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Search of human proteins with 7662238
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
sapiens]
(1341 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 2642 0.0
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 133 1e-30
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 114 5e-25
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 114 6e-25
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 112 2e-24
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 112 3e-24
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 111 4e-24
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 111 4e-24
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 111 4e-24
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 110 9e-24
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 107 1e-22
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 105 3e-22
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 104 5e-22
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 104 6e-22
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 103 1e-21
gi|38788333 remodeling and spacing factor 1 [Homo sapiens] 102 3e-21
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 100 1e-20
gi|148746195 trichohyalin [Homo sapiens] 96 3e-19
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s... 92 3e-18
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 91 6e-18
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 91 6e-18
gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo sapi... 90 1e-17
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 86 2e-16
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 85 4e-16
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 85 4e-16
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 85 5e-16
gi|209862789 microtubule associated monoxygenase, calponin and L... 84 7e-16
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 84 1e-15
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 83 2e-15
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 83 2e-15
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
Length = 1341
Score = 2642 bits (6847), Expect = 0.0
Identities = 1341/1341 (100%), Positives = 1341/1341 (100%)
Query: 1 MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMA 60
MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMA
Sbjct: 1 MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMA 60
Query: 61 ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA 120
ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA
Sbjct: 61 ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA 120
Query: 121 FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA 180
FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA
Sbjct: 121 FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA 180
Query: 181 SLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS 240
SLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS
Sbjct: 181 SLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS 240
Query: 241 EGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI 300
EGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI
Sbjct: 241 EGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI 300
Query: 301 LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE 360
LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE
Sbjct: 301 LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE 360
Query: 361 MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT 420
MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT
Sbjct: 361 MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT 420
Query: 421 KEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL 480
KEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL
Sbjct: 421 KEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL 480
Query: 481 SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK 540
SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK
Sbjct: 481 SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK 540
Query: 541 GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG 600
GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG
Sbjct: 541 GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG 600
Query: 601 SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGV 660
SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGV
Sbjct: 601 SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGV 660
Query: 661 SRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT 720
SRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT
Sbjct: 661 SRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT 720
Query: 721 QRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR 780
QRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR
Sbjct: 721 QRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR 780
Query: 781 PENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT 840
PENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT
Sbjct: 781 PENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT 840
Query: 841 EGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED 900
EGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED
Sbjct: 841 EGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED 900
Query: 901 ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVAL 960
ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVAL
Sbjct: 901 ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVAL 960
Query: 961 PPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLV 1020
PPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLV
Sbjct: 961 PPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLV 1020
Query: 1021 RPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK 1080
RPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK
Sbjct: 1021 RPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK 1080
Query: 1081 FLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER 1140
FLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER
Sbjct: 1081 FLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER 1140
Query: 1141 AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE 1200
AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE
Sbjct: 1141 AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE 1200
Query: 1201 KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ 1260
KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ
Sbjct: 1201 KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ 1260
Query: 1261 KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD 1320
KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD
Sbjct: 1261 KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD 1320
Query: 1321 TKRHSRSRSRSTPVRDRGGRR 1341
TKRHSRSRSRSTPVRDRGGRR
Sbjct: 1321 TKRHSRSRSRSTPVRDRGGRR 1341
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 133 bits (335), Expect = 1e-30
Identities = 90/250 (36%), Positives = 131/250 (52%), Gaps = 25/250 (10%)
Query: 1102 RPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRS 1161
R E KTE++ R + + R Q ++ER R++ ERERE + S
Sbjct: 195 REKENKTEDRHSERGRERERERETET-ETERKRQTDRERD-RQRKTEREREKQAERERAS 252
Query: 1162 EREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAA 1221
ERE +RDK RE R R R RDRR+KER + ++K +++ + E K R+ +
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER- 311
Query: 1222 PCIYWLPLTDSQIVQKEAERAERAKEREKRR-----KEQEEEEQKEREKEAERERNRQLE 1276
+ ++E ER ER +ERE++R +E+E E +++R+ E +RERNRQ
Sbjct: 312 ----------ERNRKRERER-ERERERERQRETERDREKERERKRKRQTEMDRERNRQTG 360
Query: 1277 REKRREHSRERDRERE------RERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSR 1330
RE RR+ RER+RERE RERE DRDRDR+++RER E+DR + + R R
Sbjct: 361 REGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQRER 420
Query: 1331 STPVRDRGGR 1340
GR
Sbjct: 421 EKDRESERGR 430
Score = 123 bits (309), Expect = 1e-27
Identities = 82/225 (36%), Positives = 122/225 (54%), Gaps = 22/225 (9%)
Query: 1129 QHPRAEQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSR------ 1181
+ R +RE ER R+ +RERE +R ER+ DR++ R+ R+R + R
Sbjct: 126 ERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNR 185
Query: 1182 -DRRRKERAKSKEKKSEKK--EKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKE 1238
+RR +ER + KE K+E + E+ +E + + + + + +K+
Sbjct: 186 QERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQ 245
Query: 1239 AERAERAKEREKRRKEQEEEE----------QKEREKEAERERNRQLEREKRREHSRERD 1288
AER ERA ERE R ++ E E QKERE++ +R+R R+ ER++ E RER
Sbjct: 246 AER-ERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ 304
Query: 1289 RERERERERDR-GDRDRDRERDRERGRERDRRDTKRHSRSRSRST 1332
RERERERER+R +R+R+RER+RER RE +R K R R R T
Sbjct: 305 RERERERERNRKRERERERERERERQRETERDREKERERKRKRQT 349
Score = 123 bits (309), Expect = 1e-27
Identities = 75/204 (36%), Positives = 123/204 (60%), Gaps = 23/204 (11%)
Query: 1135 QREQERAV---REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDR-RRKERAK 1190
Q+E+ER R++ ER+RE ER+ + ERE +R++ R+ R R R R+R R++E +
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETER 335
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK 1250
+EK+ E+K K Q E + R+ + Q E ER ER +ER++
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRR---------------QAERER-ERERERDR 379
Query: 1251 RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDR 1310
+ + EE +++R+++ ++ER RQ E+++ + E+ RERE++RE +RG R+R RER++
Sbjct: 380 QSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERG-RERGREREK 438
Query: 1311 ERGRERDR-RDTKRHS-RSRSRST 1332
++GRERDR R T R + R R RST
Sbjct: 439 QKGRERDRERQTDRQAGRQRKRST 462
Score = 117 bits (294), Expect = 6e-26
Identities = 77/212 (36%), Positives = 111/212 (52%), Gaps = 21/212 (9%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRK-ERAK 1190
R QRE+E ++ +ER RE ER T +E E R RE R R R+R ++ ER +
Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERER 250
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK 1250
+ E+++E+ ++ + E D +K + + Q +K R ER +E E+
Sbjct: 251 ASERETERDKERERERDRDRDRDRRQKER-----------ERQTDRKRQRRTERDRETER 299
Query: 1251 RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDR-GDRDRDRERD 1309
+R+ Q RE+E ERERNR+ ERE+ RE RER RE ER+RE++R R R E D
Sbjct: 300 KRERQ-------RERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352
Query: 1310 RERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
RER R+ R ++ R R R RDR R
Sbjct: 353 RERNRQTGREGRRQAERERERERE-RDRQSAR 383
Score = 117 bits (293), Expect = 7e-26
Identities = 77/223 (34%), Positives = 119/223 (53%), Gaps = 31/223 (13%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRD-RRRKERAK 1190
R QR++E+ RE+ +RER+ +R + ++E +R+ REG R R R D +R +ER +
Sbjct: 95 RERQRDREKE-RERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK 1250
EK+ E++ + + + R+ + + ER ER ++REK
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKERERE----------------KNRQERRERERQREK 197
Query: 1251 ------RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERER---DRGD 1301
R E+ E ++ERE E E ER RQ +RE+ R+ ER+RE++ ERER +
Sbjct: 198 ENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 1302 RDRDRERDRERGRERDRRDTKRH---SRSRSRSTPVRDRGGRR 1341
RD++RER+R+R R+RDRR +R R R R T RDR R
Sbjct: 258 RDKERERERDRDRDRDRRQKERERQTDRKRQRRTE-RDRETER 299
Score = 116 bits (291), Expect = 1e-25
Identities = 66/199 (33%), Positives = 114/199 (57%), Gaps = 22/199 (11%)
Query: 1143 REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDR---RRKERAKSKEKKSEKK 1199
RE+ ++ERE RRE+ ++ERE DR + R + R R RDR R+++R K +E++++++
Sbjct: 54 RERNRQKERE-RRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRE 112
Query: 1200 EKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEE 1259
Q E + R+T ++E ER + +R +E++ +
Sbjct: 113 RDRQREKERNRQKERERET-----------------EREGERGRDRQTDGQRERERQRDA 155
Query: 1260 QKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDR- 1318
+KERE++ +RER RQ ER +++E RE++R+ RERER R ++ +R ERGRER+R
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 1319 RDTKRHSRSRSRSTPVRDR 1337
R+T+ + + ++ RDR
Sbjct: 216 RETETETERKRQTDRERDR 234
Score = 115 bits (287), Expect = 4e-25
Identities = 79/221 (35%), Positives = 118/221 (53%), Gaps = 33/221 (14%)
Query: 1129 QHPRAEQREQERAVREQWA---EREREMERRERTR-----SEREWDRDKVREGPRSRSRS 1180
Q R Q+E+ER Q ER+RE E + R ERE +R+ E R R
Sbjct: 170 QTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTD 229
Query: 1181 RDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAE 1240
R+R R+ + + + +K ++E+A E + D R+ + ++ +
Sbjct: 230 RERDRQRKTEREREKQAERERASERETER---DKERERER---------------DRDRD 271
Query: 1241 RAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRG 1300
R R KERE R+ +++ + + ER++E ER+R RQ ERE+ RE +R+R+RERERERER
Sbjct: 272 RDRRQKERE-RQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERER--- 327
Query: 1301 DRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
+R R+ ERDRE+ RER R+ R R+R T R GRR
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQT---GREGRR 365
Score = 90.9 bits (224), Expect = 7e-18
Identities = 57/190 (30%), Positives = 98/190 (51%), Gaps = 23/190 (12%)
Query: 1155 RRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDL 1214
RR ++ ++ D D + R+R + R+RRR++R +++ + K+E+ +E+ + D
Sbjct: 39 RRGLGQAHKDADGD---DRERNRQKERERRREKR-QTERETDRKRERRREKDRHRKRDRH 94
Query: 1215 FRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAER--ERN 1272
+ + +E ER + R++E+E QKERE+E ER ER
Sbjct: 95 RERQR----------------DREKERERQTDRERDRQREKERNRQKERERETEREGERG 138
Query: 1273 RQLEREKRREHSRERDRERERERERDR-GDRDRDRERDRERGRERDRRDTKRHSRSRSRS 1331
R + + +RE R+RD E+ERER+ DR R +R R +ER RE++R++ + R R +
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKE 198
Query: 1332 TPVRDRGGRR 1341
DR R
Sbjct: 199 NKTEDRHSER 208
Score = 67.8 bits (164), Expect = 7e-11
Identities = 111/522 (21%), Positives = 184/522 (35%), Gaps = 58/522 (11%)
Query: 204 RKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRA 263
+K EK ++ E RK ERR + R + + E + E+E +++T R R
Sbjct: 59 QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118
Query: 264 DRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDER 323
+ +E E E E E E + + D GQ+ RE R + E ER
Sbjct: 119 KERNRQKERERETEREGERGRDRQTD--GQRERE---------------RQRDAEKERER 161
Query: 324 PKTRSQEQEVLERGGRFTRSQEEARKSHLARQ-QQEKEMKTTSPLEEEEREIKSSQGLKE 382
R ++++ ER + R +E+ R+ R+ Q+EKE KT E RE + + +
Sbjct: 162 QTDRERQRQT-ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETET 220
Query: 383 KSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPME 442
++ +RK+ + Q +E E + AS E E +
Sbjct: 221 ET----------ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERD--- 267
Query: 443 GPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLP 502
+ D D R+ + T + + ++ K E E+ E
Sbjct: 268 ------------RDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNR 315
Query: 503 LVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASH 562
++ + ++ E E DR E K TE ++ +EGRR +
Sbjct: 316 KRERERERERERERQRETERDREK-------ERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 563 TLLPSHRL--KQSADSSSSRSSSSSSSSSRSRSR--SPDSSGSRSHSPLRSKQRDVAQAR 618
R +QSA R + R R D G R R +++D R
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESER 428
Query: 619 THANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSG- 677
R R K R R R R ++ P + S ++ P+ G
Sbjct: 429 GRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGI 488
Query: 678 QEVATPPVPQLQVCE-PKERTSTSS-SSVQARRLSQPESAEK 717
+ ++P P+ P R + +S V RR +P EK
Sbjct: 489 RWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEK 530
Score = 66.6 bits (161), Expect = 2e-10
Identities = 77/302 (25%), Positives = 128/302 (42%), Gaps = 28/302 (9%)
Query: 124 NSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELE-EASAESEDEMIHPEGVASL 182
N Q E +N ++ E+Q+E + +R + E E E E+E E
Sbjct: 174 NRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRER- 232
Query: 183 LPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEG 242
D Q ER E + + R+ +S E + D + E+ R +R R RQ + ++
Sbjct: 233 ---DRQRKTER---EREKQAERERASERETERDKERERERDRDRDRDR-RQKERERQTDR 285
Query: 243 SQPAEEEEDQETPSRNLRVRA-----DRNLKTEEEEEEEEEEE---EDDEEEEGDDEGQK 294
+ E D+ET + R R +RN K E E E E E E E + + E + E ++
Sbjct: 286 KRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKR 345
Query: 295 SREAPILKE-FKEEGEEIPRVKPEEMMDERPKTR--SQEQEVLERGGRFTRSQEEARKSH 351
R+ + +E ++ G E R E ER + R ++E+E ER R +E R++
Sbjct: 346 KRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTE 405
Query: 352 LARQQQ---EKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE-----DRKKASLVA 403
R Q EK+ + E E + + K+K + R T+ RK+++L
Sbjct: 406 KDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYV 465
Query: 404 LP 405
P
Sbjct: 466 NP 467
Score = 64.3 bits (155), Expect = 7e-10
Identities = 49/157 (31%), Positives = 83/157 (52%), Gaps = 20/157 (12%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKER 1188
+ R +RE++R E+ E+ERE +R+ +T +RE +R REG R R R+R R ER
Sbjct: 320 ERERERERERQRET-ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERER-ER 377
Query: 1189 AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQ---KEAERA-ER 1244
+ ++ E++E+ ++ K + K + T+ Q + +E+ER ER
Sbjct: 378 DRQSAREREERERDRDRDRQKERERQTEKDRDGQ-----RETEKQREREKDRESERGRER 432
Query: 1245 AKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRR 1281
+EREK QK RE++ ER+ +RQ R+++R
Sbjct: 433 GREREK---------QKGRERDRERQTDRQAGRQRKR 460
Score = 58.9 bits (141), Expect = 3e-08
Identities = 50/225 (22%), Positives = 95/225 (42%), Gaps = 14/225 (6%)
Query: 197 ELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE----EDQ 252
E RH RK E + D + E+ R+ +R R R+ + E + E E D+
Sbjct: 84 EKDRH--RKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 253 ETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIP 312
+T + R R K E + + E + + + + + E +K+R+ +E + E E
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKEN-- 199
Query: 313 RVKPEEMMDERPKTRSQEQEV---LERGGRFTRSQEEARKSHLARQQQ-EKEMKTTSPLE 368
K E+ ER + R +E+E ER + R ++ RK+ R++Q E+E + E
Sbjct: 200 --KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 369 EEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEE 413
++ + +++ + DRK+ +T + E
Sbjct: 258 RDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302
Score = 58.5 bits (140), Expect = 4e-08
Identities = 64/281 (22%), Positives = 112/281 (39%), Gaps = 27/281 (9%)
Query: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201
E+Q + R R + R + E E E E + Q E+ E R
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEK---ERERQ 162
Query: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSE---GSQPAEEEEDQETPSRN 258
+ R+ +E + E+ + + R R RQ +E + E E ++ET +
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222
Query: 259 LRVRA-----DRNLKTEEEEEEEEEEEEDDEEE-EGDDEGQKSREAPILKEFKEEGEE-- 310
R R DR KTE E E++ E E E E E D E ++ R+ ++ +++ E
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQ 282
Query: 311 --------IPRVKPEEMMDERPKTRSQEQE---VLERGGRFTRSQEEARKSHLARQ-QQE 358
R + E ER + R +E+E ER R +E R++ R+ ++E
Sbjct: 283 TDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERE 342
Query: 359 KEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKA 399
++ K + ++ E +G ++ + R DR+ A
Sbjct: 343 RKRKRQTEMDRERNRQTGREGRRQAERERERER-ERDRQSA 382
Score = 56.6 bits (135), Expect = 2e-07
Identities = 57/261 (21%), Positives = 107/261 (40%), Gaps = 13/261 (4%)
Query: 149 RQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSS 208
RQR + RE E + E E + + + +R + + R R+ +
Sbjct: 97 RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR-QTDGQRERERQRDA 155
Query: 209 ISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLK 268
E + +D E+ R+ ER + R+ + + + E++ +T R+ +R +
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 269 TEEEEEEEEEEEEDDEEE-----EGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDER 323
E E E E + + D E + E + E Q RE +E + + E + D R
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 324 PKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEERE-----IKSSQ 378
K R ++ + +R R R +E RK R+++ + + E ERE + ++
Sbjct: 276 QKERERQTD-RKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 379 GLKEKSKSPSPPRLTE-DRKK 398
+EK + R TE DR++
Sbjct: 335 RDREKERERKRKRQTEMDRER 355
Score = 52.4 bits (124), Expect = 3e-06
Identities = 41/191 (21%), Positives = 76/191 (39%), Gaps = 2/191 (1%)
Query: 195 ELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQET 254
E E R R+ K D E+ R E+ R + E + ++E ++ET
Sbjct: 72 ERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERET 131
Query: 255 PSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRV 314
R R + E E + + E+E E + D E Q+ E KE + E R
Sbjct: 132 EREGERGRDRQTDGQRERERQRDAEKE--RERQTDRERQRQTERNRQKEREREKNRQERR 189
Query: 315 KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREI 374
+ E ++ KT + E R ++ E + ++++++ KT E++
Sbjct: 190 ERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERE 249
Query: 375 KSSQGLKEKSK 385
++S+ E+ K
Sbjct: 250 RASERETERDK 260
Score = 46.6 bits (109), Expect = 2e-04
Identities = 35/121 (28%), Positives = 57/121 (47%), Gaps = 7/121 (5%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSER--EWDRDKVREGPRSRSRSRDRRRK 1186
+ R +RE++R + ERER+ +R + ER E DRD RE + R R +D R
Sbjct: 368 ERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKD-RES 426
Query: 1187 ERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLP---LTDSQIVQKEAERAE 1243
ER + + ++ E K+K +E + D + + +Y P S +VQ + R
Sbjct: 427 ERGRERGRERE-KQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPT 485
Query: 1244 R 1244
R
Sbjct: 486 R 486
Score = 39.7 bits (91), Expect = 0.020
Identities = 43/238 (18%), Positives = 72/238 (30%), Gaps = 9/238 (3%)
Query: 554 QKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRD 613
QKE R + + + R R R + R R +QR+
Sbjct: 59 QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118
Query: 614 VAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKD 673
+ R R + G R R R R + + R T K+
Sbjct: 119 KERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE 178
Query: 674 PSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKC 733
+E + + KE + S + R + E ++ Q +R ++
Sbjct: 179 RE--REKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQR 236
Query: 734 EAEEAEPPAATQPQTSETQTSHLPESERIH-------HTVEEKEEVTMDTSENRPEND 784
+ E A + + SE +T E ER +E+E T + R E D
Sbjct: 237 KTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERD 294
Score = 39.3 bits (90), Expect = 0.026
Identities = 22/68 (32%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 1275 LEREKRREHSRERDRERER-ERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTP 1333
L+ +RR S+E R R + +D DR+R R +ER R R++R T+R + +
Sbjct: 24 LDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRR 83
Query: 1334 VRDRGGRR 1341
+DR +R
Sbjct: 84 EKDRHRKR 91
Score = 39.3 bits (90), Expect = 0.026
Identities = 63/378 (16%), Positives = 125/378 (33%), Gaps = 37/378 (9%)
Query: 571 KQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMG 630
++ D R + + R R + G R QR+ + R R R
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165
Query: 631 SRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQV 690
R R+R + R R + R+ +++ TE + G+E
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENK---TEDRHSERGRE----------- 211
Query: 691 CEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSE 750
+ER + + + +R + E + T+R + ++ ++ E E + +
Sbjct: 212 ---RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDR 268
Query: 751 TQTSHLPESERIHHTVEEKEEVT-MDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDE 809
+ + ER T +++ T D R E + E E E
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE 328
Query: 810 EKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTE 869
++E+ + +R+ T+ N T G+ GR R+ +++ S
Sbjct: 329 RQRETERDREKERERKRKRQTEMDRERNRQT--GREGR-RQAERERERERERDRQSARER 385
Query: 870 SLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEG 929
+ D +E + D R +E + ER D + G
Sbjct: 386 EERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESE----------------RG 429
Query: 930 QENGQREEEEEEKEPEAE 947
+E G+ E+++ +E + E
Sbjct: 430 RERGREREKQKGRERDRE 447
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 114 bits (286), Expect = 5e-25
Identities = 71/213 (33%), Positives = 115/213 (53%), Gaps = 21/213 (9%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKER 1188
+ R +R++ER +E+ R R+ E++ +RE ++ K RE R R R R+R R +R
Sbjct: 91 ERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDR-DR 149
Query: 1189 AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKER 1248
K +E+++EK Q E + D R+ QKE E ER ++R
Sbjct: 150 EKERERQTEKDRDGQRETETERERDREREK-----------------QKERE-TERDRDR 191
Query: 1249 EKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRER 1308
+ R E+E E Q +RE++ +R+ + +RE RE RE DR RER+R+RDRG ++RDRER
Sbjct: 192 Q-RDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRG-KERDRER 249
Query: 1309 DRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
DR+ R+++R+ ++ R + R +R
Sbjct: 250 DRKEERKKERKKERKKERKEKKKEEKRREDKKR 282
Score = 112 bits (281), Expect = 2e-24
Identities = 74/205 (36%), Positives = 120/205 (58%), Gaps = 32/205 (15%)
Query: 1135 QREQERAVREQWAEREREMER---RERTRSEREWDRDKVREGPRSRSRSRDR-----RRK 1186
QRE++R VRE+ E+ER+ +R RER R E+E +R++ RE R R+R R +
Sbjct: 78 QRERDR-VREK-TEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRER 135
Query: 1187 ERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAK 1246
ER + +E++ ++ + + E + D R+T E ER ER +
Sbjct: 136 ERDRGRERERDRDREKERERQTEKDRDGQRET-------------------ETER-ERDR 175
Query: 1247 EREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDR-GDRDRD 1305
EREK +KE+E E ++R+++ E+ER RQ +RE+ R+ + +R+RE +RE +R DR R+
Sbjct: 176 EREK-QKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRE 234
Query: 1306 RERDRERGRERDRRDTKRHSRSRSR 1330
R+RDR+RG+ERDR ++ R + R
Sbjct: 235 RQRDRDRGKERDRERDRKEERKKER 259
Score = 93.2 bits (230), Expect = 1e-18
Identities = 59/188 (31%), Positives = 99/188 (52%), Gaps = 26/188 (13%)
Query: 1161 SEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKK---EKAQEEPPAKLLDDLFRK 1217
S R W + + R R+R R KE+ ++K E+ ++E D ++
Sbjct: 59 SPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQ 118
Query: 1218 TKAAPCIYWLPLTDSQIVQKEAER-AERAKEREK---RRKEQEEEEQKEREKEAERERNR 1273
T+ ++++ ER ++ +ERE+ R +E++ + +KERE++ E++R+
Sbjct: 119 TE---------------IERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDG 163
Query: 1274 QLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTP 1333
Q E E RE RER++++ERE ERDR DR RD E++RER +R+R ++ R R T
Sbjct: 164 QRETETERERDREREKQKERETERDR-DRQRDTEKERERQTDRERDRQRKTQTERQRET- 221
Query: 1334 VRDRGGRR 1341
DR G R
Sbjct: 222 --DREGER 227
Score = 57.0 bits (136), Expect = 1e-07
Identities = 37/135 (27%), Positives = 67/135 (49%), Gaps = 35/135 (25%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR-KE 1187
+ R QR+ E+ RE+ +RER+ +R+ +T +RE DR+ RE R R R RDR R KE
Sbjct: 186 ERDRDRQRDTEKE-RERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKE 244
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKE 1247
R + +++K E+K++ + KE ++ + K+
Sbjct: 245 RDRERDRKEERKKERK---------------------------------KERKKERKEKK 271
Query: 1248 REKRRKEQEEEEQKE 1262
+E++R+E ++ + E
Sbjct: 272 KEEKRREDKKRKWGE 286
Score = 55.1 bits (131), Expect = 5e-07
Identities = 44/206 (21%), Positives = 88/206 (42%), Gaps = 27/206 (13%)
Query: 193 RPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQ 252
R E E +R+ R+ + E + + +K R+ ER R R+ + E + E++ D
Sbjct: 104 RKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDG 163
Query: 253 ETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIP 312
+ + R R DR E E+++E E E D + + D E ++ R+
Sbjct: 164 QRETETERER-DR-----EREKQKERETERDRDRQRDTEKERERQT-------------- 203
Query: 313 RVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEER 372
+ D + KT+++ Q +R G + + R+ + + KE +EE +
Sbjct: 204 ----DRERDRQRKTQTERQRETDREG---ERETDRRRERQRDRDRGKERDRERDRKEERK 256
Query: 373 EIKSSQGLKEKSKSPSPPRLTEDRKK 398
+ + + KE+ + + ED+K+
Sbjct: 257 KERKKERKKERKEKKKEEKRREDKKR 282
Score = 47.0 bits (110), Expect = 1e-04
Identities = 29/71 (40%), Positives = 42/71 (59%), Gaps = 4/71 (5%)
Query: 1268 ERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRS 1327
E R+ L + + +R RER+R RE+ +RDRDR+RDRE R R ++T R +R
Sbjct: 58 ESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRE--RRRKEKETNR-NRD 114
Query: 1328 RSRSTPV-RDR 1337
R + T + RDR
Sbjct: 115 REKQTEIERDR 125
Score = 42.0 bits (97), Expect = 0.004
Identities = 36/165 (21%), Positives = 71/165 (43%), Gaps = 9/165 (5%)
Query: 126 QIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPP 185
Q G E ++ ++ ++ +E R+R + R+ E E + E + +
Sbjct: 130 QKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDR 189
Query: 186 DFQSSLERP-ELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQ 244
D Q E+ E + R R+ + +E + ++D E R+ +RR R R K + +
Sbjct: 190 DRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRER 249
Query: 245 PAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGD 289
+EE +E R K +E+++EE+ ED + + G+
Sbjct: 250 DRKEERKKE--------RKKERKKERKEKKKEEKRREDKKRKWGE 286
Score = 41.6 bits (96), Expect = 0.005
Identities = 40/186 (21%), Positives = 74/186 (39%), Gaps = 14/186 (7%)
Query: 217 DDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE 276
D + R G + S R A + E D+ DR E +E+
Sbjct: 48 DFSRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEK 107
Query: 277 EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLER 336
E D E++ + E + RE K++G E R + E ER + R +E+E
Sbjct: 108 ETNRNRDREKQTEIERDRERE-------KQKGRERERDRGRER--ERDRDREKERERQTE 158
Query: 337 GGRFTRSQEEARKSHLARQQQEKEMKTTSPLE-----EEEREIKSSQGLKEKSKSPSPPR 391
R + + E + ++++KE +T + E+ERE ++ + + K+ + +
Sbjct: 159 KDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQ 218
Query: 392 LTEDRK 397
DR+
Sbjct: 219 RETDRE 224
Score = 37.7 bits (86), Expect = 0.075
Identities = 29/101 (28%), Positives = 48/101 (47%), Gaps = 25/101 (24%)
Query: 1101 DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTR 1160
DR +T+TE Q + R +RE +R RE+ +R+R ER +R R
Sbjct: 208 DRQRKTQTERQR----------------ETDREGERETDRR-RERQRDRDRGKER-DRER 249
Query: 1161 SEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
+E E + R + R + RKE+ K ++++ +KK K
Sbjct: 250 DRKE-------ERKKERKKERKKERKEKKKEEKRREDKKRK 283
Score = 35.8 bits (81), Expect = 0.28
Identities = 34/186 (18%), Positives = 62/186 (33%), Gaps = 3/186 (1%)
Query: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQR 612
E+ E R R ++ +++ +R + R R R R R ++R
Sbjct: 86 EKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERER 145
Query: 613 DVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETK 672
D + + + + G R T R R R R + + + RD+
Sbjct: 146 DRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDR--QRDTEKERERQT 203
Query: 673 DPSSGQEVATPPVPQLQVCEPKER-TSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPK 731
D ++ T Q + ER T + R + E+ + + ER +
Sbjct: 204 DRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKER 263
Query: 732 KCEAEE 737
K E +E
Sbjct: 264 KKERKE 269
Score = 32.0 bits (71), Expect = 4.1
Identities = 29/144 (20%), Positives = 46/144 (31%), Gaps = 20/144 (13%)
Query: 511 DYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRL 570
D +++ + E DR Q E + E KQ E + R
Sbjct: 148 DREKERERQTEKDRDGQ------RETETERERDREREKQKERETERDRDRQRDT------ 195
Query: 571 KQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMG 630
++ + + R + R R D G R R +QRD RG+ +
Sbjct: 196 EKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRD--------RDRGKERDR 247
Query: 631 SRSTSESRSRSRSRSRSASSNSRK 654
R E R + R + R +K
Sbjct: 248 ERDRKEERKKERKKERKKERKEKK 271
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 114 bits (285), Expect = 6e-25
Identities = 79/250 (31%), Positives = 122/250 (48%), Gaps = 39/250 (15%)
Query: 1086 YAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQP--PQHPRAEQREQERAVR 1143
Y E+D D R +R + R P P Q + R E+RE+ R R
Sbjct: 608 YPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDR 667
Query: 1144 EQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR---KERAKSKEKKSEKKE 1200
+ R+ RER R ERE DR++ RE R R R R++ R +ERA+ +E++ EK+
Sbjct: 668 ---VDDRRDERARERDR-ERERDRERERERERERDREREKERELERERAREREREREKER 723
Query: 1201 KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ 1260
+ + ++ +R ER +ERE+ R+++ E E+
Sbjct: 724 DRERDR-----------------------------DRDHDR-ERERERERDREKERERER 753
Query: 1261 KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD 1320
+ERE+E ERER R+ ERE+ RE +RERD+ERER+R+ + D+ RD R++ DR
Sbjct: 754 EERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNP 813
Query: 1321 TKRHSRSRSR 1330
H +S+
Sbjct: 814 RDGHDERKSK 823
Score = 111 bits (277), Expect = 5e-24
Identities = 70/214 (32%), Positives = 105/214 (49%), Gaps = 27/214 (12%)
Query: 1128 PQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKE 1187
P+ R +R+ R+ ER R R + +R R+ RD RR+E
Sbjct: 603 PERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREE 662
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERA-ERAK 1246
R + + E+A+E + D ++E ER ER +
Sbjct: 663 RRVDRVD-DRRDERARERDRERERDR----------------------ERERERERERDR 699
Query: 1247 EREKRR---KEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRD 1303
EREK R +E+ E ++EREKE +RER+R + ++ RE RERDRE+ERERER+ +R+
Sbjct: 700 EREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERE 759
Query: 1304 RDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
R+RER+RER RER+R + + R R D+
Sbjct: 760 RERERERERERERERERARERDKERERQRDWEDK 793
Score = 109 bits (272), Expect = 2e-23
Identities = 76/217 (35%), Positives = 110/217 (50%), Gaps = 43/217 (19%)
Query: 1126 QPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR 1185
Q P P Q + R++ E ER ++R + R ER +RD+ RE R R R R+R R
Sbjct: 639 QRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDRERERDRERERERERER 697
Query: 1186 KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERA 1245
+R + KE++ E++ + E ER
Sbjct: 698 -DREREKERELERERARERE------------------------------------RERE 720
Query: 1246 KEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRD 1305
KER++ R +++ + +ERE+E ER+R ++ ERE R E RER+RERERERER+R +R+R
Sbjct: 721 KERDRER-DRDRDHDRERERERERDREKERERE-REERERERERERERERERER-ERERA 777
Query: 1306 RERDRERGRERD--RRDTKRHSRSRSRSTPVRDRGGR 1340
RERD+ER R+RD +D R R R DR R
Sbjct: 778 RERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814
Score = 108 bits (270), Expect = 3e-23
Identities = 245/1207 (20%), Positives = 410/1207 (33%), Gaps = 230/1207 (19%)
Query: 176 PEGVASLLPPDFQSSLERPELELS----RHSPRKSSSISEEKGDSDDEKPRKGERRSSRV 231
P +L PP +S+ P LS + SP + S EKG D E+ + R
Sbjct: 357 PSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHER 416
Query: 232 RQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDE 291
R+ K EE E ++ S + R DR E + + D + E
Sbjct: 417 REDTRGKRDREKDSREEREYEQDQSSSRDHRDDR-------EPRDGRDRRDARDTRDRRE 469
Query: 292 GQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQE-QEVLERGGRFTRSQEEAR-- 348
+ SR+ +E ++ + +E D R +++ + +R GR T +E+
Sbjct: 470 LRDSRDMRDSREMRDYSRDT-----KESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPE 524
Query: 349 ------KSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLV 402
++HL + E++ S E EI++ + + + + P P + S +
Sbjct: 525 ESRSYGRNHLREESSRTEIRNESR-NESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQI 583
Query: 403 ALPEQTAS------------EEETPPPLLTKEASSPPPHPQLHSEEEI----EPMEGPAP 446
++ E + P ++ + + H E + E + P+
Sbjct: 584 DSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSS 643
Query: 447 PVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQK 506
P+ Q + D R + V V D + E E+ E
Sbjct: 644 PIRHQGRNDELERDERR---EERRVDRV---------DDRRDERARERDRERE------- 684
Query: 507 STLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLP 566
D +++ E E DR + K EL + E ++ +++ R H
Sbjct: 685 ---RDRERERERERERDRERE----KERELERERAREREREREKERDRERDRDRDH---- 733
Query: 567 SHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGR 626
D R R R R R R ++R+ + R R R
Sbjct: 734 --------DRERERERERDREKERERERE-----ERERERERERERERERERERERARER 780
Query: 627 PKMGSRSTS-ESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPV 685
K R E + + R R R+ +P D S ++ S P
Sbjct: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGS-------PS 833
Query: 686 PQLQVCEPKERTSTSSSSVQARRLSQPESAEKH--VTQRLQPERGSPKKCEAEEAEPPAA 743
P+ PK R S S S + EKH ++Q ++P+ E+ P
Sbjct: 834 PRQS---PKRRREHSPDSDAYN--SGDDKNEKHRLLSQVVRPQ-------ESRSLSPSHL 881
Query: 744 TQPQTS----ETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQV--- 796
T+ + E + ES R + E KE+V+ + R + ++ E A +
Sbjct: 882 TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS-SVDKQREQTEILESSRMRAQDIIGH 940
Query: 797 --SNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT--EGGQPGRKRRWG 852
S D DE KK++ + K +K G+ GN +T E GQ ++
Sbjct: 941 HQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDV--GIERGNIETTSEDGQVFSPKKG- 997
Query: 853 ASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHD 912
QKK SI + K DS IS++E +
Sbjct: 998 ------QKKKSIEKKRKKSKG--------------------DSDISDEEAAQQSKKKRGP 1031
Query: 913 KGLKICRTVTQVVPAEGQENGQREEEEEEKEPE----AEPPVPPQVSVEVALPPPAEHEV 968
+ I T ++V +NG E+ +++++ ++ VP + V AEH
Sbjct: 1032 RTPPIT-TKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVT-----EAEHTA 1085
Query: 969 KKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQL 1028
T G T P+ + P PP + + P TL
Sbjct: 1086 TATTPGST-----------------PSPLSSLLPPPPP------VATATATTVPATLAAT 1122
Query: 1029 KELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAE 1088
+ + A I + T +T + R P D
Sbjct: 1123 TAAAATSFST--SAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQH 1180
Query: 1089 QDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAE 1148
+ +D R + ++ G R P H + + + V
Sbjct: 1181 RKPMDQKRSSSLGSNRSNRSHTSGRLRS-------PSNDSAHRSGDDQSGRKRVLHS-GS 1232
Query: 1149 REREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPA 1208
R+RE + ER+ D+++ G SRS S DR+ R+ S + S
Sbjct: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQ-DSRSHSSRRSS------------ 1279
Query: 1209 KLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAE 1268
P +D Q+ + R + +E+ R E + E ++ER +
Sbjct: 1280 -------------------PESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ 1320
Query: 1269 RERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDR------ERGRERDRRDTK 1322
RE +R +++ R R+R RERERERERD+ RD DRER+R ER R+RDR T
Sbjct: 1321 REWDRDADKDWPRNRDRDRLRERERERERDK-RRDLDRERERLISDSVERDRDRDRDRTF 1379
Query: 1323 RHSRSRS 1329
S+ S
Sbjct: 1380 ESSQIES 1386
Score = 86.3 bits (212), Expect = 2e-16
Identities = 72/269 (26%), Positives = 121/269 (44%), Gaps = 50/269 (18%)
Query: 1095 HRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREME 1154
H+G + + + EE+ + R V + RA +R++ER R++ ERERE E
Sbjct: 647 HQGRNDELERDERREERRVDR---------VDDRRDERARERDRERE-RDRERERERERE 696
Query: 1155 RRERTRSEREWDRDKVREGPRSRSRSRDRRR-------KERAKSKEKKSEKKEKAQEEPP 1207
R ERE +R++ RE R R + RDR R +ER + +E+ EK+ + + E
Sbjct: 697 RDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREER 756
Query: 1208 AKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEA 1267
+ + + + ++E ER ERA+ER+K R+ Q + E K++ ++
Sbjct: 757 ERERERERERER----------------ERERER-ERARERDKERERQRDWEDKDKGRDD 799
Query: 1268 ERERNRQL--EREKRREHSRERDRERERER----ERDRGDRDRDRERDRERGRERDRRDT 1321
RE+ ++ +R R H + ++R R R R R+ D + D ++
Sbjct: 800 RREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNE 859
Query: 1322 K----------RHSRSRSRSTPVRDRGGR 1340
K + SRS S S DR GR
Sbjct: 860 KHRLLSQVVRPQESRSLSPSHLTEDRQGR 888
Score = 82.4 bits (202), Expect = 3e-15
Identities = 241/1275 (18%), Positives = 432/1275 (33%), Gaps = 259/1275 (20%)
Query: 138 KQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA------SLLPPDFQSSL 191
K+Y EK + ++ R+E + R+ + ++ P + S + SS
Sbjct: 278 KKYKEKYK--VKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSS 335
Query: 192 ERPELELSRHSP--------------------RKSSSISEEKGDSDDEKPRKGERRSSRV 231
+ + RHSP R+S+S S ++ + R S +
Sbjct: 336 SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPM 395
Query: 232 RQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDE 291
R+ SQ + ++ +R R R +++ + E E E+++ D ++ +
Sbjct: 396 REKGRHDHERTSQSHDRRHERREDTRGKRDR-EKDSREEREYEQDQSSSRDHRDDREPRD 454
Query: 292 GQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQE-----------QEVLERGGRF 340
G+ R+A ++ +E + EM D T+ + +R GR
Sbjct: 455 GRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRD 514
Query: 341 TRSQEEA--------RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRL 392
T +E+ ++HL + E++ S E EI++ + + + + P P
Sbjct: 515 THRKEDTYPEESRSYGRNHLREESSRTEIRNES-RNESRSEIRNDRMGRSRGRVPELPEK 573
Query: 393 TEDRKKASLV-----------------ALPEQTASEEETPPPLLTKEASSPPPHPQLHSE 435
+ S + + PE+ E +++S H +
Sbjct: 574 GSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRD-QARDSSFERRHGERDRR 632
Query: 436 EEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKV 495
+ E + P+ P+ Q + D R + V V D + E E+
Sbjct: 633 DNRERDQRPSSPIRHQGRNDELERDERR---EERRVDRV---------DDRRDERARERD 680
Query: 496 PEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQK 555
E D +++ E E DR + K EL + E ++ +++
Sbjct: 681 RERE----------RDRERERERERERDRERE----KERELERERAREREREREKERDRE 726
Query: 556 EGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVA 615
R H D R R R R R R ++R+
Sbjct: 727 RDRDRDH------------DRERERERERDREKERERERE-----ERERERERERERERE 769
Query: 616 QARTHANPRGRPKMGSRSTS-ESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDP 674
+ R R R K R E + + R R R+ +P D S ++
Sbjct: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829
Query: 675 SSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKH--VTQRLQPERGSPKK 732
S P P+ PK R S S S + EKH ++Q ++P+
Sbjct: 830 GS-------PSPRQ---SPKRRREHSPDSDAYN--SGDDKNEKHRLLSQVVRPQ------ 871
Query: 733 CEAEEAEPPAATQPQ----TSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEP 788
E+ P T+ + E + ES R + E KE+V+ + R + ++ E
Sbjct: 872 -ESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS-SVDKQREQTEILES 929
Query: 789 PMPIADQV-----SNDDRPEGSVEDEEKKESSLPKS-FKRKISVVSATKGVPAGNSDT-- 840
A + S D DE KK++ + K K+K G+ GN +T
Sbjct: 930 SRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK---KEDDVGIERGNIETTS 986
Query: 841 EGGQPGRKRRWGASTATTQKKPSIS----------ITTESLKSLIPDIKPLAGQEAVVDL 890
E GQ ++ G + +KK S +S K P P+ +E +V++
Sbjct: 987 EDGQVFSPKK-GQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEM 1045
Query: 891 HADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPV 950
+ I ED +++ D D + T+V AE PP
Sbjct: 1046 CNGKNGILED-SQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPP- 1103
Query: 951 PPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSIT------------------ 992
PP V+ A PA TL T + S S ++I+
Sbjct: 1104 PPPVATATATTVPA-------TLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDS 1156
Query: 993 -----------IDDP---VRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTL 1038
++ P + AQ P K S+ + + R T G+L+ +
Sbjct: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDS--- 1213
Query: 1039 VEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGL 1098
+ + ++ + LH + K L + +D L
Sbjct: 1214 ----------------AHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQ---L 1254
Query: 1099 LVDRPSETKTEEQGIPRPLHPPPPPPVQPPQ-HPRAEQREQERAVREQWAEREREMERRE 1157
PS + + ++ R P Q H R+ + ++E+ +R RE
Sbjct: 1255 KRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQER--DRYEHDRERE 1312
Query: 1158 RTR---SEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDL 1214
R R +REWDRD ++ PR+R R R R R ER + ++K+ DL
Sbjct: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRER-ERERERDKRR----------------DL 1355
Query: 1215 FRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQ 1274
R+ + +++ ER +R ++R++ + + E K E + E E R
Sbjct: 1356 DRERE-------------RLISDSVER-DRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401
Query: 1275 LEREKRREHSRERDR 1289
LE R + +++R
Sbjct: 1402 LESTSRDSLALDKER 1416
Score = 75.5 bits (184), Expect = 3e-13
Identities = 158/798 (19%), Positives = 276/798 (34%), Gaps = 141/798 (17%)
Query: 186 DFQSSLERPELELSRHSPRKSSSISEE---KGDSDDEKPRKGERRSSRVRQARAAKLSEG 242
+++ S ERP +L K + E + + P + E R R+ K+++
Sbjct: 73 NYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKE 132
Query: 243 SQPAEEEEDQE-TPSRNLRVRADRNLKTEEEEEEEEEEEEDDEE-EEGDDEGQKSREAPI 300
P EEE+ E +R+ D N E E + ++ E + + E + RE I
Sbjct: 133 RTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEII 192
Query: 301 LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE 360
+K KE E+ R K R ++S +++ + KS A ++ K
Sbjct: 193 IK--KEVSPEVVRSKLSPSPSLRKSSKSPKRK-------------SSPKSSSASKKDRKT 237
Query: 361 MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT 420
+SPL +++R K++Q K+ ++PSPP P +
Sbjct: 238 SAVSSPLLDQQRNSKTNQSKKKGPRTPSPP--------------------------PPIP 271
Query: 421 KEASSPPPHPQLHSEE---EIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGL 477
++ + + + + + E + +G + D QH
Sbjct: 272 EDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHH------- 324
Query: 478 SPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELA 537
