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Search of human proteins with 78000169
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
(781 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 1558 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 1487 0.0
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 1457 0.0
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 1311 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 1124 0.0
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 1025 0.0
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 781 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 407 e-113
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 406 e-113
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 406 e-113
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 404 e-112
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 385 e-106
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 384 e-106
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 291 1e-78
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 291 1e-78
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 278 1e-74
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 271 1e-72
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 106 9e-23
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 106 9e-23
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 106 9e-23
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 95 3e-19
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 92 1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 84 7e-16
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 82 2e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 81 4e-15
gi|39930351 dynamin binding protein [Homo sapiens] 80 6e-15
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 79 1e-14
gi|11321634 CD2-associated protein [Homo sapiens] 79 2e-14
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 79 2e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 79 2e-14
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 1558 bits (4033), Expect = 0.0
Identities = 781/781 (100%), Positives = 781/781 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 180
Query: 181 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 240
TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
Sbjct: 181 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 240
Query: 241 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 300
RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
Sbjct: 241 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 300
Query: 301 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 360
TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
Sbjct: 301 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 360
Query: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 420
AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
Sbjct: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 420
Query: 421 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 480
SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
Sbjct: 421 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 480
Query: 481 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 540
HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
Sbjct: 481 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 540
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
Sbjct: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
Query: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
Sbjct: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
Query: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
Sbjct: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
Query: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 780
DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
Sbjct: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 780
Query: 781 L 781
L
Sbjct: 781 L 781
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 1487 bits (3850), Expect = 0.0
Identities = 778/905 (85%), Positives = 778/905 (85%), Gaps = 124/905 (13%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNL--------------------------------------- 141
NGNAQPSSLAAKGYRSVHPNL
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVP 180
Query: 142 --PSD-------------KSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 186
P D S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP
Sbjct: 181 PAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNP 240
Query: 187 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 246
TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS
Sbjct: 241 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 300
Query: 247 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 306
TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS
Sbjct: 301 TQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLS 360
Query: 307 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 366
VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI
Sbjct: 361 VPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSI 420
Query: 367 YEYQPGKSSVLTNEKMS------------------------------------------- 383
YEYQPGKSSVLTNEKMS
Sbjct: 421 YEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSIL 480
Query: 384 -------SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 436
SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG
Sbjct: 481 PREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGG 540
Query: 437 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 496
DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR
Sbjct: 541 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKR 600
Query: 497 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 556
EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL
Sbjct: 601 EQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTL 660
Query: 557 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 616
KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY
Sbjct: 661 KELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEY 720
Query: 617 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 676
GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP
Sbjct: 721 GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 780
Query: 677 LVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQQRRVTPDRS 716
LVKNPVDYMDLPFSSSPSRSATASPQ QPQAQQRRVTPDRS
Sbjct: 781 LVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRS 840
Query: 717 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 776
QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV
Sbjct: 841 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 900
Query: 777 KPLYL 781
KPLYL
Sbjct: 901 KPLYL 905
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 1457 bits (3773), Expect = 0.0
Identities = 740/781 (94%), Positives = 740/781 (94%), Gaps = 41/781 (5%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 139
Query: 181 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 240
TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
Sbjct: 140 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 199
Query: 241 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 300
RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
Sbjct: 200 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 259
Query: 301 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 360
TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
Sbjct: 260 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 319
Query: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 420
AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
Sbjct: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 379
Query: 421 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 480
SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR
Sbjct: 380 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 439
Query: 481 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 540
HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS
Sbjct: 440 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 499
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
Sbjct: 500 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 559
Query: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
Sbjct: 560 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 619
Query: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
Sbjct: 620 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 679
Query: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 780
DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
Sbjct: 680 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 739
Query: 781 L 781
L
Sbjct: 740 L 740
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 1311 bits (3393), Expect = 0.0
Identities = 683/781 (87%), Positives = 683/781 (87%), Gaps = 97/781 (12%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPS 139
Query: 181 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 240
TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS
Sbjct: 140 TTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDS 199
Query: 241 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 300
RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED
Sbjct: 200 RRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSED 259
Query: 301 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 360
TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR
Sbjct: 260 TKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYR 319
Query: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 420
AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT
Sbjct: 320 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 379
Query: 421 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 480
SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 380 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR-- 437
Query: 481 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 540
RRH DD
Sbjct: 438 -------------------------RRH----------------------DD-------K 443
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA
