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Search of human proteins with 13994242
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
(665 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 1328 0.0
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ... 1216 0.0
gi|11321634 CD2-associated protein [Homo sapiens] 395 e-110
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 114 4e-25
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 114 4e-25
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 111 2e-24
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 105 2e-22
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 105 2e-22
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 105 2e-22
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 97 5e-20
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 97 5e-20
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 97 5e-20
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 95 2e-19
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 95 2e-19
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 95 2e-19
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 95 2e-19
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 93 9e-19
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 86 1e-16
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 85 2e-16
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 85 2e-16
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 85 2e-16
gi|39930351 dynamin binding protein [Homo sapiens] 85 2e-16
gi|55749544 SH3 multiple domains 1 [Homo sapiens] 84 4e-16
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 83 9e-16
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 83 9e-16
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 83 9e-16
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 83 9e-16
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 83 9e-16
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 83 9e-16
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 83 9e-16
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 1328 bits (3437), Expect = 0.0
Identities = 665/665 (100%), Positives = 665/665 (100%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 121 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG 180
VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTG 180
Query: 181 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 240
SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV
Sbjct: 181 SESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 240
Query: 241 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 300
EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD
Sbjct: 241 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 300
Query: 301 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE 360
CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE
Sbjct: 301 CIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHE 360
Query: 361 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR 420
IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR
Sbjct: 361 IKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPR 420
Query: 421 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT 480
RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT
Sbjct: 421 RPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPT 480
Query: 481 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS 540
TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS
Sbjct: 481 TSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTIS 540
Query: 541 QVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME 600
QVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME
Sbjct: 541 QVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKME 600
Query: 601 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK 660
PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK
Sbjct: 601 PAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKK 660
Query: 661 ALQSK 665
ALQSK
Sbjct: 661 ALQSK 665
>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
sapiens]
Length = 628
Score = 1216 bits (3146), Expect = 0.0
Identities = 611/611 (100%), Positives = 611/611 (100%)
Query: 55 EIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQND 114
EIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQND
Sbjct: 18 EIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQND 77
Query: 115 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 174
DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS
Sbjct: 78 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 137
Query: 175 LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE 234
LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE
Sbjct: 138 LRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE 197
Query: 235 NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIV 294
NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIV
Sbjct: 198 NDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIV 257
Query: 295 TLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGT 354
TLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGT
Sbjct: 258 TLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGT 317
Query: 355 TERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRP 414
TERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRP
Sbjct: 318 TERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRP 377
Query: 415 GALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE 474
GALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE
Sbjct: 378 GALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTE 437
Query: 475 KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTS 534
KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTS
Sbjct: 438 KLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTS 497
Query: 535 KTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTE 594
KTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTE
Sbjct: 498 KTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTE 557
Query: 595 GKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQME 654
GKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQME
Sbjct: 558 GKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQME 617
Query: 655 VNDIKKALQSK 665
VNDIKKALQSK
Sbjct: 618 VNDIKKALQSK 628
Score = 79.7 bits (195), Expect = 8e-15
Identities = 37/70 (52%), Positives = 50/70 (71%), Gaps = 2/70 (2%)
Query: 6 VEFDYQAQHDDELTISVGEIITNIRKE--DGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
V F Y+AQ+DDELTI G+I+T I K+ D GWWEG++NGRRG+FPDNFV+ + + +K+
Sbjct: 237 VIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKE 296
Query: 64 PLTNKAPEKP 73
K P P
Sbjct: 297 GNRPKKPPPP 306
Score = 65.1 bits (157), Expect = 2e-10
Identities = 26/54 (48%), Positives = 38/54 (70%)
Query: 6 VEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKE 59
V F Y Q+DDEL + VG+II + + + GWWEG +NG+ G+FP NF++E+ E
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGE 121
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 395 bits (1014), Expect = e-110
Identities = 263/704 (37%), Positives = 375/704 (53%), Gaps = 106/704 (15%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRK-EDGGWWEGQINGRRGLFPDNFVREIKKE 59
MV+ IVE+DY A HDDELTI VGEII N++K ++ GW EG++NGRRG+FPDNFV+EIK+E
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRE 60
Query: 60 --MKKDPLTNKAPEK----------PLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAF 107
K D L K + +P+G +T N + + ++R+C+V F
Sbjct: 61 TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQT---KNIKKKTKKRQCKVLF 117
Query: 108 SYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESD-ELGISQ 166
Y+PQN+DELELKVGDII++ EVEEGWW G LN K G+FPSNF+KEL D E +Q
Sbjct: 118 EYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQ 177
Query: 167 DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 226
D+ S++ L T G+ S T A+G+V QPKK++G+GFGDIFK+ +KL
Sbjct: 178 DD--SETVLAGPTSPIPSLGNVSET----ASGSVT----QPKKIRGIGFGDIFKEGSVKL 227
Query: 227 RPRSIEVENDFLPVEK-TIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDE 285
R R+ E + EK I + L T + + +KT+ + + K+K+YC+ +F YE N+DE
Sbjct: 228 RTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDE 287
Query: 286 LTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPS- 344
LT KEG+I+ LI+K+ + GWW GELNG+ GVFPDNF + + +K+ +PKKPPPP+
Sbjct: 288 LTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQI-NELDKDFPKPKKPPPPAK 346
Query: 345 APVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPR 404
AP K E+K+ K P +EK E++P KP+ P +PPKKP
Sbjct: 347 APAPKPELIAAEKKYFSLK---------PEEKDEKSTLEQKP----SKPAAPQVPPKKPT 393
Query: 405 PP--KTNSLSRPGALPPRRPERPV----------------------GPLTHTRGDSPKID 440
PP +N L G + P+RPE+PV P++ + DS ++
Sbjct: 394 PPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSKFETEPVSKLKLDSEQLP 453
Query: 441 LAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSS 500
L S+ D S + D+ FD + SS E L H T +RPK GRR P +
Sbjct: 454 LRPKSVD--FDSLTVRTSKETDVVNFDDIASS-ENLLHLTANRPKMPGRRLPGR------ 504
Query: 501 LSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGG 560
SP E+ + L A+ K S+ PKP
Sbjct: 505 -----FNGGHSPTHSPEKILKLPKEEDSANLKPSEL-------KKDTCYSPKPSVYL--- 549
Query: 561 GGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELR 620
+ PS S + TA L E K K+E + +++ELR Q+ EL
Sbjct: 550 --------STPSSASKANTTA-------FLTPLEIKAKVETDDVKKNSLDELRAQIIELL 594
Query: 621 SIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQS 664
I+E +K +E+++L +L+EEK +R L+ME+ +KKA+ S
Sbjct: 595 CIVEALKKDHGKELEKLRKDLEEEKTMRSNLEMEIEKLKKAVLS 638
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 114 bits (284), Expect = 4e-25
Identities = 87/332 (26%), Positives = 153/332 (46%), Gaps = 44/332 (13%)
Query: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR----EIK 57
++A + ++A+ D+ L + ++IT + ++D WW G++ G++G FP ++V+ I+
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIR 974
Query: 58 KEMKKDPLTNKAPEKPLHEV--PSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDD 115
K D ++++P L V P+ ++S E + ++Y
Sbjct: 975 KSTSMDSGSSESPAS-LKRVASPAAKPVVSGEEFI--------------AMYTYESSEQG 1019
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSL 175
+L + GD+I +V + + WW G + K G+FPSN+++ E K +
Sbjct: 1020 DLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
Query: 176 RETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVEN 235
+ S + G T + G I+ K G G+ L+ R + +
Sbjct: 1079 AQVIASYTATGPEQLTLAPG-----QLILIRKKNPGGWWEGE--------LQARGKKRQI 1125
Query: 236 DFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDDELTIKEGDI 293
+ P KL + T + TE T C+VI + Y AQNDDEL +G I
Sbjct: 1126 GWFPANYV---KL-LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQI 1181
Query: 294 VTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 325
+ ++NK+ D WW+GE+NG+ G+FP N+VKL
Sbjct: 1182 INVLNKE--DPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 80.1 bits (196), Expect = 6e-15
Identities = 95/432 (21%), Positives = 159/432 (36%), Gaps = 121/432 (28%)
Query: 8 FDYQAQHDDELTISVGEIIT-------NIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
+ ++++ DE+TI G+I+ + + GW G++ G+ G FP N+ +I +
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808
Query: 61 KKDPL-----------------------------------------------TNKAPE-- 71
P+ TN+ PE
Sbjct: 809 VPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETD 868
Query: 72 -------KPLHEVPSGNSLLSSETILRTNKRGER-----------RRRRCQVAFSYLPQN 113
+P VPS L G + Q + + +
Sbjct: 869 NWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKK 928
Query: 114 DDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS 173
D+ L D+I V+ E ++ WW G + G+ G FP +++K +SG
Sbjct: 929 DNHLNFNKNDVITVL-EQQDMWWFGEVQGQKGWFPKSYVKLISGP--------------- 972
Query: 174 SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEV 233
+R++T DS S++S + VA+ A +P V G F ++ + + + +
Sbjct: 973 -IRKSTSM-----DSGSSESPASLKRVASPAAKPV-VSGEEFIAMYTYESSEQGDLTFQQ 1025
