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Search of human proteins with 78000163
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
(1292 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 2601 0.0
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 1862 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 1440 0.0
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 1342 0.0
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 1025 0.0
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 1023 0.0
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 877 0.0
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 340 4e-93
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 282 1e-75
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 277 4e-74
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 277 5e-74
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 240 7e-63
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 238 3e-62
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 199 2e-50
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 199 2e-50
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 198 3e-50
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 198 3e-50
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 88 6e-17
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 86 2e-16
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 84 9e-16
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 84 9e-16
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 84 9e-16
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 80 1e-14
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 74 9e-13
gi|39930351 dynamin binding protein [Homo sapiens] 70 1e-11
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 67 1e-10
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 67 1e-10
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 67 1e-10
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 65 5e-10
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 65 5e-10
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 2601 bits (6742), Expect = 0.0
Identities = 1292/1292 (100%), Positives = 1292/1292 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 421 FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK
Sbjct: 421 FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
Query: 481 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 540
SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP
Sbjct: 481 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 540
Query: 541 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 600
GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR
Sbjct: 541 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 600
Query: 601 KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA
Sbjct: 601 KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
Query: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA
Sbjct: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
Query: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL
Sbjct: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
Query: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 840
LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG
Sbjct: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 840
Query: 841 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 900
IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV
Sbjct: 841 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 900
Query: 901 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHS 960
DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHS
Sbjct: 901 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHS 960
Query: 961 KLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDH 1020
KLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDH
Sbjct: 961 KLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDH 1020
Query: 1021 LALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGV 1080
LALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGV
Sbjct: 1021 LALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGV 1080
Query: 1081 HTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGP 1140
HTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGP
Sbjct: 1081 HTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGP 1140
Query: 1141 GGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE 1200
GGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE
Sbjct: 1141 GGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE 1200
Query: 1201 QAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 1260
QAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV
Sbjct: 1201 QAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 1260
Query: 1261 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
MEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 1261 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 1862 bits (4823), Expect = 0.0
Identities = 938/977 (96%), Positives = 943/977 (96%), Gaps = 22/977 (2%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 421 FPELPEIQQTSEEDNP---YTPTYQFPAST--------------PSPKSE-----DDDSD 458
FPELPEIQQTSEE +P + + P+ S+ DDDSD
Sbjct: 421 FPELPEIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPPTSASQVAGTADDDSD 480
Query: 459 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 518
LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP
Sbjct: 481 LYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEP 540
Query: 519 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 578
PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK
Sbjct: 541 PDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGK 600
Query: 579 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 638
PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA
Sbjct: 601 PPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSA 660
Query: 639 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 698
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 661 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 720
Query: 699 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 758
LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA
Sbjct: 721 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 780
Query: 759 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 818
RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 781 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 840
Query: 819 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 878
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 841 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 900
Query: 879 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 938
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 901 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 960
Query: 939 DLPFSSSPSRSATASPQ 955
DLPFSSSPSRSATASPQ
Sbjct: 961 DLPFSSSPSRSATASPQ 977
Score = 367 bits (941), Expect = e-101
Identities = 181/201 (90%), Positives = 185/201 (92%), Gaps = 8/201 (3%)
Query: 1092 FLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCL 1151
++ LP SS S S+ + QPWREESGQYERKAERGAGERGPGGPKISKKSCL
Sbjct: 959 YMDLPFSSSPSR--------SATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCL 1010
Query: 1152 KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG 1211
KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG
Sbjct: 1011 KPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGG 1070
Query: 1212 SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 1271
SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG
Sbjct: 1071 SQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVG 1130
Query: 1272 TSRRTKQFGTFPGNYVKPLYL 1292
TSRRTKQFGTFPGNYVKPLYL
Sbjct: 1131 TSRRTKQFGTFPGNYVKPLYL 1151
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
Query: 1286 YVKPL 1290
Y++ L
Sbjct: 868 YIELL 872
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
Query: 846 YIELL 850
Y++ L
Sbjct: 1145 YVKPL 1149
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 877 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 933
Query: 1276 TKQFGTFPGNYV 1287
T + G FP YV
Sbjct: 934 TSRQGIFPITYV 945
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 855 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 911
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1075 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1134
Query: 912 TSRQGIFPITYV 923
T + G FP YV
Sbjct: 1135 TKQFGTFPGNYV 1146
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 1440 bits (3727), Expect = 0.0
Identities = 766/960 (79%), Positives = 775/960 (80%), Gaps = 149/960 (15%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSS P+S E R S
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSS-------------------PASPQETRQHESKPG 101
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
+P +A +R S A ++ AQP + Y
Sbjct: 102 ---LEPEPSSADEWRL---------SSSADANGNAQPSSLAAKGYR-------------- 135
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
P +P+ S QRWPHHSQPARASGSFAPISQTPPS
Sbjct: 136 ------SVHPNLPSDKS------------------QRWPHHSQPARASGSFAPISQTPPS 171
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 172 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 231
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 232 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 291
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD
Sbjct: 292 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD------------ 339
Query: 421 FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
DDSDLYSPRYSFSEDTKSPLSVPRSK
Sbjct: 340 ----------------------------------DDSDLYSPRYSFSEDTKSPLSVPRSK 365
Query: 481 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 540
SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP
Sbjct: 366 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 425
Query: 541 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 600
GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR
Sbjct: 426 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 485
Query: 601 KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
K SSAISPTPEISSETPGYIYSSNFHA
Sbjct: 486 K----------------------------------SSAISPTPEISSETPGYIYSSNFHA 511
Query: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA
Sbjct: 512 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 571
Query: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL
Sbjct: 572 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 631
Query: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 840
LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG
Sbjct: 632 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 691
Query: 841 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 900
IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV
Sbjct: 692 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 751
Query: 901 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHS 960
DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ S HS
Sbjct: 752 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHS 811
Score = 168 bits (425), Expect = 4e-41
Identities = 79/79 (100%), Positives = 79/79 (100%)
Query: 1214 QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS 1273
QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS
Sbjct: 827 QPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTS 886
Query: 1274 RRTKQFGTFPGNYVKPLYL 1292
RRTKQFGTFPGNYVKPLYL
Sbjct: 887 RRTKQFGTFPGNYVKPLYL 905
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 639 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 696
Query: 1286 YVKPL 1290
Y++ L
Sbjct: 697 YIELL 701
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 839 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 898
Query: 846 YIELL 850
Y++ L
Sbjct: 899 YVKPL 903
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 706 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 762
Query: 1276 TKQFGTFPGNYV 1287
T + G FP YV
Sbjct: 763 TSRQGIFPITYV 774
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 1342 bits (3474), Expect = 0.0
Identities = 731/966 (75%), Positives = 737/966 (76%), Gaps = 219/966 (22%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 88
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 89 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 148
Query: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
Sbjct: 149 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 208
Query: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 209 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 268
Query: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 269 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 328
Query: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD
Sbjct: 329 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD------------ 376
Query: 421 FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
DDSDLYSPRYSFSEDTKSPLSVPRSK
Sbjct: 377 ----------------------------------DDSDLYSPRYSFSEDTKSPLSVPRSK 402
Query: 481 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 540
SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE
Sbjct: 403 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE--------- 453
Query: 541 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 600
PK I++Y PG S+L
Sbjct: 454 ----------------------------------------PKSIYEYQPGKSSVL----- 468
Query: 601 KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
TN EKM SSAISPTPEISSETPGYIYSSNFHA
Sbjct: 469 -TN----------------EKM-------------SSAISPTPEISSETPGYIYSSNFHA 498
Query: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA
Sbjct: 499 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 558
Query: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
DYLESTEEFIR RRH
Sbjct: 559 DYLESTEEFIR---------------------------RRH------------------- 572
Query: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 840
DD EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG
Sbjct: 573 ---DD-------KEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 622
Query: 841 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 900
IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV
Sbjct: 623 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 682
Query: 901 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQF-SSH 959
DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ +
Sbjct: 683 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 742
Query: 960 SKLITP 965
+ +TP
Sbjct: 743 QRRVTP 748
Score = 170 bits (430), Expect = 9e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 737 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 796
Query: 1273 SRRTKQFGTFPGNYVKPLYL 1292
SRRTKQFGTFPGNYVKPLYL
Sbjct: 797 SRRTKQFGTFPGNYVKPLYL 816
Score = 34.3 bits (77), Expect = 0.79
Identities = 93/457 (20%), Positives = 153/457 (33%), Gaps = 118/457 (25%)
Query: 941 PFSSSPSRSATA-------SPQFSSHSKLITPAPSSLPHSRRALSPEMHAVTS------- 986
P S P+R++ + P FS L+ PAP L RR P++ S
Sbjct: 187 PHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDL---RRVSEPDLTGAVSSTDSSPL 243
Query: 987 --EWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRP 1044
E S +G + +++ P P +I N + L LS S SD
Sbjct: 244 LNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLS----SLSDPV 299
Query: 1045 TPRSVASPLALPSPHK----------------------TYSLAPTSQAS----------- 1071
+ R V + P+ K T L+ S
Sbjct: 300 SERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERS 359
Query: 1072 -------------LHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLS-DAFSSQSKR 1117
L+ + D +++P +D+ L + S S +S + + +S
Sbjct: 360 KDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSAT 419
Query: 1118 QPWREESGQYERKAERGAGERGPGGPKI-SKKSCLKPSDVVR-------CLSTEQRLSDL 1169
P S + +ER E P K+ ++K +P + L+ E+ S +
Sbjct: 420 LPLPARSSSLKSSSERNDWE--PPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAI 477
Query: 1170 N-TPEESR--PGKPLGSAFPGSEAE-----------QTERH------RGGE-----QAGR 1204
+ TPE S PG S F + E + ER GG+ +G
Sbjct: 478 SPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGL 537
Query: 1205 KAARRGGSQQPQAQQRRVTPD-----------RSQTSQDLFSYQALYSYIPQNDDELELR 1253
K S + R P R +++ +A + + Q EL L+
Sbjct: 538 KRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQ 597
Query: 1254 DGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
GDIV + ++ D W+ G + G FP Y++ L
Sbjct: 598 KGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIELL 632
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 750 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 809
Query: 846 YIELL 850
Y++ L
Sbjct: 810 YVKPL 814
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 637 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 693
Query: 1276 TKQFGTFPGNYV 1287
T + G FP YV
Sbjct: 694 TSRQGIFPITYV 705
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 1025 bits (2649), Expect = 0.0
Identities = 584/860 (67%), Positives = 608/860 (70%), Gaps = 155/860 (18%)
Query: 114 LSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD-ATSSSAAQPEVIVVPLYLVNTDRG 172
+SS D A + LA P QD AT+ + V + V T +
Sbjct: 1 MSSECDGGSKAVMNGLA-----------PGSNGQDKATADPLRARSISAVKIIPVKTVKN 49
Query: 173 QEGTARPPTPLGPL------GCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPAR 226
G P T + P G V +++ +P + P H + +P+
Sbjct: 50 ASGLVLP-TDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSS 108
Query: 227 ASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGT 286
A S + P L A + R V P+L S DSSPLLNEVSSSLIGT
Sbjct: 109 ADEWRLSSSADANGNAQPSSL---AAKGYRSV-HPNLPSD-KSQDSSPLLNEVSSSLIGT 163
Query: 287 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 346
DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE
Sbjct: 164 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 223
Query: 347 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 406
KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN
Sbjct: 224 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 283
Query: 407 RDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSF 466
RD DDSDLYSPRYSF
Sbjct: 284 RD----------------------------------------------DDSDLYSPRYSF 297
Query: 467 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 526
SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR
Sbjct: 298 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 357
Query: 527 KYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWD 586
KYRAE PK I++
Sbjct: 358 KYRAE-------------------------------------------------PKSIYE 368
Query: 587 YTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEIS 646
Y PG S+L TN EKM SSAISPTPEIS
Sbjct: 369 YQPGKSSVL------TN----------------EKM-------------SSAISPTPEIS 393
Query: 647 SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 706
SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA
Sbjct: 394 SETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSA 453
Query: 707 STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP 766
STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP
Sbjct: 454 STKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIP 513
Query: 767 THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 826
THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI
Sbjct: 514 THHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 573
Query: 827 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 886
DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM
Sbjct: 574 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 633
Query: 887 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 946
SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP
Sbjct: 634 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 693
Query: 947 SRSATASPQF-SSHSKLITP 965
SRSATASPQ + + +TP
Sbjct: 694 SRSATASPQQPQAQQRRVTP 713
Score = 297 bits (760), Expect = 5e-80
Identities = 158/194 (81%), Positives = 165/194 (85%), Gaps = 8/194 (4%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 174
Query: 181 TPLGPLGCV--PTI 192
+ P + PTI
Sbjct: 175 SSAYPSTTIVNPTI 188
Score = 170 bits (430), Expect = 9e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 702 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 761
Query: 1273 SRRTKQFGTFPGNYVKPLYL 1292
SRRTKQFGTFPGNYVKPLYL
Sbjct: 762 SRRTKQFGTFPGNYVKPLYL 781
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 535 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 592
Query: 1286 YVKPL 1290
Y++ L
Sbjct: 593 YIELL 597
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 715 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 774
Query: 846 YIELL 850
Y++ L
Sbjct: 775 YVKPL 779
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 602 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 658
Query: 1276 TKQFGTFPGNYV 1287
T + G FP YV
Sbjct: 659 TSRQGIFPITYV 670
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 1023 bits (2646), Expect = 0.0
Identities = 551/698 (78%), Positives = 557/698 (79%), Gaps = 131/698 (18%)
Query: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
Query: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
Query: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTP 448
ERSKDWYKTMFKQIHKLNRD
Sbjct: 225 ERSKDWYKTMFKQIHKLNRD---------------------------------------- 244
Query: 449 SPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 508
DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK
Sbjct: 245 ------DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 298
Query: 509 SSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWY 568
SSSERNDWEPPDKKVDTRKYRAE
Sbjct: 299 SSSERNDWEPPDKKVDTRKYRAE------------------------------------- 321
Query: 569 KFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKA 628
PK I++Y PG S+L TN EKM
Sbjct: 322 ------------PKSIYEYQPGKSSVL------TN----------------EKM------ 341
Query: 629 PSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 688
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG
Sbjct: 342 -------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 394
Query: 689 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK 748
GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK
Sbjct: 395 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK 454
Query: 749 REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 808
REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT
Sbjct: 455 REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 514
Query: 809 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 868
LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE
Sbjct: 515 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 574
Query: 869 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 928
YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR
Sbjct: 575 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 634
Query: 929 PLVKNPVDYMDLPFSSSPSRSATASPQF-SSHSKLITP 965
PLVKNPVDYMDLPFSSSPSRSATASPQ + + +TP
Sbjct: 635 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 672
Score = 197 bits (500), Expect = 7e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
Query: 181 TPLGPLGCV--PTI 192
+ P + PTI
Sbjct: 134 SSAYPSTTIVNPTI 147
Score = 170 bits (430), Expect = 9e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 661 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 720
Query: 1273 SRRTKQFGTFPGNYVKPLYL 1292
SRRTKQFGTFPGNYVKPLYL
Sbjct: 721 SRRTKQFGTFPGNYVKPLYL 740
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 494 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 551
Query: 1286 YVKPL 1290
Y++ L
Sbjct: 552 YIELL 556
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 674 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 733
Query: 846 YIELL 850
Y++ L
Sbjct: 734 YVKPL 738
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 561 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 617
Query: 1276 TKQFGTFPGNYV 1287
T + G FP YV
Sbjct: 618 TSRQGIFPITYV 629
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 877 bits (2266), Expect = 0.0
Identities = 494/698 (70%), Positives = 500/698 (71%), Gaps = 187/698 (26%)
Query: 269 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 328
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
Query: 329 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 388
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
Query: 389 ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTP 448
ERSKDWYKTMFKQIHKLNRD
Sbjct: 225 ERSKDWYKTMFKQIHKLNRD---------------------------------------- 244
Query: 449 SPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 508
DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK
Sbjct: 245 ------DDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLK 298
Query: 509 SSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWY 568
SSSERNDWEPPDKKVDTRKYRAE
Sbjct: 299 SSSERNDWEPPDKKVDTRKYRAE------------------------------------- 321
Query: 569 KFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNKA 628
PK I++Y PG S+L TN EKM
Sbjct: 322 ------------PKSIYEYQPGKSSVL------TN----------------EKM------ 341
Query: 629 PSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 688
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG
Sbjct: 342 -------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEG 394
Query: 689 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLK 748
GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 395 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR----------------- 437
Query: 749 REQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 808
RRH DD EMRPARAKFDFKAQT
Sbjct: 438 ----------RRH----------------------DD-------KEMRPARAKFDFKAQT 458
Query: 809 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 868
LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE
Sbjct: 459 LKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLE 518
Query: 869 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 928
YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR
Sbjct: 519 YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 578
Query: 929 PLVKNPVDYMDLPFSSSPSRSATASPQF-SSHSKLITP 965
PLVKNPVDYMDLPFSSSPSRSATASPQ + + +TP
Sbjct: 579 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 616
Score = 197 bits (500), Expect = 7e-50
Identities = 117/194 (60%), Positives = 124/194 (63%), Gaps = 49/194 (25%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
Query: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP DEWRLSSSADA
Sbjct: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKP---------DEWRLSSSADA 79
Query: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
NGNAQPSSLAAKGYRSVHPNLPSDKSQD++ P + V L+ TD + P
Sbjct: 80 NGNAQPSSLAAKGYRSVHPNLPSDKSQDSS------PLLNEVSSSLIGTDSQAFPSVSKP 133
Query: 181 TPLGPLGCV--PTI 192
+ P + PTI
Sbjct: 134 SSAYPSTTIVNPTI 147
Score = 170 bits (430), Expect = 9e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 605 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 664
Query: 1273 SRRTKQFGTFPGNYVKPLYL 1292
SRRTKQFGTFPGNYVKPLYL
Sbjct: 665 SRRTKQFGTFPGNYVKPLYL 684
Score = 33.1 bits (74), Expect = 1.8
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 1226 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1285
R +++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 438 RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 495
Query: 1286 YVKPL 1290
Y++ L
Sbjct: 496 YIELL 500
Score = 32.7 bits (73), Expect = 2.3
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 618 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 677
Query: 846 YIELL 850
Y++ L
Sbjct: 678 YVKPL 682
Score = 32.0 bits (71), Expect = 3.9
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 505 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 561
Query: 1276 TKQFGTFPGNYV 1287
T + G FP YV
Sbjct: 562 TSRQGIFPITYV 573
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 340 bits (873), Expect = 4e-93
Identities = 248/703 (35%), Positives = 344/703 (48%), Gaps = 133/703 (18%)
Query: 249 PPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVN 308
P + + R V P+L S T S +N S + S S SAY +N
Sbjct: 10 PDSAKGFRSV-RPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLN 66
Query: 309 PTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVK 368
+IV+ Q S S + D + P EKR V+K
Sbjct: 67 SSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIK 114
