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Search of human proteins with 7705831
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705831 ankyrin repeat and SOCS box-containing protein 3
isoform a [Homo sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 1053 0.0
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 907 0.0
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 192 6e-49
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 189 7e-48
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 159 6e-39
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 159 6e-39
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 159 6e-39
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 159 6e-39
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 159 6e-39
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 150 2e-36
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 150 2e-36
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 150 2e-36
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 146 4e-35
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 142 1e-33
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 139 6e-33
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 128 1e-29
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 128 1e-29
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 125 1e-28
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 125 1e-28
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 124 2e-28
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 122 6e-28
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 122 1e-27
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 122 1e-27
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 121 1e-27
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 121 1e-27
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 116 4e-26
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 112 6e-25
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 111 2e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 110 2e-24
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 110 2e-24
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 1053 bits (2724), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ
Sbjct: 1 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
Query: 61 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 120
MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV
Sbjct: 61 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 120
Query: 121 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI
Sbjct: 121 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
Query: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL
Sbjct: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
Query: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL
Sbjct: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Query: 301 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI 360
RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI
Sbjct: 301 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSI 360
Query: 361 FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID 420
FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID
Sbjct: 361 FRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSID 420
Query: 421 TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR 480
TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR
Sbjct: 421 TLIFTLEFTNWKTLAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLR 480
Query: 481 SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG 518
SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
Sbjct: 481 SDSYISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG 518
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 907 bits (2344), Expect = 0.0
Identities = 445/445 (100%), Positives = 445/445 (100%)
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ
Sbjct: 1 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
Query: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE
Sbjct: 61 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 120
Query: 194 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 253
SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA
Sbjct: 121 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 180
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 313
AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV
Sbjct: 181 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 240
Query: 314 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP 373
FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP
Sbjct: 241 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHLAYCLKYEKFSIFRYFLRKGCSLGP 300
Query: 374 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT 433
WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT
Sbjct: 301 WNHIYEFVNHAIKAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKT 360
Query: 434 LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS 493
LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS
Sbjct: 361 LAPAVERMLSARASNAWILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRS 420
Query: 494 LHNYLLYEDVLRMYEVPELAAIQDG 518
LHNYLLYEDVLRMYEVPELAAIQDG
Sbjct: 421 LHNYLLYEDVLRMYEVPELAAIQDG 445
Score = 68.9 bits (167), Expect = 1e-11
Identities = 56/199 (28%), Positives = 107/199 (53%), Gaps = 15/199 (7%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A+ + N ++++ LL+KG + + D+ G P+ AA + +E L +LI++ ++ N +
Sbjct: 80 ASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVN---CQA 136
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET--TPLFLAVENGQIDVLRLL--L 132
+ L +AA +GH K V++LL +GADP+ E++ P+ A + G +L LL L
Sbjct: 137 LDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 196
Query: 133 QHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD--DFGI-TPLFVAAQY 189
+ A G + + + ++ A F + + +++LLR G + + Q FG +P+ +A Q
Sbjct: 197 TNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQK 253
Query: 190 G--KLESLSILISSGANVN 206
++IL+ GA +N
Sbjct: 254 DCEFFGIVNILLKYGAQIN 272
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 192 bits (488), Expect = 6e-49
Identities = 146/543 (26%), Positives = 263/543 (48%), Gaps = 78/543 (14%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A ++G+ + L+ ++K+G+++ + GW+P+HEAAY+ V CL++L A I +T
Sbjct: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT--IDQRT 121
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
+ A++LA +GH + LL+AGA+P+ + TPL+ A E + +++L+QH A
Sbjct: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
+ N + GW +LH++ + + E++++L+ GA E ++ +GITPLFVAAQ G+LE+L
Sbjct: 182 DTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
Query: 197 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQ 256
L GA++N QA D A+ L+ A + H + VE LLS GAD + N+D LP+H A++
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK-TNKDGL-LPLHIASK 298
Query: 257 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLE------------------- 297
G+ +I+ +L+P+T+R + VSP++ A H++ LE
Sbjct: 299 KGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
Query: 298 -----------------------ILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIV 334
+LL++G P+ SP+ +A + C +
Sbjct: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI------SPLLVAIRHGC--LRTM 409
Query: 335 NILLKYGAQINELHLAYCLKYEK--------FSIFRYFLRKGCSLGP-WNHIYEFVNHAI 385
+LL +GA I+ + + S+ ++ + GC P ++ +Y H
Sbjct: 410 QLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPP 469
Query: 386 KAQAKYKEWLPHLLVAGFDPLILLCNSWIDSVSIDT-----LIFTLEFTNWKTLAPAVER 440
Q + A +P ++ ++ + + + L++ L ++
Sbjct: 470 APQPSSR--FNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKE 527
Query: 441 MLSARASNAWILQQHIATVPS-LTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLL 499
+ + W + + A P L HLCRL +R ++ R++ + LPLP L YL
Sbjct: 528 HIDSFED--WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLK 582
Query: 500 YED 502
YE+
Sbjct: 583 YEN 585
Score = 92.4 bits (228), Expect = 9e-19
Identities = 84/350 (24%), Positives = 150/350 (42%), Gaps = 83/350 (23%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
+ V LA G++ L LL+ G D+++ P+++A + E +++L+ ++ N+
Sbjct: 126 TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNH 185
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
+ G+ ALH + S+ +++QIL+ GA + TPLF+A ++GQ++ LR L
Sbjct: 186 ---RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFL 242
Query: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGA--NKECQDDF----------- 178
++GA++N + + ++L++A E+ E+++ LL +GA NK +D
Sbjct: 243 AKYGADIN-TQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGN 301
Query: 179 -------------------GITPLFVAAQYGKLESLSILISSGANVNCQAL--------- 210
G++PL +AA+ E L L+S+ +VN
Sbjct: 302 YRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYED 361
Query: 211 ------------------------------DKATPLFIAAQEGHTKCVELLLSSGADPDL 240
D +PL +A + G + ++LLL GA+ D
Sbjct: 362 RRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
Query: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFG 290
Y P A M K L LL L + CD P +S ++G
Sbjct: 422 YIATHPTAFP---ATIMFAMKCLSLLKFLMDLGCDG-----EPCFSCLYG 463
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/243 (23%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 110 LEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169
L PL A+++G + L+ +++ G N+ + GW LH+A++ +K+L R
Sbjct: 55 LAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
Query: 170 A----NKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 225
+ Q++ T +++A G L+ L L+ +GA + + TPL+ A + +
Sbjct: 114 PGTIDQRTLQEE---TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA 170
Query: 226 KCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY 285
+ V++L+ AD + CN W +H + +++ +L+ + ++P++
Sbjct: 171 EAVKILVQHNADTNHRCNR-GW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
Query: 286 SAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC--EFFGIVNILLKYGAQ 343
A G + L L + G + QA S A + C E +V LL GA
Sbjct: 229 VAAQSGQLEALRFLAKYGADINTQA-------SDNASALYEACKNEHEEVVEFLLSQGAD 281
Query: 344 INE 346
N+
Sbjct: 282 ANK 284
Score = 65.1 bits (157), Expect = 1e-10
Identities = 59/239 (24%), Positives = 95/239 (39%), Gaps = 51/239 (21%)
Query: 2 DFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQM 61
D +D S + A + + +V+ LL +G + + G +P+H A+ + +QM
Sbjct: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307
Query: 62 LINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--------- 112
L+ S + G LHLAA + H ++++ LL A D N E
Sbjct: 308 LLPVTSRTRIRR----SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRR 363
Query: 113 TTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANK 172
++ L+ AV N + LLLQHGA+ N
Sbjct: 364 SSALYFAVVNNNVYATELLLQHGADPNRD------------------------------- 392
Query: 173 ECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 231
I+PL VA ++G L ++ +L+ GAN++ T F A KC+ LL
Sbjct: 393 ------VISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPT-AFPATIMFAMKCLSLL 444
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 189 bits (479), Expect = 7e-48
Identities = 147/538 (27%), Positives = 260/538 (48%), Gaps = 62/538 (11%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A ++G++ L++ +K ++D AD +GW P+HEA + L+++++A S + + KT
Sbjct: 50 AIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDA-SYKTLWEFKT 108
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
+G L LA G + V+ LLE G PN + TPL +AV+ G D++ L++H
Sbjct: 109 CDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKHNT 168
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
+++ + W+++H+A+ Q +I+ LLL+ G N +D FG+TPL VAA+YG + L
Sbjct: 169 SLD-QPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVLE 227
Query: 197 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQ 256
LI G +V A D A+ LF AA G+ C+ LLL G ++ + LPIH AA
Sbjct: 228 HLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNV--PNRAGHLPIHRAAY 285
Query: 257 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG------------- 303
GH L LIP+T++ + ++P++SA G + CLE+L+ NG
Sbjct: 286 EGHYLALKYLIPVTSKNA-IRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQ 344
Query: 304 -YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGIVNILLKYGA 342
Y + + L FG S+ P+ C+ + IV +LL +GA
Sbjct: 345 SYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGA 404
Query: 343 QIN--ELH---------LAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKY 391
+N +H + Y L E + R L G + ++ ++ I +
Sbjct: 405 NVNCYFMHVNDTRFPSVIQYALNDE--VMLRLLLNNGYQV---EMCFDCMHGDIFGNSFV 459
Query: 392 KEWLPHLLVAGFDPLILLCNSWIDSVSIDTL-----IFTLEFTNWKTLAPAVERMLSA-R 445
+ ++ G+ ++ N + + +++ + T ++ P ++ SA
Sbjct: 460 WSEIQEEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALE 519
Query: 446 ASNAW-ILQQHIATVPSLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
W ++Q + SL HLCRL+IR + ++L + + +LPLP ++ Y+L+++
Sbjct: 520 VQREWPEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFKE 577
Score = 86.3 bits (212), Expect = 6e-17
Identities = 61/234 (26%), Positives = 112/234 (47%), Gaps = 14/234 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+A ++G+ ++ L+K S+D + W +HEAA + + +L+ + + ++
Sbjct: 150 IAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGN---VHLR 206
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G L +AA GH +++ L+ G D A + + LF A G D + LLL++G
Sbjct: 207 DGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYG 266
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
+ N + G +H+A+++ + +K L+ +K G+TP+ AA + L
Sbjct: 267 GSGN-VPNRAGHLPIHRAAYEGHYLALKYLI-PVTSKNAIRKSGLTPIHSAADGQNAQCL 324
Query: 196 SILISSGANVNCQALD---------KATPLFIAAQEGHTKCVELLLSSGADPDL 240
+LI +G +VN D + T L+ C E+LL++GADP+L
Sbjct: 325 ELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNL 378
Score = 67.4 bits (163), Expect = 3e-11
Identities = 61/233 (26%), Positives = 102/233 (43%), Gaps = 18/233 (7%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
+G+AA G+ VL L+ KG V + G + EAA + +C+ +L+ S N
Sbjct: 214 LGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGN--- 270
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
+ G +H AA +GH+ ++ L+ NA TP+ A + L LL++
Sbjct: 271 VPNRAGHLPIHRAAYEGHYLALKYLIPV-TSKNAIRKSGLTPIHSAADGQNAQCLELLIE 329
Query: 134 HGANVN---GSHSMCGWN-----SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFV 185
+G +VN H ++ +L+ + ++LL GA+ + L V
Sbjct: 330 NGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGADPNLDP---LNCLLV 386
Query: 186 AAQYGKLESLSILISSGANVNCQAL---DKATPLFIAAQEGHTKCVELLLSSG 235
A + E + +L+S GANVNC + D P I + LLL++G
Sbjct: 387 AVRANNYEIVRLLLSHGANVNCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNG 439
Score = 67.0 bits (162), Expect = 4e-11
Identities = 56/175 (32%), Positives = 80/175 (45%), Gaps = 17/175 (9%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D S + AA GN + LL+ G S +V + G +PIH AAY L+ LI +S
Sbjct: 242 DGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGHYLALKYLIPV-TS 300
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTL---------EETTPLFLA 119
+N I+ G +H AA + + +++L+E G D N E T L+
Sbjct: 301 KNAIRK---SGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSYDDERKTALYFG 357
Query: 120 VENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKEC 174
V N + +LL GA+ N + N L A N EI++LLL GAN C
Sbjct: 358 VSNNDVHCTEVLLAAGADPN----LDPLNCLLVAVRANNYEIVRLLLSHGANVNC 408
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 159 bits (402), Expect = 6e-39
Identities = 112/368 (30%), Positives = 179/368 (48%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+V++ LL G + G PIH AA + ++C+++L+ D+
Sbjct: 304 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ I T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+
Sbjct: 364 IDDI---TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 420
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+ GA+++ + G LH ASF + I+K LL++GA+ + TPL +AA+
Sbjct: 421 ELLLKTGASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 479
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL-------- 240
G E L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 480 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 539
Query: 241 -----------------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277
C P+H AA+ G ++ +LL+ G
Sbjct: 540 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ AV + D +++LL G SP + A G++ A Q E + L
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSL 654
Query: 338 LKYGAQIN 345
L+YG N
Sbjct: 655 LQYGGSAN 662
Score = 150 bits (379), Expect = 3e-36
Identities = 124/432 (28%), Positives = 209/432 (48%), Gaps = 54/432 (12%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL A++EG+VK++ +LL K ++ +G +H AA E ++ L+
Sbjct: 72 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 131
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
N ++ N K GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G
Sbjct: 132 NYGANVNAQSQK---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188
Query: 124 QIDVLRLLLQHGAN----VNGSH------------------------SMCGWNSLHQASF 155
+V+ L+ +G + H S G+ LH A+
Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 248
Query: 156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
EN + +LLL +GA+ GITPL +A++ G + + +L+ GA + + D+ TP
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Query: 216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 275
L AA+ GH + E+LL GA + + PIH AAQ H + LL+ D
Sbjct: 309 LHCAARNGHVRISEILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 276 TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN 335
L+ ++P++ A GH ++LL G P+++A F +P+ +A +K+ ++
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVME 421
Query: 336 ILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
+LLK GA I+ LH+A + + I + L++G S N E H + A
Sbjct: 422 LLLKTGASIDAVTESGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAA 478
Query: 388 QAKYKEWLPHLL 399
+A + E +LL
Sbjct: 479 RAGHTEVAKYLL 490
Score = 145 bits (366), Expect = 9e-35
Identities = 91/295 (30%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR + + LL+ + DV G+ P+H AA++ ++ Q+L+N +S N+
Sbjct: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G LH+A+ +G+ +V++LL+ GA T +E TPL A NG + + +LL HG
Sbjct: 272 ---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + + G + +H A+ ++ + ++LLL+ A + +TPL VAA G
Sbjct: 329 APIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ GA N +AL+ TPL IA ++ H + +ELLL +GA D +S P+H A+
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT--ESGLTPLHVAS 445
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 310
MGH I+ L+ + + +P++ A GH + + LL+N +A+A
Sbjct: 446 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 500
Score = 144 bits (363), Expect = 2e-34
Identities = 108/332 (32%), Positives = 167/332 (50%), Gaps = 11/332 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G+ +V + LL+ V+ P+H AA +++L+ +++ N +
Sbjct: 476 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN---LA 532
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 533 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 592
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 593 AHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 651
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H A
Sbjct: 652 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHLVA 709
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFG 315
Q GH + D+LI T +P++ A G+ ++ LL+ + D A G
Sbjct: 710 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLG 767
Query: 316 FSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 347
+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 768 Y-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 796
Score = 133 bits (335), Expect = 3e-31
Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 55/419 (13%)
Query: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
AD ++ AAR GN+ L+ G ++ + G +H A+ V+ + L++
Sbjct: 43 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH--- 99
Query: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 127
E ++ T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V
Sbjct: 100 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 159
Query: 128 LRLLLQHGANVN----------------------------GSHSMCGWNSLHQASFQENA 159
++ LL++GAN N G+ +LH A+ ++
Sbjct: 160 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 219
Query: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
+LL+ N + G TPL +AA Y L +L++ GA+VN + TPL IA
Sbjct: 220 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 279
Query: 220 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 279
++ G+ V LLL GA + ++ P+H AA+ GH +I ++L+ N
Sbjct: 280 SRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKN 337
Query: 280 KVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLK 339
+SP++ A G H DC+ +LL+ D + +P+ +A C + +LL
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLD 392
Query: 340 YGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 383
GA+ N LH+A K + L+ G S+ H+ F+ H
Sbjct: 393 KGAKPNSRALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 449
Score = 132 bits (331), Expect = 1e-30
Identities = 79/257 (30%), Positives = 140/257 (54%), Gaps = 8/257 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G V+V LL++ + A G P+H A +HN+++ +++L+ S +
Sbjct: 575 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH---SP 631
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 136 ANVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 194
AN N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++
Sbjct: 692 ANGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
+ L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIA 807
Query: 255 AQMGHTKILDLLIPLTN 271
++G+ + D+L +T+
Sbjct: 808 KRLGYISVTDVLKVVTD 824
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 159 bits (402), Expect = 6e-39
Identities = 112/368 (30%), Positives = 179/368 (48%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+V++ LL G + G PIH AA + ++C+++L+ D+
Sbjct: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ I T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+
Sbjct: 331 IDDI---TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+ GA+++ + G LH ASF + I+K LL++GA+ + TPL +AA+
Sbjct: 388 ELLLKTGASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL-------- 240
G E L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 241 -----------------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277
C P+H AA+ G ++ +LL+ G
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ AV + D +++LL G SP + A G++ A Q E + L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSL 621
Query: 338 LKYGAQIN 345
L+YG N
Sbjct: 622 LQYGGSAN 629
Score = 150 bits (379), Expect = 3e-36
Identities = 124/432 (28%), Positives = 209/432 (48%), Gaps = 54/432 (12%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL A++EG+VK++ +LL K ++ +G +H AA E ++ L+
Sbjct: 39 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
N ++ N K GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G
Sbjct: 99 NYGANVNAQSQK---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 124 QIDVLRLLLQHGAN----VNGSH------------------------SMCGWNSLHQASF 155
+V+ L+ +G + H S G+ LH A+
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
EN + +LLL +GA+ GITPL +A++ G + + +L+ GA + + D+ TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 275
L AA+ GH + E+LL GA + + PIH AAQ H + LL+ D
Sbjct: 276 LHCAARNGHVRISEILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 276 TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN 335
