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Search of human proteins with 7661700
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
(816 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 1641 0.0
gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo s... 1342 0.0
gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo s... 1271 0.0
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 1159 0.0
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 1124 0.0
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 1123 0.0
gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo s... 912 0.0
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 408 e-113
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ... 404 e-112
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ... 400 e-111
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ... 399 e-111
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ... 375 e-104
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ... 375 e-103
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ... 297 3e-80
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s... 297 3e-80
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ... 284 2e-76
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s... 275 1e-73
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 115 2e-25
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 112 1e-24
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 107 4e-23
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 95 3e-19
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 92 1e-18
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens] 84 7e-16
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 83 9e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 83 9e-16
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens] 82 3e-15
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 81 4e-15
gi|39930351 dynamin binding protein [Homo sapiens] 80 6e-15
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 80 1e-14
gi|11321634 CD2-associated protein [Homo sapiens] 79 2e-14
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 1641 bits (4250), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSS 120
TRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSS
Sbjct: 61 TRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSS 120
Query: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP
Sbjct: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
Query: 181 PHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDS 240
PHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDS
Sbjct: 181 PHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDS 240
Query: 241 SPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVS 300
SPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVS
Sbjct: 241 SPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVS 300
Query: 301 ERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSK 360
ERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSK
Sbjct: 301 ERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSK 360
Query: 361 DWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATL 420
DWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATL
Sbjct: 361 DWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATL 420
Query: 421 PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 480
PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT
Sbjct: 421 PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 480
Query: 481 PEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP 540
PEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP
Sbjct: 481 PEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRP 540
Query: 541 SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGD 600
SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 541 SSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGD 600
Query: 601 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 660
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 601 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 660
Query: 661 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 720
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 661 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 720
Query: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 780
DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD
Sbjct: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 780
Query: 781 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 781 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
>gi|78000163 sorbin and SH3 domain containing 1 isoform 3 [Homo
sapiens]
Length = 1292
Score = 1342 bits (3474), Expect = 0.0
Identities = 731/966 (75%), Positives = 737/966 (76%), Gaps = 219/966 (22%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 88
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 89 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 148
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 149 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 208
TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 209 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 268
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 269 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 328
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 329 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD------------ 376
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRD
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPEENPYFPTYK 420
Query: 377 ----------------------------------DDSDLYSPRYSFSEDTKSPLSVPRSK 402
DDSDLYSPRYSFSEDTKSPLSVPRSK
Sbjct: 421 FPELPEIQQTSEEDNPYTPTYQFPASTPSPKSEDDDSDLYSPRYSFSEDTKSPLSVPRSK 480
Query: 403 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP-------- 454
SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEP
Sbjct: 481 SEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQP 540
Query: 455 -----------------------------------------KSIYEYQPGKSSVL----- 468
K I++Y PG S+L
Sbjct: 541 GKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWDYTPGDCSILPREDR 600
Query: 469 -TN----------------EKM-------------SSAISPTPEISSETPGYIYSSNFHA 498
TN EKM SSAISPTPEISSETPGYIYSSNFHA
Sbjct: 601 KTNLDKDLSLCQTELEADLEKMETLNKAPSANVPQSSAISPTPEISSETPGYIYSSNFHA 660
Query: 499 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 558
VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA
Sbjct: 661 VKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA 720
Query: 559 DYLESTEEFIR---------------------------RRH------------------- 572
DYLESTEEFIR RRH
Sbjct: 721 DYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDL 780
Query: 573 ---DD-------KEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 622
DD EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG
Sbjct: 781 LNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVG 840
Query: 623 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 682
IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV
Sbjct: 841 IFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 900
Query: 683 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 742
DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ +
Sbjct: 901 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQF-SSH 959
Query: 743 QRRVTP 748
+ +TP
Sbjct: 960 SKLITP 965
Score = 170 bits (430), Expect = 6e-42
Identities = 80/80 (100%), Positives = 80/80 (100%)
Query: 737 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 796
QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT
Sbjct: 1213 QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGT 1272
Query: 797 SRRTKQFGTFPGNYVKPLYL 816
SRRTKQFGTFPGNYVKPLYL
Sbjct: 1273 SRRTKQFGTFPGNYVKPLYL 1292
Score = 34.3 bits (77), Expect = 0.48
Identities = 93/457 (20%), Positives = 153/457 (33%), Gaps = 118/457 (25%)
Query: 187 PHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDL---RRVSEPDLTGAVSSTDSSPL 243
P S P+R++ + P FS L+ PAP L RR P++ S
Sbjct: 941 PFSSSPSRSATA-------SPQFSSHSKLITPAPSSLPHSRRALSPEMHAVTS------- 986
Query: 244 LNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLS----SLSDPV 299
E S +G + +++ P P +I N + L LS S SD
Sbjct: 987 --EWISLTVGVPGRRSLALTPPLPPLPEASIYNTDHLALSPRASPSLSLSLPHLSWSDRP 1044
Query: 300 SERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERS 359
+ R V + P+ K T L+ S
Sbjct: 1045 TPRSVASPLALPSPHK----------------------TYSLAPTSQAS----------- 1071
Query: 360 KDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSAT 419
L+ + D +++P +D+ L + S S +S + + +S
Sbjct: 1072 -------------LHMNGDGGVHTPSSGIHQDSFLQLPLGSSDSVISQLS-DAFSSQSKR 1117
Query: 420 LPLPARSSSLKSSSERNDWE--PPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAI 477
P S + +ER E P K+ ++K +P + L+ E+ S +
Sbjct: 1118 QPWREESGQYERKAERGAGERGPGGPKI-SKKSCLKPSDVVR-------CLSTEQRLSDL 1169
Query: 478 SPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGL 537
+ TPE S PG S F + E + ER GG+ +G
Sbjct: 1170 N-TPEESR--PGKPLGSAFPGSEAE-----------QTERH------RGGE-----QAGR 1204
Query: 538 KRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQ 597
K S + R P R +++ +A + + Q EL L+
Sbjct: 1205 KAARRGGSQQPQAQQRRVTPD-----------RSQTSQDLFSYQALYSYIPQNDDELELR 1253
Query: 598 KGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIELL 632
GDIV + ++ D W+ G + G FP Y++ L
Sbjct: 1254 DGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 1290
Score = 32.7 bits (73), Expect = 1.4
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 750 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 809
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 788 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 845
Query: 810 YVKPL 814
Y++ L
Sbjct: 846 YIELL 850
Score = 32.0 bits (71), Expect = 2.4
Identities = 17/72 (23%), Positives = 35/72 (48%), Gaps = 3/72 (4%)
Query: 637 KAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPG 693
+AQ +++TP + + A +++ E+ R G+ + ++ + D+ W+ G
Sbjct: 1216 QAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRR 1275
Query: 694 TSRQGIFPITYV 705
T + G FP YV
Sbjct: 1276 TKQFGTFPGNYV 1287
>gi|78000167 sorbin and SH3 domain containing 1 isoform 5 [Homo
sapiens]
Length = 905
Score = 1271 bits (3289), Expect = 0.0
Identities = 703/974 (72%), Positives = 712/974 (73%), Gaps = 227/974 (23%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 88
PTKICTGKGAVTLRASSSYRETPSSS P+S E R S
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSS-------------------PASPQETRQHESKPG 101
Query: 89 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 148
+P +A +R S A ++ AQP + Y
Sbjct: 102 ---LEPEPSSADEWRL---------SSSADANGNAQPSSLAAKGYR-------------- 135
Query: 149 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 208
P +P+ S QRWPHHSQPARASGSFAPISQTPPS
Sbjct: 136 ------SVHPNLPSDKS------------------QRWPHHSQPARASGSFAPISQTPPS 171
Query: 209 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 268
FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA
Sbjct: 172 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 231
Query: 269 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 328
YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK
Sbjct: 232 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 291
Query: 329 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSF 388
DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSF
Sbjct: 292 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSF 351
Query: 389 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 448
SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR
Sbjct: 352 SEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTR 411
Query: 449 KYRAEPKSIYEYQPGKSSVLTNEKMS---------------------------------- 474
KYRAEPKSIYEYQPGKSSVLTNEKMS
Sbjct: 412 KYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPWYKFFSELEFGKPPPKKIWD 471
Query: 475 ----------------SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQ 518
SAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQ
Sbjct: 472 YTPGDCSILPREDRKSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQ 531
Query: 519 IYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR--------- 569
IYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 532 IYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKL 591
Query: 570 ------------------RRH----------------------DD-------KEMRPARA 582
RRH DD EMRPARA
Sbjct: 592 LADQRRLKREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARA 651
Query: 583 KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 642
KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK
Sbjct: 652 KFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKK 711
Query: 643 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 702
LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI
Sbjct: 712 LTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPI 771
Query: 703 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ--------------------QPQAQ 742
TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ QPQAQ
Sbjct: 772 TYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQLSHHSLRAGPDLTESEKSYVQPQAQ 831
Query: 743 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 802
QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ
Sbjct: 832 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 891
Query: 803 FGTFPGNYVKPLYL 816
FGTFPGNYVKPLYL
Sbjct: 892 FGTFPGNYVKPLYL 905
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 1159 bits (2999), Expect = 0.0
Identities = 579/580 (99%), Positives = 579/580 (99%)
Query: 237 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 296
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
Query: 297 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 356
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
Query: 357 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 416
ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR
Sbjct: 225 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 284
Query: 417 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 476
SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA
Sbjct: 285 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 344
Query: 477 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 536
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 345 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 404
Query: 537 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPL 596
LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPL
Sbjct: 405 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPL 464
Query: 597 QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA 656
QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA
Sbjct: 465 QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA 524
Query: 657 KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 716
KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP
Sbjct: 525 KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNP 584
Query: 717 VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL 776
VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL
Sbjct: 585 VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELEL 644
Query: 777 RDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
RDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 645 RDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 684
Score = 254 bits (648), Expect = 3e-67
Identities = 233/756 (30%), Positives = 342/756 (45%), Gaps = 128/756 (16%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQE 60
Query: 61 TRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSS 120
TRQHESKP DEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD++
Sbjct: 61 TRQHESKP---------DEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDSS-- 109
Query: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
P + V L+ TD P++ +SA +P+ P
Sbjct: 110 ----PLLNEVSSSLIGTDS---------------QAFPSVSKPSSA-----YPSTTIVNP 145
Query: 181 PHLQRWPHHSQPARASGSFAPISQ--TPPSFSPPPPLVPPAP-EDLRRVSEPDLTGAVSS 237
+ + Q R S P+S+ S P P +P + + + ++ D V S
Sbjct: 146 TIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKS 205
Query: 238 TDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSD 297
T L++VS +G + ++ S + T + + NR+ SD
Sbjct: 206 TQD---LSDVSMDEVGIPLRN----TERSKDWYKTMFKQ----IHKLNRDDD------SD 248
Query: 298 PVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTE 357
S R +D+ + P S ++ + + D +VVK + L + L+++
Sbjct: 249 LYSPRYSFSEDT----KSPLSVPRSKSEMSYIDGEKVVKRSATL---PLPARSSSLKSSS 301
Query: 358 RSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRS 417
DW K + R + + Y + S L+ + S +S + S
Sbjct: 302 ERNDWEPPDKKVDTRKYRAEPKSI----YEYQPGKSSVLTNEKMSSAIS-----PTPEIS 352
Query: 418 ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAI 477
+ P SS+ + +D P D R KS+ E L+ K S+
Sbjct: 353 SETPGYIYSSNFHAVKRESDGAPGD-LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSS 411
Query: 478 SPTPEISSETPGYIYSSNF-----HAVKRESDG---APGDLTSLENERQIYKSVLEGGDI 529
+ T + SE+P + +++ ++R D P + + + L+ GDI
Sbjct: 412 ASTKD--SESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDI 469
Query: 530 PLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRP--------AR 581
+ K+ + + P Y+E + K++ P A
Sbjct: 470 ----VYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP--AEKAQPKKLTPVQVLEYGEAI 523
Query: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------- 632
AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 524 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKN 583
Query: 633 --------------------PPAEKAQPKKLTPVQVLEYGEAI---AKFNFNGDTQVEMS 669
P +AQ +++TP + + A +++ E+
Sbjct: 584 PVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELE 643
Query: 670 FRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
R G+ + ++ + D+ W+ G T + G FP YV
Sbjct: 644 LRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV 679
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 1124 bits (2908), Expect = 0.0
Identities = 611/798 (76%), Positives = 629/798 (78%), Gaps = 80/798 (10%)
Query: 82 LSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQD-ATSSSAAQPEVIVVPLYLVNTDRG 140
+SS D A + LA P QD AT+ + V + V T +
Sbjct: 1 MSSECDGGSKAVMNGLA-----------PGSNGQDKATADPLRARSISAVKIIPVKTVKN 49
Query: 141 QEGTARPPTPLGPL------GCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPAR 194
G P T + P G V +++ +P + P H + +P+
Sbjct: 50 ASGLVLP-TDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSS 108
Query: 195 ASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGT 254
A S + P L A + R V P+L S DSSPLLNEVSSSLIGT
Sbjct: 109 ADEWRLSSSADANGNAQPSSL---AAKGYRSV-HPNLPSD-KSQDSSPLLNEVSSSLIGT 163
Query: 255 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 314
DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE
Sbjct: 164 DSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQE 223
Query: 315 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 374
KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN
Sbjct: 224 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 283
Query: 375 RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE 434
RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE
Sbjct: 284 RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE 343
Query: 435 RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS 494
RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS
Sbjct: 344 RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS 403
Query: 495 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 554
NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH
Sbjct: 404 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 463
Query: 555 FIPADYLESTEEFIR---------------------------RRH--------------- 572
FIPADYLESTEEFIR RRH
Sbjct: 464 FIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAARRHTGVIPTHHQFITNER 523
Query: 573 -------DD-------KEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH 618
DD EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH
Sbjct: 524 FGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHH 583
Query: 619 GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 678
GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL
Sbjct: 584 GRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 643
Query: 679 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ 738
LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ
Sbjct: 644 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ 703
Query: 739 PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR 798
PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR
Sbjct: 704 PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR 763
Query: 799 RTKQFGTFPGNYVKPLYL 816
RTKQFGTFPGNYVKPLYL
Sbjct: 764 RTKQFGTFPGNYVKPLYL 781
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 1123 bits (2905), Expect = 0.0
Identities = 578/636 (90%), Positives = 578/636 (90%), Gaps = 56/636 (8%)
Query: 237 STDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 296
S DSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS
Sbjct: 105 SQDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLS 164
Query: 297 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 356
DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT
Sbjct: 165 DPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNT 224
Query: 357 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 416
ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR
Sbjct: 225 ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKR 284
Query: 417 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 476
SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA
Sbjct: 285 SATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSA 344
Query: 477 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 536
ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG
Sbjct: 345 ISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSG 404
Query: 537 LKRPSSSASTKDSESPRHFIPADYLESTEEFIR--------------------------- 569
LKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 405 LKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRLKREQEEADIAA 464
Query: 570 RRH----------------------DD-------KEMRPARAKFDFKAQTLKELPLQKGD 600
RRH DD EMRPARAKFDFKAQTLKELPLQKGD
Sbjct: 465 RRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQTLKELPLQKGD 524
Query: 601 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 660
IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF
Sbjct: 525 IVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNF 584
Query: 661 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 720
NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM
Sbjct: 585 NGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYM 644
Query: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 780
DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD
Sbjct: 645 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGD 704
Query: 781 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 705 IVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 740
>gi|78000165 sorbin and SH3 domain containing 1 isoform 4 [Homo
sapiens]
Length = 1151
Score = 912 bits (2357), Expect = 0.0
Identities = 563/988 (56%), Positives = 603/988 (61%), Gaps = 262/988 (26%)
Query: 1 MSSECDGGSKAVMNGLAPGSNGQDK--------------------------------DMD 28
MSSECDGGSKAVMNGLAPGSNGQDK DMD
Sbjct: 1 MSSECDGGSKAVMNGLAPGSNGQDKATADPLRARSISAVKIIPVKTVKNASGLVLPTDMD 60
Query: 29 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 88
PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA
Sbjct: 61 PTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADA 120
Query: 89 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 148
NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP
Sbjct: 121 NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPP 180
Query: 149 TPLGPLGCVPTI-------------------------------PATASAA------SPLT 171
TPLGPLGCVPTI PA AS + +P +
Sbjct: 181 TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPS 240
Query: 172 FPTLDDFIPPHLQRWPHHSQP----ARASGSFAPI------------SQTPPSFSPPPPL 215
F +PP + S+P A +S +P+ SQ PS S P
Sbjct: 241 FSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSA 300
Query: 216 VPPAP----------------EDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAF 259
P + L +S+P V DS+P + +S + +A
Sbjct: 301 YPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAK 360
Query: 260 PS---VSKPSSAYPSTTIVNPTIVLLQHNREQQ------KRLSSLSDPVSERRVGEQDSA 310
V K + ++ I L R + K++ L+ E E
Sbjct: 361 DDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDTPE----ENPYF 416
Query: 311 PTQEKPTSPGKAIEKRAKDDSRRVVKSTQ-DLSDVSMDEVGIPLRNTERSKDWYKTMFKQ 369
PT + P P I++ +++ V S + + S + + L ++ T Q
Sbjct: 417 PTYKFPELP--EIQQTSEETKSCSVMSPRLECSGTVIAHCSLKLLDSSNPP----TSASQ 470
Query: 370 IHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSL 429
+ DDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSL
Sbjct: 471 VAG-TADDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSL 529
Query: 430 KSSSERNDWEPPDKKVDTRKYRAEP----------------------------------- 454
KSSSERNDWEPPDKKVDTRKYRAEP
Sbjct: 530 KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSRDISPEEIDLKNEPW 589
Query: 455 --------------KSIYEYQPGKSSVL------TN----------------EKM----- 473
K I++Y PG S+L TN EKM
Sbjct: 590 YKFFSELEFGKPPPKKIWDYTPGDCSILPREDRKTNLDKDLSLCQTELEADLEKMETLNK 649
Query: 474 --------SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLE 525
SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLE
Sbjct: 650 APSANVPQSSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLE 709
Query: 526 GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR---------------- 569
GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIR
Sbjct: 710 GGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEKLLADQRRL 769
Query: 570 -----------RRH----------------------DD-------KEMRPARAKFDFKAQ 589
RRH DD EMRPARAKFDFKAQ
Sbjct: 770 KREQEEADIAARRHTGVIPTHHQFITNERFGDLLNIDDTAKRKSGSEMRPARAKFDFKAQ 829
Query: 590 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVL 649
TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVL
Sbjct: 830 TLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVL 889
Query: 650 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 709
EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK
Sbjct: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Query: 710 RPLVKNPVDYMDLPFSSSPSRSATASPQ 737
RPLVKNPVDYMDLPFSSSPSRSATASPQ
Sbjct: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQ 977
Score = 196 bits (498), Expect = 7e-50
Identities = 120/271 (44%), Positives = 146/271 (53%), Gaps = 39/271 (14%)
Query: 576 EMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELLP 633
E A AKF+F T E+ +KG+ + + +Q+D+NWYEG G R GIFP TY++++
Sbjct: 890 EYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIK 949
Query: 634 ------PAE------KAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERI----- 676
P + + P + + E ++ + G +I
Sbjct: 950 RPLVKNPVDYMDLPFSSSPSRSATASPQPWREESGQYERKAERGAGERGPGGPKISKKSC 1009
Query: 677 -----------TLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFS 725
T R D N E PG FP + + +R
Sbjct: 1010 LKPSDVVRCLSTEQRLSDLNTPEESRPGKPLGSAFPGSEAEQTERHRGGE---------Q 1060
Query: 726 SSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 785
+ + QQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM
Sbjct: 1061 AGRKAARRGGSQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVM 1120
Query: 786 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL
Sbjct: 1121 EKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 1151
Score = 33.1 bits (74), Expect = 1.1
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 570 RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 627
R +++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 1085 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 1144
Query: 628 YIELL 632
Y++ L
Sbjct: 1145 YVKPL 1149
Score = 32.7 bits (73), Expect = 1.4
Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 2/65 (3%)
Query: 750 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGN 809
+ ++ ++ +A + + Q EL L+ GDIV + ++ D W+ G + G FP
Sbjct: 810 KRKSGSEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRT 867
Query: 810 YVKPL 814
Y++ L
Sbjct: 868 YIELL 872
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 408 bits (1048), Expect = e-113
Identities = 233/492 (47%), Positives = 311/492 (63%), Gaps = 34/492 (6%)
Query: 352 PLRNTERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----LSVPRSKSEM- 405
PL+ +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P S P +K++
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTY 65
Query: 406 -----SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPPDKKVDTRKYR 451
S+ D + A+ P+P +SS+E++DW+PPD+KVDTRK+R
Sbjct: 66 RPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFR 125
Query: 452 AEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGD 509
+EP+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 126 SEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGP 184
Query: 510 LTSLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLES 563
L ++ S L G L PSS + KD ESPR + D S
Sbjct: 185 PRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRS 244
Query: 564 TEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGI 623
RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGI
Sbjct: 245 APRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGI 303
Query: 624 FPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 682
FP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++V
Sbjct: 304 FPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRV 363
Query: 683 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 742
D+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S + Q
Sbjct: 364 DQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQ 422
Query: 743 QRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQ 802
+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK
Sbjct: 423 RPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKF 480
Query: 803 FGTFPGNYVKPL 814
FGTFPGNYVK L
Sbjct: 481 FGTFPGNYVKRL 492
>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
sapiens]
Length = 644
Score = 404 bits (1039), Expect = e-112
Identities = 264/610 (43%), Positives = 343/610 (56%), Gaps = 42/610 (6%)
Query: 225 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 284
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
Query: 285 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 344
Q S S + D + P EKR V+K+
Sbjct: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Query: 345 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSP 395
+DE GIP +R T +R KDWYKTMFKQIH +++ LY+P YS T P
Sbjct: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRP 219
Query: 396 LSVPRS-KSEMSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAE 453
LS S S ++ D V P+P +SS+E++DW+PPD+KVDTRK+R+E
Sbjct: 220 LSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSE 279
Query: 454 PKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLT 511
P+SI+EY+PGKSS+L +E+ +S + + S E P +S+F +R+S+ A G
Sbjct: 280 PRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPR 338
Query: 512 SLENERQIYKSV----LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPA--DYLESTE 565
L ++ S L G L PSS + KD ESPR + D S
Sbjct: 339 GLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAP 398
Query: 566 EFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP 625
RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP
Sbjct: 399 RE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFP 457
Query: 626 RTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDE 684
+Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+
Sbjct: 458 ISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQ 517
Query: 685 NWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQR 744
NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S + Q+
Sbjct: 518 NWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRP 576
Query: 745 RVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFG 804
T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FG
Sbjct: 577 VFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFG 634
Query: 805 TFPGNYVKPL 814
TFPGNYVK L
Sbjct: 635 TFPGNYVKRL 644
Score = 84.0 bits (206), Expect = 5e-16
Identities = 162/694 (23%), Positives = 244/694 (35%), Gaps = 141/694 (20%)
Query: 74 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVV 130
P SA WR + + NG+A SSLAAKG+RSV PNL QD S + +Q V
Sbjct: 27 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNL-----QDKRSPTQSQITV--- 76
Query: 131 PLYLVNTDRGQEGTARPP-----TPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQR 185
G G A P P P ++PA+ +++ + T D
Sbjct: 77 --------NGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVMQHGTSLD----STDT 122
Query: 186 WPHHSQPA-RASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLL 244
+P H+Q + S P+ ++ + P + V E + A+ +T P
Sbjct: 123 YPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRP-- 180
Query: 245 NEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRV 304
T + V KP + NP H + + LS S+
Sbjct: 181 ----KDWYKTMFKQIHMVHKPG-------LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 229
Query: 305 GEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYK 364
A + P + D K D D +D T + + +
Sbjct: 230 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVD--------TRKFRSEPR 281
Query: 365 TMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPA 424
++F+ Y P S + P S+ +S + S L P
Sbjct: 282 SIFE-------------YEPGKSSILQHERPASLYQSSIDRS-------------LERPM 315
Query: 425 RSSSLKSSSERNDWE-----PPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISP 479
S+S+ S + PP D R P + PG S+ LT SS+ S
Sbjct: 316 SSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRV--DLPGSSTTLTKSFTSSSPSS 373
Query: 480 TPEISSETPGYIYSSNF----HAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLS 535
YSS + RE G P E E+ K+V + + LS
Sbjct: 374 PSRAKDRESPRSYSSTLTDMGRSAPRERRGTP------EKEKLPAKAVYDFKAQTSKELS 427
Query: 536 GLKRPSSSASTKDS----ESPRH----FIPADYLESTEEFIRRR-------HDDKEMRPA 580
K + K E H P Y+E + + E+ A
Sbjct: 428 FKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEA 487
Query: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL------ 632
AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++
Sbjct: 488 IAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKG 547
Query: 633 ------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFR 671
PP + K Q T + GE A +N+ + E+ R
Sbjct: 548 AEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELR 607
Query: 672 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
+ + I ++ + D+ W+ G T G FP YV
Sbjct: 608 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 641
>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
sapiens]
Length = 666
Score = 400 bits (1028), Expect = e-111
Identities = 266/676 (39%), Positives = 358/676 (52%), Gaps = 97/676 (14%)
Query: 217 PPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVN 276
P + + R V P+L S T S +N S + S S SAY +N
Sbjct: 10 PDSAKGFRSV-RPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLN 66
Query: 277 PTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVK 336
+IV+ Q S S + D + P EKR V+K
Sbjct: 67 SSIVM-------QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIK 114
Query: 337 STQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDT 392
+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++
Sbjct: 115 APHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGL 174
Query: 393 KSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSS 433
+P S P +K++ S+ D + A+ P+P +SS+
Sbjct: 175 YNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSST 234
Query: 434 ERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYS 493
E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ + I+P P Y +
Sbjct: 235 EKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPTDRINPDDIDLENEPWYKFF 294
Query: 494 SNFH----AVKRESDGAPGDLTSLENERQIYKSVLEG----------------------- 526
S K+ D + + NE +Y+S ++
Sbjct: 295 SELEFGRPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 354
Query: 527 ------------------GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIPA--D 559
G + L G S PSS + KD ESPR + D
Sbjct: 355 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTD 414
Query: 560 YLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG 619
S RR +KE PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHG
Sbjct: 415 MGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHG 473
Query: 620 RVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITL 678
RVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ L
Sbjct: 474 RVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVIL 533
Query: 679 LRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ 738
L++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P S S S
Sbjct: 534 LKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSS 592
Query: 739 PQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSR 798
+ Q+ T + Q + F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSR
Sbjct: 593 NKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSR 650
Query: 799 RTKQFGTFPGNYVKPL 814
RTK FGTFPGNYVK L
Sbjct: 651 RTKFFGTFPGNYVKRL 666
Score = 60.5 bits (145), Expect = 6e-09
Identities = 125/570 (21%), Positives = 202/570 (35%), Gaps = 143/570 (25%)
Query: 190 SQPARASGSFAPISQTPPSFSP---------------PPPLVPPAPEDLRRVSEPDLTGA 234
S PA + ++ P+S++ SP PPP+ P P D + D
Sbjct: 183 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 242
Query: 235 VSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSS 294
D+ +E S + P S T +NP + L+ N K S
Sbjct: 243 DRKVDTRKFRSEPRSIF-----EYEPGKSSILQHERPTDRINPDDIDLE-NEPWYKFFSE 296
Query: 295 LSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLR 354
L + P +KP + QD S +E +
Sbjct: 297 L-----------EFGRPPPKKP------------------LDYVQDHSSGVFNEASLYQS 327
Query: 355 NTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVV 414
+ +RS L R S + + ++ + PR + S
Sbjct: 328 SIDRS-------------LERPMSSASMASDFRKRRKSEPAVGPPRGLGDQS-------- 366
Query: 415 KRSATLP----LPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTN 470
S T P LP S++L S + P + D R P+S SS LT+
Sbjct: 367 -ASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKD----RESPRSY-------SSTLTD 414
Query: 471 EKMSSAIS--PTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSLENERQIYKSVLEG- 526
S+ TPE +Y +F A +E GD + R+I ++ EG
Sbjct: 415 MGRSAPRERRGTPEKEKLPAKAVY--DFKAQTSKELSFKKGDTVYI--LRKIDQNWYEGE 470
Query: 527 --GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKF 584
G + + +S +++ + + + P P + E+ ++
Sbjct: 471 HHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKY----------------- 513
Query: 585 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIELL---------- 632
+F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E++
Sbjct: 514 NFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDY 573
Query: 633 --PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDTQVEMSFRKGER 675
PP + K Q T + GE A +N+ + E+ R+ +
