Search of human proteins with 78217386

Search of human proteins with 78217386

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|78217386 RAB GTPase activating protein 1-like isoform A
[Homo sapiens]
         (815 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo...  1638   0.0  
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]          1048   0.0  
gi|68299759 ecotropic viral integration site 5 [Homo sapiens]         246   6e-65
gi|229577000 ecotropic viral integration site 5-like isoform 1 [...   244   2e-64
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H...   244   2e-64
gi|114688046 TBC1 domain family, member 4 [Homo sapiens]              201   2e-51
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member...   182   1e-45
gi|13994322 TBC1 domain family, member 10A [Homo sapiens]             155   1e-37
gi|38348348 TBC1 domain family, member 10C [Homo sapiens]             147   4e-35
gi|167614488 TBC1 domain family, member 10B [Homo sapiens]            146   7e-35
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]              115   2e-25
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]            115   2e-25
gi|156231067 TBC1 domain family, member 8 [Homo sapiens]              112   2e-24
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso...   111   2e-24
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso...   111   2e-24
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]   111   3e-24
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]   111   3e-24
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho...   110   5e-24
gi|29648315 small G protein signaling modulator 3 [Homo sapiens]      108   3e-23
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]   106   8e-23
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]   106   8e-23
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]   106   8e-23
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso...   106   1e-22
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]    101   3e-21
gi|148806902 TBC1 domain family, member 12 [Homo sapiens]             100   4e-21
gi|222352143 TBC1 domain family, member 2 [Homo sapiens]               86   1e-16
gi|109638751 ubiquitin specific protease 6 [Homo sapiens]              79   2e-14
gi|226693407 TBC1 domain family, member 3H [Homo sapiens]              78   4e-14
gi|157502205 TBC1 domain family, member 3G [Homo sapiens]              78   4e-14
gi|14149985 TBC1 domain family, member 3F [Homo sapiens]               77   5e-14

>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
           sapiens]
          Length = 815

 Score = 1638 bits (4242), Expect = 0.0
 Identities = 815/815 (100%), Positives = 815/815 (100%)

Query: 1   MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAME 60
           MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAME
Sbjct: 1   MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADDNSTKHEEKPQLKIVSNGDEQLEKAME 60

Query: 61  EILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSP 120
           EILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSP
Sbjct: 61  EILRDSEKRPSSLLVDCQSSSEISDHSFGDIPASQTNKPSLQLILDPSNTEISTPRPSSP 120

Query: 121 GGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSV 180
           GGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSV
Sbjct: 121 GGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQYPFPVTLYVPNVPEGSV 180

Query: 181 RIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAV 240
           RIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAV
Sbjct: 181 RIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIHVFSCEIKEAV 240

Query: 241 SRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDK 300
           SRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDK
Sbjct: 241 SRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDK 300

Query: 301 FYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDG 360
           FYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDG
Sbjct: 301 FYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVKNSDMHLLDMESMGKSYDG 360

Query: 361 RAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPAN 420
           RAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPAN
Sbjct: 361 RAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVRFLLETVVRVYPAN 420

Query: 421 ERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMS 480
           ERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMS
Sbjct: 421 ERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMS 480

Query: 481 PQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVP 540
           PQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVP
Sbjct: 481 PQDDEAEEESDNELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVP 540

Query: 541 EALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQ 600
           EALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQ
Sbjct: 541 EALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQ 600

Query: 601 ESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNF 660
           ESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNF
Sbjct: 601 ESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNF 660

Query: 661 EDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL 720
           EDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL
Sbjct: 661 EDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL 720

Query: 721 LCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIK 780
           LCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIK
Sbjct: 721 LCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIK 780

Query: 781 VPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL 815
           VPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL
Sbjct: 781 VPTKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL 815


>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
          Length = 1069

 Score = 1048 bits (2709), Expect = 0.0
 Identities = 533/842 (63%), Positives = 658/842 (78%), Gaps = 34/842 (4%)

Query: 1   MEVRASLQKVSGSSDSVATMNSEEFVLVPQYADD----NSTKHEEKPQLKIVSNGDEQ-L 55
           M+ +AS+ K+S SSDSV+T+NSE+FVLV +  D+    N+   +EK  LKIV NG EQ L
Sbjct: 1   MDDKASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDDEKTGLKIVGNGSEQQL 60

Query: 56  EKAMEEILRDS--EKRPSSLLV----------DCQSSSEISDHS-FGDIPASQTNKPSLQ 102
           +K + ++L D   + +P    +          D   S+++S  S    +P     KP + 
Sbjct: 61  QKELADVLMDPPMDDQPGEKELVKRSQLDGEGDGPLSNQLSASSTINPVPLVGLQKPEMS 120

Query: 103 LILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSS 162
           L + P   +     P +P  + +EDSV+F+KLTYLGC  V++PR+EVEALR M+ ++S  
Sbjct: 121 LPVKPGQGDSEASSPFTP--VADEDSVVFSKLTYLGCASVNAPRSEVEALRMMSILRSQC 178

Query: 163 QYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSH 222
           Q    VTL VPNV EG VR++D  +N EIA++PIYK+LFC RGHDGT ES+CFAFTES +
Sbjct: 179 QISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAFTESHY 238