Sbjct: 444 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 503
Query: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS
Sbjct: 504 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 563
Query: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ
Sbjct: 564 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 623
Query: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 780
DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY
Sbjct: 624 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 683
Query: 781 L 781
L
Sbjct: 684 L 684
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 1124 bits (2908), Expect = 0.0
Identities = 611/798 (76%), Positives = 629/798 (78%), Gaps = 80/798 (10%)
Query: 1 MSSECDGGSKAVMNGLA-----------PGSNGQDKATADPLRARSISAVKIIPVKTVKN 49
+SS D A + LA P QD AT+ + V + V T +
Sbjct: 82 LSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD-ATSSSAAQPEVIVVPLYLVNTDRG 140
Query: 50 ASGLVLP-TDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSS 108
G P T + P G V +++ +P + P H + +P+
Sbjct: 141 QEGTARPPTPLGPL------GCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPAR 194
Query: 109 ADEWRLSSSADANGNAQPSSL---AAKGYRSV-HPNLPSD-KSQDSSPLLNEVSSSLIGT 163
A S + P L A + R V P+L S DSSPLLNEVSSSLIGT
Sbjct: 195 ASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGT 254
Query: 164 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 223
DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE
Sbjct: 255 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 314
Query: 224 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 283
KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN
Sbjct: 315 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 374
Query: 284 RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE 343
RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE
Sbjct: 375 RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE 434
Query: 344 RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS 403
RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS
Sbjct: 435 RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS 494
Query: 404 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 463
NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH
Sbjct: 495 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 554
Query: 464 FIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNER 523
FIPADYLESTEEFIR RRH
Sbjct: 555 FIPADYLESTEEFIR---------------------------RRH--------------- 572
Query: 524 FGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH 583
DD EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH
Sbjct: 573 -------DD-------KEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH 618
Query: 584 GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 643
GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL
Sbjct: 619 GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 678
Query: 644 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ 703
LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ
Sbjct: 679 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ 738
Query: 704 PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR 763
PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR
Sbjct: 739 PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR 798
Query: 764 RTKQFGTFPGNYVKPLYL 781
RTKQFGTFPGNYVKPLYL
Sbjct: 799 RTKQFGTFPGNYVKPLYL 816
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 1025 bits (2649), Expect = 0.0
Identities = 584/860 (67%), Positives = 608/860 (70%), Gaps = 155/860 (18%)
Query: 1 MSSECDGGSKAVMNGLA-----------PGSNGQDKATADPLRARSISAVKIIPVKTVKN 49
+SS D A + LA P QD AT+ + V + V T +
Sbjct: 114 LSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD-ATSSSAAQPEVIVVPLYLVNTDRG 172
Query: 50 ASGLVLP-TDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSS 108
G P T + P G V +++ +P + P H + +P+
Sbjct: 173 QEGTARPPTPLGPL------GCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPAR 226
Query: 109 ADEWRLSSSADANGNAQPSSL---AAKGYRSV-HPNLPSD-KSQDSSPLLNEVSSSLIGT 163
A S + P L A + R V P+L S DSSPLLNEVSSSLIGT
Sbjct: 227 ASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGT 286
Query: 164 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 223
DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE
Sbjct: 287 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 346
Query: 224 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 283
KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN
Sbjct: 347 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 406
Query: 284 RD----------------------------------------------DDSDLYSPRYSF 297
RD DDSDLYSPRYSF
Sbjct: 407 RDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSF 466
Query: 298 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 357
SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR
Sbjct: 467 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 526
Query: 358 KYRAEP-------------------------------------------------KSIYE 368
KYRAEP K I++
Sbjct: 527 KYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWD 586
Query: 369 YQPGKSSVL------TN----------------EKM-------------SSAISPTPEIS 393
Y PG S+L TN EKM SSAISPTPEIS
Sbjct: 587 YTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEIS 646
Query: 394 SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 453
SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA
Sbjct: 647 SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 706
Query: 454 STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP 513
STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP
Sbjct: 707 STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP 766
Query: 514 THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 573
THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI
Sbjct: 767 THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 826
Query: 574 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 633
DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM
Sbjct: 827 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 886
Query: 634 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 693
SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP
Sbjct: 887 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 946
Query: 694 SRSATASPQQPQAQQRRVTP 713
SRSATASPQ + + +TP
Sbjct: 947 SRSATASPQF-SSHSKLITP 965
Score = 297 bits (760), Expect = 3e-80
Identities = 158/194 (81%), Positives = 165/194 (85%), Gaps = 8/194 (4%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 174
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 175 SSAYPSTTIVNPTI 188
+ P + PTI
Sbjct: 181 TPLGPLGCV--PTI 192
Score = 170 bits (430), Expect = 5e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 702 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 761
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
Query: 762 SRRTKQFGTFPGNYVKPLYL 781
SRRTKQFGTFPGNYVKPLYL
Sbjct: 1273 SRRTKQFGTFPGNYVKPLYL 1292
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 715 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 774
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
Query: 775 YVKPL 779
Y++ L
Sbjct: 846 YIELL 850
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 535 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 592
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
Query: 593 YIELL 597
Y++ L
Sbjct: 1286 YVKPL 1290
Score = 32.0 bits (71), Expect = 2.3
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 602 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 658
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
Query: 659 TSRQGIFPITYV 670
T + G FP YV
Sbjct: 1276 TKQFGTFPGNYV 1287
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 781 bits (2017), Expect = 0.0
Identities = 476/816 (58%), Positives = 522/816 (63%), Gaps = 145/816 (17%)
Query: 22 GQDKATADPLRARSISAVKIIPVKTVKNASGLVLPT--DMDPTKI-----------CTGK 68
GQ+ P + V IP T AS L PT D P + +G
Sbjct: 172 GQEGTARPPTPLGPLGCVPTIPA-TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGS 230
Query: 69 GAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRL-----SSSADANGN 123
A + S+ P P +P++ R+ S+P L SS D L SS +
Sbjct: 231 FAPISQTPPSFSPPPPLVPPAPEDLRR-VSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQ 289
Query: 124 AQPS-SLAAKGYRS---VHPNLP-----SDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKP 174
A PS S + Y S V+P + ++ + S L + VS +G A P+ KP
Sbjct: 290 AFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSA-PTQEKP 348
Query: 175 SSAYP---------STTIVNPTIVL--------------LQHNREQQKRLSSLSDPVSER 211
+S S +V T L + +++ K + ++
Sbjct: 349 TSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD 408
Query: 212 RVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQ-DLSDVSMDEVGIPLRNTERSKD 270
E PT + P P I++ +++ V S + + S + + L ++
Sbjct: 409 TPEENPYFPTYKFPELP--EIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPP- 465
Query: 271 WYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP 330
T Q+ DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP
Sbjct: 466 ---TSASQVAG-TADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLP 521
Query: 331 LPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP--------------------------- 363
LPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP
Sbjct: 522 LPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEE 581
Query: 364 ----------------------KSIYEYQPGKSSVL------TN---------------- 379
K I++Y PG S+L TN
Sbjct: 582 IDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADL 641
Query: 380 EKM-------------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENER 426
EKM SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENER
Sbjct: 642 EKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENER 701
Query: 427 QIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEK 486
QIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEK
Sbjct: 702 QIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEK 761
Query: 487 LLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPAR 546
LLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPAR
Sbjct: 762 LLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPAR 821
