+VDMYA VLQ GCRCVEVDCWDGPDGEP+VHHGYTLTSKILF+DV+ETINK
Sbjct: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
Query: 406 YAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGK 465
+AF+KNE+PVILSIENHCS+ QQ+K+AQYL I GDKLDLSSV + + LPSPQ LKGK
Sbjct: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
Query: 466 ILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKL-LNGDASTNRKRVENTAKRKLDSL 524
ILVKGKKLP ++ +DAEEGEVSDEDSADEI+D+CK L+ T +VE+ ++KL+SL
Sbjct: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
Query: 525 IKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRK 584
+KES+IRD EDP++F+V L + G + ++ + E + +GR ++ +F + K
Sbjct: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKE--SGKKSHGRSLMTNFGKHK 538
Query: 585 KKGSKLKKAASVEEGDEGQDS---PGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDI 641
K K+ S ++ ++ Q S GGQ R++KTMKL R LSDLV YT SVA DI
Sbjct: 539 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI 598
Query: 642 EMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNA 701
++ ++ V SFSET+AHQ++QQK Q++ +NQ+QL+RIYPS+YR+DSSN+NP P+WNA
Sbjct: 599 -VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNA 657
Query: 702 GCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLV 761
GCQ+VALNYQSEGRM+QLNRAKF ANG CGYVLKP MC+G FNP S DPLP KKQL+
Sbjct: 658 GCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLI 717
Query: 762 LRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETL 821
L++ISGQQLPKP DSM GDRGEIIDPFVEVEIIGLPVDC ++QTRVVDDNGFNP WEETL
Sbjct: 718 LKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETL 777
Query: 822 VFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAV 881
F VHMPEIALVRFLVWDHDPIGRDF+GQRT+ FSS++PGYRHVYLEG+ EASIFVH+ +
Sbjct: 778 TFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITI 837
Query: 882 SDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGR 941
++I GK +Q GLKGLF + P+ S ++++ + S+ RILRRTASAP K +K +
Sbjct: 838 NEIYGKNRQLQGLKGLFNKNPRHSSSENNS--HYVRKRSIGDRILRRTASAPAKGRKKSK 895
Query: 942 RGFPELVLGTRDTGSKGVAD 961
GF E+V +D+ S+ D
Sbjct: 896 MGFQEMV-EIKDSVSEATRD 914
Score = 67.4 bits (163), Expect = 9e-11
Identities = 64/184 (34%), Positives = 80/184 (43%), Gaps = 44/184 (23%)
Query: 1249 PVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRR------DTLTEQ 1302
P KSKSLGDLT++D A +FE + +S S + G R G V+ D LTEQ
Sbjct: 1449 PSPCKSKSLGDLTSEDIACNFESKYQCISKSF-VTTGIRDKKGVTVKTKSLEPIDALTEQ 1507
Query: 1303 LRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQR 1362
LR L F Q + S A + VR+ SSRS SRVR IASRA++ QE ++
Sbjct: 1508 LRKLVSFDQEDNCQVLYSKQDANQLPRA---LVRKLSSRSQSRVRNIASRAKEKQEANKQ 1564
Query: 1363 -----LQGLG-----------------------------RQGPPEEERGTPEGACSVGHE 1388
G G +G E RG PEGAC+ H
Sbjct: 1565 KVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHY 1624
Query: 1389 GSVD 1392
G VD
Sbjct: 1625 GHVD 1628
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 1211 bits (3133), Expect = 0.0
Identities = 599/944 (63%), Positives = 741/944 (78%), Gaps = 30/944 (3%)
Query: 42 VERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSE 101
VERCM MQ G QM+KL+ G+KGLVR +YLDEHR+ +RWRPSRK+EKAKI IDSI +V+E
Sbjct: 15 VERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTE 74
Query: 102 GRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDED 161
GRQSE+F R +G+FDP+CCF+IYHG+H ESLDL++++ E ARTW+TGL+YLMAGISDED
Sbjct: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
Query: 162 SLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDD 221
SLA+RQRT DQW+KQTF+EADKNGDG L+I E+ QL+HKLNVNLPR++V+QMF+EADTD+
Sbjct: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
Query: 222 HQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESC 281
+QGTL FEEFC FYKMMS RRDLYLL+L+YS+ KDHL L +FL+VEQKM VT + C
Sbjct: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
Query: 282 QDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSH 341
DII++FE ENK K +LGI+GFTN+ RSPA DIFNP HH V+QDM QPL +Y+I SSH
Sbjct: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
Query: 342 NTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIE 401
NTYL GDQL+SQS+VDMYA VLQ GCRCVEVDCWDGPDGEP+VHHGYTLTSKILF+DV+E
Sbjct: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
Query: 402 TINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQM 461
TINK+AF+KNE+PVILSIENHCS+ QQ+K+AQYL I GDKLDLSSV + + LPSPQ
Sbjct: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
Query: 462 LKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKL-LNGDASTNRKRVENTAKRK 520
LKGKILVKGKKLP ++ +DAEEGEVSDEDSADEI+D+CK L+ T +VE+ ++K
Sbjct: 435 LKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKK 494
Query: 521 LDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSF 580
L+SL+KES+IRD EDP++F+V L + G + ++ + E + +GR ++ +F
Sbjct: 495 LESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKE--SGKKSHGRSLMTNF 552
Query: 581 SRRKKKGSKLKKAASVEEGDEGQDS---PGGQSRGATRQKKTMKLSRALSDLVKYTKSVA 637
+ KK K+ S ++ ++ Q S GGQ R++KTMKL R LSDLV YT SVA
Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVA 612
Query: 638 THDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQP 697
DI ++ ++ V SFSET+AHQ++QQK Q++ +NQ+QL+RIYPS+YR+DSSN+NP P
Sbjct: 613 AQDI-VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671
Query: 698 FWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLK 757
+WNAGCQ+VALNYQSEGRM+QLNRAKF ANG CGYVLKP MC+G FNP S DPLP K
Sbjct: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPK 731
Query: 758 KQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTW 817
KQL+L++ISGQQLPKP DSM GDRGEIIDPFVEVEIIGLPVDC ++QTRVVDDNGFNP W
Sbjct: 732 KQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVW 791
Query: 818 EETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFV 877
EETL F VHMPEIALVRFLVWDHDPIGRDF+GQRT+ FSS++PGYRHVYLEG+ EASIFV
Sbjct: 792 EETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFV 851
Query: 878 HVAVSDISG--------------------KVKQALGLKGLFLRGPKPGSLDSHAAGRPPA 917
H+ +++I G K +Q GLKGLF + P+ S ++++
Sbjct: 852 HITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNS--HYVR 909
Query: 918 RPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVAD 961
+ S+ RILRRTASAP K +K + GF E+V +D+ S+ D
Sbjct: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMV-EIKDSVSEATRD 952
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 1211 bits (3133), Expect = 0.0
Identities = 599/944 (63%), Positives = 741/944 (78%), Gaps = 30/944 (3%)
Query: 42 VERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSE 101
VERCM MQ G QM+KL+ G+KGLVR +YLDEHR+ +RWRPSRK+EKAKI IDSI +V+E
Sbjct: 15 VERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTE 74
Query: 102 GRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDED 161
GRQSE+F R +G+FDP+CCF+IYHG+H ESLDL++++ E ARTW+TGL+YLMAGISDED
Sbjct: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
Query: 162 SLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDD 221
SLA+RQRT DQW+KQTF+EADKNGDG L+I E+ QL+HKLNVNLPR++V+QMF+EADTD+
Sbjct: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
Query: 222 HQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESC 281
+QGTL FEEFC FYKMMS RRDLYLL+L+YS+ KDHL L +FL+VEQKM VT + C
Sbjct: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
Query: 282 QDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSH 341
DII++FE ENK K +LGI+GFTN+ RSPA DIFNP HH V+QDM QPL +Y+I SSH
Sbjct: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
Query: 342 NTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIE 401
NTYL GDQL+SQS+VDMYA VLQ GCRCVEVDCWDGPDGEP+VHHGYTLTSKILF+DV+E
Sbjct: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
Query: 402 TINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQM 461
TINK+AF+KNE+PVILSIENHCS+ QQ+K+AQYL I GDKLDLSSV + + LPSPQ
Sbjct: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
Query: 462 LKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKL-LNGDASTNRKRVENTAKRK 520
LKGKILVKGKKLP ++ +DAEEGEVSDEDSADEI+D+CK L+ T +VE+ ++K
Sbjct: 435 LKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKK 494
Query: 521 LDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSF 580
L+SL+KES+IRD EDP++F+V L + G + ++ + E + +GR ++ +F
Sbjct: 495 LESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKE--SGKKSHGRSLMTNF 552
Query: 581 SRRKKKGSKLKKAASVEEGDEGQDS---PGGQSRGATRQKKTMKLSRALSDLVKYTKSVA 637
+ KK K+ S ++ ++ Q S GGQ R++KTMKL R LSDLV YT SVA
Sbjct: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVA 612
Query: 638 THDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQP 697
DI ++ ++ V SFSET+AHQ++QQK Q++ +NQ+QL+RIYPS+YR+DSSN+NP P
Sbjct: 613 AQDI-VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671
Query: 698 FWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLK 757
+WNAGCQ+VALNYQSEGRM+QLNRAKF ANG CGYVLKP MC+G FNP S DPLP K
Sbjct: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPK 731
Query: 758 KQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTW 817
KQL+L++ISGQQLPKP DSM GDRGEIIDPFVEVEIIGLPVDC ++QTRVVDDNGFNP W
Sbjct: 732 KQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVW 791
Query: 818 EETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFV 877
EETL F VHMPEIALVRFLVWDHDPIGRDF+GQRT+ FSS++PGYRHVYLEG+ EASIFV
Sbjct: 792 EETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFV 851
Query: 878 HVAVSDISG--------------------KVKQALGLKGLFLRGPKPGSLDSHAAGRPPA 917
H+ +++I G K +Q GLKGLF + P+ S ++++
Sbjct: 852 HITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNS--HYVR 909
Query: 918 RPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVAD 961
+ S+ RILRRTASAP K +K + GF E+V +D+ S+ D
Sbjct: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMV-EIKDSVSEATRD 952
Score = 67.4 bits (163), Expect = 9e-11
Identities = 64/184 (34%), Positives = 80/184 (43%), Gaps = 44/184 (23%)
Query: 1249 PVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRR------DTLTEQ 1302
P KSKSLGDLT++D A +FE + +S S + G R G V+ D LTEQ
Sbjct: 1487 PSPCKSKSLGDLTSEDIACNFESKYQCISKSF-VTTGIRDKKGVTVKTKSLEPIDALTEQ 1545
Query: 1303 LRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQR 1362
LR L F Q + S A + VR+ SSRS SRVR IASRA++ QE ++
Sbjct: 1546 LRKLVSFDQEDNCQVLYSKQDANQLPRA---LVRKLSSRSQSRVRNIASRAKEKQEANKQ 1602
Query: 1363 -----LQGLG-----------------------------RQGPPEEERGTPEGACSVGHE 1388
G G +G E RG PEGAC+ H
Sbjct: 1603 KVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHY 1662
Query: 1389 GSVD 1392
G VD
Sbjct: 1663 GHVD 1666
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 380 bits (976), Expect = e-105
Identities = 204/457 (44%), Positives = 291/457 (63%), Gaps = 9/457 (1%)
Query: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103
C+ +M EG ++ K+R S+ R++ LD +RW PS+K+ EKAKI I SI+EV G+
Sbjct: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198
Query: 104 QSEVFQRYP-DGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA-GISDED 161
+++F+ +C FS+ +G + ESLDLV+ S++VA WVTGLRYL++ G D
Sbjct: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
Query: 162 SLARRQ-RTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD-T 219
L Q R W+ Q F E D + G +++ +Q + LN L +++ F+E +
Sbjct: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318
Query: 220 DDHQGT-LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTL 278
D GT + EEF + + TR ++Y L++ +S++K+ LD L FL+ EQ +A +
Sbjct: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378
Query: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338
E +II ++EP E + KG L IDGFTNY SP IF+PEH V QDM QPLSHYFI
Sbjct: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438
Query: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKD 398
SSHNTYL+ DQ S + Y L+ GCR VE+D WDGPD EP+++ G+T+TS+I+F+
Sbjct: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498
Query: 399 VIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPS 458