Query: 223 GSEEFQIHVFSCEIKEAVSRILYSFCTAFKRSSRQVSDVKDSVIPTPDSDVFTFSVSLEV 282
            +E F+IHVF CEI+EAVSRILYSF TAF+RS++Q      +   TPDSD+FTFSVSLE+
Sbjct: 239 NAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEI 298

Query: 283 KEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVK 342
           KEDDGKG FS VPKD+D+  FKL+QGI+KK+VI VQQ +NKELAIERCFG+LLSPG++V+
Sbjct: 299 KEDDGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSPGKDVR 358

Query: 343 NSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEV 402
           NSDMHLLD+ESMGKS DG++YVITG WNP +P F  +NEETPKDK ++MT AVD+V+TEV
Sbjct: 359 NSDMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEV 418

Query: 403 VEPVRFLLETVVRVYPANER-FWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQ 461
            EPVRFLLET VRV   NER FW FS+++ TE FF++LKQ + +   N  D +YEVV L+
Sbjct: 419 QEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIKQRERKNNTDTLYEVVCLE 478

Query: 462 RESDKEEPVT--------PTSGGG----PMSPQDDEAEEESDNELSSGTGDVSKDCPEKI 509
            ES++E   T        P SG      P  P+DDE EE++D  L SG+GDVSK+C EKI
Sbjct: 479 SESERERRKTTASPSVRLPQSGSQSSVIPSPPEDDE-EEDNDEPLLSGSGDVSKECAEKI 537

Query: 510 LYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILIT 569
           L +WGELL KWH NL  RPK LS+LV++GVPEALR EVWQLLAGCH+N  ++++YRILIT
Sbjct: 538 LETWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDHLVEKYRILIT 597

Query: 570 KDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAV 629
           K+S Q+S ITRDI+RTFPAHDYFKDTGGDGQ+SLYKICKAYSVYDE+IGYCQGQSFLAAV
Sbjct: 598 KESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAV 657

Query: 630 LLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLN 689
           LLLHMPEEQAF VLVKIM+DYGLR+L++ NFEDLHCKFYQLERLMQE +PDL++HF D++
Sbjct: 658 LLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDIS 717

Query: 690 LEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFE 749
           LEAHMYASQWFLTLFTAKFPL MVFHIIDLLLCEG+++IF+VAL LLKTSK+DLL  DFE
Sbjct: 718 LEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTDFE 777

Query: 750 GALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDR 809
           GALKFFRVQLPKRYR+EENA++LME ACN+K+  KKLKKYEKEY TMRE Q QQEDP++R
Sbjct: 778 GALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIER 837

Query: 810 YK 811
           ++
Sbjct: 838 FE 839


>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
          Length = 810

 Score =  246 bits (628), Expect = 6e-65
 Identities = 119/299 (39%), Positives = 185/299 (61%), Gaps = 3/299 (1%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDS 572
           WG ++ +W      + K +  LV  G+P   RA VWQLL     +  + D+Y  L+   S
Sbjct: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ-SMPIKDQYSELLKMTS 196

Query: 573 AQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLL 632
             E +I RDI RT+P H++FK+    GQE L+ + KAYS+ D ++GYCQG +F+  +LL+
Sbjct: 197 PCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLM 256

Query: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEA 692
            MPEE+AFCV VK+M DY LR+L++ +  +L    YQ E ++QE LP+L  HF   +   
Sbjct: 257 QMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHT 316

Query: 693 HMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752
            MYAS WFLT+F   FPL +   I D+ + EGL I+F V LALL+ ++ +L+Q D EG L
Sbjct: 317 SMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGML 376

Query: 753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYK 811
           + F+  +P ++    +  +L++ A  +K  +KK+KK EKEY T++  +++++  + R +
Sbjct: 377 QHFQKVIPHQFDGVPD--KLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLR 433



 Score = 31.2 bits (69), Expect = 4.0
 Identities = 20/44 (45%), Positives = 23/44 (52%), Gaps = 2/44 (4%)

Query: 93  ASQTNKPSLQLILDPSNTEISTP--RPSSPGGLPEEDSVLFNKL 134
           ASQ   PS  L    S+T +STP   PSSP  L  +D  L  KL
Sbjct: 46  ASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDDLELLAKL 89


>gi|229577000 ecotropic viral integration site 5-like isoform 1
           [Homo sapiens]
          Length = 805

 Score =  244 bits (623), Expect = 2e-64
 Identities = 117/299 (39%), Positives = 185/299 (61%), Gaps = 3/299 (1%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDS 572
           WG +  +W      + K L  L++ G+P   RA VWQLL    D   + ++Y  L+   S
Sbjct: 90  WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATD-MPVKNQYSELLKMSS 148

Query: 573 AQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLL 632
             E +I RDI RT+P H++FK     GQE L+ + KAYS+ D ++GYCQG +F+  +LL+
Sbjct: 149 PCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLM 208

Query: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEA 692
            MPEE+AFCV V++M +Y LR+L++ +  +L    YQ E ++QEQLPDL++HF   +   
Sbjct: 209 QMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268

