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Search of human proteins with 140561070
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|140561070 RIM-binding protein 2 [Homo sapiens]
(1052 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|140561070 RIM-binding protein 2 [Homo sapiens] 2117 0.0
gi|171906567 peripheral benzodiazepine receptor-associated prote... 425 e-118
gi|171906559 peripheral benzodiazepine receptor-associated prote... 425 e-118
gi|191252806 RIMS binding protein 3C [Homo sapiens] 306 9e-83
gi|191252814 RIMS binding protein 3B [Homo sapiens] 304 3e-82
gi|153792195 DKFZP434H0735 protein [Homo sapiens] 212 2e-54
gi|11321634 CD2-associated protein [Homo sapiens] 63 2e-09
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 62 3e-09
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 61 6e-09
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 55 5e-07
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 55 5e-07
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 55 5e-07
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 55 5e-07
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 55 5e-07
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 54 6e-07
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 54 6e-07
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 54 8e-07
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 52 4e-06
gi|39930351 dynamin binding protein [Homo sapiens] 50 1e-05
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 50 1e-05
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 50 1e-05
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 50 1e-05
gi|109689723 abl interactor 2 [Homo sapiens] 49 2e-05
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 49 3e-05
gi|24308229 protein kinase C and casein kinase substrate in neur... 49 3e-05
gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens] 47 9e-05
gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens] 47 1e-04
gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens] 47 1e-04
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 47 1e-04
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 47 1e-04
>gi|140561070 RIM-binding protein 2 [Homo sapiens]
Length = 1052
Score = 2117 bits (5485), Expect = 0.0
Identities = 1052/1052 (100%), Positives = 1052/1052 (100%)
Query: 1 MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKSKVRELEEKCRTQSEQFNLLSRDLEK 60
MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKSKVRELEEKCRTQSEQFNLLSRDLEK
Sbjct: 1 MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKSKVRELEEKCRTQSEQFNLLSRDLEK 60
Query: 61 FRQHAGKIDLLGGSAVAPLDISTAPSKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRP 120
FRQHAGKIDLLGGSAVAPLDISTAPSKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRP
Sbjct: 61 FRQHAGKIDLLGGSAVAPLDISTAPSKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRP 120
Query: 121 LPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNP 180
LPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNP
Sbjct: 121 LPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNP 180
Query: 181 FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLA 240
FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLA
Sbjct: 181 FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLA 240
Query: 241 STLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYP 300
STLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYP
Sbjct: 241 STLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYP 300
Query: 301 RKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMA 360
RKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMA
Sbjct: 301 RKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMA 360
Query: 361 ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSH 420
ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSH
Sbjct: 361 ACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSH 420
Query: 421 VIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFS 480
VIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFS
Sbjct: 421 VIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFS 480
Query: 481 TLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVI 540
TLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVI
Sbjct: 481 TLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVI 540
Query: 541 FPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSK 600
FPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSK
Sbjct: 541 FPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPELLVPPTPHPRPAPQSK 600
Query: 601 PLASSGVPETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQ 660
PLASSGVPETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQ
Sbjct: 601 PLASSGVPETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPGRRSPSPSRILPQPQ 660
Query: 661 GTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGA 720
GTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGA
Sbjct: 661 GTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSSAGQYAASDEEDAYDSPDFKRRGA 720
Query: 721 SVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSG 780
SVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSG
Sbjct: 721 SVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSG 780
Query: 781 TSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEESE 840
TSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEESE
Sbjct: 781 TSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEESE 840
Query: 841 TDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC 900
TDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC
Sbjct: 841 TDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC 900
Query: 901 ARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRRMVAL 960
ARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRRMVAL
Sbjct: 901 ARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRRMVAL 960
Query: 961 YDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDD 1020
YDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDD
Sbjct: 961 YDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDD 1020
Query: 1021 VEVYLSDAPSHYSQDTPMRSKAKRKKSVHFTP 1052
VEVYLSDAPSHYSQDTPMRSKAKRKKSVHFTP
Sbjct: 1021 VEVYLSDAPSHYSQDTPMRSKAKRKKSVHFTP 1052
>gi|171906567 peripheral benzodiazepine receptor-associated protein 1
isoform b [Homo sapiens]
Length = 1797
Score = 425 bits (1093), Expect = e-118
Identities = 301/865 (34%), Positives = 438/865 (50%), Gaps = 116/865 (13%)
Query: 1 MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKS------------------------K 36
MRE A+RRQQL++EH+QA L KQ+E+ LQ++ +
Sbjct: 381 MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQAR 440
Query: 37 VRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGS---------------------- 74
VRELEE+CR+Q+EQF+LL+++L+ FR H G +DLL +
Sbjct: 441 VRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPC 500
Query: 75 -AVAPLDISTAP----------SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQ 123
P D+ P S+P P + G+ K ES +S+ E I P+
Sbjct: 501 RGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESL--SNSSHSESIHNSPK 558
Query: 124 PGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDG 183
PE +A S E+D + + R ++ + +ARYSYNPF+G
Sbjct: 559 SCPTPEVDTA---------SEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEG 609
Query: 184 PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNE------- 236
PNENPEAELPLTAG+Y+Y+YG+MDEDGF+EGEL+DG+RGLVPSNFV+ V D++
Sbjct: 610 PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPP 669
Query: 237 --SRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGE 294
+ L+ + G E + G G+ + P + D +L + + +GE
Sbjct: 670 ELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDEL--SLSPSPEGLGE 727
Query: 295 -DIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKAL 353
VPYPR++ ++KQLA SV++ WEP PP + +++ V+ E R L G+ KA+
Sbjct: 728 PPAVPYPRRLVVLKQLAHSVVLAWEP---PPEQVELHGFHICVNGELRQALGPGAPPKAV 784
Query: 354 IEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLP 413
+E L++ A ISVQ +TSRGSSD L+C L VG V PS LRV +T SA+++W+P
Sbjct: 785 LENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVP 844
Query: 414 TNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-PHQMPWQLPLEQREK 472
NSN +H I+LN EE + Y F +LRP Y+ +V A+ P Q PW+ E+ E+
Sbjct: 845 GNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQ 904
Query: 473 KEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAK 532
+ A ++F+TLPAGPP P DV ++ G +P + +SW P + G SNG VTGY +YA
Sbjct: 905 RAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYAD 964
Query: 533 GQRVAEVIFPTADSTAVELVRLRSLE-AKGVTVRTLSAQGESVDSAVAAVPPEL------ 585
GQ++ EV PTA S VEL +L+ L+ + V VRT+S GES DS A + P L
Sbjct: 965 GQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLP 1024
Query: 586 --LVPPTPHPRPAPQSKPLASS----GVPETKDEHLGPHARMDEAWEQSRAPG--PVHGH 637
+ P+PHP P ++ PLAS+ G P + +H P + +P G
Sbjct: 1025 ARVSCPSPHPSPEARA-PLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGS 1083
Query: 638 MLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSS 697
+PP + + + + T ++T+ + AA +A+ SS
Sbjct: 1084 HEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASS 1143
Query: 698 AGQYAASDEE------DAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGDEYHTESSRGS 751
+ Q A + + D R A +D +ELG H + R S
Sbjct: 1144 STQGARAQQAPNTEMCQGGDPGSGLRPRAEKED---TAELG-----VHLVNSLVDHGRNS 1195
Query: 752 DLSDIMEEDEEELYSEMQLEDGGRR 776
DLSDI EE+EEE E + E+ G R
Sbjct: 1196 DLSDIQEEEEEE--EEEEEEELGSR 1218
Score = 207 bits (526), Expect = 5e-53
Identities = 127/275 (46%), Positives = 157/275 (57%), Gaps = 47/275 (17%)
Query: 776 RRPSGTSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDF 835
R +G + L A D GRR P+ G + RP T + SP
Sbjct: 1505 RSATGRAKEPLSRATETGEARGQDGSGRRGPQ-KRGVRVLRPSTAELVP-----ARSP-- 1556
Query: 836 YEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFY 895
SET + LP RIFVALFDYDP++MSPNPDA EEELPF+EGQI+KV+GDKDADGFY
Sbjct: 1557 ---SET-LAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFY 1612
Query: 896 RGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVE----------------K 939
+GE R G IPCNMV+E+ D QLL++G+L + +E
Sbjct: 1613 QGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGP 1672
Query: 940 IERSRRSGRRHS-------------------VSTRRMVALYDYDPRESSPNVDVEAELTF 980
+ RRS + S + MVA +DY+P+ESSPN+DVEAEL F
Sbjct: 1673 PPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPF 1732
Query: 981 CTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
GD+ITVFG +D+DGFYYGELNGQ+GLVPSNFLE
Sbjct: 1733 RAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLE 1767
Score = 70.9 bits (172), Expect = 6e-12
Identities = 36/62 (58%), Positives = 45/62 (72%), Gaps = 2/62 (3%)
Query: 170 HLCVARYSYNPFDG-PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNF 228
H VA + YNP + PN + EAELP AG + V+G MD+DGFY GE L+GQRGLVPSNF
Sbjct: 1707 HSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGE-LNGQRGLVPSNF 1765