VI+ INKYAF +EYP+IL +ENHCS+ QQK M Q++ +LGDKL +S + E+ + LPS
Sbjct: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557
Query: 459 PQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEI 495
P +LKGKIL+K KKL +N S EG+V+DED E+
Sbjct: 558 PDVLKGKILIKAKKLSSNCS--GVEGDVTDEDEGAEM 592
Score = 241 bits (616), Expect = 3e-63
Identities = 129/320 (40%), Positives = 193/320 (60%), Gaps = 21/320 (6%)
Query: 586 KGSKLKKAASVEEGDEGQDSPGG---QSRGATRQK-------KTMKLSRALSDLVKYTKS 635
K KL S EGD + G Q G + K +L + LS+LV KS
Sbjct: 568 KAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKS 627
Query: 636 VATHDIEM--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNY 693
V + ++ + W+V SF+E A + + P ++ +N++ L+R++PS R+DSSN
Sbjct: 628 VQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNM 687
Query: 694 NPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDP 751
NPQ FW GCQ+VA+N+Q+ G M+ LN F NG CGYVL+P M + V F+ N++D
Sbjct: 688 NPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDS 747
Query: 752 LPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDN 811
+PG + L ++IISGQ PKP+ S G +G+++DP+V VEI G+P DC+ ++T+ V N
Sbjct: 748 VPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQN 805
Query: 812 GFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL---- 867
G P ++E+ F +++PE+A+VRF+V D D IG +FIGQ T+ F + GYRHV L
Sbjct: 806 GDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLT 865
Query: 868 -EGMEEASIFVHVAVSDISG 886
E + AS+FVHVA+++ G
Sbjct: 866 GEVLAHASLFVHVAITNRRG 885
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 380 bits (976), Expect = e-105
Identities = 204/457 (44%), Positives = 291/457 (63%), Gaps = 9/457 (1%)
Query: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103
C+ +M EG ++ K+R S+ R++ LD +RW PS+K+ EKAKI I SI+EV G+
Sbjct: 13 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 72
Query: 104 QSEVFQRYP-DGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMA-GISDED 161
+++F+ +C FS+ +G + ESLDLV+ S++VA WVTGLRYL++ G D
Sbjct: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
Query: 162 SLARRQ-RTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD-T 219
L Q R W+ Q F E D + G +++ +Q + LN L +++ F+E +
Sbjct: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 192
Query: 220 DDHQGT-LGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTL 278
D GT + EEF + + TR ++Y L++ +S++K+ LD L FL+ EQ +A +
Sbjct: 193 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 252
Query: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338
E +II ++EP E + KG L IDGFTNY SP IF+PEH V QDM QPLSHYFI
Sbjct: 253 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 312
Query: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKD 398
SSHNTYL+ DQ S + Y L+ GCR VE+D WDGPD EP+++ G+T+TS+I+F+
Sbjct: 313 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 372
Query: 399 VIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPS 458
VI+ INKYAF +EYP+IL +ENHCS+ QQK M Q++ +LGDKL +S + E+ + LPS
Sbjct: 373 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 431
Query: 459 PQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEI 495
P +LKGKIL+K KKL +N S EG+V+DED E+
Sbjct: 432 PDVLKGKILIKAKKLSSNCS--GVEGDVTDEDEGAEM 466
Score = 241 bits (616), Expect = 3e-63
Identities = 129/320 (40%), Positives = 193/320 (60%), Gaps = 21/320 (6%)
Query: 586 KGSKLKKAASVEEGDEGQDSPGG---QSRGATRQK-------KTMKLSRALSDLVKYTKS 635
K KL S EGD + G Q G + K +L + LS+LV KS
Sbjct: 442 KAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKENMEQPNNVPVKRFQLCKELSELVSICKS 501
Query: 636 VATHDIEM--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNY 693
V + ++ + W+V SF+E A + + P ++ +N++ L+R++PS R+DSSN
Sbjct: 502 VQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPMRIDSSNM 561
Query: 694 NPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDP 751
NPQ FW GCQ+VA+N+Q+ G M+ LN F NG CGYVL+P M + V F+ N++D
Sbjct: 562 NPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFFSANTKDS 621
Query: 752 LPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDN 811
+PG + L ++IISGQ PKP+ S G +G+++DP+V VEI G+P DC+ ++T+ V N
Sbjct: 622 VPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQRTKTVHQN 679
Query: 812 GFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL---- 867
G P ++E+ F +++PE+A+VRF+V D D IG +FIGQ T+ F + GYRHV L
Sbjct: 680 GDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRHVPLQSLT 739
Query: 868 -EGMEEASIFVHVAVSDISG 886
E + AS+FVHVA+++ G
Sbjct: 740 GEVLAHASLFVHVAITNRRG 759
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 350 bits (898), Expect = 6e-96
Identities = 202/499 (40%), Positives = 299/499 (59%), Gaps = 17/499 (3%)
Query: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103
C+ MQ G ++ K+R S+ RF+ LD +RW PS+K+ EKAK+ I +I+E+ G+
Sbjct: 111 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 170
Query: 104 QSEVFQRYPDGSFDP---NCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDE 160
+E F+ +G D +C FSI HG + ESLDLV+ S++VA WV+GLRYL++
Sbjct: 171 NTETFRN--NGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQP 228
Query: 161 -DSLARRQRT-RDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD 218
D + Q T R WLK F+ AD +G+G + ++L+ +LN L +++ F+E
Sbjct: 229 LDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQ 288
Query: 219 TDDHQGTLGF--EEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGV 276
+ T EEFC + + TR ++Y L++ S +K++LDA L FL+ EQ + +
Sbjct: 289 KSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHI 348
Query: 277 TLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYF 336
T + C DII ++E E + KG L IDGFT Y S DIF+PE V QDMTQPLSHY+
Sbjct: 349 TEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYY 408
Query: 337 ITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILF 396
I +SHNTYL+ DQ + ++ Y L+ GCR VE+D DG D EPI+ + +T+ + F
Sbjct: 409 INASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSF 468
Query: 397 KDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTL 456
+ VIE INK+AF+ +EYP+IL + NHCS+ QQK MAQ + + G+KL + + L
Sbjct: 469 RSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKL-YTEAPLPSESYL 527
Query: 457 PSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENT 516
PSP+ LK I+VKGKKLP++ D EGEV+DED E+ + ++ D + +K++
Sbjct: 528 PSPEKLKRMIIVKGKKLPSD--PDVLEGEVTDEDEEAEMS---RRMSVDYNGEQKQIRLC 582
Query: 517 AK-RKLDSLIKESKIRDCE 534
+ L S+ K + RD E
Sbjct: 583 RELSDLVSICKSVQYRDFE 601
Score = 264 bits (675), Expect = 4e-70
Identities = 140/315 (44%), Positives = 200/315 (63%), Gaps = 16/315 (5%)
Query: 586 KGSKLKKAASVEEG-----DEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHD 640
KG KL V EG DE + S ++K ++L R LSDLV KSV D
Sbjct: 540 KGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRD 599
Query: 641 IE--MEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPF 698
E M++ + W++ SFSET+A +I + P ++ +N++ LSRIYPS+ R+DSSN NPQ F
Sbjct: 600 FELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDF 659
Query: 699 WNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDPLPGQL 756
WN GCQ+VA+N+Q+ G M+ L+ F NGGCGYVL+P M V F+ N++ LPG
Sbjct: 660 WNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVS 719
Query: 757 KKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPT 816
L ++IISGQ PKP+ + +G++IDP+V +EI G+P DCS ++T+ V N NP
Sbjct: 720 PLALHIKIISGQNFPKPKGACA--KGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPI 777
Query: 817 WEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEG-----ME 871
++ET F V++PE+A++RF+V D D IG +FIGQ T+ F + PGYRHV L ME
Sbjct: 778 FDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIME 837
Query: 872 EASIFVHVAVSDISG 886
++FVH+A+++ SG
Sbjct: 838 HVTLFVHIAITNRSG 852
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 350 bits (898), Expect = 6e-96
Identities = 202/499 (40%), Positives = 299/499 (59%), Gaps = 17/499 (3%)
Query: 45 CMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKN-EKAKISIDSIQEVSEGR 103
C+ MQ G ++ K+R S+ RF+ LD +RW PS+K+ EKAK+ I +I+E+ G+
Sbjct: 13 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 72
Query: 104 QSEVFQRYPDGSFDP---NCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDE 160
+E F+ +G D +C FSI HG + ESLDLV+ S++VA WV+GLRYL++
Sbjct: 73 NTETFRN--NGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQP 130
Query: 161 -DSLARRQRT-RDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREAD 218
D + Q T R WLK F+ AD +G+G + ++L+ +LN L +++ F+E
Sbjct: 131 LDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQ 190
Query: 219 TDDHQGTLGF--EEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGV 276
+ T EEFC + + TR ++Y L++ S +K++LDA L FL+ EQ + +
Sbjct: 191 KSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHI 250
Query: 277 TLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYF 336
T + C DII ++E E + KG L IDGFT Y S DIF+PE V QDMTQPLSHY+
Sbjct: 251 TEDICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYY 310
Query: 337 ITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILF 396
I +SHNTYL+ DQ + ++ Y L+ GCR VE+D DG D EPI+ + +T+ + F
Sbjct: 311 INASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSF 370
Query: 397 KDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTL 456
+ VIE INK+AF+ +EYP+IL + NHCS+ QQK MAQ + + G+KL + + L
Sbjct: 371 RSVIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKL-YTEAPLPSESYL 429
Query: 457 PSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENT 516
PSP+ LK I+VKGKKLP++ D EGEV+DED E+ + ++ D + +K++
Sbjct: 430 PSPEKLKRMIIVKGKKLPSD--PDVLEGEVTDEDEEAEMS---RRMSVDYNGEQKQIRLC 484
Query: 517 AK-RKLDSLIKESKIRDCE 534
+ L S+ K + RD E
Sbjct: 485 RELSDLVSICKSVQYRDFE 503
Score = 264 bits (675), Expect = 4e-70
Identities = 140/315 (44%), Positives = 200/315 (63%), Gaps = 16/315 (5%)
Query: 586 KGSKLKKAASVEEG-----DEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHD 640
KG KL V EG DE + S ++K ++L R LSDLV KSV D
Sbjct: 442 KGKKLPSDPDVLEGEVTDEDEEAEMSRRMSVDYNGEQKQIRLCRELSDLVSICKSVQYRD 501
Query: 641 IE--MEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPF 698
E M++ + W++ SFSET+A +I + P ++ +N++ LSRIYPS+ R+DSSN NPQ F
Sbjct: 502 FELSMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDF 561
Query: 699 WNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGV--FNPNSEDPLPGQL 756
WN GCQ+VA+N+Q+ G M+ L+ F NGGCGYVL+P M V F+ N++ LPG
Sbjct: 562 WNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGILPGVS 621
Query: 757 KKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPT 816
L ++IISGQ PKP+ + +G++IDP+V +EI G+P DCS ++T+ V N NP
Sbjct: 622 PLALHIKIISGQNFPKPKGACA--KGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPI 679
Query: 817 WEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEG-----ME 871
++ET F V++PE+A++RF+V D D IG +FIGQ T+ F + PGYRHV L ME
Sbjct: 680 FDETFEFQVNLPELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIME 739
Query: 872 EASIFVHVAVSDISG 886
++FVH+A+++ SG
Sbjct: 740 HVTLFVHIAITNRSG 754
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 348 bits (894), Expect = 2e-95
Identities = 249/768 (32%), Positives = 378/768 (49%), Gaps = 97/768 (12%)
Query: 135 LVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEV 194
+V+ + EV + WV GLR ++ ++++ + W+K F N +G + + +
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
Query: 195 LQLLHKLNVN-LPRQRVKQMFREADTDDH--QGTLGFEEFCAFYKMMSTRRDLYLLMLTY 251
+ + Q +K++ + +D +E+F + + R D+ L
Sbjct: 170 TRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKI 229
Query: 252 SNHK-DHLDAASLQRFLQVEQKMAGVT--------LESCQDIIEQFEPCPENKSKGLLGI 302
+ K D+L L FL Q+ + + IIE +EP + K KGL+
Sbjct: 230 NGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISS 289
Query: 303 DGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWV 362
DGF Y S + ++Q+M PL+HYFI+SSHNTYL G Q +S V+MY V
Sbjct: 290 DGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQV 349
