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Search of human proteins with 7662320
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662320 leucine-rich repeats and immunoglobulin-like domains
2 [Homo sapiens]
(1065 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 2150 0.0
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 1137 0.0
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 1113 0.0
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 903 0.0
gi|109150416 peroxidasin [Homo sapiens] 204 4e-52
gi|126517478 peroxidasin homolog-like [Homo sapiens] 199 2e-50
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 155 2e-37
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 152 2e-36
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 147 5e-35
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 147 5e-35
gi|198041768 synleurin [Homo sapiens] 142 2e-33
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 141 4e-33
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 140 5e-33
gi|4759146 slit homolog 2 [Homo sapiens] 137 7e-32
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 137 7e-32
gi|225579152 insulin-like growth factor binding protein, acid la... 136 1e-31
gi|4826772 insulin-like growth factor binding protein, acid labi... 136 1e-31
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 135 2e-31
gi|19743806 roundabout 1 isoform b [Homo sapiens] 135 3e-31
gi|4506569 roundabout 1 isoform a [Homo sapiens] 135 3e-31
gi|118572606 hemicentin 1 [Homo sapiens] 133 1e-30
gi|51317373 netrin-G1 ligand [Homo sapiens] 132 1e-30
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 130 7e-30
gi|224994173 roundabout 1 isoform d [Homo sapiens] 129 1e-29
gi|224994171 roundabout 1 isoform c [Homo sapiens] 129 1e-29
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 129 1e-29
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 129 1e-29
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 128 3e-29
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 128 3e-29
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 128 3e-29
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 2150 bits (5570), Expect = 0.0
Identities = 1065/1065 (100%), Positives = 1065/1065 (100%)
Query: 1 MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRK 60
MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRK
Sbjct: 1 MAPAPLGVPEEQLLGCRSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRK 60
Query: 61 LPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTS 120
LPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTS
Sbjct: 61 LPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTS 120
Query: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRIT 180
NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRIT
Sbjct: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRIT 180
Query: 181 TLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDS 240
TLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDS
Sbjct: 181 TLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDS 240
Query: 241 LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIE 300
LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIE
Sbjct: 241 LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIE 300
Query: 301 RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN 360
RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN
Sbjct: 301 RISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSN 360
Query: 361 LQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNN 420
LQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNN
Sbjct: 361 LQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNN 420
Query: 421 AIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQ 480
AIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQ
Sbjct: 421 AIMSIQENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQ 480
Query: 481 SILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEIL 540
SILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEIL
Sbjct: 481 SILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEIL 540
Query: 541 YDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNE 600
YDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNE
Sbjct: 541 YDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNE 600
Query: 601 MPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVF 660
MPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVF
Sbjct: 601 MPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVF 660
Query: 661 FIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAG 720
FIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAG
Sbjct: 661 FIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAG 720
Query: 721 GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY 780
GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY
Sbjct: 721 GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY 780
Query: 781 LNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSI 840
LNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSI
Sbjct: 781 LNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSI 840
Query: 841 TNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRV 900
TNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRV
Sbjct: 841 TNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRV 900
Query: 901 ICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESL 960
ICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESL
Sbjct: 901 ICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHPPQDTTALESL 960
Query: 961 IPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESP 1020
IPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESP
Sbjct: 961 IPSANREPSAFPTNHERISEKKLPSTQMSGETLQRPVWNINRELGLPHPPFSQQPVHESP 1020
Query: 1021 QLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT 1065
QLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT
Sbjct: 1021 QLHQNEGLAGREPDCSASSMSCHRLQDHAFDFSRTRNIQDGSEGT 1065
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 1137 bits (2941), Expect = 0.0
Identities = 585/945 (61%), Positives = 724/945 (76%), Gaps = 28/945 (2%)
Query: 43 CPAPCSCRIPLLDCSRRKL-----PAPSWRALSGLLPPDTAILDFSHNRLSNWNISLES- 96
CP C C LLDCSR++L P PSW A LD SHNRLS S S
Sbjct: 47 CPTTCRCLGDLLDCSRKRLARLPEPLPSW----------VARLDLSHNRLSFIKASSMSH 96
Query: 97 -QTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNI 155
Q+L+EVK+N NEL IP G ++NITLLSL N I EI + L+ + +LE+LDLSSN
Sbjct: 97 LQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNN 156
Query: 156 ISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
ISE++T+ FP +QLKYL L++NR+T++E G FDNL+++LLV+KLNRNR+S IPPK+FKLP
Sbjct: 157 ISELQTA-FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLP 215
Query: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275
LQ LEL RN+IK V+GLTFQGL +L+SLKMQRNG++KL DGAF+GL+NME L+L+HNNL
Sbjct: 216 QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNL 275
Query: 276 TRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLS 335
T + KGWLYGL MLQ+L++SQNAI RISPDAWEFCQ+LSELDL++N L+RLD+S+F+GLS
Sbjct: 276 TEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLS 335
Query: 336 LLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQG 395
LL L++G+NRV++IAD FR LS+L+TLDL+NNEISW IED + AF+GL L +LILQG
Sbjct: 336 LLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQG 395
Query: 396 NQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLLCDCHLKWL 454
N+I+SITKKAF GL++LEHLDL++NAIMS+Q NAFSQ L++L LNTSSLLCDC LKWL
Sbjct: 396 NRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL 455
Query: 455 LQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
QW+ +NNFQ VN SCAHP+ L G+SI V FVCDDF KPQI PET A++G N
Sbjct: 456 PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSN 515
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
++ C+A SSSDSPM+ W+KD+E+L+D + EN+ Q GE +EYT+IL L V F
Sbjct: 516 LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFAS 575
Query: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQIS 634
EGKYQC+++NHFGS+YS KAKLTVN +PSF KTPMDLTIR GAMARLECAA GHPAPQI+
Sbjct: 576 EGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIA 635
Query: 635 WQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLE 694
WQKDGGTDFPAARERRMHVMPEDDVFFI +VKIED+G+YSC AQN+AG +SANA+LTVLE
Sbjct: 636 WQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLE 695
Query: 695 TPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIV 754
TPSF+RPL D+TVT+GETAVLQCIAGGSP P+LNWTKDD PL+VTERHFFAA NQLLIIV
Sbjct: 696 TPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIV 755
Query: 755 DAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQ-SSIGHEDDGWTTVGIVIIVV 813
D+ + DAGKYTC MSNTLGTERG++ L+VI +P CDS Q ++ +DDGW TVG+VII V
Sbjct: 756 DSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAV 815
Query: 814 VCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSE 873
VCCVVGTSL+WV++IYH RR+NED SITNT+E NLPADIPSYLSSQGTL++ Q+GY +SE
Sbjct: 816 VCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSE 875
Query: 874 AGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTREY-CPYTYIAEEDVLDQ 932
+GSH Q + + +GT I D A++ + T + CP+ L
Sbjct: 876 SGSHHQFVTSSGAGFFLPQHDSSGTCHI--DNSSEADVEAATDLFLCPFLGSTGPMYLK- 932
Query: 933 TLSSLMVQMPKETYLV--HPPQDTTALESLIPSANREPSAFPTNH 975
++ P ETY P T ++ PS ++ +P +H
Sbjct: 933 --GNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 975
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 1113 bits (2880), Expect = 0.0
Identities = 568/902 (62%), Positives = 705/902 (78%), Gaps = 13/902 (1%)
Query: 81 DFSHNRLSNWNISLES--QTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQ 138
D SHNRLS S S Q+L+EVK+N NEL IP G ++NITLLSL N I EI +
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
Query: 139 ALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198
L+ + +LE+LDLSSN ISE++T+ FP +QLKYL L++NR+T++E G FDNL+++LLV+K
Sbjct: 80 HLKEFQSLETLDLSSNNISELQTA-FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138
Query: 199 LNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGA 258
LNRNR+S IPPK+FKLP LQ LEL RN+IK V+GLTFQGL +L+SLKMQRNG++KL DGA
Sbjct: 139 LNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGA 198
Query: 259 FFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL 318
F+GL+NME L+L+HNNLT + KGWLYGL MLQ+L++SQNAI RISPDAWEFCQ+LSELDL
Sbjct: 199 FWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDL 258
Query: 319 SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDA 378
++N L+RLD+S+F+GLSLL L++G+NRV++IAD FR LS+L+TLDL+NNEISW IED
Sbjct: 259 TFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM 318
Query: 379 SEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKE 437
+ AF+GL L +LILQGN+I+SITKKAF GL++LEHLDL++NAIMS+Q NAFSQ L++
Sbjct: 319 NGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQ 378
Query: 438 LILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLK 497
L LNTSSLLCDC LKWL QW+ +NNFQ VN SCAHP+ L G+SI V FVCDDF K
Sbjct: 379 LHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPK 438
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
PQI PET A++G N++ C+A SSSDSPM+ W+KD+E+L+D + EN+ Q GE
Sbjct: 439 PQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGE 498
Query: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGA 617
+EYT+IL L V F EGKYQC+++NHFGS+YS KAKLTVN +PSF KTPMDLTIR GA
Sbjct: 499 VMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGA 558
Query: 618 MARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMA 677
MARLECAA GHPAPQI+WQKDGGTDFPAARERRMHVMPEDDVFFI +VKIED+G+YSC A
Sbjct: 559 MARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTA 618
Query: 678 QNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737
QN+AG +SANA+LTVLETPSF+RPL D+TVT+GETAVLQCIAGGSP P+LNWTKDD PL+
Sbjct: 619 QNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLV 678
Query: 738 VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQ-SSI 796
VTERHFFAA NQLLIIVD+ + DAGKYTC MSNTLGTERG++ L+VI +P CDS Q ++
Sbjct: 679 VTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAP 738
Query: 797 GHEDDGWTTVGIVIIVVVCCVVGTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYL 856
+DDGW TVG+VII VVCCVVGTSL+WV++IYH RR+NED SITNT+E NLPADIPSYL
Sbjct: 739 SLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYL 798
Query: 857 SSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGTDGGTGTRVICSDCYDNANIYSRTR 916
SSQGTL++ Q+GY +SE+GSH Q + + +GT I D A++ + T
Sbjct: 799 SSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHI--DNSSEADVEAATD 856
Query: 917 EY-CPYTYIAEEDVLDQTLSSLMVQMPKETYLV--HPPQDTTALESLIPSANREPSAFPT 973
+ CP+ L ++ P ETY P T ++ PS ++ +P
Sbjct: 857 LFLCPFLGSTGPMYLK---GNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPC 913
Query: 974 NH 975
+H
Sbjct: 914 SH 915
Score = 122 bits (305), Expect = 2e-27
Identities = 146/646 (22%), Positives = 246/646 (38%), Gaps = 95/646 (14%)
Query: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK-------------------- 255
H+ +L NR+ ++ + L SLR +K+ N + +
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIV 74
Query: 256 -------------DGAFFGLNNMEELE------------LEHNNLTRVNKGWLYGL-RML 289
+ NN+ EL+ L N +T + G+ L L
Sbjct: 75 EILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTL 134
Query: 290 QQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTH 349
L +++N I I P ++ Q L L+L+ N++ +D F GL L+ L + N VT
Sbjct: 135 LVLKLNRNRISAIPPKMFKLPQ-LQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK 193
Query: 350 IADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGL 409
+ DG F LSN++ L L +N ++ E GL L +L L N I I+ A+
Sbjct: 194 LMDGAFWGLSNMEILQLDHNNLT---EITKGWLYGLLMLQELHLSQNAINRISPDAWEFC 250
Query: 410 ESLEHLDLNNNAIMSIQENAF---SQTHLKELILNTSSLLCDCHLKWL------------ 454
+ L LDL N + + +++F S + + N S + DC + L
Sbjct: 251 QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNE 310
Query: 455 LQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
+ W +++ + L G I ++ K F D L+ + I++L+G
Sbjct: 311 ISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE-HLDLSDNAIMSLQG-- 367
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
S + + S +L D + ++ W + + +
Sbjct: 368 ------NAFSQMKKLQQLHLNTSSLLCDCQLK-WLPQWVAENNFQSFVN-ASCAHPQLLK 419
Query: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQ-I 633
+ + F + K ++TV + I+ ++ + AA +P
Sbjct: 420 GRSIFAVSPDGFVCDDFPKPQITV-------QPETQSAIKGSNLSFICSAASSSDSPMTF 472
Query: 634 SWQKDGGTDFPAARERRMH-------VMPEDDVFFIANVKIEDMGIYSCMAQNTAG-GLS 685
+W+KD A E H VM + + V+ G Y C+ N G S
Sbjct: 473 AWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYS 532
Query: 686 ANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDG---PLLVTERH 742
A LTV PSF + D T+ G A L+C A G PAP++ W KD G P R
Sbjct: 533 VKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRM 592
Query: 743 FFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPN 788
+ + IVD +ED G Y+C N+ G+ + L V+ +P+
Sbjct: 593 HVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS 638
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 903 bits (2333), Expect = 0.0
Identities = 500/1003 (49%), Positives = 637/1003 (63%), Gaps = 79/1003 (7%)
Query: 43 CPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNIS--LESQTLQ 100
C A C+C LDC R L A L G LP T L+ S+N+LS + + + LQ
Sbjct: 41 CAAACTCAGDSLDCGGRGLAA-----LPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQ 95
Query: 101 EVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIK 160
EV +N NELT +P G +S++ L L HN I + L+ Y +LE LDLS N I+E++
Sbjct: 96 EVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVR 155
Query: 161 TSSFPR-MQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQF 219
+ FP +K LNL+ NRI TLE G FD LS SLL ++L++NR++ +P + FKLP L
Sbjct: 156 NTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQ 215
Query: 220 LELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVN 279
L+L RNRI+++EGLTFQGL+SL LK+QRN ISKL DGAF+GL+ M L LE+N+L VN
Sbjct: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
Query: 280 KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLER 339
G LYGL L QL++S N+I RI W FCQ+L EL LS+N LTRLDE + LS L
Sbjct: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
Query: 340 LNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIK 399
L L N ++HIA+G F+ L +L+ LDL +NEIS IED S AF+GL SL+KL L GN+IK
Sbjct: 336 LRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIK 395
Query: 400 SITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWL 458
S+ K+AF GLE LEHL+L NAI S+Q +AF +LKEL +++ S LCDC LKWL WL
Sbjct: 396 SVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWL 455
Query: 459 VDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLT 518
+ Q V +CAHPE L GQSI +V + FVCDDFLKPQI T PET +A+ G ++ T
Sbjct: 456 IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKPQIITQPETTMAMVGKDIRFT 515
Query: 519 CTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKY 578
C+A SSS SPM+ W+KD+E+L + D ENFV Q GE +EYT+ILHL V F EG+Y
Sbjct: 516 CSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILHLRQVTFGHEGRY 575
Query: 579 QCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKD 638
QC++TNHFGS YS KA+LTVN +PSF KTP D+TIRT MARLECAA GHP PQI+WQKD
Sbjct: 576 QCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAATGHPNPQIAWQKD 635
Query: 639 GGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSF 698
GGTDFPAARERRMHVMP+DDVFFI +VKI+D G+YSC AQN+AG +SANA+LTVLETPS
Sbjct: 636 GGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAGSISANATLTVLETPSL 695
Query: 699 IRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGL 758
+ PLED+ V+ GET LQC A G+P PR+ W K D PL +TERH NQLL++ +
Sbjct: 696 VVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTPDNQLLVVQNVVA 755
Query: 759 EDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVV 818
EDAG+YTC MSNTLGTER H L+V+ + C DG TTVGI I VV +V
Sbjct: 756 EDAGRYTCEMSNTLGTERAHSQLSVLPAAGC---------RKDG-TTVGIFTIAVVSSIV 805
Query: 819 GTSLIWVIVIYHMRRKNEDYSITNTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQ 878
TSL+WV +IY R+K+E+YS+TNT+E +P D+PSYLSSQGTLS+ QE +E G
Sbjct: 806 LTSLVWVCIIYQTRKKSEEYSVTNTDETVVPPDVPSYLSSQGTLSDRQETVVRTEGG--- 862
Query: 879 QLMPPANGYI----------------------------------HK----------GTDG 894
P ANG+I HK GT G
Sbjct: 863 ---PQANGHIESNGVCPRDASHFPEPDTHSVACRQPKLCAGSAYHKEPWKAMEKAEGTPG 919
Query: 895 ----GTGTRVICSDCYDNANIYSRTREYCPYTYIAEEDVLDQTLSSLMVQMPKETYLVHP 950
G RV+CSDC + YSR + + P + S+ P + H
Sbjct: 920 PHKMEHGGRVVCSDCNTEVDCYSRGQAFHPQPVSRD----SAQPSAPNGPEPGGSDQEHS 975
Query: 951 PQDTTALESLIPSANREPSAFPTNHERI--SEKKLPSTQMSGE 991
P + + + S +P+NH+R+ + KK P + G+
Sbjct: 976 PHHQCSRTAAGSCPECQGSLYPSNHDRMLTAVKKKPMASLDGK 1018
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 204 bits (519), Expect = 4e-52
Identities = 148/479 (30%), Positives = 227/479 (47%), Gaps = 33/479 (6%)
Query: 314 SELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISW 373
S LDL +N++ + AF L L L L +N++ I G F L NL+ L L NEI
Sbjct: 65 SILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQ- 123
Query: 374 AIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT 433
+I+ +AF GL SL +L L NQI+++ +F L LE L L+NN I + F+
Sbjct: 124 SID--RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHL 181
Query: 434 H-LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVS----CAHPEWLAGQSILNVDLK 488
+K L L++++L CDC + WL L + S N C +P + G+S+ + +
Sbjct: 182 ESMKRLRLDSNTLHCDCEILWLADLL--KTYAESGNAQAAAICEYPRRIQGRSVATITPE 239
Query: 489 DFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVW-RKDSEILYDVDTEN 547
+ C+ +P+I + P+ G V TC A + + +W R ++E+ D+
Sbjct: 240 ELNCE---RPRITSEPQDADVTSGNTVYFTCRAEGNPKPEI--IWLRNNNELSMKTDSRL 294
Query: 548 FVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTV---NEMPSF 604
L L + N TD+G YQC+ N G +Q+ L P+F
Sbjct: 295 ----------NLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