L+ ++P++ A GH ++LL G P+++A F +P+ +A +K+ ++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVME 388
Query: 336 ILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
+LLK GA I+ LH+A + + I + L++G S N E H + A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAA 445
Query: 388 QAKYKEWLPHLL 399
+A + E +LL
Sbjct: 446 RAGHTEVAKYLL 457
Score = 145 bits (366), Expect = 9e-35
Identities = 91/295 (30%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR + + LL+ + DV G+ P+H AA++ ++ Q+L+N +S N+
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G LH+A+ +G+ +V++LL+ GA T +E TPL A NG + + +LL HG
Sbjct: 239 ---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + + G + +H A+ ++ + ++LLL+ A + +TPL VAA G
Sbjct: 296 APIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ GA N +AL+ TPL IA ++ H + +ELLL +GA D +S P+H A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT--ESGLTPLHVAS 412
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 310
MGH I+ L+ + + +P++ A GH + + LL+N +A+A
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 144 bits (363), Expect = 2e-34
Identities = 108/332 (32%), Positives = 167/332 (50%), Gaps = 11/332 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G+ +V + LL+ V+ P+H AA +++L+ +++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN---LA 499
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 560 AHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H A
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHLVA 676
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFG 315
Q GH + D+LI T +P++ A G+ ++ LL+ + D A G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLG 734
Query: 316 FSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 347
+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 735 Y-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 133 bits (335), Expect = 3e-31
Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 55/419 (13%)
Query: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
AD ++ AAR GN+ L+ G ++ + G +H A+ V+ + L++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH--- 66
Query: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 127
E ++ T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 128 LRLLLQHGANVN----------------------------GSHSMCGWNSLHQASFQENA 159
++ LL++GAN N G+ +LH A+ ++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
+LL+ N + G TPL +AA Y L +L++ GA+VN + TPL IA
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 220 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 279
++ G+ V LLL GA + ++ P+H AA+ GH +I ++L+ N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 280 KVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLK 339
+SP++ A G H DC+ +LL+ D + +P+ +A C + +LL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLD 359
Query: 340 YGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 383
GA+ N LH+A K + L+ G S+ H+ F+ H
Sbjct: 360 KGAKPNSRALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 132 bits (331), Expect = 1e-30
Identities = 79/257 (30%), Positives = 140/257 (54%), Gaps = 8/257 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G V+V LL++ + A G P+H A +HN+++ +++L+ S +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH---SP 598
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 136 ANVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 194
AN N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++
Sbjct: 659 ANGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
+ L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIA 774
Query: 255 AQMGHTKILDLLIPLTN 271
++G+ + D+L +T+
Sbjct: 775 KRLGYISVTDVLKVVTD 791
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 159 bits (402), Expect = 6e-39
Identities = 112/368 (30%), Positives = 179/368 (48%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+V++ LL G + G PIH AA + ++C+++L+ D+
Sbjct: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ I T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+
Sbjct: 331 IDDI---TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+ GA+++ + G LH ASF + I+K LL++GA+ + TPL +AA+
Sbjct: 388 ELLLKTGASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL-------- 240
G E L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 241 -----------------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277
C P+H AA+ G ++ +LL+ G
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ AV + D +++LL G SP + A G++ A Q E + L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSL 621
Query: 338 LKYGAQIN 345
L+YG N
Sbjct: 622 LQYGGSAN 629
Score = 150 bits (379), Expect = 3e-36
Identities = 124/432 (28%), Positives = 209/432 (48%), Gaps = 54/432 (12%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL A++EG+VK++ +LL K ++ +G +H AA E ++ L+
Sbjct: 39 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
N ++ N K GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G
Sbjct: 99 NYGANVNAQSQK---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 124 QIDVLRLLLQHGAN----VNGSH------------------------SMCGWNSLHQASF 155
+V+ L+ +G + H S G+ LH A+
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
EN + +LLL +GA+ GITPL +A++ G + + +L+ GA + + D+ TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 275
L AA+ GH + E+LL GA + + PIH AAQ H + LL+ D
Sbjct: 276 LHCAARNGHVRISEILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 276 TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN 335
L+ ++P++ A GH ++LL G P+++A F +P+ +A +K+ ++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVME 388
Query: 336 ILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
+LLK GA I+ LH+A + + I + L++G S N E H + A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAA 445
Query: 388 QAKYKEWLPHLL 399
+A + E +LL
Sbjct: 446 RAGHTEVAKYLL 457
Score = 145 bits (366), Expect = 9e-35
Identities = 91/295 (30%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR + + LL+ + DV G+ P+H AA++ ++ Q+L+N +S N+
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G LH+A+ +G+ +V++LL+ GA T +E TPL A NG + + +LL HG
Sbjct: 239 ---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + + G + +H A+ ++ + ++LLL+ A + +TPL VAA G
Sbjct: 296 APIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ GA N +AL+ TPL IA ++ H + +ELLL +GA D +S P+H A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT--ESGLTPLHVAS 412
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 310
MGH I+ L+ + + +P++ A GH + + LL+N +A+A
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 144 bits (363), Expect = 2e-34
Identities = 108/332 (32%), Positives = 167/332 (50%), Gaps = 11/332 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G+ +V + LL+ V+ P+H AA +++L+ +++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN---LA 499
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 560 AHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H A
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHLVA 676
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFG 315
Q GH + D+LI T +P++ A G+ ++ LL+ + D A G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLG 734
Query: 316 FSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 347
+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 735 Y-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 133 bits (335), Expect = 3e-31
Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 55/419 (13%)
Query: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
AD ++ AAR GN+ L+ G ++ + G +H A+ V+ + L++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH--- 66
Query: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 127
E ++ T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 128 LRLLLQHGANVN----------------------------GSHSMCGWNSLHQASFQENA 159
++ LL++GAN N G+ +LH A+ ++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
+LL+ N + G TPL +AA Y L +L++ GA+VN + TPL IA
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 220 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 279
++ G+ V LLL GA + ++ P+H AA+ GH +I ++L+ N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 280 KVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLK 339
+SP++ A G H DC+ +LL+ D + +P+ +A C + +LL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLD 359
Query: 340 YGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 383
GA+ N LH+A K + L+ G S+ H+ F+ H
Sbjct: 360 KGAKPNSRALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 132 bits (331), Expect = 1e-30
Identities = 79/257 (30%), Positives = 140/257 (54%), Gaps = 8/257 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G V+V LL++ + A G P+H A +HN+++ +++L+ S +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH---SP 598
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 136 ANVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 194
AN N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++
Sbjct: 659 ANGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
+ L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIA 774
Query: 255 AQMGHTKILDLLIPLTN 271
++G+ + D+L +T+
Sbjct: 775 KRLGYISVTDVLKVVTD 791
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 159 bits (402), Expect = 6e-39
Identities = 112/368 (30%), Positives = 179/368 (48%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+V++ LL G + G PIH AA + ++C+++L+ D+
Sbjct: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ I T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+
Sbjct: 331 IDDI---TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+ GA+++ + G LH ASF + I+K LL++GA+ + TPL +AA+
Sbjct: 388 ELLLKTGASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL-------- 240
G E L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 241 -----------------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277
C P+H AA+ G ++ +LL+ G
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ AV + D +++LL G SP + A G++ A Q E + L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSL 621
Query: 338 LKYGAQIN 345
L+YG N
Sbjct: 622 LQYGGSAN 629
Score = 150 bits (379), Expect = 3e-36
Identities = 124/432 (28%), Positives = 209/432 (48%), Gaps = 54/432 (12%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL A++EG+VK++ +LL K ++ +G +H AA E ++ L+
Sbjct: 39 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
N ++ N K GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G
Sbjct: 99 NYGANVNAQSQK---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 124 QIDVLRLLLQHGAN----VNGSH------------------------SMCGWNSLHQASF 155
+V+ L+ +G + H S G+ LH A+
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
EN + +LLL +GA+ GITPL +A++ G + + +L+ GA + + D+ TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 275
L AA+ GH + E+LL GA + + PIH AAQ H + LL+ D
Sbjct: 276 LHCAARNGHVRISEILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 276 TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN 335
L+ ++P++ A GH ++LL G P+++A F +P+ +A +K+ ++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVME 388
Query: 336 ILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
+LLK GA I+ LH+A + + I + L++G S N E H + A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAA 445
Query: 388 QAKYKEWLPHLL 399
+A + E +LL
Sbjct: 446 RAGHTEVAKYLL 457
Score = 145 bits (366), Expect = 9e-35
Identities = 91/295 (30%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR + + LL+ + DV G+ P+H AA++ ++ Q+L+N +S N+
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G LH+A+ +G+ +V++LL+ GA T +E TPL A NG + + +LL HG
Sbjct: 239 ---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + + G + +H A+ ++ + ++LLL+ A + +TPL VAA G
Sbjct: 296 APIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ GA N +AL+ TPL IA ++ H + +ELLL +GA D +S P+H A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT--ESGLTPLHVAS 412
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 310
MGH I+ L+ + + +P++ A GH + + LL+N +A+A
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 144 bits (363), Expect = 2e-34
Identities = 108/332 (32%), Positives = 167/332 (50%), Gaps = 11/332 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G+ +V + LL+ V+ P+H AA +++L+ +++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN---LA 499
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 560 AHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H A
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHLVA 676
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFG 315
Q GH + D+LI T +P++ A G+ ++ LL+ + D A G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLG 734
Query: 316 FSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 347
+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 735 Y-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 133 bits (335), Expect = 3e-31
Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 55/419 (13%)
Query: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
AD ++ AAR GN+ L+ G ++ + G +H A+ V+ + L++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH--- 66
Query: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 127
E ++ T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 128 LRLLLQHGANVN----------------------------GSHSMCGWNSLHQASFQENA 159
++ LL++GAN N G+ +LH A+ ++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
+LL+ N + G TPL +AA Y L +L++ GA+VN + TPL IA
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 220 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 279
++ G+ V LLL GA + ++ P+H AA+ GH +I ++L+ N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 280 KVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLK 339
+SP++ A G H DC+ +LL+ D + +P+ +A C + +LL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLD 359
Query: 340 YGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 383
GA+ N LH+A K + L+ G S+ H+ F+ H
Sbjct: 360 KGAKPNSRALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 132 bits (331), Expect = 1e-30
Identities = 79/257 (30%), Positives = 140/257 (54%), Gaps = 8/257 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G V+V LL++ + A G P+H A +HN+++ +++L+ S +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH---SP 598
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 136 ANVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 194
AN N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++
Sbjct: 659 ANGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
+ L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIA 774
Query: 255 AQMGHTKILDLLIPLTN 271
++G+ + D+L +T+
Sbjct: 775 KRLGYISVTDVLKVVTD 791
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 159 bits (402), Expect = 6e-39
Identities = 112/368 (30%), Positives = 179/368 (48%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+V++ LL G + G PIH AA + ++C+++L+ D+
Sbjct: 271 DELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ I T + LH+AA GH ++ ++LL+ GA PN+ L TPL +A + + V+
Sbjct: 331 IDDI---TLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVM 387
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+ GA+++ + G LH ASF + I+K LL++GA+ + TPL +AA+
Sbjct: 388 ELLLKTGASIDAV-TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 446
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL-------- 240
G E L+ + A VN +A D TPL AA+ GHT V+LLL + A+P+L
Sbjct: 447 AGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTP 506
Query: 241 -----------------------YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277
C P+H AA+ G ++ +LL+ G
Sbjct: 507 LHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ AV + D +++LL G SP + A G++ A Q E + L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAW--NGYTPLHIAAKQNQVE---VARSL 621
Query: 338 LKYGAQIN 345
L+YG N
Sbjct: 622 LQYGGSAN 629
Score = 150 bits (379), Expect = 3e-36
Identities = 124/432 (28%), Positives = 209/432 (48%), Gaps = 54/432 (12%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL A++EG+VK++ +LL K ++ +G +H AA E ++ L+
Sbjct: 39 NTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
N ++ N K GF L++AA + H ++V+ LLE GA+ N T + TPL +A++ G
Sbjct: 99 NYGANVNAQSQK---GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 124 QIDVLRLLLQHGAN----VNGSH------------------------SMCGWNSLHQASF 155
+V+ L+ +G + H S G+ LH A+
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
EN + +LLL +GA+ GITPL +A++ G + + +L+ GA + + D+ TP
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 275
L AA+ GH + E+LL GA + + PIH AAQ H + LL+ D
Sbjct: 276 LHCAARNGHVRISEILLDHGA--PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 276 TGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVN 335
L+ ++P++ A GH ++LL G P+++A F +P+ +A +K+ ++
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF---TPLHIACKKN--HVRVME 388
Query: 336 ILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
+LLK GA I+ LH+A + + I + L++G S N E H + A
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH--LPIVKNLLQRGASPNVSNVKVETPLH-MAA 445
Query: 388 QAKYKEWLPHLL 399
+A + E +LL
Sbjct: 446 RAGHTEVAKYLL 457
Score = 145 bits (366), Expect = 9e-35
Identities = 91/295 (30%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR + + LL+ + DV G+ P+H AA++ ++ Q+L+N +S N+
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G LH+A+ +G+ +V++LL+ GA T +E TPL A NG + + +LL HG
Sbjct: 239 ---GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + + G + +H A+ ++ + ++LLL+ A + +TPL VAA G
Sbjct: 296 APIQAK-TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ GA N +AL+ TPL IA ++ H + +ELLL +GA D +S P+H A+
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT--ESGLTPLHVAS 412
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 310
MGH I+ L+ + + +P++ A GH + + LL+N +A+A
Sbjct: 413 FMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKA 467
Score = 144 bits (363), Expect = 2e-34
Identities = 108/332 (32%), Positives = 167/332 (50%), Gaps = 11/332 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G+ +V + LL+ V+ P+H AA +++L+ +++ N +
Sbjct: 443 MAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN---LA 499
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G LH+AA +GH + V LLE A T + TPL +A + G++ V LLL+
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + G LH A N +I+KLLL +G + G TPL +AA+ ++E
Sbjct: 560 AHPNAAGKN-GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVA 618
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
L+ G + N +++ TPL +AAQEGH + V LLLS A+ +L S P+H A
Sbjct: 619 RSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL--GNKSGLTPLHLVA 676
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFG 315
Q GH + D+LI T +P++ A G+ ++ LL+ + D A G
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ--HQADVNAKTKLG 734
Query: 316 FSSPVCMAFQKDCEFFGIVNILLKYGAQINEL 347
+ SP+ A Q+ IV +LLK GA NE+
Sbjct: 735 Y-SPLHQAAQQG--HTDIVTLLLKNGASPNEV 763
Score = 133 bits (335), Expect = 3e-31
Identities = 109/419 (26%), Positives = 187/419 (44%), Gaps = 55/419 (13%)
Query: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
AD ++ AAR GN+ L+ G ++ + G +H A+ V+ + L++
Sbjct: 10 ADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLH--- 66
Query: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDV 127
E ++ T +G ALH+AA G ++V+ L+ GA+ NA + + TPL++A + ++V
Sbjct: 67 KEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEV 126
Query: 128 LRLLLQHGANVN----------------------------GSHSMCGWNSLHQASFQENA 159
++ LL++GAN N G+ +LH A+ ++
Sbjct: 127 VKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDT 186
Query: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
+LL+ N + G TPL +AA Y L +L++ GA+VN + TPL IA
Sbjct: 187 RTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIA 246
Query: 220 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN 279
++ G+ V LLL GA + ++ P+H AA+ GH +I ++L+ N
Sbjct: 247 SRRGNVIMVRLLLDRGAQIETKTKDE--LTPLHCAARNGHVRISEILLDHGAPIQAKTKN 304
Query: 280 KVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLK 339
+SP++ A G H DC+ +LL+ D + +P+ +A C + +LL
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDD---ITLDHLTPLHVA--AHCGHHRVAKVLLD 359
Query: 340 YGAQINE--------LHLAYCLKYEKFSIFRYFLRKGCSLGPWN-------HIYEFVNH 383
GA+ N LH+A K + L+ G S+ H+ F+ H
Sbjct: 360 KGAKPNSRALNGFTPLHIA--CKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 132 bits (331), Expect = 1e-30
Identities = 79/257 (30%), Positives = 140/257 (54%), Gaps = 8/257 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G V+V LL++ + A G P+H A +HN+++ +++L+ S +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH---SP 598
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ G+ LH+AA Q ++ + LL+ G NA +++ TPL LA + G +++ LLL
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 136 ANVN-GSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 194
AN N G+ S G LH + + + + +L++ G + G TPL VA+ YG ++
Sbjct: 659 ANGNLGNKS--GLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
+ L+ A+VN + +PL AAQ+GHT V LLL +GA P+ ++ + P+ A
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT--TPLAIA 774
Query: 255 AQMGHTKILDLLIPLTN 271
++G+ + D+L +T+
Sbjct: 775 KRLGYISVTDVLKVVTD 791
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 150 bits (380), Expect = 2e-36
Identities = 110/368 (29%), Positives = 190/368 (51%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+ +V+ LL++G + G P+H AA + VEC++ L+ +
Sbjct: 277 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 336
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ + T + ALH+AA GH+++ ++LL+ A+PNA L TPL +A + +I V+
Sbjct: 337 VDDV---TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 393
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LL+++GA++ + G +H A+F + I+ LLL+ GA+ + + G T L +AA+
Sbjct: 394 ELLVKYGASIQAI-TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 452
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD--------- 239
G++E + L+ +GA V+ +A ++ TPL IA++ G T+ V+LLL A PD
Sbjct: 453 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 512
Query: 240 LYCNEDSWQL----------------------PIHAAAQMGHTKILDLLIPLTNRACDTG 277
L+ + Q+ P+H AA+ G + LL+ A G
Sbjct: 513 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 572
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ A ++ +LL G SP A A + +P+ +A +K+ I + L
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY---TPLHIAAKKN--QMQIASTL 627
Query: 338 LKYGAQIN 345
L YGA+ N
Sbjct: 628 LNYGAETN 635
Score = 147 bits (371), Expect = 2e-35
Identities = 107/333 (32%), Positives = 170/333 (51%), Gaps = 17/333 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G V+V+R LL+ G VD P+H A+ E +Q+L+ + +
Sbjct: 449 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD---AA 505
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G+ LH++A +G + +LLEAGA + T + TPL +A + G +DV +LLLQ
Sbjct: 506 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 565
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + S G LH A+ +N ++ LLL KGA+ G TPL +AA+ +++
Sbjct: 566 AAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 624
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
S L++ GA N TPL +A+QEGHT V LLL GA+ ++ + S +H AA
Sbjct: 625 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN--IHMSTKSGLTSLHLAA 682
Query: 256 QMGHTKILDLLIPLTNRACDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312
Q + D+L T D + +P+ A G+ + LL+ G + +A+
Sbjct: 683 QEDKVNVADIL---TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 739
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
+ +P+ A Q+ I+N+LL++GA+ N
Sbjct: 740 GY---TPLHQAAQQGHTH--IINVLLQHGAKPN 767
Score = 146 bits (369), Expect = 4e-35
