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Search of human proteins with 7705308
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7705308 growth differentiation factor 2 [Homo sapiens]
(429 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7705308 growth differentiation factor 2 [Homo sapiens] 877 0.0
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 300 1e-81
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 144 2e-34
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 144 2e-34
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 144 2e-34
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 144 2e-34
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 133 3e-31
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 129 5e-30
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 125 6e-29
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 123 4e-28
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 122 5e-28
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 121 1e-27
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 119 5e-27
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 115 8e-26
gi|222352098 nodal precursor [Homo sapiens] 112 6e-25
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 96 6e-20
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 94 3e-19
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 92 9e-19
gi|110349792 growth differentiation factor 1 [Homo sapiens] 92 1e-18
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 91 2e-18
gi|4504699 inhibin beta A precursor [Homo sapiens] 79 6e-15
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 77 4e-14
gi|13899338 activin beta E [Homo sapiens] 73 6e-13
gi|4885259 myostatin [Homo sapiens] 72 1e-12
gi|153792495 growth differentiation factor 15 [Homo sapiens] 69 1e-11
gi|239757187 PREDICTED: similar to growth differentiation factor... 69 1e-11
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 67 2e-11
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 65 2e-10
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 61 2e-09
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 56 7e-08
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 877 bits (2266), Expect = 0.0
Identities = 429/429 (100%), Positives = 429/429 (100%)
Query: 1 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE 60
MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE
Sbjct: 1 MCPGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLE 60
Query: 61 NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI 120
NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI
Sbjct: 61 NVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISI 120
Query: 121 TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD 180
TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD
Sbjct: 121 TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTD 180
Query: 181 AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL 240
AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL
Sbjct: 181 AWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTL 240
Query: 241 DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH 300
DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH
Sbjct: 241 DISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSH 300
Query: 301 EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC 360
EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC
Sbjct: 301 EEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGC 360
Query: 361 FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG 420
FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG
Sbjct: 361 FFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEG 420
Query: 421 MSVAECGCR 429
MSVAECGCR
Sbjct: 421 MSVAECGCR 429
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 300 bits (769), Expect = 1e-81
Identities = 168/378 (44%), Positives = 243/378 (64%), Gaps = 15/378 (3%)
Query: 59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAI 118
L+++K +FL++LNLS +P+QD +V+PP+YM++LYN++ +D+++ P++NI+RSF ED
Sbjct: 55 LQSMKDEFLKTLNLSDIPTQDSAKVDPPEYMLELYNKFATDRTSMPSANIIRSFKNEDLF 114
Query: 119 SITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDG 178
S + + +K+ LLFN+SIP HE++ AELRLY Q + + I++VL+
Sbjct: 115 SQPVSFN-GLRKYPLLFNVSIPHHEEVIMAELRLYTLVQRDRMIYDGVDRKITIFEVLES 173
Query: 179 TDAWDSATETKTFLVSQDIQ--DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVES-HRK 235
+ LVS +I + WET +V+ A++RW +S S S ++LEV +ES H +