SP+SS + + + S P +++ Y Q+ L P RSA P P
Sbjct: 325 SPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSY--QRTLTPPLRRSASPYP------- 375
Query: 538 LAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPD 597
L P +Q R S + S R + R R D
Sbjct: 376 ------SHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKD 429
Query: 598 SSGSRSHSPLRSKQRDVAQARTHANPR-GRPKMGSRSTSESRSRSRSRS-------RSAS 649
S R + +S RD R PR GR + +R T + R SR R S
Sbjct: 430 SREEREYEQDQSSSRD---HRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYS 486
Query: 650 SNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRL 709
++++S P SR + ++ P+ + SS + R
Sbjct: 487 RDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNE 546
Query: 710 SQPESAEKHVTQRL---------QPERGSPKKCEAE-EAEPPAATQPQTSETQTSHLPES 759
S+ ES + R+ PE+GS ++ ++ + + ET++S+ PE
Sbjct: 547 SRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSY-PER 605
Query: 760 ER---------IHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEE 810
+R + E+ D +NR + P PI Q ND+ +E +E
Sbjct: 606 DRYPERDNRDQARDSSFERRHGERDRRDNRERDQ--RPSSPIRHQGRNDE-----LERDE 658
Query: 811 KKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTES 870
++E +R++ V + A D E + + R +++ + E
Sbjct: 659 RRE-------ERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERER 711
Query: 871 LKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGD-DGTHDKGLKICRTVTQVVPAEG 929
+ + R E E +R D D HD+ R + E
Sbjct: 712 AR--------------------EREREREKERDRERDRDRDHDRE----RERERERDREK 747
Query: 930 QENGQREEEEEEKEPEAE 947
+ +REE E E+E E E
Sbjct: 748 EREREREERERERERERE 765
Score = 69.3 bits (168), Expect = 2e-11
Identities = 70/270 (25%), Positives = 108/270 (40%), Gaps = 38/270 (14%)
Query: 1099 LVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRER 1158
L+D+ +KT + P P PPPP+ P ++ +++ V+++ E+ R+ + R R
Sbjct: 244 LLDQQRNSKTNQSKKKGPRTPSPPPPI-PEDIALGKKYKEKYKVKDRIEEKTRDGKDRGR 302
Query: 1159 TRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKT 1218
+ RDK PRS S + ++ S+ Q P+ RK
Sbjct: 303 DFERQREKRDK----PRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR-----RKR 353
Query: 1219 KAAPCIYWLPLTD--------------SQIVQKEAERAERAKEREKRRKEQEEEEQKERE 1264
+P Y LT S +K++ R+ REK R + E Q
Sbjct: 354 TPSPS-YQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDR 412
Query: 1265 KEAERERNR---QLEREKRREHSRERDRERERERERDRGDRD-RDRE-----RDRERGRE 1315
+ RE R E++ R E E+D+ R+ DR RD RDR RDR R+
Sbjct: 413 RHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRD 472
Query: 1316 ----RDRRDTKRHSRSRSRSTPVRDRGGRR 1341
RD R+ + +SR S RD R
Sbjct: 473 SRDMRDSREMRDYSRDTKESRDPRDSRSTR 502
Score = 66.2 bits (160), Expect = 2e-10
Identities = 58/230 (25%), Positives = 99/230 (43%), Gaps = 22/230 (9%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRS---RSRSRDRRR 1185
+ R ++RE+ER RE+ ERERE ER ER +RDK RE R + + RD RR
Sbjct: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
Query: 1186 KERAKSKE---------KKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTD----- 1231
++R + +E ++ KK E P+ R+ + + D
Sbjct: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKH 861
Query: 1232 ---SQIVQKEAERAERAKE-REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRER 1287
SQ+V+ + R+ E R+ +EE++K KE+ R Q +EK ++R
Sbjct: 862 RLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQR 921
Query: 1288 DRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
++ E R R +D E DR + +++ + P++ +
Sbjct: 922 EQTEILESSRMRA-QDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK 970
Score = 63.2 bits (152), Expect = 2e-09
Identities = 119/584 (20%), Positives = 218/584 (37%), Gaps = 66/584 (11%)
Query: 207 SSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRN 266
S ++E++ E+ RK ER+ S R+ +L E +++ +Q + R+RA
Sbjct: 879 SHLTEDRQGRWKEEDRKPERKESS-RRYEEQELKEKVSSVDKQREQTEILESSRMRAQDI 937
Query: 267 LKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDE---- 322
+ + E+ E + DE ++ K ++ PI K+ KE+ I R E ++
Sbjct: 938 IGHHQSEDRETSDRAHDENKKK----AKIQKKPIKKK-KEDDVGIERGNIETTSEDGQVF 992
Query: 323 RPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQG--- 379
PK + Q+++ +E+ + ++ + A+Q ++K T P+ +E ++ G
Sbjct: 993 SPK-KGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNG 1051
Query: 380 -LKEKSKS-------------PSPPRLTEDRKKASLV---ALPEQTASEEETPPPLLTKE 422
L++ K P +TE A+ + P +S PPP+ T
Sbjct: 1052 ILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATAT 1111
Query: 423 ASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSS 482
A++ P + A + +P NT +T S + + +
Sbjct: 1112 ATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTR-VEKVET 1170
Query: 483 PSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGI 542
P T ++ K P+ QK + + S + + S R P +
Sbjct: 1171 PHVTIEDAQHRK-------PMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSG 1223
Query: 543 TEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRS--RSPDSSG 600
+ L S ++++ + T R+ Q SRS+SS SRS S RS S
Sbjct: 1224 RKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESD 1283
Query: 601 SRSHSPLRS-KQRDVAQART---HANPRGRPKMGSRSTS----------ESRSRS--RSR 644
+ HS S RD Q R H R R + +R +R R R R
Sbjct: 1284 RQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRER 1343
Query: 645 SRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPK---------E 695
R + R+ L R S S +D + + + ++ CE K E
Sbjct: 1344 ERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLE 1403
Query: 696 RTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAE 739
TS S ++ R+ + + + + + ER + +E++
Sbjct: 1404 STSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESK 1447
Score = 56.6 bits (135), Expect = 2e-07
Identities = 54/233 (23%), Positives = 98/233 (42%), Gaps = 35/233 (15%)
Query: 1114 PRPLHP--PPPPPVQPPQHPRAEQREQERAVREQWAE-REREMERRERTRSEREWDRD-- 1168
P P H P PP+H R+ RE+ R E+ ++ +R ERRE TR +R+ ++D
Sbjct: 373 PYPSHSLSSPQRKQSPPRH-RSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSR 431
Query: 1169 KVREGPRSRSRSRDRRR-KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWL 1227
+ RE + +S SRD R +E ++++ + + + E
Sbjct: 432 EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRE---------------------- 469
Query: 1228 PLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRER 1287
L DS+ ++ E + +++ ++ R ++ ++ +RE + ++ + E
Sbjct: 470 -LRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGR---DTHRKEDTYPEE 525
Query: 1288 DRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340
R R R+ R R R R R D R RSR R + ++G R
Sbjct: 526 SRSYGRNHLREESSRTEIRNESRNESRSEIRND--RMGRSRGRVPELPEKGSR 576
Score = 55.8 bits (133), Expect = 3e-07
Identities = 65/216 (30%), Positives = 91/216 (42%), Gaps = 33/216 (15%)
Query: 1140 RAVREQWAERERE---MERRERTRSE--REWDRDKVREGP-------RSRSRSRDRRRKE 1187
R+ R+ R+RE R+E T E R + R+ +RE SR+ SR R +
Sbjct: 499 RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRND 558
Query: 1188 R-AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAK 1246
R +S+ + E EK +D + DS + +R
Sbjct: 559 RMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSN---------YHDSWETRSSYPERDRYP 609
Query: 1247 EREKRRKEQEEEEQKEREKEAERERNRQLEREKR-----REHSRERDRERERERERDRGD 1301
ER+ R +Q + ER + ER+R ER++R R R + ER+ RE R D
Sbjct: 610 ERDNR--DQARDSSFER-RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVD 666
Query: 1302 RDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
R DR RD ER RERDR + R R R RDR
Sbjct: 667 RVDDR-RD-ERARERDRERERDRERERERERE-RDR 699
Score = 44.3 bits (103), Expect = 8e-04
Identities = 57/227 (25%), Positives = 93/227 (40%), Gaps = 35/227 (15%)
Query: 1134 EQREQERAVREQWAEREREMERRE---RTRSEREWDRDKVREGPRSRSRSRDRRRKERAK 1190
E R+ R +E R+ R R R R+ R + SRS R+ R+E ++
Sbjct: 481 EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR 540
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK 1250
++ + + E E + +D +++ + LP ++ R R + +
Sbjct: 541 TEIRNESRNESRSE-----IRNDRMGRSRGR--VPELP--------EKGSRGSRGSQIDS 585
Query: 1251 RRKEQEEEEQKEREKEAERERNRQLEREKR---REHSRER---DRERERERERDRGD--- 1301
+ E + + ER+R ER+ R R+ S ER +R+R RERD+
Sbjct: 586 HSSNSNYHDSWET-RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSP 644
Query: 1302 -----RDRDRERDRERGRER-DRRDTKRHSRSRSRSTP-VRDRGGRR 1341
R+ + ERD R R DR D +R R+R R RDR R
Sbjct: 645 IRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERER 691
Score = 32.0 bits (71), Expect = 4.1
Identities = 47/211 (22%), Positives = 74/211 (35%), Gaps = 46/211 (21%)
Query: 166 SAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGE 225
S+ D +H S D +R E + R R+ + E D+D + PR +
Sbjct: 1278 SSPESDRQVHSRS-GSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRD 1336
Query: 226 RRSSRVR---------------------------------------QARAAKLSEGSQPA 246
R R R Q + K E
Sbjct: 1337 RDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEG 1396
Query: 247 EEEEDQETPSRNL----RVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILK 302
E E D E+ SR+ + R D++L + + EE + E + E GDDE K +A L
Sbjct: 1397 EHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDE-SKLDDAHSLG 1455
Query: 303 EFKEEG-EEIPRVKPEEMMDERPKTRSQEQE 332
EG E I + +E++ + R +Q+
Sbjct: 1456 SGAGEGYEPISDDELDEILAGDAEKREDQQD 1486
Score = 31.6 bits (70), Expect = 5.4
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 47/197 (23%)
Query: 201 HSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLR 260
HS R+SS S+ RQ + S S+ +E D R
Sbjct: 1273 HSSRRSSPESD--------------------RQVHSRSGSFDSRDRLQERD--------R 1304
Query: 261 VRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMM 320
DR E E E + + + + + D + ++R+ L+E + E E R K ++
Sbjct: 1305 YEHDR-----ERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERE---RDKRRDLD 1356
Query: 321 DERPKTRSQEQE---VLERGGRFTRSQEEARKSHLAR--QQQEKEMKTTS------PLEE 369
ER + S E +R F SQ E+ K A+ + E+++++TS E
Sbjct: 1357 RERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER 1416
Query: 370 EEREIKSSQGLKEKSKS 386
++++ S QG +E +KS
Sbjct: 1417 MDKDLGSVQGFEETNKS 1433
Score = 31.6 bits (70), Expect = 5.4
Identities = 41/162 (25%), Positives = 65/162 (40%), Gaps = 39/162 (24%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVR-----------------EGP 1174
R +RE+ER R++ + +RE ER ER+ DRD+ R EG
Sbjct: 1339 RLRERERERE-RDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGE 1397
Query: 1175 RSR---SRSRDRRRKERAK-----------SKEKKSEKKEKAQEEPPAKLLDDLFRKTKA 1220
R S SRD ++ + + KSE+ E + LDD
Sbjct: 1398 HERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSG 1457
Query: 1221 APCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKE 1262
A Y P++D ++ + A + EKR +Q+EE+ +
Sbjct: 1458 AGEGY-EPISDDELDE------ILAGDAEKREDQQDEEKMPD 1492
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 112 bits (281), Expect = 2e-24
Identities = 270/1296 (20%), Positives = 448/1296 (34%), Gaps = 213/1296 (16%)
Query: 199 SRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETP--- 255
+R S R S +G S P + R SR R+ + + TP
Sbjct: 641 ARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRG 700
Query: 256 ---SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEI- 311
SR+L R + +T + E + +S +P +K+ +
Sbjct: 701 RSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSR 760
Query: 312 ----PRVKPEEMMDER---------PKTRSQEQEVLERGGRF---TRSQEEARKSHLARQ 355
PR K + + R PK +SQ R G +S+ R+S +
Sbjct: 761 SLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSS 820
Query: 356 QQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPR---LTEDRKKASLVALPEQTASEE 412
K+ T R+ SS K KS +PPR +T + V P++ + E
Sbjct: 821 PPPKQKSKTP-----SRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVT-PQRRSCFE 874
Query: 413 ETPPPLLTKE-------ASSPPPHPQLHSEEEIEPMEG--PAPPVLIQLSP-----PNTD 458
+P P L + S PP + + P P P V +SP +
Sbjct: 875 SSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSS 934
Query: 459 ADTRELLVSQHTVQLVGGLSPLSSP--------SDTKAESPAEKVPEESVLPLVQKSTLA 510
+ + + S+ T + +SP S+ S + + SP KV E+ +++
Sbjct: 935 SPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSIS 994
Query: 511 DY---SAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPS 567
Y AQ P S P P + + +L + SL G ++S P
Sbjct: 995 PYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPG------SLSLCAGVKSS---TPP 1045
Query: 568 HRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRP 627
S + S +S RS + SP+ S S SP Q+++ +P+G
Sbjct: 1046 GESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPS-------LQSKSQTSPKGGR 1098
Query: 628 KMGSRSTSESRSRSRSRSR----SASSNSRKSLSPGVSR--DSSTSY-----------TE 670
S +E SRS R SAS + +SP SR S+SY +
Sbjct: 1099 SRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSR 1158
Query: 671 TKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPER--- 727
+ S +++A PP P+++ S VQ R PES+ P R
Sbjct: 1159 LETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDR----PESSLVFKDTLRTPPRERS 1214
Query: 728 ---GSPKKCEAEEAEPPAATQPQTSE-TQTSHLPESERIHHTVEEKEEVTMDTSENRPEN 783
SP+ E A P ++ + E + S P + + H E +E++ E+ PE
Sbjct: 1215 GAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPE- 1273
Query: 784 DVPEPPMPIADQVSNDDRPEGSVE-DEEKKESSLPKSFKRKISVVSATKGVPAGNSDTE- 841
++RP S+ D+ + ++SL ++ ++++ G P + + +
Sbjct: 1274 --------------VEERPAVSLTLDQSQSQASLEAV---EVPSMASSWGGPHFSPEHKE 1316
Query: 842 -GGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIK-----PLAGQ---EAVVDLHA 892
P R+ +G+ P + TE ++K P Q + +D+
Sbjct: 1317 LSNSPLRENSFGSPLEFRNSGP---LGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKE 1373
Query: 893 DDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAE---PP 949
+R S + D G+ ++++ V RE PE + P
Sbjct: 1374 QSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPR 1433
Query: 950 VPPQVSVEVALP-------PPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQV 1002
P + S + P P+ H + + G R+ S+ +S + +P Q
Sbjct: 1434 TPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECD-SSPEPKALPQT 1492
Query: 1003 PSPPRGKISNIVHISN-------------------LVRPFTLGQLKELLGRTGTLVEEAF 1043
P PR + + ++N V LGQ R+G+ E
Sbjct: 1493 PR-PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQ----RSRSGSSQELDV 1547
Query: 1044 WIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGL----- 1098
+ S+ + TRT L S+P + + L R
Sbjct: 1548 KPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSP-----EVDSKSRLSPRRSRSGSSP 1602
Query: 1099 -LVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVR-EQWAEREREMERR 1156
+ D+P + G P P P P+ R+ + R E + E E
Sbjct: 1603 EVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHP 1662
Query: 1157 ERTRSEREWDRD------KVREGPRSRSR------SRDRRRKERAKSKEKKSEKKEK--- 1201
++R+ R R K R PR RS +R R R++S E + +
Sbjct: 1663 PKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPP 1722
Query: 1202 --------AQEEPPAKLLDDLFRKTKAAPCIYWL------PLTDSQIVQKEAERAERAKE 1247
+ EP K R++ ++P P + +Q+ R+ R K
Sbjct: 1723 RHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKT 1782
Query: 1248 REKRRKEQEEEEQK-EREKEAERERNRQLEREKRRE--HSRERDRERERERERDRGDRDR 1304
R RR+++ Q R ++ R R+R R + HSR R+ E R R R R
Sbjct: 1783 RTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQ-ESSRTSSRRRRGR 1841
Query: 1305 DRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340
R R R R R RSRSR++P R R
Sbjct: 1842 SRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSR 1877
Score = 85.1 bits (209), Expect = 4e-16
Identities = 179/837 (21%), Positives = 300/837 (35%), Gaps = 115/837 (13%)
Query: 232 RQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDE 291
R+AR AK P +E+ S + K +++ E E + +
Sbjct: 155 RRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSK 214
Query: 292 GQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSH 351
+K R K+ K P+ K + +R ++RS R + S + A S
Sbjct: 215 KKKHRSESESKKRKHRSPT-PKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSD 273
Query: 352 LARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSP-SPPRLTEDRKKASLVALPEQTAS 410
+R + T R + G + + +P S P T ++ +S +Q +S
Sbjct: 274 TSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSS 333
Query: 411 E-EETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQH 469
E+ K A+ P P P+ S GP PP L + L +
Sbjct: 334 PYEDKDKDKKEKSATRPSPSPERSST-------GPEPPAPTPLLAERHGGSPQPLATTPL 386
Query: 470 TVQLVGGLSPLSSPSDTKAESPAEKVPE----ESVLPLVQKSTLADYSAQKDLEPESDRS 525
+ + V S S D EK+P+ ES P Q + ++ +++ S S
Sbjct: 387 SQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASS------SPES 440
Query: 526 AQPLPLKIEELALAKGITEECLKQPSLEQKEGRRA----SHTLLPSHRLKQSADSSS--- 578
+P P A G E P+ + + RA SH+ PS R+ +S ++
Sbjct: 441 PKPAP--------APGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKR 492
Query: 579 -------------SRSSS--------------SSSSSSRSRSRSPDSSG-SRS-HSPLRS 609
SRS S S S R RSRSP G SRS ++ R
Sbjct: 493 GRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRG 552
Query: 610 KQRDVAQARTHAN---PRGR-----PKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS 661
+ R + R+H+ RGR P RS S + +R RSRSR+ + +S +P
Sbjct: 553 RSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTP-AR 611
Query: 662 RDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQ 721
R S S T + S +P + + P R+ S S ARR S + +
Sbjct: 612 RGRSRSRTPARRRS---RTRSPVRRRSRSRSPARRSGRSRSRTPARR---GRSRSRTPAR 665
Query: 722 RLQPERGSP-KKCEAEEAEPPA------ATQPQTSETQTSHLPESERIHHTVEEKEEVTM 774
R + +P ++ + PA + P+ +++ L R H ++ +
Sbjct: 666 RGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSG 725
Query: 775 DTSENRPENDVPE--------PPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISV 826
+SE + ++ + P M + S R S + K SL +S
Sbjct: 726 SSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPC 785
Query: 827 VSATKGVPAGNSDTEGGQPGRK-----RRWGASTATTQKKPSISITTESLKSLIPDIKPL 881
P S + QP K RR +S++ K+ S + + +S S P K
Sbjct: 786 PKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVK 845
Query: 882 AG----QEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREE 937
+G Q ++ A++ ++ R+ + + D LK RT P+ +G
Sbjct: 846 SGTPPRQGSITSPQANEQSVTPQ--RRSCFESSPDPELK-SRT-----PSRHSCSGSSPP 897
Query: 938 EEEEKEPEAEPP---VPPQVSVEVALPP-PAEHEVKKVTLGDTLTRRSISQQKSGVS 990
+ P + P PQ V+ + P H +T R+ ++ VS
Sbjct: 898 RVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVS 954
Score = 72.0 bits (175), Expect = 4e-12
Identities = 261/1244 (20%), Positives = 410/1244 (32%), Gaps = 202/1244 (16%)
Query: 189 SSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEE 248
SS P SR +PR+S S+S PR SS + K+ + P +
Sbjct: 933 SSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSS----SPDTKVKPETPPRQS 988
Query: 249 EEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDD------EGQKSREAPILK 302
+P ++ + + +E+ D + G KS P
Sbjct: 989 HSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGES 1048
Query: 303 EFKEEGEEIPRVKPEEMMDERPKTRSQE--QEVLERGGRFTRSQEEARKSHLARQQQEKE 360
F ++ + + + D R T S E Q E ++SQ + E
Sbjct: 1049 YFGVSSLQL-KGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTE 1107
Query: 361 MKTTSPLEEEEREIKSSQGLKE---------KSKSPSPPRL-------------TEDRKK 398
+ + SP+ ++ E +S LK +S S S P + E ++K
Sbjct: 1108 LASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEK 1167
Query: 399 ASLVALPEQTAS-----EEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLS 453
+L + TAS ++ +P P+ + SS L + G +P Q S
Sbjct: 1168 MALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNS 1227
Query: 454 PPNTDADTRELLVSQHTVQLVGG--LSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLAD 511
T + EL+ + G LS LSS + S E PE P V TL
Sbjct: 1228 ALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSL-TLDQ 1286
Query: 512 YSAQKDLE-----------------PE-SDRSAQPL---------------PLKIEELAL 538
+Q LE PE + S PL PL E
Sbjct: 1287 SQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTG 1346
Query: 539 AKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDS 598
+E L P L Q E PS +K+ + SS SSS S + ++ S
Sbjct: 1347 FSSEVKEDLNGPFLNQLETD-------PSLDMKEQSTRSSGHSSSELSPDAVEKA-GMSS 1398
Query: 599 SGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRS------RSRSRSASSNS 652
+ S S L + R ++ R+ + K G T RSRS R S + S +S
Sbjct: 1399 NQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHS 1458
Query: 653 RKSLSPGVSRDSST-SYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQ 711
SPG+ T S ++ SS + A P P+ + P + R S
Sbjct: 1459 LSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSG 1518
Query: 712 PESAEKHVTQRLQPERGSPKKCEAEEAE-PPAATQPQTSETQTSHLPESERIHHTVEEKE 770
ES+ T P + ++E + P+A+ + SE+ +S P+S+ T +
Sbjct: 1519 SESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSS--PDSKAKTRTPLRQR 1576
Query: 771 EVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSAT 830
S + PE D P + GS + + K + P++ S +
Sbjct: 1577 S----RSGSSPEVDSKSRLSPRRSR-------SGSSPEVKDKPRAAPRA-------QSGS 1618
Query: 831 KGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDL 890
P + P R+ R G+S+ P S +TES
Sbjct: 1619 DSSPEPKAPAPRALP-RRSRSGSSSKGRGPSPEGSSSTESSPE----------------- 1660
Query: 891 HADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPV 950
H SR + + + + T + R+ + R PE
Sbjct: 1661 HPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRT 1720
Query: 951 PPQV--SVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRG 1008
PP+ S V+ P PAE RS +++S S R + PSP
Sbjct: 1721 PPRHRRSPSVSSPEPAEKS------------RSSRRRRSASSPRTKTTSRRGRSPSP--- 1765
Query: 1009 KISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTA 1068
+P L + + R T + + ST +R+
Sbjct: 1766 ------------KPRGLQRSRSRSRREKTRTTRR------RDRSGSSQSTSRRRQRSRSR 1807
Query: 1069 LHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPP---- 1124
+ + + A Q+ R R ++T R P P
Sbjct: 1808 SRVTRRRRGGSGYHSRSPARQES---SRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRS 1864
Query: 1125 ---VQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSR 1181
P H R+ R + R + RR R+R+ R + R P SR RSR
Sbjct: 1865 RSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSR 1924
Query: 1182 DRR---RKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKE 1238
R + R++S+ + ++ +++ P + R P P+T ++
Sbjct: 1925 SRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRR-----RSRSRTP-----PVTR----RRS 1970
Query: 1239 AERAERAKEREKRRKEQEEEEQKEREKEA--ERERNRQLEREKRREHSRERDRERERERE 1296
R R R + ++ R + + R R+R R SR R R R
Sbjct: 1971 RSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRS 2030
Query: 1297 RDRG---DRDRDRERD----RERGRERDRRDTKRHSRSRSRSTP 1333
R R R R R R R R R R R T R RS +RS P
Sbjct: 2031 RSRTPLLPRKRSRSRSPLAIRRRSRSRTPR-TARGKRSLTRSPP 2073
Score = 72.0 bits (175), Expect = 4e-12
Identities = 148/690 (21%), Positives = 237/690 (34%), Gaps = 111/690 (16%)
Query: 152 LEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISE 211
L+ + + +S+E + + G++S S+ P L+ +P + S S
Sbjct: 1369 LDMKEQSTRSSGHSSSELSPDAVEKAGMSS------NQSISSPVLDAVPRTPSRERSSSA 1422
Query: 212 EKGDSDDEKPRKGERRSSR---------------------------VRQARAAKLSEGSQ 244
+ D PR RRS + + + SE
Sbjct: 1423 SSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDS 1482
Query: 245 PAEEEEDQETPSRNLRVRADRNLK----TEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI 300
E + +TP R + L T + E E D + GQ+SR
Sbjct: 1483 SPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGS- 1541
Query: 301 LKEFKEEGEEIPRVKPEEMM--DERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQE 358
+E + P P+E D P ++++ + L + R S E KS L+ ++
Sbjct: 1542 ----SQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR 1597
Query: 359 KEMKTTSPLEEEEREIKSSQGLKEKS---KSPSPPRLTEDRKKASLVALPEQTASEEETP 415
++ ++++ R +Q + S K+P+P L + S +S+ P
Sbjct: 1598 SG--SSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGS--------SSKGRGP 1647
Query: 416 PPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDAD-----TRELLVSQHT 470
P + S P HP P P + P + TR+ +S+ +
Sbjct: 1648 SPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRS 1707
Query: 471 VQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLP 530
S SP+ PE + + + S + RS P P
Sbjct: 1708 RSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKP 1767
Query: 531 LKIE--------ELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSS--- 579
++ E + S ++ R S + + R S S S
Sbjct: 1768 RGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPAR 1827
Query: 580 -RSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESR 638
SS +SS R RSR+P +S RS S R+ ++R+ A+P + SR+ SR
Sbjct: 1828 QESSRTSSRRRRGRSRTPPTSRKRSRS--RTSPAPWKRSRSRASPATHRRSRSRTPLISR 1885
Query: 639 SRSRS--------RSRSASSNSR---------------KSLSPGVSRDSSTSYTETKDPS 675
RSRS RSRS +S +R +S +P V+R S S T T
Sbjct: 1886 RRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRR 1945
Query: 676 SGQEVATPPV----PQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPK 731
S TPPV + + R S S +S RR S+ S VT+R R SP
Sbjct: 1946 SRSR--TPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSR--SRTSPVTRRRSRSRTSP- 2000
Query: 732 KCEAEEAEPPAATQPQTSETQTSHLPESER 761
+ T P T S P + R
Sbjct: 2001 ---VTRRRSRSRTSPVTRRRSRSRTPPAIR 2027
Score = 70.5 bits (171), Expect = 1e-11
Identities = 98/365 (26%), Positives = 136/365 (37%), Gaps = 53/365 (14%)
Query: 414 TPPPLLTKEASSPPPHPQLHSEEEIEPMEGPA------------PPVLIQ-LSP-PNTDA 459
T PPLL + S PP S E P+ PP Q SP P+ +
Sbjct: 2397 TSPPLLDRARSRTPPSAPSQSRMTSERAPSPSSRMGQAPSQSLLPPAQDQPRSPVPSAFS 2456
Query: 460 DTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESV-LPLVQKSTLADYSAQKDL 518
D L++Q T + G S S T S + SV P V S + +
Sbjct: 2457 DQSRCLIAQ-TTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGE------- 2508
Query: 519 EPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSS 578
P S + QP L QP+ E++ +S + S S+ SSS
Sbjct: 2509 PPASTGAQQPSAL--------------AALQPAKERRSSSSSSSSSSSSSSSSSSSSSSS 2554
Query: 579 SRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQAR-THANPRGRPKMGSRSTSES 637
S SSSS S S P+ + R SP + + V + R P R + S S+S S
Sbjct: 2555 SSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSS 2614
Query: 638 RSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERT 697
S S S S S+SS+S S S S SS+S + + P+ A P + P ER
Sbjct: 2615 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERR 2674
Query: 698 STS--------------SSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAA 743
S S S S RR P+ + + Q ERGS + + P
Sbjct: 2675 SRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRD-QQSSSSERGSRRGQRGDSRSPSHK 2733
Query: 744 TQPQT 748
+ +T
Sbjct: 2734 RRRET 2738
Score = 67.8 bits (164), Expect = 7e-11
Identities = 114/501 (22%), Positives = 173/501 (34%), Gaps = 61/501 (12%)
Query: 185 PDFQSSLER-PELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSR--VRQARAAKLSE 241
P+ SS E PE + R+ S S E PR+ RSS R+AR ++ S
Sbjct: 1649 PEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSR 1708
Query: 242 GSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPIL 301
+ + E + P R R ++ + E E+ ++S +P
Sbjct: 1709 SASSSPETRSRTPP----RHRRSPSVSSPEPAEKSRSSRR-----------RRSASSPRT 1753
Query: 302 KEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEM 361
K G P KP + R ++R ++ R R SQ +R+ RQ+
Sbjct: 1754 KTTSRRGRS-PSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR----RQRSRSRS 1808
Query: 362 KTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTK 421
+ T R + G +S + T R++ TPP +
Sbjct: 1809 RVT-------RRRRGGSGYHSRSPARQESSRTSSRRRRG----------RSRTPPTSRKR 1851
Query: 422 EASSPPPHPQLHSEEEIEPM-----EGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGG 476
S P P S P P + + S T +R S+ +V
Sbjct: 1852 SRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRS 1911
Query: 477 LSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEEL 536
S S S ++ S V + S + RS P +
Sbjct: 1912 RSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSR 1971
Query: 537 ALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSP 596
+ IT + + R S T + R SRS +S + RSRSR+P
Sbjct: 1972 SRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRR--------RSRSRTSPVTRRRSRSRTP 2023
Query: 597 DS--SGSRSHSPL----RSKQRDVAQARTHANPR-GRPKMGSRSTSESRSRSRSRSRSAS 649
+ SRS +PL RS+ R R + R R G RS + S R RS S S
Sbjct: 2024 PAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTRSPPAIRRRSASGS 2083
Query: 650 SNSR-KSLSPGVSRDSSTSYT 669
S+ R +S +P +R+ S S T
Sbjct: 2084 SSDRSRSATPPATRNHSGSRT 2104
Score = 63.2 bits (152), Expect = 2e-09
Identities = 58/220 (26%), Positives = 86/220 (39%), Gaps = 37/220 (16%)
Query: 1130 HPRAEQREQERAVREQWAEREREMERRERTRSERE--WDRDK-VREGPRSRS----RSRD 1182
H R+ + R+ Q R R +RR R+RS + W R + + RSRS RS
Sbjct: 505 HSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHS 564
Query: 1183 RRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERA 1242
R R +S+ + ++ +++ PA+ R++++
Sbjct: 565 RSPATRGRSRSRTPARRGRSRSRTPAR------RRSRS---------------------- 596
Query: 1243 ERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDR 1302
R R + R + R + R R+R +RR SR R R R R R
Sbjct: 597 -RTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARR 655
Query: 1303 DRDRER-DRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
R R R RGR R R +R RSRSR+ R R R
Sbjct: 656 GRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSR 695
Score = 57.8 bits (138), Expect = 7e-08
Identities = 110/533 (20%), Positives = 186/533 (34%), Gaps = 70/533 (13%)
Query: 368 EEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVA-------LPEQTASEEETPPPLLT 420
EEE R ++++ K P+P L +RK+ + + EQ E++ + T
Sbjct: 39 EEELRRLEAAL-----VKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVAT 93
Query: 421 KEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL 480
+EE P + PA QL+ N + R + V G S
Sbjct: 94 FRLMLLEKDVNPGGKEET-PGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFD 152
Query: 481 SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK 540
+A+ PA + P+ L S+ + QK + + DR + E + +
Sbjct: 153 PQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRS-----ESSSPRR 207
Query: 541 GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSS---------SSSRS 591
+ K+ + E ++ H ++S D RS S++ S+S
Sbjct: 208 ERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSAD 267
Query: 592 RSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSN 651
+ S D+S SRS S R+ + GR G SE + S R S +
Sbjct: 268 SASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETA 327
Query: 652 SRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQ 711
+++ SP E KD ++ AT P P ER+ST
Sbjct: 328 TKQPSSP----------YEDKDKDKKEKSATRPSPS------PERSSTGPEP----PAPT 367
Query: 712 PESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEE 771
P AE+H P+ + E PP+ P T + PE + E
Sbjct: 368 PLLAERHGG---SPQPLATTPLSQEPVNPPSEASP-TRDRSPPKSPEKLPQSSSSESSPP 423
Query: 772 VTMDTSENRPENDVPEPPMP---------IADQVSNDDRPEGSVEDEEKKESSLPKSFKR 822
T +R + PE P P I+ ++ +R G + ++ + + R
Sbjct: 424 SPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGR 483
Query: 823 KISVVSATKGVPAGNSDTEGGQPGRK----------RRWGASTATTQKKPSIS 865
S +A +G + T+ G + +RWG S + ++ S S
Sbjct: 484 SRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRS 536
Score = 56.6 bits (135), Expect = 2e-07
Identities = 61/241 (25%), Positives = 89/241 (36%), Gaps = 32/241 (13%)
Query: 1119 PPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSR- 1177
PP P P + +H + E + + RE + RS RDK SR
Sbjct: 422 PPSPQPTKVSRHASSSP-ESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRR 480
Query: 1178 -SRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYW---------- 1226
RSR +R +S+ + K+ ++ P +R++++A W
Sbjct: 481 MGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQ------WRRSRSAQ--RWGRSRSPQRRG 532
Query: 1227 ---LPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKE---AERERNRQLEREKR 1280
P + +R R++ + R + R + A R R+R +R
Sbjct: 533 RSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARR 592
Query: 1281 REHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340
R SR R R R R R R R R R R R R R +R SRSRS P R G
Sbjct: 593 RSRSRTPTRRRSRSRTPAR--RGRSRSRTPARRRSRTRSPVRRRSRSRS---PARRSGRS 647
Query: 1341 R 1341
R
Sbjct: 648 R 648
Score = 53.9 bits (128), Expect = 1e-06
Identities = 56/268 (20%), Positives = 109/268 (40%), Gaps = 23/268 (8%)
Query: 1089 QDELDYHRGLLVDRPSETKTEE-QGIPRPLHPPPPPPVQPPQHPRAEQR---EQERAVRE 1144
Q L RG +RP EE + + L P P + + R + E E + E
Sbjct: 20 QRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEE 79
Query: 1145 QWAEREREMERRERTRS---EREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
Q E ++ E+ R E++ + E P R + + A+ EKK+E+
Sbjct: 80 QGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETH--QLAELNEKKNERLRA 137
Query: 1202 A----------QEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
A P + + + P Y L S ++ ++ K++++
Sbjct: 138 AFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRG 197
Query: 1252 RKEQEEEEQKEREKEAERERNRQLEREKRREHS----RERDRERERERERDRGDRDRDRE 1307
R+ + ++ER+K ++++++R K+R+H + + + ++++R+R R +
Sbjct: 198 RRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKS 257
Query: 1308 RDRERGRERDRRDTKRHSRSRSRSTPVR 1335
R R D + SRSRSRS +
Sbjct: 258 RRAHRSTSADSASSSDTSRSRSRSAAAK 285
Score = 49.3 bits (116), Expect = 2e-05
Identities = 60/237 (25%), Positives = 88/237 (37%), Gaps = 39/237 (16%)
Query: 1128 PQHPR-AEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRK 1186
PQ P + R +R R + A R R R TR R R R G RSRSR+ RRR
Sbjct: 537 PQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRG-RSRSRTPARRG-RSRSRTPARRRS 594
Query: 1187 E-----RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAER 1241
R +S+ + ++ +++ PA+ R+++ + + S + R
Sbjct: 595 RSRTPTRRRSRSRTPARRGRSRSRTPAR------RRSRTRSPVRRRSRSRSPARRSGRSR 648
Query: 1242 AERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREK-RREHSRERDRERERERERDRG 1300
+ R + R + R + R R R RR SR R R R R R
Sbjct: 649 SRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLV 708
Query: 1301 DRDRDRERDRER----GRERDRRDTKRHS--------------------RSRSRSTP 1333
R R R +R G +R++ R S RSRS S+P
Sbjct: 709 RRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSP 765
Score = 37.4 bits (85), Expect = 0.098
Identities = 45/197 (22%), Positives = 68/197 (34%), Gaps = 28/197 (14%)
Query: 1159 TRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKT 1218
T ++R + + P S +D+ +KE++ ++ S ++ EPPA R
Sbjct: 316 TSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHG 375
Query: 1219 KAAPCIYWLPLTDSQI-------------VQKEAERAERAKERE-----------KRRKE 1254
+ + PL+ + K E+ ++ E R
Sbjct: 376 GSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHAS 435
Query: 1255 QEEEEQKEREKEAERERNRQLEREKRREHSR-ERDRERERERERDRGDRDRDRERDRERG 1313
E K K R H R +RD+ R G R R +RG
Sbjct: 436 SSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMG-RSRS-PATAKRG 493
Query: 1314 RERDRRDTKR-HSRSRS 1329
R R R TKR HSRSRS
Sbjct: 494 RSRSRTPTKRGHSRSRS 510
Score = 34.7 bits (78), Expect = 0.63
Identities = 25/104 (24%), Positives = 38/104 (36%), Gaps = 13/104 (12%)
Query: 1103 PSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSE 1162
PS K Q +P+P P PPP ER R + + R + S
Sbjct: 2649 PSPAKPGPQALPKPASPKKPPP-------------GERRSRSPRKPIDSLRDSRSLSYSP 2695
Query: 1163 REWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEP 1206
E R + PR + S R R + + +S ++ +E P
Sbjct: 2696 VERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETP 2739
Score = 31.6 bits (70), Expect = 5.4
Identities = 45/257 (17%), Positives = 88/257 (34%), Gaps = 10/257 (3%)
Query: 123 PNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASL 182
P+S +GE + + + ++R + ++ +S+ S G +S
Sbjct: 2502 PHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS 2561
Query: 183 LPPDFQSSLERPELELSR-HSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSE 241
+ S +PE+ L R SP + + +G + P K +RRSS + ++ S
Sbjct: 2562 -DSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSS 2620
Query: 242 GSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPIL 301
S + + S + + + + + + + G++ +P
Sbjct: 2621 SSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRK 2680
Query: 302 KEFKEEGEEIPRVKPEEMM--DERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEK 359
P E +P R Q+ ERG R + + SH R++
Sbjct: 2681 PIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRE--- 2737
Query: 360 EMKTTSPLEEEEREIKS 376
T SP R +S
Sbjct: 2738 ---TPSPRPMRHRSSRS 2751
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 112 bits (279), Expect = 3e-24
Identities = 63/221 (28%), Positives = 122/221 (55%), Gaps = 21/221 (9%)
Query: 1123 PPVQPPQHPRAEQREQERAVREQWA-EREREMERRERTRSEREWDRDKVREGPRSRSRSR 1181
P QP +RE+E R++ ERE E ++ R R +R+ +R+K R+ R + +
Sbjct: 28 PCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKK 87
Query: 1182 DRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAER 1241
R+KE + K+++ EK+ K EE + + + + + KE +
Sbjct: 88 GERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTS---------------KEGKE 132
Query: 1242 AERAKEREKRRKEQEEEEQKEREKEAERERNRQLERE---KRREHSRERDRERERERERD 1298
ER +ER++ +++ E +++EREKE ER+ ++ ER+ ++ E +E++R+ ++RER+
Sbjct: 133 RERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERN 192
Query: 1299 RGDRDRDRERD--RERGRERDRRDTKRHSRSRSRSTPVRDR 1337
R +R ++RER RER +ER +++ ++ R + R T R++
Sbjct: 193 RKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK 233
Score = 99.4 bits (246), Expect = 2e-20
Identities = 61/203 (30%), Positives = 96/203 (47%), Gaps = 45/203 (22%)
Query: 1148 EREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPP 1207
ERERE+E R+ + ERE +R K R R R R++ RK KEKK E+K++
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKE------ 93
Query: 1208 AKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEA 1267
E ER +R +E+E + E++E+ +K+ +KE
Sbjct: 94 ------------------------------ERERKKRRREKENKEGEEKEKRKKKEKKER 123
Query: 1268 ERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRER---------GRERDR 1318
R ERE++ E RE +ERER++E +R+R + RER +E++R
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183
Query: 1319 RDTKRHSRSRSRSTPVRDRGGRR 1341
++ K+ R+R R+R RR
Sbjct: 184 KERKKRERNRKERKKERERKERR 206
Score = 73.6 bits (179), Expect = 1e-12
Identities = 56/214 (26%), Positives = 92/214 (42%), Gaps = 12/214 (5%)
Query: 185 PDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQ 244
P +QS + E E+ K SE K + + + RK ER R R+ R K +G +
Sbjct: 32 PGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE-RGKKEKKGER 90
Query: 245 PAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEF 304
EE E R R + E +E EE+E+ + E++E ++ +E +E
Sbjct: 91 KKEERE-----------RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEER 139
Query: 305 KEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTT 364
K E + K EE ER + +++E + G + +E+ RK R++ KE K
Sbjct: 140 KREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKE 199
Query: 365 SPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKK 398
+E K + +E+ K R T R+K
Sbjct: 200 RERKERRERKKERKKKEERKKERQKDRQTNWREK 233
Score = 50.1 bits (118), Expect = 1e-05
Identities = 52/213 (24%), Positives = 84/213 (39%), Gaps = 19/213 (8%)
Query: 141 LEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSR 200
+E ++E ++R +E E E+ E E E G + E E + R
Sbjct: 45 IETRKEGKKERESERKKERREREKRKREREKERKRERGKKE---KKGERKKEERERKKRR 101
Query: 201 HSPRKSSSISEEKGDSDDEKPR-----KGERRSSRVRQARAAKLSEGSQPAEEEEDQETP 255
+EK ++K R +G+ R + + R + + E E+++E
Sbjct: 102 REKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERK 161
Query: 256 SRNLRVRADRNLKTEEEEEEE--EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPR 313
R R R K EE +E+E E + + E E +K RE +E K+E R
Sbjct: 162 ERKKRERKQVGEKEEERKEKERKERK----KRERNRKERKKERERKERRERKKE-----R 212
Query: 314 VKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE 346
K EE ER K R ERG R + +++
Sbjct: 213 KKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 47.8 bits (112), Expect = 7e-05
Identities = 38/157 (24%), Positives = 70/157 (44%), Gaps = 3/157 (1%)
Query: 243 SQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE-EEEEEDDEEEEGDDEGQKSREAPIL 301
+QP + E +E R + R + + E E ++E E E+ E E + + ++ ++
Sbjct: 30 TQPGWQSEIRER-EREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKG 88
Query: 302 KEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEM 361
+ KEE E R + +E + K + +++E ERG +E RK R+++ KE
Sbjct: 89 ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREER-KER 147
Query: 362 KTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKK 398
+ E+ERE K + + K E +K
Sbjct: 148 ERKKEEREKERERKERKKRERKQVGEKEEERKEKERK 184
Score = 42.7 bits (99), Expect = 0.002
Identities = 42/167 (25%), Positives = 70/167 (41%), Gaps = 19/167 (11%)
Query: 276 EEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLE 335
+ E E + E E EG+K RE+ KE +E E+ ER K R +E+ E
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERRER---------EKRKREREKERKRERGKKE 85
Query: 336 RGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTED 395
+ G + + E +K +++EKE K E EE+E + + KE+ ++ + E
Sbjct: 86 KKGERKKEERERKK-----RRREKENK-----EGEEKEKRKKKEKKERGRTSKEGKERER 135
Query: 396 RKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPME 442
+++ E+ +EE KE EEE + E
Sbjct: 136 KEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKE 182
Score = 41.2 bits (95), Expect = 0.007
Identities = 33/148 (22%), Positives = 67/148 (45%), Gaps = 2/148 (1%)
Query: 268 KTEEEEEEEEEEEEDDEEEEGDDEGQKS-REAPILKEFKEEGEEIPRVKPEEMMDERPKT 326
++E E E E E + ++E + E +K RE K +E+ + R K E+ + + +
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 327 RSQEQEVLERGGRFTRSQEEARKSH-LARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSK 385
R +++ E+ + +E+ +K R + KE K EE +RE + + K++ +
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 386 SPSPPRLTEDRKKASLVALPEQTASEEE 413
R +++ V E+ E+E
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKE 182
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 111 bits (278), Expect = 4e-24
Identities = 72/207 (34%), Positives = 111/207 (53%), Gaps = 41/207 (19%)
Query: 1134 EQREQERAVREQWAEREREMERRERTRS-EREWDRDKVREGPRSRSRSRDR-RRKERAKS 1191
E++E E+ RE+ ERERE ERRER R ERE +R+K +E R R R RDR R KER +
Sbjct: 301 ERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRD 360
Query: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
++++ ++ ++ ER+ + R
Sbjct: 361 RDRERDR-------------------------------------DRDRERSSDRNKDRSR 383
Query: 1252 RKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRE 1311
+E+ + ++ERE+E ERER R+ ERE+ RE RER+RERERE+++ R DR+ D E E
Sbjct: 384 SREKSRDREREREREREREREREREREREREREREREREREREKDKKR-DREEDEEDAYE 442
Query: 1312 RGR-ERDRRDTKRHSRSRSRSTPVRDR 1337
R + ER R+ + + R ++ +R+R
Sbjct: 443 RRKLERKLREKEAAYQERLKNWEIRER 469
Score = 103 bits (256), Expect = 1e-21
Identities = 87/251 (34%), Positives = 123/251 (49%), Gaps = 69/251 (27%)
Query: 1125 VQPPQHPRAEQREQERAVREQWAEREREMER-----RERTRSEREWDRDKVREGPRSRSR 1179
++ + R +RE+ER RE+ ERERE ER RER R ER+ DRD+ +E R R R
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERER-ERDRDRDRTKERDRDRDR 363
Query: 1180 SRDR---------RRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLT 1230
RDR R K+R++S+EK +++ + + E + + R+ +
Sbjct: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERER---------- 413
Query: 1231 DSQIVQKEAERAERAKEREKRRKEQEEE-----------EQKEREKEA---ERERNRQL- 1275
++E ER ER +EREK +K EE E+K REKEA ER +N ++
Sbjct: 414 -----ERERER-EREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
Query: 1276 EREKRREHSRERDRERERERERDRG-----------DRDRD------------RERDRER 1312
ER+K RE+ +E +RE ER RE + D DRD R RDRE+
Sbjct: 468 ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREK 527
Query: 1313 GRERDRRDTKR 1323
E D RD KR
Sbjct: 528 EMEADERDRKR 538
Score = 97.8 bits (242), Expect = 6e-20
Identities = 73/219 (33%), Positives = 115/219 (52%), Gaps = 28/219 (12%)
Query: 1140 RAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRS---------RDRRRKERAK 1190
+A ++W +++ R + D + + E + R + R+ + A
Sbjct: 166 KAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAP 225
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAER------ 1244
S+E S ++K +E+ +D+FR+ AP I + +T I E E +R
Sbjct: 226 SQESDSHPRKKKKEKK-----EDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISRE 280
Query: 1245 -AKEREKRRKEQEEEEQKEREK-EAERERNRQLEREKRREHSRERDRERERERERDRGDR 1302
+K R+ +K +EE+ +KE+E+ E E+ER ERE+ RE RER RERERERER+R +R
Sbjct: 281 ISKFRDTHKKLEEEKGKKEKERQEIEKERR---ERERERERERER-RERERERERER-ER 335
Query: 1303 DRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
++++ER+RER R+RDR TK R R R RDR R
Sbjct: 336 EKEKERERERERDRDRDRTKERDRDRDRERD-RDRDRER 373
Score = 95.1 bits (235), Expect = 4e-19
Identities = 68/238 (28%), Positives = 120/238 (50%), Gaps = 37/238 (15%)
Query: 1123 PPVQPPQHPRAEQREQERAVREQWAERERE----MERRERTRSEREWDRDKVREGPRSRS 1178
P + HPR +++E++ + ++ + + + E E D+ + S+
Sbjct: 225 PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKF 284
Query: 1179 RSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKE 1238
R ++ +E KEK+ ++ EK + E + + R+ + ++E
Sbjct: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRER----------------ERE 328
Query: 1239 AERAERAKEREKRR-KEQEEEEQKEREKEAERERNRQLERE--------------KRREH 1283
ER ER +E+EK R +E+E + ++R KE +R+R+R+ +R+ + RE
Sbjct: 329 RER-EREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
Query: 1284 SRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
SR+R+RERERERER+R +R+R+RER+RER RER+R + + R R D RR
Sbjct: 388 SRDRERERERERERER-EREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
Score = 70.1 bits (170), Expect = 1e-11
Identities = 58/221 (26%), Positives = 99/221 (44%), Gaps = 47/221 (21%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKER--- 1188
R +RE+ER RE+ ERERE ER ERE ++DK R+ + +RR+ ER
Sbjct: 393 RERERERERE-REREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLR 451