Sbjct: 574 PDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDV 633
Query: 676 ITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
I ++ + D+ W+ G T G FP YV
Sbjct: 634 IDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 663
>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
sapiens]
Length = 661
Score = 399 bits (1024), Expect = e-111
Identities = 260/641 (40%), Positives = 349/641 (54%), Gaps = 70/641 (10%)
Query: 225 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 284
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 40 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 94
Query: 285 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 344
Q S S + D + P EKR V+K+
Sbjct: 95 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 145
Query: 345 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----L 396
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P
Sbjct: 146 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 205
Query: 397 SVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPP 441
S P +K++ S+ D + A+ P+P +SS+E++DW+PP
Sbjct: 206 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 265
Query: 442 DKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAV-- 499
D+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ P + + G ++ +
Sbjct: 266 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPK-KPLDYVQDHSSGVFNEASLYQSSI 324
Query: 500 -------------------KRESDGAPGDLTSLENERQIYKSV----LEGGDIPLQGLSG 536
+R+S+ A G L ++ S L G L
Sbjct: 325 DRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFT 384
Query: 537 LKRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKEL 594
PSS + KD ESPR + D S RR +KE PA+A +DFKAQT KEL
Sbjct: 385 SSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKEL 443
Query: 595 PLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGE 653
+KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GE
Sbjct: 444 SFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGE 503
Query: 654 AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
AIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+
Sbjct: 504 AIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-T 562
Query: 714 KNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDE 773
K DY D P S S S + Q+ T + Q + F QALY+Y P+N+DE
Sbjct: 563 KGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDE 620
Query: 774 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
LELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 621 LELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 661
Score = 85.9 bits (211), Expect = 1e-16
Identities = 161/701 (22%), Positives = 261/701 (37%), Gaps = 121/701 (17%)
Query: 74 PSSADEWRLSSSADA---NGNAQPSSLAAKGYRSVHPNLPSDKSQ-------DATSSSAA 123
P SA WR + + NG+A SSLAAKG+RSV PNL +S + S A
Sbjct: 10 PDSA--WRSYNDGNQETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITVNGNSGGAV 67
Query: 124 ----------QPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFP 173
P +P L ++ Q GT+ T P ++ T S++ PL +
Sbjct: 68 SPMSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQH-AQSLDGTTSSSIPL-YR 125
Query: 174 TLDDFIPPHLQRWPHHS--QPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDL 231
+ ++ + + PH+ P SG I T P + + V +PD
Sbjct: 126 SSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTT---VDRPKDWYKTMFKQIHMVHKPD- 181
Query: 232 TGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKR 291
D + + N + G + + + S P++ T P + H+
Sbjct: 182 -------DDTDMYNTPYTYNAGLYNPPYSAQSHPAA---KTQTYRP--LSKSHSDNSPNA 229
Query: 292 LSSLSDPVSERRV-------GEQDSAPTQEKPTSP--GKAIEKRAKDDSRRVVKSTQDLS 342
S PV V +D + T++ P K ++ + + R + + S
Sbjct: 230 FKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKS 289
Query: 343 DVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS---FSEDTKSPLSVP 399
+ E P + + +D +F + D L P S S+ K S P
Sbjct: 290 SILQHERPPPKKPLDYVQDHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEP 349
Query: 400 RSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYE 459
D + LP S++L S + P + D R P+S
Sbjct: 350 AVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKD----RESPRSY-- 403
Query: 460 YQPGKSSVLTNEKMSSAIS--PTPEISSETPGYIYSSNFHA-VKRESDGAPGDLTSLENE 516
SS LT+ S+ TPE +Y +F A +E GD +
Sbjct: 404 -----SSTLTDMGRSAPRERRGTPEKEKLPAKAVY--DFKAQTSKELSFKKGDTVYI--L 454
Query: 517 RQIYKSVLEG---GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHD 573
R+I ++ EG G + + +S +++ + + + P P
Sbjct: 455 RKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPG--------------- 499
Query: 574 DKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHG--RVGIFPRTYIEL 631
E+ A AK++F A T EL L+KGD V + K++DQNWYEG+ G R GIFP +Y+E+
Sbjct: 500 --EIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEV 557
Query: 632 L------------PP--------------AEKAQPKKLTPVQVLEYGEAI-AKFNFNGDT 664
+ PP + K Q T + GE A +N+
Sbjct: 558 VKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRN 617
Query: 665 QVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
+ E+ R+ + I ++ + D+ W+ G T G FP YV
Sbjct: 618 EDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 658
>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
sapiens]
Length = 731
Score = 375 bits (963), Expect = e-104
Identities = 262/697 (37%), Positives = 356/697 (51%), Gaps = 129/697 (18%)
Query: 225 RVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQH 284
R P+L S T S +N S + S S SAY +N +IV+
Sbjct: 57 RSVRPNLQDKRSPTQSQITVNGNSGGAVSPMSYYQRPFSP--SAYSLPASLNSSIVM--- 111
Query: 285 NREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDV 344
Q S S + D + P EKR V+K+
Sbjct: 112 ----QHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVT-----VIKAPHYPGIG 162
Query: 345 SMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDSDLYSPRYSFSEDTKSP----L 396
+DE GIP +R T +R KDWYKTMFKQIH +++ DDD+D+Y+ Y+++ +P
Sbjct: 163 PVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQ 222
Query: 397 SVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL---------KSSSERNDWEPP 441
S P +K++ S+ D + A+ P+P +SS+E++DW+PP
Sbjct: 223 SHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPP 282
Query: 442 DKKVDTRKYRAEPKSIYEYQ-------------------------PGKSSVLTNE--KMS 474
D+KVDTRK+R+EP+SI+EY+ PG+ + ++ +++
Sbjct: 283 DRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTPTPVPREPGRKPLSSSRLGEVT 342
Query: 475 SAISPTPEISSETPGYIYSSNFHAV------KRESDGAPGDLTSLENERQIYKSVLEG-- 526
+ SP P + TP SS A+ K+ D + + NE +Y+S ++
Sbjct: 343 GSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQDHSSGVFNEASLYQSSIDRSL 398
Query: 527 ---------------------------------------GDIPLQGLSGL-------KRP 540
G + L G S P
Sbjct: 399 ERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSP 458
Query: 541 SSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQK 598
SS + KD ESPR + D S RR +KE PA+A +DFKAQT KEL +K
Sbjct: 459 SSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKK 517
Query: 599 GDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAK 657
GD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK
Sbjct: 518 GDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAK 577
Query: 658 FNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPV 717
+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K
Sbjct: 578 YNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAE 636
Query: 718 DYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELR 777
DY D P S S S + Q+ T + Q + F QALY+Y P+N+DELELR
Sbjct: 637 DYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELR 694
Query: 778 DGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 695 ESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 731
>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
sapiens]
Length = 824
Score = 375 bits (962), Expect = e-103
Identities = 240/598 (40%), Positives = 330/598 (55%), Gaps = 117/598 (19%)
Query: 326 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 379
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 235 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 294
Query: 380 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 429
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 295 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 354
Query: 430 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQ------------------- 461
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+
Sbjct: 355 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPPPLPTTP 414
Query: 462 ------PGKSSVLTNE--KMSSAISPTPEISSETPGYIYSSNFHAV------KRESDGAP 507
PG+ + ++ +++ + SP P + TP SS A+ K+ D
Sbjct: 415 TPVPREPGRKPLSSSRLGEVTGSPSPPPRSGAPTP----SSRAPALSPTRPPKKPLDYVQ 470
Query: 508 GDLTSLENERQIYKSVLEG----------------------------------------- 526
+ + NE +Y+S ++
Sbjct: 471 DHSSGVFNEASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSP 530
Query: 527 GDIPLQGLSGL-------KRPSSSASTKDSESPRHFIPA--DYLESTEEFIRRRHDDKEM 577
G + L G S PSS + KD ESPR + D S RR +KE
Sbjct: 531 GRVDLPGSSTTLTKSFTSSSPSSPSRAKDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEK 589
Query: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 637
PA+A +DFKAQT KEL +KGD VYI ++IDQNWYEGEHHGRVGIFP +Y+E L P EK
Sbjct: 590 LPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEK 649
Query: 638 AQPKKLTP-VQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSR 696
AQP + P Q E GEAIAK+NFN DT VE+S RKG+R+ LL++VD+NWYEG+IPGT+R
Sbjct: 650 AQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNR 709
Query: 697 QGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQD 756
QGIFP++YV+V+K+ K DY D P S S S + Q+ T + Q +
Sbjct: 710 QGIFPVSYVEVVKKN-TKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGE 768
Query: 757 LFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
F QALY+Y P+N+DELELR+ D++DVMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 769 PF--QALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 824
>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
sapiens]
Length = 1004
Score = 297 bits (760), Expect = 3e-80
Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)
Query: 547 KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 604
+D ESPR + D S RR +KE PA+A +DFKAQT KEL +KGD VYI
Sbjct: 738 QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 796
Query: 605 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 663
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 797 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 856
Query: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 723
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 857 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 915
Query: 724 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 783
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 916 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 973
Query: 784 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 974 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1004
Score = 113 bits (283), Expect = 6e-25
Identities = 78/210 (37%), Positives = 115/210 (54%), Gaps = 17/210 (8%)
Query: 352 PLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSE------DTKSPLSVPRS-KSE 404
PL+ +R KDWYKTMFKQIH +++ LY+P YS T PLS S S
Sbjct: 6 PLQTVDRPKDWYKTMFKQIHMVHKPG---LYNPPYSAQSHPAAKTQTYRPLSKSHSDNSP 62
Query: 405 MSYIDGEKVVKRS-ATLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPG 463
++ D V P+P +SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PG
Sbjct: 63 NAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPG 122
Query: 464 KSSVLTNEKMSSAISPTPEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYK 521
KSS+L +E+ +S + + S E P +S+F +R+S+ A G L ++
Sbjct: 123 KSSILQHERPASLYQSSIDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---A 178
Query: 522 SVLEGGDIPLQGLSGLKRPSSSASTKDSES 551
S G + L G S S ++S+ S S
Sbjct: 179 SRTSPGRVDLPGSSTTLTKSFTSSSPSSPS 208
>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
sapiens]
Length = 1100
Score = 297 bits (760), Expect = 3e-80
Identities = 156/271 (57%), Positives = 191/271 (70%), Gaps = 7/271 (2%)
Query: 547 KDSESPRHFIPA--DYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYI 604
+D ESPR + D S RR +KE PA+A +DFKAQT KEL +KGD VYI
Sbjct: 834 QDRESPRSYSSTLTDMGRSAPRE-RRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYI 892
Query: 605 YKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTP-VQVLEYGEAIAKFNFNGD 663
++IDQNWYEGEHHGRVGIFP +Y+E L P EKAQP + P Q E GEAIAK+NFN D
Sbjct: 893 LRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNAD 952
Query: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLP 723
T VE+S RKG+R+ LL++VD+NWYEG+IPGT+RQGIFP++YV+V+K+ K DY D P
Sbjct: 953 TNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKN-TKGAEDYPDPP 1011
Query: 724 FSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVD 783
S S S + Q+ T + Q + F QALY+Y P+N+DELELR+ D++D
Sbjct: 1012 IPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPF--QALYNYTPRNEDELELRESDVID 1069
Query: 784 VMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
VMEKCDDGWFVGTSRRTK FGTFPGNYVK L
Sbjct: 1070 VMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL 1100