Identities = 85/261 (32%), Positives = 142/261 (54%), Gaps = 6/261 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G++ V + LL++ + D A G P+H AA++++ + +L+ +S +
Sbjct: 548 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G+ LH+AA + +I LL GA+ N T + TPL LA + G D++ LLL G
Sbjct: 608 ---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
AN++ S + G SLH A+ ++ + +L + GA+++ G TPL VA YG ++ +
Sbjct: 665 ANIHMS-TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 723
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+ L+ GANVN + + TPL AAQ+GHT + +LL GA P+ + L I A
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI--AK 781
Query: 256 QMGHTKILDLLIPLTNRACDT 276
++G+ ++D L +T T
Sbjct: 782 RLGYISVVDTLKVVTEEVTTT 802
Score = 142 bits (359), Expect = 6e-34
Identities = 93/307 (30%), Positives = 166/307 (54%), Gaps = 23/307 (7%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL AA+EG+V ++++LL +G SVD A +G +H A+ E +++L+
Sbjct: 37 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
++ I ++ GF L++AA + H +V+ LLE GA+ + T + TPL +A++ G
Sbjct: 97 KEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD------- 176
+ +LL+ N + +LH A+ +++ + LLL+ N + Q
Sbjct: 154 HNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 208
Query: 177 -DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
+ G TPL +AA YG + ++L++ GA V+ A + TPL +A++ G+T V+LLL G
Sbjct: 209 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 236 ADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDC 295
D + P+H AA+ GH ++++LL+ N +SP++ A G H +C
Sbjct: 269 GQIDAKTRDG--LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326
Query: 296 LEILLRN 302
++ LL++
Sbjct: 327 VKHLLQH 333
Score = 140 bits (352), Expect = 4e-33
Identities = 105/340 (30%), Positives = 178/340 (52%), Gaps = 27/340 (7%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
+ +AA G++ ++ LL+ G S DV + RG +H AA VE ++ L+ + +
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA---LVD 470
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
+ E LH+A+ G +IVQ+LL+ A P+A T TPL ++ GQ+DV +LL+
Sbjct: 471 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530
Query: 134 HGANVNGSHSMC---GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
GA +HS+ G+ LH A+ + ++ KLLL++ A + G+TPL VAA Y
Sbjct: 531 AGA----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 586
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ +L+ GA+ + A + TPL IAA++ + LL+ GA+ ++ + P
Sbjct: 587 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV--TP 644
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL---EILLRNGYSPD 307
+H A+Q GHT ++ LL+ ++ + ++ S + S ED + +IL ++G D
Sbjct: 645 LHLASQEGHTDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 701
Query: 308 AQACLVFGFSSPVCMAFQKDCEFFGI--VNILLKYGAQIN 345
A L + +P+ +A C + + VN LLK GA +N
Sbjct: 702 AHTKLGY---TPLIVA----CHYGNVKMVNFLLKQGANVN 734
Score = 135 bits (340), Expect = 9e-32
Identities = 103/365 (28%), Positives = 178/365 (48%), Gaps = 23/365 (6%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+A ++ +KV+ L+K G S+ G PIH AA+ + + +L+ +S + ++
Sbjct: 383 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 442
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G ALH+AA G ++V+ LL GA +A EE TPL +A G+ ++++LLLQH
Sbjct: 443 ---GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ + + + G+ LH ++ + ++ +LL GA G TPL VAA+YG L+
Sbjct: 500 AHPDAATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ A + + TPL +AA + K LLL GA P + + P+H AA
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP--HATAKNGYTPLHIAA 616
Query: 256 QMGHTKILDLLIPLTNRACDTGL---NKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312
+ +I L+ N +T + V+P++ A GH D + +LL G +
Sbjct: 617 KKNQMQIASTLL---NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG--ANIHMST 671
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGA------QINELHLAYCLKYEKFSIFRYFLR 366
G +S + +A Q+D + +IL K+GA ++ L Y + + L+
Sbjct: 672 KSGLTS-LHLAAQED--KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 728
Query: 367 KGCSL 371
+G ++
Sbjct: 729 QGANV 733
Score = 98.2 bits (243), Expect = 2e-20
Identities = 76/262 (29%), Positives = 128/262 (48%), Gaps = 35/262 (13%)
Query: 61 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 120
ML +DS+ ++++ AA G+ V L+ G D N L LA
Sbjct: 4 MLQKSDSNASFLR------------AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAA 51
Query: 121 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
+ G + +++ LL G++V+ S + G +LH AS AE++K+L+++GAN Q G
Sbjct: 52 KEGHVGLVQELLGRGSSVD-SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF 110
Query: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
TPL++AAQ ++ + L+ +GAN + D TPL +A Q+GH + V +LL +
Sbjct: 111 TPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND----- 165
Query: 241 YCNEDSWQLP-IHAAAQMGHTKILDLLIP-----------LTNRACDTGLNKVSPVYSAV 288
+ +LP +H AA+ TK LL+ + NR ++G +P++ A
Sbjct: 166 --TKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAA 220
Query: 289 FGGHEDCLEILLRNGYSPDAQA 310
G+ + +LL G + D A
Sbjct: 221 HYGNVNVATLLLNRGAAVDFTA 242
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 150 bits (380), Expect = 2e-36
Identities = 110/368 (29%), Positives = 190/368 (51%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+ +V+ LL++G + G P+H AA + VEC++ L+ +
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ + T + ALH+AA GH+++ ++LL+ A+PNA L TPL +A + +I V+
Sbjct: 358 VDDV---TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LL+++GA++ + G +H A+F + I+ LLL+ GA+ + + G T L +AA+
Sbjct: 415 ELLVKYGASIQAI-TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD--------- 239
G++E + L+ +GA V+ +A ++ TPL IA++ G T+ V+LLL A PD
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 533
Query: 240 LYCNEDSWQL----------------------PIHAAAQMGHTKILDLLIPLTNRACDTG 277
L+ + Q+ P+H AA+ G + LL+ A G
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ A ++ +LL G SP A A + +P+ +A +K+ I + L
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY---TPLHIAAKKN--QMQIASTL 648
Query: 338 LKYGAQIN 345
L YGA+ N
Sbjct: 649 LNYGAETN 656
Score = 147 bits (371), Expect = 2e-35
Identities = 107/333 (32%), Positives = 170/333 (51%), Gaps = 17/333 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G V+V+R LL+ G VD P+H A+ E +Q+L+ + +
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD---AA 526
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G+ LH++A +G + +LLEAGA + T + TPL +A + G +DV +LLLQ
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + S G LH A+ +N ++ LLL KGA+ G TPL +AA+ +++
Sbjct: 587 AAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
S L++ GA N TPL +A+QEGHT V LLL GA+ ++ + S +H AA
Sbjct: 646 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN--IHMSTKSGLTSLHLAA 703
Query: 256 QMGHTKILDLLIPLTNRACDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312
Q + D+L T D + +P+ A G+ + LL+ G + +A+
Sbjct: 704 QEDKVNVADIL---TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
+ +P+ A Q+ I+N+LL++GA+ N
Sbjct: 761 GY---TPLHQAAQQGHTH--IINVLLQHGAKPN 788
Score = 146 bits (369), Expect = 4e-35
Identities = 85/261 (32%), Positives = 142/261 (54%), Gaps = 6/261 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G++ V + LL++ + D A G P+H AA++++ + +L+ +S +
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G+ LH+AA + +I LL GA+ N T + TPL LA + G D++ LLL G
Sbjct: 629 ---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
AN++ S + G SLH A+ ++ + +L + GA+++ G TPL VA YG ++ +
Sbjct: 686 ANIHMS-TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+ L+ GANVN + + TPL AAQ+GHT + +LL GA P+ + L I A
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI--AK 802
Query: 256 QMGHTKILDLLIPLTNRACDT 276
++G+ ++D L +T T
Sbjct: 803 RLGYISVVDTLKVVTEEVTTT 823
Score = 142 bits (359), Expect = 6e-34
Identities = 93/307 (30%), Positives = 166/307 (54%), Gaps = 23/307 (7%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL AA+EG+V ++++LL +G SVD A +G +H A+ E +++L+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
++ I ++ GF L++AA + H +V+ LLE GA+ + T + TPL +A++ G
Sbjct: 118 KEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD------- 176
+ +LL+ N + +LH A+ +++ + LLL+ N + Q
Sbjct: 175 HNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 229
Query: 177 -DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
+ G TPL +AA YG + ++L++ GA V+ A + TPL +A++ G+T V+LLL G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 236 ADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDC 295
D + P+H AA+ GH ++++LL+ N +SP++ A G H +C
Sbjct: 290 GQIDAKTRDG--LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
Query: 296 LEILLRN 302
++ LL++
Sbjct: 348 VKHLLQH 354
Score = 140 bits (352), Expect = 4e-33
Identities = 105/340 (30%), Positives = 178/340 (52%), Gaps = 27/340 (7%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
+ +AA G++ ++ LL+ G S DV + RG +H AA VE ++ L+ + +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA---LVD 491
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
+ E LH+A+ G +IVQ+LL+ A P+A T TPL ++ GQ+DV +LL+
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 134 HGANVNGSHSMC---GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
GA +HS+ G+ LH A+ + ++ KLLL++ A + G+TPL VAA Y
Sbjct: 552 AGA----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ +L+ GA+ + A + TPL IAA++ + LL+ GA+ ++ + P
Sbjct: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV--TP 665
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL---EILLRNGYSPD 307
+H A+Q GHT ++ LL+ ++ + ++ S + S ED + +IL ++G D
Sbjct: 666 LHLASQEGHTDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 308 AQACLVFGFSSPVCMAFQKDCEFFGI--VNILLKYGAQIN 345
A L + +P+ +A C + + VN LLK GA +N
Sbjct: 723 AHTKLGY---TPLIVA----CHYGNVKMVNFLLKQGANVN 755
Score = 135 bits (340), Expect = 9e-32
Identities = 103/365 (28%), Positives = 178/365 (48%), Gaps = 23/365 (6%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+A ++ +KV+ L+K G S+ G PIH AA+ + + +L+ +S + ++
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G ALH+AA G ++V+ LL GA +A EE TPL +A G+ ++++LLLQH
Sbjct: 464 ---GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ + + + G+ LH ++ + ++ +LL GA G TPL VAA+YG L+
Sbjct: 521 AHPDAATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ A + + TPL +AA + K LLL GA P + + P+H AA
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP--HATAKNGYTPLHIAA 637
Query: 256 QMGHTKILDLLIPLTNRACDTGL---NKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312
+ +I L+ N +T + V+P++ A GH D + +LL G +
Sbjct: 638 KKNQMQIASTLL---NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG--ANIHMST 692
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGA------QINELHLAYCLKYEKFSIFRYFLR 366
G +S + +A Q+D + +IL K+GA ++ L Y + + L+
Sbjct: 693 KSGLTS-LHLAAQED--KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Query: 367 KGCSL 371
+G ++
Sbjct: 750 QGANV 754
Score = 98.2 bits (243), Expect = 2e-20
Identities = 75/256 (29%), Positives = 125/256 (48%), Gaps = 23/256 (8%)
Query: 67 SSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQID 126
SS+ + K + + AA G+ V L+ G D N L LA + G +
Sbjct: 19 SSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVG 78
Query: 127 VLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVA 186
+++ LL G++V+ S + G +LH AS AE++K+L+++GAN Q G TPL++A
Sbjct: 79 LVQELLGRGSSVD-SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Query: 187 AQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDS 246
AQ ++ + L+ +GAN + D TPL +A Q+GH + V +LL + +
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND-------TKGK 190
Query: 247 WQLP-IHAAAQMGHTKILDLLIP-----------LTNRACDTGLNKVSPVYSAVFGGHED 294
+LP +H AA+ TK LL+ + NR ++G +P++ A G+ +
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVN 247
Query: 295 CLEILLRNGYSPDAQA 310
+LL G + D A
Sbjct: 248 VATLLLNRGAAVDFTA 263
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 150 bits (380), Expect = 2e-36
Identities = 110/368 (29%), Positives = 190/368 (51%), Gaps = 40/368 (10%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AAR G+ +V+ LL++G + G P+H AA + VEC++ L+ +
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP 357
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ + T + ALH+AA GH+++ ++LL+ A+PNA L TPL +A + +I V+
Sbjct: 358 VDDV---TLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LL+++GA++ + G +H A+F + I+ LLL+ GA+ + + G T L +AA+
Sbjct: 415 ELLVKYGASIQAI-TESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAAR 473
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD--------- 239
G++E + L+ +GA V+ +A ++ TPL IA++ G T+ V+LLL A PD
Sbjct: 474 AGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTP 533
Query: 240 LYCNEDSWQL----------------------PIHAAAQMGHTKILDLLIPLTNRACDTG 277
L+ + Q+ P+H AA+ G + LL+ A G
Sbjct: 534 LHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 593
Query: 278 LNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNIL 337
N ++P++ A ++ +LL G SP A A + +P+ +A +K+ I + L
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGY---TPLHIAAKKN--QMQIASTL 648
Query: 338 LKYGAQIN 345
L YGA+ N
Sbjct: 649 LNYGAETN 656
Score = 147 bits (371), Expect = 2e-35
Identities = 107/333 (32%), Positives = 170/333 (51%), Gaps = 17/333 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AAR G V+V+R LL+ G VD P+H A+ E +Q+L+ + +
Sbjct: 470 MAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPD---AA 526
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T G+ LH++A +G + +LLEAGA + T + TPL +A + G +DV +LLLQ
Sbjct: 527 TTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRR 586
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A + S G LH A+ +N ++ LLL KGA+ G TPL +AA+ +++
Sbjct: 587 AAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIA 645
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
S L++ GA N TPL +A+QEGHT V LLL GA+ ++ + S +H AA
Sbjct: 646 STLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN--IHMSTKSGLTSLHLAA 703
Query: 256 QMGHTKILDLLIPLTNRACDTGLNK---VSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312
Q + D+L T D + +P+ A G+ + LL+ G + +A+
Sbjct: 704 QEDKVNVADIL---TKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN 760
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
+ +P+ A Q+ I+N+LL++GA+ N
Sbjct: 761 GY---TPLHQAAQQGHTH--IINVLLQHGAKPN 788
Score = 146 bits (369), Expect = 4e-35
Identities = 85/261 (32%), Positives = 142/261 (54%), Gaps = 6/261 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G++ V + LL++ + D A G P+H AA++++ + +L+ +S +
Sbjct: 569 VAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G+ LH+AA + +I LL GA+ N T + TPL LA + G D++ LLL G
Sbjct: 629 ---GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
AN++ S + G SLH A+ ++ + +L + GA+++ G TPL VA YG ++ +
Sbjct: 686 ANIHMS-TKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+ L+ GANVN + + TPL AAQ+GHT + +LL GA P+ + L I A
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI--AK 802
Query: 256 QMGHTKILDLLIPLTNRACDT 276
++G+ ++D L +T T
Sbjct: 803 RLGYISVVDTLKVVTEEVTTT 823
Score = 142 bits (359), Expect = 6e-34
Identities = 93/307 (30%), Positives = 166/307 (54%), Gaps = 23/307 (7%)
Query: 9 DTCSTVGL-----AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
+TC+ GL AA+EG+V ++++LL +G SVD A +G +H A+ E +++L+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
++ I ++ GF L++AA + H +V+ LLE GA+ + T + TPL +A++ G
Sbjct: 118 KEGAN---INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD------- 176
+ +LL+ N + +LH A+ +++ + LLL+ N + Q
Sbjct: 175 HNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRT 229
Query: 177 -DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
+ G TPL +AA YG + ++L++ GA V+ A + TPL +A++ G+T V+LLL G
Sbjct: 230 TESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 236 ADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDC 295
D + P+H AA+ GH ++++LL+ N +SP++ A G H +C
Sbjct: 290 GQIDAKTRDG--LTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
Query: 296 LEILLRN 302
++ LL++
Sbjct: 348 VKHLLQH 354
Score = 140 bits (352), Expect = 4e-33
Identities = 105/340 (30%), Positives = 178/340 (52%), Gaps = 27/340 (7%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
+ +AA G++ ++ LL+ G S DV + RG +H AA VE ++ L+ + +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA---LVD 491
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
+ E LH+A+ G +IVQ+LL+ A P+A T TPL ++ GQ+DV +LL+
Sbjct: 492 ARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 551
Query: 134 HGANVNGSHSMC---GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
GA +HS+ G+ LH A+ + ++ KLLL++ A + G+TPL VAA Y
Sbjct: 552 AGA----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYD 607
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ +L+ GA+ + A + TPL IAA++ + LL+ GA+ ++ + P
Sbjct: 608 NQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGV--TP 665
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL---EILLRNGYSPD 307
+H A+Q GHT ++ LL+ ++ + ++ S + S ED + +IL ++G D
Sbjct: 666 LHLASQEGHTDMVTLLL---DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQD 722
Query: 308 AQACLVFGFSSPVCMAFQKDCEFFGI--VNILLKYGAQIN 345
A L + +P+ +A C + + VN LLK GA +N
Sbjct: 723 AHTKLGY---TPLIVA----CHYGNVKMVNFLLKQGANVN 755
Score = 135 bits (340), Expect = 9e-32
Identities = 103/365 (28%), Positives = 178/365 (48%), Gaps = 23/365 (6%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+A ++ +KV+ L+K G S+ G PIH AA+ + + +L+ +S + ++
Sbjct: 404 IACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIR 463
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G ALH+AA G ++V+ LL GA +A EE TPL +A G+ ++++LLLQH
Sbjct: 464 ---GETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ + + + G+ LH ++ + ++ +LL GA G TPL VAA+YG L+
Sbjct: 521 AHPDAATTN-GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L+ A + + TPL +AA + K LLL GA P + + P+H AA
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP--HATAKNGYTPLHIAA 637
Query: 256 QMGHTKILDLLIPLTNRACDTGL---NKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACL 312
+ +I L+ N +T + V+P++ A GH D + +LL G +
Sbjct: 638 KKNQMQIASTLL---NYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG--ANIHMST 692
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGA------QINELHLAYCLKYEKFSIFRYFLR 366
G +S + +A Q+D + +IL K+GA ++ L Y + + L+
Sbjct: 693 KSGLTS-LHLAAQED--KVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLK 749
Query: 367 KGCSL 371
+G ++
Sbjct: 750 QGANV 754
Score = 98.2 bits (243), Expect = 2e-20
Identities = 75/256 (29%), Positives = 125/256 (48%), Gaps = 23/256 (8%)
Query: 67 SSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQID 126
SS+ + K + + AA G+ V L+ G D N L LA + G +
Sbjct: 19 SSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVG 78
Query: 127 VLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVA 186
+++ LL G++V+ S + G +LH AS AE++K+L+++GAN Q G TPL++A
Sbjct: 79 LVQELLGRGSSVD-SATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137
Query: 187 AQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDS 246
AQ ++ + L+ +GAN + D TPL +A Q+GH + V +LL + +
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEND-------TKGK 190
Query: 247 WQLP-IHAAAQMGHTKILDLLIP-----------LTNRACDTGLNKVSPVYSAVFGGHED 294
+LP +H AA+ TK LL+ + NR ++G +P++ A G+ +
Sbjct: 191 VRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF---TPLHIAAHYGNVN 247
Query: 295 CLEILLRNGYSPDAQA 310
+LL G + D A
Sbjct: 248 VATLLLNRGAAVDFTA 263
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 146 bits (369), Expect = 4e-35
Identities = 99/364 (27%), Positives = 187/364 (51%), Gaps = 25/364 (6%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LA++EG+V+V+ +LL++ +VD A +G +H A+ E +++L+ ++ N +
Sbjct: 80 LASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVN---AQ 136
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ GF L++AA + H ++V+ LL+ GA + T + TPL +A++ G V+ LLL+
Sbjct: 137 SQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE-- 194
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
N + +LH A+ +++ + LLL+ N + + G TPL +AA YG +
Sbjct: 195 ---NDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
++L++ A V+ A + TPL +A++ G+ V+LLL GA D + P+H A
Sbjct: 252 TLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDG--LTPLHCGA 309
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFG 315
+ GH +++++L+ N +SP++ A G H +C+++LL++ D +
Sbjct: 310 RSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDD---VTND 366
Query: 316 FSSPVCMAFQKDCEFFGIVNILLKYGAQIN--------ELHLAYCLKYEKFSIFRYFLRK 367
+ + + +A C + + +LL A N LH+A K + + L+
Sbjct: 367 YLTALHVA--AHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA--CKKNRIKVMELLLKH 422
Query: 368 GCSL 371
G S+
Sbjct: 423 GASI 426
Score = 143 bits (360), Expect = 4e-34
Identities = 92/300 (30%), Positives = 153/300 (51%), Gaps = 6/300 (2%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AR G+ +V+ LL + + G P+H A + + C+Q+L+ +
Sbjct: 300 DGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVP 359
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ + T + ALH+AA GH+K+ ++LL+ A+PNA L TPL +A + +I V+
Sbjct: 360 VDDV---TNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVM 416
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+HGA++ + + G +H A+F + I+ L+ GA+ + G T L +AA+
Sbjct: 417 ELLLKHGASIQ-AVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAAR 475
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
G+ E + L+ GA V +A D TPL I+A+ G V+ LL GA P+ S
Sbjct: 476 SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN--AATTSGY 533
Query: 249 LPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 308
P+H +A+ GH + L+ T +P++ A G + +LL+ SPDA
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593
Score = 139 bits (350), Expect = 6e-33
Identities = 84/261 (32%), Positives = 139/261 (53%), Gaps = 6/261 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA+ G ++V LL+K S D A G P+H AA++++ + +L++ +S +
Sbjct: 571 VAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN 630
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G+ LH+AA + I LLE GAD NA T + + LA + G +D++ LLL
Sbjct: 631 ---GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRN 687
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
ANVN S+ G LH A+ ++ + ++L+ +GA+ + Q G TPL V YG ++ +
Sbjct: 688 ANVNLSNKS-GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIV 746
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+ L+ A VN + + TPL AAQ+GHT + +LL + A P+ + L I A
Sbjct: 747 NFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI--AR 804
Query: 256 QMGHTKILDLLIPLTNRACDT 276
++G+ ++D L +T T
Sbjct: 805 RLGYISVVDTLKIVTEETMTT 825
Score = 138 bits (348), Expect = 1e-32
Identities = 101/363 (27%), Positives = 169/363 (46%), Gaps = 44/363 (12%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+A ++ +KV+ LLK G S+ G PIH AA+ V + L++ +S N ++
Sbjct: 406 IACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVR 465
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G ALH+AA G ++V+ L++ GA A ++ TPL ++ G+ D+++ LLQ G
Sbjct: 466 ---GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQG 522
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + + G+ LH ++ + + ++ LL GA+ G TPL VAA+YGKLE
Sbjct: 523 ASPNAA-TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPI---- 251
++L+ A+ + TPL +AA + K LLL GA P L I
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKK 641
Query: 252 ---------------------------HAAAQMGHTKILDLLIPLTNRACDTGLNKVSPV 284
H AAQ GH ++ LL+ + + ++P+
Sbjct: 642 NQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPL 701