Query: 363 LQAGCRCVEVDCWDGP--DGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE 420
L AGCRCVE+DCWDG D EPI+ HG + + ILFKDVI+ I + AF+ +EYPVILS E
Sbjct: 350 LLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFE 409
Query: 421 NHCSVIQQKKMAQYLTDILGD---KLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANI 477
NHCS QQ KM++Y D+ GD K L S E LPSP LK KIL+K K+L +
Sbjct: 410 NHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEV 469
Query: 478 SEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPN 537
+ E S ++ G++++ +E+ + +++S +E +
Sbjct: 470 EKKQLEALRSMMEA------------GESASPANILEDDNEEEIESADQEEEAH------ 511
Query: 538 NFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVE 597
P K G + A++ G K A SV+
Sbjct: 512 --------PEFKFGNELSADD---------------------------LGHKEAVANSVK 536
Query: 598 EGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEM--EAASSWQVSSFS 655
+G + T + LS ++ Y + V + E + +SSF+
Sbjct: 537 KGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFN 596
Query: 656 ETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGR 715
E+ L+ +++ +N++Q+SRIYP RVDSSNY PQ FWNAGCQMV+LNYQ+
Sbjct: 597 ESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDL 656
Query: 716 MLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRIISGQQLPKP 773
+QLN+ KF NG CGY+LKP M + F+P SE P+ G + +++ISGQ L
Sbjct: 657 AMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDK 716
Query: 774 RDSMLGDRGEIIDPFVEVEIIGLPVDCSREQ--TRVVDDNGFNPTW-EETLVF-MVHMPE 829
+ I +VEV++ GLP D R++ TR+V +NG NP + EE+ VF V +P+
Sbjct: 717 K----------IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPD 766
Query: 830 IALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL--EGMEEASI 875
+A++R V+D + IGQR L + GYRH+ L EG + S+
Sbjct: 767 LAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSL 811
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 348 bits (894), Expect = 2e-95
Identities = 249/768 (32%), Positives = 378/768 (49%), Gaps = 97/768 (12%)
Query: 135 LVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEV 194
+V+ + EV + WV GLR ++ ++++ + W+K F N +G + + +
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
Query: 195 LQLLHKLNVN-LPRQRVKQMFREADTDDH--QGTLGFEEFCAFYKMMSTRRDLYLLMLTY 251
+ + Q +K++ + +D +E+F + + R D+ L
Sbjct: 170 TRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKI 229
Query: 252 SNHK-DHLDAASLQRFLQVEQKMAGVT--------LESCQDIIEQFEPCPENKSKGLLGI 302
+ K D+L L FL Q+ + + IIE +EP + K KGL+
Sbjct: 230 NGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISS 289
Query: 303 DGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWV 362
DGF Y S + ++Q+M PL+HYFI+SSHNTYL G Q +S V+MY V
Sbjct: 290 DGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQV 349
Query: 363 LQAGCRCVEVDCWDGP--DGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE 420
L AGCRCVE+DCWDG D EPI+ HG + + ILFKDVI+ I + AF+ +EYPVILS E
Sbjct: 350 LLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFE 409
Query: 421 NHCSVIQQKKMAQYLTDILGD---KLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANI 477
NHCS QQ KM++Y D+ GD K L S E LPSP LK KIL+K K+L +
Sbjct: 410 NHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEV 469
Query: 478 SEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPN 537
+ E S ++ G++++ +E+ + +++S +E +
Sbjct: 470 EKKQLEALRSMMEA------------GESASPANILEDDNEEEIESADQEEEAH------ 511
Query: 538 NFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVE 597
P K G + A++ G K A SV+
Sbjct: 512 --------PEFKFGNELSADD---------------------------LGHKEAVANSVK 536
Query: 598 EGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEM--EAASSWQVSSFS 655
+G + T + LS ++ Y + V + E + +SSF+
Sbjct: 537 KGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFN 596
Query: 656 ETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGR 715
E+ L+ +++ +N++Q+SRIYP RVDSSNY PQ FWNAGCQMV+LNYQ+
Sbjct: 597 ESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDL 656
Query: 716 MLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRIISGQQLPKP 773
+QLN+ KF NG CGY+LKP M + F+P SE P+ G + +++ISGQ L
Sbjct: 657 AMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDK 716
Query: 774 RDSMLGDRGEIIDPFVEVEIIGLPVDCSREQ--TRVVDDNGFNPTW-EETLVF-MVHMPE 829
+ I +VEV++ GLP D R++ TR+V +NG NP + EE+ VF V +P+
Sbjct: 717 K----------IGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPD 766
Query: 830 IALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL--EGMEEASI 875
+A++R V+D + IGQR L + GYRH+ L EG + S+
Sbjct: 767 LAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSL 811
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 345 bits (886), Expect = 1e-94
Identities = 197/474 (41%), Positives = 279/474 (58%), Gaps = 14/474 (2%)
Query: 49 MQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRW--RPSRKNEKAKISIDSIQEVSEGRQSE 106
MQEGM M K+R S +R++ L + W R +R + K SI ++ + G SE
Sbjct: 18 MQEGMPMRKVRSKSWKKLRYFRLQNDGMTV-WHARQARGSAKPSFSISDVETIRNGHDSE 76
Query: 107 VFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARR 166
+ + + ++HG R +LDL++ S E A+ W+ GL+ L+ ++ D
Sbjct: 77 LLRSLAEELPLEQGFTIVFHG-RRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
Query: 167 QRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTL 226
Q DQWL F DKN DG +S EV +LLH +NV + ++ +F+ ADT GTL
Sbjct: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQ-SGTL 190
Query: 227 GFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIE 286
EEF FYK ++ R ++ L ++S L FLQ EQK T E ++I+
Sbjct: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
Query: 287 QFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLV 346
++EP K + +L +DGF +Y S GDIFNP ++QDMTQPL+HYFI SSHNTYLV
Sbjct: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
Query: 347 GDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKY 406
GDQL QS V+ Y L+ GCRCVEVD WDGP GEP+V+HG+TLTS+ILFKDV+ T+ +Y
Sbjct: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
Query: 407 AFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKI 466
AF ++YPVILS+E HCS QQ+ MA++LT+ILG++L +++ T LPSP+ L+ KI
Sbjct: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
Query: 467 LVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRK 520
LVKGKKL E+ E +E++ E+++ L T + E + K
Sbjct: 431 LVKGKKLTLE-----EDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNK 479
Score = 226 bits (575), Expect = 2e-58
Identities = 129/301 (42%), Positives = 187/301 (62%), Gaps = 17/301 (5%)
Query: 595 SVEEGDEGQDSPGGQSRGATRQKKTMK--LSRALSDLVKYTKSVATHDI--EMEAASSWQ 650
++E E + P Q+ +KK K L ALS LV Y KSV+ E ++
Sbjct: 460 ALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYE 519
Query: 651 VSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNY 710
+SSFSETKA +++++ ++++ N QLSR+YPS R DSSNYNPQ WNAGCQMVA+N
Sbjct: 520 ISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNM 579
Query: 711 QSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNPNSEDPLPGQLKKQLVLRIISGQ 768
Q+ G + + F NGGCGYVLKP + Q F+P E P+ + L++++ISGQ
Sbjct: 580 QTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVISGQ 637
Query: 769 QLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMP 828
QLPK + G I+DP V+V+I G+ +D +R++T V++NGFNP W +TL F V +P
Sbjct: 638 QLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVP 694
Query: 829 EIALVRFLVWDHDPIGR-DFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIFVHVAVS 882
E+A++RF+V D+D R DFIGQ TL ++ M GYRH++L + ASIFV++ +
Sbjct: 695 ELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQ 754
Query: 883 D 883
+
Sbjct: 755 E 755
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 318 bits (816), Expect = 2e-86
Identities = 240/787 (30%), Positives = 372/787 (47%), Gaps = 142/787 (18%)
Query: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEA--DKNGDGSLS 190
L+LV+ EVA+ W + L +L + +RD +L++ + + +G +
Sbjct: 117 LNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPEGRIP 170
Query: 191 IGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQG-TLGFEEFC-----AFYKMMSTRRDL 244
+ + +L + R+RV+ + ++ E+F F + R ++
Sbjct: 171 LKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEI 225
Query: 245 YLLMLTY-SNHKDHLDAASLQRFLQVEQK--------MAGVTLESCQDIIEQFEPCPENK 295
+ + + K +L + F+ ++Q+ + E Q +IE++EP
Sbjct: 226 DNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLA 285
Query: 296 SKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSR 355
KG + +DGF Y + +PE +++DM+QPLSHYFI SSHNTYL QL S
Sbjct: 286 RKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSS 345
Query: 356 VDMYAWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEY 413
V+MY VL +GCRCVE+DCW G + EP++ HG+T+T++I FK+VIE I + AF + +
Sbjct: 346 VEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPF 405
Query: 414 PVILSIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSEDATTLPSPQMLKGKILVK 469
P++LS ENH S QQ KMA+Y I GD L L E LPSP L KILVK
Sbjct: 406 PILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVK 465
Query: 470 GKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESK 529
KK + K E + K+KL
Sbjct: 466 NKK-----------------------------------KSHKSSEGSGKKKLSE------ 484
Query: 530 IRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSK 589
+ + S S PS ++ E D + +D
Sbjct: 485 --QASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDC---------------------- 520
Query: 590 LKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVA--THDIEMEAAS 647
K +S++EG G ++ + +S+LV Y + V + +I +
Sbjct: 521 --KKSSMDEGTAGSEAMATEE---------------MSNLVNYIQPVKFESFEISKKRNK 563
Query: 648 SWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVA 707
S+++SSF ETK + L + P +++ +N+ QLSRIYP RVDSSNY PQ FWNAGCQMVA
Sbjct: 564 SFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVA 623
Query: 708 LNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRII 765
LN+Q+ +Q+N + NG GY LKP M + F+P +E + G + L ++II
Sbjct: 624 LNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKII 683
Query: 766 SGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE--QTRVVDDNGFNPTW-EETLV 822
SGQ L + + +VEV++ GLPVD R+ +T+ N NP W EE +V
Sbjct: 684 SGQFLSDKK----------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIV 733
Query: 823 F-MVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIF 876
F V +P +A +R V++ G FIG R L ++ PGY ++ L + + ++F
Sbjct: 734 FKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
Query: 877 VHVAVSD 883
V++ V D
Sbjct: 791 VYIEVKD 797
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 318 bits (816), Expect = 2e-86
Identities = 240/787 (30%), Positives = 372/787 (47%), Gaps = 142/787 (18%)
Query: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEA--DKNGDGSLS 190
L+LV+ EVA+ W + L +L + +RD +L++ + + +G +
Sbjct: 117 LNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPEGRIP 170
Query: 191 IGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQG-TLGFEEFC-----AFYKMMSTRRDL 244
+ + +L + R+RV+ + ++ E+F F + R ++
Sbjct: 171 LKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEI 225
Query: 245 YLLMLTY-SNHKDHLDAASLQRFLQVEQK--------MAGVTLESCQDIIEQFEPCPENK 295
+ + + K +L + F+ ++Q+ + E Q +IE++EP
Sbjct: 226 DNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLA 285
Query: 296 SKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSR 355
KG + +DGF Y + +PE +++DM+QPLSHYFI SSHNTYL QL S
Sbjct: 286 RKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSS 345
Query: 356 VDMYAWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEY 413
V+MY VL +GCRCVE+DCW G + EP++ HG+T+T++I FK+VIE I + AF + +
Sbjct: 346 VEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPF 405
Query: 414 PVILSIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSEDATTLPSPQMLKGKILVK 469
P++LS ENH S QQ KMA+Y I GD L L E LPSP L KILVK
Sbjct: 406 PILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVK 465
Query: 470 GKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESK 529
KK + K E + K+KL