Query: 229 VD 230
++
Sbjct: 1766 LE 1767
Score = 69.3 bits (168), Expect = 2e-11
Identities = 36/75 (48%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 947 GRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQ 1005
G R + +A Y Y+P E PN + EAEL G+ I ++G +DEDGF+ GEL +G+
Sbjct: 588 GSRGGARIQVFLARYSYNPFEG-PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGR 646
Query: 1006 KGLVPSNFLEEVPDD 1020
+GLVPSNF+E V DD
Sbjct: 647 RGLVPSNFVERVSDD 661
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/67 (52%), Positives = 41/67 (61%), Gaps = 1/67 (1%)
Query: 955 RRMVALYDYDPRESSPNVDV-EAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF 1013
R VAL+DYDP SPN D E EL F G I+ VFG+ D DGFY GE G+ G +P N
Sbjct: 1568 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1627
Query: 1014 LEEVPDD 1020
+ EV D
Sbjct: 1628 VAEVAVD 1634
Score = 54.3 bits (129), Expect = 6e-07
Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 851 RIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC-ARLGLIPCN 909
++F+A + Y+P PN + E ELP G+ I +YG+ D DGF+ GE R GL+P N
Sbjct: 596 QVFLARYSYNPFE-GPNENP-EAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSN 653
Query: 910 MVSEIQADD 918
V + DD
Sbjct: 654 FVERVSDDD 662
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 169 VHLCVARYSYNPFD-GPNENP-EAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPS 226
V + VA + Y+P PN + E ELP G+ L V+GD D DGFY+GE G+ G +P
Sbjct: 1567 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPC 1625
Query: 227 NFV 229
N V
Sbjct: 1626 NMV 1628
>gi|171906559 peripheral benzodiazepine receptor-associated protein 1
isoform a [Homo sapiens]
Length = 1857
Score = 425 bits (1093), Expect = e-118
Identities = 301/865 (34%), Positives = 438/865 (50%), Gaps = 116/865 (13%)
Query: 1 MREAAERRQQLQLEHDQALAVLSAKQQEIDLLQKS------------------------K 36
MRE A+RRQQL++EH+QA L KQ+E+ LQ++ +
Sbjct: 441 MREVAQRRQQLEVEHEQARLSLREKQEEVRRLQQAQAEAQREHEGAVQLLESTLDSMQAR 500
Query: 37 VRELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGS---------------------- 74
VRELEE+CR+Q+EQF+LL+++L+ FR H G +DLL +
Sbjct: 501 VRELEEQCRSQTEQFSLLAQELQAFRLHPGPLDLLTSALDCGSLGDCPPPPCCCSIPQPC 560
Query: 75 -AVAPLDISTAP----------SKPFPQFMNGLATSLGKGQESAIGGSSAIGEYIRPLPQ 123
P D+ P S+P P + G+ K ES +S+ E I P+
Sbjct: 561 RGSGPKDLDLPPGSPGRCTPKSSEPAPATLTGVPRRTAKKAESL--SNSSHSESIHNSPK 618
Query: 124 PGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDG 183
PE +A S E+D + + R ++ + +ARYSYNPF+G
Sbjct: 619 SCPTPEVDTA---------SEVEELEADSVSLLPAAPEGSRGGARIQVFLARYSYNPFEG 669
Query: 184 PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNE------- 236
PNENPEAELPLTAG+Y+Y+YG+MDEDGF+EGEL+DG+RGLVPSNFV+ V D++
Sbjct: 670 PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSNFVERVSDDDLLTSLPP 729
Query: 237 --SRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSAGTLDVNIDDIGE 294
+ L+ + G E + G G+ + P + D +L + + +GE
Sbjct: 730 ELADLSHSSGPELSFLSVGGGGSSSGGQSSVGRSQPRPEEEDAGDEL--SLSPSPEGLGE 787
Query: 295 -DIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKAL 353
VPYPR++ ++KQLA SV++ WEP PP + +++ V+ E R L G+ KA+
Sbjct: 788 PPAVPYPRRLVVLKQLAHSVVLAWEP---PPEQVELHGFHICVNGELRQALGPGAPPKAV 844
Query: 354 IEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLP 413
+E L++ A ISVQ +TSRGSSD L+C L VG V PS LRV +T SA+++W+P
Sbjct: 845 LENLDLWAGPLHISVQALTSRGSSDPLRCCLAVGARAGVVPSQLRVHRLTATSAEITWVP 904
Query: 414 TNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-PHQMPWQLPLEQREK 472
NSN +H I+LN EE + Y F +LRP Y+ +V A+ P Q PW+ E+ E+
Sbjct: 905 GNSNLAHAIYLNGEECPPASPSTYWATFCHLRPGTPYQAQVEAQLPPQGPWEPGWERLEQ 964
Query: 473 KEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAK 532
+ A ++F+TLPAGPP P DV ++ G +P + +SW P + G SNG VTGY +YA
Sbjct: 965 RAATLQFTTLPAGPPDAPLDVQIEPGPSPGILIISWLPVTIDAAGTSNGVRVTGYAIYAD 1024
Query: 533 GQRVAEVIFPTADSTAVELVRLRSLE-AKGVTVRTLSAQGESVDSAVAAVPPEL------ 585
GQ++ EV PTA S VEL +L+ L+ + V VRT+S GES DS A + P L
Sbjct: 1025 GQKIMEVASPTAGSVLVELSQLQLLQVCREVVVRTMSPHGESADSIPAPITPALAPASLP 1084
Query: 586 --LVPPTPHPRPAPQSKPLASS----GVPETKDEHLGPHARMDEAWEQSRAPG--PVHGH 637
+ P+PHP P ++ PLAS+ G P + +H P + +P G
Sbjct: 1085 ARVSCPSPHPSPEARA-PLASASPGPGDPSSPLQHPAPLGTQEPPGAPPASPSREMAKGS 1143
Query: 638 MLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEKRSVFLERSS 697
+PP + + + + T ++T+ + AA +A+ SS
Sbjct: 1144 HEDPPAPCSQEEAGAAVLGTSEERTASTSTLGEKDPGPAAPSLAKQEAEWTAGEACPASS 1203
Query: 698 AGQYAASDEE------DAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGDEYHTESSRGS 751
+ Q A + + D R A +D +ELG H + R S
Sbjct: 1204 STQGARAQQAPNTEMCQGGDPGSGLRPRAEKED---TAELG-----VHLVNSLVDHGRNS 1255
Query: 752 DLSDIMEEDEEELYSEMQLEDGGRR 776
DLSDI EE+EEE E + E+ G R
Sbjct: 1256 DLSDIQEEEEEE--EEEEEEELGSR 1278
Score = 207 bits (526), Expect = 5e-53
Identities = 127/275 (46%), Positives = 157/275 (57%), Gaps = 47/275 (17%)
Query: 776 RRPSGTSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDF 835
R +G + L A D GRR P+ G + RP T + SP
Sbjct: 1565 RSATGRAKEPLSRATETGEARGQDGSGRRGPQ-KRGVRVLRPSTAELVP-----ARSP-- 1616
Query: 836 YEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFY 895
SET + LP RIFVALFDYDP++MSPNPDA EEELPF+EGQI+KV+GDKDADGFY
Sbjct: 1617 ---SET-LAYQHLPVRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFY 1672
Query: 896 RGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVE----------------K 939
+GE R G IPCNMV+E+ D QLL++G+L + +E
Sbjct: 1673 QGEGGGRTGYIPCNMVAEVAVDSPAGRQQLLQRGYLSPDILLEGSGNGPFVYSTAHTTGP 1732
Query: 940 IERSRRSGRRHS-------------------VSTRRMVALYDYDPRESSPNVDVEAELTF 980
+ RRS + S + MVA +DY+P+ESSPN+DVEAEL F
Sbjct: 1733 PPKPRRSKKAESEGPAQPCPGPPKLVPSADLKAPHSMVAAFDYNPQESSPNMDVEAELPF 1792
Query: 981 CTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
GD+ITVFG +D+DGFYYGELNGQ+GLVPSNFLE
Sbjct: 1793 RAGDVITVFGGMDDDGFYYGELNGQRGLVPSNFLE 1827
Score = 70.9 bits (172), Expect = 6e-12
Identities = 36/62 (58%), Positives = 45/62 (72%), Gaps = 2/62 (3%)
Query: 170 HLCVARYSYNPFDG-PNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNF 228
H VA + YNP + PN + EAELP AG + V+G MD+DGFY GE L+GQRGLVPSNF
Sbjct: 1767 HSMVAAFDYNPQESSPNMDVEAELPFRAGDVITVFGGMDDDGFYYGE-LNGQRGLVPSNF 1825
Query: 229 VD 230
++
Sbjct: 1826 LE 1827
Score = 69.3 bits (168), Expect = 2e-11
Identities = 36/75 (48%), Positives = 49/75 (65%), Gaps = 2/75 (2%)
Query: 947 GRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQ 1005
G R + +A Y Y+P E PN + EAEL G+ I ++G +DEDGF+ GEL +G+
Sbjct: 648 GSRGGARIQVFLARYSYNPFEG-PNENPEAELPLTAGEYIYIYGNMDEDGFFEGELMDGR 706
Query: 1006 KGLVPSNFLEEVPDD 1020
+GLVPSNF+E V DD
Sbjct: 707 RGLVPSNFVERVSDD 721
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/67 (52%), Positives = 41/67 (61%), Gaps = 1/67 (1%)
Query: 955 RRMVALYDYDPRESSPNVDV-EAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNF 1013
R VAL+DYDP SPN D E EL F G I+ VFG+ D DGFY GE G+ G +P N
Sbjct: 1628 RIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGEGGGRTGYIPCNM 1687
Query: 1014 LEEVPDD 1020
+ EV D
Sbjct: 1688 VAEVAVD 1694
Score = 54.3 bits (129), Expect = 6e-07
Identities = 28/69 (40%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 851 RIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETC-ARLGLIPCN 909
++F+A + Y+P PN + E ELP G+ I +YG+ D DGF+ GE R GL+P N
Sbjct: 656 QVFLARYSYNPFE-GPNENP-EAELPLTAGEYIYIYGNMDEDGFFEGELMDGRRGLVPSN 713
Query: 910 MVSEIQADD 918
V + DD
Sbjct: 714 FVERVSDDD 722
Score = 48.9 bits (115), Expect = 2e-05
Identities = 28/63 (44%), Positives = 37/63 (58%), Gaps = 3/63 (4%)
Query: 169 VHLCVARYSYNPFD-GPNENP-EAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPS 226
V + VA + Y+P PN + E ELP G+ L V+GD D DGFY+GE G+ G +P
Sbjct: 1627 VRIFVALFDYDPVSMSPNPDAGEEELPFREGQILKVFGDKDADGFYQGE-GGGRTGYIPC 1685
Query: 227 NFV 229
N V
Sbjct: 1686 NMV 1688
>gi|191252806 RIMS binding protein 3C [Homo sapiens]
Length = 1639
Score = 306 bits (783), Expect = 9e-83
Identities = 306/1092 (28%), Positives = 461/1092 (42%), Gaps = 206/1092 (18%)
Query: 6 ERRQQLQLEHDQALAVLSAKQQEIDLLQ------------KSKVRELEEK--------CR 45
+R+QQLQ + +AL L +EI LQ S++ E + K R
Sbjct: 669 DRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHAR 728
Query: 46 TQSEQFNLLSRDLEKFRQHAGKID--LLGGSAVAPLDISTAP-SKPFPQFMNGLATSLGK 102
+ + +RD+++ R+ + + LG SA P T P S+P + + + S +
Sbjct: 729 PEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788
Query: 103 GQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSK 162
G A SS + R D EP S L GSA +
Sbjct: 789 GSMWATVPSSPTLD--RDTASEVDDLEPDSVSLA-LEMGGSAAPAAP------------- 832
Query: 163 QRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRG 222
K+ + +A+Y+YNPF+GPN++PE ELPLTAG Y+Y++GDMDEDGFYEGEL DG+RG
Sbjct: 833 -----KLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRG 887
Query: 223 LVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSA 282
LVPSNFV E I D + P
Sbjct: 888 LVPSNFV--------------------------------EQIPDSYIP------------ 903
Query: 283 GTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM 342
G L D+G +P + L + S++ G +VD+
Sbjct: 904 GCLPAKSPDLGPSQLPAGQDEALEED---SLLSG--------------KAQGMVDRGLCQ 946
Query: 343 NLTLGSRTKALIEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVV-VAPSHLRVDN 401
+ +GS+T+ E L+ T + + S G L LL K V+ +AP L + N
Sbjct: 947 MVRVGSKTEVATEILDTK--TEACQLGLLQSMGKQG-LSRPLLGTKGVLRMAPMQLHLQN 1003
Query: 402 ITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQM 461
+T SA ++W+ ++ + HV++L++ E + A Y F L P Y+V+V + +
Sbjct: 1004 VTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVR---L 1060
Query: 462 PWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNG 521
PW L + V F TL AGPP PP DV V+ +P + VSW P + G SNG
Sbjct: 1061 PWDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNG 1120
Query: 522 ANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLR-SLEAKGVTVRTLSAQGESVDSAVAA 580
VTGY VYA G +V EV TA ST +E +L+ L + V+VRT+S GES+DS A
Sbjct: 1121 VQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQ 1180
Query: 581 VPPELLV-------PPTPHPRPAPQSKPLASSGVPETKDEHLGPHARMDEAWEQSRAPGP 633
+P + + PP + P + + P+ L P + P
Sbjct: 1181 IPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLS--LAPPSAKASPHNPGSCGEP 1238
Query: 634 ----VHGHMLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEKR 689
+ EPP R SP L P S ++A A L ++
Sbjct: 1239 QAKFLEAFFEEPP-----RRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQK 1293
Query: 690 SVFLERSSAGQYAASDEEDAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGD-------- 741
S R + ++E+ Y + A L+ +E G + C
Sbjct: 1294 SPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLR-TECGPRKEPCQEKAALERVLR 1352
Query: 742 -----------EYHTESSRGSDLSDIMEEDEEELYSEMQ----LEDGGRRRPSGTSHNAL 786
+ SD ++++E++E L +++ E+ P AL
Sbjct: 1353 QKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQAL 1412
Query: 787 KI-----LGNPASAGRVDHMGR--RFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEES 839
+ L P+SA + + PRG GPQ
Sbjct: 1413 GVKRGCQLHEPSSALCPAPSAKVIKMPRG--GPQ-------------------------- 1444