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 606
AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK
Sbjct: 822 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 881
Query: 607 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 666
KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP
Sbjct: 882 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 941
Query: 667 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ 702
ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ
Sbjct: 942 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ 977
Score = 323 bits (828), Expect = 4e-88
Identities = 293/890 (32%), Positives = 402/890 (45%), Gaps = 172/890 (19%)
Query: 1 MSSECDGGSKAVMNGLA-----------PGSNGQDKATADPLRARSISAVKIIPVKTVKN 49
+SS D A + LA P QD AT+ + V + V T +
Sbjct: 114 LSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD-ATSSSAAQPEVIVVPLYLVNTDRG 172
Query: 50 ASGLVLP-TDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSS 108
G P T + P G V +++ +P + P H + +P+
Sbjct: 173 QEGTARPPTPLGPL------GCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPAR 226
Query: 109 ADEWRLSSSADANGNAQPSSL---AAKGYRSV-HPNLPSD-KSQDSSPLLNEVSSSLIGT 163
A S + P L A + R V P+L S DSSPLLNEVSSSLIGT
Sbjct: 227 ASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGT 286
Query: 164 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 223
DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE
Sbjct: 287 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 346
Query: 224 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 283
KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN
Sbjct: 347 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 406
Query: 284 RD-DDSDLYSPRYSF---------SEDTKS-PLSVPRSKSEMSYIDGEKVVKRSATLPLP 332
RD + + Y P Y F SE+TKS + PR + + I + ++ P
Sbjct: 407 RDTPEENPYFPTYKFPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPT 466
Query: 333 ARSSSLKSSSERNDWEPP--DKKVDTRKYRAEPKSIYEYQ----------------PGKS 374
+ S ++ + +D P DT+ + P+S E P +S
Sbjct: 467 SASQVAGTADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARS 526
Query: 375 S---------------------------------------VLTNEKMSSAISPTPEISSE 395
S VLTNEKMS ISP
Sbjct: 527 SSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKN 586
Query: 396 TPGYIYSSNFH----AVKRESDGAPGDL---------TSLENERQIYKSVLEGGDIPLQG 442
P Y + S K+ D PGD T+L+ + + ++ LE ++
Sbjct: 587 EPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMET 646
Query: 443 LSGLKRPSSSASTKDSESPRHFI----PADYLESTEEFIRRRHD----DKEKLLADQRRL 494
L+ K PS++ + SP I P S ++R D D L +++
Sbjct: 647 LN--KAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIY 704
Query: 495 KREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQ 554
K E DI + +G+ T + ++ + ++ + +F +
Sbjct: 705 KSVLEGGDIPLQGLSGLKRPSSSASTKD--------SESPRHFIPADYLESTEEFIRRRH 756
Query: 555 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP--------RTYIELLPPAEKAQPK 606
KE L D + ++ ++ H G+ P + +LL + A+ K
Sbjct: 757 DDKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFITNERFGDLLNIDDTAKRK 812
Query: 607 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 666
+ E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP
Sbjct: 813 SGS-----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFP 865
Query: 667 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQ 726
TY++++ P +AQ +++TP + +
Sbjct: 866 RTYIELL---------------------------PPAEKAQPKKLTPVQVLEYGEAI--- 895
Query: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 776
A +++ E+ R G+ + ++ + D+ W+ G T + G FP YV
Sbjct: 896 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 945
Score = 297 bits (760), Expect = 3e-80
Identities = 158/194 (81%), Positives = 165/194 (85%), Gaps = 8/194 (4%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 174
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 175 SSAYPSTTIVNPTI 188
+ P + PTI
Sbjct: 181 TPLGPLGCV--PTI 192
Score = 196 bits (498), Expect = 7e-50
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 598
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Query: 599 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 641
P + + P + + E ++ + G +I
Sbjct: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
Query: 642 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 690
T R D N E PG FP + + +R
Sbjct: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
Query: 691 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 750
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
Query: 751 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 781
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 715 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 774
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
Query: 775 YVKPL 779
Y++ L
Sbjct: 868 YIELL 872
Score = 32.7 bits (73), Expect = 1.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 535 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 592
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
Query: 593 YIELL 597
Y++ L
Sbjct: 1145 YVKPL 1149
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 407 bits (1045), Expect = e-113
Identities = 270/705 (38%), Positives = 374/705 (53%), Gaps = 89/705 (12%)
Query: 122 GNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPST 181
G S +AKG+RSV PNL +S S + +S + + PS AY
Sbjct: 4 GRDSQSPDSAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSPS-AYSLP 62
Query: 182 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSR 241
+N +IV+ Q S S + D + P EKR
Sbjct: 63 ASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT---- 111
Query: 242 RVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSF 297
V+K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y++
Sbjct: 112 -VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTY 170
Query: 298 SEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL--------- 338
+ +P S P +K++ S+ D + A+ P+P
Sbjct: 171 NAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRD 230
Query: 339 KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPG 398
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + I+P P
Sbjct: 231 RSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEPW 290
Query: 399 YIYSSNFH----AVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSAS 454
Y + S K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 291 YKFFSELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSAS 341
Query: 455 TKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA----- 505
+F +RR + + L DQ + D+
Sbjct: 342 M-----------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTL 384
Query: 506 -RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQT 555
+ T P+ + L ++ +A R+ E PA+A +DFKAQT
Sbjct: 385 TKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQT 444
Query: 556 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVL 614
KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q
Sbjct: 445 SKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPG 504
Query: 615 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 674
E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K
Sbjct: 505 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 564
Query: 675 RPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQ 734
+ K DY D P S S S + Q+ T + Q + F QALY+Y P+
Sbjct: 565 KN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPR 621
Query: 735 NDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 622 NEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 406 bits (1044), Expect = e-113
Identities = 277/720 (38%), Positives = 380/720 (52%), Gaps = 114/720 (15%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIG 162
P SA WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
Query: 163 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 222
+ + PS AY +N +IV+ Q S S + D +
Sbjct: 68 SPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSS 119
Query: 223 EKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQI 279
P EKR V+K+ +DE GIP +R T +R KDWYKTMFKQI
Sbjct: 120 SIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 174
Query: 280 HKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSAT 328
H +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+
Sbjct: 175 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 234
Query: 329 LPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 379
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 235 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 294
Query: 380 EKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIP 439
E+ P P K+ D + + NE +Y+S ++
Sbjct: 295 ER------PPP------------------KKPLDYVQDHSSGVFNEASLYQSSID----- 325
Query: 440 LQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLK 495
L+RP SSAS +F +RR + + L DQ +
Sbjct: 326 ----RSLERPMSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQSASR 364
Query: 496 REQEEADIAA------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS---- 540
D+ + T P+ + L ++ +A R+
Sbjct: 365 TSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEK 424
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 425 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 484
Query: 601 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 485 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 544
Query: 660 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 719
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 545 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 603
Query: 720 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 604 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 406 bits (1043), Expect = e-113
Identities = 283/753 (37%), Positives = 391/753 (51%), Gaps = 127/753 (16%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIG 162
P SA WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
Query: 163 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 222
+ + PS AY +N +IV+ Q S S + D +
Sbjct: 85 SPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSS 136
Query: 223 EKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQI 279
P EKR V+K+ +DE GIP +R T +R KDWYKTMFKQI
Sbjct: 137 SIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