Query: 234 ENDFLPVEK-------TIGKKLPATTATPDSSKTEMDSRTKSK--------DYCKVIFPY 278
+ L +K T+G K + K S T K + +VI Y
Sbjct: 1026 GDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASY 1085
Query: 279 EAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR-----GVFPDNFVKLLPPDFEKE 333
A ++LT+ G ++ + K+ GWWEGEL R G FP N+VKLL P K
Sbjct: 1086 TATGPEQLTLAPGQLILIRKKN--PGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSK- 1142
Query: 334 GNRPKKPPPPSA 345
P +PP +A
Sbjct: 1143 -ITPTEPPKSTA 1153
Score = 54.3 bits (129), Expect = 4e-07
Identities = 47/167 (28%), Positives = 71/167 (42%), Gaps = 30/167 (17%)
Query: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCID------VGWWEGELNGRRGVFPDNFVK 324
Y + ++P+E+++ DE+TI+ GDIV ++ + +D GW GEL G+ G FP N+ +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIV-MVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
Query: 325 LLPPDFEKEGNRPKKP--PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNR------- 375
+P E E P KP SAP K T + P PN
Sbjct: 803 KIP---ENEVPAPVKPVTDSTSAPAPKLALRETPAP---LAVTSSEPSTTPNNWADFSST 856
Query: 376 --TEEKERPERE------PKLDLQKPSVPAIPPKKPRPPKTNSLSRP 414
T E+PE + + L PS + + P T + S P
Sbjct: 857 WPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 114 bits (284), Expect = 4e-25
Identities = 87/332 (26%), Positives = 153/332 (46%), Gaps = 44/332 (13%)
Query: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR----EIK 57
++A + ++A+ D+ L + ++IT + ++D WW G++ G++G FP ++V+ I+
Sbjct: 916 LQAQALYPWRAKKDNHLNFNKNDVITVLEQQDM-WWFGEVQGQKGWFPKSYVKLISGPIR 974
Query: 58 KEMKKDPLTNKAPEKPLHEV--PSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDD 115
K D ++++P L V P+ ++S E + ++Y
Sbjct: 975 KSTSMDSGSSESPAS-LKRVASPAAKPVVSGEEFI--------------AMYTYESSEQG 1019
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSL 175
+L + GD+I +V + + WW G + K G+FPSN+++ E K +
Sbjct: 1020 DLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
Query: 176 RETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVEN 235
+ S + G T + G I+ K G G+ L+ R + +
Sbjct: 1079 AQVIASYTATGPEQLTLAPG-----QLILIRKKNPGGWWEGE--------LQARGKKRQI 1125
Query: 236 DFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDDELTIKEGDI 293
+ P KL + T + TE T C+VI + Y AQNDDEL +G I
Sbjct: 1126 GWFPANYV---KL-LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQI 1181
Query: 294 VTLINKDCIDVGWWEGELNGRRGVFPDNFVKL 325
+ ++NK+ D WW+GE+NG+ G+FP N+VKL
Sbjct: 1182 INVLNKE--DPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 80.1 bits (196), Expect = 6e-15
Identities = 95/432 (21%), Positives = 159/432 (36%), Gaps = 121/432 (28%)
Query: 8 FDYQAQHDDELTISVGEIIT-------NIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
+ ++++ DE+TI G+I+ + + GW G++ G+ G FP N+ +I +
Sbjct: 749 YPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENE 808
Query: 61 KKDPL-----------------------------------------------TNKAPE-- 71
P+ TN+ PE
Sbjct: 809 VPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEKPETD 868
Query: 72 -------KPLHEVPSGNSLLSSETILRTNKRGER-----------RRRRCQVAFSYLPQN 113
+P VPS L G + Q + + +
Sbjct: 869 NWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKK 928
Query: 114 DDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKS 173
D+ L D+I V+ E ++ WW G + G+ G FP +++K +SG
Sbjct: 929 DNHLNFNKNDVITVL-EQQDMWWFGEVQGQKGWFPKSYVKLISGP--------------- 972
Query: 174 SLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEV 233
+R++T DS S++S + VA+ A +P V G F ++ + + + +
Sbjct: 973 -IRKSTSM-----DSGSSESPASLKRVASPAAKPV-VSGEEFIAMYTYESSEQGDLTFQQ 1025
Query: 234 ENDFLPVEK-------TIGKKLPATTATPDSSKTEMDSRTKSK--------DYCKVIFPY 278
+ L +K T+G K + K S T K + +VI Y
Sbjct: 1026 GDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEIAQVIASY 1085
Query: 279 EAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR-----GVFPDNFVKLLPPDFEKE 333
A ++LT+ G ++ + K+ GWWEGEL R G FP N+VKLL P K
Sbjct: 1086 TATGPEQLTLAPGQLILIRKKN--PGGWWEGELQARGKKRQIGWFPANYVKLLSPGTSK- 1142
Query: 334 GNRPKKPPPPSA 345
P +PP +A
Sbjct: 1143 -ITPTEPPKSTA 1153
Score = 54.3 bits (129), Expect = 4e-07
Identities = 47/167 (28%), Positives = 71/167 (42%), Gaps = 30/167 (17%)
Query: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCID------VGWWEGELNGRRGVFPDNFVK 324
Y + ++P+E+++ DE+TI+ GDIV ++ + +D GW GEL G+ G FP N+ +
Sbjct: 744 YYRALYPFESRSHDEITIQPGDIV-MVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE 802
Query: 325 LLPPDFEKEGNRPKKP--PPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNR------- 375
+P E E P KP SAP K T + P PN
Sbjct: 803 KIP---ENEVPAPVKPVTDSTSAPAPKLALRETPAP---LAVTSSEPSTTPNNWADFSST 856
Query: 376 --TEEKERPERE------PKLDLQKPSVPAIPPKKPRPPKTNSLSRP 414
T E+PE + + L PS + + P T + S P
Sbjct: 857 WPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSP 903
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 111 bits (277), Expect = 2e-24
Identities = 178/791 (22%), Positives = 281/791 (35%), Gaps = 192/791 (24%)
Query: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDG-GWWEGQINGRRGLFPDNFVREIKKEM 60
+E +V Y+AQ +DEL+++ G+++ +R GW G+ GR GLFP+ V+EI + +
Sbjct: 1 MEVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETL 60
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
+ + P+ + R +R C+V FSY P+ DEL+L+
Sbjct: 61 RGSGEARRPRCARRRGHPA---------------KHPRPQRWCKVNFSYSPEQADELKLQ 105
Query: 121 VGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELG----------------- 163
G+I+E++ E+E+GWW G NG+ G FPSNF++ L LG
Sbjct: 106 AGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRPPKL 165
Query: 164 -----ISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGD- 217
S + L S E D + + G V + + KG G+
Sbjct: 166 SSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGEC 225
Query: 218 -----IFKDK------PI-KLRPRSIEVENDFLPVEK----------TIGKKLPATTATP 255
+F D PI KL PR + V + P+++ KKL T P
Sbjct: 226 QGRRGVFPDNFVLPPPPIKKLVPRKV-VSRESAPIKEPKKLMPKTSLPTVKKLATATTGP 284
Query: 256 DSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELN--- 312
+KT SRT S+D K L ++D G ++ +
Sbjct: 285 SKAKT---SRTPSRDSQK----------------------LTSRDSGPNGGFQSGGSYHP 319
Query: 313 GRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML 372
GR+ + E+E + P K P + T ER + P +
Sbjct: 320 GRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPA 379
Query: 373 PNRTEEKERPEREPKLDL-QKPSVPA--------IPPKKPRPPKTNSLSRPGALP----- 418
P++ P E L L K S+P P K P P K + ++P
Sbjct: 380 PDKV-----PSPEKTLTLGDKASIPGNSTSGKIPAPDKVPTPEKMVTPEDKASIPENSII 434
Query: 419 ---------PRRPERPVGPLTHTRGDSPKIDLA-----------GSSLSGILDKDLSDRS 458
P PER ++P +D +L +L +LS+
Sbjct: 435 PEETLTVDKPSTPERVFSVEESPALEAPPMDKVPNPKMAPLGDEAPTLEKVLTPELSEEE 494
Query: 459 ----NDIDLEGFDS---------VVSSTEKLSHPTTSRPKATGRRPPS------------ 493
+DI F S V+ + S P+A +PPS
Sbjct: 495 VSTRDDIQFHHFSSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTL 554
Query: 494 --------QSLTSSSLSSPDIFDSPSPEED----------------KEEHISLAHRGVDA 529
Q+ S +S + P P E+ +EE R +
Sbjct: 555 VRGDSSPRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLRE 614
Query: 530 SKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPS 589
+ V + K LPPK AP P + + T + P
Sbjct: 615 EVLPKEGVASKEEVTLKEELPPKEEV--------APKEEVPPIERAFAQKTRPIKP-PPD 665
Query: 590 LFGTEGKPKMEPAASSQ-----AAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEE 644
T P + P ++ V LR +V LR +E M+ Q +R++ + EL E
Sbjct: 666 SQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSE 725
Query: 645 KKIRLRLQMEV 655
K+ R RL+++V
Sbjct: 726 KEQRRRLEVQV 736
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 105 bits (261), Expect = 2e-22
Identities = 80/327 (24%), Positives = 140/327 (42%), Gaps = 43/327 (13%)
Query: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
A+V D+ A+ D+L ++ GEI+ + K D W+ G + G+FP N+V
Sbjct: 441 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV---------- 490
Query: 64 PLTNKAPEKPLHEVPSGNS----LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELEL 119
K + ++P G + +SS + + RC F Y+ + DEL
Sbjct: 491 --------KVIIDIPEGGNGKRECVSSHCV---------KGSRCVARFEYIGEQKDELSF 533
Query: 120 KVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETT 179
G+II + V E W G + G+TG+FP NF++ + ++ + +E +
Sbjct: 534 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDS 593
Query: 180 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 239
GS S + E + A + +G + + R R + E F
Sbjct: 594 GSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPA 653
Query: 240 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 299
V P +K+ + K + K ++ + +N+DEL+ K GDI+T +
Sbjct: 654 V---------FVRPCPAEAKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDIITEL-- 701
Query: 300 DCIDVGWWEGELNGRRGVFPDNFVKLL 326
+ +D W GEL G+ G+FP N+++ L
Sbjct: 702 ESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/227 (22%), Positives = 99/227 (43%), Gaps = 29/227 (12%)
Query: 115 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 174
D+L L G+I+ ++ +++ W+ G + G+FP+N++K + + E G + E +S
Sbjct: 453 DDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII-DIPEGGNGKRECVSSHC 511
Query: 175 LR--------ETTGSESDGGDSSSTK----SEGANGTVATAAIQPKKVKGVGFGDIFKDK 222
++ E G + D S + E N A ++ + G + +
Sbjct: 512 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR----TGIFPLNFVE 567
Query: 223 PIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQN 282
P++ P S + K+P T DS + + ++C+ + + A+
Sbjct: 568 PVEDYPTS---------GANVLSTKVPLKTKKEDSGSNSQVNSLPA-EWCEALHSFTAET 617
Query: 283 DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD 329
D+L+ K GD + ++ + +D W G L R G+FP FV+ P +
Sbjct: 618 SDDLSFKRGDRIQILER--LDSDWCRGRLQDREGIFPAVFVRPCPAE 662
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
C F Y + DEL+ EG+I+ L K+ ++ W GE+ GR G+FP NFV+ + D+
Sbjct: 517 CVARFEYIGEQKDELSFSEGEIIIL--KEYVNEEWARGEVRGRTGIFPLNFVEPV-EDYP 573
Query: 332 KEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEE 378
G P K+ +G+ ++ +P E E L + T E
Sbjct: 574 TSGANVLSTKVP-LKTKKEDSGSNS---QVNSLPAEWCEALHSFTAE 616
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
P ++ +DS + V+ + A+ D+L + G+IV L+ K ID W+ G +
Sbjct: 427 PSHAQKPVDS---GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEK--IDTDWYRGNCRNQ 481
Query: 315 RGVFPDNFVKLLPPDFEKEGN 335
G+FP N+VK++ D + GN
Sbjct: 482 IGIFPANYVKVI-IDIPEGGN 501
Score = 30.8 bits (68), Expect = 4.2
Identities = 41/165 (24%), Positives = 62/165 (37%), Gaps = 24/165 (14%)
Query: 341 PPPSAPVIKQGAGTTE--RKHEIKKIPPERPEMLP------NRTEEKERPEREPKLDLQK 392
P PS + ++ G+ HE + PP P P + + ER L+
Sbjct: 214 PTPSGNLAEESVGSEMVLGLHEDPQSPPPLPAEKPIGNTFSTVSGKLSNVERTRNLESNH 273
Query: 393 PSVPA----IPPKKPRPP---KTNSLSRPGA-LPPRRPERPVGPLTHTRGDSPKIDLAGS 444
P +PP+ P P KT +P +PP RP P L+ TR + K+ S
Sbjct: 274 PGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP--KLSATRRSNKKLPFNRS 331
Query: 445 SLSGILDKDLSDRSNDID------LEGFDSVVSSTEKLSHPTTSR 483
S L K S+ + + + D V+ K HP S+
Sbjct: 332 SSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 376
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 105 bits (261), Expect = 2e-22
Identities = 80/327 (24%), Positives = 140/327 (42%), Gaps = 43/327 (13%)
Query: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
A+V D+ A+ D+L ++ GEI+ + K D W+ G + G+FP N+V
Sbjct: 477 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV---------- 526
Query: 64 PLTNKAPEKPLHEVPSGNS----LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELEL 119
K + ++P G + +SS + + RC F Y+ + DEL
Sbjct: 527 --------KVIIDIPEGGNGKRECVSSHCV---------KGSRCVARFEYIGEQKDELSF 569
Query: 120 KVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETT 179
G+II + V E W G + G+TG+FP NF++ + ++ + +E +
Sbjct: 570 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDS 629
Query: 180 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 239
GS S + E + A + +G + + R R + E F
Sbjct: 630 GSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPA 689
Query: 240 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 299
V P +K+ + K + K ++ + +N+DEL+ K GDI+T +