Query: 840 ETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGET 899
+ GA PAR+FVAL DY+PL MS N AAEEEL F++ Q+++V+G +D FY E
Sbjct: 1445 QLGTGANT-PARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSEC 1503
Query: 900 CARLGLIPCNMVSEIQADDEEMMDQLLR---QGFLPLNTPVEKIE-----------RSRR 945
++G IP +V+E++ E+ D+ R QG LP +E +
Sbjct: 1504 NRQVGNIPGRLVAEMEVGTEQ-TDRRWRSPAQGHLPSVAHLEDFQGLIIPQGSSLVLQGN 1562
Query: 946 SGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQ 1005
S R + + M+A DYDP + + L GD++ V+G +D+ GFYYGEL G
Sbjct: 1563 SKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGH 1622
Query: 1006 KGLVPSNFLEEV 1017
+GLVP++ L+ +
Sbjct: 1623 RGLVPAHLLDHM 1634
Score = 71.6 bits (174), Expect = 4e-12
Identities = 35/63 (55%), Positives = 47/63 (74%), Gaps = 2/63 (3%)
Query: 958 VALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQKGLVPSNFLEE 1016
+A Y+Y+P E PN E EL GD I +FG++DEDGFY GEL +G++GLVPSNF+E+
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQ 896
Query: 1017 VPD 1019
+PD
Sbjct: 897 IPD 899
>gi|191252814 RIMS binding protein 3B [Homo sapiens]
Length = 1639
Score = 304 bits (779), Expect = 3e-82
Identities = 305/1092 (27%), Positives = 461/1092 (42%), Gaps = 206/1092 (18%)
Query: 6 ERRQQLQLEHDQALAVLSAKQQEIDLLQ------------KSKVRELEEK--------CR 45
+R+QQLQ + +AL L +EI LQ S++ E + K R
Sbjct: 669 DRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHAR 728
Query: 46 TQSEQFNLLSRDLEKFRQHAGKID--LLGGSAVAPLDISTAP-SKPFPQFMNGLATSLGK 102
+ + +RD+++ R+ + + LG SA P T P S+P + + + S +
Sbjct: 729 PEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788
Query: 103 GQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSK 162
G A SS + R D EP S L GSA +
Sbjct: 789 GSMWATVPSSPTLD--RDTASEVDDLEPDSVSLA-LEMGGSAAPAAP------------- 832
Query: 163 QRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRG 222
K+ + +A+Y+YNPF+GPN++PE ELPLTAG Y+Y++GDMDEDGFYEGEL DG+RG
Sbjct: 833 -----KLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRG 887
Query: 223 LVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSA 282
LVPSNFV E I D + P
Sbjct: 888 LVPSNFV--------------------------------EQIPDSYIP------------ 903
Query: 283 GTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM 342
G L D+G +P + L + S++ G +VD+
Sbjct: 904 GCLPAKSPDLGPSQLPAGQDEALEED---SLLSG--------------KAQGMVDRGLCQ 946
Query: 343 NLTLGSRTKALIEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVV-VAPSHLRVDN 401
+ +GS+T+ E L+ T + + S G L LL K V+ +AP L + N
Sbjct: 947 MVRVGSKTEVATEILDTK--TEACQLGLLQSMGKQG-LSRPLLGTKGVLRMAPMQLHLQN 1003
Query: 402 ITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQM 461
+T SA ++W+ ++ + HV++L++ E + A Y F L P Y+V+V + +
Sbjct: 1004 VTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRVRVEVR---L 1060
Query: 462 PWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNG 521
PW L + V F TL AGPP PP +V V+ +P + VSW P + G SNG
Sbjct: 1061 PWDLLQVYWGTMSSTVTFDTLLAGPPYPPLEVLVERHASPGVLVVSWLPVTIDSAGSSNG 1120
Query: 522 ANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLR-SLEAKGVTVRTLSAQGESVDSAVAA 580
VTGY VYA G +V EV TA ST +E +L+ L + V+VRT+S GES+DS A
Sbjct: 1121 VQVTGYAVYADGLKVCEVADATAGSTVLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQ 1180
Query: 581 VPPELLV-------PPTPHPRPAPQSKPLASSGVPETKDEHLGPHARMDEAWEQSRAPGP 633
+P + + PP + P + + P+ L P + P
Sbjct: 1181 IPEDFFMCHRWPETPPFSYTCGDPSTYRVTFPVCPQKLS--LAPPSAKASPHNPGSCGEP 1238
Query: 634 ----VHGHMLEPPVGPGRRSPSPSRILPQPQGTPVSTTVAKAMAREAAQRVAESSRLEKR 689
+ EPP R SP L P S ++A A L ++
Sbjct: 1239 QAKFLEAFFEEPP-----RRQSPVSNLGSEGECPSSGAGSQAQELAEAWEGCRKDLLFQK 1293
Query: 690 SVFLERSSAGQYAASDEEDAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGD-------- 741
S R + ++E+ Y + A L+ +E G + C
Sbjct: 1294 SPQNHRPPSVSDQPGEKENCYQHMGTSKSPAPGFIHLR-TECGPRKEPCQEKAALERVLR 1352
Query: 742 -----------EYHTESSRGSDLSDIMEEDEEELYSEMQ----LEDGGRRRPSGTSHNAL 786
+ SD ++++E++E L +++ E+ P AL
Sbjct: 1353 QKQDAQGFTPPQLGASQQYASDFHNVLKEEQEALCLDLRGTERREERREPEPHSRQGQAL 1412
Query: 787 KI-----LGNPASAGRVDHMGR--RFPRGSAGPQRSRPVTVPSIDDYGRDRLSPDFYEES 839
+ L P+SA + + PRG GPQ
Sbjct: 1413 GVKRGCQLHEPSSALCPAPSAKVIKMPRG--GPQ-------------------------- 1444
Query: 840 ETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGET 899
+ GA PAR+FVAL DY+PL MS N AAEEEL F++ Q+++V+G +D FY E
Sbjct: 1445 QLGTGANT-PARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSEC 1503
Query: 900 CARLGLIPCNMVSEIQADDEEMMDQLLR---QGFLPLNTPVEKIE-----------RSRR 945
++G IP +V+E++ E+ D+ R QG LP +E +
Sbjct: 1504 NRQVGNIPGRLVAEMEVGTEQ-TDRRWRSPAQGHLPSVAHLEDFQGLTIPQGSSLVLQGN 1562
Query: 946 SGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQ 1005
S R + + M+A DYDP + + L GD++ V+G +D+ GFYYGEL G
Sbjct: 1563 SKRLPLWTPKIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGH 1622
Query: 1006 KGLVPSNFLEEV 1017
+GLVP++ L+ +
Sbjct: 1623 RGLVPAHLLDHM 1634
Score = 71.6 bits (174), Expect = 4e-12
Identities = 35/63 (55%), Positives = 47/63 (74%), Gaps = 2/63 (3%)
Query: 958 VALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQKGLVPSNFLEE 1016
+A Y+Y+P E PN E EL GD I +FG++DEDGFY GEL +G++GLVPSNF+E+
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELDDGRRGLVPSNFVEQ 896
Query: 1017 VPD 1019
+PD
Sbjct: 897 IPD 899
>gi|153792195 DKFZP434H0735 protein [Homo sapiens]
Length = 1639
Score = 212 bits (539), Expect = 2e-54
Identities = 190/615 (30%), Positives = 276/615 (44%), Gaps = 117/615 (19%)
Query: 6 ERRQQLQLEHDQALAVLSAKQQEIDLLQ------------KSKVRELEEK--------CR 45
+R+QQLQ + +AL L +EI LQ S++ E + K R
Sbjct: 669 DRQQQLQRDPQKALCDLHPSWKEIQALQCRPGHPPEQPWETSQMPESQVKGSRRPKFHAR 728
Query: 46 TQSEQFNLLSRDLEKFRQHAGKID--LLGGSAVAPLDISTAP-SKPFPQFMNGLATSLGK 102
+ + +RD+++ R+ + + LG SA P T P S+P + + + S +
Sbjct: 729 PEDYAVSQPNRDIQEKREASLEESPVALGESASVPQVSETVPASQPLSKKTSSQSNSSSE 788
Query: 103 GQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENERNSNTSK 162
G A SS + R D EP S L GSA +
Sbjct: 789 GSMWATVPSSPTLD--RDTASEVDDLEPDSVSLA-LEMGGSAAPAAP------------- 832
Query: 163 QRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRG 222
K+ + +A+Y+YNPF+GPN++PE ELPLTAG Y+Y++GDMDEDGFYEGEL DG+RG
Sbjct: 833 -----KLKIFMAQYNYNPFEGPNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRG 887
Query: 223 LVPSNFVDFVQDNESRLASTLGNEQDQNFINHSGIGLEGEHILDLHSPTHIDAGITDNSA 282
LVPSNFV E I D + P + A D
Sbjct: 888 LVPSNFV--------------------------------EQIPDSYIPGCLPAKSPDLGP 915
Query: 283 GTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM 342
L D+ E+ +L+ A+ V VD+
Sbjct: 916 SQLPAGQDEALEED-------SLLSGKAQGV----------------------VDRGLCQ 946
Query: 343 NLTLGSRTKALIEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVV-VAPSHLRVDN 401
+ +GS+T+ E L+ T + + S G L LL K V+ +AP L + N
Sbjct: 947 MVRVGSKTEVATEILDTK--TEACQLGLLQSMGKQG-LSRPLLGTKGVLRMAPMQLHLQN 1003
Query: 402 ITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQM 461
+T SA ++W+ ++ + HV++L++ E + A Y F L P Y+ +V + +
Sbjct: 1004 VTATSANITWVYSSHRHPHVVYLDDREHALTPAGVSCYTFQGLCPGTHYRARVEVR---L 1060
Query: 462 PWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNG 521
P L + V F TL AGPP PP DV V+ +P + VSW P + G SNG
Sbjct: 1061 PRDLLQVYWGTMSSTVTFDTLLAGPPYPPLDVLVERHASPGVLVVSWLPVTIDSAGSSNG 1120
Query: 522 ANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLR-SLEAKGVTVRTLSAQGESVDSAVAA 580
VTGY VYA G +V EV TA ST +E +L+ L + V+VRT+S GES+DS A
Sbjct: 1121 VQVTGYAVYADGLKVCEVADATAGSTLLEFSQLQVPLTWQKVSVRTMSLCGESLDSVPAQ 1180
Query: 581 VPPELLV----PPTP 591
+P + + P TP
Sbjct: 1181 IPEDFFMCHRWPETP 1195
Score = 116 bits (291), Expect = 1e-25
Identities = 68/183 (37%), Positives = 102/183 (55%), Gaps = 15/183 (8%)
Query: 849 PARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPC 908
PAR+FVAL DY+PL MS N AAEEEL F++ Q+++V+G +D FY E ++G IP
Sbjct: 1453 PARVFVALSDYNPLVMSANLKAAEEELVFQKRQLLRVWGSQDTHDFYLSECNRQVGNIPG 1512
Query: 909 NMVSEIQADDEEMMDQLLR---QGFLPLNTPVEKIE-----------RSRRSGRRHSVST 954
+V+E++ E+ D+ R QG LP +E + S R +
Sbjct: 1513 RLVAEMEVGTEQ-TDRRWRSPAQGNLPSVAHLEDFQGLTIPQGSSLVLQGNSKRLPLWTP 1571
Query: 955 RRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFL 1014
+ M+A DYDP + + L GD++ V+G +D+ GFYYGEL G +GLVP++ L
Sbjct: 1572 KIMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGELGGHRGLVPAHLL 1631
Query: 1015 EEV 1017
+ +
Sbjct: 1632 DHM 1634
Score = 71.6 bits (174), Expect = 4e-12
Identities = 35/63 (55%), Positives = 47/63 (74%), Gaps = 2/63 (3%)
Query: 958 VALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQKGLVPSNFLEE 1016
+A Y+Y+P E PN E EL GD I +FG++DEDGFY GEL +G++GLVPSNF+E+
Sbjct: 838 MAQYNYNPFEG-PNDHPEGELPLTAGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQ 896
Query: 1017 VPD 1019
+PD
Sbjct: 897 IPD 899
Score = 59.3 bits (142), Expect = 2e-08
Identities = 38/97 (39%), Positives = 50/97 (51%), Gaps = 5/97 (5%)
Query: 819 TVPSIDDYGRDRLSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFK 878
T +DD D +S P A +L +IF+A ++Y+P PN D E ELP
Sbjct: 805 TASEVDDLEPDSVSLALEMGGSAAPAAPKL--KIFMAQYNYNPFE-GPN-DHPEGELPLT 860
Query: 879 EGQIIKVYGDKDADGFYRGE-TCARLGLIPCNMVSEI 914
G I ++GD D DGFY GE R GL+P N V +I
Sbjct: 861 AGDYIYIFGDMDEDGFYEGELEDGRRGLVPSNFVEQI 897
Score = 49.7 bits (117), Expect = 1e-05
Identities = 27/61 (44%), Positives = 36/61 (59%), Gaps = 2/61 (3%)
Query: 171 LCVARYSYNPFDGP-NENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFV 229
+ +A Y+P DG + L L AG + VYG MD+ GFY GE L G RGLVP++ +
Sbjct: 1573 IMIAALDYDPGDGQMGGQGKGRLALRAGDVVMVYGPMDDQGFYYGE-LGGHRGLVPAHLL 1631
Query: 230 D 230
D
Sbjct: 1632 D 1632
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 62.8 bits (151), Expect = 2e-09
Identities = 53/187 (28%), Positives = 83/187 (44%), Gaps = 31/187 (16%)
Query: 853 FVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVS 912
++ +DYD + ++EL + G+II+ +G+ GE R G+ P N V
Sbjct: 4 YIVEYDYDAVH--------DDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVK 55
Query: 913 EIQADDEEMMDQL------------LRQGFLPLNTPVEKIE-RSRRSGRRHSVSTRRMVA 959
EI+ + E D L L Q P I+ + + R+
Sbjct: 56 EIKRETEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQCKV 115
Query: 960 LYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE--EV 1017
L++Y P+ E EL GDII + E+ E+G++ G LN + GL PSNF++ EV
Sbjct: 116 LFEYIPQN-------EDELELKVGDIIDINEEV-EEGWWSGTLNNKLGLFPSNFVKELEV 167
Query: 1018 PDDVEVY 1024
DD E +
Sbjct: 168 TDDGETH 174
Score = 40.0 bits (92), Expect = 0.012
Identities = 49/222 (22%), Positives = 79/222 (35%), Gaps = 69/222 (31%)
Query: 856 LFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVS--- 912
LF+Y P E+EL K G II + ++ +G++ G +LGL P N V
Sbjct: 116 LFEYIPQN--------EDELELKVGDIIDI-NEEVEEGWWSGTLNNKLGLFPSNFVKELE 166
Query: 913 --------EIQADDEEMM--------------------------------DQLLRQGFLP 932
E Q D E ++ + ++G +
Sbjct: 167 VTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVK 226
Query: 933 LNTPVEKIERSRRSGRRHSV----------------STRRMVALYDYDPRESSPNVDVEA 976
L T E + + + T + +Y + E
