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Search of human proteins with 7657544
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7657544 sodium channel, voltage gated, type VIII, alpha
[Homo sapiens]
(1980 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 3970 0.0
gi|93141214 sodium channel, voltage-gated, type II, alpha isofor... 2995 0.0
gi|93141212 sodium channel, voltage-gated, type II, alpha isofor... 2993 0.0
gi|93141210 sodium channel, voltage-gated, type II, alpha isofor... 2993 0.0
gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo ... 2969 0.0
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 2903 0.0
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 2845 0.0
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 2845 0.0
gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo s... 2752 0.0
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 2352 0.0
gi|30089970 voltage-gated sodium channel type V alpha isoform b ... 2335 0.0
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 2335 0.0
gi|150417967 voltage-gated sodium channel type V alpha isoform c... 2333 0.0
gi|150417969 voltage-gated sodium channel type V alpha isoform d... 2288 0.0
gi|237512980 voltage-gated sodium channel type V alpha isoform e... 2265 0.0
gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo ... 2060 0.0
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 1803 0.0
gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo... 1281 0.0
gi|111378393 sodium channel, voltage-gated, type VII, alpha [Hom... 1266 0.0
gi|239748090 PREDICTED: similar to sodium channel, voltage-gated... 984 0.0
gi|192807298 calcium channel, voltage-dependent, L type, alpha 1... 412 e-114
gi|192807300 calcium channel, voltage-dependent, L type, alpha 1... 407 e-113
gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D ... 407 e-113
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 330 8e-90
gi|193788548 calcium channel, voltage-dependent, L type, alpha 1... 327 7e-89
gi|193788534 calcium channel, voltage-dependent, L type, alpha 1... 327 7e-89
gi|193788538 calcium channel, voltage-dependent, L type, alpha 1... 327 9e-89
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 326 2e-88
gi|193788532 calcium channel, voltage-dependent, L type, alpha 1... 325 2e-88
gi|193788544 calcium channel, voltage-dependent, L type, alpha 1... 325 3e-88
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 3970 bits (10296), Expect = 0.0
Identities = 1980/1980 (100%), Positives = 1980/1980 (100%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE
Sbjct: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL
Sbjct: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR
Sbjct: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGF 300
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGF
Sbjct: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGF 300
Query: 301 DWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAF 360
DWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAF
Sbjct: 301 DWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAF 360
Query: 361 LALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420
LALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA
Sbjct: 361 LALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420
Query: 421 TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEI 480
TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEI
Sbjct: 421 TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEI 480
Query: 481 SKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKF 540
SKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKF
Sbjct: 481 SKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKF 540
Query: 541 SIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDS 600
SIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDS
Sbjct: 541 SIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDS 600
Query: 601 LFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG 660
LFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG
Sbjct: 601 LFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG 660
Query: 661 GRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCP 720
GRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCP
Sbjct: 661 GRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCP 720
Query: 721 PCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ 780
PCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ
Sbjct: 721 PCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQ 780
Query: 781 FEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGL 840
FEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGL
Sbjct: 781 FEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGL 840
Query: 841 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 900
SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS
Sbjct: 841 SVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKS 900
Query: 901 YKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMV 960
YKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMV
Sbjct: 901 YKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMV 960
Query: 961 MVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQ 1020
MVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQ
Sbjct: 961 MVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQ 1020
Query: 1021 AHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIID 1080
AHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIID
Sbjct: 1021 AHFKQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIID 1080
Query: 1081 EDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIK 1140
EDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIK
Sbjct: 1081 EDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIK 1140
Query: 1141 PEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWF 1200
PEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWF
Sbjct: 1141 PEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWF 1200
Query: 1201 ETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFF 1260
ETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFF
Sbjct: 1201 ETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFF 1260
Query: 1261 TNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1320
TNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL
Sbjct: 1261 TNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNAL 1320
Query: 1321 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLM 1380
VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLM
Sbjct: 1321 VGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLM 1380
Query: 1381 EGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYM 1440
EGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYM
Sbjct: 1381 EGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYM 1440
Query: 1441 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1500
YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP
Sbjct: 1441 YIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP 1500
Query: 1501 QKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLV 1560
QKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLV
Sbjct: 1501 QKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLV 1560
Query: 1561 FVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIR 1620
FVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIR
Sbjct: 1561 FVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIR 1620
Query: 1621 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEA 1680
LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEA
Sbjct: 1621 LARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEA 1680
Query: 1681 GIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPS 1740
GIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPS
Sbjct: 1681 GIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPS 1740
Query: 1741 VGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDAT 1800
VGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDAT
Sbjct: 1741 VGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDAT 1800
Query: 1801 QFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSG 1860
QFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSG
Sbjct: 1801 QFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSG 1860
Query: 1861 ELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKT 1920
ELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKT
Sbjct: 1861 ELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKT 1920
Query: 1921 TSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC 1980
TSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC
Sbjct: 1921 TSNKLENGGTHREKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESKC 1980
>gi|93141214 sodium channel, voltage-gated, type II, alpha isoform 2
[Homo sapiens]
Length = 2005
Score = 2995 bits (7764), Expect = 0.0
Identities = 1538/2027 (75%), Positives = 1730/2027 (85%), Gaps = 71/2027 (3%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MA +L PPGPDSF+ FT ESLA IE+RIAE K K+P + +++D+++ PKPNSDLE
Sbjct: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQ---ERKDEDDENGPKPNSDLE 57
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGKSLPFIYGDIP +V+VPLED DPYY+ +KTF+VLN+GK + RFSATPALYIL+PFN
Sbjct: 58 AGKSLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNP 117
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
IR++AIKIL+HS+F+M+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILAR 177
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDF+VI AY+TEFVNLGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 237
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP-------IN----FN 289
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP IN FN
Sbjct: 238 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFN 297
Query: 290 ESYLENGTKG------FDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
S NGT F+W+EYI +K++FY + G + LLCGNSSDAGQCPEGY C+KAG
Sbjct: 298 NSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAG 357
Query: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
RNPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+
Sbjct: 358 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLI 417
Query: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQAAA A SA ++
Sbjct: 418 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASA-----ESR 472
Query: 464 EEEGEEG-GGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
+ G G G SSS SKLSSKS KE +NRRKK+KQKE S EEK D +V KSESED
Sbjct: 473 DFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESED 530
Query: 523 GMRRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
+RRK FR L +R+ ++FS +QSLLSI GS F R NS++S+FSFRG R +D G
Sbjct: 531 SIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRG--RAKDIG 588
Query: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
SEN+FADDEHST E+++ RRDSLF+P R ERR +S SQ SR+SR+ P L + K
Sbjct: 589 SENDFADDEHSTFEDNDSRRDSLFVPHRHGERR-----HSNVSQASRASRVLPILPMNGK 643
Query: 639 RNSTVDCNGVVSLIGGPGSHIG-GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDR 696
+S VDCNGVVSL+GGP + G+LLPE TT E EI+K+ S VSMD L + R
Sbjct: 644 MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
Query: 697 INSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVD 756
SI S++TNT+ EELEES++KCPPCWYKFAN LIW+C W+K+K +VNL+VMDPFVD
Sbjct: 704 AMSIASILTNTM-EELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVD 762
Query: 757 LAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEG 816
LAITICIVLNTLFMAMEH+PMT QF VL+VGNLVFTGIFTAEMFLK+IAMDPYYYFQEG
Sbjct: 763 LAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEG 822
Query: 817 WNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 876
WNIFDGFIVSLSLMEL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
Sbjct: 823 WNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 882
Query: 877 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE 936
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI+ DCELPRWHMHDFFHSFLIVFRVLCGE
Sbjct: 883 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE 942
Query: 937 WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNN 996
WIETMWDCMEVAGQ MCL VFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNN
Sbjct: 943 WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNN 1002
Query: 997 LQISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIH 1054
LQI+V R++KG+ + K K+ F+Q F KQ+ DE+KPL++L KK +CI+NHT +I
Sbjct: 1003 LQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIG 1062
Query: 1055 RNGDFQKNGNGTTSGIGSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDV 1113
++ ++ K+GNGTTSGIGSSVEKY++DE D+MSFINNP+LTV VPIAVGESDFENLNTE+
Sbjct: 1063 KDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEF 1122
Query: 1114 SSESDPEGSKDKLDDTSSSEGSTIDIKPEVE-EVPVEQPEEYLDPDACFTEGCVQRFKCC 1172
SSESD E SK+KL+ TSSSEGST+DI E E P +PEE L+P+ACFTE CV++FKCC
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
Query: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232
Q++IEEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Query: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
EYADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL ANALGYSELGAI
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
Query: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
KSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
Query: 1353 YHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATF 1412
+++C N T+ F++ VNN +EC+ L+E N T RWKNVK+NFDNVG GYL+LLQVATF
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTA-RWKNVKVNFDNVGLGYLSLLQVATF 1421
Query: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1472
KGWMDIMYAAVDSR + QPKYEDN+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKK
Sbjct: 1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Query: 1473 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLI 1532
KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LI
Sbjct: 1482 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILI 1541
Query: 1533 CLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVV 1592
CLNMVTMMVETD QS++M NILYWINLVF++ FT ECVLK+ +LR+YYFTIGWNIFDFVV
Sbjct: 1542 CLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVV 1601
Query: 1593 VILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652
VILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF
Sbjct: 1602 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
Query: 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLL 1712
NIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL
Sbjct: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLA 1721
Query: 1713 PILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV 1771
PILN PPDC DK+HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSV
Sbjct: 1722 PILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSV 1781
Query: 1772 ATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIA 1831
ATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFADAL+ PL + KPN ++LIA
Sbjct: 1782 ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIA 1841
Query: 1832 MDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLR 1891
MDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSYEPITTTL+
Sbjct: 1842 MDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLK 1901
Query: 1892 RKQEEVSAVVLQRAYRGHLAR-------------RGFIC------KKTTSNKLENGGTHR 1932
RKQEEVSA+++QRAYR +L + +G C + T +KL T
Sbjct: 1902 RKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENST-P 1960
Query: 1933 EKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
EK + TPST S PSYDSVTKPEKEK E+ + E+ + K++RESK
Sbjct: 1961 EKTDMTPSTTSPPSYDSVTKPEKEK---FEKDKSEKEDKGKDIRESK 2004
>gi|93141212 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 2993 bits (7759), Expect = 0.0
Identities = 1537/2027 (75%), Positives = 1730/2027 (85%), Gaps = 71/2027 (3%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MA +L PPGPDSF+ FT ESLA IE+RIAE K K+P + +++D+++ PKPNSDLE
Sbjct: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQ---ERKDEDDENGPKPNSDLE 57
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGKSLPFIYGDIP +V+VPLED DPYY+ +KTF+VLN+GK + RFSATPALYIL+PFN
Sbjct: 58 AGKSLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNP 117
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
IR++AIKIL+HS+F+M+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILAR 177
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDF+VI AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 237
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP-------IN----FN 289
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP IN FN
Sbjct: 238 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFN 297
Query: 290 ESYLENGTKG------FDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
S NGT F+W+EYI +K++FY + G + LLCGNSSDAGQCPEGY C+KAG
Sbjct: 298 NSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAG 357
Query: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
RNPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+
Sbjct: 358 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLI 417
Query: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQAAA A SA ++
Sbjct: 418 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASA-----ESR 472
Query: 464 EEEGEEG-GGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
+ G G G SSS SKLSSKS KE +NRRKK+KQKE S EEK D +V KSESED
Sbjct: 473 DFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESED 530
Query: 523 GMRRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
+RRK FR L +R+ ++FS +QSLLSI GS F R NS++S+FSFRG R +D G
Sbjct: 531 SIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRG--RAKDIG 588
Query: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
SEN+FADDEHST E+++ RRDSLF+P R ERR +S SQ SR+SR+ P L + K
Sbjct: 589 SENDFADDEHSTFEDNDSRRDSLFVPHRHGERR-----HSNVSQASRASRVLPILPMNGK 643
Query: 639 RNSTVDCNGVVSLIGGPGSHIG-GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDR 696
+S VDCNGVVSL+GGP + G+LLPE TT E EI+K+ S VSMD L + R
Sbjct: 644 MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
Query: 697 INSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVD 756
SI S++TNT+ EELEES++KCPPCWYKFAN LIW+C W+K+K +VNL+VMDPFVD
Sbjct: 704 AMSIASILTNTM-EELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVD 762
Query: 757 LAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEG 816
LAITICIVLNTLFMAMEH+PMT QF VL+VGNLVFTGIFTAEMFLK+IAMDPYYYFQEG
Sbjct: 763 LAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEG 822
Query: 817 WNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 876
WNIFDGFIVSLSLMEL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
Sbjct: 823 WNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 882
Query: 877 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE 936
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI+ DCELPRWHMHDFFHSFLIVFRVLCGE
Sbjct: 883 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE 942
Query: 937 WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNN 996
WIETMWDCMEVAGQ MCL VFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNN
Sbjct: 943 WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNN 1002
Query: 997 LQISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIH 1054
LQI+V R++KG+ + K K+ F+Q F KQ+ DE+KPL++L KK +CI+NHT +I
Sbjct: 1003 LQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIG 1062
Query: 1055 RNGDFQKNGNGTTSGIGSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDV 1113
++ ++ K+GNGTTSGIGSSVEKY++DE D+MSFINNP+LTV VPIAVGESDFENLNTE+
Sbjct: 1063 KDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEF 1122
Query: 1114 SSESDPEGSKDKLDDTSSSEGSTIDIKPEVE-EVPVEQPEEYLDPDACFTEGCVQRFKCC 1172
SSESD E SK+KL+ TSSSEGST+DI E E P +PEE L+P+ACFTE CV++FKCC
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
Query: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232
Q++IEEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Query: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
EYADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL ANALGYSELGAI
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
Query: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
KSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
Query: 1353 YHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATF 1412
+++C N T+ F++ VNN +EC+ L+E N T RWKNVK+NFDNVG GYL+LLQVATF
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTA-RWKNVKVNFDNVGLGYLSLLQVATF 1421
Query: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1472
KGWMDIMYAAVDSR + QPKYEDN+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKK
Sbjct: 1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Query: 1473 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLI 1532
KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LI
Sbjct: 1482 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILI 1541
Query: 1533 CLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVV 1592
CLNMVTMMVETD QS++M NILYWINLVF++ FT ECVLK+ +LR+YYFTIGWNIFDFVV
Sbjct: 1542 CLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVV 1601
Query: 1593 VILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652
VILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF
Sbjct: 1602 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
Query: 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLL 1712
NIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL
Sbjct: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLA 1721
Query: 1713 PILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV 1771
PILN PPDC DK+HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSV
Sbjct: 1722 PILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSV 1781
Query: 1772 ATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIA 1831
ATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFADAL+ PL + KPN ++LIA
Sbjct: 1782 ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIA 1841
Query: 1832 MDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLR 1891
MDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSYEPITTTL+
Sbjct: 1842 MDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLK 1901
Query: 1892 RKQEEVSAVVLQRAYRGHLAR-------------RGFIC------KKTTSNKLENGGTHR 1932
RKQEEVSA+++QRAYR +L + +G C + T +KL T
Sbjct: 1902 RKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENST-P 1960
Query: 1933 EKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
EK + TPST S PSYDSVTKPEKEK E+ + E+ + K++RESK
Sbjct: 1961 EKTDMTPSTTSPPSYDSVTKPEKEK---FEKDKSEKEDKGKDIRESK 2004
>gi|93141210 sodium channel, voltage-gated, type II, alpha isoform 1
[Homo sapiens]
Length = 2005
Score = 2993 bits (7759), Expect = 0.0
Identities = 1537/2027 (75%), Positives = 1730/2027 (85%), Gaps = 71/2027 (3%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MA +L PPGPDSF+ FT ESLA IE+RIAE K K+P + +++D+++ PKPNSDLE
Sbjct: 1 MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQ---ERKDEDDENGPKPNSDLE 57
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGKSLPFIYGDIP +V+VPLED DPYY+ +KTF+VLN+GK + RFSATPALYIL+PFN
Sbjct: 58 AGKSLPFIYGDIPPEMVSVPLEDLDPYYINKKTFIVLNKGKAISRFSATPALYILTPFNP 117
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
IR++AIKIL+HS+F+M+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 118 IRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILAR 177
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDF+VI AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 178 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 237
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP-------IN----FN 289
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP IN FN
Sbjct: 238 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEINITSFFN 297
Query: 290 ESYLENGTKG------FDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
S NGT F+W+EYI +K++FY + G + LLCGNSSDAGQCPEGY C+KAG
Sbjct: 298 NSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVKAG 357
Query: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
RNPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+
Sbjct: 358 RNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLI 417
Query: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQAAA A SA ++
Sbjct: 418 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASA-----ESR 472
Query: 464 EEEGEEG-GGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
+ G G G SSS SKLSSKS KE +NRRKK+KQKE S EEK D +V KSESED
Sbjct: 473 DFSGAGGIGVFSESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEEKND--RVRKSESED 530
Query: 523 GMRRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
+RRK FR L +R+ ++FS +QSLLSI GS F R NS++S+FSFRG R +D G
Sbjct: 531 SIRRKGFRFSLEGSRLTYEKRFSSPHQSLLSIRGSLFSPRRNSRASLFSFRG--RAKDIG 588
Query: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
SEN+FADDEHST E+++ RRDSLF+P R ERR +S SQ SR+SR+ P L + K
Sbjct: 589 SENDFADDEHSTFEDNDSRRDSLFVPHRHGERR-----HSNVSQASRASRVLPILPMNGK 643
Query: 639 RNSTVDCNGVVSLIGGPGSHIG-GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDR 696
+S VDCNGVVSL+GGP + G+LLPE TT E EI+K+ S VSMD L + R
Sbjct: 644 MHSAVDCNGVVSLVGGPSTLTSAGQLLPEGTTTETEIRKRRSSSYHVSMDLLEDPTSRQR 703
Query: 697 INSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVD 756
SI S++TNT+ EELEES++KCPPCWYKFAN LIW+C W+K+K +VNL+VMDPFVD
Sbjct: 704 AMSIASILTNTM-EELEESRQKCPPCWYKFANMCLIWDCCKPWLKVKHLVNLVVMDPFVD 762
Query: 757 LAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEG 816
LAITICIVLNTLFMAMEH+PMT QF VL+VGNLVFTGIFTAEMFLK+IAMDPYYYFQEG
Sbjct: 763 LAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMFLKIIAMDPYYYFQEG 822
Query: 817 WNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 876
WNIFDGFIVSLSLMEL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG
Sbjct: 823 WNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALG 882
Query: 877 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE 936
NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKI+ DCELPRWHMHDFFHSFLIVFRVLCGE
Sbjct: 883 NLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFHSFLIVFRVLCGE 942
Query: 937 WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNN 996
WIETMWDCMEVAGQ MCL VFMMVMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNN
Sbjct: 943 WIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNN 1002
Query: 997 LQISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIH 1054
LQI+V R++KG+ + K K+ F+Q F KQ+ DE+KPL++L KK +CI+NHT +I
Sbjct: 1003 LQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDSCISNHTTIEIG 1062
Query: 1055 RNGDFQKNGNGTTSGIGSSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDV 1113
++ ++ K+GNGTTSGIGSSVEKY++DE D+MSFINNP+LTV VPIAVGESDFENLNTE+
Sbjct: 1063 KDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEF 1122
Query: 1114 SSESDPEGSKDKLDDTSSSEGSTIDIKPEVE-EVPVEQPEEYLDPDACFTEGCVQRFKCC 1172
SSESD E SK+KL+ TSSSEGST+DI E E P +PEE L+P+ACFTE CV++FKCC
Sbjct: 1123 SSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKFKCC 1182
Query: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232
Q++IEEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+L
Sbjct: 1183 QISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTML 1242
Query: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
EYADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL ANALGYSELGAI
Sbjct: 1243 EYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAI 1302
Query: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
KSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK
Sbjct: 1303 KSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1362
Query: 1353 YHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATF 1412
+++C N T+ F++ VNN +EC+ L+E N T RWKNVK+NFDNVG GYL+LLQVATF
Sbjct: 1363 FYHCINYTTGEMFDVSVVNNYSECKALIESNQTA-RWKNVKVNFDNVGLGYLSLLQVATF 1421
Query: 1413 KGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1472
KGWMDIMYAAVDSR + QPKYEDN+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKK
Sbjct: 1422 KGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1481
Query: 1473 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLI 1532
KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LI
Sbjct: 1482 KFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILI 1541
Query: 1533 CLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVV 1592
CLNMVTMMVETD QS++M NILYWINLVF++ FT ECVLK+ +LR+YYFTIGWNIFDFVV
Sbjct: 1542 CLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVV 1601
Query: 1593 VILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652
VILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF
Sbjct: 1602 VILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1661
Query: 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLL 1712
NIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL
Sbjct: 1662 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLA 1721
Query: 1713 PILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSV 1771
PILN PPDC DK+HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSV
Sbjct: 1722 PILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSV 1781
Query: 1772 ATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIA 1831
ATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFADAL+ PL + KPN ++LIA
Sbjct: 1782 ATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIA 1841
Query: 1832 MDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLR 1891
MDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSYEPITTTL+
Sbjct: 1842 MDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYEPITTTLK 1901
Query: 1892 RKQEEVSAVVLQRAYRGHLAR-------------RGFIC------KKTTSNKLENGGTHR 1932
RKQEEVSA+++QRAYR +L + +G C + T +KL T
Sbjct: 1902 RKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTLIDKLNENST-P 1960
Query: 1933 EKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
EK + TPST S PSYDSVTKPEKEK E+ + E+ + K++RESK
Sbjct: 1961 EKTDMTPSTTSPPSYDSVTKPEKEK---FEKDKSEKEDKGKDIRESK 2004
>gi|115583677 sodium channel, voltage-gated, type I, alpha [Homo
sapiens]
Length = 1998
Score = 2969 bits (7697), Expect = 0.0
Identities = 1531/2019 (75%), Positives = 1717/2019 (85%), Gaps = 72/2019 (3%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
M +L PPGPDSF FT ESLA IERRIAE K K P K D ++DD+++ PKPNSDLE
Sbjct: 1 MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNP-KPD---KKDDDENGPKPNSDLE 56
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGK+LPFIYGDIP +V+ PLED DPYY+ +KTF+VLN+GK +FRFSAT ALYIL+PFN
Sbjct: 57 AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNP 116
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
+R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KIIAR
Sbjct: 117 LRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIAR 176
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDF+VI AY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 177 GFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP--------------- 285
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP
Sbjct: 237 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNI 296
Query: 286 -INFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGR 344
+N+N + + FDW+ YI + Y + G L+ LLCGNSSDAGQCPEGY C+KAGR
Sbjct: 297 TVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGR 356
Query: 345 NPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVN 404
NPNYGYTSFDTFSWAFL+LFRLMTQD+WENLYQLTLRAAGKTYMIFFVLVIF+GSFYL+N
Sbjct: 357 NPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLIN 416
Query: 405 LILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIE 464
LILAVVAMAYEEQNQATLEEAEQKEAEF+ M+EQLKKQQE AQ AA AT+ SE +
Sbjct: 417 LILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATA----SEHS-- 470
Query: 465 EEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGM 524
E G SSSE SKLSSKSAKERRNRRKKRKQKE S GEEK D ++ KSESED +
Sbjct: 471 REPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEK-DEDEFQKSESEDSI 529
Query: 525 RRKAFR--LPDNRIG--RKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSE 580
RRK FR + NR+ +++S +QSLLSI GS F R NS++S+FSFRG R +D GSE
Sbjct: 530 RRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRG--RAKDVGSE 587
Query: 581 NEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRN 640
N+FADDEHST E++E RRDSLF+P R ERR+S SQ SRSSR+ + K +
Sbjct: 588 NDFADDEHSTFEDNESRRDSLFVPRRHGERRNS-----NLSQTSRSSRMLAVFPANGKMH 642
Query: 641 STVDCNGVVSLIGGPGSHIG--GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKDRI 697
STVDCNGVVSL+GGP G+LLPE TT E E++K+ S VSMD L ++ R
Sbjct: 643 STVDCNGVVSLVGGPSVPTSPVGQLLPEGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRA 702
Query: 698 NSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDL 757
SI S++TNT VEELEES++KCPPCWYKF+N FLIW+C PYW+K+K +VNL+VMDPFVDL
Sbjct: 703 MSIASILTNT-VEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDL 761
Query: 758 AITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGW 817
AITICIVLNTLFMAMEH+PMT F +VL VGNLVFTGIFTAEMFLK+IAMDPYYYFQEGW
Sbjct: 762 AITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGW 821
Query: 818 NIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN 877
NIFDGFIV+LSL+EL LA+VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN
Sbjct: 822 NIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGN 881
Query: 878 LTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEW 937
LTLVLAIIVFIFAVVGMQLFGKSYK+CVCKI DC+LPRWHM+DFFHSFLIVFRVLCGEW
Sbjct: 882 LTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEW 941
Query: 938 IETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNL 997
IETMWDCMEVAGQAMCL VFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDD EMNNL
Sbjct: 942 IETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNL 1001
Query: 998 QISVIRIKKGVAWTKLKVHAFMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIHR 1055
QI+V R+ KGVA+ K K++ F+Q F KQ+ DE+KPLD+L KK +C++NHT A+I +
Sbjct: 1002 QIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHT-AEIGK 1060
Query: 1056 NGDFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTED 1112
+ D+ K+ NGTTSGIG SSVEKYIIDE D+MSFINNP+LTV VPIAVGESDFENLNTED
Sbjct: 1061 DLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTED 1120
Query: 1113 VSSESDPEGSKDKLDDTSSS-EGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKC 1171
SSESD E SK+KL+++SSS EGST+DI VEE PV +PEE L+P+ACFTEGCVQRFKC
Sbjct: 1121 FSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKC 1180
Query: 1172 CQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTI 1231
CQ+N+EEG GK WW LR+TCF IVEHNWFETFI+FMILLSSGALAFEDIYI+QRKTI+T+
Sbjct: 1181 CQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTM 1240
Query: 1232 LEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGA 1291
LEYADKVFTYIFILEMLLKW AYG+ +FTNAWCWLDFLIV VSLVSL ANALGYSELGA
Sbjct: 1241 LEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGA 1300
Query: 1292 IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1351
IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAG
Sbjct: 1301 IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1360
Query: 1352 KYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT 1411
K+++C N T+ RF+IEDVNN T+C KL+E N T RWKNVK+NFDNVG GYL+LLQVAT
Sbjct: 1361 KFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETA-RWKNVKVNFDNVGFGYLSLLQVAT 1419
Query: 1412 FKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1471
FKGWMDIMYAAVDSR + QPKYE+++YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQK
Sbjct: 1420 FKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1479
Query: 1472 KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMML 1531
KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+L
Sbjct: 1480 KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMIL 1539
Query: 1532 ICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFV 1591
ICLNMVTMMVETD QS+ + IL INLVF++ FT ECVLK+ +LRHYYFTIGWNIFDFV
Sbjct: 1540 ICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFV 1599
Query: 1592 VVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1651
VVILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL
Sbjct: 1600 VVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1659
Query: 1652 FNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1711
FNIGLLLFLVMFI++IFGMSNFAYVK E GIDDMFNFETFGNSMICLFQITTSAGWDGLL
Sbjct: 1660 FNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1719
Query: 1712 LPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFS 1770
PILN +PPDC +K +PGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFS
Sbjct: 1720 APILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFS 1779
Query: 1771 VATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELI 1830
VATEESA+PLSEDDFE FYE+WEKFDPDATQF+E+ KL+ FA ALE PL +P+PN ++LI
Sbjct: 1780 VATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLI 1839
Query: 1831 AMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTL 1890
AMDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QMEERF+ASNPSKVSY+PITTTL
Sbjct: 1840 AMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTL 1899
Query: 1891 RRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTHR 1932
+RKQEEVSAV++QRAYR HL +R T NK + N +