Query: 369 STQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELP 425
+ +DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y +
Sbjct: 115 APHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGL 174
Query: 426 EIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSY 485
S + +P T + P KS D+S + +D SP+ P
Sbjct: 175 YNPPYSAQSHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP---- 221
Query: 486 IDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSV 545
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 222 -------------PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI 268
Query: 546 LTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLD 605
L +E+ + I+P++IDL+NEPWYKFFSELEFG+PPPKK DY +D + +
Sbjct: 269 LQHERPTDRINPDDIDLENEPWYKFFSELEFGRPPPKKPLDYV---------QDHSSGVF 319
Query: 606 KDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRES 665
+ SL Q+ ++ LE+ P SSA +S+F +R+S
Sbjct: 320 NEASLYQSSIDRSLER------------PMSSASM--------------ASDFRK-RRKS 352
Query: 666 DGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLES 725
+ A G L ++ S G + L G S S ++S+ S S
Sbjct: 353 EPAVGPPRGLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS------------ 397
Query: 726 TEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDD 785
R D+E + R ++ + + ER G
Sbjct: 398 -------RAKDRE------------------SPRSYSSTLTDMGRSAPRERRGT------ 426
Query: 786 TAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRT 845
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +
Sbjct: 427 -----PEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPIS 481
Query: 846 YIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW 904
Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NW
Sbjct: 482 YVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNW 541
Query: 905 YEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
YEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 542 YEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 583
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 612 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 666
Score = 42.0 bits (97), Expect = 0.004
Identities = 53/212 (25%), Positives = 79/212 (37%), Gaps = 37/212 (17%)
Query: 1080 VHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGE-R 1138
V SSG+ ++ L S+ L SS S +R+ RK+E G R
Sbjct: 311 VQDHSSGVFNEASLY-----QSSIDRSLERPMSSASMASDFRKR-----RKSEPAVGPPR 360
Query: 1139 GPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRG 1198
G G S+ S P V S+ + S P + P S +
Sbjct: 361 GLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLT---- 413
Query: 1199 GEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIV 1258
GR A R +RR TP++ + +A+Y + Q EL + GD V
Sbjct: 414 --DMGRSAPR----------ERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTV 456
Query: 1259 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
++ K D W+ G + G FP +YV+ L
Sbjct: 457 YILRKIDQNWYEG--EHHGRVGIFPISYVEKL 486
Score = 38.1 bits (87), Expect = 0.055
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 511 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 561
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 282 bits (722), Expect = 1e-75
Identities = 227/695 (32%), Positives = 315/695 (45%), Gaps = 160/695 (23%)
Query: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 40 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 94
Query: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Q S S + D + P EKR V+K+
Sbjct: 95 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 145
Query: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y + S +
Sbjct: 146 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 205
Query: 434 DNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVK 493
+P T + P KS D+S + +D SP+ P
Sbjct: 206 SHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP------------ 244
Query: 494 RSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSR 553
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 245 -----PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER--- 296
Query: 554 DISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQT 613
PPPKK DY +D + + + SL Q+
Sbjct: 297 -------------------------PPPKKPLDYV---------QDHSSGVFNEASLYQS 322
Query: 614 ELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 673
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 323 SIDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPR 355
Query: 674 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 733
L ++ S G + L G S S ++S+ S S R
Sbjct: 356 GLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------R 393
Query: 734 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 793
D+E + R ++ + + ER G
Sbjct: 394 AKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEK 424
Query: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 425 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 484
Query: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 485 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 544
Query: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 545 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 578
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 607 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 42.0 bits (97), Expect = 0.004
Identities = 53/212 (25%), Positives = 79/212 (37%), Gaps = 37/212 (17%)
Query: 1080 VHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAGE-R 1138
V SSG+ ++ L S+ L SS S +R+ RK+E G R
Sbjct: 306 VQDHSSGVFNEASLY-----QSSIDRSLERPMSSASMASDFRKR-----RKSEPAVGPPR 355
Query: 1139 GPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRG 1198
G G S+ S P V S+ + S P + P S +
Sbjct: 356 GLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLT---- 408
Query: 1199 GEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIV 1258
GR A R +RR TP++ + +A+Y + Q EL + GD V
Sbjct: 409 --DMGRSAPR----------ERRGTPEKEKLPA-----KAVYDFKAQTSKELSFKKGDTV 451
Query: 1259 DVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
++ K D W+ G + G FP +YV+ L
Sbjct: 452 YILRKIDQNWYEG--EHHGRVGIFPISYVEKL 481
Score = 38.1 bits (87), Expect = 0.055
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 506 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
Score = 37.7 bits (86), Expect = 0.072
Identities = 103/497 (20%), Positives = 182/497 (36%), Gaps = 76/497 (15%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQ-------DATSSSAA 155
P SA WR + + NG+A SSLAAKG+RSV PNL +S + S A
Sbjct: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
Query: 156 ----------QPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFP 205
P +P L ++ Q GT+ T P ++ T S++ PL +
Sbjct: 68 SPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQH-AQSLDGTTSSSIPL-YR 125
Query: 206 TLDDFIPPHLQRWPHHS--QPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDL 263
+ ++ + + PH+ P SG I T P + + V +PD
Sbjct: 126 SSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT---VDRPKDWYKTMFKQIHMVHKPD- 181
Query: 264 TGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKR 323
D + + N + G + + + S P++ T P + H+
Sbjct: 182 -------DDTDMYNTPYTYNAGLYNPPYSAQSHPAA---KTQTYRP--LSKSHSDNSPNA 229
Query: 324 LSSLSDPVSERRV-------GEQDSAPTQEKPTSP--GKAIEKRAKDDSRRVVKSTQDLS 374
S PV V +D + T++ P K ++ + + R + + S
Sbjct: 230 FKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKS 289
Query: 375 DVSMDEVGIPLRNTERSKDWYKTMFKQ--IHKLNRDTPEENPYFPTYKFPELPEIQQTSE 432
+ E P + + +D +F + +++ + D E P + + +++
Sbjct: 290 SILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 349
Query: 433 EDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVV 492
P AS SP D + SF+ + SP S R+K D E
Sbjct: 350 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFT--SSSPSSPSRAK------DRESPR 401
Query: 493 KRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 552
S+TL RS+ P +++ K + K++Y+++ S L+ +K
Sbjct: 402 SYSSTLTDMGRSA------------PRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGD 449
Query: 553 RDISPEEIDLKNEPWYK 569
+ID + WY+
Sbjct: 450 TVYILRKID---QNWYE 463
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 277 bits (709), Expect = 4e-74
Identities = 231/714 (32%), Positives = 323/714 (45%), Gaps = 145/714 (20%)
Query: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
Query: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Q S S + D + P EKR V+K+
Sbjct: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Query: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
+DE GIP +R T +R KDWYKTMFKQIH +++ + + Y Y + S +
Sbjct: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 222
Query: 434 DNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVK 493
+P T + P KS D+S + +D SP+ P
Sbjct: 223 SHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP------------ 261
Query: 494 RSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSR 553
P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+
Sbjct: 262 -----PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSI-------- 308
Query: 554 DISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQT 613
L+ +PPP P + +PRE + L
Sbjct: 309 --------------------LQHERPPP------LPTTPTPVPREPGRKPLSSS------ 336
Query: 614 ELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 673
++ + +PS P+S A PTP SS P S K+ D +
Sbjct: 337 -------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL---SPTRPPKKPLDYVQDHSS 381
Query: 674 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 733
+ NE +Y+S ++ L+RP SSAS +F +RR
Sbjct: 382 GVFNEASLYQSSID---------RSLERPMSSASM-----------------ASDFRKRR 415
Query: 734 HDDKE----KLLADQRRLKREQEEADIAA------RRHTGVIPTHHQFITNERF-----G 778
+ + L DQ + D+ + T P+ +
Sbjct: 416 KSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSS 475
Query: 779 DLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 834
L ++ +A R+ E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGE
Sbjct: 476 TLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE 535
Query: 835 HHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGER 893
HHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R
Sbjct: 536 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDR 595
Query: 894 ITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 596 VILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 648
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 677 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 53.1 bits (126), Expect = 2e-06
Identities = 74/296 (25%), Positives = 111/296 (37%), Gaps = 48/296 (16%)
Query: 996 PGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLAL 1055
PG+ S+ PPLP + P P S L ++ S P PRS A +
Sbjct: 303 PGKSSILQHERPPPLPTTPT----PVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSS 358
Query: 1056 PSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQS 1115
+P +L+PT ++ V SSG+ ++ L S+ L SS S
Sbjct: 359 RAP----ALSPTRPPKKPLDY---VQDHSSGVFNEASLY-----QSSIDRSLERPMSSAS 406
Query: 1116 KRQPWREESGQYERKAERGAGE-RGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEE 1174
+R+ RK+E G RG G S+ S P V S+ +
Sbjct: 407 MASDFRKR-----RKSEPAVGPPRGLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSP 458
Query: 1175 SRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLF 1234
S P + P S + GR A R +RR TP++ +
Sbjct: 459 SSPSRAKDRESPRSYSSTLT------DMGRSAPR----------ERRGTPEKEKLPA--- 499
Query: 1235 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 500 --KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 551
Score = 36.2 bits (82), Expect = 0.21
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
Score = 30.8 bits (68), Expect = 8.8
Identities = 61/284 (21%), Positives = 97/284 (34%), Gaps = 43/284 (15%)
Query: 222 SQPARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPDLTGA 266
S PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 223 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 282
Query: 267 VSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 326
D+ +E S ++ + P+T PT V + R+
Sbjct: 283 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT----PTPVPREPGRK------- 331
Query: 327 LSDPVSERRVGEQDSAPT----QEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVG 382
P+S R+GE +P+ PT +A ++ + QD S +E
Sbjct: 332 ---PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTRPPKKPLDYVQDHSSGVFNEAS 388
Query: 383 IPLRNTERSKD---WYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNP--- 436
+ + +RS + +M K + P P P + D P
Sbjct: 389 LYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP--PRGLGDQSASRTSPGRVDLPGSS 446
Query: 437 YTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
T T F +S+PS S D + SPR S T S PR +
Sbjct: 447 TTLTKSFTSSSPSSPSRAKDRE--SPRSYSSTLTDMGRSAPRER 488
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 277 bits (708), Expect = 5e-74
Identities = 209/615 (33%), Positives = 297/615 (48%), Gaps = 133/615 (21%)
Query: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 413 NPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKS 472
+ Y Y + S + +P T + P KS D+S + +D S
Sbjct: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY---RPLSKSHSDNSP------NAFKDASS 345
Query: 473 PLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP 532
P+ P P+P +SS+E++DW+PPD+KVDTRK+R+EP
Sbjct: 346 PVPPPHVPP-----------------PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 388
Query: 533 KSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDC 592
+SI+EY+PGKSS+ L+ +PPP P
Sbjct: 389 RSIFEYEPGKSSI----------------------------LQHERPPP------LPTTP 414
Query: 593 SILPREDRKTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGY 652
+ +PRE + L ++ + +PS P+S A PTP SS P
Sbjct: 415 TPVPREPGRKPLSSS-------------RLGEVTGSPSPP-PRSGA--PTP--SSRAPAL 456
Query: 653 IYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSE 712
S K+ D + + NE +Y+S ++ L+RP SSAS
Sbjct: 457 ---SPTRPPKKPLDYVQDHSSGVFNEASLYQSSID---------RSLERPMSSASM---- 500
Query: 713 SPRHFIPADYLESTEEFIRRRHDDKE----KLLADQRRLKREQEEADIAA------RRHT 762
+F +RR + + L DQ + D+ + T
Sbjct: 501 -------------ASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFT 547
Query: 763 GVIPTHHQFITNERF-----GDLLNIDDTAKRKSGS----EMRPARAKFDFKAQTLKELP 813
P+ + L ++ +A R+ E PA+A +DFKAQT KEL
Sbjct: 548 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELS 607
Query: 814 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEA 872
+KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEA
Sbjct: 608 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEA 667
Query: 873 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 932
IAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K
Sbjct: 668 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TK 726
Query: 933 NPVDYMDLPFSSSPS 947
DY D P S S
Sbjct: 727 GAEDYPDPPIPHSYS 741
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 770 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 53.1 bits (126), Expect = 2e-06
Identities = 74/296 (25%), Positives = 111/296 (37%), Gaps = 48/296 (16%)
Query: 996 PGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLAL 1055
PG+ S+ PPLP + P P S L ++ S P PRS A +
Sbjct: 396 PGKSSILQHERPPPLPTTPT----PVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSS 451
Query: 1056 PSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQS 1115
+P +L+PT ++ V SSG+ ++ L S+ L SS S
Sbjct: 452 RAP----ALSPTRPPKKPLDY---VQDHSSGVFNEASLY-----QSSIDRSLERPMSSAS 499
Query: 1116 KRQPWREESGQYERKAERGAGE-RGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEE 1174
+R+ RK+E G RG G S+ S P V S+ +
Sbjct: 500 MASDFRKR-----RKSEPAVGPPRGLGDQSASRTS---PGRVDLPGSSTTLTKSFTSSSP 551
Query: 1175 SRPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLF 1234
S P + P S + GR A R +RR TP++ +
Sbjct: 552 SSPSRAKDRESPRSYSSTLT------DMGRSAPR----------ERRGTPEKEKLPA--- 592
Query: 1235 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 593 --KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 644
Score = 31.2 bits (69), Expect = 6.7
Identities = 105/545 (19%), Positives = 189/545 (34%), Gaps = 116/545 (21%)
Query: 20 SNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMDPTKIC-TGKGAVTLRAS-- 76
++ QD ++ P+ S K+V+ S L P + P + T +++++ +
Sbjct: 69 THNQDLGSSSPISTPQFS-------KSVEVPSFLKRPRSLTPNPVPETHTASLSIQIAPL 121
Query: 77 -----SSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSS---SADANGNAQPSS 128
S+++ P SP + + Q E + S + + R+S + ++ G P S
Sbjct: 122 SGQDLESHKQLPELSPETAKIPLQQERQKSAVAAASQSSDCRVSQITVNGNSGGAVSPMS 181
Query: 129 LAAKGYRSVHPNLPSD-----------------------KSQDATSSSAAQPEVIVVPLY 165
+ + +LP+ +S D T+SS+ +PLY
Sbjct: 182 YYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSS-------IPLY 234
Query: 166 LVNTDRGQEGTARPP--TPLGPL--GCVPTIPATASAASPLTFPTL-------------- 207
+ + + + P +GP+ +PT T + T+
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 208 DDFIPPH-----LQRWPHHSQ--PARASGSFAPISQTPPSFSP---------------PP 245
D + P+ L P+ +Q PA + ++ P+S++ SP PP
Sbjct: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
Query: 246 PLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTT 305
P+ P P D + D D+ +E S ++ + P+T
Sbjct: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTT- 413
Query: 306 IVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPT----QEKPTSPGKAIEKRAKD 361
PT V + R+ P+S R+GE +P+ PT +A
Sbjct: 414 ---PTPVPREPGRK----------PLSSSRLGEVTGSPSPPPRSGAPTPSSRAPALSPTR 460
Query: 362 DSRRVVKSTQDLSDVSMDEVGIPLRNTERSKD---WYKTMFKQIHKLNRDTPEENPYFPT 418
++ + QD S +E + + +RS + +M K + P P P
Sbjct: 461 PPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGP--PR 518
Query: 419 YKFPELPEIQQTSEEDNP---YTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLS 475
+ D P T T F +S+PS S D + SPR S T S
Sbjct: 519 GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRE--SPRSYSSTLTDMGRS 576
Query: 476 VPRSK 480
PR +
Sbjct: 577 APRER 581
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 240 bits (612), Expect = 7e-63
Identities = 186/565 (32%), Positives = 255/565 (45%), Gaps = 162/565 (28%)
Query: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQF 443
PL+ +R KDWYKTMFKQIH +++ + + Y Y + S + +P T +
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
Query: 444 PASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPAR 503
P KS D+S + +D SP+ P P+P
Sbjct: 66 ---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP-----------------PVPPL 99
Query: 504 SSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLK 563
+SS+E++DW+PPD+KVDTR
Sbjct: 100 RPRDRSSTEKHDWDPPDRKVDTR------------------------------------- 122
Query: 564 NEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKME 623
KF SE P+ I++Y PG SIL E + SL Q+ ++ LE+
Sbjct: 123 -----KFRSE-------PRSIFEYEPGKSSILQHE-------RPASLYQSSIDRSLER-- 161
Query: 624 TLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 683
P SSA +S+F +R+S+ A G L ++
Sbjct: 162 ----------PMSSASM--------------ASDFRK-RRKSEPAVGPPRGLGDQSA--- 193
Query: 684 SVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLAD 743
S G + L G S S ++S+ S S R D+E
Sbjct: 194 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------RAKDRE----- 229
Query: 744 QRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFD 803
+ R ++ + + ER G E PA+A +D
Sbjct: 230 -------------SPRSYSSTLTDMGRSAPRERRGT-----------PEKEKLPAKAVYD 265
Query: 804 FKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP 863
FKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P
Sbjct: 266 FKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPP 325
Query: 864 -VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITY 922
Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++Y
Sbjct: 326 PAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSY 385
Query: 923 VDVIKRPLVKNPVDYMDLPFSSSPS 947
V+V+K+ K DY D P S S
Sbjct: 386 VEVVKKN-TKGAEDYPDPPIPHSYS 409
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 438 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 40.8 bits (94), Expect = 0.008
Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1181 LGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALY 1240
L +F S R + E ++ + ++RR TP++ + +A+Y
Sbjct: 210 LTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-----KAVY 264
Query: 1241 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+ Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 265 DFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 312
Score = 38.1 bits (87), Expect = 0.055
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 238 bits (607), Expect = 3e-62
Identities = 217/695 (31%), Positives = 294/695 (42%), Gaps = 194/695 (27%)
Query: 257 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 316
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
Query: 317 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 376
Q S S + D + P EKR V+K+
Sbjct: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Query: 377 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEE 433
+DE GIP +R T +R KDWYKTMFKQIH +++ PY S +
Sbjct: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNPPY---------------SAQ 207
Query: 434 DNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVK 493
+P T + P KS D+S + +D SP+ P
Sbjct: 208 SHPAAKTQTY---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP------------ 246
Query: 494 RSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSR 553
P+P +SS+E++DW+PPD+KVDTR
Sbjct: 247 -----PVPPLRPRDRSSTEKHDWDPPDRKVDTR--------------------------- 274
Query: 554 DISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQT 613
KF SE P+ I++Y PG SIL E + SL Q+
Sbjct: 275 ---------------KFRSE-------PRSIFEYEPGKSSILQHE-------RPASLYQS 305
Query: 614 ELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLT 673
++ LE+ P SSA +S+F +R+S+ A G
Sbjct: 306 SIDRSLER------------PMSSASM--------------ASDFRK-RRKSEPAVGPPR 338
Query: 674 SLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRR 733
L ++ S G + L G S S ++S+ S S R
Sbjct: 339 GLGDQSA---SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS-------------------R 376
Query: 734 HDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGS 793
D+E + R ++ + + ER G
Sbjct: 377 AKDRE------------------SPRSYSSTLTDMGRSAPRERRGT-----------PEK 407
Query: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 408 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 467
Query: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 468 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 527
Query: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 528 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 561
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 590 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 40.8 bits (94), Expect = 0.008
Identities = 27/110 (24%), Positives = 47/110 (42%), Gaps = 7/110 (6%)
Query: 1181 LGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALY 1240
L +F S R + E ++ + ++RR TP++ + +A+Y
Sbjct: 362 LTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA-----KAVY 416
Query: 1241 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+ Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 417 DFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 464
Score = 38.1 bits (87), Expect = 0.055
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 489 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
Score = 36.2 bits (82), Expect = 0.21
Identities = 22/44 (50%), Positives = 27/44 (61%), Gaps = 5/44 (11%)
Query: 106 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKS 146
P SA WR + + NG+A SSLAAKG+RSV PNL +S
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRS 68
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 199 bits (505), Expect = 2e-50
Identities = 97/155 (62%), Positives = 119/155 (76%), Gaps = 2/155 (1%)
Query: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 768 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 827
Query: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 828 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 887
Query: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 888 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 921
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 950 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 100 bits (249), Expect = 9e-21
Identities = 59/167 (35%), Positives = 86/167 (51%), Gaps = 41/167 (24%)
Query: 384 PLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYKFPELPEIQQTSEEDNPYTPTYQF 443
PL+ +R KDWYKTMFKQIH +++ PY S + +P T +
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPGLYNPPY---------------SAQSHPAAKTQTY 50
Query: 444 PASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPAR 503
P KS D+S + +D SP+ P P+P
Sbjct: 51 ---RPLSKSHSDNSP------NAFKDASSPVPPPHVPP-----------------PVPPL 84
Query: 504 SSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEK 550
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+
Sbjct: 85 RPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHER 131
Score = 73.6 bits (179), Expect = 1e-12
Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 29/159 (18%)
Query: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL- 850
E+ A AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++
Sbjct: 843 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 902
Query: 851 -----------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQV 884
PP + K Q T + GE A +N+ +
Sbjct: 903 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
Query: 885 EMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 963 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1001
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)
Query: 843 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 902
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 743 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 802
Query: 903 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 934
NWYEG G R GIFPI+YV+ + P P
Sbjct: 803 NWYEGEHHG--RVGIFPISYVEKLTPPEKAQP 832
Score = 42.4 bits (98), Expect = 0.003
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)
Query: 1180 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1231
P ++F + + H RGG R++ R S + ++RR TP++ +
Sbjct: 713 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 772
Query: 1232 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 773 -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 824
Score = 38.1 bits (87), Expect = 0.055
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 849 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 199 bits (505), Expect = 2e-50
Identities = 97/155 (62%), Positives = 119/155 (76%), Gaps = 2/155 (1%)
Query: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPA 853
E PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P
Sbjct: 864 EKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPP 923
Query: 854 EKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT
Sbjct: 924 EKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGT 983
Query: 913 SRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPS 947
+RQGIFP++YV+V+K+ K DY D P S S
Sbjct: 984 NRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYS 1017
Score = 106 bits (265), Expect = 1e-22
Identities = 68/198 (34%), Positives = 105/198 (53%), Gaps = 31/198 (15%)
Query: 358 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDTPEE 412
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ +
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 413 NPYFPTYKFPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKS 472
+ Y Y + S + +P T + P KS D+S + +D S
Sbjct: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY---RPLSKSHSDNSP------NAFKDASS 166
Query: 473 PLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP 532
P+ P P+P +SS+E++DW+PPD+KVDTRK+R+EP
Sbjct: 167 PVPPPH-----------------VPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEP 209
Query: 533 KSIYEYQPGKSSVLTNEK 550
+SI+EY+PGKSS+L +E+
Sbjct: 210 RSIFEYEPGKSSILQHER 227
Score = 102 bits (254), Expect = 2e-21
Identities = 44/55 (80%), Positives = 51/55 (92%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1046 FQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 73.6 bits (179), Expect = 1e-12
Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 29/159 (18%)
Query: 794 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL- 850
E+ A AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++
Sbjct: 939 EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVK 998
Query: 851 -----------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQV 884
PP + K Q T + GE A +N+ +
Sbjct: 999 KNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 1058