Query: 605 LKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIAN 664
+ P + + G LEC+A GHP P+ISW + T P + R+++ P ++ I N
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPV--DPRVNITPSGGLY-IQN 401
Query: 665 VKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPA 724
V D G Y+C A N + A A + V P F +D+ V G+T QC A G+P
Sbjct: 402 VVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPP 461
Query: 725 PRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
P + WTK L V RH ++ L I L D G+Y C N +G+++ +L V
Sbjct: 462 PVIAWTKGGSQLSVDRRHLVLSSGTLR-ISGVALHDQGQYECQAVNIIGSQKVVAHLTV 519
Score = 177 bits (450), Expect = 4e-44
Identities = 159/566 (28%), Positives = 245/566 (43%), Gaps = 47/566 (8%)
Query: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
L ++ N I +++ GAF L N+ L L +N + R+ G L L+ LY+ +N I+ I
Sbjct: 67 LDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSID 126
Query: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
A++ L +L L +NQ+ LD +F L LERL L +NR+TH+ G F L +++
Sbjct: 127 RQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKR 186
Query: 364 LDLRNN------EISWAIE------DASEAFAGLTSLTKLILQGNQIKSITKKAFIGLE- 410
L L +N EI W + ++ A A +QG + +IT + + E
Sbjct: 187 LRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEE-LNCER 245
Query: 411 ---SLEHLDLNNNAIMSIQENAFSQTHLKELIL-----NTSSLLCDCHLKWLLQW--LVD 460
+ E D + + ++ ++ + K I+ N S+ D L L ++
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQ 305
Query: 461 NNFQHSVNVSCAHPEWLAGQ-SILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTC 519
N + + + +AG+ V L+ F +P P+ L G +VTL C
Sbjct: 306 NTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSP--ARPTFVIQPQNTEVLVGESVTLEC 363
Query: 520 TAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQ 579
+A + P W + VD V G L++ NV D G+Y
Sbjct: 364 SA--TGHPPPRISWTRGDRTPLPVDPR--VNITPSGG--------LYIQNVVQGDSGEYA 411
Query: 580 CIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG 639
C TN+ S ++ A + V +P F TP D + G +C A+G+P P I+W K G
Sbjct: 412 CSATNNIDSVHAT-AFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK-G 469
Query: 640 GTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLE--TPS 697
G+ R H++ I+ V + D G Y C A N G A LTV TP
Sbjct: 470 GSQLSVDRR---HLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPV 526
Query: 698 FIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAG 757
F D TV G L C + G P P + W KD G + F + L I D G
Sbjct: 527 FASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKD-GVQVTESGKFHISPEGFLTINDVG 585
Query: 758 LEDAGKYTCIMSNTLGTERGHIYLNV 783
DAG+Y C+ NT+G+ + L+V
Sbjct: 586 PADAGRYECVARNTIGSASVSMVLSV 611
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/155 (32%), Positives = 82/155 (52%), Gaps = 7/155 (4%)
Query: 123 TLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITT 181
T + +H ++ + A A P LDL N I EI+ +F R++ L L L+NN+I
Sbjct: 45 TTVRCMHLLLEAVPAVA----PQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKR 100
Query: 182 LEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDS 240
+ +G F++L + L + L +N + I + FK L L+ L L N+I+ ++ +FQ L
Sbjct: 101 IPSGAFEDLEN-LKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPK 159
Query: 241 LRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275
L L + N I+ L G F L +M+ L L+ N L
Sbjct: 160 LERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTL 194
Score = 62.0 bits (149), Expect = 3e-09
Identities = 55/180 (30%), Positives = 80/180 (44%), Gaps = 10/180 (5%)
Query: 17 RSRVLSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPD 76
R +L+ +LF A L ++ CP+ C C + C L A + P
Sbjct: 10 RRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVP------AVAPQ 63
Query: 77 TAILDFSHNRLSNWNISL--ESQTLQEVKMNYNELTEIPYFG-EPTSNITLLSLVHNIIP 133
T+ILD NR+ + L + +N N++ IP E N+ L L N I
Sbjct: 64 TSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQ 123
Query: 134 EINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSS 192
I+ QA + +LE L L N I + SF + +L+ L L NNRIT L G F++L S
Sbjct: 124 SIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLES 183
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 199 bits (505), Expect = 2e-50
Identities = 145/480 (30%), Positives = 230/480 (47%), Gaps = 31/480 (6%)
Query: 311 QRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNE 370
Q+ + LDL +N++ + SAF L L L L +N + I+ F L NL L L NE
Sbjct: 50 QQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
Query: 371 ISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430
I A++ + F GL SL L + NQ++ + + F L LE L L+NN + I +F
Sbjct: 110 IH-ALD--KQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSF 166
Query: 431 SQTH-LKELILNTSSLLCDCHLKWLLQWLVDNNFQHS---VNVSCAHPEWLAGQSILNVD 486
S LK L L++++L+CDC L WL + L+ QH +C +P L G+++ +V
Sbjct: 167 SNLDSLKRLRLDSNALVCDCDLMWLGE-LLQGFAQHGHTQAAATCEYPRRLHGRAVASVT 225
Query: 487 LKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTE 546
+++F C P+I P+ + G V TC A + + +W ++ L D++ +
Sbjct: 226 VEEFNCQS---PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEI--IWIHNNHSL-DLEDD 279
Query: 547 NFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMP---S 603
+ + L + N +D+G YQC+ N G +Q A L + +P S
Sbjct: 280 TRLNVFDDG--------TLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPS 331
Query: 604 FLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIA 663
F+ P D + G LEC A GHP P I+W +D G + +R HV ++ +
Sbjct: 332 FVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSR----HVATSSGLY-LQ 386
Query: 664 NVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSP 723
N+ D G ++C A N+ G + A A++ V P F +D+ V C A G+P
Sbjct: 387 NITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNP 446
Query: 724 APRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
P + WTK G L V +H ++ L I A D G+Y C ++LG ++ + L V
Sbjct: 447 PPVIVWTKTGGQLPVEGQHTVLSSGTLR-IDRAAQHDQGQYECQAVSSLGVKKVSVQLTV 505
Score = 99.4 bits (246), Expect = 2e-20
Identities = 78/289 (26%), Positives = 115/289 (39%), Gaps = 22/289 (7%)
Query: 497 KPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAG 556
KP P+ L G + TL C A + P+ T W +D+ + D
Sbjct: 329 KPSFVIQPQDTEVLIGTSTTLECMA-TGHPHPLIT-WTRDNGLELD------------GS 374
Query: 557 EALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTG 616
+ +S L+L N+ D G++ C N G+ A + V P F TP D +
Sbjct: 375 RHVATSSGLYLQNITQRDHGRFTCHANNSHGT-VQAAANIIVQAPPQFTVTPKDQVVLEE 433
Query: 617 AMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCM 676
C A+G+P P I W K GG P + H + I D G Y C
Sbjct: 434 HAVEWLCEADGNPPPVIVWTKTGG-QLPVEGQ---HTVLSSGTLRIDRAAQHDQGQYECQ 489
Query: 677 AQNTAGGLSANASLTVLETPS--FIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDG 734
A ++ G + LTV F + +D +V G+ + C A G P P + W K+ G
Sbjct: 490 AVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKE-G 548
Query: 735 PLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
+ F L I DAG D G+Y C+ N+ G +++L V
Sbjct: 549 VQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 94.7 bits (234), Expect = 4e-19
Identities = 60/202 (29%), Positives = 99/202 (49%), Gaps = 12/202 (5%)
Query: 594 AKLTVNEM----PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARER 649
A +TV E P P D+ + +G C AEG+P P+I W + + +
Sbjct: 222 ASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS-LDLEDDT 280
Query: 650 RMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASL----TVLETPSFIRPLEDK 705
R++V +D I N + D G+Y CMA+N+AG +++ ++ PSF+ +D
Sbjct: 281 RLNVF-DDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDT 339
Query: 706 TVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYT 765
V G + L+C+A G P P + WT+D+G L RH A + L + + D G++T
Sbjct: 340 EVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRH--VATSSGLYLQNITQRDHGRFT 397
Query: 766 CIMSNTLGTERGHIYLNVISSP 787
C +N+ GT + + V + P
Sbjct: 398 CHANNSHGTVQAAANIIVQAPP 419
Score = 87.4 bits (215), Expect = 6e-17
Identities = 132/568 (23%), Positives = 214/568 (37%), Gaps = 64/568 (11%)
Query: 168 QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNR 226
Q L+L NRI + F L + L + LN N + I F+ L +L +L L +N
Sbjct: 51 QTTVLDLRFNRIREIPGSAFKKLKN-LNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNE 109
Query: 227 IKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGL 286
I ++ TF+GL SL L + N + L+ F L +E L L +N L+++ G L
Sbjct: 110 IHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNL 169
Query: 287 RMLQQLYVSQNAIERISPDAW--EFCQRLSELDLSYNQLT-----RLDESAFVGLSLLER 339
L++L + NA+ W E Q ++ + T RL A +++ E
Sbjct: 170 DSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTV-EE 228
Query: 340 LNLGDNRVTHIADGVFRFLSNLQTLDLRNN-----EISWAIEDASEAFAGLTSLTKLILQ 394
N R+T V N R EI W + S T L +
Sbjct: 229 FNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLN-VFDD 287
Query: 395 GNQIKSITKKAFIGL----------ESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSS 444
G + T+++ G+ E+ + + + + + Q E+++ TS+
Sbjct: 288 GTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTST 347
Query: 445 LLCDC----HLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDF----- 495
L +C H L+ W DN + + A L Q+I D F C
Sbjct: 348 TL-ECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGT 406
Query: 496 ----------LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDT 545
PQ P+ + L V C A + P VW K L V+
Sbjct: 407 VQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEA--DGNPPPVIVWTKTGGQL-PVEG 463
Query: 546 ENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFG-SNYSQKAKLTVNEMPSF 604
++ V + L + D+G+Y+C + G S + + + F
Sbjct: 464 QHTVLS----------SGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVF 513
Query: 605 LKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIAN 664
+ P D ++ G + C A+G P P I+W K+G + HV ++ I +
Sbjct: 514 TQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEG---VQITESGKFHV-DDEGTLTIYD 569
Query: 665 VKIEDMGIYSCMAQNTAGGLSANASLTV 692
D G Y C+A+N+ G N LTV
Sbjct: 570 AGFPDQGRYECVARNSFGLAVTNMFLTV 597
Score = 60.5 bits (145), Expect = 8e-09
Identities = 47/158 (29%), Positives = 83/158 (52%), Gaps = 10/158 (6%)
Query: 120 SNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNR 178
S + + L+ + IP++ Q LDL N I EI S+F +++ L L L+NN
Sbjct: 33 STVRCMHLMLDHIPQVPQQTTV-------LDLRFNRIREIPGSAFKKLKNLNTLLLNNNH 85
Query: 179 ITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQG 237
I + F+ L + LL + L +N + + + FK L L+ L + N++++++ TF
Sbjct: 86 IRKISRNAFEGLEN-LLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGD 144
Query: 238 LDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275
L L L + N +SK+ G+F L++++ L L+ N L
Sbjct: 145 LLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNAL 182
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 155 bits (391), Expect = 2e-37
Identities = 130/467 (27%), Positives = 216/467 (46%), Gaps = 35/467 (7%)
Query: 30 TALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSN 89
T+LLLL A A CP C C + + CS +L +PP T + F
Sbjct: 10 TSLLLL-ARPAQPCPMGCDCFVQEVFCSDEELATVPLD-----IPPYTKNIIF------- 56
Query: 90 WNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESL 149
V+ ++ L + P N+T + ++ + + A P LE L
Sbjct: 57 ------------VETSFTTLETRAFGSNP--NLTKVVFLNTQLCQFRPDAFGGLPRLEDL 102
Query: 150 DLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIP 208
+++ + + T+ F + L L L+ N + L G F +L++ L + L N++ +P
Sbjct: 103 EVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAA-LESLHLQGNQLQALP 161
Query: 209 PKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEE 267
++F+ L HL+ L L +N + + F L SL++LK+ N +S L G F L +++E
Sbjct: 162 RRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQE 221
Query: 268 LELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLD 327
L L+ NN++ + L L++L++ +NAI + + L+ L L +N L L
Sbjct: 222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLP 281
Query: 328 ESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTS 387
F L L+L N++ +A+G F LSNL++L L N I+ + F L
Sbjct: 282 AGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL---PAGIFRDLEE 338
Query: 388 LTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLL 446
L KL L N + ++ F L LE L L+ N + ++ E F + L L L+ +
Sbjct: 339 LVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQ 398
Query: 447 CDCHLKWLLQWLVD-NNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC 492
CDCHL +L WL + ++ CA P +L GQ + ++ K VC
Sbjct: 399 CDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 152 bits (383), Expect = 2e-36
Identities = 175/610 (28%), Positives = 261/610 (42%), Gaps = 109/610 (17%)
Query: 25 LFIAQTALLLLPAAG--AGLCPAPCSCRIPL--LDCSRRKLPAPSWRALSGLLPPDTAIL 80
L + LLLLPAA AG CPA C C + + C+RR+L TA+
Sbjct: 5 LCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRL---------------TAVP 49
Query: 81 DFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQAL 140
D G P LL L N I +N L
Sbjct: 50 D----------------------------------GIPAET-RLLELSRNRIRCLNPGDL 74
Query: 141 QFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLN 200
PALE LDLS N I+ + E G F NL L V++L
Sbjct: 75 AALPALEELDLSENAIAHV-----------------------EPGAFANL-PRLRVLRLR 110
Query: 201 RNRMSMIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAF 259
N++ +IPP +F +L +L L+L N++ I+ TFQ L SLR L++ N + + AF
Sbjct: 111 GNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAF 170
Query: 260 FGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL- 318
GL +EEL LE NLT ++ L LR L L + AI + + L L++
Sbjct: 171 AGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEID 230
Query: 319 SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDA 378
++ L + + GL+L L++ +T + R ++L L+L +N IS
Sbjct: 231 NWPLLEEVAAGSLRGLNLTS-LSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTV---P 286
Query: 379 SEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKE 437
+F L L +L L G + + +AF+GL + L+L+NN + +++E+ F S L+
Sbjct: 287 RGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLET 346
Query: 438 LILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILN----VDLKDFVCD 493
L ++ + L CDC L W++Q NF + +CA P + G ++ N V + FVC
Sbjct: 347 LRVDGNPLACDCRLLWIVQRRKTLNFDGRL-PACATPAEVRGDALRNLPDSVLFEYFVC- 404
Query: 494 DFLKPQIRTHP-ETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFVRY 551
KP+IR + + A G +V C A P TV W V ++
Sbjct: 405 --RKPKIRERRLQRVTATAGEDVRFLCRA---EGEPAPTVAW---------VTPQHRPVT 450
Query: 552 WQQAGEALEYT-SILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMD 610
AG A L + + D G Y C+ +N G N + A LTV P+ +TP +
Sbjct: 451 ATSAGRARVLPGGTLEIQDARPQDSGTYTCVASN-AGGNDTYFATLTVRPEPAANRTPGE 509
Query: 611 LTIRTGAMAR 620
T A R
Sbjct: 510 AHNETLAALR 519
Score = 48.5 bits (114), Expect = 3e-05
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 1/87 (1%)
Query: 611 LTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDM 670
+T G R C AEG PAP ++W A R V+P I + + +D
Sbjct: 417 VTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLP-GGTLEIQDARPQDS 475
Query: 671 GIYSCMAQNTAGGLSANASLTVLETPS 697
G Y+C+A N G + A+LTV P+
Sbjct: 476 GTYTCVASNAGGNDTYFATLTVRPEPA 502
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/102 (31%), Positives = 42/102 (41%), Gaps = 2/102 (1%)
Query: 700 RPLEDKTVTRGETAVLQCIAGGSPAPRLNW-TKDDGPLLVTER-HFFAAANQLLIIVDAG 757
R L+ T T GE C A G PAP + W T P+ T L I DA
Sbjct: 412 RRLQRVTATAGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAGRARVLPGGTLEIQDAR 471
Query: 758 LEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHE 799
+D+G YTC+ SN G + L V P + + +E
Sbjct: 472 PQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPGEAHNE 513
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 147 bits (371), Expect = 5e-35
Identities = 143/518 (27%), Positives = 234/518 (45%), Gaps = 80/518 (15%)
Query: 32 LLLL---PAAGAGL----CPAPCSC-RIPLLDCSRRKL---PAP-SWRALSGLLPPDTAI 79
LLLL A GAGL CP+ C+C R ++C+ ++ P P W A+S
Sbjct: 13 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMS--------- 63
Query: 80 LDFSHNRLSNWNIS--LESQTLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEIN 136
L + ++ N S L L +++ NEL+ I P ++ LSL +N + +
Sbjct: 64 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 123
Query: 137 AQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLL 195
Q +LESL LSSN + +I+ + F + LK L L N + + G FD+L L
Sbjct: 124 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-LT 182
Query: 196 VVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK 255
+ L +N ++ I P++F Q L +L+ L++ N ++ +
Sbjct: 183 KLNLGKNSLTHISPRVF-----------------------QHLGNLQVLRLYENRLTDIP 219
Query: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
G F GL N++EL L+ N + ++ G + LQ+LY+S N I ++ P + +L+
Sbjct: 220 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNR 279
Query: 316 LDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAI 375
L L N L L F + L L L DN ++ + D VF L LQ L L N+IS+
Sbjct: 280 LTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI- 338
Query: 376 EDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH- 434
+ AF GLT L +L L N ++ + F L +L+++ L NN + + N F+ +
Sbjct: 339 --SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNG 396
Query: 435 ------------------------LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNV- 469
L EL L + CD + L WL+ N + +
Sbjct: 397 LMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV 456
Query: 470 -SCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPET 506
C P + GQS++ +++ V + P++ ++PET
Sbjct: 457 PVCFSPANVRGQSLIIINVNVAVPSVHV-PEVPSYPET 493
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 147 bits (371), Expect = 5e-35
Identities = 143/518 (27%), Positives = 234/518 (45%), Gaps = 80/518 (15%)
Query: 32 LLLL---PAAGAGL----CPAPCSC-RIPLLDCSRRKL---PAP-SWRALSGLLPPDTAI 79
LLLL A GAGL CP+ C+C R ++C+ ++ P P W A+S
Sbjct: 7 LLLLVGCQAWGAGLAYHGCPSECTCSRASQVECTGARIVAVPTPLPWNAMS--------- 57
Query: 80 LDFSHNRLSNWNIS--LESQTLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEIN 136
L + ++ N S L L +++ NEL+ I P ++ LSL +N + +
Sbjct: 58 LQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLP 117
Query: 137 AQALQFYPALESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLL 195
Q +LESL LSSN + +I+ + F + LK L L N + + G FD+L L
Sbjct: 118 IGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVG-LT 176
Query: 196 VVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK 255
+ L +N ++ I P++F Q L +L+ L++ N ++ +
Sbjct: 177 KLNLGKNSLTHISPRVF-----------------------QHLGNLQVLRLYENRLTDIP 213
Query: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
G F GL N++EL L+ N + ++ G + LQ+LY+S N I ++ P + +L+
Sbjct: 214 MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNR 273
Query: 316 LDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAI 375
L L N L L F + L L L DN ++ + D VF L LQ L L N+IS+
Sbjct: 274 LTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFI- 332
Query: 376 EDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH- 434
+ AF GLT L +L L N ++ + F L +L+++ L NN + + N F+ +
Sbjct: 333 --SPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNG 390
Query: 435 ------------------------LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNV- 469
L EL L + CD + L WL+ N + +
Sbjct: 391 LMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTV 450
Query: 470 -SCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPET 506
C P + GQS++ +++ V + P++ ++PET
Sbjct: 451 PVCFSPANVRGQSLIIINVNVAVPSVHV-PEVPSYPET 487
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 142 bits (358), Expect = 2e-33
Identities = 120/439 (27%), Positives = 205/439 (46%), Gaps = 49/439 (11%)
Query: 163 SFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLEL 222
+FP + +L L+ N I+ + L S + + N N + + P +L HL FL L
Sbjct: 57 NFPESTV-FLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFL 115
Query: 223 KRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGW 282
N IK ++ F+GL +LR+L +Q N +S + G F L +++ L L+ N LT + G
Sbjct: 116 NNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGT 175