Sbjct: 466 NKK-----------------------------------KSHKSSEGSGKKKLSE------ 484
Query: 530 IRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSK 589
+ + S S PS ++ E D + +D
Sbjct: 485 --QASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDC---------------------- 520
Query: 590 LKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVA--THDIEMEAAS 647
K +S++EG G ++ + +S+LV Y + V + +I +
Sbjct: 521 --KKSSMDEGTAGSEAMATEE---------------MSNLVNYIQPVKFESFEISKKRNK 563
Query: 648 SWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVA 707
S+++SSF ETK + L + P +++ +N+ QLSRIYP RVDSSNY PQ FWNAGCQMVA
Sbjct: 564 SFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVA 623
Query: 708 LNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKKQLVLRII 765
LN+Q+ +Q+N + NG GY LKP M + F+P +E + G + L ++II
Sbjct: 624 LNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKII 683
Query: 766 SGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE--QTRVVDDNGFNPTW-EETLV 822
SGQ L + + +VEV++ GLPVD R+ +T+ N NP W EE +V
Sbjct: 684 SGQFLSDKK----------VGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIV 733
Query: 823 F-MVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIF 876
F V +P +A +R V++ G FIG R L ++ PGY ++ L + + ++F
Sbjct: 734 FKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVF 790
Query: 877 VHVAVSD 883
V++ V D
Sbjct: 791 VYIEVKD 797
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 313 bits (803), Expect = 6e-85
Identities = 271/899 (30%), Positives = 404/899 (44%), Gaps = 96/899 (10%)
Query: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEA--DKNGDGSLS 190
L+ ++ + A+ W L L I +++ +R+ +L++ + + N DG +
Sbjct: 118 LNFMAVQDDTAKVWSEELFKLAMNILAQNA------SRNTFLRKAYTKLKLQVNQDGRIP 171
Query: 191 IGEVLQLLH--KLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLM 248
+ +L++ K V + F +++ E F F + R D+ ++
Sbjct: 172 VKNILKMFSADKKRVETALESCGLKFNRSESI-RPDEFSLEIFERFLNKLCLRPDIDKIL 230
Query: 249 LTY-SNHKDHLDAASLQRFLQVEQK--------MAGVTLESCQDIIEQFEPCPENKSKGL 299
L + K +L L F+ +Q+ + + +IE++EP + +
Sbjct: 231 LEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQ 290
Query: 300 LGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359
+ ++GF+ Y I E + DMTQPLS YFI SSHNTYL QL S V+MY
Sbjct: 291 MSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMY 350
Query: 360 AWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVIL 417
L GCRCVE+D W G P+ EP + HG+T+T+++ +DV+E I + AF + YPVIL
Sbjct: 351 RQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVIL 410
Query: 418 SIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSEDATTLPSPQMLKGKILVKGKKL 473
S ENH S QQ KMA+Y I GD L L LPSPQ L G+ILVK KK
Sbjct: 411 SFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKK- 469
Query: 474 PANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLD--SLIKESKIR 531
SA G S RKR + L S E
Sbjct: 470 -------------RHRPSA----------GGPDSAGRKRPLEQSNSALSESSAATEPSSP 506
Query: 532 DCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLK 591
P++ S LS ++G + + E +S D G +R G V+G R ++
Sbjct: 507 QLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLNR--GPYVLGPADREDEEE---- 560
Query: 592 KAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASS--W 649
+E +E Q P + + + +S LV Y + V E + +
Sbjct: 561 -----DEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF 615
Query: 650 QVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALN 709
++SSF ETKA + L + P +++ +N+QQLSRIYP RVDSSNY PQ FWN GCQ+VALN
Sbjct: 616 EMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALN 675
Query: 710 YQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQG--VFNPNSEDPLPGQLKKQLVLRIISG 767
+Q+ +QLN F NG GY+LKP M + F+P +E + G + L +++ISG
Sbjct: 676 FQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISG 735
Query: 768 QQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE-QTRVVDDNGFNPTW-EETLVF-M 824
Q L DR + +VEV++ GLPVD R+ +TR N FNP W EE F
Sbjct: 736 Q--------FLSDRK--VGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPK 785
Query: 825 VHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEA-----SIFVHV 879
V +P +A +R ++ G F+G R L S++ GY +V L ++ ++
Sbjct: 786 VVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYT 842
Query: 880 AVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKP 939
SD Q + K SL A + A S+ + T+SQ+
Sbjct: 843 EASDYIPDDHQDYA--EALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL 900
Query: 940 GRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLP 998
G + + T S A PPGP +P + + PG LS P P
Sbjct: 901 GSQP------SSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTP 953
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 305 bits (780), Expect = 3e-82
Identities = 179/468 (38%), Positives = 260/468 (55%), Gaps = 15/468 (3%)
Query: 37 QLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRW--RPSRKNEKAKISID 94
++G + + AM G ++ K+R + R Y L E + + R R + +
Sbjct: 53 KMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQ 112
Query: 95 SIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLM 154
I+ V EG QSE +R+ G+F P C +I R++LDL + ++E A+ WV GL L
Sbjct: 113 HIEAVREGHQSEGLRRF-GGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLR 171
Query: 155 AGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMF 214
A + D++++R+R D W+ AD N D +S E+ LL +NV++ +F
Sbjct: 172 ARL---DAMSQRERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLF 227
Query: 215 READTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMA 274
+E D ++ G E F + + R +L + YS L A L FL+ +Q
Sbjct: 228 KECDHSNNDRLEG-AEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEE 285
Query: 275 GVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSH 334
G TL Q +I+ +E K L+ +DGF Y SP G + H V QDM QPL+H
Sbjct: 286 GATLARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAH 345
Query: 335 YFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKI 394
YFI+SSHNTYL Q+ S + Y GCRCVE+DCW+GP GEP+++HG+TLTSKI
Sbjct: 346 YFISSSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKI 405
Query: 395 LFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDAT 454
LF+DV++ + +AF + YPVILS+ENHC + QQ MA++L ILGD L ++ S +
Sbjct: 406 LFRDVVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPE 465
Query: 455 TLPSPQMLKGKILVKGKKLPANISEDA------EEGEVSDEDSADEID 496
LPSP+ LKG++LVKGKKLPA SED EE E DE+ +E++
Sbjct: 466 ELPSPEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVE 513
Score = 214 bits (544), Expect = 6e-55
Identities = 117/298 (39%), Positives = 174/298 (58%), Gaps = 15/298 (5%)
Query: 583 RKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIE 642
R + G L EE DE ++ + A +++ ++S LS L Y + +
Sbjct: 488 RSEDGRALSDREEEEEDDEEEEE---EVEAAAQRRLAKQISPELSALAVYCHATRLRTLH 544
Query: 643 M--EAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWN 700
A QVSS SE KA +++++ ++R N +QL+R+YP R++S+NY+PQ WN
Sbjct: 545 PAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHNARQLTRVYPLGLRMNSANYSPQEMWN 604
Query: 701 AGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNSEDPLPGQLKK 758
+GCQ+VALN+Q+ G + LN +F NG CGYVLKP C+ Q F+P PG +
Sbjct: 605 SGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPACLRQPDSTFDPE----YPGPPRT 660
Query: 759 QLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWE 818
L +++++ QQLPK I+DP V +EI G+P DC+R++T V +NGFNP W
Sbjct: 661 TLSIQVLTAQQLPKLNAE---KPHSIVDPLVRIEIHGVPADCARQETDYVLNNGFNPRWG 717
Query: 819 ETLVFMVHMPEIALVRFLVWDHDPIG-RDFIGQRTLAFSSMMPGYRHVYLEGMEEASI 875
+TL F + PE+ALVRF+V D+D DF+GQ TL SS+ GYRH++L + AS+
Sbjct: 718 QTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSSLKQGYRHIHLLSKDGASL 775
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 303 bits (777), Expect = 6e-82
Identities = 185/470 (39%), Positives = 263/470 (55%), Gaps = 16/470 (3%)
Query: 37 QLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRK----NEKAKIS 92
+LG + + A+ +G Q++K++ S RFY L E I W+ SRK E S
Sbjct: 31 RLGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFS 89
Query: 93 IDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRY 152
I+ IQEV G ++E +++ + CFSI R +LDL++ S A+ WV GL
Sbjct: 90 IEDIQEVRMGHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHK 148
Query: 153 LMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQ 212
+ I S+ +RQ+ + W+ +ADKN D +S E+ L +LN+ + ++
Sbjct: 149 I---IHHSGSMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARK 204
Query: 213 MFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQK 272
+FRE D +L EE AFYKM++ R ++ + + L L FLQ +Q+
Sbjct: 205 IFRECD-HSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQR 263
Query: 273 MAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPL 332
+IE++EP K++ + DGF Y S G F+ H V+QDM QPL
Sbjct: 264 EEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPL 323
Query: 333 SHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTS 392
SHY ++SSHNTYL+ DQL S + Y L GCRC+E+DCWDGP+ EPI++HGYT TS
Sbjct: 324 SHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTS 383
Query: 393 KILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSED 452
KILF DV+ I YAF + YPVILS+ENHC++ QQ+ MA++L ILG L L+
Sbjct: 384 KILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPML-LNRPLDGV 442
Query: 453 ATTLPSPQMLKGKILVKGKKLPANISEDAEEGE----VSDEDSADEIDDD 498
+LPSP+ LKGKIL+KGKKL + E G VSDED A E++D+
Sbjct: 443 TNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
Score = 211 bits (537), Expect = 4e-54
Identities = 120/306 (39%), Positives = 179/306 (58%), Gaps = 18/306 (5%)
Query: 592 KAASVEEGDEGQDSPGGQSRGATRQKKT---MKLSRALSDLVKYTKSVATHDIEMEAASS 648
+A V + DE + R + K ++L++ LSD+V Y KSV
Sbjct: 476 EATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPG 535
Query: 649 ---WQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQM 705
++++SFSE +A ++LQ+ ++R N LSRIYP+ +R DSSNY+P WN GCQ+
Sbjct: 536 QAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQI 595
Query: 706 VALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNPNSEDPLPGQLKKQLVLR 763
VALN+Q+ G + + + +F NG CGYVLKP + G FNP + P +K+L +R
Sbjct: 596 VALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIR 655
Query: 764 IISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVF 823
+ISGQQLPK ++ I+DP V VEI G+ D + QT V+ +NGFNP W+ F
Sbjct: 656 VISGQQLPKVNK----NKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAF 711
Query: 824 MVHMPEIALVRFLVWDHDPIGR-DFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIFV 877
V +P++AL+RFLV D+D + DFIGQ T+ +S+ GYRHV+L + A++FV
Sbjct: 712 EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFV 771
Query: 878 HVAVSD 883
+++ D
Sbjct: 772 KISLQD 777
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 303 bits (775), Expect = 1e-81
Identities = 183/459 (39%), Positives = 258/459 (56%), Gaps = 16/459 (3%)
Query: 48 AMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRK----NEKAKISIDSIQEVSEGR 103
A+ +G Q++K++ S RFY L E I W+ SRK E SI+ IQEV G
Sbjct: 21 ALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRMGH 79
Query: 104 QSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSL 163
++E +++ + CFSI R +LDL++ S A+ WV GL + I S+
Sbjct: 80 RTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSGSM 135
Query: 164 ARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQ 223
+RQ+ + W+ +ADKN D +S E+ L +LN+ + +++FRE D
Sbjct: 136 DQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECD-HSQT 193
Query: 224 GTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQD 283
+L EE AFYKM++ R ++ + + L L FLQ +Q+
Sbjct: 194 DSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALS 253
Query: 284 IIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNT 343
+IE++EP K++ + DGF Y S G F+ H V+QDM QPLSHY ++SSHNT
Sbjct: 254 LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNT 313
Query: 344 YLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETI 403
YL+ DQL S + Y L GCRC+E+DCWDGP+ EPI++HGYT TSKILF DV+ I