Sbjct: 174 KGD-NEGERNMLVLVSGEIYGTNSEWETFDVTDAIRRWQKSGS--STHQLEVHIESKHDE 230
Query: 236 GCDT----LDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDG 291
D L+I +++ P +VFS+D SS KE + EL EMISHEQ L L D
Sbjct: 231 AEDASSGRLEIDTSAQNKHNPLLIVFSDDQSSD-KERKEELNEMISHEQLPELDNLGLDS 289
Query: 292 STEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEY 351
+ ++ ST AR +R+A G++C++T L ++F++IGWDSWIIAP Y
Sbjct: 290 FSSGPGEEALLQMRSNIIYDST-ARIRRNA-KGNYCKRTPLYIDFKEIGWDSWIIAPPGY 347
Query: 352 EAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGV 411
EAYEC+G C +PLA+ +TPTKHAI+Q LVHLK K KACCVPTKL PIS+LY D GV
Sbjct: 348 EAYECRGVCNYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYL-DKGV 406
Query: 412 PTLKYHYEGMSVAECGCR 429
T K+ YEGM+V+ECGCR
Sbjct: 407 VTYKFKYEGMAVSECGCR 424
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 144 bits (363), Expect = 2e-34
Identities = 130/403 (32%), Positives = 183/403 (45%), Gaps = 80/403 (19%)
Query: 59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTT------------PAS 106
L + + L+ L P K+ V P YM DLY + ++ PAS
Sbjct: 54 LRDFEATLLQMFGLRRRPQPSKSAVIP-DYMRDLYRLQSGEEEEEQIHSTGLEYPERPAS 112
Query: 107 --NIVRSFSMEDAI-SITAT-EDFPFQKHILLFNIS-IPRHEQITRAELRLYVSCQNHVD 161
N VRSF E+ + +I T E+ F+ LFN+S IP +E I+ AELRL+ + VD
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFR---FLFNLSSIPENEVISSAELRLF---REQVD 166
Query: 162 PSHDLKGS---VVIYDVLDG-TDAWDSATETK---TFLVSQDIQDEGWETLEVSSAVKRW 214
D + + IY+V+ + T+ T LV ++ WET +VS AV RW
Sbjct: 167 QGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTR--WETFDVSPAVLRW 224
Query: 215 VRSDSTKSKNKLEVT----VESHRKGCDTLDISVPPGSRNL----PFFVVFSNDHSSGTK 266
R +EVT +H+ + S+P GS N P V F +D
Sbjct: 225 TREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHAL 284
Query: 267 ETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSH 326
R + H + AR+K +
Sbjct: 285 TRRRRAKRSPKHHSQR--------------------------------ARKKNK-----N 307
Query: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPT 386
C++ SL V+F D+GW+ WI+AP Y+A+ C G C FPLAD + T HAIVQTLV+ +
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNS 366
Query: 387 KVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
+ KACCVPT+LS IS+LY D+ LK +Y+ M V CGCR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLK-NYQEMVVEGCGCR 408
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 144 bits (363), Expect = 2e-34
Identities = 130/403 (32%), Positives = 183/403 (45%), Gaps = 80/403 (19%)
Query: 59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTT------------PAS 106
L + + L+ L P K+ V P YM DLY + ++ PAS
Sbjct: 54 LRDFEATLLQMFGLRRRPQPSKSAVIP-DYMRDLYRLQSGEEEEEQIHSTGLEYPERPAS 112
Query: 107 --NIVRSFSMEDAI-SITAT-EDFPFQKHILLFNIS-IPRHEQITRAELRLYVSCQNHVD 161
N VRSF E+ + +I T E+ F+ LFN+S IP +E I+ AELRL+ + VD
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFR---FLFNLSSIPENEVISSAELRLF---REQVD 166
Query: 162 PSHDLKGS---VVIYDVLDG-TDAWDSATETK---TFLVSQDIQDEGWETLEVSSAVKRW 214
D + + IY+V+ + T+ T LV ++ WET +VS AV RW
Sbjct: 167 QGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTR--WETFDVSPAVLRW 224
Query: 215 VRSDSTKSKNKLEVT----VESHRKGCDTLDISVPPGSRNL----PFFVVFSNDHSSGTK 266
R +EVT +H+ + S+P GS N P V F +D
Sbjct: 225 TREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHAL 284
Query: 267 ETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSH 326
R + H + AR+K +
Sbjct: 285 TRRRRAKRSPKHHSQR--------------------------------ARKKNK-----N 307
Query: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPT 386
C++ SL V+F D+GW+ WI+AP Y+A+ C G C FPLAD + T HAIVQTLV+ +
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNS 366
Query: 387 KVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
+ KACCVPT+LS IS+LY D+ LK +Y+ M V CGCR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLK-NYQEMVVEGCGCR 408
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 144 bits (363), Expect = 2e-34
Identities = 130/403 (32%), Positives = 183/403 (45%), Gaps = 80/403 (19%)
Query: 59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTT------------PAS 106
L + + L+ L P K+ V P YM DLY + ++ PAS
Sbjct: 54 LRDFEATLLQMFGLRRRPQPSKSAVIP-DYMRDLYRLQSGEEEEEQIHSTGLEYPERPAS 112
Query: 107 --NIVRSFSMEDAI-SITAT-EDFPFQKHILLFNIS-IPRHEQITRAELRLYVSCQNHVD 161
N VRSF E+ + +I T E+ F+ LFN+S IP +E I+ AELRL+ + VD
Sbjct: 113 RANTVRSFHHEEHLENIPGTSENSAFR---FLFNLSSIPENEVISSAELRLF---REQVD 166
Query: 162 PSHDLKGS---VVIYDVLDG-TDAWDSATETK---TFLVSQDIQDEGWETLEVSSAVKRW 214
D + + IY+V+ + T+ T LV ++ WET +VS AV RW