Query: 280 HKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSAT 328
H +++ DDD+D+Y+ Y+++ +P S P +K++ S+ D + A+
Sbjct: 192 HMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDAS 251
Query: 329 LPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 379
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +
Sbjct: 252 SPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQH 311
Query: 380 EK---------------------------MSSAISPTPEISSETPGYIYSSNFHAV---- 408
E+ ++ + SP P + TP SS A+
Sbjct: 312 ERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTR 367
Query: 409 --KRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIP 466
K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 368 PPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSASM----------- 407
Query: 467 ADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHH 516
+F +RR + + L DQ + D+ + T P+
Sbjct: 408 ------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSP 461
Query: 517 QFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIV 567
+ L ++ +A R+ E PA+A +DFKAQT KEL +KGD V
Sbjct: 462 SRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTV 521
Query: 568 YIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFN 626
YI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN
Sbjct: 522 YILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFN 581
Query: 627 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMD 686
DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D
Sbjct: 582 ADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPD 640
Query: 687 LPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI 746
P S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D+
Sbjct: 641 PPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDV 698
Query: 747 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 699 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 404 bits (1039), Expect = e-112
Identities = 277/691 (40%), Positives = 369/691 (53%), Gaps = 90/691 (13%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDSSPLLNEVSSSLIG 162
P SA WR + + NG+A SSLAAKG+RSV PNL +S S + +S
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 84
Query: 163 TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ 222
+ + PS AY +N +IV+ Q S S + D +
Sbjct: 85 SPMSYYQRPFSPS-AYSLPASLNSSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSS 136
Query: 223 EKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQI 279
P EKR V+K+ +DE GIP +R T +R KDWYKTMFKQI
Sbjct: 137 SIPLYRSSEEEKRVT-----VIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQI 191
Query: 280 HKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSEMSYIDGEKVVKRS-ATLPL 331
H +++ LY+P YS T PLS S S ++ D V P+
Sbjct: 192 HMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPV 248
Query: 332 PARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPE 391
P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S + +
Sbjct: 249 PPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSID 308
Query: 392 ISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP 449
S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 309 RSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTK 364
Query: 450 SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHT 509
S ++S+ S S R D+E + R ++
Sbjct: 365 SFTSSSPSSPS-------------------RAKDRE------------------SPRSYS 387
Query: 510 GVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYI 569
+ + ER G E PA+A +DFKAQT KEL +KGD VYI
Sbjct: 388 STLTDMGRSAPRERRGT-----------PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 436
Query: 570 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 628
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 437 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 496
Query: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 688
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 497 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 555
Query: 689 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 748
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 556 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 613
Query: 749 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 614 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 385 bits (988), Expect = e-106
Identities = 279/783 (35%), Positives = 401/783 (51%), Gaps = 121/783 (15%)
Query: 84 SSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPS 143
SSSP S + + P P S + + A+ + Q + L+ + S H LP
Sbjct: 76 SSSPISTPQFSKSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAPLSGQDLES-HKQLPE 134
Query: 144 DKSQDSS-PLLNEVSSSLIGTDSQAFPS-VSKPSSAYPSTTIVNPTIVLLQHNREQQKRL 201
+ + PL E S + SQ+ VS+ + S V+P + L
Sbjct: 135 LSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPMSYYQRPFSPSAYSL 194
Query: 202 -SSLSDPVSERRVGEQDSAPTQEK-------PTSPGKAIEKRAKDDSR-RVVKSTQDLSD 252
+SL+ + + DS T + TS + + ++++ R V+K+
Sbjct: 195 PASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGI 254
Query: 253 VSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP---- 304
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P
Sbjct: 255 GPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSA 314
Query: 305 LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEP 349
S P +K++ S+ D + A+ P+P +SS+E++DW+P
Sbjct: 315 QSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDP 374
Query: 350 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK---------------------------M 382
PD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +
Sbjct: 375 PDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEV 434
Query: 383 SSAISPTPEISSETPGYIYSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEGG 436
+ + SP P + TP SS A+ K+ D + + NE +Y+S ++
Sbjct: 435 TGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSID-- 488
Query: 437 DIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKE----KLLADQR 492
L+RP SSAS +F +RR + + L DQ
Sbjct: 489 -------RSLERPMSSASM-----------------ASDFRKRRKSEPAVGPPRGLGDQS 524
Query: 493 RLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS- 540
+ D+ + T P+ + L ++ +A R+
Sbjct: 525 ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGT 584
Query: 541 ---EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 597
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 585 PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKL 644
Query: 598 PPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 656
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+I
Sbjct: 645 TPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKI 704
Query: 657 PGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRS 716
PGT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T +
Sbjct: 705 PGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENI 763
Query: 717 QTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 776
Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYV
Sbjct: 764 QGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 821
Query: 777 KPL 779
K L
Sbjct: 822 KRL 824
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 384 bits (987), Expect = e-106
Identities = 231/542 (42%), Positives = 316/542 (58%), Gaps = 78/542 (14%)
Query: 261 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 314
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
Query: 315 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 360
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
Query: 361 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 418
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
Query: 419 LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR 478
L ++ S G + L G S S ++S+ S S
Sbjct: 185 PRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS------------------ 223
Query: 479 RRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKS 538
R D+E + R ++ + + ER G
Sbjct: 224 -RAKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------P 253
Query: 539 GSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP 598
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L
Sbjct: 254 EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 313
Query: 599 PAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP 657
P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IP
Sbjct: 314 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 373
Query: 658 GTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 717
GT+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 374 GTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQ 432
Query: 718 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK
Sbjct: 433 GGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVK 490
Query: 778 PL 779
L
Sbjct: 491 RL 492
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 291 bits (746), Expect = 1e-78
Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
Query: 601 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
Query: 660 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 719
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 946
Query: 720 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 947 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 113 bits (283), Expect = 6e-25
Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)
Query: 261 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 313
PL+ +R KDWYKTMFKQIH +++ LY+P YS T PLS S S
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
Query: 314 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 372
++ D V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 63 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
Query: 373 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 430
KSS+L +E+ +S + + S E P +S+F +R+S+ A G L ++
Sbjct: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
Query: 431 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 460
S G + L G S S ++S+ S S
Sbjct: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
Score = 83.2 bits (204), Expect = 9e-16
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 590 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 649
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
Query: 650 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 709