Sbjct: 314 YLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAI 373
Query: 404 NKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLK 463
YAF + YPVILS+ENHC++ QQ+ MA++L ILG L L+ +LPSP+ LK
Sbjct: 374 RDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPML-LNRPLDGVTNSLPSPEQLK 432
Query: 464 GKILVKGKKLPANISEDAEEGE----VSDEDSADEIDDD 498
GKIL+KGKKL + E G VSDED A E++D+
Sbjct: 433 GKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 471
Score = 211 bits (537), Expect = 4e-54
Identities = 120/306 (39%), Positives = 179/306 (58%), Gaps = 18/306 (5%)
Query: 592 KAASVEEGDEGQDSPGGQSRGATRQKKT---MKLSRALSDLVKYTKSVATHDIEMEAASS 648
+A V + DE + R + K ++L++ LSD+V Y KSV
Sbjct: 455 EATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPG 514
Query: 649 ---WQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQM 705
++++SFSE +A ++LQ+ ++R N LSRIYP+ +R DSSNY+P WN GCQ+
Sbjct: 515 QAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQI 574
Query: 706 VALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNPNSEDPLPGQLKKQLVLR 763
VALN+Q+ G + + + +F NG CGYVLKP + G FNP + P +K+L +R
Sbjct: 575 VALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIR 634
Query: 764 IISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVF 823
+ISGQQLPK ++ I+DP V VEI G+ D + QT V+ +NGFNP W+ F
Sbjct: 635 VISGQQLPKVNK----NKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAF 690
Query: 824 MVHMPEIALVRFLVWDHDPIGR-DFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIFV 877
V +P++AL+RFLV D+D + DFIGQ T+ +S+ GYRHV+L + A++FV
Sbjct: 691 EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFV 750
Query: 878 HVAVSD 883
+++ D
Sbjct: 751 KISLQD 756
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 298 bits (763), Expect = 2e-80
Identities = 208/668 (31%), Positives = 324/668 (48%), Gaps = 91/668 (13%)
Query: 277 TLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIF-NPEHHHVHQDMTQPLSHY 335
T + II++FEP +GL+ +GF + N E +++ PLS+Y
Sbjct: 1342 TYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDESQENIKELQLPLSYY 1401
Query: 336 FITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKIL 395
+I SSHNTYL G QL +S V++Y+ VL GCR VE+DCWDG DG PI++HG+TLT+KI
Sbjct: 1402 YIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDGMPIIYHGHTLTTKIP 1461
Query: 396 FKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKL---DLSSVSSED 452
FK+V+E I++ AFI ++ P+I+SIENHCS+ QQ+KMA+ + G+KL L D
Sbjct: 1462 FKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFGEKLVTKFLFETDFSD 1521
Query: 453 ATTLPSPQMLKGKILVKGKKLPAN------ISEDAEE-------------------GEVS 487
LPSP L+ K+L+K KKL A+ + + A +
Sbjct: 1522 DPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQAYNGGNANPRPANNEE 1581
Query: 488 DEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPS 547
+ED DE D D + L+ D + + KL E + + +N + +
Sbjct: 1582 EEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKRIKKADNSACN----K 1637
Query: 548 GKLGRKSKAEEDVESGED--AGASRRNGRLVVGSFS-------------------RRKKK 586
GK+ D+E GE+ +++ R + S +
Sbjct: 1638 GKV-------YDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNASGSSR 1690
Query: 587 GSKLKKAASVEEGDEGQDSPG-----GQSRGATRQKKTMKLSRALSDLVKYTKSVATHDI 641
G + K S+ + G+ SPG ++ G + + + S + T S++
Sbjct: 1691 GKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLSA--- 1747
Query: 642 EMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNA 701
+ + +SS +E A ++ ++ + + QL R YP++ R+DSSN NP FW
Sbjct: 1748 IIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWLH 1807
Query: 702 GCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKP------GCMCQGVFNPNSEDPLPGQ 755
G Q+VALNYQ++ L LN A F ANGGCGYVLKP C F+P D L
Sbjct: 1808 GIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERD-LDSM 1866
Query: 756 LKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNP 815
L I+SGQ + P +SM P +EV+++G+P+D +T+ + N NP
Sbjct: 1867 DPAVYSLTIVSGQNV-CPSNSM-------GSPCIEVDVLGMPLDSCHFRTKPIHRNTLNP 1918
Query: 816 TWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYL-----EGM 870
W E +F VH ++ +RF V +++ QR + ++ GYRH+ L E +
Sbjct: 1919 MWNEQFLFHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYRHLQLRNLHNEVL 1976
Query: 871 EEASIFVH 878
E +S+F++
Sbjct: 1977 EISSLFIN 1984
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 284 bits (727), Expect = 4e-76
Identities = 250/813 (30%), Positives = 361/813 (44%), Gaps = 179/813 (22%)
Query: 279 ESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFIT 338
+ Q +I+++EP N +G L +G + P + + +H DMTQPL+HYFI
Sbjct: 265 DQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFIN 324
Query: 339 SSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDG--PDGEPIVHHGYTLTSKILF 396
SSHNTYL Q S +MY VL +GCRCVE+DCW G PD EPI+ HG+T+T+ I F
Sbjct: 325 SSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFF 384
Query: 397 KDVIETINKYAFIKNEYPVILSIENHC-SVIQQKKMAQYLTDILGDKL---DLSSVSSED 452
K+ IE I + AF + YP+ILS ENH S QQ KMA+Y I GD L L +
Sbjct: 385 KEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKP 444
Query: 453 ATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKR 512
LPSP+ L+ GK L N S +D+ E + G + +
Sbjct: 445 GVPLPSPEDLR------GKILIKNKKNQFSGPTSSSKDTGGEAE-------GSSPPSAPA 491
Query: 513 VENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRN 572
E T +G+ G + + EE+VE E+ +
Sbjct: 492 GEGTVW----------------------------AGEEGTELE-EEEVEEEEE----EES 518
Query: 573 GRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKY 632
G L ++KK S +EG G + + +S LV Y
Sbjct: 519 GNL----------DEEEIKKMQS-DEGTAGLEVTAYEE---------------MSSLVNY 552
Query: 633 TKSVATHDIEMEAAS--SWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDS 690
+ E A S+ +SSF+E KA+ +L + Q++ +N++Q+SRIYP R+DS
Sbjct: 553 IQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDS 612
Query: 691 SNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQ--GVFNPNS 748
SNY PQ FWNAGCQMVALN+Q+ +Q N A F NG GY+LK M + FNP S
Sbjct: 613 SNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFS 672
Query: 749 EDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSRE-QTRV 807
D + + L + +ISGQ L +R + +VEVE+ GLP D R +T++
Sbjct: 673 VDRIDVVVATTLSITVISGQ--------FLSERS--VRTYVEVELFGLPGDPKRRYRTKL 722
Query: 808 -VDDNGFNPTW-EETLVF-MVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRH 864
N NP W EE VF + MPE+A +R V + G F+G R + +++ GY H
Sbjct: 723 SPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHH 779
Query: 865 VYLEG-----MEEASIFVHVAVSDI-------------------------SGKVKQALG- 893
+ L + ++F+ + + D S K+K+A+G
Sbjct: 780 LCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGG 839
Query: 894 --LKGLFLRGPKP----GSLDSHAAGRPPARPSVSQRILRRTASAPTKS----------- 936
K L P G+L + G P AR + ++ A T S
Sbjct: 840 LPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVV 899
Query: 937 -------------QKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSG 983
++ G R + EL+ G+ +A ++ PPG G + GPG G
Sbjct: 900 KLQRRHEKELRELERRGARRWEELL----QRGAAQLA-ELGPPGVGGV--GACKLGPGKG 952
Query: 984 SPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGP 1016
S + +R LP + APG GP
Sbjct: 953 SRK-------KRSLP-----REESAGAAPGEGP 973
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 245 bits (626), Expect = 2e-64
Identities = 132/308 (42%), Positives = 192/308 (62%), Gaps = 2/308 (0%)
Query: 187 GSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYL 246
G +++ + +LL KL++ VKQ+F++ D QG + EEF A Y++++ R ++
Sbjct: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
Query: 247 LMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFT 306
+ TYS ++ L A++L +FL EQ A ++ +II+++EP E + + ++GFT
Sbjct: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
Query: 307 NYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAG 366
Y S +F E V+QDMT PL+ YFI+SSHNTYLV DQL+ S + Y L G
Sbjct: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
Query: 367 CRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVI 426
CRC+E+DCWDG EP+V+HGYTLTSK+LFK VI+ I+KYAF+ ++YPV+LS+ENHCS
Sbjct: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
Query: 427 QQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEV 486
QQ+ MA L G+ L LS + + TLPSP+ LK KILVK KK+ +G
Sbjct: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERKGSD 314
Query: 487 SDEDSADE 494
D+ D+
Sbjct: 315 KRGDNQDK 322
Score = 188 bits (478), Expect = 3e-47
Identities = 121/317 (38%), Positives = 179/317 (56%), Gaps = 35/317 (11%)
Query: 589 KLKKAASVEEGDE--GQDSPGGQSRGAT-----------RQKKT--MKLSRALSDLVKYT 633
K KK +++E E G D G T ++KKT +K++ ALSDLV YT
Sbjct: 297 KNKKIGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYT 356
Query: 634 KSVATHDIEMEAASSW--QVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSS 691
K+ + + +S ET+A ++ + + +++ ++ ++RIYP + R DSS
Sbjct: 357 KAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSS 416
Query: 692 NYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNP-NS 748
N+NPQ FWN GCQMVALN+Q+ G + L KF NGG GY+LKP + + FNP N
Sbjct: 417 NFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNI 476
Query: 749 EDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVV 808
++ +P L +R+ISG QLP S ++G D V +E+ G+P D ++QTRV+
Sbjct: 477 KEGMP----ITLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVI 527
Query: 809 DDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPI-GRDFIGQRTLAFSSMMPGYRHVYL 867
N F+P W ET F++H+PE+AL+RF+V I G +F+GQ TL M GYR + L
Sbjct: 528 KKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPL 587
Query: 868 -----EGMEEASIFVHV 879
E +E AS+FV+V
Sbjct: 588 FSRMGESLEPASLFVYV 604
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 244 bits (622), Expect = 6e-64
Identities = 160/445 (35%), Positives = 236/445 (53%), Gaps = 29/445 (6%)
Query: 78 IRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYP-DGSFDPNC--CFSIYHGSH--RES 132
I W + I I I+E+ G+ S F RY D +F P+ CF I +G ++
Sbjct: 60 ITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKT 119
Query: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSL-ARRQRTRDQWLKQTFDEADKNGDGSLSI 191
L L +TS + W+ GL +LM ED+L A ++WL++ F D+N + +S
Sbjct: 120 LSLQATSEDEVNMWIKGLTWLM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISA 174
Query: 192 GEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYK--MMSTRRDLYLLML 249
++ +L ++N +P R + R D + G + + +F Y+ M S ++ + L L
Sbjct: 175 KDLKNMLSQVNYRVPNMRFLRE-RLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFL 233
Query: 250 TYSN----HKDHLDAASLQRF----LQVEQKMAGVTLESCQDIIEQFEPCPENK-SKGLL 300
S + L SL F L + ++ V Q+ + F P + +
Sbjct: 234 EASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYF 293
Query: 301 GIDGFTNYTRSPAGDIFNPEHHHVHQD-MTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359
+D F + S ++N + V D M PLSHY+I+SSHNTYL GDQ S+S ++ Y
Sbjct: 294 FLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAY 353
Query: 360 AWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSI 419
A L+ GCRC+E+DCWDGPDG P+++HG+TLT+KI F DV+ TI ++AF+ +EYPVILSI
Sbjct: 354 ARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSI 413
Query: 420 ENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISE 479
E+HCS+ QQ+ MAQY +LGD L L+ A LPSP LK KIL+K KKL +E
Sbjct: 414 EDHCSIAQQRNMAQYFKKVLGDTL-LTKPVEISADGLPSPNQLKRKILIKHKKL----AE 468
Query: 480 DAEEGEVSDEDSADEIDDDCKLLNG 504
+ EV E D + NG
Sbjct: 469 GSAYEEVPTSMMYSENDISNSIKNG 493
Score = 169 bits (428), Expect = 2e-41
Identities = 111/330 (33%), Positives = 172/330 (52%), Gaps = 27/330 (8%)
Query: 571 RNGRLVVGSFSRRKKKGSKLKKAASVEEG---------DEGQDSPGGQSRGATRQKKTMK 621
+N RL V S S L AA +E + Q + + G +++ K
Sbjct: 890 KNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRK-K 948
Query: 622 LSRALSDLVKYTKSVATHD--IEMEAASSWQVSSFSETKAHQILQQ-KPAQYLRFNQQQL 678
++ LS+LV Y + V + I E A +SSF ETKA + + + K ++L++N+ QL
Sbjct: 949 IALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQL 1008