Query: 693 HMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752
            MYAS WFLTLF   FPL +   + D+ + EGL I+F V LALL+ ++ +L+Q D EG  
Sbjct: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS 328

Query: 753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYK 811
           ++F+  +P ++  +    +L+ +A  +K   KK+K+ EKEY  M+  +++++  + R +
Sbjct: 329 QYFQRVIPHQF--DSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLR 385


>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
           sapiens]
          Length = 794

 Score =  244 bits (623), Expect = 2e-64
 Identities = 117/299 (39%), Positives = 185/299 (61%), Gaps = 3/299 (1%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDS 572
           WG +  +W      + K L  L++ G+P   RA VWQLL    D   + ++Y  L+   S
Sbjct: 90  WGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATD-MPVKNQYSELLKMSS 148

Query: 573 AQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLL 632
             E +I RDI RT+P H++FK     GQE L+ + KAYS+ D ++GYCQG +F+  +LL+
Sbjct: 149 PCEKLIRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLM 208

Query: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEA 692
            MPEE+AFCV V++M +Y LR+L++ +  +L    YQ E ++QEQLPDL++HF   +   
Sbjct: 209 QMPEEEAFCVFVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHT 268

Query: 693 HMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752
            MYAS WFLTLF   FPL +   + D+ + EGL I+F V LALL+ ++ +L+Q D EG  
Sbjct: 269 SMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS 328

Query: 753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYK 811
           ++F+  +P ++  +    +L+ +A  +K   KK+K+ EKEY  M+  +++++  + R +
Sbjct: 329 QYFQRVIPHQF--DSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLR 385


>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
          Length = 1298

 Score =  201 bits (511), Expect = 2e-51
 Identities = 116/335 (34%), Positives = 193/335 (57%), Gaps = 17/335 (5%)

Query: 482  QDDEAEEESDNELSSGTGDVSKD----CPEKILYSWGELLGKWHSNLGARPKGLSTLVKS 537
            ++++  E S +EL S    +  +    C +++L +W + L    + +    + + TL+K 
Sbjct: 858  KENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKE 917

Query: 538  GVPEALRAEVWQLLAGCHDNQAMLDR--------YRILITKDSAQESVITRDIHRTFPAH 589
            GVP++ R E+WQ LA  +  +  L          Y+ L+ + +AQ+  I  D+ RTFP H
Sbjct: 918  GVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTH 977

Query: 590  DYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYD 649
             YF    G GQ SL+ + KAYS+ D+++GYCQG SF+A VLLLHM EEQAF +L  +MYD
Sbjct: 978  PYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYD 1037

Query: 650  YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFP 709
             G R  YR +   L  + YQL RL+ +   DL++H  +  +   +YA+ WFLTLF ++F 
Sbjct: 1038 LGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFS 1097

Query: 710  LCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQAD-FEGALKFFRVQLPKRYRAEEN 768
            L  V  + D++  +G  +IF VAL+LL + +  +++ + FE  ++F +  LP    +E  
Sbjct: 1098 LGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSE-- 1155

Query: 769  ARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQ 803
              +++ Q   + + +K+L  YE EY  +++ +LQ+
Sbjct: 1156 MEKIITQVFEMDI-SKQLHAYEVEYHVLQD-ELQE 1188


>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
            [Homo sapiens]
          Length = 1168

 Score =  182 bits (462), Expect = 1e-45
 Identities = 123/404 (30%), Positives = 194/404 (48%), Gaps = 52/404 (12%)

Query: 455  YEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAE-----------------------EESD 491
            YE  S   E     P+ P    GP  P  +E +                       E+ +
Sbjct: 682  YEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKEN 741

Query: 492  NELSSGTGDVSKD-----------CPEKILYSWGELLGK-WHSNLGARPKGLSTLVKSGV 539
             +L +   D+              C +++   W ++L     S +    + + + V  GV
Sbjct: 742  QKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGV 801

Query: 540  PEALRAEVWQLLAGCHDNQAMLDR--------YRILITKDSAQESVITRDIHRTFPAHDY 591
            P   R E+W+ LA     +             Y+ L+ + ++Q+  I  D+ RTFP H Y
Sbjct: 802  PRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPY 861

Query: 592  FKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYG 651
            F    G GQ SLY I KAYS+ D+++GYCQG SF+A +LLLHM EE+AF +L  +M+D G
Sbjct: 862  FSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMG 921

Query: 652  LRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLC 711
            LR  YR +   L  + YQL RL+ +   DL++H  +  +   +YA+ WFLT+F ++FPL 
Sbjct: 922  LRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLG 981

Query: 712  MVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQAD-FEGALKFFRVQLPKRYRAEENAR 770
             V  + D++  +G  +IF VAL+LL + K  +LQ +  E  + F +  LP     +    
Sbjct: 982  FVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQ--ME 1039

Query: 771  RLMEQACNIKVPTKKLKKYEKEYQTMRE-----SQLQQEDPMDR 809
            + + Q   + +  K+L+ YE EY  ++E     S L     MD+
Sbjct: 1040 KTINQVFEMDI-AKQLQAYEVEYHVLQEELIDSSPLSDNQRMDK 1082