Sbjct: 690 V---------FVRPCPAEAKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDIITEL-- 737
Query: 300 DCIDVGWWEGELNGRRGVFPDNFVKLL 326
+ +D W GEL G+ G+FP N+++ L
Sbjct: 738 ESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/227 (22%), Positives = 99/227 (43%), Gaps = 29/227 (12%)
Query: 115 DELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSS 174
D+L L G+I+ ++ +++ W+ G + G+FP+N++K + + E G + E +S
Sbjct: 489 DDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII-DIPEGGNGKRECVSSHC 547
Query: 175 LR--------ETTGSESDGGDSSSTK----SEGANGTVATAAIQPKKVKGVGFGDIFKDK 222
++ E G + D S + E N A ++ + G + +
Sbjct: 548 VKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR----TGIFPLNFVE 603
Query: 223 PIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQN 282
P++ P S + K+P T DS + + ++C+ + + A+
Sbjct: 604 PVEDYPTS---------GANVLSTKVPLKTKKEDSGSNSQVNSLPA-EWCEALHSFTAET 653
Query: 283 DDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD 329
D+L+ K GD + ++ + +D W G L R G+FP FV+ P +
Sbjct: 654 SDDLSFKRGDRIQILER--LDSDWCRGRLQDREGIFPAVFVRPCPAE 698
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
C F Y + DEL+ EG+I+ L K+ ++ W GE+ GR G+FP NFV+ + D+
Sbjct: 553 CVARFEYIGEQKDELSFSEGEIIIL--KEYVNEEWARGEVRGRTGIFPLNFVEPV-EDYP 609
Query: 332 KEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEE 378
G P K+ +G+ ++ +P E E L + T E
Sbjct: 610 TSGANVLSTKVP-LKTKKEDSGSNS---QVNSLPAEWCEALHSFTAE 652
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
P ++ +DS + V+ + A+ D+L + G+IV L+ K ID W+ G +
Sbjct: 463 PSHAQKPVDS---GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEK--IDTDWYRGNCRNQ 517
Query: 315 RGVFPDNFVKLLPPDFEKEGN 335
G+FP N+VK++ D + GN
Sbjct: 518 IGIFPANYVKVI-IDIPEGGN 537
Score = 34.3 bits (77), Expect = 0.38
Identities = 47/179 (26%), Positives = 67/179 (37%), Gaps = 23/179 (12%)
Query: 326 LPPDFEKEGNRPKKPPPPSAP-VIKQGAGTTERKHEIKKIPPERPEMLP------NRTEE 378
LP E R +P P P VI+ A + HE + PP P P + +
Sbjct: 236 LPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGK 295
Query: 379 KERPEREPKLDLQKPSVPA----IPPKKPRPP---KTNSLSRPGA-LPPRRPERPVGPLT 430
ER L+ P +PP+ P P KT +P +PP RP P L+
Sbjct: 296 LSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP--KLS 353
Query: 431 HTRGDSPKIDLAGSSLSGILDKDLSDRSNDID------LEGFDSVVSSTEKLSHPTTSR 483
TR + K+ SS L K S+ + + + D V+ K HP S+
Sbjct: 354 ATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 412
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 105 bits (261), Expect = 2e-22
Identities = 80/327 (24%), Positives = 140/327 (42%), Gaps = 43/327 (13%)
Query: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
A+V D+ A+ D+L ++ GEI+ + K D W+ G + G+FP N+V
Sbjct: 500 AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV---------- 549
Query: 64 PLTNKAPEKPLHEVPSGNS----LLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELEL 119
K + ++P G + +SS + + RC F Y+ + DEL
Sbjct: 550 --------KVIIDIPEGGNGKRECVSSHCV---------KGSRCVARFEYIGEQKDELSF 592
Query: 120 KVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETT 179
G+II + V E W G + G+TG+FP NF++ + ++ + +E +
Sbjct: 593 SEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDS 652
Query: 180 GSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLP 239
GS S + E + A + +G + + R R + E F
Sbjct: 653 GSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPA 712
Query: 240 VEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINK 299
V P +K+ + K + K ++ + +N+DEL+ K GDI+T +
Sbjct: 713 V---------FVRPCPAEAKSMLAIVPKGRK-AKALYDFRGENEDELSFKAGDIITEL-- 760
Query: 300 DCIDVGWWEGELNGRRGVFPDNFVKLL 326
+ +D W GEL G+ G+FP N+++ L
Sbjct: 761 ESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 67.0 bits (162), Expect = 5e-11
Identities = 68/340 (20%), Positives = 137/340 (40%), Gaps = 54/340 (15%)
Query: 5 IVEFDYQAQHDDELTISVGEIITNIRKEDGGWWE---GQINGRRGLFPDNFVREIKKEMK 61
I D +Q+ EL+ G+++ +++ + + E G+ GR L + + + ++
Sbjct: 421 IANEDIVSQNPGELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLR 480
Query: 62 KDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
P +KP V SG V + + D+L L
Sbjct: 481 SRPNDPSHAQKP---VDSGAP-------------------HAVVLHDFPAEQVDDLNLTS 518
Query: 122 GDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLR----- 176
G+I+ ++ +++ W+ G + G+FP+N++K + + E G + E +S ++
Sbjct: 519 GEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII-DIPEGGNGKRECVSSHCVKGSRCV 577
Query: 177 ---ETTGSESDGGDSSSTK----SEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPR 229
E G + D S + E N A ++ + G + +P++ P
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR----TGIFPLNFVEPVEDYPT 633
Query: 230 SIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIK 289
S + K+P T DS + + ++C+ + + A+ D+L+ K
Sbjct: 634 S---------GANVLSTKVPLKTKKEDSGSNSQVNSLPA-EWCEALHSFTAETSDDLSFK 683
Query: 290 EGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPD 329
GD + ++ + +D W G L R G+FP FV+ P +
Sbjct: 684 RGDRIQILER--LDSDWCRGRLQDREGIFPAVFVRPCPAE 721
Score = 48.1 bits (113), Expect = 3e-05
Identities = 33/107 (30%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFE 331
C F Y + DEL+ EG+I+ L K+ ++ W GE+ GR G+FP NFV+ + D+
Sbjct: 576 CVARFEYIGEQKDELSFSEGEIIIL--KEYVNEEWARGEVRGRTGIFPLNFVEPV-EDYP 632
Query: 332 KEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEE 378
G P K+ +G+ ++ +P E E L + T E
Sbjct: 633 TSGANVLSTKVP-LKTKKEDSGSNS---QVNSLPAEWCEALHSFTAE 675
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/81 (30%), Positives = 43/81 (53%), Gaps = 6/81 (7%)
Query: 255 PDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR 314
P ++ +DS + V+ + A+ D+L + G+IV L+ K ID W+ G +
Sbjct: 486 PSHAQKPVDS---GAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEK--IDTDWYRGNCRNQ 540
Query: 315 RGVFPDNFVKLLPPDFEKEGN 335
G+FP N+VK++ D + GN
Sbjct: 541 IGIFPANYVKVI-IDIPEGGN 560
Score = 34.3 bits (77), Expect = 0.38
Identities = 47/179 (26%), Positives = 67/179 (37%), Gaps = 23/179 (12%)
Query: 326 LPPDFEKEGNRPKKPPPPSAP-VIKQGAGTTERKHEIKKIPPERPEMLP------NRTEE 378
LP E R +P P P VI+ A + HE + PP P P + +
Sbjct: 236 LPAKTEPIKERAVQPAPTRKPTVIRIPAKPGKCLHEDPQSPPPLPAEKPIGNTFSTVSGK 295
Query: 379 KERPEREPKLDLQKPSVPA----IPPKKPRPP---KTNSLSRPGA-LPPRRPERPVGPLT 430
ER L+ P +PP+ P P KT +P +PP RP P L+
Sbjct: 296 LSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPP--KLS 353
Query: 431 HTRGDSPKIDLAGSSLSGILDKDLSDRSNDID------LEGFDSVVSSTEKLSHPTTSR 483
TR + K+ SS L K S+ + + + D V+ K HP S+
Sbjct: 354 ATRRSNKKLPFNRSSSDMDLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLYSK 412
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 97.1 bits (240), Expect = 5e-20
Identities = 82/327 (25%), Positives = 140/327 (42%), Gaps = 63/327 (19%)
Query: 10 YQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR-----EIKKEMKKD- 63
+ A+ D+ L S +IIT + +++ WW G+++G RG FP ++V+ E+K+E +
Sbjct: 882 WTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEAL 940
Query: 64 -PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVG 122
NK P + V G ++ + Y +L G
Sbjct: 941 YAAVNKKPTSAAYSV--GEEYIA--------------------LYPYSSVEPGDLTFTEG 978
Query: 123 DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSE 182
+ I +V + + WW G + ++G+FPSN++K ES K + + T +
Sbjct: 979 EEI-LVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAY 1037
Query: 183 SDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE- 241
G + + G I K G G+ L+ R + + + P
Sbjct: 1038 VASGSEQLSLAPGQ-----LILILKKNTSGWWQGE--------LQARGKKRQKGWFPASH 1084
Query: 242 -KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDDELTIKEGDIVTLIN 298
K +G + ATP C+VI + Y A N+DEL+ +G ++ ++N
Sbjct: 1085 VKLLGPS--SERATPAFHPV-----------CQVIAMYDYAANNEDELSFSKGQLINVMN 1131
Query: 299 KDCIDVGWWEGELNGRRGVFPDNFVKL 325
KD D WW+GE+NG G+FP N+VK+
Sbjct: 1132 KD--DPDWWQGEINGVTGLFPSNYVKM 1156
Score = 83.2 bits (204), Expect = 7e-16
Identities = 62/206 (30%), Positives = 94/206 (45%), Gaps = 50/206 (24%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM-- 60
E I + Y + +LT + GE I + ++DG WW G I R G+FP N+V+ +E
Sbjct: 958 EYIALYPYSSVEPGDLTFTEGEEIL-VTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFG 1016
Query: 61 --KKDPLTNKAPE---KPLHEVPSGNSLLSSET-----ILRTNK----------RGERRR 100
K +NK PE V SG+ LS IL+ N RG++R+
Sbjct: 1017 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1076
Query: 101 RR------------------------CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEG 134
+ CQV + Y N+DEL G +I V+ + +
Sbjct: 1077 KGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPD 1136
Query: 135 WWEGVLNGKTGMFPSNFIKELSGESD 160
WW+G +NG TG+FPSN++K ++ +SD
Sbjct: 1137 WWQGEINGVTGLFPSNYVK-MTTDSD 1161
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/296 (23%), Positives = 124/296 (41%), Gaps = 50/296 (16%)
Query: 43 GRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR 102
G+ L+ +N +E ++E +K K EK E + T K E++R
Sbjct: 672 GKENLWKENLRKE-EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDK--DTLKAEEKKRET 728
Query: 103 CQVAFSYLP------QNDDELELKVGDIIEVVGEV--EEGWWEGVLNGKTGMFPSNFIKE 154
V +Y +N DE+ GDII+V + E GW G G G FP N++++
Sbjct: 729 ASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEK 788
Query: 155 LSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKV---K 211
+ +E +S K +L T S S ++ST SE + QP V +
Sbjct: 789 MPSSENEKAVSP-----KKALLPPTVSLS----ATSTSSEPLSSN------QPASVTDYQ 833
Query: 212 GVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDY 271
V F ++ N + + + + +P + ++ K++
Sbjct: 834 NVSFSNL--------------TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQAL 879
Query: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP 327
C + A+ D+ L + DI+T++ + WW GE++G RG FP ++VK++P
Sbjct: 880 CS----WTAKKDNHLNFSKHDIITVLEQQ---ENWWFGEVHGGRGWFPKSYVKIIP 928
Score = 72.4 bits (176), Expect = 1e-12
Identities = 81/377 (21%), Positives = 146/377 (38%), Gaps = 73/377 (19%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDG--GWWEGQINGRRGLFPDNFVREIKKEMKKDPL 65
+ ++A++ DE++ + G+II K G GW G G G FP N+V ++ + +
Sbjct: 739 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 798
Query: 66 TNKA----PEKPLHEVPSGNSLLSSE-------------TILRTNKRGERRRR------- 101
+ K P L + + LSS + L N +++
Sbjct: 799 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 858
Query: 102 ----------------RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTG 145
+ Q S+ + D+ L DII V+ E +E WW G ++G G
Sbjct: 859 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL-EQQENWWFGEVHGGRG 917
Query: 146 MFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAI 205
FP +++K + G E+ + E L + ++ T + G+ A+
Sbjct: 918 WFPKSYVKIIPGS--EVKREEPEALYAAVNKKPTSAAYSVGEEY-------------IAL 962
Query: 206 QPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDS-----SKT 260
P G + + I + + E + I P+ P S +
Sbjct: 963 YPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGI---FPSNYVKPKDQESFGSAS 1019
Query: 261 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR-----R 315
+ + K + +V Y A ++L++ G ++ ++ K+ GWW+GEL R +
Sbjct: 1020 KSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTS--GWWQGELQARGKKRQK 1077
Query: 316 GVFPDNFVKLLPPDFEK 332
G FP + VKLL P E+
Sbjct: 1078 GWFPASHVKLLGPSSER 1094
Score = 55.1 bits (131), Expect = 2e-07
Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 332
+ ++P+EA+N DE++ GDI+ + K + GW G G G FP N+V+ +P +
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 333 EGNRPKKPPPPSAPVIKQGAGTT 355
+ PKK P P + A +T
Sbjct: 796 KAVSPKKALLP--PTVSLSATST 816
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 97.1 bits (240), Expect = 5e-20
Identities = 82/327 (25%), Positives = 140/327 (42%), Gaps = 63/327 (19%)
Query: 10 YQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR-----EIKKEMKKD- 63
+ A+ D+ L S +IIT + +++ WW G+++G RG FP ++V+ E+K+E +
Sbjct: 909 WTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEAL 967
Query: 64 -PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVG 122
NK P + V G ++ + Y +L G
Sbjct: 968 YAAVNKKPTSAAYSV--GEEYIA--------------------LYPYSSVEPGDLTFTEG 1005