Query: 285 YSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEF--FGIVNILLKYGA 342
+ A + E+L+ G DAQ + + +P+ + C + IVN LL++ A
Sbjct: 702 HLAAQEDRVNVAEVLVNQGAHVDAQTKMGY---TPLHVG----CHYGNIKIVNFLLQHSA 754
Query: 343 QIN 345
++N
Sbjct: 755 KVN 757
Score = 135 bits (339), Expect = 1e-31
Identities = 87/299 (29%), Positives = 149/299 (49%), Gaps = 6/299 (2%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + ++AR G ++++LL++G S + A G+ P+H +A + L++ +S
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS 557
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+ + T +GF LH+AA G ++ +LL+ A P+A TPL +A V
Sbjct: 558 ---LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVA 614
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL GA+ + + + G+ LH A+ + +I LL GA+ GI + +AAQ
Sbjct: 615 LLLLDQGASPHAA-AKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQ 673
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
G ++ +S+L+ ANVN TPL +AAQE E+L++ GA D
Sbjct: 674 EGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD--AQTKMGY 731
Query: 249 LPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 307
P+H G+ KI++ L+ + + N +P++ A GH + +LL+N SP+
Sbjct: 732 TPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN 790
Score = 112 bits (279), Expect = 1e-24
Identities = 74/231 (32%), Positives = 127/231 (54%), Gaps = 7/231 (3%)
Query: 79 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 138
G ALHLA+ +GH ++V LL+ A+ +A T + T L +A GQ +V+++L+ +GANV
Sbjct: 74 GLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANV 133
Query: 139 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 198
N + S G+ L+ A+ + + E++K LL GA++ + G TPL VA Q G + +S+L
Sbjct: 134 N-AQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Query: 199 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMG 258
+ + + + + L IAA++ TK LLL + + D+ S P+H AA G
Sbjct: 193 LEN----DTKGKVRLPALHIAARKDDTKAAALLLQNDNNADV--ESKSGFTPLHIAAHYG 246
Query: 259 HTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 309
+ + LL+ T N ++P++ A G+ + +++LL G DA+
Sbjct: 247 NINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAK 297
Score = 89.0 bits (219), Expect = 1e-17
Identities = 61/208 (29%), Positives = 110/208 (52%), Gaps = 14/208 (6%)
Query: 103 ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEII 162
+D NA+ L A G ++ +++G ++N + G N+LH AS + + E++
Sbjct: 39 SDANASYLR-------AARAGHLEKALDYIKNGVDINICNQN-GLNALHLASKEGHVEVV 90
Query: 163 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 222
LL++ AN + G T L +A+ G+ E + +L+++GANVN Q+ + TPL++AAQE
Sbjct: 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 223 GHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVS 282
H + V+ LL +GA L ED + P+ A Q GH +++ LL+ + G ++
Sbjct: 151 NHLEVVKFLLDNGASQSL-ATEDGF-TPLAVALQQGHDQVVSLLLENDTK----GKVRLP 204
Query: 283 PVYSAVFGGHEDCLEILLRNGYSPDAQA 310
++ A +LL+N + D ++
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVES 232
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 142 bits (357), Expect = 1e-33
Identities = 103/303 (33%), Positives = 151/303 (49%), Gaps = 10/303 (3%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + AA+ G+ R LL G VD + GW P+H AA +N ++L++ +
Sbjct: 427 DGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQAD 486
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
N + EG LH+AA GH +V++L GA+ +A TPL LAVE G++ +
Sbjct: 487 PN---LHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
+ LL+ GA V + G+ LH A+ + I K+LLR GA+ E G TPL +AA
Sbjct: 544 QHLLKSGA-VPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAY 602
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
G LE + +L S AN+ TPL +AA+ G V LL GADP+ E S
Sbjct: 603 KGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPN--AAEQSGW 660
Query: 249 LPIHAAAQMGHTKILDLLIPLTNRACDTGLNKV--SPVYSAVFGGHEDCLEILLRNGYSP 306
P+H A Q + L ++ L + A NKV +P + A G+ L++L+ G
Sbjct: 661 TPLHLAVQ--RSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718
Query: 307 DAQ 309
D Q
Sbjct: 719 DVQ 721
Score = 115 bits (289), Expect = 7e-26
Identities = 92/324 (28%), Positives = 143/324 (44%), Gaps = 41/324 (12%)
Query: 46 PIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP 105
P+H SVE +++L+ + E + +T G+ L +AA + +LL GAD
Sbjct: 365 PLHFLVAQGSVEQVRLLL---AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADA 421
Query: 106 NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLL 165
N + PL A +NG RLLL HGA V+ GW LH A+ + +LL
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAAQNNFENVARLL 480
Query: 166 LRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 225
+ + A+ + G TPL VAA +G + + +L S GA ++ Q + TPL +A + G
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKV 540
Query: 226 KCVELLLSSGADPD-------------------LYC-------------NEDSWQLPIHA 253
+ ++ LL SGA PD L C W P+H
Sbjct: 541 RAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW-TPLHL 599
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 313
AA GH +I+ LL G +P++ A G E + LL+ G P+A
Sbjct: 600 AAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG 659
Query: 314 FGFSSPVCMAFQKDCEFFGIVNIL 337
+ +P+ +A Q+ F ++N+L
Sbjct: 660 W---TPLHLAVQRS-TFLSVINLL 679
Score = 107 bits (266), Expect = 3e-23
Identities = 69/204 (33%), Positives = 104/204 (50%), Gaps = 4/204 (1%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LA G V+ ++ LLK G D D G+ P+H AA +ML+ +S +++
Sbjct: 533 LAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS---LELP 589
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T +G+ LHLAA +GH +I+ +L E+ A+ A TPL LA +G+ V+ LLQ G
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCG 649
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A+ N + GW LH A + + LL AN ++ G TP +AA G L
Sbjct: 650 ADPNAA-EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708
Query: 196 SILISSGANVNCQALDKATPLFIA 219
+L+ +GA ++ Q TPL +A
Sbjct: 709 KVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 105 bits (261), Expect = 1e-22
Identities = 65/182 (35%), Positives = 97/182 (53%), Gaps = 4/182 (2%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA G + + LL+ G S+++ ++GW P+H AAY +E + +L A+S N +
Sbjct: 567 AAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLL--AESHANMGALGA 624
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
+ LHLAA G +V LL+ GADPNA TPL LAV+ + LL+H A
Sbjct: 625 VN-WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHA 683
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
NV+ + + GW H A+ + N I+K+L+ GA + QD TPL +A + K +S
Sbjct: 684 NVHARNKV-GWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMS 742
Query: 197 IL 198
L
Sbjct: 743 FL 744
Score = 96.7 bits (239), Expect = 5e-20
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 8/233 (3%)
Query: 112 ETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN 171
+ TPL V G ++ +RLLL H +V+ + G+ L A+ + ++ LLL GA+
Sbjct: 362 KVTPLHFLVAQGSVEQVRLLLAHEVDVD-CQTASGYTPLLIAAQDQQPDLCALLLAHGAD 420
Query: 172 KECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 231
D+ G PL AAQ G + +L+ GA V+ Q + TPL +AAQ LL
Sbjct: 421 ANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 232 LSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGG 291
+S ADP+L+ E + P+H AA GH ++ LL N +P++ AV G
Sbjct: 481 VSRQADPNLH--EAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG 538
Query: 292 HEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 344
++ LL++G PDA +G P+ A + + I +LL+YGA +
Sbjct: 539 KVRAIQHLLKSGAVPDALDQSGYG---PLHTAAARG--KYLICKMLLRYGASL 586
Score = 59.7 bits (143), Expect = 6e-09
Identities = 62/231 (26%), Positives = 95/231 (41%), Gaps = 46/231 (19%)
Query: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD 239
+TPL G +E + +L++ +V+CQ TPL IAAQ+ LLL+ GAD +
Sbjct: 363 VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADAN 422
Query: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLIP------------------------------L 269
+ED W P+H AAQ G LL+ L
Sbjct: 423 -RVDEDGW-APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Query: 270 TNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQK 326
+R D L++ +P++ A + GH +++L G DAQ +P+ +A ++
Sbjct: 481 VSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQ---RNLRTPLHLAVER 537
Query: 327 DCEFFGIVNILLKYGAQINELH------LAYCLKYEKFSIFRYFLRKGCSL 371
+ LLK GA + L L K+ I + LR G SL
Sbjct: 538 G--KVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL 586
Score = 36.2 bits (82), Expect = 0.074
Identities = 30/103 (29%), Positives = 44/103 (42%), Gaps = 2/103 (1%)
Query: 207 CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266
C +K TPL +G + V LLL+ D D C S P+ AAQ + LL
Sbjct: 357 CIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVD--CQTASGYTPLLIAAQDQQPDLCALL 414
Query: 267 IPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 309
+ A + +P++ A G + +LL +G DAQ
Sbjct: 415 LAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 139 bits (350), Expect = 6e-33
Identities = 125/419 (29%), Positives = 194/419 (46%), Gaps = 58/419 (13%)
Query: 130 LLLQHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 187
LL+ +GA+VN C +LH+A+ +++KL+L GA+ + Q +G TPL +AA
Sbjct: 4 LLINYGADVN---LRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAA 60
Query: 188 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSW 247
Q G E + +L+ GAN + QA D ++ L AA G+ V LLL GAD ++ N S
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKN--SG 118
Query: 248 QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG---- 303
LPIH AA GH L +LIP+T+ A + +SPV+ A G H CLE+L++ G
Sbjct: 119 HLPIHVAADRGHLLALKILIPVTDLAA-IKQSGISPVHCAAAGAHPQCLELLIQAGFDVN 177
Query: 304 ----------YSPDAQACLVFGFSS-------------------PV-CMAFQKDCEFFGI 333
Y ++ L F S+ PV C+ + +
Sbjct: 178 FMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYEL 237
Query: 334 VNILLKYGA------QINELHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKA 387
+++LL++GA ++N LH L+Y LR + G H K
Sbjct: 238 ISLLLRHGANVNYFCRVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTERCFDCPHGDKV 295
Query: 388 QAKY--KEWLPHLLV-AGFDPLILLCNSWIDSVSIDTLIFTLEFTNWKTLAPAVERMLSA 444
Y + W ++ F +I L SW+ +S + L++ + + ++ +L
Sbjct: 296 HPSYTVEGWTSTVIKDTKFCEVITL--SWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQK 353
Query: 445 RASNAWILQQHIATVP-SLTHLCRLEIRSSLKSERLRSDSYISQLPLPRSLHNYLLYED 502
+ W I T P SL HLCRL+IR + LR ++S LPLP L Y+LY++
Sbjct: 354 QG--IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKE 410
Score = 71.2 bits (173), Expect = 2e-12
Identities = 79/296 (26%), Positives = 144/296 (48%), Gaps = 27/296 (9%)
Query: 29 LLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAAS 88
L+ G V++ +HEAA + +++++ + + + ++ GF L LAA
Sbjct: 5 LINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPD---PQSTYGFTPLALAAQ 61
Query: 89 QGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWN 148
GH +I+++LL GA+ + + ++ L A G D + LLL++GA+ N + G
Sbjct: 62 SGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKN-SGHL 120
Query: 149 SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNC- 207
+H A+ + + +K+L+ + GI+P+ AA + L +LI +G +VN
Sbjct: 121 PIHVAADRGHLLALKILI-PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFM 179
Query: 208 --QALDK------ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 259
Q ++K + L+ A V+LLLS+GA P N+D + A +MG+
Sbjct: 180 LDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALP----NQDPVNC-LQIALRMGN 234
Query: 260 TKILDLLIPLTNRACDTGLNKVSPVY--SAVFGGHED--CLEILLRNGYSPDAQAC 311
+++ LL L + A +V+P++ SA+ +D L +LL GY D + C
Sbjct: 235 YELISLL--LRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGY--DTERC 286
Score = 65.1 bits (157), Expect = 1e-10
Identities = 72/277 (25%), Positives = 119/277 (42%), Gaps = 42/277 (15%)
Query: 6 AYADTCSTVG-----LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
A+ D ST G LAA+ G+ +++ LL+KG + + + EAA + + +
Sbjct: 43 AHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVA 102
Query: 61 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 120
+L+ + N K G +H+AA +GH ++IL+ D A +P+ A
Sbjct: 103 LLLEYGADANIPKN---SGHLPIHVAADRGHLLALKILIPV-TDLAAIKQSGISPVHCAA 158
Query: 121 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI 180
L LL+Q G +VN +L + NK DD
Sbjct: 159 AGAHPQCLELLIQAGFDVN------------------------FMLDQRINKH-YDDHRK 193
Query: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
+ L+ A L S+ +L+S+GA N D L IA + G+ + + LLL GA+ +
Sbjct: 194 SALYFAVSNSDLSSVKLLLSAGALPN---QDPVNCLQIALRMGNYELISLLLRHGANVNY 250
Query: 241 YCNEDSWQLPIHAAAQMGHT-KILDLLIPLTNRACDT 276
+C + P+H + + +T K +L L N DT
Sbjct: 251 FCRVN----PLHFPSALQYTLKDEVMLRMLLNYGYDT 283
Score = 57.0 bits (136), Expect = 4e-08
Identities = 37/108 (34%), Positives = 58/108 (53%), Gaps = 2/108 (1%)
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
++LI+ GA+VN + ++ T L AA+ G V+L+L SGA PD P+ AA
Sbjct: 3 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGF--TPLALAA 60
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 303
Q GHT+I+++L+ A + S + A GG+ D + +LL G
Sbjct: 61 QSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYG 108
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 128 bits (322), Expect = 1e-29
Identities = 96/332 (28%), Positives = 161/332 (48%), Gaps = 12/332 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA VK L+ +V+V+D G +H AA+ E +++L++ ++ N K
Sbjct: 113 IAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKK 172
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
A+H AA GH ++V++L+ GA+ + TPL A +G I V++ LL G
Sbjct: 173 DRR---AIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLG 229
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL-FVAAQYGKLES 194
++N ++ G LH A + ++ L+ GA +++ G TPL F AA
Sbjct: 230 VDMNEPNAY-GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALC 288
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
L +L+ +GA+VN ++ D TPL + A G + ++ SGA D C + + P+H A
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVID--CEDKNGNTPLHIA 346
Query: 255 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVF 314
A+ GH +++ LI G++ + P++ A G DC LL +G+ D F
Sbjct: 347 ARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPD--DF 404
Query: 315 GFSSPVCMAFQKDCEFFGIVNILLKYGAQINE 346
G + A + E +N+LL GA N+
Sbjct: 405 GRTCLHAAAAGGNLE---CLNLLLNTGADFNK 433
Score = 119 bits (299), Expect = 5e-27
Identities = 93/290 (32%), Positives = 138/290 (47%), Gaps = 19/290 (6%)
Query: 21 GNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGF 80
G+ +R L+ K V+ DN P+H AAY E +++LI + + N K +
Sbjct: 19 GDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN---AKDSKWL 75
Query: 81 CALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNG 140
LH A + + VQ+LL+ AD NA TPL +A N + L+ +NVN
Sbjct: 76 TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135
Query: 141 SHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS 200
S G +LH A+F + E++KLLL +GAN D + AA G +E + +L+S
Sbjct: 136 S-DRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
Query: 201 SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD---PDLYCNEDSWQLPIHAAAQM 257
GA V C+ TPL AA G V+ LL G D P+ Y N P+H A
Sbjct: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN-----TPLHVACYN 249
Query: 258 GHTKILDLLI---PLTNRACDTGLNKVSPVYSAVFGGHED-CLEILLRNG 303
G +++ LI + N+ + G +P++ A H CLE+L+ NG
Sbjct: 250 GQDVVVNELIDCGAIVNQKNEKGF---TPLHFAAASTHGALCLELLVGNG 296
Score = 116 bits (290), Expect = 6e-26
Identities = 91/303 (30%), Positives = 147/303 (48%), Gaps = 21/303 (6%)
Query: 10 TCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS- 68
T S + LAA G+ + L L++ +DV ++ G P+ AA+ VEC+ +LIN +S
Sbjct: 550 TISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASI 609
Query: 69 --ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE---TTPLFLAVENG 123
++YI +T +H AA+ GH + +++L+ NA +++ TPL L+V NG
Sbjct: 610 LVKDYILKRT-----PIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNG 664
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
D + LL GANV+ G +LH+ + + E + LL+ GA +D G TP+
Sbjct: 665 HTDCVYSLLNKGANVDAKDKW-GRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPI 723
Query: 184 FVAAQYGKLESLSILISSGANVNCQALDK----ATPLFIAAQEGHTKCVELLLSSGADPD 239
++A G + L L+ S A+++ T L A GH CVELLL
Sbjct: 724 HLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQK 783
Query: 240 LYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC--DTGLNKVSPVYSAVFGGHEDCLE 297
N S P+H A + ++LI + T +P+++A F H +CL+
Sbjct: 784 TEGNAFS---PLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ 840
Query: 298 ILL 300
+LL
Sbjct: 841 LLL 843
Score = 115 bits (287), Expect = 1e-25
Identities = 95/327 (29%), Positives = 153/327 (46%), Gaps = 48/327 (14%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA G+ ++++ LL +G +++ D + IH AAY +E +++L++ + + K
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE---VTCKD 203
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
+ + LH AAS G +V+ LL+ G D N TPL +A NGQ V+ L+ GA
Sbjct: 204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGA 263
Query: 137 NVNGSH----------------SMC-----------------GWNSLHQASFQENAEIIK 163
VN + ++C G LH + +
Sbjct: 264 IVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQ 323
Query: 164 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 223
+++ GA +C+D G TPL +AA+YG ++ LI+SGA+ + + PL +AA G
Sbjct: 324 TIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSG 383
Query: 224 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKV-- 281
+ C LLSSG D D +D + +HAAA G+ + L+LL+ N D NK
Sbjct: 384 FSDCCRKLLSSGFDID--TPDDFGRTCLHAAAAGGNLECLNLLL---NTGAD--FNKKDK 436
Query: 282 ---SPVYSAVFGGHEDCLEILLRNGYS 305
SP++ A + CL L+ +G S
Sbjct: 437 FGRSPLHYAAANCNYQCLFALVGSGAS 463
Score = 113 bits (282), Expect = 5e-25
Identities = 94/311 (30%), Positives = 152/311 (48%), Gaps = 23/311 (7%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LAA G RKLL G +D D+ G +H AA ++ECL +L+N + N K
Sbjct: 378 LAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN---KK 434
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPL-FLAVENGQIDVLRLLLQH 134
G LH AA+ +++ + L+ +GA N TPL + A + L LL++
Sbjct: 435 DKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRN 494
Query: 135 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFG------------ITP 182
AN G G+N++H ++ + ++L+ + + G I+P
Sbjct: 495 DANP-GIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISP 553
Query: 183 LFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYC 242
L +AA +G ++L +L+ S +++ + TPL +AA +GH +CV++L++ GA L
Sbjct: 554 LHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS-ILVK 612
Query: 243 NEDSWQLPIHAAAQMGHTKILDLLI----PLTNRACDTGLNKVSPVYSAVFGGHEDCLEI 298
+ + PIHAAA GH++ L LLI P G N +P+ +V GH DC+
Sbjct: 613 DYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDG-NGQTPLMLSVLNGHTDCVYS 671
Query: 299 LLRNGYSPDAQ 309
LL G + DA+
Sbjct: 672 LLNKGANVDAK 682
Score = 99.0 bits (245), Expect = 9e-21
Identities = 89/315 (28%), Positives = 152/315 (48%), Gaps = 25/315 (7%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNS-VECLQMLINADSSEN 70
S + AA N + L L+ G SV+ D RG P+H AA ++ +CL+ L+ D++
Sbjct: 440 SPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPG 499
Query: 71 YIKMKTFEGFCALHLAASQGHWKIVQILLE----------AGADPNATTLEETT--PLFL 118
++ +G+ A+H +A+ GH +Q++ +G D + + T PL L
Sbjct: 500 ---IRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHL 556
Query: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD-D 177
A +G L +L+Q +++ +S G L A+F+ + E + +L+ +GA+ +D
Sbjct: 557 AAYHGHHQALEVLVQSLLDLDVRNS-SGRTPLDLAAFKGHVECVDVLINQGASILVKDYI 615
Query: 178 FGITPLFVAAQYGKLESLSILISSGA---NVNCQALDKATPLFIAAQEGHTKCVELLLSS 234
TP+ AA G E L +LI + V+ Q + TPL ++ GHT CV LL+
Sbjct: 616 LKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675
Query: 235 GADPDLYCNEDSW-QLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHE 293
GA+ D +D W + +H A GH + +D L+ + +P++ + GH
Sbjct: 676 GANVDA---KDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHI 732
Query: 294 DCLEILLRNGYSPDA 308
L LL++ S DA
Sbjct: 733 GVLGALLQSAASMDA 747
Score = 98.6 bits (244), Expect = 1e-20
Identities = 96/348 (27%), Positives = 149/348 (42%), Gaps = 58/348 (16%)
Query: 17 AAREGNVKVLRKLLKKGR---SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK 73
AA G+ + LR L+ +VD+ D G P+ + + +C+ L+N ++ +
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGAN---VD 680
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
K G ALH A GH + V LL+ GA TP+ L+ G I VL LLQ
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 740
Query: 134 HGANVNGSHSMC---GWNSLHQASFQENAEIIKLLLRKGANKECQ--------------- 175
A+++ + + G+ +LH A + + ++LLL + ++ +
Sbjct: 741 SAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDN 800
Query: 176 -------------------DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPL 216
D G TPL AA +E L +L+S A VN TPL
Sbjct: 801 EGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPL 860
Query: 217 FIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH-TKILDLLIPLTNRACD 275
+AA+ G T VE+L+SS A +L ++S +H A GH T L +L +T+R
Sbjct: 861 MMAAENGQTNTVEMLVSS-ASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLI 919
Query: 276 TGLNKV--SPVYSAVFGGHEDCLEILL----------RNGYSPDAQAC 311
N +P++ A G ++ LL NGY+P A AC
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP-ALAC 966
Score = 75.9 bits (185), Expect = 8e-14
Identities = 55/196 (28%), Positives = 93/196 (47%), Gaps = 7/196 (3%)
Query: 149 SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQ 208
SL QA F + + ++ L+ K + QD+ TPL AA G E + +LI SGA VN +
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 209 ALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIP 268
TPL A + V++LL A D+ + +WQ P+H AA K + L+P
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSA--DVNARDKNWQTPLHIAAANKAVKCAEALVP 128
Query: 269 LTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC 328
L + + + ++ A F GH + +++LL G + +A F + +
Sbjct: 129 LLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINA-----FDKKDRRAIHWAAYM 183
Query: 329 EFFGIVNILLKYGAQI 344
+V +L+ +GA++
Sbjct: 184 GHIEVVKLLVSHGAEV 199
Score = 63.9 bits (154), Expect = 3e-10
Identities = 64/260 (24%), Positives = 109/260 (41%), Gaps = 39/260 (15%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVDV----ADNRGWMPIHEAAYHNSVECLQMLI------ 63
+ L+A G++ VL LL+ S+D ADN G+ +H A Y+ C+++L+
Sbjct: 723 IHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQ 782
Query: 64 -----------------NADSSE--------NYIKMKTFEGFCALHLAASQGHWKIVQIL 98
N ++E + + +G LH AA H + +Q+L
Sbjct: 783 KTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLL 842
Query: 99 LEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQEN 158
L A N+ TPL +A ENGQ + + +L+ + +LH A + +
Sbjct: 843 LSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGH 902
Query: 159 AEIIKLLLRKGANKECQDDFGI---TPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
L+L K ++ + TPL VAA+ G + L+ GA+V + TP
Sbjct: 903 ETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTP 962
Query: 216 -LFIAAQEGHTKCVELLLSS 234
L A + C+ L+L++
Sbjct: 963 ALACAPNKDVADCLALILAT 982
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 128 bits (322), Expect = 1e-29
Identities = 93/307 (30%), Positives = 151/307 (49%), Gaps = 18/307 (5%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
+ + +A+ +GNV+V+R LL +G + D+ GW P+H AA+ + LI + N
Sbjct: 816 TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE 875
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
I +G LA+ +GH+ VQILLE ++ + + L +A G D++ LL
Sbjct: 876 IDN---DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Query: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
