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Search of human proteins with 14042966
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|14042966 testis-specific serine kinase 6 [Homo sapiens]
(273 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|14042966 testis-specific serine kinase 6 [Homo sapiens] 555 e-158
gi|16418343 testis-specific serine kinase 3 [Homo sapiens] 243 1e-64
gi|14042947 testis-specific serine kinase 1 [Homo sapiens] 241 4e-64
gi|194294513 testis-specific serine kinase 2 [Homo sapiens] 240 8e-64
gi|42734401 testis-specific serine kinase 4 [Homo sapiens] 200 1e-51
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 179 3e-45
gi|116256471 SNF1-like kinase [Homo sapiens] 177 7e-45
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 175 4e-44
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 172 2e-43
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 172 2e-43
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 172 2e-43
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 172 2e-43
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor... 171 6e-43
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor... 171 6e-43
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor... 171 6e-43
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor... 171 6e-43
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform... 171 6e-43
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens] 167 7e-42
gi|38569460 SNF1-like kinase 2 [Homo sapiens] 159 3e-39
gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens] 153 1e-37
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens] 153 1e-37
gi|46877068 AMP-activated protein kinase alpha 2 catalytic subun... 153 2e-37
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 153 2e-37
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 152 4e-37
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 150 9e-37
gi|156105707 SNF related kinase [Homo sapiens] 149 2e-36
gi|156105705 SNF related kinase [Homo sapiens] 149 2e-36
gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic sub... 147 1e-35
gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens] 146 2e-35
gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens] 146 2e-35
>gi|14042966 testis-specific serine kinase 6 [Homo sapiens]
Length = 273
Score = 555 bits (1429), Expect = e-158
Identities = 273/273 (100%), Positives = 273/273 (100%)
Query: 1 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 60
MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE
Sbjct: 1 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 60
Query: 61 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIA 120
LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIA
Sbjct: 61 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIA 120
Query: 121 GAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASP 180
GAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASP
Sbjct: 121 GAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASP 180
Query: 181 EVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERC 240
EVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERC
Sbjct: 181 EVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERC 240
Query: 241 KALIAELLQFSPSARPSAGQVARNCWLRAGDSG 273
KALIAELLQFSPSARPSAGQVARNCWLRAGDSG
Sbjct: 241 KALIAELLQFSPSARPSAGQVARNCWLRAGDSG 273
>gi|16418343 testis-specific serine kinase 3 [Homo sapiens]
Length = 268
Score = 243 bits (620), Expect = 1e-64
Identities = 131/266 (49%), Positives = 179/266 (67%), Gaps = 5/266 (1%)
Query: 4 DKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSI 63
D LLS GY+LG+TIGEG+YSKVK A SKK++ VAIKV+D+ P +F+ +FLPREL I
Sbjct: 3 DFLLSN-GYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKVIDKMGGPEEFIQRFLPRELQI 61
Query: 64 LRGVRHPHIVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQRNGRIPGVQARDLFAQIAGA 122
+R + H +I+ V+E +E +GK+ +VME A D+ V G +P +A+ LF Q+ A