Query: 1189 --------------------AKSKEKKSEKKEKAQEE--PPAKLLDDL---FRKTKAAPC 1223
+ EK++E++E+ + E AK L + + + P
Sbjct: 452 EKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPK 511
Query: 1224 IYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKER----------------EKEA 1267
Y ++ +E E A ER+++R+++E EE ++R E+EA
Sbjct: 512 YYRGSALQKRLRDREKEM--EADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEA 569
Query: 1268 ERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRER 1308
ER R Q+++E E E +E+E +RE + + ++
Sbjct: 570 ERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 69.3 bits (168), Expect = 2e-11
Identities = 90/399 (22%), Positives = 143/399 (35%), Gaps = 49/399 (12%)
Query: 124 NSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLL 183
+ ++ EE + +Q +EK+ R+ ERE E E E E E
Sbjct: 288 HKKLEEEKGKKEKERQEIEKE----RRERERERERERERRERERERERE----------- 332
Query: 184 PPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGS 243
+ + E E R R E D D E+ R +R S R ++ E S
Sbjct: 333 ----REREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
Query: 244 QPAEEEEDQETPSRNLRVR-ADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILK 302
+ E E ++E R R +R + E E E E E E+D + + +DE + +
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448
Query: 303 EFKE-EGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARK-----SHLARQQ 356
+ +E E R+K E+ ER KTR E+E R +EA++ +
Sbjct: 449 KLREKEAAYQERLKNWEIR-ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDR 507
Query: 357 QEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALP---------EQ 407
+ + S L++ R+ + E+ + L E R++ P EQ
Sbjct: 508 DDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQ 567
Query: 408 TASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVS 467
A P E+ Q E+ EPME P P T + S
Sbjct: 568 EAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKP-----TLRPISS 622
Query: 468 QHTVQLVGGLSPLSSPSDTK--------AESPAEKVPEE 498
+V G + ++P D SP ++ PEE
Sbjct: 623 APSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEE 661
Score = 60.1 bits (144), Expect = 1e-08
Identities = 108/502 (21%), Positives = 188/502 (37%), Gaps = 67/502 (13%)
Query: 151 RLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSIS 210
R E + E + + D+MI +G +L ++ S L P E H PRK
Sbjct: 184 RPETVTNDDEEALDEETKRRDQMI--KGAIEVLIREYSSELNAPSQESDSH-PRK----- 235
Query: 211 EEKGDSDDEKPRKGERRSSRVRQARAAKL-------SEGSQPAEEEEDQ-ETPSRNLRVR 262
+K E++ R+ A L E E EED+ + SR +
Sbjct: 236 -----------KKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKF 284
Query: 263 ADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDE 322
D + K EEE+ ++E+E ++ E+E + E ++ RE + +E E R K +E E
Sbjct: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERE 344
Query: 323 RPKTRSQE-------------------QEVLERGGRFTRSQEEARKSHLARQ---QQEKE 360
R + R ++ + +R +RS+E++R R+ ++E+E
Sbjct: 345 RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERE 404
Query: 361 MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTED---RKKASLVALPEQTASEEETPPP 417
+ E E + + +EK K ED R+K ++ A +E
Sbjct: 405 REREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNW 464
Query: 418 LLTKEASSPPPHPQLHSEEE-IEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGG 476
+ + + + EEE M A + L + D D + + +
Sbjct: 465 EIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRD 524
Query: 477 LSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQP---LPLKI 533
+ + E++ E L + D Q+ +E E++R QP +
Sbjct: 525 REKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQR-MEQEAERRRQPQIKQEPES 583
Query: 534 EELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRS 593
EE K EE ++P +E++E L P+ R SA S SS S +++ ++ S
Sbjct: 584 EEEEEEKQEKEEKREEP-MEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDES 642
Query: 594 ---------RSPDSSGSRSHSP 606
SPD H P
Sbjct: 643 PCGIIIPHENSPDQQQPEEHRP 664
Score = 47.4 bits (111), Expect = 9e-05
Identities = 102/508 (20%), Positives = 187/508 (36%), Gaps = 51/508 (10%)
Query: 360 EMKTTSPLEEEEREIKSSQG--LKEKSKSPSPPRLTEDRK------KASLVALPEQTASE 411
+ KT + L+E + + K+S G E + L E+ K K ++ L + +SE
Sbjct: 162 DAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSE 221
Query: 412 EETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTV 471
P ++E+ S HP+ +E+ E + P + P T D + + +
Sbjct: 222 LNAP----SQESDS---HPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKR 274
Query: 472 QLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPL 531
L+ +S DT + EK +E ++K +++ E E +R +
Sbjct: 275 DLIS--REISKFRDTHKKLEEEKGKKEKERQEIEKER-----RERERERERERERRE--- 324
Query: 532 KIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRS 591
+ E + +E ++ E+ R + ++ D RSS + SRS
Sbjct: 325 REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384
Query: 592 RSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSN 651
R +S D R R ++R+ + R R R + R + R R +
Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEE---DAY 441
Query: 652 SRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQ 711
R+ L + R+ +Y E +E + + +ER + +A+RL
Sbjct: 442 ERRKLERKL-REKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK--EAKRLK- 497
Query: 712 PESAEKHVTQRLQPE--RGS--PKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVE 767
E E + R P+ RGS K+ E E A + + E + E E I +
Sbjct: 498 -EFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE-----ELEEIRQRLL 551
Query: 768 EKEEVTMDTSENRPENDVPEPPMP-IADQVSNDDRPEGSVEDEEKKESSLPKS------- 819
+ D R E + P I + +++ E E EEK+E + +
Sbjct: 552 AEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKP 611
Query: 820 -FKRKISVVSATKGVPAGNSDTEGGQPG 846
K + +S+ V + + + PG
Sbjct: 612 CLKPTLRPISSAPSVSSASGNATPNTPG 639
Score = 38.1 bits (87), Expect = 0.057
Identities = 73/396 (18%), Positives = 126/396 (31%), Gaps = 72/396 (18%)
Query: 559 RASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSP-DSSGSRSHSPLRSKQRDVAQA 617
R +H L + K+ + R R R + R R K+++ +
Sbjct: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERE 344
Query: 618 RTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSG 677
R R R K R R R R R RS+ N +S S SRD ++
Sbjct: 345 RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERE 404
Query: 678 QEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEE 737
+E +ER + R + E +K + + + +K E +
Sbjct: 405 RE--------------REREREREREREREREREREKDKKRDREEDEEDAYERRKLERKL 450
Query: 738 AEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVS 797
E AA Q + + ++ E +EE + ++
Sbjct: 451 REKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAK---------------- 494
Query: 798 NDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTAT 857
R + +ED + PK ++ + K + + E + RKR
Sbjct: 495 ---RLKEFLEDYDDDRDD-PKYYRGS----ALQKRLRDREKEMEADERDRKRE------- 539
Query: 858 TQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKI 917
K + +I+ E D A+ R+ E E ER
Sbjct: 540 --------------KEELEEIRQRLLAEGHPDPDAELQRM-EQEAERRRQP--------- 575
Query: 918 CRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQ 953
+ Q +E +E ++E+EE+ +EP E P Q
Sbjct: 576 --QIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ 609
Score = 33.9 bits (76), Expect = 1.1
Identities = 26/142 (18%), Positives = 60/142 (42%), Gaps = 26/142 (18%)
Query: 1088 EQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQ-----ERAV 1142
++D+ Y+RG + + + +E ++ + R ++E+ +R +
Sbjct: 506 DRDDPKYYRGSALQKRLRDREKE--------------MEADERDRKREKEELEEIRQRLL 551
Query: 1143 REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKA 1202
E + + E++R E+ R + ++++ P S +++ KE EK+ E E+
Sbjct: 552 AEGHPDPDAELQRMEQEAERRR--QPQIKQEPESEEEEEEKQEKE-----EKREEPMEEE 604
Query: 1203 QEEPPAKLLDDLFRKTKAAPCI 1224
+E L R +AP +
Sbjct: 605 EEPEQKPCLKPTLRPISSAPSV 626
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo
sapiens]
Length = 624
Score = 111 bits (278), Expect = 4e-24
Identities = 77/277 (27%), Positives = 139/277 (50%), Gaps = 25/277 (9%)
Query: 1080 KFLCADYAEQDE----LDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQ 1135
+F ++A+Q+ L ++ + DRP + I +P P PQ E
Sbjct: 223 RFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKP-------PEMTPQAAAKEL 275
Query: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEK- 1194
E + VRE + +E +ER+ R + +SRS S+ R++R++SK +
Sbjct: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335
Query: 1195 ------KSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLT-DSQIVQKEAERAERAKE 1247
+S +K++ + + P K + K+ + D++ KE ER +
Sbjct: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395
Query: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE 1307
++R +E+E E++KER K +R++ R+ +REK +E RER+RE+E E++R D+++++E
Sbjct: 396 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR---DKEKEKE 452
Query: 1308 RDRERGRERDRR---DTKRHSRSRSRSTPVRDRGGRR 1341
+D+E+ RE+DR D KR +SR+ P RR
Sbjct: 453 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
Score = 97.4 bits (241), Expect = 8e-20
Identities = 104/441 (23%), Positives = 181/441 (41%), Gaps = 83/441 (18%)
Query: 939 EEEKEPEAEPPVPPQVSVEVA---LPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDD 995
EE K P P S+ LP P + + TLG S+S + + +D
Sbjct: 103 EESKALSLLAPAPTMTSLMPGAGLLPIPTPNPL--TTLGV-----SLSSLGAIPAAALDP 155
Query: 996 PVRT-AQVPSPPR---------GKISNIVHISNL-VRPFTLGQLKELLGRTGTLVEEAFW 1044
+ T ++P PP +I V++ NL + T QL E + G +
Sbjct: 156 NIATLGEIPQPPLMGNVDPSKIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMA 215
Query: 1045 IDKIKS--HCFVTYS---TVEEAVATRTALHG-------------VKWPQSNPKFLCADY 1086
D+ + FV ++ +V A+A + G VK P+ P+ +
Sbjct: 216 GDETQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKEL 275
Query: 1087 AEQ----DELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAV 1142
E E ++ S E +G H H R ++ + +
Sbjct: 276 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 335
Query: 1143 REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKA 1202
R R R+ +RR ++ + + R RSRS SRD+R+ R K KEK+ K++
Sbjct: 336 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 395
Query: 1203 QEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKE 1262
++E +KE E+ + + + R KE+E++ +K+
Sbjct: 396 EKERER---------------------------EKEREKEKERGKNKDRDKEREKDREKD 428
Query: 1263 REKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRE----------- 1311
+EK+ ERER ++ E+++ +E +E+D+E+ERE++R + + D R++D++
Sbjct: 429 KEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK-EIDEKRKKDKKSRTPPRSYNAS 487
Query: 1312 -RGRERDRRDTKRHSRSRSRS 1331
R R R +R SRS SRS
Sbjct: 488 RRSRSSSRERRRRRSRSSSRS 508
Score = 83.6 bits (205), Expect = 1e-15
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 36/228 (15%)
Query: 1132 RAEQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR---KE 1187
R + +E+ER +++ ERERE ER + + DRDK RE R + + +DR R KE
Sbjct: 381 REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 440
Query: 1188 RAKSKEKKSEK---KEKAQEEPPAKLLDDLFRKTKAA---PCIYWLPLTDSQIVQKEAER 1241
K ++K+ EK KEK +E+ +K +D+ +K K + P Y A R
Sbjct: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY------------NASR 488
Query: 1242 AERAKEREKRRKEQEEEEQKEREKE----------AERERNRQ-LEREKRREHSRERDRE 1290
R+ RE+RR+ + R + + R RN++ +REK R+H ER RE
Sbjct: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-RE 547
Query: 1291 RERERERDRGDRDRDRERDRERGRE--RDRRDTKRHSRSRSRSTPVRD 1336
RER + DRD + E+ +++ K S S+ +D
Sbjct: 548 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 595
Score = 58.2 bits (139), Expect = 5e-08
Identities = 85/405 (20%), Positives = 153/405 (37%), Gaps = 36/405 (8%)
Query: 41 KLPKMPEAVGTDPSTSRKMAELEEVTLDGK-PLQALRVTDLKAALEQRGLAKSGQKSALV 99
++P+ P DPS K+ E+ G Q L +Q G K + +
Sbjct: 162 EIPQPPLMGNVDPS---KIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDE 218
Query: 100 KRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREA 159
+ +E ++S P A G+ + + + K E+ Q +E E
Sbjct: 219 TQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEV 278
Query: 160 AE-LEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH--SPRKSSSISEEKGDS 216
+ + EA + +++ + P+ S ER H S +SSS S +
Sbjct: 279 MKRVREAQSF----------ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 328
Query: 217 DDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE 276
K R SR RQ + + S+ + + SR+ D+ T E+ +E+
Sbjct: 329 SQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 387
Query: 277 EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKT--RSQEQEVL 334
E +E D E+E + E ++ +E KE G+ R K E E+ K R +E+E
Sbjct: 388 ERVKEKDREKEREREKEREKE-------KERGKNKDRDKEREKDREKDKEKDREREREKE 440
Query: 335 ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE 394
R ++E K + + KE+ +++ R S +S+S S E
Sbjct: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS----RE 496
Query: 395 DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIE 439
R++ S ++ T + K + SP P + +++ E
Sbjct: 497 RRRRRS-----RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 536
Score = 55.5 bits (132), Expect = 3e-07
Identities = 57/294 (19%), Positives = 117/294 (39%), Gaps = 10/294 (3%)
Query: 116 TPHAAFQPNSQIGEEMSQ-NSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMI 174
TP AA + ++ + + + SFI +E + +R +R + S+ S+
Sbjct: 267 TPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS-SKSHSR 325
Query: 175 HPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQA 234
+ S R + SP K S S E+ S + +R+ +R +
Sbjct: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 385
Query: 235 RAAKLSEGSQPAEEEEDQETPSRNLRVR-ADRNLKTEEEEE-------EEEEEEEDDEEE 286
++ E + E E ++E R + DR+ + E++ E E E E+E +++
Sbjct: 386 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 445
Query: 287 EGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE 346
+ + E ++ +E K+ +E +E + + R S+ R R RS+
Sbjct: 446 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505
Query: 347 ARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKAS 400
+R ++ + K ++ SP +++ K + S+ R T RK ++
Sbjct: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 559
Score = 55.5 bits (132), Expect = 3e-07
Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 44/327 (13%)
Query: 551 SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSK 610
S E+K GR SHT S+S SSS S SR R RS SRSH+ RS+
Sbjct: 300 SNERKGGRSRSHT--------------RSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSR 344
Query: 611 QRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS-----RDSS 665
Q+D R R K + S+SR R +SRSRS S + RK + ++
Sbjct: 345 QKD----------RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD 394
Query: 666 TSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPE---SAEKHVTQR 722
++ +E K+R + R + E EK Q
Sbjct: 395 REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD 454
Query: 723 LQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPE 782
+ ER + E +E + + S T S R + E+ +R
Sbjct: 455 KEKEREKDRSKEIDEKR----KKDKKSRTPPRSYNASRRSRSSSRERRR-----RRSRSS 505
Query: 783 NDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEG 842
+ P I + S P + ++K+E +R+ S + + ++D +G
Sbjct: 506 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS--MRKSSNDRDG 563
Query: 843 GQPGRKRRWGASTATTQKKPSISITTE 869
+ K K+P S++ E
Sbjct: 564 KEKLEKNSTSLKEKEHNKEPDSSVSKE 590
Score = 54.7 bits (130), Expect = 6e-07
Identities = 118/567 (20%), Positives = 204/567 (35%), Gaps = 81/567 (14%)
Query: 380 LKEKSKSPS----PPRLTEDRKKASLVALPEQTASEEETPPPLLTK--EASSPPPHPQLH 433
+ E+SK+ S P +T A L+ +P TP PL T SS P
Sbjct: 101 IPEESKALSLLAPAPTMTSLMPGAGLLPIP--------TPNPLTTLGVSLSSLGAIPAAA 152
Query: 434 SEEEIEPM-EGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPA 492
+ I + E P PP++ + P D R + V G L+ ++ +D E
Sbjct: 153 LDPNIATLGEIPQPPLMGNVDPSKIDEIRRTVYV--------GNLNSQTTTADQLLEF-F 203
Query: 493 EKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALA------KGITEEC 546
++V E + + T A + +D+++ P L +
Sbjct: 204 KQVGEVKFVRMAGDETQPTRFAFVEF---ADQNSVPRALAFNGVMFGDRPLKINHSNNAI 260
Query: 547 LKQPSLEQKEGRRASHTLLPSHRLKQSADSS-----SSRSSSSSSSSSRSRSRSPDSSGS 601
+K P + + + ++ R QS S+ S +S+ SRS +RS S S
Sbjct: 261 VKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSS 320
Query: 602 RSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS 661
+SHS R + + ++R+H R R K RS S + RS+SR R RKS S S
Sbjct: 321 KSHS-RRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRER------RKSRSRSHS 373
Query: 662 RDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQ 721
RD E + KER + R + EK +
Sbjct: 374 RDKRKDTREK-------------------IKEKERVKEKDREKERER---EKEREKEKER 411
Query: 722 RLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRP 781
+R ++ + E+ + + + E + E E+ +E+E+ + +
Sbjct: 412 GKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471
Query: 782 ENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESS-----LPKSFKRKISVVSATKGVPAG 836
+ D P + S R + SS K+ KRK S + +
Sbjct: 472 KKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKK 531
Query: 837 NSDTEGGQPGRKRRWGASTATTQKKPS--------ISITTESLKSLIPDIKPLAGQEAVV 888
+ E + R +T+ +K S + + SLK + +P + V
Sbjct: 532 DKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV 591
Query: 889 DLHADDSRISEDETERNGDDGTHDKGL 915
D D R E++ + NG+ +++ L
Sbjct: 592 D-DKDAPRTEENKIQHNGNCQLNEENL 617
Score = 48.9 bits (115), Expect = 3e-05
Identities = 46/234 (19%), Positives = 97/234 (41%), Gaps = 28/234 (11%)
Query: 190 SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE 249
S R + + +R ++ + E+ + + E+ ++ E+ R + K E + ++E
Sbjct: 371 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 430
Query: 250 EDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEE--EGDDEGQKSREAPILKEFKEE 307
+D+E R DR+ + E+E+++E+E E+D +E E + +KSR P
Sbjct: 431 KDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 489
Query: 308 GEEIPR-------------------VKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA- 347
R +K + P++R+++ + E+ + E
Sbjct: 490 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549
Query: 348 -----RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396
RKS R +EK K ++ L+E+E + + ++ PR E++
Sbjct: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
Score = 48.5 bits (114), Expect = 4e-05
Identities = 65/341 (19%), Positives = 123/341 (36%), Gaps = 38/341 (11%)
Query: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666
+R Q ++ A + + + G RS S +RS+SRS S+S S R S+ S
Sbjct: 282 VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-----SKHRSR 336
Query: 667 SYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPE 726
S+ ++ + + P + + ++ + S S R+ ++ + EK + E
Sbjct: 337 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE 396
Query: 727 RGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVP 786
+ ++ E E+ + + + E + + E+ EKE E E D
Sbjct: 397 KEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD-- 454
Query: 787 EPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPG 846
E E +K+ S KRK S T S
Sbjct: 455 -------------------KEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495
Query: 847 RKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDL-HADDSRISEDETERN 905
+RR + +++ + S +I +S +S P + ++ + H + R E T
Sbjct: 496 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR 555
Query: 906 GDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEA 946
D K+ + T + +E+E KEP++
Sbjct: 556 KSSNDRDGKEKLEKNSTSL-----------KEKEHNKEPDS 585
Score = 40.8 bits (94), Expect = 0.009
Identities = 79/386 (20%), Positives = 137/386 (35%), Gaps = 56/386 (14%)
Query: 314 VKPEEMMDERPKTRSQE-QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEER 372
VKP EM P+ ++E +EV++R A + + + K ++ S + R
Sbjct: 261 VKPPEMT---PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317
Query: 373 EIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQL 432
S +++S+S R + +R ++ ++ ++P +K +
Sbjct: 318 SSSKSHSRRKRSQSKHRSR-SHNRSRSR-----QKDRRRSKSPHKKRSKSRERRKSRSRS 371
Query: 433 HSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPA 492
HS ++ + DTRE + + V+ + + E
Sbjct: 372 HSRDKRK--------------------DTREKIKEKERVK------EKDREKEREREKER 405
Query: 493 EKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSL 552
EK E K D K+ + E +R + + +E + +E K S
Sbjct: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465
Query: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSS------GSRSHSP 606
E E R+ R ++ S S S SRS SRSP +S SRS SP
Sbjct: 466 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 525
Query: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSR---KSLSPGVSRD 663
++D + + + SE R R RS S SSN R + L +
Sbjct: 526 RSRNKKDKKREKERDH-----------ISERRERERSTSMRKSSNDRDGKEKLEKNSTSL 574
Query: 664 SSTSYTETKDPSSGQEVATPPVPQLQ 689
+ + D S +EV P+ +
Sbjct: 575 KEKEHNKEPDSSVSKEVDDKDAPRTE 600
Score = 37.0 bits (84), Expect = 0.13
Identities = 39/199 (19%), Positives = 78/199 (39%), Gaps = 19/199 (9%)
Query: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201
EK +E R+R ERE + ++ + +D+ E S E++ R
Sbjct: 426 EKDKEKDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRS------------KEIDEKRK 472
Query: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRV 261
+KS + S + ERR R +R++ S + + + +PS R
Sbjct: 473 KDKKSRTPPRSYNASRRSRSSSRERRRRR---SRSSSRSPRTSKTIKRKSSRSPSPRSRN 529
Query: 262 RADRNLKTEEE---EEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEE 318
+ D+ + E + E E E + D +G++ E ++E + P +
Sbjct: 530 KKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 589
Query: 319 MMDERPKTRSQEQEVLERG 337
+D++ R++E ++ G
Sbjct: 590 EVDDKDAPRTEENKIQHNG 608
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo
sapiens]
Length = 508
Score = 111 bits (278), Expect = 4e-24
Identities = 77/277 (27%), Positives = 139/277 (50%), Gaps = 25/277 (9%)
Query: 1080 KFLCADYAEQDE----LDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQ 1135
+F ++A+Q+ L ++ + DRP + I +P P PQ E
Sbjct: 107 RFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKP-------PEMTPQAAAKEL 159
Query: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEK- 1194
E + VRE + +E +ER+ R + +SRS S+ R++R++SK +
Sbjct: 160 EEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRS 219
Query: 1195 ------KSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLT-DSQIVQKEAERAERAKE 1247
+S +K++ + + P K + K+ + D++ KE ER +
Sbjct: 220 RSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDR 279
Query: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE 1307
++R +E+E E++KER K +R++ R+ +REK +E RER+RE+E E++R D+++++E
Sbjct: 280 EKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR---DKEKEKE 336
Query: 1308 RDRERGRERDRR---DTKRHSRSRSRSTPVRDRGGRR 1341
+D+E+ RE+DR D KR +SR+ P RR
Sbjct: 337 QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 373
Score = 97.1 bits (240), Expect = 1e-19
Identities = 59/214 (27%), Positives = 107/214 (50%), Gaps = 40/214 (18%)
Query: 1130 HPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERA 1189
H R ++ + + R R R+ +RR ++ + + R RSRS SRD+R+ R
Sbjct: 207 HSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTRE 266
Query: 1190 KSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKERE 1249
K KEK+ K++ ++E +KE E+ + + +
Sbjct: 267 KIKEKERVKEKDREKERER---------------------------EKEREKEKERGKNK 299
Query: 1250 KRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERD 1309
R KE+E++ +K++EK+ ERER ++ E+++ +E +E+D+E+ERE++R + + D R++D
Sbjct: 300 DRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK-EIDEKRKKD 358
Query: 1310 RE------------RGRERDRRDTKRHSRSRSRS 1331
++ R R R +R SRS SRS
Sbjct: 359 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRS 392
Score = 83.6 bits (205), Expect = 1e-15
Identities = 68/228 (29%), Positives = 107/228 (46%), Gaps = 36/228 (15%)
Query: 1132 RAEQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR---KE 1187
R + +E+ER +++ ERERE ER + + DRDK RE R + + +DR R KE
Sbjct: 265 REKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKE 324
Query: 1188 RAKSKEKKSEK---KEKAQEEPPAKLLDDLFRKTKAA---PCIYWLPLTDSQIVQKEAER 1241
K ++K+ EK KEK +E+ +K +D+ +K K + P Y A R
Sbjct: 325 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY------------NASR 372
Query: 1242 AERAKEREKRRKEQEEEEQKEREKE----------AERERNRQ-LEREKRREHSRERDRE 1290
R+ RE+RR+ + R + + R RN++ +REK R+H ER RE
Sbjct: 373 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER-RE 431
Query: 1291 RERERERDRGDRDRDRERDRERGRE--RDRRDTKRHSRSRSRSTPVRD 1336
RER + DRD + E+ +++ K S S+ +D
Sbjct: 432 RERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKD 479
Score = 58.2 bits (139), Expect = 5e-08
Identities = 85/405 (20%), Positives = 153/405 (37%), Gaps = 36/405 (8%)
Query: 41 KLPKMPEAVGTDPSTSRKMAELEEVTLDGK-PLQALRVTDLKAALEQRGLAKSGQKSALV 99
++P+ P DPS K+ E+ G Q L +Q G K + +
Sbjct: 46 EIPQPPLMGNVDPS---KIDEIRRTVYVGNLNSQTTTADQLLEFFKQVGEVKFVRMAGDE 102
Query: 100 KRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREA 159
+ +E ++S P A G+ + + + K E+ Q +E E
Sbjct: 103 TQPTRFAFVEFADQNSVPRALAFNGVMFGDRPLKINHSNNAIVKPPEMTPQAAAKELEEV 162
Query: 160 AE-LEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH--SPRKSSSISEEKGDS 216
+ + EA + +++ + P+ S ER H S +SSS S +
Sbjct: 163 MKRVREAQSF----------ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR 212
Query: 217 DDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEE 276
K R SR RQ + + S+ + + SR+ D+ T E+ +E+
Sbjct: 213 SQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 271
Query: 277 EEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKT--RSQEQEVL 334
E +E D E+E + E ++ +E KE G+ R K E E+ K R +E+E
Sbjct: 272 ERVKEKDREKEREREKEREKE-------KERGKNKDRDKEREKDREKDKEKDREREREKE 324
Query: 335 ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE 394
R ++E K + + KE+ +++ R S +S+S S E
Sbjct: 325 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS----RE 380
Query: 395 DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIE 439
R++ S ++ T + K + SP P + +++ E
Sbjct: 381 RRRRRS-----RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKRE 420
Score = 55.5 bits (132), Expect = 3e-07
Identities = 57/294 (19%), Positives = 117/294 (39%), Gaps = 10/294 (3%)
Query: 116 TPHAAFQPNSQIGEEMSQ-NSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMI 174
TP AA + ++ + + + SFI +E + +R +R + S+ S+
Sbjct: 151 TPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSS-SKSHSR 209
Query: 175 HPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQA 234
+ S R + SP K S S E+ S + +R+ +R +
Sbjct: 210 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK 269
Query: 235 RAAKLSEGSQPAEEEEDQETPSRNLRVR-ADRNLKTEEEEE-------EEEEEEEDDEEE 286
++ E + E E ++E R + DR+ + E++ E E E E+E +++
Sbjct: 270 EKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDR 329
Query: 287 EGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE 346
+ + E ++ +E K+ +E +E + + R S+ R R RS+
Sbjct: 330 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 389
Query: 347 ARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKAS 400
+R ++ + K ++ SP +++ K + S+ R T RK ++
Sbjct: 390 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 443
Score = 55.5 bits (132), Expect = 3e-07
Identities = 75/327 (22%), Positives = 118/327 (36%), Gaps = 44/327 (13%)
Query: 551 SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSK 610
S E+K GR SHT S+S SSS S SR R RS SRSH+ RS+
Sbjct: 184 SNERKGGRSRSHT--------------RSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSR 228
Query: 611 QRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS-----RDSS 665
Q+D R R K + S+SR R +SRSRS S + RK + ++
Sbjct: 229 QKD----------RRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKD 278
Query: 666 TSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPE---SAEKHVTQR 722
++ +E K+R + R + E EK Q
Sbjct: 279 REKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD 338
Query: 723 LQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPE 782
+ ER + E +E + + S T S R + E+ +R
Sbjct: 339 KEKEREKDRSKEIDEKR----KKDKKSRTPPRSYNASRRSRSSSRERRR-----RRSRSS 389
Query: 783 NDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEG 842
+ P I + S P + ++K+E +R+ S + + ++D +G
Sbjct: 390 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS--MRKSSNDRDG 447
Query: 843 GQPGRKRRWGASTATTQKKPSISITTE 869
+ K K+P S++ E
Sbjct: 448 KEKLEKNSTSLKEKEHNKEPDSSVSKE 474
Score = 54.3 bits (129), Expect = 8e-07
Identities = 75/359 (20%), Positives = 131/359 (36%), Gaps = 43/359 (11%)
Query: 570 LKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKM 629
+ + + S +S+ SRS +RS S S+SHS R + + ++R+H R R K
Sbjct: 173 ISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHS-RRKRSQSKHRSRSHNRSRSRQKD 231
Query: 630 GSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQ 689
RS S + RS+SR R RKS S SRD E
Sbjct: 232 RRRSKSPHKKRSKSRER------RKSRSRSHSRDKRKDTREK------------------ 267
Query: 690 VCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTS 749
+ KER + R + EK + +R ++ + E+ + + +
Sbjct: 268 -IKEKERVKEKDREKERER---EKEREKEKERGKNKDRDKEREKDREKDKEKDREREREK 323
Query: 750 ETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDE 809
E + E E+ +E+E+ + + + D P + S R
Sbjct: 324 EHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRR 383
Query: 810 EKKESS-----LPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPS- 863
+ SS K+ KRK S + + + E + R +T+ +K S
Sbjct: 384 RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSN 443
Query: 864 -------ISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGL 915
+ + SLK + +P + VD D R E++ + NG+ +++ L
Sbjct: 444 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD-DKDAPRTEENKIQHNGNCQLNEENL 501
Score = 48.9 bits (115), Expect = 3e-05
Identities = 46/234 (19%), Positives = 97/234 (41%), Gaps = 28/234 (11%)
Query: 190 SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE 249
S R + + +R ++ + E+ + + E+ ++ E+ R + K E + ++E
Sbjct: 255 SHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKE 314
Query: 250 EDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEE--EGDDEGQKSREAPILKEFKEE 307
+D+E R DR+ + E+E+++E+E E+D +E E + +KSR P
Sbjct: 315 KDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRR 373
Query: 308 GEEIPR-------------------VKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA- 347
R +K + P++R+++ + E+ + E
Sbjct: 374 SRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 433
Query: 348 -----RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396
RKS R +EK K ++ L+E+E + + ++ PR E++
Sbjct: 434 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 487
Score = 48.5 bits (114), Expect = 4e-05
Identities = 65/341 (19%), Positives = 123/341 (36%), Gaps = 38/341 (11%)
Query: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666
+R Q ++ A + + + G RS S +RS+SRS S+S S R S+ S
Sbjct: 166 VREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQ-----SKHRSR 220
Query: 667 SYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPE 726
S+ ++ + + P + + ++ + S S R+ ++ + EK + E
Sbjct: 221 SHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDRE 280
Query: 727 RGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVP 786
+ ++ E E+ + + + E + + E+ EKE E E D
Sbjct: 281 KEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQD-- 338
Query: 787 EPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPG 846
E E +K+ S KRK S T S
Sbjct: 339 -------------------KEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 379
Query: 847 RKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDL-HADDSRISEDETERN 905
+RR + +++ + S +I +S +S P + ++ + H + R E T
Sbjct: 380 ERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR 439
Query: 906 GDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEA 946
D K+ + T + +E+E KEP++
Sbjct: 440 KSSNDRDGKEKLEKNSTSL-----------KEKEHNKEPDS 469
Score = 40.8 bits (94), Expect = 0.009
Identities = 79/386 (20%), Positives = 137/386 (35%), Gaps = 56/386 (14%)
Query: 314 VKPEEMMDERPKTRSQE-QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEER 372
VKP EM P+ ++E +EV++R A + + + K ++ S + R
Sbjct: 145 VKPPEMT---PQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 201
Query: 373 EIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQL 432
S +++S+S R + +R ++ ++ ++P +K +
Sbjct: 202 SSSKSHSRRKRSQSKHRSR-SHNRSRSR-----QKDRRRSKSPHKKRSKSRERRKSRSRS 255
Query: 433 HSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPA 492
HS ++ + DTRE + + V+ + + E
Sbjct: 256 HSRDKRK--------------------DTREKIKEKERVK------EKDREKEREREKER 289
Query: 493 EKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSL 552
EK E K D K+ + E +R + + +E + +E K S
Sbjct: 290 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 349
Query: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSS------GSRSHSP 606
E E R+ R ++ S S S SRS SRSP +S SRS SP
Sbjct: 350 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSP 409
Query: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSR---KSLSPGVSRD 663
++D + + + SE R R RS S SSN R + L +
Sbjct: 410 RSRNKKDKKREKERDH-----------ISERRERERSTSMRKSSNDRDGKEKLEKNSTSL 458
Query: 664 SSTSYTETKDPSSGQEVATPPVPQLQ 689
+ + D S +EV P+ +
Sbjct: 459 KEKEHNKEPDSSVSKEVDDKDAPRTE 484
Score = 37.0 bits (84), Expect = 0.13
Identities = 39/199 (19%), Positives = 78/199 (39%), Gaps = 19/199 (9%)
Query: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201
EK +E R+R ERE + ++ + +D+ E S E++ R
Sbjct: 310 EKDKEKDRER-EREKEHEKDRDKEKEKEQDKEKEREKDRS------------KEIDEKRK 356
Query: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRV 261
+KS + S + ERR R +R++ S + + + +PS R
Sbjct: 357 KDKKSRTPPRSYNASRRSRSSSRERRRRR---SRSSSRSPRTSKTIKRKSSRSPSPRSRN 413
Query: 262 RADRNLKTEEE---EEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEE 318
+ D+ + E + E E E + D +G++ E ++E + P +
Sbjct: 414 KKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSK 473
Query: 319 MMDERPKTRSQEQEVLERG 337
+D++ R++E ++ G
Sbjct: 474 EVDDKDAPRTEENKIQHNG 492
Score = 31.2 bits (69), Expect = 7.0
Identities = 24/117 (20%), Positives = 48/117 (41%), Gaps = 1/117 (0%)
Query: 1085 DYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVRE 1144
D ++ E D + DR E + + + PP + +R + R+
Sbjct: 330 DKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 389
Query: 1145 QWAEREREMERRERTRSEREWDRDKV-REGPRSRSRSRDRRRKERAKSKEKKSEKKE 1200
+ R + +R+ +RS R+K ++ + R +RR +ER+ S K S ++
Sbjct: 390 SRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 446
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 110 bits (275), Expect = 9e-24
Identities = 67/208 (32%), Positives = 114/208 (54%), Gaps = 17/208 (8%)
Query: 1125 VQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRR 1184
+ P R +R++ER RE+ +RERE ER+ R R ++E + K RE + R R R R
Sbjct: 25 ISKPCTQRESERKKERREREK-RKREREKERK-RERGKKEKKKRKKRERGKERERKRKER 82
Query: 1185 RKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAER 1244
K+R + +EK+ K++K +++ K RK K +KE ER +
Sbjct: 83 EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE--------------RKERERENK 128
Query: 1245 AKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDR 1304
+ KR+K ++++ +KER++E ER + R+ +R+KR++ RE+ RER R+ + +R
Sbjct: 129 QRRERKRKKRRKKKRRKERKREKERGK-RERKRKKRKKEEREKKRERNRKERKKERERKE 187
Query: 1305 DRERDRERGRERDRRDTKRHSRSRSRST 1332
RER +ER +ER ++ ++ R R T
Sbjct: 188 RRERKKERKKERRKKKERKKDRKTDRQT 215
Score = 104 bits (260), Expect = 5e-22
Identities = 60/199 (30%), Positives = 113/199 (56%), Gaps = 37/199 (18%)
Query: 1148 EREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPP 1207
E ER+ ERRER + +RE ++++ RE R + + R+++ER K +E+K +++EK ++E
Sbjct: 33 ESERKKERREREKRKREREKERKRE--RGKKEKKKRKKRERGKERERKRKEREKQRKE-- 88
Query: 1208 AKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQ----EEEEQKER 1263
++E ER +R KE++KR ++Q E +++KER
Sbjct: 89 ----------------------------RREKERRKRKKEKKKRERKQRGRRERKKKKER 120
Query: 1264 -EKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTK 1322
E+E E ++ R+ +R+KRR+ R ++R+RE+ER + R + ++ +RE+ RER+R++ K
Sbjct: 121 KERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERK 180
Query: 1323 RHSRSRSRSTPVRDRGGRR 1341
+ + R ++R R
Sbjct: 181 KERERKERRERKKERKKER 199
Score = 66.2 bits (160), Expect = 2e-10
Identities = 36/116 (31%), Positives = 69/116 (59%), Gaps = 5/116 (4%)
Query: 1230 TDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDR 1289
T+ Q+V + +R+KE+ E E+++RE+E ER+R R ++EK++ RER +
Sbjct: 15 TELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERG-KKEKKKRKKRERGK 73
Query: 1290 ERER---ERERDRGD-RDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
ERER ERE+ R + R+++R + ++ ++R+R+ R R + + R+R ++
Sbjct: 74 ERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQ 129
Score = 56.6 bits (135), Expect = 2e-07
Identities = 40/187 (21%), Positives = 87/187 (46%), Gaps = 2/187 (1%)
Query: 210 SEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKT 269
SE K + + + RK ER R R+ R K + + E +++E R R + + +
Sbjct: 34 SERKKERREREKRKREREKERKRE-RGKKEKKKRKKRERGKERER-KRKEREKQRKERRE 91
Query: 270 EEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQ 329
+E + ++E+++ + ++ G E +K +E + ++ E R K + + + R +
Sbjct: 92 KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 330 EQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSP 389
E+ ER + + +E +K R++++KE + E ++ K + KE+ K
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKT 211
Query: 390 PRLTEDR 396
R T+ +
Sbjct: 212 DRQTDSQ 218
Score = 50.1 bits (118), Expect = 1e-05
Identities = 38/174 (21%), Positives = 79/174 (45%), Gaps = 10/174 (5%)
Query: 225 ERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDE 284
+R S R ++ R + + + E + ++ + R + +R K E + +E E++ +
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERG-KERERKRKEREKQRKER 89
Query: 285 EEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQ 344
E+ E +K ++ +E K+ G + K E ER + +E++ +R + R +
Sbjct: 90 REK---ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 345 EEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKK 398
+ K R+++ K+ K +EERE K + KE+ K E +K+
Sbjct: 147 RKREKERGKRERKRKKRK------KEEREKKRERNRKERKKERERKERRERKKE 194
Score = 48.1 bits (113), Expect = 6e-05
Identities = 45/221 (20%), Positives = 94/221 (42%), Gaps = 20/221 (9%)
Query: 113 KHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDE 172
K + AA + N+++ + +S + K +++ E ++R ERE R+ +E E +
Sbjct: 3 KAISSRAAVKLNTEL-QMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKK 61
Query: 173 MIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRS-SRV 231
+ ++ E R RK ++ + + RK E++ R
Sbjct: 62 E--------------KKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERK 107
Query: 232 RQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDE 291
++ R + + + E E+++ R + R + + E + E+E + E ++ +E
Sbjct: 108 QRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEE 167
Query: 292 GQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQE 332
+K RE + KE +E R + E ER K R +++E
Sbjct: 168 REKKRE----RNRKERKKERERKERRERKKERKKERRKKKE 204
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/157 (20%), Positives = 74/157 (47%), Gaps = 2/157 (1%)
Query: 243 SQPAEEEEDQETPSRNLRVRADRNLKTEEEEEE-EEEEEEDDEEEEGDDEGQKSREAPIL 301
S+P + E + R R + R + E + E ++E+++ + E G + +K +E
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 302 KEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEM 361
++ + E E R K ++ + + + R + ++ ER R +++ + R+++++
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRK 145
Query: 362 KTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKK 398
+ E +RE K + KE+ + R ++RKK
Sbjct: 146 ERKREKERGKRERKRKKRKKEE-REKKRERNRKERKK 181
Score = 42.4 bits (98), Expect = 0.003
Identities = 42/194 (21%), Positives = 82/194 (42%), Gaps = 20/194 (10%)
Query: 138 KQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELE 197
K+ E+++E R+R ++E ++ + E E E + E + ER E E
Sbjct: 45 KRKREREKERKRERGKKEKKKRKKRERGK-ERERKRKERE----------KQRKERREKE 93
Query: 198 LSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSR 257
+ K +++G + +K ++ + R +Q R K + + +E + R
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153
Query: 258 NLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPE 317
R R K ++ ++EE E+ + E E +K RE +E K+E ++ R K E
Sbjct: 154 GKRER-----KRKKRKKEEREK----KRERNRKERKKERERKERRERKKERKKERRKKKE 204
Query: 318 EMMDERPKTRSQEQ 331
D + ++ Q
Sbjct: 205 RKKDRKTDRQTDSQ 218
Score = 37.4 bits (85), Expect = 0.098
Identities = 28/116 (24%), Positives = 51/116 (43%), Gaps = 5/116 (4%)
Query: 302 KEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQE--- 358
K+ + E E+ R + +E ER K ++++ ERG R ++E K R+++E
Sbjct: 37 KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRK 96
Query: 359 --KEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEE 412
KE K + RE K + KE+ + R + +K+ E+ +E
Sbjct: 97 RKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 107 bits (266), Expect = 1e-22
Identities = 75/216 (34%), Positives = 115/216 (53%), Gaps = 47/216 (21%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSE-REWDRDKVREGPRSRSRSRDRRRKE 1187
+H E +R RE+ E +RE +R + +++E R +RD+ R+ R+R R RDR R++
Sbjct: 8 RHTHTETETMDRQ-RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREK 66
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKE 1247
+ + ++ ++E+ ++ Q+E ER ER KE
Sbjct: 67 QTDREGERQRERERDRDR------------------------------QRETER-ERDKE 95
Query: 1248 REK-RRKEQEEEEQKEREKEAERERNRQLEREKR--------REHSRERDRERERERE-- 1296
RE R E + E QK++E+E ER R+R+ E++K RE RER+R+ ERERE
Sbjct: 96 RETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETG 155
Query: 1297 RDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRST 1332
R+R DR RER+RER RER+R KR ++ R R T
Sbjct: 156 RERKTEDRHRERERERKRERER---KRETKERERHT 188
Score = 98.6 bits (244), Expect = 4e-20
Identities = 68/213 (31%), Positives = 109/213 (51%), Gaps = 46/213 (21%)
Query: 1101 DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER-AVREQWAEREREMERRERT 1159
DR E+KTE++ R QR++ER R++ ERE++ +R
Sbjct: 32 DRAKESKTEDR-----------------HSERDRQRDRERNRERDRDREREKQTDREGER 74
Query: 1160 RSEREWDRDKVREGPRSRSRSRDRRR-----KERAKSKEKKSEKKEKAQEEPPAKLLDDL 1214
+ ERE DRD+ RE R R + R+ R +ER K KE++ E+ + E ++
Sbjct: 75 QRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQK----EM 130
Query: 1215 FRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQ 1274
R+ + TD + ++ +AER +E + RK ++ ++ERE++ ERER R+
Sbjct: 131 GRERQ----------TDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRE 180
Query: 1275 ---------LEREKRREHSRERDRERERERERD 1298
+ERE++RE R+RDR+RE ERERD
Sbjct: 181 TKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 77.8 bits (190), Expect = 7e-14
Identities = 58/182 (31%), Positives = 91/182 (50%), Gaps = 50/182 (27%)
Query: 1179 RSRDRRR---KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIV 1235
R R+RRR +ER ++KE K+E + ++
Sbjct: 19 RQRERRRETDRERDRAKESKTEDRHSERDR------------------------------ 48
Query: 1236 QKEAER-AERAKEREKRRK-EQEEEEQKEREKEAERERNRQLEREKRREHSR--ERDRER 1291
Q++ ER ER ++RE+ ++ ++E E Q+ERE++ +R+R + ER+K RE R E DRER
Sbjct: 49 QRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRER 108
Query: 1292 ERERERDRGDRDRDRER------------DRERGRERDRRDTKRHSRSRSRSTPVRDRGG 1339
++++ER+ +R RDRER DRE RER+R+ + R R T R R
Sbjct: 109 QKQKEREM-ERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRER 167
Query: 1340 RR 1341
R
Sbjct: 168 ER 169
Score = 56.6 bits (135), Expect = 2e-07
Identities = 45/186 (24%), Positives = 80/186 (43%), Gaps = 10/186 (5%)
Query: 188 QSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAE 247
+S E E R R+ + + + + + R+GER+ R R + +E + E
Sbjct: 36 ESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKE 95
Query: 248 EEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEE 307
E D+ T + R + + E E+++E E + D E + RE +E +E
Sbjct: 96 RETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERE-RET 154
Query: 308 GEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPL 367
G E K E+ ER + R +E+E R ++E R + + R++Q + +
Sbjct: 155 GRE---RKTEDRHRERERERKRERE------RKRETKERERHTDMERERQRETDRKRDRQ 205
Query: 368 EEEERE 373
E ERE
Sbjct: 206 RESERE 211
Score = 52.8 bits (125), Expect = 2e-06
Identities = 49/169 (28%), Positives = 73/169 (43%), Gaps = 10/169 (5%)
Query: 222 RKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLK--TEEEEEEEEEE 279
R+ ERR R+ AK S+ E + Q RN DR + T+ E E + E
Sbjct: 19 RQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRER 78
Query: 280 EED-DEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGG 338
E D D + E + E K RE E E R K +E ER + R +E++
Sbjct: 79 ERDRDRQRETERERDKERETDRHTETDRE-----RQKQKEREMERVRDREREKQKEMGRE 133
Query: 339 RFTRSQEEARKSHLARQQQE--KEMKTTSPLEEEEREIKSSQGLKEKSK 385
R T + + + A +++E +E KT E ERE K + K ++K
Sbjct: 134 RQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETK 182
Score = 52.8 bits (125), Expect = 2e-06
Identities = 50/198 (25%), Positives = 86/198 (43%), Gaps = 23/198 (11%)
Query: 197 ELSRHSPRKSSSISEEK-GDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETP 255
E R R S +E++ + D ++ R+ R R R+ EG + E E D+
Sbjct: 26 ETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDR--- 82
Query: 256 SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAP---ILKEFKEEGEEIP 312
DR +TE E ++E E D E D E QK +E + +E+ +E+
Sbjct: 83 --------DRQRETERER---DKERETDRHTETDRERQKQKEREMERVRDREREKQKEMG 131
Query: 313 RVKPEEMMDERPKTRSQEQEVLERGGRFT----RSQEEARKSHLARQQQEKEMKTTSPLE 368
R + + +R + R E+E R T R +E RK R+++ KE + + +E
Sbjct: 132 RERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDME 191
Query: 369 -EEEREIKSSQGLKEKSK 385
E +RE + + +S+
Sbjct: 192 RERQRETDRKRDRQRESE 209
Score = 49.3 bits (116), Expect = 2e-05