Score = 121 bits (303), Expect = 3e-27
Identities = 87/253 (34%), Positives = 141/253 (55%), Gaps = 31/253 (12%)
Query: 326 RAKDDSRRV--VKSTQDLSDVSMDEVGIP--LRNT-ERSKDWYKTMFKQIHKLNR-DDDS 379
R+ ++ +RV +K+ +DE GIP +R T +R KDWYKTMFKQIH +++ DDD+
Sbjct: 56 RSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDT 115
Query: 380 DLYSPRYSFSEDTKSP----LSVPRSKSEM------SYIDGEKVVKRSATLPLPARSSSL 429
D+Y+ Y+++ +P S P +K++ S+ D + A+ P+P
Sbjct: 116 DMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPP 175
Query: 430 ---------KSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPT 480
+SS+E++DW+PPD+KVDTRK+R+EP+SI+EY+PGKSS+L +E+ +S +
Sbjct: 176 PVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSS 235
Query: 481 PEISSETP--GYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLK 538
+ S E P +S+F +R+S+ A G L ++ S G + L G S
Sbjct: 236 IDRSLERPMSSASMASDFRK-RRKSEPAVGPPRGLGDQS---ASRTSPGRVDLPGSSTTL 291
Query: 539 RPSSSASTKDSES 551
S ++S+ S S
Sbjct: 292 TKSFTSSSPSSPS 304
>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
sapiens]
Length = 671
Score = 284 bits (727), Expect = 2e-76
Identities = 201/570 (35%), Positives = 283/570 (49%), Gaps = 90/570 (15%)
Query: 328 KDDSRRVVKSTQDLSDVSMDEVGIPLR---NTERSKDWYKTMFKQIHKLNRDDDSDLY-- 382
KD RR + + +DE G+P+ + +R +DWY+ MF+QIH+ D D
Sbjct: 109 KDSKRRDKRWVKYEGIGPVDESGMPIAPRSSVDRPRDWYRRMFQQIHRKMPDLQLDWTFE 168
Query: 383 ----SPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSER--- 435
PR+ ++ + P + S D + + RS P S++ S +
Sbjct: 169 EPPRDPRHLGAQQRPAHRPGPATSSSGRSWDHSEELPRSTFNYRPGAFSTVLQPSNQVLR 228
Query: 436 ------NDW--EPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSET 487
N W E ++ + + PK PG+ E + E+S+E
Sbjct: 229 RREKVDNVWTEESWNQFLQELETGQRPKKPLVDDPGEKPSQPIEVLLER--ELAELSAEL 286
Query: 488 PGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTK 547
+ + +S AP + E + P G R S
Sbjct: 287 DKDLRAIETRLPSPKSSPAPR--RAPEQRPPAGPASAWSSSYPHAPYLGSARSLSPHKMA 344
Query: 548 DSESP----RHFIPADYLESTEEFIRR-------RHDDKEMRPARAKFDFKAQTLKELPL 596
D SP R F+ Y ST + R ++K+ + AR KFDF+AQ+ KEL L
Sbjct: 345 DGGSPFLGRRDFV---YPSSTRDPSASNGGGSPARREEKKRKAARLKFDFQAQSPKELTL 401
Query: 597 QKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIA 656
QKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E+LP E +P K QVLEYGEA+A
Sbjct: 402 QKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVEVLPADEIPKPIKPPTYQVLEYGEAVA 461
Query: 657 KFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP----- 711
++ F GD +VE+SFRKGE I L+R+V+ENWYEGRI GT RQGIFP +YV V + P
Sbjct: 462 QYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVSREPRLRLC 521
Query: 712 --------------------------LVKNPVDYMDLPFSSSPSRSATASP-QQPQAQQR 744
+++P D +DL +SP R+ + P Q+P+ Q +
Sbjct: 522 DDGPQLPTSPRLTAAARSARHPSSPSALRSPADPIDLGGQTSPRRTGFSFPTQEPRPQTQ 581
Query: 745 RV-TP------------------DRSQTSQDLFS-YQALYSYIPQNDDELELRDGDIVDV 784
+ TP TSQ ++ Y+A+Y Y PQN+DELELR+GD VDV
Sbjct: 582 NLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWTPYRAMYQYRPQNEDELELREGDRVDV 641
Query: 785 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
M++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 642 MQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671
>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
sapiens]
Length = 329
Score = 275 bits (703), Expect = 1e-73
Identities = 145/296 (48%), Positives = 191/296 (64%), Gaps = 52/296 (17%)
Query: 571 RHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIE 630
R ++K+ + AR KFDF+AQ+ KEL LQKGDIVYI+K++D+NW EGEHHGR+GIFP Y+E
Sbjct: 34 RREEKKRKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEHHGRLGIFPANYVE 93
Query: 631 LLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 690
+LP E +P K QVLEYGEA+A++ F GD +VE+SFRKGE I L+R+V+ENWYEGR
Sbjct: 94 VLPADEIPKPIKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGR 153
Query: 691 IPGTSRQGIFPITYVDVIKRP-------------------------------LVKNPVDY 719
I GT RQGIFP +YV V + P +++P D
Sbjct: 154 ITGTGRQGIFPASYVQVSREPRLRLCDDGPQLPTSPRLTAAARSARHPSSPSALRSPADP 213
Query: 720 MDLPFSSSPSRSATASP-QQPQAQQRRV-TP------------------DRSQTSQDLFS 759
+DL +SP R+ + P Q+P+ Q + + TP TSQ ++
Sbjct: 214 IDLGGQTSPRRTGFSFPTQEPRPQTQNLGTPGPALSHSRGPSHPLDLGTSSPNTSQIHWT 273
Query: 760 -YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
Y+A+Y Y PQN+DELELR+GD VDVM++CDDGWFVG SRRT++FGTFPGNYV P+
Sbjct: 274 PYRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 115 bits (288), Expect = 2e-25
Identities = 159/746 (21%), Positives = 280/746 (37%), Gaps = 130/746 (17%)
Query: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
S+ +P V P + GT G P P + + P+T P L
Sbjct: 49 SSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPN 108
Query: 181 PHLQRWPHHSQPARA-------SGSFAPISQTPP-----SFSPPPPLVPPAPEDLRRVSE 228
P L R + P R SG P P S S P P AP L+ V+
Sbjct: 109 PGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAP--LKPVTV 166
Query: 229 PDLTGAVSSTDSSPLLNE----------------VSSSLIGTDSQAFPSVSKPSSAYPST 272
P S + L E V LI D P+ PS
Sbjct: 167 PPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPT---PSGNLAEE 223
Query: 273 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRA 327
++ + ++ +L + ++P+ ER V APT++ P PGK + +
Sbjct: 224 SVGSEMVL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDP 273
Query: 328 KDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS 387
+ + P+ NT + T+ ++ + R + + P +
Sbjct: 274 QSPPPLPAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQT 313
Query: 388 FSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDT 447
P PR + + + K P P + S+ + S+++ + +D
Sbjct: 314 GGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDL 373
Query: 448 RKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNF-----HAVKRE 502
+K ++ + KS V N+ + P P+ PG+ S + H + E
Sbjct: 374 QKKQSNLAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMLSVPHGIANE 424
Query: 503 S--DGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPR-HFIPAD 559
PG+L+ + + E + Q K ++ R H
Sbjct: 425 DIVSQNPGELSCKRGDVLVMLKQTENNYLECQ--------------KGEDTGRVHLSQMK 470
Query: 560 YLESTEEFIRRRHDDKE--MRP-------ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQ 610
+ +E +R R +D +P A DF A+ + +L L G+IVY+ ++ID
Sbjct: 471 IITPLDEHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDT 530
Query: 611 NWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 668
+WY G ++GIFP Y++++ P ++ ++ +A+F + G+ + E+
Sbjct: 531 DWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDEL 590
Query: 669 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 728
SF +GE I L V+E W G + G R GIFP+ +V+ ++ D P S
Sbjct: 591 SFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPVE-----------DYPTSG-- 635
Query: 729 SRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK 787
+ S + P ++ + SQ + + +AL+S+ + D+L + GD + ++E+
Sbjct: 636 --ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILER 693
Query: 788 CDDGWFVGTSRRTKQFGTFPGNYVKP 813
D W G R + G FP +V+P
Sbjct: 694 LDSDWCRG--RLQDREGIFPAVFVRP 717
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPP------- 634
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 637
Query: 635 ---------AEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 685
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 638 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 697
Query: 686 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 745
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 698 WCRGRLQ--DREGIFPAVFV----RPC---------------PAEAKSMLAIVPKGRKAK 736
Query: 746 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 805
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 737 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 778
Query: 806 FPGNYVKPLYL 816
FP NY++ L +
Sbjct: 779 FPKNYIQFLQI 789
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 632
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 733 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 112 bits (281), Expect = 1e-24
Identities = 158/732 (21%), Positives = 271/732 (37%), Gaps = 125/732 (17%)
Query: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
S+ +P V P + GT G P P + + P+T P L
Sbjct: 49 SSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPN 108
Query: 181 PHLQRWPHHSQPARA-------SGSFAPISQTPP-----SFSPPPPLVPPAPEDLRRVSE 228
P L R + P R SG P P S S P P AP L+ V+
Sbjct: 109 PGLIRSVNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSENPTYPSAP--LKPVTV 166
Query: 229 PDLTGAVSSTDSSPLLNE----------------VSSSLIGTDSQAFPSVSKPSSAYPST 272
P S + L E V LI D P+ PS
Sbjct: 167 PPRLAGASQAKAYKSLGEGPPANPPVPVLQSKPLVDIDLISFDDDVLPT---PSGNLAEE 223
Query: 273 TIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEK-----PTSPGKAIEKRA 327
++ + ++ +L + ++P+ ER V APT++ P PGK + +
Sbjct: 224 SVGSEMVL-------DPFQLPAKTEPIKERAV---QPAPTRKPTVIRIPAKPGKCLHEDP 273
Query: 328 KDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS 387
+ + P+ NT + T+ ++ + R + + P +
Sbjct: 274 QSPPPLPAEK--------------PIGNT------FSTVSGKLSNVERTRNLESNHPGQT 313
Query: 388 FSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDT 447
P PR + + + K P P + S+ + S+++ + +D
Sbjct: 314 GGFVRVPPRLPPRPVNGKTIPTQQPPTKVPPERPPPPKLSATRRSNKKLPFNRSSSDMDL 373
Query: 448 RKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHAVKRESDGAP 507
+K ++ + KS V N+ + P P+ PG+ S +
Sbjct: 374 QKKQSNLAT--GLSKAKSQVFKNQ--DPVLPPRPK-----PGHPLYSKYMR--------- 415
Query: 508 GD-LTSLENERQIYKSVLEGGDIPLQGLSGLK--RPSSSASTKDSESPRHFIPADYLEST 564
GD L L+ Y +G D LS +K P P H
Sbjct: 416 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSH---------- 465
Query: 565 EEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIF 624
++ D A DF A+ + +L L G+IVY+ ++ID +WY G ++GIF
Sbjct: 466 ----AQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIF 521
Query: 625 PRTYIELL--PPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQV 682
P Y++++ P ++ ++ +A+F + G+ + E+SF +GE I L V
Sbjct: 522 PANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYV 581
Query: 683 DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQ 742
+E W G + G R GIFP+ +V+ ++ D P S + S + P
Sbjct: 582 NEEWARGEVRG--RTGIFPLNFVEPVE-----------DYPTSG----ANVLSTKVPLKT 624
Query: 743 QRRVTPDRSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTK 801
++ + SQ + + +AL+S+ + D+L + GD + ++E+ D W G R
Sbjct: 625 KKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRG--RLQD 682
Query: 802 QFGTFPGNYVKP 813
+ G FP +V+P
Sbjct: 683 REGIFPAVFVRP 694
Score = 92.4 bits (228), Expect = 1e-18
Identities = 176/823 (21%), Positives = 301/823 (36%), Gaps = 150/823 (18%)
Query: 50 TPSSSPASPQETRQHESKPGLEPEPSS---ADEW------RLSSSADANGNAQPSSLAAK 100
TP S P P + KP + P+P++ + EW RL ++ P A
Sbjct: 38 TPRSLPPKPTVS---SGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAG 94
Query: 101 GYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCV--- 157
P LP + S PE+ ++D G++ P PL V
Sbjct: 95 SIPVTKPELPKKPNPGLIRS--VNPEIPGRGPLAESSDSGKKVPTPAPRPLLLKKSVSSE 152
Query: 158 -PTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLV 216
PT P+ + P+T +PP L A + ++ + + PP+ P P L
Sbjct: 153 NPTYPS--APLKPVT-------VPPRLAG-------ASQAKAYKSLGEGPPANPPVPVLQ 196
Query: 217 PPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKP---SSAYPSTT 273
D+ +S D V T S L E S + D P+ ++P + P+ T
Sbjct: 197 SKPLVDIDLISFDD---DVLPTPSGNLAEESVGSEMVLDPFQLPAKTEPIKERAVQPAPT 253
Query: 274 IVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRR 333
PT++ + P + +D P P K I S +
Sbjct: 254 R-KPTVIRI---------------PAKPGKCLHED--PQSPPPLPAEKPIGNTFSTVSGK 295
Query: 334 V--VKSTQDLSDVSMDEVG----IPLRNTERSKDWYKTMFKQIHKLNRDDDSDLYSPRYS 387
+ V+ T++L + G +P R R + KT+ Q + P+ S
Sbjct: 296 LSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNG-KTIPTQQPPTKVPPERPP-PPKLS 353
Query: 388 FSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSERNDWEPPDKKVDT 447
+ + L RS S+M D +K AT A+S K+ P
Sbjct: 354 ATRRSNKKLPFNRSSSDM---DLQKKQSNLATGLSKAKSQVFKNQDPVLPPRPKPGHPLY 410
Query: 448 RKY---------RAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSSNFHA 498
KY + + E Q G+ + + I+P E P + HA
Sbjct: 411 SKYMRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRP----NDPSHA 466
Query: 499 VKRESDGAPGDLTSLE-NERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIP 557
K GAP + + Q+ L G+I L++ + + + P
Sbjct: 467 QKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYL----LEKIDTDWYRGNCRNQIGIFP 522
Query: 558 ADYLESTEEFIRRRHDDKEMRPAR--------AKFDFKAQTLKELPLQKGDIVYIYKQID 609
A+Y++ + + +E + A+F++ + EL +G+I+ + + ++
Sbjct: 523 ANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVN 582
Query: 610 QNWYEGEHHGRVGIFPRTYIELLP----------------PAEKAQPKKLTPVQVLEYGE 653
+ W GE GR GIFP ++E + +K + V L
Sbjct: 583 EEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEW 642
Query: 654 AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
A +F +T ++SF++G+RI +L ++D +W GR+ R+GIFP +V RP
Sbjct: 643 CEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRL--QDREGIFPAVFV----RP-- 694
Query: 714 KNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDE 773
P+ + + P+ ++ + ALY + +N+DE