Sbjct: 62 VRTLDHKNIIQVYEMLESADGKICLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEA 121
Query: 123 VRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQA-HGYPDLSTTYCGSAAYASPE 181
+RY H + HRDLKCEN LL +KLTDFGF + + +LS T+CGS AYA+PE
Sbjct: 122 IRYCHGCGVAHRDLKCENALLQGFN--LKLTDFGFAKVLPKSHRELSQTFCGSTAYAAPE 179
Query: 182 VLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCK 241
VL GIP+D KK DVWSMGVVLYVM+ +PFDD+DI + +Q++GV +P L +S C+
Sbjct: 180 VLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLSISADCQ 239
Query: 242 ALIAELLQFSPSARPSAGQVARNCWL 267
L+ LL+ RPS +V+ + WL
Sbjct: 240 DLLKRLLEPDMILRPSIEEVSWHPWL 265
>gi|14042947 testis-specific serine kinase 1 [Homo sapiens]
Length = 367
Score = 241 bits (616), Expect = 4e-64
Identities = 128/274 (46%), Positives = 176/274 (64%), Gaps = 7/274 (2%)
Query: 1 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 60
M +L GY LG +GEGSY+KVK A S++ K VAIK++DR++AP DF+ KFLPRE
Sbjct: 1 MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE 60
Query: 61 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQI 119
+ IL + H I+ +E E +GK+YIVME A DLL+ ++ G + +AR F Q+
Sbjct: 61 IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL 120
Query: 120 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA 175
+ A++Y HD +VHRDLKC+N+LL D +KL+DF F R G LS T+CGS
Sbjct: 121 SLAIKYCHDLDVVHRDLKCDNLLLDKD-FNIKLSDFSFSKRCLRDDSGRMALSKTFCGSP 179
Query: 176 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQK-RGVLYPEGL 234
AYA+PEVL GIPY PK YD+WS+GV+LY+MV G MP+DDS+I + R QK V +P
Sbjct: 180 AYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSK 239
Query: 235 ELSERCKALIAELLQFSPSARPSAGQVARNCWLR 268
L+ CK LI +LQ + R ++ +CW++
Sbjct: 240 HLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQ 273
>gi|194294513 testis-specific serine kinase 2 [Homo sapiens]
Length = 358
Score = 240 bits (613), Expect = 8e-64
Identities = 127/274 (46%), Positives = 177/274 (64%), Gaps = 7/274 (2%)
Query: 1 MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRE 60
M +L + GY +G +G+GSY+KVK A S++ K VA+K++DR++ P DFV +FLPRE
Sbjct: 1 MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPRE 60
Query: 61 LSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQI 119
+ IL V H I+ +E E +G++YI+ME DLL+ ++ G + AR +F Q+
Sbjct: 61 MDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQL 120
Query: 120 AGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG----RQAHGYPDLSTTYCGSA 175
+ AV+Y HD +VHRDLKCEN+LL D +KL+DFGF R ++G LS T+CGSA
Sbjct: 121 SSAVKYCHDLDIVHRDLKCENLLLDKDFN-IKLSDFGFSKRCLRDSNGRIILSKTFCGSA 179
Query: 176 AYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQK-RGVLYPEGL 234
AYA+PEVL IPY PK YD+WS+GV+LY+MV G MP+DDSDI + R QK V +P
Sbjct: 180 AYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSK 239
Query: 235 ELSERCKALIAELLQFSPSARPSAGQVARNCWLR 268
L+ CK LI +LQ S R ++ + WL+
Sbjct: 240 NLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQ 273
>gi|42734401 testis-specific serine kinase 4 [Homo sapiens]
Length = 328
Score = 200 bits (508), Expect = 1e-51
Identities = 106/278 (38%), Positives = 167/278 (60%), Gaps = 19/278 (6%)
Query: 6 LLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILR 65
L+ E GY++G+ IG GSY V A K K VA+K++ +++A D++NKFLPRE+ +++
Sbjct: 19 LMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMK 78
Query: 66 GVRHPHIVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVR 124
+RH ++++ + IE ++YI++E A D+L+ +QR G A F+Q+ +
Sbjct: 79 VLRHKYLINFYRAIE-STSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIA 137
Query: 125 YLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFG---------------RQAHGYPDLST 169
YLH +VHRDLK EN+LL E VK++DFGF RQ + + LS
Sbjct: 138 YLHSKSIVHRDLKLENLLLDKWE-NVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQ 196
Query: 170 TYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVL 229
TYCGS AYA PE+L G+PY+P D WSMGV+LY +V +PFDD+++ L R ++ V