Sbjct: 1900 KRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSIT 1959
Query: 1933 EKKESTPSTASLP-SYDSVTKPEKEKQQRAEEGRRERAK 1970
EK + T STA+ P SYD VTKP EK + +EG+ E+AK
Sbjct: 1960 EKTDLTMSTAACPPSYDRVTKPIVEKHE--QEGKDEKAK 1996
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 2903 bits (7525), Expect = 0.0
Identities = 1498/2028 (73%), Positives = 1697/2028 (83%), Gaps = 78/2028 (3%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MA LL PPGP+SF+ FT ESLA IE+R AE K KKP K +++D+++KPKPNSDLE
Sbjct: 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKK----EQDNDDENKPKPNSDLE 56
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGK+LPFIYGDIP +V+ PLED DPYY+ +KTF+V+N+GK +FRFSAT ALYIL+P N
Sbjct: 57 AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNP 116
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
+R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILAR 176
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDFSVI+MAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPIN-----------FN 289
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP + FN
Sbjct: 237 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFN 296
Query: 290 ESYLENGT------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
+ NGT F+W++YI + ++FY + G +PLLCGN SDAGQCPEGY C+KAG
Sbjct: 297 GTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAG 356
Query: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
RNPNYGYTSFDTFSWAFL+LFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF+GSFYLV
Sbjct: 357 RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLV 416
Query: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQA A A++A
Sbjct: 417 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR------ 470
Query: 464 EEEGEEGGGSP-RSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
+ G G G SSSE SKLSSKSAKE RNRRKKR+Q+E EG KG+ + KSESED
Sbjct: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED 530
Query: 523 GMRRKAF--RLPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
++R +F + NR+ +KF +QSLLSI GS F R NSK+SIFSFRG R +D G
Sbjct: 531 SVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRG--RAKDVG 588
Query: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
SEN+FADDEHST E+SE RRDSLF+P R ERR+S SQ S SSR+ P L + K
Sbjct: 589 SENDFADDEHSTFEDSESRRDSLFVPHRHGERRNS-----NVSQASMSSRMVPGLPANGK 643
Query: 639 RNSTVDCNGVVSLIGGPGSHIG--GRLLPEATT-EVEIKKKGPGSLLVSMDQLASYGRKD 695
+STVDCNGVVSL+GGP + G+L PE TT E E++K+ S +SM+ L +
Sbjct: 644 MHSTVDCNGVVSLVGGPSALTSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQ 703
Query: 696 RINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFV 755
R SI S++TNT+ EELEES++KCPPCWY+FAN FLIW+C W+K+K +VNLIVMDPFV
Sbjct: 704 RAVSIASILTNTM-EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFV 762
Query: 756 DLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQE 815
DLAITICIVLNTLFMAMEH+PMT QF VL VGNLVFTGIFTAEM LK+IAMDPYYYFQE
Sbjct: 763 DLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQE 822
Query: 816 GWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 875
GWNIFDG IVSLSLMEL L++VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL
Sbjct: 823 GWNIFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGAL 882
Query: 876 GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCG 935
GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCG
Sbjct: 883 GNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCG 942
Query: 936 EWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMN 995
EWIETMWDCMEVAGQ MCLIVFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMN
Sbjct: 943 EWIETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMN 1002
Query: 996 NLQISVIRIKKGVAWTKLKVH-AFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIH 1054
NLQI+V R++KG+ + K K+ F +A F++ + E+ +++ +C++N+TG +I
Sbjct: 1003 NLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKI----DSCMSNNTGIEIS 1058
Query: 1055 RNGDFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTE 1111
+ ++ ++GNGTTSG+G SSVEKY+IDE D+MSFINNP+LTV VPIAVGESDFENLNTE
Sbjct: 1059 KELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTE 1118
Query: 1112 DVSSESDPEGSKDKLDDTSSSEGSTIDIK-PEVEEVPVEQPEEYLDPDACFTEGCVQRFK 1170
+ SSES+ E SK+KL+ TSSSEGST+D+ P E +PEE L P+ACFTEGC+++F
Sbjct: 1119 EFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFP 1178
Query: 1171 CCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRT 1230
CQV+ EEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T
Sbjct: 1179 FCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKT 1238
Query: 1231 ILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELG 1290
+LEYADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL+ANALGYSELG
Sbjct: 1239 MLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELG 1298
Query: 1291 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1350
AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA
Sbjct: 1299 AIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1358
Query: 1351 GKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVA 1410
GK+++C N T+ F+I DVNN ++C+ L + RWKNVK+NFDNVGAGYLALLQVA
Sbjct: 1359 GKFYHCVNMTTGNMFDISDVNNLSDCQAL----GKQARWKNVKVNFDNVGAGYLALLQVA 1414
Query: 1411 TFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1470
TFKGWMDIMYAAVDSR QP YE+N+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQ
Sbjct: 1415 TFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1474
Query: 1471 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMM 1530
KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+
Sbjct: 1475 KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMI 1534
Query: 1531 LICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDF 1590
LICLNMVTMMVETD Q K M +L INLVF++ FT E VLK+ +LRHYYFTIGWNIFDF
Sbjct: 1535 LICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDF 1594
Query: 1591 VVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1650
VVVILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA
Sbjct: 1595 VVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPA 1654
Query: 1651 LFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGL 1710
LFNIGLLLFLVMFI++IFGMSNFAYVK EAGIDDMFNFETFGNSMICLFQITTSAGWDGL
Sbjct: 1655 LFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGL 1714
Query: 1711 LLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1769
L PILN PPDC D HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENF
Sbjct: 1715 LAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENF 1774
Query: 1770 SVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIEL 1829
SVATEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++L
Sbjct: 1775 SVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQL 1834
Query: 1830 IAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTT 1889
IAMDLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QME+RF+ASNPSKVSYEPITTT
Sbjct: 1835 IAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTT 1894
Query: 1890 LRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTH 1931
L+RKQEEVSA ++QR +R +L ++ + NK NG +
Sbjct: 1895 LKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNST 1954
Query: 1932 REKKESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
EK + + ST S PSYDSVTKP+KEK E+ + E+ + KEVRE++
Sbjct: 1955 PEKTDGSSSTTSPPSYDSVTKPDKEK---FEKDKPEKESKGKEVRENQ 1999
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 2845 bits (7375), Expect = 0.0
Identities = 1473/2025 (72%), Positives = 1666/2025 (82%), Gaps = 121/2025 (5%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MA LL PPGP+SF+ FT ESLA IE+R AE K KKP K +++D+++KPKPNSDLE
Sbjct: 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKK----EQDNDDENKPKPNSDLE 56
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGK+LPFIYGDIP +V+ PLED DPYY+ +KTF+V+N+GK +FRFSAT ALYIL+P N
Sbjct: 57 AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNP 116
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
+R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILAR 176
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDFSVI+MAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVSLGNVSALRTFRVLRALKTISVIPGLKTI 236
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPIN-----------FN 289
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP + FN
Sbjct: 237 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFN 296
Query: 290 ESYLENGT------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
+ NGT F+W++YI + ++FY + G +PLLCGN SDAGQCPEGY C+KAG
Sbjct: 297 GTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAG 356
Query: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
RNPNYGYTSFDTFSWAFL+LFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF+GSFYLV
Sbjct: 357 RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLV 416
Query: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQA A A++A
Sbjct: 417 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR------ 470
Query: 464 EEEGEEGGGSP-RSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
+ G G G SSSE SKLSSKSAKE RNRRKKR+Q+E EG KG+ + KSESED
Sbjct: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED 530
Query: 523 GMRRKAF--RLPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
++R +F + NR+ +KF +QSLLSI GS F R NSK+SIFSFRG R +D G
Sbjct: 531 SVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRG--RAKDVG 588
Query: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
SEN+FADDEHST E+SE RRDSLF+P R ERR+S
Sbjct: 589 SENDFADDEHSTFEDSESRRDSLFVPHRHGERRNS------------------------- 623
Query: 639 RNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRIN 698
NG TTE E++K+ S +SM+ L + R
Sbjct: 624 -------NGT-------------------TTETEVRKRRLSSYQISMEMLEDSSGRQRAV 657
Query: 699 SIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLA 758
SI S++TNT+ EELEES++KCPPCWY+FAN FLIW+C W+K+K +VNLIVMDPFVDLA
Sbjct: 658 SIASILTNTM-EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLA 716
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
ITICIVLNTLFMAMEH+PMT QF VL VGNLVFTGIFTAEM LK+IAMDPYYYFQEGWN
Sbjct: 717 ITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWN 776
Query: 819 IFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 878
IFDG IVSLSLMEL L++VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL
Sbjct: 777 IFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 836
Query: 879 TLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWI 938
TLVLAIIVFIFAVVGMQLFGKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCGEWI
Sbjct: 837 TLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWI 896
Query: 939 ETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQ 998
ETMWDCMEVAGQ MCLIVFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNNLQ
Sbjct: 897 ETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQ 956
Query: 999 ISVIRIKKGVAWTKLKVH-AFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNG 1057
I+V R++KG+ + K K+ F +A F++ + E+ +++ +C++N+TG +I +
Sbjct: 957 IAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKI----DSCMSNNTGIEISKEL 1012
Query: 1058 DFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVS 1114
++ ++GNGTTSG+G SSVEKY+IDE D+MSFINNP+LTV VPIAVGESDFENLNTE+ S
Sbjct: 1013 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1072
Query: 1115 SESDPEGSKDKLDDTSSSEGSTIDIK-PEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQ 1173
SES+ E SK+KL+ TSSSEGST+D+ P E +PEE L P+ACFTEGC+++F CQ
Sbjct: 1073 SESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQ 1132
Query: 1174 VNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILE 1233
V+ EEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+LE
Sbjct: 1133 VSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLE 1192
Query: 1234 YADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIK 1293
YADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL+ANALGYSELGAIK
Sbjct: 1193 YADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIK 1252
Query: 1294 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY 1353
SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+
Sbjct: 1253 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1312
Query: 1354 HYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFK 1413
++C N T+ F+I DVNN ++C+ L + RWKNVK+NFDNVGAGYLALLQVATFK
Sbjct: 1313 YHCVNMTTGNMFDISDVNNLSDCQAL----GKQARWKNVKVNFDNVGAGYLALLQVATFK 1368
Query: 1414 GWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1473
GWMDIMYAAVDSR QP YE+N+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1369 GWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1428
Query: 1474 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLIC 1533
FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LIC
Sbjct: 1429 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1488
Query: 1534 LNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVV 1593
LNMVTMMVETD Q K M +L INLVF++ FT E VLK+ +LRHYYFTIGWNIFDFVVV
Sbjct: 1489 LNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVV 1548
Query: 1594 ILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1653
ILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN
Sbjct: 1549 ILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1608
Query: 1654 IGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLP 1713
IGLLLFLVMFI++IFGMSNFAYVK EAGIDDMFNFETFGNSMICLFQITTSAGWDGLL P
Sbjct: 1609 IGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1668
Query: 1714 ILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVA 1772
ILN PPDC D HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSVA
Sbjct: 1669 ILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1728
Query: 1773 TEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAM 1832
TEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++LIAM
Sbjct: 1729 TEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAM 1788
Query: 1833 DLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRR 1892
DLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QME+RF+ASNPSKVSYEPITTTL+R
Sbjct: 1789 DLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKR 1848
Query: 1893 KQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTHREK 1934
KQEEVSA ++QR +R +L ++ + NK NG + EK
Sbjct: 1849 KQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEK 1908
Query: 1935 KESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
+ + ST S PSYDSVTKP+KEK E+ + E+ + KEVRE++
Sbjct: 1909 TDGSSSTTSPPSYDSVTKPDKEK---FEKDKPEKESKGKEVRENQ 1950
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 2845 bits (7375), Expect = 0.0
Identities = 1473/2025 (72%), Positives = 1666/2025 (82%), Gaps = 121/2025 (5%)
Query: 1 MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLE 60
MA LL PPGP+SF+ FT ESLA IE+R AE K KKP K +++D+++KPKPNSDLE
Sbjct: 1 MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKK----EQDNDDENKPKPNSDLE 56
Query: 61 AGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNL 120
AGK+LPFIYGDIP +V+ PLED DPYY+ +KTF+V+N+GK +FRFSAT ALYIL+P N
Sbjct: 57 AGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVMNKGKAIFRFSATSALYILTPLNP 116
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIAR 180
+R+IAIKIL+HS+FSM+IMCTILTNCVFMT SNPPDW+KNVEYTFTGIYTFESL+KI+AR
Sbjct: 117 VRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILAR 176
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
GFC++ FTFLRDPWNWLDFSVI+MAY+TEFV+LGNVSALRTFRVLRALKTISVIPGLKTI
Sbjct: 177 GFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTI 236
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPIN-----------FN 289
VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC+ WP + FN
Sbjct: 237 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAFETNTTSYFN 296
Query: 290 ESYLENGT------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAG 343
+ NGT F+W++YI + ++FY + G +PLLCGN SDAGQCPEGY C+KAG
Sbjct: 297 GTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQCPEGYICVKAG 356
Query: 344 RNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLV 403
RNPNYGYTSFDTFSWAFL+LFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIF+GSFYLV
Sbjct: 357 RNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLV 416
Query: 404 NLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAI 463
NLILAVVAMAYEEQNQATLEEAEQKEAEF+ MLEQLKKQQEEAQA A A++A
Sbjct: 417 NLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASR------ 470
Query: 464 EEEGEEGGGSP-RSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESED 522
+ G G G SSSE SKLSSKSAKE RNRRKKR+Q+E EG KG+ + KSESED
Sbjct: 471 DFSGIGGLGELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESED 530
Query: 523 GMRRKAF--RLPDNRI--GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPG 578
++R +F + NR+ +KF +QSLLSI GS F R NSK+SIFSFRG R +D G
Sbjct: 531 SVKRSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRG--RAKDVG 588
Query: 579 SENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVK 638
SEN+FADDEHST E+SE RRDSLF+P R ERR+S
Sbjct: 589 SENDFADDEHSTFEDSESRRDSLFVPHRHGERRNS------------------------- 623
Query: 639 RNSTVDCNGVVSLIGGPGSHIGGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRIN 698
NG TTE E++K+ S +SM+ L + R
Sbjct: 624 -------NGT-------------------TTETEVRKRRLSSYQISMEMLEDSSGRQRAV 657
Query: 699 SIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLA 758
SI S++TNT+ EELEES++KCPPCWY+FAN FLIW+C W+K+K +VNLIVMDPFVDLA
Sbjct: 658 SIASILTNTM-EELEESRQKCPPCWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLA 716
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
ITICIVLNTLFMAMEH+PMT QF VL VGNLVFTGIFTAEM LK+IAMDPYYYFQEGWN
Sbjct: 717 ITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWN 776
Query: 819 IFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 878
IFDG IVSLSLMEL L++VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL
Sbjct: 777 IFDGIIVSLSLMELGLSNVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 836
Query: 879 TLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWI 938
TLVLAIIVFIFAVVGMQLFGKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCGEWI
Sbjct: 837 TLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWI 896
Query: 939 ETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQ 998
ETMWDCMEVAGQ MCLIVFM+VMVIGNLVVLNLFLALLLSSFS+DNLAATDDD EMNNLQ
Sbjct: 897 ETMWDCMEVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQ 956
Query: 999 ISVIRIKKGVAWTKLKVH-AFMQAHFKQREADEVKPLDELYEKKANCIANHTGADIHRNG 1057
I+V R++KG+ + K K+ F +A F++ + E+ +++ +C++N+TG +I +
Sbjct: 957 IAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNKI----DSCMSNNTGIEISKEL 1012
Query: 1058 DFQKNGNGTTSGIG--SSVEKYIIDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVS 1114
++ ++GNGTTSG+G SSVEKY+IDE D+MSFINNP+LTV VPIAVGESDFENLNTE+ S
Sbjct: 1013 NYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFS 1072
Query: 1115 SESDPEGSKDKLDDTSSSEGSTIDIK-PEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQ 1173
SES+ E SK+KL+ TSSSEGST+D+ P E +PEE L P+ACFTEGC+++F CQ
Sbjct: 1073 SESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGCIKKFPFCQ 1132
Query: 1174 VNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILE 1233
V+ EEG GK WW LRKTC+ IVEHNWFETFI+FMILLSSGALAFEDIYIEQRKTI+T+LE
Sbjct: 1133 VSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLE 1192
Query: 1234 YADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIK 1293
YADKVFTYIFILEMLLKW AYGF +FTNAWCWLDFLIV VSLVSL+ANALGYSELGAIK
Sbjct: 1193 YADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALGYSELGAIK 1252
Query: 1294 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY 1353
SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+
Sbjct: 1253 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1312
Query: 1354 HYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFK 1413
++C N T+ F+I DVNN ++C+ L + RWKNVK+NFDNVGAGYLALLQVATFK
Sbjct: 1313 YHCVNMTTGNMFDISDVNNLSDCQAL----GKQARWKNVKVNFDNVGAGYLALLQVATFK 1368
Query: 1414 GWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1473
GWMDIMYAAVDSR QP YE+N+YMY+YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK
Sbjct: 1369 GWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1428
Query: 1474 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLIC 1533
FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NK QG+VFDFVT+Q FDI IM+LIC
Sbjct: 1429 FGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1488
Query: 1534 LNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVV 1593
LNMVTMMVETD Q K M +L INLVF++ FT E VLK+ +LRHYYFTIGWNIFDFVVV
Sbjct: 1489 LNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTIGWNIFDFVVV 1548
Query: 1594 ILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1653
ILSIVGMFLA++IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN
Sbjct: 1549 ILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFN 1608
Query: 1654 IGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLP 1713
IGLLLFLVMFI++IFGMSNFAYVK EAGIDDMFNFETFGNSMICLFQITTSAGWDGLL P
Sbjct: 1609 IGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1668
Query: 1714 ILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVA 1772
ILN PPDC D HPGS KGDCGNPSVGIFFFVSYIIISFL+VVNMYIA+ILENFSVA
Sbjct: 1669 ILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1728
Query: 1773 TEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAM 1832
TEESA+PLSEDDFE FYE+WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++LIAM
Sbjct: 1729 TEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAM 1788
Query: 1833 DLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRR 1892
DLPMVSGDRIHCLDILFAFTKRVLG+SGE+D LR QME+RF+ASNPSKVSYEPITTTL+R
Sbjct: 1789 DLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSKVSYEPITTTLKR 1848
Query: 1893 KQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE------------------NGGTHREK 1934
KQEEVSA ++QR +R +L ++ + NK NG + EK
Sbjct: 1849 KQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMIIDKLNGNSTPEK 1908
Query: 1935 KESTPSTASLPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVRESK 1979
+ + ST S PSYDSVTKP+KEK E+ + E+ + KEVRE++
Sbjct: 1909 TDGSSSTTSPPSYDSVTKPDKEK---FEKDKPEKESKGKEVRENQ 1950
>gi|4506813 sodium channel, voltage-gated, type IX, alpha [Homo
sapiens]
Length = 1977
Score = 2752 bits (7134), Expect = 0.0
Identities = 1424/2005 (71%), Positives = 1640/2005 (81%), Gaps = 61/2005 (3%)
Query: 5 LLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKS 64
+L PPGP SF FT +SLA IE+RIAE K K+P + ++DD++ PKP+SDLEAGK
Sbjct: 3 MLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKE----EKKDDDEEAPKPSSDLEAGKQ 58
Query: 65 LPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRI 124
LPFIYGDIP G+V+ PLED DPYY +KTF+VLN+GKT+FRF+ATPALY+LSPF+ +RRI
Sbjct: 59 LPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRI 118
Query: 125 AIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCI 184
+IKIL+HS+FSM+IMCTILTNC+FMT +NPPDW+KNVEYTFTGIYTFESLVKI+ARGFC+
Sbjct: 119 SIKILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCV 178
Query: 185 DGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244
FTFLRDPWNWLDF VI+ AY+TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL
Sbjct: 179 GEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 238
Query: 245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEE 304
IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNL++KC + NE+ LE+ + EE
Sbjct: 239 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNET-LESIMNTLESEE 297
Query: 305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALF 364
+ + FY + G + LLCG S+D+GQCPEGY C+K GRNP+YGYTSFDTFSWAFLALF
Sbjct: 298 --DFRKYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALF 355
Query: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEE 424
RLMTQDYWENLYQ TLRAAGKTYMIFFV+VIF+GSFYL+NLILAVVAMAYEEQNQA +EE
Sbjct: 356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEE 415
Query: 425 AEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGT-VSEDAIEEEGEEGGGSPRSSSEISKL 483
A+QKE EF+ ML++LKK+QEEA+A A A + T + I G SSSE SKL
Sbjct: 416 AKQKELEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIM-------GLSESSSETSKL 468
Query: 484 SSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGR----K 539
SSKSAKERRNRRKK+ QK+LS GEEKGD EK+ KSESED +RRK+F L R +
Sbjct: 469 SSKSAKERRNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKR 528
Query: 540 FSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRD 599
S NQS LSI GS F +R +S++S+FSF+G GR D GSE EFADDEHS ++E RR
Sbjct: 529 LSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGR--DIGSETEFADDEHSIFGDNESRRG 586
Query: 600 SLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHI 659
SLF+P R +ERRSS SQ SRS P L + K +S VDCNGVVSL+ G + +
Sbjct: 587 SLFVPHRPQERRSS-----NISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSALM 638
Query: 660 --GGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQR 717
G+LLPE TT KK+ S L+S D L + R S S++TNT VEELEES++
Sbjct: 639 LPNGQLLPEGTTNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNT-VEELEESRQ 697
Query: 718 KCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPM 777
KCPP WY+FA+ FLIW C PYWIK K+ + IVMDPFVDLAITICIVLNTLFMAMEHHPM
Sbjct: 698 KCPPWWYRFAHKFLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPM 757
Query: 778 TPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADV 837
T +F++VLA+GNLVFTGIF AEM LKLIAMDPY YFQ GWNIFD IV+LSL+EL LADV
Sbjct: 758 TEEFKNVLAIGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADV 817
Query: 838 EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF
Sbjct: 818 EGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 877
Query: 898 GKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVF 957
GKSYKECVCKIN DC LPRWHM+DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIV+
Sbjct: 878 GKSYKECVCKINDDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVY 937
Query: 958 MMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHA 1017
MMVMVIGNLVVLNLFLALLLSSFS+DNL A ++D + NNLQI+V RIKKG+ + K +
Sbjct: 938 MMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLRE 997
Query: 1018 FMQAHF--KQREADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVE 1075
F+ F K + + E++ ++L KK N I+NHT A++ + +F K + SG GSSV+
Sbjct: 998 FILKAFSKKPKISREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKD-KISGFGSSVD 1056
Query: 1076 KYII-DEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEG 1134
K+++ D D SFI+NP+LTV VPIA GESD EN+N E++SS+SD E SK +L+ +SSSE
Sbjct: 1057 KHLMEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSEC 1116
Query: 1135 STID--IKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1192
ST+D + E EE E P +P+ACFT+GCV+RF CCQVNIE G GK WW +RKTC+
Sbjct: 1117 STVDNPLPGEGEEAEAE-PMNSDEPEACFTDGCVRRFSCCQVNIESGKGKIWWNIRKTCY 1175
Query: 1193 LIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWT 1252
IVEH+WFE+FI+ MILLSSGALAFEDIYIE++KTI+ ILEYADK+FTYIFILEMLLKW
Sbjct: 1176 KIVEHSWFESFIVLMILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWI 1235
Query: 1253 AYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEG 1312
AYG+ +FTNAWCWLDFLIV VSLV+L+AN LGYS+LG IKSLRTLRALRPLRALSRFEG
Sbjct: 1236 AYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEG 1295
Query: 1313 MRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNN 1372
MRVVVNAL+GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK++ C N T RF V N
Sbjct: 1296 MRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPN 1355
Query: 1373 KTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQP 1432
++EC LM + +RWKN+K+NFDNVG GYL+LLQVATFKGW IMYAAVDS D+QP
Sbjct: 1356 RSECFALMNVSQN-VRWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQP 1414
Query: 1433 KYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAM 1492
KYE ++YMYIYFV+FIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAM
Sbjct: 1415 KYEYSLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAM 1474
Query: 1493 KKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMEN 1552
KKLGSKKPQKPIPRP NKIQG +FD VT QAFDI IM+LICLNMVTMMVE + QS+ M
Sbjct: 1475 KKLGSKKPQKPIPRPGNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTE 1534
Query: 1553 ILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVS 1612
+LYWIN+VF+I FT ECVLK+ +LRHYYFT+GWNIFDFVVVI+SIVGMFLAD+IE YFVS
Sbjct: 1535 VLYWINVVFIILFTGECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVS 1594
Query: 1613 PTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSN 1672
PTLFRVIRLARIGRILRL+KGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI++IFGMSN
Sbjct: 1595 PTLFRVIRLARIGRILRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSN 1654
Query: 1673 FAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILN-RPPDCSLDKEHPGSG 1731
FAYVK E GI+DMFNFETFGNSMICLFQITTSAGWDGLL PILN +PPDC K HPGS
Sbjct: 1655 FAYVKKEDGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSS 1714
Query: 1732 FKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEI 1791
+GDCGNPSVGIF+FVSYIIISFL+VVNMYIA+ILENFSVATEES +PLSEDDFE FYE+
Sbjct: 1715 VEGDCGNPSVGIFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEV 1774
Query: 1792 WEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAF 1851
WEKFDPDATQFIE+ KL+DFA AL+ PL + KPN ++LIAMDLPMVSGDRIHCLDILFAF
Sbjct: 1775 WEKFDPDATQFIEFSKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAF 1834
Query: 1852 TKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLA 1911
TKRVLG+SGE+D LR QMEERF+++NPSKVSYEPITTTL+RKQE+VSA V+QRAYR +
Sbjct: 1835 TKRVLGESGEMDSLRSQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRL 1894
Query: 1912 RRG-----------------FICKKTTSNKLENGGTHREKKESTPSTASLPSYDSVTKPE 1954
R+ + KK + N + EK ++T ST S PSYDSVTKP+
Sbjct: 1895 RQNVKNISSIYIKDGDRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPD 1954
Query: 1955 KEKQQRAEEGRRERAKRQKEVRESK 1979
KEK E+ R E+ + K+ +ESK
Sbjct: 1955 KEKY---EQDRTEKEDKGKDSKESK 1976
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 2352 bits (6094), Expect = 0.0
Identities = 1268/2008 (63%), Positives = 1492/2008 (74%), Gaps = 125/2008 (6%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654
SL +P R R+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 655 -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
Query: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 848 IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
Query: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
Query: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062
I++G+ + K F +QR KP + + +CIA
Sbjct: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
Query: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGS 1122
T G ++ +P V VPIAV ESD ++ ++ +S E S
Sbjct: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
Query: 1123 KDKLDDTSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEG 1179
+ + S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ +
Sbjct: 1074 SKQTPEDSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQA 1132
Query: 1180 LGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVF 1239
GK WW LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+F
Sbjct: 1133 PGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1192
Query: 1240 TYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLR 1299
TY+F+LEMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLR
Sbjct: 1193 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLR 1252
Query: 1300 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNE 1359
ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+
Sbjct: 1253 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQ 1312
Query: 1360 TS-EIRFEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMD 1417
T ++ VNNK++CE L N T E+ W VK+NFDNVGAGYLALLQVATFKGWMD
Sbjct: 1313 TEGDLPLNYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMD 1369
Query: 1418 IMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQ 1477
IMYAAVDSR +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQ
Sbjct: 1370 IMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQ 1429
Query: 1478 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMV 1537
DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMV
Sbjct: 1430 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMV 1489
Query: 1538 TMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSI 1597
TMMVETD QS + NIL INL+FV FT EC++K+ ALRHYYFT WNIFDFVVVILSI
Sbjct: 1490 TMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSI 1549
Query: 1598 VGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1657
VG L+DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLL
Sbjct: 1550 VGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1609
Query: 1658 LFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR 1717
LFLVMFI+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN
Sbjct: 1610 LFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNT 1669
Query: 1718 -PPDCSLDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEE 1775
PP C D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEE
Sbjct: 1670 GPPYC--DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEE 1727
Query: 1776 SADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLP 1835
S +PLSEDDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLP
Sbjct: 1728 STEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLP 1787
Query: 1836 MVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQE 1895
MVSGDRIHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK E
Sbjct: 1788 MVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHE 1847
Query: 1896 EVSAVVLQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE---------------- 1933
EVSA+V+QRA+R HL +R F+ ++ + L E RE
Sbjct: 1848 EVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLG 1907
Query: 1934 --KKESTPSTASLPSYDSVTKPEKEKQQ 1959
S ST+ PSYDSVT+ + Q
Sbjct: 1908 PPSSSSISSTSFPPSYDSVTRATSDNLQ 1935
>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
sapiens]
Length = 2015
Score = 2335 bits (6052), Expect = 0.0
Identities = 1277/2061 (61%), Positives = 1498/2061 (72%), Gaps = 178/2061 (8%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654
SL +P R R+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 655 -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
Query: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 848 IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
Query: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
Query: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062
I++G+ + K F +QR KP + + +CIA
Sbjct: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
Query: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFEN--------LNTEDVS 1114
T G ++ +P V VPIAV ESD ++ L TE+ S
Sbjct: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
Query: 1115 SE---------------------------SDPEGSKDKLD------------------DT 1129
S+ S+ E S + D +
Sbjct: 1074 SKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPED 1133
Query: 1130 SSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWI 1186
S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ + GK WW
Sbjct: 1134 SCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWR 1192
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+LE
Sbjct: 1193 LRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLE 1252
Query: 1247 MLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRA 1306
MLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLRA
Sbjct: 1253 MLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRA 1312
Query: 1307 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIRF 1365
LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++
Sbjct: 1313 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPL 1372
Query: 1366 EIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVD 1424
VNNK++CE L N T E+ W VK+NFDNVGAGYLALLQVATFKGWMDIMYAAVD
Sbjct: 1373 NYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVD 1429
Query: 1425 SRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1484
SR +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEE
Sbjct: 1430 SRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1489
Query: 1485 QKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETD 1544
QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVETD
Sbjct: 1490 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1549
Query: 1545 TQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLAD 1604
QS + NIL INL+FV FT EC++K+ ALRHYYFT WNIFDFVVVILSIVG L+D
Sbjct: 1550 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1609
Query: 1605 IIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1664
II+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFI
Sbjct: 1610 IIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1669
Query: 1665 FSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSL 1723
+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C
Sbjct: 1670 YSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC-- 1727
Query: 1724 DKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSE 1782
D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLSE
Sbjct: 1728 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1787
Query: 1783 DDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRI 1842
DDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLPMVSGDRI
Sbjct: 1788 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1847