Query: 123 DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSE 182
+ I +V + + WW G + ++G+FPSN++K ES K + + T +
Sbjct: 1006 EEI-LVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAY 1064
Query: 183 SDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE- 241
G + + G I K G G+ L+ R + + + P
Sbjct: 1065 VASGSEQLSLAPGQ-----LILILKKNTSGWWQGE--------LQARGKKRQKGWFPASH 1111
Query: 242 -KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDDELTIKEGDIVTLIN 298
K +G + ATP C+VI + Y A N+DEL+ +G ++ ++N
Sbjct: 1112 VKLLGPS--SERATPAFHPV-----------CQVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 299 KDCIDVGWWEGELNGRRGVFPDNFVKL 325
KD D WW+GE+NG G+FP N+VK+
Sbjct: 1159 KD--DPDWWQGEINGVTGLFPSNYVKM 1183
Score = 83.2 bits (204), Expect = 7e-16
Identities = 62/206 (30%), Positives = 94/206 (45%), Gaps = 50/206 (24%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM-- 60
E I + Y + +LT + GE I + ++DG WW G I R G+FP N+V+ +E
Sbjct: 985 EYIALYPYSSVEPGDLTFTEGEEIL-VTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFG 1043
Query: 61 --KKDPLTNKAPE---KPLHEVPSGNSLLSSET-----ILRTNK----------RGERRR 100
K +NK PE V SG+ LS IL+ N RG++R+
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 101 RR------------------------CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEG 134
+ CQV + Y N+DEL G +I V+ + +
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPD 1163
Query: 135 WWEGVLNGKTGMFPSNFIKELSGESD 160
WW+G +NG TG+FPSN++K ++ +SD
Sbjct: 1164 WWQGEINGVTGLFPSNYVK-MTTDSD 1188
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/296 (23%), Positives = 124/296 (41%), Gaps = 50/296 (16%)
Query: 43 GRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR 102
G+ L+ +N +E ++E +K K EK E + T K E++R
Sbjct: 699 GKENLWKENLRKE-EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDK--DTLKAEEKKRET 755
Query: 103 CQVAFSYLP------QNDDELELKVGDIIEVVGEV--EEGWWEGVLNGKTGMFPSNFIKE 154
V +Y +N DE+ GDII+V + E GW G G G FP N++++
Sbjct: 756 ASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEK 815
Query: 155 LSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKV---K 211
+ +E +S K +L T S S ++ST SE + QP V +
Sbjct: 816 MPSSENEKAVSP-----KKALLPPTVSLS----ATSTSSEPLSSN------QPASVTDYQ 860
Query: 212 GVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDY 271
V F ++ N + + + + +P + ++ K++
Sbjct: 861 NVSFSNL--------------TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQAL 906
Query: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP 327
C + A+ D+ L + DI+T++ + WW GE++G RG FP ++VK++P
Sbjct: 907 CS----WTAKKDNHLNFSKHDIITVLEQQ---ENWWFGEVHGGRGWFPKSYVKIIP 955
Score = 72.4 bits (176), Expect = 1e-12
Identities = 81/377 (21%), Positives = 146/377 (38%), Gaps = 73/377 (19%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDG--GWWEGQINGRRGLFPDNFVREIKKEMKKDPL 65
+ ++A++ DE++ + G+II K G GW G G G FP N+V ++ + +
Sbjct: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
Query: 66 TNKA----PEKPLHEVPSGNSLLSSE-------------TILRTNKRGERRRR------- 101
+ K P L + + LSS + L N +++
Sbjct: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
Query: 102 ----------------RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTG 145
+ Q S+ + D+ L DII V+ E +E WW G ++G G
Sbjct: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL-EQQENWWFGEVHGGRG 944
Query: 146 MFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAI 205
FP +++K + G E+ + E L + ++ T + G+ A+
Sbjct: 945 WFPKSYVKIIPGS--EVKREEPEALYAAVNKKPTSAAYSVGEEY-------------IAL 989
Query: 206 QPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDS-----SKT 260
P G + + I + + E + I P+ P S +
Sbjct: 990 YPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGI---FPSNYVKPKDQESFGSAS 1046
Query: 261 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR-----R 315
+ + K + +V Y A ++L++ G ++ ++ K+ GWW+GEL R +
Sbjct: 1047 KSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTS--GWWQGELQARGKKRQK 1104
Query: 316 GVFPDNFVKLLPPDFEK 332
G FP + VKLL P E+
Sbjct: 1105 GWFPASHVKLLGPSSER 1121
Score = 55.1 bits (131), Expect = 2e-07
Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 332
+ ++P+EA+N DE++ GDI+ + K + GW G G G FP N+V+ +P +
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 333 EGNRPKKPPPPSAPVIKQGAGTT 355
+ PKK P P + A +T
Sbjct: 823 KAVSPKKALLP--PTVSLSATST 843
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 97.1 bits (240), Expect = 5e-20
Identities = 82/327 (25%), Positives = 140/327 (42%), Gaps = 63/327 (19%)
Query: 10 YQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR-----EIKKEMKKD- 63
+ A+ D+ L S +IIT + +++ WW G+++G RG FP ++V+ E+K+E +
Sbjct: 909 WTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEAL 967
Query: 64 -PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVG 122
NK P + V G ++ + Y +L G
Sbjct: 968 YAAVNKKPTSAAYSV--GEEYIA--------------------LYPYSSVEPGDLTFTEG 1005
Query: 123 DIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSE 182
+ I +V + + WW G + ++G+FPSN++K ES K + + T +
Sbjct: 1006 EEI-LVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAY 1064
Query: 183 SDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE- 241
G + + G I K G G+ L+ R + + + P
Sbjct: 1065 VASGSEQLSLAPGQ-----LILILKKNTSGWWQGE--------LQARGKKRQKGWFPASH 1111
Query: 242 -KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI--FPYEAQNDDELTIKEGDIVTLIN 298
K +G + ATP C+VI + Y A N+DEL+ +G ++ ++N
Sbjct: 1112 VKLLGPS--SERATPAFHPV-----------CQVIAMYDYAANNEDELSFSKGQLINVMN 1158
Query: 299 KDCIDVGWWEGELNGRRGVFPDNFVKL 325
KD D WW+GE+NG G+FP N+VK+
Sbjct: 1159 KD--DPDWWQGEINGVTGLFPSNYVKM 1183
Score = 83.2 bits (204), Expect = 7e-16
Identities = 62/206 (30%), Positives = 94/206 (45%), Gaps = 50/206 (24%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM-- 60
E I + Y + +LT + GE I + ++DG WW G I R G+FP N+V+ +E
Sbjct: 985 EYIALYPYSSVEPGDLTFTEGEEIL-VTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFG 1043
Query: 61 --KKDPLTNKAPE---KPLHEVPSGNSLLSSET-----ILRTNK----------RGERRR 100
K +NK PE V SG+ LS IL+ N RG++R+
Sbjct: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
Query: 101 RR------------------------CQVA--FSYLPQNDDELELKVGDIIEVVGEVEEG 134
+ CQV + Y N+DEL G +I V+ + +
Sbjct: 1104 KGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPD 1163
Query: 135 WWEGVLNGKTGMFPSNFIKELSGESD 160
WW+G +NG TG+FPSN++K ++ +SD
Sbjct: 1164 WWQGEINGVTGLFPSNYVK-MTTDSD 1188
Score = 72.4 bits (176), Expect = 1e-12
Identities = 71/296 (23%), Positives = 124/296 (41%), Gaps = 50/296 (16%)
Query: 43 GRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR 102
G+ L+ +N +E ++E +K K EK E + T K E++R
Sbjct: 699 GKENLWKENLRKE-EEEKQKRLQEEKTQEKIQEEERKAEEKQRKDK--DTLKAEEKKRET 755
Query: 103 CQVAFSYLP------QNDDELELKVGDIIEVVGEV--EEGWWEGVLNGKTGMFPSNFIKE 154
V +Y +N DE+ GDII+V + E GW G G G FP N++++
Sbjct: 756 ASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEK 815
Query: 155 LSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKV---K 211
+ +E +S K +L T S S ++ST SE + QP V +
Sbjct: 816 MPSSENEKAVSP-----KKALLPPTVSLS----ATSTSSEPLSSN------QPASVTDYQ 860
Query: 212 GVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDY 271
V F ++ N + + + + +P + ++ K++
Sbjct: 861 NVSFSNL--------------TVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQAL 906
Query: 272 CKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLP 327
C + A+ D+ L + DI+T++ + WW GE++G RG FP ++VK++P
Sbjct: 907 CS----WTAKKDNHLNFSKHDIITVLEQQ---ENWWFGEVHGGRGWFPKSYVKIIP 955
Score = 72.4 bits (176), Expect = 1e-12
Identities = 81/377 (21%), Positives = 146/377 (38%), Gaps = 73/377 (19%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDG--GWWEGQINGRRGLFPDNFVREIKKEMKKDPL 65
+ ++A++ DE++ + G+II K G GW G G G FP N+V ++ + +
Sbjct: 766 YPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAV 825
Query: 66 TNKA----PEKPLHEVPSGNSLLSSE-------------TILRTNKRGERRRR------- 101
+ K P L + + LSS + L N +++
Sbjct: 826 SPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSP 885
Query: 102 ----------------RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTG 145
+ Q S+ + D+ L DII V+ E +E WW G ++G G
Sbjct: 886 GSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL-EQQENWWFGEVHGGRG 944
Query: 146 MFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAI 205
FP +++K + G E+ + E L + ++ T + G+ A+
Sbjct: 945 WFPKSYVKIIPGS--EVKREEPEALYAAVNKKPTSAAYSVGEEY-------------IAL 989
Query: 206 QPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDS-----SKT 260
P G + + I + + E + I P+ P S +
Sbjct: 990 YPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGI---FPSNYVKPKDQESFGSAS 1046
Query: 261 EMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGR-----R 315
+ + K + +V Y A ++L++ G ++ ++ K+ GWW+GEL R +
Sbjct: 1047 KSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTS--GWWQGELQARGKKRQK 1104
Query: 316 GVFPDNFVKLLPPDFEK 332
G FP + VKLL P E+
Sbjct: 1105 GWFPASHVKLLGPSSER 1121
Score = 55.1 bits (131), Expect = 2e-07
Identities = 27/83 (32%), Positives = 44/83 (53%), Gaps = 2/83 (2%)
Query: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 332
+ ++P+EA+N DE++ GDI+ + K + GW G G G FP N+V+ +P +
Sbjct: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
Query: 333 EGNRPKKPPPPSAPVIKQGAGTT 355
+ PKK P P + A +T
Sbjct: 823 KAVSPKKALLP--PTVSLSATST 843
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 94.7 bits (234), Expect = 2e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 577 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 636
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 637 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 694
Query: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 695 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 69.7 bits (169), Expect = 8e-12
Identities = 71/300 (23%), Positives = 135/300 (45%), Gaps = 39/300 (13%)
Query: 54 REIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSET---ILRTNKRGERRR----RRCQVA 106
R +K+E ++ + A + +P+ + +++E +L + +R+ R +
Sbjct: 451 RRLKREQEEADI---AARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAK 507
Query: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 166
F + Q EL L+ GDI+ + ++++ W+EG +G+ G+FP +I EL +++ +
Sbjct: 508 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKK 566
Query: 167 DEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKD 221
+ E + GD+ S +G T+ + ++ G IF
Sbjct: 567 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 626
Query: 222 KPIKLRPRSIEVEN--DFLPVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKS 268
+ + R + V+N D++ + + AT + TPD S+T D +
Sbjct: 627 TYVDVIKRPL-VKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY- 684
Query: 269 KDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+ ++ Y QNDDEL +++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 685 ----QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 738
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 501 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 556
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
P KA K L V L E I + N G+ E+ +
Sbjct: 557 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 595
Query: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 596 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 629
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 508 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 562
Query: 336 RPKKPPP 342
+PKK P
Sbjct: 563 QPKKLTP 569
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 94.7 bits (234), Expect = 2e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 618 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 677
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 678 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 735
Query: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 736 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 69.7 bits (169), Expect = 8e-12
Identities = 71/300 (23%), Positives = 135/300 (45%), Gaps = 39/300 (13%)