Query: 885 EMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 1059 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 1097
Score = 65.9 bits (159), Expect = 2e-10
Identities = 34/92 (36%), Positives = 52/92 (56%), Gaps = 2/92 (2%)
Query: 843 PRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 902
PR+Y L ++ P++ E A A ++F T E+SF+KG+ + +LR++D+
Sbjct: 839 PRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQ 898
Query: 903 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 934
NWYEG G R GIFPI+YV+ + P P
Sbjct: 899 NWYEGEHHG--RVGIFPISYVEKLTPPEKAQP 928
Score = 42.4 bits (98), Expect = 0.003
Identities = 31/119 (26%), Positives = 53/119 (44%), Gaps = 15/119 (12%)
Query: 1180 PLGSAFPGSEAEQTERH---RGGEQAGRKAARRGGSQ-----QPQAQQRRVTPDRSQTSQ 1231
P ++F + + H RGG R++ R S + ++RR TP++ +
Sbjct: 809 PRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPA 868
Query: 1232 DLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+A+Y + Q EL + GD V ++ K D W+ G + G FP +YV+ L
Sbjct: 869 -----KAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEG--EHHGRVGIFPISYVEKL 920
Score = 38.1 bits (87), Expect = 0.055
Identities = 18/51 (35%), Positives = 29/51 (56%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A Y++ + EL LR GD V ++++ D W+ G T + G FP +YV+
Sbjct: 945 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVE 995
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 198 bits (503), Expect = 3e-50
Identities = 113/247 (45%), Positives = 146/247 (59%), Gaps = 20/247 (8%)
Query: 789 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 848
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435
Query: 849 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
Query: 909 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968
I GT RQGIFP +YV V + P ++ D LP S + +A ++ SS S L +PA
Sbjct: 496 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPA-- 553
Query: 969 SLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRAS 1028
+ I L RR+ P P P+ T ALS
Sbjct: 554 ------------------DPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRG 595
Query: 1029 PSLSLSL 1035
PS L L
Sbjct: 596 PSHPLDL 602
Score = 99.0 bits (245), Expect = 3e-20
Identities = 46/80 (57%), Positives = 56/80 (70%), Gaps = 11/80 (13%)
Query: 1211 GSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 1270
G+ P Q TP Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFV
Sbjct: 603 GTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFV 651
Query: 1271 GTSRRTKQFGTFPGNYVKPL 1290
G SRRT++FGTFPGNYV P+
Sbjct: 652 GVSRRTQKFGTFPGNYVAPV 671
Score = 75.1 bits (183), Expect = 4e-13
Identities = 96/377 (25%), Positives = 157/377 (41%), Gaps = 65/377 (17%)
Query: 493 KRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMS 552
+R A P PA SSS +S W+ ++ P+S + Y+PG S +
Sbjct: 181 QRPAHRPGPATSSSGRS------WDHSEEL---------PRSTFNYRPGAFSTVLQPSNQ 225
Query: 553 RDISPEEID--LKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSL 610
E++D E W +F ELE G+ P K + D PG+ P + + L+++L+
Sbjct: 226 VLRRREKVDNVWTEESWNQFLQELETGQRPKKPLVD-DPGE---KPSQPIEVLLERELAE 281
Query: 611 CQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNF-HAVKRESDGAP 669
EL+ DL +ET +P ++ A P P +SS++ HA
Sbjct: 282 LSAELDKDLRAIETRLPSPKSSPAPRRAPEQRPPAG---PASAWSSSYPHA--------- 329
Query: 670 GDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKD-SESPRHFIPADYLESTEE 728
L + R + + G P G PS ST+D S S PA E +
Sbjct: 330 ---PYLGSARSLSPHKMADGGSPFLGRRDFVYPS---STRDPSASNGGGSPARREEKKRK 383
Query: 729 FIRRRHD-----DKEKLL--ADQRRLKREQEEADIAARRH--TGVIPTHHQFITNERFGD 779
R + D KE L D + +E ++ + H G+ P + + +
Sbjct: 384 AARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPAN--------YVE 435
Query: 780 LLNIDDTAK-----RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE 834
+L D+ K E A A++ FK EL +KG+ + + +++++NWYEG
Sbjct: 436 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 495
Query: 835 --HHGRVGIFPRTYIEL 849
GR GIFP +Y+++
Sbjct: 496 ITGTGRQGIFPASYVQV 512
Score = 38.9 bits (89), Expect = 0.032
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 838
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 600 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 659
Query: 839 VGIFPRTYI 847
G FP Y+
Sbjct: 660 FGTFPGNYV 668
Score = 38.5 bits (88), Expect = 0.042
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 874 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
A + + + E+ R+G+R+ +++Q D+ W+ G T + G FP YV
Sbjct: 619 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 38.1 bits (87), Expect = 0.055
Identities = 35/120 (29%), Positives = 54/120 (45%), Gaps = 30/120 (25%)
Query: 360 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDTPEENPYF 416
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHR------------ 156
Query: 417 PTYKFPELPEIQQTSEE---DNPYTPTYQFPASTPSP------KSEDDDSDLYSPRYSFS 467
K P+L ++ T EE D + Q PA P P +S D +L PR +F+
Sbjct: 157 ---KMPDL-QLDWTFEEPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEEL--PRSTFN 210
Score = 36.6 bits (83), Expect = 0.16
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 1206 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1265
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 367 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 414
Query: 1266 DGWFVGTSRRTKQFGTFPGNYVKPL 1290
W G + G FP NYV+ L
Sbjct: 415 KNWLEG--EHHGRLGIFPANYVEVL 437
Score = 35.4 bits (80), Expect = 0.36
Identities = 70/268 (26%), Positives = 103/268 (38%), Gaps = 58/268 (21%)
Query: 1024 SPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNGDGGVHTP 1083
SP++SP+ P + RP P AS + PH Y L S H DGG +P
Sbjct: 299 SPKSSPA-----PRRAPEQRP-PAGPASAWSSSYPHAPY-LGSARSLSPHKMADGG--SP 349
Query: 1084 SSGIHQDSFLQLPLGSSDSVI-SQLSDAFSSQSKRQPWREESGQYERKAERGAGERGPGG 1142
LG D V S D +S P R E + +RKA R +
Sbjct: 350 F------------LGRRDFVYPSSTRDPSASNGGGSPARRE--EKKRKAARLKFDFQAQS 395
Query: 1143 PKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGEQA 1202
PK + L+ D+V + D N E G+ LG FP + E
Sbjct: 396 PK---ELTLQKGDIVYI----HKEVDKNWLEGEHHGR-LG-IFPANYVEVLP-------- 438
Query: 1203 GRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL--RDGDIVDV 1260
+ P+ P + T Q L +A+ Y + D E+EL R G+ + +
Sbjct: 439 --------ADEIPK-------PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICL 483
Query: 1261 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
+ K ++ W+ G T + G FP +YV+
Sbjct: 484 IRKVNENWYEGRITGTGRQGIFPASYVQ 511
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 198 bits (503), Expect = 3e-50
Identities = 113/247 (45%), Positives = 146/247 (59%), Gaps = 20/247 (8%)
Query: 789 RKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 848
R+ + + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 849 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 909 IPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968
I GT RQGIFP +YV V + P ++ D LP S + +A ++ SS S L +PA
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPA-- 211
Query: 969 SLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRAS 1028
+ I L RR+ P P P+ T ALS
Sbjct: 212 ------------------DPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRG 253
Query: 1029 PSLSLSL 1035
PS L L
Sbjct: 254 PSHPLDL 260
Score = 99.0 bits (245), Expect = 3e-20
Identities = 46/80 (57%), Positives = 56/80 (70%), Gaps = 11/80 (13%)
Query: 1211 GSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 1270
G+ P Q TP Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFV
Sbjct: 261 GTSSPNTSQIHWTP-----------YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFV 309
Query: 1271 GTSRRTKQFGTFPGNYVKPL 1290
G SRRT++FGTFPGNYV P+
Sbjct: 310 GVSRRTQKFGTFPGNYVAPV 329
Score = 38.9 bits (89), Expect = 0.032
Identities = 20/69 (28%), Positives = 34/69 (49%), Gaps = 2/69 (2%)
Query: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGR 838
L++ ++ S P RA + ++ Q EL L++GD V + +Q D W+ G +
Sbjct: 258 LDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQK 317
Query: 839 VGIFPRTYI 847
G FP Y+
Sbjct: 318 FGTFPGNYV 326
Score = 38.5 bits (88), Expect = 0.042
Identities = 15/50 (30%), Positives = 28/50 (56%)
Query: 874 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 923
A + + + E+ R+G+R+ +++Q D+ W+ G T + G FP YV
Sbjct: 277 AMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 36.6 bits (83), Expect = 0.16
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 14/85 (16%)
Query: 1206 AARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 1265
A+ GGS + +++R + ++ F +QA Q+ EL L+ GDIV + ++ D
Sbjct: 25 ASNGGGSPARREEKKR------KAARLKFDFQA------QSPKELTLQKGDIVYIHKEVD 72
Query: 1266 DGWFVGTSRRTKQFGTFPGNYVKPL 1290
W G + G FP NYV+ L
Sbjct: 73 KNWLEG--EHHGRLGIFPANYVEVL 95
Score = 35.0 bits (79), Expect = 0.46
Identities = 21/67 (31%), Positives = 36/67 (53%), Gaps = 2/67 (2%)
Query: 1224 PDRSQTSQDLFSYQALYSYIPQNDDELEL--RDGDIVDVMEKCDDGWFVGTSRRTKQFGT 1281
P + T Q L +A+ Y + D E+EL R G+ + ++ K ++ W+ G T + G
Sbjct: 103 PIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGI 162
Query: 1282 FPGNYVK 1288
FP +YV+
Sbjct: 163 FPASYVQ 169
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 87.8 bits (216), Expect = 6e-17
Identities = 52/172 (30%), Positives = 89/172 (51%), Gaps = 17/172 (9%)
Query: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 858
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 859 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 916
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
Query: 917 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPS 968
IFP+ YV++ K ++ MD P ++ S + P S + P+P+
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAASSCNASLPSDSGAVASVAPSPT 356
Score = 82.4 bits (202), Expect = 3e-15
Identities = 111/486 (22%), Positives = 184/486 (37%), Gaps = 98/486 (20%)
Query: 850 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 908
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 909 IPGTSRQGIFPITYVDVIKR-----------------PLVKNPVDYMDLPFSSSPSRSAT 951
T G+FP YV + R PL K M P S S S AT
Sbjct: 506 SLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMH-PGSGSLSSLAT 564
Query: 952 AS--------PQ-FSSHSKLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGVPGRRSLA 1002
A+ PQ + H P S L HS + + + + S R +
Sbjct: 565 ATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTAT 624
Query: 1003 LTPPLPP-----LPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPS 1057
++P LP S+ H +SP+ S P + RP A+P
Sbjct: 625 VSPLRTQNSPSRLPATSL--RPHSVVSPQHSHQ-----PPVQMCPRP---------AIPL 668
Query: 1058 PHKTYSLAPTSQASLHMNGDGG--------VHTPSS-GIHQDSFLQLPLGSSDSVISQLS 1108
++ P + ++ ++NG+ G +P++ G D ++ L+
Sbjct: 669 TSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLA 728
Query: 1109 DAFSSQSKRQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSD 1168
A + + R P S ++ + A +G GP++S S
Sbjct: 729 GASTKKKSRSP-PSVSPTHDPQVAVDALLQGAVGPEVSSLSI------------------ 769
Query: 1169 LNTPEESRPGK-PLGSAFPGSEAEQTERHRGGEQAGRKAAR-----RGGSQQPQAQQRRV 1222
R G P+ S G+ G E RKA S+Q +
Sbjct: 770 -----HGRAGSCPIESEMQGA--------MGMEPLHRKAGSLDLNFTSPSRQAPLSMAAI 816
Query: 1223 TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTF 1282
P+ ++ Y+ + SY PQ++ E+EL++GDIV V +K +DGW+ GT +R + G F
Sbjct: 817 RPEPKLLPRE--RYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLF 874
Query: 1283 PGNYVK 1288
PG++V+
Sbjct: 875 PGSFVE 880
Score = 73.9 bits (180), Expect = 9e-13
Identities = 36/68 (52%), Positives = 44/68 (64%), Gaps = 2/68 (2%)
Query: 1223 TPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTF 1282
TP + Q ++ Y ALY+Y PQ DELEL G++ V+EKC DGWF G S RT G F
Sbjct: 458 TPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVF 515
Query: 1283 PGNYVKPL 1290
PGNYV P+
Sbjct: 516 PGNYVTPV 523
Score = 45.8 bits (107), Expect = 3e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 848
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 40.8 bits (94), Expect = 0.008
Identities = 36/129 (27%), Positives = 54/129 (41%), Gaps = 20/129 (15%)
Query: 1171 TPEESRPGKPLGSAFPGSEAEQTERHRGGEQAGRK----------AARRGGSQQPQAQQR 1220
+P S P +P+ PG A T GG AG A GS + A R
Sbjct: 130 SPGGSPPARPI----PGQSAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSR 185
Query: 1221 RVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQF 1279
++ L Y +ALYSY + +L+ GDI+ + K D+ W+ G T+
Sbjct: 186 TAPAAKNPC---LLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ-- 240
Query: 1280 GTFPGNYVK 1288
G P +Y++
Sbjct: 241 GFLPASYIQ 249
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 86.3 bits (212), Expect = 2e-16
Identities = 108/465 (23%), Positives = 180/465 (38%), Gaps = 78/465 (16%)
Query: 873 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 932
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 933 NPVDYMDLPFSSSPSRSAT-------ASPQFSSHSKLITPAPSSLPHSRRALSPEMHAVT 985
+ + + SR T P + +PS +P A+ H T
Sbjct: 511 ASQAKVPMSTAGQTSRGVTMVSPSTAGGPAQKLQGNGVAGSPSVVP---AAVVSAAHIQT 567
Query: 986 SEWISLTVGVPG--------------------RRSLALTP----PLPPLPEASIYNTDHL 1021
S + + + G R + A+TP L AS+ + H
Sbjct: 568 SPQAKVLLHMTGQMTVNQARNAVRTVAAHNQERPTAAVTPIQVQNAAGLSPASVGLSHHS 627
Query: 1022 ALSPRASPSLSLSLPH-----LSWSDRPTPRSVASPLALPSPHKTYSLAPTSQASLHMNG 1076
SP+ +P + S H +S + P + A+PL PS + ASL
Sbjct: 628 LASPQPAPLMPGSATHTAAISISRASAPLACAAAAPLTSPS---------ITSASLEAEP 678
Query: 1077 DGGVHTPSSGIHQDSFLQLPLGSSDSVISQLSDAFSSQSKRQPWREESGQYERKAERGAG 1136
G + T G+ S DS S ++ +++ + +E+ G K GA
Sbjct: 679 SGRIVTVLPGLPT---------SPDSASSACGNSSATKPDKDSKKEKKGLL--KLLSGAS 727
Query: 1137 ERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPE------ESRPGK-------PLGS 1183
+ P++S + P+ V S E L PE R G P+ +
Sbjct: 728 TKRK--PRVSPPA--SPTLEVELGSAELPLQGAVGPELPPGGGHGRAGSCPVDGDGPVTT 783
Query: 1184 AFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYI 1243
A G+ Q HR +Q + V + + ++ + SY
Sbjct: 784 AVAGAALAQDAFHRKASSLDSAVPIAPPPRQACSSLGPVLNESRPVVCE--RHRVVVSYP 841
Query: 1244 PQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 842 PQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 84.0 bits (206), Expect = 9e-16
Identities = 79/310 (25%), Positives = 135/310 (43%), Gaps = 46/310 (14%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 858 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 913