Sbjct: 197 TYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVT 256
Query: 230 YPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWL 267
+P +S+ CK LI ++L+ + R + + ++ W+
Sbjct: 257 FPANHTISQECKNLILQMLR-QATKRATILDIIKDSWV 293
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 179 bits (453), Expect = 3e-45
Identities = 102/263 (38%), Positives = 157/263 (59%), Gaps = 6/263 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L RTIG+G+++KVK+A VAIK++D+ + P + K RE+ I++G+ HP+
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLF-REVRIMKGLNHPN 117
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+A ++ + +GR+ +AR F QI AV Y H +
Sbjct: 118 IVKLFEVIET-EKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKN 176
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL E +K+ DFGF + L T+CGS YA+PE+ G YD
Sbjct: 177 IVHRDLKAENLLLDA-EANIKIADFGFSNEFTLGSKLD-TFCGSPPYAAPELFQGKKYDG 234
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ D+WS+GV+LY +V+G +PFD ++ L R RG Y +S C++++ L
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRG-KYRVPFYMSTDCESILRRFLVL 293
Query: 251 SPSARPSAGQVARNCWLRAGDSG 273
+P+ R + Q+ ++ W+ G G
Sbjct: 294 NPAKRCTLEQIMKDKWINIGYEG 316
>gi|116256471 SNF1-like kinase [Homo sapiens]
Length = 783
Score = 177 bits (450), Expect = 7e-45
Identities = 101/259 (38%), Positives = 154/259 (59%), Gaps = 6/259 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y + RT+G+G+++ VK+A + K VAIK++D+ R + K RE+ +++ + HPH
Sbjct: 27 YDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIY-REVQLMKLLNHPH 85
Query: 72 IVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
I+ +++ +E LYIV E A ++ + NG + +AR F QI AV Y HDHH
Sbjct: 86 IIKLYQVMET-KDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHH 144
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL +KL DFGFG LS T+CGS YA+PEV G Y+
Sbjct: 145 IVHRDLKTENLLLD-GNMDIKLADFGFGNFYKSGEPLS-TWCGSPPYAAPEVFEGKEYEG 202
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ D+WS+GVVLYV+V G +PFD ++ L +R G + +S+ C++LI +L
Sbjct: 203 PQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEG-RFRIPFFMSQDCESLIRRMLVV 261
Query: 251 SPSARPSAGQVARNCWLRA 269
P+ R + Q+ ++ W+RA
Sbjct: 262 DPARRITIAQIRQHRWMRA 280
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 175 bits (443), Expect = 4e-44
Identities = 101/260 (38%), Positives = 155/260 (59%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VA+K++D+ + P + K RE+ I++ + HP+
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 118
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+ ++ + +GR+ +AR F QI AV+Y H +
Sbjct: 119 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKY 177
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + L T+CGS YA+PE+ G YD
Sbjct: 178 IVHRDLKAENLLLDGD-MNIKIADFGFSNEFTVGNKLD-TFCGSPPYAAPELFQGKKYDG 235
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ +LL
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKLLVL 294
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P R S Q+ ++ W+ G
Sbjct: 295 NPIKRGSLEQIMKDRWMNVG 314
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 172 bits (437), Expect = 2e-43
Identities = 100/260 (38%), Positives = 153/260 (58%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VAIK++D+ + P + K RE+ I++ + HP+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY++ME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + L T+CGS YA+PE+ G YD
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLD-TFCGSPPYAAPELFQGKKYDG 231
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P R + Q+ ++ W+ AG
Sbjct: 291 NPIKRGTLEQIMKDRWINAG 310
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 172 bits (437), Expect = 2e-43
Identities = 100/260 (38%), Positives = 153/260 (58%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VAIK++D+ + P + K RE+ I++ + HP+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY++ME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + L T+CGS YA+PE+ G YD