Query: 54 REIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSET---ILRTNKRGERRR----RRCQVA 106
R +K+E ++ + A + +P+ + +++E +L + +R+ R +
Sbjct: 492 RRLKREQEEADI---AARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAK 548
Query: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 166
F + Q EL L+ GDI+ + ++++ W+EG +G+ G+FP +I EL +++ +
Sbjct: 549 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKK 607
Query: 167 DEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKD 221
+ E + GD+ S +G T+ + ++ G IF
Sbjct: 608 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 667
Query: 222 KPIKLRPRSIEVEN--DFLPVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKS 268
+ + R + V+N D++ + + AT + TPD S+T D +
Sbjct: 668 TYVDVIKRPL-VKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY- 725
Query: 269 KDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+ ++ Y QNDDEL +++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 726 ----QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 779
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 542 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 597
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
P KA K L V L E I + N G+ E+ +
Sbjct: 598 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 636
Query: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 637 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 670
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 549 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 603
Query: 336 RPKKPPP 342
+PKK P
Sbjct: 604 QPKKLTP 610
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 94.7 bits (234), Expect = 2e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 653 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 712
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 713 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 770
Query: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 771 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 77.8 bits (190), Expect = 3e-14
Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 31/281 (11%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125
+ K E P H +P+ + L S+E +R + ++ R + F + Q EL L+ GDI+
Sbjct: 545 STKDSESPRHFIPA-DYLESTEEFIR-RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIV 602
Query: 126 EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDG 185
+ ++++ W+EG +G+ G+FP +I EL +++ + + E +
Sbjct: 603 YIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFN 661
Query: 186 GDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFL 238
GD+ S +G T+ + ++ G IF + + R + V+N D++
Sbjct: 662 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYM 720
Query: 239 PVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELT 287
+ + AT + TPD S+T D + + ++ Y QNDDEL
Sbjct: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELE 775
Query: 288 IKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 776 LRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 577 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 632
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
P KA K L V L E I + N G+ E+ +
Sbjct: 633 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 671
Query: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 672 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
Score = 57.0 bits (136), Expect = 5e-08
Identities = 40/127 (31%), Positives = 65/127 (51%), Gaps = 22/127 (17%)
Query: 233 VENDFLPVEKTIGKKLPATTATPDSSK-------------TEMDSRTKSKDY----CKVI 275
+E +P++ G K P+++A+ S+ TE R + D +
Sbjct: 524 LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAK 583
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 584 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 638
Query: 336 RPKKPPP 342
+PKK P
Sbjct: 639 QPKKLTP 645
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 94.7 bits (234), Expect = 2e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 521 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 580
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 581 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 638
Query: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 639 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 77.8 bits (190), Expect = 3e-14
Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 31/281 (11%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125
+ K E P H +P+ + L S+E +R + ++ R + F + Q EL L+ GDI+
Sbjct: 413 STKDSESPRHFIPA-DYLESTEEFIR-RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIV 470
Query: 126 EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDG 185
+ ++++ W+EG +G+ G+FP +I EL +++ + + E +
Sbjct: 471 YIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFN 529
Query: 186 GDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFL 238
GD+ S +G T+ + ++ G IF + + R + V+N D++
Sbjct: 530 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYM 588
Query: 239 PVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELT 287
+ + AT + TPD S+T D + + ++ Y QNDDEL
Sbjct: 589 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELE 643
Query: 288 IKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 644 LRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 682
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 445 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 500
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
P KA K L V L E I + N G+ E+ +
Sbjct: 501 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 539
Query: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 540 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 573
Score = 57.0 bits (136), Expect = 5e-08
Identities = 40/127 (31%), Positives = 65/127 (51%), Gaps = 22/127 (17%)
Query: 233 VENDFLPVEKTIGKKLPATTATPDSSK-------------TEMDSRTKSKDY----CKVI 275
+E +P++ G K P+++A+ S+ TE R + D +
Sbjct: 392 LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAK 451
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 452 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 506
Query: 336 RPKKPPP 342
+PKK P
Sbjct: 507 QPKKLTP 513
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 92.8 bits (229), Expect = 9e-19
Identities = 58/182 (31%), Positives = 93/182 (51%), Gaps = 29/182 (15%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 722 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 781
Query: 61 KKDPL--------------TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRR----- 101
K+P+ +P+ H + +G L SE + +RR
Sbjct: 782 VKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQQRRVTPDRSQ 841
Query: 102 ------RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIK 153
Q +SY+PQNDDELEL+ GDI++V+ + ++GW+ G + G FP N++K
Sbjct: 842 TSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 901
Query: 154 EL 155
L
Sbjct: 902 PL 903
Score = 81.3 bits (199), Expect = 3e-15
Identities = 82/332 (24%), Positives = 133/332 (40%), Gaps = 80/332 (24%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 646 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 701
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
P KA K L V L E I + N G+ E+ +
Sbjct: 702 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 740
Query: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGIS-QDEQLSKSSLRE 177
G+ I ++ +V+E W+EG + G + G+FP ++ + + + D S S R
Sbjct: 741 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 800
Query: 178 TTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDF 237
T S +L S+ D
Sbjct: 801 ATASP------------------------------------------QLSHHSLRAGPDL 818
Query: 238 LPVEKT-IGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTL 296
EK+ + + TPD S+T D + + ++ Y QNDDEL +++GDIV +
Sbjct: 819 TESEKSYVQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELELRDGDIVDV 873
Query: 297 INKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+ K D GW+ G + G FP N+VK L
Sbjct: 874 MEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 903
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 653 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 707
Query: 336 RPKKPPP 342
+PKK P
Sbjct: 708 QPKKLTP 714
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 85.9 bits (211), Expect = 1e-16
Identities = 49/174 (28%), Positives = 83/174 (47%), Gaps = 28/174 (16%)
Query: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKE-DGGWWEGQINGRRGLFPDNFVREIKKEM 60
+EAI ++D++A DDEL+ G+I+ + +E D W++ ++NG+ G P N++ EM
Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI-----EM 55
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLL----------------------SSETILRTNKRGER 98
K P N + +G L + + LR ++ +
Sbjct: 56 KPHPFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQ 115
Query: 99 RRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFI 152
+ Q F + PQ D EL + GD I V+ + WW+G +G+TGMFP N++
Sbjct: 116 QPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYV 169
Score = 56.6 bits (135), Expect = 7e-08
Identities = 27/78 (34%), Positives = 46/78 (58%), Gaps = 9/78 (11%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
+ ++A DDEL+ K GDI+ ++N++C D W++ ELNG+ G P N++++ P F +
Sbjct: 7 YDFKATADDELSFKRGDILKVLNEEC-DQNWYKAELNGKDGFIPKNYIEMKPHPFGNDVQ 65
Query: 336 RPKKPPPPSAPVIKQGAG 353
K V++ GAG
Sbjct: 66 HFK--------VLRDGAG 75
Score = 46.6 bits (109), Expect = 7e-05
Identities = 18/53 (33%), Positives = 32/53 (60%), Gaps = 2/53 (3%)
Query: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV 323
Y + +F ++ Q D EL + GD + +++ D WW+G +G+ G+FP N+V
Sbjct: 119 YVQALFDFDPQEDGELGFRRGDFIHVMDNS--DPNWWKGACHGQTGMFPRNYV 169
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/53 (33%), Positives = 29/53 (54%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
FD+ Q D EL G+ I + D WW+G +G+ G+FP N+V + + +
Sbjct: 124 FDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV 176
Score = 43.9 bits (102), Expect = 5e-04
Identities = 19/41 (46%), Positives = 28/41 (68%), Gaps = 1/41 (2%)
Query: 114 DDELELKVGDIIEVVGE-VEEGWWEGVLNGKTGMFPSNFIK 153
DDEL K GDI++V+ E ++ W++ LNGK G P N+I+
Sbjct: 14 DDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 85.1 bits (209), Expect = 2e-16
Identities = 79/325 (24%), Positives = 144/325 (44%), Gaps = 46/325 (14%)
Query: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
A ++FD+QAQ ELT+ G+I+ ++ D W EG+ +GR G+FP N+V + +
Sbjct: 385 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 444
Query: 64 PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGD 123
P+ KP P+ L E + + +G+ + EL + G+
Sbjct: 445 PI------KP----PTYQVLEYGEAVAQYTFKGDL---------------EVELSFRKGE 479
Query: 124 IIEVVGEVEEGWWEGVL--NGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGS 181
I ++ +V E W+EG + G+ G+FP+++++ L + D +S R T +
Sbjct: 480 HICLIRKVNENWYEGRITGTGRQGIFPASYVQ--VSREPRLRLCDDGPQLPTSPRLTAAA 537
Query: 182 ESDGGDSS-STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 240
S SS S A+ P++ G F + + + +++ L
Sbjct: 538 RSARHPSSPSALRSPADPIDLGGQTSPRRT-----GFSFPTQEPRPQTQNLGTPGPALSH 592
Query: 241 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 300
+ L T++P++S+ + ++ Y QN+DEL ++EGD V ++ +
Sbjct: 593 SRGPSHPLDLGTSSPNTSQIHWTP-------YRAMYQYRPQNEDELELREGDRVDVMQQ- 644
Query: 301 CIDVGWWEG--ELNGRRGVFPDNFV 323
D GW+ G + G FP N+V
Sbjct: 645 -CDDGWFVGVSRRTQKFGTFPGNYV 668
Score = 65.9 bits (159), Expect = 1e-10
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 65/255 (25%)
Query: 249 PATTATPDSSK---TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG 305
P++T P +S + K + ++ F ++AQ+ ELT+++GDIV I+K+ +D
Sbjct: 359 PSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIV-YIHKE-VDKN 416
Query: 306 WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTE--------- 356
W EGE +GR G+FP N+V++LP D PK PP+ V++ G +
Sbjct: 417 WLEGEHHGRLGIFPANYVEVLPAD-----EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEV 471
Query: 357 ----RKHE----IKKIPPERPEMLPNRTEEK-------ERPEREPKLDL--QKPSVPAIP 399
RK E I+K+ E T + + REP+L L P +P P