>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
          Length = 508

 Score =  155 bits (392), Expect = 1e-37
 Identities = 101/315 (32%), Positives = 150/315 (47%), Gaps = 19/315 (6%)

Query: 439 LKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNEL---- 494
           + +S G+    A  A  E +S  RES  + P   T+        D EA   ++  +    
Sbjct: 1   MAKSNGENGPRA-PAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFG 59

Query: 495 ----SSGTGDVSKDCPEKILYS----WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAE 546
               S G     ++ P ++L      W ++L  W   +  + K +    + G+P +LR  
Sbjct: 60  FIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR 119

Query: 547 VWQLLAG----CHDNQAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQES 602
            WQ L+G       N    D    +   D     VI RD+HR FP H+ F   GG GQ+ 
Sbjct: 120 AWQYLSGGKVKLQQNPGKFDELD-MSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQD 178

Query: 603 LYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFED 662
           L+++ KAY++Y  + GYCQ Q+ +AAVLL+HMP EQAF  LV+I   Y L   Y    E 
Sbjct: 179 LFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKY-LPGYYSEKLEA 237

Query: 663 LHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLC 722
           +      L  L+Q+  P  H H S   ++  +Y ++WF+  F+   P   V  + D+  C
Sbjct: 238 IQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFC 297

Query: 723 EGLNIIFHVALALLK 737
           EG+ IIF V L LLK
Sbjct: 298 EGVKIIFRVGLVLLK 312


>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
          Length = 446

 Score =  147 bits (371), Expect = 4e-35
 Identities = 93/290 (32%), Positives = 133/290 (45%), Gaps = 5/290 (1%)

Query: 451 GDAIYEVVSLQRESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKIL 510
           G+ + +   LQ +S      +  SG GP   Q D       +    G G    D   +  
Sbjct: 6   GEDLVQPPELQDDSSSLGSDSELSGPGPYR-QADRYGFIGGSSAEPGPGHPPADLIRQRE 64

Query: 511 YSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILIT 569
             W E+   W   +  R K +    + G+P ALRA  W LL G H  Q      Y+ L  
Sbjct: 65  MKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAE 124

Query: 570 K--DSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLA 627
              D      I RD+HR FP H+ F    G GQ+ L ++ KAY++Y  + GYCQ Q  +A
Sbjct: 125 APGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVA 184

Query: 628 AVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSD 687
           AVLL+H+P E+AF  LV+I   Y L   Y  + E +         L++  LP +H H   
Sbjct: 185 AVLLMHLPPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQ 243

Query: 688 LNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
           + +   +Y  +WFL LF    P   V  + D  L EG  ++F V L L++
Sbjct: 244 VGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293


>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
          Length = 808

 Score =  146 bits (369), Expect = 7e-35
 Identities = 81/229 (35%), Positives = 117/229 (51%), Gaps = 6/229 (2%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHD----NQAMLDRYRILI 568
           W ++   W   L  R + +    + G+P +LRA+ WQ L+   +    N    +      
Sbjct: 335 WLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFEELE-RA 393

Query: 569 TKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAA 628
             D     VI +D+HR FP H+ F   GG GQ+ LY+I KAY++Y  D GYCQ Q+ +AA
Sbjct: 394 PGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAA 453

Query: 629 VLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDL 688
           VLL+HMP EQAF  LV+I   Y L   Y    E +         L++   P  H H    
Sbjct: 454 VLLMHMPAEQAFWCLVQICDKY-LPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQ 512

Query: 689 NLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLK 737
            ++  +Y ++WF+ +F    P   V  + D+  CEG+ IIF VAL LL+
Sbjct: 513 RIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLR 561


>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
          Length = 828

 Score =  115 bits (287), Expect = 2e-25
 Identities = 72/243 (29%), Positives = 119/243 (48%), Gaps = 12/243 (4%)

Query: 535 VKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITK-------DSAQESVITRDIHRTFP 587
           +  G+P  LR EVW LL    +   M +  R L +K        S     I  D++RTF 
Sbjct: 97  IYKGIPLQLRGEVWALLL---EIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFR 153

Query: 588 AHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIM 647
            H  F+D  G  Q+SL+ +  AYS+Y+ ++GYCQG S + A+LL++M EE AF  LVK+ 
Sbjct: 154 DHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLF 213

Query: 648 Y--DYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFT 705
               + +   +   F  L       E+++ + L  L  H     +    Y  +WF   F 
Sbjct: 214 SGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFL 273

Query: 706 AKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRA 765
            + P  +   I D+ + EG  ++  ++  +LK  K+ L++   E  ++FF+  L K +  
Sbjct: 274 DRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFF 333

Query: 766 EEN 768
           E++
Sbjct: 334 EDD 336


>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
          Length = 845

 Score =  115 bits (287), Expect = 2e-25
 Identities = 72/243 (29%), Positives = 119/243 (48%), Gaps = 12/243 (4%)

Query: 535 VKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITK-------DSAQESVITRDIHRTFP 587
           +  G+P  LR EVW LL    +   M +  R L +K        S     I  D++RTF 
Sbjct: 114 IYKGIPLQLRGEVWALLL---EIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFR 170

Query: 588 AHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIM 647
            H  F+D  G  Q+SL+ +  AYS+Y+ ++GYCQG S + A+LL++M EE AF  LVK+ 
Sbjct: 171 DHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLF 230