Sbjct: 167 QGPDWERGFHRINIYEVMKPPAEVVPGHLITRLLDTRLVHHNVTR--WETFDVSPAVLRW 224
Query: 215 VRSDSTKSKNKLEVT----VESHRKGCDTLDISVPPGSRNL----PFFVVFSNDHSSGTK 266
R +EVT +H+ + S+P GS N P V F +D
Sbjct: 225 TREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHAL 284
Query: 267 ETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSH 326
R + H + AR+K +
Sbjct: 285 TRRRRAKRSPKHHSQR--------------------------------ARKKNK-----N 307
Query: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPT 386
C++ SL V+F D+GW+ WI+AP Y+A+ C G C FPLAD + T HAIVQTLV+ +
Sbjct: 308 CRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVN-SVNS 366
Query: 387 KVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
+ KACCVPT+LS IS+LY D+ LK +Y+ M V CGCR
Sbjct: 367 SIPKACCVPTELSAISMLYLDEYDKVVLK-NYQEMVVEGCGCR 408
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 144 bits (362), Expect = 2e-34
Identities = 116/381 (30%), Positives = 173/381 (45%), Gaps = 57/381 (14%)
Query: 67 LRSLNLSGV---PSQDKTRVEPPQYMIDLYNRYTSDKSTTPA-----------SNIVRSF 112
LR L++ G+ P+ + V PP YM+DLY R+ S + +PA +N VRSF
Sbjct: 55 LRLLSMFGLKQRPTPSRDAVVPP-YMLDLYRRH-SGQPGSPAPDHRLERAASRANTVRSF 112
Query: 113 SMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLY-VSCQNHVDPSHDLKGSVV 171
E+++ + SIP E IT AEL+++ Q+ + + +
Sbjct: 113 HHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRIN 172
Query: 172 IYDVLDGTDAWDSATETK---TFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEV 228
IY+++ A T+ T LV+Q+ WE+ +V+ AV RW +EV
Sbjct: 173 IYEIIKPATANSKFPVTRLLDTRLVNQNASR--WESFDVTPAVMRWTAQGHANHGFVVEV 230
Query: 229 TVESHRKGCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLS 288
++G + + SR+L H + L
Sbjct: 231 AHLEEKQGVSKRHVRI---SRSL----------------------HQDEHSWSQIRPLLV 265
Query: 289 KDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAP 348
G G H+ + A+ K+ S C++ L V+F D+GW+ WI+AP
Sbjct: 266 TFGHDGKGHPLHKRE--------KRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAP 317
Query: 349 KEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDD 408
Y A+ C G C FPLAD + T HAIVQTLV+ +K+ KACCVPT+LS IS+LY D+
Sbjct: 318 PGYHAFYCHGECPFPLADHLNSTNHAIVQTLVN-SVNSKIPKACCVPTELSAISMLYLDE 376
Query: 409 MGVPTLKYHYEGMSVAECGCR 429
LK +Y+ M V CGCR
Sbjct: 377 NEKVVLK-NYQDMVVEGCGCR 396
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 133 bits (335), Expect = 3e-31
Identities = 116/384 (30%), Positives = 171/384 (44%), Gaps = 55/384 (14%)
Query: 82 RVEPPQYMIDLYNRYT---------SDKSTTPASNIVRSFSMEDAISITATEDFPFQKHI 132
RV P +YM+ +Y Y+ S ++ ++N + SF ++ T P ++
Sbjct: 91 RVVPHEYMLSIYRTYSIAEKLGINASFFQSSKSANTITSFVDRGLDDLSHT---PLRRQK 147
Query: 133 LLFNIS-IPRHEQITRAELRLYVSCQN----------HVDPSHDLKGSVVIYDVLDGTDA 181
LF++S + E++ AELRL+ + HV L ++ LD A
Sbjct: 148 YLFDVSMLSDKEELVGAELRLFRQAPSAPWGPPAGPLHVQLFPCLSPLLLDARTLDPQGA 207
Query: 182 WDSATETKTFLVSQDIQDEGWETL--EVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDT 239
+ E F V Q ++ + W+ L E+ +A W D+ +++ + + +
Sbjct: 208 PPAGWEV--FDVWQGLRHQPWKQLCLELRAA---WGELDAGEAEARARGPQQPPPPDLRS 262
Query: 240 LDISV---PPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAG 296
L PP R L VVF+ S K E+RE + + + E
Sbjct: 263 LGFGRRVRPPQERAL--LVVFTR---SQRKNLFAEMREQLGSAEAA-----GPGAGAEGS 312
Query: 297 ESSHEEDTDGHVAAGSTLARRKRSAGAGSH-----------CQKTSLRVNFEDIGWDSWI 345
D S RR+R+A A H C K L VNF+++GWD WI
Sbjct: 313 WPPPSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWI 372
Query: 346 IAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLY 405
IAP EYEAY C+G C FPL + PT HAI+QTL++ P +CCVPTKL+PIS+LY
Sbjct: 373 IAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGSTPPSCCVPTKLTPISILY 432
Query: 406 KDDMGVPTLKYHYEGMSVAECGCR 429
D G + YE M V CGCR
Sbjct: 433 -IDAGNNVVYKQYEDMVVESCGCR 455
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 129 bits (324), Expect = 5e-30
Identities = 102/312 (32%), Positives = 133/312 (42%), Gaps = 39/312 (12%)
Query: 127 PFQKHI--LLFNIS-IPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWD 183
P Q+H FN+S IP E +T AE R+Y C + + + IY VL D
Sbjct: 230 PRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCV--MGSFKNQTFLISIYQVLQEHQHRD 287
Query: 184 SATETKTFLVSQDI---QDEGWETLEVSSAVKRWVRSDSTKSKNKLEVT----VESHRKG 236
S FL+ + +EGW ++++ WV + +L V V H +
Sbjct: 288 S----DLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGVHVHPRA 343
Query: 237 CDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAG 296
+ P + PF V F + TR S+
Sbjct: 344 AGLVGRDGPYDKQ--PFMVAFFKVSEVHVRTTR--------------------SASSRRR 381