Query: 283 LYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNL 342
G+ L+ L +S N I RIS ++ + L+ L L N LT++ +AF L L RL+L
Sbjct: 176 FVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSL 235
Query: 343 GDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSIT 402
N + I F+ L+NL+ L L+N+ I D F+G+ +L LIL N ++++
Sbjct: 236 SHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRD---GFSGINNLKHLILSHNDLENLN 292
Query: 403 KKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILN----------------TSSLL 446
F L++L +L L+ N I+SI + F ILN SSL+
Sbjct: 293 SDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLI 352
Query: 447 ----------CDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDF- 495
C+C L L WL + ++N+ C +P + G+++ +++ + V
Sbjct: 353 HLQANSNPWECNCKLLGLRDWLASSAI--TLNIYCQNPPSMRGRALRYINITNCVTSSIN 410
Query: 496 -------LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENF 548
+K H T + + VT + + ++++ T W + + T
Sbjct: 411 VSRAWAVVKSPHIHHKTTALMMAWHKVTTNGSPLENTETENITFWER-------IPTSPA 463
Query: 549 VRYWQQ--AGEALEYTSIL 565
R++Q+ G LE T++L
Sbjct: 464 GRFFQENAFGNPLETTAVL 482
Score = 79.3 bits (194), Expect = 2e-14
Identities = 70/251 (27%), Positives = 112/251 (44%), Gaps = 29/251 (11%)
Query: 99 LQEVKMNYNELTEIP--YFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
L+ + + YN+++ +P F + S + L+L N + + + AL LDLS+N I
Sbjct: 134 LRNLYLQYNQVSFVPRGVFNDLVS-VQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNI 192
Query: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
I S F ++ L L L +N +T + + F+ L S
Sbjct: 193 LRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKS----------------------- 229
Query: 216 HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNL 275
L+ L L N I+ ++ F+GL +L L ++ + I + F G+NN++ L L HN+L
Sbjct: 230 -LRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDL 288
Query: 276 TRVNKGWLYGLRMLQQLYVSQNAIERISPDAWE-FCQRLSELDLSYNQLTRLDESAFVGL 334
+N L+ L L + +N I I D +E L L+LS+N LT L L
Sbjct: 289 ENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPL 348
Query: 335 SLLERLNLGDN 345
S L L N
Sbjct: 349 SSLIHLQANSN 359
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 141 bits (355), Expect = 4e-33
Identities = 125/390 (32%), Positives = 184/390 (47%), Gaps = 32/390 (8%)
Query: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
++L L+ N I+++ TF+ L L L++ +N + K++ GAF GL ++ LEL N LT
Sbjct: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
Query: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL-SYNQLTRLDESAFVGLSL 336
V L L++L++ N IE I A+ L LDL +L + E+AF GL
Sbjct: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
Query: 337 LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN 396
L LNLG + I + L L+ L+L N + I S F GLTSL KL L
Sbjct: 209 LRYLNLGMCNLKDIPN--LTALVRLEELELSGNRLD-LIRPGS--FQGLTSLRKLWLMHA 263
Query: 397 QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLLCDCHLKWLL 455
Q+ +I + AF L+SLE L+L++N +MS+ + F+ H L+ + LN + C+C + WL
Sbjct: 264 QVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLS 323
Query: 456 QWLVDNNFQHSVNVS-CAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
WL + ++ + C P L G+ I +D F C P I P + GM
Sbjct: 324 WWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMA 380
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFT- 573
L C + S S W + L G S+LH +NFT
Sbjct: 381 AELKC---RTGTSMTSVNWLTPNGTL------------MTHGSYRVRISVLHDGTLNFTN 425
Query: 574 ----DEGKYQCIVTNHFGSNYSQKAKLTVN 599
D G+Y C+VTN G N + A L V+
Sbjct: 426 VTVQDTGQYTCMVTNSAG-NTTASATLNVS 454
Score = 80.1 bits (196), Expect = 1e-14
Identities = 76/275 (27%), Positives = 125/275 (45%), Gaps = 23/275 (8%)
Query: 37 AAGAGL-----CPAPCSC--RIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHN---- 85
AAG G CP CSC + + C+RR L + +P +T L+ N
Sbjct: 46 AAGGGSPPATSCPVACSCSNQASRVICTRRDLAE-----VPASIPVNTRYLNLQENGIQV 100
Query: 86 -RLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYP 144
R + + LQ K ++ + G P+ N L L N + + QA ++
Sbjct: 101 IRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNT--LELFDNRLTTVPTQAFEYLS 158
Query: 145 ALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN-NRITTLEAGCFDNLSSSLLVVKLNRN 202
L L L +N I I + +F R+ L+ L+L R+ + F+ L + L + L
Sbjct: 159 KLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-LRYLNLGMC 217
Query: 203 RMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGL 262
+ IP + L L+ LEL NR+ ++ +FQGL SLR L + ++ ++ AF L
Sbjct: 218 NLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDL 276
Query: 263 NNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQN 297
++EEL L HNNL + L L++++++ N
Sbjct: 277 KSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
Score = 50.4 bits (119), Expect = 9e-06
Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFF 661
P ++ P DL + G A L+C G ++W GT R + D
Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
Query: 662 IANVKIEDMGIYSCMAQNTAGGLSANASLTV 692
NV ++D G Y+CM N+AG +A+A+L V
Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
Score = 42.0 bits (97), Expect = 0.003
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 696 PSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAA---NQLLI 752
P + P D VT G A L+C G S +NW +G L+ + + + L
Sbjct: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
Query: 753 IVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
+ ++D G+YTC+++N+ G LNV
Sbjct: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 140 bits (354), Expect = 5e-33
Identities = 126/410 (30%), Positives = 203/410 (49%), Gaps = 26/410 (6%)
Query: 36 PAAGAGLCPAPCSCR----IPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWN 91
P G CPAPC C+ + DCS L A + G L P TA LD S N L+
Sbjct: 28 PGPGPTACPAPCHCQEDGIMLSADCSELGLSA-----VPGDLDPLTAYLDLSMNNLTELQ 82
Query: 92 ISL--ESQTLQEVKMNYNELTEIPYFGEPTS---NITLLSLVHNIIPEINAQALQFYPAL 146
L + L+E++++ N L+ IP G+ S ++ +L L +N + I A+AL P+L
Sbjct: 83 PGLFHHLRFLEELRLSGNHLSHIP--GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSL 140
Query: 147 ESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
+SL L +N+IS + SF + L++L L +N +T + +NL + L + L NR+S
Sbjct: 141 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA-LQAMTLALNRIS 199
Query: 206 MIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN 264
IP F+ L L L L NRI+ + +F+GL +L +L + N + + A L
Sbjct: 200 HIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV-AIRTLGR 258
Query: 265 MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLT 324
++EL +NN+ + + G +LQ ++ N I+ + A+++ +L L L+ +
Sbjct: 259 LQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN-GAMD 317
Query: 325 RLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAG 384
+ G + LE L L + + G+ + L L+ L+L +N+I + +
Sbjct: 318 IQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI-----EELPSLHR 372
Query: 385 LTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH 434
L ++ LQ N+I I F L SL+ LDL+ NAI SI AFS H
Sbjct: 373 CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 422
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/260 (28%), Positives = 118/260 (45%), Gaps = 6/260 (2%)
Query: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLD 239
T A C +L + +S +P + P +L+L N + ++ F L
Sbjct: 33 TACPAPCHCQEDGIMLSADCSELGLSAVPGDLD--PLTAYLDLSMNNLTELQPGLFHHLR 90
Query: 240 SLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAI 299
L L++ N +S + AF GL +++ L L++N L + L+ L LQ L + N I
Sbjct: 91 FLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLI 150
Query: 300 ERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLS 359
+ ++E L L L N LT + A L L+ + L NR++HI D F+ L+
Sbjct: 151 SLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLT 210
Query: 360 NLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNN 419
+L L L NN I + +F GL +L L L N+++ A L L+ L +N
Sbjct: 211 SLVVLHLHNNRIQHL---GTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHN 266
Query: 420 NAIMSIQENAFSQTHLKELI 439
N I +I E AF L + I
Sbjct: 267 NNIKAIPEKAFMGNPLLQTI 286
Score = 85.5 bits (210), Expect = 2e-16
Identities = 70/210 (33%), Positives = 103/210 (49%), Gaps = 6/210 (2%)
Query: 238 LDSLRS-LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQ 296
LD L + L + N +++L+ G F L +EEL L N+L+ + GL L+ L +
Sbjct: 64 LDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQN 123
Query: 297 NAIERISPDA-WEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVF 355
N + I +A WE L L L N ++ + E +F GLS L L L DN +T I
Sbjct: 124 NQLGGIPAEALWEL-PSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRAL 182
Query: 356 RFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHL 415
L LQ + L N IS + AF LTSL L L N+I+ + +F GL +LE L
Sbjct: 183 NNLPALQAMTLALNRISHIPD---YAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETL 239
Query: 416 DLNNNAIMSIQENAFSQTHLKELILNTSSL 445
DLN N + + L+EL + +++
Sbjct: 240 DLNYNKLQEFPVAIRTLGRLQELGFHNNNI 269
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 137 bits (344), Expect = 7e-32
Identities = 118/426 (27%), Positives = 183/426 (42%), Gaps = 85/426 (19%)
Query: 147 ESLDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
E LDL+ N I+ I + F ++ L+ L L N+I+T+E G F +L L ++LNRN +
Sbjct: 58 ERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDL-KELERLRLNRNHLQ 116
Query: 206 MIPPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN 264
+ P +F L L+L N+I+ + F+G +++L++ N IS ++DGAF L +
Sbjct: 117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRD 176
Query: 265 MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIE------------RISPDAWEFCQR 312
+E L L +NN+TR++ + L+ + N + R P + Q
Sbjct: 177 LEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQC 236
Query: 313 LSELDLSYNQLTRLDESAFV-------------------------------GLSLLE--- 338
+ L + + + + FV G L E
Sbjct: 237 MGPSHLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPT 296
Query: 339 -------RLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKL 391
+ L N + I G F L+ +DL NN+IS E A +AF GL SL L
Sbjct: 297 NLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQIS---ELAPDAFQGLRSLNSL 353
Query: 392 ILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH----------------- 434
+L GN+I + K F GL SL+ L LN N I ++ +AF H
Sbjct: 354 VLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAK 413
Query: 435 --------LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVD 486
++ + L + +CDCHLKWL +L N + S C P LA + I +
Sbjct: 414 GTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETS-GARCTSPRRLANKRIGQIK 472
Query: 487 LKDFVC 492
K F C
Sbjct: 473 SKKFRC 478
Score = 124 bits (310), Expect = 6e-28
Identities = 112/376 (29%), Positives = 183/376 (48%), Gaps = 38/376 (10%)
Query: 149 LDLSSNIISEIK-TSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSM 206
L L++N + ++ T F ++ QL+ +N SNN+IT +E G F+ +S + + L NR+
Sbjct: 538 LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEG-ASGVNEILLTSNRLEN 596
Query: 207 IPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNM 265
+ K+FK L L+ L L+ NRI V +F GL S+R L + N I+ + GAF L+++
Sbjct: 597 VQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSL 656
Query: 266 EELELEHN----NLTRVNKG-WLYGLRM------------LQQLYVSQNAIERISPDAWE 308
L L N N G WL R+ L+++ + AI+ + D
Sbjct: 657 STLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGN 716
Query: 309 FCQRLSELDLSYNQLTRLD---ESAFVGLSLLER--------LNLGDNRVTHIADGVFRF 357
S L + T LD + GL +L + L L N+ T + + +
Sbjct: 717 DDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNY 776
Query: 358 LSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDL 417
+L +DL NN IS ++++F+ +T L LIL N+++ I + F GL+SL L L
Sbjct: 777 -KHLTLIDLSNNRISTL---SNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSL 832
Query: 418 NNNAIMSIQENAFSQ-THLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEW 476
+ N I + E AF+ + L L + + L CDC+++WL W V + ++ CA P
Sbjct: 833 HGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDW-VKSEYKEPGIARCAGPGE 891
Query: 477 LAGQSILNVDLKDFVC 492
+A + +L K F C
Sbjct: 892 MADKLLLTTPSKKFTC 907
Score = 105 bits (261), Expect = 3e-22
Identities = 73/230 (31%), Positives = 104/230 (45%), Gaps = 29/230 (12%)
Query: 264 NMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQL 323
N E L+L NN+TR+ K GLR L+ L + +N I I A++ + L L L+ N L
Sbjct: 56 NTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHL 115
Query: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFA 383
E F+G + L RL+L +N++ I FR
Sbjct: 116 QLFPELLFLGTAKLYRLDLSENQIQAIPRKAFR--------------------------- 148
Query: 384 GLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFS-QTHLKELILNT 442
G + L L NQI I AF L LE L LNNN I + +F+ L+ L++
Sbjct: 149 GAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHS 208
Query: 443 SSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC 492
++L CDCHL WL WL + + C P L G ++ V ++FVC
Sbjct: 209 NNLYCDCHLAWLSDWLRQRP-RVGLYTQCMGPSHLRGHNVAEVQKREFVC 257
Score = 103 bits (256), Expect = 1e-21
Identities = 116/481 (24%), Positives = 202/481 (41%), Gaps = 50/481 (10%)
Query: 34 LLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNIS 93
+ P+ CPA C+C ++DC + L + LP + N +
Sbjct: 264 MAPSCSVLHCPAACTCSNNIVDCRGKGLTE-----IPTNLPETITEIRLEQNTIKVIPPG 318
Query: 94 LES--QTLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLD 150
S + L+ + ++ N+++E+ P + ++ L L N I E+ + +L+ L
Sbjct: 319 AFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLL 378
Query: 151 LSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRM--SMI 207
L++N I+ ++ +F + L L+L +N++ T+ G F L + + + L +N
Sbjct: 379 LNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA-IQTMHLAQNPFICDCH 437
Query: 208 PPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGI------------SKLK 255
+ H +E R L + + ++S K + + SKL
Sbjct: 438 LKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLS 497
Query: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
F L E+ E + N+ N I P Q +E
Sbjct: 498 GDCFADLACPEKCRCEGTTVDCSNQ--------------KLNKIPEHIP------QYTAE 537
Query: 316 LDLSYNQLTRLDESA-FVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWA 374
L L+ N+ T L+ + F L L ++N +N++T I +G F S + + L +N +
Sbjct: 538 LRLNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLE-- 595
Query: 375 IEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH 434
+ F GL SL L+L+ N+I + +FIGL S+ L L +N I ++ AF H
Sbjct: 596 -NVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLH 654
Query: 435 -LKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCD 493
L L L + C+C+L WL +WL + N C P +L I +V ++DF CD
Sbjct: 655 SLSTLNLLANPFNCNCYLAWLGEWLRKKRIV-TGNPRCQKPYFLKEIPIQDVAIQDFTCD 713
Query: 494 D 494
D
Sbjct: 714 D 714
Score = 40.8 bits (94), Expect = 0.007
Identities = 29/74 (39%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
Query: 140 LQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198
L Y L +DLS+N IS + SF M QL L LS NR+ + FD L SL ++
Sbjct: 773 LSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGL-KSLRLLS 831
Query: 199 LNRNRMSMIPPKIF 212
L+ N +S++P F
Sbjct: 832 LHGNDISVVPEGAF 845
Score = 39.7 bits (91), Expect = 0.015
Identities = 36/151 (23%), Positives = 67/151 (44%), Gaps = 28/151 (18%)
Query: 43 CPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEV 102
CP C+C ++ CS + L + L +P D + E+
Sbjct: 727 CPTECTCLDTVVRCSNKGL-----KVLPKGIPRD----------------------VTEL 759
Query: 103 KMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTS 162
++ N+ T +P ++TL+ L +N I ++ Q+ L +L LS N + I
Sbjct: 760 YLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPR 819
Query: 163 SFPRMQ-LKYLNLSNNRITTLEAGCFDNLSS 192
+F ++ L+ L+L N I+ + G F++LS+
Sbjct: 820 TFDGLKSLRLLSLHGNDISVVPEGAFNDLSA 850
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 137 bits (344), Expect = 7e-32
Identities = 141/502 (28%), Positives = 226/502 (45%), Gaps = 56/502 (11%)
Query: 124 LLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLE 183
+L L N + +N + YP LE +DLS NII+ + E
Sbjct: 61 ILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANV-----------------------E 97
Query: 184 AGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLR 242
G F+NL + L ++L NR+ ++P +F L +L L++ N+I I+ FQ L +L+
Sbjct: 98 PGAFNNLFN-LRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLK 156
Query: 243 SLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERI 302
SL++ N + + AF GL ++E+L LE NLT V L LR L L++ I +
Sbjct: 157 SLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNM 216
Query: 303 SPDAWEFCQRLSELDLSY-NQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNL 361
A++ L L++ Y L + ++ GL+L L++ + ++ + F+ L L
Sbjct: 217 PVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTS-LSVTNTNLSTVPFLAFKHLVYL 275
Query: 362 QTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNA 421
L+L N IS IE + F+ L L +L + G Q+++I +F GL L L+++ N
Sbjct: 276 THLNLSYNPIS-TIE--AGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNL 332
Query: 422 IMSIQENAFSQTHLKELI-LNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQ 480
+ +++EN FS E++ +N + L CDC L W+LQ F CA P+ + +
Sbjct: 333 LETLEENVFSSPRALEVLSINNNPLACDCRLLWILQRQPTLQF-GGQQPMCAGPDTIRER 391
Query: 481 SILNVDLKD----FVCDDFLKPQIRTHP-ETIIALRGMNVTLTCTAVSSSDSPMSTVWRK 535
S + F C KP+IR + ++ G V L C+A +S V
Sbjct: 392 SFKDFHSTALSFYFTCK---KPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISWV--- 445
Query: 536 DSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAK 595
F+ + L + D G Y CI +N G N + A
Sbjct: 446 -------TPRRRFITTKSNGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAG-NDTFTAS 497
Query: 596 LTVNEMPS--FL---KTPMDLT 612
LTV S FL +TPM +T
Sbjct: 498 LTVKGFASDRFLYANRTPMYMT 519
Score = 84.3 bits (207), Expect = 5e-16
Identities = 123/518 (23%), Positives = 206/518 (39%), Gaps = 80/518 (15%)
Query: 197 VKLNRNRMSMIPPKIFKLP-HLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLK 255
V +R R+ IP I P + L+L +NR+K V F L + + N I+ ++
Sbjct: 41 VSCHRRRLIAIPEGI---PIETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVE 97
Query: 256 DGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSE 315
GAF L N+ L L+ N L V G GL L++
Sbjct: 98 PGAFNNLFNLRSLRLKGNRLKLVPLGVFTGL------------------------SNLTK 133
Query: 316 LDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAI 375
LD+S N++ L + F L L+ L +GDN + +I+ F L +L+ L L ++
Sbjct: 134 LDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAV- 192
Query: 376 EDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNN---------NAIMSIQ 426
+EA + L SL L L+ I ++ AF L L+HL+++ N++ +
Sbjct: 193 --PTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLN 250
Query: 427 ENAFSQTHLKELILNTSSLLCDCHLKWLLQWLVDNN---------FQHSVNVSCAHPEWL 477
+ S T+ L+T L HL +L + N F + + H +
Sbjct: 251 LTSLSVTNTN---LSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELH---I 304
Query: 478 AGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAV---SSSDSPMSTVWR 534
G + ++ F FL+ + + ++ NV + A+ S +++P++
Sbjct: 305 VGAQLRTIEPHSFQGLRFLR--VLNVSQNLLETLEENVFSSPRALEVLSINNNPLAC--- 359
Query: 535 KDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKA 594
D +L+ + + +++ Q +I +F S Y
Sbjct: 360 -DCRLLWILQRQPTLQFGGQQPMCAGPDTIRERSFKDFHSTAL----------SFYFTCK 408
Query: 595 KLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVM 654
K + E K L + G +LEC+A+G P P ISW R V+
Sbjct: 409 KPKIRE-----KKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVL 463
Query: 655 PEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTV 692
D I + +D G+Y C+A N AG + ASLTV
Sbjct: 464 -GDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
Score = 75.9 bits (185), Expect = 2e-13
Identities = 93/354 (26%), Positives = 154/354 (43%), Gaps = 44/354 (12%)
Query: 26 FIAQTALLLLPAAGAGLCPAPCSCRIP--LLDCSRRKLPAPSWRALSGLLPPDTAILDFS 83
F+ +L+ + G CPA C C + C RR+L A + +P +T ILD S
Sbjct: 12 FLGLAVVLIFMGSTIG-CPARCECSAQNKSVSCHRRRLIA-----IPEGIPIETKILDLS 65
Query: 84 HNRLSNWN------------ISLESQ--------------TLQEVKMNYNELTEIPYFGE 117
NRL + N I L L+ +++ N L +P G