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLD-TFCGSPPYAAPELFQGKKYDG 231
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P R + Q+ ++ W+ AG
Sbjct: 291 NPIKRGTLEQIMKDRWINAG 310
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 172 bits (437), Expect = 2e-43
Identities = 100/260 (38%), Positives = 153/260 (58%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VAIK++D+ + P + K RE+ I++ + HP+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY++ME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + L T+CGS YA+PE+ G YD
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLD-TFCGSPPYAAPELFQGKKYDG 231
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P R + Q+ ++ W+ AG
Sbjct: 291 NPIKRGTLEQIMKDRWINAG 310
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 172 bits (437), Expect = 2e-43
Identities = 100/260 (38%), Positives = 153/260 (58%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VAIK++D+ + P + K RE+ I++ + HP+
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLF-REVRIMKILNHPN 114
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY++ME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 115 IVKLFEVIET-EKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKR 173
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + L T+CGS YA+PE+ G YD
Sbjct: 174 IVHRDLKAENLLLDAD-MNIKIADFGFSNEFTVGGKLD-TFCGSPPYAAPELFQGKKYDG 231
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ L
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKRFLVL 290
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P R + Q+ ++ W+ AG
Sbjct: 291 NPIKRGTLEQIMKDRWINAG 310
>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
[Homo sapiens]
Length = 709
Score = 171 bits (433), Expect = 6e-43
Identities = 98/260 (37%), Positives = 154/260 (59%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VA+K++D+ + + K RE+ I++ + HP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + + + T+CGS YA+PE+ G YD
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNE-FTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 251 SPSARPSAGQVARNCWLRAG 270
+PS R + Q+ ++ W+ G
Sbjct: 288 NPSKRGTLEQIMKDRWMNVG 307
>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
[Homo sapiens]
Length = 719
Score = 171 bits (433), Expect = 6e-43
Identities = 98/260 (37%), Positives = 154/260 (59%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VA+K++D+ + + K RE+ I++ + HP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + + + T+CGS YA+PE+ G YD
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNE-FTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 251 SPSARPSAGQVARNCWLRAG 270
+PS R + Q+ ++ W+ G
Sbjct: 288 NPSKRGTLEQIMKDRWMNVG 307
>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
[Homo sapiens]
Length = 788
Score = 171 bits (433), Expect = 6e-43
Identities = 98/260 (37%), Positives = 154/260 (59%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VA+K++D+ + + K RE+ I++ + HP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + + + T+CGS YA+PE+ G YD
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNE-FTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 251 SPSARPSAGQVARNCWLRAG 270
+PS R + Q+ ++ W+ G
Sbjct: 288 NPSKRGTLEQIMKDRWMNVG 307
>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
[Homo sapiens]
Length = 724
Score = 171 bits (433), Expect = 6e-43
Identities = 98/260 (37%), Positives = 154/260 (59%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VA+K++D+ + + K RE+ I++ + HP+
Sbjct: 53 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 111
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 112 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 170
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + + + T+CGS YA+PE+ G YD
Sbjct: 171 IVHRDLKAENLLLDAD-MNIKIADFGFSNE-FTFGNKLDTFCGSPPYAAPELFQGKKYDG 228
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ + L
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 287
Query: 251 SPSARPSAGQVARNCWLRAG 270