Sbjct: 695 -------------CPAEAKSMLAIVPKGRKAK----------------ALYDFRGENEDE 725
Query: 774 LELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLYL 816
L + GDI+ +E DD W G + G FP NY++ L +
Sbjct: 726 LSFKAGDIITELESVDDDWMSG--ELMGKSGIFPKNYIQFLQI 766
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 107 bits (267), Expect = 4e-23
Identities = 154/701 (21%), Positives = 268/701 (38%), Gaps = 99/701 (14%)
Query: 121 SAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIP 180
S+ +P V P + GT G P P + + P+T P L
Sbjct: 49 SSGKPSVAPKPAANRASGEWDSGTENRLKVTSKEGLTPYPPLQEAGSIPVTKPELPKKPN 108
Query: 181 PHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDS 240
P L R + P R P++++ S P PAP L + + ++ + S
Sbjct: 109 PGLIRSVNPEIPGRG-----PLAESSDSGKKVPT---PAPRPL--LLKKSVSSENPTYPS 158
Query: 241 SPLLN-EVSSSLIG-TDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDP 298
+PL V L G + ++A+ S+ + A NP + +LQ L S D
Sbjct: 159 APLKPVTVPPRLAGASQAKAYKSLGEGPPA-------NPPVPVLQSKPLVDIDLISFDDD 211
Query: 299 VSERRVGEQDSAPTQEKPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTER 358
V PT G E+ S V+ +D P+ NT
Sbjct: 212 VL---------------PTPSGNLAEESV--GSEMVLGLHEDPQSPPPLPAEKPIGNT-- 252
Query: 359 SKDWYKTMFKQIHKLNRDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSA 418
+ T+ ++ + R + + P + P PR + + + K
Sbjct: 253 ----FSTVSGKLSNVERTRNLESNHPGQTGGFVRVPPRLPPRPVNGKTIPTQQPPTKVPP 308
Query: 419 TLPLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAIS 478
P P + S+ + S+++ + +D +K ++ + KS V N+ +
Sbjct: 309 ERPPPPKLSATRRSNKKLPFNRSSSDMDLQKKQSNLAT--GLSKAKSQVFKNQ--DPVLP 364
Query: 479 PTPEISSETPGYIYSSNFHAVKRESDGAPGD-LTSLENERQIYKSVLEGGDIPLQGLSGL 537
P P+ PG+ S + GD L L+ Y +G D LS +
Sbjct: 365 PRPK-----PGHPLYSKYMR---------GDVLVMLKQTENNYLECQKGEDTGRVHLSQM 410
Query: 538 K--RPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELP 595
K P P H ++ D A DF A+ + +L
Sbjct: 411 KIITPLDEHLRSRPNDPSH--------------AQKPVDSGAPHAVVLHDFPAEQVDDLN 456
Query: 596 LQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL--PPAEKAQPKKLTPVQVLEYGE 653
L G+IVY+ ++ID +WY G ++GIFP Y++++ P ++ ++
Sbjct: 457 LTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSR 516
Query: 654 AIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
+A+F + G+ + E+SF +GE I L V+E W G + G R GIFP+ +V+ ++
Sbjct: 517 CVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG--RTGIFPLNFVEPVE---- 570
Query: 714 KNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY-QALYSYIPQNDD 772
D P S + S + P ++ + SQ + + +AL+S+ + D
Sbjct: 571 -------DYPTSG----ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSD 619
Query: 773 ELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKP 813
+L + GD + ++E+ D W G R + G FP +V+P
Sbjct: 620 DLSFKRGDRIQILERLDSDWCRG--RLQDREGIFPAVFVRP 658
Score = 90.9 bits (224), Expect = 4e-18
Identities = 63/251 (25%), Positives = 111/251 (44%), Gaps = 55/251 (21%)
Query: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLP-------- 633
A+F++ + EL +G+I+ + + +++ W GE GR GIFP ++E +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGAN 578
Query: 634 --------PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDEN 685
+K + V L A +F +T ++SF++G+RI +L ++D +
Sbjct: 579 VLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSD 638
Query: 686 WYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 745
W GR+ R+GIFP +V RP P+ + + P+ ++ +
Sbjct: 639 WCRGRL--QDREGIFPAVFV----RP---------------CPAEAKSMLAIVPKGRKAK 677
Query: 746 VTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGT 805
ALY + +N+DEL + GDI+ +E DD W G + G
Sbjct: 678 ----------------ALYDFRGENEDELSFKAGDIITELESVDDDWMSG--ELMGKSGI 719
Query: 806 FPGNYVKPLYL 816
FP NY++ L +
Sbjct: 720 FPKNYIQFLQI 730
Score = 64.7 bits (156), Expect = 3e-10
Identities = 58/223 (26%), Positives = 99/223 (44%), Gaps = 38/223 (17%)
Query: 598 KGDIVYIYKQIDQNWYE---GEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQV-LEYG- 652
+GD++ + KQ + N+ E GE GRV + I L +++P + Q ++ G
Sbjct: 379 RGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGA 438
Query: 653 -EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 711
A+ +F + +++ GE + LL ++D +WY G ++ GIFP YV VI
Sbjct: 439 PHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNC--RNQIGIFPANYVKVI--- 493
Query: 712 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 771
+D+P + R +S V R A + YI +
Sbjct: 494 --------IDIPEGGNGKRECVSS--------HCVKGSRC---------VARFEYIGEQK 528
Query: 772 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
DEL +G+I+ + E ++ W G R + G FP N+V+P+
Sbjct: 529 DELSFSEGEIIILKEYVNEEWARGEVR--GRTGIFPLNFVEPV 569
Score = 52.0 bits (123), Expect = 2e-06
Identities = 22/55 (40%), Positives = 34/55 (61%)
Query: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL 632
R A+A +DF+ + EL + GDI+ + +D +W GE G+ GIFP+ YI+ L
Sbjct: 674 RKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 94.7 bits (234), Expect = 3e-19
Identities = 56/164 (34%), Positives = 91/164 (55%), Gaps = 13/164 (7%)
Query: 653 EAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL 712
EAI +F++ E++ GE IT +R+ D W+EG+I G R+G+FP +V IK+ +
Sbjct: 3 EAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQING--RRGLFPDNFVREIKKEM 60
Query: 713 VKNPVDYM--DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 770
K+P+ + P PS ++ S + +R R + Q +SY+PQN
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRC-------QVAFSYLPQN 113
Query: 771 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
DDELEL+ GDI++V+ + ++GW+ G + G FP N++K L
Sbjct: 114 DDELELKVGDIIEVVGEVEEGWWEGV--LNGKTGMFPSNFIKEL 155
Score = 77.8 bits (190), Expect = 4e-14
Identities = 72/281 (25%), Positives = 129/281 (45%), Gaps = 31/281 (11%)
Query: 545 STKDSESPRHFIPA-DYLESTEEFIR-RRHDDKEMRPARAKFDFKAQTLKELPLQKGDIV 602
+ K E P H +P+ + L S+E +R + ++ R + F + Q EL L+ GDI+
Sbjct: 66 TNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDII 125
Query: 603 YIYKQIDQNWYEGEHHGRVGIFPRTYI-ELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFN 661
+ ++++ W+EG +G+ G+FP +I EL +++ + + E +
Sbjct: 126 EVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDG 185
Query: 662 GDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPL-VKNPVDYM 720
GD+ S +G T+ + ++ G IF + + R + V+N D++
Sbjct: 186 GDSSSTKS--EGANGTVATAAIQ---PKKVKGVGFGDIFKDKPIKLRPRSIEVEN--DFL 238
Query: 721 DLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFS-----YQALYSYIPQNDDELE 775
+ + AT + TPD S+T D + + ++ Y QNDDEL
Sbjct: 239 PVEKTIGKKLPATTA-----------TPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELT 287
Query: 776 LRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTFPGNYVKPL 814
+++GDIV ++ K D GW+ G + G FP N+VK L
Sbjct: 288 IKEGDIVTLINKDCIDVGWWEGELNGRR--GVFPDNFVKLL 326
Score = 58.5 bits (140), Expect = 2e-08
Identities = 42/154 (27%), Positives = 72/154 (46%), Gaps = 27/154 (17%)
Query: 577 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELL---- 632
M A +FD++AQ EL + G+I+ ++ D W+EG+ +GR G+FP ++ +
Sbjct: 1 MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEM 60
Query: 633 ---PPAEKAQPKKLTPV---QVLEYGEAIAKFNFNGD---------------TQVEMSFR 671
P KA K L V L E I + N G+ E+ +
Sbjct: 61 KKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELK 120
Query: 672 KGERITLLRQVDENWYEGRIPGTSRQGIFPITYV 705
G+ I ++ +V+E W+EG + G + G+FP ++
Sbjct: 121 VGDIIEVVGEVEEGWWEGVLNG--KTGMFPSNFI 152
Score = 57.0 bits (136), Expect = 7e-08
Identities = 40/127 (31%), Positives = 65/127 (51%), Gaps = 22/127 (17%)
Query: 524 LEGGDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDDKEMRPARAK 583
+E +P++ G K P+++A+ S+ TE R + D +
Sbjct: 233 VENDFLPVEKTIGKKLPATTATPDSSK-------------TEMDSRTKSKDY----CKVI 275
Query: 584 FDFKAQTLKELPLQKGDIVYIYKQ--IDQNWYEGEHHGRVGIFPRTYIELLPP---AEKA 638
F ++AQ EL +++GDIV + + ID W+EGE +GR G+FP +++LLPP E
Sbjct: 276 FPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGN 335
Query: 639 QPKKLTP 645
+PKK P
Sbjct: 336 RPKKPPP 342
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 92.4 bits (228), Expect = 1e-18
Identities = 67/246 (27%), Positives = 113/246 (45%), Gaps = 33/246 (13%)
Query: 586 FKAQTLKELPLQKGDIVYIYKQID-QNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLT 644
++AQ EL L GD+V + + + W GE GR G+FP ++ +P + +
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQEIPETLRGSGEARR 68
Query: 645 PVQVLEYGEAI----------AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGT 694
P G F+++ + E+ + GE + +++++++ W+ G+ G
Sbjct: 69 PRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG- 127
Query: 695 SRQGIFPITYVDVIKR--PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRV---TPD 749
+ G FP +V+++ P + NP D+P S + PQ+P PD
Sbjct: 128 -QLGAFPSNFVELLDSGPPSLGNP----DMP-------SVSPGPQRPPKLSSLAYDSPPD 175
Query: 750 RSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKC--DDGWFVGTSRRTKQFGTFP 807
QT Y+ L+ Y P+ DEL LR GD+V V+ K D GW+ G + + G FP
Sbjct: 176 YLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRR--GVFP 233
Query: 808 GNYVKP 813
N+V P
Sbjct: 234 DNFVLP 239
Score = 72.4 bits (176), Expect = 2e-12
Identities = 58/222 (26%), Positives = 103/222 (46%), Gaps = 39/222 (17%)
Query: 569 RRRHDDKEMRPAR---AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFP 625
RR H K RP R F + + EL LQ G+IV + K+I+ W+ G+ +G++G FP
Sbjct: 74 RRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFP 133
Query: 626 RTYIELL---PPA-----------EKAQPKKLTP---------VQVLEYGEAI-AKFNFN 661
++ELL PP+ +P KL+ +Q + + E F++
Sbjct: 134 SNFVELLDSGPPSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQ 193
Query: 662 GDTQVEMSFRKGERITLLRQV--DENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDY 719
+ E++ R+G+ + +L + D+ W+EG G R+G+FP + V+ P +K V
Sbjct: 194 PEAPDELALRRGDVVKVLSKTTEDKGWWEGECQG--RRGVFPDNF--VLPPPPIKKLVPR 249
Query: 720 MDLPFSSSPSRS------ATASPQQPQAQQRRVTPDRSQTSQ 755
+ S+P + T+ P + P +++TS+
Sbjct: 250 KVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSR 291
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/163 (25%), Positives = 73/163 (44%), Gaps = 25/163 (15%)
Query: 653 EAIAKFNFNGDTQVEMSFRKGERITLLRQVD-ENWYEGRIPGTSRQGIFPITYVDVIKRP 711
E + + + E+S G+ + +R V W G G R G+FP V I
Sbjct: 2 EVLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGG--RYGLFPERLVQEIPET 59
Query: 712 LVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQND 771
L + ++P+ +RR P + Q +SY P+
Sbjct: 60 L------------------RGSGEARRPRCARRRGHPAKHPRPQRWCKVN--FSYSPEQA 99
Query: 772 DELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
DEL+L+ G+IV+++++ +DGW++G ++ Q G FP N+V+ L
Sbjct: 100 DELKLQAGEIVEMIKEIEDGWWLG--KKNGQLGAFPSNFVELL 140
>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
Length = 882
Score = 83.6 bits (205), Expect = 7e-16
Identities = 55/181 (30%), Positives = 90/181 (49%), Gaps = 18/181 (9%)
Query: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640
+A + ++ + +L KGDI+ + +++D+ WY GE HG G P +YI+ + P A P
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQGFLPASYIQCIQPLPHAPP 259
Query: 641 KKLTPVQVLEYGEAIAKFNFNGDTQVE--MSFRKGERITLLRQVDENWYEGRIPGTSRQG 698
+ G+A+ F Q + ++F K E +T+LR+VDENW EG + + G
Sbjct: 260 Q----------GKALYDFEMKDKDQDKDCLTFTKDEILTVLRRVDENWAEGML--GDKIG 307
Query: 699 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 758
IFP+ YV++ K ++ MD P ++ S S AS V P + +S
Sbjct: 308 IFPLLYVEL--NDSAKQLIE-MDKPCPAAAS-SCNASLPSDSGAVASVAPSPTLSSSGAV 363
Query: 759 S 759
S
Sbjct: 364 S 364
Score = 81.3 bits (199), Expect = 3e-15
Identities = 42/90 (46%), Positives = 53/90 (58%), Gaps = 2/90 (2%)
Query: 725 SSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDV 784
SSS + TA P+ + TP + Q ++ Y ALY+Y PQ DELEL G++ V
Sbjct: 436 SSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV--YLALYAYKPQKSDELELHKGEMYRV 493
Query: 785 MEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
+EKC DGWF G S RT G FPGNYV P+
Sbjct: 494 LEKCQDGWFKGASLRTGVSGVFPGNYVTPV 523
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/93 (37%), Positives = 57/93 (61%), Gaps = 10/93 (10%)
Query: 720 MDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDG 779
+DL F+S PSR A S + + + + +R Y+ + SY PQ++ E+EL++G
Sbjct: 798 LDLNFTS-PSRQAPLSMAAIRPEPKLLPRER---------YRVVVSYPPQSEAEIELKEG 847
Query: 780 DIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
DIV V +K +DGW+ GT +R + G FPG++V+
Sbjct: 848 DIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 45.8 bits (107), Expect = 2e-04
Identities = 18/52 (34%), Positives = 35/52 (67%), Gaps = 2/52 (3%)
Query: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHGRVGIFPRTYIE 630
R + Q+ E+ L++GDIV+++K+ + WY+G + +GR G+FP +++E
Sbjct: 829 RVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 37.0 bits (84), Expect = 0.074
Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 1/80 (1%)
Query: 632 LPPAEKAQPKKLTPVQV-LEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGR 690
+P A ++ TP +V L +A + + E+ KGE +L + + W++G
Sbjct: 446 VPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGA 505
Query: 691 IPGTSRQGIFPITYVDVIKR 710
T G+FP YV + R
Sbjct: 506 SLRTGVSGVFPGNYVTPVSR 525
Score = 35.8 bits (81), Expect = 0.16
Identities = 17/52 (32%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
