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Search of human proteins with 7657562
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657562 SH3-domain binding protein 4 [Homo sapiens]
(963 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657562 SH3-domain binding protein 4 [Homo sapiens] 1942 0.0
gi|157502191 putative binding protein 7a5 [Homo sapiens] 638 0.0
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 54 9e-07
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 54 9e-07
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 53 1e-06
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 49 2e-05
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 49 2e-05
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 49 2e-05
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 47 7e-05
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 47 1e-04
gi|46255049 HMT1 hnRNP methyltransferase-like 1 [Homo sapiens] 46 2e-04
gi|46255047 HMT1 hnRNP methyltransferase-like 1 [Homo sapiens] 46 2e-04
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 43 0.001
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 43 0.001
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 43 0.001
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 43 0.002
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 43 0.002
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 43 0.002
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 43 0.002
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 43 0.002
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 42 0.002
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 42 0.002
gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens] 42 0.003
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 41 0.005
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 41 0.005
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 41 0.005
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 41 0.005
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 41 0.005
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 41 0.005
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 41 0.005
>gi|7657562 SH3-domain binding protein 4 [Homo sapiens]
Length = 963
Score = 1942 bits (5030), Expect = 0.0
Identities = 963/963 (100%), Positives = 963/963 (100%)
Query: 1 MAAQRIRAANSNGLPRCKSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKEV 60
MAAQRIRAANSNGLPRCKSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKEV
Sbjct: 1 MAAQRIRAANSNGLPRCKSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKEV 60
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLS 120
IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLS
Sbjct: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLS 120
Query: 121 DSGMIDNLPDSPDEVAKELELLGGWTDDKKVPGRMYSNNPFWNGVQTNPFLNGNVPVMPS 180
DSGMIDNLPDSPDEVAKELELLGGWTDDKKVPGRMYSNNPFWNGVQTNPFLNGNVPVMPS
Sbjct: 121 DSGMIDNLPDSPDEVAKELELLGGWTDDKKVPGRMYSNNPFWNGVQTNPFLNGNVPVMPS 180
Query: 181 LDELNPKSTVDLLLFDAGTSSFTESSSATTNSTGNIFDELPVTNGLHAEPPVRRDNPFFR 240
LDELNPKSTVDLLLFDAGTSSFTESSSATTNSTGNIFDELPVTNGLHAEPPVRRDNPFFR
Sbjct: 181 LDELNPKSTVDLLLFDAGTSSFTESSSATTNSTGNIFDELPVTNGLHAEPPVRRDNPFFR 240
Query: 241 SKRSYSLSELSVLQAKSDAPTSSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDL 300
SKRSYSLSELSVLQAKSDAPTSSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDL
Sbjct: 241 SKRSYSLSELSVLQAKSDAPTSSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDL 300
Query: 301 DLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDTSISIHVPEGHVAPGETQQISMKALL 360
DLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDTSISIHVPEGHVAPGETQQISMKALL
Sbjct: 301 DLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDTSISIHVPEGHVAPGETQQISMKALL 360
Query: 361 DPPLELNSDRSCSISPVLEVKLSNLEVKTSIILEMKVSAEIKNDLFSKSTVGLQCLRSDS 420
DPPLELNSDRSCSISPVLEVKLSNLEVKTSIILEMKVSAEIKNDLFSKSTVGLQCLRSDS
Sbjct: 361 DPPLELNSDRSCSISPVLEVKLSNLEVKTSIILEMKVSAEIKNDLFSKSTVGLQCLRSDS 420
Query: 421 KEGPYVSVPLNCSCGDTVQAQLHNLEPCMYVAVVAHGPSILYPSTVWDFINKKVTVGLYG 480
KEGPYVSVPLNCSCGDTVQAQLHNLEPCMYVAVVAHGPSILYPSTVWDFINKKVTVGLYG
Sbjct: 421 KEGPYVSVPLNCSCGDTVQAQLHNLEPCMYVAVVAHGPSILYPSTVWDFINKKVTVGLYG 480
Query: 481 PKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPNPAPVALQLWGKHQFVLSRPQDLKVC 540
PKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPNPAPVALQLWGKHQFVLSRPQDLKVC
Sbjct: 481 PKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPNPAPVALQLWGKHQFVLSRPQDLKVC 540
Query: 541 MFSNMTNYEVKASEQAKVVRGFQLKLGKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAI 600
MFSNMTNYEVKASEQAKVVRGFQLKLGKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAI
Sbjct: 541 MFSNMTNYEVKASEQAKVVRGFQLKLGKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAI 600
Query: 601 LTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGK 660
LTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGK
Sbjct: 601 LTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGK 660
Query: 661 LLKTVVRQNKNHYLLEYKKGDGIALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVL 720
LLKTVVRQNKNHYLLEYKKGDGIALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVL
Sbjct: 661 LLKTVVRQNKNHYLLEYKKGDGIALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVL 720
Query: 721 VVGRARPSLCSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVN 780
VVGRARPSLCSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVN
Sbjct: 721 VVGRARPSLCSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVN 780
Query: 781 LPLTFFCRAELDSEPERVASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRL 840
LPLTFFCRAELDSEPERVASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRL
Sbjct: 781 LPLTFFCRAELDSEPERVASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRL 840
Query: 841 IQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLL 900
IQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLL
Sbjct: 841 IQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLL 900
Query: 901 TWSHQIGDSYRDVIQELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQDD 960
TWSHQIGDSYRDVIQELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQDD
Sbjct: 901 TWSHQIGDSYRDVIQELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQDD 960
Query: 961 FVI 963
FVI
Sbjct: 961 FVI 963
>gi|157502191 putative binding protein 7a5 [Homo sapiens]
Length = 852
Score = 638 bits (1645), Expect = 0.0
Identities = 361/826 (43%), Positives = 504/826 (61%), Gaps = 25/826 (3%)
Query: 140 ELLGGWTDDKKVPGRMYSN--NPFWNGVQ-TNPFLNGNVPVMPSLDELNPKSTVDLLLFD 196
+LL W D + G S NPFWN + +NPFL+ + L ++ + +L D
Sbjct: 44 DLLHNWPDAFTLRGNNASKVANPFWNQLSASNPFLDD----ITQLRNNRKRNNISILKED 99
Query: 197 AGTSSFTESSSATTNSTGNIFDELPVTNGLHAEPPVRRDNPFFRSKRSYSLSEL-SVLQA 255
+ + +S+G DEL V L R S RS S+SEL +L
Sbjct: 100 PFLFCREIENGNSFDSSG---DELDVHQLL-------RQTSSRNSGRSKSVSELLDILDD 149
Query: 256 KSDAPTSSSFFTGLKSPAPEQFQS-REDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQA 314
+ A S + E ++ RE ++ AWL+ R+LARSC DL+ + QSPGW QTQ
Sbjct: 150 TAHAHQSIHNSDQILLHDLEWLKNDREAYKMAWLSQRQLARSCLDLNTISQSPGWAQTQL 209
Query: 315 VETNIVCKLDSSGGAVQLPDTSISIHVPEGHVAPGETQQISMKALLDPPLELNSDRSCSI 374
E I CK++ GG+VQLP++ I++HVP+GHVA GE Q++S++A LDPP LN D SC++