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 803 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 838
Query: 710 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 769
++ A Y++ + EL LR GD V ++++ D W+ G T + G
Sbjct: 839 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 891
Query: 770 TFPGNYVK 777
FP +YV+
Sbjct: 892 IFPVSYVE 899
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 707 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 766
++RR TP++ + +A+Y + Q EL + GD V ++ K D W+ G
Sbjct: 759 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 811
Query: 767 QFGTFPGNYVKPL 779
+ G FP +YV+ L
Sbjct: 812 RVGIFPISYVEKL 824
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 291 bits (746), Expect = 1e-78
Identities = 146/240 (60%), Positives = 178/240 (74%), Gaps = 4/240 (1%)
Query: 541 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 600
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
Query: 601 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
Query: 660 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTS 719
+RQGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q
Sbjct: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGG 1042
Query: 720 QDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+ F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1043 GEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 121 bits (303), Expect = 3e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 235 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 288
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 289 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 338
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
Query: 339 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 389
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
Query: 390 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 447
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
Query: 448 RPSSSASTKDSES 460
S ++S+ S S
Sbjct: 292 TKSFTSSSPSSPS 304
Score = 83.2 bits (204), Expect = 9e-16
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 590 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 649
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
Query: 650 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 709
NWYEG G R GIFPI+YV+ + + P ++ A P P
Sbjct: 899 NWYEGEHHG--RVGIFPISYVEKL-----------------TPPEKAQPARPPPP----- 934
Query: 710 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 769
++ A Y++ + EL LR GD V ++++ D W+ G T + G
Sbjct: 935 -------AQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQG 987
Query: 770 TFPGNYVK 777
FP +YV+
Sbjct: 988 IFPVSYVE 995
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 7/73 (9%)
Query: 707 QQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 766
++RR TP++ + +A+Y + Q EL + GD V ++ K D W+ G
Sbjct: 855 RERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHG 907
Query: 767 QFGTFPGNYVKPL 779
+ G FP +YV+ L
Sbjct: 908 RVGIFPISYVEKL 920
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 278 bits (712), Expect = 1e-74
Identities = 203/606 (33%), Positives = 288/606 (47%), Gaps = 106/606 (17%)
Query: 237 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 291
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
Query: 292 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDW 347
PR+ ++ + P + S D + + RS P S++
Sbjct: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQ------- 221
Query: 348 EPPDKKVDTRKYRAEPKSIYE-YQPGKSSVLTNEKMSSAISPTP-EISSETPGYIYSSNF 405
P +V R+ + + E + + T ++ + P E S+ +
Sbjct: 222 --PSNQVLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLEREL 279
Query: 406 HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFI 465
+ E D DL ++E KS P Q + P+ AS S P
Sbjct: 280 AELSAELDK---DLRAIETRLPSPKSSPAPRRAPEQ-----RPPAGPASAWSSSYPH--- 328
Query: 466 PADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFG 525
A YL S + D +R D +A G
Sbjct: 329 -APYLGSARSLSPHKMADGGSPFLGRRDFVYPSSTRDPSASNGGG--------------- 372
Query: 526 DLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 585
+ R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR
Sbjct: 373 -------SPARREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGR 425
Query: 586 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 645
+GIFP Y+E+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R
Sbjct: 426 LGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIR 485
Query: 646 QVDENWYEGRIPGTSRQGIFPITYVDVIKRP----------------------------- 676
+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 486 KVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSS 545
Query: 677 --LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------D 714
+++P D +DL +SP R+ + P Q+P+ Q + + TP
Sbjct: 546 PSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTS 605
Query: 715 RSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPG 773
TSQ ++ Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPG
Sbjct: 606 SPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPG 665
Query: 774 NYVKPL 779
NYV P+
Sbjct: 666 NYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 271 bits (694), Expect = 1e-72
Identities = 144/296 (48%), Positives = 189/296 (63%), Gaps = 52/296 (17%)
Query: 536 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 595
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 596 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 655
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 656 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 684
I GT RQGIFP +YV V + P +++P D
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
Query: 685 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 724
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
Query: 725 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
Score = 38.9 bits (89), Expect = 0.019
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 528 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 585
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
Query: 586 VGIFPRTYI 594
G FP Y+
Sbjct: 318 FGTFPGNYV 326
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 607
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
Query: 668 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 726
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 564 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 608
Query: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 778
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
Score = 91.7 bits (226), Expect = 2e-18
Identities = 168/806 (20%), Positives = 295/806 (36%), Gaps = 149/806 (18%)
Query: 36 ISAVKIIPVKTVKNASGL-----VLPTDMDPTK-ICTGKGAVTLRASSSYRETPSSSPAS 89
+S +K+ +T SGL + P + P + +GK +V + +++ S S
Sbjct: 14 VSRIKVFEGQTNIETSGLPKKPEITPRSLPPKPTVSSGKPSVAPKPAAN---RASGEWDS 70
Query: 90 PQETR-QHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD 148
E R + SK GL P P + + S P RSV+P +P
Sbjct: 71 GTENRLKVTSKEGLTPYPPLQE----AGSIPVTKPELPKKPNPGLIRSVNPEIPG----- 121
Query: 149 SSPLLNEVSSSLIGTDSQAFP-----SVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 203
PL S P SVS + YPS + T+ Q K S
Sbjct: 122 RGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAPLKPVTVPPRLAGASQAKAYKS 181
Query: 204 LSD-PVSERRVGEQDSAPTQE----------KPTSPGKAIEKRAKDDSRRVVKSTQDLSD 252
L + P + V S P + PT G E+ S V+ +D
Sbjct: 182 LGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPTPSGNLAEESV--GSEMVLGLHEDPQS 239
Query: 253 VSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKS 312
P+ NT + T+ ++ + R + + P + P PR +
Sbjct: 240 PPPLPAEKPIGNT------FSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVN 293
Query: 313 EMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 372
+ + K P P + S+ + S+++ + +D +K ++ +
Sbjct: 294 GKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKA 351
Query: 373 KSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGD-LTSLENERQIYKS 431
KS V N+ + P P+ PG+ S + GD L L+ Y
Sbjct: 352 KSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMR---------GDVLVMLKQTENNYLE 395
Query: 432 VLEGGDIPLQGLSGLK--------------RPSSSASTKDSESPRHFIPADYLESTEEFI 477
+G D LS +K PS + DS +P + D+ + +
Sbjct: 396 CQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDL 455
Query: 478 RRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRK 537
+ LL K + + R G+ P ++ + +++I + K
Sbjct: 456 NLTSGEIVYLLE-----KIDTDWYRGNCRNQIGIFPANYVKV-------IIDIPEGGNGK 503
Query: 538 ----SGSEMRPAR--AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPR 591
S ++ +R A+F++ + EL +G+I+ + + +++ W GE GR GIFP
Sbjct: 504 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 563
Query: 592 TYIELLP----------------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSF 635
++E + +K + V L A +F +T ++SF
Sbjct: 564 NFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSF 623
Query: 636 RKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 695
++G+RI +L ++D +W GR+ R+GIFP +V RP P+
Sbjct: 624 KRGDRIQILERLDSDWCRGRL--QDREGIFPAVFV----RP---------------CPAE 662
Query: 696 SATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDD 755
+ + P+ ++ + ALY + +N+DEL + GDI+ +E DD
Sbjct: 663 AKSMLAIVPKGRKAK----------------ALYDFRGENEDELSFKAGDIITELESVDD 706
Query: 756 GWFVGTSRRTKQFGTFPGNYVKPLYL 781
W G + G FP NY++ L +
Sbjct: 707 DWMSG--ELMGKSGIFPKNYIQFLQI 730
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 607
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
Query: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
Query: 668 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 726
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 600 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 644
Query: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 778
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 694
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 598
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
Query: 599 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 650
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
Query: 651 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 710
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 675 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 713