Query: 297 ESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYEC 356
+ S T A + A S+ + C+K L V+F+D+GW WIIAPK Y A C
Sbjct: 382 QQSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYC 441
Query: 357 KGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKY 416
G C FPL + T HAIVQTLVHL P V K CC PTKL+ ISVLY DD LK
Sbjct: 442 DGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILK- 500
Query: 417 HYEGMSVAECGC 428
Y M V CGC
Sbjct: 501 KYRNMVVRACGC 512
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 125 bits (315), Expect = 6e-29
Identities = 93/294 (31%), Positives = 130/294 (44%), Gaps = 31/294 (10%)
Query: 139 IPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQ 198
IP E +T AE R+Y N+ + +K + IY ++ D+ +Q +
Sbjct: 187 IPHGEAVTAAEFRIYKDRSNNRFENETIK--ISIYQIIKEYTNRDADLFLLDTRKAQAL- 243
Query: 199 DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHR----KGCDTLDISVPPGSRNLPFF 254
D GW +++ WV + +L R K + P + PF
Sbjct: 244 DVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQ--PFM 301
Query: 255 VVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTL 314
V F K + + LR + + +K + +SS +D+ + G
Sbjct: 302 VAFF-------KASEVLLRSV---------RAANKRKNQNRNKSSSHQDSSRMSSVGDYN 345
Query: 315 ARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHA 374
++ A C+K L V+F D+GW WIIAP+ Y A+ C G C FPL + T HA
Sbjct: 346 TSEQKQA-----CKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHA 400
Query: 375 IVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
IVQTLVHL FP V K CC PTKL+ ISVLY DD LK Y M V CGC
Sbjct: 401 IVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILK-KYRNMVVRSCGC 453
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 123 bits (308), Expect = 4e-28
Identities = 124/454 (27%), Positives = 167/454 (36%), Gaps = 85/454 (18%)
Query: 3 PGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENV 62
PG LW L G L + G G G P G P+ + +V
Sbjct: 5 PGPLW------------LLGLALCALGGGGPGLR-------PPPGCPQRRLGARE-RRDV 44
Query: 63 KVDFLRSLNLSG------VPSQDKTRVEPPQYMIDLYNRYTSDKSTTPA--------SNI 108
+ + L L L G P+ + P +M+DLY+ D A +++
Sbjct: 45 QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADL 104
Query: 109 VRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKG 168
V SF P K IP E +T AE R+Y PS L
Sbjct: 105 VMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKV------PSIHLLN 158
Query: 169 SVVIYDVLDGTDAWDSATETKTFLVSQDIQ--DEGWETLEVSSAVKRWVRSDSTKSKNKL 226
+ + + FL Q ++ DEGW L+V++A W+ +L
Sbjct: 159 RTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL 218
Query: 227 EVTVESHRKGCDTLDISVPPGSRNL----------PFFVVFSNDHSSGTKETRL--ELRE 274
V E SV PG L PF V F S + R LR
Sbjct: 219 YVETEDGH--------SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPRAVRPLRR 270
Query: 275 MISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRV 334
+ + + G + SH C++ L V
Sbjct: 271 RQPKKSNELPQANRLPGIFDDVHGSHGRQV----------------------CRRHELYV 308
Query: 335 NFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCV 394
+F+D+GW W+IAP+ Y AY C+G C FPL + T HAI+Q+LVHL P V KACC
Sbjct: 309 SFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPDAVPKACCA 368
Query: 395 PTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
PTKLS SVLY D L+ H M V CGC
Sbjct: 369 PTKLSATSVLYYDSSNNVILRKH-RNMVVKACGC 401
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 122 bits (307), Expect = 5e-28
Identities = 123/452 (27%), Positives = 169/452 (37%), Gaps = 81/452 (17%)
Query: 3 PGALWVALPLLSLLAGSLQGKPLQSWGRGSAGGNAHSPLGVPGGGLPEHTFNLKMFLENV 62
PG LW L G L + G G G P G P+ + +V
Sbjct: 5 PGPLW------------LLGLTLCALGGGGPGLR-------PPPGCPQRRLGARE-RRDV 44
Query: 63 KVDFLRSLNLSG------VPSQDKTRVEPPQYMIDLYNRYTSDKSTTPA--------SNI 108
+ + L L L G P+ + P +M+DLY+ D A +++
Sbjct: 45 QREILAVLGLPGRPRPRAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAEQRLGRADL 104
Query: 109 VRSFSMEDAISITATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKG 168
V SF P K IP E +T AE R+Y PS L
Sbjct: 105 VMSFVNMVERDRALGHQEPHWKEFRFDLTQIPAGEAVTAAEFRIYKV------PSIHLLN 158
Query: 169 SVVIYDVLDGTDAWDSATETKTFLVSQDIQ--DEGWETLEVSSAVKRWVRSDSTKSKNKL 226
+ + + FL Q ++ DEGW L+V++A W+ +L
Sbjct: 159 RTLHVSMFQVVQEQSNRESDLFFLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRL 218
Query: 227 EVTVESHRKGCDTLDISVPPGSRNL----------PFFVVFSNDHSSGTKETRLELREMI 276
V E SV PG L PF V F S + R
Sbjct: 219 YVETEDGH--------SVDPGLAGLLGQRAPRSQQPFVVTFFRASPSPIRTPR------- 263
Query: 277 SHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNF 336
++ L + ++ E G + R + C++ L V+F