Sbjct: 227 LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNED 286
Query: 977 ELTFCTGDIITVFG-EIDEDGFYYGELNGQKGLVPSNFLEEV 1017
ELTF G+II + E E G++ GELNG++G+ P NF ++
Sbjct: 287 ELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI 328
Score = 35.4 bits (80), Expect = 0.28
Identities = 18/50 (36%), Positives = 30/50 (60%), Gaps = 1/50 (2%)
Query: 872 EEELPFKEGQIIKVYGDKDAD-GFYRGETCARLGLIPCNMVSEIQADDEE 920
E+EL FKEG+II + + + G++RGE + G+ P N +I D++
Sbjct: 285 EDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKD 334
Score = 33.1 bits (74), Expect = 1.4
Identities = 16/39 (41%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Query: 191 ELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFV 229
EL + G+ + + E+G+ EGEL +G+RG+ P NFV
Sbjct: 17 ELTIRVGEIIRNVKKLQEEGWLEGEL-NGRRGMFPDNFV 54
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 62.0 bits (149), Expect = 3e-09
Identities = 47/152 (30%), Positives = 74/152 (48%), Gaps = 17/152 (11%)
Query: 872 EEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQG-- 929
++EL G+II +D G++ G+ R GL P N V EI+ + ++ D L +
Sbjct: 15 DDELTISVGEIITNIRKEDG-GWWEGQINGRRGLFPDNFVREIKKEMKK--DPLTNKAPE 71
Query: 930 ----FLPLNTPVEKIERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDI 985
+P + E R+ +R RR + Y P+ EL GDI
Sbjct: 72 KPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDD-------ELELKVGDI 124
Query: 986 ITVFGEIDEDGFYYGELNGQKGLVPSNFLEEV 1017
I V GE++E G++ G LNG+ G+ PSNF++E+
Sbjct: 125 IEVVGEVEE-GWWEGVLNGKTGMFPSNFIKEL 155
Score = 42.7 bits (99), Expect = 0.002
Identities = 21/47 (44%), Positives = 32/47 (68%), Gaps = 1/47 (2%)
Query: 977 ELTFCTGDIITVFGEIDED-GFYYGELNGQKGLVPSNFLEEVPDDVE 1022
ELT GDI+T+ + D G++ GELNG++G+ P NF++ +P D E
Sbjct: 285 ELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
Score = 40.8 bits (94), Expect = 0.007
Identities = 35/128 (27%), Positives = 60/128 (46%), Gaps = 28/128 (21%)
Query: 134 KPTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELP 193
KP SG++ SE+ + + ++R C +SY P + + EL
Sbjct: 72 KPLHEVPSGNSLLSSETILRTNKRGERRRRR-------CQVAFSYLPQN------DDELE 118
Query: 194 LTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFV-------------QDNESRLA 240
L G + V G+++E G++EG +L+G+ G+ PSNF+ + Q ++S L
Sbjct: 119 LKVGDIIEVVGEVEE-GWWEG-VLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLR 176
Query: 241 STLGNEQD 248
T G+E D
Sbjct: 177 ETTGSESD 184
Score = 40.0 bits (92), Expect = 0.012
Identities = 17/46 (36%), Positives = 32/46 (69%), Gaps = 1/46 (2%)
Query: 977 ELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDVE 1022
ELT G+IIT + ++ G++ G++NG++GL P NF+ E+ +++
Sbjct: 17 ELTISVGEIITNIRK-EDGGWWEGQINGRRGLFPDNFVREIKKEMK 61
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 60.8 bits (146), Expect = 6e-09
Identities = 69/295 (23%), Positives = 120/295 (40%), Gaps = 28/295 (9%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNM 359
P+ + +I A + + W PP P G + +Y VL + + S T ++ L
Sbjct: 669 PQDVEVIDVTADEIRLKWSPPEKPN--GIIIAYEVLYKNIDTLYMKNTSTTDIILRNLR- 725
Query: 360 AACTYRISVQCVTSRGSSDELQCTLLVGKDVVV---APSHLRVDNITQISAQLSWLPTNS 416
Y ISV+ T G +++ L V V AP ++ NI+ +LS+LP +S
Sbjct: 726 PHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSS 785
Query: 417 N----YSHVIFL---NEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQ 469
+ I+L N E + L+ Y ++V A L+
Sbjct: 786 PNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSAS--------TLKG 837
Query: 470 REKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGV 529
+ A + T P +PPQD +V+ ++ T+++SW+PP L P G+ + Y V
Sbjct: 838 EGVRSAPISILTEEDAPDSPPQDFSVKQ-LSGVTVKLSWQPP-LEPNGI-----ILYYTV 890
Query: 530 YAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPE 584
Y + + I T S + + + VT T G++ + ++ PE
Sbjct: 891 YVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPE 945
Score = 48.5 bits (114), Expect = 3e-05
Identities = 54/218 (24%), Positives = 92/218 (42%), Gaps = 22/218 (10%)
Query: 311 KSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACT-YRISVQ 369
+SV+V W+PP G ++ Y V V++ N T S + + + A T Y V+
Sbjct: 1354 QSVLVKWDPPKKANG--IITQYMVTVER----NSTKVSPQDHMYTFIKLLANTSYVFKVR 1407
Query: 370 CVTSRGSSDELQCTLLVGKDVVVA-PSHLRVDNITQISAQLSWLPTNS------NYSHVI 422
TS G DE C + + V + P+++ ++ SA L+W+ ++ NY
Sbjct: 1408 ASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITT 1467
Query: 423 FLNEE---EFDIVKAARY-KYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQRE---KKEA 475
L + E++ + Y K Q+ V L K +Q+
Sbjct: 1468 QLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASN 1527
Query: 476 FVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVL 513
++ TLP P PP++V V A +P +I +SW P +
Sbjct: 1528 WISTKTLPGPPDGPPENVHVVA-TSPFSISISWSEPAV 1564
Score = 40.4 bits (93), Expect = 0.009
Identities = 63/310 (20%), Positives = 117/310 (37%), Gaps = 35/310 (11%)
Query: 297 VPYPRKITLIKQLAKS-VIVGWEPPAVPPGWGT-VSSYNVLVDKETRMNLT-------LG 347
VP KI K ++ S +++ W+PP P G T + Y + +D +T +
Sbjct: 568 VPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLIT 627
Query: 348 SRTKALIEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKD-VVVAPSHLRVDNITQIS 406
K K+ +AA T+ V S+E + +D +P + V ++T
Sbjct: 628 GLKKYTKYKMRVAASTH------VGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADE 681
Query: 407 AQLSWLPTNSNYS-----HVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQM 461
+L W P V++ N + + + NLRP+ Y + V +
Sbjct: 682 IRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTR-- 739
Query: 462 PWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNG 521
+ + + T P + P+++T + ++ I +S+ PP +P G+
Sbjct: 740 -----FGHGNQVSSLLSVRTSETVPDSAPENITYK-NISSGEIELSFLPP-SSPNGI--- 789
Query: 522 ANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAV 581
+ Y +Y K E S + L+ + V + +GE V SA ++
Sbjct: 790 --IQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
Query: 582 PPELLVPPTP 591
E P +P
Sbjct: 848 LTEEDAPDSP 857
Score = 38.5 bits (88), Expect = 0.034
Identities = 50/243 (20%), Positives = 91/243 (37%), Gaps = 32/243 (13%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLV-----DKETRMNLTLGSRTKALI 354
P IT + + + + PP+ P G + Y + + ++E +N T ++ ++
Sbjct: 763 PENITYKNISSGEIELSFLPPSSPNG--IIQKYTIYLKRSNGNEERTINTTSLTQNIKVL 820
Query: 355 EKLNMAACTYRISVQCVTSRGSS-DELQCTLLVGKDVVVAPSH-LRVDNITQISAQLSWL 412
+K Y I V T +G ++L +D +P V ++ ++ +LSW
Sbjct: 821 KKYTQ----YIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ 876
Query: 413 PTNSN-----YSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPL 467
P Y V N + + +L N+ Y V A
Sbjct: 877 PPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTR-------F 929
Query: 468 EQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGY 527
+ + + F T P PP+DV A ++ ++I + W PP P G+ + Y
Sbjct: 930 GDGKTRSNIISFQTPEGAPSDPPKDV-YYANLSSSSIILFWTPP-SKPNGI-----IQYY 982
Query: 528 GVY 530
VY
Sbjct: 983 SVY 985
Score = 35.8 bits (81), Expect = 0.22
Identities = 49/220 (22%), Positives = 83/220 (37%), Gaps = 20/220 (9%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNV---LVDKETRMNLTLGSRTKALIEK 356
P+ +TLI + V + W P +P G V S+ + D N++ G +T+A +
Sbjct: 1246 PQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNIS-GFKTEAKLVG 1304
Query: 357 LNMAACTYRISVQCVTSRGSSDELQ--CTLLVGKDVVVAPSHLRVDNITQISAQLSWLP- 413
L + TY I V T G+ ++ + V +++ + S + W P
Sbjct: 1305 LEPVS-TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPP 1363
Query: 414 --TNSNYSHVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQRE 471
N + + E V + Y F L N +Y KV A E
Sbjct: 1364 KKANGIITQYMVTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRAS---------TSAGE 1414
Query: 472 KKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPP 511
E+ STLP P+ P ++ + V + ++W P
Sbjct: 1415 GDESTCHVSTLPETVPSVPTNIAF-SDVQSTSATLTWIRP 1453
Score = 32.3 bits (72), Expect = 2.4
Identities = 44/206 (21%), Positives = 80/206 (38%), Gaps = 19/206 (9%)
Query: 262 EHILDLHSPTHIDAGITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAK-SVIVGWEPP 320
++IL + T + G +D L + + ED+ I K L+ SV++ W+PP
Sbjct: 1120 DYILKITPST--EKGFSDTYTAQLYIKTE---EDVPETSPIINTFKNLSSTSVLLSWDPP 1174
Query: 321 AVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRGSSDEL 380
P G + SY++ + + S ++E+L+ Y T +G
Sbjct: 1175 VKPN--GAIISYDLTLQGPNENYSFITSDNYIILEELS-PFTLYSFFAAARTRKGLGPSS 1231
Query: 381 QCTLLVGKDVVVA-PSHLRVDNITQISAQLSWLPTN------SNYSHVIFLNEEE---FD 430
+ V +A P +L + N T L W P+ YS I +E + +
Sbjct: 1232 ILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYK 1291
Query: 431 IVKAARYKYQFFNLRPNMAYKVKVLA 456
+ + + + L P Y ++V A
Sbjct: 1292 NISGFKTEAKLVGLEPVSTYSIRVSA 1317
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 54.7 bits (130), Expect = 5e-07
Identities = 68/246 (27%), Positives = 96/246 (39%), Gaps = 35/246 (14%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNM 359
PR + A ++IV WE P P G + Y V E +G+ K ++ +
Sbjct: 417 PRNVQARMLSATTMIVQWEEPVEPN--GLIRGYRVYYTMEPEH--PVGNWQKHNVDDSLL 472
Query: 360 AAC-------TYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQL 409
TY + V TS G SD +Q G V P +LR + ++ S L
Sbjct: 473 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG--VPGQPMNLRAEARSETSITL 530
Query: 410 SWLP--TNSNYSHVIFLNEEEFDIVKAARY----KYQFFNLRPNMAYKVKVLAKPHQMPW 463
SW P S + + E + + Y +L+PN Y ++ A+ Q
Sbjct: 531 SWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG 590
Query: 464 QLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGAN 523
R++ TL + P APPQDV V I VSWRPP P NGA
Sbjct: 591 AFTPVVRQR--------TLQSKPSAPPQDVKC-VSVRSTAILVSWRPP---PPETHNGA- 637
Query: 524 VTGYGV 529
+ GY V
Sbjct: 638 LVGYSV 643
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 54.7 bits (130), Expect = 5e-07
Identities = 68/246 (27%), Positives = 96/246 (39%), Gaps = 35/246 (14%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNM 359
PR + A ++IV WE P P G + Y V E +G+ K ++ +
Sbjct: 430 PRNVQARMLSATTMIVQWEEPVEPN--GLIRGYRVYYTMEPEH--PVGNWQKHNVDDSLL 485
Query: 360 AAC-------TYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQL 409
TY + V TS G SD +Q G V P +LR + ++ S L
Sbjct: 486 TTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQG--VPGQPMNLRAEARSETSITL 543
Query: 410 SWLP--TNSNYSHVIFLNEEEFDIVKAARY----KYQFFNLRPNMAYKVKVLAKPHQMPW 463
SW P S + + E + + Y +L+PN Y ++ A+ Q
Sbjct: 544 SWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLG 603
Query: 464 QLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGAN 523
R++ TL + P APPQDV V I VSWRPP P NGA
Sbjct: 604 AFTPVVRQR--------TLQSKPSAPPQDVKC-VSVRSTAILVSWRPP---PPETHNGA- 650
Query: 524 VTGYGV 529
+ GY V
Sbjct: 651 LVGYSV 656
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 54.7 bits (130), Expect = 5e-07
Identities = 69/307 (22%), Positives = 118/307 (38%), Gaps = 28/307 (9%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLN- 358
PR + + +++V W+ P P G + Y V + ++ + ++
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNG--QIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 359 ----MAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