Identities = 50/204 (24%), Positives = 88/204 (43%), Gaps = 14/204 (6%)
Query: 200 RHSPRKSSSIS---EEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPS 256
RH+ ++ ++ E + ++D E+ R E ++ R + + + + E + D+E
Sbjct: 8 RHTHTETETMDRQRERRRETDRERDRAKESKTED-RHSERDRQRDRERNRERDRDREREK 66
Query: 257 RNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFK-EEGEEIPRVK 315
+ R + + + + + E E E D+E E D + RE KE + E + R K
Sbjct: 67 QTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREK 126
Query: 316 PEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIK 375
+EM ER R ++E ER R RK+ +++E+E K ERE K
Sbjct: 127 QKEMGRERQTDRETDRE-RERQAERERETGRERKTEDRHRERERERK-------RERERK 178
Query: 376 SSQGLKEKSKSPSPPRLTE-DRKK 398
+E+ R E DRK+
Sbjct: 179 RETKERERHTDMERERQRETDRKR 202
Score = 41.6 bits (96), Expect = 0.005
Identities = 40/175 (22%), Positives = 70/175 (40%), Gaps = 19/175 (10%)
Query: 240 SEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAP 299
+EG E E + R R DR +E + E+ E D + + + ++ R+
Sbjct: 5 TEGRHTHTETETMDR-QRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRE 63
Query: 300 ILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEK 359
K+ EGE R + E +R + +E++ R T + E +K Q+E+
Sbjct: 64 REKQTDREGE---RQRERERDRDRQRETERERDKERETDRHTETDRERQK------QKER 114
Query: 360 EMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEET 414
EM+ E E++ KE + R T DR++ +T E +T
Sbjct: 115 EMERVRDREREKQ--------KEMGRERQTDRET-DRERERQAERERETGRERKT 160
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 105 bits (262), Expect = 3e-22
Identities = 180/873 (20%), Positives = 339/873 (38%), Gaps = 147/873 (16%)
Query: 126 QIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEA-------SAESEDEMI---- 174
++G Q +++L + +RQRL+ EAR+ E E A + E+E +
Sbjct: 159 RLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQK 218
Query: 175 ---------------HPEGVASLLPPDFQSSLERPELELSRHSPRK---SSSISEEKGDS 216
H E V LL S + +++ K +S++ E +
Sbjct: 219 KAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQL 278
Query: 217 DDEKPRKGERRSS--RVRQAR---AAKLSEGSQPAEEEE----DQETPSRNLRVRADRNL 267
+ + + RVR R AAK++ + + +EE ++ +R + A ++
Sbjct: 279 EGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKST 338
Query: 268 KTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI----------LKEFKE----------- 306
K E + E E+ + E + +A + L+E+++
Sbjct: 339 KDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMALDIE 398
Query: 307 --------EGEE-------IPRVKPEEM-----MDERPKTRSQEQ-EVLERGGRFT---- 341
EGEE IP PE + + K +S+E+ +V+E+ + T
Sbjct: 399 IAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVE 458
Query: 342 RSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASL 401
EE + + +++EKE K EEE E + ++G +E++KSP K+A
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA-- 516
Query: 402 VALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADT 461
++ +EE P EA SP E P + +P SPP +
Sbjct: 517 -----KSPVKEEAKSP---AEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE 568
Query: 462 RELLVSQHTVQLVGGLSPLSSPSDTKAESPAE-KVPEESVLPLVQKSTLADYSAQKDLEP 520
+E S V+ SP+ +A+SPAE K PE++ P+ +++ S + P
Sbjct: 569 KEEAKSPAEVK---SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAK----SPAEAKSP 621
Query: 521 ESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSR 580
+ + P +K E AK T+E K P + + + S +S + ++
Sbjct: 622 VKEEAKSPAEVKSPE--KAKSPTKEEAKSPEKAKSPEKEEA----KSPEKAKSPVKAEAK 675
Query: 581 SSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSR 640
S + S ++ ++SP+ + S +S ++ + + A + K + +++ +
Sbjct: 676 SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEK 735
Query: 641 SRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQ---------EVATPPVPQLQVC 691
++S + + + K+ SP ++ E K P+ + E A PV + +V
Sbjct: 736 AKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKE-EVK 794
Query: 692 EPKERTSTSSSSVQA--RRLSQPESAEKHVTQRLQPE----RGSPKKCEAEEAEPPAATQ 745
P++ S +A + + + E + V + +P+ + PKK E E+A P
Sbjct: 795 SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKA-PATPKT 853
Query: 746 PQTSETQTSHLPESERIHHTVEEKEEVTM------------DTSENRPENDVPEPPMPIA 793
+ +++ P+ E VEEK+E + + +E++ + PE P
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAK 913
Query: 794 DQVSNDDRPEGSVE-------DEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPG 846
+V D +P+ E D + KE S P K TK A + +P
Sbjct: 914 VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE---KPK 970
Query: 847 RKRRWGASTATTQKKPSISITTESLKSLIPDIK 879
+ + T K+PS ++ KS D K
Sbjct: 971 TEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQK 1003
Score = 90.9 bits (224), Expect = 7e-18
Identities = 115/564 (20%), Positives = 229/564 (40%), Gaps = 59/564 (10%)
Query: 128 GEEMSQNSFIKQYLEKQQELLRQRLEREAREAAEL---EEASAESEDEMIHPEGVASLLP 184
GEE +++ ++ ++E + ++ EA+ AE E+ A+S E+ PE S
Sbjct: 497 GEEETKSPPAEEAASPEKEA-KSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 185 PDFQSSLER--PELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEG 242
+ +S E PE E ++ SP + S + K + +E E +S +A++ E
Sbjct: 556 EEAKSPPEAKSPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPAEAKSPE--KAKSPVKEEA 612
Query: 243 SQPAEEEEDQETPSRN-LRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPIL 301
PAE + + +++ V++ K+ +EE + E+ E+E +K++ +P+
Sbjct: 613 KSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAK-SPVK 671
Query: 302 KEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEM 361
E K + VK E E+ K+ +E+ +S E+A+ +++ +
Sbjct: 672 AEAKSPEKAKSPVKAEAKSPEKAKSPVKEE---------AKSPEKAKSP--VKEEAKSPE 720
Query: 362 KTTSPLEEEEREI-KSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT 420
K SP++EE + K+ +KE++KSP + E K + + +T ++EE P
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP--- 777
Query: 421 KEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL 480
A P + +EE++ E P+ P + +E ++ +
Sbjct: 778 --ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE--------EVKSPVKEE 827
Query: 481 SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK 540
P + K + P +K EE P K+ +KD + E + K+EE K
Sbjct: 828 EKPQEVKVKEPPKKAEEEKA-PATPKT-----EEKKDSKKEEAPKKEAPKPKVEE---KK 878
Query: 541 GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG 600
E K+ +E K+ +P+ + A + + ++ D+
Sbjct: 879 EPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKA 938
Query: 601 SRSHSPLRSKQ-----RDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKS 655
P K+ +D + + P +PK +++ + ++ S+ S+ + + KS
Sbjct: 939 KEPSKPAEKKEAAPEKKDTKEEKA-KKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKS 997
Query: 656 LSPGVSRDSSTSYTETKDPSSGQE 679
SST ++K P E
Sbjct: 998 --------SSTDQKDSKPPEKATE 1013
Score = 69.7 bits (169), Expect = 2e-11
Identities = 94/398 (23%), Positives = 171/398 (42%), Gaps = 46/398 (11%)
Query: 41 KLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQK--SAL 98
K P+ EA + + S AE + P++A + KA + AKS +K S +
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPV 712
Query: 99 VKRLKGALMLENLQKHS--TPHAAFQPNSQIGE--EMSQNSFIKQYLEKQQELLRQRLER 154
+ K ++ K TP A P + + E +++ + L+ + + +
Sbjct: 713 KEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772
Query: 155 EAREAAEL--EEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEE 212
EAR A+ E+A + ++E+ PE S L D ++ PE E+ + KS EE
Sbjct: 773 EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA----PEKEIPKKEEVKSPVKEEE 828
Query: 213 KGDSDD--EKPRKGERRSSRVRQARAAKLSEGSQPAEEEE--DQETPSRNLRVRADRNL- 267
K E P+K E +A A +E + +++EE +E P + + + +
Sbjct: 829 KPQEVKVKEPPKKAEE-----EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 268 KTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTR 327
K +E + E ++EE +D+++ E +EAP E KE+ + P+ K E E +
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPE----KEAPAKVEVKEDAK--PKEKTEVAKKEPDDAK 937
Query: 328 SQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSP 387
++E S+ +K ++ KE K P E+ + E K+ + K SK P
Sbjct: 938 AKEP-----------SKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEP 986
Query: 388 SPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASS 425
S P+ + K +S T ++ PP T++ ++
Sbjct: 987 SKPKAEKAEKSSS-------TDQKDSKPPEKATEDKAA 1017
Score = 65.1 bits (157), Expect = 4e-10
Identities = 116/613 (18%), Positives = 222/613 (36%), Gaps = 61/613 (9%)
Query: 736 EEAEPPAATQPQTSETQTSHLPESERIHHTVEEKE-EVTMDTSENRPENDVPEPPMPIAD 794
E+ E T+ T E + E + EE+E E + +++ P + P
Sbjct: 459 EQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS 518
Query: 795 QVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGAS 854
V + + + EK+E+ P K S K S E P ++ +
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK--EEAKSPPEAKSPEKEEAKSPA 576
Query: 855 TATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKG 914
+ +K S E KS P + V + A ++ + K
Sbjct: 577 EVKSPEKAK-SPAKEEAKSPAEAKSPEKAKSPVKE-EAKSPAEAKSPVKEEAKSPAEVKS 634
Query: 915 LKICRTVTQVVPAEGQENGQREEEEEEKEPE-AEPPVPPQVSVEVALPPPAEHEVKKVTL 973
+ ++ T+ A+ E + E+EE K PE A+ PV + P + E K
Sbjct: 635 PEKAKSPTKE-EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEK 693
Query: 974 GDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLG 1033
+ + + S PV+ + SP + K
Sbjct: 694 AKSPVKEEAKSPEKAKS-----PVKE-EAKSPEKAK------------------------ 723
Query: 1034 RTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELD 1093
+ EEA +K KS EEA + A K + K A ++E
Sbjct: 724 --SPVKEEAKTPEKAKS------PVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775
Query: 1094 YHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREM 1153
++ EE P P + P+ ++ E + V+E+ E+ +E+
Sbjct: 776 SPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE--EKPQEV 833
Query: 1154 ERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKS---KEKKSEKKEKAQEEPPAKL 1210
+ +E + E +K P++ + +D +++E K K K EKKE A E+P
Sbjct: 834 KVKEPPKKAEE---EKAPATPKTEEK-KDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 1211 LDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR---RKEQEEEEQKEREKEA 1267
++ K + A +P + + K E E AK +EK +KE ++ + KE K A
Sbjct: 890 VE---AKKEEAEDKKKVPTPEKEAPAK-VEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
Query: 1268 ERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRS 1327
E++ +++ + E +++ + + + E + D+ +E + + + ++ + S
Sbjct: 946 EKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Query: 1328 RSRSTPVRDRGGR 1340
+ D+ +
Sbjct: 1006 KPPEKATEDKAAK 1018
Score = 38.5 bits (88), Expect = 0.044
Identities = 34/205 (16%), Positives = 89/205 (43%), Gaps = 5/205 (2%)
Query: 85 EQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQ 144
E + K +K VK + E + +TP + +S+ EE + K +E++
Sbjct: 819 EVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSK-KEEAPKKEAPKPKVEEK 877
Query: 145 QELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPR 204
+E +E+ E ++ AE + ++ PE A + + + + E+++ P
Sbjct: 878 KE---PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPD 934
Query: 205 KSSSISEEK-GDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRA 263
+ + K + + P K + + + ++ +E +++ + PS+ +A
Sbjct: 935 DAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Query: 264 DRNLKTEEEEEEEEEEEEDDEEEEG 288
+++ T++++ + E+ +D+ +G
Sbjct: 995 EKSSSTDQKDSKPPEKATEDKAAKG 1019
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 104 bits (260), Expect = 5e-22
Identities = 64/200 (32%), Positives = 113/200 (56%), Gaps = 18/200 (9%)
Query: 1132 RAEQREQER-AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK 1190
R ++ E+ER RE+ + ERE R+R R RE DR RE R R + RDR+R +R +
Sbjct: 13 RGKETERERDRQRERENQTERENRHRQRDR-HRERDRQTDREKERERQKERDRQR-QRER 70
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK 1250
E+++E++ + Q + K D R D ++ +R +ER
Sbjct: 71 ETERETERQRERQRQRERKRQTDRER--------------DKDRDRERKRETDRNRERN- 115
Query: 1251 RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDR 1310
R+ +E ++Q ERE++ ERER RQ ERE++R+ R+R+ +RER+R +R +R ++R+++R
Sbjct: 116 RKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKER 175
Query: 1311 ERGRERDRRDTKRHSRSRSR 1330
++ R+ +++ KR + +
Sbjct: 176 KKERKEKKKEEKRREDKKRK 195
Score = 104 bits (259), Expect = 6e-22
Identities = 65/203 (32%), Positives = 111/203 (54%), Gaps = 31/203 (15%)
Query: 1144 EQWAEREREMERRERTRSEREWDRDKVREGPR-SRSRSRDRRRK-----ERAKSKEKKSE 1197
E+ ER+RE +R + T ER+ R++ + R +R R RDR R+ +R K +E++ E
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 1198 KKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEE 1257
+ + Q E + R+T+ Q+E +R K + R ++++
Sbjct: 62 RDRQRQRERETE------RETER---------------QRERQRQRERKRQTDRERDKDR 100
Query: 1258 EEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERD 1317
+ +++RE + RERNR+ RE+ ++ RERDRERER+R+R+R +R R RER RE RER
Sbjct: 101 DRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRER-ERQRQRERKRETDRERQ 159
Query: 1318 R---RDTKRHSRSRSRSTPVRDR 1337
R R+ ++ R + R +++
Sbjct: 160 RWAEREERKKERKKERKKERKEK 182
Score = 101 bits (251), Expect = 6e-21
Identities = 65/200 (32%), Positives = 110/200 (55%), Gaps = 31/200 (15%)
Query: 1135 QREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKE 1193
QRE++R R + ERER+ +R ++ERE +R + R+ R R R DR KER + KE
Sbjct: 4 QRERKRETDRGKETERERDRQRERENQTERE-NRHRQRDRHRERDRQTDRE-KERERQKE 61
Query: 1194 KKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
+ +++ + + E R+T+ Q+E +R K + R +
Sbjct: 62 RDRQRQRERETE----------RETER---------------QRERQRQRERKRQTDRER 96
Query: 1254 EQEEEEQKEREKEAERERNRQ--LEREKRREHSRERDRERERERERDR-GDRDRDRERDR 1310
+++ + +++RE + RERNR+ ER+K+ E R+R+RER+R+RER+R R+R RE DR
Sbjct: 97 DKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDR 156
Query: 1311 ERGRERDRRDTKRHSRSRSR 1330
ER R +R + K+ + +
Sbjct: 157 ERQRWAEREERKKERKKERK 176
Score = 92.4 bits (228), Expect = 3e-18
Identities = 47/106 (44%), Positives = 68/106 (64%), Gaps = 4/106 (3%)
Query: 1240 ERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDR 1299
+ ER ++R++ R+ Q E E + R+++ RER+RQ +REK RE +ERDR+R+RERE +R
Sbjct: 15 KETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETER 74
Query: 1300 -GDRDRDRERDRERGRERDRRDTKRHSRSRSRSTP---VRDRGGRR 1341
+R R+R+R RER R+ DR K R R R T R+R G R
Sbjct: 75 ETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGR 120
Score = 73.6 bits (179), Expect = 1e-12
Identities = 49/170 (28%), Positives = 91/170 (53%), Gaps = 34/170 (20%)
Query: 1129 QHPRAEQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKE 1187
Q R QR++ER RE +RER+ +R + +++RE D+D+ RE R R+R+R RK
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKG 118
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKE 1247
+ ++K++E++ + E Q++ ER ER ++
Sbjct: 119 -GRERDKQTERERDRERER-----------------------------QRQRER-ERQRQ 147
Query: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERER 1297
RE++R E + E Q+ E+E ER++ R+ ER+K R+ ++ ++ RE ++ +
Sbjct: 148 RERKR-ETDRERQRWAERE-ERKKERKKERKKERKEKKKEEKRREDKKRK 195
Score = 55.1 bits (131), Expect = 5e-07
Identities = 44/192 (22%), Positives = 84/192 (43%), Gaps = 21/192 (10%)
Query: 225 ERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLK----TEEEEEEEEEEE 280
ER+ R R+ K +E + + E + +T N + DR+ + T+ E+E E ++E
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 281 ED---DEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERG 337
D E E + E ++ RE +E K + + R + ++ ER + + +E +G
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTD---RERDKDRDRERKRETDRNRERNRKG 118
Query: 338 GRFTRSQEEARKSHLARQQQEKEMKTTSPLEEE-----------EREIKSSQGLKEKSKS 386
GR Q E + +Q+++E + E + ERE + + KE+ K
Sbjct: 119 GRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKE 178
Query: 387 PSPPRLTEDRKK 398
+ E R++
Sbjct: 179 RKEKKKEEKRRE 190
Score = 49.7 bits (117), Expect = 2e-05
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 12/68 (17%)
Query: 1275 LEREKRREHSRERDRERERERERDR------------GDRDRDRERDRERGRERDRRDTK 1322
+ER++ R+ +R +E ERER+R R RDR RERDR+ RE++R K
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 1323 RHSRSRSR 1330
R R R
Sbjct: 61 ERDRQRQR 68
Score = 48.9 bits (115), Expect = 3e-05
Identities = 45/198 (22%), Positives = 90/198 (45%), Gaps = 13/198 (6%)
Query: 196 LELSRHSPRKSSSISEEKGDSDDEKPRKGE-RRSSRVRQARAAKLSEGSQPAEEEEDQET 254
+E R R++ E + + D ++ R+ + R +R RQ + E + + E+++E
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHR--ERDRQTDREKERER 58
Query: 255 PSRNLRVRADRNLKTEEEEEEEEEEE-------EDDEEEEGDDEGQKSREAPILKEFKEE 307
R R R +TE E E + E + + D E + D + ++ RE +E +
Sbjct: 59 QKERDRQR-QRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRK 117
Query: 308 GEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPL 367
G R K E +R + R +++E ER + R +E R+ +++E++ +
Sbjct: 118 GGR-ERDKQTERERDRERERQRQRE-RERQRQRERKRETDRERQRWAEREERKKERKKER 175
Query: 368 EEEEREIKSSQGLKEKSK 385
++E +E K + +E K
Sbjct: 176 KKERKEKKKEEKRREDKK 193
Score = 45.8 bits (107), Expect = 3e-04
Identities = 39/191 (20%), Positives = 85/191 (44%), Gaps = 13/191 (6%)
Query: 195 ELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQET 254
E E R R++ + E + D + R+ +R++ R ++ K + + E E ++ET
Sbjct: 18 ERERDRQRERENQTERENRHRQRD-RHRERDRQTDREKERERQKERDRQRQRERETERET 76
Query: 255 PSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRV 314
+ R R + + + + E +++ D E + + + + R ++ G E +
Sbjct: 77 ERQRERQRQ----RERKRQTDRERDKDRDRERKRETDRNRERN-------RKGGRERDKQ 125
Query: 315 KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREI 374
E ER + R +E+E +R R + R+ R++++KE K E +E++
Sbjct: 126 TERERDRERERQRQRERE-RQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKK 184
Query: 375 KSSQGLKEKSK 385
+ + +K K
Sbjct: 185 EEKRREDKKRK 195
Score = 31.6 bits (70), Expect = 5.4
Identities = 19/76 (25%), Positives = 26/76 (34%)
Query: 571 KQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMG 630
++ D R + + R R R R R K RD + R R R + G
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKG 118
Query: 631 SRSTSESRSRSRSRSR 646
R + R R R R
Sbjct: 119 GRERDKQTERERDRER 134
Score = 31.6 bits (70), Expect = 5.4
Identities = 18/84 (21%), Positives = 26/84 (30%)
Query: 571 KQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMG 630
K+ D + R+R + G R ++RD + R R R +
Sbjct: 89 KRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRERERQRQRERERQRQR 148
Query: 631 SRSTSESRSRSRSRSRSASSNSRK 654
R R R R R RK
Sbjct: 149 ERKRETDRERQRWAEREERKKERK 172
Score = 30.8 bits (68), Expect = 9.1
Identities = 22/108 (20%), Positives = 36/108 (33%), Gaps = 3/108 (2%)
Query: 548 KQPSLEQKEGRRASHTLLPSHRLK-QSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSP 606
+Q E + R H HR + + D R R R R + R
Sbjct: 23 RQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETERQRE- 81
Query: 607 LRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRK 654
R +QR+ + + R + R T +R R+R R + +
Sbjct: 82 -RQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTER 128
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 104 bits (259), Expect = 6e-22
Identities = 70/201 (34%), Positives = 109/201 (54%), Gaps = 20/201 (9%)
Query: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERA---KSK 1192
RE+ER RE+ +R+R ER E E DRD+ R+ R R R RDR RK + +
Sbjct: 58 RERERQ-RERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDR 116
Query: 1193 EKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAE-RAERAKEREKR 1251
E ++E++E+ + + K D R+ + I K+ E E+ ++RE+
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIGI-----------DKDREIETEKDRDRERE 165
Query: 1252 RKEQEEEEQKEREKEAERERNRQLEREKRRE-HSRERDRERERERERDRGDRDRDRERDR 1310
E E +ERE++ +RE R +RE++RE RERDR+R++ERE+DR R+RE R
Sbjct: 166 MGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRY---RERETGR 222
Query: 1311 ERGRERDRRDTKRHSRSRSRS 1331
+R +ERDR + R R ++
Sbjct: 223 DRDKERDRERQREKDRDRQKA 243
Score = 103 bits (258), Expect = 8e-22
Identities = 72/207 (34%), Positives = 115/207 (55%), Gaps = 43/207 (20%)
Query: 1142 VREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
+RE+ ER+RE ER+ + ER ++D+ E R R R RDR R +R + +++K E+
Sbjct: 57 IRER--ERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRER-QRWRDRDRKRER--- 110
Query: 1202 AQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRR-------KE 1254
D R+T+ T+ Q ++ +R K+RE++R K+
Sbjct: 111 ---------WGDRDRETE----------TERQEERERQRDRKREKDRERQRQREIGIDKD 151
Query: 1255 QEEEEQKEREKE-----AERERNRQLEREKRREHSRERDRERERE---RERDRG---DRD 1303
+E E +K+R++E ER R+R+ ER+K+RE R+RDRER+RE RERDR +R+
Sbjct: 152 REIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKERE 211
Query: 1304 RDRERDRERGRERDRRDTKRHSRSRSR 1330
+DR R+RE GR+RD+ + R + R
Sbjct: 212 KDRYRERETGRDRDKERDRERQREKDR 238
Score = 93.2 bits (230), Expect = 1e-18
Identities = 62/196 (31%), Positives = 109/196 (55%), Gaps = 27/196 (13%)
Query: 1122 PPPVQPPQHPRAEQREQERAVREQWAEREREMER-----RERTRSEREW-DRDKVREGPR 1175
P ++ + R +R+++RA +E+ E++RE+E+ R+R R + W DRD+ RE
Sbjct: 54 PAIIRERERQRERERQRKRA-KERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWG 112
Query: 1176 SRSRSRD-RRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQI 1234
R R + R++ER + +++K EK + Q + + D +T+ D +
Sbjct: 113 DRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKD--------RDRER 164
Query: 1235 VQKEAER-----AERAKEREKRR------KEQEEEEQKEREKEAERERNRQLEREKRREH 1283
E ER ER K+RE RR + ++E+ +++R+++ ERE++R ERE R+
Sbjct: 165 EMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDR 224
Query: 1284 SRERDRERERERERDR 1299
+ERDRER+RE++RDR
Sbjct: 225 DKERDRERQREKDRDR 240
Score = 88.2 bits (217), Expect = 5e-17
Identities = 63/194 (32%), Positives = 103/194 (53%), Gaps = 20/194 (10%)
Query: 1129 QHPRAEQREQER-----AVREQWAEREREMER-RERTRSEREW-DRDKVREGPRSRSRSR 1181
Q RA++R +E+ R++ +R+RE +R R+R R W DRD+ E R R R
Sbjct: 69 QRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERER 128
Query: 1182 DRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAER 1241
R RK R K +E++ +++ ++ + D R+ + + + Q+E R
Sbjct: 129 QRDRK-REKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRR 187
Query: 1242 -AERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRG 1300
+R ++REK +E++ + QKEREK+ RE RE R+RD+ER+RER+R++
Sbjct: 188 DRDRERQREKEDRERDRDRQKEREKDRYRE----------RETGRDRDKERDRERQREK- 236
Query: 1301 DRDRDRERDRERGR 1314
DRDR + D GR
Sbjct: 237 DRDRQKAIDCVPGR 250
Score = 84.7 bits (208), Expect = 5e-16
Identities = 56/177 (31%), Positives = 92/177 (51%), Gaps = 38/177 (21%)
Query: 1170 VREGPRSRSRSRDRRR-KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLP 1228
+RE R R R R R+R KER + K+++ EK Q +
Sbjct: 57 IRERERQRERERQRKRAKERHREKDREIEKDRDRQRKR---------------------- 94
Query: 1229 LTDSQIVQKEAER-AERAKEREK---RRKEQEEEEQKEREKEAERERNRQLEREKRREHS 1284
+E +R +R ++RE+ R +E E E Q+ERE++ +R+R + ER+++RE
Sbjct: 95 -------DRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIG 147
Query: 1285 RERDRERERERERDR----GDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
++DRE E E++RDR G+ +R R+R+RER ++R+ R + R R + RDR
Sbjct: 148 IDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDR 204
Score = 56.2 bits (134), Expect = 2e-07
Identities = 57/196 (29%), Positives = 90/196 (45%), Gaps = 28/196 (14%)
Query: 222 RKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVR---ADRNLKTE-------- 270
R+ ER+ R RQ + AK + E E+D++ + R R DR+ K E
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRE 117
Query: 271 -EEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQ 329
E E +EE E + D + E D E Q+ RE I K+ + E E+ R + E M E + R +
Sbjct: 118 TETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEK-DRDRERE-MGETERYRDR 175
Query: 330 EQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEERE---IKSSQGLKEKSKS 386
E+E + Q E R+ +Q+EKE + ++ERE + + +++ K
Sbjct: 176 ERE--------RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKE 227
Query: 387 PSPPRLTE---DRKKA 399
R E DR+KA
Sbjct: 228 RDRERQREKDRDRQKA 243
Score = 54.7 bits (130), Expect = 6e-07
Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 4/163 (2%)
Query: 195 ELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQET 254
E+E R RK + D D ++ R G+R R + + E + + E+D+E
Sbjct: 83 EIEKDRDRQRKRDRERQRWRDRDRKRERWGDR--DRETETERQEERERQRDRKREKDRER 140
Query: 255 P-SRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPR 313
R + + DR ++TE++ + E E E + + + E QK RE ++ + + E+ R
Sbjct: 141 QRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDR 200
Query: 314 VKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQ 356
+ + ER K R +E+E R R +E R+ RQ+
Sbjct: 201 ERDRDRQKEREKDRYRERET-GRDRDKERDRERQREKDRDRQK 242
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 103 bits (257), Expect = 1e-21
Identities = 182/767 (23%), Positives = 267/767 (34%), Gaps = 148/767 (19%)
Query: 159 AAELEEASAESEDEMIHPEGVASLLPPDF-QSSLERPELELSRHSPRKSSSISEEKGDSD 217
+A LE E + I E +AS+ D + ++ E E SR +S S K S
Sbjct: 121 SAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSP 180
Query: 218 DEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEE 277
+ RRSS VR+ R K S P T SR+ ++ KT E E
Sbjct: 181 SPR-----RRSSPVRRER--KRSHSRSPRHR-----TKSRSPSPAPEKKEKTPELPEPSV 228
Query: 278 EEEEDD-EEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLER 336
+ +E +E + K + + E KE E K +E RP++RS+ +
Sbjct: 229 KVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRT 288
Query: 337 GGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396
R + S R+ H +R + + SP R S + + P PPR R
Sbjct: 289 RSR-SPSHTRPRRRHRSRSRSYSPRRRPSP-----RRRPSPRRRTPPRRMPPPPRHRRSR 342
Query: 397 -----KKASLVALP----EQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPP 447
++ S +L ++S +PP K SSPP + S P P
Sbjct: 343 SPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRP- 401
Query: 448 VLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKS 507
SPP T P + S T +S + SV P
Sbjct: 402 -----SPPATPP-------------------PKTRHSPTPQQSNRTRKSRVSVSP---GR 434
Query: 508 TLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPS 567
T + K E S P P K+E S E K G+ A+ +
Sbjct: 435 TSGKVTKHKGTEKRESPSPAPKPRKVE-------------LSESEEDKGGKMAAADSVQQ 481
Query: 568 HRLKQSADSSSSRSSSSSSSSS-----RSRSRSPDSSGSRSHSPLRSKQRDVAQARTHAN 622
R + + SS S SSSSS RS ++ + R HSP RS + + +
Sbjct: 482 RRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETS 541
Query: 623 PRGR---------------------PKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS 661
PRGR P+ T R R+ S S S + SP +
Sbjct: 542 PRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQ 601
Query: 662 RDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQ---PESAEKH 718
R S S P + A+PP P PK R S S RR+S P+
Sbjct: 602 RRYSPS------PPPKRRTASPPPP------PKRRASPSPP--PKRRVSHSPPPKQRSSP 647
Query: 719 VTQRLQP------ERGSPKKCEAEEAEPP-------AATQPQTSETQTSHLPESERIHHT 765
VT+R P +GS EA P + +P+ +T +S P +
Sbjct: 648 VTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSS 707
Query: 766 VEEKEEVTMDTSENRPENDVPEP--------PMP-IADQVSNDDRPEGSVEDEEKKESSL 816
+ ++ + T R + PEP P P +VS+ GS E KK +
Sbjct: 708 PQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAP 767
Query: 817 PKSFKRKISVVSATKGVPA-------------GNSDTEGGQPGRKRR 850
P + + + + VP NSD EGG +K++
Sbjct: 768 PSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKK 814
Score = 74.3 bits (181), Expect = 7e-13
Identities = 64/215 (29%), Positives = 94/215 (43%), Gaps = 23/215 (10%)
Query: 1135 QREQERAVREQWAEREREMERRERTRSEREWDR----DKVREGP----RSRSRSRDRRRK 1186
+++ E + E+E E+RER+RS R + R P R RS SR R +
Sbjct: 145 KKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHR 204
Query: 1187 ERAKSKEKKSEKKEKAQE--EPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAER 1244
+++S EKKEK E EP K+ + ++ + I +P + KE +
Sbjct: 205 TKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKN 264
Query: 1245 AKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDR 1304
+K+ E+E++K R + R ++R R + H+R R R R R R R
Sbjct: 265 SKK--------EKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPS 316
Query: 1305 DRERDRERGRERDRR--DTKRHSRSRSRSTPVRDR 1337
R R R R RR RH RSRS PVR R
Sbjct: 317 PRRRPSPRRRTPPRRMPPPPRHRRSRS---PVRRR 348
Score = 44.3 bits (103), Expect = 8e-04
Identities = 32/100 (32%), Positives = 48/100 (48%), Gaps = 9/100 (9%)
Query: 1226 WLPLTDSQIVQKEAERAERA---KEREKRRKEQEEEEQKEREKEAERERNRQLEREKRRE 1282
+L L +I Q++ E+ + A K+ E + K +EE++ REK RER+R R K R
Sbjct: 123 FLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREK---RERSRSPRRRKSRS 179
Query: 1283 HS---RERDRERERERERDRGDRDRDRERDRERGRERDRR 1319
S R RER+R R R R + R E+ +
Sbjct: 180 PSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEK 219
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/89 (32%), Positives = 48/89 (53%), Gaps = 4/89 (4%)
Query: 1243 ERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDR 1302
E KE K+R+ ++E+ ++++ ++++ + E+E RE RER R R + R R
Sbjct: 125 ELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSRE-KRERSRSPRRRKSRSPSPR 183
Query: 1303 DRDRERDRERGRERDRRDTKRHSRSRSRS 1331
R RER R R + RH R++SRS
Sbjct: 184 RRSSPVRRERKRSHSR--SPRH-RTKSRS 209
Score = 42.4 bits (98), Expect = 0.003
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 2/94 (2%)
Query: 1117 LHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMER-RERTRSEREWDRDKVREGPR 1175
L P P P+ P+ P E+ ++ +E+ R R + R RTRS R + R R
Sbjct: 245 LKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRS-RSPSHTRPRRRHR 303
Query: 1176 SRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAK 1209
SRSRS RR+ + + + + PP +
Sbjct: 304 SRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPR 337
Score = 39.7 bits (91), Expect = 0.020
Identities = 26/81 (32%), Positives = 41/81 (50%), Gaps = 2/81 (2%)
Query: 1258 EEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERD 1317
E +KE K+ + E+ + +K+ E +RD+E E+E R++ +R R R + R
Sbjct: 125 ELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKE-EKESSREKRERSRSPRRRKSRSPSPR 183
Query: 1318 RRDTK-RHSRSRSRSTPVRDR 1337
RR + R R RS S R R
Sbjct: 184 RRSSPVRRERKRSHSRSPRHR 204
Score = 37.7 bits (86), Expect = 0.075
Identities = 53/236 (22%), Positives = 77/236 (32%), Gaps = 44/236 (18%)
Query: 1115 RPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGP 1174
R PP PP + PR +R A RR S K R P
Sbjct: 366 RSRSPPKKPPKRTSSPPRKTRRLSPSA----------SPPRRRHRPSPPATPPPKTRHSP 415
Query: 1175 RSRSRSRDRR--------RKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYW 1226
+ +R R+ R +K K +EK+E P + ++
Sbjct: 416 TPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVE-------------- 461
Query: 1227 LPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRE 1286
L ++ K A + R+ RR+ Q+ +E ER +R H +
Sbjct: 462 LSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDER-------PKRSHVKN 514
Query: 1287 RDRERERERERDRGDRDRDRERDRE---RGRER--DRRDTKRHSRSRSRSTPVRDR 1337
+ R R R R+R +E RGR R R RS S + P R R
Sbjct: 515 GEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRR 570
Score = 37.0 bits (84), Expect = 0.13
Identities = 51/248 (20%), Positives = 90/248 (36%), Gaps = 42/248 (16%)
Query: 1128 PQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKE 1187
P H R +R + R+ ++ R R RR + R R RSRS RRR+
Sbjct: 293 PSHTRPRRRHRSRS--RSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRR 350
Query: 1188 RAK----SKEKKSEKKEKAQEEPPAKLLDDLFRKT--------------KAAPCIYWLPL 1229
+ S S + ++ + P K RKT + +P P
Sbjct: 351 SSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPK 410
Query: 1230 TDSQIVQKEAERAERA--------------KEREKRRKEQEEEEQKERE---KEAERERN 1272
T +++ R ++ K + ++E K R+ E+E ++
Sbjct: 411 TRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKG 470
Query: 1273 RQL---EREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRS 1329
++ + ++R R ++++ + D +R + E RR +RHS SRS
Sbjct: 471 GKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRR--RRHSPSRS 528
Query: 1330 RSTPVRDR 1337
S R R
Sbjct: 529 ASPSPRKR 536
Score = 34.7 bits (78), Expect = 0.63
Identities = 47/221 (21%), Positives = 72/221 (32%), Gaps = 43/221 (19%)
Query: 1114 PRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREG 1173
PR H P PP PP+ + +Q RTR R G
Sbjct: 395 PRRRHRPSPPATPPPKTRHSPTPQQS-----------------NRTRKSRVSVSPGRTSG 437
Query: 1174 PRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQ 1233
++ + ++R K +K E E ++E+ K + DS
Sbjct: 438 KVTKHKGTEKRESPSPAPKPRKVELSE-SEEDKGGK-----------------MAAADSV 479
Query: 1234 IVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRE-RE 1292
+++ R + + E+E+ +R E R RR HS R
Sbjct: 480 QQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGR------RRRHSPSRSASPSP 533
Query: 1293 RERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTP 1333
R+R+++ R R R R R RR R R TP
Sbjct: 534 RKRQKETSPRGR-RRRSPSPPPTRRRRSPSPAPPPRRRRTP 573
Score = 32.3 bits (72), Expect = 3.1
Identities = 32/170 (18%), Positives = 59/170 (34%), Gaps = 27/170 (15%)
Query: 1112 GIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVR 1171
G P P PP P P Q ++ W+ + + T S
Sbjct: 755 GSPEPAAKKPPAPPSPVQ---------SQSPSTNWSPAVPVKKAKSPTPSPSP------- 798
Query: 1172 EGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTD 1231
PR+ + ++K++ K K+ K +KK K ++ +K KA +T
Sbjct: 799 --PRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKK---------HKKEKAVAAAAAAAVTP 847
Query: 1232 SQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRR 1281
+ I A+ K++ E E ++ + E+ + R R+
Sbjct: 848 AAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRK 897
>gi|38788333 remodeling and spacing factor 1 [Homo sapiens]
Length = 1441
Score = 102 bits (253), Expect = 3e-21
Identities = 258/1289 (20%), Positives = 477/1289 (37%), Gaps = 198/1289 (15%)
Query: 130 EMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQS 189
++ Q+ ++ Y+E+Q + + R EL E A + + I P + + D S
Sbjct: 166 QLDQDHNVRMYIEEQDDQDGSSWKCIVRNRNELAETLALLKAQ-IDPVLLKNSSQQD-NS 223
Query: 190 SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEE 249
S E P LE + + EE+ +S EK + E+ ++ A L E + E+E
Sbjct: 224 SRESPSLEDEETKKEEETPKQEEQKES--EKMKSEEQPMDLENRSTANVLEETTVKKEKE 281
Query: 250 EDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGE 309
+++E + V+ ++ L EE++ +EE + +E PI E KE
Sbjct: 282 DEKELVKLPVIVKLEKPLPENEEKKIIKEESDSFKE----------NVKPIKVEVKE--- 328
Query: 310 EIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEE 369
R P++ K +QE E +E GG S E KS ++ + + + PL
Sbjct: 329 --CRADPKDTKSSMEKPVAQEPERIEFGGNIKSSHEITEKSTEETEKLKNDQQAKIPL-- 384
Query: 370 EEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEET-------------PP 416
++REIK S K P +T ++ L ++ EEET
Sbjct: 385 KKREIKLSDDFDSPVKGPLCKSVTPTKE-----FLKDEIKQEEETCKRISTITALGHEGK 439
Query: 417 PLLTKEASSPPPHPQLHSE-------EEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQH 469
L+ E S P +E E E P+ I ++ N ++ S
Sbjct: 440 QLVNGEVSDERVAPNFKTEPIETKFYETKEESYSPSKDRNI-ITEGNGTESLNSVITSMK 498
Query: 470 TVQLVGGLSPLSSPSDTK---AESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESD-RS 525
T +L +PL +D+ E ++K E P +++L KDL ++ S
Sbjct: 499 TGELEKETAPLRKDADSSISVLEIHSQKAQIEEPDPPEMETSLDSSEMAKDLSSKTALSS 558
Query: 526 AQPLPLKIEELALAKGITEECLKQPSLEQKEG-RRASHTLL--PSHRLKQSADSSSSRSS 582
+ +K EE + T++ + P LE E ++ T L + RL + +
Sbjct: 559 TESCTMKGEEKSPK---TKKDKRPPILECLEKLEKSKKTFLDKDAQRLSPIPEEVPKSTL 615
Query: 583 SSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSR 642
S S + + S H + +++V + ++ + G+ + E+
Sbjct: 616 ESEKPGSPEAAETSPPSNIIDHCEKLASEKEVVECQSTSTVGGQSV--KKVDLETLKEDS 673
Query: 643 SRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSS 702
++ N + + G+ S ETK + VP+ +E T++ ++
Sbjct: 674 EFTKVEMDNLDNAQTSGIEEPS-----ETKGSMQKSKFKYKLVPE------EETTASENT 722
Query: 703 SVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERI 762
+ + R Q E + +T R+ + P PP +P+ + +T E +
Sbjct: 723 EITSER--QKEGIK--LTIRISSRKKKPD-------SPPKVLEPENKQEKTEKEEEKTNV 771
Query: 763 HHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKES-SLPKSFK 821
T+ + +RP V E I DQ ++ R EG EDE ++ES +L K+ K
Sbjct: 772 GRTLRRSPRI------SRPTAKVAE----IRDQKADKKRGEG--EDEVEEESTALQKTDK 819
Query: 822 RKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPL 881
++I K NS +P K RW S + K S + +E S K
Sbjct: 820 KEI----LKKSEKDTNSKVSKVKPKGKVRWTGSRTRGRWKYSSNDESEGSGS----EKSS 871
Query: 882 AGQEAVVDLHADDSRISEDETE----------------RNGDDGTHDKGLK--------- 916
A E + ++++ +++D+ + D G H L+
Sbjct: 872 AASEEEEEKESEEAILADDDEPCKKCGLPNHPELILLCDSCDSGYHTACLRPPLMIIPDG 931
Query: 917 --ICRTVTQVVPAEGQENGQRE-----EEEEEKEPEAEPPVPPQVSVEVALPP-----PA 964
C + E E ++ +++E E E V +S+E +PP
Sbjct: 932 EWFCPPCQHKLLCEKLEEQLQDLDVALKKKERAERRKERLVYVGISIENIIPPQEPDFSE 991
Query: 965 EHEVKK----------VTLGDTLTRRSISQQ----KSGVSITIDDPVRTAQVPSPPRGKI 1010
+ E KK + T TR+ IS + + I+D ++ A RGK
Sbjct: 992 DQEEKKKDSKKSKANLLERRSTRTRKCISYRFDEFDEAIDEAIEDDIKEADGGGVGRGK- 1050
Query: 1011 SNIVHISNLVRPFTLGQLKELLGRTG----TLVEEAFWIDKIKSHCFVTYSTVEEAVATR 1066
+ + G G T+++E +K +
Sbjct: 1051 ----------------DISTITGHRGKDISTILDEERKENKRPQRAAAARRKKRRRLNDL 1094
Query: 1067 TALHGVKWPQSNPKFLCADYAEQDEL----DYHRGLLVDRPSETKTEEQGIPRPLHPPPP 1122
+ + +S +F +D QDE + D PS ++ R L P
Sbjct: 1095 DSDSNLDEEESEDEFKISD-GSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPS 1153
Query: 1123 PPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRD 1182
P+ R +R + + ++++++ + E E E +R D + R R
Sbjct: 1154 RPM------RQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDDFSDDFVETRRRRS 1207
Query: 1183 RRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERA 1242
RR ++R + ++ SE + K + + ++ ++ ++ + K +E
Sbjct: 1208 RRNQKRQINYKEDSESDGSQKSLRRGKEIRRVHKRRLSS------SESEESYLSKNSEDD 1261
Query: 1243 ERAKE--REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRG 1300
E AKE R R++ + +E E ++E E E + ++R H E D E + G
Sbjct: 1262 ELAKESKRSVRKRGRSTDEYSEADEEEEEEEGKP---SRKRLHRIETDEEESCDNA--HG 1316
Query: 1301 DRDRDRERDRERGRERDRRDTKRHSRSRS 1329
D ++ + R ++ TK+ R S
Sbjct: 1317 DANQPARDSQPRVLPSEQESTKKPYRIES 1345
Score = 53.1 bits (126), Expect = 2e-06
Identities = 71/308 (23%), Positives = 116/308 (37%), Gaps = 48/308 (15%)
Query: 141 LEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSR 200
+ + + L R+ +++ + E EE+ S D S DF SR
Sbjct: 1156 MRQSRRLRRKTPKKKYSDDDEEEESEENSRDS-------ESDFSDDFSDDFVETRRRRSR 1208
Query: 201 HSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS----EGSQPAEEEEDQETPS 256
+ ++ + E DS+ + +K RR +R+ +LS E S ++ ED E
Sbjct: 1209 RNQKRQINYKE---DSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAK 1265
Query: 257 RNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREA--PILKEFKEEGEEIPRV 314
+ R R T+E E +EEEEE +EG+ SR+ I + +E +
Sbjct: 1266 ESKRSVRKRGRSTDEYSEADEEEEE--------EEGKPSRKRLHRIETDEEESCDNAHGD 1317
Query: 315 KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREI 374
+ D +P+ EQE ++ R +EE E K SPL+ ++
Sbjct: 1318 ANQPARDSQPRVLPSEQESTKKPYRIESDEEE---------DFENVGKVGSPLDYSLVDL 1368
Query: 375 KSSQGLKEKSKSPSPPRLTEDRKKASLVALP---EQTASEEETPPPLLTKEASSPPPHPQ 431
S+ G SP + E +L+ P QT + T L +S
Sbjct: 1369 PSTNG-------QSPGKAIE-----NLIGKPTEKSQTPKDNSTASASLASNGTSGGQEAG 1416
Query: 432 LHSEEEIE 439
EEE E
Sbjct: 1417 APEEEEDE 1424
Score = 48.9 bits (115), Expect = 3e-05
Identities = 72/344 (20%), Positives = 137/344 (39%), Gaps = 45/344 (13%)
Query: 207 SSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLR------ 260
S++ EE +S+DE + V SE P+ ++ D + SR LR
Sbjct: 1098 SNLDEE--ESEDEFKISDGSQDEFVVSDENPDESEEDPPSNDDSDTDFCSRRLRRHPSRP 1155
Query: 261 VRADRNL--KTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEE 318
+R R L KT +++ +++EEE+ EE D E S + +F E R +
Sbjct: 1156 MRQSRRLRRKTPKKKYSDDDEEEESEENSRDSESDFSDD--FSDDFVETRRRRSRRNQKR 1213
Query: 319 MMDERPKTRSQ-EQEVLERGGRFTR------SQEEARKSHLARQQQEKEM---------- 361
++ + + S Q+ L RG R S E+ +S+L++ ++ E+
Sbjct: 1214 QINYKEDSESDGSQKSLRRGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRK 1273
Query: 362 --KTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLL 419
++T E + E + +G + + R+ D +++ A + ++ P +L
Sbjct: 1274 RGRSTDEYSEADEEEEEEEGKPSRKRL---HRIETDEEESCDNAHGDANQPARDSQPRVL 1330
Query: 420 TKEASSPPPHPQLHSEEE-----IEPMEGPAPPVLIQLSPPNTDADTR--ELLVSQHTVQ 472
E S ++ S+EE + + P L+ L N + + E L+ + T +
Sbjct: 1331 PSEQESTKKPYRIESDEEEDFENVGKVGSPLDYSLVDLPSTNGQSPGKAIENLIGKPTEK 1390
Query: 473 LV----GGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADY 512
+ S S+ + PEE L++ + L DY
Sbjct: 1391 SQTPKDNSTASASLASNGTSGGQEAGAPEEEEDELLRVTDLVDY 1434
Score = 37.4 bits (85), Expect = 0.098
Identities = 35/192 (18%), Positives = 70/192 (36%), Gaps = 24/192 (12%)
Query: 1150 EREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQE---EP 1206
E E + S+ ++ ++R P R R R++ K K +++E+++E +
Sbjct: 1128 ESEEDPPSNDDSDTDFCSRRLRRHPSRPMRQSRRLRRKTPKKKYSDDDEEEESEENSRDS 1187
Query: 1207 PAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKE 1266
+ DD V+ R+ R ++R+ KE E + ++
Sbjct: 1188 ESDFSDDF----------------SDDFVETRRRRSRRNQKRQINYKEDSESDGSQKSLR 1231
Query: 1267 AERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERD-RERGRERDRRDTKRHS 1325
R +++ R +R S E + + + ++ +R R+RGR D
Sbjct: 1232 ----RGKEIRRVHKRRLSSSESEESYLSKNSEDDELAKESKRSVRKRGRSTDEYSEADEE 1287
Query: 1326 RSRSRSTPVRDR 1337
P R R
Sbjct: 1288 EEEEEGKPSRKR 1299
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 100 bits (248), Expect = 1e-20
Identities = 149/624 (23%), Positives = 251/624 (40%), Gaps = 74/624 (11%)
Query: 106 LMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEA 165
L++ LQK Q ++ E + I+Q LE Q E R+++E E RE E E
Sbjct: 148 LLMGTLQKFK------QESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFE-ERR 200
Query: 166 SAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGE 225
+ ++E ++ + + L ++ + + + I + + + +
Sbjct: 201 AKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQ 260
Query: 226 RRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEE 285
R+ + + + R + +E E +++ ++ + + ++ EE++ E+EE + E
Sbjct: 261 RKMNALFEGRRIEFAEQINKMEARPRRQS----MKEKEHQVVRNEEQKAEQEEGKVAQRE 316
Query: 286 EEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQE 345
EE ++ G + + I + +EE +EI V + ++ + + QE EV +
Sbjct: 317 EELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVK------MEEET 370
Query: 346 EARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALP 405
E R+S + Q +E+ + E + + + Q + E ++ S + +AS P
Sbjct: 371 EVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVES---VEPSENEASKELEP 427
Query: 406 EQTASEEETPPPLLTKEASSPPPHPQ--------LHSEEEIEPMEGPAPPVLIQLSPPNT 457
E E E P KE S P + SEE+ E P P + Q P
Sbjct: 428 EM---EFEIEPD---KECKSLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQ-- 479
Query: 458 DADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKD 517
SQ +QL S S +S PE+ L ++Q + Q
Sbjct: 480 ---------SQPQLQL-------QSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQE-QGH 522
Query: 518 LEPESDRSAQPLP-LKIEELALAKGIT---EECLKQPSLEQKEGRRASHTLLPSHRLKQS 573
L PE R P+ +K+ E+ + +T E K + + GR + T R S
Sbjct: 523 LLPE--RKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSS 580
Query: 574 ADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRS 633
+ SSSS +SSSS SSS S S S SS S S S S RD + + + S
Sbjct: 581 SSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTS-------------S 627
Query: 634 TSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEP 693
+SESRSRSR R + R+S+ RD+S K G T
Sbjct: 628 SSESRSRSRGRGHNRDRKHRRSVD-RKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSD 686
Query: 694 KERTSTSSSSVQARRLSQPESAEK 717
++R S S SS +R S+ E K
Sbjct: 687 RKR-SISESSRSGKRSSRSERDRK 709
Score = 52.4 bits (124), Expect = 3e-06
Identities = 81/446 (18%), Positives = 158/446 (35%), Gaps = 57/446 (12%)
Query: 923 QVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSI 982
QVV E Q+ Q E + ++E E E VE+ E + + D +
Sbjct: 296 QVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEE 355
Query: 983 SQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEA 1042
+QK + + +++ + + ++ + +V +K ++ +E
Sbjct: 356 EEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVE-----NVKHVIAD-----QEV 405
Query: 1043 FWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDR 1102
++++S V S E + + P K L LD +++
Sbjct: 406 METNRVES---VEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALD------MEK 456
Query: 1103 PSETKTEEQGIPRPLHPPPPPPVQPPQ-------------HPRAEQREQERAVREQWAER 1149
SE K E++ P+P P P PQ P ++ + AV + +
Sbjct: 457 ESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQV 516
Query: 1150 EREMERRERTRSEREWDRDKVREGP---------------RSRSRSRDRRRKERAKSKEK 1194
+E R + + K+ E P ++RSRSR R R + +KS+ +
Sbjct: 517 TQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSR 576
Query: 1195 KSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKE 1254
S + + + ++ + S + + R
Sbjct: 577 SSSSSSSSSSSTSSSSGSSSSSGSSSS-------RSSSSSSSSTSGSSSRDSSSSTSSSS 629
Query: 1255 QEEEEQKEREKEAERERNRQLEREKRREHSRERDRERER-ERERD-RGDRDRDRERDRER 1312
+ + R +R+ R ++R++R ER + + RD +G +D++ DR+R
Sbjct: 630 ESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKR 689
Query: 1313 GRERDRRDTKRHSRS-RSRSTPVRDR 1337
R KR SRS R R + +D+
Sbjct: 690 SISESSRSGKRSSRSERDRKSDRKDK 715
Score = 50.8 bits (120), Expect = 9e-06
Identities = 132/699 (18%), Positives = 258/699 (36%), Gaps = 96/699 (13%)
Query: 221 PRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEE 280
P G R S + + R S G PA++ + + SR L E E +E
Sbjct: 50 PGGGRGRGSLLLR-RGFSDSGGGPPAKQRDLEGAVSR---------LGGERRTRRESRQE 99
Query: 281 EDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRF 340
D E+ DD + + ++ ++ KE + ++ MDE+ K R++ L G
Sbjct: 100 SDPED---DDVKKPALQSSVVATSKERTRR--DLIQDQNMDEKGKQRNRRIFGLLMGTLQ 154
Query: 341 TRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQG--LKEKSKSPSPPRLTEDRKK 398
QE + +++QE E K EEE +++++ + +E+ + RL E +K
Sbjct: 155 KFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLE--QK 212