Query: 648 Y--DYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFT 705
               + +   +   F  L       E+++ + L  L  H     +    Y  +WF   F 
Sbjct: 231 SGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFL 290

Query: 706 AKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRA 765
            + P  +   I D+ + EG  ++  ++  +LK  K+ L++   E  ++FF+  L K +  
Sbjct: 291 DRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELVEFFQETLAKDFFF 350

Query: 766 EEN 768
           E++
Sbjct: 351 EDD 353


>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
          Length = 1140

 Score =  112 bits (279), Expect = 2e-24
 Identities = 72/229 (31%), Positives = 119/229 (51%), Gaps = 9/229 (3%)

Query: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSAQESV-----ITRD 581
           R + +  LV  G+PE+LR  +W L +    + A    Y   + ++S  +       I RD
Sbjct: 494 RTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERD 553

Query: 582 IHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFC 641
           +HR+ P H  F++  G    +L ++  AY+  +  IGYCQ  + L +VLLL+  EE+AF 
Sbjct: 554 LHRSLPEHPAFQNETGIA--ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFW 611

Query: 642 VLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFL 701
           +LV +  +  L D + +            E L++  LP+L  H +DL+  A +  S WFL
Sbjct: 612 LLVAVC-ERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLS-WFL 669

Query: 702 TLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEG 750
           TLF +  PL    +++D    +G+  IF + LA+L+ + EDL  +  +G
Sbjct: 670 TLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDG 718


>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
           isoform b [Homo sapiens]
          Length = 1233

 Score =  111 bits (278), Expect = 2e-24
 Identities = 90/305 (29%), Positives = 142/305 (46%), Gaps = 24/305 (7%)

Query: 463 ESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWG--ELLGK- 519
           +   E+P +P S   P+S +     +E+            K+ P + L + G  E + + 
Sbjct: 424 QEGSEQPASPAS---PLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480

Query: 520 -WHSNLGARPKGLS--------TLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRI-LIT 569
            WH +     +G+          LV  G+PE+LR E+W L +G  +       Y   L+ 
Sbjct: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540

Query: 570 KDSAQESVIT----RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSF 625
           K + + S+ T    RD+HR+ P H  F++  G    +L ++  AY+  +  IGYCQ  + 
Sbjct: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNI 598

Query: 626 LAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHF 685
           + +VLLL+  EE+AF +LV +  +  L D Y              E L ++ LP L    
Sbjct: 599 VTSVLLLYGSEEEAFWLLVALC-ERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKM 657

Query: 686 SDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ 745
            DL + + +  S WFLTLF +  P      I+D    EG+ +I  VALA+L  + E LL 
Sbjct: 658 QDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLG 716

Query: 746 ADFEG 750
              EG
Sbjct: 717 CSDEG 721


>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1250

 Score =  111 bits (278), Expect = 2e-24
 Identities = 90/305 (29%), Positives = 142/305 (46%), Gaps = 24/305 (7%)

Query: 463 ESDKEEPVTPTSGGGPMSPQDDEAEEESDNELSSGTGDVSKDCPEKILYSWG--ELLGK- 519
           +   E+P +P S   P+S +     +E+            K+ P + L + G  E + + 
Sbjct: 424 QEGSEQPASPAS---PLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE 480

Query: 520 -WHSNLGARPKGLS--------TLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRI-LIT 569
            WH +     +G+          LV  G+PE+LR E+W L +G  +       Y   L+ 
Sbjct: 481 SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE 540

Query: 570 KDSAQESVIT----RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSF 625
           K + + S+ T    RD+HR+ P H  F++  G    +L ++  AY+  +  IGYCQ  + 
Sbjct: 541 KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIA--ALRRVLTAYAFRNPTIGYCQAMNI 598

Query: 626 LAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHF 685
           + +VLLL+  EE+AF +LV +  +  L D Y              E L ++ LP L    
Sbjct: 599 VTSVLLLYGSEEEAFWLLVALC-ERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKM 657

Query: 686 SDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ 745
            DL + + +  S WFLTLF +  P      I+D    EG+ +I  VALA+L  + E LL 
Sbjct: 658 QDLGVISSISLS-WFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLG 716

Query: 746 ADFEG 750
              EG
Sbjct: 717 CSDEG 721


>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
          Length = 963

 Score =  111 bits (277), Expect = 3e-24
 Identities = 74/238 (31%), Positives = 113/238 (47%), Gaps = 15/238 (6%)

Query: 531 LSTLVKSGVPEALRAEVWQLLAGCH-----DN------QAMLDRYRILITKDSAQESVIT 579
           L  L+++G+P   R++VW+     H     DN      Q +L +    + K +     I 
Sbjct: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQK---ALEKQNPASKQIE 711

Query: 580 RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQA 639
            D+ RT P + ++     +G + L  +  A+S  + DIGYCQG + L AV LL++ +E A
Sbjct: 712 LDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDA 771

Query: 640 FCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQW 699
           F  LV I+  +  RD Y                LM E+LP LH HF    ++  +    W
Sbjct: 772 FWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNW 831