+ TY + V TS G S ++Q G V P + + + ++ S LSW
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG--VPGQPLNFKAEPESETSILLSW 536
Query: 412 LPTNS----NYSHVIFLNE--EEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQL 465
P S NY V E EE I Y+ L+PN Y ++ A+ Q
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ----- 591
Query: 466 PLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWR-PPVLTPTGLSNGANV 524
A + T+ + P APPQD++ + +I VSW+ PPV G+ ++
Sbjct: 592 ---GLGASTAEISARTMQSKPSAPPQDISC-TSPSSTSILVSWQPPPVEKQNGIITEYSI 647
Query: 525 TGYGVYAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPE 584
V + + E++ +D+T L +L +TV + G +S +
Sbjct: 648 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 585 LLVPPTP 591
VP P
Sbjct: 708 EDVPSGP 714
Score = 34.3 bits (77), Expect = 0.63
Identities = 88/403 (21%), Positives = 148/403 (36%), Gaps = 89/403 (22%)
Query: 283 GTLDVNIDDIGEDIVP-YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVD---- 337
G L +I I + VP P + S+++ W PP T+++Y ++
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSD----TIANYELVYKDGEH 556
Query: 338 -KETRMNLTLGSRTKALIEKLN--------------MAACTYRISVQCVTSRGSS--DEL 380
+E R+ + G+ + K N + A T IS + + S+ S+ ++
Sbjct: 557 GEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616
Query: 381 QCTLLVGKDVVVA--PSHLRVDN--ITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAAR 436
CT ++V+ P + N IT+ S + + + + H I + +
Sbjct: 617 SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILG-------IPSDT 669
Query: 437 YKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQ 496
KY L Y++ V A P L V T P PP+ V V+
Sbjct: 670 TKYLLEQLEKWTEYRITVTAHTDVGPGPESLS--------VLIRTNEDVPSGPPRKVEVE 721
Query: 497 AGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLRS 556
A V +++VSWR PV + GY V+ VR+ +
Sbjct: 722 A-VNSTSVKVSWRSPVPN----KQHGQIRGYQVH--------------------YVRMEN 756
Query: 557 LEAKG----VTVRTLSAQGESVDSA-----VAAVPPE----LLVPPTPHPRPAPQSKP-- 601
E KG V AQ E D+ ++ + PE L V +SKP
Sbjct: 757 GEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 816
Query: 602 LASSGVPETKDEHLGPHARMDEAWEQSRAP----GPVHGHMLE 640
++++G K + H +M+ A Q P GP+ G+ L+
Sbjct: 817 VSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLK 859
Score = 30.8 bits (68), Expect = 7.0
Identities = 48/242 (19%), Positives = 93/242 (38%), Gaps = 29/242 (11%)
Query: 299 YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVL-----VDKETRMNLTLGSRTKAL 353
+P+ + + SV + W+PP + G ++ Y +L + L + + T
Sbjct: 921 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 980
Query: 354 IEKLNMAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLS 410
+ L TY + V+ TS+G S +Q L V H++ + + S LS
Sbjct: 981 LTGLK-PDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKA--VMKTSVLLS 1037
Query: 411 W-LPTNSNYS---HVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-------PH 459
W +P N N + +++ + + + V + NL+P +Y + + H
Sbjct: 1038 WEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQH 1097
Query: 460 QMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLS 519
++ + + K AF+ + L +TVQ PA + ++ P S
Sbjct: 1098 RVTAKTAPDVLRTKPAFIGKTNLDG-------MITVQLPEVPANENIKGYYIIIVPLKKS 1150
Query: 520 NG 521
G
Sbjct: 1151 RG 1152
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 54.7 bits (130), Expect = 5e-07
Identities = 69/307 (22%), Positives = 118/307 (38%), Gaps = 28/307 (9%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLN- 358
PR + + +++V W+ P P G + Y V + ++ + ++
Sbjct: 408 PRDVQARMLSSTTILVQWKEPEEPNG--QIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 465
Query: 359 ----MAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
+ TY + V TS G S ++Q G V P + + + ++ S LSW
Sbjct: 466 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG--VPGQPLNFKAEPESETSILLSW 523
Query: 412 LPTNS----NYSHVIFLNE--EEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQL 465
P S NY V E EE I Y+ L+PN Y ++ A+ Q
Sbjct: 524 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ----- 578
Query: 466 PLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWR-PPVLTPTGLSNGANV 524
A + T+ + P APPQD++ + +I VSW+ PPV G+ ++
Sbjct: 579 ---GLGASTAEISARTMQSKPSAPPQDISC-TSPSSTSILVSWQPPPVEKQNGIITEYSI 634
Query: 525 TGYGVYAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPE 584
V + + E++ +D+T L +L +TV + G +S +
Sbjct: 635 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 694
Query: 585 LLVPPTP 591
VP P
Sbjct: 695 EDVPSGP 701
Score = 34.3 bits (77), Expect = 0.63
Identities = 88/403 (21%), Positives = 148/403 (36%), Gaps = 89/403 (22%)
Query: 283 GTLDVNIDDIGEDIVP-YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVD---- 337
G L +I I + VP P + S+++ W PP T+++Y ++
Sbjct: 488 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSD----TIANYELVYKDGEH 543
Query: 338 -KETRMNLTLGSRTKALIEKLN--------------MAACTYRISVQCVTSRGSS--DEL 380
+E R+ + G+ + K N + A T IS + + S+ S+ ++
Sbjct: 544 GEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 603
Query: 381 QCTLLVGKDVVVA--PSHLRVDN--ITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAAR 436
CT ++V+ P + N IT+ S + + + + H I + +
Sbjct: 604 SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILG-------IPSDT 656
Query: 437 YKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQ 496
KY L Y++ V A P L V T P PP+ V V+
Sbjct: 657 TKYLLEQLEKWTEYRITVTAHTDVGPGPESLS--------VLIRTNEDVPSGPPRKVEVE 708
Query: 497 AGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLRS 556
A V +++VSWR PV + GY V+ VR+ +
Sbjct: 709 A-VNSTSVKVSWRSPVPN----KQHGQIRGYQVH--------------------YVRMEN 743
Query: 557 LEAKG----VTVRTLSAQGESVDSA-----VAAVPPE----LLVPPTPHPRPAPQSKP-- 601
E KG V AQ E D+ ++ + PE L V +SKP
Sbjct: 744 GEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKL 803
Query: 602 LASSGVPETKDEHLGPHARMDEAWEQSRAP----GPVHGHMLE 640
++++G K + H +M+ A Q P GP+ G+ L+
Sbjct: 804 VSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLK 846
Score = 30.8 bits (68), Expect = 7.0
Identities = 48/242 (19%), Positives = 93/242 (38%), Gaps = 29/242 (11%)
Query: 299 YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVL-----VDKETRMNLTLGSRTKAL 353
+P+ + + SV + W+PP + G ++ Y +L + L + + T
Sbjct: 908 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 967
Query: 354 IEKLNMAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLS 410
+ L TY + V+ TS+G S +Q L V H++ + + S LS
Sbjct: 968 LTGLK-PDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKA--VMKTSVLLS 1024
Query: 411 W-LPTNSNYS---HVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-------PH 459
W +P N N + +++ + + + V + NL+P +Y + + H
Sbjct: 1025 WEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQH 1084
Query: 460 QMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLS 519
++ + + K AF+ + L +TVQ PA + ++ P S
Sbjct: 1085 RVTAKTAPDVLRTKPAFIGKTNLDG-------MITVQLPEVPANENIKGYYIIIVPLKKS 1137
Query: 520 NG 521
G
Sbjct: 1138 RG 1139
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
3 precursor [Homo sapiens]
Length = 1903
Score = 54.7 bits (130), Expect = 5e-07
Identities = 69/307 (22%), Positives = 118/307 (38%), Gaps = 28/307 (9%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLN- 358
PR + + +++V W+ P P G + Y V + ++ + ++
Sbjct: 421 PRDVQARMLSSTTILVQWKEPEEPNG--QIQGYRVYYTMDPTQHVNNWMKHNVADSQITT 478
Query: 359 ----MAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
+ TY + V TS G S ++Q G V P + + + ++ S LSW
Sbjct: 479 IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTG--VPGQPLNFKAEPESETSILLSW 536
Query: 412 LPTNS----NYSHVIFLNE--EEFDIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQL 465
P S NY V E EE I Y+ L+PN Y ++ A+ Q
Sbjct: 537 TPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQ----- 591
Query: 466 PLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWR-PPVLTPTGLSNGANV 524
A + T+ + P APPQD++ + +I VSW+ PPV G+ ++
Sbjct: 592 ---GLGASTAEISARTMQSKPSAPPQDISC-TSPSSTSILVSWQPPPVEKQNGIITEYSI 647
Query: 525 TGYGVYAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDSAVAAVPPE 584
V + + E++ +D+T L +L +TV + G +S +
Sbjct: 648 KYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTN 707
Query: 585 LLVPPTP 591
VP P
Sbjct: 708 EDVPSGP 714
Score = 38.1 bits (87), Expect = 0.044
Identities = 84/394 (21%), Positives = 146/394 (37%), Gaps = 80/394 (20%)
Query: 283 GTLDVNIDDIGEDIVP-YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVD---- 337
G L +I I + VP P + S+++ W PP T+++Y ++
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSD----TIANYELVYKDGEH 556
Query: 338 -KETRMNLTLGSRTKALIEKLN--------------MAACTYRISVQCVTSRGSS--DEL 380
+E R+ + G+ + K N + A T IS + + S+ S+ ++
Sbjct: 557 GEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDI 616
Query: 381 QCTLLVGKDVVVA--PSHLRVDN--ITQISAQLSWLPTNSNYSHVIFLNEEEFDIVKAAR 436
CT ++V+ P + N IT+ S + + + + H I + +
Sbjct: 617 SCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILG-------IPSDT 669
Query: 437 YKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQ 496
KY L Y++ V A P L V T P PP+ V V+
Sbjct: 670 TKYLLEQLEKWTEYRITVTAHTDVGPGPESLS--------VLIRTNEDVPSGPPRKVEVE 721
Query: 497 AGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAVELVRLRS 556
A V +++VSWR PV + GY V+ VR+ +
Sbjct: 722 A-VNSTSVKVSWRSPVPN----KQHGQIRGYQVH--------------------YVRMEN 756
Query: 557 LEAKGVTVRTLSAQGESVDSAVAAVPPE----LLVPPTPHPRPAPQSKP--LASSGVPET 610
E KG + ++ D ++ + PE L V +SKP ++++G
Sbjct: 757 GEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG 816
Query: 611 KDEHLGPHARMDEAWEQSRAP----GPVHGHMLE 640
K + H +M+ A Q P GP+ G+ L+
Sbjct: 817 KPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLK 850
Score = 30.8 bits (68), Expect = 7.0
Identities = 48/242 (19%), Positives = 93/242 (38%), Gaps = 29/242 (11%)
Query: 299 YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVL-----VDKETRMNLTLGSRTKAL 353
+P+ + + SV + W+PP + G ++ Y +L + L + + T
Sbjct: 912 FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMT 971
Query: 354 IEKLNMAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLS 410
+ L TY + V+ TS+G S +Q L V H++ + + S LS
Sbjct: 972 LTGLK-PDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKA--VMKTSVLLS 1028
Query: 411 W-LPTNSNYS---HVIFLNEEEFDIVKAARYKYQFFNLRPNMAYKVKVLAK-------PH 459
W +P N N + +++ + + + V + NL+P +Y + + H
Sbjct: 1029 WEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQH 1088
Query: 460 QMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLS 519
++ + + K AF+ + L +TVQ PA + ++ P S
Sbjct: 1089 RVTAKTAPDVLRTKPAFIGKTNLDG-------MITVQLPEVPANENIKGYYIIIVPLKKS 1141
Query: 520 NG 521
G
Sbjct: 1142 RG 1143
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 54.3 bits (129), Expect = 6e-07
Identities = 91/331 (27%), Positives = 135/331 (40%), Gaps = 45/331 (13%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM--NLTLGSRTKA-LIEK 356
PR++ A +++V WEPP P G V Y V ++R N T A L+
Sbjct: 417 PRRVQARMLSASTMLVQWEPPEEPN--GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTT 474
Query: 357 LN--MAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