Query: 1843 HCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVL 1902
HC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V+
Sbjct: 1848 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1907
Query: 1903 QRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKEST 1938
QRA+R HL +R F+ ++ + L E RE S
Sbjct: 1908 QRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSI 1967
Query: 1939 PSTASLPSYDSVTKPEKEKQQ 1959
ST+ PSYDSVT+ + Q
Sbjct: 1968 SSTSFPPSYDSVTRATSDNLQ 1988
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 2335 bits (6051), Expect = 0.0
Identities = 1277/2062 (61%), Positives = 1498/2062 (72%), Gaps = 179/2062 (8%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654
SL +P R R+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 655 -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
Query: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 848 IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
Query: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
Query: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062
I++G+ + K F +QR KP + + +CIA
Sbjct: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
Query: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFEN--------LNTEDVS 1114
T G ++ +P V VPIAV ESD ++ L TE+ S
Sbjct: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
Query: 1115 SE----------------------------SDPEGSKDKLD------------------D 1128
S+ S+ E S + D +
Sbjct: 1074 SKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPE 1133
Query: 1129 TSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWW 1185
S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ + GK WW
Sbjct: 1134 DSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1192
Query: 1186 ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFIL 1245
LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+L
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1246 EMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLR 1305
EMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLR
Sbjct: 1253 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1312
Query: 1306 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIR 1364
ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++
Sbjct: 1313 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1372
Query: 1365 FEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAV 1423
VNNK++CE L N T E+ W VK+NFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1373 LNYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1429
Query: 1424 DSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1483
DSR +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1430 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489
Query: 1484 EQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVET 1543
EQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVET
Sbjct: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1549
Query: 1544 DTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLA 1603
D QS + NIL INL+FV FT EC++K+ ALRHYYFT WNIFDFVVVILSIVG L+
Sbjct: 1550 DDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLS 1609
Query: 1604 DIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1663
DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1610 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1669
Query: 1664 IFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCS 1722
I+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C
Sbjct: 1670 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC- 1728
Query: 1723 LDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1781
D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLS
Sbjct: 1729 -DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
Query: 1782 EDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDR 1841
EDDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLPMVSGDR
Sbjct: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
Query: 1842 IHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVV 1901
IHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V
Sbjct: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
Query: 1902 LQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKES 1937
+QRA+R HL +R F+ ++ + L E RE S
Sbjct: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
Query: 1938 TPSTASLPSYDSVTKPEKEKQQ 1959
ST+ PSYDSVT+ + Q
Sbjct: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
>gi|150417967 voltage-gated sodium channel type V alpha isoform c
[Homo sapiens]
Length = 2016
Score = 2333 bits (6045), Expect = 0.0
Identities = 1274/2062 (61%), Positives = 1498/2062 (72%), Gaps = 179/2062 (8%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654
SL +P R R+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 655 -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
Query: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 848 IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
Query: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
Query: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062
I++G+ + K F +QR KP + + +CIA
Sbjct: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
Query: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFEN--------LNTEDVS 1114
T G ++ +P V VPIAV ESD ++ L TE+ S
Sbjct: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
Query: 1115 SE----------------------------SDPEGSKDKLD------------------D 1128
S+ S+ E S + D +
Sbjct: 1074 SKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPE 1133
Query: 1129 TSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWW 1185
S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ + GK WW
Sbjct: 1134 DSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1192
Query: 1186 ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFIL 1245
LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+L
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1246 EMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLR 1305
EMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLR
Sbjct: 1253 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1312
Query: 1306 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIR 1364
ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++
Sbjct: 1313 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1372
Query: 1365 FEIEDVNNKTECEKLMEGNNT-EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAV 1423
VNNK++CE L N T E+ W VK+NFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1373 LNYTIVNNKSQCESL---NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1429
Query: 1424 DSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1483
DSR +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1430 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1489
Query: 1484 EQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVET 1543
EQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVET
Sbjct: 1490 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1549
Query: 1544 DTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLA 1603
D QS + NIL INL+FV FT EC++K+ ALRHYYFT WNIFDFVVVILSIVG L+
Sbjct: 1550 DDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLS 1609
Query: 1604 DIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1663
DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1610 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1669
Query: 1664 IFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCS 1722
I+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C
Sbjct: 1670 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC- 1728
Query: 1723 LDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1781
D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLS
Sbjct: 1729 -DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1787
Query: 1782 EDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDR 1841
EDDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLPMVSGDR
Sbjct: 1788 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1847
Query: 1842 IHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVV 1901
IHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V
Sbjct: 1848 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1907
Query: 1902 LQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKES 1937
+QRA+R HL +R F+ ++ + L E RE S
Sbjct: 1908 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1967
Query: 1938 TPSTASLPSYDSVTKPEKEKQQ 1959
ST+ PSYDSVT+ + Q
Sbjct: 1968 ISSTSFPPSYDSVTRATSDNLQ 1989
>gi|150417969 voltage-gated sodium channel type V alpha isoform d
[Homo sapiens]
Length = 1998
Score = 2288 bits (5928), Expect = 0.0
Identities = 1255/2061 (60%), Positives = 1479/2061 (71%), Gaps = 195/2061 (9%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVR---NFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGG-- 654
SL +P R R+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPLR--RTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 655 -----PGSHIGGRLLPEATTEVEIKKKGPGS--LLVS----MDQLASYGRKDRINSIMSV 703
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
Query: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 848 IIVFIFAVVGMQLFGKNYSEL--RDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
Query: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
Query: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKN 1062
I++G+ + K F +QR KP + + +CIA
Sbjct: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPPPPETEKVPPT 1022
Query: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFEN--------LNTEDVS 1114
T G ++ +P V VPIAV ESD ++ L TE+ S
Sbjct: 1023 RKETRFEEG--------EQPGQGTPGDPE-PVCVPIAVAESDTDDQEEDEENSLGTEEES 1073
Query: 1115 SE----------------------------SDPEGSKDKLD------------------D 1128
S+ S+ E S + D +
Sbjct: 1074 SKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETPE 1133
Query: 1129 TSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWW 1185
S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ + GK WW
Sbjct: 1134 DSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWW 1192
Query: 1186 ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFIL 1245
LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+L
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252
Query: 1246 EMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLR 1305
EMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLR
Sbjct: 1253 EMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLR 1312
Query: 1306 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNET-SEIR 1364
ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++
Sbjct: 1313 ALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLP 1372
Query: 1365 FEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVD 1424
VNNK++CE L E+ W VK+NFDNVGAGYLALLQV
Sbjct: 1373 LNYTIVNNKSQCESL--NLTGELYWTKVKVNFDNVGAGYLALLQVY-------------- 1416
Query: 1425 SRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE 1484
+EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEE
Sbjct: 1417 ----EEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEE 1472
Query: 1485 QKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETD 1544
QKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVETD
Sbjct: 1473 QKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETD 1532
Query: 1545 TQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLAD 1604
QS + NIL INL+FV FT EC++K+ ALRHYYFT WNIFDFVVVILSIVG L+D
Sbjct: 1533 DQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSD 1592
Query: 1605 IIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1664
II+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFI
Sbjct: 1593 IIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1652
Query: 1665 FSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSL 1723
+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C
Sbjct: 1653 YSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC-- 1710
Query: 1724 DKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSE 1782
D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLSE
Sbjct: 1711 DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSE 1770
Query: 1783 DDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRI 1842
DDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLPMVSGDRI
Sbjct: 1771 DDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDRI 1830
Query: 1843 HCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVL 1902
HC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V+
Sbjct: 1831 HCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMVI 1890
Query: 1903 QRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKEST 1938
QRA+R HL +R F+ ++ + L E RE S
Sbjct: 1891 QRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSI 1950
Query: 1939 PSTASLPSYDSVTKPEKEKQQ 1959
ST+ PSYDSVT+ + Q
Sbjct: 1951 SSTSFPPSYDSVTRATSDNLQ 1971
>gi|237512980 voltage-gated sodium channel type V alpha isoform e
[Homo sapiens]
Length = 1983
Score = 2265 bits (5869), Expect = 0.0
Identities = 1247/2062 (60%), Positives = 1470/2062 (71%), Gaps = 212/2062 (10%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY++E + LGN+SALRTFRVLRALKTISVIPGLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLSALRTFRVLRALKTISVIPGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---RNFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG--- 653
SL +P RR+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPL--RRTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 654 ----GPGSHIGGRLLPEATTEVEIKKKGPG--SLLVS----MDQLASYGRKDRINSIMSV 703
PGSH+ ++ E + + PG +L S +D G + R S +SV
Sbjct: 609 PEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSV 668
Query: 704 VTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICI 763
+T+ L EELEES+ KCPPCW + A +LIWEC P W+ +K+ V L+VMDPF DL IT+CI
Sbjct: 669 LTSAL-EELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCI 727
Query: 764 VLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGF 823
VLNTLFMA+EH+ MT +FE +L VGNLVFTGIFTAEM K+IA+DPYYYFQ+GWNIFD
Sbjct: 728 VLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787
Query: 824 IVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLA 883
IV LSLMEL L+ + LSVLRSFRLLRVFKLAKSWPTLN LIKIIGNSVGALGNLTLVLA
Sbjct: 788 IVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLA 847
Query: 884 IIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWD 943
IIVFIFAVVGMQLFGK+Y E + + LPRWHM DFFH+FLI+FR+LCGEWIETMWD
Sbjct: 848 IIVFIFAVVGMQLFGKNYSE--LRDSDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWD 905
Query: 944 CMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIR 1003
CMEV+GQ++CL+VF++VMVIGNLVVLNLFLALLLSSFSADNL A D+D EMNNLQ+++ R
Sbjct: 906 CMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALAR 965
Query: 1004 IKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYE-KKANCIANHTGADIHRNGDFQKN 1062
I++G+ + K F +QR KP + + +CIA
Sbjct: 966 IQRGLRFVKRTTWDFCCGLLRQRPQ---KPAALAAQGQLPSCIATPYSPP---------- 1012
Query: 1063 GNGTTSGIGSSVEKYIIDEDHMSFINNPN--LTVRVPIAVGESDFE--------NLNTED 1112
T + + ++ +E P V VPIAV ESD + +L TE+
Sbjct: 1013 -PPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEE 1071
Query: 1113 VSSE---------------------------SDPEGSKDKLD------------------ 1127
SS+ S+ E S + D
Sbjct: 1072 ESSKQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGETP 1131
Query: 1128 DTSSSEGSTIDIKPE---VEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSW 1184
+ S SEGST D+ +E++P + ++ DP+ CFTEGCV+R CC V+ + GK W
Sbjct: 1132 EDSCSEGSTADMTNTAELLEQIP-DLGQDVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVW 1190
Query: 1185 WILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFI 1244
W LRKTC+ IVEH+WFETFIIFMILLSSGALAFEDIY+E+RKTI+ +LEYADK+FTY+F+
Sbjct: 1191 WRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFV 1250
Query: 1245 LEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPL 1304
LEMLLKW AYGF K+FTNAWCWLDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPL
Sbjct: 1251 LEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPL 1310
Query: 1305 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNET-SEI 1363
RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++
Sbjct: 1311 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDL 1370
Query: 1364 RFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAV 1423
VNNK++CE L E+ W VK+NFDNVGAGYLALLQVATFKGWMDIMYAAV
Sbjct: 1371 PLNYTIVNNKSQCESL--NLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAV 1428
Query: 1424 DSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTE 1483
DSR +EQP++E N+YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTE
Sbjct: 1429 DSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTE 1488
Query: 1484 EQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVET 1543
EQKKYYNAMKKLGSKKPQKPIPRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVET
Sbjct: 1489 EQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET 1548
Query: 1544 DTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLA 1603
D QS + NIL INL+FV FT G L+
Sbjct: 1549 DDQSPEKINILAKINLLFVAIFT--------------------------------GTVLS 1576
Query: 1604 DIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1663
DII+KYF SPTLFRVIRLARIGRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMF
Sbjct: 1577 DIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1636
Query: 1664 IFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCS 1722
I+SIFGM+NFAYVK EAGIDDMFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C
Sbjct: 1637 IYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC- 1695
Query: 1723 LDKEHPGS-GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLS 1781
D P S G +GDCG+P+VGI FF +YIIISFLIVVNMYIAIILENFSVATEES +PLS
Sbjct: 1696 -DPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLS 1754
Query: 1782 EDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDR 1841
EDDF+ FYEIWEKFDP+ATQFIEY L+DFADAL PLR+ KPN I LI MDLPMVSGDR
Sbjct: 1755 EDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAKPNQISLINMDLPMVSGDR 1814
Query: 1842 IHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVV 1901
IHC+DILFAFTKRVLG+SGE+D L+ QMEE+F+A+NPSK+SYEPITTTLRRK EEVSA+V
Sbjct: 1815 IHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSAMV 1874
Query: 1902 LQRAYRGHLARR-----GFICKKTTSNKL-ENGGTHRE------------------KKES 1937
+QRA+R HL +R F+ ++ + L E RE S
Sbjct: 1875 IQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSS 1934
Query: 1938 TPSTASLPSYDSVTKPEKEKQQ 1959
ST+ PSYDSVT+ + Q
Sbjct: 1935 ISSTSFPPSYDSVTRATSDNLQ 1956
>gi|110835710 sodium channel, voltage-gated, type X, alpha [Homo
sapiens]
Length = 1956
Score = 2060 bits (5336), Expect = 0.0
Identities = 1132/2024 (55%), Positives = 1395/2024 (68%), Gaps = 191/2024 (9%)
Query: 12 DSFKPFTPESLANIERRIAESKLKKPPKADGSHRED-DEDSKPKPNSDLEAGKSLPFIYG 70
++F+ FTPESL IE++IA + K KA HRE D++ KP+P DL+A LP YG
Sbjct: 11 NNFRRFTPESLVEIEKQIAAKQGTK--KAREKHREQKDQEEKPRPQLDLKACNQLPKFYG 68
Query: 71 DIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILI 130
++P L+ PLED DP+Y T +TF+VLN+G+T+ RFSAT AL++ SPFNLIRR AIK+ +
Sbjct: 69 ELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSV 128
Query: 131 HSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFL 190
HS FS+ I TIL NCV MT ++ P+ +EY FT IYTFE+L+KI+ARGFC++ FT+L
Sbjct: 129 HSWFSLFITVTILVNCVCMTRTDLPE---KIEYVFTVIYTFEALIKILARGFCLNEFTYL 185
Query: 191 RDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKK 250
RDPWNWLDFSVI +AY+ ++L +S LRTFRVLRALKT+SVIPGLK IVGALI SVKK
Sbjct: 186 RDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKK 245
Query: 251 LSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKT 310
L+DV ILT+FCLSVFAL+GLQLF GNL+NKCV + NE+ N + + YIN +
Sbjct: 246 LADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNET--TNYSSHRKPDIYINKR- 302
Query: 311 NFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQD 370
G +PLLCGN SD+G CP+GY C+K NP++ YTSFD+F+WAFL+LFRLMTQD
Sbjct: 303 ------GTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQD 356
Query: 371 YWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEA 430
WE LYQ TLR +GK YMIFFVLVIF+GSFYLVNLILAVV MAYEEQNQAT +E E KE
Sbjct: 357 SWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEK 416
Query: 431 EFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKE 490
+F+ LE L+K+QE A + T++ GSP L+SK+A E
Sbjct: 417 KFQEALEMLRKEQEVLAALGIDTTSL-----------HSHNGSP--------LTSKNASE 457
Query: 491 RRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSI 550
RR+R K R +SEG + DN+ R NQ +S
Sbjct: 458 RRHRIKPR----VSEGSTE-----------------------DNKSPRS-DPYNQRRMSF 489
Query: 551 PGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARER 610
G R S S+F FR PGR S E D+ + E R SL +
Sbjct: 490 LGLASGKRRASHGSVFHFRSPGR---DISLPEGVTDDGVFPGDHESHRGSLLL------- 539
Query: 611 RSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATTE 670
G QG P R+ + + PG+ +
Sbjct: 540 -----GGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGA-----------VD 583
Query: 671 VEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTF 730
V G +S + L R R S++S++T+ L EELEES++KCPPC + +
Sbjct: 584 VSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVL-EELEESEQKCPPCLTSLSQKY 642
Query: 731 LIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL 790
LIW+C P W+KLK I+ +V DPF +L IT+CIV+NT+FMAMEHH M+P FE +L +GN+
Sbjct: 643 LIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNI 702
Query: 791 VFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLR 850
VFT FTAEM K+IA DPYYYFQ+ WNIFD IV++SL+EL +A LSVLRSFRLLR
Sbjct: 703 VFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLR 762
Query: 851 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQ 910
VFKLAKSWPTLN LIKIIGNSVGALGNLT++LAIIVF+FA+VG QL G++Y+ I+
Sbjct: 763 VFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISA 822
Query: 911 DCE-LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVL 969
E PRWHMHDFFHSFLIVFR+LCGEWIE MW CMEV +++CLI+F+ VMV+GNLVVL
Sbjct: 823 PHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVL 882
Query: 970 NLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFM--QAHFKQRE 1027
NLF+ALLL+SFSADNL A +DDGE+NNLQ+++ RI+ TK + +F F Q +
Sbjct: 883 NLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPK 942
Query: 1028 AD-EVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSF 1086
A+ E+ L KA NH A+ R G++ G+ + ++H F
Sbjct: 943 AEPELVVKLPLSSSKAE---NHIAANTAR---------GSSGGLQAPRGP---RDEHSDF 987
Query: 1087 INNPNLTVRVPIAVGESDFENL-------------------------------------- 1108
I NP + V VPIA GESD ++L
Sbjct: 988 IANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRS 1047
Query: 1109 -----NTEDVS--------SESDPEGSKDKLDDTSSSEGSTID-IKPE--VEEVPVEQPE 1152
++ED++ ES P+ + +DDTSSSEGST+D + PE + ++P E +
Sbjct: 1048 PGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIP-ELAD 1106
Query: 1153 EYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSS 1212
+ +PD CFTEGC++ CC+++ + W +RKTC+ IVEH+WFE+FIIFMILLSS
Sbjct: 1107 DLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSS 1166
Query: 1213 GALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIV 1272
G+LAFED Y++Q+ T++ +LEY D+VFT+IF+ EMLLKW AYGF K+FTNAWCWLDFLIV
Sbjct: 1167 GSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIV 1226
Query: 1273 AVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLL 1332
+SL+SL A L YSE+ IK+LRTLRALRPLRALSRFEGMRVVV+ALVGAIPSIMNVLL
Sbjct: 1227 NISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLL 1286
Query: 1333 VCLIFWLIFSIMGVNLFAGKYHYCFNETSE--IRFEIEDVNNKTECEKLMEGNNTEIRWK 1390
VCLIFWLIFSIMGVNLFAGK+ C N T + VNNK++C+ ++ + W
Sbjct: 1287 VCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCK--IQNSTGSFFWV 1344
Query: 1391 NVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIF 1450
NVK+NFDNV GYLALLQVATFKGWMDIMYAAVDSR+ + QPK+EDN+YMY+YFVIFIIF
Sbjct: 1345 NVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIF 1404
Query: 1451 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1510
G FFTLNLF+GVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK
Sbjct: 1405 GGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1464
Query: 1511 IQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECV 1570
QG VFD VT+QAFDI IM+LICLNM+TMMVETD QS++ IL IN FV FT ECV
Sbjct: 1465 FQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECV 1524
Query: 1571 LKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIE--KYFVSPTLFRVIRLARIGRIL 1628
+KMFALR YYFT GWN+FDF+VV+LSI + + I++ + + SPTLFRVIRLARIGRIL
Sbjct: 1525 MKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRIL 1584
Query: 1629 RLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNF 1688
RLI+ AKGIRTLLFALMMSLPALFNIGLLLFLVMFI+SIFGMS+F +V+ EAGIDDMFNF
Sbjct: 1585 RLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNF 1644
Query: 1689 ETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSLDKEHPGS-GFKGDCGNPSVGIFFF 1746
+TF NSM+CLFQITTSAGWDGLL PILN PP C D P S G +GDCG+P+VGI FF
Sbjct: 1645 QTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC--DPNLPNSNGTRGDCGSPAVGIIFF 1702
Query: 1747 VSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYC 1806
+YIIISFLI+VNMYIA+ILENF+VATEES +PLSEDDF+ FYE WEKFDP+ATQFI +
Sbjct: 1703 TTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFS 1762
Query: 1807 KLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILR 1866
L+DFAD L PLR+PKPN LI MDLP+V GD+IHCLDILFAFTK VLG+SGELD L+
Sbjct: 1763 ALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLK 1822
Query: 1867 QQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKT------ 1920
MEE+F+A+N SK SYEPI TTLR KQE++SA V+Q+AYR ++ R T
Sbjct: 1823 ANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRA 1882
Query: 1921 --TSNKLENGG----------THREKKESTPSTASLPSYDSVTK 1952
+ L + G +K E+ +T+ PSY+SVT+
Sbjct: 1883 EEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTR 1926
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 1803 bits (4669), Expect = 0.0
Identities = 915/1235 (74%), Positives = 1026/1235 (83%), Gaps = 53/1235 (4%)
Query: 709 VEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTL 768
+EELEE+ +KCPP WYK A+ LIW C W+K K I++LIVMDPFVDL ITICIVLNTL
Sbjct: 534 MEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLGITICIVLNTL 593
Query: 769 FMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLS 828
FMAMEH+PMT F++VL VGNLVFTGIFTAEM LKLIAMDPY YFQ+GWNIFD IV+LS
Sbjct: 594 FMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSIIVTLS 653
Query: 829 LMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 888
L+EL LA+V+GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI
Sbjct: 654 LVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFI 713
Query: 889 FAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVA 948
FAVVGMQLFGKSYKECVCKI DC LPRWHMHDFFHSFLIVFR+LCGEWIETMWDCMEVA
Sbjct: 714 FAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVA 773
Query: 949 GQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGV 1008
GQAMCL VF+MVMVIGNLVVLNLFLALLLSSFSAD+LAA+D+DGEMNNLQI++ RIK G+
Sbjct: 774 GQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGI 833
Query: 1009 AWTKLKVHAFMQAHF-----------------KQREADEVKPLDELYE------KKANCI 1045
+ K + + + EA E P DE E KK N I
Sbjct: 834 GFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHI 893
Query: 1046 ANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDF 1105
NH G G SS+E DH++FINNP LT++VPIA ESD
Sbjct: 894 LNHMGL---------------ADGPPSSLEL-----DHLNFINNPYLTIQVPIASEESDL 933
Query: 1106 ENLNTEDVSSESDPEGSK---DKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLD---PDA 1159
E E+ + S+PE SK L D +SS ST D KP EE P EQ EE + P+
Sbjct: 934 EMPTEEETDTFSEPEDSKKPPQPLYDGNSSVCSTADYKPP-EEDPEEQAEENPEGEQPEE 992
Query: 1160 CFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFED 1219
CFTE CVQR+ C V+I +G GK WW LR+ CF IVEHNWFETFI+FMILLSSGALAFED
Sbjct: 993 CFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFED 1052
Query: 1220 IYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSL 1279
IYIEQR+ IRTILEYADKVFTYIFI+EMLLKW AYGF +FTNAWCWLDFLIV VS++SL
Sbjct: 1053 IYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISL 1112
Query: 1280 IANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWL 1339
+AN LGYSELG IKSLRTLRALRPLRALSRFEGMRVVVNAL+GAIPSIMNVLLVCLIFWL
Sbjct: 1113 VANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWL 1172
Query: 1340 IFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNV 1399
IFSIMGVNLFAGK++YC N T+ RF+I +VNNK+ECE LM + ++RW NVK+N+DNV
Sbjct: 1173 IFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESLM--HTGQVRWLNVKVNYDNV 1230
Query: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459
G GYL+LLQVATFKGWMDIMYAAVDSR+ +EQP+YE N+YMY+YFVIFIIFGSFFTLNLF
Sbjct: 1231 GLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLF 1290
Query: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFV 1519
IGVIIDNFNQQKKK GG+DIFMTEEQKKYYNAMKKLGSKKPQKPIPRP NKIQG+V+D V
Sbjct: 1291 IGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLV 1350
Query: 1520 TQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY 1579
T+QAFDI IM+LICLNMVTMMVETD QS+ +ILY IN++F+I FT ECVLKM ALR Y
Sbjct: 1351 TKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALRQY 1410
Query: 1580 YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRT 1639
YFT+GWNIFDFVVVILSIVG+ L+D+I+KYFVSPTLFRVIRLARIGR+LRLI+GAKGIRT
Sbjct: 1411 YFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIGRVLRLIRGAKGIRT 1470
Query: 1640 LLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLF 1699
LLFALMMSLPALFNIGLLLFLVMFI+SIFGMSNFAYVK E+GIDDMFNFETFGNS+ICLF
Sbjct: 1471 LLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLF 1530
Query: 1700 QITTSAGWDGLLLPILNR-PPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVV 1758
+ITTSAGWDGLL PILN PPDC + E+PG+ KGDCGNPS+GI FF SYIIISFLIVV
Sbjct: 1531 EITTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVV 1590
Query: 1759 NMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHP 1818
NMYIAIILENF+VATEES++PL EDDFE FYE WEKFDPDATQFI Y +L+DF D L+ P
Sbjct: 1591 NMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEP 1650
Query: 1819 LRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNP 1878
LR+ KPN I+LI +DLPMV GD+IHCLDILFA TK VLGDSGE+D L+Q MEE+F+A+NP
Sbjct: 1651 LRIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANP 1710
Query: 1879 SKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARR 1913
SKVSYEPITTTL+RK EEV A+ +QRAYR HL +R
Sbjct: 1711 SKVSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQR 1745
Score = 653 bits (1684), Expect = 0.0
Identities = 337/552 (61%), Positives = 400/552 (72%), Gaps = 59/552 (10%)
Query: 6 LAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSL 65
L P GP+ +PFT ESLA IE+R E + + + + + E+ + KP SDLEAGK+L
Sbjct: 9 LVPLGPECLRPFTRESLAAIEQRAVEEEAR----LQRNKQMEIEEPERKPRSDLEAGKNL 64
Query: 66 PFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIA 125
P IYGD P ++ +PLED DPYY +KTF+VLN+GK +FRFSATPALY+LSPF+++RR A
Sbjct: 65 PMIYGDPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALYLLSPFSVVRRGA 124
Query: 126 IKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFCID 185
IK+LIH++FSM IM TILTNCVFMT S+PP WSKNVEYTFTGIYTFESL+KI+ARGFC+D
Sbjct: 125 IKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILARGFCVD 184
Query: 186 GFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALI 245
FTFLRDPWNWLDFSVIMMAY+TEFV+LGN+SALRTFRVLRALKTI+VIPGLKTIVGALI
Sbjct: 185 DFTFLRDPWNWLDFSVIMMAYLTEFVDLGNISALRTFRVLRALKTITVIPGLKTIVGALI 244
Query: 246 QSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINF----------------- 288
QSVKKLSDVMILTVFCLSVFAL+GLQLFMGNLR KCV WP F
Sbjct: 245 QSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGND 304
Query: 289 ----------NESYLENGT----------KGFDWEEYINNKTNFYTVPGMLEPLLCGNSS 328
N+S+ N T FDW+ YI+++ NFY + G + LLCGNSS
Sbjct: 305 TWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSS 364
Query: 329 DAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM 388
DAG CPEGY+C+K GRNPNYGYTS+DTFSWAFLALFRLMTQDYWENL+QLTLRAAGKTYM
Sbjct: 365 DAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM 424
Query: 389 IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQA 448
IFFV++IF+GSFYL+NLILAVVAMAY EQN+ATL E ++KE EF+ MLE+ KK QEE +
Sbjct: 425 IFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKKHQEELEK 484
Query: 449 AAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRK--------Q 500
A A + EG E G P + + S E+ R+
Sbjct: 485 AKAAQAL----------EGGEADGDPAHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAM 534
Query: 501 KELSEGEEKGDP 512
+EL E +K P
Sbjct: 535 EELEEAHQKCPP 546
Score = 89.7 bits (221), Expect = 2e-17
Identities = 103/434 (23%), Positives = 180/434 (41%), Gaps = 105/434 (24%)
Query: 12 DSFKPFTPESLANIERRIAESKLKKPPKADGSHR--EDDEDSKPKPNSDLEAGKSLPFIY 69
DS KP P+ L + + + KPP+ D + E+ E +P+ + P +Y
Sbjct: 949 DSKKP--PQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLY 1006
Query: 70 GDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKIL 129
DI QG RGK + +RR KI+
Sbjct: 1007 VDISQG-----------------------RGKKWWT---------------LRRACFKIV 1028
Query: 130 IHSVFSMIIMCTILTNCVFMTFSNPPDWSKNV-----EYT---FTGIYTFESLVKIIARG 181
H+ F I+ IL + + F + + V EY FT I+ E L+K +A G
Sbjct: 1029 EHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYG 1088
Query: 182 FCIDGFTFLRDPWNWLDFSVIMMAYITEFVN------LGNVSALRTFRVLRALKTISVIP 235
F + + + W WLDF ++ ++ I+ N LG + +LRT R LR L+ +S
Sbjct: 1089 FKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLRALSRFE 1144
Query: 236 GLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLEN 295
G++ +V AL+ ++ + +V+++ + +F+++G+ LF G + IN S
Sbjct: 1145 GMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-----YYCINTTTS---- 1195
Query: 296 GTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDT 355
+ FD E +NNK+ C + GQ R N ++D
Sbjct: 1196 --ERFDISE-VNNKSE------------CESLMHTGQV----------RWLNV-KVNYDN 1229
Query: 356 FSWAFLALFRLMTQDYWENLYQLTLRAAGK---------TYM-IFFVLVIFVGSFYLVNL 405
+L+L ++ T W ++ + + K YM ++FV+ I GSF+ +NL
Sbjct: 1230 VGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNL 1289
Query: 406 ILAVVAMAYEEQNQ 419
+ V+ + +Q +
Sbjct: 1290 FIGVIIDNFNQQKK 1303
Score = 74.7 bits (182), Expect = 8e-13
Identities = 50/187 (26%), Positives = 98/187 (52%), Gaps = 13/187 (6%)
Query: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783
++F+ T ++ P+ + + + +++ F + I I I+ N +FM M P P ++
Sbjct: 103 FRFSATPALYLLSPFSVVRRGAIKVLIHALF-SMFIMITILTNCVFMTMSDPP--PWSKN 159
Query: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839
V FTGI+T E +K++A +D + + ++ WN D ++ ++ + D+
Sbjct: 160 V----EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT-EFVDLGN 214
Query: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898
+S LR+FR+LR K P L ++ + SV L ++ ++ + +FA+VG+QLF G
Sbjct: 215 ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
Query: 899 KSYKECV 905
++CV
Sbjct: 275 NLRQKCV 281
Score = 73.9 bits (180), Expect = 1e-12
Identities = 58/222 (26%), Positives = 104/222 (46%), Gaps = 25/222 (11%)
Query: 1138 DIKPEVEEVPVEQPEEYLDPDACF---TEG-CVQRFKCCQVNIEEGLGKSWWILRKTCFL 1193
D PEV +P+E + Y F +G + RF L + ++R+
Sbjct: 70 DPPPEVIGIPLEDLDPYYSNKKTFIVLNKGKAIFRFSATPALY---LLSPFSVVRRGAIK 126
Query: 1194 IVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTA 1253
++ H F FI+ IL + + D + +EY FT I+ E L+K A
Sbjct: 127 VLIHALFSMFIMITILTNCVFMTMSDPPPWSKN-----VEYT---FTGIYTFESLIKILA 178
Query: 1254 YGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSR 1309
GF F + W WLDF ++ ++A + +LG I +LRT R LR L+ ++
Sbjct: 179 RGFCVDDFTFLRDPWNWLDFSVI------MMAYLTEFVDLGNISALRTFRVLRALKTITV 232
Query: 1310 FEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG 1351
G++ +V AL+ ++ + +V+++ + +F+++G+ LF G
Sbjct: 233 IPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMG 274
Score = 67.4 bits (163), Expect = 1e-10
Identities = 47/174 (27%), Positives = 87/174 (50%), Gaps = 12/174 (6%)
Query: 116 SPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPP--DWSKNV----EYTFTGIY 169
+P+ + I I++ + I I+ N +FM + P + NV FTGI+
Sbjct: 562 APWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIF 621
Query: 170 TFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYIT-EFVNLGNVSALRTFRVLRAL 228
T E ++K+IA +D + + + WN D ++ ++ + N+ +S LR+FR+LR
Sbjct: 622 TAEMVLKLIA----MDPYEYFQQGWNIFDSIIVTLSLVELGLANVQGLSVLRSFRLLRVF 677
Query: 229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV 282
K P L ++ + SV L ++ ++ + +FA++G+QLF G +CV
Sbjct: 678 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSYKECV 730
Score = 38.1 bits (87), Expect = 0.086
Identities = 18/72 (25%), Positives = 41/72 (56%)
Query: 922 FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981
F +FL +FR++ ++ E ++ A +I F++++ +G+ ++NL LA++ +++
Sbjct: 392 FSWAFLALFRLMTQDYWENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYA 451
Query: 982 ADNLAATDDDGE 993
N A +D E
Sbjct: 452 EQNEATLAEDKE 463
Score = 36.6 bits (83), Expect = 0.25
Identities = 24/100 (24%), Positives = 45/100 (45%), Gaps = 10/100 (10%)
Query: 1395 NFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFF 1454
++D +LAL ++ T W ++ + + YM I+FV+ I GSF+
Sbjct: 388 SYDTFSWAFLALFRLMTQDYWENLFQLTL---------RAAGKTYM-IFFVVIIFLGSFY 437
Query: 1455 TLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKK 1494
+NL + V+ + +Q + +D EE ++ KK