Sbjct: 66 KNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVP-LGV 124
Query: 118 PT--SNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNL 174
T SN+T L + N I + Q L+SL++ N + I +F + L+ L L
Sbjct: 125 FTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTL 184
Query: 175 SNNRITTLEAGCFDNLSS--SLLVVKLNRNRMSMIPPKIFKLPHLQFLELKR-NRIKIVE 231
+T + +L S SL + LN N M + K +L HL+ LE+ + ++
Sbjct: 185 EKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFK--RLFHLKHLEIDYWPLLDMMP 242
Query: 232 GLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQ 291
+ GL+ L SL + +S + AF L + L L +N ++ + G L LQ+
Sbjct: 243 ANSLYGLN-LTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQE 301
Query: 292 LYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDN 345
L++ + I P +++ + L L++S N L L+E+ F LE L++ +N
Sbjct: 302 LHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNN 355
Score = 40.4 bits (93), Expect = 0.009
Identities = 24/78 (30%), Positives = 37/78 (47%), Gaps = 2/78 (2%)
Query: 700 RPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAA--ANQLLIIVDAG 757
+ L+ V G+T L+C A G P P ++W + T+ + A + L I A
Sbjct: 415 KKLQHLLVDEGQTVQLECSADGDPQPVISWVTPRRRFITTKSNGRATVLGDGTLEIRFAQ 474
Query: 758 LEDAGKYTCIMSNTLGTE 775
+D+G Y CI SN G +
Sbjct: 475 DQDSGMYVCIASNAAGND 492
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 136 bits (342), Expect = 1e-31
Identities = 104/328 (31%), Positives = 163/328 (49%), Gaps = 7/328 (2%)
Query: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179
N+ L L N + + PAL SL LS+N +S ++ F + L LNL N +
Sbjct: 161 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 220
Query: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGL 238
L F L S L + L NR++ + P +F L L+ L+L RN ++ ++ F L
Sbjct: 221 AVLPDAAFRGLGS-LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 279
Query: 239 DSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA 298
L+ L + RN I+ + GAF GL + L+L HN + + + GL L+ L +S NA
Sbjct: 280 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 339
Query: 299 IERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358
I + P ++ L EL L +N++ +L E +F GL LE L L N++ + G F L
Sbjct: 340 IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL 399
Query: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418
+N+ ++L N + E + F GL L L L+G+ + I F GL L L L
Sbjct: 400 TNVAVMNLSGNCLRNLPE---QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 456
Query: 419 NNAIMSIQENA-FSQTHLKELILNTSSL 445
+N ++ I+E + + L EL L ++ L
Sbjct: 457 DNGLVGIEEQSLWGLAELLELDLTSNQL 484
Score = 129 bits (324), Expect = 1e-29
Identities = 111/414 (26%), Positives = 194/414 (46%), Gaps = 34/414 (8%)
Query: 98 TLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
+L+E+ + N L + P + + L L N + I A P L+ L L N+I
Sbjct: 233 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 292
Query: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
+ + +F ++ L++L+LS+NR+ L F L L V++L+ N ++ + P+ FK
Sbjct: 293 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG-LRVLRLSHNAIASLRPRTFKDL 351
Query: 216 H-LQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274
H L+ L+L NRI+ + +F+GL L L + N + ++K GAF GL N+ + L N
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411
Query: 275 LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGL 334
L + + GL L L++ + + RI P + L L L N L ++E + GL
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 471
Query: 335 SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQ 394
+ L L+L N++TH+ +F+ L L+ L L N ++ E ++A L L +
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA---ELPADALGPLQRAFWLDVS 528
Query: 395 GNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWL 454
N+++++ L L +L L NN++ + L+ L L + C C LK L
Sbjct: 529 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGNPWDCGCPLKAL 585
Query: 455 LQWLVDN-----NFQHSV--------------NVSCAHPEWLAGQSILNVDLKD 489
+ + N F ++ N++CA P ++ +DL+D
Sbjct: 586 RDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP-----PEVVGLDLRD 634
Score = 121 bits (304), Expect = 3e-27
Identities = 83/257 (32%), Positives = 129/257 (50%), Gaps = 3/257 (1%)
Query: 174 LSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGL 233
L N ++++ F NLSS + S+ P + L +L L L+RN+++ +
Sbjct: 119 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 178
Query: 234 TFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLY 293
TF +L SL + N +S+L+DG F GL ++ +L L N+L + GL L++L
Sbjct: 179 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 238
Query: 294 VSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADG 353
++ N + + P + L ELDLS N L + + FV L L++L L N + +A G
Sbjct: 239 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 298
Query: 354 VFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLE 413
F L L+ LDL +N ++ +ED F GL L L L N I S+ + F L LE
Sbjct: 299 AFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 355
Query: 414 HLDLNNNAIMSIQENAF 430
L L +N I + E +F
Sbjct: 356 ELQLGHNRIRQLAERSF 372
Score = 104 bits (260), Expect = 4e-22
Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 3/213 (1%)
Query: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
Q L L N + V FQ L SL L +Q + L+ A GL N+ L LE N L
Sbjct: 115 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 174
Query: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLL 337
+ G L L +S N + R+ +E L +L+L +N L L ++AF GL L
Sbjct: 175 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 234
Query: 338 ERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQ 397
L L NR+ ++ +F L+ L+ LDL N + AI+ + F L L KL L N
Sbjct: 235 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALR-AIK--ANVFVQLPRLQKLYLDRNL 291
Query: 398 IKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430
I ++ AF+GL++L LDL++N + + E+ F
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF 324
Score = 45.1 bits (105), Expect = 4e-04
Identities = 33/87 (37%), Positives = 47/87 (54%), Gaps = 6/87 (6%)
Query: 347 VTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAF 406
+T + DGV Q L L N +S ++ A AF L+SL L LQG Q+ S+ +A
Sbjct: 103 LTRLPDGV---PGGTQALWLDGNNLS-SVPPA--AFQNLSSLGFLNLQGGQLGSLEPQAL 156
Query: 407 IGLESLEHLDLNNNAIMSIQENAFSQT 433
+GLE+L HL L N + S+ F+ T
Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHT 183
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 136 bits (342), Expect = 1e-31
Identities = 104/328 (31%), Positives = 163/328 (49%), Gaps = 7/328 (2%)
Query: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179
N+ L L N + + PAL SL LS+N +S ++ F + L LNL N +
Sbjct: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
Query: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGL 238
L F L S L + L NR++ + P +F L L+ L+L RN ++ ++ F L
Sbjct: 183 AVLPDAAFRGLGS-LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 241
Query: 239 DSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA 298
L+ L + RN I+ + GAF GL + L+L HN + + + GL L+ L +S NA
Sbjct: 242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 301
Query: 299 IERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358
I + P ++ L EL L +N++ +L E +F GL LE L L N++ + G F L
Sbjct: 302 IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL 361
Query: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418
+N+ ++L N + E + F GL L L L+G+ + I F GL L L L
Sbjct: 362 TNVAVMNLSGNCLRNLPE---QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 418
Query: 419 NNAIMSIQENA-FSQTHLKELILNTSSL 445
+N ++ I+E + + L EL L ++ L
Sbjct: 419 DNGLVGIEEQSLWGLAELLELDLTSNQL 446
Score = 129 bits (324), Expect = 1e-29
Identities = 111/414 (26%), Positives = 194/414 (46%), Gaps = 34/414 (8%)
Query: 98 TLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
+L+E+ + N L + P + + L L N + I A P L+ L L N+I
Sbjct: 195 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 254
Query: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
+ + +F ++ L++L+LS+NR+ L F L L V++L+ N ++ + P+ FK
Sbjct: 255 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG-LRVLRLSHNAIASLRPRTFKDL 313
Query: 216 H-LQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274
H L+ L+L NRI+ + +F+GL L L + N + ++K GAF GL N+ + L N
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373
Query: 275 LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGL 334
L + + GL L L++ + + RI P + L L L N L ++E + GL
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
Query: 335 SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQ 394
+ L L+L N++TH+ +F+ L L+ L L N ++ E ++A L L +
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA---ELPADALGPLQRAFWLDVS 490
Query: 395 GNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWL 454
N+++++ L L +L L NN++ + L+ L L + C C LK L
Sbjct: 491 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGNPWDCGCPLKAL 547
Query: 455 LQWLVDN-----NFQHSV--------------NVSCAHPEWLAGQSILNVDLKD 489
+ + N F ++ N++CA P ++ +DL+D
Sbjct: 548 RDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP-----PEVVGLDLRD 596
Score = 121 bits (304), Expect = 3e-27
Identities = 83/257 (32%), Positives = 129/257 (50%), Gaps = 3/257 (1%)
Query: 174 LSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGL 233
L N ++++ F NLSS + S+ P + L +L L L+RN+++ +
Sbjct: 81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
Query: 234 TFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLY 293
TF +L SL + N +S+L+DG F GL ++ +L L N+L + GL L++L
Sbjct: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 200
Query: 294 VSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADG 353
++ N + + P + L ELDLS N L + + FV L L++L L N + +A G
Sbjct: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 260
Query: 354 VFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLE 413
F L L+ LDL +N ++ +ED F GL L L L N I S+ + F L LE
Sbjct: 261 AFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 317
Query: 414 HLDLNNNAIMSIQENAF 430
L L +N I + E +F
Sbjct: 318 ELQLGHNRIRQLAERSF 334
Score = 104 bits (260), Expect = 4e-22
Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 3/213 (1%)
Query: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
Q L L N + V FQ L SL L +Q + L+ A GL N+ L LE N L
Sbjct: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
Query: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLL 337
+ G L L +S N + R+ +E L +L+L +N L L ++AF GL L
Sbjct: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
Query: 338 ERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQ 397
L L NR+ ++ +F L+ L+ LDL N + AI+ + F L L KL L N
Sbjct: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALR-AIK--ANVFVQLPRLQKLYLDRNL 253
Query: 398 IKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430
I ++ AF+GL++L LDL++N + + E+ F
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF 286
Score = 45.1 bits (105), Expect = 4e-04
Identities = 33/87 (37%), Positives = 47/87 (54%), Gaps = 6/87 (6%)
Query: 347 VTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAF 406
+T + DGV Q L L N +S ++ A AF L+SL L LQG Q+ S+ +A
Sbjct: 65 LTRLPDGV---PGGTQALWLDGNNLS-SVPPA--AFQNLSSLGFLNLQGGQLGSLEPQAL 118
Query: 407 IGLESLEHLDLNNNAIMSIQENAFSQT 433
+GLE+L HL L N + S+ F+ T
Sbjct: 119 LGLENLCHLHLERNQLRSLALGTFAHT 145
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 135 bits (340), Expect = 2e-31
Identities = 143/458 (31%), Positives = 218/458 (47%), Gaps = 42/458 (9%)
Query: 147 ESLDLSSNIISEIKTSSFPRMQL-KYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
E LDLS N + ++ R+ L + L+LS N+++TLE G F L SLL ++L NR+
Sbjct: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGL-QSLLTLRLQGNRLR 121
Query: 206 MIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNN 264
++ P +F L L L+L+ N+I + F L SL+ L++ N + + GAF GL
Sbjct: 122 IMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAK 181
Query: 265 MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLS-YNQL 323
+ L LE NL+ V L L L L + + I R+ A +L EL++ + L
Sbjct: 182 LSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSL 241
Query: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFA 383
LD + VGL+ L L + ++ + LS L+ LDL N IS AI + +
Sbjct: 242 EALDPGSLVGLN-LSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPIS-AI--PARRLS 297
Query: 384 GLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAF-SQTHLKELILNT 442
L L +L L G + SI AF GL + LD+ +NA+ +++E AF S L L L+
Sbjct: 298 PLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSG 357
Query: 443 SSLLCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFL------ 496
+ L CDC L WLL+ +F S +CA P + G+S LK+F D L
Sbjct: 358 NPLTCDCRLLWLLRLRRHLDFGMS-PPACAGPHHVQGKS-----LKEF--SDILPPGHFT 409
Query: 497 -KPQI--RTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFVRYW 552
KP + ++ P +IA G + +C S P TV W + +
Sbjct: 410 CKPALIRKSGPRWVIAEEGGHAVFSC---SGDGDPAPTVSWMRPHG-----------AWL 455
Query: 553 QQAGEA-LEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589
+AG + L + +V D G Y C+V+N G++
Sbjct: 456 GRAGRVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGND 493
Score = 107 bits (268), Expect = 5e-23
Identities = 106/349 (30%), Positives = 158/349 (45%), Gaps = 15/349 (4%)
Query: 32 LLLLPAAGAGLCPAPCSC--RIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSN 89
LLLLP G CPA C C + + C R+L A+ G LP DT +LD S NRL
Sbjct: 20 LLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQL-----EAVPGGLPLDTELLDLSGNRLWG 74
Query: 90 WNISLESQ--TLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPAL 146
+ S+ LQE+ ++YN+L+ + P ++ L L N + + AL
Sbjct: 75 LQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSAL 134
Query: 147 ESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMS 205
LDL N I +F + L+ L + +N + + G F L + L + L R +S
Sbjct: 135 TLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGL-AKLSTLTLERCNLS 193
Query: 206 MIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQR-NGISKLKDGAFFGLN 263
+P + +LP L L L+ I + +GL L+ L++ + L G+ GL
Sbjct: 194 TVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL- 252
Query: 264 NMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQL 323
N+ L + NL+ V LY L L+ L +SQN I I RL EL LS L
Sbjct: 253 NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACL 312
Query: 324 TRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS 372
T + AF GL+ L++ DN + + + F L TL L N ++
Sbjct: 313 TSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 50.1 bits (118), Expect = 1e-05
Identities = 30/93 (32%), Positives = 43/93 (46%), Gaps = 3/93 (3%)
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
G A C+ +G PAP +SW + G R R+ V+ ED I +V++ D G Y C
Sbjct: 428 GGHAVFSCSGDGDPAPTVSWMRPHGAWL--GRAGRVRVL-EDGTLEIRSVQLRDRGAYVC 484
Query: 676 MAQNTAGGLSANASLTVLETPSFIRPLEDKTVT 708
+ N AG S L V++ L D +T
Sbjct: 485 VVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNIT 517
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/105 (30%), Positives = 43/105 (40%), Gaps = 4/105 (3%)
Query: 696 PSFIRPLEDKTVT--RGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLII 753
P+ IR + V G AV C G PAP ++W + G L + L I
Sbjct: 412 PALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAGRVRVLEDGTLEI 471
Query: 754 VDAGLEDAGKYTCIMSNTLGTERGHIYLNVI--SSPNCDSSQSSI 796
L D G Y C++SN G + +L VI PN S +I
Sbjct: 472 RSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEPPNGTLSDPNI 516
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 135 bits (339), Expect = 3e-31
Identities = 89/295 (30%), Positives = 130/295 (44%), Gaps = 24/295 (8%)
Query: 496 LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
L+ R +P ++ G + C P + W+KD L D D +R +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGK-- 185
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
L + +D GKY C+ TN G S+ A+LTV E PSF+K P +L +
Sbjct: 186 ---------LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
A +C A G P P + W+KD G + P +R + + +D I V DMG Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 676 MAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGP 735
+A+N G A+A+LTV E P F+ D+ V G T QC A G+P P + W ++
Sbjct: 292 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 351
Query: 736 LLV-------TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
L+ + F + L I + D G Y C N G+ YL V
Sbjct: 352 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 406
Score = 121 bits (304), Expect = 3e-27
Identities = 94/301 (31%), Positives = 132/301 (43%), Gaps = 17/301 (5%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSE-ILYDVDTENFVR 550
+DF P+I HP +I +G TL C A P T+ W K E + D D R
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKA---EGRPTPTIEWYKGGERVETDKDDPRSHR 80
Query: 551 YWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM-PSFLKTPM 609
+G +L + I+H + DEG Y C+ N+ G S A L V + F + P
Sbjct: 81 MLLPSG-SLFFLRIVH-GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 610 DLTIRTGAMARLEC-AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIE 668
D+ + G A +EC GHP P ISW+KDG ++ + I +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKS 194
Query: 669 DMGIYSCMAQNTAGGLSAN-ASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
D G Y C+ N G + A LTVLE PSF++ + VT ++A +C A G P P +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
W KDDG L + + + L I D G YTC+ N +G L V P
Sbjct: 255 RWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
Query: 788 N 788
+
Sbjct: 313 H 313
Score = 107 bits (267), Expect = 6e-23
Identities = 76/231 (32%), Positives = 102/231 (44%), Gaps = 15/231 (6%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECA 624
L + V D G Y C+ N G + A LTV E P F+ P D + G +C
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 334
Query: 625 AEGHPAPQISWQKDGGTDF-----PAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQN 679
A G+P P I W+++G + P R V D+ I NV+ D+G Y C N
Sbjct: 335 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVGYYICQTLN 393
Query: 680 TAGGLSANASLTVLET-----PSFIR--PLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
AG + A L V + P IR P+ ++TV T VL C+A GSP P + W KD
Sbjct: 394 VAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVPTILWRKD 452
Query: 733 DGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
+ + N +L I A L D G+YTCI S G Y+ V
Sbjct: 453 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 503
Score = 60.5 bits (145), Expect = 8e-09
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P P + G VT C A + + WR++ ++N + +Q
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREG-------SQNLLFSYQPPQS 362
Query: 558 ALEY----TSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM------PSFLKT 607
+ + T L + NV +D G Y C N GS + KA L V ++ P +
Sbjct: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQG 421
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P++ T+ L C A G P P I W+KDG + ++ R+ + E+ V I K+
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKL 478
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP 701
D G Y+C+A +G + +A + V E ++P
Sbjct: 479 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 512
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 135 bits (339), Expect = 3e-31
Identities = 89/295 (30%), Positives = 130/295 (44%), Gaps = 24/295 (8%)
Query: 496 LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
L+ R +P ++ G + C P + W+KD L D D +R +
Sbjct: 168 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGK-- 224
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
L + +D GKY C+ TN G S+ A+LTV E PSF+K P +L +
Sbjct: 225 ---------LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
A +C A G P P + W+KD G + P +R + + +D I V DMG Y+C
Sbjct: 276 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 330
Query: 676 MAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGP 735
+A+N G A+A+LTV E P F+ D+ V G T QC A G+P P + W ++
Sbjct: 331 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
Query: 736 LLV-------TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
L+ + F + L I + D G Y C N G+ YL V