+PS R + Q+ ++ W+ G
Sbjct: 288 NPSKRGTLEQIMKDRWMNVG 307
>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
[Homo sapiens]
Length = 745
Score = 171 bits (433), Expect = 6e-43
Identities = 98/260 (37%), Positives = 154/260 (59%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +TIG+G+++KVK+A VA+K++D+ + + K RE+ I++ + HP+
Sbjct: 20 YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLF-REVRIMKVLNHPN 78
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
IV +FE IE LY+VME A+ ++ + +GR+ +AR F QI AV+Y H
Sbjct: 79 IVKLFEVIET-EKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKF 137
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFGF + + + T+CGS YA+PE+ G YD
Sbjct: 138 IVHRDLKAENLLLDAD-MNIKIADFGFSNE-FTFGNKLDTFCGSPPYAAPELFQGKKYDG 195
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ DVWS+GV+LY +V+G +PFD ++ L R RG Y +S C+ L+ + L
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRG-KYRIPFYMSTDCENLLKKFLIL 254
Query: 251 SPSARPSAGQVARNCWLRAG 270
+PS R + Q+ ++ W+ G
Sbjct: 255 NPSKRGTLEQIMKDRWMNVG 274
>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
Length = 1263
Score = 167 bits (424), Expect = 7e-42
Identities = 97/262 (37%), Positives = 153/262 (58%), Gaps = 6/262 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y++ RTIG+G+++ VK AT K VAIK++D+ + + + K RE+ I++ + HPH
Sbjct: 8 YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF-REVQIMKMLCHPH 66
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
I+ +++ +E +Y+V E A+ ++ + +GR+ +AR F QI AV + H +
Sbjct: 67 IIRLYQVMET-ERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRN 125
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL + +K+ DFGF L T+CGS YA+PE+ G YD
Sbjct: 126 IVHRDLKAENLLLDAN-LNIKIADFGFSN-LFTPGQLLKTWCGSPPYAAPELFEGKEYDG 183
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
K D+WS+GVVLYV+V G +PFD S + L R G + +S C+ LI +L
Sbjct: 184 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSG-KFRIPFFMSTECEHLIRHMLVL 242
Query: 251 SPSARPSAGQVARNCWLRAGDS 272
P+ R S Q+ ++ W++ GD+
Sbjct: 243 DPNKRLSMEQICKHKWMKLGDA 264
>gi|38569460 SNF1-like kinase 2 [Homo sapiens]
Length = 926
Score = 159 bits (401), Expect = 3e-39
Identities = 96/258 (37%), Positives = 149/258 (57%), Gaps = 8/258 (3%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVN-KFLPRELSILRGVRHP 70
Y + T+G+G+++ VK+ + K VAIK++D+ + D VN + + RE+ I++ + HP
Sbjct: 20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQL--DAVNLEKIYREVQIMKMLDHP 77
Query: 71 HIVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDH 129
HI+ +++ +E LY+V E A ++ + +GR+ +AR F QI AV Y H
Sbjct: 78 HIIKLYQVMET-KSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGR 136
Query: 130 HLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYD 189
+VHRDLK EN+LL + +K+ DFGFG +L T+CGS YA+PEV G Y+
Sbjct: 137 KIVHRDLKAENLLLD-NNMNIKIADFGFGNFFKS-GELLATWCGSPPYAAPEVFEGQQYE 194
Query: 190 PKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQ 249
+ D+WSMGVVLYV+V G +PFD + L +R G + +SE C+ LI +L
Sbjct: 195 GPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEG-RFRIPYFMSEDCEHLIRRMLV 253
Query: 250 FSPSARPSAGQVARNCWL 267
PS R + Q+ + W+
Sbjct: 254 LDPSKRLTIAQIKEHKWM 271
>gi|13569922 NUAK family, SNF1-like kinase, 2 [Homo sapiens]
Length = 628
Score = 153 bits (387), Expect = 1e-37
Identities = 97/260 (37%), Positives = 142/260 (54%), Gaps = 7/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+ T+G+G+Y KVK A + VAIK + + + + + RE+ I+ + HPH
Sbjct: 53 YEFLETLGKGTYGKVKKARESSGR-LVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPH 111
Query: 72 IVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
I+ + E E + K+ IVME A+ DL + ++ +AR F QI AV Y H +
Sbjct: 112 IIAIHEVFEN-SSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNR 170
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL + +K+ DFG H L T+CGS YASPE++ G PY
Sbjct: 171 VVHRDLKLENILLDAN-GNIKIADFGLSNLYHQGKFLQ-TFCGSPLYASPEIVNGKPYTG 228