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 914 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQFSSHSK------- 961
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ S K
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHS 304
Query: 962 --LITPAPSSLPHSRR-------------ALSPEMHAVTSEWISLTVGVPGRRSLALTPP 1006
+T A S S+ + +P A SE L+ P + ++ T
Sbjct: 305 FTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGL 364
Query: 1007 LPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRPTPRSVASPLALPSPHKTYSLAP 1066
+ P +S T P P +L L+ P P A+ LA P T + A
Sbjct: 365 IVTPPPSSPVTTGPSFTFPSDVP-YQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAA 423
Query: 1067 TSQASLHMNG 1076
M G
Sbjct: 424 AGMGPRPMAG 433
Score = 78.2 bits (191), Expect = 5e-14
Identities = 56/155 (36%), Positives = 71/155 (45%), Gaps = 24/155 (15%)
Query: 1140 PGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTPEESRP---GKPLGSAFPGSEAEQTERH 1196
P P + S PSDV + L LN P P L S PG+ A
Sbjct: 370 PSSPVTTGPSFTFPSDV----PYQAALGTLNPPLPPPPLLAATVLASTPPGATAA----- 420
Query: 1197 RGGEQAGRKAARRGGSQQPQAQQR-RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 1255
AA G +P A ++ R QT + Y A+Y Y P+ +DELELR G
Sbjct: 421 ---------AAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRKEDELELRKG 469
Query: 1256 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 470 EMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 45.4 bits (106), Expect = 3e-04
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 51/255 (20%)
Query: 609 SLCQTELEAD--------LEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
S+ LEA+ L + T + S+ SSA P + E G + + +
Sbjct: 668 SITSASLEAEPSGRIVTVLPGLPTSPDSASSACGNSSATKPDKDSKKEKKGLLKLLSGAS 727
Query: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
KR+ +P +LE E L ++PLQG G + P + P +
Sbjct: 728 TKRKPRVSPPASPTLEVE-------LGSAELPLQGAVGPELPPGGGHGRAGSCP---VDG 777
Query: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
D +T Q R+ D A + P Q ++ G +
Sbjct: 778 DGPVTTAV---------AGAALAQDAFHRKASSLDSAVP----IAPPPRQACSS--LGPV 822
Query: 781 LNIDDTAKRKSGSEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG-- 833
LN E RP R + Q+ EL L++GDIV+++K+ + W++G
Sbjct: 823 LN-----------ESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTL 871
Query: 834 EHHGRVGIFPRTYIE 848
+ +G+ G+FP +++E
Sbjct: 872 QRNGKTGLFPGSFVE 886
Score = 35.4 bits (80), Expect = 0.36
Identities = 32/118 (27%), Positives = 51/118 (43%), Gaps = 8/118 (6%)
Query: 1176 RPGKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFS 1235
+PG GS + A +++ + + G QQP+ Q P R L
Sbjct: 82 KPGPGGGSGTNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWS-PPVRG--IPQLPC 138
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 1290
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 6.7
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 882 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 84.0 bits (206), Expect = 9e-16
Identities = 41/127 (32%), Positives = 73/127 (57%), Gaps = 4/127 (3%)
Query: 803 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 860
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 446 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 505
Query: 861 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 920
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 506 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 563
Query: 921 TYVDVIK 927
+V+ ++
Sbjct: 564 NFVEPVE 570
Score = 77.8 bits (190), Expect = 6e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 786 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 838
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 588 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 647
Query: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 648 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 702
Query: 899 QVDENWYEGRIPGTSRQGIFPITYVDVIK 927
VD++W G + G S GIFP Y+ ++
Sbjct: 703 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 729
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 31/207 (14%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 851
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
Query: 852 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 903
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
Query: 904 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLI 963
W GR+ R+GIFP +V RP P + + R A A F ++
Sbjct: 639 WCRGRL--QDREGIFPAVFV----RPC---PAEAKSMLAIVPKGRKAKALYDFRGENE-- 687
Query: 964 TPAPSSLPHSRRALSPEMHAVTSEWIS 990
L + E+ +V +W+S
Sbjct: 688 ----DELSFKAGDIITELESVDDDWMS 710
Score = 49.7 bits (117), Expect = 2e-05
Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 15/130 (11%)
Query: 1172 PEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGRKAARRGGSQQPQAQQRRVT 1223
P +PG PL S + + +QTE + + GE GR + P + R
Sbjct: 364 PPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSR 423
Query: 1224 PDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 1278
P+ +Q A L+ + + D+L L G+IV ++EK D W+ G R Q
Sbjct: 424 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQ 481
Query: 1279 FGTFPGNYVK 1288
G FP NYVK
Sbjct: 482 IGIFPANYVK 491
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 816 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 870
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 871 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 493
Score = 43.9 bits (102), Expect = 0.001
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 730
Score = 35.4 bits (80), Expect = 0.36
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 84.0 bits (206), Expect = 9e-16
Identities = 41/127 (32%), Positives = 73/127 (57%), Gaps = 4/127 (3%)
Query: 803 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 860
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 482 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 541
Query: 861 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 920
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 542 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 599
Query: 921 TYVDVIK 927
+V+ ++
Sbjct: 600 NFVEPVE 606
Score = 77.8 bits (190), Expect = 6e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 786 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 838
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 624 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 683
Query: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 684 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 738
Query: 899 QVDENWYEGRIPGTSRQGIFPITYVDVIK 927
VD++W G + G S GIFP Y+ ++
Sbjct: 739 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 765
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 31/207 (14%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 851
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 614
Query: 852 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 903
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 615 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 674
Query: 904 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLI 963
W GR+ R+GIFP +V RP P + + R A A F ++
Sbjct: 675 WCRGRL--QDREGIFPAVFV----RPC---PAEAKSMLAIVPKGRKAKALYDFRGENE-- 723
Query: 964 TPAPSSLPHSRRALSPEMHAVTSEWIS 990
L + E+ +V +W+S
Sbjct: 724 ----DELSFKAGDIITELESVDDDWMS 746
Score = 49.7 bits (117), Expect = 2e-05
Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 15/130 (11%)
Query: 1172 PEESRPGKPLGSAFPGSEA----EQTERH----RGGEQAGRKAARRGGSQQPQAQQRRVT 1223
P +PG PL S + + +QTE + + GE GR + P + R
Sbjct: 400 PPRPKPGHPLYSKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSR 459
Query: 1224 PDRSQTSQDLFSYQA-----LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 1278
P+ +Q A L+ + + D+L L G+IV ++EK D W+ G R Q
Sbjct: 460 PNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQ 517
Query: 1279 FGTFPGNYVK 1288
G FP NYVK
Sbjct: 518 IGIFPANYVK 527
Score = 48.9 bits (115), Expect = 3e-05
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 8/117 (6%)
Query: 816 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 870
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 415 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 474
Query: 871 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 926
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 475 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI 529
Score = 43.9 bits (102), Expect = 0.001
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
Score = 35.4 bits (80), Expect = 0.36
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 605
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 84.0 bits (206), Expect = 9e-16
Identities = 41/127 (32%), Positives = 73/127 (57%), Gaps = 4/127 (3%)
Query: 803 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKK 860
DF A+ + +L L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++
Sbjct: 505 DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRE 564
Query: 861 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 920
++ +A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+
Sbjct: 565 CVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPL 622
Query: 921 TYVDVIK 927
+V+ ++
Sbjct: 623 NFVEPVE 629
Score = 77.8 bits (190), Expect = 6e-14
Identities = 49/149 (32%), Positives = 79/149 (53%), Gaps = 14/149 (9%)
Query: 786 TAKRKSGSEMR----PAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR 838
T K SGS + PA A F A+T +L ++GD + I +++D +W G R
Sbjct: 647 TKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR 706
Query: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
GIFP ++ P A+ K + + V + +A A ++F G+ + E+SF+ G+ IT L
Sbjct: 707 EGIFPAVFVRPCP----AEAKSMLAI-VPKGRKAKALYDFRGENEDELSFKAGDIITELE 761
Query: 899 QVDENWYEGRIPGTSRQGIFPITYVDVIK 927
VD++W G + G S GIFP Y+ ++
Sbjct: 762 SVDDDWMSGELMGKS--GIFPKNYIQFLQ 788
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 31/207 (14%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 851
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 852 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 903
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
Query: 904 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLI 963
W GR+ R+GIFP +V RP P + + R A A F ++
Sbjct: 698 WCRGRL--QDREGIFPAVFV----RPC---PAEAKSMLAIVPKGRKAKALYDFRGENE-- 746
Query: 964 TPAPSSLPHSRRALSPEMHAVTSEWIS 990
L + E+ +V +W+S
Sbjct: 747 ----DELSFKAGDIITELESVDDDWMS 769
Score = 54.3 bits (129), Expect = 7e-07
Identities = 39/133 (29%), Positives = 66/133 (49%), Gaps = 8/133 (6%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKA 856
A D +Q EL ++GD++ + KQ + N+ E GE GRV + I L ++
Sbjct: 422 ANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRS 481
Query: 857 QPKKLTPVQV-LEYG--EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTS 913
+P + Q ++ G A+ +F + +++ GE + LL ++D +WY G +
Sbjct: 482 RPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RN 539
Query: 914 RQGIFPITYVDVI 926
+ GIFP YV VI
Sbjct: 540 QIGIFPANYVKVI 552
Score = 43.9 bits (102), Expect = 0.001
Identities = 21/56 (37%), Positives = 32/56 (57%), Gaps = 2/56 (3%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1292
+ALY + +N+DEL + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 789
Score = 43.5 bits (101), Expect = 0.001
Identities = 21/50 (42%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 1239 LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
L+ + + D+L L G+IV ++EK D W+ G R Q G FP NYVK
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCR--NQIGIFPANYVK 550
Score = 35.4 bits (80), Expect = 0.36
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 2/53 (3%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
A + YI + DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 628
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/224 (26%), Positives = 110/224 (49%), Gaps = 26/224 (11%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 858 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 913
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
Query: 914 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPA 966
+ GIFPI +V+ ++++ + +L SS SR T++ + S+ P
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
Query: 967 PSSLPHSRRALSPEMHAVTSEW---ISLTVGVPGRRSLALTPPL 1007
S+ + L+ +H+ + IS V + +T P+
Sbjct: 298 QFSITTALNTLNRMVHSPSGRHMVEISTPVLISSSNPSVITQPM 341
Score = 56.6 bits (135), Expect = 1e-07
Identities = 26/56 (46%), Positives = 35/56 (62%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 1291
+ AL+SY DEL+L+ G+ V V+ KC DGW G S T + G FP NYV P++
Sbjct: 385 FVALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
Score = 35.0 bits (79), Expect = 0.46
Identities = 25/88 (28%), Positives = 41/88 (46%), Gaps = 4/88 (4%)
Query: 1201 QAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 1260
Q GRK+ R ++ QA R+ P+ + +AL +Y QN +L GDI+ +
Sbjct: 97 QDGRKS--RTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILL 154
Query: 1261 MEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
+ D+ W+ G G FP + V+
Sbjct: 155 RRQLDENWYQGEINGIS--GNFPASSVE 180
Score = 33.9 bits (76), Expect = 1.0
Identities = 18/56 (32%), Positives = 28/56 (50%)
Query: 873 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 928
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFR 441
Score = 33.9 bits (76), Expect = 1.0
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH--HGRVGIFPRTYI 847
A + A EL LQKG+ V + + W G GRVGIFP Y+
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYV 436
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 73.9 bits (180), Expect = 9e-13
Identities = 86/357 (24%), Positives = 148/357 (41%), Gaps = 63/357 (17%)
Query: 796 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---PP 852
R + F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP ++ELL PP
Sbjct: 86 RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145
Query: 853 A-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFNGDTQVEMSFRKG 891
+ +P KL+ +Q + + E F++ + E++ R+G
Sbjct: 146 SLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRG 205
Query: 892 ERITLLRQV--DENWYEGRIPGTSRQGIFPITYV---DVIKRPLVKNPVDYMDLPFSSSP 946
+ + +L + D+ W+EG G R+G+FP +V IK+ + + V P
Sbjct: 206 DVVKVLSKTTEDKGWWEGECQG--RRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIKEPK 263