Sbjct: 210 AEVTIACKVNHQGGSVQLPESDITVHVPQGHVAVGEFQEVSLRAFLDPPHMLNHDLSCTV 269
Query: 375 SPVLEVKLSNLEVKTSIILEMKVSAEIKNDLFSKSTVGLQCLRSDSKEGPYVSVPLNCSC 434
SP+LE+ L NL +++LEMK+ AE++ D FS+ + CL S KEGP+ V NC
Sbjct: 270 SPLLEIMLGNLNTMEALLLEMKIGAEVRKDPFSQVMTEMVCLHSLGKEGPF-KVLSNCYI 328
Query: 435 -GDTVQAQLHNLEPCMYVAVVAHGPSILYPS-TVWDFINKKVTVGLYGPKHIHPSFKTVV 492
DT+Q +L +L MY+ V A ++ P+ T+WD+I+K ++G+YGPK+IHPSF V+
Sbjct: 329 YKDTIQVKLIDLSQVMYLVVAAQAKALPSPAATIWDYIHKTTSIGIYGPKYIHPSFTVVL 388
Query: 493 TIFGHDCAPKTLLVSEVTRQAPNPAPVALQLWGKHQFVLSRPQDLKVCMFSNMTNYEVKA 552
T+ GH+ P L +S++ + N +PV QLWGK F+L +PQDL + +FS ++EVK
Sbjct: 389 TVCGHNYMPGQLTISDIKKGGKNISPVVFQLWGKQSFLLDKPQDLSISIFSCDPDFEVKT 448
Query: 553 SEQAKVVRGFQLKLGKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAILTQFCVQTPQPP 612
+ K ++ QL+ G+V F + E+ F VQV+ + QF + TP P
Sbjct: 449 EGERKEIKQKQLEAGEVVHQQFLFSLVEHREMHLFDFCVQVEPPNGEPVAQFSITTPDPT 508
Query: 613 PKSAIKPSGQRRFLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGKLLKTVVRQNKNH 672
P + KK E+ LSP KYPTFQD+ ++ +G LK V+RQ+K
Sbjct: 509 PNLKRLSNLPGYLQKKEEIKSAPLSP-KILVKYPTFQDKTLNFSNYGVTLKAVLRQSKID 567
Query: 673 YLLEYKKGDGIALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVLVVGRARPSLCSG 732
Y LEY KGD IALL E +V+ GQ KEWY+G +G++GLVH KNV V+ + + S
Sbjct: 568 YFLEYFKGDTIALLGEGKVKAIGQSKVKEWYVGVLRGKIGLVHCKNVKVISKEQVMFMSD 627
Query: 733 PELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVNLPLTFFCRAELD 792
+T LLEQI+ P K LTYIY+ V TL+ E + W+ AD LGY +L L F + + D
Sbjct: 628 SVFTTRNLLEQIVLPLKKLTYIYSVVLTLVSEKVYDWKVLADVLGYSHLSLEDFDQIQAD 687
Query: 793 SEPERVASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVE 852
E E+V+ V++KLKEDC+ TE RK F EL++ALLKMDCQ LV RLIQ+ +LT+AV+
Sbjct: 688 KESEKVSYVIKKLKEDCH-TERNTRK-FLYELIVALLKMDCQELVARLIQEAAVLTSAVK 745
Query: 853 VAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRD 912
+ + WRELAEKL +++KQQM+AYE PHR G V E MWKPAYDFL TWS G++YRD
Sbjct: 746 LGKGWRELAEKLVRLTKQQMEAYEIPHRGNTGDVAVEMMWKPAYDFLYTWSAHYGNNYRD 805
Query: 913 VIQELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQ 958
V+Q+L LD+MKNP+TK W+ LTG LILVNSL+VLR AFS +++
Sbjct: 806 VLQDLQSALDRMKNPVTKHWRELTGVLILVNSLEVLRVTAFSTSEE 851
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 53.5 bits (127), Expect = 9e-07
Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 2/59 (3%)
Query: 55 GNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAH--NTTEMGYIPSSYVQP 111
G +A+ DY T L F KG+ L +++ + G+WW AH +T + GYIPS+YV P
Sbjct: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 53.5 bits (127), Expect = 9e-07
Identities = 24/59 (40%), Positives = 35/59 (59%), Gaps = 2/59 (3%)
Query: 55 GNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAH--NTTEMGYIPSSYVQP 111
G +A+ DY T L F KG+ L +++ + G+WW AH +T + GYIPS+YV P
Sbjct: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 53.1 bits (126), Expect = 1e-06
Identities = 27/70 (38%), Positives = 38/70 (54%), Gaps = 5/70 (7%)
Query: 41 PSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT- 99
P P+A P K+V+A+ DY P N L+ KGD ++L+ S WW A +
Sbjct: 204 PEPAAA----PVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNG 259
Query: 100 EMGYIPSSYV 109
+ GYIPS+YV
Sbjct: 260 QEGYIPSNYV 269
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/55 (41%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
+A+ DY L F KG+ +L++S G+WW A + T E GYIPS+YV P++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/55 (41%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
+A+ DY L F KG+ +L++S G+WW A + T E GYIPS+YV P++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 49.3 bits (116), Expect = 2e-05