Query: 711 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 770
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 714 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 755
Query: 771 FPGNYVKPLYL 781
FP NY++ L +
Sbjct: 756 FPKNYIQFLQI 766
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 563 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 617
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 618 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 676
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 529
Query: 677 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 736
+D+P + R +S V R A + YI +
Sbjct: 530 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 564
Query: 737 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 565 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 437 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 493
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 607 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 666
Query: 494 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 550
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 667 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 717
Query: 551 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 597
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 718 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 106 bits (264), Expect = 9e-23
Identities = 65/232 (28%), Positives = 117/232 (50%), Gaps = 22/232 (9%)
Query: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 607
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
Query: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
Query: 668 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-Q 726
+V+ ++ D P S + S + P ++ + SQ + + +
Sbjct: 623 NFVEPVE-----------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCE 667
Query: 727 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 778
AL+S+ + D+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 717
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 598
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 599 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 650
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
Query: 651 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 710
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 698 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 736
Query: 711 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 770
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
Query: 771 FPGNYVKPLYL 781
FP NY++ L +
Sbjct: 779 FPKNYIQFLQI 789
Score = 70.1 bits (170), Expect = 8e-12
Identities = 63/239 (26%), Positives = 106/239 (44%), Gaps = 38/239 (15%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 603
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
Query: 604 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 660
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
Query: 661 RQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQ 720
+ GIFP YV VI +D+P + R +S V R
Sbjct: 540 QIGIFPANYVKVI-----------IDIPEGGNGKRECVSS--------HCVKGSRC---- 576
Query: 721 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 577 -----VARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/167 (25%), Positives = 72/167 (43%), Gaps = 15/167 (8%)
Query: 437 DIPLQGLSGLKRPSSSASTKD---SESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRR 493
D P G + L + K+ S S + +PA++ E+ F DD D+ +
Sbjct: 630 DYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQ 689
Query: 494 LKREQEEADIAARR---HTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 550
+ E+ ++D R G+ P +L I ++ A+A +D
Sbjct: 690 IL-ERLDSDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRK--------AKALYD 740
Query: 551 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 597
F+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 741 FRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 94.7 bits (234), Expect = 3e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 618 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 677
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 678 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 735
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
Query: 736 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
Score = 69.7 bits (169), Expect = 1e-11
Identities = 71/300 (23%), Positives = 135/300 (45%), Gaps = 39/300 (13%)
Query: 492 RRLKREQEEADI---AARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAK 548
R +K+E ++ + A + +P+ + +++E +L + +R+ R +
Sbjct: 54 REIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSET---ILRTNKRGERRR----RRCQVA 106
Query: 549 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKK 607
F + Q EL L+ GDI+ + ++++ W+EG +G+ G+FP +I EL +++ +
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 166
Query: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
+ E + GD+ S +G T+ + ++ G IF
Sbjct: 167 DEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKD 221
Query: 668 TYVDVIKRPL-VKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY- 725
+ + R + V+N D++ + + AT + TPD S+T D +
Sbjct: 222 KPIKLRPRSIEVEN--DFLPVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKS 268
Query: 726 ----QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+ ++ Y QNDDEL +++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 269 KDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 542 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 597
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 598 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 636
P KA K L V L E I + N G+ E+ +
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 637 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 670
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 549 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 603
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
Query: 604 QPKKLTP 610
+PKK P
Sbjct: 336 RPKKPPP 342
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 92.4 bits (228), Expect = 1e-18
Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)
Query: 551 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 609
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 610 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 659
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 660 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 714
+ G FP +V+++ P + NP D+P S + PQ+P PD
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
Query: 715 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 772
QT Y+ L+ Y P+ DEL LR GD+V V+ K D GW+ G + + G FP
Sbjct: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
Query: 773 GNYVKP 778
N+V P
Sbjct: 234 DNFVLP 239
Score = 66.6 bits (161), Expect = 8e-11
Identities = 52/210 (24%), Positives = 98/210 (46%), Gaps = 36/210 (17%)
Query: 543 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 599
R + F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP ++ELL PP
Sbjct: 86 RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
Query: 600 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 638
+ +P KL+ +Q + + E F++ + E++ R+G
Sbjct: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
Query: 639 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 696
+ + +L + D+ W+EG G R+G+FP + V+ P +K V + S+P +
Sbjct: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPRKVVSRESAPIKE 261
Query: 697 ------ATASPQQPQAQQRRVTPDRSQTSQ 720
T+ P + P +++TS+
Sbjct: 262 PKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)
Query: 618 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 676
E + + + E+S G+ + +R V W G G R G+FP V I
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 677 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 736
L + ++P+ +RR P + Q +SY P+
Sbjct: 60 L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
Query: 737 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
DEL+L+ G+IV+++++ +DGW++G ++ Q G FP N+V+ L
Sbjct: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 83.6 bits (205), Expect = 7e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 605
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 606 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 663
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
Query: 664 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 723
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
Query: 724 S 724
S
Sbjct: 364 S 364
Score = 81.3 bits (199), Expect = 3e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 690 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 749
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
Query: 750 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 63.2 bits (152), Expect = 9e-10
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 685 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 744
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
Query: 745 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 595
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.070
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 597 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 655
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 656 IPGTSRQGIFPITYVDVIKR 675
T G+FP YV + R
Sbjct: 506 SLRTGVSGVFPGNYVTPVSR 525
Score = 35.8 bits (81), Expect = 0.16
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
Score = 33.1 bits (74), Expect = 1.0
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 671
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 32.7 bits (73), Expect = 1.3
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 594
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 545 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 605 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 660
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 661 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 708
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 676 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 735