Sbjct: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 445
Score = 121 bits (304), Expect = 3e-27
Identities = 94/301 (31%), Positives = 132/301 (43%), Gaps = 17/301 (5%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSE-ILYDVDTENFVR 550
+DF P+I HP +I +G TL C A P T+ W K E + D D R
Sbjct: 64 EDF-PPRIVEHPSDLIVSKGEPATLNCKA---EGRPTPTIEWYKGGERVETDKDDPRSHR 119
Query: 551 YWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM-PSFLKTPM 609
+G +L + I+H + DEG Y C+ N+ G S A L V + F + P
Sbjct: 120 MLLPSG-SLFFLRIVH-GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
Query: 610 DLTIRTGAMARLEC-AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIE 668
D+ + G A +EC GHP P ISW+KDG ++ + I +
Sbjct: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKS 233
Query: 669 DMGIYSCMAQNTAGGLSAN-ASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
D G Y C+ N G + A LTVLE PSF++ + VT ++A +C A G P P +
Sbjct: 234 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV 293
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
W KDDG L + + + L I D G YTC+ N +G L V P
Sbjct: 294 RWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Query: 788 N 788
+
Sbjct: 352 H 352
Score = 107 bits (267), Expect = 6e-23
Identities = 76/231 (32%), Positives = 102/231 (44%), Gaps = 15/231 (6%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECA 624
L + V D G Y C+ N G + A LTV E P F+ P D + G +C
Sbjct: 315 LKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 373
Query: 625 AEGHPAPQISWQKDGGTDF-----PAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQN 679
A G+P P I W+++G + P R V D+ I NV+ D+G Y C N
Sbjct: 374 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVGYYICQTLN 432
Query: 680 TAGGLSANASLTVLET-----PSFIR--PLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
AG + A L V + P IR P+ ++TV T VL C+A GSP P + W KD
Sbjct: 433 VAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVPTILWRKD 491
Query: 733 DGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
+ + N +L I A L D G+YTCI S G Y+ V
Sbjct: 492 GVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 542
Score = 60.5 bits (145), Expect = 8e-09
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P P + G VT C A + + WR++ ++N + +Q
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREG-------SQNLLFSYQPPQS 401
Query: 558 ALEY----TSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM------PSFLKT 607
+ + T L + NV +D G Y C N GS + KA L V ++ P +
Sbjct: 402 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQG 460
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P++ T+ L C A G P P I W+KDG + ++ R+ + E+ V I K+
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKL 517
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP 701
D G Y+C+A +G + +A + V E ++P
Sbjct: 518 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 551
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 133 bits (334), Expect = 1e-30
Identities = 90/321 (28%), Positives = 143/321 (44%), Gaps = 24/321 (7%)
Query: 488 KDFVCDDFLKPQIR---THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVD 544
K++ +++P I +HP II RG +++L C P + W KD L
Sbjct: 2280 KEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEV--QGIPPPTVTWMKDGHPLIKA- 2336
Query: 545 TENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSF 604
+ E L+ IL L N++ +D G+Y C+ N G +K L+V+ PS
Sbjct: 2337 ---------KGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMT-DKKYDLSVHAPPSI 2386
Query: 605 L---KTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFF 661
+ ++P ++++ L C A G P P I+W KDG +P + + ++ +
Sbjct: 2387 IGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDG---WPVSLSNSVRILSGGRMLR 2443
Query: 662 IANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFI--RPLEDKTVTRGETAVLQCIA 719
+ +ED G Y+C+ +N AG L+VL P + LED V ++ L C
Sbjct: 2444 LMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEV 2503
Query: 720 GGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHI 779
G+P P + W KD PL E H + + L I + + G+YTC+ S+ G +
Sbjct: 2504 TGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSF 2563
Query: 780 YLNVISSPNCDSSQSSIGHED 800
LNV SP S ED
Sbjct: 2564 SLNVFVSPTIAGVGSDGNPED 2584
Score = 127 bits (319), Expect = 6e-29
Identities = 84/300 (28%), Positives = 136/300 (45%), Gaps = 14/300 (4%)
Query: 488 KDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTEN 547
++F+ + P I+ P++++ L + L C A +P T WRKD +L N
Sbjct: 3703 REFILTVNVPPNIKGGPQSLVILLNKSTVLECIA-EGVPTPRIT-WRKDGAVL----AGN 3756
Query: 548 FVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKT 607
RY ++ LH+ + + TD G+Y C+ TN G++ ++ L V+ PS
Sbjct: 3757 HARY------SILENGFLHIQSAHVTDTGRYLCMATNAAGTD-RRRIDLQVHVPPSIAPG 3809
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P ++T+ L C A G P P I+W+K+G + + + + I + +
Sbjct: 3810 PTNMTVIVNVQTTLACEATGIPKPSINWRKNGHL-LNVDQNQNSYRLLSSGSLVIISPSV 3868
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
+D Y C N AG LTV PS D VT+ AV+ C A G P P +
Sbjct: 3869 DDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSI 3928
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
+WTK+ LL + ++ + I+ L AG+YTC+ N G+ H+ L+V P
Sbjct: 3929 HWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP 3988
Score = 125 bits (314), Expect = 2e-28
Identities = 89/308 (28%), Positives = 140/308 (45%), Gaps = 34/308 (11%)
Query: 504 PETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTS 563
P + L G NV L C A + +P+ W KD + + +TE S
Sbjct: 3253 PSDVSVLLGENVELVCNA-NGIPTPLIQ-WLKDGKPIASGETERI--------RVSANGS 3302
Query: 564 ILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSF---------LKTPMDLTIR 614
L+++ +D GKY C+ TN G + L V P+ L T +D +I
Sbjct: 3303 TLNIYGALTSDTGKYTCVATNPAGEE-DRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSIN 3361
Query: 615 TGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYS 674
+EC A G P PQI+W K+G P + ++ V I ++ D+ +Y+
Sbjct: 3362 ------IECRATGTPPPQINWLKNG---LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYT 3412
Query: 675 CMAQNTAGGLSANASLTVLETPSFIRPL--EDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
C+A N AG + + +L V P+ + E+ TV +G + + CI G+PAP + W +D
Sbjct: 3413 CVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD 3472
Query: 733 DGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSS 792
PL + + +L ++ A ED+GKYTCI SN G H L V+ P+ + S
Sbjct: 3473 GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGS 3532
Query: 793 QSSIGHED 800
+ HE+
Sbjct: 3533 EE---HEE 3537
Score = 122 bits (306), Expect = 2e-27
Identities = 87/290 (30%), Positives = 130/290 (44%), Gaps = 16/290 (5%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P + P + G LTC +S+ D ++ W+++ DV R A
Sbjct: 520 PPVIQVPNNVTVTPGERAVLTCLIISAVDYNLT--WQRNDR---DVRLAEPARIRTLANL 574
Query: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGA 617
+LE S V F D G+Y C+V++ GS+ + LTV E P P + + G+
Sbjct: 575 SLELKS------VKFNDAGEYHCMVSSEGGSS-AASVFLTVQEPPKVTVMPKNQSFTGGS 627
Query: 618 MARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMA 677
+ C+A G+P P+I+W + + R R M D FI N +D GIY C+A
Sbjct: 628 EVSIMCSATGYPKPKIAWTVNDMFIVGSHRYR----MTSDGTLFIKNAAPKDAGIYGCLA 683
Query: 678 QNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737
N+AG N++L +E P + + V G+ V++C G P P++ W K D L
Sbjct: 684 SNSAGTDKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELR 743
Query: 738 VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
+ LL I + DAG YTC+ N G G I L+V S P
Sbjct: 744 PSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPP 793
Score = 122 bits (306), Expect = 2e-27
Identities = 105/355 (29%), Positives = 156/355 (43%), Gaps = 51/355 (14%)
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
+TL C A + + +S W KD + L D N A +T L + +D
Sbjct: 2692 LTLECEAYAIPSASLS--WYKDGQPLKSDDHVNIA--------ANGHT--LQIKEAQISD 2739
Query: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKT----PMDLTIRTGAMA--------RLE 622
G+Y C+ +N G + + + PSF K M T R G L
Sbjct: 2740 TGRYTCVASNIAGED-ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLY 2798
Query: 623 CAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
C P P ++W KDG P ++ ++P V I K+ED G Y+C+A N AG
Sbjct: 2799 CETNAAPPPTLTWYKDG---HPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG 2855
Query: 683 GLSANASLTVLETPSFIRPL-----EDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737
S + VL P I+ E+ TV ++A+++C++ GSPAPR +W KD PLL
Sbjct: 2856 EDSLQYDVRVL-VPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLL 2914
Query: 738 VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIG 797
+ H F + ++L I++ + D G+Y C+ NT G+ + + LNV P S IG
Sbjct: 2915 EDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPP------SVIG 2968
Query: 798 HEDDGWTTVGIVIIVVVCCVVG---TSLIWVIVIYHMRRKNEDYSITNTEELNLP 849
+ + T V I + C V G L W+ KNE NT L +P
Sbjct: 2969 PKSENLTVVVNNFISLTCEVSGFPPPDLSWL--------KNEQPIKLNTNTLIVP 3015
Score = 122 bits (305), Expect = 2e-27
Identities = 97/318 (30%), Positives = 145/318 (45%), Gaps = 22/318 (6%)
Query: 486 DLKDFVCDDFLKPQIR-THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVD 544
D K+F + ++ P I E I+ VTLTC A P + W K+ + + + D
Sbjct: 3139 DDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIP--PPTIAWLKNHKRIENSD 3196
Query: 545 TENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAK-LTVNEMPS 603
+ L S L + +D G Y CI +N G +QK L++ PS
Sbjct: 3197 SLEV--------RILSGGSKLQIARSQHSDSGNYTCIASNMEGK--AQKYYFLSIQVPPS 3246
Query: 604 F--LKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFF 661
+ P D+++ G L C A G P P I W KD G + R+ V
Sbjct: 3247 VAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKD-GKPIASGETERIRVSANGSTLN 3305
Query: 662 IANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLED---KTVTRGETAV-LQC 717
I D G Y+C+A N AG +L V TP+ IR +D K +T +T++ ++C
Sbjct: 3306 IYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPT-IRGNKDEAEKLMTLVDTSINIEC 3364
Query: 718 IAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERG 777
A G+P P++NW K+ PL ++ AA Q++ IV A + D YTC+ SN G +
Sbjct: 3365 RATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNK 3424
Query: 778 HIYLNVISSPNCDSSQSS 795
H L V + PN D+S +
Sbjct: 3425 HYNLQVFAPPNMDNSMGT 3442
Score = 112 bits (279), Expect = 2e-24
Identities = 74/248 (29%), Positives = 111/248 (44%), Gaps = 14/248 (5%)
Query: 564 ILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLK-----TPMDLTIRTGAM 618
+L + D G+Y C+ N G + Q + +P +K P ++T+
Sbjct: 2832 VLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL--VPPIIKGANSDLPEEVTVLVNKS 2889
Query: 619 ARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQ 678
A +EC + G PAP+ SWQKDG P + + + I N +I D+G Y C+A+
Sbjct: 2890 ALIECLSSGSPAPRNSWQKDGQ---PLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAE 2946
Query: 679 NTAGGLSANASLTVLETPSFIRPL-EDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737
NTAG +L V PS I P E+ TV L C G P P L+W K++ P+
Sbjct: 2947 NTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK 3006
Query: 738 VTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNC---DSSQS 794
+ + L I+ A + D G+YTCI N G + L V P+ DS
Sbjct: 3007 LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESL 3066
Query: 795 SIGHEDDG 802
S+ + +G
Sbjct: 3067 SVVNVREG 3074
Score = 109 bits (273), Expect = 1e-23
Identities = 88/287 (30%), Positives = 124/287 (43%), Gaps = 19/287 (6%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P I+ P + + + L C A + + SP T W+K+ +V+T
Sbjct: 3988 PVIQPQPSELHVILNNPILLPCEA-TGTPSPFIT-WQKEG---INVNTSG-------RNH 4035
Query: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGA 617
A+ + L + D G Y C+ N G+ K KL V P + I
Sbjct: 4036 AVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG-KIKLNVQVPPVISPHLKEYVIAVDK 4094
Query: 618 MARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMA 677
L C A+G P P I+W KDG + R+R + IA V+ D G Y+CMA
Sbjct: 4095 PITLSCEADGLPPPDITWHKDGRAIVESIRQRVL----SSGSLQIAFVQPGDAGHYTCMA 4150
Query: 678 QNTAGGLSANASLTVLETPSFIRPLEDK-TVTRGETAVLQCIAGGSPAPRLNWTKDDGPL 736
N AG S + LTV P IR E TV A+L C+A G P P +NW KD+ L
Sbjct: 4151 ANVAGSSSTSTKLTV-HVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLL 4209
Query: 737 LVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
+ A LI+ + LED+G YTC+ +N G + + L V
Sbjct: 4210 ANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 109 bits (273), Expect = 1e-23
Identities = 82/287 (28%), Positives = 124/287 (43%), Gaps = 23/287 (8%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P I H + + +TL+C A P W KD + + + +
Sbjct: 4079 PVISPHLKEYVIAVDKPITLSCEA--DGLPPPDITWHKDGRAIVESIRQRVLS------- 4129
Query: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGA 617
+ L + V D G Y C+ N GS+ S KLTV+ P T T+ +
Sbjct: 4130 ----SGSLQIAFVQPGDAGHYTCMAANVAGSS-STSTKLTVHVPPRIRSTEGHYTVNENS 4184
Query: 618 MARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMA 677
A L C A+G P P I+W+KD + A + + NV +ED G Y+C+A
Sbjct: 4185 QAILPCVADGIPTPAINWKKD---NVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVA 4241
Query: 678 QNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLL 737
N AG + SLTV P+F D ++ +GE L C A G P P+L WT ++
Sbjct: 4242 NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNN--- 4298
Query: 738 VTERHFFAA-ANQLLIIVDAGLEDAGKYTCIMSNTLGTER--GHIYL 781
+ HF + + L+I ED+G Y C N++G + G +Y+
Sbjct: 4299 IIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYV 4345
Score = 108 bits (270), Expect = 3e-23
Identities = 85/285 (29%), Positives = 120/285 (42%), Gaps = 18/285 (6%)
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
V L C A + +P S W KD + V+T Q +G L+ L D
Sbjct: 1844 VALQCIA-NGIPNP-SITWLKDDQ---PVNTAQGNLKIQSSGRVLQIAKTL------LED 1892
Query: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDL--TIRTGAMARLECAAEGHPAPQ 632
G+Y C+ TN G Q +L V+E PS L T+ +LEC A G+P P
Sbjct: 1893 AGRYTCVATNAAGET-QQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPV 1951
Query: 633 ISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTV 692
I+W KD + M + + I + +I D GIY C+A N+AG SL V
Sbjct: 1952 ITWYKDNRL---LSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQV 2008
Query: 693 LETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHF-FAAANQLL 751
PS V L+C A G PAP L W KD P+ + ++L
Sbjct: 2009 HVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRIL 2068
Query: 752 IIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSI 796
+ A + D G+YTC+ N G ++ I L V PN + ++
Sbjct: 2069 ALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNV 2113
Score = 108 bits (270), Expect = 3e-23
Identities = 89/325 (27%), Positives = 136/325 (41%), Gaps = 24/325 (7%)
Query: 478 AGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDS 537
AG+ L D++ V +K PE + L + + C + S S +P ++ W+KD
Sbjct: 2854 AGEDSLQYDVRVLV-PPIIKGANSDLPEEVTVLVNKSALIECLS-SGSPAPRNS-WQKDG 2910
Query: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLT 597
+ L + D F L IL + N TD G+Y C+ N GS + L
Sbjct: 2911 QPLLEDDHHKF----------LSNGRILQILNTQITDIGRYVCVAENTAGSA-KKYFNLN 2959
Query: 598 VNEMPSFLKTPMD-LTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPE 656
V+ PS + + LT+ L C G P P +SW K+ + P ++P
Sbjct: 2960 VHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKN---EQPIKLNTNTLIVPG 3016
Query: 657 DDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSF----IRPLEDKTVTRGET 712
I K+ D G Y+C+A N AG SLTV PS L V G +
Sbjct: 3017 GRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTS 3076
Query: 713 AVLQCIAGGSPAPRLNWTKDDGPLLVTERHF-FAAANQLLIIVDAGLEDAGKYTCIMSNT 771
L+C + P P + W K+ G ++ H A Q+L I A + D G+Y C N
Sbjct: 3077 VSLECESNAVPPPVITWYKN-GRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINV 3135
Query: 772 LGTERGHIYLNVISSPNCDSSQSSI 796
G + + +LNV P+ + + +
Sbjct: 3136 AGRDDKNFHLNVYVPPSIEGPEREV 3160
Score = 107 bits (268), Expect = 5e-23
Identities = 96/372 (25%), Positives = 145/372 (38%), Gaps = 30/372 (8%)
Query: 486 DLKDFVCDDFLKPQIR--THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDV 543
D K+++ + P I P I LR VTL C S + P W ++ E L
Sbjct: 3608 DDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECK--SDAVPPPVITWLRNGERLQAT 3665
Query: 544 DTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPS 603
L L + N + D Y C+ +N G +++ LTVN P+
Sbjct: 3666 PRVRI----------LSGGRYLQINNADLGDTANYTCVASNIAGKT-TREFILTVNVPPN 3714
Query: 604 FLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIA 663
P L I LEC AEG P P+I+W+KDG A + + E+ I
Sbjct: 3715 IKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAV---LAGNHARYSILENGFLHIQ 3771
Query: 664 NVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSP 723
+ + D G Y CMA N AG L V PS + TV L C A G P
Sbjct: 3772 SAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIP 3831
Query: 724 APRLNWTKDDGPLLVTERH--FFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYL 781
P +NW K+ L V + + ++ L+I+ ++D Y C ++N G ++ + L
Sbjct: 3832 KPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDL 3891
Query: 782 NVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGT---SLIWVIVIYHMRRKNEDY 838
V P SI E + V+ C G S+ W + + + Y
Sbjct: 3892 TVQVPP-------SIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGY 3944
Query: 839 SITNTEELNLPA 850
I ++ + + A
Sbjct: 3945 RILSSGAIEILA 3956
Score = 107 bits (267), Expect = 6e-23
Identities = 78/281 (27%), Positives = 125/281 (44%), Gaps = 21/281 (7%)
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
V L C A + + P+ T W KD+ +L + F+ Q I+ + + +D
Sbjct: 1938 VQLECKA-AGNPVPVIT-WYKDNRLLSGSTSMTFLNRGQ----------IIDIESAQISD 1985
Query: 575 EGKYQCIVTNHFGSN---YSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAP 631
G Y+C+ N G+ YS L V+ PS + + + RLEC A G PAP
Sbjct: 1986 AGIYKCVAINSAGATELFYS----LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAP 2041
Query: 632 QISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLT 691
++W KDG ++ + V+ + + + +I D G Y+C+A N AG + L
Sbjct: 2042 SLTWLKDGSP--VSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLR 2099
Query: 692 VLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLL 751
V P+ + ++ +V + L C + P P L W KD PLL + +L
Sbjct: 2100 VYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVL 2159
Query: 752 IIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSS 792
I DA ++D G+YTC +N G + +N+ PN S
Sbjct: 2160 KIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGS 2200
Score = 106 bits (265), Expect = 1e-22
Identities = 87/310 (28%), Positives = 129/310 (41%), Gaps = 19/310 (6%)
Query: 478 AGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDS 537
AG +DL+ V P I P + + + TL C A ++ WRK+
Sbjct: 3789 AGTDRRRIDLQVHV-----PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSIN--WRKNG 3841
Query: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLT 597
+L +N R L + L + + + D Y+C VTN G + + LT
Sbjct: 3842 HLLNVDQNQNSYR--------LLSSGSLVIISPSVDDTATYECTVTNGAGDD-KRTVDLT 3892
Query: 598 VNEMPSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPED 657
V PS P D + A A + C A G P P I W K+G P R ++
Sbjct: 3893 VQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYR--ILSSG 3950
Query: 658 DVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQC 717
+ +A ++ G Y+C+A+N AG + +L V E P + V +L C
Sbjct: 3951 AIEILAT-QLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPC 4009
Query: 718 IAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERG 777
A G+P+P + W K+ + + R+ + L I A EDAG Y C+ N GT G
Sbjct: 4010 EATGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALG 4069
Query: 778 HIYLNVISSP 787
I LNV P
Sbjct: 4070 KIKLNVQVPP 4079
Score = 105 bits (262), Expect = 2e-22
Identities = 83/316 (26%), Positives = 133/316 (42%), Gaps = 26/316 (8%)
Query: 481 SILNVDLKDFVCDDFLKPQI--RTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDS 537
+I K F D + P I P + + +V L C +P + W KD
Sbjct: 1435 NIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV---KGTPFPDIHWFKDG 1491