+ + TY + V T+ G S +Q G A V++ T+I QLSW
Sbjct: 475 VGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRI--QLSW 532
Query: 412 -LPTNSN---YSHVIFLNEEEFDIVKAA---RYKYQFFNLRPNMAYKVKVLAKPHQMPWQ 464
LP Y V + E+E K Y +L+P+ Y+ ++ A+
Sbjct: 533 LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGV 592
Query: 465 LPLEQREKKEAFVEFSTLPAGPPAPPQDV-TVQAGVTPATIRVSWRPPVLTPTGLSNGAN 523
+E T + P APPQ V V G T T+RVSW PP P NG
Sbjct: 593 F--------TPTIEARTAQSTPSAPPQKVMCVSMGST--TVRVSWVPP---PADSRNGV- 638
Query: 524 VTGYGV-------YAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDS 576
+T Y V +G+ V + I + + ++ +LV L V VR + G +S
Sbjct: 639 ITQYSVAYEAVDGEDRGRHVVDGI--SREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES 696
Query: 577 AVAAVPPELLVPPTPHPRPAPQSKPLASSGV 607
+ V + VP P PR + +PL S+ V
Sbjct: 697 SPVLVRTDEDVPSGP-PRKV-EVEPLNSTAV 725
Score = 32.3 bits (72), Expect = 2.4
Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%)
Query: 299 YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLV----DKETRMNLTLGSRTKALI 354
+P+ + + + + W+PP + G + SY V+ ++ N+T +R
Sbjct: 918 FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTG 977
Query: 355 EKLNMAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
K + TY I V+ TS+GS S +Q + + V + RV + S LSW
Sbjct: 978 LKPD---TTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA--KNFRVAAAMKTSVLLSW 1032
Query: 412 LPTNSNYSHV---IFLNEEEFDIVKAARYKYQFFNLRPNMAY 450
+S S V I N + ++ + K +L+PN Y
Sbjct: 1033 EVPDSYKSAVPFKILYNGQSVEVDGHSMRKL-IADLQPNTEY 1073
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 54.3 bits (129), Expect = 6e-07
Identities = 91/331 (27%), Positives = 135/331 (40%), Gaps = 45/331 (13%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRM--NLTLGSRTKA-LIEK 356
PR++ A +++V WEPP P G V Y V ++R N T A L+
Sbjct: 417 PRRVQARMLSASTMLVQWEPPEEPN--GLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTT 474
Query: 357 LN--MAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
+ + TY + V T+ G S +Q G A V++ T+I QLSW
Sbjct: 475 VGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRI--QLSW 532
Query: 412 -LPTNSN---YSHVIFLNEEEFDIVKAA---RYKYQFFNLRPNMAYKVKVLAKPHQMPWQ 464
LP Y V + E+E K Y +L+P+ Y+ ++ A+
Sbjct: 533 LLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGV 592
Query: 465 LPLEQREKKEAFVEFSTLPAGPPAPPQDV-TVQAGVTPATIRVSWRPPVLTPTGLSNGAN 523
+E T + P APPQ V V G T T+RVSW PP P NG
Sbjct: 593 F--------TPTIEARTAQSTPSAPPQKVMCVSMGST--TVRVSWVPP---PADSRNGV- 638
Query: 524 VTGYGV-------YAKGQRVAEVIFPTADSTAVELVRLRSLEAKGVTVRTLSAQGESVDS 576
+T Y V +G+ V + I + + ++ +LV L V VR + G +S
Sbjct: 639 ITQYSVAYEAVDGEDRGRHVVDGI--SREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPES 696
Query: 577 AVAAVPPELLVPPTPHPRPAPQSKPLASSGV 607
+ V + VP P PR + +PL S+ V
Sbjct: 697 SPVLVRTDEDVPSGP-PRKV-EVEPLNSTAV 725
Score = 32.3 bits (72), Expect = 2.4
Identities = 39/162 (24%), Positives = 68/162 (41%), Gaps = 16/162 (9%)
Query: 299 YPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLV----DKETRMNLTLGSRTKALI 354
+P+ + + + + W+PP + G + SY V+ ++ N+T +R
Sbjct: 909 FPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTG 968
Query: 355 EKLNMAACTYRISVQCVTSRGS---SDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSW 411
K + TY I V+ TS+GS S +Q + + V + RV + S LSW
Sbjct: 969 LKPD---TTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA--KNFRVAAAMKTSVLLSW 1023
Query: 412 LPTNSNYSHV---IFLNEEEFDIVKAARYKYQFFNLRPNMAY 450
+S S V I N + ++ + K +L+PN Y
Sbjct: 1024 EVPDSYKSAVPFKILYNGQSVEVDGHSMRKL-IADLQPNTEY 1064
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 53.9 bits (128), Expect = 8e-07
Identities = 52/174 (29%), Positives = 74/174 (42%), Gaps = 26/174 (14%)
Query: 872 EEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFL 931
E+EL G +++ A G+ RGE R GL P +V EI + LR G
Sbjct: 14 EDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIP--------ETLR-GSG 64
Query: 932 PLNTPVEKIERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGE 991
P + R R +H R + Y P ++ EL G+I+ + E
Sbjct: 65 EARRP--RCARRRGHPAKHPRPQRWCKVNFSYSPEQAD-------ELKLQAGEIVEMIKE 115
Query: 992 IDEDGFYYGELNGQKGLVPSNFLEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRK 1045
I EDG++ G+ NGQ G PSNF VE+ S PS + D P S ++
Sbjct: 116 I-EDGWWLGKKNGQLGAFPSNF-------VELLDSGPPSLGNPDMPSVSPGPQR 161
Score = 33.1 bits (74), Expect = 1.4
Identities = 30/107 (28%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 135 PTFLSRSGSARCRSESDMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPL 194
P L SG AR + + QR+ C +SY+P EL L
Sbjct: 57 PETLRGSGEARRPRCARRRGHPAKHPRPQRW------CKVNFSYSPEQAD------ELKL 104
Query: 195 TAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQDNESRLAS 241
AG+ + + ++ EDG++ G+ +GQ G PSNFV+ + L +
Sbjct: 105 QAGEIVEMIKEI-EDGWWLGKK-NGQLGAFPSNFVELLDSGPPSLGN 149
Score = 32.0 bits (71), Expect = 3.1
Identities = 22/50 (44%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 181 FDGPNENPEAELPLTAGKYLYVYGDMDED-GFYEGELLDGQRGLVPSNFV 229
FD E P+ EL L G + V ED G++EGE G+RG+ P NFV
Sbjct: 190 FDYQPEAPD-ELALRRGDVVKVLSKTTEDKGWWEGEC-QGRRGVFPDNFV 237
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 51.6 bits (122), Expect = 4e-06
Identities = 48/173 (27%), Positives = 76/173 (43%), Gaps = 31/173 (17%)
Query: 871 AEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMV--SEIQADDEEMMDQLLRQ 928
A++EL FK G I+KV ++ +Y+ E + G IP N + ++ ++LR
Sbjct: 13 ADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPFGNDVQHFKVLRD 72
Query: 929 G----------FLPLNTPVEKIERSRRSGRRHSVSTR----------RMVALYDYDPRES 968
G F LN V+ RS R + R + AL+D+DP+E
Sbjct: 73 GAGKYFLWVVKFNSLNELVD-YHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQE- 130
Query: 969 SPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDV 1021
+ EL F GD I V D + ++ G +GQ G+ P N++ V +V
Sbjct: 131 ------DGELGFRRGDFIHVMDNSDPN-WWKGACHGQTGMFPRNYVTPVNRNV 176
Score = 42.4 bits (98), Expect = 0.002
Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 7/61 (11%)
Query: 958 VALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEV 1017
+A YD+ + EL+F GDI+ V E + +Y ELNG+ G +P N++E
Sbjct: 4 IAKYDF-------KATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMK 56
Query: 1018 P 1018
P
Sbjct: 57 P 57
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 50.1 bits (118), Expect = 1e-05
Identities = 46/155 (29%), Positives = 72/155 (46%), Gaps = 20/155 (12%)
Query: 872 EEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIP---CNMVSEIQADDEEM----MDQ 924
+EEL F+EG +I + G + G++ GE R G+ P ++ ++ DE + D
Sbjct: 161 DEELDFREGDVITIIGVPEP-GWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDD 219
Query: 925 LLRQGFLPLNTPVEKIERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGD 984
+ G ++TPV + E + VALY + E PN EL F GD
Sbjct: 220 CIVNG--EVDTPVGEEEIGPDEDEEEPGTYG--VALYRFQALE--PN-----ELDFEVGD 268
Query: 985 IITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPD 1019
I + + EDG+ G L G+ G+ P F++ PD
Sbjct: 269 KIRILATL-EDGWLEGSLKGRTGIFPYRFVKLCPD 302
Score = 45.4 bits (106), Expect = 3e-04
Identities = 28/90 (31%), Positives = 49/90 (54%), Gaps = 4/90 (4%)
Query: 928 QGFLPLNTPVEKIERSRRSGRRHSVSTRRMVALYDYDPRES--SPNVDVEAELTFCTGDI 985
+GF P ++ V ++ S +S + HS S + Y + + ++ EL F GD+
Sbjct: 113 RGFFP-SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDV 171
Query: 986 ITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
IT+ G + E G++ GEL G++G+ P F+E
Sbjct: 172 ITIIG-VPEPGWFEGELEGRRGIFPEGFVE 200
Score = 35.4 bits (80), Expect = 0.28
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 5/99 (5%)
Query: 158 SNTSKQRYSGKVHLCVARYSYNP---FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEG 214
S+ S+Q +S + YS G + + EL G + + G + E G++EG
Sbjct: 127 SSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIG-VPEPGWFEG 185
Query: 215 ELLDGQRGLVPSNFVDFVQDNESRLASTLGNEQDQNFIN 253
EL +G+RG+ P FV+ + + S QD +N
Sbjct: 186 EL-EGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVN 223
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/222 (23%), Positives = 91/222 (40%), Gaps = 45/222 (20%)
Query: 820 VPSIDDYGRDRLSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKE 879
+ +D++ R R + + + D GA V L D+ P ++L
Sbjct: 413 ITPLDEHLRSRPNDPSHAQKPVDSGAPHA-----VVLHDF--------PAEQVDDLNLTS 459
Query: 880 GQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEK 939
G+I+ + D D +YRG ++G+ P N V I ++ P E
Sbjct: 460 GEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------------------IDIP-EG 499
Query: 940 IERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYY 999
R H V R VA ++Y + EL+F G+II + ++E+ +
Sbjct: 500 GNGKRECVSSHCVKGSRCVARFEYIGEQKD-------ELSFSEGEIIILKEYVNEE-WAR 551
Query: 1000 GELNGQKGLVPSNFLEEVPDDVEVYLSDAPSHYSQDTPMRSK 1041
GE+ G+ G+ P NF+E V D Y + + S P+++K
Sbjct: 552 GEVRGRTGIFPLNFVEPVED----YPTSGANVLSTKVPLKTK 589
Score = 47.8 bits (112), Expect = 6e-05
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 43/179 (24%)
Query: 837 EESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYR 896
E+S ++ LPA AL + T ++L FK G I++ D+D + R
Sbjct: 591 EDSGSNSQVNSLPAEWCEALHSFTAET--------SDDLSFKRGDRIQILERLDSD-WCR 641
Query: 897 GETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRR 956
G R G+ P V A+ + M+ ++ +G R+
Sbjct: 642 GRLQDREGIFPAVFVRPCPAEAKSML-AIVPKG-------------------------RK 675
Query: 957 MVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
ALYD+ E EL+F GDIIT +D+D + GEL G+ G+ P N+++
Sbjct: 676 AKALYDFRGEN-------EDELSFKAGDIITELESVDDD-WMSGELMGKSGIFPKNYIQ 726
Score = 31.2 bits (69), Expect = 5.4
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 5/53 (9%)
Query: 181 FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQ 233
F G NE+ EL AG + +D+D + GEL+ G+ G+ P N++ F+Q
Sbjct: 682 FRGENED---ELSFKAGDIITELESVDDD-WMSGELM-GKSGIFPKNYIQFLQ 729
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/222 (23%), Positives = 91/222 (40%), Gaps = 45/222 (20%)
Query: 820 VPSIDDYGRDRLSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKE 879
+ +D++ R R + + + D GA V L D+ P ++L
Sbjct: 449 ITPLDEHLRSRPNDPSHAQKPVDSGAPHA-----VVLHDF--------PAEQVDDLNLTS 495
Query: 880 GQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEK 939
G+I+ + D D +YRG ++G+ P N V I ++ P E
Sbjct: 496 GEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------------------IDIP-EG 535
Query: 940 IERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYY 999
R H V R VA ++Y + EL+F G+II + ++E+ +
Sbjct: 536 GNGKRECVSSHCVKGSRCVARFEYIGEQKD-------ELSFSEGEIIILKEYVNEE-WAR 587
Query: 1000 GELNGQKGLVPSNFLEEVPDDVEVYLSDAPSHYSQDTPMRSK 1041
GE+ G+ G+ P NF+E V D Y + + S P+++K
Sbjct: 588 GEVRGRTGIFPLNFVEPVED----YPTSGANVLSTKVPLKTK 625
Score = 47.8 bits (112), Expect = 6e-05
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 43/179 (24%)
Query: 837 EESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYR 896
E+S ++ LPA AL + T ++L FK G I++ D+D + R
Sbjct: 627 EDSGSNSQVNSLPAEWCEALHSFTAET--------SDDLSFKRGDRIQILERLDSD-WCR 677