Identities = 23/55 (41%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
+A+ DY L F KG+ +L++S G+WW A + T E GYIPS+YV P++
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 47.4 bits (111), Expect = 7e-05
Identities = 25/52 (48%), Positives = 33/52 (63%), Gaps = 3/52 (5%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHN--TTEMGYIPSSYV 109
V+A+ DY + L F KGD + VL+ S GEWW A + T + GYIPS+YV
Sbjct: 83 VVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYV 133
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 46.6 bits (109), Expect = 1e-04
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 9/85 (10%)
Query: 29 GFSETSFNDIKVPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTS 88
G + +SF+ + P+ L G +A+ DY L F KG+ +++ +
Sbjct: 72 GGASSSFSVVPSSYPAGLT-------GGVTIFVALYDYEARTTEDLSFKKGERFQIINNT 124
Query: 89 GGEWWYAHN--TTEMGYIPSSYVQP 111
G+WW A + T + GYIPS+YV P
Sbjct: 125 EGDWWEARSIATGKNGYIPSNYVAP 149
>gi|46255049 HMT1 hnRNP methyltransferase-like 1 [Homo sapiens]
Length = 433
Score = 45.8 bits (107), Expect = 2e-04
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 4/68 (5%)
Query: 42 SPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEM 101
S + LL + P +E +AI DY T+ T L F +G+ + +L + +WW+
Sbjct: 21 SEAGLLQEGVQP----EEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCC 76
Query: 102 GYIPSSYV 109
GYIP+++V
Sbjct: 77 GYIPANHV 84
>gi|46255047 HMT1 hnRNP methyltransferase-like 1 [Homo sapiens]
Length = 433
Score = 45.8 bits (107), Expect = 2e-04
Identities = 22/68 (32%), Positives = 37/68 (54%), Gaps = 4/68 (5%)
Query: 42 SPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEM 101
S + LL + P +E +AI DY T+ T L F +G+ + +L + +WW+
Sbjct: 21 SEAGLLQEGVQP----EEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCC 76
Query: 102 GYIPSSYV 109
GYIP+++V
Sbjct: 77 GYIPANHV 84
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/55 (36%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
IA+ DY L F+KG+ ++L+ + G+WW A + + + G IPS+YV P++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/55 (36%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
IA+ DY L F+KG+ ++L+ + G+WW A + + + G IPS+YV P++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 43.1 bits (100), Expect = 0.001
Identities = 20/55 (36%), Positives = 34/55 (61%), Gaps = 2/55 (3%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
IA+ DY L F+KG+ ++L+ + G+WW A + + + G IPS+YV P++
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVD 137
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/137 (26%), Positives = 60/137 (43%), Gaps = 8/137 (5%)
Query: 18 KSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKE-VIAIKDYCPTNFTTLKF 76
K E + DLS S S ++ + S PT KE V+A+ DY + +
Sbjct: 931 KHEALMSDLSAYGS--SIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTM 988
Query: 77 SKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVA 136
KGD L +L+++ +WW G++P++YV+ L+ + S +NL + +A
Sbjct: 989 KKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD-----PAQSASRENLLEEQGSIA 1043
Query: 137 KELELLGGWTDDKKVPG 153
E + T K G
Sbjct: 1044 LRQEQIDNQTRITKEAG 1060
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 42.7 bits (99), Expect = 0.002
Identities = 36/137 (26%), Positives = 60/137 (43%), Gaps = 8/137 (5%)
Query: 18 KSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKE-VIAIKDYCPTNFTTLKF 76
K E + DLS S S ++ + S PT KE V+A+ DY + +
Sbjct: 931 KHEALMSDLSAYGS--SIQALREQAQSCRQQVAPTDDETGKELVLALYDYQEKSPREVTM 988
Query: 77 SKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVA 136
KGD L +L+++ +WW G++P++YV+ L+ + S +NL + +A