Query: 399 ASLVALPEQTASEE---------ETPPPLLTKEASSPPPHPQLHSEEEIEP---MEGPAP 446
L L E+ +T P L P +L E + + EG
Sbjct: 213 VELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRI 272
Query: 447 PVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEE-------- 498
Q++ +A R + + Q+V + + K E++ E
Sbjct: 273 EFAEQIN--KMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVE 330
Query: 499 -SVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPS-----L 552
++ +A + + E E + Q + +K+EE + ++ QP L
Sbjct: 331 IEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVL 390
Query: 553 EQKEGRR---ASHTLLPSHRLKQSADSSSSRSSS-------SSSSSSRSRSRSPDSSG-S 601
E E + A ++ ++R++ S + S +S SP S
Sbjct: 391 EMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVS 450
Query: 602 RSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLS---- 657
S++++ ++ P +P+ S+ + +S+S+ +S + + LS
Sbjct: 451 ALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVL 510
Query: 658 ---PGVSRDSSTSYTETKD-PSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPE 713
P V+++ E KD P ++ PV + P+ S S + R S+
Sbjct: 511 QPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPE-----SKSKTKTRSRSRGR 565
Query: 714 SAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVT 773
+ K R + S + + +++ +S +++S S + + T
Sbjct: 566 ARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSST 625
Query: 774 MDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGV 833
+SE+R + + D + SV+ + + S L +S K ++KG
Sbjct: 626 SSSSESRSRSR--------GRGHNRDRKHRRSVDRKRRDTSGLERSHK-------SSKG- 669
Query: 834 PAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLK 872
+ DT+G + R + +K SIS ++ S K
Sbjct: 670 -GSSRDTKGSKDKNSR--------SDRKRSISESSRSGK 699
Score = 48.1 bits (113), Expect = 6e-05
Identities = 48/224 (21%), Positives = 94/224 (41%), Gaps = 33/224 (14%)
Query: 1137 EQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKS 1196
+QE V + +R +E+E++ ++E E R +V R R R ++ + E+K
Sbjct: 157 KQESTVATERQKRRQEIEQKLEVQAEEE--RKQVENERRELFEER-RAKQTELRLLEQKV 213
Query: 1197 EKKEKAQE--EPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAER---------- 1244
E + +E E AK++ + +TK P ++++P QK E ++R
Sbjct: 214 ELAQLQEEWNEHNAKIIK--YIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRR 271
Query: 1245 -----------AKEREKRRKEQEE-----EEQKEREKEAERERNRQLEREKRREHSRERD 1288
A+ R + KE+E EEQK ++E + + + E +H+
Sbjct: 272 IEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEI 331
Query: 1289 RERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRST 1332
E E E++ D E+++E ++ + K + R +
Sbjct: 332 EEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRES 375
Score = 47.0 bits (110), Expect = 1e-04
Identities = 39/189 (20%), Positives = 84/189 (44%), Gaps = 16/189 (8%)
Query: 1134 EQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKE 1193
EQ+ + ++E+W E ++ + RT+++ R P ++ + +RK A +
Sbjct: 210 EQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEG 269
Query: 1194 KKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
++ E E+ K +A P + + Q+V+ E ++AE+ + + +R+
Sbjct: 270 RRIEFAEQ-------------INKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQRE 316
Query: 1254 EQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERG 1313
E+ EE + E + E+E HS D E+E+E E + + + E + E
Sbjct: 317 EELEETGNQHNDVEIEEAGEEEEKEIAIVHS---DAEKEQEEEEQKQEMEVKMEEETEVR 373
Query: 1314 RERDRRDTK 1322
++D++
Sbjct: 374 ESEKQQDSQ 382
Score = 42.0 bits (97), Expect = 0.004
Identities = 42/166 (25%), Positives = 69/166 (41%), Gaps = 25/166 (15%)
Query: 1131 PRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK 1190
P A+QR+ E AV ER E R+ + E D D + +S + + R R
Sbjct: 72 PPAKQRDLEGAVSRLGGERRTRRESRQESDPE---DDDVKKPALQSSVVATSKERTRRDL 128
Query: 1191 SKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK 1250
+++ ++K K + LL +K K + A ER+K
Sbjct: 129 IQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTV--------------------ATERQK 168
Query: 1251 RRKEQEE--EEQKEREKEAERERNRQLEREKRREHSRERDRERERE 1294
RR+E E+ E Q E E++ R+L E+R + + R E++ E
Sbjct: 169 RRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVE 214
Score = 38.5 bits (88), Expect = 0.044
Identities = 38/150 (25%), Positives = 61/150 (40%), Gaps = 42/150 (28%)
Query: 1143 REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKA 1202
R ++AE+ +ME R R +S +E + VR +++A+ +E K ++E+
Sbjct: 271 RIEFAEQINKMEARPRRQSMKEKEHQVVRN------------EEQKAEQEEGKVAQREEE 318
Query: 1203 QEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKERE------KRRKEQE 1256
EE T +Q E E A +E+E KEQE
Sbjct: 319 LEE------------------------TGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQE 354
Query: 1257 EEEQKEREKEAERERNRQLEREKRREHSRE 1286
EEEQK+ + E E EK+++ E
Sbjct: 355 EEEQKQEMEVKMEEETEVRESEKQQDSQPE 384
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 95.5 bits (236), Expect = 3e-19
Identities = 162/746 (21%), Positives = 275/746 (36%), Gaps = 90/746 (12%)
Query: 128 GEEMSQNSFIKQYLEKQ---QELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLP 184
GEE S+ + ++Q +EL RQR E + RE EE +S +G +
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQS------CKGHETEEF 204
Query: 185 PDFQSSLERPELELSRHSPRKSSSISEEKGD-------------------SDDEKPRKGE 225
PD + R LEL R + E+ D ++EK ++ E
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 226 RRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEE 285
+ R Q +L + + E QE + R+R ++ L+ ++EEE E++EE E+
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 286 EEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQE----VLERGGRFT 341
+E ++ ++ RE + +E +E E+ R + EE E+ R QE+E L R +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 342 RSQEEARKSHLARQQQ---EKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKK 398
R Q+ R+ L R+QQ E++++ L E++ + Q +E+ + + ++R++
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 399 ASLVALPEQTAS----EEET---------PPPLLTKEASSPPPHPQLHSEEEIEPMEGPA 445
L E+ EEET +E +L EE E E
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Query: 446 PPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQ 505
QL + + L + +L L S + E + E +L +
Sbjct: 505 Q----QLRREQEERREQRLKRQEEEERL---QQRLRSEQQLRREQEERR---EQLLKREE 554
Query: 506 KSTLADYSAQKDLEPESDRSAQPLPLKIEE--LALAKGITEECLKQPSLEQKEGRRASHT 563
+ L ++ L+ E + L + EE K EE L+Q L+++E R
Sbjct: 555 EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ-RLKREEVERLEQE 613
Query: 564 LLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQ------A 617
RLK+ R S R + + R K+ + +
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673
Query: 618 RTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSG 677
R H R ++ E + ++R R +S + L S Y+ + G
Sbjct: 674 REHEEERREQEL----AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR-KQEG 728
Query: 678 QEVATPPVPQLQVCEPKERTSTSSSSVQ----ARRLSQPESAEKHVTQRLQPERGSPKKC 733
Q + Q E K R S Q A R Q E + T + Q E S +
Sbjct: 729 QR-------RRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGR 781
Query: 734 EAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPI- 792
+ A PP Q + +R EEKE+ E E E +
Sbjct: 782 QRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQ 841
Query: 793 ----ADQVSNDDRPEGSVEDEEKKES 814
A Q+ ++ +G ED+E++ S
Sbjct: 842 RRERAQQLQEEE--DGLQEDQERRRS 865
Score = 87.8 bits (216), Expect = 6e-17
Identities = 61/236 (25%), Positives = 114/236 (48%), Gaps = 11/236 (4%)
Query: 1102 RPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQ--REQERAVREQWAEREREMERRERT 1159
R E + EQ + R ++ Q R EQ R +++ REQ RE+++ R ++
Sbjct: 366 REQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 425
Query: 1160 RSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTK 1219
R E+E +R + + R + R ++ER +++ E + QE +L D + +
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR 485
Query: 1220 AAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQ---LE 1276
WL L + + +++ R ++ + ++ R+EQ + Q+E E+ +R R+ Q E
Sbjct: 486 ER----WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 1277 REKRREH--SRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSR 1330
+E+RRE RE ++ E+ER R R+++ RD+ RE +RR + R
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Score = 86.3 bits (212), Expect = 2e-16
Identities = 65/256 (25%), Positives = 121/256 (47%), Gaps = 16/256 (6%)
Query: 1086 YAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQ 1145
+ +Q E + R +E K+E +G R L PP Q + RAE+R+Q ++
Sbjct: 755 HRQQQEEEQRRDFTWQWQAEEKSE-RGRQR-LSARPPLREQRERQLRAEERQQRE---QR 809
Query: 1146 WAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEE 1205
+ E E E+R R R ERE + + E + + R R ++ +E ++ E++ ++
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 1206 PPAKLLDDLFRKTK-------AAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEE 1258
K L + K A P + + Q++Q+E E +R + ++RR+EQE +
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQ 929
Query: 1259 EQKEREKEAERERNRQLEREKRREHSRER----DRERERERERDRGDRDRDRERDRERGR 1314
++E + + E E+ + EREKRR RER D++ +++ E+ G+ R R +
Sbjct: 930 YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKK 989
Query: 1315 ERDRRDTKRHSRSRSR 1330
R+ + ++ R
Sbjct: 990 YREEEELQQEEEQLLR 1005
Score = 85.9 bits (211), Expect = 2e-16
Identities = 57/217 (26%), Positives = 113/217 (52%), Gaps = 16/217 (7%)
Query: 1135 QREQERAVREQWAEREREMERRERTRSEREWDRDK-VREGPRSRSRSRDRRRKERAKSKE 1193
+REQE REQ RE+++ R ++ R E++ R++ +R + R + RR ++ + ++
Sbjct: 365 RREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424
Query: 1194 KKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
+ E++E+ E+ + + K + WL ++E ER E+ + +++ ++
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQEERRDWLKR------EEETERHEQERRKQQLKR 478
Query: 1254 EQEEE---------EQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDR 1304
+QEEE E++ RE++ RE+ + E+E+RRE +R E ER ++R R ++
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 1305 DRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
RE++ R + R + KR + R R++ RR
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Score = 83.6 bits (205), Expect = 1e-15
Identities = 141/672 (20%), Positives = 248/672 (36%), Gaps = 94/672 (13%)
Query: 141 LEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSR 200
L K++E L++ + RE E EE + E + + E + Q R E +L R
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE----EQQQQRLRREQQLRR 308
Query: 201 HSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLR 260
+ EE+ + + + ++ ERR ++R+ E+EE +E R +
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRR-------------EQEERREQQLRREQ 355
Query: 261 VRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKE----------------- 303
R + E+EEE E++ E++ E Q RE + +E
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 304 ----------FKEEGEEIPRVKPEEMMDERPKTRSQEQ--EVLERGGRFTRSQEEARKSH 351
+E+ EE K E+ E+ R QE+ + L+R R ++E RK
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQ 475
Query: 352 LARQQQEKEMKTTSPLEEEER---EIKSSQGLKEKSKSPSPPRL----TEDRKKASLVAL 404
L R Q+E+ + LEEEER + + Q L+ + + RL E+R + L +
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 405 PEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTREL 464
+ +EE LL +E +L E + ++ QL + + L
Sbjct: 536 QQLRREQEERREQLLKREEEK-----RLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 465 LVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDR 524
Q E +++ E V L Q+ K EPE +R
Sbjct: 591 KREQE-------------------ERLEQRLKREEVERLEQEERRE--QRLKREEPEEER 629
Query: 525 SAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSS 584
Q L + +E + + E +Q EQ+ R L RLK+ + +
Sbjct: 630 RQQLLKSEEQEERRQQQLRRE--QQERREQRLKREEEEERL-EQRLKREHEEERREQELA 686
Query: 585 SSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSR 644
++R R S + L S + D Q++ ++ PR + R E + R R
Sbjct: 687 EEEQEQARERI-KSRIPKWQWQLES-EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRES 744
Query: 645 S---RSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQE--VATPPVPQLQVCEPKERTST 699
+ R+ RD + + + G++ A PP+ E +ER
Sbjct: 745 ELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR-----EQRERQLR 799
Query: 700 SSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPES 759
+ Q + PE EK +R + ER + EE + + Q + + L E
Sbjct: 800 AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 760 ERIHHTVEEKEE 771
+ + E++ +
Sbjct: 860 QERRRSQEQRRD 871
Score = 82.4 bits (202), Expect = 3e-15
Identities = 60/221 (27%), Positives = 111/221 (50%), Gaps = 10/221 (4%)
Query: 1126 QPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR 1185
+P Q R +++EQER + AE E + E++ER RD+ R + R+ RR
Sbjct: 132 EPGQRRRQKRQEQEREL----AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR 187
Query: 1186 KERAKSKEKKSEKKEKAQEEPPAKL--LDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAE 1243
E + + K + E+ +E + L +L RK + D ++ Q+E E+
Sbjct: 188 AEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQD-RVFQEEEEKEW 246
Query: 1244 RAKE---REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRG 1300
R +E R++ K QEEE Q++RE + E E+ R+LER++ R +E +++++R R +
Sbjct: 247 RKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL 306
Query: 1301 DRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
R ++ ER ++ R++++ + R R++ RR
Sbjct: 307 RRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Score = 82.4 bits (202), Expect = 3e-15
Identities = 52/207 (25%), Positives = 101/207 (48%), Gaps = 12/207 (5%)
Query: 1134 EQREQERAVREQWAEREREMERRERTRSEREWDR--------DKVREGPRSRSRSRDRRR 1185
E+R +++ REQ RE+E R +R + + E +R ++R R +R
Sbjct: 494 EERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKRE 553
Query: 1186 KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERA 1245
+E+ +E++ ++ ++ QEE +LL + + + ++ ++E ER E+
Sbjct: 554 EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613
Query: 1246 KEREKRRKEQEEEEQKERE----KEAERERNRQLEREKRREHSRERDRERERERERDRGD 1301
+ RE+R K +E EE++ ++ +E E R +QL RE++ + RE E ER R
Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673
Query: 1302 RDRDRERDRERGRERDRRDTKRHSRSR 1328
R+ + ER + E ++ + +SR
Sbjct: 674 REHEEERREQELAEEEQEQARERIKSR 700
Score = 82.0 bits (201), Expect = 3e-15
Identities = 58/216 (26%), Positives = 113/216 (52%), Gaps = 19/216 (8%)
Query: 1135 QREQERAVREQWAEREREMERRERTRSEREWDRDKVRE-GPRSRSRSRDRRRKERAKSKE 1193
Q+E+E+ +RE+ E+ R ER + R E E +++ + G +R R ++ K +E
Sbjct: 1027 QQEEEQLLREE-REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE 1085
Query: 1194 KKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
+ E+++ +EEP + + R+ + L + Q++++E E+ R +E E++ +
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEE---ELQQEEEQLLREEREKRRR-QELERQYR 1141
Query: 1254 EQEEEEQKERE---KEAERERNRQLEREKRREHS---------RERDRERERERERD-RG 1300
E+EE +Q+E + +E E+ R ++LER+ R E RE +R +ERER R
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201
Query: 1301 DRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRD 1336
+ + R++ ++R R+ D+R + + VRD
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRD 1237
Score = 80.9 bits (198), Expect = 8e-15
Identities = 65/285 (22%), Positives = 126/285 (44%), Gaps = 67/285 (23%)
Query: 1086 YAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQ 1145
+ E++E ++ + V R E K +E+ R Q E+ EQ R + Q
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQR-------------QRELQEEEEQLRKLERQ 284
Query: 1146 WAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEE 1205
RER+ E +++ R RE + +E R + R ++ER + +E++ E++ + ++E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 1206 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEE-------- 1257
+ + Q E+ E +E++ RR+++EE
Sbjct: 345 -------------------------ERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 1258 ------------EEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRD 1305
E+Q RE++ RE+ + E++ RRE R+++ RE+E +R ++ +
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 1306 RERDRER-GRERDRR--------DTKRHSRSRSRSTPVRDRGGRR 1341
+ER +R RE++ R +T+RH + R + RD+ R
Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Score = 80.5 bits (197), Expect = 1e-14
Identities = 58/251 (23%), Positives = 115/251 (45%), Gaps = 42/251 (16%)
Query: 1126 QPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDK---------------- 1169
Q + R EQR+++R E W +R+ ER ER E + K
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 1170 ----VREGPRSRSRSRDRRRKERAKSKEKKSE----------KKEKAQEEPPAKLLDDLF 1215
+R R + + R R++R +E++ E ++EK QEE P + +
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 1216 RKTKAAPCIYWLPLTDSQIVQKEAERAERAKER-----EKRRKEQEEEEQKEREKEAERE 1270
+ + L + Q +++E + E+ ++R + RRK++EE +++ E+ ++E
Sbjct: 274 EEEQ-------LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 1271 RNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSR 1330
R Q E + ++ RE++ RE++ R++ + R+++ RE+ ER + +R + R
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 1331 STPVRDRGGRR 1341
R++ RR
Sbjct: 387 QQLRREQQLRR 397
Score = 80.5 bits (197), Expect = 1e-14
Identities = 55/210 (26%), Positives = 103/210 (49%), Gaps = 11/210 (5%)
Query: 1134 EQREQERAVREQWAERER----------EMERRERTRSEREWDRDKVREGPRSRSRSRDR 1183
E+REQE A EQ RER ++E R + + R + +EG R R ++
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Query: 1184 RRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAE 1243
RR+ ++ + ++ E+ + Q+E + + + L+ ++++ ER
Sbjct: 739 RRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 1244 RAKEREKRRKE-QEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDR 1302
RA+ER++R + EEE+KE+ + RER ++L+ + E + R+R ++ + E D
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 1303 DRDRERDRERGRERDRRDTKRHSRSRSRST 1332
D++R R +E+ R++ R R R R T
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Score = 76.3 bits (186), Expect = 2e-13
Identities = 59/228 (25%), Positives = 112/228 (49%), Gaps = 18/228 (7%)
Query: 1117 LHPPPPPPVQPPQHPRAEQREQERAVREQWAERER-EMERRERTRSEREWDRDKVREGPR 1175
L+ P Q + + Q E+E RE+ +R R E ER+ R + + + +++ R
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948
Query: 1176 SRSRSRDRRRKERAKSKEKKSEKKEKAQ--EEPPAKLLDDLFRKTKAAPCIYWLPLTDSQ 1233
+ R ++R R+ R K+KK ++KE+ EEP + + +K + + +
Sbjct: 949 EKRRRQERERQYR---KDKKLQQKEEQLLGEEPEKRRRQEREKKYR-----------EEE 994
Query: 1234 IVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERER 1293
+Q+E E+ R + ++RR+E E + +K+ E + E E+ + EREKRR RER E
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEE 1054
Query: 1294 ERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
E +++ ++ ER+ R +E +R+ K + +R+ +R
Sbjct: 1055 ELQQEE-EQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Score = 75.9 bits (185), Expect = 2e-13
Identities = 60/230 (26%), Positives = 115/230 (50%), Gaps = 35/230 (15%)
Query: 1126 QPPQHPRAEQREQERAVREQWAEREREMERRERTRSER-EWDRDKVREGPRSRSRS---R 1181
+ P+ R ++RE++ E+ + E ++ R ER + R EW+R ++ + R
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 1182 DRRRKERAKSKEKKSEKKEKAQEEPPAKL-----------LDDLFRKTKAAPCIYWLPLT 1230
+ R K R + +E++ ++E+ Q+E L L+ +RK + L
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEE------LQQE 1089
Query: 1231 DSQIVQKEAERAERAKEREKRRKEQEEEEQKERE----KEAERERNRQLEREKRREHSRE 1286
+ Q++++E E+ R +ERE++ +E EEE Q+E E +E E+ R ++LER+ R E +
Sbjct: 1090 EEQLLREEPEKRRR-QERERQCRE-EEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 1287 RDRE---RERERERDRGDRDRDRERDRERGRE-----RDRRDTKRHSRSR 1328
++ E RE +R R + +R + E +E R+ ++ +R R R
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Score = 75.9 bits (185), Expect = 2e-13
Identities = 55/200 (27%), Positives = 108/200 (54%), Gaps = 23/200 (11%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKS 1191
R Q++ + + EQ ER+RE ERR + +R + ++ E R ++ +R++R KS
Sbjct: 1261 RQSQQDLQHLLGEQ-QERDREQERRRWQQRDRHFPEEEQLE----REEQKEAKRRDR-KS 1314
Query: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
+E+K +E+ +E+ + D FR+ + Q++Q+ E+ R +ER+++
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFRE-------------EEQLLQEREEQPLRRQERDRK 1361
Query: 1252 RKEQEEEEQKEREK---EAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRER 1308
+E+E Q++ K E +R R ++ ER+ +E + R +ERE++ +DR + R+ E+
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421
Query: 1309 DRERGRERDRRDTKRHSRSR 1328
R +ERDR+ + + R
Sbjct: 1422 QLSR-QERDRKFREEEQQVR 1440
Score = 75.9 bits (185), Expect = 2e-13
Identities = 59/224 (26%), Positives = 113/224 (50%), Gaps = 27/224 (12%)
Query: 1126 QPPQHPRAEQREQERAV-REQWAERER------EMERRERTRSEREWDRDKVREGPRSRS 1178
Q QH EQ+E++R R +W +R+R ++ER E+ ++R DR E R
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRR-DRKSQEEKQLLRE 1323
Query: 1179 RSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLL--DDLFRKTKAAPCIYWLPLTDSQIVQ 1236
++RR++ K ++ E+ + +EE P + D FR+ + L + +
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE---------LRHQEQGR 1374
Query: 1237 KEAERAERAKEREKRRKEQEEEEQ---KEREKEAERERNRQLEREKRREHSRERDRERER 1293
K E +R + +E+ RK +EE+Q +ERE++ ++R+R+ E+++ +ERDR+
Sbjct: 1375 KFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE 1434
Query: 1294 ERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
E ++ R +ER+R+ E + +RH + R +++R
Sbjct: 1435 EEQQVRR-----QERERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Score = 75.5 bits (184), Expect = 3e-13
Identities = 57/226 (25%), Positives = 107/226 (47%), Gaps = 25/226 (11%)
Query: 1126 QPPQHPRAEQR-EQERAVREQWAEREREMERRERTRSEREWDRDKVREG--------PRS 1176
Q + R EQR ++E+ R W +RE E ER E+ R +++ RD+ E
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 1177 RSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLL----DDLFRKTKAAPCIYWLPLTDS 1232
R ++RR ++ + +E++ E++ K QEE + R+ + L +
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 1233 QIVQKEAERAERAKEREKRRKE---QEEEEQKEREKEAERERNRQ---------LEREKR 1280
+ +++E +E+E+RR + +EEE +++R K + ER Q LE+E+R
Sbjct: 556 KRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 1281 REHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSR 1326
RE +R+ E R++ +++ R ++ RE+ R +R R
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Score = 74.7 bits (182), Expect = 6e-13
Identities = 142/739 (19%), Positives = 270/739 (36%), Gaps = 87/739 (11%)
Query: 122 QPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASA-----ESEDEMIHP 176
+P Q G+ Q K+ ++ EL Q ER R+ E E+ ++E++
Sbjct: 722 RPRKQEGQRRRQEQEEKRR-RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 177 EGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARA 236
S PP + ER R + EE+ + + R+ E+ + +
Sbjct: 781 RQRLSARPP-LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 237 AKLSEGSQPAEEEED----QETPSRNLRVRADRNLKTEEEEE------------------ 274
+ E +Q +EEED + R+ R D+ + + EEE
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL 899
Query: 275 -EEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEV 333
+E++ +++EEE +E +K R ++++EE E++ + + + + +ER K R QE+E
Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREE-EQLQQEEEQLLREEREKRRRQERER 958
Query: 334 LERGGRFTRSQEE----ARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSP 389
R + + +EE RQ++EK+ + L++EE ++ + +EK +
Sbjct: 959 QYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE--REKRRRQEW 1016
Query: 390 PRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVL 449
R + RKK L EQ EE L +E Q EEE++ E
Sbjct: 1017 ER--QYRKKDELQQEEEQLLREEREKRRLQERER-------QYREEEELQQEEE------ 1061
Query: 450 IQLSPPNTDADTRELLVSQH----TVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQ 505
QL + R+ L Q+ +Q P + + + EE L +
Sbjct: 1062 -QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120
Query: 506 KSTLAD-------------YSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSL 552
+ L + Y +++++ E ++ + P K L + EE L
Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE----EEL 1176
Query: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQR 612
+Q+E + + +Q + + R R D K+
Sbjct: 1177 QQEEEQLLRE---EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 613 DVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETK 672
V + + +GR R +S+ R R S++ L + + +
Sbjct: 1234 AVRDNKVYC--KGRENEQFRQLEDSQLRDR--------QSQQDLQHLLGEQQERDREQER 1283
Query: 673 DPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKK 732
++ P QL+ E KE S + ++L + E EK Q + ++
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 733 CEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPI 792
E E P Q + + + L E+ +EE++ + E + + +
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403
Query: 793 ADQVSNDDRPEGSVEDEEK 811
+Q DR E+E++
Sbjct: 1404 REQQLRQDRDRKFREEEQQ 1422
Score = 74.3 bits (181), Expect = 7e-13
Identities = 66/261 (25%), Positives = 122/261 (46%), Gaps = 19/261 (7%)
Query: 1082 LCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERA 1141
L A A Q++L + LL + E + EE+ R Q + RE+E+
Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRR------------QEQERQYREEEQL 936
Query: 1142 VREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
+E+ E E+R R ER++ +DK + + + K R + +EKK ++E+
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQ-QKEEQLLGEEPEKRRRQEREKKYREEEE 995
Query: 1202 AQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRR-KEQEEEEQ 1260
Q+E L ++ ++ + + +Q+E E+ R +EREKRR +E+E + +
Sbjct: 996 LQQEEEQLLREEREKRRRQE---WERQYRKKDELQQEEEQLLR-EEREKRRLQERERQYR 1051
Query: 1261 KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD 1320
+E E + E E+ ERE RR ER +E E +++ R+ E ++ R +ER+R+
Sbjct: 1052 EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE-EPEKRRRQERERQC 1110
Query: 1321 TKRHSRSRSRSTPVRDRGGRR 1341
+ + +R+ +R
Sbjct: 1111 REEEELQQEEEQLLREEREKR 1131
Score = 74.3 bits (181), Expect = 7e-13
Identities = 56/216 (25%), Positives = 110/216 (50%), Gaps = 24/216 (11%)
Query: 1135 QREQERAVREQWAERER-EMERRERTRSEREWDRDKV-REGPRSRSRSRDR--------- 1183
Q+E+E+ +RE+ +R R E+ER+ R E + + +++ RE R + R+R
Sbjct: 1147 QQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 1184 --RRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEA-- 1239
+RK+R + ++++S+ K + + E + D+ K + L DSQ+ +++
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY-CKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 1240 -------ERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERE 1292
E+ ER +E+E+RR +Q + E E++ ERE ++ +R R+ ++ E
Sbjct: 1266 DLQHLLGEQQERDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Query: 1293 RERERDRGDRDRDRERDRERGRERDRRDTKRHSRSR 1328
RE +R R + DR + + +ER+ + +R R R
Sbjct: 1325 REEKRRRQETDRKFREEEQLLQEREEQPLRRQERDR 1360
Score = 72.4 bits (176), Expect = 3e-12
Identities = 61/250 (24%), Positives = 120/250 (48%), Gaps = 39/250 (15%)
Query: 1088 EQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWA 1147
E++E HR +R + EEQ + R Q EQ + + ++
Sbjct: 1472 EREEQQLHRQ---ERDRKFLEEEQQLRR----------QERDRKFREQELRSQEPERKFL 1518
Query: 1148 EREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPP 1207
E E+++ R++R R + + ++R R + R +DR RK R E++ ++E+ +++
Sbjct: 1519 EEEQQLHRQQRQRKFLQ-EEQQLRRQERGQQRRQDRDRKFR----EEEQLRQEREEQQLS 1573
Query: 1208 AKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEA 1267
+ D FR L + ++ ++E ER E++ RR+E +++ ++ER+++
Sbjct: 1574 RQERDRKFR------------LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 1268 ERERNRQLEREKRREHSRERDRE--------RERERERD-RGDRDRDRERDRERGRERDR 1318
+ ERE+++ H +ERDR+ R +ERE+ R DRDR + + +E +
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 1319 RDTKRHSRSR 1328
+ +R R R
Sbjct: 1682 QQLRRQERDR 1691
Score = 72.0 bits (175), Expect = 4e-12
Identities = 62/251 (24%), Positives = 127/251 (50%), Gaps = 39/251 (15%)
Query: 1101 DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAER----EREMERR 1156
DR + + EEQ + R Q + RE+E+ VR Q ER E + R+
Sbjct: 1411 DRDRKFREEEQQLSR-------------QERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Query: 1157 ERTRSEREWDRD-KVREGPRSRSRSRDRRRKE-----RAKSKEKKSEKKEKAQEEPPAKL 1210
ER R RE ++ + RE + + RDR+ E R + +++K ++E +EP K
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517
Query: 1211 LDD---LFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEE-EEQKEREKE 1266
L++ L R+ + L + Q ++++ +R ++R+++ +E+E+ +++E ++
Sbjct: 1518 LEEEQQLHRQQRQRKF-----LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Query: 1267 AERERNRQLEREKRREHSRERDR---ERERERERDRGDRDRDRERDRERGRE----RDRR 1319
+ +ER+R+ E+++ +E++R E E++ R G + +ERDR+ + ++R
Sbjct: 1573 SRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE 1632
Query: 1320 DTKRHSRSRSR 1330
+ + H + R R
Sbjct: 1633 EQQLHRQERDR 1643
Score = 71.6 bits (174), Expect = 5e-12
Identities = 79/322 (24%), Positives = 137/322 (42%), Gaps = 51/322 (15%)
Query: 109 ENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQ-----YLEKQQELLRQRLEREAREAAELE 163
E Q H F+ Q+ +E + +Q +LE++Q+L RQ +R+ RE E
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ---E 1507
Query: 164 EASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRK 223
S E E + + E L R + R+ + EE ++ R+
Sbjct: 1508 LRSQEPERKFLEEE-----------QQLHRQQ--------RQRKFLQEE------QQLRR 1542
Query: 224 GERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEE-- 281
ER R RQ R K E Q +E E+Q+ R DR + EE++ +E+E
Sbjct: 1543 QERGQQR-RQDRDRKFREEEQLRQEREEQQLS----RQERDRKFRLEEQKVRRQEQERKF 1597
Query: 282 -DDEEEEGDDEGQ---------KSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQ 331
+DE++ EGQ K RE L + +EE + + + + ++E P+ R QE+
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657
Query: 332 EVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPR 391
E R R + +EE + +QQ + + EEE++++ + ++ + R
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 392 LTE-DRKKASLVALPEQTASEE 412
E +RK L ++T E+
Sbjct: 1718 RQELERKFREEEQLRQETEQEQ 1739
Score = 70.1 bits (170), Expect = 1e-11
Identities = 50/222 (22%), Positives = 101/222 (45%), Gaps = 30/222 (13%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSR-SRSRDRRRKE 1187
+ P E+R+Q EQ R++++ R ++ R E+ R++ E R R + R+E
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKE 1247
+ ++E++ + +E+ + P W +S+ ++++ R ++
Sbjct: 683 QELAEEEQEQARERIKSRIPK-----------------WQWQLESEADARQSKVYSRPRK 725
Query: 1248 REKRRKEQEEEEQKERE------KEAERERNRQLEREKRREHSRERDRERERERERDRGD 1301
+E +R+ QE+EE++ R +E ER +Q E E+RR+ + + E + ER R R
Sbjct: 726 QEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785
Query: 1302 ------RDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
R+R+ E ++R++R R R+R
Sbjct: 786 ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Score = 69.3 bits (168), Expect = 2e-11
Identities = 75/305 (24%), Positives = 134/305 (43%), Gaps = 71/305 (23%)
Query: 1086 YAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAE--QREQERAVR 1143
Y E++EL L+ ET+ ++ Q+ + E Q+E+E+ +R
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQE--------------LERQYRKEEELQQEEEQLLR 1095
Query: 1144 EQWAERER-EMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKA 1202
E+ +R R E ER+ R E + + +++ R + R ++ R+ R + +E + E+++
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR-EEEEVQQEEEQLL 1154
Query: 1203 QEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKERE----------KRR 1252
+EEP + +L R+ + L + Q++++E E+ + +ER+ KR+
Sbjct: 1155 REEPEKRRRQELERQYREEE---ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 1253 KEQEEEEQK-------EREKE------------AERERNRQLEREKRREHS--------- 1284
+ +E+Q+ E EKE E E+ RQLE + R+
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 1285 ---RERDRERERERERDRGDRDRDRER-DRERGRERDRRDTK--------RHSRSRSRST 1332
+ERDRE+ER R + R + E+ +RE +E RRD K R R R
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 1333 PVRDR 1337
DR
Sbjct: 1332 QETDR 1336
Score = 69.3 bits (168), Expect = 2e-11
Identities = 60/204 (29%), Positives = 109/204 (53%), Gaps = 14/204 (6%)
Query: 1137 EQERAVREQWAEREREMERRERTRSEREW----DRD-KVREGPRSRSRSRDRRRKERAKS 1191
E+E+ +R Q ER+ E ++ ERE DRD K RE + SR ++R RK R +
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR-QERDRKFREEE 1436
Query: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
++ + +++E+ E +L + RK + + + Q+ ++E +R +E++ R
Sbjct: 1437 QQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ-EREEQQLHRQERDRKFLEEEQQLR 1495
Query: 1252 RKEQEEE--EQKEREKEAER---ERNRQLEREKR-REHSRERDRERERER-ERDRGDRDR 1304
R+E++ + EQ+ R +E ER E +QL R++R R+ +E + R +ER ++ R DRDR
Sbjct: 1496 RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 1305 DRERDRERGRERDRRDTKRHSRSR 1328
+ + +ER+ + R R R
Sbjct: 1556 KFREEEQLRQEREEQQLSRQERDR 1579
Score = 68.6 bits (166), Expect = 4e-11
Identities = 78/366 (21%), Positives = 155/366 (42%), Gaps = 22/366 (6%)
Query: 85 EQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQ 144
E++ L + +K +R K E LQ+ + + +E + K L+++
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 145 QE-LLRQRLER---EAREAAELEEASAESEDEMIHPEGVASLLPPDFQ------SSLERP 194
+E LLR+ E+ + RE EE + E+E + E + + + L++
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQE 1089
Query: 195 ELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQET 254
E +L R P K E+ ++E+ ++ E + R + + + Q EEEE Q+
Sbjct: 1090 EEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE 1149
Query: 255 PSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRV 314
+ LR ++ + E E + EEEE EEE+ E Q+ R ++++EE EE+ R
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE-EELQRQ 1208
Query: 315 KPEEMM---DERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEE 371
K ++ D+R + Q + E R + + R++ RQ ++ +++ + +
Sbjct: 1209 KRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD----RQSQ 1264
Query: 372 REIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQ 431
++++ G +++ R + R + PE+ E E ++ S
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDR----HFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 432 LHSEEE 437
L E E
Sbjct: 1321 LREERE 1326
Score = 68.2 bits (165), Expect = 5e-11
Identities = 62/255 (24%), Positives = 118/255 (46%), Gaps = 16/255 (6%)
Query: 1086 YAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQ 1145
Y E++E+ L+ R K Q + R + Q R EQ E+ R RE+
Sbjct: 1140 YREEEEVQQEEEQLL-REEPEKRRRQELERQYREEEELQQEEEQLLREEQ-EKRRQERER 1197
Query: 1146 WAEREREMERRERTRSEREWDRD---KVREGPRSRSRSRDRRRKERAKSKEK-----KSE 1197
E E++R++R + R+ D+ K + P + RD + + + E+ S+
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQ 1257
Query: 1198 KKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEE 1257
+++ ++ LL + + + W D ++E E KE ++R ++ +E
Sbjct: 1258 LRDRQSQQDLQHLLGEQQERDREQERRRWQQ-RDRHFPEEEQLEREEQKEAKRRDRKSQE 1316
Query: 1258 EEQKEREKEAERERNRQLEREKRREHS--RERDRERERERERDRGDRDRDRERDRERGRE 1315
E+Q RE+ E+ R ++ +R+ R E +ER+ + R +ERDR R+ + R +E+GR+
Sbjct: 1317 EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL-RHQEQGRK 1375
Query: 1316 --RDRRDTKRHSRSR 1328
+ + +R R R
Sbjct: 1376 FLEEEQRLRRQERER 1390
Score = 67.8 bits (164), Expect = 7e-11
Identities = 71/305 (23%), Positives = 130/305 (42%), Gaps = 38/305 (12%)
Query: 162 LEEASAESEDEMIHPEGVASLLPPDFQSSLERP------ELELSRHSPRKSSSISEEKGD 215
L +A+ E++ +G SLL Q +R +LE R+ +E+
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148
Query: 216 SD-DEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNL--------------- 259
++ +E+ K ER R RQ R +L Q +E E++ L
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 260 ----RVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVK 315
R + K EE++++ E +D +E +++ + RE + KE ++ EE P+ +
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ-R 267
Query: 316 PEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQ--EKEMKTTSPLEEEERE 373
E+ +E + R E++ L R R +EE ++ L R+QQ K+ + +EE RE
Sbjct: 268 QRELQEEEEQLRKLERQELRR----ERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 374 IKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLH 433
+ + +E+ + R E+R++ L + EEE L +E QL
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQL-----RREQEEERREQQLRREQEEERREQQLR 378
Query: 434 SEEEI 438
E+++
Sbjct: 379 REQQL 383
Score = 67.4 bits (163), Expect = 9e-11
Identities = 72/249 (28%), Positives = 121/249 (48%), Gaps = 36/249 (14%)
Query: 1101 DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTR 1160
DR E + +Q R H P + Q R EQ+E +R R+ E++ E RE R
Sbjct: 1278 DREQERRRWQQ---RDRHFP-----EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKR 1329
Query: 1161 SEREWDRDKVREGPRSRSRSRDR--RRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKT 1218
+E DR K RE + ++ RR+ER ++K ++E +E K L++ R
Sbjct: 1330 RRQETDR-KFREEEQLLQEREEQPLRRQER----DRKFREEELRHQEQGRKFLEEEQRLR 1384
Query: 1219 KAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQE-------------EEEQKEREK 1265
+ +L + Q+ +E E+ R ++R+++ +E+E EEEQ+ R +
Sbjct: 1385 RQERERKFLK-EEQQLRCQEREQQLR-QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ 1442
Query: 1266 EAER---ERNRQLEREKRREHSRERDRERERERER-DRGDRDRD--RERDRERGRERDRR 1319
E ER E +QL +E+ R+ E +ERE ++ R +RDR E + R +ERDR+
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 1320 DTKRHSRSR 1328
++ RS+
Sbjct: 1503 FREQELRSQ 1511
Score = 66.6 bits (161), Expect = 2e-10
Identities = 79/363 (21%), Positives = 153/363 (42%), Gaps = 51/363 (14%)
Query: 57 RKMAELEEVTLDGKPLQALRVT-DLKAALEQRGLAKSGQKSALVKRLKGALMLENLQK-H 114
RK E E++ + + Q R D K LE++ + + Q+ ++ + E Q+
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 115 STPHAAFQPNSQIGEEMSQNSFIKQ-----YLEKQQELLRQRLEREAREAAELEEASAES 169
F+ + Q+ +E + +Q +LE++ +L RQ E++ R + +
Sbjct: 1615 QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR---- 1670
Query: 170 EDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEE---------KGDSDDEK 220
E+E + EG L + R E + R R+ + EE + ++E+
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Query: 221 PRKGERRSSRVRQARAAKLSEGSQ--PAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEE 278
R+ + RQ R K+ E Q P EE+ R+ + R + L+ +E EE++
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR-QEREEQQLR 1789
Query: 279 EEEDDEEEEGDDEGQKSREAPILKEFKEEG--------------------EEIPRVKPEE 318
+E D + +++ ++ RE L+ + +G E + + EE
Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEE 1849
Query: 319 MMDERPKTRSQEQEVLERGGRFTRSQEE--ARKSHLARQQQEKEMKTTSPLEEEEREIKS 376
+ K+R +EQE+ + + R + E R+ H+ RQQ+E++ + EIKS
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR------HRQVGEIKS 1903
Query: 377 SQG 379
+G
Sbjct: 1904 QEG 1906
Score = 65.1 bits (157), Expect = 4e-10
Identities = 61/259 (23%), Positives = 118/259 (45%), Gaps = 34/259 (13%)
Query: 1088 EQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQR---EQERAVRE 1144
E+ E + + LL E + ++Q ++ Q R EQR E+E E
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQ-------------LRREQQERREQRLKREEEEERLE 669
Query: 1145 QWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQE 1204
Q +RE E ERRE+ +E E +++ RE +SR + + A +++ K + + QE
Sbjct: 670 QRLKREHEEERREQELAEEE--QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Query: 1205 EPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKERE 1264
+ + R+ + +S++ +E ERA R ++ E++R++ + Q E +
Sbjct: 728 GQRRRQEQEEKRRRR-----------ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 1265 KEAERER--NRQLEREKRREHSRERDRERERER---ERDRGDRDRDRERDRERGRERDRR 1319
E R+R R RE+R R +R++ +R E + ++ R + R+RE+ +
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 1320 DTKRHSRSRSRSTPVRDRG 1338
+ + R R++ + G
Sbjct: 837 EEQLQRRERAQQLQEEEDG 855
Score = 64.3 bits (155), Expect = 7e-10
Identities = 49/210 (23%), Positives = 104/210 (49%), Gaps = 12/210 (5%)
Query: 1126 QPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR 1185
+ PQ R E+ +Q R R++ E ++ + + R +RD+ + R ++R R
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Query: 1186 K---ERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERA 1242
K E + + ++ E+K + +E+ + + R+ + Y L + Q+ ER
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER----YRKILEEEQL---RPERE 1760
Query: 1243 ERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHS--RERDRERERERERDRG 1300
E+ R++R ++ EEEQ +E+E ++ R+++ +R+ R E +ER+ ++ R ++RD
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820
Query: 1301 DRDRDRERDRERGRERDRRDTKRHSRSRSR 1330
R + + E +R R++ R R+ +
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Score = 61.6 bits (148), Expect = 5e-09
Identities = 59/268 (22%), Positives = 120/268 (44%), Gaps = 18/268 (6%)
Query: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201
+++++LLR+ ERE + + + E++++ L + EL RH
Sbjct: 1315 QEEKQLLRE--EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL---RH 1369
Query: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVR-QARAAKLSEGSQPAEEEEDQETPSRNLR 260
+ + EE+ E+ RK + ++R Q R +L + EE+Q+ R
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLS----R 1425
Query: 261 VRADRNLKTEEEEEEEEEEEE---DDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPE 317
DR + EE++ +E E ++E++ + +K RE L + +EE + + +
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 318 EMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSS 377
+ ++E + R QE++ R RSQE RK QQ ++ + L+EE++ +
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQEL-RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544
Query: 378 QGLKEKS----KSPSPPRLTEDRKKASL 401
+G + + K +L ++R++ L
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQL 1572
Score = 61.6 bits (148), Expect = 5e-09
Identities = 43/215 (20%), Positives = 105/215 (48%), Gaps = 33/215 (15%)
Query: 1129 QHPRAEQREQERAVREQWAER-----EREMERRERTRSEREWDRD-KVREGPRSRSRSRD 1182
Q P + E+E+ + Q +R E+++ R+ER + R+ DRD K RE + R +
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ-DRDRKFREEEQLRQEREE 1569
Query: 1183 RRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERA 1242
++ + + ++ + E+++ ++E K ++D + Q+ ++E ++
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFMED-----------------EQQLRRQEGQQQ 1612
Query: 1243 ERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERER----- 1297
R + K R++++ +++E ++ +ER+R+ E+ + +ER+++ +R+R
Sbjct: 1613 LRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 1298 ----DRGDRDRDRERDRERGRERDRRDTKRHSRSR 1328
G+ + R ++R+R + + +R R R
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707
Score = 61.2 bits (147), Expect = 6e-09
Identities = 59/267 (22%), Positives = 118/267 (44%), Gaps = 27/267 (10%)
Query: 138 KQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELE 197
+++LE++Q+L RQ R+ RE +L + E E++ +H + + E +
Sbjct: 1446 RKFLEEEQQL-RQERHRKFREEEQLLQ---EREEQQLHRQ--------ERDRKFLEEEQQ 1493
Query: 198 LSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSR 257
L R + E + + K + E++ R ++ R E +E Q R
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 258 NLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPE 317
+ + R + L+ E EE++ +E D + E QK R ++F E+ +++ R + +
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRL---EEQKVRRQEQERKFMEDEQQLRRQEGQ 1610
Query: 318 EMM--DERPKTRSQEQEVLERGGRFTRSQEEARK-----SHLARQQQEKEMKTTSPLEEE 370
+ + + K R EQ + ER + QE RK L RQ++E++++ +
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR-----HDR 1665
Query: 371 EREIKSSQGLKEKSKSPSPPRLTEDRK 397
+R+ + + L ++ + R DRK
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRK 1692
Score = 61.2 bits (147), Expect = 6e-09
Identities = 56/235 (23%), Positives = 114/235 (48%), Gaps = 25/235 (10%)
Query: 1126 QPPQHPRAEQ-REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRR 1184
Q +H R + RE+E+ ++E E+++ R+ER R RE + ++R R R ++ +
Sbjct: 1659 QQLRHDRDRKFREEEQLLQEG---EEQQLRRQERDRKFRE-EEQQLRRQERERKFLQEEQ 1714
Query: 1185 RKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAER 1244
+ R + E+K ++E+ ++E + L R K P + Q ++++ ER +
Sbjct: 1715 QLRR-QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQ-ERDRK 1772
Query: 1245 AKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDR-----------ERER 1293
+E E+ R+E+EE++ + +E + + QL +E+ + R + R + E
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE 1832
Query: 1294 ERERDRGDRDRD-RERDRERGRERDRRD------TKRHSRSRSRSTPVRDRGGRR 1341
+ +R R +RDR R ++ +E+ RR+ + R + R +R+ RR
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR 1887
Score = 60.8 bits (146), Expect = 8e-09
Identities = 55/199 (27%), Positives = 99/199 (49%), Gaps = 34/199 (17%)
Query: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKK 1195
RE+E+ +E E+ R ER + E + + RE + R + RDR+ +E + ++++
Sbjct: 1726 REEEQLRQETEQEQLRRQERYRKILEEEQLRPE--REEQQLRRQERDRKFREEEQLRQER 1783
Query: 1196 SEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQ 1255
E++ ++QE D FR+ + Q+ Q+ E+ R ++R+ K +
Sbjct: 1784 EEQQLRSQES------DRKFRE-------------EEQLRQEREEQQLRPQQRDG--KYR 1822
Query: 1256 EEEEQKEREKEAER---ERNRQLEREKR---REHSRERDRERERERERDRGDRDRDRERD 1309
EEEQ + E++ +R ER+RQ E++ +E SR ++E +E E + R +ER+
Sbjct: 1823 WEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEE-----QKRRQERE 1877
Query: 1310 RERGRERDRRDTKRHSRSR 1328
R+ E RR K R R
Sbjct: 1878 RKLREEHIRRQQKEEQRHR 1896
Score = 60.5 bits (145), Expect = 1e-08
Identities = 81/378 (21%), Positives = 147/378 (38%), Gaps = 56/378 (14%)
Query: 85 EQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQ 144
EQ+ + +KS K+L E ++ T F+ Q+ +E + +Q +++
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK-FREEEQLLQEREEQPLRRQERDRK 1361
Query: 145 --------QELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPEL 196
QE R+ LE E R + E E++ + + L D E
Sbjct: 1362 FREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQ 1421
Query: 197 ELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQ---- 252
+LSR R EE+ E+ RK ++RQ R K E Q +E E+Q
Sbjct: 1422 QLSRQE-RDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 253 --------ETPSRNLRVRADRNLKTEE-----------EEEEE-----------EEEEED 282
E + R DR + +E EEE++ +EE++
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540