Query: 897 GETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRR 956
G R G+ P V A+ + M+ ++ +G R+
Sbjct: 678 GRLQDREGIFPAVFVRPCPAEAKSML-AIVPKG-------------------------RK 711
Query: 957 MVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
ALYD+ E EL+F GDIIT +D+D + GEL G+ G+ P N+++
Sbjct: 712 AKALYDFRGEN-------EDELSFKAGDIITELESVDDD-WMSGELMGKSGIFPKNYIQ 762
Score = 31.2 bits (69), Expect = 5.4
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 5/53 (9%)
Query: 181 FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQ 233
F G NE+ EL AG + +D+D + GEL+ G+ G+ P N++ F+Q
Sbjct: 718 FRGENED---ELSFKAGDIITELESVDDD-WMSGELM-GKSGIFPKNYIQFLQ 765
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/222 (23%), Positives = 91/222 (40%), Gaps = 45/222 (20%)
Query: 820 VPSIDDYGRDRLSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKE 879
+ +D++ R R + + + D GA V L D+ P ++L
Sbjct: 472 ITPLDEHLRSRPNDPSHAQKPVDSGAPHA-----VVLHDF--------PAEQVDDLNLTS 518
Query: 880 GQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEK 939
G+I+ + D D +YRG ++G+ P N V I ++ P E
Sbjct: 519 GEIVYLLEKIDTD-WYRGNCRNQIGIFPANYVKVI------------------IDIP-EG 558
Query: 940 IERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYY 999
R H V R VA ++Y + EL+F G+II + ++E+ +
Sbjct: 559 GNGKRECVSSHCVKGSRCVARFEYIGEQKD-------ELSFSEGEIIILKEYVNEE-WAR 610
Query: 1000 GELNGQKGLVPSNFLEEVPDDVEVYLSDAPSHYSQDTPMRSK 1041
GE+ G+ G+ P NF+E V D Y + + S P+++K
Sbjct: 611 GEVRGRTGIFPLNFVEPVED----YPTSGANVLSTKVPLKTK 648
Score = 47.8 bits (112), Expect = 6e-05
Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 43/179 (24%)
Query: 837 EESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYR 896
E+S ++ LPA AL + T ++L FK G I++ D+D + R
Sbjct: 650 EDSGSNSQVNSLPAEWCEALHSFTAET--------SDDLSFKRGDRIQILERLDSD-WCR 700
Query: 897 GETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRHSVSTRR 956
G R G+ P V A+ + M+ ++ +G R+
Sbjct: 701 GRLQDREGIFPAVFVRPCPAEAKSML-AIVPKG-------------------------RK 734
Query: 957 MVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
ALYD+ E EL+F GDIIT +D+D + GEL G+ G+ P N+++
Sbjct: 735 AKALYDFRGEN-------EDELSFKAGDIITELESVDDD-WMSGELMGKSGIFPKNYIQ 785
Score = 31.2 bits (69), Expect = 5.4
Identities = 19/53 (35%), Positives = 30/53 (56%), Gaps = 5/53 (9%)
Query: 181 FDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFVQ 233
F G NE+ EL AG + +D+D + GEL+ G+ G+ P N++ F+Q
Sbjct: 741 FRGENED---ELSFKAGDIITELESVDDD-WMSGELM-GKSGIFPKNYIQFLQ 788
>gi|109689723 abl interactor 2 [Homo sapiens]
Length = 475
Score = 48.9 bits (115), Expect = 2e-05
Identities = 88/345 (25%), Positives = 115/345 (33%), Gaps = 56/345 (16%)
Query: 587 VPPTPHPRPAPQSKPLASSGVPETKDEHLGPHARMDEAWEQSRAPGPVHGHMLEPPVGPG 646
+P T P P S P++ G LG H+ R PV PPV P
Sbjct: 165 LPRTTPPTQKPPSPPMSGKGT-------LGRHSPY-------RTLEPVR-----PPVVPN 205
Query: 647 RRSPSPSRILPQPQGTPVSTTVAKAMARE-AAQRVAESSRLEKRSVFLERSSAGQYAASD 705
PSP+R + Q +PV T R ++ + S RS E S +G
Sbjct: 206 DYVPSPTRNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPI 265
Query: 706 EEDAYDSPDFKRRGASVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELY 765
SP G V + + HT + G L
Sbjct: 266 AVPT-PSPPSVFPGHPVQFYSMNRPASR----------HTPPTIGGSLPYRRPPSITSQT 314
Query: 766 SEMQLEDGG---RRRPSGTSHNALKILGNPASAGRVDHMGRRFPRGSAGPQRSRPVTVPS 822
S +GG + P + IL + + R S P PV P
Sbjct: 315 SLQNQMNGGPFYSQNPVSLAPPPPSILQVTPQLPLMGFVARVQENISDTPPPPPPVEEPV 374
Query: 823 IDDYGRDRLSPDFYEESE------TDPGAEELPA-------RIFVALFDYDPLTMSPNPD 869
D+ P+ YEE E +DP AEE P VA++DY
Sbjct: 375 FDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTK-------- 426
Query: 870 AAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEI 914
E+EL F+EG II V D DG+Y G GL P N V I
Sbjct: 427 DKEDELSFQEGAIIYVIKKND-DGWYEGVMNGVTGLFPGNYVESI 470
Score = 44.3 bits (103), Expect = 6e-04
Identities = 26/62 (41%), Positives = 36/62 (58%), Gaps = 8/62 (12%)
Query: 956 RMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLE 1015
++VA+YDY D E EL+F G II V + D DG+Y G +NG GL P N++E
Sbjct: 417 KVVAIYDYTK-------DKEDELSFQEGAIIYVIKKND-DGWYEGVMNGVTGLFPGNYVE 468
Query: 1016 EV 1017
+
Sbjct: 469 SI 470
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 48.5 bits (114), Expect = 3e-05
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 911 VSEIQADDEEMMDQLLRQG------FLPLNTPVEKIERSRRSGRRHSVSTRRMVALYDYD 964
+SEI+ E D L + +P + E R+ +R RR + Y
Sbjct: 14 LSEIEIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYL 73
Query: 965 PRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEV 1017
P+ EL GDII V GE++E G++ G LNG+ G+ PSNF++E+
Sbjct: 74 PQNDD-------ELELKVGDIIEVVGEVEE-GWWEGVLNGKTGMFPSNFIKEL 118
Score = 42.7 bits (99), Expect = 0.002
Identities = 21/47 (44%), Positives = 32/47 (68%), Gaps = 1/47 (2%)
Query: 977 ELTFCTGDIITVFGEIDED-GFYYGELNGQKGLVPSNFLEEVPDDVE 1022
ELT GDI+T+ + D G++ GELNG++G+ P NF++ +P D E
Sbjct: 248 ELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 294
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/166 (25%), Positives = 72/166 (43%), Gaps = 32/166 (19%)
Query: 96 LATSLGKGQESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSESDMENE 155
+ S K +A I + ++ P PE KP SG++ SE+ +
Sbjct: 1 MEVSAAKAPSAADLSEIEIKKEMKKDPLTNKAPE----KPLHEVPSGNSLLSSETILRTN 56
Query: 156 RNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGE 215
+ ++R C +SY P + + EL L G + V G+++E G++EG
Sbjct: 57 KRGERRRRR-------CQVAFSYLPQN------DDELELKVGDIIEVVGEVEE-GWWEG- 101
Query: 216 LLDGQRGLVPSNFVDFV-------------QDNESRLASTLGNEQD 248
+L+G+ G+ PSNF+ + Q ++S L T G+E D
Sbjct: 102 VLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESD 147
>gi|24308229 protein kinase C and casein kinase substrate in neurons 1
[Homo sapiens]
Length = 444
Score = 48.5 bits (114), Expect = 3e-05
Identities = 28/63 (44%), Positives = 38/63 (60%), Gaps = 8/63 (12%)
Query: 956 RMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGEL-NGQKGLVPSNFL 1014
R+ ALYDYD +E EL+F GD +T GE DE G+ G L +GQ GL P+N++
Sbjct: 389 RVRALYDYDGQEQD-------ELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYV 441
Query: 1015 EEV 1017
E +
Sbjct: 442 EAI 444
Score = 38.1 bits (87), Expect = 0.044
Identities = 51/202 (25%), Positives = 73/202 (36%), Gaps = 33/202 (16%)
Query: 38 RELEEKCRTQSEQFNLLSRDLEKFRQHAGKIDLLGGSAVAP----LDISTAPSKPFPQFM 93
RELE+ R Q DL FR +G + L +T + P+
Sbjct: 269 RELEQAIRGADAQ-----EDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKA 323
Query: 94 NGLATSLGKG---QESAIGGSSAIGEYIRPLPQPGDRPEPLSAKPTFLSRSGSARCRSES 150
G+A + G S G ++ Y R P + + S P S + E
Sbjct: 324 EGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFGGSETNGGANPFED 383
Query: 151 DMENERNSNTSKQRYSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDG 210
D + R A Y Y DG ++ EL AG L G+ DE G
Sbjct: 384 DSKGVRVR---------------ALYDY---DGQEQD---ELSFKAGDELTKLGEEDEQG 422
Query: 211 FYEGELLDGQRGLVPSNFVDFV 232
+ G L GQ GL P+N+V+ +
Sbjct: 423 WCRGRLDSGQLGLYPANYVEAI 444
Score = 37.7 bits (86), Expect = 0.057
Identities = 39/127 (30%), Positives = 56/127 (44%), Gaps = 19/127 (14%)
Query: 794 SAGRVDHMGRRFPRGSAGP-QRSRPVTVPSIDDYGRDRLSPDFYEESETDPGA---EELP 849
+ G V+ + RGS R +P DD S + + SET+ GA E+
Sbjct: 331 ATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDE-----SGNPFGGSETNGGANPFEDDS 385
Query: 850 ARIFV-ALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGE-TCARLGLIP 907
+ V AL+DYD ++EL FK G + G++D G+ RG +LGL P
Sbjct: 386 KGVRVRALYDYD--------GQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYP 437
Query: 908 CNMVSEI 914
N V I
Sbjct: 438 ANYVEAI 444
>gi|4506929 SH3-domain GRB2-like 1 [Homo sapiens]
Length = 368
Score = 47.0 bits (110), Expect = 9e-05
Identities = 40/130 (30%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 886 YGDKDADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRR 945
Y K + F GE G PC +I A R P+ TP SR
Sbjct: 255 YKPKPREPFDLGEPEQSNGGFPCTTAPKIAASSS------FRSSDKPIRTP------SRS 302
Query: 946 SGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQ 1005
S + ALYD++P + EL F GD+IT+ +IDE+ +Y G L+GQ
Sbjct: 303 MPPLDQPSCK---ALYDFEPEN-------DGELGFHEGDVITLTNQIDEN-WYEGMLDGQ 351
Query: 1006 KGLVPSNFLE 1015
G P +++E
Sbjct: 352 SGFFPLSYVE 361
>gi|47132553 fibronectin 1 isoform 5 preproprotein [Homo sapiens]
Length = 2296
Score = 46.6 bits (109), Expect = 1e-04
Identities = 54/226 (23%), Positives = 92/226 (40%), Gaps = 23/226 (10%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNM 359
PR + ++ S+++ W+ PAV + ++ + + GS++ A I L
Sbjct: 1451 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1510
Query: 360 AACTYRISVQCVTSRGSSDELQCTLLVG-KDVVVAPSHLRVDNITQISAQLSWLPTNSNY 418
Y I+V VT RG S + + + + PS ++V ++ S + WLP++S
Sbjct: 1511 GV-DYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPV 1569
Query: 419 SHVIFL----NEEEFDIVKAA---RYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQRE 471
+ N K A + + L+P + Y V V A+ Q PL Q
Sbjct: 1570 TGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQ-PLVQ-- 1626
Query: 472 KKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTG 517
+T+PA P D+ VTP ++ W PP + TG
Sbjct: 1627 -----TAVTTIPA-----PTDLKF-TQVTPTSLSAQWTPPNVQLTG 1661
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/224 (25%), Positives = 86/224 (38%), Gaps = 27/224 (12%)
Query: 295 DIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALI 354
D VP PR + ++ V + W PP V V + E L + T A +
Sbjct: 905 DTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEV 964
Query: 355 EKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPT 414
L+ TY V V+ S L D AP++L+ N T + + W P
Sbjct: 965 TGLS-PGVTYYFKVFAVSHGRESKPLTAQQTTKLD---APTNLQFVNETDSTVLVRWTPP 1020
Query: 415 N---SNYSHVIFLNE----EEFDIVKAARYKYQFFNLRPNMAYKVKVLA-KPHQMPWQLP 466
+ Y + L ++++ + KY NL+P Y V ++A K +Q
Sbjct: 1021 RAQITGYRLTVGLTRRGQPRQYNVGPSVS-KYPLRNLQPASEYTVSLVAIKGNQ------ 1073
Query: 467 LEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRP 510
E +A F+TL G PP + VT TI ++W P
Sbjct: 1074 ----ESPKATGVFTTLQPGSSIPPYNTE----VTETTIVITWTP 1109
Score = 35.0 bits (79), Expect = 0.37
Identities = 69/299 (23%), Positives = 107/299 (35%), Gaps = 52/299 (17%)
Query: 312 SVIVGWEPPAVP-PGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQC 370
S++V W P P G+ V S +V T +NL + + L + Y I++
Sbjct: 826 SIVVRWSRPQAPITGYRIVYSPSV-EGSSTELNLPETANSVTLSDL--QPGVQYNITIYA 882
Query: 371 VTSRGSSDEL----QCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSHV----- 421
V S + + T D V +P L+ +T + + W P S +
Sbjct: 883 VEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVI 942
Query: 422 -IFLNEEEFDIVKAARYKY-QFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEF 479
+ L E + +R + + L P + Y KV A H RE K +
Sbjct: 943 PVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHG---------RESKPLTAQ- 992
Query: 480 STLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGY----GVYAKGQR 535
T P Q V T +T+ V W PP A +TGY G+ +GQ
Sbjct: 993 QTTKLDAPTNLQFVNE----TDSTVLVRWTPP---------RAQITGYRLTVGLTRRGQP 1039
Query: 536 VAEVIFPTADSTAVELVRLRSLE-AKGVTVRTLSAQGESVDSAVAAV----PPELLVPP 589