Query: 947 SRSATASPQFSSHSKLITPAPSSLPHSRRALSPEMHAVTSEWISLTVGV-------PGR- 998
S T PS SR S + +TS G PGR
Sbjct: 264 KLMPKTSLPTVKKLATATTGPSKAKTSRTP-SRDSQKLTSRDSGPNGGFQSGGSYHPGRK 322
Query: 999 RSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLS-LPHLSWS--------DRPTPRSV 1049
RS TP + S+ + + SP +PS+ + +P + + + P+ + +
Sbjct: 323 RSKTQTP-----QQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKI 377
Query: 1050 ASPLALPSPHKTYSLAPTSQASLHMNGDGG-------VHTPSSGIHQDSFLQLPLGS 1099
+P +PSP KT +L +AS+ N G V TP + + +P S
Sbjct: 378 PAPDKVPSPEKTLTLG--DKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENS 432
Score = 55.1 bits (131), Expect = 4e-07
Identities = 46/199 (23%), Positives = 89/199 (44%), Gaps = 29/199 (14%)
Query: 804 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 862
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 863 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 912
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 913 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQFSSHSKLITPAPSSL 970
+ G FP +V+++ P + NP D+P + SP KL + A S
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP---------SVSPGPQRPPKLSSLAYDSP 173
Query: 971 PHSRRALS-PEMHAVTSEW 988
P + +S PE++ V ++
Sbjct: 174 PDYLQTVSHPEVYRVLFDY 192
Score = 53.9 bits (128), Expect = 1e-06
Identities = 27/81 (33%), Positives = 50/81 (61%), Gaps = 4/81 (4%)
Query: 1210 GGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWF 1269
G +++P+ +RR P + Q +SY P+ DEL+L+ G+IV+++++ +DGW+
Sbjct: 64 GEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQADELKLQAGEIVEMIKEIEDGWW 121
Query: 1270 VGTSRRTKQFGTFPGNYVKPL 1290
+G ++ Q G FP N+V+ L
Sbjct: 122 LG--KKNGQLGAFPSNFVELL 140
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/68 (41%), Positives = 37/68 (54%), Gaps = 4/68 (5%)
Query: 1224 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGT 1281
PD QT Y+ L+ Y P+ DEL LR GD+V V+ K D GW+ G + + G
Sbjct: 174 PDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GV 231
Query: 1282 FPGNYVKP 1289
FP N+V P
Sbjct: 232 FPDNFVLP 239
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 795 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 854
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
Query: 855 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 890
TPV E G +A + F E+ F
Sbjct: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 891 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 948
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
Score = 43.5 bits (101), Expect = 0.001
Identities = 31/125 (24%), Positives = 53/125 (42%), Gaps = 11/125 (8%)
Query: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 858
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
Query: 859 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 918
++L + F + +G+ + L W +GR +R G F
Sbjct: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
Query: 919 PITYV 923
P + V
Sbjct: 117 PSSCV 121
Score = 36.2 bits (82), Expect = 0.21
Identities = 16/52 (30%), Positives = 31/52 (59%), Gaps = 2/52 (3%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
+A++ + P +EL L GDI++V+ D+ W +G ++ G FP ++V+
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLG--KKEDVTGQFPSSFVE 57
Score = 36.2 bits (82), Expect = 0.21
Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
Score = 33.9 bits (76), Expect = 1.0
Identities = 18/70 (25%), Positives = 33/70 (47%), Gaps = 3/70 (4%)
Query: 1219 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 1278
+ + PD + + ALY + +EL+ GD + ++ +DGW G+ + +
Sbjct: 232 EEEIGPDEDEEEPGTYGV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GR 288
Query: 1279 FGTFPGNYVK 1288
G FP +VK
Sbjct: 289 TGIFPYRFVK 298
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 786 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 838
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
Query: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1077 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1131
Query: 899 QVDENWYEGRIPGTSRQGIFPITYV 923
+ D +W++G I G + G+FP YV
Sbjct: 1132 KDDPDWWQGEINGVT--GLFPSNYV 1154
Score = 62.0 bits (149), Expect = 4e-09
Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 14/136 (10%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 854
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 876 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 934
Query: 855 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 907
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 935 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 993
Query: 908 RIPGTSRQGIFPITYV 923
I R GIFP YV
Sbjct: 994 SI--GDRSGIFPSNYV 1007
Score = 50.1 bits (118), Expect = 1e-05
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 19/139 (13%)
Query: 727 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 786
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 678 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 724
Query: 787 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 844
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 725 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 783
Query: 845 TYIELLPPAEK---AQPKK 860
Y+E +P +E PKK
Sbjct: 784 NYVEKMPSSENEKAVSPKK 802
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 1200 EQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 1259
++ RKA + Q+ + + +T+ L +Y+ALY + +N DE+ GDI+
Sbjct: 702 QEEERKAEEK---QRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQ 758
Query: 1260 VMEKC--DDGWFVGTSRRTKQFGTFPGNYVKPL 1290
V EK + GW G+ + FG FP NYV+ +
Sbjct: 759 VDEKTVGEPGWLYGSFQ--GNFGWFPCNYVEKM 789
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1164
Score = 44.3 bits (103), Expect = 8e-04
Identities = 21/51 (41%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A+Y Y N+DEL G +++VM K D W+ G G FP NYVK
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1155
Score = 39.3 bits (90), Expect = 0.025
Identities = 32/127 (25%), Positives = 56/127 (44%), Gaps = 20/127 (15%)
Query: 814 LQKGDIVY------IYKQIDQNWYEGEHHGRVGIFPRTYI-----ELLPPAEKAQPKKLT 862
++ GD+ + + Q D W+ G R GIFP Y+ E A K+
Sbjct: 968 VEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKK 1027
Query: 863 PVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFP 919
P E + + + +G Q +S G+ I +L++ W++G + G RQ G FP
Sbjct: 1028 P----EIAQVTSAYVASGSEQ--LSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFP 1081
Query: 920 ITYVDVI 926
++V ++
Sbjct: 1082 ASHVKLL 1088
Score = 34.3 bits (77), Expect = 0.79
Identities = 16/57 (28%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1290
Q +Y+ ++L L G ++ +++K GW+ G + + +Q G FP ++VK L
Sbjct: 1032 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1088
Score = 33.9 bits (76), Expect = 1.0
Identities = 38/125 (30%), Positives = 53/125 (42%), Gaps = 11/125 (8%)
Query: 986 SEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHL-SWSDRP 1044
S IS G+ +L++ PLPP + ++ A S P L + P + S S
Sbjct: 110 SPLISARFGMGSMPNLSIPQPLPPAAPITSLSS---ATSGTNLPPLMMPTPLVPSVSTSS 166
Query: 1045 TPRSVASPLA-LPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSV 1103
P AS + LP P+ + +L S SL M G GG Q + + LGSS S
Sbjct: 167 LPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASI------QKAQSLIDLGSSSST 220
Query: 1104 ISQLS 1108
S S
Sbjct: 221 SSTAS 225
Score = 33.9 bits (76), Expect = 1.0
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 1289
Y ALY Y +L +G+ + V +K + W R+ G FP NYVKP
Sbjct: 959 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1009
Score = 31.6 bits (70), Expect = 5.1
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 7/54 (12%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWF--VGTSRRTKQFGTFPGNYVK 1288
QAL S+ + D+ L DI+ V+E+ ++ WF V R G FP +YVK
Sbjct: 877 QALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-----GWFPKSYVK 925
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 786 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 838
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 899 QVDENWYEGRIPGTSRQGIFPITYV 923
+ D +W++G I G + G+FP YV
Sbjct: 1159 KDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 62.0 bits (149), Expect = 4e-09
Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 14/136 (10%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 854
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 855 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 907
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 1020
Query: 908 RIPGTSRQGIFPITYV 923
I R GIFP YV
Sbjct: 1021 SI--GDRSGIFPSNYV 1034
Score = 50.1 bits (118), Expect = 1e-05
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 19/139 (13%)
Query: 727 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 786
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 751
Query: 787 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 844
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 752 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 845 TYIELLPPAEK---AQPKK 860
Y+E +P +E PKK
Sbjct: 811 NYVEKMPSSENEKAVSPKK 829
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 1200 EQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 1259
++ RKA + Q+ + + +T+ L +Y+ALY + +N DE+ GDI+
Sbjct: 729 QEEERKAEEK---QRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQ 785
Query: 1260 VMEKC--DDGWFVGTSRRTKQFGTFPGNYVKPL 1290
V EK + GW G+ + FG FP NYV+ +
Sbjct: 786 VDEKTVGEPGWLYGSFQ--GNFGWFPCNYVEKM 816
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 44.3 bits (103), Expect = 8e-04
Identities = 21/51 (41%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A+Y Y N+DEL G +++VM K D W+ G G FP NYVK
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 39.3 bits (90), Expect = 0.025
Identities = 32/127 (25%), Positives = 56/127 (44%), Gaps = 20/127 (15%)
Query: 814 LQKGDIVY------IYKQIDQNWYEGEHHGRVGIFPRTYI-----ELLPPAEKAQPKKLT 862
++ GD+ + + Q D W+ G R GIFP Y+ E A K+
Sbjct: 995 VEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKK 1054
Query: 863 PVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFP 919
P E + + + +G Q +S G+ I +L++ W++G + G RQ G FP
Sbjct: 1055 P----EIAQVTSAYVASGSEQ--LSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFP 1108
Query: 920 ITYVDVI 926
++V ++
Sbjct: 1109 ASHVKLL 1115
Score = 34.3 bits (77), Expect = 0.79
Identities = 16/57 (28%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1290
Q +Y+ ++L L G ++ +++K GW+ G + + +Q G FP ++VK L
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
Score = 33.9 bits (76), Expect = 1.0
Identities = 38/125 (30%), Positives = 53/125 (42%), Gaps = 11/125 (8%)
Query: 986 SEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHL-SWSDRP 1044
S IS G+ +L++ PLPP + ++ A S P L + P + S S
Sbjct: 110 SPLISARFGMGSMPNLSIPQPLPPAAPITSLSS---ATSGTNLPPLMMPTPLVPSVSTSS 166
Query: 1045 TPRSVASPLA-LPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSV 1103
P AS + LP P+ + +L S SL M G GG Q + + LGSS S
Sbjct: 167 LPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASI------QKAQSLIDLGSSSST 220
Query: 1104 ISQLS 1108
S S
Sbjct: 221 SSTAS 225
Score = 33.9 bits (76), Expect = 1.0
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 1289
Y ALY Y +L +G+ + V +K + W R+ G FP NYVKP
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
Score = 31.6 bits (70), Expect = 5.1
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 7/54 (12%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWF--VGTSRRTKQFGTFPGNYVK 1288
QAL S+ + D+ L DI+ V+E+ ++ WF V R G FP +YVK
Sbjct: 904 QALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-----GWFPKSYVK 952
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 66.6 bits (161), Expect = 1e-10
Identities = 40/145 (27%), Positives = 74/145 (51%), Gaps = 14/145 (9%)
Query: 786 TAKRKSGSEMRP--ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR----- 838
+A + S +P A+ + A ++L L G ++ I K+ W++GE R
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 839 VGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLR 898
G FP ++++LL P+ + PV + IA +++ + + E+SF KG+ I ++
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVC-----QVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 899 QVDENWYEGRIPGTSRQGIFPITYV 923
+ D +W++G I G + G+FP YV
Sbjct: 1159 KDDPDWWQGEINGVT--GLFPSNYV 1181
Score = 62.0 bits (149), Expect = 4e-09
Identities = 44/136 (32%), Positives = 68/136 (50%), Gaps = 14/136 (10%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE--- 854
A+A + A+ L K DI+ + +Q +NW+ GE HG G FP++Y++++P +E
Sbjct: 903 AQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKR 961
Query: 855 -------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 907
A KK T E IA + ++ +++F +GE I L+ Q D W+ G
Sbjct: 962 EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG 1020
Query: 908 RIPGTSRQGIFPITYV 923
I R GIFP YV
Sbjct: 1021 SI--GDRSGIFPSNYV 1034
Score = 50.1 bits (118), Expect = 1e-05
Identities = 35/139 (25%), Positives = 65/139 (46%), Gaps = 19/139 (13%)
Query: 727 EEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDT 786
+E +R+ ++K+K L +++ ++ QEE A + + D L ++
Sbjct: 705 KENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-------------RKDKDTLKAEEK 751
Query: 787 AKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPR 844
KR++ S + RA + F+A+ E+ GDI+ + ++ + W G G G FP
Sbjct: 752 -KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPC 810
Query: 845 TYIELLPPAEK---AQPKK 860
Y+E +P +E PKK
Sbjct: 811 NYVEKMPSSENEKAVSPKK 829
Score = 48.9 bits (115), Expect = 3e-05
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 7/93 (7%)
Query: 1200 EQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 1259
++ RKA + Q+ + + +T+ L +Y+ALY + +N DE+ GDI+
Sbjct: 729 QEEERKAEEK---QRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQ 785
Query: 1260 VMEKC--DDGWFVGTSRRTKQFGTFPGNYVKPL 1290
V EK + GW G+ + FG FP NYV+ +
Sbjct: 786 VDEKTVGEPGWLYGSFQ--GNFGWFPCNYVEKM 816
Score = 45.8 bits (107), Expect = 3e-04
Identities = 17/58 (29%), Positives = 34/58 (58%)
Query: 800 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
A +D+ A EL KG ++ + + D +W++GE +G G+FP Y+++ ++ +Q
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQ 1191
Score = 44.3 bits (103), Expect = 8e-04