Query: 700 FLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ-ADFEGALKFFR 756
           FL +F       ++F I D  L EG  +IF  ALAL K  +E++L+  D     K+ R
Sbjct: 832 FLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889


>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
          Length = 914

 Score =  111 bits (277), Expect = 3e-24
 Identities = 74/238 (31%), Positives = 113/238 (47%), Gaps = 15/238 (6%)

Query: 531 LSTLVKSGVPEALRAEVWQLLAGCH-----DN------QAMLDRYRILITKDSAQESVIT 579
           L  L+++G+P   R++VW+     H     DN      Q +L +    + K +     I 
Sbjct: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQK---ALEKQNPASKQIE 711

Query: 580 RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQA 639
            D+ RT P + ++     +G + L  +  A+S  + DIGYCQG + L AV LL++ +E A
Sbjct: 712 LDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDA 771

Query: 640 FCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQW 699
           F  LV I+  +  RD Y                LM E+LP LH HF    ++  +    W
Sbjct: 772 FWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNW 831

Query: 700 FLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ-ADFEGALKFFR 756
           FL +F       ++F I D  L EG  +IF  ALAL K  +E++L+  D     K+ R
Sbjct: 832 FLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889


>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
           sapiens]
          Length = 1266

 Score =  110 bits (275), Expect = 5e-24
 Identities = 71/222 (31%), Positives = 117/222 (52%), Gaps = 9/222 (4%)

Query: 534 LVKSGVPEALRAEVWQLLAGCHDNQAMLDRY-RILITKDSAQESVIT----RDIHRTFPA 588
           LV  G+PE++R E+W LL+G  + +A    Y   L+ K   + ++ T    RD+HR+ P 
Sbjct: 511 LVLKGIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPE 570

Query: 589 HDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMY 648
           H  F++  G    +L ++  AY+  + +IGYCQ  + + +VLLL+  EE+AF +LV +  
Sbjct: 571 HPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALC- 627

Query: 649 DYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKF 708
           +  L D Y              E L ++ +P L+    DL + + +  S WFLTLF +  
Sbjct: 628 ERMLPDYYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLS-WFLTLFLSVM 686

Query: 709 PLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEG 750
           P      ++D    EG+ +IF +ALA+L  + + LL    +G
Sbjct: 687 PFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDG 728


>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
          Length = 749

 Score =  108 bits (269), Expect = 3e-23
 Identities = 71/270 (26%), Positives = 128/270 (47%), Gaps = 9/270 (3%)

Query: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILITKDSAQESV----ITRD 581
           R + L +LV +G+P  +R ++W  L+G    +   +  YR ++   S  E++    I +D
Sbjct: 103 RSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKD 162

Query: 582 IHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFC 641
           + RT P++  F   G  G   L ++ +A +    +IGYCQG   +AA LLL + EE AF 
Sbjct: 163 LLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFW 222

Query: 642 VLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFL 701
           ++  I+ D      +      +      L  L+ + LP L     + ++E  +    WFL
Sbjct: 223 MMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFL 282

Query: 702 TLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPK 761
           T F +   + ++  I DL   EG  ++F + L +L   +E+L+Q++   ++      +P 
Sbjct: 283 TAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPS 342

Query: 762 RYRAEE----NARRLMEQACNIKVPTKKLK 787
           +    E     A RL     ++ V T++ K
Sbjct: 343 QMEDAELLLGVAMRLAGSLTDVAVETQRRK 372


>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
          Length = 413

 Score =  106 bits (265), Expect = 8e-23
 Identities = 82/278 (29%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 515 ELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN----------QAMLDRY 564
           E+L  W +   +R   +  L   G+P ++R +VW L  G   N              +R+
Sbjct: 100 EILPNWETMWCSRK--VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERW 157

Query: 565 RILITKDSAQES---------------VITRDIHRTFPAHDYFKDTGGDGQESLYKICKA 609
           R L T  S  E+               +I  DI RTFP    F+  GG   + L+ I  A
Sbjct: 158 RSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ-GGPYHDMLHSILGA 216

Query: 610 YSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQ 669
           Y+ Y  D+GY QG SF+AAVL+L++    AF     ++        +R +   +   F  
Sbjct: 217 YTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAA 276

Query: 670 LERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIF 729
            E   +E LP L +HF   NL   +Y   W  TL++   PL +   I D+   +G   +F
Sbjct: 277 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 336

Query: 730 HVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEE 767
             AL +LK  ++ L + DF    +F   +LP+   AEE
Sbjct: 337 RTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAEE 373


>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score =  106 bits (265), Expect = 8e-23
 Identities = 82/278 (29%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 515 ELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN----------QAMLDRY 564
           E+L  W +   +R   +  L   G+P ++R +VW L  G   N              +R+
Sbjct: 380 EILPNWETMWCSRK--VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERW 437

Query: 565 RILITKDSAQES---------------VITRDIHRTFPAHDYFKDTGGDGQESLYKICKA 609
           R L T  S  E+               +I  DI RTFP    F+  GG   + L+ I  A
Sbjct: 438 RSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ-GGPYHDMLHSILGA 496

Query: 610 YSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQ 669
           Y+ Y  D+GY QG SF+AAVL+L++    AF     ++        +R +   +   F  
Sbjct: 497 YTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAA 556