HGA+VN G +L+ + + + + L GAN E D G T L V+ G
Sbjct: 933 FSHGADVN-CKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGH 991
Query: 192 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPI 251
+E + +LI+ A+VN +K + L AA +GH K V+LL+ GA D CN+ + L I
Sbjct: 992 MEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCI 1051
Query: 252 HAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQAC 311
AAQ GH ++ +L+ + P ++ FG + + +NG+S +
Sbjct: 1052 --AAQEGHIDVVQVLLE----------HGADPNHADQFG--RTAMRVAAKNGHSQIIKLL 1097
Query: 312 LVFGFSS 318
+G SS
Sbjct: 1098 EKYGASS 1104
Score = 125 bits (313), Expect = 1e-28
Identities = 99/359 (27%), Positives = 163/359 (45%), Gaps = 40/359 (11%)
Query: 18 AREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTF 77
A +G+ V+ L+ +G VD D G P+ AAY V+ + +L+ + ++
Sbjct: 723 ASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN-- 780
Query: 78 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 137
G L AAS GH +V LL GA ++ E T L +A G ++V+R LL G +
Sbjct: 781 -GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLD 839
Query: 138 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 197
N GW LH A+F+ + I + L+ +GA D+ G P +A+Q G + + I
Sbjct: 840 ENHRDD-AGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQI 898
Query: 198 LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGAD---------PDLY------- 241
L+ + +N++ + D L +AA EGH VELL S GAD P LY
Sbjct: 899 LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 242 ---------------CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYS 286
++ + +H + GH +++ +LI K S + S
Sbjct: 959 LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018
Query: 287 AVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
A + GH +++L+ +G D C ++ +C+A Q+ +V +LL++GA N
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVD-HTC--NQGATALCIAAQEG--HIDVVQVLLEHGADPN 1072
Score = 123 bits (308), Expect = 5e-28
Identities = 116/413 (28%), Positives = 177/413 (42%), Gaps = 53/413 (12%)
Query: 1 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQ 60
++ +A+ T T LAAR+G+ KV+ L+ G +++ D GW + AA+ E +
Sbjct: 571 LEIEDAHGHTPLT--LAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVS 628
Query: 61 MLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV 120
L+ A + + AL AA GH IV LL+ GA+ N E T L A
Sbjct: 629 ALLYAGVK---VDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAA 685
Query: 121 ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASF-----QENAEIIKLLLRKGANKECQ 175
G +++ LL HGA VN + G +L A+ + +A ++ LL+ +GA +
Sbjct: 686 YMGHREIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
Query: 176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
D G+TPL VAA G ++ + +L+ GA+V+ + TPL AA GH V LL G
Sbjct: 745 DKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWG 804
Query: 236 ADPDLYCNE-------------------------------DSWQLPIHAAAQMGHTKILD 264
A D +E D+ P+H AA GH I +
Sbjct: 805 AAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICE 864
Query: 265 LLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAF 324
LI R + + P A GH DC++ILL N + D + G+ +
Sbjct: 865 ALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR-----GYDGRNALRV 919
Query: 325 QKDCEFFGIVNILLKYGAQIN-----ELHLAYCLKYE-KFSIFRYFLRKGCSL 371
IV +L +GA +N Y L E + ++ YFL G ++
Sbjct: 920 AALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANV 972
Score = 101 bits (251), Expect = 2e-21
Identities = 83/287 (28%), Positives = 129/287 (44%), Gaps = 9/287 (3%)
Query: 24 KVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCAL 83
+VL+ L+K G V+ D+R + +A + ++ L++ +S N G L
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSN---GRTLL 549
Query: 84 HLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHS 143
AA G +V +L+ GAD TPL LA G V+ L+ GAN+N +
Sbjct: 550 ANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHT-D 608
Query: 144 MCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGA 203
GW +L A++ + E++ LL G +C D T L AA G + + L+ GA
Sbjct: 609 QDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGA 668
Query: 204 NVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA---AAQMGHT 260
VN + T L AA GH + VE LL GA+ + + L + A A GH
Sbjct: 669 EVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHA 728
Query: 261 KILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 307
++ LLI + ++P+ A + GH D +++LL G D
Sbjct: 729 SVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVD 775
Score = 65.5 bits (158), Expect = 1e-10
Identities = 42/149 (28%), Positives = 79/149 (53%), Gaps = 3/149 (2%)
Query: 20 EGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEG 79
+G++++++ L+ V+ ADN + AA+ V+ +Q+LI + ++ +G
Sbjct: 989 QGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHT---CNQG 1045
Query: 80 FCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVN 139
AL +AA +GH +VQ+LLE GADPN T + +A +NG +++LL ++GA+
Sbjct: 1046 ATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSL 1105
Query: 140 GSHSMCGWNSLHQASFQENAEIIKLLLRK 168
S +++ Q Q + ++ L K
Sbjct: 1106 NGCSPSPVHTMEQKPLQSLSSKVQSLTIK 1134
Score = 44.7 bits (104), Expect = 2e-04
Identities = 30/102 (29%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 2 DFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQM 61
D A + S + AA +G+VKV++ L++ G VD N+G + AA ++ +Q+
Sbjct: 1004 DVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQV 1063
Query: 62 LINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGA 103
L+ + N+ G A+ +AA GH +I+++L + GA
Sbjct: 1064 LLEHGADPNHADQ---FGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 [Homo
sapiens]
Length = 2542
Score = 125 bits (313), Expect = 1e-28
Identities = 93/291 (31%), Positives = 146/291 (50%), Gaps = 10/291 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGW-MPIHEAAYHNSVECLQMLINADSSENYIKM 74
LAA G+V V+ LL KG ++ R P+ A E + +L+ +++ +
Sbjct: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH--- 1150
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--TTPLFLAVENGQIDVLRLLL 132
+ + L LAAS G+ I++ILL AGA+ N+ T + +PL LA NG + ++LLL
Sbjct: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Query: 133 QHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKL 192
G+++N +L A FQ AE++ LLL + AN E + G+TPL AA G
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 193 ESLSILISSGANVNCQAL--DKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
E +L+ GA+VN + + T L IAA +GH K ELL+ GA D+ P
Sbjct: 1271 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV--RNKKGNTP 1328
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
+ A+ GH ++ LL+ K++P+ SA GH ++ L++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 119 bits (297), Expect = 9e-27
Identities = 108/355 (30%), Positives = 158/355 (44%), Gaps = 70/355 (19%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A G V +++ LL +G +++ + G P+ EAA VE ++L++ + N +
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
E AL LA +GH +V+ LLEAGAD T E T L A +G ++V RLLL GA
Sbjct: 372 KES--ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
VN + L A+ + E+ LL+ +GAN E +D G TPL AA+ G E ++
Sbjct: 430 QVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 197 ILISSGANVNCQA-------------------------------LDKATPLFIAAQEGHT 225
+L++ GAN+N Q L +TPL A+QEGH
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHL 548
Query: 226 KCVELLLSSGAD-------------------------------PDLYCNEDSWQLPIHAA 254
+ V+ LL+SGA+ DL + + P+ A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
Query: 255 AQMGHTKILDLLIPL---TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSP 306
A+ GH + LI NRA T N + V A GGH +E+LL +G P
Sbjct: 609 ARAGHLCTVQFLISKGANVNRA--TANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Score = 110 bits (274), Expect = 4e-24
Identities = 97/345 (28%), Positives = 164/345 (47%), Gaps = 23/345 (6%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
T + A+ CS +G+V +RKLL +GRSV+ G + A E Q+L+
Sbjct: 206 TRSLAEACS-------DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
Query: 64 NADSSENYIKMKTFEG-FCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVEN 122
++ ++ + +G L A+S G+ IV++LL AD N+ + T L A
Sbjct: 259 AMHAN---VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAG 315
Query: 123 GQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGIT 181
G +D++++LL GAN+ H+ G L +A+ + E+ ++LL GA ++F +
Sbjct: 316 GFVDIVKVLLNEGANIE-DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
Query: 182 PLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 241
L +A G L+ + L+ +GA+ + + T L A +GH + LLL SGA ++
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM- 433
Query: 242 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
DS++ P+ AA GH ++ LLI + +P+ A GHE+ + +LL
Sbjct: 434 -PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 302 NGYSPDAQA--CLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 344
G + +AQ + C F + +F L+K GA I
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADF------LIKAGADI 531
Score = 108 bits (269), Expect = 2e-23
Identities = 95/336 (28%), Positives = 163/336 (48%), Gaps = 15/336 (4%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWM-PIHEAAYHNSVECLQMLINADSSEN 70
S + LA G ++ + LL +V+ N+G + P+ A+ ++ +++L+ D+ N
Sbjct: 240 SLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN 299
Query: 71 YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130
++ G AL A + G IV++LL GA+ TPL A G ++V R+
Sbjct: 300 ---SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
LL HGA +N + ++L A ++ + ++++ LL GA++E + D T L A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+E +L+ SGA VN A +PL +AA GH + LL+ GA +L D P
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--NLEEVNDEGYTP 474
Query: 251 IHAAAQMGHTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 309
+ AA+ GH +++ LL+ N T + + + A GG + + L++ G
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------ 528
Query: 310 ACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
A + G S+P+ A Q+ +V LL GA ++
Sbjct: 529 ADIELGCSTPLMEASQEG--HLELVKYLLASGANVH 562
Score = 99.0 bits (245), Expect = 9e-21
Identities = 85/286 (29%), Positives = 139/286 (48%), Gaps = 11/286 (3%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A +G+V+V R LL G V++ + P+ AA VE +LI ++ ++
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN---LEEVN 468
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHG 135
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G +V L++ G
Sbjct: 469 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 528
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A++ S L +AS + + E++K LL GAN G T L A + G +
Sbjct: 529 ADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD-LYCNEDSWQLPIHAA 254
+L+ +GA++ ++ TPL AA+ GH V+ L+S GA+ + N D + + A
Sbjct: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
Query: 255 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
GH +++LL+ + + + A GGH + + LL
Sbjct: 645 G--GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 97.8 bits (242), Expect = 2e-20
Identities = 73/266 (27%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 82 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 141
AL LA + GH ++V +L+ A + TPL LA G + V+ +LL G ++
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 142 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 201
L A E++ LLL +GANKE ++ TPL +AA G + + IL+++
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 202 GANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 259
GA +N + K +PL +AA GH V+LLL G+D + E + + A G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI-ETNRNTALTLACFQGR 1236
Query: 260 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSP 319
+++ LL+ ++P+ A GG+ + +LL G +A S
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP---VPSSRD 1293
Query: 320 VCMAFQKDCEFFGIVNILLKYGAQIN 345
+ D + +L+ GA I+
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHID 1319
Score = 96.7 bits (239), Expect = 5e-20
Identities = 86/289 (29%), Positives = 131/289 (45%), Gaps = 41/289 (14%)
Query: 57 ECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNA-TTLEETTP 115
E + +LI D+ I+ + +GF L LAA+ GH +V+ILL+ G D A + + TP
Sbjct: 1069 ELVSVLIARDAK---IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 116 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGA--NKE 173
L LA G+ +V+ LLL GAN ++ + L A+ IIK+LL GA N
Sbjct: 1126 LSLACSGGRQEVVDLLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
Query: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQ-----------------------AL 210
GI+PL +AA G + ++ +L+ G+++N Q L
Sbjct: 1185 TGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLL 1244
Query: 211 DK-----------ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 259
D+ TPL AA G+ + +LL GAD + S + AA GH
Sbjct: 1245 DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGH 1304
Query: 260 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 308
K +LLI +P++ A GGH D +++L++ G DA
Sbjct: 1305 YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/222 (29%), Positives = 117/222 (52%), Gaps = 5/222 (2%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVD--VADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
+ LAA G V +++ LL G ++ G P+ AA + V +++L++ S N
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN- 1217
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
+++T AL LA QG ++V +LL+ A+ TPL A G +V R+L
Sbjct: 1218 AQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
Query: 132 LQHGANVNGSHSMCGWNS-LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
L GA+VN ++ L A+ + + + +LL+ +GA+ + ++ G TPL++A+ G
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
+ + +L+ +GA+V+ K TPL A ++GH K V+ L+
Sbjct: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 73.6 bits (179), Expect = 4e-13
Identities = 75/268 (27%), Positives = 120/268 (44%), Gaps = 16/268 (5%)
Query: 86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 145
A S G V+ LL+ G N T E + L LA G ++ ++LL ANV +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
L AS +I+KLLL A+ Q G T L A G ++ + +L++ GAN+
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 206 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 265
+ TPL AA GH + +LL GA + + NE + + A GH LD+
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGH---LDM 387
Query: 266 LIPLTNRACDTGLNKVSPVYSAV----FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 321
+ L D +K +++A+ GH + +LL +G + A F SP+
Sbjct: 388 VRFLLEAGADQE-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLT 443
Query: 322 MAFQKDC-EFFGIVNILLKYGAQINELH 348
+A C + +L++ GA + E++
Sbjct: 444 LA---ACGGHVELAALLIERGANLEEVN 468
Score = 63.5 bits (153), Expect = 4e-10
Identities = 56/202 (27%), Positives = 93/202 (46%), Gaps = 8/202 (3%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
TE +T T LA G +V L+K G +++ + P+ EA+ +E ++ L+
Sbjct: 501 TEETQETALT--LACCGGFSEVADFLIKAGADIELGCST---PLMEASQEGHLELVKYLL 555
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
+ ++ + T G AL A GH + +LL+AGAD + TPL A G
Sbjct: 556 ASGAN---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 612
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
+ ++ L+ GANVN + + + A + +++LLL GA+ + G T L
Sbjct: 613 HLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 672
Query: 184 FVAAQYGKLESLSILISSGANV 205
AA+ G +S L+ NV
Sbjct: 673 IEAAKGGHTNVVSYLLDYPNNV 694
Score = 59.7 bits (143), Expect = 6e-09
Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 4/165 (2%)
Query: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
T L +A G E +S+LI+ A + + TPL +AA GH VE+LL G D +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
+E + P+ A G +++DLL+ ++ +P+ A GG+ + ++ILL
Sbjct: 1117 Q-SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 301 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
G +++ G SP+ +A V +LL G+ IN
Sbjct: 1176 NAGAEINSRTGSKLGI-SPLMLAAMNG--HVPAVKLLLDMGSDIN 1217
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 125 bits (313), Expect = 1e-28
Identities = 93/291 (31%), Positives = 146/291 (50%), Gaps = 10/291 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGW-MPIHEAAYHNSVECLQMLINADSSENYIKM 74
LAA G+V V+ LL KG ++ R P+ A E + +L+ +++ +
Sbjct: 1094 LAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEH--- 1150
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEE--TTPLFLAVENGQIDVLRLLL 132
+ + L LAAS G+ I++ILL AGA+ N+ T + +PL LA NG + ++LLL
Sbjct: 1151 RNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLL 1210
Query: 133 QHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKL 192
G+++N +L A FQ AE++ LLL + AN E + G+TPL AA G
Sbjct: 1211 DMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYA 1270
Query: 193 ESLSILISSGANVNCQAL--DKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
E +L+ GA+VN + + T L IAA +GH K ELL+ GA D+ P
Sbjct: 1271 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV--RNKKGNTP 1328
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
+ A+ GH ++ LL+ K++P+ SA GH ++ L++
Sbjct: 1329 LWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 119 bits (297), Expect = 9e-27
Identities = 108/355 (30%), Positives = 158/355 (44%), Gaps = 70/355 (19%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A G V +++ LL +G +++ + G P+ EAA VE ++L++ + N +
Sbjct: 312 ACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEF 371
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
E AL LA +GH +V+ LLEAGAD T E T L A +G ++V RLLL GA
Sbjct: 372 KES--ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 429
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
VN + L A+ + E+ LL+ +GAN E +D G TPL AA+ G E ++
Sbjct: 430 QVNMPADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 197 ILISSGANVNCQA-------------------------------LDKATPLFIAAQEGHT 225
+L++ GAN+N Q L +TPL A+QEGH
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHL 548
Query: 226 KCVELLLSSGAD-------------------------------PDLYCNEDSWQLPIHAA 254
+ V+ LL+SGA+ DL + + P+ A
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 608
Query: 255 AQMGHTKILDLLIPL---TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSP 306
A+ GH + LI NRA T N + V A GGH +E+LL +G P
Sbjct: 609 ARAGHLCTVQFLISKGANVNRA--TANNDHTVVSLACAGGHLAVVELLLAHGADP 661
Score = 110 bits (274), Expect = 4e-24
Identities = 97/345 (28%), Positives = 164/345 (47%), Gaps = 23/345 (6%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
T + A+ CS +G+V +RKLL +GRSV+ G + A E Q+L+
Sbjct: 206 TRSLAEACS-------DGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLL 258
Query: 64 NADSSENYIKMKTFEG-FCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVEN 122
++ ++ + +G L A+S G+ IV++LL AD N+ + T L A
Sbjct: 259 AMHAN---VEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAG 315
Query: 123 GQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGIT 181
G +D++++LL GAN+ H+ G L +A+ + E+ ++LL GA ++F +
Sbjct: 316 GFVDIVKVLLNEGANIE-DHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKES 374
Query: 182 PLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 241
L +A G L+ + L+ +GA+ + + T L A +GH + LLL SGA ++
Sbjct: 375 ALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM- 433
Query: 242 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
DS++ P+ AA GH ++ LLI + +P+ A GHE+ + +LL
Sbjct: 434 -PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLA 492
Query: 302 NGYSPDAQA--CLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 344
G + +AQ + C F + +F L+K GA I
Sbjct: 493 QGANINAQTEETQETALTLACCGGFSEVADF------LIKAGADI 531
Score = 108 bits (269), Expect = 2e-23
Identities = 95/336 (28%), Positives = 163/336 (48%), Gaps = 15/336 (4%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWM-PIHEAAYHNSVECLQMLINADSSEN 70
S + LA G ++ + LL +V+ N+G + P+ A+ ++ +++L+ D+ N
Sbjct: 240 SLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVN 299
Query: 71 YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRL 130
++ G AL A + G IV++LL GA+ TPL A G ++V R+
Sbjct: 300 ---SQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 131 LLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
LL HGA +N + ++L A ++ + ++++ LL GA++E + D T L A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+E +L+ SGA VN A +PL +AA GH + LL+ GA +L D P
Sbjct: 417 HVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGA--NLEEVNDEGYTP 474
Query: 251 IHAAAQMGHTKILDLLIPL-TNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQ 309
+ AA+ GH +++ LL+ N T + + + A GG + + L++ G
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG------ 528
Query: 310 ACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
A + G S+P+ A Q+ +V LL GA ++
Sbjct: 529 ADIELGCSTPLMEASQEG--HLELVKYLLASGANVH 562
Score = 99.0 bits (245), Expect = 9e-21
Identities = 85/286 (29%), Positives = 139/286 (48%), Gaps = 11/286 (3%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A +G+V+V R LL G V++ + P+ AA VE +LI ++ ++
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN---LEEVN 468
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLE-ETTPLFLAVENGQIDVLRLLLQHG 135
EG+ L AA +GH ++V +LL GA+ NA T E + T L LA G +V L++ G
Sbjct: 469 DEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAG 528
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A++ S L +AS + + E++K LL GAN G T L A + G +
Sbjct: 529 ADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVA 584
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPD-LYCNEDSWQLPIHAA 254
+L+ +GA++ ++ TPL AA+ GH V+ L+S GA+ + N D + + A
Sbjct: 585 DVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACA 644
Query: 255 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
GH +++LL+ + + + A GGH + + LL
Sbjct: 645 G--GHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLL 688
Score = 97.8 bits (242), Expect = 2e-20
Identities = 73/266 (27%), Positives = 120/266 (45%), Gaps = 6/266 (2%)
Query: 82 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 141
AL LA + GH ++V +L+ A + TPL LA G + V+ +LL G ++
Sbjct: 1058 ALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQ 1117
Query: 142 HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 201
L A E++ LLL +GANKE ++ TPL +AA G + + IL+++
Sbjct: 1118 SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA 1177
Query: 202 GANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 259
GA +N + K +PL +AA GH V+LLL G+D + E + + A G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQI-ETNRNTALTLACFQGR 1236
Query: 260 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSP 319
+++ LL+ ++P+ A GG+ + +LL G +A S
Sbjct: 1237 AEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPP---VPSSRD 1293
Query: 320 VCMAFQKDCEFFGIVNILLKYGAQIN 345
+ D + +L+ GA I+
Sbjct: 1294 TALTIAADKGHYKFCELLIHRGAHID 1319
Score = 96.7 bits (239), Expect = 5e-20
Identities = 86/289 (29%), Positives = 131/289 (45%), Gaps = 41/289 (14%)
Query: 57 ECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNA-TTLEETTP 115
E + +LI D+ I+ + +GF L LAA+ GH +V+ILL+ G D A + + TP
Sbjct: 1069 ELVSVLIARDAK---IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTP 1125
Query: 116 LFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGA--NKE 173
L LA G+ +V+ LLL GAN ++ + L A+ IIK+LL GA N
Sbjct: 1126 LSLACSGGRQEVVDLLLARGAN-KEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 1184
Query: 174 CQDDFGITPLFVAAQYGKLESLSILISSGANVNCQ-----------------------AL 210
GI+PL +AA G + ++ +L+ G+++N Q L
Sbjct: 1185 TGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLL 1244
Query: 211 DK-----------ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGH 259
D+ TPL AA G+ + +LL GAD + S + AA GH
Sbjct: 1245 DRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGH 1304