Query: 679 SRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGC 738
SRIYP R+DSSNY+P P W G Q+VALN+Q+ + +Q+N+A F CGYVL+P
Sbjct: 1009 SRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPST 1068
Query: 739 MCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPV 798
M F+P + L G + + ++ + LPK RG I+ PFVE+E+ G
Sbjct: 1069 MRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPFVEIEVAGAEY 1121
Query: 799 DCSREQTRVVDDNGFNPTW-EETLVFMVHMPEIALVRFLVWDHDPIG-RDFIGQRTLAFS 856
D ++++T V DNG NP W + F + PE A +RF+V++ D ++F+ Q T
Sbjct: 1122 DSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVK 1181
Query: 857 SMMPGYRHV-----YLEGMEEASIFVHVAV 881
+ GYR V Y E +E AS+ + + +
Sbjct: 1182 GLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 244 bits (622), Expect = 6e-64
Identities = 160/445 (35%), Positives = 236/445 (53%), Gaps = 29/445 (6%)
Query: 78 IRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYP-DGSFDPNC--CFSIYHGSH--RES 132
I W + I I I+E+ G+ S F RY D +F P+ CF I +G ++
Sbjct: 60 ITWSRGADKIEGAIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKT 119
Query: 133 LDLVSTSSEVARTWVTGLRYLMAGISDEDSL-ARRQRTRDQWLKQTFDEADKNGDGSLSI 191
L L +TS + W+ GL +LM ED+L A ++WL++ F D+N + +S
Sbjct: 120 LSLQATSEDEVNMWIKGLTWLM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISA 174
Query: 192 GEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYK--MMSTRRDLYLLML 249
++ +L ++N +P R + R D + G + + +F Y+ M S ++ + L L
Sbjct: 175 KDLKNMLSQVNYRVPNMRFLRE-RLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFL 233
Query: 250 TYSN----HKDHLDAASLQRF----LQVEQKMAGVTLESCQDIIEQFEPCPENK-SKGLL 300
S + L SL F L + ++ V Q+ + F P + +
Sbjct: 234 EASTLRAGERPELCRVSLPEFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYF 293
Query: 301 GIDGFTNYTRSPAGDIFNPEHHHVHQD-MTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359
+D F + S ++N + V D M PLSHY+I+SSHNTYL GDQ S+S ++ Y
Sbjct: 294 FLDEFVTFLFSKENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAY 353
Query: 360 AWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSI 419
A L+ GCRC+E+DCWDGPDG P+++HG+TLT+KI F DV+ TI ++AF+ +EYPVILSI
Sbjct: 354 ARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSI 413
Query: 420 ENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISE 479
E+HCS+ QQ+ MAQY +LGD L L+ A LPSP LK KIL+K KKL +E
Sbjct: 414 EDHCSIAQQRNMAQYFKKVLGDTL-LTKPVEISADGLPSPNQLKRKILIKHKKL----AE 468
Query: 480 DAEEGEVSDEDSADEIDDDCKLLNG 504
+ EV E D + NG
Sbjct: 469 GSAYEEVPTSMMYSENDISNSIKNG 493
Score = 169 bits (428), Expect = 2e-41
Identities = 111/330 (33%), Positives = 172/330 (52%), Gaps = 27/330 (8%)
Query: 571 RNGRLVVGSFSRRKKKGSKLKKAASVEEG---------DEGQDSPGGQSRGATRQKKTMK 621
+N RL V S S L AA +E + Q + + G +++ K
Sbjct: 890 KNNRLFVFSISMASVAHWSLDVAADSQEELQDWVKKIREVAQTADARLTEGKIMERRK-K 948
Query: 622 LSRALSDLVKYTKSVATHD--IEMEAASSWQVSSFSETKAHQILQQ-KPAQYLRFNQQQL 678
++ LS+LV Y + V + I E A +SSF ETKA + + + K ++L++N+ QL
Sbjct: 949 IALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGKKFLQYNRLQL 1008
Query: 679 SRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGC 738
SRIYP R+DSSNY+P P W G Q+VALN+Q+ + +Q+N+A F CGYVL+P
Sbjct: 1009 SRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGRHCGYVLQPST 1068
Query: 739 MCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPV 798
M F+P + L G + + ++ + LPK RG I+ PFVE+E+ G
Sbjct: 1069 MRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPFVEIEVAGAEY 1121
Query: 799 DCSREQTRVVDDNGFNPTW-EETLVFMVHMPEIALVRFLVWDHDPIG-RDFIGQRTLAFS 856
D ++++T V DNG NP W + F + PE A +RF+V++ D ++F+ Q T
Sbjct: 1122 DSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVK 1181
Query: 857 SMMPGYRHV-----YLEGMEEASIFVHVAV 881
+ GYR V Y E +E AS+ + + +
Sbjct: 1182 GLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 231 bits (590), Expect = 3e-60
Identities = 146/430 (33%), Positives = 228/430 (53%), Gaps = 25/430 (5%)
Query: 78 IRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSH--RESLDL 135
+ W + + + I I+E+ G+ S+ F+R +CCF+I +G+ +L L
Sbjct: 52 VAWSKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSL 111
Query: 136 VSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVL 195
+ S E A W++GL+ L E A + WL++ D+ S+S+ E+
Sbjct: 112 AADSKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELK 167
Query: 196 QLLHKLNVNLPRQR-VKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLL------- 247
+L +N + + +K F E H+ L FE+F FYK + + +L
Sbjct: 168 TILPLINFKVSSAKFLKDKFVEIGA--HKDELSFEQFHLFYKKLMFEQQKSILDEFKKDS 225
Query: 248 MLTYSNHKDHLDAASL-----QRFLQVEQKMAGVT-LESCQDIIEQF-EPCPENKSKGLL 300
+ + D DA+++ QRFL EQ+ L ++ + +F + ++ L
Sbjct: 226 SVFILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFL 285
Query: 301 GIDGFTNYTRSPAGDIFNPEHHHVH-QDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMY 359
+D F Y S I++ ++ V QDM PLSHY+I+SSHNTYL GDQL S+S + Y
Sbjct: 286 FVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAY 345
Query: 360 AWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSI 419
L+ GCRC+E+DCWDGPDG+P+++HG+T T+KI F DV++ I +AF+ + +PVILSI
Sbjct: 346 IRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSI 405
Query: 420 ENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISE 479
E HCSV QQ+ MA+ ++ GD L L+ + A LPSP L+ KI++K KKL
Sbjct: 406 EEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDV 464
Query: 480 DAEEGEVSDE 489
D + DE
Sbjct: 465 DVNMEDKKDE 474
Score = 169 bits (429), Expect = 1e-41
Identities = 102/274 (37%), Positives = 154/274 (56%), Gaps = 25/274 (9%)
Query: 617 KKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQ 676
+K ++ LSDLV Y K + +E ++ SF ETKA I++QKP L++NQ+
Sbjct: 921 EKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQK 980
Query: 677 QLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKP 736
L+R+YP RVDSSNY+P W G QMVALN+Q+ + +Q+N A FS NG GYVL+P
Sbjct: 981 GLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQP 1040
Query: 737 GCMCQGVFNPNSEDPLPGQLKKQ----LVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVE 792
M DP+P + +++ L ++++ + LPK LG I PFVEVE
Sbjct: 1041 ESM-----RTEKYDPMPPESQRKILMTLTVKVLGARHLPK-----LG--RSIACPFVEVE 1088
Query: 793 IIGLPVDCSREQTRVVDDNGFNPTW---EETLVFMVHMPEIALVRFLVWDHDPIG-RDFI 848
I G D ++ +T VV+DNG +P W +E + F ++ P +A +RF+V++ D +F+
Sbjct: 1089 ICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFL 1148
Query: 849 GQRTLAFSSMMPGYRHV-----YLEGMEEASIFV 877
T ++ G+R V Y E +E AS+ V
Sbjct: 1149 AHATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 57.8 bits (138), Expect = 7e-08
Identities = 99/360 (27%), Positives = 121/360 (33%), Gaps = 70/360 (19%)
Query: 901 GPKPGSLDSHAAGRPPARPSVSQR---ILRRTASAPTKSQK-PGRRGFPELVLGTRDTGS 956
G + G + PP RP V + I S P Q P RG P + G R
Sbjct: 156 GHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQ--- 212
Query: 957 KGVADDVVPPGPGPAPEA-PAQEGP--GSGSPRDTRPLSTQRPL---PPLCSLETIAEEP 1010
P PGP P P G G GS R + PLS+ P PPL + A +
Sbjct: 213 ---------PSPGPTPPPFPGNRGTALGGGSIRQS-PLSSSSPFSNRPPLPPTPSRALDD 262
Query: 1011 APGPGPPP---------PAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNG 1061
P P PPP A P +PP P+ P + AS P SRP P
Sbjct: 263 KPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPS-ASSQAPPPPPPPSRPGP--- 318
Query: 1062 EGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAP---FPAP 1118
P S + PR LP S P G PL P P P
Sbjct: 319 -------PPLPPSSSGNDETPR----LPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPP 367
Query: 1119 AVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMG 1178
V S PL VS + S S +LP+ SR + G
Sbjct: 368 PVRDPPGRSGPL-------PPPPPVSRNGSTSR-------ALPATPQLPSRSGVDSPRSG 413
Query: 1179 RLPP-RPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPW 1237
PP P SA P PP + S +R Q P DE + R ++ LP P+
Sbjct: 414 PRPPLPPDRPSAGAPPPPPPSTS-----IRNGFQDSPCEDEWESRFYFHPISDLPPPEPY 468
Score = 57.4 bits (137), Expect = 1e-07
Identities = 103/383 (26%), Positives = 133/383 (34%), Gaps = 62/383 (16%)
Query: 893 GLKGLFLRG-PKPGSL---DSHAAG-RPPARPSVSQRILRRTASAPTKSQKPGRRGFPEL 947
GL GLF G PK S D+ + G RPP P + + S P+ PGR FP
Sbjct: 99 GLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSG---PGR--FPVP 153
Query: 948 VLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIA 1007
G R + + + PP P + + P +PR + R PP +
Sbjct: 154 SPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPP---VPGGP 210
Query: 1008 EEPAPGPGPPP-------------PAAVPTSSS---QGRPPYPTGPGANVASPLEDTEEP 1051
+P+PGP PPP P SSS RPP P P + L+D P
Sbjct: 211 RQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTP----SRALDDKPPP 266
Query: 1052 RDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPL 1111
P P G E P P +P R + Q P P RP
Sbjct: 267 ----PPPPVGNRPSIHREAVPPPPPQNNKPP-----VPSTPRPSASSQAPPPPPPPSRPG 317
Query: 1112 AAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSREN 1171
P P + +D T RL P + SS+ + S L P
Sbjct: 318 PPPLPPSSSGNDET------PRL-PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVR 370
Query: 1172 LAGAHMGRLPPRP-----HSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAP 1226
G LPP P S S A P P + S+S + +G RPP+P +
Sbjct: 371 DPPGRSGPLPPPPPVSRNGSTSRALPATPQL-PSRSGVDSPRSGPRPPLPPDRP------ 423
Query: 1227 RMAGLPFRPPWGCLSLVGVQDCP 1249
AG P PP G QD P
Sbjct: 424 -SAGAPPPPPPSTSIRNGFQDSP 445
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 57.8 bits (138), Expect = 7e-08
Identities = 99/360 (27%), Positives = 121/360 (33%), Gaps = 70/360 (19%)
Query: 901 GPKPGSLDSHAAGRPPARPSVSQR---ILRRTASAPTKSQK-PGRRGFPELVLGTRDTGS 956
G + G + PP RP V + I S P Q P RG P + G R
Sbjct: 156 GHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPPVPGGPRQ--- 212
Query: 957 KGVADDVVPPGPGPAPEA-PAQEGP--GSGSPRDTRPLSTQRPL---PPLCSLETIAEEP 1010
P PGP P P G G GS R + PLS+ P PPL + A +
Sbjct: 213 ---------PSPGPTPPPFPGNRGTALGGGSIRQS-PLSSSSPFSNRPPLPPTPSRALDD 262
Query: 1011 APGPGPPP---------PAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNG 1061
P P PPP A P +PP P+ P + AS P SRP P
Sbjct: 263 KPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPS-ASSQAPPPPPPPSRPGP--- 318
Query: 1062 EGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAP---FPAP 1118
P S + PR LP S P G PL P P P
Sbjct: 319 -------PPLPPSSSGNDETPR----LPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPP 367
Query: 1119 AVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMG 1178
V S PL VS + S S +LP+ SR + G
Sbjct: 368 PVRDPPGRSGPL-------PPPPPVSRNGSTSR-------ALPATPQLPSRSGVDSPRSG 413
Query: 1179 RLPP-RPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPW 1237
PP P SA P PP + S +R Q P DE + R ++ LP P+
Sbjct: 414 PRPPLPPDRPSAGAPPPPPPSTS-----IRNGFQDSPCEDEWESRFYFHPISDLPPPEPY 468
Score = 57.4 bits (137), Expect = 1e-07
Identities = 103/383 (26%), Positives = 133/383 (34%), Gaps = 62/383 (16%)
Query: 893 GLKGLFLRG-PKPGSL---DSHAAG-RPPARPSVSQRILRRTASAPTKSQKPGRRGFPEL 947
GL GLF G PK S D+ + G RPP P + + S P+ PGR FP
Sbjct: 99 GLGGLFQAGMPKLRSTANRDNDSGGSRPPLLPPGGRSTSAKPFSPPSG---PGR--FPVP 153
Query: 948 VLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIA 1007
G R + + + PP P + + P +PR + R PP +
Sbjct: 154 SPGHRSGPPEPQRNRMPPPRPDVGSKPDSIPPPVPSTPRPIQSSPHNRGSPP---VPGGP 210
Query: 1008 EEPAPGPGPPP-------------PAAVPTSSS---QGRPPYPTGPGANVASPLEDTEEP 1051
+P+PGP PPP P SSS RPP P P + L+D P
Sbjct: 211 RQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPPTP----SRALDDKPPP 266
Query: 1052 RDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPL 1111
P P G E P P +P R + Q P P RP
Sbjct: 267 ----PPPPVGNRPSIHREAVPPPPPQNNKPP-----VPSTPRPSASSQAPPPPPPPSRPG 317
Query: 1112 AAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSREN 1171
P P + +D T RL P + SS+ + S L P
Sbjct: 318 PPPLPPSSSGNDET------PRL-PQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVR 370
Query: 1172 LAGAHMGRLPPRP-----HSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAP 1226
G LPP P S S A P P + S+S + +G RPP+P +