Query: 670 LERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIF 729
            E   +E LP L +HF   NL   +Y   W  TL++   PL +   I D+   +G   +F
Sbjct: 557 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 616

Query: 730 HVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEE 767
             AL +LK  ++ L + DF    +F   +LP+   AEE
Sbjct: 617 RTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAEE 653


>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
          Length = 693

 Score =  106 bits (265), Expect = 8e-23
 Identities = 82/278 (29%), Positives = 124/278 (44%), Gaps = 29/278 (10%)

Query: 515 ELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN----------QAMLDRY 564
           E+L  W +   +R   +  L   G+P ++R +VW L  G   N              +R+
Sbjct: 380 EILPNWETMWCSRK--VRDLWWQGIPPSVRGKVWSLAIGNELNITHELFDICLARAKERW 437

Query: 565 RILITKDSAQES---------------VITRDIHRTFPAHDYFKDTGGDGQESLYKICKA 609
           R L T  S  E+               +I  DI RTFP    F+  GG   + L+ I  A
Sbjct: 438 RSLSTGGSEVENEDAGFSAADREASLELIKLDISRTFPNLCIFQQ-GGPYHDMLHSILGA 496

Query: 610 YSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQ 669
           Y+ Y  D+GY QG SF+AAVL+L++    AF     ++        +R +   +   F  
Sbjct: 497 YTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAA 556

Query: 670 LERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIF 729
            E   +E LP L +HF   NL   +Y   W  TL++   PL +   I D+   +G   +F
Sbjct: 557 FEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLF 616

Query: 730 HVALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEE 767
             AL +LK  ++ L + DF    +F   +LP+   AEE
Sbjct: 617 RTALGILKLFEDILTKMDFIHMAQFL-TRLPEDLPAEE 653


>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
           isoform a [Homo sapiens]
          Length = 1120

 Score =  106 bits (264), Expect = 1e-22
 Identities = 68/223 (30%), Positives = 109/223 (48%), Gaps = 9/223 (4%)

Query: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSA-----QESVITRD 581
           R K    LV  G+PE LR E+W L +G  ++ A    Y   + + S          I RD
Sbjct: 476 RTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERD 535

Query: 582 IHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFC 641
           + R+ P H  F+     G  +L ++  AY+  +  IGYCQ  + L +VLLL+  EE+AF 
Sbjct: 536 LRRSLPEHPAFQSD--TGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFW 593

Query: 642 VLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFL 701
           +LV +  +  L D +              E L+++ LP L  H +D+   + +  S WFL
Sbjct: 594 LLVAVC-ERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLS-WFL 651

Query: 702 TLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLL 744
           TLF +  P+    +++D    +G+  I  + LA+L  + + LL
Sbjct: 652 TLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLL 694


>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
          Length = 336

 Score =  101 bits (251), Expect = 3e-21
 Identities = 73/227 (32%), Positives = 113/227 (49%), Gaps = 10/227 (4%)

Query: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDR----YRILIT--KDSAQESVITR 580
           R + +   V+ GVP   RA VW +L+G    QA +D+    Y  L+   ++   E  I  
Sbjct: 57  RSRTVKRYVRKGVPLEHRARVWMVLSGA---QAQMDQNPGYYHQLLQGERNPRLEDAIRT 113

Query: 581 DIHRTFPAHDYFKDTGGDG-QESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQA 639
           D++RTFP +  F+ T     Q +LY +  AY  +++ +GYCQG +F+A  L+L    E+ 
Sbjct: 114 DLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEE 173

Query: 640 FCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQW 699
              L+  +    L D Y      L      L  L++ +LP + +    L +   +  S+W
Sbjct: 174 SFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRW 233

Query: 700 FLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQA 746
           F+ LF    P+  V  I D L  EG  IIF VAL L+K  +E +L+A
Sbjct: 234 FICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEA 280


>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
          Length = 775

 Score =  100 bits (250), Expect = 4e-21
 Identities = 75/276 (27%), Positives = 119/276 (43%), Gaps = 27/276 (9%)

Query: 515 ELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN------QAMLDRYR--- 565
           E+L  W      R   +  L   G+P ++R +VW L  G   N      +  L R +   
Sbjct: 463 EILPNWEVMRSTRR--VRELWWQGLPPSVRGKVWSLAVGNELNITPELYEIFLSRAKERW 520

Query: 566 --------------ILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYS 611
                         + +    A   +I  DI RTFP+  Y    GG   + L+ I  AY+
Sbjct: 521 KSFSETSSENDTEGVSVADREASLELIKLDISRTFPSL-YIFQKGGPYHDVLHSILGAYT 579

Query: 612 VYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLE 671
            Y  D+GY QG SF+AAVL+L++ E  AF     ++        +R +   +   F   E
Sbjct: 580 CYRPDVGYVQGMSFIAAVLILNLEEADAFIAFANLLNKPCQLAFFRVDHSMMLKYFATFE 639

Query: 672 RLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHV 731
              +E L  L  HF   +L   +Y   W  TL++   PL +   + D+   +G   +F  
Sbjct: 640 VFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLDLACRVWDVFCRDGEEFLFRT 699