Sbjct: 438 LINLILAVVAMAYAEQNEATLAEDKEKEEEFQQMLEKFKK 477
>gi|115583667 sodium channel, voltage-gated, type XI, alpha [Homo
sapiens]
Length = 1791
Score = 1281 bits (3315), Expect = 0.0
Identities = 691/1301 (53%), Positives = 899/1301 (69%), Gaps = 95/1301 (7%)
Query: 683 VSMDQLASYG---RKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYW 739
+S+D +G ++ R S +S++T T+ E+ E+SQ C PC A+ +L+W C P W
Sbjct: 505 LSLDHFDEHGDPLQRQRALSAVSILTITMKEQ-EKSQEPCLPCGENLASKYLVWNCCPQW 563
Query: 740 IKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAE 799
+ +K+++ ++ DPF +LAITICI++NT+F+AMEHH M FE +L +GNLVFT IF AE
Sbjct: 564 LCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAE 623
Query: 800 MFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLS--VLRSFRLLRVFKLAKS 857
M LK+IA+DPY+YF+ GWNIFD + LS ++ ++ S LRSFR+LRVFKLAKS
Sbjct: 624 MCLKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKS 683
Query: 858 WPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCE---- 913
WPTLN LIKIIGNSVGALG+LT+VL I++FIF+VVGMQLFG+S+ K + C
Sbjct: 684 WPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ--KSPKLCNPTGP 741
Query: 914 ----LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVFMMVMVIGNLV 967
L WHM DF+HSFL+VFR+LCGEWIE MW+CM+ A ++C+IVF+++ VIG LV
Sbjct: 742 TVSCLRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLV 801
Query: 968 VLNLFLALLLSSFSADNLAAT-DDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQR 1026
VLNLF+ALLL+SFS + + + +Q+++ R ++ + + + F +++
Sbjct: 802 VLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRKQ 861
Query: 1027 EADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIG--SSVEKYI------ 1078
+ K E C A DI K G+ T +G +SV K +
Sbjct: 862 NLPQQK------EVAGGCAAQ--SKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDW 913
Query: 1079 -------IDEDHMSFINNPNLTVRVPIAVGESDFENLNTE--------------DVSSES 1117
+ED + F N R+ E L+ E D+ SE
Sbjct: 914 TWLAPLAEEEDDVEFSGEDNAQ-RITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSED 972
Query: 1118 DP----EGSKDKLDDTSS-SEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCC 1172
+P + + K D TS SE STID++ +P P++ P+ C +G F CC
Sbjct: 973 EPHLTIQDPRKKSDVTSILSECSTIDLQDGFGWLPEMVPKK--QPERCLPKGFGCCFPCC 1030
Query: 1173 QVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTIL 1232
V+ + WW LRKTC+ IV+H+WFE+FIIF+ILLSSGAL FED+++E + I+ +L
Sbjct: 1031 SVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELL 1090
Query: 1233 EYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1292
D +FT+IFILEM+LKW A+GF K+FT+AWC LDF+IV VS+ +LI L +
Sbjct: 1091 NCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLI-------NLMEL 1143
Query: 1293 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK 1352
KS RTLRALRPLRALS+FEGM+VVVNAL+GAIP+I+NVLLVCLIFWL+F I+GV F+GK
Sbjct: 1144 KSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGK 1203
Query: 1353 YHYCFNET-SEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVAT 1411
+ C N T S I + I + NK++CE GN W N K+NFDNVG YLALLQVAT
Sbjct: 1204 FGKCINGTDSVINYTI--ITNKSQCES---GN---FSWINQKVNFDNVGNAYLALLQVAT 1255
Query: 1412 FKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQK 1471
FKGWMDI+YAAVDS + ++QP++E N YIYFV+FIIFGSFFTLNLFIGVIIDNFNQQ+
Sbjct: 1256 FKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQ 1315
Query: 1472 KKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMML 1531
KK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK QG+VFD VT Q FDI+I+ L
Sbjct: 1316 KKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISL 1375
Query: 1532 ICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFV 1591
I LNM++MM E+ Q K M++IL +N VFV+ FT EC++K+FALR YYFT GWN+FD V
Sbjct: 1376 IILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCV 1435
Query: 1592 VVILSIVGMFLADIIEKYFV--SPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLP 1649
VV+LSIV ++ + + + PTLFR++RLARIGRILRL++ A+GIRTLLFALMMSLP
Sbjct: 1436 VVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLP 1495
Query: 1650 ALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDG 1709
+LFNIGLLLFL+MFI++I GM+ F+ V E+GIDD+FNF+TF +SM+CLFQI+TSAGWD
Sbjct: 1496 SLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDS 1555
Query: 1710 LLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1769
LL P+L C+ E +C P + +FVSYIIISFLIVVNMYIA+ILENF
Sbjct: 1556 LLSPMLRSKESCNSSSE--------NCHLPGIATSYFVSYIIISFLIVVNMYIAVILENF 1607
Query: 1770 SVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIEL 1829
+ ATEES DPL EDDF+ FYE+WEKFDP+ATQFI+Y L+DFADAL PLRV KPN +
Sbjct: 1608 NTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAKPNKYQF 1667
Query: 1830 IAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTT 1889
+ MDLPMVS DR+HC+DILFAFT RVLG S LD ++ MEE+F+ +NP K YEPI TT
Sbjct: 1668 LVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLKKLYEPIVTT 1727
Query: 1890 LRRKQEEVSAVVLQRAYRGHLAR--RGFICKKTTSNKLENG 1928
+RK+EE A ++Q+A+R ++ + +G + N LENG
Sbjct: 1728 TKRKEEERGAAIIQKAFRKYMMKVTKG---DQGDQNDLENG 1765
Score = 399 bits (1026), Expect = e-110
Identities = 223/457 (48%), Positives = 291/457 (63%), Gaps = 23/457 (5%)
Query: 9 PGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFI 68
P +F+PFT +SLA IE+RIA K KK K + E +P+P DL+A + LP +
Sbjct: 11 PDERNFRPFTSDSLAAIEKRIAIQKEKKKSKD-----QTGEVPQPRPQLDLKASRKLPKL 65
Query: 69 YGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKI 128
YGDIP+ L+ PLED DP+Y KTF+VLNR +T++RFSA AL+I PFN IR +AI++
Sbjct: 66 YGDIPRELIGKPLEDLDPFYRNHKTFMVLNRKRTIYRFSAKHALFIFGPFNSIRSLAIRV 125
Query: 129 LIHSVFSMIIMCTILTNCVFMTFSNPPDWSKN----VEYTFTGIYTFESLVKIIARGFCI 184
+HS+FSM I+ T++ NCVFM + + N E FTGIY FE+L+KI+ARGF +
Sbjct: 126 SVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFIL 185
Query: 185 DGFTFLRDPWNWLDFSVIMMAYITEFVNLG-NVSALRTFRVLRALKTISVIPGLKTIVGA 243
D F+FLRDPWNWLD VI +A ++ + + LRTFRV RALK ISV+ LK IVGA
Sbjct: 186 DEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGA 245
Query: 244 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWE 303
L++SVKKL +V+ILT FCLS+FAL+G QLFMG+L KC+ N S E F+ +
Sbjct: 246 LLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCK-NISNPEAYDHCFEKK 304
Query: 304 EYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLAL 363
E N F +CG C Y+C NP+Y YT+FD F W+FLA+
Sbjct: 305 E---NSPEFK---------MCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAM 352
Query: 364 FRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLE 423
FRLMTQD WE LYQ TLR G + FF++VIF+GSFYL+NL LAVV MAYEEQN+
Sbjct: 353 FRLMTQDSWEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAA 412
Query: 424 EAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSE 460
E E KE F+ + LK+++E A + S+ T E
Sbjct: 413 EIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSLTSLE 449
Score = 105 bits (263), Expect = 3e-22
Identities = 81/337 (24%), Positives = 151/337 (44%), Gaps = 46/337 (13%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
+R + H+ F FII ++++ +A + + + A+ VFT I+I E
Sbjct: 118 IRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPA----KNSNSNNTDIAECVFTGIYIFE 173
Query: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302
L+K A GF+ F + W WLD +++ +++VS I + LRT R R
Sbjct: 174 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITI-----KLLPLRTFRVFR 228
Query: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGK---------- 1352
L+A+S ++V+V AL+ ++ ++NV+++ IF+++G LF G
Sbjct: 229 ALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDC 288
Query: 1353 --------YHYCF-NETSEIRFEIEDV-NNKTECEKLMEGNNTEIRWKNVKINFDNVGAG 1402
Y +CF + + F++ + + C E +T+I NFDN G
Sbjct: 289 KNISNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWS 348
Query: 1403 YLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGV 1462
+LA+ ++ T W K +Q +Y +F++ I GSF+ +NL + V
Sbjct: 349 FLAMFRLMTQDSW----------EKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAV 398
Query: 1463 IIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKK 1499
+ + +Q K + + ++K + A + L +K
Sbjct: 399 VTMAYEEQNKNVAAE---IEAKEKMFQEAQQLLKEEK 432
Score = 87.0 bits (214), Expect = 2e-16
Identities = 79/321 (24%), Positives = 141/321 (43%), Gaps = 71/321 (22%)
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFS-----NPPDWSKNVEYT---FTGIYTFE 172
+R+ +I+ HS F I+ IL + + F N P + + T FT I+ E
Sbjct: 1045 LRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILE 1104
Query: 173 SLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTIS 232
++K +A GF + W LDF +++++ +T +NL + + RT R LR L+ +S
Sbjct: 1105 MVLKWVAFGFG----KYFTSAWCCLDFIIVIVS-VTTLINLMELKSFRTLRALRPLRALS 1159
Query: 233 VIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESY 292
G+K +V ALI ++ + +V+++ + VF ++G+ F G KC+
Sbjct: 1160 QFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILGVYFFSGKF-GKCI---------- 1208
Query: 293 LENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGY-- 350
NGT + IN YT+ ++ QC G N+ +
Sbjct: 1209 --NGT-----DSVIN-----YTI-----------ITNKSQCESG----------NFSWIN 1235
Query: 351 --TSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM----------IFFVLVIFVG 398
+FD A+LAL ++ T W ++ + + K I+FV+ I G
Sbjct: 1236 QKVNFDNVGNAYLALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFG 1295
Query: 399 SFYLVNLILAVVAMAYEEQNQ 419
SF+ +NL + V+ + +Q +
Sbjct: 1296 SFFTLNLFIGVIIDNFNQQQK 1316
Score = 68.6 bits (166), Expect = 6e-11
Identities = 57/271 (21%), Positives = 114/271 (42%), Gaps = 51/271 (18%)
Query: 763 IVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWN 818
+++N +FMA P + + VFTGI+ E +K++A +D + + ++ WN
Sbjct: 139 VIINCVFMATG--PAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 196
Query: 819 IFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNL 878
D ++ ++++ L LR+FR+ R K L +++ + SV L N+
Sbjct: 197 WLDSIVIGIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNV 256
Query: 879 TLVLAIIVFIFAVVGMQLF------------------GKSYKEC---------------- 904
++ + IFA+VG QLF ++Y C
Sbjct: 257 IILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNISNPEAYDHCFEKKENSPEFKMCGIW 316
Query: 905 ----VCKINQDCELPR-------WHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC 953
C I +C+ + + +F SFL +FR++ + E ++
Sbjct: 317 MGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYS 376
Query: 954 LIVFMMVMVIGNLVVLNLFLALLLSSFSADN 984
+ F++V+ +G+ ++NL LA++ ++ N
Sbjct: 377 VFFFIVVIFLGSFYLINLTLAVVTMAYEEQN 407
Score = 67.8 bits (164), Expect = 1e-10
Identities = 62/332 (18%), Positives = 134/332 (40%), Gaps = 67/332 (20%)
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSN---PPDWSKNVEY---TFTGIYTFESL 174
++++ ++ + I I+ N VF+ + + K + FT I+ E
Sbjct: 566 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
Query: 175 VKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEF---VNLGNVSALRTFRVLRALKTI 231
+KIIA +D + + R WN D V ++++ + + LR+FRVLR K
Sbjct: 626 LKIIA----LDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLA 681
Query: 232 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNES 291
P L T++ + SV L + ++ V + +F+++G+QLF + ++
Sbjct: 682 KSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQ----------- 730
Query: 292 YLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYT 351
P LC + C +
Sbjct: 731 ---------------------------KSPKLCNPTGPTVSCLRHWH------------- 750
Query: 352 SFDTFSWAFLALFRLMTQDYWENLYQL--TLRAAGKTYMIFFVLVIFVGSFYLVNLILAV 409
F +FL +FR++ ++ EN+++ A+ +I F+L+ +G ++NL +A+
Sbjct: 751 -MGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNLFIAL 809
Query: 410 VAMAYEEQNQATLEEAEQKEAEFKAMLEQLKK 441
+ ++ + + E E ++ + + L++ ++
Sbjct: 810 LLNSFSNEERNGNLEGEARKTKVQLALDRFRR 841
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/185 (23%), Positives = 87/185 (47%), Gaps = 24/185 (12%)
Query: 107 SATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNV--- 161
S P I P N + + I+ +F +II+ I+ N + M N P K++
Sbjct: 1341 SKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYNQPKAMKSILDH 1400
Query: 162 -EYTFTGIYTFESLVKIIA-RGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN-LGN--- 215
+ F I+T E L+KI A R + + + WN D V++++ ++ ++ L N
Sbjct: 1401 LNWVFVVIFTLECLIKIFALRQY------YFTNGWNLFDCVVVLLSIVSTMISTLENQEH 1454
Query: 216 -------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALI 268
+R R+ R L+ + G++T++ AL+ S+ L ++ +L + ++A++
Sbjct: 1455 IPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAIL 1514
Query: 269 GLQLF 273
G+ F
Sbjct: 1515 GMNWF 1519
>gi|111378393 sodium channel, voltage-gated, type VII, alpha [Homo
sapiens]
Length = 1682
Score = 1266 bits (3276), Expect = 0.0
Identities = 647/1247 (51%), Positives = 870/1247 (69%), Gaps = 37/1247 (2%)
Query: 668 TTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFA 727
T ++E+KK+ P S S+D L + + EELE+S++ CP WYKFA
Sbjct: 433 TIQIEMKKRSPISTDTSLDVLEDATLRHK-------------EELEKSKKICPLYWYKFA 479
Query: 728 NTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAV 787
TFLIW C P W+KLKE V+ I+M PF DL + ICI+LN F+ +EH+PM+ Q +L +
Sbjct: 480 KTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNI 539
Query: 788 GNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFR 847
GNLVF GIFTAEM K+IAM PY YFQ GWNIFD IV L+EL LA+V G+++LR FR
Sbjct: 540 GNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFR 599
Query: 848 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCK 907
+LR+FKL K WPT +L+ + NS AL +L L+L +F A GM+LFGK+Y+E VC
Sbjct: 600 MLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCH 659
Query: 908 INQDCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLV 967
I++DC+LPRWHMHDFFHSFL VFR+LCGEW+ET+WDCMEVAGQ+ C+ ++MV++IGNL+
Sbjct: 660 IDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLL 719
Query: 968 VLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE 1027
VL LFLAL+ SSFS+ +++ E NLQ++V RIKKG+ + LK+ Q K
Sbjct: 720 VLYLFLALV-SSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPK--- 775
Query: 1028 ADEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFI 1087
D + ++E+Y K+ I++HT +++ DF K+ + S EK + + S I
Sbjct: 776 -DTMDHVNEVYVKED--ISDHTLSELSNTQDFLKDKEKS-----SGTEKNATENESQSLI 827
Query: 1088 NNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVP 1147
+P+++ VPIA GESD ENL+ +++ S+S GSK+K+ +SSSE ST+DI EE
Sbjct: 828 PSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEM 887
Query: 1148 VEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFM 1207
E GC + Q++ GK W +RKTC IVE+NWF+ FI +
Sbjct: 888 FYGGER----SKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLV 943
Query: 1208 ILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWL 1267
LLS+G LAFEDIY++QRKTI+ +LEYAD +FTYIFILEMLLKW AYGF +F+N W L
Sbjct: 944 TLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRL 1003
Query: 1268 DFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSI 1327
DF++V V +SLI +K L +++ LRPLR LS+FE M+VVV AL+
Sbjct: 1004 DFVVVIVFCLSLIGKTRE-----ELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPT 1058
Query: 1328 MNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEI 1387
+NV LVCL+ WLIFSIMGV+LFAG+++ C + TS RF +V NK+ CE L+ N +
Sbjct: 1059 LNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLF--NESM 1116
Query: 1388 RWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIF 1447
W+N K+NFDNVG G+L+LLQVATF GW+ IM +A+DS + QP +E NIYMY YF+ F
Sbjct: 1117 LWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINF 1176
Query: 1448 IIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP 1507
IIFG F L++ I VIIDNFN+ K K GG +IF+T +Q+K Y +KKL + Q+P+PRP
Sbjct: 1177 IIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRP 1236
Query: 1508 LNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTC 1567
LNK+QG +FD VT QAF++++M+LIC + MM++TD QS QM LYWIN +FV+ +T
Sbjct: 1237 LNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTM 1296
Query: 1568 ECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRI 1627
EC+LK+ A R +YFTI WNIFDF+VVI SI G+ L + Y V P+L ++I L+RI +
Sbjct: 1297 ECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHM 1356
Query: 1628 LRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFN 1687
LRL KG K L+ LM+SLPAL NI LL+FLVMFI+++FGM NFAYVK EAGI+D+ N
Sbjct: 1357 LRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSN 1416
Query: 1688 FETFGNSMICLFQITTSAGWDGLLLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFF 1746
FETFGNSM+CLFQ+ AGWDG+L I N + DC DK +PG+ +GDCGNPSVGIF+F
Sbjct: 1417 FETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYF 1476
Query: 1747 VSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYC 1806
VSYI+IS+LI+VNMYI +++E ++A+++ LSEDDF F+++W++FDPD TQ+I+
Sbjct: 1477 VSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSS 1536
Query: 1807 KLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILR 1866
KL+DFA AL+ PL + KPN +LIA+DLPM GDRIHCLDIL AFTKRV+G ++ +
Sbjct: 1537 KLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVV 1596
Query: 1867 QQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARR 1913
++E F+ +NP K++ EPITTTL+RKQE VSA ++QRAY+ + RR
Sbjct: 1597 SEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRR 1643
Score = 419 bits (1078), Expect = e-116
Identities = 219/445 (49%), Positives = 288/445 (64%), Gaps = 15/445 (3%)
Query: 5 LLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKS 64
+LA P P PFT ES I++ IA++ H ED E+ KP DLE GK
Sbjct: 1 MLASPEPKGLVPFTKESFELIKQHIAKT-----------HNEDHEEEDLKPTPDLEVGKK 49
Query: 65 LPFIYGDIPQGLVAVPLEDFDPYYLTQK-TFVVLNRGKTLFRFSATPALYILSPFNLIRR 123
LPFIYG++ QG+V+ PLED DPYY +K TF+VLN+ +T+FRF+A L LSPFN IRR
Sbjct: 50 LPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRR 109
Query: 124 IAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGFC 183
IK+L+H F + I+ ++L +CVFM+ +N P W +E T GIYTFE LVK+ ARG
Sbjct: 110 TTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVW 169
Query: 184 IDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGA 243
F+FL DPWNWLDFSV + I + L + L+T R LR LK I + GLK++VG
Sbjct: 170 AGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGV 229
Query: 244 LIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWE 303
LI +K+L V+ILT+F LS+F+LIG+ LFMGNL++KC WP L N T
Sbjct: 230 LIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGN---P 286
Query: 304 EYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLAL 363
YI NFY + G LLCGN +DAGQCPEGY C+KAG NP+ G+T+FD+F WA AL
Sbjct: 287 YYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFAL 346
Query: 364 FRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLE 423
FRLM QDY E LY L A+GK YMIFFV+V F+ SFY+ +L L ++AMAYEE+ Q E
Sbjct: 347 FRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGE 406
Query: 424 EAEQKEAEFKAMLEQLKKQQEEAQA 448
+++ E +F+ ++L++ E +A
Sbjct: 407 ISKKIEPKFQQTGKELQEGNETDEA 431
Score = 147 bits (371), Expect = 1e-34
Identities = 160/687 (23%), Positives = 294/687 (42%), Gaps = 140/687 (20%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
+R+T ++ H +F+ FI+ +L+ ++ ++ + T+L ++T+ +++
Sbjct: 107 IRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLG----IYTFEILVK 162
Query: 1247 MLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRA 1306
+ + G F + W WLDF + ++ + YS L I +L+T R LR L+
Sbjct: 163 LFARGVWAGSFSFLGDPWNWLDFSVTVFEVI------IRYSPLDFIPTLQTARTLRILKI 216
Query: 1307 LSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCF-------N 1358
+ +G++ +V L+ + ++ V+++ L F IFS++G+ LF G H CF N
Sbjct: 217 IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENEN 276
Query: 1359 ETSEIR----FEIEDVNN----KTECEKLMEGNNTE--------------IRWKNVKINF 1396
ET R + I + N + E L+ GN T+ I NF
Sbjct: 277 ETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNF 336
Query: 1397 DNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTL 1456
D+ G AL ++ + + +++Y Q Y I+FV+ SF+
Sbjct: 337 DSFGWALFALFRLMA-QDYPEVLY---------HQILYASGKVYMIFFVVVSFLFSFYMA 386
Query: 1457 NLFIGVIIDNFNQQKKKFGG----------------QDIFMTEEQKKYYNAMKKLGS--- 1497
+LF+G++ + ++K++ G Q+ T+E K MKK
Sbjct: 387 SLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPIST 446
Query: 1498 ------------------KKPQKPIP---------------RPL-NKIQGIVFDFVTQQA 1523
+K +K P P K++ V +
Sbjct: 447 DTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPF 506
Query: 1524 FDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY-YFT 1582
D+ +++ I LN+ + +E SKQ +L NLVF+ FT E + K+ A+ Y YF
Sbjct: 507 TDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQ 566
Query: 1583 IGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLF 1642
+GWNIFD ++V ++ + LA++ ++RL R+ RI +L K + L++
Sbjct: 567 VGWNIFDSMIVFHGLIELCLANVAG--------MALLRLFRMLRIFKLGKYWPTFQILMW 618
Query: 1643 ALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA--YVKHEAGID-----DMFNFETFGNSM 1695
+L S AL ++ LLLF +F + FGM F Y + ID ++ F +S
Sbjct: 619 SLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF 678
Query: 1696 ICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFL 1755
+ +F+I + L DC + S I F++ I+I L
Sbjct: 679 LNVFRILCGEWVETLW--------DCM------------EVAGQSWCIPFYLMVILIGNL 718
Query: 1756 IVVNMYIAIILENFSVATEESADPLSE 1782
+V+ +++A++ +FS + +A+ +E
Sbjct: 719 LVLYLFLALV-SSFSSCKDVTAEENNE 744
Score = 64.3 bits (155), Expect = 1e-09
Identities = 95/426 (22%), Positives = 173/426 (40%), Gaps = 87/426 (20%)
Query: 104 FRFSATPALYILSPFNLIRRIAIKILIHSVFS--MIIMCTILTNCVFMTFSNPPDWSKNV 161
++F+ T ++ SP L + + +I + F+ +I+C IL C F+T + P SK
Sbjct: 476 YKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVC-FLTLEHYP-MSKQT 533
Query: 162 E-------YTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITE-FVNL 213
F GI+T E + KIIA + + + + WN D ++ I N+
Sbjct: 534 NTLLNIGNLVFIGIFTAEMIFKIIA----MHPYGYFQVGWNIFDSMIVFHGLIELCLANV 589
Query: 214 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
++ LR FR+LR K P + ++ +L S L D+++L + A G++LF
Sbjct: 590 AGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLF 649
Query: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
G ++EE++ C D Q
Sbjct: 650 -------------------------GKNYEEFV-----------------CHIDKDC-QL 666
Query: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMI-FFV 392
P + F +FL +FR++ ++ E L+ + AG+++ I F++
Sbjct: 667 PRWH---------------MHDFFHSFLNVFRILCGEWVETLWD-CMEVAGQSWCIPFYL 710
Query: 393 LVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMA 452
+VI +G+ ++ L LA+V+ ++ T EE + + + + ++KK +
Sbjct: 711 MVILIGNLLVLYLFLALVS-SFSSCKDVTAEENNEAK-NLQLAVARIKKGINYVLLKILC 768
Query: 453 TSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDP 512
+ V +D ++ E S +S+LS N + K KE S G EK
Sbjct: 769 KTQ-NVPKDTMDHVNEVYVKEDISDHTLSELS--------NTQDFLKDKEKSSGTEKNAT 819
Query: 513 EKVFKS 518
E +S
Sbjct: 820 ENESQS 825
Score = 51.2 bits (121), Expect = 1e-05
Identities = 41/175 (23%), Positives = 86/175 (49%), Gaps = 13/175 (7%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPM-TPQFEHVLAVGNLVFTGIFTAEMFLKLIAM 807
+++ PF L I I ++++ +FM++ + P P E+ L GI+T E+ +KL A
Sbjct: 114 VLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLL-------GIYTFEILVKLFAR 166
Query: 808 D----PYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNM 863
+ + + WN D F V++ + + + ++ + L++ R LR+ K+ L
Sbjct: 167 GVWAGSFSFLGDPWNWLD-FSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKS 225
Query: 864 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWH 918
L+ ++ + + L + ++ + IF+++GM LF + K + Q+ E H
Sbjct: 226 LVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLH 280
Score = 48.9 bits (115), Expect = 5e-05
Identities = 53/208 (25%), Positives = 91/208 (43%), Gaps = 31/208 (14%)
Query: 121 IRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKNV----EYT---FTGIYTFE 172
IR+ KI+ ++ F I L + + F + D K + EY FT I+ E
Sbjct: 923 IRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILE 982
Query: 173 SLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGN-VSALRTFRVLRALKTI 231
L+K +A GF + + W LDF V+++ ++ + L + + LR L+ +
Sbjct: 983 MLLKWMAYGFK----AYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVL 1038
Query: 232 SVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG---------------- 275
S +K +V ALI++ +V ++ + +F+++G+ LF G
Sbjct: 1039 SQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPS 1098
Query: 276 -NLRNKCVVWPINFNESYL-ENGTKGFD 301
+ NK + FNES L EN FD
Sbjct: 1099 SEVMNKSRCESLLFNESMLWENAKMNFD 1126
Score = 44.3 bits (103), Expect = 0.001
Identities = 46/181 (25%), Positives = 83/181 (45%), Gaps = 25/181 (13%)
Query: 1507 PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFF 1565
P N I+ + F + I++ + ++ V M + + + +EN L I +
Sbjct: 103 PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGI-------Y 155
Query: 1566 TCECVLKMFALRHYYFTIG-----WNIFDFVVVILSIVGMFLA-DIIEKYFVSPTLFRVI 1619
T E ++K+FA + + WN DF V + ++ + D I PTL
Sbjct: 156 TFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFI------PTL---- 205
Query: 1620 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF-AYVKH 1678
+ AR RIL++I +G+++L+ L+ L L + +L + IFS+ GM F +KH
Sbjct: 206 QTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265
Query: 1679 E 1679
+
Sbjct: 266 K 266
>gi|239748090 PREDICTED: similar to sodium channel, voltage-gated,
type V, alpha (long QT syndrome 3) [Homo sapiens]
Length = 1637
Score = 984 bits (2544), Expect = 0.0
Identities = 541/843 (64%), Positives = 616/843 (73%), Gaps = 58/843 (6%)
Query: 968 VLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE 1027
VLNLFLALLLSSFSADNL A D+D EMNNLQ+++ RI++G+ + K F +QR
Sbjct: 631 VLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRP 690
Query: 1028 ADEVKPLDELYEKKA-NCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSF 1086
KP + + +CIA T G ++
Sbjct: 691 Q---KPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEG--------EQPGQGT 739
Query: 1087 INNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEV 1146
+P V VPIAV ESD + D+ +D +S G+ + + E
Sbjct: 740 PGDPE-PVCVPIAVAESDTD-----------------DQEEDEENSLGTEEESSKQQESQ 781
Query: 1147 PVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIF 1206
PV E +++ + + + + W E
Sbjct: 782 PVSGGPEAPPDSRTWSQVSATASSEAEASASQADWRQQWKAEPQAPGCGE---------- 831
Query: 1207 MILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCW 1266
AFEDIY+E+RKTI+ +LEYADK+FTY+F+LEMLLKW AYGF K+FTNAWCW
Sbjct: 832 ---------AFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCW 882
Query: 1267 LDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS 1326
LDFLIV VSLVSL+AN LG++E+G IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS
Sbjct: 883 LDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPS 942
Query: 1327 IMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETS-EIRFEIEDVNNKTECEKLMEGNNT 1385
IMNVLLVCLIFWLIFSIMGVNLFAGK+ C N+T ++ VNNK++CE L N T
Sbjct: 943 IMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESL---NLT 999
Query: 1386 -EIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYF 1444
E+ W VK+NFDNVGAGYLALLQVATFKGWMDIMYAAVDSR +EQP++E N+YMYIYF
Sbjct: 1000 GELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYF 1059
Query: 1445 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1504
VIFIIFGSFFTLNLFIGVIIDNFNQQKKK GGQDIFMTEEQKKYYNAMKKLGSKKPQKPI
Sbjct: 1060 VIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPI 1119
Query: 1505 PRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIF 1564
PRPLNK QG +FD VT+QAFD+ IM LICLNMVTMMVETD QS + NIL INL+FV
Sbjct: 1120 PRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAI 1179
Query: 1565 FTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARI 1624
FT EC++K+ ALRHYYFT WNIFDFVVVILSIVG L+DII+KYF SPTLFRVIRLARI
Sbjct: 1180 FTGECIVKLAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARI 1239
Query: 1625 GRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDD 1684
GRILRLI+GAKGIRTLLFALMMSLPALFNIGLLLFLVMFI+SIFGM+NFAYVK EAGIDD
Sbjct: 1240 GRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDD 1299
Query: 1685 MFNFETFGNSMICLFQITTSAGWDGLLLPILNR-PPDCSLDKEHPGS-GFKGDCGNPSVG 1742
MFNF+TF NSM+CLFQITTSAGWDGLL PILN PP C D P S G +GDCG+P+VG
Sbjct: 1300 MFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYC--DPTLPNSNGSRGDCGSPAVG 1357
Query: 1743 IFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQF 1802
I FF +YIIISFLIVVNMYIAIILENFSVATEES +PLSEDDF+ FYEIWEKFDP+ATQF
Sbjct: 1358 ILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQF 1417
Query: 1803 IEY 1805
IEY
Sbjct: 1418 IEY 1420
Score = 679 bits (1751), Expect = 0.0
Identities = 382/670 (57%), Positives = 462/670 (68%), Gaps = 66/670 (9%)
Query: 3 ARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAG 62
A L P G SF+ FT ESLA IE+R+AE + + S E+ P+P DL+A
Sbjct: 2 ANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQLDLQAS 61
Query: 63 KSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIR 122
K LP +YG+ PQ L+ PLED DP+Y TQKTF+VLN+GKT+FRFSAT ALY+LSPF+ IR
Sbjct: 62 KKLPDLYGNPPQELIGEPLEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPIR 121
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSKNVEYTFTGIYTFESLVKIIARGF 182
R A+KIL+HS+F+M+IMCTILTNCVFM +PP W+K VEYTFT IYTFESLVKI+ARGF
Sbjct: 122 RAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGF 181
Query: 183 CIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVG 242
C+ FTFLRDPWNWLDFSVI+MAY TEFV+LGNVSALRTFRVLRALKTISVI GLKTIVG
Sbjct: 182 CLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTIVG 241
Query: 243 ALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT---KG 299
ALIQSVKKL+DVM+LTVFCLSVFALIGLQLFMGNLR+KCV NF NG+ G
Sbjct: 242 ALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV---RNFTALNGTNGSVEADG 298
Query: 300 FDWEE---YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTF 356
WE Y+++ N+ G + LLCGNSSDAG CPEGY+C+KAG NP++GYTSFD+F
Sbjct: 299 LVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSF 358
Query: 357 SWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEE 416
+WAFLALFRLMTQD WE LYQ TLR+AGK YMIFF+LVIF+GSFYLVNLILAVVAMAYEE
Sbjct: 359 AWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEE 418
Query: 417 QNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476
QNQAT+ E E+KE F+ +E LKK+ E A TVS RS
Sbjct: 419 QNQATIAETEEKEKRFQEAMEMLKKEHE----ALTIRGVDTVS---------------RS 459
Query: 477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRI 536
S E+S L+ ++ ERR++R+KR +S G E+ +++ KS+SEDG R
Sbjct: 460 SLEMSPLAPVNSHERRSKRRKR----MSSGTEECGEDRLPKSDSEDGPR----------- 504
Query: 537 GRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEG 596
++ + SL + +S+ SIF+FR RD GSE +FADDE+ST ESE
Sbjct: 505 ----AMNHLSLTRGLSRTSMKPRSSRGSIFTFRR----RDLGSEADFADDENSTAGESES 556
Query: 597 RRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG--- 653
SL +P RR+S G S G+ + P K+NSTVDCNGVVSL+G
Sbjct: 557 HHTSLLVPWPL--RRTSAQGQP--SPGTSA----PGHALHGKKNSTVDCNGVVSLLGAGD 608
Query: 654 ----GPGSHI 659
PGSH+
Sbjct: 609 PEATSPGSHL 618
Score = 92.0 bits (227), Expect = 5e-18
Identities = 73/278 (26%), Positives = 133/278 (47%), Gaps = 40/278 (14%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMD 808
IV D+ I I LN + M +E +P+ ++LA NL+F IFT E +KL A+
Sbjct: 1133 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL- 1191
Query: 809 PYYYFQEGWNIFDGFIVSLSLMELSLADV--------EGLSVLRSFRLLRVFKLAKSWPT 860
+YYF WNIFD +V LS++ L+D+ V+R R+ R+ +L +
Sbjct: 1192 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1251
Query: 861 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMH 920
+ L+ + S+ AL N+ L+L +++FI+++ GM F +Y + I+ ++
Sbjct: 1252 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF--AYVKWEAGIDD-----MFNFQ 1304
Query: 921 DFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMC--------------------LIVFMMV 960
F +S L +F++ + + + G C ++ F
Sbjct: 1305 TFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTY 1364
Query: 961 MVIGNLVVLNLFLALLLSSFSADNLAAT----DDDGEM 994
++I L+V+N+++A++L +FS +T +DD +M
Sbjct: 1365 IIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDM 1402
Score = 89.0 bits (219), Expect = 4e-17
Identities = 85/350 (24%), Positives = 156/350 (44%), Gaps = 69/350 (19%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILE 1246
+R+ I+ H+ F I+ IL + +A D +Y + FT I+ E
Sbjct: 120 IRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP--------PPWTKYVEYTFTAIYTFE 171
Query: 1247 MLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALR 1302
L+K A GF F + W WLDF ++ ++A + +LG + +LRT R LR
Sbjct: 172 SLVKILARGFCLHAFTFLRDPWNWLDFSVI------IMAYTTEFVDLGNVSALRTFRVLR 225
Query: 1303 PLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYC----- 1356
L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G H C
Sbjct: 226 ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFT 285
Query: 1357 -FNETS-----------EIRFEIEDVNN----KTECEKLMEGNNTEI-----RWKNVK-- 1393
N T+ + + D N + L+ GN+++ ++ +K
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAG 345
Query: 1394 -------INFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVI 1446
+FD+ +LAL ++ T W R + + IYM I+F++
Sbjct: 346 ENPDHGYTSFDSFAWAFLALFRLMTQDCW---------ERLYQQTLRSAGKIYM-IFFML 395
Query: 1447 FIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEE-QKKYYNAMKKL 1495
I GSF+ +NL + V+ + +Q + I TEE +K++ AM+ L
Sbjct: 396 VIFLGSFYLVNLILAVVAMAYEEQNQ----ATIAETEEKEKRFQEAMEML 441
Score = 82.0 bits (201), Expect = 5e-15
Identities = 66/277 (23%), Positives = 121/277 (43%), Gaps = 66/277 (23%)
Query: 165 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI------MMAYITEFVNLGNVSA 218
FT ++ E L+K +A GF + + W WLDF ++ ++A F +G + +
Sbjct: 855 FTYVFVLEMLLKWVAYGFK----KYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKS 910
Query: 219 LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLR 278
LRT R LR L+ +S G++ +V AL+ ++ + +V+++ + +F+++G+ LF G
Sbjct: 911 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF- 969
Query: 279 NKCVVWPINFNESYLENGTKGFDWEEY--INNKTNFYTVPGMLEPLLCGNSSDAGQCPEG 336
+C+ N T+G Y +NNK+
Sbjct: 970 GRCI------------NQTEGDLPLNYTIVNNKS-------------------------- 991
Query: 337 YQCMKAGRNPNYGYT----SFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG-------- 384
QC +T +FD +LAL ++ T W ++ + + G
Sbjct: 992 -QCESLNLTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1050
Query: 385 -KTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQ 419
YM I+FV+ I GSF+ +NL + V+ + +Q +
Sbjct: 1051 YNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKK 1087
Score = 64.7 bits (156), Expect = 9e-10
Identities = 49/187 (26%), Positives = 91/187 (48%), Gaps = 13/187 (6%)
Query: 724 YKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH 783
++F+ T ++ P+ + V ++V F ++ I I+ N +FMA P P ++
Sbjct: 103 FRFSATNALYVLSPFHPIRRAAVKILVHSLF-NMLIMCTILTNCVFMAQHDPP--PWTKY 159
Query: 784 VLAVGNLVFTGIFTAEMFLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVEG 839
V FT I+T E +K++A + + + ++ WN D F V + D+
Sbjct: 160 V----EYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLD-FSVIIMAYTTEFVDLGN 214
Query: 840 LSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-G 898
+S LR+FR+LR K L ++ + SV L ++ ++ + +FA++G+QLF G
Sbjct: 215 VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274
Query: 899 KSYKECV 905
+CV
Sbjct: 275 NLRHKCV 281
Score = 63.9 bits (154), Expect = 1e-09
Identities = 49/237 (20%), Positives = 102/237 (43%), Gaps = 39/237 (16%)
Query: 784 VLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMEL-----SLADVE 838
+L + +FT +F EM LK +A YF W D IV +SL+ L A++
Sbjct: 847 LLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMG 906
Query: 839 GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFG 898
+ LR+ R LR + + + +++ + ++ ++ N+ LV I IF+++G+ LF
Sbjct: 907 PIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 966
Query: 899 KSYKECVCKINQDCEL------------------------PRWHMHDFFHSFLIVFRVLC 934
+ C+ + D L + + + +L + +V
Sbjct: 967 GKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVGAGYLALLQVAT 1026
Query: 935 GE-WIETMWDCMEVAG---------QAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981
+ W++ M+ ++ G I F++ ++ G+ LNLF+ +++ +F+
Sbjct: 1027 FKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFN 1083
Score = 34.7 bits (78), Expect = 0.95
Identities = 18/72 (25%), Positives = 39/72 (54%)
Query: 922 FFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981
F +FL +FR++ + E ++ + + +I FM+V+ +G+ ++NL LA++ ++
Sbjct: 358 FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417
Query: 982 ADNLAATDDDGE 993
N A + E
Sbjct: 418 EQNQATIAETEE 429
>gi|192807298 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform c [Homo sapiens]
Length = 2137
Score = 412 bits (1060), Expect = e-114
Identities = 328/1161 (28%), Positives = 562/1161 (48%), Gaps = 173/1161 (14%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + + LNTL ++ EH+ + + N V +FT EM +K+ ++ YF +N
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V + E L ++E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F + L VF++L
Sbjct: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLA 986
GE W M+D + +G +C I F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVC-IYFIILFICGNYILLNVFLAI-----AVDNLA 756
Query: 987 ATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIA 1046
D E N Q+E E K ++ K++
Sbjct: 757 ----DAESLNT--------------------------AQKEEAEEKERKKIARKESL--- 783
Query: 1047 NHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFE 1106
+ +KN + I +S K ID D+ + + + VGE + E
Sbjct: 784 -----------ENKKNNKPEVNQIANSDNKVTID-DYREEDEDKDPYPPCDVPVGEEEEE 831
Query: 1107 NLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCV 1166
E+ P G + + S +++K ++ +P EG
Sbjct: 832 ----EEEDEPEVPAGPRPR-------RISELNMKEKIAPIP---------------EG-- 863