Sbjct: 371 DPPGRSGPLPPPPPVSRNGSTSRALPATPQL-PSRSGVDSPRSGPRPPLPPDRP------ 423
Query: 1227 RMAGLPFRPPWGCLSLVGVQDCP 1249
AG P PP G QD P
Sbjct: 424 -SAGAPPPPPPSTSIRNGFQDSP 445
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 57.0 bits (136), Expect = 1e-07
Identities = 98/387 (25%), Positives = 143/387 (36%), Gaps = 64/387 (16%)
Query: 889 KQALGLKGLFLRGPKPGSLDSHAAG----RPPARPSVSQRILRRTASAPTKSQKPGRRGF 944
++A G+ G + P + + +AG P +RP S R R + P K+ PG
Sbjct: 60 ERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGER---APPAKNTSPGPVSS 116
Query: 945 PELVLGTR---DTGSKGV---ADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLP 998
P GT G KG+ A++ V G A EAP + +G+ RDT + P P
Sbjct: 117 PGRASGTTRPGPLGQKGLRISAEETV--ARGKATEAPKRSALSAGARRDTSGPTPGTPSP 174
Query: 999 PLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLE--DTEEPRDSRP 1056
+ A P P P S++ RPP GP +V+S E TE +R
Sbjct: 175 AMARRSRAAGTEVGLPRPAP-------SARPRPP-TEGPRKSVSSASEHSTTEPSPAARR 226
Query: 1057 RPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPL-GGWRPLAAPF 1115
RP G G R+ S S P G P R P++P G + L P
Sbjct: 227 RPSAGGGLQRPASRSLSSSATPLSSPARSG--PSARGTPRAPAHPSQPKPKGLQALRPPQ 284
Query: 1116 PAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSR-----E 1170
P +D+ + +SSS L+ PS ++R +
Sbjct: 285 VTPP-------------------RKDAAPALGPLSSS----PLATPSPSGTKARPVPPPD 321
Query: 1171 NLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAG 1230
N A LPP P P P+ + +P+ + Q P P P P M
Sbjct: 322 NAATPLPATLPPSP-------PLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTT 374
Query: 1231 LPFRPPWGCLSLVGVQDCPVAAKSKSL 1257
P + P ++ +Q P + S SL
Sbjct: 375 PPMQAPPSLQTIPPIQ-VPHSLTSPSL 400
Score = 49.3 bits (116), Expect = 3e-05
Identities = 90/368 (24%), Positives = 127/368 (34%), Gaps = 78/368 (21%)
Query: 901 GPKPGSLD------SHAAGR--------PPARPSVSQRILRRTASAP----TKSQKPGRR 942
GP PG+ S AAG P ARP R++ S+ T P R
Sbjct: 166 GPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR 225
Query: 943 GFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGS-GSPR------DTRPLSTQR 995
P G + S+ ++ P +PA+ GP + G+PR +P Q
Sbjct: 226 RRPSAGGGLQRPASRSLSSSATPLS------SPARSGPSARGTPRAPAHPSQPKPKGLQA 279
Query: 996 PLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSR 1055
PP + PA GP P A P+ S P P P N A+PL T P
Sbjct: 280 LRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVP--PPDNAATPLPATLPPSPPL 337
Query: 1056 PRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPF 1115
P AP S S P +L LP P P P AP
Sbjct: 338 ATP---------LPLAPPSP----SAPPSLQTLP---------SPPATP-----PSQAP- 369
Query: 1116 PAPAVYSDATGSDPLWQRLEPCGHRDSVSSSS--------SMSSSDTVIDLSLPSLGLGR 1167
P++ + + P Q + P S++S S ++SS L P+L
Sbjct: 370 --PSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATH 427
Query: 1168 SRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPR 1227
S ++ P ++ PD PP+ S P PP+ L P +++P
Sbjct: 428 SFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLP------ASPPLQTSLSP-AVSPL 480
Query: 1228 MAGLPFRP 1235
+ L P
Sbjct: 481 SSPLTIHP 488
Score = 40.0 bits (92), Expect = 0.016
Identities = 114/469 (24%), Positives = 152/469 (32%), Gaps = 77/469 (16%)
Query: 965 PPGP--GPAPEAPAQEG--PGSGSPRDTRPLSTQRPLPPLCSLET--------IAEEPAP 1012
PP P P PE P+ P P P P PPL L T +A P
Sbjct: 572 PPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQ 631
Query: 1013 GPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAP 1072
P P PPA+ P S P P P A L+ P S P + A
Sbjct: 632 AP-PSPPASPPLSPLA--TPSPQAPNALAVHLLQAPFSPPPSPP--VQAPFSPPASPPVS 686
Query: 1073 GSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQ 1132
S T P +L P+ QVP P A+P +P+ PL
Sbjct: 687 PSATPPSQAPPSLAAPPL--------QVPPSPP------ASPPMSPSATPPPQAPPPL-- 730
Query: 1133 RLEPCGHRDSVSSSSSMSSSDTVID-----LSLPSLGLGRSRE-NLAGAHMGRLPPRPHS 1186
P S +S MS S T L+ P L + S +L + + + PP+
Sbjct: 731 AAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPP 790
Query: 1187 ASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQ 1246
A A P ++ +P GQ P P P S P P PP L+ V
Sbjct: 791 ALATPP-----LQALPSPPASFPGQAPFSPSASLPMS--PLATPPPQAPPVLAAPLLQVP 843
Query: 1247 DCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGP--------GVRRDT 1298
P A+ + L A P+ PG VSGP G
Sbjct: 844 PSPPASPT-----LQAPRRPPT--------------PGPDTSVSGPRLTLALAPGPPPPP 884
Query: 1299 LTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIA----SRAR 1354
L+ AG +S TS G GP +S + + A SR
Sbjct: 885 SRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGP 944
Query: 1355 QAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGP 1403
+ G PP G+ +G C++ ++ P+ GAL P
Sbjct: 945 APPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDP 993
Score = 34.3 bits (77), Expect = 0.87
Identities = 60/256 (23%), Positives = 85/256 (33%), Gaps = 32/256 (12%)
Query: 991 LSTQRPLPPLCSLETIAEEPAPGPGPP----PPAAVPTSSSQGRPPYPTGPGANVASPLE 1046
L++ P PL SL E PP PPA++ T + P P ++PL
Sbjct: 495 LASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLT 554
Query: 1047 DTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLG 1106
P PC + P + P P + +G +P+ PL
Sbjct: 555 TPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAP-PALASPPLQG-LPSPPLS 612
Query: 1107 GWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLG 1166
PLA P P P L P S +S +S T + +L +
Sbjct: 613 ---PLATPPP----------QAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAV- 658
Query: 1167 RSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATG------QRPPIPDELQ 1220
+L A P P A + P PPV+ S + P+ Q PP P
Sbjct: 659 ----HLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 714
Query: 1221 PRSLAPRMAGLPFRPP 1236
P ++P P PP
Sbjct: 715 P--MSPSATPPPQAPP 728
Score = 34.3 bits (77), Expect = 0.87
Identities = 131/554 (23%), Positives = 173/554 (31%), Gaps = 98/554 (17%)
Query: 899 LRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKS-QKPGRRGFPELVLGTRDTGSK 957
L P P + S A P A P+++ L+ S P P + P L L
Sbjct: 576 LTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPS 635
Query: 958 GVADDVVPPGPGPAPEAPAQ------EGPGSG----------SPRDTRPLSTQRP----L 997
A + P P+P+AP + P S SP + P+S
Sbjct: 636 PPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQA 695
Query: 998 PPLCSLETIAEEPAPGPGPP------PPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEP 1051
PP + + P+P PP PP P + PP P + P+ + P
Sbjct: 696 PPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLA--APPLQVPPSPPASPPMSPSATP 753
Query: 1052 RDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVP----TEPLGG 1107
P AP Q P LP+ K Q P T PL
Sbjct: 754 PPRVP----------PLLAAPPLQV----PPSPPASLPMSPLAKPPPQAPPALATPPLQA 799
Query: 1108 WRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGR 1167
A FP A +S S+S MS T + P L
Sbjct: 800 LPSPPASFPGQAPFSP--------------------SASLPMSPLATPPPQAPPVL---- 835
Query: 1168 SRENLAGAHMGRLPPRPHSA----SAARPDLPPVTKSKSNPNLR-ATGQRPPIPDELQPR 1222
A + ++PP P ++ + RP P S S P L A PP P P
Sbjct: 836 ------AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS 889
Query: 1223 SL--APRMAGLPFRPPWGCLSLVGVQDCP---VAAKSKSLGDLTADDFAPSFEGGSRRLS 1277
S P +AG L G P AA +L A A G + L+
Sbjct: 890 STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA 949
Query: 1278 HSLGLPGGT---RRVSGPGVRRD--TLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGP 1332
G PG +GPG T+ E + G + S G +G A G
Sbjct: 950 FR-GAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGA 1008
Query: 1333 GFVRRSSSRSHSRVRAIASRARQAQERQQRLQG----LGRQGPPEEERGTPEGACSVGHE 1388
G S S +R+ + A QA Q L +G G P GA G
Sbjct: 1009 GAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVT 1068
Query: 1389 GSVDAPAPSKGALG 1402
G A A S LG
Sbjct: 1069 GGARA-ALSDAELG 1081
>gi|91208420 bassoon protein [Homo sapiens]
Length = 3926
Score = 55.8 bits (133), Expect = 3e-07
Identities = 49/177 (27%), Positives = 61/177 (34%), Gaps = 15/177 (8%)
Query: 958 GVADDVVPPG---PGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGP 1014
G D +PPG PGP P GPG+G P Q P + P PGP
Sbjct: 10 GAGDGPLPPGGAGPGPGPGP----GPGAGKPPSAPAGGGQLPAAGAARSTAVPPVPGPGP 65
Query: 1015 GPPPPAAVPTSSSQGRPPYPTGPGANVASPL---EDTEEPRDSRPRPCNGEGAGGAYERA 1071
GP P ++S + P P G ASP P PR +G G
Sbjct: 66 GPGPGPGPGSTSRRLDPKEPLG-NQRAASPTPKQASATTPGHESPRETRAQGPAGQEADG 124
Query: 1072 PGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSD 1128
P S+ + G P + G PT P P AP P+ + SD
Sbjct: 125 PRRTLQVDSRTQRSGRSPSVS--PDRGSTPTSPYS--VPQIAPLPSSTLCPICKTSD 177
Score = 36.2 bits (82), Expect = 0.23
Identities = 44/159 (27%), Positives = 63/159 (39%), Gaps = 31/159 (19%)
Query: 916 PARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPG------ 969
PA P+ S+R +++A + P T + G + +P P
Sbjct: 1400 PASPAGSERSPSPSSTAHSYGHSP-------------TTANYGSQTEDLPQAPSGLAAAG 1446
Query: 970 -PAPEAP--AQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSS 1026
A E P A +G G G+P+ +R S P S + +E P PG P A S
Sbjct: 1447 RAAREKPLSASDGEG-GTPQPSRAYSYFASSSPPLSPSSPSESPTFSPGKMGPRATAEFS 1505
Query: 1027 SQGRPP-----YPTGPGANVASPL--EDTEEP-RDSRPR 1057
+Q P P PGA SP+ + T+ P R S PR
Sbjct: 1506 TQTPSPAPASDMPRSPGAPTPSPMVAQGTQTPHRPSTPR 1544
Score = 35.8 bits (81), Expect = 0.30
Identities = 44/157 (28%), Positives = 55/157 (35%), Gaps = 20/157 (12%)
Query: 933 PTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAP----AQEGPGSGSPRDT 988
PT Q P G P GT KG P GP PA +P A P SP+
Sbjct: 534 PTSQQPPV--GAPHRASGTSPLKQKGPQGLGQPSGPLPAKASPLSTKASPLPSKASPQ-A 590
Query: 989 RPLSTQRPLPPLCSLE-------TIAEE-PAPGPGPPPPAAVPTSSSQGRPPYPTGPGAN 1040
+PL P S++ T AE P P P P A P S R P P
Sbjct: 591 KPLRASEPSKTPSSVQEKKTRVPTKAEPMPKPPPETTPTPATPKVKSGVRRAEPATPVVK 650
Query: 1041 VASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTD 1077
E D +P + + + R+P S +D
Sbjct: 651 AVPEAPKGGEAEDLVGKPYSQDAS-----RSPQSLSD 682
Score = 34.7 bits (78), Expect = 0.67
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 9/58 (15%)
Query: 932 APTKSQKPGRRGFPELVLG--TRDTGSKGVADDVVPPGPGPAP----EAPAQEGPGSG 983
A T+ Q +G P++V +++ G K + PGPGPAP E A+ GPGSG
Sbjct: 371 ADTQGQPAPSKGTPKIVFNDASKEAGPKPLGSG---PGPGPAPGAKTEPGARMGPGSG 425
Score = 32.0 bits (71), Expect = 4.3
Identities = 52/202 (25%), Positives = 65/202 (32%), Gaps = 36/202 (17%)
Query: 880 AVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKP 939
A+S KQ LG KP S G P +P Q R S P P
Sbjct: 246 ALSPAHSPAKQPLG---------KPDQERSRGPGGP--QPGSRQAETARATSVPG----P 290
Query: 940 GRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGP----GSGSPRDTRPLSTQR 995
+ P V + P P PA EAPA+ G G+ T+ T +
Sbjct: 291 AQAAAPPEVGRVSPQPPQPTKPSTAEPRP-PAGEAPAKSATAVPAGLGATEQTQEGLTGK 349
Query: 996 PLPPLCSLETIAE-------------EPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVA 1042
SL T A +PAP G P S G P +GPG
Sbjct: 350 LFGLGASLLTQASTLMSVQPEADTQGQPAPSKGTPKIVFNDASKEAGPKPLGSGPG---P 406
Query: 1043 SPLEDTEEPRDSRPRPCNGEGA 1064
P + +R P +G GA
Sbjct: 407 GPAPGAKTEPGARMGPGSGPGA 428
Score = 31.2 bits (69), Expect = 7.4
Identities = 21/78 (26%), Positives = 33/78 (42%), Gaps = 7/78 (8%)
Query: 1007 AEEPAPGPGPPPPAAVPTSSSQGRPPYPTGP-------GANVASPLEDTEEPRDSRPRPC 1059
A APG G P +P +++ P T P GA +PL + P D+ P
Sbjct: 2286 AAAKAPGAGGPSRPEMPVGAAREEPLPTTTPAAIKEAAGAPAPAPLAGQKPPADAAPGGG 2345
Query: 1060 NGEGAGGAYERAPGSQTD 1077
+G + +E+ SQ +
Sbjct: 2346 SGALSRPGFEKEEASQEE 2363
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 53.9 bits (128), Expect = 1e-06
Identities = 83/338 (24%), Positives = 121/338 (35%), Gaps = 74/338 (21%)
Query: 931 SAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRP 990
SAP K Q + P + + G ++ PPG PAP AP+
Sbjct: 1346 SAPYKDQLSSKEQ-PSFLASQQLLSQAGPSN---PPGAPPAPLAPSS------------- 1388
Query: 991 LSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANV--ASPLEDT 1048
PP+ +L PA P P + T+S G P P G + + + PL +T
Sbjct: 1389 -------PPVTALPQDGAAPATSTMPEPASG--TASQAGGPGTPQGLTSELETSQPLAET 1439
Query: 1049 EE-------------PRDSRPRPCNGEGAGGAYERAP----------GSQTDGRSQPRTL 1085