Query: 732 ALALLKTSKEDLLQADFEGALKFFRVQLPKRYRAEE 767
            L +L+  ++ LLQ DF    +F   +LP+   +E+
Sbjct: 700 GLGILRLYEDILLQMDFIHIAQFL-TKLPEDITSEK 734


>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
          Length = 917

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 77/293 (26%), Positives = 137/293 (46%), Gaps = 25/293 (8%)

Query: 531 LSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDR-YRILITKDSAQESVITR----DIHRT 585
           L  L+++GVP   R  VW+ L             Y+ L+++  A+E    R    D++RT
Sbjct: 618 LKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRT 677

Query: 586 FPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQ-AFCVLV 644
           FP + +F        + L ++  A+S  +  IGYCQG + LAA+ LL + EE+ AF  LV
Sbjct: 678 FPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLV 737

Query: 645 KIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFLTLF 704
            I+      D Y N           L+ L+ E+LP L +H    +++  +    WFL +F
Sbjct: 738 AIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVF 797

Query: 705 TAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGALKFFRVQLPKRYR 764
                  ++  + D  L EG            K +++++L+   +  L+ ++  L    +
Sbjct: 798 ADSLISNILLRVWDAFLYEG-----------TKYNEKEILR--LQNGLEIYQ-YLRFFTK 843

Query: 765 AEENARRLMEQACNIKVP--TKKLKKYEKEYQTMRESQLQQEDPMDRYKFVYL 815
              N+R+LM  A N   P   K+L++    ++   E++L++   +++ K  YL
Sbjct: 844 TISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRE---LEQLKAEYL 893


>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
          Length = 1406

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 61/240 (25%), Positives = 105/240 (43%), Gaps = 10/240 (4%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDS 572
           W E+LG+W +        L   V  G+P  +R  VW +L    + + + +  R  I K+ 
Sbjct: 77  WMEMLGEWETY--KHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIK-LKNPGRYQIMKER 133

Query: 573 AQESV-----ITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLA 627
            + S      I  D+  T   H +F+D  G  Q  L+ I  AYS Y+ ++GYC+  S + 
Sbjct: 134 GKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHIT 193

Query: 628 AVLLLHMPEEQAFCVLVKIMYD--YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHF 685
           A+ LL++PEE AF  LV+++    + L   +  N   +     Q E ++ +  P    H 
Sbjct: 194 ALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQ 253

Query: 686 SDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ 745
               L     +    L        L +   + D+ L EG  ++  +    LK  ++ L++
Sbjct: 254 DKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMK 313


>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
          Length = 549

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 60/237 (25%), Positives = 100/237 (42%), Gaps = 8/237 (3%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILITK- 570
           W ++LG W     +R   L      G+P  +R  +W +L    + +     RY+I+  K 
Sbjct: 78  WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135

Query: 571 --DSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAA 628
              S     I RDI  T   H +F+D  G  Q  L  I  AY  Y+ ++GYC+  S +AA
Sbjct: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195

Query: 629 VLLLHMPEEQAFCVLVKIMYD--YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFS 686
           + LL++PEE AF  LV+++    + L+  +  N   +     Q E ++    P    H  
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255

Query: 687 DLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDL 743
             +L          + +      L +   + D+ L EG   +  +     K  ++ L
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312


>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
          Length = 549

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 60/237 (25%), Positives = 100/237 (42%), Gaps = 8/237 (3%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILITK- 570
           W ++LG W     +R   L      G+P  +R  +W +L    + +     RY+I+  K 
Sbjct: 78  WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135

Query: 571 --DSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAA 628
              S     I RDI  T   H +F+D  G  Q  L  I  AY  Y+ ++GYC+  S +AA
Sbjct: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195

Query: 629 VLLLHMPEEQAFCVLVKIMYD--YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFS 686
           + LL++PEE AF  LV+++    + L+  +  N   +     Q E ++    P    H  
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255

Query: 687 DLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDL 743
             +L          + +      L +   + D+ L EG   +  +     K  ++ L
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312


>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
          Length = 549

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 59/237 (24%), Positives = 100/237 (42%), Gaps = 8/237 (3%)

Query: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLD-RYRILITK- 570
           W ++LG W     +R   L      G+P  +R  +W +L    + +     RY+I+  K 
Sbjct: 78  WVDMLGDWEKYKSSRK--LIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKG 135

Query: 571 --DSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAA 628
              S     I RD+  T   H +F+D  G  Q  L  I  AY  Y+ ++GYC+  S +AA
Sbjct: 136 KKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195

Query: 629 VLLLHMPEEQAFCVLVKIMYD--YGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFS 686
           + LL++PEE AF  LV+++    + L+  +  N   +     Q E ++    P    H  
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255

Query: 687 DLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDL 743
             +L          + +      L +   + D+ L EG   +  +     K  ++ L
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 312


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,387,681
Number of Sequences: 37866
Number of extensions: 1508224
Number of successful extensions: 5806
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 5619
Number of HSP's gapped (non-prelim): 155
length of query: 815
length of database: 18,247,518
effective HSP length: 111
effective length of query: 704
effective length of database: 14,044,392
effective search space: 9887251968
effective search space used: 9887251968
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.