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ D WS+GV+LY++V G MPFD D L ++ G Y E + S+ C LI LL
Sbjct: 229 PEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGA-YREPPKPSDAC-GLIRWLLMV 286
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P+ R + VA + W+ G
Sbjct: 287 NPTRRATLEDVASHWWVNWG 306
>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
Length = 661
Score = 153 bits (387), Expect = 1e-37
Identities = 93/260 (35%), Positives = 140/260 (53%), Gaps = 6/260 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L T+G+G+Y KVK AT + VAIK + + + + + RE+ I+ + HPH
Sbjct: 55 YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114
Query: 72 IVHVFEFIEVCNGKLYIVMEAAAT-DLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
I+ ++E E K+ I+ME A+ +L + R+ + R F QI AV Y H +
Sbjct: 115 IISIYEVFEN-KDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNG 173
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK EN+LL D +K+ DFG + T+CGS YASPE++ G PY
Sbjct: 174 VVHRDLKLENILLD-DNCNIKIADFGLS-NLYQKDKFLQTFCGSPLYASPEIVNGRPYRG 231
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ D W++GV+LY +V G MPFD D L R+ G Y E + S+ + LI +L
Sbjct: 232 PEVDSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGE-YREPTQPSD-ARGLIRWMLMV 289
Query: 251 SPSARPSAGQVARNCWLRAG 270
+P R + +A + W+ G
Sbjct: 290 NPDRRATIEDIANHWWVNWG 309
>gi|46877068 AMP-activated protein kinase alpha 2 catalytic subunit
[Homo sapiens]
Length = 552
Score = 153 bits (386), Expect = 2e-37
Identities = 92/259 (35%), Positives = 141/259 (54%), Gaps = 7/259 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPP-DFVNKFLPRELSILRGVRHP 70
Y LG T+G G++ KVK+ + VA+K+++R++ D V K + RE+ L+ RHP
Sbjct: 16 YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK-IKREIQNLKLFRHP 74
Query: 71 HIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
HI+ +++ I ++ + +L + ++GR+ ++AR LF QI AV Y H H
Sbjct: 75 HIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHM 134
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK ENVLL K+ DFG L T+ CGS YA+PEV+ G Y
Sbjct: 135 VVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 192
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLY-PEGLELSERCKALIAELLQ 249
+ D+WS GV+LY ++ G +PFDD + L ++ + GV Y PE L S L+ +LQ
Sbjct: 193 PEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS--VATLLMHMLQ 250
Query: 250 FSPSARPSAGQVARNCWLR 268
P R + + + W +
Sbjct: 251 VDPLKRATIKDIREHEWFK 269
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 153 bits (386), Expect = 2e-37
Identities = 102/269 (37%), Positives = 146/269 (54%), Gaps = 10/269 (3%)
Query: 12 YKLG-RTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPD-FVNKFLPRELSILRGVRH 69
Y +G R +GEGS++KV+ VAIKV+D++RA D +V K L RE I + +RH
Sbjct: 61 YLIGSRKLGEGSFAKVREGLHVLTGEKVAIKVIDKKRAKKDTYVTKNLRREGQIQQMIRH 120
Query: 70 PHIVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHD 128
P+I + + +E N Y+VME +L+ + R+ +AR Q+ AV +LH
Sbjct: 121 PNITQLLDILETENS-YYLVMELCPGGNLMHKIYEKKRLEESEARRYIRQLISAVEHLHR 179
Query: 129 HHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAH--GYPDLSTTYCGSAAYASPEVLLGI 186
+VHRDLK EN+LL D +KL DFG A GY D +T CGS AYA+PE+L
Sbjct: 180 AGVVHRDLKIENLLLDED-NNIKLIDFGLSNCAGILGYSDPFSTQCGSPAYAAPELLARK 238
Query: 187 PYDPKKYDVWSMGVVLYVMVTGCMPF--DDSDIAGLPRRQKRGVLYPEGLELSERCKALI 244
Y P K DVWS+GV +Y M+TG +PF + + L ++ + P +LS + +
Sbjct: 239 KYGP-KIDVWSIGVNMYAMLTGTLPFTVEPFSLRALYQKMVDKEMNPLPTQLSTGAISFL 297
Query: 245 AELLQFSPSARPSAGQVARNCWLRAGDSG 273
LL+ P RP+ Q N WL +G
Sbjct: 298 RSLLEPDPVKRPNIQQALANRWLNENYTG 326
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 152 bits (383), Expect = 4e-37
Identities = 88/261 (33%), Positives = 147/261 (56%), Gaps = 8/261 (3%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +T+G+G VK+ VAIK+V+R + + K + RE++IL+ + HPH
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 92
Query: 72 IVHVFEFIEVCNGK-LYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDH 129
++ + + E N K LY+V+E + +L + + GR+ +AR F QI A+ + H +