Query: 283 DEEEEGD----DEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGG 338
+E G D +K RE L++ +EE + + + + E K R QEQE
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE-----R 1595
Query: 339 RFTRSQEEARK---SHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTED 395
+F +++ R+ RQ+++++ + L +E E + + +++ P+L
Sbjct: 1596 KFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQ 1655
Query: 396 RKKASLVALPEQTASEEE 413
++ L ++ EEE
Sbjct: 1656 EREQQLRHDRDRKFREEE 1673
Score = 57.4 bits (137), Expect = 9e-08
Identities = 77/333 (23%), Positives = 131/333 (39%), Gaps = 66/333 (19%)
Query: 129 EEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASL------ 182
EE + +Q L +Q+ + RLE + E E E E ++ EG L
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 183 -LPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSE 241
D Q ER E +L R ++ ++E + + R ++R R K E
Sbjct: 1620 KFREDEQLLQEREEQQLHRQE--------RDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 242 GSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPIL 301
Q +E E+Q+ R DR + EE++ +E E +EE Q+ R +
Sbjct: 1672 EEQLLQEGEEQQLR----RQERDRKFREEEQQLRRQERERKFLQEE-----QQLRRQELE 1722
Query: 302 KEFKEEG--------EEIPR-------VKPEEMMDERP-----------KTRSQEQEVLE 335
++F+EE E++ R ++ E++ ER K R +EQ E
Sbjct: 1723 RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Query: 336 RGGRFTRSQEEARKSHLARQ-QQEKEMKTTSP---------------LEEEEREIKSSQG 379
R + RSQE RK Q +QE+E + P LEE+E+ ++ +
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Query: 380 LKEKSKSPSPPRLTEDRKKASLVALPEQTASEE 412
+ +++ + R++ L EQ +E
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEEQKRRQE 1875
Score = 56.6 bits (135), Expect = 2e-07
Identities = 51/232 (21%), Positives = 94/232 (40%), Gaps = 43/232 (18%)
Query: 1123 PPVQPPQHPRAEQREQERAVRE--QWAEREREMERRERTRSEREWDRDKVREGPRSRSRS 1180
P Q Q R EQ E+ R QW E ER +++ R++ E R R
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 1181 RDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAE 1240
R R + +E++ +E+ Q E +LP + + Q+ +
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQR------------------FLP-EEEEKEQRRRQ 823
Query: 1241 RAERAKE----------REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRE 1290
R ER KE + + R +Q +EE+ +++ ER R+++ R+++ E +R+
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883
Query: 1291 RERE------------RERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSR 1330
R R R+ + ++ + E RE +R R++ +R R +
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935
Score = 50.8 bits (120), Expect = 9e-06
Identities = 56/282 (19%), Positives = 121/282 (42%), Gaps = 14/282 (4%)
Query: 138 KQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELE 197
+Q+ + + LR R ++ + E+ + E E + P + Q LER E +
Sbjct: 1248 EQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ--LEREEQK 1305
Query: 198 LSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSR 257
++ RKS + + +EK R+ E + + + E +E D++
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREE 1365
Query: 258 NLRVRADRNLKTEEEEEEEEEEEE----DDEEEEGDDEGQKSREAPILKEFKEEGEEIPR 313
LR + EEE+ +E E +E++ E ++ ++F+EE +++ R
Sbjct: 1366 ELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSR 1425
Query: 314 VKPEEMMDERPKTRSQEQEV--LERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEE 371
+ + K R +EQ+V ER +F +++ R+ + ++E+++ ++
Sbjct: 1426 QERDR------KFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 372 REIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEE 413
R+ + + L+E+ + R + R++ PE+ EEE
Sbjct: 1480 RQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE 1521
Score = 47.8 bits (112), Expect = 7e-05
Identities = 33/112 (29%), Positives = 54/112 (48%), Gaps = 7/112 (6%)
Query: 1214 LFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNR 1273
LF A C Y L +K A + + RR+E+++ + R+++ E E
Sbjct: 76 LFIFKVAQACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPG- 134
Query: 1274 QLEREKRREHSR------ERDRERERERERDRGDRDRDRERDRERGRERDRR 1319
Q R+KR+E R E+ ++ER +RDR RD + R R+ +ER+ R
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER 186
Score = 47.8 bits (112), Expect = 7e-05
Identities = 54/253 (21%), Positives = 100/253 (39%), Gaps = 25/253 (9%)
Query: 57 RKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHST 116
RK E E++ +G+ Q L+ R + Q+ +R + L E +
Sbjct: 1667 RKFREEEQLLQEGEEQQ------LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQE 1720
Query: 117 PHAAFQPNSQIGEEMSQNSFIKQ-----YLEKQQ--------ELLRQRLEREAREAAELE 163
F+ Q+ +E Q +Q LE++Q +L RQ +R+ RE +L
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR 1780
Query: 164 EASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRK 223
+ E E++ + + + Q ER E +L EE+ ++++ R
Sbjct: 1781 Q---EREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR- 1836
Query: 224 GERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDD 283
R R RQ RA + + + EE + + R +R K EE +++EE
Sbjct: 1837 --LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
Query: 284 EEEEGDDEGQKSR 296
+ G+ + Q+ +
Sbjct: 1895 HRQVGEIKSQEGK 1907
Score = 46.6 bits (109), Expect = 2e-04
Identities = 24/96 (25%), Positives = 48/96 (50%)
Query: 1237 KEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296
KE+ +R +E ++RR E + + +E + R++ ++ ERE + +ER +R+
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 1297 RDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRST 1332
R R D + R+R + RE R + ++ + T
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/166 (25%), Positives = 76/166 (45%), Gaps = 25/166 (15%)
Query: 1186 KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERA 1245
++RA+ K+S +++ QEE + + R+ + P + QK E+
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRF-EPRDRQLEEEP--------GQRRRQKRQEQEREL 148
Query: 1246 KEREKRRKEQEEEEQKEREKEAE---RERNRQLEREKRRE----------HSRERDRERE 1292
E E++ ++QE EQ++R++ E R+R ERE+RR H E + E
Sbjct: 149 AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 1293 RERERDRGD-RDRDRERDRERGRERDRR--DTKRHSRSRSRSTPVR 1335
+ R R+ + R + RE +++ RER R + R R T +R
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Score = 40.0 bits (92), Expect = 0.015
Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 4/73 (5%)
Query: 1262 EREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRER----GRERD 1317
+ EK A + L +++R+E + R R+R+ E + G R R + +++ER G E+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 1318 RRDTKRHSRSRSR 1330
+ + R R R
Sbjct: 156 EKQERLEQRDRQR 168
Score = 33.5 bits (75), Expect = 1.4
Identities = 52/259 (20%), Positives = 89/259 (34%), Gaps = 45/259 (17%)
Query: 534 EELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRS 593
+E LA+G E+ KQ LEQ++ +R L + Q + + S
Sbjct: 144 QERELAEG-EEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETE 202
Query: 594 RSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSR 653
PD R +R++ + R +GR E + + R R
Sbjct: 203 EFPDEEQLR--------RRELLELRR----KGR--------EEKQQQRRER--------- 233
Query: 654 KSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPE 713
+D E K+ + V +LQ EP+ + Q R+L + E
Sbjct: 234 --------QDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 714 -----SAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEE 768
E+ QRL+ E+ +K E E E + Q + +++ EE
Sbjct: 286 LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEE 345
Query: 769 KEE--VTMDTSENRPENDV 785
+ E + + E R E +
Sbjct: 346 RREQQLRREQEEERREQQL 364
>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
sapiens]
Length = 434
Score = 92.4 bits (228), Expect = 3e-18
Identities = 65/209 (31%), Positives = 97/209 (46%), Gaps = 18/209 (8%)
Query: 1122 PPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSR 1181
P P + + EQ E + R A + R R+R ER+ D RSRSRS+
Sbjct: 13 PEKTSPDRDKKKEQSEVSVSPR---ASKHHYSRSRSRSR-ERKRKSDNEGRKHRSRSRSK 68
Query: 1182 DRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAER 1241
+ RR E + KS KK K++E + D R+ L S+ + +R
Sbjct: 69 EGRRHE----SKDKSSKKHKSEEHNDKEHSSDKGRER----------LNSSENGEDRHKR 114
Query: 1242 AERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGD 1301
ER R + E++ R + ER+++R RE+++ SR R+R++ R R R+R
Sbjct: 115 KERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKR 174
Query: 1302 RDRDRERDRERGRERDRRDTKRHSRSRSR 1330
R R R R R R R R R ++ SRSR R
Sbjct: 175 RIRSRSRSRSRHRHRTRSRSRTRSRSRDR 203
Score = 58.2 bits (139), Expect = 5e-08
Identities = 47/143 (32%), Positives = 70/143 (48%), Gaps = 12/143 (8%)
Query: 1132 RAEQREQERAVREQWAEREREMERRE-RTRS-EREWDRDKVREGPR---SRSRSRDRRR- 1185
R+ +R RE+ R R ER++ R+RS ER+ R + RE R SRSRSR R R
Sbjct: 129 RSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRH 188
Query: 1186 KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERA 1245
+ R++S+ + + K + E P + L R T + P P E R
Sbjct: 189 RTRSRSRTRSRSRDRKKRIEKPRRFSRSLSR-TPSPP-----PFRGRNTAMDAQEALARR 242
Query: 1246 KEREKRRKEQEEEEQKEREKEAE 1268
ER K+ +EQ E+E E++K+ E
Sbjct: 243 LERAKKLQEQREKEMVEKQKQQE 265
Score = 57.8 bits (138), Expect = 7e-08
Identities = 43/164 (26%), Positives = 83/164 (50%), Gaps = 13/164 (7%)
Query: 1135 QREQERAVREQWAEREREMERRERTRS-EREWDRDKVREGPRSRSRSRDRRRKERAKSKE 1193
+R++ ++ R + R R ERR R+RS ER+ R + RE +SRSRSR+R+ K R++S+E
Sbjct: 113 KRKERKSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERK-KSRSRSRE 171
Query: 1194 KKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
+K + +++ + +T++ S+ +K E+ R R
Sbjct: 172 RKRRIRSRSRSRSRHRHRTRSRSRTRSR----------SRDRKKRIEKPRRFSRSLSRTP 221
Query: 1254 EQEEEEQKEREKEAERERNRQLEREKRREHSRERDR-ERERERE 1296
+ +A+ R+LER K+ + RE++ E+++++E
Sbjct: 222 SPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQE 265
Score = 57.0 bits (136), Expect = 1e-07
Identities = 53/232 (22%), Positives = 95/232 (40%), Gaps = 15/232 (6%)
Query: 165 ASAESEDEMIHPEGVASLLPPDFQSSLERPELELS-----RHSPRKSSSISEEKGDSDDE 219
A++++E + + PE + PD E+ E+ +S H R S E K SD+E
Sbjct: 2 AASDTERDGLAPEKTS----PDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNE 57
Query: 220 -KPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEE 278
+ + RS R+ + S +EE D+E S R R + + E+ + +E
Sbjct: 58 GRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKER 117
Query: 279 EEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGG 338
+ ++ + + K R K ER K+RS+ +E R
Sbjct: 118 KSSRGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRR-- 175
Query: 339 RFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPP 390
RS+ +R H R + ++ S + ++R K + + S++PSPP
Sbjct: 176 --IRSRSRSRSRHRHRTRSRSRTRSRS-RDRKKRIEKPRRFSRSLSRTPSPP 224
Score = 54.7 bits (130), Expect = 6e-07
Identities = 58/210 (27%), Positives = 88/210 (41%), Gaps = 29/210 (13%)
Query: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQ- 611
E K+ H + + S+D R +SS + R + + SS RSHS RS++
Sbjct: 74 ESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRER 133
Query: 612 ------RDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSS 665
R+ ++R+ + R + + SR +SRSRSR R R S SR S S R S
Sbjct: 134 RHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSR-SRSRHRHRTRS 192
Query: 666 TSYTETKDPSSGQEV-----------ATPPVPQLQVCEPKERTSTSSSSVQARRLSQPES 714
S T ++ + + TP P + T+ + ARRL E
Sbjct: 193 RSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPPPFR----GRNTAMDAQEALARRL---ER 245
Query: 715 AEKHVTQRLQPERGSPKKCEAEEAEPPAAT 744
A+K QR E+ +K + +E AAT
Sbjct: 246 AKKLQEQR---EKEMVEKQKQQEIAAAAAT 272
Score = 48.5 bits (114), Expect = 4e-05
Identities = 47/232 (20%), Positives = 90/232 (38%), Gaps = 24/232 (10%)
Query: 568 HRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQA---RTHANPR 624
H +S S R S + + RSRS G R S +S ++ ++ + H++ +
Sbjct: 38 HHYSRSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDK 97
Query: 625 GRPKMGS----------------RSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSY 668
GR ++ S R S SRSRSR R + S RK S SR+ S
Sbjct: 98 GRERLNSSENGEDRHKRKERKSSRGRSHSRSRSRERRHRSRSRERKK-SRSRSRERKKSR 156
Query: 669 TETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERG 728
+ +++ + + +++ S S + R S+ S + +R++ R
Sbjct: 157 SRSRERKKSRSRSRERKRRIR----SRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKPRR 212
Query: 729 SPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR 780
+ + PP + + Q + ER E++E+ ++ + +
Sbjct: 213 FSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQKQQ 264
Score = 45.8 bits (107), Expect = 3e-04
Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 30/136 (22%)
Query: 1236 QKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRRE--------HSRER 1287
+++ E+ ++KEQ E R + R+R RE++R+ SR R
Sbjct: 7 ERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSR 66
Query: 1288 DRERERERERDRGDR--------------DRDRER--------DRERGRERDRRDTKRHS 1325
+E R +D+ + D+ RER DR + +ER + HS
Sbjct: 67 SKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSHS 126
Query: 1326 RSRSRSTPVRDRGGRR 1341
RSRSR R R R
Sbjct: 127 RSRSRERRHRSRSRER 142
Score = 35.0 bits (79), Expect = 0.48
Identities = 36/134 (26%), Positives = 54/134 (40%), Gaps = 22/134 (16%)
Query: 597 DSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSL 656
D SP R K+++ ++ P+ S SRSRSR R R + + RK
Sbjct: 9 DGLAPEKTSPDRDKKKEQSEVSVS------PRASKHHYSRSRSRSRERKRKSDNEGRKHR 62
Query: 657 SPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQAR-RLSQPESA 715
S SR E+KD SS + + +E SS + R RL+ E+
Sbjct: 63 SR--SRSKEGRRHESKDKSSKKH------------KSEEHNDKEHSSDKGRERLNSSENG 108
Query: 716 E-KHVTQRLQPERG 728
E +H + + RG
Sbjct: 109 EDRHKRKERKSSRG 122
Score = 32.3 bits (72), Expect = 3.1
Identities = 51/272 (18%), Positives = 96/272 (35%), Gaps = 20/272 (7%)
Query: 575 DSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHAN------PRGRPK 628
D + +S + +S S + H RS+ R + R N R R K
Sbjct: 9 DGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSK 68
Query: 629 MGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQL 688
G R S+ +S S+ + ++ K S R+ S +D +E +
Sbjct: 69 EGRRHESKDKS---SKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRSH 125
Query: 689 QVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQT 748
+ER S S + R+ S+ S E+ ++ ER + E +
Sbjct: 126 SRSRSRERRHRSRS--RERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSR 183
Query: 749 SETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVE- 807
S + S + + K+ + +R + P PP P + + D E
Sbjct: 184 SRHRHRTRSRSRTRSRSRDRKKRIEKPRRFSRSLSRTPSPP-PFRGRNTAMDAQEALARR 242
Query: 808 -------DEEKKESSLPKSFKRKISVVSATKG 832
E++++ + K +++I+ +AT G
Sbjct: 243 LERAKKLQEQREKEMVEKQKQQEIAAAAATGG 274
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 91.3 bits (225), Expect = 6e-18
Identities = 72/237 (30%), Positives = 110/237 (46%), Gaps = 23/237 (9%)
Query: 1117 LHPPPPPPVQP--PQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGP 1174
L P P PVQ Q + R+ ++ +E E +R +ERR R+RS R R
Sbjct: 217 LFPRIPVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERR-RSRSPRR-SLSPRRSPR 274
Query: 1175 RSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQI 1234
RSRSRS R + + +KE+ + E AK + R++++ D +
Sbjct: 275 RSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSI---------DRGL 325
Query: 1235 VQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQL----------EREKRREHS 1284
++ + ER + R + R + + ++RE+E E ER R+ EREK RE S
Sbjct: 326 ERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERS 385
Query: 1285 RERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
RER +E+ E + D++ R R +RD + K+HSRSRSR R R R
Sbjct: 386 RERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSR 442
Score = 83.6 bits (205), Expect = 1e-15
Identities = 50/209 (23%), Positives = 106/209 (50%), Gaps = 9/209 (4%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKS 1191
R+ R ++R + +RERE E R +R++D+++ E + R RSR+R +++R++
Sbjct: 337 RSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
Query: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
+ ++ + KE + D ++ K + S+ + A + R++ +EK
Sbjct: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS 456
Query: 1252 RKEQEEEEQK--EREKEAERERNRQLEREKRREH------SRERDRERERERERDRGD-R 1302
K + E ++K +R + + R +E+ K+REH SR+R R +ER +RD D +
Sbjct: 457 SKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSK 516
Query: 1303 DRDRERDRERGRERDRRDTKRHSRSRSRS 1331
D+ + DR R + ++ ++ +++ +
Sbjct: 517 DQSDKHDRRRSQSIEQESQEKQHKNKDET 545
Score = 82.8 bits (203), Expect = 2e-15
Identities = 73/258 (28%), Positives = 118/258 (45%), Gaps = 73/258 (28%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSER--EWDRDKVREGPRSRSRSRDRR--RKE 1187
R +RE+ER E+ A +ERE ERR +R E R + RE RSRSRSRDR+ R++
Sbjct: 293 RELEREKERQRLEREA-KEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD 351
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKE 1247
R + +EK++E+ + + + K + ++E ER ER++E
Sbjct: 352 RDREREKENERGRRRDRD---------YDKERGN--------------EREKER-ERSRE 387
Query: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRRE--HSRERDRERE---RERERDRGDR 1302
R K ++ + E E+K+ +++ + R+R +R+ ++E HSR R RER+ R R R+ G R
Sbjct: 388 RSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKR 447
Query: 1303 DRDRERDR---------------------------------------ERGRERDRRDTKR 1323
R R +++ E+ R+R R +
Sbjct: 448 SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS 507
Query: 1324 HSRSRSRSTPVRDRGGRR 1341
H R S S D+ RR
Sbjct: 508 HKRDHSDSKDQSDKHDRR 525
Score = 80.5 bits (197), Expect = 1e-14
Identities = 61/221 (27%), Positives = 106/221 (47%), Gaps = 47/221 (21%)
Query: 1124 PVQPPQHPRAEQREQE---RAVREQWAEREREMERRERTRSEREWDRDKVREGPRS---- 1176
P + P+ R+ +E + ++ ERE+E +R ER ERE +R + R R
Sbjct: 269 PRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERR 328
Query: 1177 RSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQ 1236
RSRSR+R R R++S+++K +++++ +E +
Sbjct: 329 RSRSRERHRS-RSRSRDRKGDRRDRDRER------------------------------E 357
Query: 1237 KEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296
KE ER R + + E E+++ER +E +E+ + E E+++ H ++D R R+
Sbjct: 358 KENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKK-HKEDKDDRRHRD-- 414
Query: 1297 RDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDR 1337
D+ D ++++ R R RER K SRSRSR+ R R
Sbjct: 415 -DKRDSKKEKKHSRSRSRER-----KHRSRSRSRNAGKRSR 449
Score = 57.8 bits (138), Expect = 7e-08
Identities = 71/323 (21%), Positives = 136/323 (42%), Gaps = 17/323 (5%)
Query: 71 PLQALRVTDLKAALEQRGLAKSGQKSAL-----VKRLKGALMLENLQKHSTPHAAFQPNS 125
P+ + D + R + K G++ A V+R + +L +P + + S
Sbjct: 222 PVPVQKNIDQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRS-RSRS 280
Query: 126 QIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPP 185
E +SF ++ LE+++E RQRLEREA+E E E + S D + S
Sbjct: 281 HHREGHGSSSFDRE-LEREKE--RQRLEREAKE-REKERRRSRSIDRGLERRRSRSRERH 336
Query: 186 DFQS-SLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQ 244
+S S +R R R+ + + D D +K R ER R R +K
Sbjct: 337 RSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
Query: 245 PAEEEEDQETPSRNLRVRADR--NLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILK 302
EE++ +E + R R D+ + K ++ E + + G++SR K
Sbjct: 397 EVEEKKHKEDKD-DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEK 455
Query: 303 EFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMK 362
K + E + + +T S E+ + + S+E++RK ++++ K
Sbjct: 456 SSKHKNESKEKSNKRSRSGSQGRTDSVEK---SKKREHSPSKEKSRKRSRSKERSHKRDH 512
Query: 363 TTSPLEEEEREIKSSQGLKEKSK 385
+ S + ++ + + SQ ++++S+
Sbjct: 513 SDSKDQSDKHDRRRSQSIEQESQ 535
Score = 57.0 bits (136), Expect = 1e-07
Identities = 64/263 (24%), Positives = 107/263 (40%), Gaps = 28/263 (10%)
Query: 194 PELELS-RHSPRKSSSISEEK-GDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEED 251
P LS R SPR+S S S + G R+ ER R R R AK E + D
Sbjct: 263 PRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSID 322
Query: 252 QETPSRNLRVRA----------------DRNLKTEEEEEEEEEEEEDDEEEEGDD-EGQK 294
+ R R R DR+ + E+E E + D ++E G++ E ++
Sbjct: 323 RGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKER 382
Query: 295 SREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLAR 354
R KE + G E+ K +E D+R + E+ +RS+E +S
Sbjct: 383 ERSRERSKEQRSRG-EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRS 441
Query: 355 QQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEET 414
+ K ++ S + + + +S + ++S+S S R K E + S+E++
Sbjct: 442 RNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKK----REHSPSKEKS 497
Query: 415 PPPLLTKEASSPPPHPQLHSEEE 437
+KE S H + HS+ +
Sbjct: 498 RKRSRSKERS----HKRDHSDSK 516
Score = 49.7 bits (117), Expect = 2e-05
Identities = 57/298 (19%), Positives = 107/298 (35%), Gaps = 29/298 (9%)
Query: 540 KGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSS 599
K I ++ +P +K+G+ + + +++ S RS S S RSRSRS
Sbjct: 227 KNIDQQIKTRPRKIKKDGKEGAEEI--DRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE 284
Query: 600 GSRSHSPLR--------------SKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRS 645
G S S R +K+R+ + R+ + RG + SRS RSRSRSR
Sbjct: 285 GHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRD 344
Query: 646 RSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQ 705
R R R+ +D +E + + + + S V+
Sbjct: 345 RKGDRRDRDR-----EREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVE 399
Query: 706 ARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHT 765
++ + + +H R + + E+ + ++ + +++ +R
Sbjct: 400 EKKHKEDKDDRRH--------RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSR 451
Query: 766 VEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRK 823
+EK + S+ + D V + E S E+ ++ S K K
Sbjct: 452 SKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK 509
Score = 44.7 bits (104), Expect = 6e-04
Identities = 33/129 (25%), Positives = 60/129 (46%), Gaps = 4/129 (3%)
Query: 548 KQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSS---SSSSRSRSRSPDSSGSRSH 604
K+ S ++K+ R S + HR + + ++ RS S S SS ++ S+ + SRS
Sbjct: 416 KRDSKKEKKHSR-SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSG 474
Query: 605 SPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDS 664
S R+ + ++ R H+ + + + SRS S R S S+ S + S + ++S
Sbjct: 475 SQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQES 534
Query: 665 STSYTETKD 673
+ KD
Sbjct: 535 QEKQHKNKD 543
Score = 42.7 bits (99), Expect = 0.002
Identities = 40/171 (23%), Positives = 68/171 (39%), Gaps = 8/171 (4%)
Query: 511 DYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRL 570
DY ++ E E +R K + ++G EE + E K+ RR S +
Sbjct: 369 DYDKERGNEREKERERSRERSKEQR---SRGEVEE---KKHKEDKDDRRHRDDKRDSKKE 422
Query: 571 KQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKM- 629
K+ + S S S S SR+ + S S +++ ++ + R+ + +GR
Sbjct: 423 KKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSV 482
Query: 630 -GSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQE 679
S+ S S+ +SR RS S S+D S + + S QE
Sbjct: 483 EKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQE 533
Score = 38.1 bits (87), Expect = 0.057
Identities = 40/195 (20%), Positives = 76/195 (38%), Gaps = 10/195 (5%)
Query: 142 EKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRH 201
++++E +R R R+ + E E E + + + + + RH
Sbjct: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRH 412
Query: 202 SPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRV 261
K S E+K + RK R SR R A S + + + +++ N R
Sbjct: 413 RDDKRDSKKEKKHSRSRSRERKHRSR-SRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRS 471
Query: 262 RADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMD 321
R+ +T+ E+ ++ E +E KSR+ KE + + K +
Sbjct: 472 RSGSQGRTDSVEKSKKREHSPSKE--------KSRKRSRSKE-RSHKRDHSDSKDQSDKH 522
Query: 322 ERPKTRSQEQEVLER 336
+R +++S EQE E+
Sbjct: 523 DRRRSQSIEQESQEK 537
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 91.3 bits (225), Expect = 6e-18
Identities = 59/205 (28%), Positives = 110/205 (53%), Gaps = 28/205 (13%)
Query: 1118 HPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSERE-WDRDKVREGPRS 1176
H PPPP + QHP + R+ R +++ E E W + + ++ S
Sbjct: 405 HLPPPPKLLAQQHPPPD--------RQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEIS 456
Query: 1177 RSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQ 1236
+ R R+R+E +E++ E++ KA K LD+ L + + Q
Sbjct: 457 AAVERARKRREE---EERRMEEQRKAACAEKLKRLDEK------------LGILEKQPSP 501
Query: 1237 KEAERAERAKEREKRR---KEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERER 1293
+E ER KERE+ + KEQE+E +KEREK+ ER++ ++ E EK +E RE ++ER++
Sbjct: 502 EEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQ 561
Query: 1294 ERERDRGDRDRDRERDRERGRERDR 1318
E+E++ +R +++E++ ++ +E+++
Sbjct: 562 EKEKEL-ERQKEKEKELQKMKEQEK 585
Score = 76.3 bits (186), Expect = 2e-13
Identities = 170/845 (20%), Positives = 317/845 (37%), Gaps = 150/845 (17%)
Query: 178 GVASLLPPDFQSSLERPELELSRHSPRKSSSI--------SEEKGDSDDEKPRKGERRSS 229
G +S LPP P+L +H P ++ S+++ +DE ++ R+ S
Sbjct: 401 GTSSHLPPP-------PKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQS 453
Query: 230 RVRQA--RAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEE 287
+ A RA K E + EE+ + + L+ R D L E++ EE E + E+E
Sbjct: 454 EISAAVERARKRREEEERRMEEQRKAACAEKLK-RLDEKLGILEKQPSPEEIREREREKE 512
Query: 288 GDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA 347
+ RE + KE ++E E+ R K E E+ K +EQE + + +++
Sbjct: 513 ------REREKELEKEQEQEREK-EREKDRERQQEKEKELEKEQE---KQREMEKERKQE 562
Query: 348 RKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQ 407
++ L RQ+++++ +E+E E++ + E+ P P L +K E
Sbjct: 563 KEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQE----SEN 618
Query: 408 TASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVS 467
+ ++EE P + T++ S+ SE+E P+ + + P + + R ++S
Sbjct: 619 SCNKEEEP--VFTRQDSN-------RSEKEATPV--------VHETEPESGSQPRPAVLS 661
Query: 468 QHTVQLVGGLSP-LSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSA 526
+ Q L P + + ++ ++ VLP T+ + + P R
Sbjct: 662 GYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLP----QTVPSQPSSSTVPPPPHRPL 717
Query: 527 -QPLPLKIEELALAKGITEECLKQPSL---EQKEGRRASHTLLPSHRLKQSADSSSSRSS 582
QP+ + LA + G L S GR A +P R
Sbjct: 718 YQPMQPHPQHLA-SMGFDPRWLMMQSYMDPRMMSGRPAMD--IPPIHPGMIPPKPLMRRD 774
Query: 583 SSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDV--AQARTHANPRGRPKMGSRSTSESRSR 640
S + S S + +R H+ S+ R + + HA P+ ++T+ +
Sbjct: 775 QMEGSPNSSESFEHIARSARDHAISLSEPRMLWGSDPYPHAEPQ-------QATTPKATE 827
Query: 641 SRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTS 700
RS ++ ++ ++ S + + QL+ PK
Sbjct: 828 EPEDVRSEAALDQEQITAAYSVEHN---------------------QLEA-HPKADFIRE 865
Query: 701 SSSVQARRL--SQPESAEKHVTQRLQPERGSPKKC-EAEEAEPPAATQPQTSETQTSHLP 757
SS Q ++ E H T + + C EA + + +A Q + S
Sbjct: 866 SSEAQVQKFLSRSVEDVRPHHT-----DANNQSACFEAPDQKTLSAPQEERISAVESQPS 920
Query: 758 ESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLP 817
+ H ++ D + P +P+ D +RPE ++ KKE +
Sbjct: 921 RKRSVSHGSNHTQKP--DEQRSEPSAGIPKVTSRCIDSKEPIERPE----EKPKKEGFIR 974
Query: 818 KSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPD 877
S K V +K + RWG ++ +++ + ++ P
Sbjct: 975 SSEGPKPEKVYKSKS---------------ETRWGPRPSSNRRE---EVNDRPVRRSGPI 1016
Query: 878 IKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREE 937
KP+ + E+ +R +G +K K+ V VV E +
Sbjct: 1017 KKPVLRD------------MKEEREQRKEKEG--EKAEKVTEKV--VVKPE-------KT 1053
Query: 938 EEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPV 997
E+++ P PP PP ++PPP + E +K +T T ++Q+ S + +PV
Sbjct: 1054 EKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETAT---LAQKPSQDTEKPLEPV 1110
Query: 998 RTAQV 1002
T QV
Sbjct: 1111 STVQV 1115
Score = 70.9 bits (172), Expect = 8e-12
Identities = 151/767 (19%), Positives = 292/767 (38%), Gaps = 122/767 (15%)
Query: 138 KQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLE----- 192
KQ + + E+ +QR +++ +A +E A E+E E + L+
Sbjct: 435 KQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGI 494
Query: 193 ---RPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAE-- 247
+P E R R+ E++ + + E+ R+ ER R RQ K E Q +
Sbjct: 495 LEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQRE 554
Query: 248 ------EEEDQETPSRNLRVRADRNLKTEEEE--EEEEEEEEDD-------------EEE 286
+E+++E + + + + +K +E+E E+E E+ ++ E++
Sbjct: 555 MEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQ 614
Query: 287 EGDDEGQKSREAPILKEFKEEGEE-----IPRVKPEEMMDERPKTRSQEQEVLERG--GR 339
E ++ K E ++ E+ + +PE RP S + ++ R
Sbjct: 615 ESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPPR 674
Query: 340 FTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKA 399
F R QE+ ++ +QQQ+ + T P + SS + P + A
Sbjct: 675 FQRQQEQMKQQQWQQQQQQGVLPQTVPSQP-----SSSTVPPPPHRPLYQPMQPHPQHLA 729
Query: 400 SLVALPEQTASEEETPPPLLTKEASS--PPPHPQLHSEEEI---EPMEGPAPPVLIQLSP 454
S+ P + P +++ + PP HP + + + + MEG SP
Sbjct: 730 SMGFDPRWLMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKPLMRRDQMEG---------SP 780
Query: 455 PNTDA------DTRELLVSQHTVQLVGGLSPLSSPSDTKAESP-AEKVPEE--SVLPLVQ 505
++++ R+ +S +++ G P +A +P A + PE+ S L Q
Sbjct: 781 NSSESFEHIARSARDHAISLSEPRMLWGSDPYPHAEPQQATTPKATEEPEDVRSEAALDQ 840
Query: 506 KSTLADYSA---QKDLEPESDRSAQPLPLKIEELALAKGI-------TEECLKQPSLEQK 555
+ A YS Q + P++D + ++++ L++ + T+ + E
Sbjct: 841 EQITAAYSVEHNQLEAHPKADFIRESSEAQVQKF-LSRSVEDVRPHHTDANNQSACFEAP 899
Query: 556 EGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSR----SRSPDSSG-----SR---S 603
+ + S P + +S SR S S S+ ++ RS S+G SR S
Sbjct: 900 DQKTLS---APQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDS 956
Query: 604 HSPL-RSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSP-GVS 661
P+ R +++ + ++ +P+ +S SE+R R SSN R+ ++ V
Sbjct: 957 KEPIERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPR-----PSSNRREEVNDRPVR 1011
Query: 662 RDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQ 721
R +D +E + KE+ + V + + +PE EK
Sbjct: 1012 RSGPIKKPVLRDMKEERE------------QRKEKEGEKAEKVTEKVVVKPEKTEKKDLP 1059
Query: 722 RLQPERGSPKKCEAEEAEPPAATQPQ---TSETQTSHLPESERIHHTVEEKEEVTMDTSE 778
P P + + PP + + ++ET T S+ +E V ++ +
Sbjct: 1060 PPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAV 1119
Query: 779 NRPENDVPEPPMPIADQ-----VSND---DRPEGSVEDEEKKESSLP 817
P+ ++ +S D +RP KKES+LP
Sbjct: 1120 KTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLP 1166
Score = 53.1 bits (126), Expect = 2e-06
Identities = 98/476 (20%), Positives = 178/476 (37%), Gaps = 92/476 (19%)
Query: 834 PAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHAD 893
P S+T G GR S A+ ++PSI +E + ++ +A D
Sbjct: 268 PPSLSETNKGLRGRGPP--PSWASEPERPSILSASE-----LKELDKFDNLDAEADEGWA 320
Query: 894 DSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQ 953
+++ D TE+ ++G + ++ G + E E + E + +
Sbjct: 321 GAQMEVDYTEQLNFSDDDEQGSNSPKE------NNSEDQGSKASENNENKKETDEVSNTK 374
Query: 954 VSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNI 1013
S ++ PA+ V KV G S +Q++ S P AQ PP
Sbjct: 375 SSSQI----PAQPSVAKVPYGKG---PSFNQERGTSSHLPPPPKLLAQQHPPPD------ 421
Query: 1014 VHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVK 1073
R G+ + E+ W + + ++ + VE A R +
Sbjct: 422 -------RQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEIS-AAVERARKRREEEE--R 471
Query: 1074 WPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRA 1133
+ K CA+ ++ LD G+L +PS + E+ R
Sbjct: 472 RMEEQRKAACAEKLKR--LDEKLGILEKQPSPEEIRER-------------------ERE 510
Query: 1134 EQREQERAV-REQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSR-DRRRKERAKS 1191
++RE+E+ + +EQ ERE+E E+ + E+E + +K +E R + R + KE +
Sbjct: 511 KEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQ 570
Query: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
KEK+ E ++ ++E +L +KE E+ E EK
Sbjct: 571 KEKEKELQKMKEQEKECEL-------------------------EKEREKLE-----EKI 600
Query: 1252 RKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERE---RERERDRGDRDR 1304
+ E ++E+E N++ E R+ S ++E E E + G + R
Sbjct: 601 EPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPR 656
Score = 48.9 bits (115), Expect = 3e-05
Identities = 190/1075 (17%), Positives = 368/1075 (34%), Gaps = 163/1075 (15%)
Query: 2 WRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGR-------------WRKLPKMPEA 48
W+ R +G RG Y GR + G++ GR +R E
Sbjct: 1171 WKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRAEH 1230
Query: 49 VGTDPSTSRKMAELEEVTLDGKPLQALR-----VTDLKAALEQRGLAKSG-QKSALVKRL 102
+ + P R+ +E + D + + R TD + + + K K L KR
Sbjct: 1231 IPSGPLRQREESETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKRE 1290
Query: 103 KGALMLENLQKHSTPHAAFQPNS--QIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAA 160
+ EN +K PH++F+P++ +I + + +++ + + L +
Sbjct: 1291 ERP---EN-KKPVKPHSSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGG 1346
Query: 161 ELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEK 220
+ P G P S+L RP ++ +PR+S E G E
Sbjct: 1347 TFRRGGRD-------PGG-----RPSRPSTLRRPAYRDNQWNPRQSEVPKPEDG----EP 1390
Query: 221 PRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEE 280
PR+ E+ R K PA E ++ P+R R + E E +
Sbjct: 1391 PRRHEQFIPIAADKRPPKFERKFDPARERPRRQRPTRPPRQDKPPRFRRLREREAASKSN 1450
Query: 281 EDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMD---ERPKTRSQEQEVLERG 337
E ++E P+ G + P + + D E +T S+ + ER
Sbjct: 1451 EVVAVPTNGTVNNVAQE-PVNTLGDISGNKTPDLSNQNSSDQANEEWETASESSDFNERR 1509
Query: 338 GRFTRSQEEARKSHLA----------RQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSP 387
R + + + R+ ++ + P++ + R + + G + ++
Sbjct: 1510 ERDEKKNADLNAQTVVKVGENVLPPKREIAKRSFSSQRPVDRQNR--RGNNGPPKSGRNF 1567
Query: 388 SPPR-------LTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEI-- 438
S PR ++ K+ P T + + P Q +S++
Sbjct: 1568 SGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDSTGK 1627
Query: 439 ---EPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKV 495
+P GP P DA ++ L + +V ++ P T E P +
Sbjct: 1628 KREDPKPGPKKP------KEKVDALSQFDLNNYASVVIID-----DHPEVTVIEDPQSNL 1676
Query: 496 PEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKI--EELALAKGITEECLKQPSLE 553
++ +V K QK L+ E R + +++ ++ A KG ++ P
Sbjct: 1677 NDDGFTEVVSK------KQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFA 1730
Query: 554 QKEG-----RRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLR 608
+K+ ++S ++ P +S+S +S+S+ + + P S+ +P+
Sbjct: 1731 KKQATGIQQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTS----APVP 1786
Query: 609 SKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSY 668
+ A T A P + S S S S S S SA++ + S +P + +
Sbjct: 1787 ASTLAPVLASTSAPVPASP-LAPVSASASVSASVPASTSAAAITSSS-APASAPAPTPIL 1844
Query: 669 TETKDPSSGQEVATPPVPQL-----QVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRL 723
P+S +A+ +P L P + SS + ++ + L
Sbjct: 1845 ASVSTPASVTILASASIPILASALASTSAPTPAPAASSPAAPVITAPTIPASAPTASVPL 1904
Query: 724 QPERGS-----PKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSE 778
P S P A PPA Q Q + H V+ + T +S+
Sbjct: 1905 APASASAPAPAPTPVSAPNPAPPAPAQTQA------------QTHKPVQNPLQTTSQSSK 1952
Query: 779 NRPENDVPEPPMPIADQVSNDDRPEG--SVEDEEKKESSLPKSFKRKISVVSATKGVPAG 836
P P +P A + D S++ + + + + K++ + +
Sbjct: 1953 QPP----PSIRLPSAQTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKK 2008
Query: 837 NSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSR 896
QP W + PS +E K+ GQE+ +++ D +
Sbjct: 2009 LGPISPPQPPSVSAWNKPLTSFGSAPS----SEGAKN---------GQESGLEIGTDTIQ 2055
Query: 897 ISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSV 956
+ N ++ V V+ + + +E+ +K+P A P+ Q
Sbjct: 2056 FGAPASNGNENE------------VVPVLSEKSADKIPEPKEQRQKQPRA-GPIKAQKLP 2102
Query: 957 EVALPPPAEHEVKKVTLGDTLTRRSI----------SQQKSGVSITIDDPVRTAQ 1001
+++ EH+ + +L R + ++ S ++ DPV T +
Sbjct: 2103 DLSPVENKEHKPGPIGKERSLKNRKVKDAQQVEPEGQEKPSPATVRSTDPVTTKE 2157
Score = 39.3 bits (90), Expect = 0.026
Identities = 68/282 (24%), Positives = 106/282 (37%), Gaps = 46/282 (16%)
Query: 1102 RPSETKTEEQ-GIPRPLH---PPPPPPVQPPQHPRAEQ--REQERAVREQWAEREREME- 1154
+P E ++E GIP+ P +P + P+ E R E E+ + + E
Sbjct: 934 KPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRW 993
Query: 1155 --RRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQE----EPPA 1208
R R E DR R GP + RD + +ER + KEK+ EK EK E +P
Sbjct: 994 GPRPSSNRREEVNDRPVRRSGPIKKPVLRDMK-EEREQRKEKEGEKAEKVTEKVVVKPEK 1052
Query: 1209 KLLDDLFRKTKAAPCIYWLPLTDSQI---VQKEAERAERAKEREKRRKEQEEEEQK---- 1261
DL P P+ + +Q EAE+ + +K ++ E+
Sbjct: 1053 TEKKDL--PPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPV 1110
Query: 1262 ----------------------EREKEAERERNRQLEREKRREHSRERDRERERERERDR 1299
+ EK+ E+ ++ L E+ R SR ++ R
Sbjct: 1111 STVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTY 1170
Query: 1300 GDRDRDRERDRERG-RERDRRDTKRHSRSRSRSTPVRDRGGR 1340
R+R+ ++G R R R + RS S R RGGR
Sbjct: 1171 WKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGR 1212
Score = 37.0 bits (84), Expect = 0.13
Identities = 76/391 (19%), Positives = 140/391 (35%), Gaps = 55/391 (14%)
Query: 43 PKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRL 102
P +V + ++K E G P R D K +E+ + +K ++
Sbjct: 919 PSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERP--EEKPKKEGFIRSS 976
Query: 103 KGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAEL 162
+G + + S +P+S EE++ + K+ L + ERE R+ E
Sbjct: 977 EGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQRKEKEG 1036
Query: 163 EEASAESEDEMIHPEGVASL-LPPD----------FQSSLERPELELSRHSPRKSSSISE 211
E+A +E ++ PE LPP S+ P + P ++
Sbjct: 1037 EKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLA 1096
Query: 212 EKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPA-----EEEEDQETPSRNL---RVRA 263
+K D EKP + S V+ A K A EE++ ++ S++L R R
Sbjct: 1097 QKPSQDTEKPLE---PVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPRP 1153
Query: 264 DRNLKTEEE---------EEEEEEEEEDDEEEEGDDEGQ--------------------- 293
D ++E +E E + D+ G G+
Sbjct: 1154 DSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGRGGRG 1213
Query: 294 KSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLA 353
+R+ P ++ K E IP + + ++ S + EV+ + R R E S +
Sbjct: 1214 HTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRR-QRGSETDTDSEIH 1272
Query: 354 RQQQEKEMKTTSPLEEEEREIKSSQGLKEKS 384
+K+ + L + E ++ + +K S
Sbjct: 1273 ESASDKDSLSKGKLPKREERPENKKPVKPHS 1303
Score = 33.5 bits (75), Expect = 1.4
Identities = 54/236 (22%), Positives = 85/236 (36%), Gaps = 36/236 (15%)
Query: 1102 RPSETKT-------EEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREME 1154
RPS T + Q PR P P +PP R E+ + +R + E
Sbjct: 1358 RPSRPSTLRRPAYRDNQWNPRQSEVPKPEDGEPP-------RRHEQFIPIAADKRPPKFE 1410
Query: 1155 R-----RERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKE----KKSEKKEKAQEE 1205
R RER R +R + + PR R R R R+ +KS E + +E
Sbjct: 1411 RKFDPARERPRRQRPTRPPRQDKPPRFR---RLREREAASKSNEVVAVPTNGTVNNVAQE 1467
Query: 1206 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKERE--KRRKEQEEEEQKER 1263
P L D KT L++ + E E A E R+E++E++ +
Sbjct: 1468 PVNTLGDISGNKTP--------DLSNQNSSDQANEEWETASESSDFNERRERDEKKNADL 1519
Query: 1264 EKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRR 1319
+ + + KR R +R +R+ RG+ + G +RR
Sbjct: 1520 NAQTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERR 1575
Score = 33.5 bits (75), Expect = 1.4
Identities = 80/397 (20%), Positives = 141/397 (35%), Gaps = 48/397 (12%)
Query: 384 SKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEG 443
S S P A ++ P AS PL AS+P P P S
Sbjct: 1870 STSAPTPAPAASSPAAPVITAPTIPASAPTASVPLAPASASAPAPAPTPVS------APN 1923
Query: 444 PAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPL 503
PAPP +P T A T + P+ +P T ++S +++ P LP
Sbjct: 1924 PAPP-----APAQTQAQTHK---------------PVQNPLQTTSQS-SKQPPPSIRLPS 1962
Query: 504 VQKSTLADYSAQ-KDLE-PES--DRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRR 559
Q DY A K ++ P+S +A+ K+ A+ I+++ L S Q
Sbjct: 1963 AQTPNGTDYVASGKSIQTPQSHGTLTAELWDNKVAPPAVLNDISKK-LGPISPPQPPSVS 2021
Query: 560 ASHTLLPSHRLKQSAD-SSSSRSSSSSSSSSRSRSRSPDSSGSRSH-SPLRSKQ------ 611
A + L S S++ + + + S + + +P S+G+ + P+ S++
Sbjct: 2022 AWNKPLTSFGSAPSSEGAKNGQESGLEIGTDTIQFGAPASNGNENEVVPVLSEKSADKIP 2081
Query: 612 --RDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYT 669
++ Q + A P K+ S E++ + +SL +D+
Sbjct: 2082 EPKEQRQKQPRAGPIKAQKLPDLSPVENKEH-----KPGPIGKERSLKNRKVKDAQQVEP 2136
Query: 670 ETKD-PSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERG 728
E ++ PS +T PV + E ++ + + +A++ VT P
Sbjct: 2137 EGQEKPSPATVRSTDPVTTKETKAVSEMSTEIGTMISVSSAEYGTNAKESVTDYTTPSSS 2196
Query: 729 SPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHT 765
P + T LP+ E I +
Sbjct: 2197 LPNTVATNNTKMEDTLVNNVPLPNTLPLPKRETIQQS 2233
Score = 32.7 bits (73), Expect = 2.4
Identities = 53/252 (21%), Positives = 94/252 (37%), Gaps = 49/252 (19%)
Query: 1107 KTEEQGIPRPLHPPPPPPVQPPQ-----------HPRAEQ-REQERAVREQWAEREREME 1154
KTE++ +P PPPPP QPP P AE+ E A Q ++ E
Sbjct: 1052 KTEKKDLP-----PPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKP 1106
Query: 1155 RRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDL 1214
+ + E V + + ++ ++ E+ SK+ E + + P K
Sbjct: 1107 LEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIE-RPRPDSRPAVK----- 1160
Query: 1215 FRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQ 1274
+++ P YW KEA + ++ R + + E + R +
Sbjct: 1161 -KESTLPPRTYW----------KEARERDWFPDQGYRGRGRGEYYSRGRSYRGSYGGRGR 1209
Query: 1275 LEREKRREHSRERD-------------RERERERER-DRGDRDRDRERDRERGRERDRRD 1320
R R++ + RD R+RE R + D + +R R+RG E D D
Sbjct: 1210 GGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVPKRRRQRGSETD-TD 1268
Query: 1321 TKRHSRSRSRST 1332
++ H + + +
Sbjct: 1269 SEIHESASDKDS 1280
>gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo sapiens]
Length = 437
Score = 90.1 bits (222), Expect = 1e-17
Identities = 64/203 (31%), Positives = 100/203 (49%), Gaps = 43/203 (21%)
Query: 1132 RAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKS 1191
R ++R + + +R+RE ERRER+R +RDK RE R RSRSRDRRR+ R++
Sbjct: 218 RYDERPGPSPLPHRDRDRDRERERRERSR-----ERDKERE--RRRSRSRDRRRRSRSRD 270
Query: 1192 KEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKR 1251
KE++ +E+++++ D RK +++ +E R ER ++ E R
Sbjct: 271 KEERRRSRERSKDK-------DRDRKRRSSR-------------SRERARRERERKEELR 310
Query: 1252 RKEQEEEEQKEREK----------------EAERERNRQLEREKRREHSRERDRERERER 1295
+ E E + E+ R +RE+RR H ER+R R+R+R
Sbjct: 311 GGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDR 370
Query: 1296 ERDRGDRDRDRERDRERGRERDR 1318
+RDR + ER ERGR+ R
Sbjct: 371 DRDRDREHKRGERGSERGRDEAR 393
Score = 84.0 bits (206), Expect = 9e-16
Identities = 63/194 (32%), Positives = 95/194 (48%), Gaps = 24/194 (12%)
Query: 1122 PPPVQPPQHPRAEQREQERAVREQWAEREREMER-RERTRSEREWDRDKV-REGPRSRSR 1179
P P P R RE+ER R + ++ERE R R R R R RDK R R RS+
Sbjct: 223 PGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSK 282
Query: 1180 SRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEA 1239
+DR RK R+ S+ ++ ++E+ ++E D+ ++A P D
Sbjct: 283 DKDRDRKRRS-SRSRERARRERERKEELRGGGGDMAEPSEAGDA----PPDD-------- 329
Query: 1240 ERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDR 1299
E + E+K R+++ ER R+ + ERE+R R+RDR+R+R+RE R
Sbjct: 330 -----GPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERR----RDRDRDRDRDREHKR 380
Query: 1300 GDRDRDRERDRERG 1313
G+R +R RD RG
Sbjct: 381 GERGSERGRDEARG 394
Score = 67.4 bits (163), Expect = 9e-11
Identities = 39/76 (51%), Positives = 48/76 (63%), Gaps = 8/76 (10%)
Query: 1269 RERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERD-------RERGRERDRRDT 1321
R+R+R ERE RRE SRERD+ERER R R R R R R RD RER +++DR
Sbjct: 231 RDRDRDRERE-RRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRK 289
Query: 1322 KRHSRSRSRSTPVRDR 1337
+R SRSR R+ R+R
Sbjct: 290 RRSSRSRERARRERER 305
Score = 66.2 bits (160), Expect = 2e-10
Identities = 40/112 (35%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 1231 DSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRE 1290
D I + R ER + ++RE+E RER+R+ ++E+ R SR RDR
Sbjct: 205 DVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERE-RRERSRERDKERERRRSRSRDRR 263
Query: 1291 RERERERDRGDRDRDRERDRERGRERDRRDTK---RHSRSRSRSTPVRDRGG 1339
R R R RD+ +R R RER +++ R+R RR ++ R R R R +R GG
Sbjct: 264 R-RSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGG 314
Score = 63.5 bits (153), Expect = 1e-09
Identities = 46/199 (23%), Positives = 77/199 (38%), Gaps = 61/199 (30%)
Query: 1171 REGP-----RSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIY 1225
R GP R R R R+R R+ER++ ++K+ E++
Sbjct: 222 RPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRS---------------------- 259
Query: 1226 WLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSR 1285
++ R R++++E+RR+ +E + K+R+++ R+R+ R +R
Sbjct: 260 -----------RDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEE 308
Query: 1286 ERDRERERERERDRGD-----------------------RDRDRERDRERGRERDRRDTK 1322
R + + GD RDRDRER R ER+RR +
Sbjct: 309 LRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDR 368
Query: 1323 RHSRSRSRSTPVRDRGGRR 1341
R R R +RG R
Sbjct: 369 DRDRDRDREHKRGERGSER 387
Score = 37.4 bits (85), Expect = 0.098
Identities = 42/197 (21%), Positives = 75/197 (38%), Gaps = 27/197 (13%)
Query: 200 RHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNL 259
RHS R +S +E+ R +R R R+ R+ E D+E R
Sbjct: 209 RHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERS-----------RERDKERERRRS 257
Query: 260 RVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEI-----PRV 314
R R R ++EE E ++++ D + + SR + +E EE+
Sbjct: 258 RSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMA 317