Sbjct: 264 ------AVRPLRRRQPKKSNELPQANRLPG-------IFDDVRGSHGRQVCRRHELYVSF 310
Query: 337 EDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPT 396
+D+GW W+IAP+ Y AY C+G C FPL + T HAI+Q+LVHL P V KACC PT
Sbjct: 311 QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMKPNAVPKACCAPT 370
Query: 397 KLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
KLS SVLY D L+ H M V CGC
Sbjct: 371 KLSATSVLYYDSSNNVILRKH-RNMVVKACGC 401
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 121 bits (304), Expect = 1e-27
Identities = 115/400 (28%), Positives = 174/400 (43%), Gaps = 69/400 (17%)
Query: 70 LNLSGVPSQDKTRVE-----PPQYMIDLYNR-----------------YTSDKSTT--PA 105
L++ G+P + + ++ P +M+DLYN Y + ST P
Sbjct: 59 LSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEEGGGPGGQGFSYPYKAVFSTQGPPL 118
Query: 106 SNIVRSFSMEDAISITA--------TEDFPFQKHILLFNIS---IPRHEQITRAELRLYV 154
+++ S + DA + + E F + H F IP E +T AE R+Y
Sbjct: 119 ASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIY- 177
Query: 155 SCQNHVDPSHDLKG-SVVIYDVLD---GTDAWDSATETKTFLVSQDIQDEGWETLEVSSA 210
++++ D + + +Y VL G ++ +++T S+ EGW ++++
Sbjct: 178 --KDYIRERFDNETFRISVYQVLQEHLGRESDLFLLDSRTLWASE----EGWLVFDITAT 231
Query: 211 VKRWVRSDSTKSKNKLEV-TVESHRKGCDTLDISVPPGSRNL-PFFVVFSNDHSSGTKET 268
WV + +L V T++ + G +N PF V F K T
Sbjct: 232 SNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFF-------KAT 284
Query: 269 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQ 328
+ R + S + + SK + E +VA S+ +R+ C+
Sbjct: 285 EVHFRSIRSTGSKQRSQNRSKTPKNQ------EALRMANVAENSSSDQRQA-------CK 331
Query: 329 KTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKV 388
K L V+F D+GW WIIAP+ Y AY C+G C FPL + T HAIVQTLVH P V
Sbjct: 332 KHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPETV 391
Query: 389 GKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
K CC PT+L+ ISVLY DD LK Y M V CGC
Sbjct: 392 PKPCCAPTQLNAISVLYFDDSSNVILK-KYRNMVVRACGC 430
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 119 bits (298), Expect = 5e-27
Identities = 55/118 (46%), Positives = 73/118 (61%), Gaps = 1/118 (0%)
Query: 312 STLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPT 371
+T ++ S + C + +L VNF+D+GWD WIIAP EYEA+ C+G C FPL + PT
Sbjct: 385 ATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPT 444
Query: 372 KHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
HA++QTL++ P CCVPT+LSPIS+L+ D K YE M V CGCR
Sbjct: 445 NHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYK-QYEDMVVESCGCR 501
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 115 bits (288), Expect = 8e-26
Identities = 58/120 (48%), Positives = 72/120 (60%), Gaps = 6/120 (5%)
Query: 310 AGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVT 369
AG RR RS C + L V+F+++GWD WIIAP +YEAY C+G C FPL +
Sbjct: 337 AGRGHGRRGRS-----RCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLE 391
Query: 370 PTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
PT HAI+QTL++ P +CCVP +LSPIS+LY D K YE M V CGCR
Sbjct: 392 PTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYK-QYEDMVVEACGCR 450
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 112 bits (280), Expect = 6e-25
Identities = 102/364 (28%), Positives = 144/364 (39%), Gaps = 51/364 (14%)
Query: 70 LNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQ 129
L G PS P YM+ LY + P ++I+RS ED F F
Sbjct: 29 LRTRGQPSSPS----PLAYMLSLY------RDPLPRADIIRSLQAEDVAVDGQNWTFAFD 78
Query: 130 KHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETK 189
L + E + AELRL +S + L + D A DS E
Sbjct: 79 FSFL------SQQEDLAWAELRLQLSSPVDLPTEGSLAIEIFHQPKPDTEQASDSCLERF 132
Query: 190 -----TFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISV 244
T +SQ G LEV+ + +W++ K V E +
Sbjct: 133 QMDLFTVTLSQVTFSLGSMVLEVTRPLSKWLKHPGALEKQMSRVAGECWPRP------PT 186
Query: 245 PPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEAGESSHEEDT 304
PP + L +S+ ++E R + E ES + S E G+
Sbjct: 187 PPATNVLLML------YSNLSQEQRQLGGSTLLWEAESSWRAQEGQLSWEWGKRH----- 235
Query: 305 DGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPL 364
RR C+K +V+F IGW SWII PK+Y AY C+G C P+
Sbjct: 236 -----------RRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPV 284
Query: 365 ADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVA 424
++ PT HA +Q+L+ P +V CC P K P+S+LY D+ V L H++ M V
Sbjct: 285 GEEFHPTNHAYIQSLLKRYQPHRVPSTCCAPVKTKPLSMLYVDNGRV--LLDHHKDMIVE 342
Query: 425 ECGC 428
ECGC
Sbjct: 343 ECGC 346
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 95.9 bits (237), Expect = 6e-20