Query: 1167 QRFKCCQVNIEEGLGKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDI 1220
+++IL KT C ++ H+ F I+ I+LSS ALA ED
Sbjct: 864 ---------------SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED- 907
Query: 1221 YIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSL 1276
I TIL Y D FT IF +E+LLK T +G F N + LD L+V VSL
Sbjct: 908 PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL 967
Query: 1277 VSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 1336
VS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++V +
Sbjct: 968 VSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024
Query: 1337 FWLIFSIMGVNLFAGKYHYCFNETSE---------IRFEIEDVNNKTECEKLMEGNNTEI 1387
+F+ +GV LF GK++ C +E I ++ DV++ E++
Sbjct: 1025 LQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERI-------- 1076
Query: 1388 RWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIF 1447
W+N NFDNV + +AL V+TF+GW ++Y A+DS + P Y + + I+F+I+
Sbjct: 1077 -WQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1135
Query: 1448 IIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR 1506
II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +P+ R
Sbjct: 1136 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRR 1187
Query: 1507 --PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIF 1564
P N Q + V F+ ++ +LI LN + + ++ QSK + + +N+VF
Sbjct: 1188 YIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGV 1247
Query: 1565 FTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLAR 1623
FT E VLK+ A + YF+ WN FD ++VI SI+ + L++ + RL R
Sbjct: 1248 FTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFR 1307
Query: 1624 IGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV--KHEAG 1681
+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+++ GM F V +
Sbjct: 1308 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQ 1367
Query: 1682 IDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKE---HPGSGFKGDCGN 1738
I+ NF+TF +++ LF+ T W ++L L P D E +PG + CG+
Sbjct: 1368 INRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL---PGKLCDPESDYNPGEEY--TCGS 1422
Query: 1739 PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPD 1798
+ I +F+S+ ++ +++N+++A+I++NF T + + L + F IW ++DP+
Sbjct: 1423 -NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWSEYDPE 1480
Query: 1799 ATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFTK 1853
A I++ + ++ PL K P+ + L+AM++P+ S + LFA +
Sbjct: 1481 AKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVR 1540
Query: 1854 RVLGDSGELDILRQQMEERFV 1874
L E ++ + E R V
Sbjct: 1541 TALKIKTEGNLEQANEELRAV 1561
Score = 159 bits (401), Expect = 3e-38
Identities = 119/433 (27%), Positives = 201/433 (46%), Gaps = 72/433 (16%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL+ LS N IRR I I+ F + I+ I NCV + P P+ N V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAY-------ITEFVNLG 214
EY F I+T E+ +KIIA G + ++R+ WN LDF ++++ +T+ G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 215 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 264
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 265 FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLC 324
+A+IGL+LF+G + C F +S + +P C
Sbjct: 285 YAIIGLELFIGKMHKTCF-----FADS----------------------DIVAEEDPAPC 317
Query: 325 GNSSDAGQCP-EGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRA 382
S + QC G +C PN G T+FD F++A L +F+ +T + W + LY +
Sbjct: 318 AFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAM 377
Query: 383 AGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKA 434
+ ++FV ++ GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 378 GFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKG 437
Query: 435 MLEQL--------KKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS-SSEISKLSS 485
L+ + + ++E + TS T +++ E G G R + + S
Sbjct: 438 YLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAIS 497
Query: 486 KSAKERRNRRKKR 498
KS RR RR R
Sbjct: 498 KSKLSRRWRRWNR 510
Score = 142 bits (358), Expect = 3e-33
Identities = 109/334 (32%), Positives = 161/334 (48%), Gaps = 52/334 (15%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGA------- 1291
F +E LK AYG + + N W LDF+IV V L S+I L G
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1292 ----IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1347
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1348 LFAGKYH-YCFNETSEIRFEIED-------------VNNKTECEKLMEGNNTEIRWKNVK 1393
LF GK H CF S+I E ED N TEC G N I
Sbjct: 292 LFIGKMHKTCFFADSDIVAE-EDPAPCAFSGNGRQCTANGTECRSGWVGPNGGI------ 344
Query: 1394 INFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSF 1453
NFDN L + Q T +GW D++Y D+ E P ++YFV +IFGSF
Sbjct: 345 TNFDNFAFAMLTVFQCITMEGWTDVLYWMNDA-MGFELP--------WVYFVSLVIFGSF 395
Query: 1454 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
F LNL +GV+ F+++++K + F +K+
Sbjct: 396 FVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 429
Score = 132 bits (331), Expect = 4e-30
Identities = 87/295 (29%), Positives = 151/295 (51%), Gaps = 34/295 (11%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K +PY K +VN PF + + + I+LNTL +
Sbjct: 1167 ELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN---SSPF-EYMMFVLIMLNTLCL 1222
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F + + N+VFTG+FT EM LK+IA P YF + WN FD IV S++
Sbjct: 1223 AMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSII 1282
Query: 831 ELSLADVE--------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 882
+++L++ + ++ R FR++R+ KL + L+ S AL + L++
Sbjct: 1283 DVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1342
Query: 883 AIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE-WIETM 941
A++ FI+AV+GMQ+FGK +IN++ + F + L++FR GE W E M
Sbjct: 1343 AMLFFIYAVIGMQMFGKVAMRDNNQINRNN-----NFQTFPQAVLLLFRCATGEAWQEIM 1397
Query: 942 WDCME----------------VAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSF 980
C+ G ++ F+ ++ +++NLF+A+++ +F
Sbjct: 1398 LACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNF 1452
Score = 103 bits (258), Expect = 1e-21
Identities = 92/397 (23%), Positives = 163/397 (41%), Gaps = 55/397 (13%)
Query: 1111 EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFK 1170
ED+ E++ EG ++ +TS T + E E GC
Sbjct: 446 EDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN------------RGCCGSL- 492
Query: 1171 CCQVNIEEGLGKSW--W--ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRK 1226
CQ + L + W W R+ C V+ F +I ++ L++ ++ E + Q
Sbjct: 493 -CQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPD 549
Query: 1227 TIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY 1286
+ I + A+KV +F EML+K + G +F + + D +V + I L
Sbjct: 550 WLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEI 609
Query: 1287 SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1346
I R +R LR + + + +V +L+ ++ SI ++LL+ +F +IFS++G+
Sbjct: 610 MSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGM 669
Query: 1347 NLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLAL 1406
LF GK++ F+ET R FDN L +
Sbjct: 670 QLFGGKFN--FDETQTKRS-----------------------------TFDNFPQALLTV 698
Query: 1407 LQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDN 1466
Q+ T + W +MY + + + + IYF+I I G++ LN+F+ + +DN
Sbjct: 699 FQILTGEDWNAVMYDGIMAYGGPSS----SGMIVCIYFIILFICGNYILLNVFLAIAVDN 754
Query: 1467 FNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
+ Q E+++K + L +KK KP
Sbjct: 755 LADAESLNTAQKEEAEEKERKKIARKESLENKKNNKP 791
Score = 95.5 bits (236), Expect = 5e-19
Identities = 94/403 (23%), Positives = 170/403 (42%), Gaps = 63/403 (15%)
Query: 44 HREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTL 103
+RE+DED P P D+ G+ D P+ P + LN + +
Sbjct: 808 YREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV----------PAGPRPRRISELNMKEKI 857
Query: 104 FRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP---PDWSKN 160
A +ILS N IR K++ H +F+ +I+ I+ + + +P +
Sbjct: 858 APIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNT 917
Query: 161 V----EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNV 216
+ +Y FT I+T E L+K+ G + F R+ +N LD V+ ++ ++ + +
Sbjct: 918 ILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAI 977
Query: 217 SA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
S LR RVLR L+ I+ GLK +V + +++ + ++MI+T +FA IG+QLF
Sbjct: 978 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1037
Query: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
G N E +G +I K P + E
Sbjct: 1038 KGKFYRCTDEAKSNPEE------CRGL----FILYKDGDVDSPVVRE------------- 1074
Query: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKT------- 386
+ +N ++ +FD A +ALF + T + W L + + G+
Sbjct: 1075 -------RIWQNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNH 1124
Query: 387 ---YMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE 426
IFF++ I + +F+++N+ + V + ++EQ + + E
Sbjct: 1125 RVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCE 1167
Score = 85.1 bits (209), Expect = 6e-16
Identities = 68/270 (25%), Positives = 126/270 (46%), Gaps = 21/270 (7%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F ++++L+ LN +T+ E Q + I N V + FTCE ++KM++L
Sbjct: 520 VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL 579
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I L +E +SP V R R+ RI ++ + +
Sbjct: 580 QAYFVSLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF-AYVKHEAGIDDMFNFETFGNSMI 1696
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + F+ F +++
Sbjct: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALL 696
Query: 1697 CLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLI 1756
+FQI T W+ ++ + + G + + +F+ I I
Sbjct: 697 TVFQILTGEDWNAVMYDGI--------------MAYGGPSSSGMIVCIYFIILFICGNYI 742
Query: 1757 VVNMYIAIILENFSVATEESADPLSEDDFE 1786
++N+++AI ++N +A ES + +++ E
Sbjct: 743 LLNVFLAIAVDN--LADAESLNTAQKEEAE 770
Score = 81.3 bits (199), Expect = 9e-15
Identities = 73/295 (24%), Positives = 131/295 (44%), Gaps = 59/295 (20%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPM----TPQFEHVLAVGNLVFTGIFTAEMF 801
++++ PF D+ I + I N + +A+ + P + H L F IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
Query: 802 LKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLA----DVEG------------LS 841
LK+IA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
Query: 901 YKECV-----------------------CKINQDCELPRW--------HMHDFFHSFLIV 929
+K C C N W + +F + L V
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTV 357
Query: 930 FRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
F+ + E W + ++ + G + + F+ +++ G+ VLNL L +L FS +
Sbjct: 358 FQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412
Score = 79.7 bits (195), Expect = 3e-14
Identities = 83/394 (21%), Positives = 156/394 (39%), Gaps = 85/394 (21%)
Query: 1481 MTEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICL 1534
+++ +++ Y KK G+ +P R L N I+ V + FDI I++ I
Sbjct: 80 LSQRKRQQYAKSKKQGNSSNSRPA-RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFA 138
Query: 1535 NMVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFA---LRH--YYFTIGWN 1586
N V + + + S + L + F+I FT E LK+ A L H Y GWN
Sbjct: 139 NCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWN 198
Query: 1587 IFDFVVVILSIVGMFLADIIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIR 1638
+ DFV+VI+ + + L + ++ + +R R+ R LRL+ G ++
Sbjct: 199 LLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQ 258
Query: 1639 TLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGI---------------- 1682
+L +++ ++ L +I LL+ V+ I++I G+ F H+
Sbjct: 259 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCA 318
Query: 1683 -----------------------DDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
+ NF+ F +M+ +FQ T GW +L
Sbjct: 319 FSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLY------- 371
Query: 1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADP 1779
+ D + +FVS +I V+N+ + ++ FS E++
Sbjct: 372 ------------WMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK-- 417
Query: 1780 LSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ DF+ E ++ + D ++++ A+ D
Sbjct: 418 -ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 449
Score = 63.5 bits (153), Expect = 2e-09
Identities = 92/426 (21%), Positives = 166/426 (38%), Gaps = 97/426 (22%)
Query: 136 MIIMCTILTNCVFMTFSNPPDWSKNVE----YTFTGIYTFESLVKIIARGFCIDGFTFLR 191
+I++ + T + N PDW ++ ++T E LVK+ + G +
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ----AYFV 584
Query: 192 DPWNWLDFSVIMMAYITEFVNLG-------NVSALRTFRVLRALKTISVIPGLKTIVGAL 244
+N D V+ ITE + + +S R R+LR K L +V +L
Sbjct: 585 SLFNRFDCFVVCGG-ITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
Query: 245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEE 304
+ S+K ++ +++L + +F+L+G+QLF G NF+E+ + T FD
Sbjct: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDETQTKRST--FD--- 689
Query: 305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALF 364
NF + +L G +A Y + A P+
Sbjct: 690 ------NFPQALLTVFQILTGEDWNAVM----YDGIMAYGGPS----------------- 722
Query: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVA---MAYEEQNQAT 421
++G I+F+++ G++ L+N+ LA+ E N A
Sbjct: 723 -----------------SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 765
Query: 422 LEEAEQKEAEFKAMLEQLK-KQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEI 480
EEAE+KE + A E L+ K+ + + +A S V+ D EE E+ P +
Sbjct: 766 KEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPV 825
Query: 481 SKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKF 540
++ +++E E E P + SE M+ K +P+ G F
Sbjct: 826 G--------------EEEEEEEEDEPEVPAGPRP--RRISELNMKEKIAPIPE---GSAF 866
Query: 541 SIMNQS 546
I++++
Sbjct: 867 FILSKT 872
Score = 62.4 bits (150), Expect = 4e-09
Identities = 44/181 (24%), Positives = 94/181 (51%), Gaps = 12/181 (6%)
Query: 730 FLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH-VLAVG 788
F++ + +P + +++N + F +L I + I+L++ +A E + F + +L
Sbjct: 867 FILSKTNPIRVGCHKLINHHI---FTNL-ILVFIMLSSAALAAEDPIRSHSFRNTILGYF 922
Query: 789 NLVFTGIFTAEMFLKLIAMDPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSV 842
+ FT IFT E+ LK+ + + + +N+ D +V +SL+ + + + +
Sbjct: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 982
Query: 843 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
LR R+LR + L +++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 983 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1042
Query: 902 K 902
+
Sbjct: 1043 R 1043
Score = 60.8 bits (146), Expect = 1e-08
Identities = 62/262 (23%), Positives = 107/262 (40%), Gaps = 45/262 (17%)
Query: 134 FSMIIMCTILTNCVFMTFSNPP----DWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189
+ M ++ + T C+ M D + FTG++T E ++K+IA F G+
Sbjct: 1209 YMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA--FKPKGY-- 1264
Query: 190 LRDPWNWLDFSVIMMAYI---------TEFVNLGNVSALRTFRVLRALKTISVIPGLKTI 240
D WN D +++ + I +E N +++ R FRV+R +K +S G++T+
Sbjct: 1265 FSDAWNTFDSLIVIGSIIDVALSEADNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTL 1324
Query: 241 VGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGF 300
+ I+S + L V +L ++A+IG+Q+F G
Sbjct: 1325 LWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF----------------------GKVAM 1362
Query: 301 DWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQ-----CPEGYQC-MKAGRNPNYGYTSFD 354
IN NF T P + L + +A Q C G C ++ NP YT
Sbjct: 1363 RDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGS 1422
Query: 355 TFSWAFLALFRLMTQDYWENLY 376
F+ + F ++ NL+
Sbjct: 1423 NFAIVYFISFYMLCAFLIINLF 1444
>gi|192807300 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform b [Homo sapiens]
Length = 2161
Score = 407 bits (1045), Expect = e-113
Identities = 332/1179 (28%), Positives = 566/1179 (48%), Gaps = 194/1179 (16%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + + LNTL ++ EH+ + + N V +FT EM +K+ ++ YF +N
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 588
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V + E L ++E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 589 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 648
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F + L VF++L
Sbjct: 649 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 702
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLA 986
GE W M+D + +G +C I F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 703 TGEDWNAVMYDGIMAYGGPSSSGMIVC-IYFIILFICGNYILLNVFLAI-----AVDNLA 756
Query: 987 ATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIA 1046
D E N Q+E E K ++ K++
Sbjct: 757 ----DAESLNT--------------------------AQKEEAEEKERKKIARKESL--- 783
Query: 1047 NHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFE 1106
+ +KN + I +S K ID D+ + + + VGE + E
Sbjct: 784 -----------ENKKNNKPEVNQIANSDNKVTID-DYREEDEDKDPYPPCDVPVGEEEEE 831
Query: 1107 NLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCV 1166
E+ P G + + S +++K ++ +P EG
Sbjct: 832 ----EEEDEPEVPAGPRPR-------RISELNMKEKIAPIP---------------EG-- 863
Query: 1167 QRFKCCQVNIEEGLGKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDI 1220
+++IL KT C ++ H+ F I+ I+LSS ALA ED
Sbjct: 864 ---------------SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED- 907
Query: 1221 YIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSL 1276
I TIL Y D FT IF +E+LLK T +G F N + LD L+V VSL
Sbjct: 908 PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL 967
Query: 1277 VSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 1336
VS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++V +
Sbjct: 968 VSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1024
Query: 1337 FWLIFSIMGVNLFAGKYHYCFNETSE---------IRFEIEDVNNKTECEKLMEGNNTEI 1387
+F+ +GV LF GK++ C +E I ++ DV++ E++
Sbjct: 1025 LQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERI-------- 1076
Query: 1388 RWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIF 1447
W+N NFDNV + +AL V+TF+GW ++Y A+DS + P Y + + I+F+I+
Sbjct: 1077 -WQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1135
Query: 1448 IIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR 1506
II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +P+ R
Sbjct: 1136 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRR 1187
Query: 1507 --PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIF 1564
P N Q + V F+ ++ +LI LN + + ++ QSK + + +N+VF
Sbjct: 1188 YIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGV 1247
Query: 1565 FTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADI------------------ 1605
FT E VLK+ A + YF+ WN FD ++VI SI+ + L++
Sbjct: 1248 FTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNS 1307
Query: 1606 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIF 1665
E +S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+
Sbjct: 1308 EESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1364
Query: 1666 SIFGMSNFAYV--KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSL 1723
++ GM F V + I+ NF+TF +++ LF+ T W ++L L P
Sbjct: 1365 AVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL---PGKLC 1421
Query: 1724 DKE---HPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPL 1780
D E +PG + CG+ + I +F+S+ ++ +++N+++A+I++NF T + + L
Sbjct: 1422 DPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-IL 1477
Query: 1781 SEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLP 1835
+ F IW ++DP+A I++ + ++ PL K P+ + L+AM++P
Sbjct: 1478 GPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1537
Query: 1836 MVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFV 1874
+ S + LFA + L E ++ + E R V
Sbjct: 1538 LNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAV 1576
Score = 159 bits (401), Expect = 3e-38
Identities = 119/433 (27%), Positives = 201/433 (46%), Gaps = 72/433 (16%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL+ LS N IRR I I+ F + I+ I NCV + P P+ N V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAY-------ITEFVNLG 214
EY F I+T E+ +KIIA G + ++R+ WN LDF ++++ +T+ G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 215 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 264
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 265 FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLC 324
+A+IGL+LF+G + C F +S + +P C
Sbjct: 285 YAIIGLELFIGKMHKTCF-----FADS----------------------DIVAEEDPAPC 317
Query: 325 GNSSDAGQCP-EGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRA 382
S + QC G +C PN G T+FD F++A L +F+ +T + W + LY +
Sbjct: 318 AFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAM 377
Query: 383 AGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKA 434
+ ++FV ++ GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 378 GFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKG 437
Query: 435 MLEQL--------KKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS-SSEISKLSS 485
L+ + + ++E + TS T +++ E G G R + + S
Sbjct: 438 YLDWITQAEDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGENRGCCGSLCQAIS 497
Query: 486 KSAKERRNRRKKR 498
KS RR RR R
Sbjct: 498 KSKLSRRWRRWNR 510
Score = 142 bits (358), Expect = 3e-33
Identities = 109/334 (32%), Positives = 161/334 (48%), Gaps = 52/334 (15%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGA------- 1291
F +E LK AYG + + N W LDF+IV V L S+I L G
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1292 ----IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1347
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1348 LFAGKYH-YCFNETSEIRFEIED-------------VNNKTECEKLMEGNNTEIRWKNVK 1393
LF GK H CF S+I E ED N TEC G N I
Sbjct: 292 LFIGKMHKTCFFADSDIVAE-EDPAPCAFSGNGRQCTANGTECRSGWVGPNGGI------ 344
Query: 1394 INFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSF 1453
NFDN L + Q T +GW D++Y D+ E P ++YFV +IFGSF
Sbjct: 345 TNFDNFAFAMLTVFQCITMEGWTDVLYWMNDA-MGFELP--------WVYFVSLVIFGSF 395
Query: 1454 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
F LNL +GV+ F+++++K + F +K+
Sbjct: 396 FVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 429
Score = 126 bits (316), Expect = 2e-28
Identities = 87/310 (28%), Positives = 151/310 (48%), Gaps = 49/310 (15%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K +PY K +VN PF + + + I+LNTL +
Sbjct: 1167 ELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN---SSPF-EYMMFVLIMLNTLCL 1222
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F + + N+VFTG+FT EM LK+IA P YF + WN FD IV S++
Sbjct: 1223 AMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSII 1282
Query: 831 ELSLADVE-----------------------GLSVLRSFRLLRVFKLAKSWPTLNMLIKI 867
+++L++ + ++ R FR++R+ KL + L+
Sbjct: 1283 DVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT 1342
Query: 868 IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFL 927
S AL + L++A++ FI+AV+GMQ+FGK +IN++ + F + L
Sbjct: 1343 FIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN-----NFQTFPQAVL 1397
Query: 928 IVFRVLCGE-WIETMWDCME----------------VAGQAMCLIVFMMVMVIGNLVVLN 970
++FR GE W E M C+ G ++ F+ ++ +++N
Sbjct: 1398 LLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIIN 1457
Query: 971 LFLALLLSSF 980
LF+A+++ +F
Sbjct: 1458 LFVAVIMDNF 1467
Score = 103 bits (258), Expect = 1e-21
Identities = 92/397 (23%), Positives = 163/397 (41%), Gaps = 55/397 (13%)
Query: 1111 EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFK 1170
ED+ E++ EG ++ +TS T + E E GC
Sbjct: 446 EDIDPENEEEGGEEGKRNTSMPTSETESVNTENVSGEGEN------------RGCCGSL- 492
Query: 1171 CCQVNIEEGLGKSW--W--ILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRK 1226
CQ + L + W W R+ C V+ F +I ++ L++ ++ E + Q
Sbjct: 493 -CQAISKSKLSRRWRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPD 549
Query: 1227 TIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGY 1286
+ I + A+KV +F EML+K + G +F + + D +V + I L
Sbjct: 550 WLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEI 609
Query: 1287 SELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGV 1346
I R +R LR + + + +V +L+ ++ SI ++LL+ +F +IFS++G+
Sbjct: 610 MSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGM 669
Query: 1347 NLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLAL 1406
LF GK++ F+ET R FDN L +
Sbjct: 670 QLFGGKFN--FDETQTKRS-----------------------------TFDNFPQALLTV 698
Query: 1407 LQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDN 1466
Q+ T + W +MY + + + + IYF+I I G++ LN+F+ + +DN
Sbjct: 699 FQILTGEDWNAVMYDGIMAYGGPSS----SGMIVCIYFIILFICGNYILLNVFLAIAVDN 754
Query: 1467 FNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
+ Q E+++K + L +KK KP
Sbjct: 755 LADAESLNTAQKEEAEEKERKKIARKESLENKKNNKP 791
Score = 95.5 bits (236), Expect = 5e-19
Identities = 94/403 (23%), Positives = 170/403 (42%), Gaps = 63/403 (15%)
Query: 44 HREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTL 103
+RE+DED P P D+ G+ D P+ P + LN + +
Sbjct: 808 YREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV----------PAGPRPRRISELNMKEKI 857
Query: 104 FRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP---PDWSKN 160
A +ILS N IR K++ H +F+ +I+ I+ + + +P +
Sbjct: 858 APIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNT 917
Query: 161 V----EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNV 216
+ +Y FT I+T E L+K+ G + F R+ +N LD V+ ++ ++ + +
Sbjct: 918 ILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAI 977
Query: 217 SA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
S LR RVLR L+ I+ GLK +V + +++ + ++MI+T +FA IG+QLF
Sbjct: 978 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1037
Query: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
G N E +G +I K P + E
Sbjct: 1038 KGKFYRCTDEAKSNPEE------CRGL----FILYKDGDVDSPVVRE------------- 1074
Query: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKT------- 386
+ +N ++ +FD A +ALF + T + W L + + G+
Sbjct: 1075 -------RIWQNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNH 1124
Query: 387 ---YMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE 426
IFF++ I + +F+++N+ + V + ++EQ + + E
Sbjct: 1125 RVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCE 1167
Score = 85.1 bits (209), Expect = 6e-16
Identities = 68/270 (25%), Positives = 126/270 (46%), Gaps = 21/270 (7%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F ++++L+ LN +T+ E Q + I N V + FTCE ++KM++L
Sbjct: 520 VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL 579
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I L +E +SP V R R+ RI ++ + +
Sbjct: 580 QAYFVSLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 636
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF-AYVKHEAGIDDMFNFETFGNSMI 1696
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + F+ F +++
Sbjct: 637 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALL 696
Query: 1697 CLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLI 1756
+FQI T W+ ++ + + G + + +F+ I I
Sbjct: 697 TVFQILTGEDWNAVMYDGI--------------MAYGGPSSSGMIVCIYFIILFICGNYI 742
Query: 1757 VVNMYIAIILENFSVATEESADPLSEDDFE 1786
++N+++AI ++N +A ES + +++ E
Sbjct: 743 LLNVFLAIAVDN--LADAESLNTAQKEEAE 770
Score = 81.3 bits (199), Expect = 9e-15
Identities = 73/295 (24%), Positives = 131/295 (44%), Gaps = 59/295 (20%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPM----TPQFEHVLAVGNLVFTGIFTAEMF 801
++++ PF D+ I + I N + +A+ + P + H L F IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
Query: 802 LKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLA----DVEG------------LS 841
LK+IA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
Query: 901 YKECV-----------------------CKINQDCELPRW--------HMHDFFHSFLIV 929
+K C C N W + +F + L V
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTV 357
Query: 930 FRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
F+ + E W + ++ + G + + F+ +++ G+ VLNL L +L FS +
Sbjct: 358 FQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKE 412
Score = 79.7 bits (195), Expect = 3e-14
Identities = 83/394 (21%), Positives = 156/394 (39%), Gaps = 85/394 (21%)
Query: 1481 MTEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICL 1534
+++ +++ Y KK G+ +P R L N I+ V + FDI I++ I
Sbjct: 80 LSQRKRQQYAKSKKQGNSSNSRPA-RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFA 138
Query: 1535 NMVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFA---LRH--YYFTIGWN 1586
N V + + + S + L + F+I FT E LK+ A L H Y GWN
Sbjct: 139 NCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWN 198
Query: 1587 IFDFVVVILSIVGMFLADIIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIR 1638
+ DFV+VI+ + + L + ++ + +R R+ R LRL+ G ++
Sbjct: 199 LLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQ 258
Query: 1639 TLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGI---------------- 1682
+L +++ ++ L +I LL+ V+ I++I G+ F H+
Sbjct: 259 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCA 318
Query: 1683 -----------------------DDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
+ NF+ F +M+ +FQ T GW +L
Sbjct: 319 FSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLY------- 371
Query: 1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADP 1779
+ D + +FVS +I V+N+ + ++ FS E++
Sbjct: 372 ------------WMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK-- 417
Query: 1780 LSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ DF+ E ++ + D ++++ A+ D
Sbjct: 418 -ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 449
Score = 63.5 bits (153), Expect = 2e-09
Identities = 92/426 (21%), Positives = 166/426 (38%), Gaps = 97/426 (22%)
Query: 136 MIIMCTILTNCVFMTFSNPPDWSKNVE----YTFTGIYTFESLVKIIARGFCIDGFTFLR 191
+I++ + T + N PDW ++ ++T E LVK+ + G +
Sbjct: 529 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ----AYFV 584
Query: 192 DPWNWLDFSVIMMAYITEFVNLG-------NVSALRTFRVLRALKTISVIPGLKTIVGAL 244
+N D V+ ITE + + +S R R+LR K L +V +L
Sbjct: 585 SLFNRFDCFVVCGG-ITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 643
Query: 245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEE 304
+ S+K ++ +++L + +F+L+G+QLF G NF+E+ + T FD
Sbjct: 644 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDETQTKRST--FD--- 689
Query: 305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALF 364
NF + +L G +A Y + A P+
Sbjct: 690 ------NFPQALLTVFQILTGEDWNAVM----YDGIMAYGGPS----------------- 722
Query: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVA---MAYEEQNQAT 421
++G I+F+++ G++ L+N+ LA+ E N A
Sbjct: 723 -----------------SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 765
Query: 422 LEEAEQKEAEFKAMLEQLK-KQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEI 480
EEAE+KE + A E L+ K+ + + +A S V+ D EE E+ P +
Sbjct: 766 KEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPV 825
Query: 481 SKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKF 540
++ +++E E E P + SE M+ K +P+ G F
Sbjct: 826 G--------------EEEEEEEEDEPEVPAGPRP--RRISELNMKEKIAPIPE---GSAF 866
Query: 541 SIMNQS 546
I++++
Sbjct: 867 FILSKT 872
Score = 62.4 bits (150), Expect = 4e-09
Identities = 44/181 (24%), Positives = 94/181 (51%), Gaps = 12/181 (6%)
Query: 730 FLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH-VLAVG 788
F++ + +P + +++N + F +L I + I+L++ +A E + F + +L
Sbjct: 867 FILSKTNPIRVGCHKLINHHI---FTNL-ILVFIMLSSAALAAEDPIRSHSFRNTILGYF 922
Query: 789 NLVFTGIFTAEMFLKLIAMDPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSV 842
+ FT IFT E+ LK+ + + + +N+ D +V +SL+ + + + +
Sbjct: 923 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 982
Query: 843 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
LR R+LR + L +++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 983 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1042
Query: 902 K 902
+
Sbjct: 1043 R 1043
Score = 55.5 bits (132), Expect = 5e-07
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 60/277 (21%)
Query: 134 FSMIIMCTILTNCVFMTFSNPP----DWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189
+ M ++ + T C+ M D + FTG++T E ++K+IA F G+
Sbjct: 1209 YMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA--FKPKGY-- 1264
Query: 190 LRDPWNWLDFSVIMMAYI---------TEFVNL-------GN--------VSALRTFRVL 225
D WN D +++ + I TE N+ GN ++ R FRV+
Sbjct: 1265 FSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVM 1324
Query: 226 RALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP 285
R +K +S G++T++ I+S + L V +L ++A+IG+Q+F
Sbjct: 1325 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------------ 1372
Query: 286 INFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQ-----CPEGYQC- 339
G IN NF T P + L + +A Q C G C
Sbjct: 1373 ----------GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCD 1422
Query: 340 MKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLY 376
++ NP YT F+ + F ++ NL+
Sbjct: 1423 PESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLF 1459
>gi|4502527 calcium channel, voltage-dependent, L type, alpha 1D
subunit isoform a [Homo sapiens]
Length = 2181
Score = 407 bits (1045), Expect = e-113
Identities = 332/1179 (28%), Positives = 566/1179 (48%), Gaps = 194/1179 (16%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + + LNTL ++ EH+ + + N V +FT EM +K+ ++ YF +N
Sbjct: 549 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLFN 608
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V + E L ++E G+SV R RLLR+FK+ + W +L+ L+ + NS+
Sbjct: 609 RFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMK 668
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F + L VF++L
Sbjct: 669 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDETQTKRSTFDNFPQALLTVFQIL 722
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLA 986
GE W M+D + +G +C I F+++ + GN ++LN+FLA+ + DNLA
Sbjct: 723 TGEDWNAVMYDGIMAYGGPSSSGMIVC-IYFIILFICGNYILLNVFLAI-----AVDNLA 776
Query: 987 ATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANCIA 1046
D E N Q+E E K ++ K++
Sbjct: 777 ----DAESLNT--------------------------AQKEEAEEKERKKIARKESL--- 803
Query: 1047 NHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFE 1106
+ +KN + I +S K ID D+ + + + VGE + E
Sbjct: 804 -----------ENKKNNKPEVNQIANSDNKVTID-DYREEDEDKDPYPPCDVPVGEEEEE 851
Query: 1107 NLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCV 1166
E+ P G + + S +++K ++ +P EG
Sbjct: 852 ----EEEDEPEVPAGPRPR-------RISELNMKEKIAPIP---------------EG-- 883
Query: 1167 QRFKCCQVNIEEGLGKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDI 1220
+++IL KT C ++ H+ F I+ I+LSS ALA ED
Sbjct: 884 ---------------SAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAED- 927
Query: 1221 YIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSL 1276
I TIL Y D FT IF +E+LLK T +G F N + LD L+V VSL
Sbjct: 928 PIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSL 987
Query: 1277 VSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 1336
VS + S + +K LR LR LRPLRA++R +G++ VV + AI +I N+++V +
Sbjct: 988 VSF---GIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTL 1044
Query: 1337 FWLIFSIMGVNLFAGKYHYCFNETSE---------IRFEIEDVNNKTECEKLMEGNNTEI 1387
+F+ +GV LF GK++ C +E I ++ DV++ E++
Sbjct: 1045 LQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERI-------- 1096
Query: 1388 RWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIF 1447
W+N NFDNV + +AL V+TF+GW ++Y A+DS + P Y + + I+F+I+
Sbjct: 1097 -WQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIY 1155
Query: 1448 IIFGSFFTLNLFIGVIIDNFNQQ-KKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPR 1506
II +FF +N+F+G +I F +Q +K++ ++ + Q Y A+K +P+ R
Sbjct: 1156 IIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEY-ALK-------ARPLRR 1207
Query: 1507 --PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIF 1564
P N Q + V F+ ++ +LI LN + + ++ QSK + + +N+VF
Sbjct: 1208 YIPKNPYQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGV 1267
Query: 1565 FTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADI------------------ 1605
FT E VLK+ A + YF+ WN FD ++VI SI+ + L++
Sbjct: 1268 FTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNS 1327
Query: 1606 IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIF 1665
E +S T F RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+
Sbjct: 1328 EESNRISITFF---RLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIY 1384
Query: 1666 SIFGMSNFAYV--KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSL 1723
++ GM F V + I+ NF+TF +++ LF+ T W ++L L P
Sbjct: 1385 AVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL---PGKLC 1441
Query: 1724 DKE---HPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPL 1780
D E +PG + CG+ + I +F+S+ ++ +++N+++A+I++NF T + + L
Sbjct: 1442 DPESDYNPGEEY--TCGS-NFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-IL 1497
Query: 1781 SEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLP 1835
+ F IW ++DP+A I++ + ++ PL K P+ + L+AM++P
Sbjct: 1498 GPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMP 1557
Query: 1836 MVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFV 1874
+ S + LFA + L E ++ + E R V
Sbjct: 1558 LNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAV 1596
Score = 154 bits (390), Expect = 6e-37
Identities = 109/388 (28%), Positives = 188/388 (48%), Gaps = 60/388 (15%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL+ LS N IRR I I+ F + I+ I NCV + P P+ N V
Sbjct: 105 ALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNSTNHNLEKV 164
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAY-------ITEFVNLG 214