Query: 315 KPEEMMDERP------KTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLE 368
+P E D P + + E GR E R+SH + +++ ++
Sbjct: 318 EPSEAGDAPPDDGPPGELGPDGPDGPEEKGR--DRDRERRRSHRSERERRRDRDRD---R 372
Query: 369 EEEREIKSSQGLKEKSK 385
+ +RE K + E+ +
Sbjct: 373 DRDREHKRGERGSERGR 389
Score = 37.4 bits (85), Expect = 0.098
Identities = 42/171 (24%), Positives = 75/171 (43%), Gaps = 22/171 (12%)
Query: 194 PELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQE 253
P + R R+ S E+ D E+ R+ R R R++R+ E + E +D++
Sbjct: 229 PHRDRDRDRERERRERSRER---DKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKD 285
Query: 254 TPSRNLRVRADRNLKTEEEEEEEEEE------EEDDEEEEGD---DEGQKSREAPILKEF 304
R+ + R+ R+ + E E +EE + + E GD D+G P +
Sbjct: 286 ---RDRKRRSSRSRERARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDG 342
Query: 305 KEE-GEEIPRVKPEEMMDERPKTRSQEQE-----VLERGGRFT-RSQEEAR 348
EE G + R + ER + R ++++ +RG R + R ++EAR
Sbjct: 343 PEEKGRDRDRERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEAR 393
Score = 35.8 bits (81), Expect = 0.28
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 15/76 (19%)
Query: 1121 PPPPVQP--PQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRS 1178
PP + P P P + R+++R ERR RSERE RD+ R+ R R
Sbjct: 331 PPGELGPDGPDGPEEKGRDRDR-------------ERRRSHRSERERRRDRDRDRDRDRE 377
Query: 1179 RSRDRRRKERAKSKEK 1194
R R ER + + +
Sbjct: 378 HKRGERGSERGRDEAR 393
Score = 33.5 bits (75), Expect = 1.4
Identities = 29/111 (26%), Positives = 44/111 (39%), Gaps = 7/111 (6%)
Query: 575 DSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRST 634
D +S S R R D R RS++RD + R + R R +
Sbjct: 214 DDTSRYDERPGPSPLPHRDRDRDRERERRE---RSRERDKERERRRSRSRDRRRRSRSRD 270
Query: 635 SESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDP--SSGQEVATP 683
E R RSR RS+ + ++ S SR+ + E K+ G ++A P
Sbjct: 271 KEERRRSRERSKDKDRDRKRRSSR--SRERARRERERKEELRGGGGDMAEP 319
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 86.3 bits (212), Expect = 2e-16
Identities = 161/791 (20%), Positives = 280/791 (35%), Gaps = 117/791 (14%)
Query: 122 QPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEM-IHPEGVA 180
+PN + + +EK +R++RE + + A+ E+ + E +
Sbjct: 1817 KPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKMEAEKIT 1876
Query: 181 SLLPPDFQSSLERPE--LELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAK 238
+ + LE PE L LSR R S+ GD ++ P K RV + R +
Sbjct: 1877 RTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQPRVTRKRLER 1936
Query: 239 LSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEE--EDDEEEEGDDEGQKSR 296
E +E P+ R R + + +EEEE E +E E + EG + +
Sbjct: 1937 --------ELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK 1988
Query: 297 EAPILKEFKEEGEEIPRV---KPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLA 353
A ++G+ P+V +PE + P+ +E + + E+ R A
Sbjct: 1989 TAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA 2048
Query: 354 RQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR----KKASLVALPEQTA 409
+K T+P+E E++ + K K RL D+ K P A
Sbjct: 2049 GT--DKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAA 2106
Query: 410 S---EEETPPPLLTKEAS-SPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTREL- 464
+ E E+ ++ E S SP L S+ + +P++ P +S + +L
Sbjct: 2107 AQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEATQLA 2166
Query: 465 --LVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKS----TLADYSAQKDL 518
+ + V+ + L+ S+ + KA++P PE+ P Q S A S D+
Sbjct: 2167 KQMELEQAVEHIAKLAEASASAAYKADAPEGLAPEDRDKPAHQASETELAAAIGSIINDI 2226
Query: 519 EPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSS 578
E + P P E + QPS E E A +L + +S+
Sbjct: 2227 SGEPENFPAPPPYPGESQTDLQPPAGAQALQPSEEGMETDEAVSGILETEAATESSRPPV 2286
Query: 579 SRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESR 638
+ S+ + +R +S SHS +K + +GR K
Sbjct: 2287 NAPDPSAGPTDTKEARG--NSSETSHSVPEAKGSKEVEVTLVRKDKGRQKT--------- 2335
Query: 639 SRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSS--GQEVATPPVPQLQVCEPKER 696
+RSR + ++K ++P S ++ + + P++ G V P PQ
Sbjct: 2336 ----TRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANEGTTVQHPEAPQ--------- 2382
Query: 697 TSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHL 756
E +++E P +T PQ+ + S +
Sbjct: 2383 -------------------------------------EEKQSEKPHSTPPQSCTSDLSKI 2405
Query: 757 PESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESS- 815
P +E + EE T + P+ P P P+ ++ R +E + S
Sbjct: 2406 PSTENSSQEI-SVEERTPTKASVPPDLPPPPQPAPVDEEPQARFRVHSIIESDPVTPPSD 2464
Query: 816 -------LPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITT 868
LP K+S A+ G+P P + W T Q++P T
Sbjct: 2465 PSIPIPTLPSVTAAKLSPPVASGGIP------HQSPPTKVTEW----ITRQEEPRAQSTP 2514
Query: 869 ESLKSLIPDIK 879
+L PD K
Sbjct: 2515 S--PALPPDTK 2523
Score = 79.7 bits (195), Expect = 2e-14
Identities = 177/893 (19%), Positives = 330/893 (36%), Gaps = 141/893 (15%)
Query: 118 HAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE 177
H + P + E S+ SF+ L +++ LR+R ER S+ E +
Sbjct: 1388 HKSHSPRASALYESSRLSFL---LRDREDKLRERDER----------LSSSLERNKFYSF 1434
Query: 178 GVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAA 237
+ + PD ++ LER + SS EE D R R+++ ++
Sbjct: 1435 ALDKTITPDTKALLERA---------KSLSSSREENWSFLDWDSRFANFRNNKDKE---- 1481
Query: 238 KLSEGSQPAEEEEDQETPS---RNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQK 294
K+ +P PS + ++R D K ++++E+ +EEE++ +E
Sbjct: 1482 KVDSAPRPI--------PSWYMKKKKIRTDSEGKMDDKKEDHKEEEQERQELFASRFLHS 1533
Query: 295 SREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE------AR 348
S F+++ + + ++ +E + R ++ E T S +E +R
Sbjct: 1534 SI-------FEQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSR 1586
Query: 349 KSHLARQQQEKEMKTTSPLEEEEREI-----KSSQGLKEKSKS-----PS--PPRLTEDR 396
L R QQ+++ K P E E++E K+ + E S PS PP +T
Sbjct: 1587 FMELTRMQQKEKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVT 1646
Query: 397 KKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLS--- 453
+++ AL E+T ++ PL+T+E + P EE +P PAP + QL
Sbjct: 1647 LESAPSAL-EKTTGDKTVEAPLVTEEKTVEP----ATVSEEAKPASEPAPAPVEQLEQVD 1701
Query: 454 -PPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADY 512
PP D D ++ P+ + S ++ P P ++ +
Sbjct: 1702 LPPGADPDKEAAMM----------------PAGVEEGSSGDQPPYLDAKPPTPGASFSQA 1745
Query: 513 SAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQ 572
+ D EP+S + K EE K + + + A+ P
Sbjct: 1746 ESNVDPEPDSTQPLSKPAQKSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDL 1805
Query: 573 SADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPL--RSKQRDVAQARTHANPRGRPKMG 630
D + + S RS++ ++ S P+ +S++ D + + +PRG
Sbjct: 1806 EVDPPVAAKDKKPNKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGE---- 1861
Query: 631 SRSTSESRSRSRSRSRSASSNSRKSLS--------PGVSRDSSTSYTETKDPSSGQEVAT 682
++ E + + +R+AS NS L R + S T +
Sbjct: 1862 AQKLLELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVK 1921
Query: 683 PPVPQLQVCEPK-ERTSTSSSSVQAR-RLSQPESAEKHVTQRLQPERGSPKKCEAEEAEP 740
PV Q +V + ER +++V R +P + + + E P AE +P
Sbjct: 1922 EPVEQPRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEP----AETLKP 1977
Query: 741 PAA-TQPQTSETQTSHLPESERIHHTVEEKEEVTMD--TSENRPENDVPEPPMPIADQVS 797
P P++ +T P+ ++ + E K + T T+E P+ V E M +
Sbjct: 1978 PEGWRSPRSQKTAAGGGPQGKKGKN--EPKVDATRPEATTEVGPQIGVKESSM----EPK 2031
Query: 798 NDDRPEGSVEDEEKKESSLPKSFKRKISV-VSATKGVPAGNSDTEGGQPGRKRRWGASTA 856
+ GS + ++K++ K+ V V K P NS ++ G+ R +A
Sbjct: 2032 AAEEEAGSEQKRDRKDAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSA 2091
Query: 857 TTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLK 916
SLK++ + P + + +S +++E + LK
Sbjct: 2092 -------------SLKNVDAAVSPRGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLK 2138
Query: 917 ICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVK 969
+ +E E+E+ P Q++ ++ L EH K
Sbjct: 2139 -----------SDPVDPDKEPEKEDVSASGPSPEATQLAKQMELEQAVEHIAK 2180
Score = 50.4 bits (119), Expect = 1e-05
Identities = 65/322 (20%), Positives = 127/322 (39%), Gaps = 37/322 (11%)
Query: 1034 RTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK------------F 1081
R G +V+ F D++K V Y+ +E A A G K + K +
Sbjct: 539 RYGPVVKVVF--DRLKGMALVLYNEIEYAQAAVKETKGRKIGGNKIKVDFANRESQLAFY 596
Query: 1082 LCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERA 1141
C + + QD D++ L R + + R + P P+ R + + R
Sbjct: 597 HCMEKSGQDIRDFYEMLAERREERRASYDYNQDRTYYESVRTPGTYPEDSRRDYPARGRE 656
Query: 1142 VREQWAERER---EMERRERTRSEREWDRDKVREGPRS---RSRSRDRRRKERAKSKEKK 1195
+W + E + R R++ D + R R R R+R R+ +++
Sbjct: 657 FYSEWETYQGDYYESRYYDDPREYRDYRNDPYEQDIREYSYRQRERERERERFESDRDRD 716
Query: 1196 SEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQ--IVQKEAERA----------- 1242
E++ + + P L + A+P +DS+ + + ++R+
Sbjct: 717 HERRPIERSQSPVHLRRP--QSPGASPSQAERLPSDSERRLYSRSSDRSGSCSSLSPPRY 774
Query: 1243 ERAKEREKRRKEQEEEEQKEREKEAER-ERNRQLEREKRREHSR-ERDRERERERERDRG 1300
E+ + R + E+ KER + ER ER R+L R+++ E + ++ + + +
Sbjct: 775 EKLDKSRLERYTKNEKTDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQ 834
Query: 1301 DRDRDRERDRERGRERDRRDTK 1322
+ D+E +RE+ E+ R K
Sbjct: 835 SSETDQENEREQSPEKPRSCNK 856
Score = 50.4 bits (119), Expect = 1e-05
Identities = 119/600 (19%), Positives = 232/600 (38%), Gaps = 78/600 (13%)
Query: 137 IKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLER--- 193
I++Y +Q+E R+R E+ + E E +H S P S ER
Sbjct: 692 IREYSYRQRERERERERFESDRDRDHERRPIERSQSPVHLRRPQS--PGASPSQAERLPS 749
Query: 194 -PELELSRHSPRKSSSISE------EKGDSD-------DEKPRKGERRSSRVRQARAAKL 239
E L S +S S S EK D +EK K ER R R +L
Sbjct: 750 DSERRLYSRSSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDK-ERTFDPERVERERRL 808
Query: 240 SEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDE-----EEEGDDEG-Q 293
+ +++ D++ + + ++ +T++E E E+ E+ E+ D EG
Sbjct: 809 IRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSREKADKEGIA 868
Query: 294 KSR----EAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARK 349
K+R +L KE+ ++ P E + + + + L++ + SQ E K
Sbjct: 869 KNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQ--KLQVSQTEPAK 926
Query: 350 SHLARQQ-------QEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLV 402
S L++ + +EK + + + E+E +K+ + LK + + + ++ +A
Sbjct: 927 SDLSKLESVRMKVPKEKGLSSHVEVVEKEGRLKARKHLKPEQPADGVSAVDLEKLEARKR 986
Query: 403 ALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTR 462
+ E+ P + K++S ++ S+++ P +L++ +
Sbjct: 987 RFADSNLKAEKQKPEV--KKSSPEMEDARVLSKKQ--PDVSSREVILLREGEAERKPVRK 1042
Query: 463 ELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPES 522
E+L + + L+ ++SP D + E + V S ++ L + + + +E +
Sbjct: 1043 EILKRESKKIKLDRLNTVASPKDCQ-ELASISVGSGSRPSSDLQARLGELAGES-VENQE 1100
Query: 523 DRSAQPLPLK--IEELALAKGITEE---------CLKQPSLEQKEGRRASHTLLPSHRLK 571
+S +P+P K +++L + E L+ + E+K G+ SH++ ++
Sbjct: 1101 VQSKKPIPSKPQLKQLQVLDDQGPEREDVRKNYCSLRDETPERKSGQEKSHSVNTEEKIG 1160
Query: 572 QSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGS 631
D + S S + + + + SP K D + R+ + G+P
Sbjct: 1161 IDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSP--KKDVDEYERRSLVHEVGKPPQDV 1218
Query: 632 RSTS----------------ESRSRSRSRSRSASSNS-RKSLSPGVSRDSSTSYTETKDP 674
S R R+ SR S +S R SP V S+ E +DP
Sbjct: 1219 TDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGGSPSVRHG---SFHEDEDP 1275
Score = 49.3 bits (116), Expect = 2e-05
Identities = 201/1038 (19%), Positives = 366/1038 (35%), Gaps = 170/1038 (16%)
Query: 322 ERPKTRSQEQEVLERGGRFTRSQEEARKS--HLARQQQEKEMKTTS---PLEEEEREIKS 376
+R + R +E+ +R R E +S HL R Q + + P + E R
Sbjct: 699 QRERERERERFESDRDRDHERRPIERSQSPVHLRRPQSPGASPSQAERLPSDSERRLYSR 758
Query: 377 SQGLKEKSKSPSPPRLTE-DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSE 435
S S SPPR + D+ + E+T E P + +E +L +
Sbjct: 759 SSDRSGSCSSLSPPRYEKLDKSRLERYTKNEKTDKERTFDPERVERER-------RLIRK 811
Query: 436 EEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKV 495
E++E TD R+ + SPS +E+ E
Sbjct: 812 EKVEK--------------DKTDKQKRK--------------GKVHSPSSQSSETDQENE 843
Query: 496 PEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPL-KIEELALAKGITE--ECLKQPSL 552
E+S PE RS L K ++ +AK E C+ +
Sbjct: 844 REQS--------------------PEKPRSCNKLSREKADKEGIAKNRLELMPCVVLTRV 883
Query: 553 EQKEGRRASHTLLPSHRLKQSADSSSSRSS---------------SSSSSSSRSRSRSPD 597
++KEG+ HT P +LK D+ + +SS S S R + P
Sbjct: 884 KEKEGKVIDHT--PVEKLKAKLDNDTVKSSALDQKLQVSQTEPAKSDLSKLESVRMKVPK 941
Query: 598 SSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLS 657
G SH + K+ + +AR H P +P G + + +R R + S+ +
Sbjct: 942 EKGLSSHVEVVEKEGRL-KARKHLKPE-QPADGVSAVDLEKLEARKRRFADSNLKAEKQK 999
Query: 658 PGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEK 717
P V + S P+++ + SS + L + E+ K
Sbjct: 1000 PEVKKSS---------------------PEMEDARVLSKKQPDVSSREVILLREGEAERK 1038
Query: 718 HVTQR-LQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDT 776
V + L+ E K P Q S + S S + + E +++
Sbjct: 1039 PVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAGESVEN 1098
Query: 777 SENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSL------PKSFKRKISVVSAT 830
E + + +P P QV +D PE ED K SL KS + K V+
Sbjct: 1099 QEVQSKKPIPSKPQLKQLQVLDDQGPER--EDVRKNYCSLRDETPERKSGQEKSHSVNTE 1156
Query: 831 KGVPAGNSDTEG-----GQPGRKRRWGASTATTQK--KPSISITTESLKSLIPDI-KPLA 882
+ + T+ Q RK++ A ++K P + +SL+ ++ KP
Sbjct: 1157 EKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLVHEVGKP-- 1214
Query: 883 GQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEK 942
Q+ DDS S+ + + D K + R+ Q + + + G
Sbjct: 1215 PQDV-----TDDSPPSKKKRMDHVDFDICTKRERNYRSSRQ-ISEDSERTGGSPSVRHGS 1268
Query: 943 EPEAEPPVPPQVSVEVALPPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQV 1002
E E P+ + V P + +V L +I+ ++ + D R Q+
Sbjct: 1269 FHEDEDPIGSPRLLSVKGSPKVDEKV--------LPYSNITVREESLKFNPYDSSRREQM 1320
Query: 1003 PSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEA 1062
+ K+S + L R Q+K+ GR + I K S + +E
Sbjct: 1321 ADMAKIKLSVLNSEDELNR--WDSQMKQDAGRFDVSFPNS--IIKRDSLRKRSVRDLEPG 1376
Query: 1063 VATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPP- 1121
+ + +P+ + E L + LL DR + + ++ + L
Sbjct: 1377 EVPSDSDEDGEHKSHSPR--ASALYESSRLSF---LLRDREDKLRERDERLSSSLERNKF 1431
Query: 1122 -----PPPVQPPQHPRAEQREQERAVREQ-WAEREREMERRERTRSEREWDRDKVREGPR 1175
+ P E+ + + RE+ W+ + + R R+ ++ ++ V PR
Sbjct: 1432 YSFALDKTITPDTKALLERAKSLSSSREENWSFLDWD-SRFANFRNNKDKEK--VDSAPR 1488
Query: 1176 SRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIV 1235
+++K R S+ K +KKE +EE + +LF S I
Sbjct: 1489 PIPSWYMKKKKIRTDSEGKMDDKKEDHKEEEQER--QELFASR----------FLHSSIF 1536
Query: 1236 QKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSR--ERDRERER 1293
+++++R + + +E+ ++ E ++ HSR E R +++
Sbjct: 1537 EQDSKRLQHLERKEEDSDFISGRIYGKQTSEGANSTTDSIQEPVVLFHSRFMELTRMQQK 1596
Query: 1294 ERERDRGDRDRDRERDRE 1311
E+E+D+ ++ +++ D E
Sbjct: 1597 EKEKDQKPKEVEKQEDTE 1614
Score = 46.6 bits (109), Expect = 2e-04
Identities = 42/99 (42%), Positives = 50/99 (50%), Gaps = 17/99 (17%)
Query: 591 SRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASS 650
SRSRSP SS SR+ SP QR +QA RP + S S S SRSRS S+ S
Sbjct: 240 SRSRSPHSSQSRNQSP----QRLASQA-------SRP-----TRSPSGSGSRSRSSSSDS 283
Query: 651 NSRKSLSPGVSRDSSTSYTETKDPSSGQEVATP-PVPQL 688
S S + S DSS+S ++ S Q A P P QL
Sbjct: 284 ISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQL 322
Score = 46.2 bits (108), Expect = 2e-04
Identities = 251/1298 (19%), Positives = 470/1298 (36%), Gaps = 221/1298 (17%)
Query: 99 VKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQ---------ELLR 149
V+R + + E ++K T + ++ SQ+S Q E++Q +L R
Sbjct: 802 VERERRLIRKEKVEKDKTDKQ--KRKGKVHSPSSQSSETDQENEREQSPEKPRSCNKLSR 859
Query: 150 QRLEREAREAAELEEASA-------ESEDEMIHPEGV----ASLLPPDFQSSLERPELEL 198
++ ++E LE E E ++I V A L +SS +L++
Sbjct: 860 EKADKEGIAKNRLELMPCVVLTRVKEKEGKVIDHTPVEKLKAKLDNDTVKSSALDQKLQV 919
Query: 199 SRHSPRKSS---------SISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAE-- 247
S+ P KS + +EKG S + + E R +A K + QPA+
Sbjct: 920 SQTEPAKSDLSKLESVRMKVPKEKGLSSHVEVVEKEGR------LKARKHLKPEQPADGV 973
Query: 248 EEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQ---KSREAPILKEF 304
D E R AD NLK E+++ E ++ + E+ + Q SRE +L+E
Sbjct: 974 SAVDLEKLEARKRRFADSNLKAEKQKPEVKKSSPEMEDARVLSKKQPDVSSREVILLREG 1033
Query: 305 KEEGE----EIPRVKPEEMMDER------PKTRSQEQEVLERGGRFTRSQEEARKSHLAR 354
+ E + EI + + +++ +R PK + + G S +AR LA
Sbjct: 1034 EAERKPVRKEILKRESKKIKLDRLNTVASPKDCQELASISVGSGSRPSSDLQARLGELAG 1093
Query: 355 QQQE-KEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLV-ALPEQTASEE 412
+ E +E+++ P+ + ++K Q L ++ P R + SL PE+ + +E
Sbjct: 1094 ESVENQEVQSKKPIPSKP-QLKQLQVLDDQG----PEREDVRKNYCSLRDETPERKSGQE 1148
Query: 413 ETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSP----PNTDADTRELLVSQ 468
++ ++ H Q + ++ + + I S P D D E
Sbjct: 1149 KSHSVNTEEKIGIDIDHTQSYRKQMEQSRRKQQMEMEIAKSEKFGSPKKDVDEYERRSLV 1208
Query: 469 HTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPL-VQKSTLADYSAQKDLEPESDRSA- 526
H V P D +SP K + + +Y + + + +S+R+
Sbjct: 1209 HEVG--------KPPQDVTDDSPPSKKKRMDHVDFDICTKRERNYRSSRQISEDSERTGG 1260
Query: 527 -----------QPLPLKIEELALAKG---ITEECLKQPSLEQKEGRRASHTLLPSHRLKQ 572
P+ L KG + E+ L ++ +E S R +Q
Sbjct: 1261 SPSVRHGSFHEDEDPIGSPRLLSVKGSPKVDEKVLPYSNITVRE-ESLKFNPYDSSRREQ 1319
Query: 573 SADSSSSRSSSSSSSSSRSR--SRSPDSSGSRSHS-PLRSKQRDVAQART--HANPRGRP 627
AD + + S +S +R S+ +G S P +RD + R+ P P
Sbjct: 1320 MADMAKIKLSVLNSEDELNRWDSQMKQDAGRFDVSFPNSIIKRDSLRKRSVRDLEPGEVP 1379
Query: 628 KMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQ 687
S S+ +S S AS+ S + RD
Sbjct: 1380 -----SDSDEDGEHKSHSPRASALYESSRLSFLLRDREDKL------------------- 1415
Query: 688 LQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQ 747
+ER SSS++ + + +K +T K E A+ ++++
Sbjct: 1416 ------RERDERLSSSLERNKFYS-FALDKTITP--------DTKALLERAKSLSSSR-- 1458
Query: 748 TSETQTSHLPESERIHHTVEEKEEVTMDTSENR-PENDVPEPPMPIADQVSNDDRPEGSV 806
E S L R + K++ +D++ P + + + + DD+ E
Sbjct: 1459 --EENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKMDDKKEDHK 1516
Query: 807 EDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISI 866
E+E++++ F +K + E R +G T+ +
Sbjct: 1517 EEEQERQELFASRFLHSSIFEQDSKRLQHLERKEEDSDFISGRIYGKQTSE-----GANS 1571
Query: 867 TTESLKSLIPDIKPLAGQEAVVDLHA---DDSRISEDETERNGDDGTHDKGLKICRTVTQ 923
TT+S+ QE VV H+ + +R+ + E E++ + +
Sbjct: 1572 TTDSI------------QEPVVLFHSRFMELTRMQQKEKEKD-------------QKPKE 1606
Query: 924 VVPAEGQENGQREEEEEEKEPEAEPPVPPQV---SVEVALPPPAEHEVKKVTLGDTLTRR 980
V E EN + E + ++E PP V SV V A ++K T T+
Sbjct: 1607 VEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLESAPSALEKTTGDKTVEAP 1666
Query: 981 SISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVE 1040
++++K+ T+ + + A P+P + QL+++ G
Sbjct: 1667 LVTEEKTVEPATVSEEAKPASEPAPA-----------------PVEQLEQVDLPPGA--- 1706
Query: 1041 EAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLV 1100
D K + E + + K P F A+ E D + L
Sbjct: 1707 -----DPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQPL-- 1759
Query: 1101 DRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAE-------QREQERAVREQWAEREREM 1153
+P++ K+EE P+ P +P + +AE ++ V A ++++
Sbjct: 1760 SKPAQ-KSEEANEPKAEKPDATADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKP 1818
Query: 1154 ERRERTRSEREWDRDKVREGPRSRSRSR-DRRRKERAKSKEKKSEKKEKAQEEPPAKLLD 1212
+ +R+++ + + E P +R R DR + +R+ S +++K + + E A+ +
Sbjct: 1819 NKSKRSKTPVQAAAVSIVEKPVTRKSERIDREKLKRSNSPRGEAQKLLELKME--AEKIT 1876
Query: 1213 DLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAK--EREKRRKEQEEEEQKEREKEAERE 1270
K AA + P ++ R+ A + E R +E EQ R
Sbjct: 1877 RTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQ-------PRV 1929
Query: 1271 RNRQLEREKRREHSRERDRERER-ERERDRGDRDRDRE 1307
++LERE + + R R + R R D + + E
Sbjct: 1930 TRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENE 1967
Score = 39.3 bits (90), Expect = 0.026
Identities = 39/124 (31%), Positives = 51/124 (41%), Gaps = 31/124 (25%)
Query: 581 SSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSR 640
S S S SS+SR++SP S++ P RS S
Sbjct: 240 SRSRSPHSSQSRNQSPQRLASQASRPTRSP----------------------------SG 271
Query: 641 SRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEV--ATPPVPQLQVCEPKERTS 698
S SRSRS+SS+S S S S DSS S + + D S + V A P P Q+ E+
Sbjct: 272 SGSRSRSSSSDSISS-SSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDE 330
Query: 699 TSSS 702
S
Sbjct: 331 PRKS 334
Score = 35.8 bits (81), Expect = 0.28
Identities = 46/176 (26%), Positives = 61/176 (34%), Gaps = 31/176 (17%)
Query: 512 YSAQKDLEPESDRSAQPL--PLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHR 569
Y A + P + P P E+ L + + + + GRR H
Sbjct: 183 YYASRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERNY--QHS 240
Query: 570 LKQSADSSSSRSSSSSSSSSRSR--SRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRP 627
+S SS SR+ S +S++ +RSP SGSRS S
Sbjct: 241 RSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRS---------------------- 278
Query: 628 KMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATP 683
S S S S S S S S SS+S SP S S+ T S E P
Sbjct: 279 ---SSSDSISSSSSTSSDSSDSSSSSSDDSPARSVQSAAVPAPTSQLLSSLEKDEP 331
Score = 31.6 bits (70), Expect = 5.4
Identities = 47/215 (21%), Positives = 77/215 (35%), Gaps = 26/215 (12%)
Query: 1105 ETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAER---------EREMER 1155
E K E + I R ++ P+ R + R VR +A + +E+
Sbjct: 1867 ELKMEAEKITRTASKNSAADLEHPEPSLPLSRTRRRNVRSVYATMGDHENRSPVKEPVEQ 1926
Query: 1156 RERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLF 1215
TR E + + P + R R + + RA +E+ K+ +PP
Sbjct: 1927 PRVTRKRLERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRS 1986
Query: 1216 RKTKAAPCIYWL-----PLTDSQIVQKEAERAER--AKEREKRRKEQEEE---EQKEREK 1265
+KT A P D+ + E + KE K EEE EQK K
Sbjct: 1987 QKTAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRK 2046
Query: 1266 EAERERN-------RQLEREKRREHSRERDRERER 1293
+A ++N +E++ E + + R R R
Sbjct: 2047 DAGTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSR 2081
Score = 31.2 bits (69), Expect = 7.0
Identities = 32/110 (29%), Positives = 46/110 (41%), Gaps = 13/110 (11%)
Query: 389 PPRLTEDR-KKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPP 447
P +LT + AS V LP +T + + PPP + PP P + S + +P P PP
Sbjct: 3317 PAQLTHTQFPAASSVGLPSRTKTAAQGPPP---EGEPLQPPQP-VQSTQPAQPAP-PCPP 3371
Query: 448 VLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPE 497
QL P ++ VSQ G+ P+ PA + PE
Sbjct: 3372 --SQLGQPGQPPSSKMPQVSQEAKGTQTGVEQPRLPA-----GPANRPPE 3414
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 85.1 bits (209), Expect = 4e-16
Identities = 57/212 (26%), Positives = 96/212 (45%), Gaps = 18/212 (8%)
Query: 1130 HPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERA 1189
H R+ R + + + + R+RS R R + + RS+SRSR ++ K R+
Sbjct: 191 HSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRS-RSGSRSRSKSRSRSQSRSRSKKEKSRS 249
Query: 1190 KSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKERE 1249
SKEK + A + +K D K + ++ V K R+ + +
Sbjct: 250 PSKEKSRSRSHSAGKSR-SKSKDQAEEK-----------IQNNDNVGKPKSRSPSRHKSK 297
Query: 1250 KRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERD 1309
+ + + +E + E EK R R E+ R+ SR R + R R R R + +D
Sbjct: 298 SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRS-----KSKD 352
Query: 1310 RERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
+ +GR+R R +++ SRSRS+S R RG +R
Sbjct: 353 KRKGRKRSREESRSRSRSRSKSERSRKRGSKR 384
Score = 73.2 bits (178), Expect = 2e-12
Identities = 75/286 (26%), Positives = 124/286 (43%), Gaps = 14/286 (4%)
Query: 589 SRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSA 648
S SRSRS S SRS +S+ R + +H+ R R + GSRS S+SRSRS+SRSRS
Sbjct: 184 SYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSK 243
Query: 649 SSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQL-QVCEPKERTSTSSSSVQAR 707
SR SP + S S++ K S ++ A + V +PK R S S +++
Sbjct: 244 KEKSR---SPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSR---SPSRHKSK 297
Query: 708 RLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVE 767
S+ S E+ V + +RGS + ++E S ++ S + +
Sbjct: 298 SKSRSRSQERRVEEE---KRGSVSRGRSQEKS--LRQSRSRSRSKGGSRSRSRSRSKSKD 352
Query: 768 EKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVV 827
+++ E+R + + S D GS + ++K+++ +S SV
Sbjct: 353 KRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVS 412
Query: 828 SATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKS 873
+ + +S EG G G + T + S S + +L S
Sbjct: 413 KEREHAKSESSQREG--RGESENAGTNQETRSRSRSNSKSKPNLPS 456
Score = 72.8 bits (177), Expect = 2e-12
Identities = 67/255 (26%), Positives = 103/255 (40%), Gaps = 27/255 (10%)
Query: 482 SPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKG 541
S S ++++S + E+S P +KS +SA K D++ E++
Sbjct: 230 SKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAE-------EKIQNNDN 282
Query: 542 ITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGS 601
+ + + PS + + + S + R+++ S SR S S +SRSRS GS
Sbjct: 283 VGKPKSRSPSRHKSKSKSRSRS--QERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGS 340
Query: 602 RSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVS 661
RS S RSK +D + R RS ESRSRSRSRS+S S R S +
Sbjct: 341 RSRSRSRSKSKDKRKGR------------KRSREESRSRSRSRSKSERSRKRGSKRDSKA 388
Query: 662 RDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQ 721
S E D S + P V + +E + SS + R S+ +
Sbjct: 389 GSSKKKKKEDTDRSQSRS------PSRSVSKEREHAKSESSQREGRGESENAGTNQETRS 442
Query: 722 RLQPERGSPKKCEAE 736
R + S +E
Sbjct: 443 RSRSNSKSKPNLPSE 457
Score = 71.6 bits (174), Expect = 5e-12
Identities = 86/339 (25%), Positives = 130/339 (38%), Gaps = 65/339 (19%)
Query: 552 LEQKEG--RRASHTLLPSHRLKQSAD----SSSSRSSSSSSSSSRSRSRSPDSSGSRSHS 605
+E K G RR S++ SH +S S SRS SS SS S+SRSRS S SRS S
Sbjct: 173 VEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKS 232
Query: 606 PLRSKQR-------------DVAQARTHANPRGRPK---------------------MGS 631
RS+ R + +++R+H+ + R K S
Sbjct: 233 RSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPS 292
Query: 632 RSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVC 691
R S+S+SRSRS+ R R S+S G S++ S + ++ S G +
Sbjct: 293 RHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKD 352
Query: 692 EPKER-TSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSE 750
+ K R S S ++R S+ E + K ++R + GS KK + E+ + + P S
Sbjct: 353 KRKGRKRSREESRSRSRSRSKSERSRKRGSKR-DSKAGSSKKKKKEDTDRSQSRSPSRSV 411
Query: 751 TQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEE 810
++ ER H E + SEN N
Sbjct: 412 SK-------EREHAKSESSQREGRGESENAGTN----------------QETRSRSRSNS 448
Query: 811 KKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKR 849
K + +LP + + S T+ S + P R R
Sbjct: 449 KSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSR 487
Score = 68.2 bits (165), Expect = 5e-11
Identities = 58/223 (26%), Positives = 93/223 (41%), Gaps = 24/223 (10%)
Query: 1119 PPPPPPVQPPQHPRAEQREQERAVREQW---AEREREMERRERTRSEREWDRDKVREGPR 1175
P P + ++ R QER V E+ R R E+ R R + R R
Sbjct: 286 PKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSR 345
Query: 1176 SRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIV 1235
SRS+S+D+R+ + +E +S + +++ E K R +KA
Sbjct: 346 SRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSK--RDSKA-----------GSSK 392
Query: 1236 QKEAERAERAKEREKRR---KEQE----EEEQKEREKEAERERNRQLEREKRREHSRERD 1288
+K+ E +R++ R R KE+E E Q+E E+E Q R + R +S+ +
Sbjct: 393 KKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKP 452
Query: 1289 RERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRS 1331
R R + + R R + R R R ++ SRS SRS
Sbjct: 453 NLPSESRSRSK-SASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494
Score = 67.0 bits (162), Expect = 1e-10
Identities = 59/209 (28%), Positives = 86/209 (41%), Gaps = 33/209 (15%)
Query: 1136 REQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR-KERAKSKEK 1194
R + R + R R R R R RSRSRS R R K R++S+ +
Sbjct: 180 RRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSR 239
Query: 1195 KSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKE 1254
KKEK++ P+K +K R+ A + + K+
Sbjct: 240 SRSKKEKSRS--PSK--------------------------EKSRSRSHSAGKSRSKSKD 271
Query: 1255 QEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGD--RDRDRERDRER 1312
Q EE+ + + + ++R R K + SR R +ER E E+ RG R R +E+ +
Sbjct: 272 QAEEKIQNNDNVG-KPKSRSPSRHKSKSKSRSRSQERRVEEEK-RGSVSRGRSQEKSLRQ 329
Query: 1313 GRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
R R R SRSRSRS R GR+
Sbjct: 330 SRSRSRSKGGSRSRSRSRSKSKDKRKGRK 358
Score = 63.2 bits (152), Expect = 2e-09
Identities = 87/361 (24%), Positives = 142/361 (39%), Gaps = 73/361 (20%)
Query: 323 RPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKE 382
R +RS+ + R R +RS+ + KS ++ + + S + R S+ KE
Sbjct: 189 RSHSRSRSRS---RHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKE 245
Query: 383 KSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPME 442
KS+SPS E + S A ++ S+++ +EE+I+ +
Sbjct: 246 KSRSPSK----EKSRSRSHSAGKSRSKSKDQ--------------------AEEKIQNND 281
Query: 443 GPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLP 502
P SP S+H S S +++ S +V EE
Sbjct: 282 NVGKPK--SRSP------------SRH-----------KSKSKSRSRSQERRVEEEK--- 313
Query: 503 LVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASH 562
+ S S +K L RS + + +K + ++ S E+ R S
Sbjct: 314 --RGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSR 371
Query: 563 TLLPSHRLKQSADSSSSRSSSSSSS--SSRSRSRSPDSSGS--RSHSPLRSKQRD----- 613
+ R + S S + SS + RS+SRSP S S R H+ S QR+
Sbjct: 372 SKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGES 431
Query: 614 -------VAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666
++R+ +N + +P + S S S S+S S++RSRS S + S SP SR S
Sbjct: 432 ENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSH 491
Query: 667 S 667
S
Sbjct: 492 S 492
Score = 62.8 bits (151), Expect = 2e-09
Identities = 47/210 (22%), Positives = 92/210 (43%), Gaps = 31/210 (14%)
Query: 1125 VQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDR- 1183
V P+ + + + R + ER E E+R R ++ + RSRS+ R
Sbjct: 283 VGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRS 342
Query: 1184 RRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAE 1243
R + R+KSK+K+ +K +E S+ + ++E
Sbjct: 343 RSRSRSKSKDKRKGRKRSREE---------------------------SRSRSRSRSKSE 375
Query: 1244 RAKEREKRRKEQEEEEQKEREKEAERERNRQLER--EKRREHSRERDRERERERERDRGD 1301
R+++R +R + +K+++++ +R ++R R K REH++ +RE E +
Sbjct: 376 RSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAG 435
Query: 1302 RDRDRERDRERGRERDRRDTKRHSRSRSRS 1331
+++ R R R + + + SRSRS+S
Sbjct: 436 TNQE-TRSRSRSNSKSKPNLPSESRSRSKS 464
Score = 45.4 bits (106), Expect = 4e-04
Identities = 25/101 (24%), Positives = 43/101 (42%), Gaps = 9/101 (8%)
Query: 1234 IVQKEAERAERAKEREK---RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRE 1290
+ K R R+ R + R + + +K R + + + R + R SR R +
Sbjct: 173 VEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKS 232
Query: 1291 RERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRS 1331
R R + R R +++ R +E+ R R HS +SRS
Sbjct: 233 RSRSQSRSRSKKEKSRSPSKEKSRSRS------HSAGKSRS 267
Score = 45.4 bits (106), Expect = 4e-04
Identities = 55/247 (22%), Positives = 100/247 (40%), Gaps = 19/247 (7%)
Query: 199 SRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSR- 257
SRHS + S K S K R R SR R ++ S+ ++E +PS+
Sbjct: 198 SRHSRKSRSRSGSSK--SSHSKSRSRSRSGSRSRSKSRSRSQSRSR--SKKEKSRSPSKE 253
Query: 258 NLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPE 317
R R+ K+ + +++ EE+ + + G + + + + +E R E
Sbjct: 254 KSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQE--RRVEE 311
Query: 318 EMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSS 377
E + RSQE+ + + R +RS+ +R +R + + + K EE R S
Sbjct: 312 EKRGSVSRGRSQEKSLRQSRSR-SRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRS 370
Query: 378 QGLKEKSKSPSPPRLTEDRKKASLVALPEQT-ASEEETPPPLLTKEASSPPPHPQLHSEE 436
+ E+S+ R + + +S E T S+ +P ++KE H++
Sbjct: 371 RSKSERSRKRGSKR--DSKAGSSKKKKKEDTDRSQSRSPSRSVSKERE--------HAKS 420
Query: 437 EIEPMEG 443
E EG
Sbjct: 421 ESSQREG 427
Score = 37.0 bits (84), Expect = 0.13
Identities = 41/180 (22%), Positives = 73/180 (40%), Gaps = 16/180 (8%)
Query: 192 ERPELELSRHSPR-KSSSISEEKGDSDDEKPRKGERRS---SRVRQARAAKLSEGSQPAE 247
+ L SR R K S S + S + RKG +RS SR R +R+ SE S+
Sbjct: 323 QEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSR-SRSRSKSERSRKRG 381
Query: 248 EEEDQETPSRNLRVRADRN-LKTEEEEEEEEEEEEDDEEEEGDDEGQ-KSREAPILKEFK 305
+ D + S + + D + ++ +E E + E EG+ +S A +E +
Sbjct: 382 SKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETR 441
Query: 306 EEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTS 365
+ KP + R +++S + TRS+ ++R +R ++ S
Sbjct: 442 SRSRSNSKSKPNLPSESRSRSKSASK---------TRSRSKSRSRSASRSPSRSRSRSHS 492
Score = 33.1 bits (74), Expect = 1.8
Identities = 33/127 (25%), Positives = 47/127 (37%), Gaps = 3/127 (2%)
Query: 1206 PPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREK 1265
PP + L + ++ C W L D E A+ K R K E + ++
Sbjct: 98 PPTRTEYRLIVENLSSRCS-WQDLKDYMRQAGEVTYADAHKGR-KNEGVIEFVSYSDMKR 155
Query: 1266 EAERERNRQLEREKRREHSRERDRERERERERDRG-DRDRDRERDRERGRERDRRDTKRH 1324
E+ ++ K R + R R R R R R R R + R R H
Sbjct: 156 ALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSH 215
Query: 1325 SRSRSRS 1331
S+SRSRS
Sbjct: 216 SKSRSRS 222
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 85.1 bits (209), Expect = 4e-16
Identities = 116/473 (24%), Positives = 178/473 (37%), Gaps = 49/473 (10%)
Query: 325 KTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKS 384
K + LE G +E + LA + SP E ++ K+ +
Sbjct: 2339 KAKGDRAATLEEGN----PTDEVPSTPLALEPSSTPGSKKSPPEPVDKRAKAPKARPAPP 2394
Query: 385 K-SPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEG 443
+ SP+PP T LP S P PL+T A+ P P +EE +G
Sbjct: 2395 QPSPAPPAFTSCPAPEPFAELPAPATSL--APAPLITMPATRPKPKKARAAEES--GAKG 2450
Query: 444 PAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEE--SVL 501
P P + ELLV + S + + E P +E S+L
Sbjct: 2451 PRRP-----------GEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGAGGWQEPKSLL 2499
Query: 502 PLVQKSTLADYSAQKDLEPES---DRSAQPLP-LKIEELALAKGITEECLKQPSLEQKEG 557
L A S K P++ D + +P P L E+ K + +Q E+ E
Sbjct: 2500 SLGSYPPAAGSSEPKAPWPKATDGDLAQEPGPGLTFEDSGNPKSPDKAQAEQDGAEESES 2559
Query: 558 RRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQA 617
S+ SS S SSSSSSSSS S + + + R+ + A
Sbjct: 2560 --------------SSSSSSGSSSSSSSSSSSGSETEGEEEGDKNGDGGCGTGGRNCSAA 2605
Query: 618 RTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSG 677
+ A S S+S S S S S S S+SS+S S S S SS+S + + SS
Sbjct: 2606 SSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2665
Query: 678 QEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGSPKK---CE 734
++ + C + + + ++ + + + P A K + +P SP K
Sbjct: 2666 SSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPTKATKQ-AGKARPSAHSPGKKTPAP 2724
Query: 735 AEEAEPPAATQPQTSETQT---SHLPESERIH--HTVEEKEEVTMDTSENRPE 782
+A PP TQP + Q S + E +H T E + + + ENRP+
Sbjct: 2725 QPQAPPPQPTQPLQPKAQAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPK 2777
Score = 40.4 bits (93), Expect = 0.012
Identities = 38/130 (29%), Positives = 50/130 (38%), Gaps = 28/130 (21%)
Query: 1114 PRPLHPPPPPPVQPPQHPRA----------EQREQERAVR-------EQWAER----ERE 1152
P PL PPP PP PP P A EQ + R V E + ER +
Sbjct: 332 PSPLPPPPAPPKGPPAPPAATPAGVYTVFREQGREHRVVAPTFVPSVEAFDERPGPIQIA 391
Query: 1153 MERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLD 1212
+ R+ ERE R V + P R DR R K+ +S K+ + P
Sbjct: 392 SQARDARAREREAGRPGVLQAPPGSPRPLDRPEGLREKNSVIRSLKRPPPADAPTV---- 447
Query: 1213 DLFRKTKAAP 1222
R T+A+P
Sbjct: 448 ---RATRASP 454
Score = 34.7 bits (78), Expect = 0.63
Identities = 45/169 (26%), Positives = 62/169 (36%), Gaps = 20/169 (11%)
Query: 376 SSQGLKEKSKSPSP-PRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHS 434
SS SP P P +T + V + E+E P P + PP +P
Sbjct: 1028 SSHPTSPPPASPPPTPGITRKEEAPENVVEKKDLELEKEAPSPFQALFSDIPPRYP---- 1083
Query: 435 EEEIEPMEGPAPPVLIQLSPPNTDADTREL-----LVSQHTVQLVGGLSPLSSP---SDT 486
+ + P G P L+Q P AD L L + +L LSP P S +
Sbjct: 1084 FQALPPHYGRPYPFLLQ---PTAAADADGLAPDVPLPADGPERL--ALSPEDKPIRLSPS 1138
Query: 487 KAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEE 535
K P + PEE PL ++ A+ + E PLPL E
Sbjct: 1139 KITEPLREGPEEE--PLAEREVKAEVEDMDEGPTELPPLESPLPLPAAE 1185
Score = 34.3 bits (77), Expect = 0.83
Identities = 36/146 (24%), Positives = 59/146 (40%), Gaps = 18/146 (12%)
Query: 221 PRKGERRSSRVRQARAAKLSEGSQP----AEEEEDQETPSRNLRVRADRNLKTEEEEEEE 276
P+ +R + R + + QP E E + + S + D++ +EEE+EEE
Sbjct: 1775 PKLTKRGLAAPRTLKPKPATSRKQPFCLLLREAEARSSFSDSSEESFDQDESSEEEDEEE 1834
Query: 277 EEEEEDDEEEEGDDEGQKSREAP---------ILKEFKEEGEEIPRVKPE---EMMDERP 324
E EEED+ G G + R +L F P V P ++ +
Sbjct: 1835 ELEEEDEASGGGYRLGARERALSPGLEESGLGLLARFAASALPSPTVGPSLSVVQLEAKQ 1894
Query: 325 KTRSQE--QEVLERGGRFTRSQEEAR 348
K R +E Q +L +T S+ E +
Sbjct: 1895 KARKKEERQSLLGTEFEYTDSESEVK 1920
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 84.7 bits (208), Expect = 5e-16
Identities = 115/516 (22%), Positives = 217/516 (42%), Gaps = 53/516 (10%)
Query: 58 KMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGAL---MLENLQKH 114
+ A+L E K +A+R + A +R L + V+ K +L + + ++H
Sbjct: 295 RYAKLTEAAEQNK--EAIRSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIEERH 352
Query: 115 STPHAAFQPN-SQIGEEMSQNSF-IKQYLEKQQELLRQRLEREAREAAELEEASAESEDE 172
+ +++Q Q+ E+ + + ++L + Q+LL ++ + AA + E
Sbjct: 353 NHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRF 412
Query: 173 MIHPEGVASLL-----PPDFQSSLERPELELSRHSPRKS--SSISEEKGDSDDEKPRKGE 225
+ L P S +++P++E + + I EE D++ E
Sbjct: 413 STFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM--E 470
Query: 226 RRSSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRN--------LKTEEEEEEEE 277
+ + + A + E + A EE+++E + V A ++ +K EE E+EEE
Sbjct: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
Query: 278 EEEEDDEEEEGDDEGQKSREAPILKE---FKEEGEEIPRVKPEEMMDERPKTRSQEQEVL 334
E +E++EEE+ + ++ E KE KEEGE+ E E + + +E++V
Sbjct: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVE 589
Query: 335 ERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTE 394
E+ +E + + + ++ K SP+EE+ + ++EK KSP P E
Sbjct: 590 EKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 649
Query: 395 DRKKASLVALP-EQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEG---PAPPVLI 450
++ K+ + P E+ + P+ K S P P ++ + E +G +
Sbjct: 650 EKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEV 709
Query: 451 QLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLA 510
+ +P + +E P P KAESP V EE+V +V +
Sbjct: 710 KEAPKEEKVEKKE-------------EKPKDVPEKKKAESP---VKEEAVAEVVTITK-- 751
Query: 511 DYSAQKDLEPESDRSAQPLPL-KIEELALAKGITEE 545
S + LE E+ +PL K +E A +G +EE
Sbjct: 752 --SVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEE 785
Score = 60.8 bits (146), Expect = 8e-09
Identities = 155/791 (19%), Positives = 286/791 (36%), Gaps = 98/791 (12%)
Query: 186 DFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQP 245
D++ S + +L + R + I + K + E ++ R +QA A+L +
Sbjct: 93 DYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQASHAQLGDAY-- 150
Query: 246 AEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSRE--APILKE 303
DQE + + K + + + + EE+ +E +E + R+ ++
Sbjct: 151 -----DQEIRELRATLEMVNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAAIRA 205
Query: 304 FKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKT 363
+++ EE VK E +D+ K +S + EV F RS E + L Q Q +
Sbjct: 206 LRKDIEEASLVKVE--LDK--KVQSLQDEVA-----FLRSNHEEEVADLLAQIQASHITV 256
Query: 364 TSPLEEEEREIKSSQGLKE-----KSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPL 418
++ + S LKE +S S E+ K L E +E +
Sbjct: 257 E---RKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEA---I 310
Query: 419 LTKEASSPPPHPQLHSEE-EIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGL 477
+ + QL S+ E+E + G + QLS + +L Q T+Q +
Sbjct: 311 RSAKEEIAEYRRQLQSKSIELESVRGTKESLERQLSDIE-ERHNHDLSSYQDTIQQLE-- 367
Query: 478 SPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQ-------PLP 530
+ TK E + +L + + + +K LE E R + PL
Sbjct: 368 ---NELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLY 424
Query: 531 LKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSR 590
+ ++ I + ++ P L K + ++ +++ ++ + +
Sbjct: 425 THRPPITISSKIQKPKVEAPKL--KVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAV 482
Query: 591 SRSRSPDSSGSRSHSPLRSKQRDVAQARTHAN---PRGRPKMGSRSTSESRSRSRSRSRS 647
S + +++ +VA ++ P + + G + E +
Sbjct: 483 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 648 ASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPK------ERTSTSS 701
A S+ + G S +S E + G+ A + + E K E +T
Sbjct: 543 AKSDQAEE---GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE 599
Query: 702 SSVQARRLSQPESAEKHVTQRLQPERGS---PKKCEAEEAEPPAATQPQTSETQTSHLPE 758
V ++ +PE A+ V + E+G PK E+ + P P E S +P+
Sbjct: 600 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSP-VEEKGKSPVPK 658
Query: 759 SERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKE-SSLP 817
S VEEK + + S + P P P+ + S + +G ++EE+KE P
Sbjct: 659 SP-----VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP 713
Query: 818 KSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPD 877
K K V + P + + + K A T K + + E+ + +
Sbjct: 714 KEEK-----VEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKE----E 764
Query: 878 IKPLAGQEAVVDLHADDSRISEDETERNGDDG-----THDKGLKICRTVTQVVPAEGQEN 932
KPL E E E+ G +G DKG K R + + G+
Sbjct: 765 GKPLQ---------------QEKEKEKAGGEGGSEEEGSDKGAKGSR--KEDIAVNGEVE 807
Query: 933 GQREEEEEEKE 943
G+ E E+E KE
Sbjct: 808 GKEEVEQETKE 818
Score = 60.1 bits (144), Expect = 1e-08
Identities = 140/747 (18%), Positives = 277/747 (37%), Gaps = 81/747 (10%)
Query: 127 IGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPD 186
+ E +Q +LE+ L++R E EAR + E A + +L
Sbjct: 164 VNHEKAQVQLDSDHLEEDIHRLKERFEEEARLRDDTEAA-------------IRALRKDI 210
Query: 187 FQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPA 246
++SL + EL+ +K S+ +E + E + + Q +A+ ++
Sbjct: 211 EEASLVKVELD------KKVQSLQDEVAFL---RSNHEEEVADLLAQIQASHIT-----V 256
Query: 247 EEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKE 306
E ++ +T ++ T +E + E D+ +E K R A L E E
Sbjct: 257 ERKDYLKT-----------DISTALKEIRSQLESHSDQNMHQAEEWFKCRYAK-LTEAAE 304
Query: 307 EGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSP 366
+ +E R EE+ + R + +S+ E+ R T+ E + S + +
Sbjct: 305 QNKEAIRSAKEEIAEYRRQLQSKSIEL--ESVRGTKESLERQLSDIEERHNHDLSSYQDT 362
Query: 367 LEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLTKEASSP 426
+++ E E++ ++ + L +A + EET + P
Sbjct: 363 IQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGP 422
Query: 427 PPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDT 486
L++ PP+ I + +L V QH + V + + D
Sbjct: 423 -----LYTHR---------PPITISSKIQKPKVEAPKLKV-QH--KFVEEIIEETKVEDE 465
Query: 487 KAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDR---SAQPLPLKIEELALAKGIT 543
K+E L + K + + +K+ EPE++ +A+ P+K A A +
Sbjct: 466 KSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK----ATAPEVK 521
Query: 544 EECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRS 603
EE + E++EG+ + Q+ + S + SS ++
Sbjct: 522 EE---EGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578
Query: 604 HSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSR-SRSASSNSRKSLSPGVSR 662
+ + +++ ++ A + ++ + + E +++S +S KS P
Sbjct: 579 EAEAKEEKKVEEKSEEVAT---KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPV 635
Query: 663 DSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQ-PESAEKHVTQ 721
+ K P +E PVP+ V E K ++ S S V+ + S P+S +
Sbjct: 636 EEKGKSPVPKSPV--EEKGKSPVPKSPV-EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 692
Query: 722 RLQPERGSPKKCEAEEA-EPPAATQPQTSETQTSHLPESERIHHTVEEK---EEVTMDTS 777
+ + +G K+ E +E E P + + E + +PE ++ V+E+ E VT+ S
Sbjct: 693 KAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKS 752
Query: 778 -ENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAG 836
+ E + E P+ + + +EE + S K I+V +G
Sbjct: 753 VKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEV 812
Query: 837 NSDTEGGQPGRKRRWGASTATTQKKPS 863
+T+ GR+ G T P+
Sbjct: 813 EQETKEKGSGREEEKGVVTNGLDLSPA 839
Score = 52.8 bits (125), Expect = 2e-06
Identities = 68/324 (20%), Positives = 130/324 (40%), Gaps = 39/324 (12%)
Query: 1027 QLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSN-----PKF 1081
+L+ + G +L + I++ +H +Y + + L G KW +
Sbjct: 330 ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENE--LRGTKWEMARHLREYQDL 387
Query: 1082 LCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERA 1141
L A E+ +R LL + T I PL+ PP + + + +
Sbjct: 388 LNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLK 447
Query: 1142 VREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
V+ ++ E E + E +SE E + E E A S K EKKE
Sbjct: 448 VQHKFVEEIIEETKVEDEKSEMEEALTAITE--------------ELAVSM--KEEKKEA 491
Query: 1202 AQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQK 1261
A+E+ ++ K +P + T ++ ++E E KE E+ ++E+EEE++
Sbjct: 492 AEEKEEEPEAEEEEVAAKKSP----VKATAPEVKEEEGE-----KEEEEGQEEEEEEDEG 542
Query: 1262 EREKEAER---ERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDR 1318
+ +AE E+ E+E+ + E + E E E + ++ + + + +E