+ALYSY + +L+ GDI+ + K D+ W+ G T+ G P +Y++
Sbjct: 200 KALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGELHGTQ--GFLPASYIQ 249
Score = 33.1 bits (74), Expect = 1.1
Identities = 10/43 (23%), Positives = 28/43 (65%)
Query: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVD 706
++ E+ ++G+ + + ++ ++ WY+G + R G+FP ++V+
Sbjct: 838 SEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVE 880
Score = 32.7 bits (73), Expect = 1.4
Identities = 15/50 (30%), Positives = 26/50 (52%), Gaps = 2/50 (4%)
Query: 582 AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 629
A + +K Q EL L KG++ + ++ W++G G G+FP Y+
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYV 520
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 83.2 bits (204), Expect = 9e-16
Identities = 76/288 (26%), Positives = 118/288 (40%), Gaps = 55/288 (19%)
Query: 534 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEMRPARAKFDFKA 588
+SG R S+S + SESP A + S EEFI A + +++
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFI-------------AMYTYES 1015
Query: 589 QTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPV-Q 647
+L Q+GD++ + K+ D +W+ G + G+FP Y+ L K + +
Sbjct: 1016 SEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGK 1074
Query: 648 VLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFPITY 704
E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ G FP Y
Sbjct: 1075 KPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 705 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALY 764
V ++ SP S + P +S + +Y
Sbjct: 1133 VKLL------------------SPGTSKITPTEPP----------KSTALAAVCQVIGMY 1164
Query: 765 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 54/279 (19%)
Query: 555 FIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE 614
F PA S+ + + + E A+A + ++A+ L K D++ + +Q D W+
Sbjct: 893 FTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF- 951
Query: 615 GEHHGRVGIFPRTYIELLP-PAEKA---------QPKKLTPV------QVLEYGEAIAKF 658
GE G+ G FP++Y++L+ P K+ P L V V+ E IA +
Sbjct: 952 GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMY 1011
Query: 659 NFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVD 718
+ Q +++F++G+ + L+ + D +W+ G + + G+FP YV +
Sbjct: 1012 TYESSEQGDLTFQQGD-VILVTKKDGDWWTGTV--GDKAGVFPSNYVRL----------- 1057
Query: 719 YMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRD 778
S TA ++ + Q + SY ++L L
Sbjct: 1058 -------KDSEGSGTAGKTGSLGKKPEIA-------------QVIASYTATGPEQLTLAP 1097
Query: 779 GDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 814
G ++ + +K GW+ G + + +Q G FP NYVK L
Sbjct: 1098 GQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 30/242 (12%)
Query: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLP 633
RA + F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 634 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRI 691
E P K V + A A +T ++ E T NW +
Sbjct: 806 ENEVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTW 857
Query: 692 PGTSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDR 750
P ++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 858 PTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV---- 913
Query: 751 SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 810
+ QALY + + D+ L D++ V+E+ D WF Q G FP +Y
Sbjct: 914 -----EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSY 965
Query: 811 VK 812
VK
Sbjct: 966 VK 967
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 584 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 639
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 41.6 bits (96), Expect = 0.003
Identities = 118/633 (18%), Positives = 225/633 (35%), Gaps = 145/633 (22%)
Query: 208 SFSPPPPLVPPA--PEDLRRVSEPDLTGAVSSTD------SSPLLNEVSSSLIGTDSQAF 259
S P PP++PP P RRV +SST P+L + L F
Sbjct: 291 SGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTF 350
Query: 260 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----E 314
+ + + + LL+ R++Q+RL+ L ER+ E+ + E
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
Query: 315 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 374
K + +E++ +++ R+ ++ E +R +W
Sbjct: 411 KQLEKQRELERQREEERRK---------EIERREAAKRELERQRQLEW-----------E 450
Query: 375 RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE 434
R+ +L + R ED + V ++K + + E + + L + + +++
Sbjct: 451 RNRRQELLNQRNKEQED----IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQ 506
Query: 435 RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS 494
R + E +K + R I E + + +++M + P +I ++ + +
Sbjct: 507 RQEIESTNKSRELR--------IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQN 558
Query: 495 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 554
+ H R+S L +L K LE ++ Q L R K++ S
Sbjct: 559 SLH---RDS------LVTL-------KRALEAKELARQHL----RDQLDEVEKETRSKLQ 598
Query: 555 FIPADYLESTEEFIRRRHD------DKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 608
I D + + +R H+ K M R K + + + EL QK + ++
Sbjct: 599 EI--DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER 656
Query: 609 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 668
D+ W E + E +P+KL + L+ E++ K + + E
Sbjct: 657 DKQWLE---------------HVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEA 701
Query: 669 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 728
+ G L Q E +P V+ P+S++
Sbjct: 702 QDKLGR---LFHQHQEP-----------------------AKPAVQ-------APWSTAE 728
Query: 729 SRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI------- 781
T S Q+ + + Y+ALY + ++ DE+ ++ GDI
Sbjct: 729 KGPLTISAQE---------------NVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEW 773
Query: 782 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
VD + + GW G + + G FP NY + +
Sbjct: 774 VDESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
Score = 33.1 bits (74), Expect = 1.1
Identities = 40/165 (24%), Positives = 61/165 (36%), Gaps = 16/165 (9%)
Query: 51 PSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLP 110
P S + + R + GL P+P A W L AD N + + + S+ L
Sbjct: 34 PISGFITGDQARNFFFQSGL-PQPVLAQIWAL---ADMNNDGRMDQVEF----SIAMKLI 85
Query: 111 SDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEG--------TARPPTPLGPLGCVPTIPA 162
K Q SA P + P+ + + G TA P P+G + V P
Sbjct: 86 KLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPT 145
Query: 163 TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPP 207
S+ P L + PP +Q P + PA + S++ P
Sbjct: 146 LVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 83.2 bits (204), Expect = 9e-16
Identities = 76/288 (26%), Positives = 118/288 (40%), Gaps = 55/288 (19%)
Query: 534 LSGLKRPSSSASTKDSESPRHFI-----PADYLESTEEFIRRRHDDKEMRPARAKFDFKA 588
+SG R S+S + SESP A + S EEFI A + +++
Sbjct: 969 ISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFI-------------AMYTYES 1015
Query: 589 QTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPV-Q 647
+L Q+GD++ + K+ D +W+ G + G+FP Y+ L K + +
Sbjct: 1016 SEQGDLTFQQGDVILVTKK-DGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGK 1074
Query: 648 VLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIP--GTSRQ-GIFPITY 704
E + IA + G Q+ ++ G+ I + ++ W+EG + G RQ G FP Y
Sbjct: 1075 KPEIAQVIASYTATGPEQLTLA--PGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANY 1132
Query: 705 VDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALY 764
V ++ SP S + P +S + +Y
Sbjct: 1133 VKLL------------------SPGTSKITPTEPP----------KSTALAAVCQVIGMY 1164
Query: 765 SYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
Y QNDDEL G I++V+ K D W+ G Q G FP NYVK
Sbjct: 1165 DYTAQNDDELAFNKGQIINVLNKEDPDWWKG--EVNGQVGLFPSNYVK 1210
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/279 (23%), Positives = 118/279 (42%), Gaps = 54/279 (19%)
Query: 555 FIPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYE 614
F PA S+ + + + E A+A + ++A+ L K D++ + +Q D W+
Sbjct: 893 FTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF- 951
Query: 615 GEHHGRVGIFPRTYIELLP-PAEKA---------QPKKLTPV------QVLEYGEAIAKF 658
GE G+ G FP++Y++L+ P K+ P L V V+ E IA +
Sbjct: 952 GEVQGQKGWFPKSYVKLISGPIRKSTSMDSGSSESPASLKRVASPAAKPVVSGEEFIAMY 1011
Query: 659 NFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVD 718
+ Q +++F++G+ + L+ + D +W+ G + + G+FP YV +
Sbjct: 1012 TYESSEQGDLTFQQGD-VILVTKKDGDWWTGTV--GDKAGVFPSNYVRL----------- 1057
Query: 719 YMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRD 778
S TA ++ + Q + SY ++L L
Sbjct: 1058 -------KDSEGSGTAGKTGSLGKKPEIA-------------QVIASYTATGPEQLTLAP 1097
Query: 779 GDIVDVMEKCDDGWFVGTSR---RTKQFGTFPGNYVKPL 814
G ++ + +K GW+ G + + +Q G FP NYVK L
Sbjct: 1098 GQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLL 1136
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 30/242 (12%)
Query: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQ-IDQN------WYEGEHHGRVGIFPRTYIELLP 633
RA + F++++ E+ +Q GDIV + + +D++ W GE G+ G FP Y E +P
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIP 805
Query: 634 PAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENW--YEGRI 691
E P K V + A A +T ++ E T NW +
Sbjct: 806 ENEVPAPVK----PVTDSTSAPAPKLALRETPAPLAVTSSEPST----TPNNWADFSSTW 857
Query: 692 PGTSRQGIFPITYVDVIKRPLVKNP-VDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDR 750
P ++ + + +P + P + + +P+ + +SP Q +V
Sbjct: 858 PTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKV---- 913
Query: 751 SQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNY 810
+ QALY + + D+ L D++ V+E+ D WF Q G FP +Y
Sbjct: 914 -----EGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF---GEVQGQKGWFPKSY 965
Query: 811 VK 812
VK
Sbjct: 966 VK 967
Score = 49.7 bits (117), Expect = 1e-05
Identities = 20/56 (35%), Positives = 35/56 (62%)
Query: 584 FDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 639
+D+ AQ EL KG I+ + + D +W++GE +G+VG+FP Y++L + +Q
Sbjct: 1164 YDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTDMDPSQ 1219
Score = 41.6 bits (96), Expect = 0.003
Identities = 118/633 (18%), Positives = 225/633 (35%), Gaps = 145/633 (22%)
Query: 208 SFSPPPPLVPPA--PEDLRRVSEPDLTGAVSSTD------SSPLLNEVSSSLIGTDSQAF 259
S P PP++PP P RRV +SST P+L + L F
Sbjct: 291 SGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEPVLEDEQQQLEKKLPVTF 350
Query: 260 PSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDSAPTQ-----E 314
+ + + + LL+ R++Q+RL+ L ER+ E+ + E
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
Query: 315 KPTSPGKAIEKRAKDDSRRVVKSTQDLSDVSMDEVGIPLRNTERSKDWYKTMFKQIHKLN 374
K + +E++ +++ R+ ++ E +R +W
Sbjct: 411 KQLEKQRELERQREEERRK---------EIERREAAKRELERQRQLEW-----------E 450
Query: 375 RDDDSDLYSPRYSFSEDTKSPLSVPRSKSEMSYIDGEKVVKRSATLPLPARSSSLKSSSE 434
R+ +L + R ED + V ++K + + E + + L + + +++
Sbjct: 451 RNRRQELLNQRNKEQED----IVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQ 506
Query: 435 RNDWEPPDKKVDTRKYRAEPKSIYEYQPGKSSVLTNEKMSSAISPTPEISSETPGYIYSS 494
R + E +K + R I E + + +++M + P +I ++ + +
Sbjct: 507 RQEIESTNKSRELR--------IAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQN 558
Query: 495 NFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRH 554
+ H R+S L +L K LE ++ Q L R K++ S
Sbjct: 559 SLH---RDS------LVTL-------KRALEAKELARQHL----RDQLDEVEKETRSKLQ 598
Query: 555 FIPADYLESTEEFIRRRHD------DKEMRPARAKFDFKAQTLKELPLQKGDIVYIYKQI 608
I D + + +R H+ K M R K + + + EL QK + ++
Sbjct: 599 EI--DIFNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRAQER 656
Query: 609 DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEM 668
D+ W E + E +P+KL + L+ E++ K + + E
Sbjct: 657 DKQWLE---------------HVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEA 701
Query: 669 SFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSP 728
+ G L Q E +P V+ P+S++
Sbjct: 702 QDKLGR---LFHQHQEP-----------------------AKPAVQ-------APWSTAE 728
Query: 729 SRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDI------- 781
T S Q+ + + Y+ALY + ++ DE+ ++ GDI
Sbjct: 729 KGPLTISAQE---------------NVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEW 773
Query: 782 VDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
VD + + GW G + + G FP NY + +
Sbjct: 774 VDESQTGEPGWLGGELK--GKTGWFPANYAEKI 804
Score = 33.1 bits (74), Expect = 1.1
Identities = 40/165 (24%), Positives = 61/165 (36%), Gaps = 16/165 (9%)
Query: 51 PSSSPASPQETRQHESKPGLEPEPSSADEWRLSSSADANGNAQPSSLAAKGYRSVHPNLP 110
P S + + R + GL P+P A W L AD N + + + S+ L
Sbjct: 34 PISGFITGDQARNFFFQSGL-PQPVLAQIWAL---ADMNNDGRMDQVEF----SIAMKLI 85
Query: 111 SDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEG--------TARPPTPLGPLGCVPTIPA 162
K Q SA P + P+ + + G TA P P+G + V P
Sbjct: 86 KLKLQGYQLPSALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVVGMSPT 145
Query: 163 TASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPP 207
S+ P L + PP +Q P + PA + S++ P
Sbjct: 146 LVSSVPTAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGP 190
>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
Length = 888
Score = 81.6 bits (200), Expect = 3e-15
Identities = 49/173 (28%), Positives = 93/173 (53%), Gaps = 23/173 (13%)
Query: 580 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 639