+ P +V LR+L+ A TV ++ +G V P +PP
Sbjct: 1040 RQYNVGP-----SVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPP 1093
Score = 34.7 bits (78), Expect = 0.49
Identities = 39/144 (27%), Positives = 62/144 (43%), Gaps = 19/144 (13%)
Query: 430 DIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAP 489
++V A + F NL P + Y V V + +K+ + + +PA PP
Sbjct: 1223 EVVHADQSSCTFDNLSPGLEYNVSVYTV-----------KDDKESVPISDTIIPAVPP-- 1269
Query: 490 PQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAV 549
P D+ + P T+RV+W PP L+N + Y + VAE+ +D+ AV
Sbjct: 1270 PTDLRF-TNIGPDTMRVTWAPP--PSIDLTN--FLVRYSPVKNEEDVAELSISPSDN-AV 1323
Query: 550 ELVRLRSLEAKGVTVRTLSAQGES 573
L L V+V ++ Q ES
Sbjct: 1324 VLTNLLPGTEYVVSVSSVYEQHES 1347
Score = 32.3 bits (72), Expect = 2.4
Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 31/252 (12%)
Query: 276 GITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVL 335
G D+ A + ++I+ E P ++T ++ S+ V W P + P V+ Y V
Sbjct: 1523 GRGDSPASSKPISINYRTEIDKPSQMQVTDVQD--NSISVKWLPSSSP-----VTGYRVT 1575
Query: 336 VDKE-----TRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDV 390
+ T+ +T+ IE L Y +SV G S L T +
Sbjct: 1576 TTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV-EYVVSVYAQNPSGESQPLVQTAVT---T 1631
Query: 391 VVAPSHLRVDNITQISAQLSWLPTNSNYS--HVIFLNEEEFDIVKAARYKYQFFNLRPNM 448
+ AP+ L+ +T S W P N + V +E+ +K NL P+
Sbjct: 1632 IPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKE-------INLAPDS 1684
Query: 449 AYKV---KVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIR 505
+ V ++A +++ + + A +TL +PP+ V T TI
Sbjct: 1685 SSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLE--NVSPPRRARV-TDATETTIT 1741
Query: 506 VSWRPPVLTPTG 517
+SWR T TG
Sbjct: 1742 ISWRTKTETITG 1753
>gi|47132549 fibronectin 1 isoform 6 preproprotein [Homo sapiens]
Length = 2176
Score = 46.6 bits (109), Expect = 1e-04
Identities = 54/226 (23%), Positives = 92/226 (40%), Gaps = 23/226 (10%)
Query: 300 PRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNM 359
PR + ++ S+++ W+ PAV + ++ + + GS++ A I L
Sbjct: 1451 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1510
Query: 360 AACTYRISVQCVTSRGSSDELQCTLLVG-KDVVVAPSHLRVDNITQISAQLSWLPTNSNY 418
Y I+V VT RG S + + + + PS ++V ++ S + WLP++S
Sbjct: 1511 GV-DYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPV 1569
Query: 419 SHVIFL----NEEEFDIVKAA---RYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQRE 471
+ N K A + + L+P + Y V V A+ Q PL Q
Sbjct: 1570 TGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQ-PLVQ-- 1626
Query: 472 KKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTG 517
+T+PA P D+ VTP ++ W PP + TG
Sbjct: 1627 -----TAVTTIPA-----PTDLKF-TQVTPTSLSAQWTPPNVQLTG 1661
Score = 45.4 bits (106), Expect = 3e-04
Identities = 56/224 (25%), Positives = 86/224 (38%), Gaps = 27/224 (12%)
Query: 295 DIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMNLTLGSRTKALI 354
D VP PR + ++ V + W PP V V + E L + T A +
Sbjct: 905 DTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEV 964
Query: 355 EKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPT 414
L+ TY V V+ S L D AP++L+ N T + + W P
Sbjct: 965 TGLS-PGVTYYFKVFAVSHGRESKPLTAQQTTKLD---APTNLQFVNETDSTVLVRWTPP 1020
Query: 415 N---SNYSHVIFLNE----EEFDIVKAARYKYQFFNLRPNMAYKVKVLA-KPHQMPWQLP 466
+ Y + L ++++ + KY NL+P Y V ++A K +Q
Sbjct: 1021 RAQITGYRLTVGLTRRGQPRQYNVGPSVS-KYPLRNLQPASEYTVSLVAIKGNQ------ 1073
Query: 467 LEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIRVSWRP 510
E +A F+TL G PP + VT TI ++W P
Sbjct: 1074 ----ESPKATGVFTTLQPGSSIPPYNTE----VTETTIVITWTP 1109
Score = 35.0 bits (79), Expect = 0.37
Identities = 69/299 (23%), Positives = 107/299 (35%), Gaps = 52/299 (17%)
Query: 312 SVIVGWEPPAVP-PGWGTVSSYNVLVDKETRMNLTLGSRTKALIEKLNMAACTYRISVQC 370
S++V W P P G+ V S +V T +NL + + L + Y I++
Sbjct: 826 SIVVRWSRPQAPITGYRIVYSPSV-EGSSTELNLPETANSVTLSDL--QPGVQYNITIYA 882
Query: 371 VTSRGSSDEL----QCTLLVGKDVVVAPSHLRVDNITQISAQLSWLPTNSNYSHV----- 421
V S + + T D V +P L+ +T + + W P S +
Sbjct: 883 VEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVI 942
Query: 422 -IFLNEEEFDIVKAARYKY-QFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEF 479
+ L E + +R + + L P + Y KV A H RE K +
Sbjct: 943 PVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHG---------RESKPLTAQ- 992
Query: 480 STLPAGPPAPPQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGY----GVYAKGQR 535
T P Q V T +T+ V W PP A +TGY G+ +GQ
Sbjct: 993 QTTKLDAPTNLQFVNE----TDSTVLVRWTPP---------RAQITGYRLTVGLTRRGQP 1039
Query: 536 VAEVIFPTADSTAVELVRLRSLE-AKGVTVRTLSAQGESVDSAVAAV----PPELLVPP 589
+ P +V LR+L+ A TV ++ +G V P +PP
Sbjct: 1040 RQYNVGP-----SVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPP 1093
Score = 34.7 bits (78), Expect = 0.49
Identities = 39/144 (27%), Positives = 62/144 (43%), Gaps = 19/144 (13%)
Query: 430 DIVKAARYKYQFFNLRPNMAYKVKVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAP 489
++V A + F NL P + Y V V + +K+ + + +PA PP
Sbjct: 1223 EVVHADQSSCTFDNLSPGLEYNVSVYTV-----------KDDKESVPISDTIIPAVPP-- 1269
Query: 490 PQDVTVQAGVTPATIRVSWRPPVLTPTGLSNGANVTGYGVYAKGQRVAEVIFPTADSTAV 549
P D+ + P T+RV+W PP L+N + Y + VAE+ +D+ AV
Sbjct: 1270 PTDLRF-TNIGPDTMRVTWAPP--PSIDLTN--FLVRYSPVKNEEDVAELSISPSDN-AV 1323
Query: 550 ELVRLRSLEAKGVTVRTLSAQGES 573
L L V+V ++ Q ES
Sbjct: 1324 VLTNLLPGTEYVVSVSSVYEQHES 1347
Score = 32.3 bits (72), Expect = 2.4
Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 31/252 (12%)
Query: 276 GITDNSAGTLDVNIDDIGEDIVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVL 335
G D+ A + ++I+ E P ++T ++ S+ V W P + P V+ Y V
Sbjct: 1523 GRGDSPASSKPISINYRTEIDKPSQMQVTDVQD--NSISVKWLPSSSP-----VTGYRVT 1575
Query: 336 VDKE-----TRMNLTLGSRTKALIEKLNMAACTYRISVQCVTSRGSSDELQCTLLVGKDV 390
+ T+ +T+ IE L Y +SV G S L T +
Sbjct: 1576 TTPKNGPGPTKTKTAGPDQTEMTIEGLQPTV-EYVVSVYAQNPSGESQPLVQTAVT---T 1631
Query: 391 VVAPSHLRVDNITQISAQLSWLPTNSNYS--HVIFLNEEEFDIVKAARYKYQFFNLRPNM 448
+ AP+ L+ +T S W P N + V +E+ +K NL P+
Sbjct: 1632 IPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKE-------INLAPDS 1684
Query: 449 AYKV---KVLAKPHQMPWQLPLEQREKKEAFVEFSTLPAGPPAPPQDVTVQAGVTPATIR 505
+ V ++A +++ + + A +TL +PP+ V T TI
Sbjct: 1685 SSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTTLE--NVSPPRRARV-TDATETTIT 1741
Query: 506 VSWRPPVLTPTG 517
+SWR T TG
Sbjct: 1742 ISWRTKTETITG 1753
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 33/152 (21%)
Query: 873 EELPFKEGQIIKVYGDKDADGFYRGETCAR-----LGLIPCNMVSEIQADDEEMMDQLLR 927
E+L GQ+I + K+ G++ GE AR +G P N V +LL
Sbjct: 1091 EQLTLAPGQLILIR-KKNPGGWWEGELQARGKKRQIGWFPANYV------------KLLS 1137
Query: 928 QGFLPLNTPVEKIERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIIT 987
G + TP E + + + + +++ +YDY + EL F G II
Sbjct: 1138 PGTSKI-TPTEPPKSTALA------AVCQVIGMYDYTAQNDD-------ELAFNKGQIIN 1183
Query: 988 VFGEIDEDGFYYGELNGQKGLVPSNFLEEVPD 1019
V + D D ++ GE+NGQ GL PSN+++ D
Sbjct: 1184 VLNKEDPD-WWKGEVNGQVGLFPSNYVKLTTD 1214
Score = 39.7 bits (91), Expect = 0.015
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 14/93 (15%)
Query: 959 ALYDYDPRESSPNVDVEAELTFCTGDIITVFGE-IDED-----GFYYGELNGQKGLVPSN 1012
ALY ++ R E+T GDI+ V GE +DE G+ GEL G+ G P+N
Sbjct: 747 ALYPFESRSHD-------EITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPAN 799
Query: 1013 FLEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRK 1045
+ E++P++ EV P S P A R+
Sbjct: 800 YAEKIPEN-EVPAPVKPVTDSTSAPAPKLALRE 831
Score = 37.4 bits (85), Expect = 0.075
Identities = 25/81 (30%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Query: 831 LSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKD 890
LSP + + T+P A + + YD + ++EL F +GQII V +D
Sbjct: 1136 LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQN------DDELAFNKGQIINVLNKED 1189
Query: 891 ADGFYRGETCARLGLIPCNMV 911
D +++GE ++GL P N V
Sbjct: 1190 PD-WWKGEVNGQVGLFPSNYV 1209
Score = 32.3 bits (72), Expect = 2.4
Identities = 19/69 (27%), Positives = 36/69 (52%), Gaps = 9/69 (13%)
Query: 947 GRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQK 1006
G+ V + ALY + ++ + L F D+ITV + +D +++GE+ GQK
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDN-------HLNFNKNDVITVLEQ--QDMWWFGEVQGQK 958
Query: 1007 GLVPSNFLE 1015
G P ++++
Sbjct: 959 GWFPKSYVK 967
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 33/152 (21%)
Query: 873 EELPFKEGQIIKVYGDKDADGFYRGETCAR-----LGLIPCNMVSEIQADDEEMMDQLLR 927
E+L GQ+I + K+ G++ GE AR +G P N V +LL
Sbjct: 1091 EQLTLAPGQLILIR-KKNPGGWWEGELQARGKKRQIGWFPANYV------------KLLS 1137
Query: 928 QGFLPLNTPVEKIERSRRSGRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIIT 987
G + TP E + + + + +++ +YDY + EL F G II
Sbjct: 1138 PGTSKI-TPTEPPKSTALA------AVCQVIGMYDYTAQNDD-------ELAFNKGQIIN 1183
Query: 988 VFGEIDEDGFYYGELNGQKGLVPSNFLEEVPD 1019
V + D D ++ GE+NGQ GL PSN+++ D
Sbjct: 1184 VLNKEDPD-WWKGEVNGQVGLFPSNYVKLTTD 1214
Score = 39.7 bits (91), Expect = 0.015
Identities = 31/93 (33%), Positives = 45/93 (48%), Gaps = 14/93 (15%)
Query: 959 ALYDYDPRESSPNVDVEAELTFCTGDIITVFGE-IDED-----GFYYGELNGQKGLVPSN 1012
ALY ++ R E+T GDI+ V GE +DE G+ GEL G+ G P+N
Sbjct: 747 ALYPFESRSHD-------EITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPAN 799
Query: 1013 FLEEVPDDVEVYLSDAPSHYSQDTPMRSKAKRK 1045
+ E++P++ EV P S P A R+
Sbjct: 800 YAEKIPEN-EVPAPVKPVTDSTSAPAPKLALRE 831
Score = 39.3 bits (90), Expect = 0.020
Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 12/122 (9%)
Query: 831 LSPDFYEESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKD 890
LSP + + T+P A + + YD + ++EL F +GQII V +D
Sbjct: 1136 LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQN------DDELAFNKGQIINVLNKED 1189
Query: 891 ADGFYRGETCARLGLIPCNMVSEIQADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRRH 950
D +++GE ++GL P N V ++ D + L + TP E+ +R G H
Sbjct: 1190 PD-WWKGEVNGQVGLFPSNYV-KLTTDMDPSQQWCSDLHLLDMLTPTER----KRQGYIH 1243
Query: 951 SV 952
+
Sbjct: 1244 EL 1245
Score = 32.3 bits (72), Expect = 2.4
Identities = 19/69 (27%), Positives = 36/69 (52%), Gaps = 9/69 (13%)
Query: 947 GRRHSVSTRRMVALYDYDPRESSPNVDVEAELTFCTGDIITVFGEIDEDGFYYGELNGQK 1006
G+ V + ALY + ++ + L F D+ITV + +D +++GE+ GQK
Sbjct: 908 GQGEKVEGLQAQALYPWRAKKDN-------HLNFNKNDVITVLEQ--QDMWWFGEVQGQK 958
Query: 1007 GLVPSNFLE 1015
G P ++++
Sbjct: 959 GWFPKSYVK 967
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,363,239
Number of Sequences: 37866
Number of extensions: 2521554
Number of successful extensions: 12331
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 85
Number of HSP's successfully gapped in prelim test: 496
Number of HSP's that attempted gapping in prelim test: 10530
Number of HSP's gapped (non-prelim): 2058
length of query: 1052
length of database: 18,247,518
effective HSP length: 113
effective length of query: 939
effective length of database: 13,968,660
effective search space: 13116571740
effective search space used: 13116571740
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.