Sbjct: 93 VLKLHDVYE--NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSY 150
Query: 130 HLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYD 189
+ HRDLK EN+LL ++ +++ DFG G L T CGS YA PEV+ G YD
Sbjct: 151 SICHRDLKPENLLLD-EKNNIRIADFGMASLQVG-DSLLETSCGSPHYACPEVIKGEKYD 208
Query: 190 PKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQ 249
++ D+WS GV+L+ ++ G +PFDD ++ L + KRGV + + C++L+ +++
Sbjct: 209 GRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHF-IPPDCQSLLRGMIE 267
Query: 250 FSPSARPSAGQVARNCWLRAG 270
P R S Q+ ++ W G
Sbjct: 268 VEPEKRLSLEQIQKHPWYLGG 288
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 150 bits (380), Expect = 9e-37
Identities = 88/261 (33%), Positives = 146/261 (55%), Gaps = 8/261 (3%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y+L +T+G+G VK+ VAIK+V+R + + K + RE++IL+ + HPH
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMK-VEREIAILKLIEHPH 77
Query: 72 IVHVFEFIEVCNGK-LYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDH 129
++ + + E N K LY+V+E + +L + + GR+ +AR F QI A+ + H H
Sbjct: 78 VLKLHDVYE--NKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSH 135
Query: 130 HLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYD 189
+ HRDLK EN+LL ++ +++ DFG G L T CGS YA PEV+ G YD
Sbjct: 136 SICHRDLKPENLLLD-EKNNIRIADFGMASLQVG-DSLLETSCGSPHYACPEVIRGEKYD 193
Query: 190 PKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQ 249
+K DVWS GV+L+ ++ G +PFDD ++ L + KRGV + + C++L+ +++
Sbjct: 194 GRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHF-IPPDCQSLLRGMIE 252
Query: 250 FSPSARPSAGQVARNCWLRAG 270
+ R + + ++ W G
Sbjct: 253 VDAARRLTLEHIQKHIWYIGG 273
>gi|156105707 SNF related kinase [Homo sapiens]
Length = 765
Score = 149 bits (377), Expect = 2e-36
Identities = 95/265 (35%), Positives = 146/265 (55%), Gaps = 12/265 (4%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y L +T+G G ++ VK+A VA+KV+D+ + L +E+ ++ V+HP+
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQHPN 74
Query: 72 IVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQRNGR-IPGVQARDLFAQIAGAVRYLHDH 129
IV ++E I+ KLY+++E D+ + ++ + A+ FAQI A+ Y H
Sbjct: 75 IVRLYEVIDT-QTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 130 HLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYD 189
H+VHRDLK ENV+ + VKLTDFGF + L TT CGS AY++PE+LLG YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKL-TTSCGSLAYSAPEILLGDEYD 192
Query: 190 PKKYDVWSMGVVLYVMVTGCMPF---DDSDIAGLPRRQKRGVLYPEGLELSERCKALIAE 246
D+WS+GV+L+++V G PF +DS+ + K Y +S+ CK LI
Sbjct: 193 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCK----YTVPSHVSKECKDLITR 248
Query: 247 LLQFSPSARPSAGQVARNCWLRAGD 271
+LQ P R S ++ + WL+ D
Sbjct: 249 MLQRDPKRRASLEEIENHPWLQGVD 273
>gi|156105705 SNF related kinase [Homo sapiens]
Length = 765
Score = 149 bits (377), Expect = 2e-36
Identities = 95/265 (35%), Positives = 146/265 (55%), Gaps = 12/265 (4%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y L +T+G G ++ VK+A VA+KV+D+ + L +E+ ++ V+HP+
Sbjct: 16 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDT-LATGHLFQEVRCMKLVQHPN 74
Query: 72 IVHVFEFIEVCNGKLYIVMEAA-ATDLLQAVQRNGR-IPGVQARDLFAQIAGAVRYLHDH 129
IV ++E I+ KLY+++E D+ + ++ + A+ FAQI A+ Y H
Sbjct: 75 IVRLYEVIDT-QTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKL 133
Query: 130 HLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYD 189
H+VHRDLK ENV+ + VKLTDFGF + L TT CGS AY++PE+LLG YD
Sbjct: 134 HVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKL-TTSCGSLAYSAPEILLGDEYD 192
Query: 190 PKKYDVWSMGVVLYVMVTGCMPF---DDSDIAGLPRRQKRGVLYPEGLELSERCKALIAE 246
D+WS+GV+L+++V G PF +DS+ + K Y +S+ CK LI
Sbjct: 193 APAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCK----YTVPSHVSKECKDLITR 248
Query: 247 LLQFSPSARPSAGQVARNCWLRAGD 271
+LQ P R S ++ + WL+ D
Sbjct: 249 MLQRDPKRRASLEEIENHPWLQGVD 273
>gi|94557301 protein kinase, AMP-activated, alpha 1 catalytic
subunit isoform 1 [Homo sapiens]