Query: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLT 597
+ L+ D E L+ +LHL N D+G+YQC V+N G ++ KLT
Sbjct: 1492 KPLFLGDPNV---------ELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQ-AKDIKLT 1541
Query: 598 VNEMPSFL--KTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMP 655
+ PS D+++ ++ +LEC G P P I+W KDG P + +
Sbjct: 1542 IYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQ---PIMSSSQALYID 1598
Query: 656 EDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETP----SFIRPLEDKTVTRGE 711
+ I ++ D Y+C N AG + + V P + PL +K V
Sbjct: 1599 KGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL-NKQVVIAH 1657
Query: 712 TAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNT 771
+ L+C A G+P+P L W KD P+ + A + L I+ A D G+Y C+ ++
Sbjct: 1658 SLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSV 1717
Query: 772 LGTERGHIYLNVISSP 787
G + ++V+ P
Sbjct: 1718 AGEKEIKYEVDVLVPP 1733
Score = 105 bits (262), Expect = 2e-22
Identities = 73/278 (26%), Positives = 117/278 (42%), Gaps = 16/278 (5%)
Query: 513 MNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNF 572
+N L T ++S W KD L D + L +L +
Sbjct: 3542 VNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQV----------QTLGGGEVLRISTAQV 3591
Query: 573 TDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKT--PMDLTIRTGAMARLECAAEGHPA 630
D G+Y C+ ++ G + ++ + V+ P+ T P D+T+ LEC ++ P
Sbjct: 3592 EDTGRYTCLASSPAGDD-DKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPP 3650
Query: 631 PQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANASL 690
P I+W ++G R+ ++ I N + D Y+C+A N AG + L
Sbjct: 3651 PVITWLRNGER---LQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFIL 3707
Query: 691 TVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAANQL 750
TV P+ + + ++ VL+CIA G P PR+ W KD L + N
Sbjct: 3708 TVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGF 3767
Query: 751 LIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPN 788
L I A + D G+Y C+ +N GT+R I L V P+
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS 3805
Score = 104 bits (260), Expect = 4e-22
Identities = 66/229 (28%), Positives = 108/229 (47%), Gaps = 8/229 (3%)
Query: 564 ILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKT--PMDLTIRTGAMARL 621
++ + +D Y C+ +N G + ++ L V P+ + ++T+ G+ +
Sbjct: 3397 VIRIVRAQVSDVAVYTCVASNRAGVD-NKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSM 3455
Query: 622 ECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTA 681
C +G PAP ++W +DG P + + V V + + ED G Y+C+A N A
Sbjct: 3456 ACITDGTPAPSMAWLRDGQ---PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEA 3512
Query: 682 GGLSANASLTVLETPSF--IRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVT 739
G +S + L VLE P E+ +V L CIA G PAP++ W KD PL T
Sbjct: 3513 GEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQT 3572
Query: 740 ERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPN 788
++ ++L I A +ED G+YTC+ S+ G + + V PN
Sbjct: 3573 DQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPN 3621
Score = 102 bits (255), Expect = 1e-21
Identities = 80/301 (26%), Positives = 125/301 (41%), Gaps = 24/301 (7%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P I+ + + + G+ VTL C A S + S +W K E++ + F AG
Sbjct: 981 PTIQHGQQILSTIEGIPVTLPCKA--SGNPKPSVIWSKKGELI-STSSAKF-----SAGA 1032
Query: 558 ALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFL--------KTPM 609
L++ + + G+Y C TN G +K +LTV P P+
Sbjct: 1033 ----DGSLYVVSPGGEESGEYVCTATNTAGYA-KRKVQLTVYVRPRVFGDQRGLSQDKPV 1087
Query: 610 DLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIED 669
++++ G L C + P P I+W K+ P + H I + D
Sbjct: 1088 EISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPR---HTFLPSGSMKITETRTSD 1144
Query: 670 MGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNW 729
G+Y C+A N AG ++ L V P R + V G+ + C A G+P P + W
Sbjct: 1145 SGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITW 1204
Query: 730 TKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNC 789
+K +LV H + + L I A DAG YTC+ +N GT+ I L+V P
Sbjct: 1205 SKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTV 1264
Query: 790 D 790
+
Sbjct: 1265 E 1265
Score = 101 bits (252), Expect = 3e-21
Identities = 66/232 (28%), Positives = 111/232 (47%), Gaps = 4/232 (1%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECA 624
L + V +DEG Y+CI + G+ +Q V+E P ++ P ++T+ G A L C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTF-FDVSEPPPVIQVPNNVTVTPGERAVLTCL 542
Query: 625 AEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGL 684
++WQ++ D A R+ + + + +VK D G Y CM + G
Sbjct: 543 IISAVDYNLTWQRND-RDVRLAEPARIRTLANLSLE-LKSVKFNDAGEYHCMVSSEGGSS 600
Query: 685 SANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFF 744
+A+ LTV E P ++++ T G + C A G P P++ WT +D +V +
Sbjct: 601 AASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVND-MFIVGSHRYR 659
Query: 745 AAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSI 796
++ L I +A +DAG Y C+ SN+ GT++ + L I +P QS +
Sbjct: 660 MTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVVQSEL 711
Score = 101 bits (251), Expect = 4e-21
Identities = 84/318 (26%), Positives = 130/318 (40%), Gaps = 22/318 (6%)
Query: 485 VDLKDFVCDDFLKPQIRTH--PETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYD 542
VD K + F P + E I L+G + ++ C ++ S W +D + L
Sbjct: 3421 VDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMAC--ITDGTPAPSMAWLRDGQPL-G 3477
Query: 543 VDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMP 602
+D V + +L L D GKY CI +N G S+ L V E P
Sbjct: 3478 LDAHLTVS---------THGMVLQLLKAETEDSGKYTCIASNEAGE-VSKHFILKVLEPP 3527
Query: 603 SF--LKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVF 660
+ ++++ L C A G PAP+++W KDG P + ++ + +V
Sbjct: 3528 HINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGR---PLPQTDQVQTLGGGEVL 3584
Query: 661 FIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLE--DKTVTRGETAVLQCI 718
I+ ++ED G Y+C+A + AG + V P+ E D TV R L+C
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECK 3644
Query: 719 AGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGH 778
+ P P + W ++ L T R + + L I +A L D YTC+ SN G
Sbjct: 3645 SDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTRE 3704
Query: 779 IYLNVISSPNCDSSQSSI 796
L V PN S+
Sbjct: 3705 FILTVNVPPNIKGGPQSL 3722
Score = 99.8 bits (247), Expect = 1e-20
Identities = 81/289 (28%), Positives = 125/289 (43%), Gaps = 31/289 (10%)
Query: 514 NVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFT 573
+VTLTC V+ + P T W KD + L + + + + G L+ T NV
Sbjct: 2496 SVTLTCE-VTGNPVPEIT-WHKDGQPLQEDEAHHII----SGGRFLQIT------NVQVP 2543
Query: 574 DEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKT-----PMDLTIRTGAMARLECAAEGH 628
G+Y C+ ++ G S+ L V P+ P D+T+ + L C A +
Sbjct: 2544 HTGRYTCLASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSY 2602
Query: 629 PAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANA 688
P I+W KDG P R + ++P I N + ++ G YSC+A N AG + +
Sbjct: 2603 PPATITWFKDGT---PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHY 2659
Query: 689 SLTVLETPSF---------IRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVT 739
+ V P + P E K + T L+C A P+ L+W KD PL
Sbjct: 2660 EVKVYIPPIINKGDLWGPGLSPKEVK-IKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD 2718
Query: 740 ERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPN 788
+ AA L I +A + D G+YTC+ SN G + +N+ P+
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPS 2767
Score = 97.1 bits (240), Expect = 8e-20
Identities = 78/309 (25%), Positives = 136/309 (44%), Gaps = 20/309 (6%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYW 552
D + P I ET + +N L + P + +W KD +++ + D +
Sbjct: 1728 DVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNG 1787
Query: 553 QQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMD-- 610
++ L + ++ G Y+C+ N G ++ ++ ++TV+ P+ + +
Sbjct: 1788 RK----------LVIAQAQVSNTGLYRCMAANTAG-DHKKEFEVTVHVPPTIKSSGLSER 1836
Query: 611 LTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPA-ARERRMHVMPEDDVFFIANVKIED 669
+ ++ +A L+C A G P P I+W KD D P + + + V IA +ED
Sbjct: 1837 VVVKYKPVA-LQCIANGIPNPSITWLKD---DQPVNTAQGNLKIQSSGRVLQIAKTLLED 1892
Query: 670 MGIYSCMAQNTAGGLSANASLTVLETPSF--IRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
G Y+C+A N AG + L V E PS + ++TV L+C A G+P P +
Sbjct: 1893 AGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVI 1952
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
W KD+ L + F Q++ I A + DAG Y C+ N+ G L V +P
Sbjct: 1953 TWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAP 2012
Query: 788 NCDSSQSSI 796
+ S + +
Sbjct: 2013 SISGSNNMV 2021
Score = 97.1 bits (240), Expect = 8e-20
Identities = 80/299 (26%), Positives = 120/299 (40%), Gaps = 23/299 (7%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFVRYWQQA- 555
P I P + + +TCTA S P ++ W T+N +R +
Sbjct: 3897 PSIADEPTDFLVTKHAPAVITCTA---SGVPFPSIHW-----------TKNGIRLLPRGD 3942
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
G + + + + G+Y C+ N GS + + L V+E P P +L +
Sbjct: 3943 GYRILSSGAIEILATQLNHAGRYTCVARNAAGSAH-RHVTLHVHEPPVIQPQPSELHVIL 4001
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
L C A G P+P I+WQK+G R H + I+ ED G Y C
Sbjct: 4002 NNPILLPCEATGTPSPFITWQKEG---INVNTSGRNHAVLPSGGLQISRAVREDAGTYMC 4058
Query: 676 MAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGP 735
+AQN AG L V P L++ + + L C A G P P + W KD
Sbjct: 4059 VAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRA 4118
Query: 736 LLVTERHFFAAANQLLI-IVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQ 793
++ + R ++ L I V G DAG YTC+ +N G+ L V P S++
Sbjct: 4119 IVESIRQRVLSSGSLQIAFVQPG--DAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTE 4175
Score = 96.3 bits (238), Expect = 1e-19
Identities = 67/224 (29%), Positives = 97/224 (43%), Gaps = 8/224 (3%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECA 624
L L NV D G Y C+ N G + + LTV+ +P+F + P D+++ G RL C
Sbjct: 4224 LILENVVLEDSGFYTCVANNAAGED-THTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK 4282
Query: 625 AEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGL 684
A G P P+++W + PA + I V ED G Y C A+N+ G +
Sbjct: 4283 ATGIPLPKLTWTFNNNI-IPA----HFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFV 4337
Query: 685 SANASLTVLETPSFIRPLEDKTVTR-GETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHF 743
A + V E P F + G A+L C G P P + W + + ++ R
Sbjct: 4338 KAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHR-I 4396
Query: 744 FAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
N L I EDAG YTC+ +N G + L + S P
Sbjct: 4397 RQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPP 4440
Score = 94.0 bits (232), Expect = 7e-19
Identities = 66/229 (28%), Positives = 100/229 (43%), Gaps = 9/229 (3%)
Query: 564 ILHLFNVNFTDEGKYQCIVTNHFGSNYSQKA-KLTVNEMPSFLKT--PMDLTIRTGAMAR 620
IL LF D G+Y C N G+ SQK + V P+ + T P ++++
Sbjct: 1415 ILKLFRATPEDAGRYSCKAINIAGT--SQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVA 1472
Query: 621 LECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNT 680
LEC +G P P I W KDG F + + ++ V + N + D G Y C N
Sbjct: 1473 LECQVKGTPFPDIHWFKDGKPLFLG--DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 681 AGGLSANASLTVLETPSFI--RPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLV 738
AG + + LT+ PS D +V L+C G P P + W KD P++
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 739 TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSP 787
+ + + Q L I A + D+ YTC ++N GT +++V P
Sbjct: 1591 SSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPP 1639
Score = 94.0 bits (232), Expect = 7e-19
Identities = 64/236 (27%), Positives = 100/236 (42%), Gaps = 10/236 (4%)
Query: 564 ILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLEC 623
IL L + +D G+Y C+ N G + L V P+ + ++++ L C
Sbjct: 2067 ILALTSAQISDTGRYTCVAVNAAGEK-QRDIDLRVYVPPNIMGEEQNVSVLISQAVELLC 2125
Query: 624 AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGG 683
++ P P ++W KDG P ++ + + V I + +++D G Y+C A N AG
Sbjct: 2126 QSDAIPPPTLTWLKDG---HPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGK 2182
Query: 684 LSANASLTVLETPSF--IRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTER 741
N ++ + P+ L TV G L C + G P P L W K P+L
Sbjct: 2183 TEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSM 2242
Query: 742 ---HFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQS 794
+ QL I + A DA Y+C+ SN GT + L V P +S S
Sbjct: 2243 GRVRILSGGRQLQISI-AEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGS 2297
Score = 90.5 bits (223), Expect = 8e-18
Identities = 73/291 (25%), Positives = 119/291 (40%), Gaps = 16/291 (5%)
Query: 512 GMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVN 571
G NVTL C + + WR+ + F R + + + T L + N+
Sbjct: 807 GSNVTLPCYVQGYPEPTIK--WRRLDNMPI------FSRPFSVSSISQLRTGALFILNLW 858
Query: 572 FTDEGKYQCIVTNHFGSNYSQKAKLTVNEM--PSFLKTPMDLTIRTGAMARLECAA-EGH 628
+D+G Y C N FG S+ +TV + P +P + G L C G+
Sbjct: 859 ASDKGTYICEAENQFGKIQSETT-VTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGN 917
Query: 629 PAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGLSANA 688
P P+ W K+ + + D I V+++D G Y+C+A N AG +
Sbjct: 918 PIPERRWIKNSAM----LLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTT 973
Query: 689 SLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAAN 748
S+ V P+ + + G L C A G+P P + W+K + + F A A+
Sbjct: 974 SVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGAD 1033
Query: 749 QLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSSQSSIGHE 799
L +V G E++G+Y C +NT G + + L V P Q + +
Sbjct: 1034 GSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQD 1084
Score = 86.7 bits (213), Expect = 1e-16
Identities = 85/301 (28%), Positives = 134/301 (44%), Gaps = 30/301 (9%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSEILYDVDTENFVRYWQQAG 556
P+I+ P+ + G V + C A +P+ + W K + VD E+ V
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNA---QGTPLPVITWSKGGSTML-VDGEHHVS------ 1220
Query: 557 EALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSF--LKTPMDLTIR 614
L + +D G Y C+ TN G++ ++ L V E P+ L+ P + T +
Sbjct: 1221 ---NPDGTLSIDQATPSDAGIYTCVATNIAGTDETE-ITLHVQEPPTVEDLEPPYNTTFQ 1276
Query: 615 TG-AMARLE--CAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMG 671
A R+E C A+G P P I W +G RE + ++ + + IA+V D G
Sbjct: 1277 ERVANQRIEFPCPAKGTPKPTIKWLHNGRE--LTGREPGISILEDGTLLVIASVTPYDNG 1334
Query: 672 IYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKT---VTRGETAVLQCIAGGSPAPRLN 728
Y C+A N AG +L V P I+ E T V + L C G+P+P +
Sbjct: 1335 EYICVAVNEAGTTERKYNLKV-HVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIM 1393
Query: 729 WTKDDGPLLVTERHFFAAAN--QLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISS 786
W KD+ + VTE N ++L + A EDAG+Y+C N GT + + ++V+
Sbjct: 1394 WYKDN--VQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVP 1451
Query: 787 P 787
P
Sbjct: 1452 P 1452
Score = 86.7 bits (213), Expect = 1e-16
Identities = 67/237 (28%), Positives = 106/237 (44%), Gaps = 13/237 (5%)
Query: 559 LEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLT---IRT 615
LE ++L + +V D G+Y C+ N G+ +K L V+ +P +K +T +
Sbjct: 1317 LEDGTLLVIASVTPYDNGEYICVAVNEAGTT-ERKYNLKVH-VPPVIKDKEQVTNVSVLL 1374
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
+ L C EG P+P I W KD + + + + + ED G YSC
Sbjct: 1375 NQLTNLFCEVEGTPSPIIMWYKD---NVQVTESSTIQTVNNGKILKLFRATPEDAGRYSC 1431
Query: 676 MAQNTAGGLSANASLTVLETPSFIR---PLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
A N AG ++ VL P+ I P E V + A L+C G+P P ++W KD
Sbjct: 1432 KAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVA-LECQVKGTPFPDIHWFKD 1490
Query: 733 DGPLLVTERHF-FAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPN 788
PL + + + Q+L + +A D G+Y C +SN G + I L + P+
Sbjct: 1491 GKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPS 1547
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/231 (27%), Positives = 96/231 (41%), Gaps = 11/231 (4%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMD----LTIRTGAMAR 620
L + +D G+Y CI N G + +K LTV PS + + +R G
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVS 3078
Query: 621 LECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNT 680
LEC + P P I+W K+G + ++ + + I ++ D G Y C A N
Sbjct: 3079 LECESNAVPPPVITWYKNGRM---ITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINV 3135
Query: 681 AGGLSANASLTVLETPSFIRPLEDKTV-TRGETAVLQCIAGGSPAPRLNWTKDDGPLLVT 739
AG N L V PS P + V T L C A G P P + W K+ + +
Sbjct: 3136 AGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENS 3195
Query: 740 E--RHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPN 788
+ + L I + D+G YTCI SN G + + +L++ P+
Sbjct: 3196 DSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPS 3246
Score = 82.0 bits (201), Expect = 3e-15
Identities = 57/213 (26%), Positives = 89/213 (41%), Gaps = 8/213 (3%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECA 624
L + N D G Y C+ +N G++ Q + L E P + +L + G + +EC
Sbjct: 666 LFIKNAAPKDAGIYGCLASNSAGTD-KQNSTLRYIEAPKLMVVQSELLVALGDITVMECK 724
Query: 625 AEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAGGL 684
G P PQ+ W K D + + P + I + D G Y+C+A N AG
Sbjct: 725 TSGIPPPQVKWFKG---DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRA 781
Query: 685 SANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFF 744
+ +L V P FI+ D ++ G L C G P P + W + D + +
Sbjct: 782 TGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSV 841
Query: 745 AAANQL----LIIVDAGLEDAGKYTCIMSNTLG 773
++ +QL L I++ D G Y C N G
Sbjct: 842 SSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 77.0 bits (188), Expect = 9e-14
Identities = 59/213 (27%), Positives = 87/213 (40%), Gaps = 7/213 (3%)
Query: 563 SILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKT-PMDLTIRTGAMARL 621
S L + V+ D G Y C N G + V E P F P + G A L
Sbjct: 4311 SELVIERVSKEDSGTYVCTAENSVGF-VKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAIL 4369
Query: 622 ECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTA 681
C +G P P I W + G D + R ++ N ED G Y+C+A N A
Sbjct: 4370 NCEVKGDPTPTIQWNRKG-VDIEISHRIRQLGNGSLAIYGTVN---EDAGDYTCVATNEA 4425
Query: 682 GGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTER 741
G + + SLT+ P + + G +L C A G P P + W++ G + +
Sbjct: 4426 GVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSR-QGHSISWDD 4484
Query: 742 HFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGT 774
+N L I DA ED ++ C+ N +G+
Sbjct: 4485 RVNVLSNNSLYIADAQKEDTSEFECVARNLMGS 4517
Score = 75.1 bits (183), Expect = 3e-13
Identities = 64/235 (27%), Positives = 94/235 (40%), Gaps = 13/235 (5%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSF---LKTPMDLTIRTGAMARL 621
LH+ +D Y C V N G+ + + V P L TP++ + L
Sbjct: 1603 LHIPRAQVSDSATYTCHVANVAGTA-EKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTL 1661
Query: 622 ECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTA 681
EC A G+P+P ++W KDG P + + I + + D G Y C+A + A
Sbjct: 1662 ECKAAGNPSPILTWLKDG---VPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVA 1718
Query: 682 GGLSANASLTVLETPSFIRPLEDK--TVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVT 739
G + VL P+ E V L C GSP P + W KD L+
Sbjct: 1719 GEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDG--QLID 1776
Query: 740 ERHFFAAA--NQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISSPNCDSS 792
ER F + L+I A + + G Y C+ +NT G + + V P SS
Sbjct: 1777 ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSS 1831
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/190 (24%), Positives = 78/190 (41%), Gaps = 18/190 (9%)
Query: 503 HPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYT 562
+P I G N L C D + W + D++ + +R Q G
Sbjct: 4355 YPSNWIEPLGGNAILNCEV--KGDPTPTIQWNRKG---VDIEISHRIR---QLGNGS--- 4403
Query: 563 SILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLE 622