Sbjct: 472 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSP 531
Query: 400 -----PKKPRPPKTNSLSRPGALP----------------PRRPERP-------VGP-LT 430
+ R P + S R A P P + RP GP L+
Sbjct: 532 RLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALS 591
Query: 431 HTRGDSPKIDLAGSS 445
H+RG S +DL SS
Sbjct: 592 HSRGPSHPLDLGTSS 606
Score = 54.3 bits (129), Expect = 4e-07
Identities = 22/65 (33%), Positives = 43/65 (66%)
Query: 94 KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
+R E++R+ ++ F + Q+ EL L+ GDI+ + EV++ W EG +G+ G+FP+N+++
Sbjct: 376 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 435
Query: 154 ELSGE 158
L +
Sbjct: 436 VLPAD 440
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/73 (31%), Positives = 43/73 (58%), Gaps = 4/73 (5%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKKEM 60
EA+ ++ ++ + EL+ GE I IRK + W+EG+I GR+G+FP ++V+ ++
Sbjct: 458 EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPR 517
Query: 61 KKDPLTNKAPEKP 73
+ L + P+ P
Sbjct: 518 LR--LCDDGPQLP 528
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 85.1 bits (209), Expect = 2e-16
Identities = 79/325 (24%), Positives = 144/325 (44%), Gaps = 46/325 (14%)
Query: 4 AIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKD 63
A ++FD+QAQ ELT+ G+I+ ++ D W EG+ +GR G+FP N+V + +
Sbjct: 43 ARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPK 102
Query: 64 PLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGD 123
P+ KP P+ L E + + +G+ + EL + G+
Sbjct: 103 PI------KP----PTYQVLEYGEAVAQYTFKGDL---------------EVELSFRKGE 137
Query: 124 IIEVVGEVEEGWWEGVL--NGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGS 181
I ++ +V E W+EG + G+ G+FP+++++ L + D +S R T +
Sbjct: 138 HICLIRKVNENWYEGRITGTGRQGIFPASYVQ--VSREPRLRLCDDGPQLPTSPRLTAAA 195
Query: 182 ESDGGDSS-STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPV 240
S SS S A+ P++ G F + + + +++ L
Sbjct: 196 RSARHPSSPSALRSPADPIDLGGQTSPRRT-----GFSFPTQEPRPQTQNLGTPGPALSH 250
Query: 241 EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKD 300
+ L T++P++S+ + ++ Y QN+DEL ++EGD V ++ +
Sbjct: 251 SRGPSHPLDLGTSSPNTSQIHWTP-------YRAMYQYRPQNEDELELREGDRVDVMQQ- 302
Query: 301 CIDVGWWEG--ELNGRRGVFPDNFV 323
D GW+ G + G FP N+V
Sbjct: 303 -CDDGWFVGVSRRTQKFGTFPGNYV 326
Score = 65.9 bits (159), Expect = 1e-10
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 65/255 (25%)
Query: 249 PATTATPDSSK---TEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVG 305
P++T P +S + K + ++ F ++AQ+ ELT+++GDIV I+K+ +D
Sbjct: 17 PSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTLQKGDIV-YIHKE-VDKN 74
Query: 306 WWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTE--------- 356
W EGE +GR G+FP N+V++LP D PK PP+ V++ G +
Sbjct: 75 WLEGEHHGRLGIFPANYVEVLPAD-----EIPKPIKPPTYQVLEYGEAVAQYTFKGDLEV 129
Query: 357 ----RKHE----IKKIPPERPEMLPNRTEEK-------ERPEREPKLDL--QKPSVPAIP 399
RK E I+K+ E T + + REP+L L P +P P
Sbjct: 130 ELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSP 189
Query: 400 -----PKKPRPPKTNSLSRPGALP----------------PRRPERP-------VGP-LT 430
+ R P + S R A P P + RP GP L+
Sbjct: 190 RLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALS 249
Query: 431 HTRGDSPKIDLAGSS 445
H+RG S +DL SS
Sbjct: 250 HSRGPSHPLDLGTSS 264
Score = 54.3 bits (129), Expect = 4e-07
Identities = 22/65 (33%), Positives = 43/65 (66%)
Query: 94 KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK 153
+R E++R+ ++ F + Q+ EL L+ GDI+ + EV++ W EG +G+ G+FP+N+++
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 154 ELSGE 158
L +
Sbjct: 94 VLPAD 98
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/73 (31%), Positives = 43/73 (58%), Gaps = 4/73 (5%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQI--NGRRGLFPDNFVREIKKEM 60
EA+ ++ ++ + EL+ GE I IRK + W+EG+I GR+G+FP ++V+ ++
Sbjct: 116 EAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPR 175
Query: 61 KKDPLTNKAPEKP 73
+ L + P+ P
Sbjct: 176 LR--LCDDGPQLP 186
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 85.1 bits (209), Expect = 2e-16
Identities = 89/366 (24%), Positives = 146/366 (39%), Gaps = 73/366 (19%)
Query: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 817 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 872
Query: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
P KA K L V L E I + N G+ E+ +
Sbjct: 873 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 911
Query: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFIKELSGESDELGIS-QDEQLSKSSLRE 177
G+ I ++ +V+E W+EG + G + G+FP ++ + + + D S S R
Sbjct: 912 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRS 971
Query: 178 TTGSESDGGDSS---STKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVE 234
T S + S K+E G + K + D+ + + R +
Sbjct: 972 ATASPQPWREESGQYERKAERGAGERGPGGPKISKKSCLKPSDVVRCLSTEQRLSDLNTP 1031
Query: 235 NDFLPVEKTIGKKLPATTA--------------------------------TPDSSKTEM 262
+ P K +G P + A TPD S+T
Sbjct: 1032 EESRP-GKPLGSAFPGSEAEQTERHRGGEQAGRKAARRGGSQQPQAQQRRVTPDRSQTSQ 1090
Query: 263 DSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPD 320
D + + ++ Y QNDDEL +++GDIV ++ K D GW+ G + G FP
Sbjct: 1091 DLFS-----YQALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPG 1143
Query: 321 NFVKLL 326
N+VK L
Sbjct: 1144 NYVKPL 1149
Score = 55.1 bits (131), Expect = 2e-07
Identities = 29/67 (43%), Positives = 43/67 (64%), Gaps = 5/67 (7%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 824 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 878
Query: 336 RPKKPPP 342
+PKK P
Sbjct: 879 QPKKLTP 885
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 84.7 bits (208), Expect = 2e-16
Identities = 57/214 (26%), Positives = 96/214 (44%), Gaps = 29/214 (13%)
Query: 12 AQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV----------REIKKEMK 61
AQ D+EL G++IT I + GW+EG++ GRRG+FP+ FV + +
Sbjct: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQ 217
Query: 62 KDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
D + N + P+ E G ++ E + + +EL+ +V
Sbjct: 218 DDCIVNGEVDTPVGEEEIG-----------PDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 122 GDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK--------ELSGESDELGISQDEQLSKS 173
GD I ++ +E+GW EG L G+TG+FP F+K E E +++ + S
Sbjct: 267 GDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSLD 326
Query: 174 SLRETTGSESDGGDSSSTKSEGANGTVATAAIQP 207
L T G E ++S ++E + ++ A P
Sbjct: 327 CLENTLGVEEQRHETSDHEAEEPDCIISEAPTSP 360
Score = 80.1 bits (196), Expect = 6e-15
Identities = 85/372 (22%), Positives = 140/372 (37%), Gaps = 103/372 (27%)
Query: 9 DYQAQHDDELTISVGEIITNIRKEDGGWWEGQIN-GRRGLFPDNFVREIKKEMKKDPLTN 67
++ +Q D L + G+++ GW +G+ G RG FP + VRE+ + +
Sbjct: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
++ L ++P E + + Q D+EL+ + GD+I +
Sbjct: 136 QSA---LFQIP------------------EYSMGQARALMGLSAQLDEELDFREGDVITI 174
Query: 128 VGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGD 187
+G E GW+EG L G+ G+FP F++ L LR S S G
Sbjct: 175 IGVPEPGWFEGELEGRRGIFPEGFVELLG-----------------PLRTVDESVSSGNQ 217
Query: 188 SSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKK 247
NG V D P+ E+ IG
Sbjct: 218 DDCI----VNGEV--------------------DTPVG---------------EEEIG-- 236
Query: 248 LPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWW 307
PD + E + Y ++ ++A +EL + GD + ++ ++ GW
Sbjct: 237 -------PDEDEEEPGT------YGVALYRFQALEPNELDFEVGDKIRILAT--LEDGWL 281
Query: 308 EGELNGRRGVFPDNFVKLLPPD-------FEKEGNRPKKPPPPSAPVIKQGAGTTERKHE 360
EG L GR G+FP FVKL P +EG+ + P S ++ G E++HE
Sbjct: 282 EGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSL-ARIPETSLDCLENTLGVEEQRHE 340
Query: 361 IKKIPPERPEML 372
E P+ +
Sbjct: 341 TSDHEAEEPDCI 352
Score = 79.0 bits (193), Expect = 1e-14
Identities = 64/222 (28%), Positives = 94/222 (42%), Gaps = 28/222 (12%)
Query: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 166
F + P +EL L VGDIIEV+ V+E W G TG FPS+F++ ++ S + +
Sbjct: 11 FDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPS----LKE 66
Query: 167 DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 226
E+L + E T E D +G +Q + G
Sbjct: 67 GERLFVC-ICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGA------------- 112
Query: 227 RPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDEL 286
F P L + + S S + + AQ D+EL
Sbjct: 113 --------RGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEEL 164
Query: 287 TIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP 328
+EGD++T+I + GW+EGEL GRRG+FP+ FV+LL P
Sbjct: 165 DFREGDVITIIGVP--EPGWFEGELEGRRGIFPEGFVELLGP 204
Score = 41.6 bits (96), Expect = 0.002
Identities = 20/77 (25%), Positives = 40/77 (51%), Gaps = 3/77 (3%)
Query: 251 TTATPDSSKTEMD-SRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLIN-KDCI-DVGWW 307
T P+ TE D S + ++ ++A+N +EL++ + ++ KD + WW
Sbjct: 1496 TAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWW 1555
Query: 308 EGELNGRRGVFPDNFVK 324
E+NG++G P N+++
Sbjct: 1556 LAEVNGKKGYVPSNYIR 1572
Score = 40.8 bits (94), Expect = 0.004
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR 54
+ +QA +EL VG+ I + + GW EG + GR G+FP FV+
Sbjct: 252 YRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVK 298
Score = 36.2 bits (82), Expect = 0.100
Identities = 13/52 (25%), Positives = 32/52 (61%), Gaps = 4/52 (7%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKED----GGWWEGQINGRRGLFPDNFVRE 55
+ ++A++ +EL++S + + + +D WW ++NG++G P N++R+
Sbjct: 1522 YTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573
Score = 35.4 bits (80), Expect = 0.17
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 8/54 (14%)
Query: 107 FSYLPQNDDEL------ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKE 154
+++ +N +EL +LK+ + +V G E WW +NGK G PSN+I++
Sbjct: 1522 YTFKARNPNELSVSANQKLKILEFKDVTGNTE--WWLAEVNGKKGYVPSNYIRK 1573
Score = 32.0 bits (71), Expect = 1.9
Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 2/64 (3%)
Query: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 332
+ IF + +EL + GDI+ ++ +D W G+ G FP +FV+++ K
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLA--VVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65
Query: 333 EGNR 336
EG R
Sbjct: 66 EGER 69
>gi|55749544 SH3 multiple domains 1 [Homo sapiens]
Length = 1105
Score = 84.0 bits (206), Expect = 4e-16
Identities = 151/700 (21%), Positives = 260/700 (37%), Gaps = 146/700 (20%)
Query: 5 IVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDP 64
+V +Y+ Q + EL++ GE++ I K + GWW + +G P ++
Sbjct: 172 VVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYL----------- 220
Query: 65 LTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDI 124
E +G ++ + T+K GE + Y Q+ DE+ + G
Sbjct: 221 -----------EAQNGT---RDDSDINTSKTGE--EEKYVTVQPYTSQSKDEIGFEKGVT 264
Query: 125 IEVVGEVEEGWWEGVLNGKTGMFPSNFIKE-----------LSGESDELG----ISQDEQ 169
+EV+ + EGWW GK G P++++K+ L+G + +G IS
Sbjct: 265 VEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLN 324
Query: 170 LSKSSLRETTGSESDGGDSSSTKSE--------GANGTVATAAIQPKKVKGVGFGDIFKD 221
S +ET +E +G ++ K E +NG + + + V + G
Sbjct: 325 KKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNG--SAVGVPDRTVSRLAQG---SP 379
Query: 222 KPIKLRPRSIEVENDFLPV------EKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVI 275
++ P+ ++ + L E ++G +LP P+ E++ T I
Sbjct: 380 AVARIAPQRAQISSPNLRTRPPPRRESSLGFQLP---KPPEPPSVEVEYYT--------I 428
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KLLPPDFEKEG 334
+++ D ++ + G +I+K+ GWW ++ + G P +++ K P+ +
Sbjct: 429 AEFQSCISDGISFRGGQKAEVIDKN--SGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRT 486
Query: 335 N---RPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPER----EPK 387
+ RPK PPP AP K P E E +E ++ P + EP+
Sbjct: 487 STLTRPKVPPP--APPSK---------------PKEAEEGPTGASESQDSPRKLKYEEPE 529
Query: 388 LDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLS 447
D+ + P P + + G P +P RP SP L +
Sbjct: 530 YDIPAFGFDSEPELSEEPVEDRA---SGERRPAQPHRP----------SPASSLQRARFK 576