A+A ++++ + +L KGDI+ + +Q+D+NWY GE +G G FP +++++ P +
Sbjct: 139 AKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIHGFFPTNFVQIIKPLPQPP 198
Query: 640 PKKLTPVQVLEYGEAIAKFNFN-GDTQVE---MSFRKGERITLLRQVDENWYEGRIPGTS 695
P + A ++F D + + + F K + +T++R+VDENW EG +
Sbjct: 199 P------------QCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGML--AD 244
Query: 696 RQGIFPITYVDV--IKRPLV---KNPVDYMDLPFSSSPSRSATASPQQPQAQQ 743
+ GIFPI+YV+ + L+ K PV +D SS + ++ +P+ ++
Sbjct: 245 KIGIFPISYVEFNSAAKQLIEWDKPPVPGVDAGECSSAAAQSSTAPKHSDTKK 297
Score = 77.4 bits (189), Expect = 5e-14
Identities = 40/104 (38%), Positives = 58/104 (55%), Gaps = 2/104 (1%)
Query: 711 PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQN 770
PL+ V P +++ + +A P+ ++ R QT + Y A+Y Y P+
Sbjct: 403 PLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLRPQTRPSV--YVAIYPYTPRK 460
Query: 771 DDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
+DELELR G++ V E+C DGWF GTS T + G FPGNYV P+
Sbjct: 461 EDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPV 504
Score = 59.3 bits (142), Expect = 1e-08
Identities = 26/53 (49%), Positives = 40/53 (75%)
Query: 760 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
++ + SY PQ++ ELEL++GDIV V +K +DGWF GT +R + G FPG++V+
Sbjct: 834 HRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVE 886
Score = 46.6 bits (109), Expect = 9e-05
Identities = 44/191 (23%), Positives = 77/191 (40%), Gaps = 41/191 (21%)
Query: 474 SSAISPTPEISSETPGYIYSSNFHAVKRESDGAPGDLTSLENERQIYKSVLEGGDIPLQG 533
SSA P + E G + + + KR+ +P +LE E L ++PLQG
Sbjct: 703 SSATKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLEVE-------LGSAELPLQG 755
Query: 534 LSGLKRPSSSASTK------DSESPRHFIPADYLESTEEFIRRRHDD------------- 574
G + P + D + P A + + F R+
Sbjct: 756 AVGPELPPGGGHGRAGSCPVDGDGPVTTAVAGAALAQDAFHRKASSLDSAVPIAPPPRQA 815
Query: 575 --------KEMRPA-----RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEG--EHHG 619
E RP R + Q+ EL L++GDIV+++K+ + W++G + +G
Sbjct: 816 CSSLGPVLNESRPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNG 875
Query: 620 RVGIFPRTYIE 630
+ G+FP +++E
Sbjct: 876 KTGLFPGSFVE 886
Score = 38.9 bits (89), Expect = 0.019
Identities = 19/79 (24%), Positives = 36/79 (45%)
Query: 655 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVK 714
+A + + + E+ RKGE + + + W++G TS+ G+FP YV + R +
Sbjct: 451 VAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTRAVTN 510
Query: 715 NPVDYMDLPFSSSPSRSAT 733
+ + + SR T
Sbjct: 511 ASQAKVPMSTAGQTSRGVT 529
Score = 37.0 bits (84), Expect = 0.074
Identities = 56/238 (23%), Positives = 91/238 (38%), Gaps = 35/238 (14%)
Query: 421 PLPARSSSLKSSSERNDWEPPDKKVDTRKYRAEPKSIYEY-QPGKSSVLTNEKMSSAISP 479
P+P + SS+ P K DT+K + S KSS + + S ISP
Sbjct: 270 PVPGVDAGECSSAAAQSSTAP-KHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISP 328
Query: 480 TPEISSETPGYIYSSNFHAVKRESDGAPGDL----TSLENERQIYKSVLEG------GDI 529
ISS P ++ + S AP + T L V G D+
Sbjct: 329 PVLISSSNP--TAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPSFTFPSDV 386
Query: 530 PLQGLSG-----LKRPSSSASTKDSESPRHFI---------PADYLESTEEFIRRRHDDK 575
P Q G L P A+T + +P P ST++ R
Sbjct: 387 PYQAALGTLNPPLPPPPLLAATVLASTPPGATAAAAAAGMGPRPMAGSTDQIAHLR---P 443
Query: 576 EMRPAR--AKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGE--HHGRVGIFPRTYI 629
+ RP+ A + + + EL L+KG++ ++++ W++G H ++G+FP Y+
Sbjct: 444 QTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYV 501
Score = 33.1 bits (74), Expect = 1.1
Identities = 19/57 (33%), Positives = 30/57 (52%), Gaps = 5/57 (8%)
Query: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYV---KPL 814
+ALY+Y + +L+ GDI+ + + D+ W+ G G FP N+V KPL
Sbjct: 140 KALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGI--HGFFPTNFVQIIKPL 194
Score = 31.2 bits (69), Expect = 4.1
Identities = 9/45 (20%), Positives = 29/45 (64%)
Query: 664 TQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVI 708
++ E+ ++G+ + + ++ ++ W++G + + G+FP ++V+ I
Sbjct: 844 SEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI 888
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 80.9 bits (198), Expect = 4e-15
Identities = 70/236 (29%), Positives = 106/236 (44%), Gaps = 26/236 (11%)
Query: 580 ARAKFDFKAQTLKELPLQKGDIVYIY-KQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKA 638
A AK+DFKA EL ++GDI+ + ++ DQNWY+ E +G+ G P+ YIE+ P
Sbjct: 3 AIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKP----- 57
Query: 639 QPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQG 698
P + + E ++K +G + S +L + + ++ R G
Sbjct: 58 HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV---LRDG 114
Query: 699 IFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLF 758
++ V+K + VDY S+S SR+ Q+ D Q Q
Sbjct: 115 AGKY-FLWVVKFNSLNELVDYHR---STSVSRN-----------QQIFLRDIEQVPQQPT 159
Query: 759 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
QAL+ + PQ D EL R GD + VM+ D W+ G Q G FP NYV P+
Sbjct: 160 YVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACH--GQTGMFPRNYVTPV 213
Score = 44.3 bits (103), Expect = 5e-04
Identities = 20/60 (33%), Positives = 36/60 (60%), Gaps = 3/60 (5%)
Query: 653 EAIAKFNFNGDTQVEMSFRKGERITLL-RQVDENWYEGRIPGTSRQGIFPITYVDVIKRP 711
EAIAK++F E+SF++G+ + +L + D+NWY+ + G + G P Y+++ P
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNG--KDGFIPKNYIEMKPHP 59
Score = 38.9 bits (89), Expect = 0.019
Identities = 19/55 (34%), Positives = 31/55 (56%), Gaps = 2/55 (3%)
Query: 656 AKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR 710
A F+F+ E+ FR+G+ I ++ D NW++G G + G+FP YV + R
Sbjct: 163 ALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHG--QTGMFPRNYVTPVNR 215
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 80.5 bits (197), Expect = 6e-15
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 585 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 642
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
Query: 643 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 699
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
Query: 700 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 758
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
Query: 759 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
Score = 70.5 bits (171), Expect = 6e-12
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 577 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 636
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
Query: 637 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 672
TPV E G +A + F E+ F
Sbjct: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
Query: 673 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 730
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
Score = 58.9 bits (141), Expect = 2e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
Query: 641 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 700
++L + F + +G+ + L W +GR +R G F
Sbjct: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
Query: 701 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 760
P + V + L S S +A Q P+ +
Sbjct: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
Query: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 79.7 bits (195), Expect = 1e-14
Identities = 80/293 (27%), Positives = 122/293 (41%), Gaps = 55/293 (18%)
Query: 556 IPADYLESTEEFIRRRHDDKEMRPARAKFDFKAQTLKE----LPLQKGDIVYIYKQIDQN 611
I ++ S+ E I++ + A FD + + E L K DI+ + ++D+N
Sbjct: 170 ISGNFPASSVEVIKQLPQPPPLCRALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDEN 229
Query: 612 WYEGEHHGRVGIFPRTYIELLPPAEKAQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFR 671
W EG+ +VGIFP ++E LT +LE + + V S R
Sbjct: 230 WAEGKLGDKVGIFPILFVE----------PNLTARHLLEKNKGRQSSRTKNLSLVSSSSR 279
Query: 672 KGERITLLRQVDENWYEGRIPGTSRQ--GIFPIT----------------YVDVIKRPL- 712
G TL R PG+ R+ G F IT ++ I P+
Sbjct: 280 -GNTSTLRRG----------PGSRRKVPGQFSITTALNTLNRMVHSPSGRHMVEISTPVL 328
Query: 713 --------VKNPVDYMDLPFSSSPSRSAT--ASPQQPQAQQRRVTPDRSQTSQDLFSYQA 762
+ P++ D+P SS + +T +P P V+ SQ + A
Sbjct: 329 ISSSNPSVITQPMEKADVP-SSCVGQVSTYHPAPVSPGHSTAVVSLPGSQQHLSANMFVA 387
Query: 763 LYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPLY 815
L+SY DEL+L+ G+ V V+ KC DGW G S T + G FP NYV P++
Sbjct: 388 LHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIF 440
Score = 79.3 bits (194), Expect = 1e-14
Identities = 54/186 (29%), Positives = 98/186 (52%), Gaps = 23/186 (12%)
Query: 580 ARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQ 639
A+A +++ Q +L KGDI+ + +Q+D+NWY+GE +G G FP + +E++ + Q
Sbjct: 130 AKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEINGISGNFPASSVEVI--KQLPQ 187
Query: 640 PKKLTPVQVLEYGEAIAKFNFNGDTQVE----MSFRKGERITLLRQVDENWYEGRIPGTS 695
P L A+ F+ G + E ++F K + IT++ +VDENW EG++
Sbjct: 188 PPPLC--------RALYNFDLRGKDKSENQDCLTFLKDDIITVISRVDENWAEGKL--GD 237
Query: 696 RQGIFPITYVD-------VIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTP 748
+ GIFPI +V+ ++++ + +L SS SR T++ ++ +R+V
Sbjct: 238 KVGIFPILFVEPNLTARHLLEKNKGRQSSRTKNLSLVSSSSRGNTSTLRRGPGSRRKVPG 297
Query: 749 DRSQTS 754
S T+
Sbjct: 298 QFSITT 303
Score = 36.6 bits (83), Expect = 0.096
Identities = 22/83 (26%), Positives = 39/83 (46%), Gaps = 2/83 (2%)
Query: 730 RSATASPQQPQAQQRRVTPDRSQTSQDLFSYQALYSYIPQNDDELELRDGDIVDVMEKCD 789
R + +P++ QA R+ P+ + +AL +Y QN +L GDI+ + + D
Sbjct: 100 RKSRTNPRRLQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLD 159
Query: 790 DGWFVGTSRRTKQFGTFPGNYVK 812
+ W+ G G FP + V+
Sbjct: 160 ENWYQGEINGIS--GNFPASSVE 180
Score = 34.7 bits (78), Expect = 0.37
Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 6/96 (6%)
Query: 655 IAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKR---- 710
+A +++ E+ +KGE + +L + + W G T R GIFP YV I R
Sbjct: 386 VALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLRGVSLVTGRVGIFPNNYVIPIFRKTSS 445
Query: 711 -PLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRR 745
P ++P Y S+S S S+ S + +Q R
Sbjct: 446 FPDSRSPGLYTTWTLSTS-SVSSQGSISEGDPRQSR 480
>gi|11321634 CD2-associated protein [Homo sapiens]
Length = 639
Score = 78.6 bits (192), Expect = 2e-14
Identities = 56/175 (32%), Positives = 91/175 (52%), Gaps = 29/175 (16%)
Query: 655 IAKFNFNGDTQVEMSFRKGERITLLRQV-DENWYEGRIPGTSRQGIFPITYVDVIKRPLV 713
I +++++ E++ R GE I ++++ +E W EG + G R+G+FP +V IKR
Sbjct: 5 IVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNG--RRGMFPDNFVKEIKRE-- 60
Query: 714 KNPVDYMD--LPF--------SSSPSRSAT----ASPQQPQAQQRRVTPDRSQTSQDLFS 759
++ D LP +S R +T A QP Q + + +
Sbjct: 61 ---TEFKDDSLPIKRERHGNVASLVQRISTYGLPAGGIQPHPQTKNIKKKTKKRQ----- 112
Query: 760 YQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
+ L+ YIPQN+DELEL+ GDI+D+ E+ ++GW+ GT + G FP N+VK L
Sbjct: 113 CKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT--LNNKLGLFPSNFVKEL 165
Score = 53.5 bits (127), Expect = 8e-07
Identities = 56/244 (22%), Positives = 106/244 (43%), Gaps = 41/244 (16%)
Query: 578 RPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEK 637
R + F++ Q EL L+ GDI+ I +++++ W+ G + ++G+FP +++ L
Sbjct: 111 RQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKEL----- 165
Query: 638 AQPKKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQ 697
+V + GE D++ ++ I L V E G + T +
Sbjct: 166 ---------EVTDDGET---HEAQDDSETVLA-GPTSPIPSLGNVSET-ASGSV--TQPK 209
Query: 698 GIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQ--------PQAQQRRVTPD 749
I I + D+ K VK L +S S + P++ P+ Q +T
Sbjct: 210 KIRGIGFGDIFKEGSVK-------LRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKT 262
Query: 750 RSQTSQDLFSY-QALYSYIPQNDDELELRDGDIVDVMEK--CDDGWFVGTSRRTKQFGTF 806
++ Y + L++Y N+DEL ++G+I+ ++ K + GW+ G + G F
Sbjct: 263 DTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKE--GVF 320
Query: 807 PGNY 810
P N+
Sbjct: 321 PDNF 324
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/125 (23%), Positives = 56/125 (44%), Gaps = 6/125 (4%)
Query: 527 GDIPLQGLSGLKRPSSSASTKDSESPRHFIPADYLESTEEFIRRRHDD----KEMRPARA 582
GDI +G L+ +SS+ T++ + + I T+ + D K R
Sbjct: 217 GDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRT 276
Query: 583 KFDFKAQTLKELPLQKGDIVYIYKQI--DQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640
F ++ EL ++G+I+++ + + W+ GE +G+ G+FP + + +K P
Sbjct: 277 LFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFP 336
Query: 641 KKLTP 645
K P
Sbjct: 337 KPKKP 341
Score = 36.6 bits (83), Expect = 0.096
Identities = 20/59 (33%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 757 LFSYQALYSYIPQNDDELELRDGDIVDVMEKC-DDGWFVGTSRRTKQFGTFPGNYVKPL 814
+ Y Y Y +DDEL +R G+I+ ++K ++GW G + G FP N+VK +
Sbjct: 1 MVDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRR--GMFPDNFVKEI 57
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,085,615
Number of Sequences: 37866
Number of extensions: 1949314
Number of successful extensions: 14380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 248
Number of HSP's successfully gapped in prelim test: 744
Number of HSP's that attempted gapping in prelim test: 10250
Number of HSP's gapped (non-prelim): 3515
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.