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
Query: 736 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 725 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/63 (31%), Positives = 39/63 (61%), Gaps = 7/63 (11%)
Query: 540 SEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 592
+E RP R + Q+ EL L++GDIV+++K+ + W++G + +G+ G+FP +
Sbjct: 824 NESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGS 883
Query: 593 YIE 595
++E
Sbjct: 884 FVE 886
Score = 38.9 bits (89), Expect = 0.019
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 620 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 679
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 680 NPVDYMDLPFSSSPSRSAT 698
+ + + SR T
Sbjct: 511 ASQAKVPMSTAGQTSRGVT 529
Score = 35.4 bits (80), Expect = 0.20
Identities = 12/39 (30%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 558 ELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 594
EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 463 ELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 33.1 bits (74), Expect = 1.0
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 779
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 3.9
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 629 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 673
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 80.9 bits (198), Expect = 4e-15
Identities = 70/236 (29%), Positives = 106/236 (44%), Gaps = 26/236 (11%)
Query: 545 ARAKFDFKAQTLKELPLQKGDIVYIY-KQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKA 603
A AK+DFKA EL ++GDI+ + ++ DQNWY+ E +G+ G P+ YIE+ P
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKP----- 57
Query: 604 QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQG 663
P + + E ++K +G + S +L + + ++ R G
Sbjct: 58 HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV---LRDG 114
Query: 664 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 723
++ V+K + VDY S+S SR+ Q+ D Q Q
Sbjct: 115 AGKY-FLWVVKFNSLNELVDYHR---STSVSRN-----------QQIFLRDIEQVPQQPT 159
Query: 724 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
QAL+ + PQ D EL R GD + VM+ D W+ G Q G FP NYV P+
Sbjct: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACH--GQTGMFPRNYVTPV 213
Score = 44.3 bits (103), Expect = 4e-04
Identities = 20/60 (33%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Query: 618 EAIAKFNFNGDTQVEMSFRKGERITLL-RQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 676
EAIAK++F E+SF++G+ + +L + D+NWY+ + G + G P Y+++ P
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNG--KDGFIPKNYIEMKPHP 59
Score = 38.9 bits (89), Expect = 0.019
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 621 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 675
A F+F+ E+ FR+G+ I ++ D NW++G G + G+FP YV + R
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG--QTGMFPRNYVTPVNR 215
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 80.5 bits (197), Expect = 6e-15
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 607
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
Query: 608 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 664
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
Query: 665 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 723
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
Query: 724 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
Score = 70.5 bits (171), Expect = 6e-12
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 542 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 601
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
Query: 602 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 637
TPV E G +A + F E+ F
Sbjct: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 638 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 695
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 605
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
Query: 606 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 665
++L + F + +G+ + L W +GR +R G F
Sbjct: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
Query: 666 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 725
P + V + L S S +A Q P+ +
Sbjct: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
Query: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 79.3 bits (194), Expect = 1e-14
Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)
Query: 545 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 605 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 660
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
Query: 661 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 713
+ GIFPI +V+ ++++ + +L SS SR T++ ++ +R+V
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
Query: 714 DRSQTS 719
S T+
Sbjct: 298 QFSITT 303
Score = 77.0 bits (188), Expect = 6e-14
Identities = 75/265 (28%), Positives = 111/265 (41%), Gaps = 55/265 (20%)
Query: 549 FDFKAQTLKE----LPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604
FD + + E L K DI+ + ++D+NW EG+ +VGIFP ++E
Sbjct: 198 FDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKLGDKVGIFPILFVE--------- 248
Query: 605 PKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ-- 662
LT +LE + + V S R G TL R PG+ R+
Sbjct: 249 -PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR-GNTSTLRRG----------PGSRRKVP 296
Query: 663 GIFPIT----------------YVDVIKRPL---------VKNPVDYMDLPFSSSPSRSA 697
G F IT ++ I P+ + P++ D+P SS + +
Sbjct: 297 GQFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPMEKADVP-SSCVGQVS 355
Query: 698 T--ASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDD 755
T +P P V+ SQ + AL+SY DEL+L+ G+ V V+ KC D
Sbjct: 356 TYHPAPVSPGHSTAVVSLPGSQQHLSANMFVALHSYSAHGPDELDLQKGEGVRVLGKCQD 415
Query: 756 GWFVGTSRRTKQFGTFPGNYVKPLY 780
GW G S T + G FP NYV P++
Sbjct: 416 GWLRGVSLVTGRVGIFPNNYVIPIF 440
Score = 36.6 bits (83), Expect = 0.092
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 695 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 754
R + +P++ QA R+ P+ + +AL +Y QN +L GDI+ + + D
Sbjct: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
Query: 755 DGWFVGTSRRTKQFGTFPGNYVK 777
+ W+ G G FP + V+
Sbjct: 160 ENWYQGEINGIS--GNFPASSVE 180
Score = 34.7 bits (78), Expect = 0.35
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)
Query: 620 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 675
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
Query: 676 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 710
P ++P Y S+S S S+ S + +Q R
Sbjct: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
Score = 33.9 bits (76), Expect = 0.60
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH--HGRVGIFPRTYI 594
A + A EL LQKG+ V + + W G GRVGIFP Y+
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 620 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 678
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
Query: 679 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 724
++ D LP +S R +T A QP Q + + +
Sbjct: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
Query: 725 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
Score = 57.4 bits (137), Expect = 5e-08
Identities = 69/300 (23%), Positives = 125/300 (41%), Gaps = 46/300 (15%)
Query: 492 RRLKREQEEAD----IAARRHTGVIPTHHQFIT-NERFGDLLNIDDTAKRKSGSEMRPAR 546
+ +KRE E D I RH V + T G + T K ++ R +
Sbjct: 55 KEIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCK 114
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 606
F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL--------- 165
Query: 607 KLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFP 666
+V + GE D++ ++ I L V E G + T + I
Sbjct: 166 -----EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPKKIRG 213
Query: 667 ITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPDRSQT 718
I + D+ K VK L +S S + P++ P+ Q +T ++
Sbjct: 214 IGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEG 266
Query: 719 SQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNY 775
Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G FP N+
Sbjct: 267 KIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVFPDNF 324
Score = 36.6 bits (83), Expect = 0.092
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 722 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 779
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
Score = 35.8 bits (81), Expect = 0.16
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 2/67 (2%)
Query: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKA 603
R F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K
Sbjct: 275 RTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
Query: 604 QPKKLTP 610
PK P
Sbjct: 335 FPKPKKP 341
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 78.6 bits (192), Expect = 2e-14
Identities = 61/235 (25%), Positives = 99/235 (42%), Gaps = 37/235 (15%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 606
A + +++ +L Q+GD++ + K+ D +W+ G + G+FP Y+ L
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 607 KLTPV-QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ- 662
K + + E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 663 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 722
G FP YV ++ SP S + P +S +
Sbjct: 1126 GWFPANYVKLL------------------SPGTSKITPTEPP----------KSTALAAV 1157
Query: 723 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+Y Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 69.7 bits (169), Expect = 1e-11
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 54/254 (21%)
Query: 545 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 603
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 604 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 648
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 649 ENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQ 708
+W+ G + + G+FP YV + S TA ++
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYVRL------------------KDSEGSGTAGKTGSLGKK 1075
Query: 709 RRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RT 765
+ Q + SY ++L L G ++ + +K GW+ G + +
Sbjct: 1076 PEIA-------------QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKK 1122