Identities = 47/102 (46%), Positives = 64/102 (62%), Gaps = 2/102 (1%)
Query: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPT 386
C + L +NF D+GW WIIAPK + A C G C F L + + +A +Q L+H P
Sbjct: 264 CHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVDP- 322
Query: 387 KVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
++ +A C+PTKLSPIS+LY+D+ L+ HYE M V ECGC
Sbjct: 323 EIPQAVCIPTKLSPISMLYQDNNDNVILR-HYEDMVVDECGC 363
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 93.6 bits (231), Expect = 3e-19
Identities = 42/105 (40%), Positives = 64/105 (60%), Gaps = 2/105 (1%)
Query: 326 HCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVH-LKF 384
+C + L+V+F DIGW WII+PK ++AY C G C FP+ + P+ HA +Q++V +
Sbjct: 369 NCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGV 428
Query: 385 PTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
+ + CCVP K+S +S+L+ D+ LK Y M+V C CR
Sbjct: 429 VPGIPEPCCVPEKMSSLSILFFDENKNVVLKV-YPNMTVESCACR 472
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 92.0 bits (227), Expect = 9e-19
Identities = 43/104 (41%), Positives = 63/104 (60%), Gaps = 2/104 (1%)
Query: 327 CQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVH-LKFP 385
C + L+V+F DIGW+ WII+PK ++AY C G C FP+ V P+ HA +Q++V +
Sbjct: 376 CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGII 435
Query: 386 TKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
+ + CCVP K++ + VL+ D+ LK Y MSV C CR
Sbjct: 436 PGIPEPCCVPDKMNSLGVLFLDENRNVVLKV-YPNMSVDTCACR 478
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 91.7 bits (226), Expect = 1e-18
Identities = 50/126 (39%), Positives = 68/126 (53%), Gaps = 11/126 (8%)
Query: 314 LARRKRSA------GAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLA-- 365
LAR +R A G G C+ L V+F ++GW W+IAP+ + A C+G C P+A
Sbjct: 248 LARPRRDAEPVLGGGPGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALS 307
Query: 366 --DDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSV 423
HA+++ L+H P CCVP +LSPISVL+ D+ L+ YE M V
Sbjct: 308 GSGGPPALNHAVLRALMHAAAPGAADLPCCVPARLSPISVLFFDNSDNVVLR-QYEDMVV 366
Query: 424 AECGCR 429
ECGCR
Sbjct: 367 DECGCR 372
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 90.9 bits (224), Expect = 2e-18
Identities = 84/352 (23%), Positives = 145/352 (41%), Gaps = 36/352 (10%)
Query: 87 QYMIDLYNRYTSDKSTTPASNIVRSFSMEDAISITATEDFPFQK--HILLFNISIPRHEQ 144
+YM++LY R ++D P N +M + + P + HI + +
Sbjct: 68 RYMLELYRR-SADSHGHPRENRTIGATMVRLVKPLTSVARPHRGTWHIQILGFPL----- 121
Query: 145 ITRAELRLYVSCQNHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQ------DIQ 198
R LY + V H L+ + +++ + W T F S+ +
Sbjct: 122 --RPNRGLYQLVRATVVYRHHLQ--LTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLM 177
Query: 199 DEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRKGCDTLDISVPPGSRNLPFFVVFS 258
W+ ++++ V++ ++ +L + +K L++ S ++ F +++
Sbjct: 178 SNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQ-QKDSGGLELWHGTSSLDIAFLLLYF 236
Query: 259 NDHSSGTKETRLELREMISH-EQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARR 317
ND ++ + R M E+ES+L++ + DG ++A T +
Sbjct: 237 NDTHKSIRKAKFLPRGMEEFMERESLLRRTRQ--------------ADG-ISAEVTASSS 281
Query: 318 KRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQ 377
K S + C +++F +GWD WIIAP Y CKG C L D + HAI+Q
Sbjct: 282 KHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQ 341
Query: 378 TLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
L++ V + CVP K PISVL + G L YEGM C CR
Sbjct: 342 NLINQLVDQSVPRPSCVPYKYVPISVLMIEANG-SILYKEYEGMIAESCTCR 392
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 79.3 bits (194), Expect = 6e-15
Identities = 54/156 (34%), Positives = 71/156 (45%), Gaps = 17/156 (10%)
Query: 289 KDGSTEAGESSHEEDTDGH---------VAAGSTLARRKRSA---GAGSHCQKTSLRVNF 336
K G E G + EE H + RR+R G + C K V+F
Sbjct: 271 KKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKVNICCKKQFFVSF 330
Query: 337 EDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKF----PTKVGKAC 392
+DIGW+ WIIAP Y A C+G C +A + + H + P K+C
Sbjct: 331 KDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSC 390
Query: 393 CVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
CVPTKL P+S+LY DD G +K + M V ECGC
Sbjct: 391 CVPTKLRPMSMLYYDD-GQNIIKKDIQNMIVEECGC 425
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 76.6 bits (187), Expect = 4e-14
Identities = 54/195 (27%), Positives = 80/195 (41%), Gaps = 18/195 (9%)
Query: 252 PFFVVFSNDHSSGTKETRLEL----REMISHEQESVLKKLSK-DGSTEAGESSHEEDTDG 306