EY F I+T E+ +KIIA G + ++R+ WN LDF ++++ +T+ G
Sbjct: 165 EYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGG 224
Query: 215 N----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 264
N V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + +
Sbjct: 225 NHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284
Query: 265 FALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLC 324
+A+IGL+LF+G + C F +S + +P C
Sbjct: 285 YAIIGLELFIGKMHKTCF-----FADS----------------------DIVAEEDPAPC 317
Query: 325 GNSSDAGQCP-EGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAA 383
S + QC G +C PN G T+FD F++A L +F+ +T + W ++ A
Sbjct: 318 AFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAI 377
Query: 384 GKTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQ 442
G + ++FV +I +GSF+++NL+L V++ + ++ E + +F+ + E+ + +
Sbjct: 378 GWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE-----REKAKARGDFQKLREKQQLE 432
Query: 443 QEEAQAAAMATSAGTVSEDAIEEEGEEG 470
++ T A + + EE GEEG
Sbjct: 433 EDLKGYLDWITQAEDIDPENEEEGGEEG 460
Score = 140 bits (354), Expect = 9e-33
Identities = 107/334 (32%), Positives = 160/334 (47%), Gaps = 52/334 (15%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE F+ FI+ I + ALA IYI + + LE + F I
Sbjct: 115 IRRACISIVEWKPFDIFILLAIFANCVALA---IYIPFPEDDSNSTNHNLEKVEYAFLII 171
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGA------- 1291
F +E LK AYG + + N W LDF+IV V L S+I L G
Sbjct: 172 FTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKS 231
Query: 1292 ----IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVN 1347
+K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+
Sbjct: 232 GGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLE 291
Query: 1348 LFAGKYH-YCFNETSEIRFEIED-------------VNNKTECEKLMEGNNTEIRWKNVK 1393
LF GK H CF S+I E ED N TEC G N I
Sbjct: 292 LFIGKMHKTCFFADSDIVAE-EDPAPCAFSGNGRQCTANGTECRSGWVGPNGGI------ 344
Query: 1394 INFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSF 1453
NFDN L + Q T +GW D++Y D+ + + ++YFV II GSF
Sbjct: 345 TNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWE---------WPWVYFVSLIILGSF 395
Query: 1454 FTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
F LNL +GV+ F+++++K + F +K+
Sbjct: 396 FVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 429
Score = 126 bits (316), Expect = 2e-28
Identities = 87/310 (28%), Positives = 151/310 (48%), Gaps = 49/310 (15%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K +PY K +VN PF + + + I+LNTL +
Sbjct: 1187 ELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVN---SSPF-EYMMFVLIMLNTLCL 1242
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F + + N+VFTG+FT EM LK+IA P YF + WN FD IV S++
Sbjct: 1243 AMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSLIVIGSII 1302
Query: 831 ELSLADVE-----------------------GLSVLRSFRLLRVFKLAKSWPTLNMLIKI 867
+++L++ + ++ R FR++R+ KL + L+
Sbjct: 1303 DVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWT 1362
Query: 868 IGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFL 927
S AL + L++A++ FI+AV+GMQ+FGK +IN++ + F + L
Sbjct: 1363 FIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAMRDNNQINRNN-----NFQTFPQAVL 1417
Query: 928 IVFRVLCGE-WIETMWDCME----------------VAGQAMCLIVFMMVMVIGNLVVLN 970
++FR GE W E M C+ G ++ F+ ++ +++N
Sbjct: 1418 LLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIIN 1477
Query: 971 LFLALLLSSF 980
LF+A+++ +F
Sbjct: 1478 LFVAVIMDNF 1487
Score = 97.1 bits (240), Expect = 2e-19
Identities = 75/316 (23%), Positives = 137/316 (43%), Gaps = 37/316 (11%)
Query: 1188 RKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEM 1247
R+ C V+ F +I ++ L++ ++ E + Q + I + A+KV +F EM
Sbjct: 533 RRRCRAAVKSVTFYWLVIVLVFLNTLTISSE--HYNQPDWLTQIQDIANKVLLALFTCEM 590
Query: 1248 LLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRAL 1307
L+K + G +F + + D +V + I L I R +R LR +
Sbjct: 591 LVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVT 650
Query: 1308 SRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEI 1367
+ + +V +L+ ++ SI ++LL+ +F +IFS++G+ LF GK++ F+ET R
Sbjct: 651 RHWTSLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFN--FDETQTKRS-- 706
Query: 1368 EDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRK 1427
FDN L + Q+ T + W +MY + +
Sbjct: 707 ---------------------------TFDNFPQALLTVFQILTGEDWNAVMYDGIMAYG 739
Query: 1428 PDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
+ + IYF+I I G++ LN+F+ + +DN + Q E+++K
Sbjct: 740 GPSS----SGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERK 795
Query: 1488 YYNAMKKLGSKKPQKP 1503
+ L +KK KP
Sbjct: 796 KIARKESLENKKNNKP 811
Score = 95.5 bits (236), Expect = 5e-19
Identities = 94/403 (23%), Positives = 170/403 (42%), Gaps = 63/403 (15%)
Query: 44 HREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTL 103
+RE+DED P P D+ G+ D P+ P + LN + +
Sbjct: 828 YREEDEDKDPYPPCDVPVGEEEEEEEEDEPEV----------PAGPRPRRISELNMKEKI 877
Query: 104 FRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP---PDWSKN 160
A +ILS N IR K++ H +F+ +I+ I+ + + +P +
Sbjct: 878 APIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALAAEDPIRSHSFRNT 937
Query: 161 V----EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGNV 216
+ +Y FT I+T E L+K+ G + F R+ +N LD V+ ++ ++ + +
Sbjct: 938 ILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAI 997
Query: 217 SA---LRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
S LR RVLR L+ I+ GLK +V + +++ + ++MI+T +FA IG+QLF
Sbjct: 998 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLF 1057
Query: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
G N E +G +I K P + E
Sbjct: 1058 KGKFYRCTDEAKSNPEE------CRGL----FILYKDGDVDSPVVRE------------- 1094
Query: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKT------- 386
+ +N ++ +FD A +ALF + T + W L + + G+
Sbjct: 1095 -------RIWQNSDF---NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNH 1144
Query: 387 ---YMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE 426
IFF++ I + +F+++N+ + V + ++EQ + + E
Sbjct: 1145 RVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCE 1187
Score = 85.1 bits (209), Expect = 6e-16
Identities = 68/270 (25%), Positives = 126/270 (46%), Gaps = 21/270 (7%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F ++++L+ LN +T+ E Q + I N V + FTCE ++KM++L
Sbjct: 540 VKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGL 599
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I L +E +SP V R R+ RI ++ + +
Sbjct: 600 QAYFVSLFNRFDCFVVCGGITETIL---VELEIMSPLGISVFRCVRLLRIFKVTRHWTSL 656
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF-AYVKHEAGIDDMFNFETFGNSMI 1696
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + F+ F +++
Sbjct: 657 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALL 716
Query: 1697 CLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLI 1756
+FQI T W+ ++ + + G + + +F+ I I
Sbjct: 717 TVFQILTGEDWNAVMYDGI--------------MAYGGPSSSGMIVCIYFIILFICGNYI 762
Query: 1757 VVNMYIAIILENFSVATEESADPLSEDDFE 1786
++N+++AI ++N +A ES + +++ E
Sbjct: 763 LLNVFLAIAVDN--LADAESLNTAQKEEAE 790
Score = 81.3 bits (199), Expect = 9e-15
Identities = 73/295 (24%), Positives = 131/295 (44%), Gaps = 59/295 (20%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPM----TPQFEHVLAVGNLVFTGIFTAEMF 801
++++ PF D+ I + I N + +A+ + P + H L F IFT E F
Sbjct: 120 ISIVEWKPF-DIFILLAIFANCVALAI-YIPFPEDDSNSTNHNLEKVEYAFLIIFTVETF 177
Query: 802 LKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLA----DVEG------------LS 841
LK+IA + P Y + GWN+ D IV + L + L + EG +
Sbjct: 178 LKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVK 237
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 238 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKM 297
Query: 901 YKECV-----------------------CKINQDCELPRW--------HMHDFFHSFLIV 929
+K C C N W + +F + L V
Sbjct: 298 HKTCFFADSDIVAEEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTV 357
Query: 930 FRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
F+ + E W + ++ + G + F+ ++++G+ VLNL L +L FS +
Sbjct: 358 FQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE 412
Score = 80.1 bits (196), Expect = 2e-14
Identities = 85/394 (21%), Positives = 160/394 (40%), Gaps = 85/394 (21%)
Query: 1481 MTEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICL 1534
+++ +++ Y KK G+ +P R L N I+ V + FDI I++ I
Sbjct: 80 LSQRKRQQYAKSKKQGNSSNSRPA-RALFCLSLNNPIRRACISIVEWKPFDIFILLAIFA 138
Query: 1535 NMVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFA---LRH--YYFTIGWN 1586
N V + + + S + L + F+I FT E LK+ A L H Y GWN
Sbjct: 139 NCVALAIYIPFPEDDSNSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWN 198
Query: 1587 IFDFVVVILSIVGMFLADIIEKYFVSPTL--------FRVIRLARIGRILRLIKGAKGIR 1638
+ DFV+VI+ + + L + ++ + +R R+ R LRL+ G ++
Sbjct: 199 LLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQ 258
Query: 1639 TLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGI---------------- 1682
+L +++ ++ L +I LL+ V+ I++I G+ F H+
Sbjct: 259 VVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHKTCFFADSDIVAEEDPAPCA 318
Query: 1683 -----------------------DDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 319 FSGNGRQCTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITMEGWTDVLYWV----- 373
Query: 1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADP 1779
+ ++ E P +FVS II+ V+N+ + ++ FS E++
Sbjct: 374 NDAIGWEWPW--------------VYFVSLIILGSFFVLNLVLGVLSGEFSKEREKAK-- 417
Query: 1780 LSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ DF+ E ++ + D ++++ A+ D
Sbjct: 418 -ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 449
Score = 63.5 bits (153), Expect = 2e-09
Identities = 92/426 (21%), Positives = 166/426 (38%), Gaps = 97/426 (22%)
Query: 136 MIIMCTILTNCVFMTFSNPPDWSKNVE----YTFTGIYTFESLVKIIARGFCIDGFTFLR 191
+I++ + T + N PDW ++ ++T E LVK+ + G +
Sbjct: 549 VIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQ----AYFV 604
Query: 192 DPWNWLDFSVIMMAYITEFVNLG-------NVSALRTFRVLRALKTISVIPGLKTIVGAL 244
+N D V+ ITE + + +S R R+LR K L +V +L
Sbjct: 605 SLFNRFDCFVVCGG-ITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASL 663
Query: 245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEE 304
+ S+K ++ +++L + +F+L+G+QLF G NF+E+ + T FD
Sbjct: 664 LNSMKSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDETQTKRST--FD--- 709
Query: 305 YINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALF 364
NF + +L G +A Y + A P+
Sbjct: 710 ------NFPQALLTVFQILTGEDWNAVM----YDGIMAYGGPS----------------- 742
Query: 365 RLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVA---MAYEEQNQAT 421
++G I+F+++ G++ L+N+ LA+ E N A
Sbjct: 743 -----------------SSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQ 785
Query: 422 LEEAEQKEAEFKAMLEQLK-KQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEI 480
EEAE+KE + A E L+ K+ + + +A S V+ D EE E+ P +
Sbjct: 786 KEEAEEKERKKIARKESLENKKNNKPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPV 845
Query: 481 SKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKF 540
++ +++E E E P + SE M+ K +P+ G F
Sbjct: 846 G--------------EEEEEEEEDEPEVPAGPRP--RRISELNMKEKIAPIPE---GSAF 886
Query: 541 SIMNQS 546
I++++
Sbjct: 887 FILSKT 892
Score = 62.4 bits (150), Expect = 4e-09
Identities = 44/181 (24%), Positives = 94/181 (51%), Gaps = 12/181 (6%)
Query: 730 FLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEH-VLAVG 788
F++ + +P + +++N + F +L I + I+L++ +A E + F + +L
Sbjct: 887 FILSKTNPIRVGCHKLINHHI---FTNL-ILVFIMLSSAALAAEDPIRSHSFRNTILGYF 942
Query: 789 NLVFTGIFTAEMFLKLIAMDPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSV 842
+ FT IFT E+ LK+ + + + +N+ D +V +SL+ + + + +
Sbjct: 943 DYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSSAISVVKI 1002
Query: 843 LRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
LR R+LR + L +++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 1003 LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY 1062
Query: 902 K 902
+
Sbjct: 1063 R 1063
Score = 55.5 bits (132), Expect = 5e-07
Identities = 65/277 (23%), Positives = 109/277 (39%), Gaps = 60/277 (21%)
Query: 134 FSMIIMCTILTNCVFMTFSNPP----DWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189
+ M ++ + T C+ M D + FTG++T E ++K+IA F G+
Sbjct: 1229 YMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA--FKPKGY-- 1284
Query: 190 LRDPWNWLDFSVIMMAYI---------TEFVNL-------GN--------VSALRTFRVL 225
D WN D +++ + I TE N+ GN ++ R FRV+
Sbjct: 1285 FSDAWNTFDSLIVIGSIIDVALSEADPTESENVPVPTATPGNSEESNRISITFFRLFRVM 1344
Query: 226 RALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP 285
R +K +S G++T++ I+S + L V +L ++A+IG+Q+F
Sbjct: 1345 RLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMF------------ 1392
Query: 286 INFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQ-----CPEGYQC- 339
G IN NF T P + L + +A Q C G C
Sbjct: 1393 ----------GKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCD 1442
Query: 340 MKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLY 376
++ NP YT F+ + F ++ NL+
Sbjct: 1443 PESDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLF 1479
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 330 bits (846), Expect = 8e-90
Identities = 185/611 (30%), Positives = 337/611 (55%), Gaps = 38/611 (6%)
Query: 1188 RKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEM 1247
R +C ++ H F+ ++ I L+ +A E I+ T R L ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1248 LLKWTAYGFVK----FFTNAWCWLDFLIVAVSLVSLI---ANALGYSELGAIKSLRTLRA 1300
++K A G + + ++W LD L+V VSLV ++ A+A G LG ++ LR LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1301 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNET 1360
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GK++YC
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGP- 1462
Query: 1361 SEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMY 1420
+ +++ K +C RW K NFDN+G ++L +++ GW++IMY
Sbjct: 1463 -----DTRNISTKAQCRA------AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMY 1511
Query: 1421 AAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIF 1480
+D+ D+QP N +M +YF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1512 DGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEAR 1571
Query: 1481 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMM 1540
EE K +++ K ++P + + + T D+ I +IC+N++TM
Sbjct: 1572 RREE--KRLRRLERRRRKAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMS 1629
Query: 1541 VETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVG 1599
+E Q K ++ L + N VF I F E LK+ A +F WN D +V+LS++G
Sbjct: 1630 MEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMG 1689
Query: 1600 MFLADI--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLL 1657
+ L +I ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP + N+GLL
Sbjct: 1690 ITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLL 1749
Query: 1658 LFLVMFIFSIFGMSNFAYVKHE-----AGIDDMFNFETFGNSMICLFQITTSAGWDGLLL 1712
L+ FI++ G+ F ++ G+ F FG + + LF+++T W+G++
Sbjct: 1750 FMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMK 1809
Query: 1713 PILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVA 1772
L +CS + +H S P++ +FV++++++ ++VN+ +A+++++ +
Sbjct: 1810 DTLR---ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEES 1860
Query: 1773 TEESADPLSED 1783
+E+ + D
Sbjct: 1861 NKEAREDAELD 1871
Score = 138 bits (347), Expect = 6e-32
Identities = 83/258 (32%), Positives = 139/258 (53%), Gaps = 9/258 (3%)
Query: 739 WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTA 798
W+ + IV + I + I++NTL M +E+H + + L + N+VFT +F
Sbjct: 779 WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
Query: 799 EMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSW 858
EM LKL+A P Y + +NIFDG IV +S+ E+ GLSVLR+FRLLRV KL +
Sbjct: 839 EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
Query: 859 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELP-RW 917
P L + ++ ++ + +L + +FIF+++GM LFG + K + +P R
Sbjct: 899 PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955
Query: 918 HMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALL 976
+ + + VF++L E W +++ M + + + F+ +M GN V+ NL +A+L
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
Query: 977 LSSFSAD---NLAATDDD 991
+ F A+ N + TD+D
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032
Score = 126 bits (317), Expect = 2e-28
Identities = 98/414 (23%), Positives = 182/414 (43%), Gaps = 78/414 (18%)
Query: 108 ATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK------NV 161
A + L R ++++ + F + M I+ NCV + P + + N+
Sbjct: 76 AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
Query: 162 EYTFTGI----YTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI---MMAYITEFVNLG 214
F + E ++K++A G +L D WN LDF ++ MM Y + N+
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV- 193
Query: 215 NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 274
++SA+RT RVLR L+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+
Sbjct: 194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
Query: 275 GNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQ-- 332
G LRN+C + + +++ N F + + T G P +C + D G
Sbjct: 254 GLLRNRCFL-----DSAFVRNNNLTF-------LRPYYQTEEGEENPFICSSRRDNGMQK 301
Query: 333 -------------CPEGYQ--------------------------CMKAGRNPNYGYTSF 353
C G++ C NP+ G +F
Sbjct: 302 CSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINF 361
Query: 354 DTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMA 413
D +A++A+F+++T + W ++ + A I+F+L+I VGSF+++NL L V+A
Sbjct: 362 DNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQ 421
Query: 414 YEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEG 467
+ +E K+ E + M EQ + A + G+ E+ ++ G
Sbjct: 422 F----------SETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVG 465
Score = 112 bits (279), Expect = 5e-24
Identities = 89/364 (24%), Positives = 154/364 (42%), Gaps = 74/364 (20%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP---PDWSKNV-----E 162
ALY+ SP N R K++ H +F +++ I NCV + P P ++ V
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
Query: 163 YTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---------L 213
Y FT I+ E +VK++A G +L+ WN LD +++++ + V L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
Query: 214 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
G + LR R LR L+ IS PGLK +V LI S++ + +++++ +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
Query: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
G FY G D
Sbjct: 1453 KG-----------------------------------KFYYCEG----------PDTRNI 1467
Query: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG--------- 384
QC A +FD A ++LF L ++D W N+ L A G
Sbjct: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527
Query: 385 -KTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQ 443
+++F+ + + SF+++N+ + VV + + Q +EAE+ + L +L++++
Sbjct: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQH--QEAEEARRREEKRLRRLERRR 1585
Query: 444 EEAQ 447
+AQ
Sbjct: 1586 RKAQ 1589
Score = 110 bits (275), Expect = 1e-23
Identities = 75/260 (28%), Positives = 129/260 (49%), Gaps = 27/260 (10%)
Query: 754 FVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYF 813
++DL IT I +N + M+MEH+ + L N VFT +F E LKL+A +F
Sbjct: 1612 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1671
Query: 814 QEGWNIFDGFIVSLSLMELSLADVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 863
++ WN D IV LSLM ++L ++E + ++R R+ RV KL K +
Sbjct: 1672 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1731
Query: 864 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWH--MHD 921
L+ + ++ +GNL L+ ++ FI+A +G++LFG+ C + CE H +
Sbjct: 1732 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1787
Query: 922 FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ----------AMCLIVFMMVMVIGNLVVLN 970
F +FL +FRV G+ W M D + + A+ + F+ +++ V++N
Sbjct: 1788 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1847
Query: 971 LFLALLLSSFSADNLAATDD 990
+ +A+L+ N A +D
Sbjct: 1848 VVVAVLMKHLEESNKEARED 1867
Score = 96.3 bits (238), Expect = 3e-19
Identities = 73/290 (25%), Positives = 136/290 (46%), Gaps = 37/290 (12%)
Query: 1507 PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVE-TDTQSKQMENILYWI-NLVFVIF 1564
P N+ + +T + FD V+++ I LN VT+ +E D E + + N +F
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
Query: 1565 FTCECVLKMFAL-----RHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVI 1619
F E ++K+ AL H Y WN+ D ++V++S+V + +A + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
Query: 1620 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF------ 1673
RL R R LR+I A G++ ++ L+ SL + NI L+ IF I G+ F
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
Query: 1674 --------------AYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
H + +NF+ G +++ LF +++ GW ++ L+
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA-- 1516
Query: 1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1769
+D++ + NP + + +F+S+++I V+NM++ +++ENF
Sbjct: 1517 -VGVDQQPVQN------HNPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 95.5 bits (236), Expect = 5e-19
Identities = 71/269 (26%), Positives = 129/269 (47%), Gaps = 37/269 (13%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTP-QFEHV-LAVGNLVFTGIFTAEMFLKLIA 806
++ D + + I LN + +A+E + P E V L+V N +FT IF AEM +K++A
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVA 1349
Query: 807 MD----PYYYFQEGWNIFDGFIVSLSLMELSLADVEG--------LSVLRSFRLLRVFKL 854
+ + Y Q WN+ DG +V +SL+++ +A L VLR R LR ++
Sbjct: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409
Query: 855 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------K 902
P L ++++ + +S+ +GN+ L+ IF ++G+QLF GK Y
Sbjct: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469
Query: 903 ECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QA 951
+ C+ + R + D L+ VL + W+ M+D ++ G
Sbjct: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529
Query: 952 MCLIVFMMVMVIGNLVVLNLFLALLLSSF 980
L+ F+ ++I + VLN+F+ +++ +F
Sbjct: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 92.0 bits (227), Expect = 5e-18
Identities = 80/301 (26%), Positives = 134/301 (44%), Gaps = 41/301 (13%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRH 1578
V + F IMM I +N ++M VE Q +++ N L N+VF F E +LK+ A
Sbjct: 790 VDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGP 849
Query: 1579 Y-YFTIGWNIFDFVVVILS---IVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGA 1634
Y +NIFD ++V++S IVG + V+R R+ R+L+L++
Sbjct: 850 LGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVLKLVRFL 898
Query: 1635 KGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA---YVKHEAG--IDDMFNFE 1689
+R L L+ ++ + LL L +FIFSI GM F +K + G + D NF+
Sbjct: 899 PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFD 958
Query: 1690 TFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSY 1749
+ +++ +FQI T W+ +L + G S +FV+
Sbjct: 959 SLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSWAALYFVAL 998
Query: 1750 IIISFLIVVNMYIAIILENFSVATEESADPLSEDDFET-FYEIWEKFDPDATQFIEYCKL 1808
+ ++ N+ +AI++E F + + ED F E + K T ++ C L
Sbjct: 999 MTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSL 1058
Query: 1809 A 1809
A
Sbjct: 1059 A 1059
Score = 89.7 bits (221), Expect = 2e-17
Identities = 70/291 (24%), Positives = 132/291 (45%), Gaps = 44/291 (15%)
Query: 1180 LGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVF 1239
+G+ W IV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VF
Sbjct: 775 MGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVF 832
Query: 1240 TYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLR 1299
T +F LEMLLK A G + + N + D +IV +S+ ++ A G + LRT R
Sbjct: 833 TSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFR 887
Query: 1300 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNE 1359
LR L+ + +R + LV + ++ + ++F IFSI+G++LF K+
Sbjct: 888 LLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF------ 941
Query: 1360 TSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIM 1419
+ KT+ + NFD++ + + Q+ T + W ++
Sbjct: 942 -----------SLKTDTGDTVPDRK----------NFDSLLWAIVTVFQILTQEDWNVVL 980
Query: 1420 YAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1470
Y + S + + +YFV + FG++ NL + ++++ F +
Sbjct: 981 YNGMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 89.4 bits (220), Expect = 3e-17
Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 14/185 (7%)
Query: 1188 RKTCFLIVEHNWFETFIIFMILLSSGALAF----EDIYIEQRKTIRTILEYADKVFTYIF 1243
R C +V + WFE + +I+L+ L ED+ + ILE D F
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
Query: 1244 ILEMLLKWTAYGFVK---FFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRA 1300
+EM++K A G + + W LDF IV ++ + S + ++RT+R
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS----LSAIRTVRV 203
Query: 1301 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCFNE 1359
LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG + CF +
Sbjct: 204 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLD 263
Query: 1360 TSEIR 1364
++ +R
Sbjct: 264 SAFVR 268
Score = 87.8 bits (216), Expect = 9e-17
Identities = 74/331 (22%), Positives = 138/331 (41%), Gaps = 90/331 (27%)
Query: 133 VFSMIIMCTILTNCVFMTFSNPPDWS---KNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189
+F I+C + ++ P K Y FT ++ FE+ +K++A GF F
Sbjct: 1615 LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGF----RRF 1670
Query: 190 LRDPWNWLDFSVIMMAY----ITEF-------VNLGNVSALRTFRVLRALKTISVIPGLK 238
+D WN LD ++++++ + E +N + +R R+ R LK + + G++
Sbjct: 1671 FKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1730
Query: 239 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTK 298
++ ++Q++ ++ ++ +L + ++A +G++LF
Sbjct: 1731 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------------------------- 1765
Query: 299 GFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSW 358
G LE C E C R + +F F
Sbjct: 1766 ------------------GRLE------------CSEDNPCEGLSR-----HATFSNFGM 1790
Query: 359 AFLALFRLMTQDYWENLYQLTLRAAGK------TYM-----IFFVLVIFVGSFYLVNLIL 407
AFL LFR+ T D W + + TLR + +Y+ ++FV + V F LVN+++
Sbjct: 1791 AFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVV 1850
Query: 408 AVVAMAYEEQNQATLEEAEQKEAEFKAMLEQ 438
AV+ EE N+ E+AE +AE + + Q
Sbjct: 1851 AVLMKHLEESNKEAREDAE-LDAEIELEMAQ 1880
Score = 74.3 bits (181), Expect = 1e-12
Identities = 43/133 (32%), Positives = 71/133 (53%), Gaps = 13/133 (9%)
Query: 1391 NVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIF 1450
N INFDN+G ++A+ QV T +GW+DIMY +D+ + Y +IYF++ II
Sbjct: 356 NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFYNFIYFILLIIV 405
Query: 1451 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1510
GSFF +NL + VI F++ K++ + M E++ ++ + L S L K
Sbjct: 406 GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
Query: 1511 IQGIVFDFVTQQA 1523
G +F V +++
Sbjct: 463 YVGHIFRKVKRRS 475
Score = 65.5 bits (158), Expect = 5e-10
Identities = 43/157 (27%), Positives = 81/157 (51%), Gaps = 8/157 (5%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAM----EHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL 804
+V +P+ + + I+LN + + M E + ++L + F EM +K+
Sbjct: 96 LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
Query: 805 IAMDPY---YYFQEGWNIFDGFIVSLSLMELSLADVE-GLSVLRSFRLLRVFKLAKSWPT 860
+A+ + Y + WN D FIV +ME SL LS +R+ R+LR + P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
Query: 861 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
+ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 64.7 bits (156), Expect = 9e-10
Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 127 KILIHSVFSMIIMCTILTNCVFMTFS---NPPDWSKNVEYT---FTGIYTFESLVKIIAR 180
+I+ FS IM IL N + M P + + +E + FT ++ E L+K++A
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNL--GNVSALRTFRVLRALKTISVIPGLK 238
G ++R+P+N D +I++ + E V G +S LRTFR+LR LK + +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
Query: 239 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
+ L++++ ++ L + + +F+++G+ LF
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 62.4 bits (150), Expect = 4e-09
Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 16/172 (9%)
Query: 1524 FDIVIMMLICLNMVTMMV----ETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY 1579
F+ V M++I LN VT+ + E + NIL + FF E V+KM AL +
Sbjct: 102 FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161
Query: 1580 ----YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1635
Y WN DF +V+ ++ L + + VS IR R+ R LR I
Sbjct: 162 GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214
Query: 1636 GIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA-YVKHEAGIDDMF 1686
+R L+ L+ +LP L N+ LL F V FIF I G+ +A +++ +D F
Sbjct: 215 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
Score = 45.8 bits (107), Expect = 4e-04
Identities = 19/94 (20%), Positives = 51/94 (54%), Gaps = 2/94 (2%)
Query: 352 SFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVA 411
+FD+ WA + +F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Query: 412 MAYEEQNQATLEEAEQKE--AEFKAMLEQLKKQQ 443
++ + A + ++ + F+ +L++ Q
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQ 1049
Score = 32.3 bits (72), Expect = 4.7
Identities = 17/96 (17%), Positives = 38/96 (39%), Gaps = 20/96 (20%)
Query: 1687 NFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFF 1746
NF+ G + I +FQ+ T GW ++ +++ + +F
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMD--------------------AHSFYNFIYF 399
Query: 1747 VSYIIISFLIVVNMYIAIILENFSVATEESADPLSE 1782
+ II+ ++N+ + +I FS + + + E
Sbjct: 400 ILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
Score = 32.3 bits (72), Expect = 4.7
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 924 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981
++++ +F+V+ E W++ M+ M+ A I F++++++G+ ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
>gi|193788548 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 20 [Homo sapiens]
Length = 2127
Score = 327 bits (838), Expect = 7e-89
Identities = 234/784 (29%), Positives = 405/784 (51%), Gaps = 45/784 (5%)
Query: 1099 AVGESDFENLNTEDVSSESD-PEGSKDKLDDTSSSEGSTIDIKPEVE---EVPVEQPEEY 1154
AVGES E + + ++++ + P +K +DD +E P E E E+PE
Sbjct: 795 AVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMP 854
Query: 1155 LDP------DACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMI 1208
+ P + E V + I + R C IV F I+F I
Sbjct: 855 VGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR----FRLQCHRIVNDTIFTNLILFFI 910
Query: 1209 LLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAW 1264
LLSS +LA ED ++ IL AD VFT IF LE++LK TAYG F N +
Sbjct: 911 LLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYF 969
Query: 1265 CWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1324
LD L+V+VSL+S + S + +K LR LR LRPLRA++R +G++ VV + AI
Sbjct: 970 NILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1026
Query: 1325 PSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNN 1384
+I N+++V + +F+ +GV LF GK + C + + + E + N T + ++
Sbjct: 1027 RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG-NYITYKDGEVDHPI 1085
Query: 1385 TEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ R W+N K +FDNV A +AL V+TF+GW +++Y ++DS D+ P Y + + I+
Sbjct: 1086 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1502
F+I+II +FF +N+F+G +I F +Q G Q+ E K ++ +P ++
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1201
Query: 1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFV 1562
IP+ N+ Q V+ V F+ ++ +LI LN + + ++ QS + + +N++F
Sbjct: 1202 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1259
Query: 1563 IFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
FT E +LK+ A + +YF WN FD ++V+ SIV + + ++ S RL
Sbjct: 1260 GLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRL 1319
Query: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV--KHE 1679
R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+++ GM F +
Sbjct: 1320 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1379
Query: 1680 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGD--CG 1737
I+ NF+TF +++ LF+ T W ++L + P + P + +G+ CG
Sbjct: 1380 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCG 1437
Query: 1738 NPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDP 1797
+ S +F+F+S+ ++ +++N+++A+I++NF T + + L + F IW ++DP
Sbjct: 1438 S-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDP 1495
Query: 1798 DATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFT 1852
+A I++ + ++ PL K P+ + L++M++P+ S + LFA
Sbjct: 1496 EAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALV 1555
Query: 1853 KRVL 1856
+ L
Sbjct: 1556 RTAL 1559
Score = 161 bits (407), Expect = 7e-39
Identities = 124/441 (28%), Positives = 204/441 (46%), Gaps = 79/441 (17%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL L+ N IRR I I+ F +II+ TI NCV + P P+ N V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN--------- 212
EY F I+T E+ +K+IA G +LR+ WN LDF ++++ + +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 213 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 265
LG +V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 266 ALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCG 325
A+IGL+LFMG + C N+ VP +P C
Sbjct: 283 AIIGLELFMGKMHKTCY-------------------------NQEGIADVPAEDDPSPCA 317
Query: 326 NSSDAG-QCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG 384
+ G QC G C P +G T+FD F++A L +F+ +T + W ++ A G
Sbjct: 318 LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVG 377
Query: 385 KTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKAM 435
+ + I+FV +I +GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 378 RDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGY 437
Query: 436 LEQLKK-------------QQEEAQAAAMAT----SAGTVSEDAIEEEGEEGGGSPRSSS 478
L+ + + +E+ + +M T S T + + EGE G R +
Sbjct: 438 LDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGA--RLAH 495
Query: 479 EISKLSSKSAKERRNRRKKRK 499
ISK R NR +RK
Sbjct: 496 RISKSKFSRYWRRWNRFCRRK 516
Score = 147 bits (372), Expect = 8e-35
Identities = 107/328 (32%), Positives = 161/328 (49%), Gaps = 39/328 (11%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE FE I+ I + ALA IYI + + LE + +F I
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLI---------ANALGYSEL 1289
F +E LK AYG + + N W LDF+IV V L S I ANALG
Sbjct: 170 FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229
Query: 1290 GA-IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1348
G +K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+ L
Sbjct: 230 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289
Query: 1349 FAGKYH-YCFNETSEIRFEIEDVNNKTECE-----KLMEGNNTEIRWKNVK---INFDNV 1399
F GK H C+N+ ED + E + G + W K NFDN
Sbjct: 290 FMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNF 349
Query: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459
L + Q T +GW D++Y D+ D + +IYFV II GSFF LNL
Sbjct: 350 AFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLV 400
Query: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
+GV+ F+++++K + F +K+
Sbjct: 401 LGVLSGEFSKEREKAKARGDFQKLREKQ 428
Score = 124 bits (311), Expect = 9e-28
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 20/248 (8%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + LNTL +A EH+ V N +FTAEM LK+ ++ YF +N
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V ++E L + + G+SVLR RLLR+FK+ + W +L+ L+ + NSV
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F S L VF++L
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQIL 703
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS-ADNL 985
GE W M+D + G +C I F+++ + GN ++LN+FLA+ + + + A++L
Sbjct: 704 TGEDWNSVMYDGIMAYGGPSFPGMLVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 762
Query: 986 AATDDDGE 993
+ + E
Sbjct: 763 TSAQKEEE 770
Score = 122 bits (307), Expect = 3e-27
Identities = 81/297 (27%), Positives = 150/297 (50%), Gaps = 36/297 (12%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K + + K+ +VN + + + + I+LNT+ +
Sbjct: 1181 ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN----STYFEYLMFVLILLNTICL 1236
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F+ + + N++FTG+FT EM LKLIA P +YF + WN FD IV S++
Sbjct: 1237 AMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIV 1296
Query: 831 ELSLADVE--------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 882
++++ +V ++ R FR++R+ KL + L+ S AL + L++
Sbjct: 1297 DIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1356
Query: 883 AIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE-WIETM 941
++ FI+AV+GMQ+FGK +IN++ + F + L++FR GE W + M
Sbjct: 1357 VMLFFIYAVIGMQVFGKIALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIM 1411
Query: 942 WDCM------------------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSF 980
CM G + + F+ ++ +++NLF+A+++ +F
Sbjct: 1412 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
Score = 102 bits (255), Expect = 3e-21
Identities = 96/424 (22%), Positives = 177/424 (41%), Gaps = 59/424 (13%)
Query: 1099 AVGESDFENLNT-----EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEE 1153
A DF+ L ED+ D + +D + EG + KP +P + E
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEE-KPRNMSMPTSETES 473
Query: 1154 YLDPDACFTEGCVQRFKCCQVNIEEGLGKS----WW-----ILRKTCFLIVEHNWFETFI 1204