Query: 448 GILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLS----- 502
+ + S D+ LE + + E A G S S SSSLS
Sbjct: 577 ------VGESSEDVALE--EETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKN 628
Query: 503 SPDIFDSPSPEED-----KEEHISLAHRGVD-ASKKTSKTVTISQVSDNKASLPPKPGTM 556
SP S SP+ K E + A G + +S S ++TI+ + +S +
Sbjct: 629 SP---KSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSK 685
Query: 557 AAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEP-----AASSQAA--- 608
+G P S A AN+ KP + P A SQ+
Sbjct: 686 TSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKM 745
Query: 609 -VEELRTQVR---ELRSIIETMKDQQKREIKQLLSELDEE 644
+ LR Q+R +LR ++ K + Q SE E
Sbjct: 746 DISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSE 785
Score = 36.6 bits (83), Expect = 0.076
Identities = 48/198 (24%), Positives = 74/198 (37%), Gaps = 21/198 (10%)
Query: 44 RRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILR---------TNK 94
RR L P +R K K + ++ P + E PS S SS ++ T K
Sbjct: 751 RRQLRPTGQLRGGLKGSKSED--SELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKK 808
Query: 95 RGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNF-IK 153
E +Y D E+ G ++V+ + E GWW G PS++ +
Sbjct: 809 EWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVL 868
Query: 154 ELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGAN----GTVATAAIQPKK 209
+ + + D G D +K E +SD + + + N AT I P K
Sbjct: 869 DENEQPDPSGKELDTVPAKGRQNE---GKSDSLEKIERRVQALNTVNQSKKATPPI-PSK 924
Query: 210 VKGVGFGDIFKDKPIKLR 227
G GFG +K+R
Sbjct: 925 PPG-GFGKTSGTPAVKMR 941
Score = 34.3 bits (77), Expect = 0.38
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 1/79 (1%)
Query: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKK-EM 60
VE ++Q+ D ++ G+ I K GGWW QI + G P +++ + KK +
Sbjct: 423 VEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNL 482
Query: 61 KKDPLTNKAPEKPLHEVPS 79
+ T P+ P PS
Sbjct: 483 SRRTSTLTRPKVPPPAPPS 501
Score = 30.4 bits (67), Expect = 5.5
Identities = 11/44 (25%), Positives = 21/44 (47%)
Query: 10 YQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV 53
YQ D E++ G + + K++ GWW + G P +++
Sbjct: 823 YQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYL 866
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 334 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 393
Query: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 394 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 450
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 451 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 255 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 312
Query: 326 LPPDFEKEGNRPKKPPPPSAP 346
PP E +P +PPPP+ P
Sbjct: 313 TPP----EKAQPARPPPPAQP 329
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 264 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 323
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
P +P + GE + +++ + EL L+ GD + +
Sbjct: 324 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 359
Query: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
+ V++ W+EG + G + G+FP ++++
Sbjct: 360 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 387
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 215 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 274
Query: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 275 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 334
Query: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 335 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 394
Query: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 395 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 454
Query: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 455 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 492
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 339 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 396
Query: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
+ P P P S +++R H + P+RP P + P
Sbjct: 397 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 448
Query: 385 EPKLDLQKPSV 395
E +L+L++ V
Sbjct: 449 EDELELRESDV 459
Score = 34.7 bits (78), Expect = 0.29
Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 17/189 (8%)
Query: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384
P+ K+ + P PP PP P ++ ++ KH+ PP+R + R+E + E
Sbjct: 77 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 134
Query: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432
EP K + + PA I RP + S++ R + P P R +G + +
Sbjct: 135 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 194
Query: 433 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPP 492
R ++DL GSS + S S+ + +S S + L+ S P+ P
Sbjct: 195 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 254
Query: 493 SQSLTSSSL 501
+ L + ++
Sbjct: 255 KEKLPAKAV 263
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 846 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 905
Query: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 906 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 962
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 963 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 767 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 824
Query: 326 LPPDFEKEGNRPKKPPPPSAP 346
PP E +P +PPPP+ P
Sbjct: 825 TPP----EKAQPARPPPPAQP 841
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 776 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 835
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
P +P + GE + +++ + EL L+ GD + +
Sbjct: 836 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 871
Query: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
+ V++ W+EG + G + G+FP ++++
Sbjct: 872 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 899
Score = 61.6 bits (148), Expect = 2e-09
Identities = 46/241 (19%), Positives = 104/241 (43%), Gaps = 13/241 (5%)
Query: 97 ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS 156
E+ + + + + Q EL K GD + ++ ++++ W+EG +G+ G+FP +++++L+
Sbjct: 766 EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLT 825
Query: 157 GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVK 211
+ E + D++ S +G + Q K+
Sbjct: 826 PPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIP 885
Query: 212 GVGFGDIFKDKPIKLRPRSIEVENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTK 267
G IF +++ ++ + D+ +P + + ++ P ++
Sbjct: 886 GTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQG 945
Query: 268 SKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKL 325
+ + ++ Y +N+DEL ++E D++ ++ K D GW+ G + G FP N+VK
Sbjct: 946 GGEPFQALYNYTPRNEDELELRESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKR 1003
Query: 326 L 326
L
Sbjct: 1004 L 1004
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 851 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 908
Query: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
+ P P P S +++R H + P+RP P + P
Sbjct: 909 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 960
Query: 385 EPKLDLQKPSV 395
E +L+L++ V
Sbjct: 961 EDELELRESDV 971
Score = 32.3 bits (72), Expect = 1.4
Identities = 36/133 (27%), Positives = 59/133 (44%), Gaps = 17/133 (12%)
Query: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384
P+ K+ + P PP PP P ++ ++ KH+ PP+R + R+E + E
Sbjct: 62 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 119
Query: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432
EP K + + PA I RP + S++ R + P P R +G + +
Sbjct: 120 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 179
Query: 433 RGDSPKIDLAGSS 445
R ++DL GSS
Sbjct: 180 RTSPGRVDLPGSS 192
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 666 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 725
Query: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 726 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 782
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 783 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 587 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 644
Query: 326 LPPDFEKEGNRPKKPPPPSAP 346
PP E +P +PPPP+ P
Sbjct: 645 TPP----EKAQPARPPPPAQP 661
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 596 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 655
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
P +P + GE + +++ + EL L+ GD + +
Sbjct: 656 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 691
Query: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
+ V++ W+EG + G + G+FP ++++
Sbjct: 692 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 719
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 547 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 606
Query: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 607 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 666
Query: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 667 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 726
Query: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 727 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 786
Query: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 787 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 824
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 671 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 728
Query: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
+ P P P S +++R H + P+RP P + P
Sbjct: 729 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 780
Query: 385 EPKLDLQKPSV 395
E +L+L++ V
Sbjct: 781 EDELELRESDV 791
Score = 40.8 bits (94), Expect = 0.004
Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 50/225 (22%)
Query: 328 PDFEKEGNRPKKPP---PPSAPVIKQGAGTTE--------RKHEIKK------------- 363
P+ K+ + P PP PP P+ + +TE RK + +K
Sbjct: 337 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 396
Query: 364 -----IPPERPEMLPNR-TEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGAL 417
+ ERP LP T P R+P + V P PR SR AL
Sbjct: 397 GKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPAL 456
Query: 418 PPRRPERPVGPL----THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSST 473
P RP P PL H+ G + L SS+ L++ +S S D
Sbjct: 457 SPTRP--PKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFR--------K 506
Query: 474 EKLSHPTTSRPKATGRRPPSQS------LTSSSLSSPDIFDSPSP 512
+ S P P+ G + S++ L SS + F S SP
Sbjct: 507 RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 551
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 503 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 562
Query: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 563 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 619
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 620 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 424 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 481
Query: 326 LPPDFEKEGNRPKKPPPPSAP 346
PP E +P +PPPP+ P
Sbjct: 482 TPP----EKAQPARPPPPAQP 498
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 433 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 492
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
P +P + GE + +++ + EL L+ GD + +
Sbjct: 493 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 528
Query: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
+ V++ W+EG + G + G+FP ++++
Sbjct: 529 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 556
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 384 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 443
Query: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
Query: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 563
Query: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 564 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 623
Query: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 624 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 508 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 565
Query: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
+ P P P S +++R H + P+RP P + P