E P P + A E P G+ QP L
Sbjct: 1440 HEAPLAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEPSPHSGTPQPALGQPAPL 1499
Query: 1086 GHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDP-----------LWQRL 1134
V + Q+P+ PLG P P P A+ SD G P L ++L
Sbjct: 1500 LPAAVGAVSLATSQLPSPPLG---PTVPPQPPSALESDGEGPPPRVGFVDSTIKSLDEKL 1556
Query: 1135 EPCGHRDSVSSSSSMSSSDTVI---DLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAAR 1191
+++ V +SS+ + + + D +L L + R + G + LPP P A + R
Sbjct: 1557 RTLLYQEHVPTSSASAGTPVEVGDRDFTLEPLRGDQPRSEVCGGDLA-LPPVPKEAVSGR 1615
Query: 1192 PDLPP--VTKSKSNPNLRAT---GQRPPIPDELQPRSL 1224
LP V KS+ P A G + E PRS+
Sbjct: 1616 VQLPQPLVEKSELAPTRGAVMEQGTSSSMTAESSPRSM 1653
Score = 44.3 bits (103), Expect = 8e-04
Identities = 109/492 (22%), Positives = 161/492 (32%), Gaps = 106/492 (21%)
Query: 963 VVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAV 1022
V+PP P P P Q P P PL+ PLP + +A +P P PP
Sbjct: 709 VLPPPSTPMPTGPGQPAPPGQQPP---PLAQPTPLP-----QVLAPQPVVPLQPVPPHLP 760
Query: 1023 P--TSSSQGRPPYPTGPGANVASPLEDTEEPRDSRP--------RPCNG-EGAGGAYERA 1071
P +SQ P P +PL+ + P P G +G A
Sbjct: 761 PYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPPALPDL 820
Query: 1072 PGSQTDGRSQPRTLGHLPVIRRVKS-----EGQVPTEPLGGWRPLAAPFPAPA--VYSDA 1124
P + P+ ++ + + +P + + P AP P + +A
Sbjct: 821 PTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNA 880
Query: 1125 TGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLG-------RSRENL-AGAH 1176
+ PL P S+ S+ + V + P + + +N+ A
Sbjct: 881 PATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPP 940
Query: 1177 MGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIP-----DELQPRSLAPRMAGL 1231
LPP+P +P LPP P L RPP P L P+ + P L
Sbjct: 941 QPALPPQP--TLPPQPVLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPAL 998
Query: 1232 PFRPPW---------------GCLSLVG---------------VQDCPVAAKSKSLGDL- 1260
P RP G L+G V P A S L ++
Sbjct: 999 PVRPEPLQPHLPEQAAPAATPGSQILLGHPAPYAVDVAAQVPTVPVPPAAVLSPPLPEVL 1058
Query: 1261 --TADDFAPSFEGGSRRLSHSL-GLPGGTRRV---------SGPGVRRDTLTEQLRWLTV 1308
A + P F +S S+ +P T + GPG+ T QL V
Sbjct: 1059 LPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCPTVQLTVEPV 1118
Query: 1309 FQQ------------------AGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIA 1350
++ D+TS L + EG GG R++ + H R +
Sbjct: 1119 QEEQASQDKPPGLPQSCESYGGSDVTSGKELSDSCEGAFGGGRLEGRAARKHHRR----S 1174
Query: 1351 SRARQAQERQQR 1362
+RAR QER R
Sbjct: 1175 TRARSRQERASR 1186
Score = 36.6 bits (83), Expect = 0.18
Identities = 69/299 (23%), Positives = 102/299 (34%), Gaps = 42/299 (14%)
Query: 968 PG-PAPEAPAQEGPGSGSPRDTRPLSTQRPL--PPLCSLETIAEEPAPGPGPPPPAAVPT 1024
PG P PA P S P + P+ PP + T +PAP PPP A PT
Sbjct: 679 PGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPT 738
Query: 1025 SSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQ-PR 1083
Q P P P V L P P + + P + +Q P
Sbjct: 739 PLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKPL-----QMPQAPLQPLAQVPP 793
Query: 1084 TLGHLPVIRRVKSEGQVPTEPLGGWRP--------LAAPFPAPAVYSDATGSDPLWQRLE 1135
+ +PV+ + P + G P P P P +S A L L
Sbjct: 794 QMPPIPVVPPI-----TPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLP 848
Query: 1136 PCG-----------HRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAH--MGRLPP 1182
P H + + ++P L + H + +LP
Sbjct: 849 PASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPG 908
Query: 1183 RPHSASA----ARPDLPPVTKSKSNPNLRATGQRPPIPDE--LQPRSLAPRMAGLPFRP 1235
+P +A A D+PP + + N+RAT +P +P + L P+ + P LP +P
Sbjct: 909 QPVYPAAFPQMAPTDVPP-SPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQP 966
Score = 35.8 bits (81), Expect = 0.30
Identities = 57/224 (25%), Positives = 75/224 (33%), Gaps = 22/224 (9%)
Query: 907 LDSHAAGRPPARPSVSQRILR------RTASAPTKSQKPGRRG-FPELVLGTRDTGSKGV 959
L S AA PPA P++ + ++ + P ++ P P L + + +
Sbjct: 840 LPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSI 899
Query: 960 ADDVVP-PGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPP 1018
V PG P A Q P P + R PP +L P PP
Sbjct: 900 HSAVAQLPGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQ 959
Query: 1019 PAAVP---TSSSQGRPPYPTGPGANV--ASPLEDTEEPRDSRPRPCNGEGAGGAYERA-P 1072
P P RPP P P + P+ + RP P A A P
Sbjct: 960 PTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQPHLPEQAAPAATP 1019
Query: 1073 GSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFP 1116
GSQ LGH P V QVPT P+ L+ P P
Sbjct: 1020 GSQI-------LLGH-PAPYAVDVAAQVPTVPVPPAAVLSPPLP 1055
Score = 34.3 bits (77), Expect = 0.87
Identities = 25/91 (27%), Positives = 34/91 (37%), Gaps = 4/91 (4%)
Query: 965 PPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLP-PLCSLETIAEEPAPGPGPPPPAAVP 1023
P P PA PG+ + P+ TQ P P P+ + + PAP GP AA
Sbjct: 93 PAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAA--AVETAPAPDGGPREEAAAT 150
Query: 1024 T-SSSQGRPPYPTGPGANVASPLEDTEEPRD 1053
+G PG E+ E+ D
Sbjct: 151 VRKEDEGAAEAKPEPGRTRRDEPEEEEDDED 181
Score = 33.9 bits (76), Expect = 1.1
Identities = 41/139 (29%), Positives = 55/139 (39%), Gaps = 21/139 (15%)
Query: 940 GRRGFPELVLGT-RDTGSKGVADDVVPPG-PGP-------APEAPAQEGPG---SGSPRD 987
GRR P ++ R G G+A+ PGP E+ +E PG + +P
Sbjct: 6 GRRDVPGTLMEPGRGAGPAGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGP 65
Query: 988 TRPLSTQRPLPPLCSLETIAEEPAPG-PGPPPPAA-VPTSSSQGRP----PYPTG---PG 1038
P QR + LC + E A G P P PAA V + G P P P G PG
Sbjct: 66 QPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPG 125
Query: 1039 ANVASPLEDTEEPRDSRPR 1057
+ + +T D PR
Sbjct: 126 PDPIAAAVETAPAPDGGPR 144
Score = 32.3 bits (72), Expect = 3.3
Identities = 31/106 (29%), Positives = 42/106 (39%), Gaps = 19/106 (17%)
Query: 1151 SSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPR----------PHSASAARPDLPPV-TK 1199
S V+ SLPSLG + G +G +P P A + P LPP T
Sbjct: 657 SEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTP 716
Query: 1200 SKSNPNLRAT-GQRPP-------IPDELQPRSLAPRMAGLPFRPPW 1237
+ P A GQ+PP +P L P+ + P P PP+
Sbjct: 717 MPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPY 762
>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
Length = 464
Score = 53.9 bits (128), Expect = 1e-06
Identities = 53/193 (27%), Positives = 64/193 (33%), Gaps = 30/193 (15%)
Query: 894 LKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRD 953
+ GL R P P SL G P P + P S PG P G
Sbjct: 238 MNGLPPRPPLPESLPPPPPGGLPLPPM--------PPTGPAPSGPPGPPQLPPPAPGVHP 289
Query: 954 ---------TGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLE 1004
+G A V PP PG P AP P SG P P +
Sbjct: 290 PAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSG---------VHPPAPGVHPPA 340
Query: 1005 TIAEEPAPGPGPPPPAAVPTSSSQGRPP----YPTGPGANVASPLEDTEEPRDSRPRPCN 1060
PAPG PP P P + PP +P PG + A+P + P P P
Sbjct: 341 PGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGM 400
Query: 1061 GEGAGGAYERAPG 1073
A G + + PG
Sbjct: 401 HPQAPGVHPQPPG 413
Score = 44.7 bits (104), Expect = 6e-04
Identities = 50/169 (29%), Positives = 55/169 (32%), Gaps = 23/169 (13%)
Query: 965 PPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPG--PGPPPPAAV 1022
PP P P P PG P P LPP L P PG P PP P
Sbjct: 217 PPAPPSLPAGP----PGVKRP----PPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTG 268
Query: 1023 PTSSSQGRPPY--PTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS 1080
P S PP P PG + +P+ P P A G + APG
Sbjct: 269 PAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPG------V 322
Query: 1081 QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDP 1129
P T G P V P G P PAP V+ A G P
Sbjct: 323 HPPTSGVHPPAPGVHPPAPGVHPPAPGVHP-----PAPGVHPPAPGVHP 366
Score = 32.3 bits (72), Expect = 3.3
Identities = 20/55 (36%), Positives = 23/55 (41%), Gaps = 8/55 (14%)
Query: 1181 PPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRP 1235
PP P S A PP K P + RPP+P+ L P P GLP P
Sbjct: 217 PPAPPSLPAG----PPGVKRPPPPLMNGLPPRPPLPESLPP----PPPGGLPLPP 263
Score = 32.0 bits (71), Expect = 4.3
Identities = 31/117 (26%), Positives = 38/117 (32%), Gaps = 14/117 (11%)
Query: 902 PKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVAD 961
P PG +AG P P V A+ Q PG + G A
Sbjct: 360 PAPGVHPPPSAGVHPQAPGV------HPAAPAVHPQAPG--------VHPPAPGMHPQAP 405
Query: 962 DVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPP 1018
V P PG P AP G + P+PP+ +E P P PPP
Sbjct: 406 GVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPP 462
>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
Length = 639
Score = 53.5 bits (127), Expect = 1e-06
Identities = 81/307 (26%), Positives = 111/307 (36%), Gaps = 71/307 (23%)
Query: 973 EAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPP 1032
EAP GS S T PL++ P P AP PPPP+ + S++Q RPP
Sbjct: 322 EAPVPASVGSTSGPATTPLASA-PRPA-----------APANNPPPPSLM--STTQSRPP 367
Query: 1033 Y------------------PTGPGANVAS---PLEDTEEPRDSRPRPCNGEGAGGAYERA 1071
+ P GPG S PL P N G + +
Sbjct: 368 WMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQP 427
Query: 1072 P------GSQTDGRSQP----RTLGHLP----VIRRVKSEGQVPTEPLGGWRPLAAPFPA 1117
P G G P + LG P V R + +G +P P+G P P P
Sbjct: 428 PPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPP---PPPP 484
Query: 1118 PAVYSDATGSDPL--WQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGA 1175
P+ S PL WQ+ + SSS SS+ P + A
Sbjct: 485 PSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASST--------PLPWQQNTTTTTTSA 536
Query: 1176 HMGRLPP--RPHSASAARPDLPPVTKSKSNPNL--RATGQRPPIPDEL--QPRSLAPRMA 1229
G +PP + +A+AA P P + + NP + G +PP+P P P A
Sbjct: 537 GTGSIPPWQQQQAAAAASPGAP---QMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSA 593
Query: 1230 GLPFRPP 1236
G+ + PP
Sbjct: 594 GMMYAPP 600
Score = 35.8 bits (81), Expect = 0.30
Identities = 55/245 (22%), Positives = 79/245 (32%), Gaps = 31/245 (12%)
Query: 902 PKPGSLDSHAAGRPP---ARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKG 958
P P SL S RPP + PS S+ P G FP L + G G
Sbjct: 353 PPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPG-GPGGGPHSFPH-PLPSLTGGHGG 410
Query: 959 VADDVVPPGPGPA----PEAPAQEGPGSGSPRDTRPLST-------------------QR 995
P GP P P P +GP P+
Sbjct: 411 HPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMM 470
Query: 996 PLPPLCSLETIAEEPAPGPGPPPPAAVPT-SSSQGRPPYPTGPGANVASPLEDTEEPRDS 1054
P PP+ + P+ P PPP +P Q +PP P P +++AS + +
Sbjct: 471 PPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTT 530
Query: 1055 RPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAP 1114
G G+ +++ + P+ G+ ++ G P P G P P
Sbjct: 531 TTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMV--PLPPGVQPPLPPGAPPPPPPP 588
Query: 1115 FPAPA 1119
P A
Sbjct: 589 PPGSA 593
Score = 32.7 bits (73), Expect = 2.5
Identities = 37/137 (27%), Positives = 47/137 (34%), Gaps = 24/137 (17%)
Query: 912 AGRPPARPSV-----SQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPP 966
+G+PP PS Q+ + P S P T T S G +PP
Sbjct: 486 SGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGS--IPP 543
Query: 967 ------GPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA 1020
+P AP +G + P P Q PLPP P P P PPP +
Sbjct: 544 WQQQQAAAAASPGAPQMQGNPTMVPL---PPGVQPPLPP--------GAPPPPPPPPPGS 592
Query: 1021 AVPTSSSQGRPPYPTGP 1037
A + PP P P
Sbjct: 593 AGMMYAPPPPPPPPMDP 609
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,300,875
Number of Sequences: 37866
Number of extensions: 3738621
Number of successful extensions: 28130
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 210
Number of HSP's successfully gapped in prelim test: 1564
Number of HSP's that attempted gapping in prelim test: 16678
Number of HSP's gapped (non-prelim): 8209
length of query: 1416
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1301
effective length of database: 13,892,928
effective search space: 18074699328
effective search space used: 18074699328
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.