+ G + C + + KS +W R+ C V+ N F +
Sbjct: 474 VNTENVA---GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLV 530
Query: 1205 IFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAW 1264
IF++ L++ +A E + Q + + + A+K +F EMLLK + G +F + +
Sbjct: 531 IFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1265 CWLD-FLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1323
D F++ L +++ S LG I LR +R LR + + + +V +L+ +
Sbjct: 589 NRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1324 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGN 1383
+ SI ++LL+ +F +IFS++G+ LF GK+++ +T
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR---------------------- 685
Query: 1384 NTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ FDN L + Q+ T + W +MY + + P + + IY
Sbjct: 686 ---------RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP----GMLVCIY 732
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
F+I I G++ LN+F+ + +DN + Q EE+K+ + +K Q+
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EEEEEKERKKLARTASPEKKQEL 790
Query: 1504 IPRP 1507
+ +P
Sbjct: 791 VEKP 794
Score = 98.2 bits (243), Expect = 7e-20
Identities = 105/439 (23%), Positives = 186/439 (42%), Gaps = 77/439 (17%)
Query: 15 KPFTPESLAN-IERRIAESKLKKPPKA----DGSHREDDEDSKPKPNSDL--EAGKSLPF 67
KP ES IE + + + PP D ++ED P PN + E + P
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEP- 851
Query: 68 IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIK 127
++P G PL + +L +K + A +I S N R +
Sbjct: 852 ---EMPVGPRPRPLSEL---HLKEKAVPM----------PEASAFFIFSSNNRFRLQCHR 895
Query: 128 ILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK-------NVEYTFTGIYTFESLVKIIAR 180
I+ ++F+ +I+ IL + + + +P + N +Y FT I+T E ++K+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 955
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---LGNVSALRTFRVLRALKTISVIPGL 237
G + +F R+ +N LD V+ ++ I+ + + V LR RVLR L+ I+ GL
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 238 KTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT 297
K +V + +++ + +++I+T +FA IG+QLF G L + + + E
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL------YTCSDSSKQTEAEC 1069
Query: 298 KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFS 357
KG YI K P +++P NS FD
Sbjct: 1070 KG----NYITYKDGEVDHP-IIQPRSWENSK----------------------FDFDNVL 1102
Query: 358 WAFLALFRLMTQDYWENLYQLTLRA----AGKTY------MIFFVLVIFVGSFYLVNLIL 407
A +ALF + T + W L ++ + G Y IFF++ I + +F+++N+ +
Sbjct: 1103 AAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFV 1162
Query: 408 AVVAMAYEEQNQATLEEAE 426
V + ++EQ + + E
Sbjct: 1163 GFVIVTFQEQGEQEYKNCE 1181
Score = 86.7 bits (213), Expect = 2e-16
Identities = 90/398 (22%), Positives = 168/398 (42%), Gaps = 94/398 (23%)
Query: 1482 TEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICLN 1535
T+ +++ Y KK GS +P PR L N I+ V + F+I+I++ I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137
Query: 1536 MVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFALR-----HYYFTIGWNI 1587
V + + + S + L + +F+I FT E LK+ A + Y GWN+
Sbjct: 138 CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197
Query: 1588 FDFVVVILSIVGMFLADIIEKYFVSPTL-----------FRVIRLARIGRILRLIKGAKG 1636
DF++V +VG+F A I+E+ + + +R R+ R LRL+ G
Sbjct: 198 LDFIIV---VVGLFSA-ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253
Query: 1637 IRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKH-----EAGIDD------- 1684
++ +L +++ ++ L +I LL+ V+ I++I G+ F H + GI D
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313
Query: 1685 -----------------------------MFNFETFGNSMICLFQITTSAGWDGLLLPIL 1715
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV- 372
Query: 1716 NRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEE 1775
+ ++ ++ P +FV+ III V+N+ + ++ FS E+
Sbjct: 373 ----NDAVGRDWPW--------------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 1776 SADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ + DF+ E ++ + D ++++ A+ D
Sbjct: 415 AK---ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 448
Score = 85.9 bits (211), Expect = 4e-16
Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 25/288 (8%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F +++ L+ LN +T+ E Q + + N + FT E +LKM++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I+ L +E +SP V+R R+ RI ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDM----FNFETFGN 1693
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + D+M F+ F
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG---GKFNFDEMQTRRSTFDNFPQ 694
Query: 1694 SMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIIS 1753
S++ +FQI T W+ ++ + + G F G V I+F + +I +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGI---------MAYGGPSFPG----MLVCIYFIILFICGN 741
Query: 1754 FLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
+ I++N+++AI ++N + A ++ E++ + ++ P+ Q
Sbjct: 742 Y-ILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQ 788
Score = 81.6 bits (200), Expect = 7e-15
Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 64/298 (21%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL-----VFTGIFTAEM 800
++++ PF ++ I + I N + +A+ + P+ + NL +F IFT E
Sbjct: 118 ISIVEWKPF-EIIILLTIFANCVALAI--YIPFPEDDSNATNSNLERVEYLFLIIFTVEA 174
Query: 801 FLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVE---------------GLS 841
FLK+IA P Y + GWN+ D IV + L L +
Sbjct: 175 FLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVK 234
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 235 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKM 294
Query: 901 YKECV--------------------------CKINQDCELPRW--------HMHDFFHSF 926
+K C C+ C+ P W + +F +
Sbjct: 295 HKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-PGWDGPKHGITNFDNFAFAM 353
Query: 927 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
L VF+ + E W + ++ + G+ I F+ +++IG+ VLNL L +L FS +
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411
Score = 69.7 bits (169), Expect = 3e-11
Identities = 47/161 (29%), Positives = 83/161 (51%), Gaps = 8/161 (4%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFE-HVLAVGNLVFTGIFTAEMFLKLIAM 807
IV D I I+L+++ +A E F H+L + VFT IFT E+ LK+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 955
Query: 808 DPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSVLRSFRLLRVFKLAKSWPTL 861
+ + + +NI D +VS+SL+ + + + +LR R+LR + L
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 862 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
+++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Score = 55.8 bits (133), Expect = 4e-07
Identities = 38/122 (31%), Positives = 65/122 (53%), Gaps = 21/122 (17%)
Query: 165 FTGIYTFESLVKIIA----RGFCIDGFTFLRDPWNWLDFSVIMMAY----ITEFVNLG-- 214
FTG++T E ++K+IA FC D WN D +++ + ITE N
Sbjct: 1258 FTGLFTVEMILKLIAFKPKHYFC--------DAWNTFDALIVVGSIVDIAITEVNNAEEN 1309
Query: 215 ---NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQ 271
+++ R FRV+R +K +S G++T++ I+S + L V +L V ++A+IG+Q
Sbjct: 1310 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1369
Query: 272 LF 273
+F
Sbjct: 1370 VF 1371
Score = 51.2 bits (121), Expect = 1e-05
Identities = 55/240 (22%), Positives = 99/240 (41%), Gaps = 52/240 (21%)
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNVEYT----FTGIYTFESLVK 176
R A+K +VF +++ + N + + N P+W V+ T ++T E L+K
Sbjct: 518 RAAVK---SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLK 574
Query: 177 IIARGFCIDGFTFLRDPWNWLDFSVIMMAYI------TEFVNLGNVSALRTFRVLRALKT 230
+ + G + +N D V+ + T+ ++ +S LR R+LR K
Sbjct: 575 MYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 231 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNE 290
L +V +L+ SV+ ++ +++L + +F+L+G+QLF G NF+E
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDE 681
Query: 291 SYLENGT---------------KGFDWEEYINNKTNFY---TVPGMLEPL------LCGN 326
T G DW + + Y + PGML + +CGN
Sbjct: 682 MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGN 741
Score = 50.4 bits (119), Expect = 2e-05
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 21/197 (10%)
Query: 351 TSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRAAGKTY-----MIFFVLVIFVGSFYLVN 404
++FD F + L +F+++T + W + +Y + G ++ I+F+++ G++ L+N
Sbjct: 687 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLN 746
Query: 405 LILAVVA---MAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED 461
+ LA+ E A EE E+KE + A +K+QE + A+ G E+
Sbjct: 747 VFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAV----GESKEE 802
Query: 462 AIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEE-KGDPEKVF---- 516
IE + G S +K++ + N K + GEE + +PE
Sbjct: 803 KIELKSITADG---ESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRP 859
Query: 517 KSESEDGMRRKAFRLPD 533
+ SE ++ KA +P+
Sbjct: 860 RPLSELHLKEKAVPMPE 876
>gi|193788534 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 12 [Homo sapiens]
Length = 2146
Score = 327 bits (838), Expect = 7e-89
Identities = 234/784 (29%), Positives = 405/784 (51%), Gaps = 45/784 (5%)
Query: 1099 AVGESDFENLNTEDVSSESD-PEGSKDKLDDTSSSEGSTIDIKPEVE---EVPVEQPEEY 1154
AVGES E + + ++++ + P +K +DD +E P E E E+PE
Sbjct: 795 AVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMP 854
Query: 1155 LDP------DACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMI 1208
+ P + E V + I + R C IV F I+F I
Sbjct: 855 VGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR----FRLQCHRIVNDTIFTNLILFFI 910
Query: 1209 LLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAW 1264
LLSS +LA ED ++ IL AD VFT IF LE++LK TAYG F N +
Sbjct: 911 LLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYF 969
Query: 1265 CWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1324
LD L+V+VSL+S + S + +K LR LR LRPLRA++R +G++ VV + AI
Sbjct: 970 NILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1026
Query: 1325 PSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNN 1384
+I N+++V + +F+ +GV LF GK + C + + + E + N T + ++
Sbjct: 1027 RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG-NYITYKDGEVDHPI 1085
Query: 1385 TEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ R W+N K +FDNV A +AL V+TF+GW +++Y ++DS D+ P Y + + I+
Sbjct: 1086 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1502
F+I+II +FF +N+F+G +I F +Q G Q+ E K ++ +P ++
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1201
Query: 1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFV 1562
IP+ N+ Q V+ V F+ ++ +LI LN + + ++ QS + + +N++F
Sbjct: 1202 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1259
Query: 1563 IFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
FT E +LK+ A + +YF WN FD ++V+ SIV + + ++ S RL
Sbjct: 1260 GLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRL 1319
Query: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV--KHE 1679
R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+++ GM F +
Sbjct: 1320 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1379
Query: 1680 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGD--CG 1737
I+ NF+TF +++ LF+ T W ++L + P + P + +G+ CG
Sbjct: 1380 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCG 1437
Query: 1738 NPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDP 1797
+ S +F+F+S+ ++ +++N+++A+I++NF T + + L + F IW ++DP
Sbjct: 1438 S-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDP 1495
Query: 1798 DATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFT 1852
+A I++ + ++ PL K P+ + L++M++P+ S + LFA
Sbjct: 1496 EAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALV 1555
Query: 1853 KRVL 1856
+ L
Sbjct: 1556 RTAL 1559
Score = 161 bits (407), Expect = 7e-39
Identities = 124/441 (28%), Positives = 204/441 (46%), Gaps = 79/441 (17%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL L+ N IRR I I+ F +II+ TI NCV + P P+ N V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN--------- 212
EY F I+T E+ +K+IA G +LR+ WN LDF ++++ + +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 213 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 265
LG +V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 266 ALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCG 325
A+IGL+LFMG + C N+ VP +P C
Sbjct: 283 AIIGLELFMGKMHKTCY-------------------------NQEGIADVPAEDDPSPCA 317
Query: 326 NSSDAG-QCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG 384
+ G QC G C P +G T+FD F++A L +F+ +T + W ++ A G
Sbjct: 318 LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVG 377
Query: 385 KTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKAM 435
+ + I+FV +I +GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 378 RDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGY 437
Query: 436 LEQLKK-------------QQEEAQAAAMAT----SAGTVSEDAIEEEGEEGGGSPRSSS 478
L+ + + +E+ + +M T S T + + EGE G R +
Sbjct: 438 LDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGA--RLAH 495
Query: 479 EISKLSSKSAKERRNRRKKRK 499
ISK R NR +RK
Sbjct: 496 RISKSKFSRYWRRWNRFCRRK 516
Score = 147 bits (372), Expect = 8e-35
Identities = 107/328 (32%), Positives = 161/328 (49%), Gaps = 39/328 (11%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE FE I+ I + ALA IYI + + LE + +F I
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLI---------ANALGYSEL 1289
F +E LK AYG + + N W LDF+IV V L S I ANALG
Sbjct: 170 FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229
Query: 1290 GA-IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1348
G +K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+ L
Sbjct: 230 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289
Query: 1349 FAGKYH-YCFNETSEIRFEIEDVNNKTECE-----KLMEGNNTEIRWKNVK---INFDNV 1399
F GK H C+N+ ED + E + G + W K NFDN
Sbjct: 290 FMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNF 349
Query: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459
L + Q T +GW D++Y D+ D + +IYFV II GSFF LNL
Sbjct: 350 AFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLV 400
Query: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
+GV+ F+++++K + F +K+
Sbjct: 401 LGVLSGEFSKEREKAKARGDFQKLREKQ 428
Score = 124 bits (311), Expect = 9e-28
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 20/248 (8%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + LNTL +A EH+ V N +FTAEM LK+ ++ YF +N
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V ++E L + + G+SVLR RLLR+FK+ + W +L+ L+ + NSV
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F S L VF++L
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQIL 703
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS-ADNL 985
GE W M+D + G +C I F+++ + GN ++LN+FLA+ + + + A++L
Sbjct: 704 TGEDWNSVMYDGIMAYGGPSFPGMLVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 762
Query: 986 AATDDDGE 993
+ + E
Sbjct: 763 TSAQKEEE 770
Score = 122 bits (307), Expect = 3e-27
Identities = 81/297 (27%), Positives = 150/297 (50%), Gaps = 36/297 (12%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K + + K+ +VN + + + + I+LNT+ +
Sbjct: 1181 ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN----STYFEYLMFVLILLNTICL 1236
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F+ + + N++FTG+FT EM LKLIA P +YF + WN FD IV S++
Sbjct: 1237 AMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIV 1296
Query: 831 ELSLADVE--------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 882
++++ +V ++ R FR++R+ KL + L+ S AL + L++
Sbjct: 1297 DIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1356
Query: 883 AIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE-WIETM 941
++ FI+AV+GMQ+FGK +IN++ + F + L++FR GE W + M
Sbjct: 1357 VMLFFIYAVIGMQVFGKIALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIM 1411
Query: 942 WDCM------------------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSF 980
CM G + + F+ ++ +++NLF+A+++ +F
Sbjct: 1412 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
Score = 102 bits (255), Expect = 3e-21
Identities = 96/424 (22%), Positives = 177/424 (41%), Gaps = 59/424 (13%)
Query: 1099 AVGESDFENLNT-----EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEE 1153
A DF+ L ED+ D + +D + EG + KP +P + E
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEE-KPRNMSMPTSETES 473
Query: 1154 YLDPDACFTEGCVQRFKCCQVNIEEGLGKS----WW-----ILRKTCFLIVEHNWFETFI 1204
+ G + C + + KS +W R+ C V+ N F +
Sbjct: 474 VNTENVA---GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLV 530
Query: 1205 IFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAW 1264
IF++ L++ +A E + Q + + + A+K +F EMLLK + G +F + +
Sbjct: 531 IFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1265 CWLD-FLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1323
D F++ L +++ S LG I LR +R LR + + + +V +L+ +
Sbjct: 589 NRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1324 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGN 1383
+ SI ++LL+ +F +IFS++G+ LF GK+++ +T
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR---------------------- 685
Query: 1384 NTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ FDN L + Q+ T + W +MY + + P + + IY
Sbjct: 686 ---------RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP----GMLVCIY 732
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
F+I I G++ LN+F+ + +DN + Q EE+K+ + +K Q+
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EEEEEKERKKLARTASPEKKQEL 790
Query: 1504 IPRP 1507
+ +P
Sbjct: 791 VEKP 794
Score = 98.2 bits (243), Expect = 7e-20
Identities = 105/439 (23%), Positives = 186/439 (42%), Gaps = 77/439 (17%)
Query: 15 KPFTPESLAN-IERRIAESKLKKPPKA----DGSHREDDEDSKPKPNSDL--EAGKSLPF 67
KP ES IE + + + PP D ++ED P PN + E + P
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEP- 851
Query: 68 IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIK 127
++P G PL + +L +K + A +I S N R +
Sbjct: 852 ---EMPVGPRPRPLSEL---HLKEKAVPM----------PEASAFFIFSSNNRFRLQCHR 895
Query: 128 ILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK-------NVEYTFTGIYTFESLVKIIAR 180
I+ ++F+ +I+ IL + + + +P + N +Y FT I+T E ++K+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 955
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---LGNVSALRTFRVLRALKTISVIPGL 237
G + +F R+ +N LD V+ ++ I+ + + V LR RVLR L+ I+ GL
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 238 KTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT 297
K +V + +++ + +++I+T +FA IG+QLF G L + + + E
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL------YTCSDSSKQTEAEC 1069
Query: 298 KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFS 357
KG YI K P +++P NS FD
Sbjct: 1070 KG----NYITYKDGEVDHP-IIQPRSWENSK----------------------FDFDNVL 1102
Query: 358 WAFLALFRLMTQDYWENLYQLTLRA----AGKTY------MIFFVLVIFVGSFYLVNLIL 407
A +ALF + T + W L ++ + G Y IFF++ I + +F+++N+ +
Sbjct: 1103 AAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFV 1162
Query: 408 AVVAMAYEEQNQATLEEAE 426
V + ++EQ + + E
Sbjct: 1163 GFVIVTFQEQGEQEYKNCE 1181
Score = 86.7 bits (213), Expect = 2e-16
Identities = 90/398 (22%), Positives = 168/398 (42%), Gaps = 94/398 (23%)
Query: 1482 TEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICLN 1535
T+ +++ Y KK GS +P PR L N I+ V + F+I+I++ I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137
Query: 1536 MVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFALR-----HYYFTIGWNI 1587
V + + + S + L + +F+I FT E LK+ A + Y GWN+
Sbjct: 138 CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197
Query: 1588 FDFVVVILSIVGMFLADIIEKYFVSPTL-----------FRVIRLARIGRILRLIKGAKG 1636
DF++V +VG+F A I+E+ + + +R R+ R LRL+ G
Sbjct: 198 LDFIIV---VVGLFSA-ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253
Query: 1637 IRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKH-----EAGIDD------- 1684
++ +L +++ ++ L +I LL+ V+ I++I G+ F H + GI D
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313
Query: 1685 -----------------------------MFNFETFGNSMICLFQITTSAGWDGLLLPIL 1715
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV- 372
Query: 1716 NRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEE 1775
+ ++ ++ P +FV+ III V+N+ + ++ FS E+
Sbjct: 373 ----NDAVGRDWPW--------------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 1776 SADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ + DF+ E ++ + D ++++ A+ D
Sbjct: 415 AK---ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 448
Score = 85.9 bits (211), Expect = 4e-16
Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 25/288 (8%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F +++ L+ LN +T+ E Q + + N + FT E +LKM++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I+ L +E +SP V+R R+ RI ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDM----FNFETFGN 1693
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + D+M F+ F
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG---GKFNFDEMQTRRSTFDNFPQ 694
Query: 1694 SMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIIS 1753
S++ +FQI T W+ ++ + + G F G V I+F + +I +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGI---------MAYGGPSFPG----MLVCIYFIILFICGN 741
Query: 1754 FLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
+ I++N+++AI ++N + A ++ E++ + ++ P+ Q
Sbjct: 742 Y-ILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQ 788
Score = 81.6 bits (200), Expect = 7e-15
Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 64/298 (21%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL-----VFTGIFTAEM 800
++++ PF ++ I + I N + +A+ + P+ + NL +F IFT E
Sbjct: 118 ISIVEWKPF-EIIILLTIFANCVALAI--YIPFPEDDSNATNSNLERVEYLFLIIFTVEA 174
Query: 801 FLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVE---------------GLS 841
FLK+IA P Y + GWN+ D IV + L L +
Sbjct: 175 FLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVK 234
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 235 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKM 294
Query: 901 YKECV--------------------------CKINQDCELPRW--------HMHDFFHSF 926
+K C C+ C+ P W + +F +
Sbjct: 295 HKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-PGWDGPKHGITNFDNFAFAM 353
Query: 927 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
L VF+ + E W + ++ + G+ I F+ +++IG+ VLNL L +L FS +
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411
Score = 69.7 bits (169), Expect = 3e-11
Identities = 47/161 (29%), Positives = 83/161 (51%), Gaps = 8/161 (4%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFE-HVLAVGNLVFTGIFTAEMFLKLIAM 807
IV D I I+L+++ +A E F H+L + VFT IFT E+ LK+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 955
Query: 808 DPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSVLRSFRLLRVFKLAKSWPTL 861
+ + + +NI D +VS+SL+ + + + +LR R+LR + L
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 862 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
+++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Score = 55.8 bits (133), Expect = 4e-07
Identities = 38/122 (31%), Positives = 65/122 (53%), Gaps = 21/122 (17%)
Query: 165 FTGIYTFESLVKIIA----RGFCIDGFTFLRDPWNWLDFSVIMMAY----ITEFVNLG-- 214
FTG++T E ++K+IA FC D WN D +++ + ITE N
Sbjct: 1258 FTGLFTVEMILKLIAFKPKHYFC--------DAWNTFDALIVVGSIVDIAITEVNNAEEN 1309
Query: 215 ---NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQ 271
+++ R FRV+R +K +S G++T++ I+S + L V +L V ++A+IG+Q
Sbjct: 1310 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1369
Query: 272 LF 273
+F
Sbjct: 1370 VF 1371
Score = 51.2 bits (121), Expect = 1e-05
Identities = 55/240 (22%), Positives = 99/240 (41%), Gaps = 52/240 (21%)
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNVEYT----FTGIYTFESLVK 176
R A+K +VF +++ + N + + N P+W V+ T ++T E L+K
Sbjct: 518 RAAVK---SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLK 574
Query: 177 IIARGFCIDGFTFLRDPWNWLDFSVIMMAYI------TEFVNLGNVSALRTFRVLRALKT 230
+ + G + +N D V+ + T+ ++ +S LR R+LR K
Sbjct: 575 MYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 231 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNE 290
L +V +L+ SV+ ++ +++L + +F+L+G+QLF G NF+E
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDE 681
Query: 291 SYLENGT---------------KGFDWEEYINNKTNFY---TVPGMLEPL------LCGN 326
T G DW + + Y + PGML + +CGN
Sbjct: 682 MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGN 741
Score = 50.4 bits (119), Expect = 2e-05
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 21/197 (10%)
Query: 351 TSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRAAGKTY-----MIFFVLVIFVGSFYLVN 404
++FD F + L +F+++T + W + +Y + G ++ I+F+++ G++ L+N
Sbjct: 687 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLN 746
Query: 405 LILAVVA---MAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED 461
+ LA+ E A EE E+KE + A +K+QE + A+ G E+
Sbjct: 747 VFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAV----GESKEE 802
Query: 462 AIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEE-KGDPEKVF---- 516
IE + G S +K++ + N K + GEE + +PE
Sbjct: 803 KIELKSITADG---ESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRP 859
Query: 517 KSESEDGMRRKAFRLPD 533
+ SE ++ KA +P+
Sbjct: 860 RPLSELHLKEKAVPMPE 876
>gi|193788538 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 15 [Homo sapiens]
Length = 2138
Score = 327 bits (837), Expect = 9e-89
Identities = 238/795 (29%), Positives = 411/795 (51%), Gaps = 56/795 (7%)
Query: 1099 AVGESDFENLNTEDVSSESD-PEGSKDKLDDTSSSEGSTIDIKPEVE---EVPVEQPEEY 1154
AVGES E + + ++++ + P +K +DD +E P E E E+PE
Sbjct: 795 AVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMP 854
Query: 1155 LDP------DACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMI 1208
+ P + E V + I + R C IV F I+F I
Sbjct: 855 VGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR----FRLQCHRIVNDTIFTNLILFFI 910
Query: 1209 LLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAW 1264
LLSS +LA ED ++ IL AD VFT IF LE++LK TAYG F N +
Sbjct: 911 LLSSISLAAEDP-VQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYF 969
Query: 1265 CWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1324
LD L+V+VSL+S + S + +K LR LR LRPLRA++R +G++ VV + AI
Sbjct: 970 NILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1026
Query: 1325 PSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNN 1384
+I N+++V + +F+ +GV LF GK + C + + + E + N T + ++
Sbjct: 1027 RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG-NYITYKDGEVDHPI 1085
Query: 1385 TEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ R W+N K +FDNV A +AL V+TF+GW +++Y ++DS D+ P Y + + I+
Sbjct: 1086 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1502
F+I+II +FF +N+F+G +I F +Q G Q+ E K ++ +P ++
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1201
Query: 1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFV 1562
IP+ N+ Q V+ V F+ ++ +LI LN + + ++ QS + + +N++F
Sbjct: 1202 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1259
Query: 1563 IFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADI--IEKYFVSPTL---- 1615
FT E +LK+ A + YF+ WN+FDF++VI SI+ + L++ E SP++
Sbjct: 1260 GLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEE 1319
Query: 1616 -----FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGM 1670
RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+++ GM
Sbjct: 1320 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1379
Query: 1671 SNFAYV--KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHP 1728
F + I+ NF+TF +++ LF+ T W ++L + P + P
Sbjct: 1380 QVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEP 1437
Query: 1729 GSGFKGD--CGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFE 1786
+ +G+ CG+ S +F+F+S+ ++ +++N+++A+I++NF T + + L +
Sbjct: 1438 SNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLD 1495
Query: 1787 TFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDR 1841
F IW ++DP+A I++ + ++ PL K P+ + L++M++P+ S
Sbjct: 1496 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGT 1555
Query: 1842 IHCLDILFAFTKRVL 1856
+ LFA + L
Sbjct: 1556 VMFNATLFALVRTAL 1570
Score = 161 bits (407), Expect = 7e-39
Identities = 124/441 (28%), Positives = 204/441 (46%), Gaps = 79/441 (17%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL L+ N IRR I I+ F +II+ TI NCV + P P+ N V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN--------- 212
EY F I+T E+ +K+IA G +LR+ WN LDF ++++ + +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 213 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 265
LG +V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 266 ALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCG 325
A+IGL+LFMG + C N+ VP +P C
Sbjct: 283 AIIGLELFMGKMHKTCY-------------------------NQEGIADVPAEDDPSPCA 317
Query: 326 NSSDAG-QCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG 384
+ G QC G C P +G T+FD F++A L +F+ +T + W ++ A G
Sbjct: 318 LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVG 377
Query: 385 KTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKAM 435
+ + I+FV +I +GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 378 RDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGY 437
Query: 436 LEQLKK-------------QQEEAQAAAMAT----SAGTVSEDAIEEEGEEGGGSPRSSS 478
L+ + + +E+ + +M T S T + + EGE G R +
Sbjct: 438 LDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGA--RLAH 495
Query: 479 EISKLSSKSAKERRNRRKKRK 499
ISK R NR +RK
Sbjct: 496 RISKSKFSRYWRRWNRFCRRK 516
Score = 147 bits (372), Expect = 8e-35
Identities = 107/328 (32%), Positives = 161/328 (49%), Gaps = 39/328 (11%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE FE I+ I + ALA IYI + + LE + +F I
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLI---------ANALGYSEL 1289
F +E LK AYG + + N W LDF+IV V L S I ANALG
Sbjct: 170 FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229
Query: 1290 GA-IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1348
G +K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+ L
Sbjct: 230 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289
Query: 1349 FAGKYH-YCFNETSEIRFEIEDVNNKTECE-----KLMEGNNTEIRWKNVK---INFDNV 1399
F GK H C+N+ ED + E + G + W K NFDN
Sbjct: 290 FMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNF 349
Query: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459
L + Q T +GW D++Y D+ D + +IYFV II GSFF LNL
Sbjct: 350 AFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLV 400
Query: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
+GV+ F+++++K + F +K+
Sbjct: 401 LGVLSGEFSKEREKAKARGDFQKLREKQ 428
Score = 124 bits (311), Expect = 9e-28
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 20/248 (8%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + LNTL +A EH+ V N +FTAEM LK+ ++ YF +N
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V ++E L + + G+SVLR RLLR+FK+ + W +L+ L+ + NSV
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F S L VF++L
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQIL 703
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS-ADNL 985
GE W M+D + G +C I F+++ + GN ++LN+FLA+ + + + A++L
Sbjct: 704 TGEDWNSVMYDGIMAYGGPSFPGMLVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 762
Query: 986 AATDDDGE 993
+ + E
Sbjct: 763 TSAQKEEE 770
Score = 115 bits (288), Expect = 4e-25
Identities = 81/308 (26%), Positives = 149/308 (48%), Gaps = 47/308 (15%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K + + K+ +VN + + + + I+LNT+ +
Sbjct: 1181 ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN----STYFEYLMFVLILLNTICL 1236
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F+ + + N++FTG+FT EM LKLIA P YF + WN+FD IV S++
Sbjct: 1237 AMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSII 1296
Query: 831 ELSLADVE-------------------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 871
++ L++ ++ R FR++R+ KL + L+ S
Sbjct: 1297 DVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKS 1356
Query: 872 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFR 931
AL + L++ ++ FI+AV+GMQ+FGK +IN++ + F + L++FR
Sbjct: 1357 FQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN-----NFQTFPQAVLLLFR 1411
Query: 932 VLCGE-WIETMWDCM------------------EVAGQAMCLIVFMMVMVIGNLVVLNLF 972
GE W + M CM G + + F+ ++ +++NLF
Sbjct: 1412 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1471
Query: 973 LALLLSSF 980
+A+++ +F
Sbjct: 1472 VAVIMDNF 1479
Score = 102 bits (255), Expect = 3e-21
Identities = 96/424 (22%), Positives = 177/424 (41%), Gaps = 59/424 (13%)
Query: 1099 AVGESDFENLNT-----EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEE 1153
A DF+ L ED+ D + +D + EG + KP +P + E
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEE-KPRNMSMPTSETES 473
Query: 1154 YLDPDACFTEGCVQRFKCCQVNIEEGLGKS----WW-----ILRKTCFLIVEHNWFETFI 1204
+ G + C + + KS +W R+ C V+ N F +
Sbjct: 474 VNTENVA---GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLV 530
Query: 1205 IFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAW 1264
IF++ L++ +A E + Q + + + A+K +F EMLLK + G +F + +
Sbjct: 531 IFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1265 CWLD-FLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1323
D F++ L +++ S LG I LR +R LR + + + +V +L+ +
Sbjct: 589 NRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1324 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGN 1383
+ SI ++LL+ +F +IFS++G+ LF GK+++ +T
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR---------------------- 685
Query: 1384 NTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ FDN L + Q+ T + W +MY + + P + + IY
Sbjct: 686 ---------RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP----GMLVCIY 732
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
F+I I G++ LN+F+ + +DN + Q EE+K+ + +K Q+
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EEEEEKERKKLARTASPEKKQEL 790
Query: 1504 IPRP 1507
+ +P
Sbjct: 791 VEKP 794
Score = 98.2 bits (243), Expect = 7e-20
Identities = 105/439 (23%), Positives = 186/439 (42%), Gaps = 77/439 (17%)
Query: 15 KPFTPESLAN-IERRIAESKLKKPPKA----DGSHREDDEDSKPKPNSDL--EAGKSLPF 67
KP ES IE + + + PP D ++ED P PN + E + P
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEP- 851
Query: 68 IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIK 127
++P G PL + +L +K + A +I S N R +
Sbjct: 852 ---EMPVGPRPRPLSEL---HLKEKAVPM----------PEASAFFIFSSNNRFRLQCHR 895
Query: 128 ILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK-------NVEYTFTGIYTFESLVKIIAR 180
I+ ++F+ +I+ IL + + + +P + N +Y FT I+T E ++K+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 955
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---LGNVSALRTFRVLRALKTISVIPGL 237
G + +F R+ +N LD V+ ++ I+ + + V LR RVLR L+ I+ GL
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 238 KTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT 297
K +V + +++ + +++I+T +FA IG+QLF G L + + + E
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL------YTCSDSSKQTEAEC 1069
Query: 298 KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFS 357
KG YI K P +++P NS FD
Sbjct: 1070 KG----NYITYKDGEVDHP-IIQPRSWENSK----------------------FDFDNVL 1102
Query: 358 WAFLALFRLMTQDYWENLYQLTLRA----AGKTY------MIFFVLVIFVGSFYLVNLIL 407
A +ALF + T + W L ++ + G Y IFF++ I + +F+++N+ +
Sbjct: 1103 AAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFV 1162
Query: 408 AVVAMAYEEQNQATLEEAE 426
V + ++EQ + + E
Sbjct: 1163 GFVIVTFQEQGEQEYKNCE 1181
Score = 86.7 bits (213), Expect = 2e-16
Identities = 90/398 (22%), Positives = 168/398 (42%), Gaps = 94/398 (23%)
Query: 1482 TEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICLN 1535
T+ +++ Y KK GS +P PR L N I+ V + F+I+I++ I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137
Query: 1536 MVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFALR-----HYYFTIGWNI 1587
V + + + S + L + +F+I FT E LK+ A + Y GWN+
Sbjct: 138 CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197
Query: 1588 FDFVVVILSIVGMFLADIIEKYFVSPTL-----------FRVIRLARIGRILRLIKGAKG 1636
DF++V +VG+F A I+E+ + + +R R+ R LRL+ G
Sbjct: 198 LDFIIV---VVGLFSA-ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253
Query: 1637 IRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKH-----EAGIDD------- 1684
++ +L +++ ++ L +I LL+ V+ I++I G+ F H + GI D
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313
Query: 1685 -----------------------------MFNFETFGNSMICLFQITTSAGWDGLLLPIL 1715
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV- 372
Query: 1716 NRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEE 1775
+ ++ ++ P +FV+ III V+N+ + ++ FS E+
Sbjct: 373 ----NDAVGRDWPW--------------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 1776 SADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ + DF+ E ++ + D ++++ A+ D
Sbjct: 415 AK---ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 448
Score = 85.9 bits (211), Expect = 4e-16
Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 25/288 (8%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F +++ L+ LN +T+ E Q + + N + FT E +LKM++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I+ L +E +SP V+R R+ RI ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDM----FNFETFGN 1693
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + D+M F+ F
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG---GKFNFDEMQTRRSTFDNFPQ 694
Query: 1694 SMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIIS 1753
S++ +FQI T W+ ++ + + G F G V I+F + +I +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGI---------MAYGGPSFPG----MLVCIYFIILFICGN 741