P +++ ND S+ + L R +QE L + + E G SSH G
Sbjct: 261 PSLILYLNDTSAQAYHSWYSLHYKRRPSQGPDQERSLSAYPVGEEAAEDGRSSHHRHRRG 320
Query: 307 HVAAGSTLARRKRSAGAG------------SHCQKTSLRVNFEDIGWDSWIIAPKEYEAY 354
S L + A + C+ R++F + WD+WI+AP Y
Sbjct: 321 QETVSSELKKPLGPASFNLSEYFRQFLLPQNECELHDFRLSFSQLKWDNWIVAPHRYNPR 380
Query: 355 ECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTL 414
CKG C + H +VQ +++ K + V + CVP K SP+SVL + G
Sbjct: 381 YCKGDCPRAVGHRYGSPVHTMVQNIIYEKLDSSVPRPSCVPAKYSPLSVLTIEPDGSIAY 440
Query: 415 KYHYEGMSVAECGCR 429
K YE M +C CR
Sbjct: 441 K-EYEDMIATKCTCR 454
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 72.8 bits (177), Expect = 6e-13
Identities = 94/375 (25%), Positives = 141/375 (37%), Gaps = 70/375 (18%)
Query: 57 MFLENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNRYTSDKSTTPASNIVRSFSMED 116
+ LE K L L+L+ P + PPQ + R S P + E+
Sbjct: 42 LVLELAKQQILDGLHLTSRP---RITHPPPQAALTRALRRLQPGSVAPGNG-------EE 91
Query: 117 AISI-TATEDFPFQKHILLFNISIPRHEQITRAELRLYVSCQNHVDPSHDLKGSVVIYDV 175
IS T T+ +L F++S PR + A L L HV P+ L G++ +
Sbjct: 92 VISFATVTDSTSAYSSLLTFHLSTPRSHHLYHARLWL------HVLPT--LPGTLCLRIF 143
Query: 176 LDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKNKLEVTVESHRK 235
G + +T L I + GW TL + S+ R +S K
Sbjct: 144 RWGPRRRRQGS--RTLLAEHHITNLGWHTLTLPSSGLRGEKSGVLK-------------- 187
Query: 236 GCDTLDISVPPGSRNLPFFVVFSNDHSSGTKETRLELREMISHEQESVLKKLSKDGSTEA 295
L + P N S+ T + R L + H+Q + K+ + E
Sbjct: 188 ----LQLDCRPLEGN-----------STVTGQPR-RLLDTAGHQQPFLELKIR---ANEP 228
Query: 296 GESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWDSWIIAPKEYEAYE 355
G AG R A C + V+F+++GW WI+ P+ Y+
Sbjct: 229 G-------------AGRARRRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNY 275
Query: 356 CKGGCFFPLADD--VTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYKDDMGVPT 413
C G C LA + + H+ V +L+ P +CCVPT P+S+LY D G
Sbjct: 276 CSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNG-NV 334
Query: 414 LKYHYEGMSVAECGC 428
+K M V CGC
Sbjct: 335 VKTDVPDMVVEACGC 349
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 71.6 bits (174), Expect = 1e-12
Identities = 90/387 (23%), Positives = 149/387 (38%), Gaps = 82/387 (21%)
Query: 59 LENVKVDFLRSLNLSGVPSQDKT-------RVEPPQYMIDLYNRYTSDKSTTPASNIVRS 111
+E +K+ L L L P+ K + P + +ID Y+ D S +
Sbjct: 53 IEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYH 112
Query: 112 FSMEDAISITATEDFPFQ----KHILLFNISIP-RHEQITRAELRLYVSCQNHVDPSHDL 166
+ E I++ DF Q F S ++ ++ +A+L +Y+ V+ +
Sbjct: 113 ATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYL---RPVETPTTV 169
Query: 167 KGSVV--IYDVLDGTDAWDSATETKTFLVSQDIQDEGWETLEVSSAVKRWVRSDSTKSKN 224
++ I + DGT T ++ + + W++++V + ++ W++ + ++
Sbjct: 170 FVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLK----QPES 221
Query: 225 KLEVTVESHRKGCDTLDISVP-PGSRNL-PFFVVFSNDHSSGTKETRLELREMISHEQES 282
L + +++ + L ++ P PG L PF V D
Sbjct: 222 NLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTP-------------------- 261
Query: 283 VLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAGSHCQKTSLRVNFEDIGWD 342
K+ +D + E S E S C + L V+FE GWD
Sbjct: 262 --KRSRRDFGLDCDEHSTE-----------------------SRCCRYPLTVDFEAFGWD 296
Query: 343 SWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPIS 402
WIIAPK Y+A C G C F T LVH P CC PTK+SPI+
Sbjct: 297 -WIIAPKRYKANYCSGECEFVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPIN 349
Query: 403 VLYKDDMGVPTLKY-HYEGMSVAECGC 428
+LY + G + Y M V CGC
Sbjct: 350 MLYFN--GKEQIIYGKIPAMVVDRCGC 374
>gi|153792495 growth differentiation factor 15 [Homo sapiens]
Length = 308
Score = 68.6 bits (166), Expect = 1e-11
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 13/142 (9%)
Query: 295 AGESSHEEDTDGHVAAGSTLARRKRSAGAGSHC--------QKTSLRVNFEDIGWDSWII 346
A SS + H+ + RR+ A G HC + ++R + ED+GW W++
Sbjct: 171 AESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVL 230
Query: 347 APKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYK 406
+P+E + C G C + HA ++T +H P V CCVP +P+ ++ K
Sbjct: 231 SPREVQVTMCIGAC---PSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQK 287
Query: 407 DDMGVPTLKYHYEGMSVAECGC 428
D GV Y+ + +C C
Sbjct: 288 TDTGVSL--QTYDDLLAKDCHC 307
>gi|239757187 PREDICTED: similar to growth differentiation factor 15
[Homo sapiens]
Length = 270
Score = 68.6 bits (166), Expect = 1e-11
Identities = 39/142 (27%), Positives = 64/142 (45%), Gaps = 13/142 (9%)
Query: 295 AGESSHEEDTDGHVAAGSTLARRKRSAGAGSHC--------QKTSLRVNFEDIGWDSWII 346
A SS + H+ + RR+ A G HC + ++R + ED+GW W++