Query: 260 TKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 308
K +LLI +P++ A GGH D +++L++ G DA
Sbjct: 1305 YKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Score = 88.2 bits (217), Expect = 2e-17
Identities = 66/222 (29%), Positives = 117/222 (52%), Gaps = 5/222 (2%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVD--VADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
+ LAA G V +++ LL G ++ G P+ AA + V +++L++ S N
Sbjct: 1159 LSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN- 1217
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
+++T AL LA QG ++V +LL+ A+ TPL A G +V R+L
Sbjct: 1218 AQIETNRN-TALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
Query: 132 LQHGANVNGSHSMCGWNS-LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYG 190
L GA+VN ++ L A+ + + + +LL+ +GA+ + ++ G TPL++A+ G
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGG 1336
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
+ + +L+ +GA+V+ K TPL A ++GH K V+ L+
Sbjct: 1337 HFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLV 1378
Score = 73.6 bits (179), Expect = 4e-13
Identities = 75/268 (27%), Positives = 120/268 (44%), Gaps = 16/268 (5%)
Query: 86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 145
A S G V+ LL+ G N T E + L LA G ++ ++LL ANV +
Sbjct: 212 ACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271
Query: 146 GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANV 205
L AS +I+KLLL A+ Q G T L A G ++ + +L++ GAN+
Sbjct: 272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANI 331
Query: 206 NCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL 265
+ TPL AA GH + +LL GA + + NE + + A GH LD+
Sbjct: 332 EDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFK-ESALTLACYKGH---LDM 387
Query: 266 LIPLTNRACDTGLNKVSPVYSAV----FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVC 321
+ L D +K +++A+ GH + +LL +G + A F SP+
Sbjct: 388 VRFLLEAGADQE-HKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPA---DSFESPLT 443
Query: 322 MAFQKDC-EFFGIVNILLKYGAQINELH 348
+A C + +L++ GA + E++
Sbjct: 444 LA---ACGGHVELAALLIERGANLEEVN 468
Score = 63.5 bits (153), Expect = 4e-10
Identities = 56/202 (27%), Positives = 93/202 (46%), Gaps = 8/202 (3%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
TE +T T LA G +V L+K G +++ + P+ EA+ +E ++ L+
Sbjct: 501 TEETQETALT--LACCGGFSEVADFLIKAGADIELGCST---PLMEASQEGHLELVKYLL 555
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
+ ++ + T G AL A GH + +LL+AGAD + TPL A G
Sbjct: 556 ASGAN---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 612
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
+ ++ L+ GANVN + + + A + +++LLL GA+ + G T L
Sbjct: 613 HLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 672
Query: 184 FVAAQYGKLESLSILISSGANV 205
AA+ G +S L+ NV
Sbjct: 673 IEAAKGGHTNVVSYLLDYPNNV 694
Score = 59.7 bits (143), Expect = 6e-09
Identities = 47/165 (28%), Positives = 78/165 (47%), Gaps = 4/165 (2%)
Query: 181 TPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
T L +A G E +S+LI+ A + + TPL +AA GH VE+LL G D +
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
+E + P+ A G +++DLL+ ++ +P+ A GG+ + ++ILL
Sbjct: 1117 Q-SERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILL 1175
Query: 301 RNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
G +++ G SP+ +A V +LL G+ IN
Sbjct: 1176 NAGAEINSRTGSKLGI-SPLMLAAMNG--HVPAVKLLLDMGSDIN 1217
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 124 bits (312), Expect = 2e-28
Identities = 94/334 (28%), Positives = 161/334 (48%), Gaps = 18/334 (5%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA G+V+++ LL KG +++ D + +H AAY ++ + +LIN + + K
Sbjct: 122 AALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAE---VTCKD 178
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
+G+ LH AAS G +V+ LL G + + + T L +A NGQ V+ L+ +GA
Sbjct: 179 KKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGA 238
Query: 137 NVNGSHSMCGWNSLHQASFQENAEI-IKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
NVN ++ G+ LH A+ + + ++LL+ GA+ Q G +PL + A +G+
Sbjct: 239 NVNQPNNN-GFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRS 297
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
LI +G ++C D TPL +AA+ GH + L +SGAD C S P+H AA
Sbjct: 298 QTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD-TAKCGIHS-MFPLHLAA 355
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG---YSPDAQACL 312
H+ L+ + +++A GG+ +C+++L +G + D
Sbjct: 356 LNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRT 415
Query: 313 VFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE 346
+++ C F + L+ GA +NE
Sbjct: 416 PLHYAAANC--------HFHCIETLVTTGANVNE 441
Score = 117 bits (294), Expect = 2e-26
Identities = 94/354 (26%), Positives = 147/354 (41%), Gaps = 63/354 (17%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN----- 70
+AA G+ +++ L+ G V+ DN P+H A S E +Q+LI + N
Sbjct: 22 VAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKN 81
Query: 71 -------------------------YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP 105
+ + G ALH AA GH ++V +LL GA+
Sbjct: 82 WQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANI 141
Query: 106 NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLL 165
NA ++ L A G +DV+ LL+ HGA V G+ LH A+ ++K L
Sbjct: 142 NAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK-GYTPLHAAASNGQINVVKHL 200
Query: 166 LRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH- 224
L G + + +G T L +A G+ ++ LI GANVN + TPL AA H
Sbjct: 201 LNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHG 260
Query: 225 TKCVELLLSSGADPDLY-------------------------------CNEDSWQLPIHA 253
C+ELL+++GAD ++ C + P+H
Sbjct: 261 ALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHV 320
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 307
AA+ GH +++ L G++ + P++ A H DC LL +G+ D
Sbjct: 321 AARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID 374
Score = 115 bits (287), Expect = 1e-25
Identities = 77/281 (27%), Positives = 137/281 (48%), Gaps = 9/281 (3%)
Query: 26 LRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHL 85
L LL+ + + D G+ IH AA + +CL++L+ +S + + + LHL
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS-GFEESDSGATKSPLHL 548
Query: 86 AASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMC 145
AA GH + +++LL++ D + + T L LA G + + L+ GA++ ++
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 146 GWNSLHQASFQENAEIIKLLLRKGANKEC---QDDFGITPLFVAAQYGKLESLSILISSG 202
LH + + ++LLL N E +D G TPL +A YG ++++S+L+
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 203 ANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKI 262
ANV+ + T L GH +CV++LL + + C + + P+H AA GH
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQ--EVSILCKDSRGRTPLHYAAARGHATW 726
Query: 263 LDLLIPLT---NRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
L L+ + C +P++ A + G+E+C+E+LL
Sbjct: 727 LSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Score = 112 bits (281), Expect = 6e-25
Identities = 91/305 (29%), Positives = 148/305 (48%), Gaps = 22/305 (7%)
Query: 10 TCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS- 68
T S + LAA G+ + L LL+ +D+ D +G + AA+ EC++ LIN +S
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 69 --ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET---TPLFLAVENG 123
++ + +T LH + GH +++LLE +P A +++ TPL LAV G
Sbjct: 602 FVKDNVTKRT-----PLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYG 656
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
ID + LLL+ ANV+ + + G +LH+ + E +++LL + + C+D G TPL
Sbjct: 657 HIDAVSLLLEKEANVD-TVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL 715
Query: 184 FVAAQYGKLESLSILISSG-ANVNCQALDKA--TPLFIAAQEGHTKCVELLLSSGADPDL 240
AA G LS L+ + +C D TPL A G+ C+E+LL
Sbjct: 716 HYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKF 775
Query: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNR---ACDTGLNKVSPVYSAVFGGHEDCLE 297
N + P+H A H LL+ + +C + +P+ +A F H +CL+
Sbjct: 776 IGNPFT---PLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGR-TPLRAAAFADHVECLQ 831
Query: 298 ILLRN 302
+LLR+
Sbjct: 832 LLLRH 836
Score = 104 bits (259), Expect = 2e-22
Identities = 84/286 (29%), Positives = 132/286 (46%), Gaps = 13/286 (4%)
Query: 29 LLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAAS 88
L+ K V+ D+ P+H AA+ E +++LI + + N K LH A +
Sbjct: 2 LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVN---AKDNMWLTPLHRAVA 58
Query: 89 QGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWN 148
+ VQ+L++ AD NA TPL +A N + +++ ++VN S G
Sbjct: 59 SRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVS-DRGGRT 117
Query: 149 SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQ 208
+LH A+ + E++ LLL KGAN D L AA G L+ +++LI+ GA V C+
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCK 177
Query: 209 ALDKATPLFIAAQEGHTKCVELLLSSGADPD---LYCNEDSWQLPIHAAAQMGHTKILDL 265
TPL AA G V+ LL+ G + D +Y N +H A G +++
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGN-----TALHIACYNGQDAVVNE 232
Query: 266 LIPLTNRACDTGLNKVSPVYSAVFGGHED-CLEILLRNGYSPDAQA 310
LI N +P++ A H CLE+L+ NG + Q+
Sbjct: 233 LIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Score = 100 bits (250), Expect = 2e-21
Identities = 96/325 (29%), Positives = 147/325 (45%), Gaps = 38/325 (11%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LAA + RKLL G +D D G +H AA +VEC+++L SS K
Sbjct: 353 LAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLL---QSSGADFHKK 409
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAV--------------- 120
G LH AA+ H+ ++ L+ GA+ N T T L A
Sbjct: 410 DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAH 469
Query: 121 -------------ENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLR 167
E L LLQ+ AN + G+NS+H A+ + + ++LLL
Sbjct: 470 DNSEELERARELKEKEATLCLEFLLQNDANPS-IRDKEGYNSIHYAAAYGHRQCLELLLE 528
Query: 168 KGANKECQDDFGIT--PLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 225
+ + + D G T PL +AA G ++L +L+ S +++ + T L +AA +GHT
Sbjct: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHT 588
Query: 226 KCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTN--RACDTGLNK-VS 282
+CVE L++ GA + N + P+HA+ GHT L LL+ + + A D K +
Sbjct: 589 ECVEALINPGASIFVKDNVTK-RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647
Query: 283 PVYSAVFGGHEDCLEILLRNGYSPD 307
P+ AV GH D + +LL + D
Sbjct: 648 PLMLAVAYGHIDAVSLLLEKEANVD 672
Score = 90.9 bits (224), Expect = 3e-18
Identities = 76/259 (29%), Positives = 113/259 (43%), Gaps = 15/259 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LA G++ + LL+K +VD D G +H EC+QML+ + S I K
Sbjct: 651 LAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS---ILCK 707
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET---TPLFLAVENGQIDVLRLLL 132
G LH AA++GH + LL+ ++ TPL A NG + + +LL
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Query: 133 QHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLRK--GANKECQDDFGITPLFVAAQ 188
+ G + LH A ++ LLL + C+DD G TPL AA
Sbjct: 768 EQKC----FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAF 823
Query: 189 YGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQ 248
+E L +L+ A VN T L +AA+ G V++L++S A DL +
Sbjct: 824 ADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS-AQADLTVKDKDLN 882
Query: 249 LPIHAAAQMGHTKILDLLI 267
P+H A GH K L++
Sbjct: 883 TPLHLACSKGHEKCALLIL 901
Score = 90.1 bits (222), Expect = 4e-18
Identities = 76/246 (30%), Positives = 116/246 (47%), Gaps = 14/246 (5%)
Query: 5 EAYADTCSTVGLAARE-----GNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECL 59
EA DT +G A G+ + ++ LL++ S+ D+RG P+H AA L
Sbjct: 668 EANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWL 727
Query: 60 QMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLA 119
L+ SE K +G+ LH A G+ +++LLE TPL A
Sbjct: 728 SELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG-NPFTPLHCA 786
Query: 120 VENGQIDVLRLLLQHGANVNGSHSMC----GWNSLHQASFQENAEIIKLLLRKGANKECQ 175
+ N + LLL GA ++ S C G L A+F ++ E ++LLLR A
Sbjct: 787 IINDHGNCASLLL--GA-IDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAV 843
Query: 176 DDFGITPLFVAAQYGKLESLSILISSG-ANVNCQALDKATPLFIAAQEGHTKCVELLLSS 234
D+ G T L +AA+ G+ ++ IL++S A++ + D TPL +A +GH KC L+L
Sbjct: 844 DNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDK 903
Query: 235 GADPDL 240
D L
Sbjct: 904 IQDESL 909
Score = 65.9 bits (159), Expect = 9e-11
Identities = 48/181 (26%), Positives = 83/181 (45%), Gaps = 7/181 (3%)
Query: 164 LLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 223
+L+ K + D TPL VAA G E + +LI SGA VN + TPL A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 224 HTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSP 283
+ V++L+ A D+ + +WQ P+H AA K +++IPL + + +
Sbjct: 61 SEEAVQVLIKHSA--DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTA 118
Query: 284 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 343
++ A GH + + +LL G + +A F + + +V +L+ +GA+
Sbjct: 119 LHHAALNGHVEMVNLLLAKGANINA-----FDKKDRRALHWAAYMGHLDVVALLINHGAE 173
Query: 344 I 344
+
Sbjct: 174 V 174
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 122 bits (307), Expect = 6e-28
Identities = 93/332 (28%), Positives = 167/332 (50%), Gaps = 15/332 (4%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA +GN++++++L+K G + ++ D W + A+ V ++ L+ + ++ +
Sbjct: 44 IAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVN---LEHR 100
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G+ AL A +G +V++LL GA+P+ T L P+ A G D++ LLLQ+G
Sbjct: 101 DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNG 160
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A VN S G L A+ + + E +K LL GA+ + + +T L VA + G +S+
Sbjct: 161 AKVNCSDKY-GTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSV 219
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCN--EDSWQLPIHA 253
++ NVN D T L IA++EGHT+ V+ LL +G Y N + S +
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGT----YVNIPDRSGDTVLIG 275
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 313
A + GH +I+ L+ G + + +Y AV G+ + +L+ +PD + C
Sbjct: 276 AVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQ--CNPDTEICTK 333
Query: 314 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
G + + ++ E +V +LL GA+++
Sbjct: 334 DGETPLIKATKMRNIE---VVELLLDKGAKVS 362
Score = 122 bits (305), Expect = 1e-27
Identities = 92/290 (31%), Positives = 156/290 (53%), Gaps = 22/290 (7%)
Query: 20 EGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEG 79
E N+ L+ LL+K + VD + G P+ AA ++E ++ LI ++ N ++ +
Sbjct: 15 EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN---LEDLDN 71
Query: 80 FCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN-- 137
+ AL A+ +GH IV+ LL+ G + + T L A G+ DV+ LLL HGAN
Sbjct: 72 WTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPS 131
Query: 138 VNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSI 197
V G +S+ + A+ + +A+I+ LLL+ GA C D +G TPL AA+ G LE +
Sbjct: 132 VTGLYSVY---PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKH 188
Query: 198 LISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQM 257
L++ GA+V+ + + T L +A + G+T+ V+ +L +P++ + + A++
Sbjct: 189 LLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILK--RNPNVNLTDKDGNTALMIASKE 246
Query: 258 GHTKIL-DLL-----IPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
GHT+I+ DLL + + +R+ DT L AV GGH + + LL+
Sbjct: 247 GHTEIVQDLLDAGTYVNIPDRSGDTVL------IGAVRGGHVEIVRALLQ 290
Score = 84.0 bits (206), Expect = 3e-16
Identities = 53/148 (35%), Positives = 81/148 (54%), Gaps = 2/148 (1%)
Query: 156 QENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATP 215
+EN +K LL K + + +++ G TPL +AA+ G LE + LI +GAN N + LD T
Sbjct: 15 EENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTA 74
Query: 216 LFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD 275
L A++EGH VE LL G + + + + W + A + G T +++LL+
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLE-HRDMGGWTALMWACYK-GRTDVVELLLSHGANPSV 132
Query: 276 TGLNKVSPVYSAVFGGHEDCLEILLRNG 303
TGL V P+ A GH D + +LL+NG
Sbjct: 133 TGLYSVYPIIWAAGRGHADIVHLLLQNG 160
Score = 80.9 bits (198), Expect = 3e-15
Identities = 68/251 (27%), Positives = 112/251 (44%), Gaps = 31/251 (12%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI--NADSSEN---- 70
AA G+ ++ LL+ G V+ +D G P+ AA +EC++ L+ AD +
Sbjct: 144 AAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 71 ------------------------YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN 106
+ + +G AL +A+ +GH +IVQ LL+AG N
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
Query: 107 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL 166
T L AV G ++++R LLQ A+++ +L+ A + NA +++ +L
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRALLQKYADID-IRGQDNKTALYWAVEKGNATMVRDIL 322
Query: 167 RKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTK 226
+ + E G TPL A + +E + +L+ GA V+ TPL IA + K
Sbjct: 323 QCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRK 382
Query: 227 CVELLLSSGAD 237
ELLL + D
Sbjct: 383 LAELLLRNPKD 393
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 122 bits (305), Expect = 1e-27
Identities = 92/297 (30%), Positives = 142/297 (47%), Gaps = 15/297 (5%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA GNV+ L LL G + D G P+H AA + S +C L+ A + N K
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK- 488
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
G LH AA+ ++ + P++ EE PL + L LL +GA
Sbjct: 489 --GCSPLHYAAASDTYRRAE-----PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGA 541
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN--KECQDDFGITPLFVAAQYGKLES 194
+ + G+ ++H A+ N + ++LLL N ++ + ++PL +AA G E+
Sbjct: 542 DPS-LRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEA 600
Query: 195 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 254
L L + N++ + T LF+A + G T+CVE+L + GA + + W P+HAA
Sbjct: 601 LKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWT-PLHAA 659
Query: 255 AQMGHTKILDLLIPLTNRACDTGLNKV---SPVYSAVFGGHEDCLEILLRNGYSPDA 308
A GHT L LLI RA T + +P+ A+ GH DC+ +LL G + DA
Sbjct: 660 AASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADA 716
Score = 121 bits (304), Expect = 1e-27
Identities = 88/290 (30%), Positives = 147/290 (50%), Gaps = 9/290 (3%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AA K L S++VAD G +H A + +E + +L+N +S N K
Sbjct: 113 VAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKK 172
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
+ LH AA GH +++++L+ GAD + L A +GQI+V++ LL+ G
Sbjct: 173 ERQ---PLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMG 229
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA--QYGKLE 193
A ++ ++ G +LH A + + L+ GAN +D G TPL VAA G L
Sbjct: 230 AEIDEPNAF-GNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGAL- 287
Query: 194 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 253
L +L+++GA+VN Q+ + +PL +AA G ++L+ +G++ D C + P+H
Sbjct: 288 CLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID--CADKFGNTPLHV 345
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 303
AA+ GH ++ L+ G++ + P++ AV G DC LL +G
Sbjct: 346 AARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Score = 116 bits (290), Expect = 6e-26
Identities = 83/285 (29%), Positives = 139/285 (48%), Gaps = 12/285 (4%)
Query: 26 LRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIK-MKTFEGFCALH 84
L LL G + D +G+ +H AA + + + L++L+ + S N ++ +++ LH
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLL--EMSFNCLEDVESTIPVSPLH 590
Query: 85 LAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSM 144
LAA GH + ++ L E + + + T LFLA E G + + +L HGA+
Sbjct: 591 LAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERK 650
Query: 145 CGWNSLHQASFQENAEIIKLLLRKGAN---KECQDDFGITPLFVAAQYGKLESLSILISS 201
W LH A+ + + + LL+ G + D +G TPL +A G ++ + +L+
Sbjct: 651 RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEK 710
Query: 202 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTK 261
G+ + L T L A G C+ LL D + C + + PIH A+ GHT
Sbjct: 711 GSTADAADLRGRTALHRGAVTGCEDCLAALLDH--DAFVLCRDFKGRTPIHLASACGHTA 768
Query: 262 ILDLLI--PLTNRACDTGL--NKVSPVYSAVFGGHEDCLEILLRN 302
+L L+ L+ D G+ + SP++ A + GHEDCLE+LL +
Sbjct: 769 VLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH 813
Score = 108 bits (271), Expect = 9e-24
Identities = 84/305 (27%), Positives = 139/305 (45%), Gaps = 44/305 (14%)
Query: 2 DFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQM 61
D +AY T + LA G+V + LL+KG + D AD RG +H A +CL
Sbjct: 682 DVMDAYGQT--PLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAA 739
Query: 62 LINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAG--ADPNATTLEET--TPLF 117
L++ D+ ++ + F+G +HLA++ GH +++ LL+A DP ++ + +P+
Sbjct: 740 LLDHDA---FVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMH 796
Query: 118 LAVENGQIDVLRLLLQH---------------------------------GANVNGSHSM 144
A G D L LLL+H GA + S
Sbjct: 797 WASYTGHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDA 856
Query: 145 CGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSG-A 203
G LH A+F +N +++LL+ A D G T L AA+ G+ ++ L+ G A
Sbjct: 857 KGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKA 916
Query: 204 NVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY-CNEDSWQLPIHAAAQMGHTKI 262
++ +K T L +A +GH KC ++L+ D L + Q+P+H AA+ G +
Sbjct: 917 DLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASV 976
Query: 263 LDLLI 267
+ L+
Sbjct: 977 VQALL 981
Score = 104 bits (260), Expect = 2e-22
Identities = 90/345 (26%), Positives = 149/345 (43%), Gaps = 54/345 (15%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A G+++ + LL KG S++V D + P+H AA+ +E L++L+ + + K
Sbjct: 147 AVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGAD---LGCKD 203
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
+G+ LH AA+ G ++V+ LL GA+ + T L +A GQ V L+ GA
Sbjct: 204 RKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGA 263
Query: 137 NVNGSHSMCGWNSLHQASFQENAEII---------------------------------- 162
NVN + G+ LH A+ N +
Sbjct: 264 NVNQPNDK-GFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRS 322
Query: 163 KLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE 222
++L++ G+ +C D FG TPL VAA+YG +S L+++GA+ + + PL +A
Sbjct: 323 QILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLF 382
Query: 223 GHTKCVELLLSSG----------------ADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266
G + C LLSSG A D+ ++ + +HAAA G+ + L+LL
Sbjct: 383 GFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLL 442
Query: 267 IPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQAC 311
+ +P++ A G C L+ G + C
Sbjct: 443 LSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADC 487
Score = 104 bits (260), Expect = 2e-22
Identities = 103/377 (27%), Positives = 158/377 (41%), Gaps = 82/377 (21%)
Query: 1 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYH-NSVECL 59
+D A+ +T + +A G V +L+ G +V+ +++G+ P+H AA N CL
Sbjct: 232 IDEPNAFGNTA--LHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCL 289
Query: 60 QMLINADSSENY--------IKMKTFEGF---------------CA-------LHLAASQ 89
++L+N + NY + M G CA LH+AA
Sbjct: 290 ELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349
Query: 90 GHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG------ANVNGSHS 143
GH ++ L+ GAD + + PL LAV G D R LL G ++++ H
Sbjct: 350 GHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHV 409
Query: 144 MC-----------GWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKL 192
+ G LH A+ N E + LLL GA+ +D FG TPL AA G