Length = 559
Score = 147 bits (370), Expect = 1e-35
Identities = 88/258 (34%), Positives = 138/258 (53%), Gaps = 5/258 (1%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPP-DFVNKFLPRELSILRGVRHP 70
Y LG T+G G++ KVKV + VA+K+++R++ D V K + RE+ L+ RHP
Sbjct: 27 YILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGK-IRREIQNLKLFRHP 85
Query: 71 HIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
HI+ +++ I + ++ + +L + +NGR+ ++R LF QI V Y H H
Sbjct: 86 HIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHM 145
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
+VHRDLK ENVLL K+ DFG L T+ CGS YA+PEV+ G Y
Sbjct: 146 VVHRDLKPENVLLDA-HMNAKIADFGLSNMMSDGEFLRTS-CGSPNYAAPEVISGRLYAG 203
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
+ D+WS GV+LY ++ G +PFDD + L ++ G+ Y L+ +L+ +LQ
Sbjct: 204 PEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY-LNPSVISLLKHMLQV 262
Query: 251 SPSARPSAGQVARNCWLR 268
P R + + + W +
Sbjct: 263 DPMKRATIKDIREHEWFK 280
>gi|23503303 serine/threonine-protein kinase NIM1 [Homo sapiens]
Length = 436
Score = 146 bits (369), Expect = 2e-35
Identities = 86/258 (33%), Positives = 145/258 (56%), Gaps = 6/258 (2%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPH 71
Y++ IG G++S+VK+ K VAIK++D+ + + L RE+S + + HP+
Sbjct: 74 YRIRGEIGSGNFSQVKLGIHSLTKEKVAIKILDKTKLDQK-TQRLLSREISSMEKLHHPN 132
Query: 72 IVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHH 130
I+ ++E +E + KL++VME A +L + G++ +++ +F+QI AV+++H++
Sbjct: 133 IIRLYEVVETLS-KLHLVMEYAGGGELFGKISTEGKLSEPESKLIFSQIVSAVKHMHENQ 191
Query: 131 LVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDP 190
++HRDLK ENV + VK+ DFGF + ++ T+CGS YA+PE+ Y
Sbjct: 192 IIHRDLKAENVFYT-SNTCVKVGDFGFSTVSK-KGEMLNTFCGSPPYAAPELFRDEHYIG 249
Query: 191 KKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQF 250
D+W++GV+LY MVTG MPF +A L + G Y +SE C LI +LQ
Sbjct: 250 IYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGT-YSVPPHVSEPCHRLIRGVLQQ 308
Query: 251 SPSARPSAGQVARNCWLR 268
P+ R + + W++
Sbjct: 309 IPTERYGIDCIMNDEWMQ 326
>gi|7661974 maternal embryonic leucine zipper kinase [Homo sapiens]
Length = 651
Score = 146 bits (368), Expect = 2e-35
Identities = 93/261 (35%), Positives = 140/261 (53%), Gaps = 13/261 (4%)
Query: 12 YKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPR---ELSILRGVR 68
Y+L TIG G ++KVK+A VAIK++D+ D LPR E+ L+ +R
Sbjct: 11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSD-----LPRIKTEIEALKNLR 65
Query: 69 HPHIVHVFEFIEVCNGKLYIVME-AAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLH 127
H HI ++ +E N K+++V+E +L + R+ + R +F QI AV Y+H
Sbjct: 66 HQHICQLYHVLETAN-KIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVH 124
Query: 128 DHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLST-TYCGSAAYASPEVLLGI 186
HRDLK EN+L + ++KL DFG + G D T CGS AYA+PE++ G
Sbjct: 125 SQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGK 183
Query: 187 PYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAE 246
Y + DVWSMG++LYV++ G +PFDD ++ L ++ RG Y LS L+ +
Sbjct: 184 SYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRG-KYDVPKWLSPSSILLLQQ 242
Query: 247 LLQFSPSARPSAGQVARNCWL 267
+LQ P R S + + W+
Sbjct: 243 MLQVDPKKRISMKNLLNHPWI 263
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.424
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,474,059
Number of Sequences: 37866
Number of extensions: 452841
Number of successful extensions: 3012
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 624
Number of HSP's successfully gapped in prelim test: 171
Number of HSP's that attempted gapping in prelim test: 889
Number of HSP's gapped (non-prelim): 900
length of query: 273
length of database: 18,247,518
effective HSP length: 101
effective length of query: 172
effective length of database: 14,423,052
effective search space: 2480764944
effective search space used: 2480764944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.