L ++ D G Y C+ TN G + LT+ P P++ I G L
Sbjct: 4404 --LAIYGTVNEDAGDYTCVATNEAGV-VERSMSLTLQSPPIITLEPVETVINAGGKIILN 4460
Query: 623 CAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
C A G P P I+W + G + + + R++V+ + ++ IA+ + ED + C+A+N G
Sbjct: 4461 CQATGEPQPTITWSRQGHS---ISWDDRVNVLSNNSLY-IADAQKEDTSEFECVARNLMG 4516
Query: 683 GLSANASLTV 692
+ + V
Sbjct: 4517 SVLVRVPVIV 4526
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 132 bits (333), Expect = 1e-30
Identities = 127/429 (29%), Positives = 197/429 (45%), Gaps = 32/429 (7%)
Query: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
+ L L N+I+I++ +F+ L L L++ RN I ++ GAF GL N+ LEL N LT
Sbjct: 79 RLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTT 138
Query: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL-SYNQLTRLDESAFVGLSL 336
+ G L L++L++ N IE I A+ L LDL +L+ + E AF GLS
Sbjct: 139 IPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSN 198
Query: 337 LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN 396
L LNL + I + L L LDL N +S AI S F GL L KL + +
Sbjct: 199 LRYLNLAMCNLREIPN--LTPLIKLDELDLSGNHLS-AIRPGS--FQGLMHLQKLWMIQS 253
Query: 397 QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQT-HLKELILNTSSLLCDCHLKWLL 455
QI+ I + AF L+SL ++L +N + + + F+ HL+ + L+ + C+C + WL
Sbjct: 254 QIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLS 313
Query: 456 QWLVDNNFQHSVNVS-CAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
W+ D ++ + C P L G+ I +D F C P I P + GM
Sbjct: 314 WWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC---YAPVIVEPPADLNVTEGMA 370
Query: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTD 574
L C A S+S + +S + + + + + A+ L+ NV D
Sbjct: 371 AELKCRA-STSLTSVSWITPNGTVMTHGA---------YKVRIAVLSDGTLNFTNVTVQD 420
Query: 575 EGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMD----LTIRTGAMARLECAAEGH-- 628
G Y C+V+N G N + A L V + TP +T+ T ++ E +
Sbjct: 421 TGMYTCMVSNSVG-NTTASATLNVTAATT---TPFSYFSTVTVETMEPSQDEARTTDNNV 476
Query: 629 -PAPQISWQ 636
P P + W+
Sbjct: 477 GPTPVVDWE 485
Score = 97.8 bits (242), Expect = 5e-20
Identities = 74/222 (33%), Positives = 118/222 (53%), Gaps = 26/222 (11%)
Query: 149 LDLSSNIISEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMI 207
L+L N I IK +SF ++ L+ L LS N I T+E G F+ L ++L ++L NR++ I
Sbjct: 81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGL-ANLNTLELFDNRLTTI 139
Query: 208 PPKIF-KLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKM-QRNGISKLKDGAFFGLNN- 264
P F L L+ L L+ N I+ + F + SLR L + + +S + +GAF GL+N
Sbjct: 140 PNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNL 199
Query: 265 ---------------------MEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
++EL+L N+L+ + G GL LQ+L++ Q+ I+ I
Sbjct: 200 RYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIE 259
Query: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDN 345
+A++ Q L E++L++N LT L F L LER++L N
Sbjct: 260 RNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
Score = 51.6 bits (122), Expect = 4e-06
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 5/132 (3%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFF 661
P ++ P DL + G A L+C A +SW GT + + D
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTS-LTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
Query: 662 IANVKIEDMGIYSCMAQNTAGGLSANASLTV---LETP-SFIRPLEDKTVTRGETAVLQC 717
NV ++D G+Y+CM N+ G +A+A+L V TP S+ + +T+ +
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTT 472
Query: 718 IAGGSPAPRLNW 729
P P ++W
Sbjct: 473 DNNVGPTPVVDW 484
Score = 40.8 bits (94), Expect = 0.007
Identities = 26/94 (27%), Positives = 44/94 (46%), Gaps = 4/94 (4%)
Query: 696 PSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAA---NQLLI 752
P + P D VT G A L+C A S ++W +G ++ + A + L
Sbjct: 354 PVIVEPPADLNVTEGMAAELKCRASTS-LTSVSWITPNGTVMTHGAYKVRIAVLSDGTLN 412
Query: 753 IVDAGLEDAGKYTCIMSNTLGTERGHIYLNVISS 786
+ ++D G YTC++SN++G LNV ++
Sbjct: 413 FTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAA 446
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 130 bits (327), Expect = 7e-30
Identities = 131/454 (28%), Positives = 206/454 (45%), Gaps = 36/454 (7%)
Query: 191 SSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNG 250
S+ V R +S +P I + ++L L N I++++ TF+ L L L++ RN
Sbjct: 53 SNQFSKVVCTRRGLSEVPQGIPS--NTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNS 110
Query: 251 ISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFC 310
I +++ GAF GL ++ LEL N LT + G L L++L++ N IE I A+
Sbjct: 111 IRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRV 170
Query: 311 QRLSELDL-SYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN 369
L LDL +L + E AF GL L+ LNLG + + + L L+ L++ N
Sbjct: 171 PSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKDMPN--LTPLVGLEELEMSGN 228
Query: 370 EISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENA 429
E +F GL+SL KL + +Q+ I + AF GL SL L+L +N + S+ +
Sbjct: 229 HFP---EIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDL 285
Query: 430 FSQ-THLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVS-CAHPEWLAGQSILNVDL 487
F+ +L EL L+ + CDC + WL WL + +S C P + G+ ++ VD
Sbjct: 286 FTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCHAPMHMRGRYLVEVDQ 345
Query: 488 KDFVCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-W-RKDSEILYDVDT 545
F C P I P + G L C PMS+V W + +L
Sbjct: 346 ASFQCS---APFIMDAPRDLNISEGRMAELKCRT-----PPMSSVKWLLPNGTVLSHASR 397
Query: 546 ENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFG-SNYSQKAKLTVNEMP-- 602
+ ++ L+ +V +D G Y C+VTN G SN S ++ E+
Sbjct: 398 HPRI--------SVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTS 449
Query: 603 --SFLKTPMDLTIRTGAMARLECAAEGHPAPQIS 634
SF T +T+ T ++ + + P P S
Sbjct: 450 NYSFFTT---VTVETTEISPEDTTRKYKPVPTTS 480
Score = 85.9 bits (211), Expect = 2e-16
Identities = 87/329 (26%), Positives = 142/329 (43%), Gaps = 56/329 (17%)
Query: 21 LSRLLFIAQTALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAIL 80
L+ ++I A+ +AG CP+ CSC
Sbjct: 24 LTAQVWILCAAIAAAASAGPQNCPSVCSC------------------------------- 52
Query: 81 DFSHNRLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQAL 140
S +V L+E+P G P SN L+L+ N I I A
Sbjct: 53 ---------------SNQFSKVVCTRRGLSEVPQ-GIP-SNTRYLNLMENNIQMIQADTF 95
Query: 141 QFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKL 199
+ LE L L N I +I+ +F + L L L +N +T + +G F+ L S L + L
Sbjct: 96 RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYL-SKLRELWL 154
Query: 200 NRNRMSMIPPKIF-KLPHLQFLEL-KRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKD- 256
N + IP F ++P L L+L + +++ + F+GL +L+ L + G+ +KD
Sbjct: 155 RNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNL---GMCNIKDM 211
Query: 257 GAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSEL 316
L +EELE+ N+ + G +GL L++L+V + + I +A++ L EL
Sbjct: 212 PNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVEL 271
Query: 317 DLSYNQLTRLDESAFVGLSLLERLNLGDN 345
+L++N L+ L F L L L+L N
Sbjct: 272 NLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
Score = 55.5 bits (132), Expect = 3e-07
Identities = 71/299 (23%), Positives = 120/299 (40%), Gaps = 50/299 (16%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFP-AARERRMHVMPEDDVF 660
P + P DL I G MA L+C P + W GT A+R R+ V+ + +
Sbjct: 353 PFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLSHASRHPRISVLNDGTLN 410
Query: 661 FIANVKIEDMGIYSCMAQNTAGGLSANASLTVLETPSFIRPLEDKTVTRGETAVLQCIAG 720
F ++V + D G+Y+CM N AG +A+A L V T ET +
Sbjct: 411 F-SHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAELNTSNYSFFTTVTVETTEI----- 464
Query: 721 GSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIY 780
SP + T+ P+ T + A YT + + T R
Sbjct: 465 -SPE---DTTRKYKPVPTTSTGYQPA-----------------YTTSTTVLIQTTRVPKQ 503
Query: 781 LNVISSPNCDSSQSSIGHEDDGWTTVGIVIIVVVCCVVGTSLI---WVIVIYHMRRKNED 837
+ V ++ D Q+S+ D+ T I+I C V +L+ +IV Y +R++++
Sbjct: 504 VAVPATDTTDKMQTSL---DEVMKTTKIII----GCFVAVTLLAAAMLIVFYKLRKRHQQ 556
Query: 838 YSIT----NTEELNLPADIPSYLSSQGTLSEPQEGYSNSEAGSHQQLMPPANGYIHKGT 892
S E + + DIP+ S+ T + + +G ++P + +I+ T
Sbjct: 557 RSTVTAARTVEIIQVDEDIPAATSAAATAA------PSGVSGEGAVVLPTIHDHINYNT 609
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 129 bits (325), Expect = 1e-29
Identities = 89/298 (29%), Positives = 130/298 (43%), Gaps = 27/298 (9%)
Query: 496 LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
L+ R +P ++ G + C P + W+KD L D D +R +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGK-- 185
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
L + +D GKY C+ TN G S+ A+LTV E PSF+K P +L +
Sbjct: 186 ---------LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
A +C A G P P + W+KD G + P +R + + +D I V DMG Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 676 MAQNTAGGLSANASLTV---LETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
+A+N G A+A+LTV E P F+ D+ V G T QC A G+P P + W ++
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 733 DGPLLV-------TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
L+ + F + L I + D G Y C N G+ YL V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (300), Expect = 9e-27
Identities = 93/296 (31%), Positives = 130/296 (43%), Gaps = 17/296 (5%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSE-ILYDVDTENFVR 550
+DF P+I HP +I +G TL C A P T+ W K E + D D R
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKA---EGRPTPTIEWYKGGERVETDKDDPRSHR 80
Query: 551 YWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM-PSFLKTPM 609
+G +L + I+H + DEG Y C+ N+ G S A L V + F + P
Sbjct: 81 MLLPSG-SLFFLRIVH-GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 610 DLTIRTGAMARLEC-AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIE 668
D+ + G A +EC GHP P ISW+KDG ++ + I +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKS 194
Query: 669 DMGIYSCMAQNTAGGLSAN-ASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
D G Y C+ N G + A LTVLE PSF++ + VT ++A +C A G P P +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
W KDDG L + + + L I D G YTC+ N +G L V
Sbjct: 255 RWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 102 bits (254), Expect = 2e-21
Identities = 76/234 (32%), Positives = 103/234 (44%), Gaps = 18/234 (7%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTV---NEMPSFLKTPMDLTIRTGAMARL 621
L + V D G Y C+ N G + A LTV +E P F+ P D + G
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 622 ECAAEGHPAPQISWQKDGGTDF-----PAARERRMHVMPEDDVFFIANVKIEDMGIYSCM 676
+C A G+P P I W+++G + P R V D+ I NV+ D+G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVGYYICQ 393
Query: 677 AQNTAGGLSANASLTVLET-----PSFIR--PLEDKTVTRGETAVLQCIAGGSPAPRLNW 729
N AG + A L V + P IR P+ ++TV T VL C+A GSP P + W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVPTILW 452
Query: 730 TKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
KD + + N +L I A L D G+YTCI S G Y+ V
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 94.0 bits (232), Expect = 7e-19
Identities = 68/198 (34%), Positives = 94/198 (47%), Gaps = 13/198 (6%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG---GTDFPAARERRMHVMPEDD 658
P ++ P DL + G A L C AEG P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 659 VFFIANV----KIEDMGIYSCMAQNTAG-GLSANASLTV-LETPSFIRPLEDKTVTRGET 712
+FF+ V D G+Y C+A+N G +S NASL V + F + D V GE
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 713 AVLQC-IAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNT 771
AV++C G P P ++W KD PL + +L+I DAGKY C+ +N
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206
Query: 772 LGTERGHI-YLNVISSPN 788
+G + L V+ P+
Sbjct: 207 VGERESEVAELTVLERPS 224
Score = 60.5 bits (145), Expect = 8e-09
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P P + G VT C A + + WR++ ++N + +Q
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREG-------SQNLLFSYQPPQS 365
Query: 558 ALEY----TSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM------PSFLKT 607
+ + T L + NV +D G Y C N GS + KA L V ++ P +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQG 424
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P++ T+ L C A G P P I W+KDG + ++ R+ + E+ V I K+
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKL 481
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP 701
D G Y+C+A +G + +A + V E ++P
Sbjct: 482 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 129 bits (325), Expect = 1e-29
Identities = 89/298 (29%), Positives = 130/298 (43%), Gaps = 27/298 (9%)
Query: 496 LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
L+ R +P ++ G + C P + W+KD L D D +R +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGK-- 185
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
L + +D GKY C+ TN G S+ A+LTV E PSF+K P +L +
Sbjct: 186 ---------LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
A +C A G P P + W+KD G + P +R + + +D I V DMG Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 676 MAQNTAGGLSANASLTV---LETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
+A+N G A+A+LTV E P F+ D+ V G T QC A G+P P + W ++
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 733 DGPLLV-------TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
L+ + F + L I + D G Y C N G+ YL V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (300), Expect = 9e-27
Identities = 93/296 (31%), Positives = 130/296 (43%), Gaps = 17/296 (5%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSE-ILYDVDTENFVR 550
+DF P+I HP +I +G TL C A P T+ W K E + D D R
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKA---EGRPTPTIEWYKGGERVETDKDDPRSHR 80
Query: 551 YWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM-PSFLKTPM 609
+G +L + I+H + DEG Y C+ N+ G S A L V + F + P
Sbjct: 81 MLLPSG-SLFFLRIVH-GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 610 DLTIRTGAMARLEC-AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIE 668
D+ + G A +EC GHP P ISW+KDG ++ + I +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKS 194
Query: 669 DMGIYSCMAQNTAGGLSAN-ASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
D G Y C+ N G + A LTVLE PSF++ + VT ++A +C A G P P +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
W KDDG L + + + L I D G YTC+ N +G L V
Sbjct: 255 RWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 102 bits (254), Expect = 2e-21
Identities = 76/234 (32%), Positives = 103/234 (44%), Gaps = 18/234 (7%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTV---NEMPSFLKTPMDLTIRTGAMARL 621
L + V D G Y C+ N G + A LTV +E P F+ P D + G
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 622 ECAAEGHPAPQISWQKDGGTDF-----PAARERRMHVMPEDDVFFIANVKIEDMGIYSCM 676
+C A G+P P I W+++G + P R V D+ I NV+ D+G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVGYYICQ 393
Query: 677 AQNTAGGLSANASLTVLET-----PSFIR--PLEDKTVTRGETAVLQCIAGGSPAPRLNW 729
N AG + A L V + P IR P+ ++TV T VL C+A GSP P + W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVPTILW 452
Query: 730 TKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
KD + + N +L I A L D G+YTCI S G Y+ V
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 94.0 bits (232), Expect = 7e-19
Identities = 68/198 (34%), Positives = 94/198 (47%), Gaps = 13/198 (6%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG---GTDFPAARERRMHVMPEDD 658
P ++ P DL + G A L C AEG P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 659 VFFIANV----KIEDMGIYSCMAQNTAG-GLSANASLTV-LETPSFIRPLEDKTVTRGET 712
+FF+ V D G+Y C+A+N G +S NASL V + F + D V GE
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 713 AVLQC-IAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNT 771
AV++C G P P ++W KD PL + +L+I DAGKY C+ +N
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206
Query: 772 LGTERGHI-YLNVISSPN 788
+G + L V+ P+
Sbjct: 207 VGERESEVAELTVLERPS 224
Score = 60.5 bits (145), Expect = 8e-09
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P P + G VT C A + + WR++ ++N + +Q
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREG-------SQNLLFSYQPPQS 365
Query: 558 ALEY----TSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM------PSFLKT 607
+ + T L + NV +D G Y C N GS + KA L V ++ P +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQG 424
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P++ T+ L C A G P P I W+KDG + ++ R+ + E+ V I K+
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKL 481
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP 701
D G Y+C+A +G + +A + V E ++P
Sbjct: 482 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 129 bits (325), Expect = 1e-29
Identities = 89/298 (29%), Positives = 130/298 (43%), Gaps = 27/298 (9%)
Query: 496 LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
L+ R +P ++ G + C P + W+KD L D D +R +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGK-- 185
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
L + +D GKY C+ TN G S+ A+LTV E PSF+K P +L +
Sbjct: 186 ---------LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
A +C A G P P + W+KD G + P +R + + +D I V DMG Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 676 MAQNTAGGLSANASLTV---LETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
+A+N G A+A+LTV E P F+ D+ V G T QC A G+P P + W ++
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 733 DGPLLV-------TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
L+ + F + L I + D G Y C N G+ YL V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (300), Expect = 9e-27
Identities = 93/296 (31%), Positives = 130/296 (43%), Gaps = 17/296 (5%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSE-ILYDVDTENFVR 550
+DF P+I HP +I +G TL C A P T+ W K E + D D R
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKA---EGRPTPTIEWYKGGERVETDKDDPRSHR 80
Query: 551 YWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM-PSFLKTPM 609
+G +L + I+H + DEG Y C+ N+ G S A L V + F + P
Sbjct: 81 MLLPSG-SLFFLRIVH-GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 610 DLTIRTGAMARLEC-AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIE 668
D+ + G A +EC GHP P ISW+KDG ++ + I +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKS 194
Query: 669 DMGIYSCMAQNTAGGLSAN-ASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
D G Y C+ N G + A LTVLE PSF++ + VT ++A +C A G P P +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
W KDDG L + + + L I D G YTC+ N +G L V
Sbjct: 255 RWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 102 bits (254), Expect = 2e-21
Identities = 76/234 (32%), Positives = 103/234 (44%), Gaps = 18/234 (7%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTV---NEMPSFLKTPMDLTIRTGAMARL 621
L + V D G Y C+ N G + A LTV +E P F+ P D + G
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 622 ECAAEGHPAPQISWQKDGGTDF-----PAARERRMHVMPEDDVFFIANVKIEDMGIYSCM 676
+C A G+P P I W+++G + P R V D+ I NV+ D+G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVGYYICQ 393
Query: 677 AQNTAGGLSANASLTVLET-----PSFIR--PLEDKTVTRGETAVLQCIAGGSPAPRLNW 729
N AG + A L V + P IR P+ ++TV T VL C+A GSP P + W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVPTILW 452
Query: 730 TKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
KD + + N +L I A L D G+YTCI S G Y+ V
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 94.0 bits (232), Expect = 7e-19
Identities = 68/198 (34%), Positives = 94/198 (47%), Gaps = 13/198 (6%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG---GTDFPAARERRMHVMPEDD 658
P ++ P DL + G A L C AEG P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 659 VFFIANV----KIEDMGIYSCMAQNTAG-GLSANASLTV-LETPSFIRPLEDKTVTRGET 712
+FF+ V D G+Y C+A+N G +S NASL V + F + D V GE
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 713 AVLQC-IAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNT 771
AV++C G P P ++W KD PL + +L+I DAGKY C+ +N
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206