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELV 602
Query: 1319 RDTKRHSRSRSRS----TPVRDRG 1338
D K +++S +PV ++G
Sbjct: 603 ADAKVEKPEKAKSPVPKSPVEEKG 626
Score = 41.2 bits (95), Expect = 0.007
Identities = 42/223 (18%), Positives = 90/223 (40%), Gaps = 28/223 (12%)
Query: 1088 EQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWA 1147
+++E + G D+ E +E++G + EQ E E +
Sbjct: 533 QEEEEEEDEGAKSDQAEEGGSEKEG--------------SSEKEEGEQEEGETEAEAEGE 578
Query: 1148 EREREMERRERTRSEREWDRD------KVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
E E + E++ +SE ++ KV + +++S +E+ KS KS +EK
Sbjct: 579 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 638
Query: 1202 AQEEPPAKLLDDLFR--------KTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
+ P +++ + + K + P+ + E AK + + K
Sbjct: 639 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 698
Query: 1254 EQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296
+++EE+++ KEA +E + + EK ++ ++ E + E
Sbjct: 699 GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 741
Score = 39.7 bits (91), Expect = 0.020
Identities = 43/191 (22%), Positives = 79/191 (41%), Gaps = 13/191 (6%)
Query: 1119 PPPPPPVQPP-QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSR 1177
P P PV+ + P + +E+ E + +S E + K G +
Sbjct: 642 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 701
Query: 1178 SRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQK 1237
++ KE K +EK +K+EK ++ P K + ++ A + +T S V
Sbjct: 702 KEEEEKEVKEAPK-EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV---TITKSVKVHL 757
Query: 1238 EAERAERAK----EREKRRKEQE---EEEQKEREKEAERERNRQLERE-KRREHSRERDR 1289
E E E K E+EK + E EEE ++ + R+ + + E + +E + +
Sbjct: 758 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETK 817
Query: 1290 ERERERERDRG 1300
E+ RE ++G
Sbjct: 818 EKGSGREEEKG 828
Score = 37.4 bits (85), Expect = 0.098
Identities = 69/326 (21%), Positives = 114/326 (34%), Gaps = 57/326 (17%)
Query: 669 TETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQP--- 725
T+ +D S E A + + KE ++ + +PE+ E+ V + P
Sbjct: 460 TKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE----EEPEAEEEEVAAKKSPVKA 515
Query: 726 ----------ERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKE---EV 772
E+ + E EE E A Q E + SE+ EE E E
Sbjct: 516 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA 575
Query: 773 TMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKG 832
+ +E + E V E +A + + + VE EK +S +PKS +
Sbjct: 576 EGEEAEAKEEKKVEEKSEEVATK--EELVADAKVEKPEKAKSPVPKSPVEE----KGKSP 629
Query: 833 VPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHA 892
VP + +G P K S E KS +P P+ +
Sbjct: 630 VPKSPVEEKGKSPVPK----------------SPVEEKGKSPVPK-SPVEEK-------- 664
Query: 893 DDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQRE------EEEEEKEPEA 946
S +S+ E ++ ++ +V E +E ++E EE+ EK+ E
Sbjct: 665 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 724
Query: 947 EPPVPPQVSVEVALPPPAEHEVKKVT 972
VP + E + A EV +T
Sbjct: 725 PKDVPEKKKAESPVKEEAVAEVVTIT 750
Score = 33.5 bits (75), Expect = 1.4
Identities = 36/165 (21%), Positives = 67/165 (40%), Gaps = 21/165 (12%)
Query: 123 PNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASL 182
P S + EE + + + +K++E E+E +EA + E+ + E PE +
Sbjct: 683 PKSPV-EEAKSKAEVGKGEQKEEE------EKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 735
Query: 183 LPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEG 242
P ++ E + KS + EK ++ KP + E+ + EG
Sbjct: 736 SPVKEEAVAEVVTIT-------KSVKVHLEKETKEEGKPLQQEKEKEKAG-------GEG 781
Query: 243 SQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEE 287
E + SR + + ++ +EE E+E +E+ EEE
Sbjct: 782 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
>gi|209862789 microtubule associated monoxygenase, calponin and LIM
domain containing 3 isoform 1 [Homo sapiens]
Length = 2002
Score = 84.3 bits (207), Expect = 7e-16
Identities = 197/918 (21%), Positives = 336/918 (36%), Gaps = 142/918 (15%)
Query: 131 MSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSS 190
+ + S K+ + + + R+A L+E E++ E ++S+L +
Sbjct: 875 LEEPSIAKRLRGTPERIELENYRLSLRQAEALQEVPEETQAE----HNLSSVLDTGAEED 930
Query: 191 LERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEE 250
+ + S S EE+G+ ++E+PR V A ++ + EEE
Sbjct: 931 V----------ASSSSESEMEEEGEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEE 980
Query: 251 DQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREA------------ 298
+ + S EEEEEEEEE E++EEE+ D+E ++S EA
Sbjct: 981 LEASKSFG---------PGNEEEEEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAA 1031
Query: 299 -PI----------LKEFKEEGEEIPRVKP------------EEMMDERPKTRSQEQEVLE 335
P+ ++E +EE P + EE +D P E E E
Sbjct: 1032 DPLEIQADVHWTHIREREEEERMAPASESSASGAPLDENDLEEDVDSEP--AEIEGEAAE 1089
Query: 336 RGGRFTRSQEEARKSHL--ARQQQEKEMKTTSPLE-EEEREIKSSQGLKEKSKSPSPPRL 392
G E H + ++E++ P E E E E++ S+ ++ K P+ P+
Sbjct: 1090 DGDPGDTGAELDDDQHWSDSPSDADRELRLPCPAEGEAELELRVSE---DEEKLPASPKH 1146
Query: 393 TE--DRKKASLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLI 450
E + S + P+++A P+ + P P + +E P E P L+
Sbjct: 1147 QERGPSQATSPIRSPQESAL---LFIPVHSPSTEGPQLPPVPAATQEKSPEERLFPEPLL 1203
Query: 451 QLSPPNTDADTR----ELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLV-- 504
P DA + + V L +P+S S A P S LP+
Sbjct: 1204 PKEKPKADAPSDLKAVHSPIRSQPVTLPEARTPVSPGSPQPQPPVAASTPPPSPLPICSQ 1263
Query: 505 -QKSTLADYSAQKD----LEPESDRSAQPL-PLKIEELALAKG------ITEECLKQPSL 552
Q ST A + +P +++ PL PL ++ + K +E L++ L
Sbjct: 1264 PQPSTEATVPSPTQSPIRFQPAPAKTSTPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDL 1323
Query: 553 EQK-----EGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPL 607
++ R S L P R K S + + S S S +SP G PL
Sbjct: 1324 VEEFWMKSAEIRRSLGLTPVDRSKGPEPSFPTPAFRPVSLKSYSVEKSPQDEGLHLLKPL 1383
Query: 608 RSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTS 667
+R + + P P S S E RS R R SS+S L G S + T
Sbjct: 1384 SIPKR-LGLPKPEGEPLSLPTPRSPSDRELRSAQEER-RELSSSSGLGLH-GSSSNMKTL 1440
Query: 668 YTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPER 727
+++ + +S + TPP P E +T R+L + E V L
Sbjct: 1441 GSQSFN-TSDSAMLTPPSSPPPPPPPGEEPAT-----LRRKLREAEPNASVVPPPLPATW 1494
Query: 728 GSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEK-EEVTMDTSENRPENDVP 786
P + E A+PP ++ +P ++ + T ++K E+ ++ P + P
Sbjct: 1495 MRPPR---EPAQPPREEVRKSFVESVEEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWP 1551
Query: 787 EPPM----PIADQVSNDDRPEGSVEDE---------EKKESSLPKSFKRKISVVS----- 828
P P+A + EG+++ + E KE + + R+ SV S
Sbjct: 1552 RPEKPRHPPLAKENGRLPALEGTLQPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRD 1611
Query: 829 --ATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEA 886
A + + G P ++ A + +++P S P +K A E
Sbjct: 1612 AMARQLSRMQQMELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEE 1671
Query: 887 VVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEA 946
V+ +D T G G K + + +R ++E++ + E
Sbjct: 1672 VLSPPSDSGGPDGSFTSSEGSSGKSKKRSSLF-------------SPRRNKKEKKSKGEG 1718
Query: 947 EPPVPPQVSV--EVALPP 962
PP P ++ E A P
Sbjct: 1719 RPPEKPSSNLLEEAAAKP 1736
Score = 44.7 bits (104), Expect = 6e-04
Identities = 174/898 (19%), Positives = 304/898 (33%), Gaps = 151/898 (16%)
Query: 548 KQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPL 607
K+P++ G+ A L D +++ ++ +++ + S R+P S + P
Sbjct: 829 KRPAVAPLSGKEAKGPL---------QDGATTDANGRANAVASSTERTPGSGVNGLEEPS 879
Query: 608 RSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTS 667
+K+ R + + E ++ A N L G D ++S
Sbjct: 880 IAKRLRGTPERIELENYRLSLRQAEALQEVPEETQ-----AEHNLSSVLDTGAEEDVASS 934
Query: 668 YTETKDPSSGQEVATPP-VPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQPE 726
+E++ G+E P +P + + + ++ + + A K + E
Sbjct: 935 SSESEMEEEGEEEEEEPRLPPSDLGGVPWKEAVRIHALLKGKSEEELEASKSFGPGNEEE 994
Query: 727 RGSPKKCEAEEAEPPAATQPQTSET------QTSHLPESERIH------HTVEEKEEVTM 774
++ E EE E + ++SE Q H + I H E +EE M
Sbjct: 995 EEEEEEYEEEEEEDYDEEEEESSEAGNQRLQQVMHAADPLEIQADVHWTHIREREEEERM 1054
Query: 775 DTS-----------ENRPENDVPEPPMPIADQVSNDDRP--EGSVEDEEKKESSLPKSFK 821
+ EN E DV P I + + D P G+ D+++ S P
Sbjct: 1055 APASESSASGAPLDENDLEEDVDSEPAEIEGEAAEDGDPGDTGAELDDDQHWSDSPSDAD 1114
Query: 822 RKISVVSATKG---VPAGNSDTEGGQPG--RKRRWGASTATT-----QKKPSISITTESL 871
R++ + +G + S+ E P + + G S AT+ Q+ + I S
Sbjct: 1115 RELRLPCPAEGEAELELRVSEDEEKLPASPKHQERGPSQATSPIRSPQESALLFIPVHSP 1174
Query: 872 KSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQE 931
+ P + P+ A + ++ E + LK + + P E
Sbjct: 1175 STEGPQLPPVPA--ATQEKSPEERLFPEPLLPKEKPKADAPSDLKAVHSPIRSQPVTLPE 1232
Query: 932 NGQREEEEEEKEPEAEPPVP--------------PQVSVEVALPPPAEHEVK-KVTLGDT 976
P+ +PPV PQ S E +P P + ++ + T
Sbjct: 1233 ---ARTPVSPGSPQPQPPVAASTPPPSPLPICSQPQPSTEATVPSPTQSPIRFQPAPAKT 1289
Query: 977 LT--------RRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQL 1028
T +S ++ + G + +D+ +R + + K + I R L +
Sbjct: 1290 STPLAPLPVQSQSDTKDRLGSPLAVDEALRRSDLVEEFWMKSAEIR------RSLGLTPV 1343
Query: 1029 KELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALH-----GVKWPQSNP---- 1079
G + AF +KS+ V S +E + L G+ P+ P
Sbjct: 1344 DRSKGPEPSFPTPAFRPVSLKSYS-VEKSPQDEGLHLLKPLSIPKRLGLPKPEGEPLSLP 1402
Query: 1080 -------KFLCADYAEQDELDYHRGL-----------LVDRPSETKTEEQGIPRPLHPPP 1121
+ L + E+ EL GL L + T P PPP
Sbjct: 1403 TPRSPSDRELRSAQEERRELSSSSGLGLHGSSSNMKTLGSQSFNTSDSAMLTPPSSPPPP 1462
Query: 1122 PPPVQPPQHPRAEQREQE-------RAVREQWAEREREMERRERTRSEREWDRDKVREGP 1174
PPP + P R + RE E + W RE + R + + + V E P
Sbjct: 1463 PPPGEEPATLRRKLREAEPNASVVPPPLPATWMRPPREPAQPPREEVRKSF-VESVEEIP 1521
Query: 1175 RS-------RSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAK------LLDDLFRKTKAA 1221
+ ++ D +E+ + + EK + P AK L+ + K
Sbjct: 1522 FADDVEDTYDDKTEDSSLQEKFFTPPSCWPRPEKPRHPPLAKENGRLPALEGTLQPQKRG 1581
Query: 1222 PCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRR 1281
LPL AE E A+ER R +E+ + Q R+ A RQL R ++
Sbjct: 1582 -----LPLV-------SAEAKELAEER-MRAREKSVKSQALRDAMA-----RQLSRMQQM 1623
Query: 1282 EHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGG 1339
E + R R+ +G R R R + K + S +P D GG
Sbjct: 1624 ELASGAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGG 1681
Score = 37.0 bits (84), Expect = 0.13
Identities = 41/179 (22%), Positives = 79/179 (44%), Gaps = 10/179 (5%)
Query: 1129 QHPRAEQREQ-ERAVREQWAEREREMERRERTRSE-REWDRDKVREGPRSRSRSRDRRRK 1186
Q R E R E + + R ++ RR+ + E + R ++ + + R RR +
Sbjct: 1810 QKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQRRLE 1869
Query: 1187 ERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAK 1246
ER + EK + ++ KL+ + F+ + + ++ I +E E +R
Sbjct: 1870 ERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYE-SELMIFARELELEDRQS 1928
Query: 1247 --EREKRRKEQEEEEQKEREKEAERER--NRQLEREKRREHS---RERDRERERERERD 1298
++E R + E+ K E+ +E ++ N LE ++R+ E R RERE ++D
Sbjct: 1929 RLQQELRERMAVEDHLKTEEELSEEKQILNEMLEVVEQRDSLVALLEEQRLREREEDKD 1987
Score = 35.0 bits (79), Expect = 0.48
Identities = 45/246 (18%), Positives = 81/246 (32%), Gaps = 36/246 (14%)
Query: 1112 GIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVR 1171
G PRP P + P + R R E + E E S+
Sbjct: 1628 GAPRPRKASSAPSQGKERRPDSPTRPTLRGSEEPTLKHEATSEEVLSPPSDSGGPDGSFT 1687
Query: 1172 EGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTD 1231
S +S+ +R + K EKK K + PP K +L + A P W +
Sbjct: 1688 SSEGSSGKSK--KRSSLFSPRRNKKEKKSKGEGRPPEKPSSNLLEEAAAKPKSLWKSVFS 1745
Query: 1232 SQIVQKEAERAERA----------------------KEREKRRKEQEEEEQKEREKEAER 1269
K+ + +++ + + R++ E + +
Sbjct: 1746 GYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSFSEDSDLSSDDVL 1805
Query: 1270 ERNRQLEREKRREHSRER------------DRERERERERDRGDRDRDRERDRERGRERD 1317
E++ Q R + R ++ E R + ++ E R R + +R ++ ER
Sbjct: 1806 EKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLQQVEERQ 1865
Query: 1318 RRDTKR 1323
RR +R
Sbjct: 1866 RRLEER 1871
Score = 33.5 bits (75), Expect = 1.4
Identities = 69/351 (19%), Positives = 128/351 (36%), Gaps = 50/351 (14%)
Query: 7 PRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVT 66
P SGG G + + G G + F R K K + G P LEE
Sbjct: 1676 PSDSGGPDGSFTSSEGSS-GKSKKRSSLFSPRRNKKEKKSKGEGRPPEKPSSNL-LEEAA 1733
Query: 67 LDGKPLQALRVT----DLKAALEQRGLAKSGQKSALVKRLKGALM------LENLQKHST 116
K L + D K + + + A V K ++ L+ ++ S
Sbjct: 1734 AKPKSLWKSVFSGYKKDKKKKADDKSCPSTPSSGATVDSGKHRVLPVVRAELQLRRQLSF 1793
Query: 117 PHAAFQPNSQIGEEMSQNSFIKQYLEKQQEL---LRQRLEREAREAAELEEASAESEDEM 173
+ + + E+ SQ S + ++EL L +R+++ AR A+ EE ++
Sbjct: 1794 SEDSDLSSDDVLEKSSQKSRREPRTYTEEELNAKLTRRVQKAARRQAKQEELKRLHRAQI 1853
Query: 174 IHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQ 233
I + +E + L ++ E G + P+ + V++
Sbjct: 1854 IQRQ----------LQQVEERQRRLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQE 1903
Query: 234 ARA-----AKLSEGSQPAEEEEDQETPSRNLRVR--ADRNLKTEEEEEEEEEEEEDDEEE 286
A ++L ++ E E+ Q + LR R + +LKTEEE EE++ +
Sbjct: 1904 KNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEEELSEEKQILNE---- 1959
Query: 287 EGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERG 337
+ E E+ + + + E+ + ER + + E +L +G
Sbjct: 1960 --------------MLEVVEQRDSLVALLEEQRLREREEDKDLEAAMLSKG 1996
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 83.6 bits (205), Expect = 1e-15
Identities = 66/232 (28%), Positives = 110/232 (47%), Gaps = 44/232 (18%)
Query: 1121 PPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRS 1180
PPPP +PP + ER +R +E+ ++ R E+E D +
Sbjct: 289 PPPPPEPPT-----ESAWERGLRHA-----KEVLKKATIRKEQEPDFE------------ 326
Query: 1181 RDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQI------ 1234
++R E++ +K+ + + +++ D+ R T P Y P D +I
Sbjct: 327 -EKRFTVTIGEDEREFDKENEVFRDWNSRIPRDV-RDTVLEP--YADPYYDYEIERFWRG 382
Query: 1235 ----------VQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHS 1284
+ E R +ERE+ R+ ++ E ++ERE++ ERER RQ ERE+ REH
Sbjct: 383 GQYENFRVQYTETEPYHNYRERERERERENRQRERERERERDRERER-RQREREREREHE 441
Query: 1285 RERDRERERER-ERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVR 1335
R+++R+R +E ER+R RD + R+R RE++R K + RS P R
Sbjct: 442 RDKERQRRKEEWERERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSR 493
Score = 78.6 bits (192), Expect = 4e-14
Identities = 135/595 (22%), Positives = 210/595 (35%), Gaps = 88/595 (14%)
Query: 193 RPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQ 252
R E E R + +I E++ + D E + S R R L + P + E +
Sbjct: 318 RKEQEPDFEEKRFTVTIGEDEREFDKENEVFRDWNSRIPRDVRDTVLEPYADPYYDYEIE 377
Query: 253 ET----PSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEG 308
N RV+ E E E E ++ + E + E ++ RE
Sbjct: 378 RFWRGGQYENFRVQYTETEPYHNYRERERERERENRQRERERERERDRER---------- 427
Query: 309 EEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLE 368
E R + E ER K R + +E ER E A++ RQ ++++
Sbjct: 428 ERRQREREREREHERDKERQRRKEEWER--------ERAKRDEKDRQHRDRD-------R 472
Query: 369 EEEREIKSSQGLKEKSKSPSPP-RLTEDRKKASLVALPEQTASEEETPPPLLTK------ 421
E+ERE + K K +SP PP R E KK + P+ ++E P +K
Sbjct: 473 EKEREKEKG---KPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKL 529
Query: 422 ---------------EASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLV 466
ASS S G S + +R
Sbjct: 530 GVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRSSRH 589
Query: 467 SQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSA 526
S + S SSPS + SP P + S +K P + A
Sbjct: 590 SSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQA 649
Query: 527 QPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSS 586
+ E +P + +E RR R + + S S SS S
Sbjct: 650 TKTTAPVPEPT-----------KPG-DPREARRKERPARTPPRRRTLSGSGSGSGSSYSG 697
Query: 587 SSSRSRSRSPDSSGSRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSR 646
SSSRSRS S S S S + S + P S++ SRS + +++R
Sbjct: 698 SSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPV----SSASSRSPAPAQTR 753
Query: 647 SASSNSRKSLSPGV-----SRDSSTSYTET-KDPSSGQEVATPPVP-QLQVCEPKERTST 699
S+K GV RDSST ++ K P+ G+ P P Q +P++ T
Sbjct: 754 KEKGKSKK--EDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPSTPQQAPPGQPQQGTFV 811
Query: 700 SSSSVQARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTS 754
+ ++ L+ ++A+K +R +P + + PP A +P TS + S
Sbjct: 812 AHKEIKLTLLN--KAADKGSRKRYEPS-------DKDRQSPPPAKRPNTSPDRGS 857
Score = 66.2 bits (160), Expect = 2e-10
Identities = 58/213 (27%), Positives = 93/213 (43%), Gaps = 14/213 (6%)
Query: 1126 QPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRR 1185
+P + R +RE+ER R++ ERERE +R ER R +RE +R++ E + R R ++
Sbjct: 396 EPYHNYRERERERERENRQRERERERERDR-ERERRQREREREREHERDKERQRRKEEWE 454
Query: 1186 KERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEA----ER 1241
+ERAK EK + +++ +E+ K K K P P ++ +KEA +
Sbjct: 455 RERAKRDEKDRQHRDRDREKEREK------EKGKPKPRSPQPPSRQAEPPKKEAATTGPQ 508
Query: 1242 AERAKEREK--RRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDR 1299
+RA E + RR + +++ + R R+ + R R
Sbjct: 509 VKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSG 568
Query: 1300 GDRDRDRERDRERGRERDRRDTK-RHSRSRSRS 1331
R R R R R + SRSRSRS
Sbjct: 569 SSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRS 601
Score = 57.4 bits (137), Expect = 9e-08
Identities = 105/530 (19%), Positives = 194/530 (36%), Gaps = 56/530 (10%)
Query: 212 EKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEEDQETPSRN---LRVRADRNLK 268
E+ + E+ R+ ER R R+ R E + E E D+E R R RA R+ K
Sbjct: 409 ERENRQRERERERERDRERERRQR-----EREREREHERDKERQRRKEEWERERAKRDEK 463
Query: 269 TEEEEEEEEEEEEDDEEEEGDDEGQK--SREA-PILKEFKEEGEEIPRVKPEEMMDERPK 325
+ + + E+E + E+ + + SR+A P KE G ++ R + R K
Sbjct: 464 DRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSK 523
Query: 326 TRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKEMKTT--SPLEEEEREIKSSQGLKEK 383
+ ++ V R R ++ + S A +++ S +SS
Sbjct: 524 SPKKKLGVSVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYS 583
Query: 384 SKSPSPPRLTEDRKKA-SLVALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPME 442
S+S + R ++ S + P + + P + TK +PPP + + +P
Sbjct: 584 SRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPPP-GKAGEKSVKKPAP 642
Query: 443 GPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLP 502
PAPP + + P V + T P + E PA P L
Sbjct: 643 PPAPPQATKTTAP----------VPEPT-------KPGDPREARRKERPARTPPRRRTLS 685
Query: 503 LVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKE--GRRA 560
+ + YS S++ L + ++ T S++ ++ A
Sbjct: 686 GSGSGSGSSYSGS---------SSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLA 736
Query: 561 SHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGS--RSHSPLRSKQRDVAQAR 618
S S R A + + S + R DSS +S P + +
Sbjct: 737 SPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQPST 796
Query: 619 THANPRGRPKMGS-------RSTSESRSRSR-SRSRSASSNSRKSLSPGVSRDSSTSYTE 670
P G+P+ G+ + T +++ + SR R S+ + P R +++
Sbjct: 797 PQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRG 856
Query: 671 TKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT 720
++D SG + +P P+ Q + + ++ + + R+LS + VT
Sbjct: 857 SRDRKSGGRLGSPK-PERQ--RGQNSKAPAAPADRKRQLSPQSKSSSKVT 903
Score = 56.6 bits (135), Expect = 2e-07
Identities = 77/306 (25%), Positives = 111/306 (36%), Gaps = 43/306 (14%)
Query: 551 SLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSK 610
S+ RR T S S+ SSS SS S S SSRSRSRS S S S
Sbjct: 532 SVSPSRARRRRKTSASSASASNSSRSSSRSSSYSGSGSSRSRSRSSSYSSYSSRS----- 586
Query: 611 QRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTE 670
S S S SRSRSRS SS+ S +P R S + E
Sbjct: 587 ----------------------SRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGE 624
Query: 671 TKDP--SSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQP-ESAEKHVTQRLQPER 727
P +G++ P P P + T T++ + + P E+ K R P R
Sbjct: 625 PAPPPGKAGEKSVKKPAPP---PAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRR 681
Query: 728 ------GSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRP 781
GS + + + +S + S S H+V+ ++ S
Sbjct: 682 RTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSS 741
Query: 782 ENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSL--PKSFKRKISVVSATKGVPAGNSD 839
+ P + + +G E++ K++SS PKS K S+ + P+
Sbjct: 742 ASSRSPAPAQTRKEKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQ--PSTPQQ 799
Query: 840 TEGGQP 845
GQP
Sbjct: 800 APPGQP 805
Score = 53.1 bits (126), Expect = 2e-06
Identities = 167/880 (18%), Positives = 307/880 (34%), Gaps = 126/880 (14%)
Query: 153 EREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEE 212
ER+ + E+ S+D+++ G L + + +LE + R S EE
Sbjct: 8 ERDPHSPEDEEQPQGLSDDDILRDSGSDQDLDG---AGVRASDLEDEESAARGPSQ--EE 62
Query: 213 KGDSDDEKPRKGERRSSRVRQARAAKLSEG--SQPAEEEEDQETPSRNLRVRADRNLKTE 270
+ + DE+ R E +S + + +LS G S P EEE D+ R +R + + T
Sbjct: 63 EDNHSDEEDRASEPKSQD-QDSEVNELSRGPTSSPCEEEGDEGEEDRTSDLRDEASSVTR 121
Query: 271 EEEEEEEEEEEDDEEEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQE 330
E +E E + +E+ EE + E ++ +E+GE P R + ++
Sbjct: 122 ELDEHELDYDEEVPEEPAPAVQEDEAEKAGAEDDEEKGEGTP----------REEGKAGV 171
Query: 331 QEVLERGGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPP 390
Q V E+ S E A++ E + + EE E+K K + + P+
Sbjct: 172 QSVGEK-----ESLEAAKEKKKEDDDGEIDDGEIDDDDLEEGEVKDPSDRKVRPR-PTCR 225
Query: 391 RLTEDRKKASLVALPEQTASEEETPPPLLTKEASSPP-------PHPQLHSEEEIEPMEG 443
+ + ++ L+TK PP PHP + + P G
Sbjct: 226 FFMKGNCTWGMNCRFIHPGVNDKGNYSLITKADPFPPNGAPPLGPHPLMPA----NPWGG 281
Query: 444 PAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPL 503
P ++ PP ++ +H ++ L + K + P + +V
Sbjct: 282 PVVDEILPPPPPEPPTESAWERGLRHAKEV------LKKATIRKEQEPDFEEKRFTV--- 332
Query: 504 VQKSTLADYSAQKDLEPESDRS-AQPLPLKIEELALAKGITEECLKQPSLE--------- 553
T+ + + D E E R +P + + L E P +
Sbjct: 333 ----TIGEDEREFDKENEVFRDWNSRIPRDVRDTVL------EPYADPYYDYEIERFWRG 382
Query: 554 -QKEGRRASHT-LLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQ 611
Q E R +T P H ++ + R R R + R R +
Sbjct: 383 GQYENFRVQYTETEPYHNYRERERERERENRQRERERERERDRERERR-QREREREREHE 441
Query: 612 RD-VAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSP--------GVSR 662
RD Q R R R K + + R R R + R K SP +
Sbjct: 442 RDKERQRRKEEWERERAKRDEKD-RQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKK 500
Query: 663 DSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQR 722
+++T+ + K ++ P + PK++ S S +ARR + ++ +
Sbjct: 501 EAATTGPQVKRADEWKD------PWRRSKSPKKKLGVSVSPSRARRRRKTSASSASAS-- 552
Query: 723 LQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPE 782
R S + + + ++ S + +S+ S R H + + S +
Sbjct: 553 -NSSRSSSR--SSSYSGSGSSRSRSRSSSYSSYSSRSSR-HSSFSGSRSRSRSFSSSPSP 608
Query: 783 NDVPEPPMPIADQVSNDDRPEGSVEDEEKKE----SSLPKSFKRKISVVSATK-GVP--A 835
+ P P P P G ++ K+ + P++ K V TK G P A
Sbjct: 609 SPTPSPHRPSIRTKGEPAPPPGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREA 668
Query: 836 GNSDTEGGQPGRKRRWGAS--------TATTQKKPSISITTESLKSLIPDIKPLAGQEAV 887
+ P R+R S + ++ + S+S+++ S S A
Sbjct: 669 RRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDS 728
Query: 888 VDLHAD--------------DSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENG 933
D++AD ++ +++ + +DG ++ K R + P +
Sbjct: 729 EDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRK--RDSSTQPPKSAKPPA 786
Query: 934 QREEEEEEKEPEAEPPVPPQVSVEVALPPPAEHEVKKVTL 973
+ ++ P+ PP PQ VA H+ K+TL
Sbjct: 787 GGKSSQQPSTPQQAPPGQPQQGTFVA------HKEIKLTL 820
Score = 43.1 bits (100), Expect = 0.002
Identities = 92/434 (21%), Positives = 149/434 (34%), Gaps = 68/434 (15%)
Query: 934 QREEEEEEKEPEAEPPVPPQVSVEVALPPPAEH-----EVKKVTLGDTLTRRSISQQKS- 987
++E E+E+ +P+ P PP E PP E +VK+ RRS S +K
Sbjct: 473 EKEREKEKGKPKPRSPQPPSRQAE---PPKKEAATTGPQVKRADEWKDPWRRSKSPKKKL 529
Query: 988 GVSITIDDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDK 1047
GVS++ R + S SN S+ R+ + +
Sbjct: 530 GVSVS-PSRARRRRKTSASSASASNSSRSSS---------------RSSSYSGSGSSRSR 573
Query: 1048 IKSHCFVTYSTVEEAVATRTALHG-VKWPQSNPKFLCADYAEQDELDYHRGLLVDR---- 1102
+S + +YS+ R++ H +S + + + HR + +
Sbjct: 574 SRSSSYSSYSS-------RSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPA 626
Query: 1103 PSETKTEEQGIPRPLHPPPPP-------PVQPPQHPRAEQREQERAVREQWAEREREMER 1155
P K E+ + +P PP PP PV P P + RE R ER
Sbjct: 627 PPPGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKP-GDPREARR------KERPARTPP 679
Query: 1156 RERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLF 1215
R RT S G SRSRS S S E + DL
Sbjct: 680 RRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSE---DMYADLA 736
Query: 1216 RKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQL 1275
+A P + +K + E + EKR+++ + K + A + ++Q
Sbjct: 737 SPVSSASSRSPAPAQTRK--EKGKSKKEDGVKEEKRKRDSSTQPPKSAKPPAGGKSSQQP 794
Query: 1276 EREKRREHSRERDRERERERE---------RDRGDRDRDRERDRERGRERDRRDTKRHSR 1326
++ + + +E D+G R R D++R + KR +
Sbjct: 795 STPQQAPPGQPQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDR---QSPPPAKRPNT 851
Query: 1327 SRSRSTPVRDRGGR 1340
S R + R GGR
Sbjct: 852 SPDRGSRDRKSGGR 865
Score = 34.7 bits (78), Expect = 0.63
Identities = 44/203 (21%), Positives = 78/203 (38%), Gaps = 28/203 (13%)
Query: 1133 AEQREQERAVREQWAERE-REMERRERTRSEREWDRD----KVREGPRSRSRSRDRRRKE 1187
++ ++E A R E E + +R + D+D ++ GP S + E
Sbjct: 46 SDLEDEESAARGPSQEEEDNHSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGE 105
Query: 1188 RAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKE 1247
++ + + E +E +L D + AP + + EAE+A +
Sbjct: 106 EDRTSDLRDEASSVTRELDEHELDYDEEVPEEPAPAVQ----------EDEAEKAGAEDD 155
Query: 1248 REKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRE 1307
EK EE + + E+E + + +EK++E + + E D G+ D D
Sbjct: 156 EEKGEGTPREEGKAGVQSVGEKE-SLEAAKEKKKE---------DDDGEIDDGEIDDD-- 203
Query: 1308 RDRERGRERDRRDTKRHSRSRSR 1330
D E G +D D K R R
Sbjct: 204 -DLEEGEVKDPSDRKVRPRPTCR 225
Score = 33.1 bits (74), Expect = 1.8
Identities = 105/580 (18%), Positives = 196/580 (33%), Gaps = 54/580 (9%)
Query: 705 QARRLSQPESAEKHVTQRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHH 764
+ R ++ E+ + + ER ++ E E Q + E + E+
Sbjct: 407 ERERENRQRERERERERDRERERRQREREREREHERDKERQRRKEEWERERAKRDEKDRQ 466
Query: 765 TVEEKEEVTMDTSENRPENDVPEPPMPIADQVSNDDR---PEGSVEDEEKKESSLPKSFK 821
+ E + + +P+ P+PP A+ + P+ DE K KS K
Sbjct: 467 HRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPK 526
Query: 822 RKISV-VSATKGVPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKP 880
+K+ V VS ++ + R +S+ ++ S S + S S
Sbjct: 527 KKLGVSVSPSRARRRRKTSASSASASNSSR--SSSRSSSYSGSGSSRSRSRSSSYSSYSS 584
Query: 881 LAGQEAVVDLHADDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEE 940
+ + + SR + H + RT + P G+ E+
Sbjct: 585 RSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSI---RTKGEPAPPPGKAG-----EKS 636
Query: 941 EKEPEAEPPVPPQVSVEVALPP-------PAEHEVKKVTLGDTLTRRSISQQKSGVSITI 993
K+P A PP PPQ + A P P E K+ RR++S SG
Sbjct: 637 VKKP-APPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSG--- 692
Query: 994 DDPVRTAQVPSPPRGKISNIVHISNLVRPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCF 1053
++ S R + ++ +S++ + + + A + S
Sbjct: 693 -----SSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSP 747
Query: 1054 VTYSTVEEAVATRTALHGVKWPQSNPKFLCADYAEQDELDYHRGLLVDRPSETKTEEQG- 1112
T +E ++ GVK E R P K G
Sbjct: 748 APAQTRKEKGKSKKE-DGVK-----------------EEKRKRDSSTQPPKSAKPPAGGK 789
Query: 1113 -IPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVR 1171
+P P PP QP Q +E + + + A++ +R E + +R+ R
Sbjct: 790 SSQQPSTPQQAPPGQPQQGTFVAHKEIKLTLLNKAADK-GSRKRYEPSDKDRQSPPPAKR 848
Query: 1172 EGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQ-EEPPAKLLDDLFRKTKAAPCIYWLP-- 1228
SRDR+ R S + + ++ + ++ PA L ++K++ + +P
Sbjct: 849 PNTSPDRGSRDRKSGGRLGSPKPERQRGQNSKAPAAPADRKRQLSPQSKSSSKVTSVPGK 908
Query: 1229 LTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAE 1268
+D ++ +A RE+ K+ + E K A+
Sbjct: 909 ASDPGAASTKSGKASTLSRREELLKQLKAVEDAIARKRAK 948
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 83.2 bits (204), Expect = 2e-15
Identities = 99/430 (23%), Positives = 180/430 (41%), Gaps = 46/430 (10%)
Query: 139 QYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASLL-----PPDFQSSLER 193
++L + Q+LL ++ + AA + E + L P S +++
Sbjct: 3 RHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQK 62
Query: 194 PELELSRHSPRKS--SSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGSQPAEEEED 251
P++E + + I EE D++ E + + + A + E + A EE++
Sbjct: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEM--EEALTAITEELAVSMKEEKKEAAEEKE 120
Query: 252 QETPSRNLRVRADRN--------LKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPILKE 303
+E + V A ++ +K EE E+EEEE +E++EEE+ + ++ E KE
Sbjct: 121 EEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKE 180
Query: 304 ---FKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE 360
KEEGE+ E E + + +E++V E+ +E + + + ++ K
Sbjct: 181 GSSEKEEGEQEEGETEAEAEGEEAEAK-EEKKVEEKSEEVATKEELVADAKVEKPEKAKS 239
Query: 361 MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALP-EQTASEEETPPPLL 419
SP+EE+ + ++EK KSP P E++ K+ + P E+ + P+
Sbjct: 240 PVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVE 299
Query: 420 TKEASSPPPHPQLHSEEEIEPMEG---PAPPVLIQLSPPNTDADTRELLVSQHTVQLVGG 476
K S P P ++ + E +G ++ +P + +E
Sbjct: 300 EKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKE------------- 346
Query: 477 LSPLSSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPL-KIEE 535
P P KAESP V EE+V +V + S + LE E+ +PL K +E
Sbjct: 347 EKPKDVPEKKKAESP---VKEEAVAEVVTITK----SVKVHLEKETKEEGKPLQQEKEKE 399
Query: 536 LALAKGITEE 545
A +G +EE
Sbjct: 400 KAGGEGGSEE 409
Score = 55.5 bits (132), Expect = 3e-07
Identities = 70/297 (23%), Positives = 132/297 (44%), Gaps = 47/297 (15%)
Query: 142 EKQQELLRQRLEREAREAAELEEASAE--SEDEMIHPEGVASLLPPDFQSSLERPELELS 199
E + E + E EA+E ++EE S E +++E++ V P +S + + +E
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEK--PEKAKSPVPKSPVEEK 249
Query: 200 RHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQA---RAAKLSEGSQPAEEEEDQ---E 253
SP S + EEKG S K E+ S V ++ K P EE+ +
Sbjct: 250 GKSPVPKSPV-EEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPK 308
Query: 254 TPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAP-------------- 299
+P + +A+ K E++EEEE+E +E +EE+ + + +K ++ P
Sbjct: 309 SPVEEAKSKAEVG-KGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAV 367
Query: 300 -------------ILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEE 346
+ KE KEEG+ + + K +E + E+E ++G + +R ++
Sbjct: 368 AEVVTITKSVKVHLEKETKEEGKPLQQEKEKE---KAGGEGGSEEEGSDKGAKGSRKEDI 424
Query: 347 ARKSHL-ARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLV 402
A + +++ E+E K EEE+ + ++ GL SP+ + D+ + +V
Sbjct: 425 AVNGEVEGKEEVEQETKEKGSGREEEKGVVTN-GL---DLSPADEKKGGDKSEEKVV 477
Score = 54.3 bits (129), Expect = 8e-07
Identities = 75/336 (22%), Positives = 123/336 (36%), Gaps = 50/336 (14%)
Query: 623 PRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSSTSYTETKDPSSGQEVAT 682
P + + G + E + A S+ + G S +S E + G+ A
Sbjct: 142 PEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE---GGSEKEGSSEKEEGEQEEGETEAE 198
Query: 683 PPVPQLQVCEPK------ERTSTSSSSVQARRLSQPESAEKHVTQRLQPERGS---PKKC 733
+ + E K E +T V ++ +PE A+ V + E+G PK
Sbjct: 199 AEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP 258
Query: 734 EAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENRPENDVPEPPMPIA 793
E+ + P P E S +P+S VEEK + + S + P P P+
Sbjct: 259 VEEKGKSPVPKSP-VEEKGKSPVPKSP-----VEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
Query: 794 DQVSNDDRPEGSVEDEEKKE-SSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKRRWG 852
+ S + +G ++EE+KE PK K V + P + + + K
Sbjct: 313 EAKSKAEVGKGEQKEEEEKEVKEAPKEEK-----VEKKEEKPKDVPEKKKAESPVKEEAV 367
Query: 853 ASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISEDETERNGDDG--- 909
A T K + + E+ + + KPL E E E+ G +G
Sbjct: 368 AEVVTITKSVKVHLEKETKE----EGKPLQ---------------QEKEKEKAGGEGGSE 408
Query: 910 --THDKGLKICRTVTQVVPAEGQENGQREEEEEEKE 943
DKG K R + + G+ G+ E E+E KE
Sbjct: 409 EEGSDKGAKGSR--KEDIAVNGEVEGKEEVEQETKE 442
Score = 53.5 bits (127), Expect = 1e-06
Identities = 85/434 (19%), Positives = 165/434 (38%), Gaps = 26/434 (5%)
Query: 440 PMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEES 499
P+ PP+ I + +L V QH + V + + D K+E
Sbjct: 46 PLYTHRPPITISSKIQKPKVEAPKLKV-QH--KFVEEIIEETKVEDEKSEMEEALTAITE 102
Query: 500 VLPLVQKSTLADYSAQKDLEPESDR---SAQPLPLKIEELALAKGITEECLKQPSLEQKE 556
L + K + + +K+ EPE++ +A+ P+K A A + EE + E++E
Sbjct: 103 ELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVK----ATAPEVKEE---EGEKEEEE 155
Query: 557 GRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQRDVAQ 616
G+ + Q+ + S + SS ++ + + +++ +
Sbjct: 156 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEK 215
Query: 617 ARTHANPRGRPKMGSRSTSESRSRSRSR-SRSASSNSRKSLSPGVSRDSSTSYTETKDPS 675
+ A + ++ + + E +++S +S KS P + K P
Sbjct: 216 SEEVAT---KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 272
Query: 676 SGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQ-PESAEKHVTQRLQPERGSPKKCE 734
+E PVP+ V E K ++ S S V+ + S P+S + + + +G K+ E
Sbjct: 273 --EEKGKSPVPKSPV-EEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEE 329
Query: 735 AEEA-EPPAATQPQTSETQTSHLPESERIHHTVEEK---EEVTMDTSEN-RPENDVPEPP 789
+E E P + + E + +PE ++ V+E+ E VT+ S E + E
Sbjct: 330 EKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEG 389
Query: 790 MPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDTEGGQPGRKR 849
P+ + + +EE + S K I+V +G +T+ GR+
Sbjct: 390 KPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREE 449
Query: 850 RWGASTATTQKKPS 863
G T P+
Sbjct: 450 EKGVVTNGLDLSPA 463
Score = 48.9 bits (115), Expect = 3e-05
Identities = 56/255 (21%), Positives = 106/255 (41%), Gaps = 32/255 (12%)
Query: 1091 ELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWAERE 1150
E+ +R LL + T I PL+ PP + + + + V+ ++ E
Sbjct: 21 EIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEI 80
Query: 1151 REMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKL 1210
E + E +SE E + E E A S K EKKE A+E+
Sbjct: 81 IEETKVEDEKSEMEEALTAITE--------------ELAVSM--KEEKKEAAEEKEEEPE 124
Query: 1211 LDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAER- 1269
++ K +P + T ++ ++E E KE E+ ++E+EEE++ + +AE
Sbjct: 125 AEEEEVAAKKSP----VKATAPEVKEEEGE-----KEEEEGQEEEEEEDEGAKSDQAEEG 175
Query: 1270 --ERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRS 1327
E+ E+E+ + E + E E E + ++ + + + +E D K
Sbjct: 176 GSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE 235
Query: 1328 RSRS----TPVRDRG 1338
+++S +PV ++G
Sbjct: 236 KAKSPVPKSPVEEKG 250
Score = 41.2 bits (95), Expect = 0.007
Identities = 42/223 (18%), Positives = 90/223 (40%), Gaps = 28/223 (12%)
Query: 1088 EQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAVREQWA 1147
+++E + G D+ E +E++G + EQ E E +
Sbjct: 157 QEEEEEEDEGAKSDQAEEGGSEKEG--------------SSEKEEGEQEEGETEAEAEGE 202
Query: 1148 EREREMERRERTRSEREWDRD------KVREGPRSRSRSRDRRRKERAKSKEKKSEKKEK 1201
E E + E++ +SE ++ KV + +++S +E+ KS KS +EK
Sbjct: 203 EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEK 262
Query: 1202 AQEEPPAKLLDDLFR--------KTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRK 1253
+ P +++ + + K + P+ + E AK + + K
Sbjct: 263 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGK 322
Query: 1254 EQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296
+++EE+++ KEA +E + + EK ++ ++ E + E
Sbjct: 323 GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365
Score = 39.7 bits (91), Expect = 0.020
Identities = 43/191 (22%), Positives = 79/191 (41%), Gaps = 13/191 (6%)
Query: 1119 PPPPPPVQPP-QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSR 1177
P P PV+ + P + +E+ E + +S E + K G +
Sbjct: 266 PVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQ 325
Query: 1178 SRSRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQK 1237
++ KE K +EK +K+EK ++ P K + ++ A + +T S V
Sbjct: 326 KEEEEKEVKEAPK-EEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV---TITKSVKVHL 381
Query: 1238 EAERAERAK----EREKRRKEQE---EEEQKEREKEAERERNRQLERE-KRREHSRERDR 1289
E E E K E+EK + E EEE ++ + R+ + + E + +E + +
Sbjct: 382 EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETK 441
Query: 1290 ERERERERDRG 1300
E+ RE ++G
Sbjct: 442 EKGSGREEEKG 452
Score = 37.4 bits (85), Expect = 0.098
Identities = 69/326 (21%), Positives = 114/326 (34%), Gaps = 57/326 (17%)
Query: 669 TETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVTQRLQP--- 725
T+ +D S E A + + KE ++ + +PE+ E+ V + P
Sbjct: 84 TKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKE----EEPEAEEEEVAAKKSPVKA 139
Query: 726 ----------ERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKE---EV 772
E+ + E EE E A Q E + SE+ EE E E
Sbjct: 140 TAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEA 199
Query: 773 TMDTSENRPENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKG 832
+ +E + E V E +A + + + VE EK +S +PKS +
Sbjct: 200 EGEEAEAKEEKKVEEKSEEVATK--EELVADAKVEKPEKAKSPVPKSPVEE----KGKSP 253
Query: 833 VPAGNSDTEGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHA 892
VP + +G P K S E KS +P P+ +
Sbjct: 254 VPKSPVEEKGKSPVPK----------------SPVEEKGKSPVPK-SPVEEK-------- 288
Query: 893 DDSRISEDETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQRE------EEEEEKEPEA 946
S +S+ E ++ ++ +V E +E ++E EE+ EK+ E
Sbjct: 289 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 348
Query: 947 EPPVPPQVSVEVALPPPAEHEVKKVT 972
VP + E + A EV +T
Sbjct: 349 PKDVPEKKKAESPVKEEAVAEVVTIT 374
Score = 33.5 bits (75), Expect = 1.4
Identities = 36/165 (21%), Positives = 67/165 (40%), Gaps = 21/165 (12%)
Query: 123 PNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVASL 182
P S + EE + + + +K++E E+E +EA + E+ + E PE +
Sbjct: 307 PKSPV-EEAKSKAEVGKGEQKEEE------EKEVKEAPKEEKVEKKEEKPKDVPEKKKAE 359
Query: 183 LPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEG 242
P ++ E + KS + EK ++ KP + E+ + EG
Sbjct: 360 SPVKEEAVAEVVTIT-------KSVKVHLEKETKEEGKPLQQEKEKEKAG-------GEG 405
Query: 243 SQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEE 287
E + SR + + ++ +EE E+E +E+ EEE
Sbjct: 406 GSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 82.8 bits (203), Expect = 2e-15
Identities = 126/622 (20%), Positives = 244/622 (39%), Gaps = 75/622 (12%)
Query: 55 TSRKMAELEEVTLDGKPLQALRVTDLKAA--LEQRGLAKSGQ---KSALVKRLKGALMLE 109
T+ +MAE D P++AL + A L+ + +K Q +S LVK E
Sbjct: 222 TAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATE 281
Query: 110 NLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAES 169
L KH P QPN + + ++ + + R + +R ++ E E + +E
Sbjct: 282 QLMKH--PFIRDQPNER-----------QVRIQLKDHIDRTKKKRGEKDETEYEYSGSEE 328
Query: 170 EDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSS 229
E+E +S+L +S+L R L L + +S ++ ++ + + + +R+
Sbjct: 329 EEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLL 388
Query: 230 RVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGD 289
RQ R + E + EE++ +E R + R R E+ EEE + E+E
Sbjct: 389 AERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEY-- 446
Query: 290 DEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARK 349
I ++ +EE ++ + ++++ E+ +++ LE + R Q + ++
Sbjct: 447 ----------IRRQLEEEQRQL-EILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQ 495
Query: 350 SH-----LARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR---KKASL 401
L Q+QE+ PL + + S+ P+ + E+R + S
Sbjct: 496 ERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSE-------KPAWAKEVEERSRLNRQSS 548
Query: 402 VALPEQTASEEETPPPLLTKEASSPPPHPQLHSEEEIEPMEGPAPPVLIQLSP------- 454
A+P + A+ P + PP + S ++P PP+L + P
Sbjct: 549 PAMPHKVANRISDP---------NLPPRSESFSISGVQPAR--TPPMLRPVDPQIPHLVA 597
Query: 455 --PNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAESP---AEKVPEESVLPL-VQKST 508
A T V + + + G + + + E P ++ E LP ++K
Sbjct: 598 VKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFD 657
Query: 509 LADYSAQKD----LEPESDRSAQPLPLKIEELALAKGITEECLKQPSLEQKEGRRASHTL 564
+ + Q++ P+ S P + + QP R + +
Sbjct: 658 RSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPI 717
Query: 565 LPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPLRSKQR-DVAQARTHANP 623
L S + S+ SSSS S+ SS SS+ S+ +GS + +R+ + + + H
Sbjct: 718 LESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPA 777
Query: 624 RGRPKMGSRSTSESRSRSRSRS 645
+ +P+ T SR S ++
Sbjct: 778 KVKPEESRDITRPSRPASYKKA 799
Score = 59.3 bits (142), Expect = 2e-08
Identities = 51/203 (25%), Positives = 93/203 (45%), Gaps = 27/203 (13%)
Query: 1129 QHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKER 1188
Q P EQ + +R+Q ER+ ++ ++ DR K + G +D E
Sbjct: 276 QRPATEQLMKHPFIRDQPNERQVRIQLKDHI------DRTKKKRG------EKDETEYEY 323
Query: 1189 AKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKER 1248
+ S+E++ E P+ +L+ T + Q+ KE A R ++
Sbjct: 324 SGSEEEEEEN----DSGEPSSILNLPGESTLRRDFLRL------QLANKERSEALRRQQL 373
Query: 1249 EKRRKEQEEEEQK---EREK--EAERERNRQLEREKRREHSRERDRERERERERDRGDRD 1303
E++++E EE +++ ER+K E ++E+ R+LE ++RRE + +ERE+ R + R
Sbjct: 374 EQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRR 433
Query: 1304 RDRERDRERGRERDRRDTKRHSR 1326
+ R E +E RR + R
Sbjct: 434 EEERRRAEHEQEYIRRQLEEEQR 456
Score = 51.2 bits (121), Expect = 7e-06
Identities = 55/250 (22%), Positives = 102/250 (40%), Gaps = 49/250 (19%)
Query: 1118 HPPPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWD----------- 1166
H P Q +HP + ER VR Q + +++ + E E++
Sbjct: 274 HSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEEN 333
Query: 1167 ------------------RDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQEEPPA 1208
RD +R ++ RS RR++ + + + E K + E
Sbjct: 334 DSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQK 393
Query: 1209 KLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAE 1268
++ + ++ + L + Q +KE + + ERE+RR +E+ ++E + AE
Sbjct: 394 RIEEQKEQRRR---------LEEQQRREKELRKQQ---EREQRRHYEEQMRREEERRRAE 441
Query: 1269 RERN---RQLEREKRREHSRERDRERER----ERERDRGDRDRDRER-DRERGRERDRRD 1320
E+ RQLE E+R+ ++ E+ E +R + + R ER R+ +ERD
Sbjct: 442 HEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLV 501
Query: 1321 TKRHSRSRSR 1330
+ +H R R
Sbjct: 502 SLQHQRQEQR 511
Score = 41.2 bits (95), Expect = 0.007
Identities = 49/249 (19%), Positives = 99/249 (39%), Gaps = 40/249 (16%)
Query: 1088 EQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQERAV---RE 1144
E+DE +Y E + + G P + P R + +ER+ R+
Sbjct: 315 EKDETEYEYS---GSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQ 371
Query: 1145 QWAEREREMERRERTR-SEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKEKAQ 1203
Q +++RE E +R +ER+ ++ E R R +++R+E+ K+++ E++ +
Sbjct: 372 QLEQQQRENEEHKRQLLAERQ---KRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYE 428
Query: 1204 EEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREK-RRKEQEEEEQKE 1262
E+ +++E ER E+E RR+ +EE+ Q E
Sbjct: 429 EQ-----------------------------MRREEERRRAEHEQEYIRRQLEEEQRQLE 459
Query: 1263 REKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRDTK 1322
++ L KR++ +R ER + + + D + R+ R +++
Sbjct: 460 ILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLY 519
Query: 1323 RHSRSRSRS 1331
+ S S
Sbjct: 520 HYKEGMSPS 528
Score = 37.4 bits (85), Expect = 0.098
Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 4/82 (4%)
Query: 1260 QKEREKEAERERNRQLEREKR--REHSRERDRERERERERDRGDRDR--DRERDRERGRE 1315
Q ++ +E R +QLE+++R EH R+ ER++ E + R R +++R + R+
Sbjct: 358 QLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRK 417
Query: 1316 RDRRDTKRHSRSRSRSTPVRDR 1337
+ R+ +RH + R R R
Sbjct: 418 QQEREQRRHYEEQMRREEERRR 439
Score = 34.3 bits (77), Expect = 0.83
Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 8/143 (5%)
Query: 1135 QREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERA---KS 1191
+++QER R + E+ R E R R E+E+ R ++ E R + + E+A +
Sbjct: 416 RKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEY 475
Query: 1192 KEKKSEKKEKA-----QEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAK 1246
K K+ E++ +A Q + L L + + + PL + +E+ AK
Sbjct: 476 KRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAK 535
Query: 1247 EREKRRKEQEEEEQKEREKEAER 1269
E E+R + + K A R
Sbjct: 536 EVEERSRLNRQSSPAMPHKVANR 558
Score = 34.3 bits (77), Expect = 0.83
Identities = 39/133 (29%), Positives = 51/133 (38%), Gaps = 33/133 (24%)
Query: 191 LERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLSEGS-----QP 245
LE P S S SS+ S + +P S R R RA SEGS +P
Sbjct: 718 LESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTR-VRANSKSEGSPVLPHEP 776
Query: 246 A----EEEEDQETPSR--------------------NLRVR-ADRNLK--TEEEEEEEEE 278
A EE D PSR LR+ +R +K T+ EE
Sbjct: 777 AKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEES 836
Query: 279 EEEDDEEEEGDDE 291
E ++EEE+G+ E
Sbjct: 837 ESSEEEEEDGESE 849
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.304 0.123 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,257,824
Number of Sequences: 37866
Number of extensions: 3626257
Number of successful extensions: 135124
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1457
Number of HSP's successfully gapped in prelim test: 2083
Number of HSP's that attempted gapping in prelim test: 27847
Number of HSP's gapped (non-prelim): 43998
length of query: 1341
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1227
effective length of database: 13,930,794
effective search space: 17093084238
effective search space used: 17093084238
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.