Sbjct: 989 KKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD-----PAQSASRENLLEEQGSIA 1043
Query: 137 KELELLGGWTDDKKVPG 153
E + T K G
Sbjct: 1044 LRQEQIDNQTRITKEAG 1060
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 42.7 bits (99), Expect = 0.002
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 38 IKVPSPSALLVDNPTP-FGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAH 96
+K+ PS+ + TP F +VIA+ DY N L FSKG + V++ +WW
Sbjct: 1085 VKLLGPSS---ERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1141
Query: 97 NTTEMGYIPSSYVQ 110
G PS+YV+
Sbjct: 1142 INGVTGLFPSNYVK 1155
Score = 38.5 bits (88), Expect = 0.031
Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 36 NDIKVPSPSALLV---DNPTP--FGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGG 90
+++K P AL PT + +E IA+ Y L F++G+ + V G
Sbjct: 930 SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDG- 988
Query: 91 EWWYAHNTTEMGYIPSSYVQPLNYRN-STLSDSGMIDNLPD 130
EWW G PS+YV+P + + + S SG + P+
Sbjct: 989 EWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPE 1029
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 42.7 bits (99), Expect = 0.002
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 38 IKVPSPSALLVDNPTP-FGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAH 96
+K+ PS+ + TP F +VIA+ DY N L FSKG + V++ +WW
Sbjct: 1112 VKLLGPSS---ERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1168
Query: 97 NTTEMGYIPSSYVQ 110
G PS+YV+
Sbjct: 1169 INGVTGLFPSNYVK 1182
Score = 38.5 bits (88), Expect = 0.031
Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 36 NDIKVPSPSALLV---DNPTP--FGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGG 90
+++K P AL PT + +E IA+ Y L F++G+ + V G
Sbjct: 957 SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDG- 1015
Query: 91 EWWYAHNTTEMGYIPSSYVQPLNYRN-STLSDSGMIDNLPD 130
EWW G PS+YV+P + + + S SG + P+
Sbjct: 1016 EWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPE 1056
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 42.7 bits (99), Expect = 0.002
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 4/74 (5%)
Query: 38 IKVPSPSALLVDNPTP-FGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAH 96
+K+ PS+ + TP F +VIA+ DY N L FSKG + V++ +WW
Sbjct: 1112 VKLLGPSS---ERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1168
Query: 97 NTTEMGYIPSSYVQ 110
G PS+YV+
Sbjct: 1169 INGVTGLFPSNYVK 1182
Score = 38.5 bits (88), Expect = 0.031
Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 36 NDIKVPSPSALLV---DNPTP--FGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGG 90
+++K P AL PT + +E IA+ Y L F++G+ + V G
Sbjct: 957 SEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDG- 1015
Query: 91 EWWYAHNTTEMGYIPSSYVQPLNYRN-STLSDSGMIDNLPD 130
EWW G PS+YV+P + + + S SG + P+
Sbjct: 1016 EWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPE 1056
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/56 (41%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
VIA+ Y P++ L F KG+ L +L+ S GEWW A + T + G+IP ++V N
Sbjct: 66 VIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKAN 120
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/56 (41%), Positives = 34/56 (60%), Gaps = 3/56 (5%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTT--EMGYIPSSYVQPLN 113
VIA+ Y P++ L F KG+ L +L+ S GEWW A + T + G+IP ++V N
Sbjct: 66 VIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKAN 120
>gi|115298672 neutrophil cytosolic factor 1 [Homo sapiens]
Length = 390
Score = 42.0 bits (97), Expect = 0.003
Identities = 18/57 (31%), Positives = 34/57 (59%)
Query: 62 AIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNST 118