Sbjct: 133 AESSSARPQLELHLRPQAARGRRRARARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVL 192
Query: 347 APKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISVLYK 406
+P+E + C G C + HA ++T +H P V CCVP +P+ ++ K
Sbjct: 193 SPREVQVTMCIGAC---PSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQK 249
Query: 407 DDMGVPTLKYHYEGMSVAECGC 428
D GV Y+ + +C C
Sbjct: 250 TDTGVSL--QTYDDLLAKDCHC 269
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 67.4 bits (163), Expect = 2e-11
Identities = 41/104 (39%), Positives = 50/104 (48%), Gaps = 8/104 (7%)
Query: 325 SHCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKF 384
S C + L V+FE GWD WIIAPK Y+A C G C + T LV
Sbjct: 311 SRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGQCEYMFMQKYPHTH------LVQQAN 363
Query: 385 PTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
P CC PTK+SPI++LY +D + GM V CGC
Sbjct: 364 PRGSAGPCCTPTKMSPINMLYFNDK-QQIIYGKIPGMVVDRCGC 406
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 64.7 bits (156), Expect = 2e-10
Identities = 48/144 (33%), Positives = 65/144 (45%), Gaps = 12/144 (8%)
Query: 294 EAGESSHEEDTDGHVAAGSTLAR-RKRSA---GAGSHCQKTSLRVNFEDIGWDSWIIAPK 349
+ GE SH G + R RKR G + C + ++F IGW+ WIIAP
Sbjct: 266 DPGEESHRPFVVVQARLGDSRHRIRKRGLECDGRTNLCCRQQFFIDFRLIGWNDWIIAPT 325
Query: 350 EYEAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTK-----VGKACCVPTKLSPISVL 404
Y C+G C LA P + T V ++ + +CC+PTKLS +S+L
Sbjct: 326 GYYGNYCEGSCPAYLAG--VPGSASSFHTAVVNQYRMRGLNPGTVNSCCIPTKLSTMSML 383
Query: 405 YKDDMGVPTLKYHYEGMSVAECGC 428
Y DD +K M V ECGC
Sbjct: 384 YFDD-EYNIVKRDVPNMIVEECGC 406
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 61.2 bits (147), Expect = 2e-09
Identities = 47/156 (30%), Positives = 65/156 (41%), Gaps = 10/156 (6%)
Query: 281 ESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSA---GAGSHCQKTSLRVNFE 337
E VL+ S G ++H V G +R G C + V+F
Sbjct: 198 ELVLEGQVAQSSVILGGAAHRPFVAARVRVGGKHQIHRRGIDCQGGSRMCCRQEFFVDFR 257
Query: 338 DIGWDSWIIAPKEYEAYECKGGCFFPLA--DDVTPTKHAIVQTLV--HLKFPTKVGKACC 393
+IGW WII P+ Y C G C +A + + H V L+ + T G +CC
Sbjct: 258 EIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKANTAAGTTGGGSCC 317
Query: 394 VPTKLSPISVLYKD-DMGVPTLKYHYEGMSVAECGC 428
VPT P+S+LY D D + +K M V CGC
Sbjct: 318 VPTARRPLSLLYYDRDSNI--VKTDIPDMVVEACGC 351
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 55.8 bits (133), Expect = 7e-08
Identities = 89/408 (21%), Positives = 160/408 (39%), Gaps = 69/408 (16%)
Query: 59 LENVKVDFLRSLNLSGVPSQDKTRVEPPQYMIDLYNR---YTSDKSTTPASNIVRSFSME 115
+E ++ L L L+ P E P +I +YN +K++ A+ R S E
Sbjct: 37 IEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDE 96
Query: 116 D-----AISITATEDFPFQK-----------HILLFNISIPRHE--QITRAELRLYVSCQ 157
+ I FP + I+ F++S + +AE R++ Q
Sbjct: 97 EYYAKEVYKIDMPPFFPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF-RLQ 155
Query: 158 NHVDPSHDLKGSVVIYDVLDGTDAWDSATETKTFLVSQDIQDEG---WETLEVSSAVKRW 214
N + + + +Y +L D + T+ ++ S+ ++ W + +V+ AV W
Sbjct: 156 N--PKARVPEQRIELYQILKSKDL---TSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEW 210
Query: 215 VRSDSTKSKNKLEVTVESHRKGCDTLDIS---VPPGSRNLPFF---VVFSNDHSSGTKET 268
+ K +N L + H C + + +P S L + ++ ++SG ++T
Sbjct: 211 LHH---KDRN-LGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKT 266
Query: 269 RLELREMISHEQESVLKKLSKDGSTEAGESSHEEDTDGHVAAGSTLARRKRSAGAG---- 324
R+ S + +L L E+ +++ R+KR+ A
Sbjct: 267 IKSTRKKNSGKTPHLLLMLLPSYRLESQQTNR---------------RKKRALDAAYCFR 311
Query: 325 ---SHCQKTSLRVNFE-DIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLV 380
+C L ++F+ D+GW WI PK Y A C G C + + D T+H+ V +L
Sbjct: 312 NVQDNCCLRPLYIDFKRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLY 367
Query: 381 HLKFPTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGC 428
+ P CCV L P+++LY +G M V C C
Sbjct: 368 NTINPEASASPCCVSQDLEPLTILYY--IGKTPKIEQLSNMIVKSCKC 413
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,615,393
Number of Sequences: 37866
Number of extensions: 819607
Number of successful extensions: 2480
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 32
Number of HSP's that attempted gapping in prelim test: 2350
Number of HSP's gapped (non-prelim): 98
length of query: 429
length of database: 18,247,518
effective HSP length: 105
effective length of query: 324
effective length of database: 14,271,588
effective search space: 4623994512
effective search space used: 4623994512
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.