Identities = 21/51 (41%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Query: 1238 ALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
A+Y Y N+DEL G +++VM K D W+ G G FP NYVK
Sbjct: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVT--GLFPSNYVK 1182
Score = 39.3 bits (90), Expect = 0.025
Identities = 32/127 (25%), Positives = 56/127 (44%), Gaps = 20/127 (15%)
Query: 814 LQKGDIVY------IYKQIDQNWYEGEHHGRVGIFPRTYI-----ELLPPAEKAQPKKLT 862
++ GD+ + + Q D W+ G R GIFP Y+ E A K+
Sbjct: 995 VEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKK 1054
Query: 863 PVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFP 919
P E + + + +G Q +S G+ I +L++ W++G + G RQ G FP
Sbjct: 1055 P----EIAQVTSAYVASGSEQ--LSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFP 1108
Query: 920 ITYVDVI 926
++V ++
Sbjct: 1109 ASHVKLL 1115
Score = 34.3 bits (77), Expect = 0.79
Identities = 16/57 (28%), Positives = 31/57 (54%), Gaps = 3/57 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1290
Q +Y+ ++L L G ++ +++K GW+ G + + +Q G FP ++VK L
Sbjct: 1059 QVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL 1115
Score = 33.9 bits (76), Expect = 1.0
Identities = 38/125 (30%), Positives = 53/125 (42%), Gaps = 11/125 (8%)
Query: 986 SEWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHL-SWSDRP 1044
S IS G+ +L++ PLPP + ++ A S P L + P + S S
Sbjct: 110 SPLISARFGMGSMPNLSIPQPLPPAAPITSLSS---ATSGTNLPPLMMPTPLVPSVSTSS 166
Query: 1045 TPRSVASPLA-LPSPHKTYSLAPTSQASLHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSV 1103
P AS + LP P+ + +L S SL M G GG Q + + LGSS S
Sbjct: 167 LPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGFGGASI------QKAQSLIDLGSSSST 220
Query: 1104 ISQLS 1108
S S
Sbjct: 221 SSTAS 225
Score = 33.9 bits (76), Expect = 1.0
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 1236 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 1289
Y ALY Y +L +G+ + V +K + W R+ G FP NYVKP
Sbjct: 986 YIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS---GIFPSNYVKP 1036
Score = 31.6 bits (70), Expect = 5.1
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 7/54 (12%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWF--VGTSRRTKQFGTFPGNYVK 1288
QAL S+ + D+ L DI+ V+E+ ++ WF V R G FP +YVK
Sbjct: 904 QALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGR-----GWFPKSYVK 952
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 64.7 bits (156), Expect = 5e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 696 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 750
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 751 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 798
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 853
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 854 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 909
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 910 PGTSRQGIFPITYV 923
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 55.5 bits (132), Expect = 3e-07
Identities = 38/142 (26%), Positives = 72/142 (50%), Gaps = 20/142 (14%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 856
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 857 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 901
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 902 ENWYEGRIPGTSRQGIFPITYV 923
+W+ G + + G+FP YV
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYV 1055
Score = 49.7 bits (117), Expect = 2e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 802 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 47.8 bits (112), Expect = 7e-05
Identities = 25/65 (38%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 1224 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 1283
P +S + +Y Y QNDDEL G I++V+ K D W+ G Q G FP
Sbjct: 1148 PPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFP 1205
Query: 1284 GNYVK 1288
NYVK
Sbjct: 1206 SNYVK 1210
Score = 41.2 bits (95), Expect = 0.006
Identities = 40/179 (22%), Positives = 77/179 (43%), Gaps = 23/179 (12%)
Query: 699 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 758
L++ A + E + ++ E + R+ H++++ + + K +E+ A
Sbjct: 642 LEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEA 701
Query: 759 RRHTGVIPTHHQ----------FITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 808
+ G + HQ + T E+ G L T + ++ RA + F++++
Sbjct: 702 QDKLGRLFHQHQEPAKPAVQAPWSTAEK-GPL-----TISAQENVKVVYYRALYPFESRS 755
Query: 809 LKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 860
E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P E P K
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVK 814
Score = 38.9 bits (89), Expect = 0.032
Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 3/78 (3%)
Query: 1211 GSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 1270
GS + A +RV ++ + A+Y+Y +L + GD++ V +K D W+
Sbjct: 982 GSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWT 1040
Query: 1271 GTSRRTKQFGTFPGNYVK 1288
GT + G FP NYV+
Sbjct: 1041 GTV--GDKAGVFPSNYVR 1056
Score = 38.1 bits (87), Expect = 0.055
Identities = 33/100 (33%), Positives = 49/100 (49%), Gaps = 12/100 (12%)
Query: 862 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 915
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQD-MWWFGEVQG--QK 958
Query: 916 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSP-SRSATASP 954
G FP +YV +I P+ K+ MD S SP S ASP
Sbjct: 959 GWFPKSYVKLISGPIRKS--TSMDSGSSESPASLKRVASP 996
Score = 37.4 bits (85), Expect = 0.094
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1290
Q + SY ++L L G ++ + +K GW+ G + + +Q G FP NYVK L
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 36.6 bits (83), Expect = 0.16
Identities = 31/142 (21%), Positives = 58/142 (40%), Gaps = 13/142 (9%)
Query: 240 SFSPPPPLVPPA--PEDLRRVSEPDLTGAVSSTD------SSPLLNEVSSSLIGTDSQAF 291
S P PP++PP P RRV +SST P+L + L F
Sbjct: 291 SGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTF 350
Query: 292 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----E 346
+ + + + LL+ R++Q+RL+ L ER+ E+ + E
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
Query: 347 KPTSPGKAIEKRAKDDSRRVVK 368
K + +E++ +++ R+ ++
Sbjct: 411 KQLEKQRELERQREEERRKEIE 432
Score = 35.4 bits (80), Expect = 0.36
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
QALY + + D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 35.0 bits (79), Expect = 0.46
Identities = 26/115 (22%), Positives = 51/115 (44%), Gaps = 15/115 (13%)
Query: 1189 EAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDR------SQTSQDLFSYQALYSY 1242
+ E+ + ++ GR + +P Q T ++ +Q + + Y+ALY +
Sbjct: 692 DGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPF 751
Query: 1243 IPQNDDELELRDGDI-------VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
++ DE+ ++ GDI VD + + GW G + + G FP NY + +
Sbjct: 752 ESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
Score = 33.1 bits (74), Expect = 1.8
Identities = 40/165 (24%), Positives = 61/165 (36%), Gaps = 16/165 (9%)
Query: 83 PSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLP 142
P S + + R + GL P+P A W L AD N + + + S+ L
Sbjct: 34 PISGFITGDQARNFFFQSGL-PQPVLAQIWAL---ADMNNDGRMDQVEF----SIAMKLI 85
Query: 143 SDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEG--------TARPPTPLGPLGCVPTIPA 194
K Q SA P + P+ + + G TA P P+G + V P
Sbjct: 86 KLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPT 145
Query: 195 TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPP 239
S+ P L + PP +Q P + PA + S++ P
Sbjct: 146 LVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 64.7 bits (156), Expect = 5e-10
Identities = 64/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%)
Query: 696 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEKLLADQRRLKRE 750
+SG R S+S + SESP A + S EEFI + ++Q L +
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYES----SEQGDLTFQ 1024
Query: 751 QEEADIAARRH-----------TGVIPTHHQFITNERFGDLLNIDDTAKRKS-GSEMRPA 798
Q + + ++ GV P+++ R D K S G + A
Sbjct: 1025 QGDVILVTKKDGDWWTGTVGDKAGVFPSNYV-----RLKDSEGSGTAGKTGSLGKKPEIA 1079
Query: 799 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGR-----VGIFPRTYIELLPPA 853
+ + A ++L L G ++ I K+ W+EGE R +G FP Y++LL P
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 854 EK----AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRI 909
+P K T + + + I +++ E++F KG+ I +L + D +W++G +
Sbjct: 1140 TSKITPTEPPKSTALAAV--CQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 910 PGTSRQGIFPITYV 923
G + G+FP YV
Sbjct: 1198 NG--QVGLFPSNYV 1209
Score = 55.5 bits (132), Expect = 3e-07
Identities = 38/142 (26%), Positives = 72/142 (50%), Gaps = 20/142 (14%)
Query: 798 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-PAEKA 856
A+A + ++A+ L K D++ + +Q D W+ GE G+ G FP++Y++L+ P K+
Sbjct: 918 AQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRKS 976
Query: 857 ---------QPKKLTPV------QVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVD 901
P L V V+ E IA + + Q +++F++G+ + L+ + D
Sbjct: 977 TSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGD-VILVTKKD 1035
Query: 902 ENWYEGRIPGTSRQGIFPITYV 923
+W+ G + + G+FP YV
Sbjct: 1036 GDWWTGTV--GDKAGVFPSNYV 1055
Score = 49.7 bits (117), Expect = 2e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 802 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 857
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 47.8 bits (112), Expect = 7e-05
Identities = 25/65 (38%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 1224 PDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFP 1283
P +S + +Y Y QNDDEL G I++V+ K D W+ G Q G FP
Sbjct: 1148 PPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFP 1205
Query: 1284 GNYVK 1288
NYVK
Sbjct: 1206 SNYVK 1210
Score = 41.2 bits (95), Expect = 0.006
Identities = 40/179 (22%), Positives = 77/179 (43%), Gaps = 23/179 (12%)
Query: 699 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 758
L++ A + E + ++ E + R+ H++++ + + K +E+ A
Sbjct: 642 LEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEA 701
Query: 759 RRHTGVIPTHHQ----------FITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQT 808
+ G + HQ + T E+ G L T + ++ RA + F++++
Sbjct: 702 QDKLGRLFHQHQEPAKPAVQAPWSTAEK-GPL-----TISAQENVKVVYYRALYPFESRS 755
Query: 809 LKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 860
E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P E P K
Sbjct: 756 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVK 814
Score = 38.9 bits (89), Expect = 0.032
Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 3/78 (3%)
Query: 1211 GSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFV 1270
GS + A +RV ++ + A+Y+Y +L + GD++ V +K D W+
Sbjct: 982 GSSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK-DGDWWT 1040
Query: 1271 GTSRRTKQFGTFPGNYVK 1288
GT + G FP NYV+
Sbjct: 1041 GTV--GDKAGVFPSNYVR 1056
Score = 38.1 bits (87), Expect = 0.055
Identities = 33/100 (33%), Positives = 49/100 (49%), Gaps = 12/100 (12%)
Query: 862 TPVQVLEYGEAI------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 915
+P VL GE + A + + ++F K + IT+L Q D W+ G + G ++
Sbjct: 902 SPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQD-MWWFGEVQG--QK 958
Query: 916 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSP-SRSATASP 954
G FP +YV +I P+ K+ MD S SP S ASP
Sbjct: 959 GWFPKSYVKLISGPIRKS--TSMDSGSSESPASLKRVASP 996
Score = 37.4 bits (85), Expect = 0.094
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 1290
Q + SY ++L L G ++ + +K GW+ G + + +Q G FP NYVK L
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 36.6 bits (83), Expect = 0.16
Identities = 31/142 (21%), Positives = 58/142 (40%), Gaps = 13/142 (9%)
Query: 240 SFSPPPPLVPPA--PEDLRRVSEPDLTGAVSSTD------SSPLLNEVSSSLIGTDSQAF 291
S P PP++PP P RRV +SST P+L + L F
Sbjct: 291 SGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTF 350
Query: 292 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----E 346
+ + + + LL+ R++Q+RL+ L ER+ E+ + E
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
Query: 347 KPTSPGKAIEKRAKDDSRRVVK 368
K + +E++ +++ R+ ++
Sbjct: 411 KQLEKQRELERQREEERRKEIE 432
Score = 35.4 bits (80), Expect = 0.36
Identities = 19/52 (36%), Positives = 27/52 (51%), Gaps = 3/52 (5%)
Query: 1237 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 1288
QALY + + D+ L D++ V+E+ D WF Q G FP +YVK
Sbjct: 919 QALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSYVK 967
Score = 35.0 bits (79), Expect = 0.46
Identities = 26/115 (22%), Positives = 51/115 (44%), Gaps = 15/115 (13%)
Query: 1189 EAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDR------SQTSQDLFSYQALYSY 1242
+ E+ + ++ GR + +P Q T ++ +Q + + Y+ALY +
Sbjct: 692 DGEEKGKQEAQDKLGRLFHQHQEPAKPAVQAPWSTAEKGPLTISAQENVKVVYYRALYPF 751
Query: 1243 IPQNDDELELRDGDI-------VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
++ DE+ ++ GDI VD + + GW G + + G FP NY + +
Sbjct: 752 ESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
Score = 33.1 bits (74), Expect = 1.8
Identities = 40/165 (24%), Positives = 61/165 (36%), Gaps = 16/165 (9%)
Query: 83 PSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLP 142
P S + + R + GL P+P A W L AD N + + + S+ L
Sbjct: 34 PISGFITGDQARNFFFQSGL-PQPVLAQIWAL---ADMNNDGRMDQVEF----SIAMKLI 85
Query: 143 SDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEG--------TARPPTPLGPLGCVPTIPA 194
K Q SA P + P+ + + G TA P P+G + V P
Sbjct: 86 KLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPT 145
Query: 195 TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPP 239
S+ P L + PP +Q P + PA + S++ P
Sbjct: 146 LVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.373
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,131,529
Number of Sequences: 37866
Number of extensions: 3323649
Number of successful extensions: 20679
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 227
Number of HSP's successfully gapped in prelim test: 802
Number of HSP's that attempted gapping in prelim test: 15704
Number of HSP's gapped (non-prelim): 4667
length of query: 1292
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1178
effective length of database: 13,930,794
effective search space: 16410475332
effective search space used: 16410475332
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.