Sbjct: 566 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 617
Query: 385 EPKLDLQKPSV 395
E +L+L++ V
Sbjct: 618 EDELELRESDV 628
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 573 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 632
Query: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 633 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 689
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 690 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 494 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 551
Query: 326 LPPDFEKEGNRPKKPPPPSAP 346
PP E +P +PPPP+ P
Sbjct: 552 TPP----EKAQPARPPPPAQP 568
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 503 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 562
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
P +P + GE + +++ + EL L+ GD + +
Sbjct: 563 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 598
Query: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
+ V++ W+EG + G + G+FP ++++
Sbjct: 599 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 626
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 454 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 513
Query: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 514 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 573
Query: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 574 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 633
Query: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 634 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 693
Query: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 694 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 731
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 578 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 635
Query: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
+ P P P S +++R H + P+RP P + P
Sbjct: 636 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 687
Query: 385 EPKLDLQKPSV 395
E +L+L++ V
Sbjct: 688 EDELELRESDV 698
Score = 40.8 bits (94), Expect = 0.004
Identities = 57/225 (25%), Positives = 80/225 (35%), Gaps = 50/225 (22%)
Query: 328 PDFEKEGNRPKKPP---PPSAPVIKQGAGTTE--------RKHEIKK------------- 363
P+ K+ + P PP PP P+ + +TE RK + +K
Sbjct: 244 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEP 303
Query: 364 -----IPPERPEMLPNR-TEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGAL 417
+ ERP LP T P R+P + V P PR SR AL
Sbjct: 304 GKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTPSSRAPAL 363
Query: 418 PPRRPERPVGPL----THTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSST 473
P RP P PL H+ G + L SS+ L++ +S S D
Sbjct: 364 SPTRP--PKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFR--------K 413
Query: 474 EKLSHPTTSRPKATGRRPPSQS------LTSSSLSSPDIFDSPSP 512
+ S P P+ G + S++ L SS + F S SP
Sbjct: 414 RRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 458
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 82.8 bits (203), Expect = 9e-16
Identities = 50/162 (30%), Positives = 90/162 (55%), Gaps = 12/162 (7%)
Query: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
EAI ++++ A + EL++ G+ + +++ D W+EG+I G R+G+FP ++V +KK
Sbjct: 486 EAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNT 545
Query: 61 KKDPLTNKAPEKPLHEVPSGNSL--LSSETILR---TNKRGERRRRRCQVAFSYLPQNDD 115
K P+ P+ S + + LSS R T++ + Q ++Y P+N+D
Sbjct: 546 KG---AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNED 602
Query: 116 ELELKVGDIIEVVGEVEEGWWEGVLNGKT--GMFPSNFIKEL 155
ELEL+ D+I+V+ + ++GW+ G G FP N++K L
Sbjct: 603 ELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 66.2 bits (160), Expect = 9e-11
Identities = 35/81 (43%), Positives = 51/81 (62%), Gaps = 7/81 (8%)
Query: 267 KSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFV-KL 325
K K K ++ ++AQ EL+ K+GD V ++ K ID W+EGE +GR G+FP ++V KL
Sbjct: 407 KEKLPAKAVYDFKAQTSKELSFKKGDTVYILRK--IDQNWYEGEHHGRVGIFPISYVEKL 464
Query: 326 LPPDFEKEGNRPKKPPPPSAP 346
PP E +P +PPPP+ P
Sbjct: 465 TPP----EKAQPARPPPPAQP 481
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/148 (25%), Positives = 73/148 (49%), Gaps = 26/148 (17%)
Query: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN 67
+D++AQ EL+ G+ + +RK D W+EG+ +GR G+FP ++V ++ K P
Sbjct: 416 YDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARP 475
Query: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
P +P + GE + +++ + EL L+ GD + +
Sbjct: 476 PPPAQP-------------------GEIGEAIAK-----YNFNADTNVELSLRKGDRVIL 511
Query: 128 VGEVEEGWWEGVLNG--KTGMFPSNFIK 153
+ V++ W+EG + G + G+FP ++++
Sbjct: 512 LKRVDQNWYEGKIPGTNRQGIFPVSYVE 539
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/280 (18%), Positives = 114/280 (40%), Gaps = 21/280 (7%)
Query: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRR--------CQVAFSYLPQNDDEL 117
T+ +P P + S T+ + R RR + + + Q EL
Sbjct: 367 TSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKEL 426
Query: 118 ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRE 177
K GD + ++ ++++ W+EG +G+ G+FP +++++L+ + E
Sbjct: 427 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 486
Query: 178 TTGSESDGGDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIE 232
+ D++ S +G + Q K+ G IF +++ ++ +
Sbjct: 487 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTK 546
Query: 233 VENDF----LPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTI 288
D+ +P + + ++ P ++ + + ++ Y +N+DEL +
Sbjct: 547 GAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELEL 606
Query: 289 KEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
+E D++ ++ K D GW+ G + G FP N+VK L
Sbjct: 607 RESDVIDVMEK--CDDGWFVGTSRRTKFFGTFPGNYVKRL 644
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/131 (24%), Positives = 65/131 (49%), Gaps = 21/131 (16%)
Query: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNG--RRGVFPDNFVKLLPPDFEKE 333
+ + A + EL++++GD V L+ + +D W+EG++ G R+G+FP ++V+++ + +
Sbjct: 491 YNFNADTNVELSLRKGDRVILLKR--VDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGA 548
Query: 334 GNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEML---------PNRTEEKERPER 384
+ P P P S +++R H + P+RP P + P
Sbjct: 549 EDYPDPPIPHSY--------SSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 600
Query: 385 EPKLDLQKPSV 395
E +L+L++ V
Sbjct: 601 EDELELRESDV 611
Score = 34.7 bits (78), Expect = 0.29
Identities = 45/189 (23%), Positives = 79/189 (41%), Gaps = 17/189 (8%)
Query: 328 PDFEKEGNRPKKPP--PPSAPVIKQGAGTTERKHEIKKIPPERP-EMLPNRTEEKERPER 384
P+ K+ + P PP PP P ++ ++ KH+ PP+R + R+E + E
Sbjct: 229 PNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWD--PPDRKVDTRKFRSEPRSIFEY 286
Query: 385 EP-KLDLQKPSVPA------IPPKKPRPPKTNSLS-----RPGALPPRRPERPVGPLTHT 432
EP K + + PA I RP + S++ R + P P R +G + +
Sbjct: 287 EPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSAS 346
Query: 433 RGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPP 492
R ++DL GSS + S S+ + +S S + L+ S P+ P
Sbjct: 347 RTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRERRGTPE 406
Query: 493 SQSLTSSSL 501
+ L + ++
Sbjct: 407 KEKLPAKAV 415
>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
sapiens]
Length = 645
Score = 82.8 bits (203), Expect = 9e-16
Identities = 92/330 (27%), Positives = 135/330 (40%), Gaps = 74/330 (22%)
Query: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 332
+V+F Y+ + DEL ++ GD+V +++K D GWWEGE GRRGVFPDNFV L PP +K
Sbjct: 76 RVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV-LPPPPIKK 134
Query: 333 EGNR------------PKK-PPPPSAPVIKQ--GAGTTERKHEIKKIPPERPEML----- 372
R PKK P S P +K+ A T K + + P + L
Sbjct: 135 LVPRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQKLTSRDS 194
Query: 373 -------------PNRTEEKERPEREPKLDLQKP--SVPAIPP---KKPRPPKTNSLSRP 414
P R K + ++ + Q+ S P P + P P KT + RP
Sbjct: 195 GPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPDKTATPERP 254
Query: 415 GALPPRRPER---------PVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEG 465
A P P P T T GD K + G+S SG +
Sbjct: 255 PA-PENAPSSKKIPAPDKVPSPEKTLTLGD--KASIPGNSTSGKIPA------------- 298
Query: 466 FDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPD----IFDSP---SPEEDKEE 518
V + EK+ P P ++LT S+P+ + +SP +P DK
Sbjct: 299 -PDKVPTPEKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEESPALEAPPMDKVP 357
Query: 519 HISLAHRGVDASKKTSKTVTISQVSDNKAS 548
+ +A G +A T + V ++S+ + S
Sbjct: 358 NPKMAPLGDEA--PTLEKVLTPELSEEEVS 385
Score = 82.0 bits (201), Expect = 2e-15
Identities = 160/694 (23%), Positives = 253/694 (36%), Gaps = 137/694 (19%)
Query: 29 IRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKK-----DPLTNKAPEKPLHEVPSGNSL 83
I++ + GWW G+ NG+ G FP NFV + P + P++P P +SL
Sbjct: 2 IKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQRP----PKLSSL 57
Query: 84 L--SSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEE--GWWEGV 139
S L+T E R V F Y P+ DEL L+ GD+++V+ + E GWWEG
Sbjct: 58 AYDSPPDYLQTVSHPEVYR----VLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGE 113
Query: 140 LNGKTGMFPSNFI------------KELSGESDELGISQDEQLSKSSL-------RETTG 180
G+ G+FP NF+ K +S ES + + + K+SL TTG
Sbjct: 114 CQGRRGVFPDNFVLPPPPIKKLVPRKVVSRESAPIK-EPKKLMPKTSLPTVKKLATATTG 172
Query: 181 ------SESDGGDSS--STKSEGANGTVAT----------AAIQPKKVKGVGFGDIFKDK 222
S + DS +++ G NG + + Q + + V +
Sbjct: 173 PSKAKTSRTPSRDSQKLTSRDSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSS 232
Query: 223 PIK--------LRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKT----EMDSRTKSKD 270
P+K + ++ E P KK+PA P KT + S +
Sbjct: 233 PVKAPSVKRTPMPDKTATPERPPAPENAPSSKKIPAPDKVPSPEKTLTLGDKASIPGNST 292
Query: 271 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDF 330
K+ P + +++ E D ++ I E L + P+ +
Sbjct: 293 SGKIPAPDKVPTPEKMVTPE-DKASIPENSIIP----EETLTVDKPSTPERVFSVEESPA 347
Query: 331 EKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDL 390
+ K P P AP + A T E K + PE E + ++ + + L
Sbjct: 348 LEAPPMDKVPNPKMAP-LGDEAPTLE-----KVLTPELSEEEVSTRDDIQFHHFSSEEAL 401
Query: 391 QKPSVPAIPPKKPRPPKTNSLSRPGALPPRRP--ERPVGPL--THTRGDSPKIDLAGSSL 446
QK K P P A PP+ P ER +G + T RGDS
Sbjct: 402 QKVKYFV---AKEDPSSQEEAHTPEAPPPQPPSSERCLGEMKCTLVRGDS---------- 448
Query: 447 SGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDI 506
S R ++ + S P +P P + T+ +P
Sbjct: 449 --------SPRQAEL----------KSGPASRPALEKPH------PHEEATTLPEEAPS- 483
Query: 507 FDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPL 566
D +PEE+ + R + + V + K LPPK AP
Sbjct: 484 NDERTPEEEAPPN---EQRPLREEVLPKEGVASKEEVTLKEELPPKEEV--------APK 532
Query: 567 SSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQ-----AAVEELRTQVRELRS 621
P + + T + P T P + P ++ V LR +V LR
Sbjct: 533 EEVPPIERAFAQKTRPIKP-PPDSQETLALPSLVPQNYTENKNEGVDVTSLRGEVESLRR 591
Query: 622 IIETMKDQQKREIKQLLSELDEEKKIRLRLQMEV 655
+E M+ Q +R++ + EL EK+ R RL+++V
Sbjct: 592 ALELMEVQLERKLTDIWEELKSEKEQRRRLEVQV 625
Score = 61.2 bits (147), Expect = 3e-09
Identities = 35/95 (36%), Positives = 52/95 (54%), Gaps = 12/95 (12%)
Query: 6 VEFDYQAQHDDELTISVGEIITNIRK--EDGGWWEGQINGRRGLFPDNFVRE-------- 55
V FDYQ + DEL + G+++ + K ED GWWEG+ GRRG+FPDNFV
Sbjct: 77 VLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLPPPPIKKLV 136
Query: 56 IKKEMKKDPLTNKAPEK--PLHEVPSGNSLLSSET 88
+K + ++ K P+K P +P+ L ++ T
Sbjct: 137 PRKVVSRESAPIKEPKKLMPKTSLPTVKKLATATT 171
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.130 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,763,684
Number of Sequences: 37866
Number of extensions: 1735161
Number of successful extensions: 15856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 928
Number of HSP's that attempted gapping in prelim test: 11094
Number of HSP's gapped (non-prelim): 4631
length of query: 665
length of database: 18,247,518
effective HSP length: 109
effective length of query: 556
effective length of database: 14,120,124
effective search space: 7850788944
effective search space used: 7850788944
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.