Query: 772 LGTERGHI-YLNVISSPN 788
+G + L V+ P+
Sbjct: 207 VGERESEVAELTVLERPS 224
Score = 60.5 bits (145), Expect = 8e-09
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P P + G VT C A + + WR++ ++N + +Q
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREG-------SQNLLFSYQPPQS 365
Query: 558 ALEY----TSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM------PSFLKT 607
+ + T L + NV +D G Y C N GS + KA L V ++ P +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQG 424
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P++ T+ L C A G P P I W+KDG + ++ R+ + E+ V I K+
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKL 481
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP 701
D G Y+C+A +G + +A + V E ++P
Sbjct: 482 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 129 bits (325), Expect = 1e-29
Identities = 89/298 (29%), Positives = 130/298 (43%), Gaps = 27/298 (9%)
Query: 496 LKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQA 555
L+ R +P ++ G + C P + W+KD L D D +R +
Sbjct: 129 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTIS-WKKDGSPLDDKDERITIRGGK-- 185
Query: 556 GEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRT 615
L + +D GKY C+ TN G S+ A+LTV E PSF+K P +L +
Sbjct: 186 ---------LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Query: 616 GAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSC 675
A +C A G P P + W+KD G + P +R + + +D I V DMG Y+C
Sbjct: 237 DDSAEFKCEARGDPVPTVRWRKDDG-ELPKSR----YEIRDDHTLKIRKVTAGDMGSYTC 291
Query: 676 MAQNTAGGLSANASLTV---LETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKD 732
+A+N G A+A+LTV E P F+ D+ V G T QC A G+P P + W ++
Sbjct: 292 VAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 351
Query: 733 DGPLLV-------TERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
L+ + F + L I + D G Y C N G+ YL V
Sbjct: 352 GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV 409
Score = 120 bits (300), Expect = 9e-27
Identities = 93/296 (31%), Positives = 130/296 (43%), Gaps = 17/296 (5%)
Query: 493 DDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTV-WRKDSE-ILYDVDTENFVR 550
+DF P+I HP +I +G TL C A P T+ W K E + D D R
Sbjct: 25 EDF-PPRIVEHPSDLIVSKGEPATLNCKA---EGRPTPTIEWYKGGERVETDKDDPRSHR 80
Query: 551 YWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM-PSFLKTPM 609
+G +L + I+H + DEG Y C+ N+ G S A L V + F + P
Sbjct: 81 MLLPSG-SLFFLRIVH-GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
Query: 610 DLTIRTGAMARLEC-AAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIE 668
D+ + G A +EC GHP P ISW+KDG ++ + I +
Sbjct: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKS 194
Query: 669 DMGIYSCMAQNTAGGLSAN-ASLTVLETPSFIRPLEDKTVTRGETAVLQCIAGGSPAPRL 727
D G Y C+ N G + A LTVLE PSF++ + VT ++A +C A G P P +
Sbjct: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 728 NWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
W KDDG L + + + L I D G YTC+ N +G L V
Sbjct: 255 RWRKDDGEL--PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 102 bits (254), Expect = 2e-21
Identities = 76/234 (32%), Positives = 103/234 (44%), Gaps = 18/234 (7%)
Query: 565 LHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTV---NEMPSFLKTPMDLTIRTGAMARL 621
L + V D G Y C+ N G + A LTV +E P F+ P D + G
Sbjct: 276 LKIRKVTAGDMGSYTCVAENMVGKAEAS-ATLTVQVGSEPPHFVVKPRDQVVALGRTVTF 334
Query: 622 ECAAEGHPAPQISWQKDGGTDF-----PAARERRMHVMPEDDVFFIANVKIEDMGIYSCM 676
+C A G+P P I W+++G + P R V D+ I NV+ D+G Y C
Sbjct: 335 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQRSDVGYYICQ 393
Query: 677 AQNTAGGLSANASLTVLET-----PSFIR--PLEDKTVTRGETAVLQCIAGGSPAPRLNW 729
N AG + A L V + P IR P+ ++TV T VL C+A GSP P + W
Sbjct: 394 TLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVPTILW 452
Query: 730 TKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
KD + + N +L I A L D G+YTCI S G Y+ V
Sbjct: 453 RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 506
Score = 94.0 bits (232), Expect = 7e-19
Identities = 68/198 (34%), Positives = 94/198 (47%), Gaps = 13/198 (6%)
Query: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDG---GTDFPAARERRMHVMPEDD 658
P ++ P DL + G A L C AEG P P I W K G TD R RM ++P
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM-LLPSGS 87
Query: 659 VFFIANV----KIEDMGIYSCMAQNTAG-GLSANASLTV-LETPSFIRPLEDKTVTRGET 712
+FF+ V D G+Y C+A+N G +S NASL V + F + D V GE
Sbjct: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
Query: 713 AVLQC-IAGGSPAPRLNWTKDDGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNT 771
AV++C G P P ++W KD PL + +L+I DAGKY C+ +N
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY-TRKSDAGKYVCVGTNM 206
Query: 772 LGTERGHI-YLNVISSPN 788
+G + L V+ P+
Sbjct: 207 VGERESEVAELTVLERPS 224
Score = 60.5 bits (145), Expect = 8e-09
Identities = 55/214 (25%), Positives = 91/214 (42%), Gaps = 23/214 (10%)
Query: 498 PQIRTHPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGE 557
P P + G VT C A + + WR++ ++N + +Q
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREG-------SQNLLFSYQPPQS 365
Query: 558 ALEY----TSILHLFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEM------PSFLKT 607
+ + T L + NV +D G Y C N GS + KA L V ++ P +
Sbjct: 366 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT-KAYLEVTDVIADRPPPVIRQG 424
Query: 608 PMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKI 667
P++ T+ L C A G P P I W+KDG + ++ R+ + E+ V I K+
Sbjct: 425 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV--LVSTQDSRIKQL-ENGVLQIRYAKL 481
Query: 668 EDMGIYSCMAQNTAGGLSANASLTVLETPSFIRP 701
D G Y+C+A +G + +A + V E ++P
Sbjct: 482 GDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 515
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 128 bits (322), Expect = 3e-29
Identities = 117/478 (24%), Positives = 206/478 (43%), Gaps = 43/478 (8%)
Query: 142 FYPALESLDLSSNIISEIKTSSFPRM---QLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198
F P ++ S+ +++ +FP + L L N I +E + +L +
Sbjct: 41 FTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST--DFPVNLTGLD 98
Query: 199 LNRNRMSMIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDG 257
L++N +S + + K+P L + L+ N++ + L +L+ L + N +S + G
Sbjct: 99 LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPG 158
Query: 258 AFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELD 317
AF GL+N+ L L N L +N W L L+ L + +N I RI ++ L L
Sbjct: 159 AFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLV 218
Query: 318 LSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS----- 372
++ LT + ++A VGL LE ++ DNR+ + + + NL+ LDL N I+
Sbjct: 219 IAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRG 278
Query: 373 -----------------WAIEDASEAFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEH 414
I S A L L K+ N ++ I AF L LE
Sbjct: 279 DFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
Query: 415 LDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473
L LN+NA+ ++ S +LKE+ ++++ + CDC ++W+ + F ++ C
Sbjct: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVD 398
Query: 474 PEWLAGQSILNVDLKDF--VCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMST 531
P GQ++ V +D +C + P+ + P + G V+ C A + +
Sbjct: 399 PPEFQGQNVRQVHFRDMMEICLPLIAPE--SFPSNLNVEAGSYVSFHCRATAEPQPEIYW 456
Query: 532 VWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589
+ ++L + T+ F Y G L + V + G Y CI TN G++
Sbjct: 457 ITPSGQKLLPNTLTDKF--YVHSEG-------TLDINGVTPKEGGLYTCIATNLVGAD 505
Score = 87.4 bits (215), Expect = 6e-17
Identities = 105/451 (23%), Positives = 189/451 (41%), Gaps = 33/451 (7%)
Query: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
L +Q N I+K++ F +N + L+L NNL+ V + + L +Y+ +N + +
Sbjct: 74 LLLQTNNIAKIEYSTDFPVN-LTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELP 132
Query: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
L EL +++N L+ + AF+GL L RL+L NR+ I F L NL+
Sbjct: 133 EKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEI 192
Query: 364 LDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIM 423
L + N I I+D + F L +L L++ G + I A +GLE+LE + +N ++
Sbjct: 193 LMIGENPII-RIKDMN--FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 424 SIQENAFSQT-HLKELILNTSSL----LCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLA 478
+ A + +LK L LN + + D L+ L NN +++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
Query: 479 GQSILNVDLKDFVCDDFLKPQIR-THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDS 537
DL+ + P++ HP L + ++ + + +S ++
Sbjct: 310 -------DLRKIEATN--NPRLSYIHPNAFFRLPKLE------SLMLNSNALSALYHGTI 354
Query: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHF-GSNYSQKAKL 596
E L ++ + + + + + ++ N+ F + C+ F G N Q
Sbjct: 355 ESLPNLKEISIHSNPIRCDCVIRWMN-MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
Query: 597 TVNEMPSFL----KTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTD-FPAARERRM 651
+ E+ L P +L + G+ C A P P+I W G P +
Sbjct: 414 DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
Query: 652 HVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
+V E I V ++ G+Y+C+A N G
Sbjct: 474 YVHSE-GTLDINGVTPKEGGLYTCIATNLVG 503
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 4/147 (2%)
Query: 109 LTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM 167
LTEIP N+ +S N + ++ ALQ L+ LDL+ N I+ I+ F M
Sbjct: 224 LTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNM 283
Query: 168 -QLKYLNLSN-NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPK-IFKLPHLQFLELKR 224
LK L ++N + ++++ DNL + N R+S I P F+LP L+ L L
Sbjct: 284 LHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNS 343
Query: 225 NRIKIVEGLTFQGLDSLRSLKMQRNGI 251
N + + T + L +L+ + + N I
Sbjct: 344 NALSALYHGTIESLPNLKEISIHSNPI 370
Score = 34.3 bits (77), Expect = 0.64
Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 5/92 (5%)
Query: 707 VTRGETAVLQCIAGGSPAPRLNWTKDDG----PLLVTERHFFAAANQLLIIVDAGLEDAG 762
V G C A P P + W G P +T++ F+ + L I ++ G
Sbjct: 434 VEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDK-FYVHSEGTLDINGVTPKEGG 492
Query: 763 KYTCIMSNTLGTERGHIYLNVISSPNCDSSQS 794
YTCI +N +G + + + V S D++ S
Sbjct: 493 LYTCIATNLVGADLKSVMIKVDGSFPQDNNGS 524
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 128 bits (322), Expect = 3e-29
Identities = 117/478 (24%), Positives = 206/478 (43%), Gaps = 43/478 (8%)
Query: 142 FYPALESLDLSSNIISEIKTSSFPRM---QLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198
F P ++ S+ +++ +FP + L L N I +E + +L +
Sbjct: 41 FTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST--DFPVNLTGLD 98
Query: 199 LNRNRMSMIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDG 257
L++N +S + + K+P L + L+ N++ + L +L+ L + N +S + G
Sbjct: 99 LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPG 158
Query: 258 AFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELD 317
AF GL+N+ L L N L +N W L L+ L + +N I RI ++ L L
Sbjct: 159 AFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLV 218
Query: 318 LSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS----- 372
++ LT + ++A VGL LE ++ DNR+ + + + NL+ LDL N I+
Sbjct: 219 IAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRG 278
Query: 373 -----------------WAIEDASEAFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEH 414
I S A L L K+ N ++ I AF L LE
Sbjct: 279 DFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
Query: 415 LDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473
L LN+NA+ ++ S +LKE+ ++++ + CDC ++W+ + F ++ C
Sbjct: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVD 398
Query: 474 PEWLAGQSILNVDLKDF--VCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMST 531
P GQ++ V +D +C + P+ + P + G V+ C A + +
Sbjct: 399 PPEFQGQNVRQVHFRDMMEICLPLIAPE--SFPSNLNVEAGSYVSFHCRATAEPQPEIYW 456
Query: 532 VWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589
+ ++L + T+ F Y G L + V + G Y CI TN G++
Sbjct: 457 ITPSGQKLLPNTLTDKF--YVHSEG-------TLDINGVTPKEGGLYTCIATNLVGAD 505
Score = 87.4 bits (215), Expect = 6e-17
Identities = 105/451 (23%), Positives = 189/451 (41%), Gaps = 33/451 (7%)
Query: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
L +Q N I+K++ F +N + L+L NNL+ V + + L +Y+ +N + +
Sbjct: 74 LLLQTNNIAKIEYSTDFPVN-LTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELP 132
Query: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
L EL +++N L+ + AF+GL L RL+L NR+ I F L NL+
Sbjct: 133 EKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEI 192
Query: 364 LDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIM 423
L + N I I+D + F L +L L++ G + I A +GLE+LE + +N ++
Sbjct: 193 LMIGENPII-RIKDMN--FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 424 SIQENAFSQT-HLKELILNTSSL----LCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLA 478
+ A + +LK L LN + + D L+ L NN +++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
Query: 479 GQSILNVDLKDFVCDDFLKPQIR-THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDS 537
DL+ + P++ HP L + ++ + + +S ++
Sbjct: 310 -------DLRKIEATN--NPRLSYIHPNAFFRLPKLE------SLMLNSNALSALYHGTI 354
Query: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHF-GSNYSQKAKL 596
E L ++ + + + + + ++ N+ F + C+ F G N Q
Sbjct: 355 ESLPNLKEISIHSNPIRCDCVIRWMN-MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
Query: 597 TVNEMPSFL----KTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTD-FPAARERRM 651
+ E+ L P +L + G+ C A P P+I W G P +
Sbjct: 414 DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
Query: 652 HVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
+V E I V ++ G+Y+C+A N G
Sbjct: 474 YVHSE-GTLDINGVTPKEGGLYTCIATNLVG 503
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 4/147 (2%)
Query: 109 LTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM 167
LTEIP N+ +S N + ++ ALQ L+ LDL+ N I+ I+ F M
Sbjct: 224 LTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNM 283
Query: 168 -QLKYLNLSN-NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPK-IFKLPHLQFLELKR 224
LK L ++N + ++++ DNL + N R+S I P F+LP L+ L L
Sbjct: 284 LHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNS 343
Query: 225 NRIKIVEGLTFQGLDSLRSLKMQRNGI 251
N + + T + L +L+ + + N I
Sbjct: 344 NALSALYHGTIESLPNLKEISIHSNPI 370
Score = 34.3 bits (77), Expect = 0.64
Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 5/92 (5%)
Query: 707 VTRGETAVLQCIAGGSPAPRLNWTKDDG----PLLVTERHFFAAANQLLIIVDAGLEDAG 762
V G C A P P + W G P +T++ F+ + L I ++ G
Sbjct: 434 VEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDK-FYVHSEGTLDINGVTPKEGG 492
Query: 763 KYTCIMSNTLGTERGHIYLNVISSPNCDSSQS 794
YTCI +N +G + + + V S D++ S
Sbjct: 493 LYTCIATNLVGADLKSVMIKVDGSFPQDNNGS 524
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 128 bits (322), Expect = 3e-29
Identities = 117/478 (24%), Positives = 206/478 (43%), Gaps = 43/478 (8%)
Query: 142 FYPALESLDLSSNIISEIKTSSFPRM---QLKYLNLSNNRITTLEAGCFDNLSSSLLVVK 198
F P ++ S+ +++ +FP + L L N I +E + +L +
Sbjct: 41 FTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST--DFPVNLTGLD 98
Query: 199 LNRNRMSMIPP-KIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDG 257
L++N +S + + K+P L + L+ N++ + L +L+ L + N +S + G
Sbjct: 99 LSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYINHNLLSTISPG 158
Query: 258 AFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELD 317
AF GL+N+ L L N L +N W L L+ L + +N I RI ++ L L
Sbjct: 159 AFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNFKPLINLRSLV 218
Query: 318 LSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEIS----- 372
++ LT + ++A VGL LE ++ DNR+ + + + NL+ LDL N I+
Sbjct: 219 IAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRG 278
Query: 373 -----------------WAIEDASEAFAGLTSLTKLILQGN-QIKSITKKAFIGLESLEH 414
I S A L L K+ N ++ I AF L LE
Sbjct: 279 DFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLES 338
Query: 415 LDLNNNAIMSIQENAF-SQTHLKELILNTSSLLCDCHLKWLLQWLVDNNFQHSVNVSCAH 473
L LN+NA+ ++ S +LKE+ ++++ + CDC ++W+ + F ++ C
Sbjct: 339 LMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMNMNKTNIRFMEPDSLFCVD 398
Query: 474 PEWLAGQSILNVDLKDF--VCDDFLKPQIRTHPETIIALRGMNVTLTCTAVSSSDSPMST 531
P GQ++ V +D +C + P+ + P + G V+ C A + +
Sbjct: 399 PPEFQGQNVRQVHFRDMMEICLPLIAPE--SFPSNLNVEAGSYVSFHCRATAEPQPEIYW 456
Query: 532 VWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHFGSN 589
+ ++L + T+ F Y G L + V + G Y CI TN G++
Sbjct: 457 ITPSGQKLLPNTLTDKF--YVHSEG-------TLDINGVTPKEGGLYTCIATNLVGAD 505
Score = 87.4 bits (215), Expect = 6e-17
Identities = 105/451 (23%), Positives = 189/451 (41%), Gaps = 33/451 (7%)
Query: 244 LKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERIS 303
L +Q N I+K++ F +N + L+L NNL+ V + + L +Y+ +N + +
Sbjct: 74 LLLQTNNIAKIEYSTDFPVN-LTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELP 132
Query: 304 PDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQT 363
L EL +++N L+ + AF+GL L RL+L NR+ I F L NL+
Sbjct: 133 EKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEI 192
Query: 364 LDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIM 423
L + N I I+D + F L +L L++ G + I A +GLE+LE + +N ++
Sbjct: 193 LMIGENPII-RIKDMN--FKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLI 249
Query: 424 SIQENAFSQT-HLKELILNTSSL----LCDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLA 478
+ A + +LK L LN + + D L+ L NN +++ + L
Sbjct: 250 KVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLP 309
Query: 479 GQSILNVDLKDFVCDDFLKPQIR-THPETIIALRGMNVTLTCTAVSSSDSPMSTVWRKDS 537
DL+ + P++ HP L + ++ + + +S ++
Sbjct: 310 -------DLRKIEATN--NPRLSYIHPNAFFRLPKLE------SLMLNSNALSALYHGTI 354
Query: 538 EILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFTDEGKYQCIVTNHF-GSNYSQKAKL 596
E L ++ + + + + + ++ N+ F + C+ F G N Q
Sbjct: 355 ESLPNLKEISIHSNPIRCDCVIRWMN-MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVHFR 413
Query: 597 TVNEMPSFL----KTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTD-FPAARERRM 651
+ E+ L P +L + G+ C A P P+I W G P +
Sbjct: 414 DMMEICLPLIAPESFPSNLNVEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDKF 473
Query: 652 HVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
+V E I V ++ G+Y+C+A N G
Sbjct: 474 YVHSE-GTLDINGVTPKEGGLYTCIATNLVG 503
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 4/147 (2%)
Query: 109 LTEIPYFG-EPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM 167
LTEIP N+ +S N + ++ ALQ L+ LDL+ N I+ I+ F M
Sbjct: 224 LTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLNKNPINRIRRGDFSNM 283
Query: 168 -QLKYLNLSN-NRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPK-IFKLPHLQFLELKR 224
LK L ++N + ++++ DNL + N R+S I P F+LP L+ L L
Sbjct: 284 LHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSYIHPNAFFRLPKLESLMLNS 343
Query: 225 NRIKIVEGLTFQGLDSLRSLKMQRNGI 251
N + + T + L +L+ + + N I
Sbjct: 344 NALSALYHGTIESLPNLKEISIHSNPI 370
Score = 34.3 bits (77), Expect = 0.64
Identities = 24/92 (26%), Positives = 39/92 (42%), Gaps = 5/92 (5%)
Query: 707 VTRGETAVLQCIAGGSPAPRLNWTKDDG----PLLVTERHFFAAANQLLIIVDAGLEDAG 762
V G C A P P + W G P +T++ F+ + L I ++ G
Sbjct: 434 VEAGSYVSFHCRATAEPQPEIYWITPSGQKLLPNTLTDK-FYVHSEGTLDINGVTPKEGG 492
Query: 763 KYTCIMSNTLGTERGHIYLNVISSPNCDSSQS 794
YTCI +N +G + + + V S D++ S
Sbjct: 493 LYTCIATNLVGADLKSVMIKVDGSFPQDNNGS 524
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,226,880
Number of Sequences: 37866
Number of extensions: 1925566
Number of successful extensions: 14475
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 404
Number of HSP's successfully gapped in prelim test: 261
Number of HSP's that attempted gapping in prelim test: 5542
Number of HSP's gapped (non-prelim): 3928
length of query: 1065
length of database: 18,247,518
effective HSP length: 113
effective length of query: 952
effective length of database: 13,968,660
effective search space: 13298164320
effective search space used: 13298164320
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.