Sbjct: 410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469
Query: 193 ESLSILISSGANVNCQALDKATPLFIAA-------QEGHTK------------------- 226
+ L+++GA VN +PL AA E HT
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEA 529
Query: 227 --CVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACD--TGLNKVS 282
C+E LL +GADP L + +H AA G+ + L+LL+ ++ + VS
Sbjct: 530 FFCLEFLLDNGADPSL--RDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVS 587
Query: 283 PVYSAVFGGHEDCLEIL 299
P++ A + GH + L+ L
Sbjct: 588 PLHLAAYNGHCEALKTL 604
Score = 90.9 bits (224), Expect = 3e-18
Identities = 81/305 (26%), Positives = 145/305 (47%), Gaps = 25/305 (8%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
S + LAA G+ + L+ L + ++DV D++G + A S EC+++L A +
Sbjct: 587 SPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVL-TAHGASAL 645
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEET---TPLFLAVENGQIDVL 128
IK + + LH AA+ GH + +L+++G + T + + TPL LA+ NG +D +
Sbjct: 646 IKERK-RKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCV 704
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQ 188
LLL+ G+ + + + G +LH+ + + + LL A C+D G TP+ +A+
Sbjct: 705 HLLLEKGSTADAA-DLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASA 763
Query: 189 YGKLESLSILISSGANVNCQALDKA------TPLFIAAQEGHTKCVELLLSSGADPDLYC 242
G L L+ A ++ LD +P+ A+ GH C+ELLL P Y
Sbjct: 764 CGHTAVLRTLLQ--AALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEH--SPFSYL 819
Query: 243 NEDSWQLPIHAAAQMGHTKILDLLI-----PLTNRACDTGLNKVSPVYSAVFGGHEDCLE 297
+ + P+H A ++L+ + N G +P+++A F + L
Sbjct: 820 EGNPF-TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGR---TPLHAAAFADNVSGLR 875
Query: 298 ILLRN 302
+LL++
Sbjct: 876 MLLQH 880
Score = 83.2 bits (204), Expect = 5e-16
Identities = 67/223 (30%), Positives = 110/223 (49%), Gaps = 8/223 (3%)
Query: 46 PIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP 105
P+ +A + VE ++ L++ + N + E LH AA G I+Q+LL +GA+
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQ---ERRTPLHAAAYVGDVPILQLLLMSGANV 67
Query: 106 NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNS-LHQASFQENAEIIKL 164
NA TPL A + VL LLL H A+VN + W + LH A+ + +
Sbjct: 68 NAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKL--WQTPLHVAAANRATKCAEA 125
Query: 165 LLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGH 224
L ++ D G + L A G LE++++L++ GA++N + PL AA GH
Sbjct: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185
Query: 225 TKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI 267
+ ++LL++ GA DL C + +H AA G +++ L+
Sbjct: 186 LEVLKLLVARGA--DLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Score = 79.7 bits (195), Expect = 6e-15
Identities = 74/265 (27%), Positives = 123/265 (46%), Gaps = 26/265 (9%)
Query: 109 TLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK 168
++ + PL A+ + ++ +R LL N+N LH A++ + I++LLL
Sbjct: 5 SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR-TPLHAAAYVGDVPILQLLLMS 63
Query: 169 GANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCV 228
GAN +D +TPL AA + L +L++ A+VN + TPL +AA TKC
Sbjct: 64 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123
Query: 229 EL---LLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI--PLTNRACDTGLNKVSP 283
E LLSS L + S + +H A GH + ++LL+ + CD + P
Sbjct: 124 EALAPLLSS-----LNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK--KERQP 176
Query: 284 VYSAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQ 343
++ A F GH + L++L+ G + +G + Q + +V LL+ GA+
Sbjct: 177 LHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIE-----VVKYLLRMGAE 231
Query: 344 INE--------LHLAYCLKYEKFSI 360
I+E LH+A L + +I
Sbjct: 232 IDEPNAFGNTALHIACYLGQDAVAI 256
Score = 73.2 bits (178), Expect = 5e-13
Identities = 73/293 (24%), Positives = 118/293 (40%), Gaps = 7/293 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADN-RGWMPIHEAAYHNSVECLQMLINADSSENYIKM 74
LA G+ + + L G S + + R W P+H AA + L +LI++ + +
Sbjct: 624 LATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDV 683
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
G L LA GH V +LLE G+ +A L T L G D L LL H
Sbjct: 684 MDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDH 743
Query: 135 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD---DF-GITPLFVAAQYG 190
A V G +H AS + +++ LL+ + + D D+ G +P+ A+ G
Sbjct: 744 DAFVL-CRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTG 802
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ L +L+ + + TPL A E+LL + + + + P
Sbjct: 803 HEDCLELLLEHSPFSYLEG-NPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNG 303
+HAAA + L +L+ T + + +A G +E LL G
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Score = 58.9 bits (141), Expect = 1e-08
Identities = 69/265 (26%), Positives = 104/265 (39%), Gaps = 49/265 (18%)
Query: 14 VGLAAREGNVKVLRKLLKKGRSVDV----ADNRGWMPIHEAAYHNSVECLQMLI------ 63
+ LA+ G+ VLR LL+ S D D G+ P+H A+Y +CL++L+
Sbjct: 758 IHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFS 817
Query: 64 ----------------NADSSENY---------IKMKTFEGFCALHLAASQGHWKIVQIL 98
N DS+ + + +G LH AA + +++L
Sbjct: 818 YLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRML 877
Query: 99 LEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA--------NVNGSHSMCGWNSL 150
L+ A+ NAT T L A ENGQ + LL G N N + +
Sbjct: 878 LQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGH 937
Query: 151 HQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQAL 210
+ + AE L L N Q PL +AA+ G + L+S GA V
Sbjct: 938 EKCALMILAETQDLGLINATNSALQ-----MPLHIAARNGLASVVQALLSHGATVLAVDE 992
Query: 211 DKATP-LFIAAQEGHTKCVELLLSS 234
+ TP L A + C+ L+LS+
Sbjct: 993 EGHTPALACAPNKDVADCLALILST 1017
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 122 bits (305), Expect = 1e-27
Identities = 97/335 (28%), Positives = 155/335 (46%), Gaps = 13/335 (3%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
S + LA G + + LL + ++++ RG P+H A +++L+ S N
Sbjct: 440 SLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVN- 498
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
K + + ALH AA G ++LLE A N E TP+ +A ++GQ +++R+L
Sbjct: 499 --AKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRK-GANKECQDDFGITPLFVAAQYG 190
L+ G +V+ W LH A++Q + I+KLL ++ G + Q G TPL +AAQ G
Sbjct: 557 LRRGVDVS-LQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRG 615
Query: 191 KLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
ILI ++VN +L TPL +AA+ GHT LLL GA + ++
Sbjct: 616 HYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDG--YTA 673
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQA 310
+H AA+ GH + LL+ G + ++ A GH + +E L+ A
Sbjct: 674 LHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELV------SADV 727
Query: 311 CLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN 345
+F + V LL++GA IN
Sbjct: 728 IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 105 bits (262), Expect = 1e-22
Identities = 68/225 (30%), Positives = 115/225 (51%), Gaps = 4/225 (1%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+A + G ++R LL++G V + W+P+H AA+ + +++L + +
Sbjct: 543 VACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS--VNAQ 600
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
T +G LHLAA +GH+++ +IL++ +D N +L TPL +A E G RLLL G
Sbjct: 601 TLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG 660
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
A S G+ +LH A+ + +KLL+ + A+ + T L +AA +G E +
Sbjct: 661 AGKEAMTS-DGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVV 719
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
L+S+ ++ + L +AAQ H + VE LL GA +L
Sbjct: 720 EELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINL 763
Score = 105 bits (261), Expect = 1e-22
Identities = 76/232 (32%), Positives = 111/232 (47%), Gaps = 6/232 (2%)
Query: 79 GFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANV 138
G LHLA G + + LL A+PN + +TPL +AVE V+ LLL +V
Sbjct: 438 GASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISV 497
Query: 139 NGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSIL 198
N W +LH A+ + +LLL K A+ D G TP+ VA Q+G+ + IL
Sbjct: 498 NAKDED-QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 556
Query: 199 ISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDS--WQLPIHAAAQ 256
+ G +V+ Q D PL AA +GH V+LL P + N + + P+H AAQ
Sbjct: 557 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLL---AKQPGVSVNAQTLDGRTPLHLAAQ 613
Query: 257 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 308
GH ++ +LI L + L +P++ A GH +LL G +A
Sbjct: 614 RGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEA 665
Score = 47.8 bits (112), Expect = 2e-05
Identities = 39/133 (29%), Positives = 59/133 (44%), Gaps = 2/133 (1%)
Query: 177 DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGA 236
D G + L +A + G+ E L+ + AN N +TPL +A + VELLL+
Sbjct: 436 DSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKI 495
Query: 237 DPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCL 296
+ +ED W +H AAQ G LL+ + +P++ A G E+ +
Sbjct: 496 SVNAK-DEDQW-TALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIV 553
Query: 297 EILLRNGYSPDAQ 309
ILLR G Q
Sbjct: 554 RILLRRGVDVSLQ 566
Score = 46.2 bits (108), Expect = 7e-05
Identities = 32/104 (30%), Positives = 53/104 (50%), Gaps = 4/104 (3%)
Query: 8 ADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADS 67
+D + + LAAR G++ ++ L+++ V +H AA H E ++ L++AD
Sbjct: 668 SDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSAD- 726
Query: 68 SENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLE 111
I + +G ALHLAA H + V+ LL GA N +L+
Sbjct: 727 ---VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLK 767
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 121 bits (304), Expect = 1e-27
Identities = 101/355 (28%), Positives = 175/355 (49%), Gaps = 15/355 (4%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
TE+ DT T LA G+ ++++ LL++G S++ D +G+ P+ AA V +++L+
Sbjct: 1079 TESNHDTALT--LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 1136
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
+ + +T + L LA S G ++V++LL GA+ + + TPL LA G
Sbjct: 1137 DNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 1194
Query: 124 QIDVLRLLLQHGANVNG-SHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI-T 181
++++++LL GA +N + S G + L A+ + +KLLL G++ Q + T
Sbjct: 1195 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1254
Query: 182 PLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 241
L +A G+ E +S+L+ ANV +A TPL AA G+ + +LL GAD +
Sbjct: 1255 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 242 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
S + AA GH K +LLI +P++ A GGH D +++L++
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
Query: 302 NGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL-AYCLKY 355
G DA +P+ AF+K G V ++ ++N+ + C++Y
Sbjct: 1375 AGADVDAADNRKI---TPLMAAFRK-----GHVKVVRYLVKEVNQFPSDSECMRY 1421
Score = 118 bits (295), Expect = 1e-26
Identities = 100/331 (30%), Positives = 158/331 (47%), Gaps = 14/331 (4%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI--NADSSENYIKM 74
A EG+V +RKLL +GRSV+ G + A E Q+L+ +A+ + IK
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK- 299
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
L AA+ GH KIV++LL AD NA + T L A G +DV+++LL+
Sbjct: 300 ---GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 135 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLE 193
GA++ H+ G L +A + E+ +LLL GA ++F + L +A G LE
Sbjct: 357 GASIE-DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLE 415
Query: 194 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 253
+ L+ +GA+ + + T L A +GH + LLL SGA ++ DS++ P+
Sbjct: 416 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTL 473
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 313
AA GH ++ LLI + +P+ A GHE+ + +LL G + +AQ
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT--- 530
Query: 314 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 344
+ + F + + L+K GA I
Sbjct: 531 -EETQETALTLACCGGFLEVADFLIKAGADI 560
Score = 117 bits (294), Expect = 2e-26
Identities = 88/261 (33%), Positives = 142/261 (54%), Gaps = 9/261 (3%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
S + LAA G+V++ L+++G S++ ++ G+ P+ EAA E + +L+ ++ N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
+T E AL LA G ++ L++AGAD L +TPL A + G +++++ L
Sbjct: 529 QTEETQE--TALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYL 583
Query: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
L GANV+ + + G +L A + ++ +LL+ GA+ E + + G TPL AA+ G
Sbjct: 584 LAAGANVHAT-TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
Query: 192 LESLSILISSGANVN-CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ ++ LIS GANVN A + T L +A GH VELLL+ GADP + S L
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML- 701
Query: 251 IHAAAQMGHTKILDLLIPLTN 271
AA+ GHT ++ L+ N
Sbjct: 702 -IEAAKGGHTSVVCYLLDYPN 721
Score = 117 bits (293), Expect = 3e-26
Identities = 106/353 (30%), Positives = 153/353 (43%), Gaps = 66/353 (18%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A G V V++ LL+ G S++ + G P+ EA VE ++L+ + N +
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
E AL LA +GH ++V+ LLEAGAD T E T L A +G ++V RLLL GA
Sbjct: 401 KES--ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
VN + L A+ + E+ LL+ +GA+ E +D G TPL AA+ G E ++
Sbjct: 459 QVNMPADSFE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 197 ILISSGANVNCQA-------------------------------LDKATPLFIAAQEGHT 225
+L+ GAN+N Q L +TPL AAQEGH
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHL 577
Query: 226 KCVELLLSSGAD-------------------------------PDLYCNEDSWQLPIHAA 254
+ V+ LL++GA+ DL + + P+ A
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 637
Query: 255 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYS-AVFGGHEDCLEILLRNGYSP 306
A+ GH + LI T N V S A GGH +E+LL +G P
Sbjct: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Score = 65.5 bits (158), Expect = 1e-10
Identities = 57/202 (28%), Positives = 93/202 (46%), Gaps = 8/202 (3%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
TE +T T LA G ++V L+K G +++ + P+ EAA +E ++ L+
Sbjct: 530 TEETQETALT--LACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLELVKYLL 584
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
A ++ + T G AL A GH + +LL+AGAD + TPL A G
Sbjct: 585 AAGAN---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
+ ++ L+ GANVN + + L A + +++LLL GA+ + G T L
Sbjct: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
Query: 184 FVAAQYGKLESLSILISSGANV 205
AA+ G + L+ N+
Sbjct: 702 IEAAKGGHTSVVCYLLDYPNNL 723
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 121 bits (304), Expect = 1e-27
Identities = 101/355 (28%), Positives = 175/355 (49%), Gaps = 15/355 (4%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
TE+ DT T LA G+ ++++ LL++G S++ D +G+ P+ AA V +++L+
Sbjct: 828 TESNHDTALT--LACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
+ + +T + L LA S G ++V++LL GA+ + + TPL LA G
Sbjct: 886 DNGADIEAQSERTKD--TPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGG 943
Query: 124 QIDVLRLLLQHGANVNG-SHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGI-T 181
++++++LL GA +N + S G + L A+ + +KLLL G++ Q + T
Sbjct: 944 YVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNT 1003
Query: 182 PLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLY 241
L +A G+ E +S+L+ ANV +A TPL AA G+ + +LL GAD +
Sbjct: 1004 ALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1063
Query: 242 CNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLR 301
S + AA GH K +LLI +P++ A GGH D +++L++
Sbjct: 1064 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1123
Query: 302 NGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINELHL-AYCLKY 355
G DA +P+ AF+K G V ++ ++N+ + C++Y
Sbjct: 1124 AGADVDAADNRKI---TPLMAAFRK-----GHVKVVRYLVKEVNQFPSDSECMRY 1170
Score = 118 bits (295), Expect = 1e-26
Identities = 100/331 (30%), Positives = 158/331 (47%), Gaps = 14/331 (4%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI--NADSSENYIKM 74
A EG+V +RKLL +GRSV+ G + A E Q+L+ +A+ + IK
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIK- 299
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
L AA+ GH KIV++LL AD NA + T L A G +DV+++LL+
Sbjct: 300 ---GDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES 356
Query: 135 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN-KECQDDFGITPLFVAAQYGKLE 193
GA++ H+ G L +A + E+ +LLL GA ++F + L +A G LE
Sbjct: 357 GASIE-DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLE 415
Query: 194 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 253
+ L+ +GA+ + + T L A +GH + LLL SGA ++ DS++ P+
Sbjct: 416 MVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM--PADSFESPLTL 473
Query: 254 AAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDAQACLV 313
AA GH ++ LLI + +P+ A GHE+ + +LL G + +AQ
Sbjct: 474 AACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT--- 530
Query: 314 FGFSSPVCMAFQKDCEFFGIVNILLKYGAQI 344
+ + F + + L+K GA I
Sbjct: 531 -EETQETALTLACCGGFLEVADFLIKAGADI 560
Score = 117 bits (294), Expect = 2e-26
Identities = 88/261 (33%), Positives = 142/261 (54%), Gaps = 9/261 (3%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
S + LAA G+V++ L+++G S++ ++ G+ P+ EAA E + +L+ ++ N
Sbjct: 469 SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINA 528
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
+T E AL LA G ++ L++AGAD L +TPL A + G +++++ L
Sbjct: 529 QTEETQE--TALTLACCGGFLEVADFLIKAGAD---IELGCSTPLMEAAQEGHLELVKYL 583
Query: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
L GANV+ + + G +L A + ++ +LL+ GA+ E + + G TPL AA+ G
Sbjct: 584 LAAGANVHAT-TATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642
Query: 192 LESLSILISSGANVN-CQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ ++ LIS GANVN A + T L +A GH VELLL+ GADP + S L
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML- 701
Query: 251 IHAAAQMGHTKILDLLIPLTN 271
AA+ GHT ++ L+ N
Sbjct: 702 -IEAAKGGHTSVVCYLLDYPN 721
Score = 117 bits (293), Expect = 3e-26
Identities = 106/353 (30%), Positives = 153/353 (43%), Gaps = 66/353 (18%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
A G V V++ LL+ G S++ + G P+ EA VE ++L+ + N +
Sbjct: 341 ACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEF 400
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
E AL LA +GH ++V+ LLEAGAD T E T L A +G ++V RLLL GA
Sbjct: 401 KES--ALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGA 458
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
VN + L A+ + E+ LL+ +GA+ E +D G TPL AA+ G E ++
Sbjct: 459 QVNMPADSFE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 197 ILISSGANVNCQA-------------------------------LDKATPLFIAAQEGHT 225
+L+ GAN+N Q L +TPL AAQEGH
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHL 577
Query: 226 KCVELLLSSGAD-------------------------------PDLYCNEDSWQLPIHAA 254
+ V+ LL++GA+ DL + + P+ A
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKA 637
Query: 255 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYS-AVFGGHEDCLEILLRNGYSP 306
A+ GH + LI T N V S A GGH +E+LL +G P
Sbjct: 638 ARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADP 690
Score = 66.2 bits (160), Expect = 7e-11
Identities = 92/375 (24%), Positives = 152/375 (40%), Gaps = 47/375 (12%)
Query: 4 TEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI 63
TE +T T LA G ++V L+K G +++ + P+ EAA +E ++ L+
Sbjct: 530 TEETQETALT--LACCGGFLEVADFLIKAGADIELGCST---PLMEAAQEGHLELVKYLL 584
Query: 64 NADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENG 123
A ++ + T G AL A GH + +LL+AGAD + TPL A G
Sbjct: 585 AAGAN---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAG 641
Query: 124 QIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPL 183
+ ++ L+ GANVN + + L A + +++LLL GA+ + G T L
Sbjct: 642 HVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTML 701
Query: 184 FVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQE-GHTKCVEL----LLSSGADP 238
AA+ G + L+ N+ T L + + V + ++ +P
Sbjct: 702 IEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEP 761
Query: 239 DLYCNEDSWQLPIH------AAAQMGHTKILDLLIPLTNRACDTGLNKVS-----PVYSA 287
D + LPI A+ M +T + ++ T +S P+Y A
Sbjct: 762 DKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPA 821
Query: 288 V------------------FGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDCE 329
+ GGHE+ ++ LL G S + + F +P+ +A
Sbjct: 822 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGF---TPLILA--ATAG 876
Query: 330 FFGIVNILLKYGAQI 344
G+V ILL GA I
Sbjct: 877 HVGVVEILLDNGADI 891
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 116 bits (291), Expect = 4e-26
Identities = 86/295 (29%), Positives = 140/295 (47%), Gaps = 17/295 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LA G+ ++R LL++G V D G +HEAA+H ++L+ +S +
Sbjct: 80 LAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGAS---AAAR 136
Query: 76 TFEGFCALHLAASQGHWKIVQILLEA-GADPNATTLEET---TPLFLAVENGQIDVLRLL 131
+ G LH AA+ GH + LLEA G P A E+ T A G++ VL LL
Sbjct: 137 SGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELL 196
Query: 132 LQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGK 191
GA ++G +L A+ ++ LL +GA + +D G T L +AA G+
Sbjct: 197 AAGGAGLDG--------ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGR 248
Query: 192 LESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPI 251
+ + +L+ GA+ + + L AA GH V+LL++ GA+ D + P+
Sbjct: 249 SQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAEVD--ARDTLGLTPL 306
Query: 252 HAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSP 306
H A++ GH ++ L+ + TG + +P++ A GH + +LL G SP
Sbjct: 307 HHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASP 361
Score = 94.0 bits (232), Expect = 3e-19
Identities = 67/206 (32%), Positives = 104/206 (50%), Gaps = 11/206 (5%)
Query: 35 SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKI 94
+ + D RGW H AA + L++L + +G AL +AA+ G
Sbjct: 169 AAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAG--------LDG--ALLVAAAAGRGAA 218
Query: 95 VQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQAS 154
++ LL GA +A T L LA G+ + +LL HGA+ G G ++LH+A+
Sbjct: 219 LRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADP-GIRDRHGRSALHRAA 277
Query: 155 FQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKAT 214
+ + ++LL+ +GA + +D G+TPL A++ G +E L+ GA V+ + T
Sbjct: 278 ARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKT 337
Query: 215 PLFIAAQEGHTKCVELLLSSGADPDL 240
PL +AA+ GH V LLLS GA P L
Sbjct: 338 PLHLAAERGHGPTVGLLLSRGASPTL 363
Score = 68.6 bits (166), Expect = 1e-11
Identities = 58/179 (32%), Positives = 83/179 (46%), Gaps = 10/179 (5%)
Query: 135 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 194
G G + GW L QA ++ A ++ LLR+GA+ E +D G TPL +A G
Sbjct: 30 GTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPL 89
Query: 195 LSILISSGANVNCQALDKA--TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIH 252
+ +L+ GA V A+D+A T L AA GH++ ELLL GA + P+H
Sbjct: 90 VRLLLQRGAPVG--AVDRAGRTALHEAAWHGHSRVAELLLQRGA--SAAARSGTGLTPLH 145
Query: 253 AAAQMGHT----KILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPD 307
AA +GHT ++L+ P A + + A GG LE+L G D
Sbjct: 146 WAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLD 204
Score = 60.5 bits (145), Expect = 4e-09
Identities = 39/126 (30%), Positives = 60/126 (47%), Gaps = 3/126 (2%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
+ +GLAA G + + LL G + D G +H AA + +Q+L+ +