Query: 766 KQFGTFPGNYVKPL 779
+Q G FP NYVK L
Sbjct: 1123 RQIGWFPANYVKLL 1136
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 443 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 497
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 498 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 545
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 600
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 601 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 656
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 657 PGTSRQGIFPITYV 670
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/175 (28%), Positives = 80/175 (45%), Gaps = 26/175 (14%)
Query: 609 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 662
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQG--QK 958
Query: 663 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 722
G FP +YV +I P+ K+ MD S SP A +RV ++
Sbjct: 959 GWFPKSYVKLISGPIRKSTS--MDSGSSESP------------ASLKRVASPAAKPVVSG 1004
Query: 723 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+ A+Y+Y +L + GD++ V +K D W+ GT + G FP NYV+
Sbjct: 1005 EEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTV--GDKAGVFPSNYVR 1056
Score = 53.9 bits (128), Expect = 6e-07
Identities = 130/660 (19%), Positives = 246/660 (37%), Gaps = 136/660 (20%)
Query: 190 LLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----EKPTSPGKAIEKRAKDDSRRVV 244
LL+ R++Q+RL+ L ER+ E+ + EK + +E++ +++ R+
Sbjct: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRK-- 429
Query: 245 KSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSP 304
++ E +R +W R+ +L + R ED
Sbjct: 430 -------EIERREAAKRELERQRQLEW-----------ERNRRQELLNQRNKEQED---- 467
Query: 305 LSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPK 364
+ V ++K + + E + + L + + +++R + E +K + R
Sbjct: 468 IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELR------- 520
Query: 365 SIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFH-----AVKRESDGAP--- 416
I E + + +++M + P +I ++ + ++ H +KR +
Sbjct: 521 -IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELAR 579
Query: 417 ----GDLTSLENERQIYKSVLEGGDIPLQGLSGLK-----------RPSSSASTKDSESP 461
L +E E +S L+ DI L L+ + + K E
Sbjct: 580 QHLRDQLDEVEKET---RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE 636
Query: 462 RHFIPADYLESTEEFIRRRHDDKEKL----------------LADQRRLKREQ------- 498
R I LE +E +RR +++K L ++ +LKRE+
Sbjct: 637 RKIIE---LEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693
Query: 499 -EEADIAARRHTGVIPTHHQ----------FITNERFGDLLNIDDTAKRKSGSEMRPARA 547
E+ A+ G + HQ + T E+ G L T + ++ RA
Sbjct: 694 EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK-GPL-----TISAQENVKVVYYRA 747
Query: 548 KFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLPPA 600
+ F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRIPG 658
E P K V + A A +T ++ E T NW + P
Sbjct: 808 EVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTWPT 859
Query: 659 TSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 717
++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 860 STNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV------ 913
Query: 718 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+ QALY + + D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 914 ---EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 549 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 34.3 bits (77), Expect = 0.46
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 15/92 (16%)
Query: 701 PQQPQAQQRRVTPDR------SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------V 747
P +P Q T ++ +Q + + Y+ALY + ++ DE+ ++ GDI V
Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 748 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
D + + GW G + + G FP NY + +
Sbjct: 775 DESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 78.6 bits (192), Expect = 2e-14
Identities = 61/235 (25%), Positives = 99/235 (42%), Gaps = 37/235 (15%)
Query: 547 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPK 606
A + +++ +L Q+GD++ + K+ D +W+ G + G+FP Y+ L
Sbjct: 1009 AMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAG 1067
Query: 607 KLTPV-QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ- 662
K + + E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ
Sbjct: 1068 KTGSLGKKPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQI 1125
Query: 663 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 722
G FP YV ++ SP S + P +S +
Sbjct: 1126 GWFPANYVKLL------------------SPGTSKITPTEPP----------KSTALAAV 1157
Query: 723 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+Y Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1158 CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 69.7 bits (169), Expect = 1e-11
Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 54/254 (21%)
Query: 545 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 603
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 604 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 648
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 649 ENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQ 708
+W+ G + + G+FP YV + S TA ++
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYVRL------------------KDSEGSGTAGKTGSLGKK 1075
Query: 709 RRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RT 765
+ Q + SY ++L L G ++ + +K GW+ G + +
Sbjct: 1076 PEIA-------------QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKK 1122
Query: 766 KQFGTFPGNYVKPL 779
+Q G FP NYVK L
Sbjct: 1123 RQIGWFPANYVKLL 1136
Score = 64.7 bits (156), Expect = 3e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 443 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 497
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 498 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 545
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 600
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 601 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 656
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 657 PGTSRQGIFPITYV 670
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 58.2 bits (139), Expect = 3e-08
Identities = 50/175 (28%), Positives = 80/175 (45%), Gaps = 26/175 (14%)
Query: 609 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 662
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQG--QK 958
Query: 663 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDL 722
G FP +YV +I P+ K+ MD S SP A +RV ++
Sbjct: 959 GWFPKSYVKLISGPIRKSTS--MDSGSSESP------------ASLKRVASPAAKPVVSG 1004
Query: 723 FSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+ A+Y+Y +L + GD++ V +K D W+ GT + G FP NYV+
Sbjct: 1005 EEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWTGTV--GDKAGVFPSNYVR 1056
Score = 53.9 bits (128), Expect = 6e-07
Identities = 130/660 (19%), Positives = 246/660 (37%), Gaps = 136/660 (20%)
Query: 190 LLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----EKPTSPGKAIEKRAKDDSRRVV 244
LL+ R++Q+RL+ L ER+ E+ + EK + +E++ +++ R+
Sbjct: 372 LLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRK-- 429
Query: 245 KSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSP 304
++ E +R +W R+ +L + R ED
Sbjct: 430 -------EIERREAAKRELERQRQLEW-----------ERNRRQELLNQRNKEQED---- 467
Query: 305 LSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPK 364
+ V ++K + + E + + L + + +++R + E +K + R
Sbjct: 468 IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELR------- 520
Query: 365 SIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFH-----AVKRESDGAP--- 416
I E + + +++M + P +I ++ + ++ H +KR +
Sbjct: 521 -IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELAR 579
Query: 417 ----GDLTSLENERQIYKSVLEGGDIPLQGLSGLK-----------RPSSSASTKDSESP 461
L +E E +S L+ DI L L+ + + K E
Sbjct: 580 QHLRDQLDEVEKET---RSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQE 636
Query: 462 RHFIPADYLESTEEFIRRRHDDKEKL----------------LADQRRLKREQ------- 498
R I LE +E +RR +++K L ++ +LKRE+
Sbjct: 637 RKIIE---LEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDG 693
Query: 499 -EEADIAARRHTGVIPTHHQ----------FITNERFGDLLNIDDTAKRKSGSEMRPARA 547
E+ A+ G + HQ + T E+ G L T + ++ RA
Sbjct: 694 EEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEK-GPL-----TISAQENVKVVYYRA 747
Query: 548 KFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLPPA 600
+ F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 748 LYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPEN 807
Query: 601 EKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRIPG 658
E P K V + A A +T ++ E T NW + P
Sbjct: 808 EVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTWPT 859
Query: 659 TSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQ 717
++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 860 STNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV------ 913
Query: 718 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
+ QALY + + D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 914 ---EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 549 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 604
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 34.3 bits (77), Expect = 0.46
Identities = 24/92 (26%), Positives = 43/92 (46%), Gaps = 15/92 (16%)
Query: 701 PQQPQAQQRRVTPDR------SQTSQDLFSYQALYSYIPQNDDELELRDGDI-------V 747
P +P Q T ++ +Q + + Y+ALY + ++ DE+ ++ GDI V
Sbjct: 715 PAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWV 774
Query: 748 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
D + + GW G + + G FP NY + +
Sbjct: 775 DESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,002,185
Number of Sequences: 37866
Number of extensions: 1594969
Number of successful extensions: 7941
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 317
Number of HSP's that attempted gapping in prelim test: 6407
Number of HSP's gapped (non-prelim): 1487
length of query: 781
length of database: 18,247,518
effective HSP length: 110
effective length of query: 671
effective length of database: 14,082,258
effective search space: 9449195118
effective search space used: 9449195118
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.