AI +Y T+ + + S GD + V++ S WW+ + G+IP+S+++PL+ + T
Sbjct: 163 AIANYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDET 219
Score = 32.3 bits (72), Expect = 2.2
Identities = 16/62 (25%), Positives = 26/62 (41%)
Query: 49 DNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSY 108
++P P + +AIK Y + +G+ + V+ WW GY PS Y
Sbjct: 220 EDPEPNYAGEPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMY 279
Query: 109 VQ 110
+Q
Sbjct: 280 LQ 281
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/54 (35%), Positives = 28/54 (51%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLN 113
V A+ D+ P L F +GD ++V+D S WW + G P +YV P+N
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 214
Score = 32.3 bits (72), Expect = 2.2
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 59 EVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWY-AHNTTEMGYIPSSYVQ 110
E IA D+ T L F +GD L VL+ + WY A + G+IP +Y++
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTS-GGEWWYAHNTTEMGYIPSSYVQPLN 113
+A+ D+ + TL +KG+ L VL + GEW A G++PS+Y+ P+N
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 120
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 1/54 (1%)
Query: 61 IAIKDYCPTNFTTLKFSKGDHLYVLDTS-GGEWWYAHNTTEMGYIPSSYVQPLN 113
+A+ D+ + TL +KG+ L VL + GEW A G++PS+Y+ P+N
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN 139
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 41.2 bits (95), Expect = 0.005
Identities = 19/54 (35%), Positives = 28/54 (51%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLN 113
V A+ D+ P L F +GD ++V+D S WW + G P +YV P+N
Sbjct: 120 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVN 173
Score = 32.3 bits (72), Expect = 2.2
Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 59 EVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWY-AHNTTEMGYIPSSYVQ 110
E IA D+ T L F +GD L VL+ + WY A + G+IP +Y++
Sbjct: 2 EAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 41.2 bits (95), Expect = 0.005
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 6/73 (8%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEM-GYIPSSYVQPLNYRNST 118
VIA DY L K + L++LD S WW N GY+PS+YV+ R ++
Sbjct: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRNAANRTGYVPSNYVE----RKNS 61
Query: 119 LSDSGMIDNLPDS 131
L ++ NL D+
Sbjct: 62 LKKGSLVKNLKDT 74
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 41.2 bits (95), Expect = 0.005
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 6/73 (8%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEM-GYIPSSYVQPLNYRNST 118
VIA DY L K + L++LD S WW N GY+PS+YV+ R ++
Sbjct: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRNAANRTGYVPSNYVE----RKNS 61
Query: 119 LSDSGMIDNLPDS 131
L ++ NL D+
Sbjct: 62 LKKGSLVKNLKDT 74
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 41.2 bits (95), Expect = 0.005
Identities = 25/73 (34%), Positives = 36/73 (49%), Gaps = 6/73 (8%)
Query: 60 VIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEM-GYIPSSYVQPLNYRNST 118
VIA DY L K + L++LD S WW N GY+PS+YV+ R ++
Sbjct: 7 VIAKWDYTAQQDQELDIKKNERLWLLDDSK-TWWRVRNAANRTGYVPSNYVE----RKNS 61
Query: 119 LSDSGMIDNLPDS 131
L ++ NL D+
Sbjct: 62 LKKGSLVKNLKDT 74
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,609,486
Number of Sequences: 37866
Number of extensions: 1736650
Number of successful extensions: 4702
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86
Number of HSP's successfully gapped in prelim test: 91
Number of HSP's that attempted gapping in prelim test: 4495
Number of HSP's gapped (non-prelim): 290
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.