Sbjct: 238 TALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQGAE--- 294
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLL 131
+ + G LH A+ +GH ++ LL+ GA +AT TPL LA E G + LL
Sbjct: 295 VDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAERGHGPTVGLL 354
Query: 132 LQHGAN 137
L GA+
Sbjct: 355 LSRGAS 360
Score = 47.0 bits (110), Expect = 4e-05
Identities = 30/98 (30%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 12 STVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY 71
S + AA G++ ++ L+ +G VD D G P+H A+ VE L++ +
Sbjct: 271 SALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQ--- 327
Query: 72 IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATT 109
+ + LHLAA +GH V +LL GA P T
Sbjct: 328 VDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRT 365
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 112 bits (281), Expect = 6e-25
Identities = 90/291 (30%), Positives = 137/291 (47%), Gaps = 41/291 (14%)
Query: 17 AAREGNVKVLRKLLKKGR-SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
AAR GN+ +L+ LL GR VD D+ G + AAY ++C++ L+ + I ++
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGAD---INLQ 75
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
G AL AA QGH +V+ L GA T + T L A + G + V+ LL+HG
Sbjct: 76 RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
Query: 136 ANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESL 195
AN++ L GA T LF+AAQ G L+ +
Sbjct: 136 ANIHDQ------------------------LYDGA----------TALFLAAQGGYLDVI 161
Query: 196 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAA 255
+L++SGA VN D PL+IA+Q GH++ V ++L GAD D N+ + L AA
Sbjct: 162 RLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTAL--LKAA 219
Query: 256 QMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSP 306
G+ ++ L+ + N S +++AV G+ + +LL G P
Sbjct: 220 NKGYNDVIKELLKF-SPTLGILKNGTSALHAAVLSGNIKTVALLLEAGADP 269
Score = 84.0 bits (206), Expect = 3e-16
Identities = 64/224 (28%), Positives = 108/224 (48%), Gaps = 37/224 (16%)
Query: 86 AASQGHWKIVQILLEAG-ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSM 144
AA +G+ ++++LL +G D + TT L +A G ID +R L+ GA++N
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRES 78
Query: 145 CGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGAN 204
G +L A+ Q + ++++ L GA+ E + G T L A+QYG ++ + L+ GAN
Sbjct: 79 -GTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGAN 137
Query: 205 VNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILD 264
++ Q D AT LF+AAQ G+ + LLL+SGA + + + P+ A+QMGH+++
Sbjct: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGT--APLWIASQMGHSEV-- 193
Query: 265 LLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILLRNGYSPDA 308
+ ++L G DA
Sbjct: 194 -------------------------------VRVMLLRGADRDA 206
Score = 48.9 bits (115), Expect = 1e-05
Identities = 35/121 (28%), Positives = 58/121 (47%), Gaps = 4/121 (3%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + +A++ G+ +V+R +L +G D A N G + +AA + ++ L+ +
Sbjct: 177 DGTAPLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPT 236
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
+K G ALH A G+ K V +LLEAGADP+ P L + +L
Sbjct: 237 LGILK----NGTSALHAAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNERILRLL 292
Query: 129 R 129
R
Sbjct: 293 R 293
Score = 47.8 bits (112), Expect = 2e-05
Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 38/163 (23%)
Query: 9 DTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSS 68
D + + LAA+ G + V+R LL G V+ G P
Sbjct: 144 DGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAP---------------------- 181
Query: 69 ENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVL 128
L +A+ GH ++V+++L GAD +A + TT L A G DV+
Sbjct: 182 --------------LWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVI 227
Query: 129 RLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGAN 171
+ LL+ + + G ++LH A N + + LLL GA+
Sbjct: 228 KELLKFSPTLGILKN--GTSALHAAVLSGNIKTVALLLEAGAD 268
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 111 bits (277), Expect = 2e-24
Identities = 88/279 (31%), Positives = 127/279 (45%), Gaps = 26/279 (9%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA V V+ LL G V D G +P+H A + E ++L+ +S N +
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
F LH AA++G ++I ++LL+ GADP + TPL L V+ G D+ LL A
Sbjct: 751 FT---PLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL-VKEGDTDIQDLLRGDAA 806
Query: 137 NVNGSHSMC-------------------GWNS--LHQASFQENAEIIKLLLRKGANKECQ 175
++ + C G NS LH A+ N E+ + LL GA+ Q
Sbjct: 807 LLDAAKKGCLARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQ 866
Query: 176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
D G+ PL AA YG ++ ++LI VN TPL AAQ+G T+ LLL+ G
Sbjct: 867 DKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 926
Query: 236 ADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRAC 274
ADP + E L + A A ++D + P C
Sbjct: 927 ADPTMKNQEGQTPLDL-ATADDIRALLIDAMPPEALPTC 964
Score = 97.4 bits (241), Expect = 3e-20
Identities = 83/279 (29%), Positives = 119/279 (42%), Gaps = 59/279 (21%)
Query: 17 AAREGNVKVLRKLLKKGR--SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKM 74
A R G+V +++L+ + D+A + P+H AA + ++ L+ ++ +
Sbjct: 189 ACRNGDVSRVKRLVDAANVNAKDMAGRKS-SPLHFAAGFGRKDVVEHLLQMGAN---VHA 244
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
+ G LH A S GH ++V +LL GADPNA TPL A G+IDV +LLQH
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 135 GANVN---------------------------------------------------GSHS 143
GA+ N H+
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
Query: 144 MCGWNS--LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISS 201
G S LH A+ I++LLL+ GA+ +D G+ PL A YG E +L+
Sbjct: 365 SDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKH 424
Query: 202 GANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
GA VN L + TPL AA + + LLLS GADP L
Sbjct: 425 GACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTL 463
Score = 91.3 bits (225), Expect = 2e-18
Identities = 90/314 (28%), Positives = 143/314 (45%), Gaps = 35/314 (11%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA+ GN + ++++L + + +D + EA+ +E ++ L SS+N + +
Sbjct: 627 AAQMGN-EAVQQILSESTPIRTSDVD--YRLLEASKAGDLETVKQLC---SSQN-VNCRD 679
Query: 77 FEG--FCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
EG LH AA +V+ LL GAD +A PL A G +V LL++H
Sbjct: 680 LEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRH 739
Query: 135 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFV--------- 185
GA+VN + + + LH+A+ + EI KLLL+ GA+ ++ G TPL +
Sbjct: 740 GASVNVA-DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQ 798
Query: 186 -----------AAQYGKLESLSILISSGANVNCQALD--KATPLFIAAQEGHTKCVELLL 232
AA+ G L + L + N+NC+ +TPL +AA + + E LL
Sbjct: 799 DLLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQGRNSTPLHLAAGYNNLEVAEYLL 857
Query: 233 SSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGH 292
GAD + + +P+H AA GH I LLI T +P++ A G
Sbjct: 858 EHGADVN--AQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR 915
Query: 293 EDCLEILLRNGYSP 306
+LL +G P
Sbjct: 916 TQLCALLLAHGADP 929
Score = 90.9 bits (224), Expect = 3e-18
Identities = 84/287 (29%), Positives = 127/287 (44%), Gaps = 44/287 (15%)
Query: 11 CSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSEN 70
C+ L + V L LL+KG +V+ + P+H AA + +++L + N
Sbjct: 528 CAVASLHPKRKQVTEL--LLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
Query: 71 YIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLE-----------------ET 113
+ G ALH AA GH + ++LL G+DP+ +L+ E+
Sbjct: 586 ALDTL---GQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSES 642
Query: 114 TP---------LFLAVENGQIDVLRLLLQHGANVN-----GSHSMCGWNSLHQASFQENA 159
TP L A + G ++ ++ L NVN G HS LH A+
Sbjct: 643 TPIRTSDVDYRLLEASKAGDLETVKQLCS-SQNVNCRDLEGRHS----TPLHFAAGYNRV 697
Query: 160 EIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIA 219
+++ LL GA+ +D G+ PL A YG E +L+ GA+VN L K TPL A
Sbjct: 698 SVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEA 757
Query: 220 AQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLL 266
A +G + +LLL GADP + + L + + G T I DLL
Sbjct: 758 AAKGKYEICKLLLKHGADPTKKNRDGNTPLDL---VKEGDTDIQDLL 801
Score = 85.1 bits (209), Expect = 1e-16
Identities = 79/284 (27%), Positives = 125/284 (44%), Gaps = 64/284 (22%)
Query: 86 AASQGHWKIVQILLEAGADPNATTL--EETTPLFLAVENGQIDVLRLLLQHGANVNGSHS 143
A G V+ L++A A+ NA + +++PL A G+ DV+ LLQ GANV+ +
Sbjct: 189 ACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVH-ARD 246
Query: 144 MCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGA 203
G LH A +AE++ LLL +GA+ +D++ TPL AA GK++ +L+ GA
Sbjct: 247 DGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGA 306
Query: 204 ----------------------------------------------------NVNCQALD 211
NVNC A D
Sbjct: 307 DPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASD 366
Query: 212 --KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPL 269
K+TPL +AA + V+LLL GA D++ + +P+H A GH ++ +LL L
Sbjct: 367 GRKSTPLHLAAGYNRVRIVQLLLQHGA--DVHAKDKGGLVPLHNACSYGHYEVTELL--L 422
Query: 270 TNRACDTGLN--KVSPVYSAVFGGHEDCLEILLRNGYSPDAQAC 311
+ AC ++ + +P++ A + +LL +G P C
Sbjct: 423 KHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNC 466
Score = 58.2 bits (139), Expect = 2e-08
Identities = 40/117 (34%), Positives = 58/117 (49%), Gaps = 6/117 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LAA N++V LL+ G V+ D G +P+H AA + V+ +LI ++ N
Sbjct: 843 LAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDK- 901
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLL 132
F LH AA +G ++ +LL GADP E TPL LA + D+ LL+
Sbjct: 902 --WAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATAD---DIRALLI 953
Score = 48.9 bits (115), Expect = 1e-05
Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 5/127 (3%)
Query: 183 LFVAAQYGKLESLSILISSGANVNCQALD--KATPLFIAAQEGHTKCVELLLSSGADPDL 240
L A + G + + L+ + ANVN + + K++PL AA G VE LL GA+ +
Sbjct: 186 LLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGAN--V 242
Query: 241 YCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
+ +D +P+H A GH +++ LL+ +P++ A G D +LL
Sbjct: 243 HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 302
Query: 301 RNGYSPD 307
++G P+
Sbjct: 303 QHGADPN 309
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 110 bits (276), Expect = 2e-24
Identities = 82/253 (32%), Positives = 129/253 (50%), Gaps = 13/253 (5%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY--IK 73
+AA GN+++L+ L+K+G +DV D G ++ AA H V+ L+ L SEN +
Sbjct: 385 IAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL-----SENKCPLD 439
Query: 74 MKTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
+K G ALH+AA GH + Q+L G++PN EE TPL A +G V + L +
Sbjct: 440 VKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCE 499
Query: 134 HGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLE 193
G NVN + G L AS + +I++ L GA+ D G L +A + ++E
Sbjct: 500 AGCNVNIKNRE-GETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQME 558
Query: 194 SLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHA 253
+ L+S G V+ Q TPL +A ++G+ V L + + D+ + + P+H
Sbjct: 559 VIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDI--SNKYGRTPLHL 616
Query: 254 AAQMGHTKILDLL 266
AA G ILD++
Sbjct: 617 AANNG---ILDVV 626
Score = 87.4 bits (215), Expect = 3e-17
Identities = 73/248 (29%), Positives = 106/248 (42%), Gaps = 37/248 (14%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AAR G+V L+ L + +DV D G M +H AA + + Q+L + S+ N ++
Sbjct: 419 AARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPN---IQD 475
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
E LH AA G++ + + L EAG + N E TPL A G D++ L +HGA
Sbjct: 476 KEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHGA 535
Query: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQD-------------------- 176
++N G +LH A + E+IK LL +G + QD
Sbjct: 536 DLNACDKD-GHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVV 594
Query: 177 -------------DFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEG 223
+G TPL +AA G L+ + L GA+V D T +A E
Sbjct: 595 ALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 654
Query: 224 HTKCVELL 231
H LL
Sbjct: 655 HEHVAGLL 662
Score = 76.3 bits (186), Expect = 6e-14
Identities = 63/234 (26%), Positives = 112/234 (47%), Gaps = 6/234 (2%)
Query: 35 SVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENY-IKMKTFEGFCALHLAASQGHWK 93
++D D+ I A ++V LQ L+ S NY + G L +AA G+ +
Sbjct: 336 TLDEEDSFVMKAIIHAINDDNVPGLQHLLG--SLSNYDVNQPNKHGTPPLLIAAGCGNIQ 393
Query: 94 IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQA 153
I+Q+L++ G+ + + ++ A +G +D L+ L ++ ++ G +LH A
Sbjct: 394 ILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKS-GEMALHVA 452
Query: 154 SFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKA 213
+ +A++ +LL G+N QD TPL AA +G L +G NVN + +
Sbjct: 453 ARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGE 512
Query: 214 TPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLI 267
TPL A+ G+ VE L GAD + C++D + +H A + +++ L+
Sbjct: 513 TPLLTASARGYHDIVECLAEHGADLNA-CDKDG-HIALHLAVRRCQMEVIKTLL 564
Score = 55.1 bits (131), Expect = 2e-07
Identities = 45/199 (22%), Positives = 90/199 (45%), Gaps = 17/199 (8%)
Query: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
G PL +AA G ++ L +LI G+ ++ Q + ++ AA+ GH ++ L +
Sbjct: 379 GTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPL 438
Query: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEI 298
D+ + S ++ +H AA+ GH + LL + + +P++ A + G+ +
Sbjct: 439 DV--KDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKA 496
Query: 299 LLRNGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQIN--------ELHLA 350
L G + + + +P+ A + + IV L ++GA +N LHLA
Sbjct: 497 LCEAGCNVNIKN---REGETPLLTASARG--YHDIVECLAEHGADLNACDKDGHIALHLA 551
Query: 351 YCLKYEKFSIFRYFLRKGC 369
++ + + + L +GC
Sbjct: 552 --VRRCQMEVIKTLLSQGC 568
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 110 bits (276), Expect = 2e-24
Identities = 84/259 (32%), Positives = 124/259 (47%), Gaps = 25/259 (9%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
AA V V+ LL+ G V D G +P+H A + E ++L+ + N +
Sbjct: 533 AAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWK 592
Query: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
F LH AA++G ++I ++LL+ GADP + TPL L V++G D+ LL A
Sbjct: 593 FT---PLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL-VKDGDTDIQDLLRGDAA 648
Query: 137 NVNGSHSMC-------------------GWNS--LHQASFQENAEIIKLLLRKGANKECQ 175
++ + C G +S LH A+ N E+ + LL+ GA+ Q
Sbjct: 649 LLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708
Query: 176 DDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSG 235
D G+ PL AA YG ++ ++LI A VN TPL AAQ+G T+ LLL+ G
Sbjct: 709 DKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHG 768
Query: 236 ADPDLYCNEDSWQLPIHAA 254
ADP L E L + +A
Sbjct: 769 ADPTLKNQEGQTPLDLVSA 787
Score = 99.0 bits (245), Expect = 9e-21
Identities = 86/280 (30%), Positives = 123/280 (43%), Gaps = 61/280 (21%)
Query: 17 AAREGNVKVLRKLL--KKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKM 74
A R G+V+ +++L+ +K S D A + P+H AA + ++ L+ ++ ++
Sbjct: 31 ACRNGDVERVKRLVTPEKVNSRDTAGRKS-TPLHFAAGFGRKDVVEYLLQNGAN---VQA 86
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
+ G LH A S GH ++V +LL GADPNA TPL A G+IDV +LLQH
Sbjct: 87 RDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 146
Query: 135 GA----------------------------------------------------NVNGSH 142
GA NVN H
Sbjct: 147 GAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVN-CH 205
Query: 143 SMCGWNS--LHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILIS 200
+ G S LH A+ +I++LLL+ GA+ +D + PL A YG E +L+
Sbjct: 206 ASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVK 265
Query: 201 SGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDL 240
GA VN L + TPL AA + + LLLS GADP L
Sbjct: 266 HGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTL 305
Score = 97.8 bits (242), Expect = 2e-20
Identities = 91/298 (30%), Positives = 141/298 (47%), Gaps = 33/298 (11%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWM--PIHEAAYHNSVECLQMLINADSSENYIKM 74
AA+ G+V+ ++KL +SV+ D G P+H AA +N V ++ L+ + +
Sbjct: 499 AAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGAD---VHA 554
Query: 75 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 134
K G LH A S GH+++ ++L++ GA N L + TPL A G+ ++ +LLLQH
Sbjct: 555 KDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQH 614
Query: 135 GANVNGSHSMCGWNSLHQASFQENAE-IIKLLLRKGANKECQDDF-GITPLFVAAQYGKL 192
GA+ ++N + L L K + + QD G L AA+ G L
Sbjct: 615 GADPT----------------KKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCL 658
Query: 193 ESLSILISSGANVNCQALD--KATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLP 250
+ L SS NVNC+ +TPL +AA + + E LL GAD + + +P
Sbjct: 659 ARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVN--AQDKGGLIP 715
Query: 251 IHAAAQMGHTKILDLLIPLTNRACDTGLNK--VSPVYSAVFGGHEDCLEILLRNGYSP 306
+H AA GH + LLI AC +K +P++ A G +LL +G P
Sbjct: 716 LHNAASYGHVDVAALLIKY--NACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADP 771
Score = 92.4 bits (228), Expect = 9e-19
Identities = 76/255 (29%), Positives = 120/255 (47%), Gaps = 34/255 (13%)
Query: 83 LHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSH 142
LH AA G +V+ LL+ GA+ A PL A G +V+ LLL+HGA+ N
Sbjct: 62 LHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARD 121
Query: 143 SMCGWN--SLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVA-------------- 186
+ WN LH+A+ + ++ +LL+ GA ++ G T L +A
Sbjct: 122 N---WNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKK 178
Query: 187 ------AQYGKLESLSILISSGANVNCQALD--KATPLFIAAQEGHTKCVELLLSSGADP 238
A+ G E + L++ NVNC A D K+TPL +AA K V+LLL GA
Sbjct: 179 DELLESARSGNEEKMMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGA-- 235
Query: 239 DLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLN--KVSPVYSAVFGGHEDCL 296
D++ + +P+H A GH ++ +LL+ + AC ++ + +P++ A +
Sbjct: 236 DVHAKDKGDLVPLHNACSYGHYEVTELLV--KHGACVNAMDLWQFTPLHEAASKNRVEVC 293
Query: 297 EILLRNGYSPDAQAC 311
+LL G P C
Sbjct: 294 SLLLSYGADPTLLNC 308
Score = 89.7 bits (221), Expect = 6e-18
Identities = 87/339 (25%), Positives = 143/339 (42%), Gaps = 64/339 (18%)
Query: 24 KVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKTFEGFCAL 83
++ LL+KG +++ P+H A+ + +++++ ++ N + G +L
Sbjct: 381 QICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNL---GQTSL 437
Query: 84 HLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHS 143
H AA GH + ++LL G DPN +L+ T L + EN Q LLQ G ++ S +
Sbjct: 438 HRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQ-----QLLQEGISLGNSEA 492
Query: 144 ------------------MCGWNS-------------LHQASFQENAEIIKLLLRKGANK 172
+C S LH A+ +++ LL+ GA+
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Query: 173 ECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
+D G+ PL A YG E +L+ GA VN L K TPL AA +G + +LLL
Sbjct: 553 HAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLL 612
Query: 233 SSGADPDLYCNEDSWQLPIHAAAQMGHTKILDL------LIPLTNRACDTGLNKVS---- 282
GADP + + L + + G T I DL L+ + C + K+S
Sbjct: 613 QHGADPTKKNRDGNTPLDL---VKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDN 669
Query: 283 ------------PVYSAVFGGHEDCLEILLRNGYSPDAQ 309
P++ A + + E LL++G +AQ
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQ 708
Score = 88.2 bits (217), Expect = 2e-17
Identities = 90/324 (27%), Positives = 136/324 (41%), Gaps = 73/324 (22%)
Query: 17 AAREGNVKVLRKLLKK-GRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
+AR GN + + LL + +D R P+H AA +N V+ +Q+L+ + + K
Sbjct: 184 SARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGAD---VHAK 240
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
LH A S GH+++ ++L++ GA NA L + TPL A +++V LLL +G
Sbjct: 241 DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYG 300
Query: 136 AN-----------------------------------------------------VNGSH 142
A+ VN H
Sbjct: 301 ADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH 360
Query: 143 SMCGWNSLHQAS---FQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLSILI 199
+LH A+ + + +I +LLLRKGAN + +TPL VA++ + + +++
Sbjct: 361 PQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVV 420
Query: 200 SSGANVNCQALDK--ATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQM 257
A VN ALD T L AA GH + LLLS G DP++ L A QM
Sbjct: 421 KHEAKVN--ALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNII------SLQGFTALQM 472
Query: 258 GHTKILDLL---IPLTNRACDTGL 278
G+ + LL I L N D L
Sbjct: 473 GNENVQQLLQEGISLGNSEADRQL 496
Score = 75.9 bits (185), Expect = 8e-14
Identities = 67/243 (27%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLI---------NADS 67
A G+ +V L+K G V+VAD + P+HEAA E ++L+ N D
Sbjct: 566 ACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDG 625
Query: 68 SENYIKMKT--------FEGFCALHLAASQGHWKIVQILLEA-GADPNATTLEETTPLFL 118
+ +K G AL AA +G V+ L + T +TPL L
Sbjct: 626 NTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHL 685
Query: 119 AVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDF 178
A ++V LLQHGA+VN + G LH A+ + ++ LL++ A D +
Sbjct: 686 AAGYNNLEVAEYLLQHGADVN-AQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKW 744
Query: 179 GITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADP 238
TPL AAQ G+ + ++L++ GA+ + + TPL + + + + + + A P
Sbjct: 745 AFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALP 804
Query: 239 DLY 241
Y
Sbjct: 805 SCY 807
Score = 68.2 bits (165), Expect = 2e-11
Identities = 83/310 (26%), Positives = 137/310 (44%), Gaps = 40/310 (12%)
Query: 116 LFLAVENGQID-VLRLLLQHGANVNGSHSMCGWNS--LHQASFQENAEIIKLLLRKGANK 172
LF A NG ++ V RL+ N S G S LH A+ ++++ LL+ GAN
Sbjct: 28 LFEACRNGDVERVKRLVTPEKVN---SRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
Query: 173 ECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
+ +DD G+ PL A +G E +++L+ GA+ N + TPL AA +G +LL
Sbjct: 85 QARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 144
Query: 233 SSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGH 292
GA+P + N D G T LDL P + +A TG K + + G+
Sbjct: 145 QHGAEPTIR-NTD------------GRT-ALDLADP-SAKAVLTGEYKKDELLESARSGN 189
Query: 293 EDCLEILLR----NGYSPDAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGAQINE-- 346
E+ + LL N ++ D + S+P+ +A IV +LL++GA ++
Sbjct: 190 EEKMMALLTPLNVNCHASDGRK------STPLHLA--AGYNRVKIVQLLLQHGADVHAKD 241
Query: 347 ----LHLAYCLKYEKFSIFRYFLRKGCSLGPWNHIYEFVNHAIKAQAKYKEWLPHLLVAG 402
+ L Y + + ++ G + + +++F A E LL G
Sbjct: 242 KGDLVPLHNACSYGHYEVTELLVKHGACVNAMD-LWQFTPLHEAASKNRVEVCSLLLSYG 300
Query: 403 FDPLILLCNS 412
DP +L C++
Sbjct: 301 ADPTLLNCHN 310
Score = 55.8 bits (133), Expect = 9e-08
Identities = 36/103 (34%), Positives = 51/103 (49%), Gaps = 3/103 (2%)
Query: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
LAA N++V LL+ G V+ D G +P+H AA + V+ +LI ++ N
Sbjct: 685 LAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDK- 743
Query: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFL 118
F LH AA +G ++ +LL GADP E TPL L
Sbjct: 744 --WAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,215,565
Number of Sequences: 37866
Number of extensions: 834605
Number of successful extensions: 6988
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 344
Number of HSP's successfully gapped in prelim test: 56
Number of HSP's that attempted gapping in prelim test: 1522
Number of HSP's gapped (non-prelim): 1959
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.