Query: 1754 FLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
+ I++N+++AI ++N + A ++ E++ + ++ P+ Q
Sbjct: 742 Y-ILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQ 788
Score = 81.6 bits (200), Expect = 7e-15
Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 64/298 (21%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL-----VFTGIFTAEM 800
++++ PF ++ I + I N + +A+ + P+ + NL +F IFT E
Sbjct: 118 ISIVEWKPF-EIIILLTIFANCVALAI--YIPFPEDDSNATNSNLERVEYLFLIIFTVEA 174
Query: 801 FLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVE---------------GLS 841
FLK+IA P Y + GWN+ D IV + L L +
Sbjct: 175 FLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVK 234
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 235 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKM 294
Query: 901 YKECV--------------------------CKINQDCELPRW--------HMHDFFHSF 926
+K C C+ C+ P W + +F +
Sbjct: 295 HKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-PGWDGPKHGITNFDNFAFAM 353
Query: 927 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
L VF+ + E W + ++ + G+ I F+ +++IG+ VLNL L +L FS +
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411
Score = 69.7 bits (169), Expect = 3e-11
Identities = 47/161 (29%), Positives = 83/161 (51%), Gaps = 8/161 (4%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFE-HVLAVGNLVFTGIFTAEMFLKLIAM 807
IV D I I+L+++ +A E F H+L + VFT IFT E+ LK+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAY 955
Query: 808 DPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSVLRSFRLLRVFKLAKSWPTL 861
+ + + +NI D +VS+SL+ + + + +LR R+LR + L
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 862 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
+++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Score = 58.9 bits (141), Expect = 5e-08
Identities = 38/129 (29%), Positives = 67/129 (51%), Gaps = 24/129 (18%)
Query: 165 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGN--------- 215
FTG++T E ++K+IA F G+ DPWN DF +++ + I ++ N
Sbjct: 1258 FTGLFTVEMILKLIA--FKPKGY--FSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSP 1313
Query: 216 -----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 264
++ R FRV+R +K +S G++T++ I+S + L V +L V +
Sbjct: 1314 SMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1373
Query: 265 FALIGLQLF 273
+A+IG+Q+F
Sbjct: 1374 YAVIGMQVF 1382
Score = 51.2 bits (121), Expect = 1e-05
Identities = 55/240 (22%), Positives = 99/240 (41%), Gaps = 52/240 (21%)
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNVEYT----FTGIYTFESLVK 176
R A+K +VF +++ + N + + N P+W V+ T ++T E L+K
Sbjct: 518 RAAVK---SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLK 574
Query: 177 IIARGFCIDGFTFLRDPWNWLDFSVIMMAYI------TEFVNLGNVSALRTFRVLRALKT 230
+ + G + +N D V+ + T+ ++ +S LR R+LR K
Sbjct: 575 MYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 231 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNE 290
L +V +L+ SV+ ++ +++L + +F+L+G+QLF G NF+E
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDE 681
Query: 291 SYLENGT---------------KGFDWEEYINNKTNFY---TVPGMLEPL------LCGN 326
T G DW + + Y + PGML + +CGN
Sbjct: 682 MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGN 741
Score = 50.4 bits (119), Expect = 2e-05
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 21/197 (10%)
Query: 351 TSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRAAGKTY-----MIFFVLVIFVGSFYLVN 404
++FD F + L +F+++T + W + +Y + G ++ I+F+++ G++ L+N
Sbjct: 687 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLN 746
Query: 405 LILAVVA---MAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED 461
+ LA+ E A EE E+KE + A +K+QE + A+ G E+
Sbjct: 747 VFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAV----GESKEE 802
Query: 462 AIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEE-KGDPEKVF---- 516
IE + G S +K++ + N K + GEE + +PE
Sbjct: 803 KIELKSITADG---ESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRP 859
Query: 517 KSESEDGMRRKAFRLPD 533
+ SE ++ KA +P+
Sbjct: 860 RPLSELHLKEKAVPMPE 876
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 326 bits (835), Expect = 2e-88
Identities = 185/616 (30%), Positives = 338/616 (54%), Gaps = 42/616 (6%)
Query: 1188 RKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEM 1247
R +C ++ H F+ ++ I L+ +A E I+ T R L ++ +FT IF+ EM
Sbjct: 1284 RVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEM 1343
Query: 1248 LLKWTAYGFVK----FFTNAWCWLDFLIVAVSLVSLI---ANALGYSELGAIKSLRTLRA 1300
++K A G + + ++W LD L+V VSLV ++ A+A G LG ++ LR LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 1301 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNET 1360
LRPLR +SR G+++VV L+ ++ I N++L+C F++IF I+GV LF GK++YC
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGP- 1462
Query: 1361 SEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMY 1420
+ +++ K +C RW K NFDN+G ++L +++ GW++IMY
Sbjct: 1463 -----DTRNISTKAQCRA------AHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMY 1511
Query: 1421 AAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIF 1480
+D+ D+QP N +M +YF+ F++ SFF LN+F+GV+++NF++ ++ ++
Sbjct: 1512 DGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEA- 1570
Query: 1481 MTEEQKKYYNAMKKLGSKKP-----QKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLN 1535
E+K+ ++ S P ++P + + + T D+ I +IC+N
Sbjct: 1571 RRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVN 1630
Query: 1536 MVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR-HYYFTIGWNIFDFVVVI 1594
++TM +E Q K ++ L + N VF I F E LK+ A +F WN D +V+
Sbjct: 1631 VITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVL 1690
Query: 1595 LSIVGMFLADI--IEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1652
LS++G+ L +I ++PT+ R++R+ RI R+L+L+K A G+R LL ++ +LP +
Sbjct: 1691 LSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVG 1750
Query: 1653 NIGLLLFLVMFIFSIFGMSNFAYVKHE-----AGIDDMFNFETFGNSMICLFQITTSAGW 1707
N+GLL L+ FI++ G+ F ++ G+ F FG + + LF+++T W
Sbjct: 1751 NLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNW 1810
Query: 1708 DGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILE 1767
+G++ L +CS + +H S P++ +FV++++++ ++VN+ +A++++
Sbjct: 1811 NGIMKDTLR---ECSREDKHCLSYL------PALSPVYFVTFVLVAQFVLVNVVVAVLMK 1861
Query: 1768 NFSVATEESADPLSED 1783
+ + +E+ + D
Sbjct: 1862 HLEESNKEAREDAELD 1877
Score = 138 bits (347), Expect = 6e-32
Identities = 83/258 (32%), Positives = 139/258 (53%), Gaps = 9/258 (3%)
Query: 739 WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTA 798
W+ + IV + I + I++NTL M +E+H + + L + N+VFT +F
Sbjct: 779 WVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFAL 838
Query: 799 EMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSW 858
EM LKL+A P Y + +NIFDG IV +S+ E+ GLSVLR+FRLLRV KL +
Sbjct: 839 EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFL 898
Query: 859 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELP-RW 917
P L + ++ ++ + +L + +FIF+++GM LFG + K + +P R
Sbjct: 899 PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFS---LKTDTGDTVPDRK 955
Query: 918 HMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALL 976
+ + + VF++L E W +++ M + + + F+ +M GN V+ NL +A+L
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGM-ASTSSWAALYFVALMTFGNYVLFNLLVAIL 1014
Query: 977 LSSFSAD---NLAATDDD 991
+ F A+ N + TD+D
Sbjct: 1015 VEGFQAEGDANRSDTDED 1032
Score = 126 bits (317), Expect = 2e-28
Identities = 98/414 (23%), Positives = 182/414 (43%), Gaps = 78/414 (18%)
Query: 108 ATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK------NV 161
A + L R ++++ + F + M I+ NCV + P + + N+
Sbjct: 76 AATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNI 135
Query: 162 EYTFTGI----YTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVI---MMAYITEFVNLG 214
F + E ++K++A G +L D WN LDF ++ MM Y + N+
Sbjct: 136 LEAFDAFIFAFFAVEMVIKMVALGL-FGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNV- 193
Query: 215 NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFM 274
++SA+RT RVLR L+ I+ +P ++ +V L+ ++ L +V++L F +F ++G+QL+
Sbjct: 194 SLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 253
Query: 275 GNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQ-- 332
G LRN+C + + +++ N F + + T G P +C + D G
Sbjct: 254 GLLRNRCFL-----DSAFVRNNNLTF-------LRPYYQTEEGEENPFICSSRRDNGMQK 301
Query: 333 -------------CPEGYQ--------------------------CMKAGRNPNYGYTSF 353
C G++ C NP+ G +F
Sbjct: 302 CSHIPGRRELRMPCTLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINF 361
Query: 354 DTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMA 413
D +A++A+F+++T + W ++ + A I+F+L+I VGSF+++NL L V+A
Sbjct: 362 DNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQ 421
Query: 414 YEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEG 467
+ +E K+ E + M EQ + A + G+ E+ ++ G
Sbjct: 422 F----------SETKQRESQLMREQRARHLSNDSTLASFSEPGSCYEELLKYVG 465
Score = 110 bits (275), Expect = 1e-23
Identities = 75/260 (28%), Positives = 129/260 (49%), Gaps = 27/260 (10%)
Query: 754 FVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYF 813
++DL IT I +N + M+MEH+ + L N VFT +F E LKL+A +F
Sbjct: 1618 YLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFF 1677
Query: 814 QEGWNIFDGFIVSLSLMELSLADVEG----------LSVLRSFRLLRVFKLAKSWPTLNM 863
++ WN D IV LSLM ++L ++E + ++R R+ RV KL K +
Sbjct: 1678 KDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRA 1737
Query: 864 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWH--MHD 921
L+ + ++ +GNL L+ ++ FI+A +G++LFG+ C + CE H +
Sbjct: 1738 LLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGR----LECSEDNPCEGLSRHATFSN 1793
Query: 922 FFHSFLIVFRVLCGE-WIETMWDCMEVAGQ----------AMCLIVFMMVMVIGNLVVLN 970
F +FL +FRV G+ W M D + + A+ + F+ +++ V++N
Sbjct: 1794 FGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVN 1853
Query: 971 LFLALLLSSFSADNLAATDD 990
+ +A+L+ N A +D
Sbjct: 1854 VVVAVLMKHLEESNKEARED 1873
Score = 108 bits (270), Expect = 5e-23
Identities = 88/359 (24%), Positives = 150/359 (41%), Gaps = 73/359 (20%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP---PDWSKNV-----E 162
ALY+ SP N R K++ H +F +++ I NCV + P P ++ V
Sbjct: 1273 ALYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSN 1332
Query: 163 YTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---------L 213
Y FT I+ E +VK++A G +L+ WN LD +++++ + V L
Sbjct: 1333 YIFTAIFVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKIL 1392
Query: 214 GNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
G + LR R LR L+ IS PGLK +V LI S++ + +++++ +F ++G+QLF
Sbjct: 1393 GVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLF 1452
Query: 274 MGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQC 333
G FY G D
Sbjct: 1453 KG-----------------------------------KFYYCEG----------PDTRNI 1467
Query: 334 PEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG--------- 384
QC A +FD A ++LF L ++D W N+ L A G
Sbjct: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527
Query: 385 -KTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQ-ATLEEAEQKEAEFKAMLEQLKK 441
+++F+ + + SF+++N+ + VV + + Q EEA ++E + LE+ ++
Sbjct: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR 1586
Score = 96.3 bits (238), Expect = 3e-19
Identities = 73/290 (25%), Positives = 136/290 (46%), Gaps = 37/290 (12%)
Query: 1507 PLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVE-TDTQSKQMENILYWI-NLVFVIF 1564
P N+ + +T + FD V+++ I LN VT+ +E D E + + N +F
Sbjct: 1279 PQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338
Query: 1565 FTCECVLKMFAL-----RHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVI 1619
F E ++K+ AL H Y WN+ D ++V++S+V + +A + RV+
Sbjct: 1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVL 1398
Query: 1620 RLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNF------ 1673
RL R R LR+I A G++ ++ L+ SL + NI L+ IF I G+ F
Sbjct: 1399 RLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYY 1458
Query: 1674 --------------AYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP 1719
H + +NF+ G +++ LF +++ GW ++ L+
Sbjct: 1459 CEGPDTRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDA-- 1516
Query: 1720 DCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENF 1769
+D++ + NP + + +F+S+++I V+NM++ +++ENF
Sbjct: 1517 -VGVDQQPVQN------HNPWM-LLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 95.5 bits (236), Expect = 5e-19
Identities = 71/269 (26%), Positives = 129/269 (47%), Gaps = 37/269 (13%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTP-QFEHV-LAVGNLVFTGIFTAEMFLKLIA 806
++ D + + I LN + +A+E + P E V L+V N +FT IF AEM +K++A
Sbjct: 1290 VITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVVA 1349
Query: 807 MD----PYYYFQEGWNIFDGFIVSLSLMELSLADVEG--------LSVLRSFRLLRVFKL 854
+ + Y Q WN+ DG +V +SL+++ +A L VLR R LR ++
Sbjct: 1350 LGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLRV 1409
Query: 855 AKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY-----------K 902
P L ++++ + +S+ +GN+ L+ IF ++G+QLF GK Y
Sbjct: 1410 ISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIST 1469
Query: 903 ECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE--WIETMWDCMEVAG---------QA 951
+ C+ + R + D L+ VL + W+ M+D ++ G
Sbjct: 1470 KAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNP 1529
Query: 952 MCLIVFMMVMVIGNLVVLNLFLALLLSSF 980
L+ F+ ++I + VLN+F+ +++ +F
Sbjct: 1530 WMLLYFISFLLIVSFFVLNMFVGVVVENF 1558
Score = 92.0 bits (227), Expect = 5e-18
Identities = 80/301 (26%), Positives = 134/301 (44%), Gaps = 41/301 (13%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRH 1578
V + F IMM I +N ++M VE Q +++ N L N+VF F E +LK+ A
Sbjct: 790 VDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGP 849
Query: 1579 Y-YFTIGWNIFDFVVVILS---IVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGA 1634
Y +NIFD ++V++S IVG + V+R R+ R+L+L++
Sbjct: 850 LGYIRNPYNIFDGIIVVISVWEIVGQADGGL-----------SVLRTFRLLRVLKLVRFL 898
Query: 1635 KGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA---YVKHEAG--IDDMFNFE 1689
+R L L+ ++ + LL L +FIFSI GM F +K + G + D NF+
Sbjct: 899 PALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFD 958
Query: 1690 TFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSY 1749
+ +++ +FQI T W+ +L + G S +FV+
Sbjct: 959 SLLWAIVTVFQILTQEDWNVVL--------------------YNGMASTSSWAALYFVAL 998
Query: 1750 IIISFLIVVNMYIAIILENFSVATEESADPLSEDDFET-FYEIWEKFDPDATQFIEYCKL 1808
+ ++ N+ +AI++E F + + ED F E + K T ++ C L
Sbjct: 999 MTFGNYVLFNLLVAILVEGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSL 1058
Query: 1809 A 1809
A
Sbjct: 1059 A 1059
Score = 89.7 bits (221), Expect = 2e-17
Identities = 70/291 (24%), Positives = 132/291 (45%), Gaps = 44/291 (15%)
Query: 1180 LGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVF 1239
+G+ W IV+ +F I+ IL+++ ++ E Y EQ + + LE ++ VF
Sbjct: 775 MGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVE--YHEQPEELTNALEISNIVF 832
Query: 1240 TYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLR 1299
T +F LEMLLK A G + + N + D +IV +S+ ++ A G + LRT R
Sbjct: 833 TSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQA-----DGGLSVLRTFR 887
Query: 1300 ALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNE 1359
LR L+ + +R + LV + ++ + ++F IFSI+G++LF K+
Sbjct: 888 LLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKF------ 941
Query: 1360 TSEIRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIM 1419
+ KT+ + NFD++ + + Q+ T + W ++
Sbjct: 942 -----------SLKTDTGDTVPDRK----------NFDSLLWAIVTVFQILTQEDWNVVL 980
Query: 1420 YAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1470
Y + S + + +YFV + FG++ NL + ++++ F +
Sbjct: 981 YNGMAS----------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE 1021
Score = 89.4 bits (220), Expect = 3e-17
Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 14/185 (7%)
Query: 1188 RKTCFLIVEHNWFETFIIFMILLSSGALAF----EDIYIEQRKTIRTILEYADKVFTYIF 1243
R C +V + WFE + +I+L+ L ED+ + ILE D F
Sbjct: 90 RSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERC--NILEAFDAFIFAFF 147
Query: 1244 ILEMLLKWTAYGFVK---FFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRA 1300
+EM++K A G + + W LDF IV ++ + S + ++RT+R
Sbjct: 148 AVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVS----LSAIRTVRV 203
Query: 1301 LRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKY-HYCFNE 1359
LRPLRA++R MR++V L+ +P + NVLL+C + IF I+GV L+AG + CF +
Sbjct: 204 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLD 263
Query: 1360 TSEIR 1364
++ +R
Sbjct: 264 SAFVR 268
Score = 87.8 bits (216), Expect = 9e-17
Identities = 74/331 (22%), Positives = 138/331 (41%), Gaps = 90/331 (27%)
Query: 133 VFSMIIMCTILTNCVFMTFSNPPDWS---KNVEYTFTGIYTFESLVKIIARGFCIDGFTF 189
+F I+C + ++ P K Y FT ++ FE+ +K++A GF F
Sbjct: 1621 LFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGF----RRF 1676
Query: 190 LRDPWNWLDFSVIMMAY----ITEF-------VNLGNVSALRTFRVLRALKTISVIPGLK 238
+D WN LD ++++++ + E +N + +R R+ R LK + + G++
Sbjct: 1677 FKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMR 1736
Query: 239 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTK 298
++ ++Q++ ++ ++ +L + ++A +G++LF
Sbjct: 1737 ALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF------------------------- 1771
Query: 299 GFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSW 358
G LE C E C R + +F F
Sbjct: 1772 ------------------GRLE------------CSEDNPCEGLSR-----HATFSNFGM 1796
Query: 359 AFLALFRLMTQDYWENLYQLTLRAAGK------TYM-----IFFVLVIFVGSFYLVNLIL 407
AFL LFR+ T D W + + TLR + +Y+ ++FV + V F LVN+++
Sbjct: 1797 AFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVV 1856
Query: 408 AVVAMAYEEQNQATLEEAEQKEAEFKAMLEQ 438
AV+ EE N+ E+AE +AE + + Q
Sbjct: 1857 AVLMKHLEESNKEAREDAE-LDAEIELEMAQ 1886
Score = 74.3 bits (181), Expect = 1e-12
Identities = 43/133 (32%), Positives = 71/133 (53%), Gaps = 13/133 (9%)
Query: 1391 NVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIF 1450
N INFDN+G ++A+ QV T +GW+DIMY +D+ + Y +IYF++ II
Sbjct: 356 NGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDAH----------SFYNFIYFILLIIV 405
Query: 1451 GSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNK 1510
GSFF +NL + VI F++ K++ + M E++ ++ + L S L K
Sbjct: 406 GSFFMINLCLVVIATQFSETKQR---ESQLMREQRARHLSNDSTLASFSEPGSCYEELLK 462
Query: 1511 IQGIVFDFVTQQA 1523
G +F V +++
Sbjct: 463 YVGHIFRKVKRRS 475
Score = 65.5 bits (158), Expect = 5e-10
Identities = 43/157 (27%), Positives = 81/157 (51%), Gaps = 8/157 (5%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAM----EHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKL 804
+V +P+ + + I+LN + + M E + ++L + F EM +K+
Sbjct: 96 LVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKM 155
Query: 805 IAMDPY---YYFQEGWNIFDGFIVSLSLMELSLADVE-GLSVLRSFRLLRVFKLAKSWPT 860
+A+ + Y + WN D FIV +ME SL LS +R+ R+LR + P+
Sbjct: 156 VALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRPLRAINRVPS 215
Query: 861 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 897
+ +L+ ++ +++ LGN+ L+ + FIF +VG+QL+
Sbjct: 216 MRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 252
Score = 64.7 bits (156), Expect = 9e-10
Identities = 44/155 (28%), Positives = 83/155 (53%), Gaps = 13/155 (8%)
Query: 127 KILIHSVFSMIIMCTILTNCVFMTFS---NPPDWSKNVEYT---FTGIYTFESLVKIIAR 180
+I+ FS IM IL N + M P + + +E + FT ++ E L+K++A
Sbjct: 788 RIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLAC 847
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNL--GNVSALRTFRVLRALKTISVIPGLK 238
G ++R+P+N D +I++ + E V G +S LRTFR+LR LK + +P L+
Sbjct: 848 G----PLGYIRNPYNIFD-GIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALR 902
Query: 239 TIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLF 273
+ L++++ ++ L + + +F+++G+ LF
Sbjct: 903 RQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLF 937
Score = 62.4 bits (150), Expect = 4e-09
Identities = 55/172 (31%), Positives = 82/172 (47%), Gaps = 16/172 (9%)
Query: 1524 FDIVIMMLICLNMVTMMV----ETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHY 1579
F+ V M++I LN VT+ + E + NIL + FF E V+KM AL +
Sbjct: 102 FEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIKMVALGLF 161
Query: 1580 ----YFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAK 1635
Y WN DF +V+ ++ L + + VS IR R+ R LR I
Sbjct: 162 GQKCYLGDTWNRLDFFIVVAGMMEYSL----DGHNVS---LSAIRTVRVLRPLRAINRVP 214
Query: 1636 GIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFA-YVKHEAGIDDMF 1686
+R L+ L+ +LP L N+ LL F V FIF I G+ +A +++ +D F
Sbjct: 215 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSAF 266
Score = 45.8 bits (107), Expect = 4e-04
Identities = 19/94 (20%), Positives = 51/94 (54%), Gaps = 2/94 (2%)
Query: 352 SFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVA 411
+FD+ WA + +F+++TQ+ W + + + ++FV ++ G++ L NL++A++
Sbjct: 956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILV 1015
Query: 412 MAYEEQNQATLEEAEQKE--AEFKAMLEQLKKQQ 443
++ + A + ++ + F+ +L++ Q
Sbjct: 1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQ 1049
Score = 32.3 bits (72), Expect = 4.7
Identities = 17/96 (17%), Positives = 38/96 (39%), Gaps = 20/96 (20%)
Query: 1687 NFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFF 1746
NF+ G + I +FQ+ T GW ++ +++ + +F
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMD--------------------AHSFYNFIYF 399
Query: 1747 VSYIIISFLIVVNMYIAIILENFSVATEESADPLSE 1782
+ II+ ++N+ + +I FS + + + E
Sbjct: 400 ILLIIVGSFFMINLCLVVIATQFSETKQRESQLMRE 435
Score = 32.3 bits (72), Expect = 4.7
Identities = 15/59 (25%), Positives = 38/59 (64%), Gaps = 2/59 (3%)
Query: 924 HSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS 981
++++ +F+V+ E W++ M+ M+ A I F++++++G+ ++NL L ++ + FS
Sbjct: 366 YAWIAIFQVITLEGWVDIMYYVMD-AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFS 423
>gi|193788532 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 11 [Homo sapiens]
Length = 2146
Score = 325 bits (834), Expect = 2e-88
Identities = 233/784 (29%), Positives = 404/784 (51%), Gaps = 45/784 (5%)
Query: 1099 AVGESDFENLNTEDVSSESD-PEGSKDKLDDTSSSEGSTIDIKPEVE---EVPVEQPEEY 1154
AVGES E + + ++++ + P +K +DD +E P E E E+PE
Sbjct: 795 AVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMP 854
Query: 1155 LDP------DACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMI 1208
+ P + E V + I + R C IV F I+F I
Sbjct: 855 VGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR----FRLQCHRIVNDTIFTNLILFFI 910
Query: 1209 LLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAW 1264
LLSS +LA ED ++ IL Y D VFT IF +E+ LK TAYG F N +
Sbjct: 911 LLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYF 969
Query: 1265 CWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1324
LD L+V+VSL+S + S + +K LR LR LRPLRA++R +G++ VV + AI
Sbjct: 970 NILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1026
Query: 1325 PSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNN 1384
+I N+++V + +F+ +GV LF GK + C + + + E + N T + ++
Sbjct: 1027 RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG-NYITYKDGEVDHPI 1085
Query: 1385 TEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ R W+N K +FDNV A +AL V+TF+GW +++Y ++DS D+ P Y + + I+
Sbjct: 1086 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1145
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1502
F+I+II +FF +N+F+G +I F +Q G Q+ E K ++ +P ++
Sbjct: 1146 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1201
Query: 1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFV 1562
IP+ N+ Q V+ V F+ ++ +LI LN + + ++ QS + + +N++F
Sbjct: 1202 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1259
Query: 1563 IFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRL 1621
FT E +LK+ A + +YF WN FD ++V+ SIV + + ++ S RL
Sbjct: 1260 GLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVNNAEENSRISITFFRL 1319
Query: 1622 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV--KHE 1679
R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+++ GM F +
Sbjct: 1320 FRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT 1379
Query: 1680 AGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGD--CG 1737
I+ NF+TF +++ LF+ T W ++L + P + P + +G+ CG
Sbjct: 1380 TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEPSNSTEGETPCG 1437
Query: 1738 NPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDP 1797
+ S +F+F+S+ ++ +++N+++A+I++NF T + + L + F IW ++DP
Sbjct: 1438 S-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKRIWAEYDP 1495
Query: 1798 DATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFT 1852
+A I++ + ++ PL K P+ + L++M++P+ S + LFA
Sbjct: 1496 EAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALV 1555
Query: 1853 KRVL 1856
+ L
Sbjct: 1556 RTAL 1559
Score = 161 bits (407), Expect = 7e-39
Identities = 124/441 (28%), Positives = 204/441 (46%), Gaps = 79/441 (17%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL L+ N IRR I I+ F +II+ TI NCV + P P+ N V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN--------- 212
EY F I+T E+ +K+IA G +LR+ WN LDF ++++ + +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 213 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 265
LG +V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 266 ALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCG 325
A+IGL+LFMG + C N+ VP +P C
Sbjct: 283 AIIGLELFMGKMHKTCY-------------------------NQEGIADVPAEDDPSPCA 317
Query: 326 NSSDAG-QCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG 384
+ G QC G C P +G T+FD F++A L +F+ +T + W ++ A G
Sbjct: 318 LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVG 377
Query: 385 KTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKAM 435
+ + I+FV +I +GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 378 RDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGY 437
Query: 436 LEQLKK-------------QQEEAQAAAMAT----SAGTVSEDAIEEEGEEGGGSPRSSS 478
L+ + + +E+ + +M T S T + + EGE G R +
Sbjct: 438 LDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGA--RLAH 495
Query: 479 EISKLSSKSAKERRNRRKKRK 499
ISK R NR +RK
Sbjct: 496 RISKSKFSRYWRRWNRFCRRK 516
Score = 147 bits (372), Expect = 8e-35
Identities = 107/328 (32%), Positives = 161/328 (49%), Gaps = 39/328 (11%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE FE I+ I + ALA IYI + + LE + +F I
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLI---------ANALGYSEL 1289
F +E LK AYG + + N W LDF+IV V L S I ANALG
Sbjct: 170 FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229
Query: 1290 GA-IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1348
G +K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+ L
Sbjct: 230 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289
Query: 1349 FAGKYH-YCFNETSEIRFEIEDVNNKTECE-----KLMEGNNTEIRWKNVK---INFDNV 1399
F GK H C+N+ ED + E + G + W K NFDN
Sbjct: 290 FMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNF 349
Query: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459
L + Q T +GW D++Y D+ D + +IYFV II GSFF LNL
Sbjct: 350 AFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLV 400
Query: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
+GV+ F+++++K + F +K+
Sbjct: 401 LGVLSGEFSKEREKAKARGDFQKLREKQ 428
Score = 124 bits (311), Expect = 9e-28
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 20/248 (8%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + LNTL +A EH+ V N +FTAEM LK+ ++ YF +N
Sbjct: 530 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 589
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V ++E L + + G+SVLR RLLR+FK+ + W +L+ L+ + NSV
Sbjct: 590 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 649
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F S L VF++L
Sbjct: 650 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQIL 703
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS-ADNL 985
GE W M+D + G +C I F+++ + GN ++LN+FLA+ + + + A++L
Sbjct: 704 TGEDWNSVMYDGIMAYGGPSFPGMLVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 762
Query: 986 AATDDDGE 993
+ + E
Sbjct: 763 TSAQKEEE 770
Score = 122 bits (307), Expect = 3e-27
Identities = 81/297 (27%), Positives = 150/297 (50%), Gaps = 36/297 (12%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K + + K+ +VN + + + + I+LNT+ +
Sbjct: 1181 ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN----STYFEYLMFVLILLNTICL 1236
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F+ + + N++FTG+FT EM LKLIA P +YF + WN FD IV S++
Sbjct: 1237 AMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIV 1296
Query: 831 ELSLADVE--------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVL 882
++++ +V ++ R FR++R+ KL + L+ S AL + L++
Sbjct: 1297 DIAITEVNNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLI 1356
Query: 883 AIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVLCGE-WIETM 941
++ FI+AV+GMQ+FGK +IN++ + F + L++FR GE W + M
Sbjct: 1357 VMLFFIYAVIGMQVFGKIALNDTTEINRNN-----NFQTFPQAVLLLFRCATGEAWQDIM 1411
Query: 942 WDCM------------------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSF 980
CM G + + F+ ++ +++NLF+A+++ +F
Sbjct: 1412 LACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1468
Score = 102 bits (255), Expect = 3e-21
Identities = 96/424 (22%), Positives = 177/424 (41%), Gaps = 59/424 (13%)
Query: 1099 AVGESDFENLNT-----EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEE 1153
A DF+ L ED+ D + +D + EG + KP +P + E
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEE-KPRNMSMPTSETES 473
Query: 1154 YLDPDACFTEGCVQRFKCCQVNIEEGLGKS----WW-----ILRKTCFLIVEHNWFETFI 1204
+ G + C + + KS +W R+ C V+ N F +
Sbjct: 474 VNTENVA---GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLV 530
Query: 1205 IFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAW 1264
IF++ L++ +A E + Q + + + A+K +F EMLLK + G +F + +
Sbjct: 531 IFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
Query: 1265 CWLD-FLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1323
D F++ L +++ S LG I LR +R LR + + + +V +L+ +
Sbjct: 589 NRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 647
Query: 1324 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGN 1383
+ SI ++LL+ +F +IFS++G+ LF GK+++ +T
Sbjct: 648 VRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR---------------------- 685
Query: 1384 NTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ FDN L + Q+ T + W +MY + + P + + IY
Sbjct: 686 ---------RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP----GMLVCIY 732
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
F+I I G++ LN+F+ + +DN + Q EE+K+ + +K Q+
Sbjct: 733 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EEEEEKERKKLARTASPEKKQEL 790
Query: 1504 IPRP 1507
+ +P
Sbjct: 791 VEKP 794
Score = 89.7 bits (221), Expect = 2e-17
Identities = 103/439 (23%), Positives = 183/439 (41%), Gaps = 77/439 (17%)
Query: 15 KPFTPESLAN-IERRIAESKLKKPPKA----DGSHREDDEDSKPKPNSDL--EAGKSLPF 67
KP ES IE + + + PP D ++ED P PN + E + P
Sbjct: 793 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEP- 851
Query: 68 IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIK 127
++P G PL + +L +K + A +I S N R +
Sbjct: 852 ---EMPVGPRPRPLSEL---HLKEKAVPM----------PEASAFFIFSSNNRFRLQCHR 895
Query: 128 ILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK-------NVEYTFTGIYTFESLVKIIAR 180
I+ ++F+ +I+ IL + + + +P + + FT I+T E +K+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 955
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---LGNVSALRTFRVLRALKTISVIPGL 237
G + +F R+ +N LD V+ ++ I+ + + V LR RVLR L+ I+ GL
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 238 KTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT 297
K +V + +++ + +++I+T +FA IG+QLF G L + + + E
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL------YTCSDSSKQTEAEC 1069
Query: 298 KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFS 357
KG YI K P +++P NS FD
Sbjct: 1070 KG----NYITYKDGEVDHP-IIQPRSWENSK----------------------FDFDNVL 1102
Query: 358 WAFLALFRLMTQDYWENLYQLTLRA----AGKTY------MIFFVLVIFVGSFYLVNLIL 407
A +ALF + T + W L ++ + G Y IFF++ I + +F+++N+ +
Sbjct: 1103 AAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFV 1162
Query: 408 AVVAMAYEEQNQATLEEAE 426
V + ++EQ + + E
Sbjct: 1163 GFVIVTFQEQGEQEYKNCE 1181
Score = 86.7 bits (213), Expect = 2e-16
Identities = 90/398 (22%), Positives = 168/398 (42%), Gaps = 94/398 (23%)
Query: 1482 TEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICLN 1535
T+ +++ Y KK GS +P PR L N I+ V + F+I+I++ I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137
Query: 1536 MVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFALR-----HYYFTIGWNI 1587
V + + + S + L + +F+I FT E LK+ A + Y GWN+
Sbjct: 138 CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197
Query: 1588 FDFVVVILSIVGMFLADIIEKYFVSPTL-----------FRVIRLARIGRILRLIKGAKG 1636
DF++V +VG+F A I+E+ + + +R R+ R LRL+ G
Sbjct: 198 LDFIIV---VVGLFSA-ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253
Query: 1637 IRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKH-----EAGIDD------- 1684
++ +L +++ ++ L +I LL+ V+ I++I G+ F H + GI D
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAEDDP 313
Query: 1685 -----------------------------MFNFETFGNSMICLFQITTSAGWDGLLLPIL 1715
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 314 SPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV- 372
Query: 1716 NRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEE 1775
+ ++ ++ P +FV+ III V+N+ + ++ FS E+
Sbjct: 373 ----NDAVGRDWPW--------------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREK 414
Query: 1776 SADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ + DF+ E ++ + D ++++ A+ D
Sbjct: 415 AK---ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 448
Score = 85.9 bits (211), Expect = 4e-16
Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 25/288 (8%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F +++ L+ LN +T+ E Q + + N + FT E +LKM++L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 580
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I+ L +E +SP V+R R+ RI ++ + +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 637
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDM----FNFETFGN 1693
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + D+M F+ F
Sbjct: 638 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG---GKFNFDEMQTRRSTFDNFPQ 694
Query: 1694 SMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIIS 1753
S++ +FQI T W+ ++ + + G F G V I+F + +I +
Sbjct: 695 SLLTVFQILTGEDWNSVMYDGI---------MAYGGPSFPG----MLVCIYFIILFICGN 741
Query: 1754 FLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
+ I++N+++AI ++N + A ++ E++ + ++ P+ Q
Sbjct: 742 Y-ILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQ 788
Score = 81.6 bits (200), Expect = 7e-15
Identities = 73/298 (24%), Positives = 132/298 (44%), Gaps = 64/298 (21%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL-----VFTGIFTAEM 800
++++ PF ++ I + I N + +A+ + P+ + NL +F IFT E
Sbjct: 118 ISIVEWKPF-EIIILLTIFANCVALAI--YIPFPEDDSNATNSNLERVEYLFLIIFTVEA 174
Query: 801 FLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVE---------------GLS 841
FLK+IA P Y + GWN+ D IV + L L +
Sbjct: 175 FLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVK 234
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 235 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKM 294
Query: 901 YKECV--------------------------CKINQDCELPRW--------HMHDFFHSF 926
+K C C+ C+ P W + +F +
Sbjct: 295 HKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCK-PGWDGPKHGITNFDNFAFAM 353
Query: 927 LIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
L VF+ + E W + ++ + G+ I F+ +++IG+ VLNL L +L FS +
Sbjct: 354 LTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 411
Score = 68.2 bits (165), Expect = 8e-11
Identities = 47/161 (29%), Positives = 84/161 (52%), Gaps = 8/161 (4%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFE-HVLAVGNLVFTGIFTAEMFLKLIAM 807
IV D I I+L+++ +A E F H+L ++VFT IFT E+ LK+ A
Sbjct: 896 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 955
Query: 808 DPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSVLRSFRLLRVFKLAKSWPTL 861
+ + + +NI D +VS+SL+ + + + +LR R+LR + L
Sbjct: 956 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1015
Query: 862 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
+++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 1016 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1056
Score = 55.8 bits (133), Expect = 4e-07
Identities = 38/122 (31%), Positives = 65/122 (53%), Gaps = 21/122 (17%)
Query: 165 FTGIYTFESLVKIIA----RGFCIDGFTFLRDPWNWLDFSVIMMAY----ITEFVNLG-- 214
FTG++T E ++K+IA FC D WN D +++ + ITE N
Sbjct: 1258 FTGLFTVEMILKLIAFKPKHYFC--------DAWNTFDALIVVGSIVDIAITEVNNAEEN 1309
Query: 215 ---NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQ 271
+++ R FRV+R +K +S G++T++ I+S + L V +L V ++A+IG+Q
Sbjct: 1310 SRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1369
Query: 272 LF 273
+F
Sbjct: 1370 VF 1371
Score = 51.2 bits (121), Expect = 1e-05
Identities = 55/240 (22%), Positives = 99/240 (41%), Gaps = 52/240 (21%)
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNVEYT----FTGIYTFESLVK 176
R A+K +VF +++ + N + + N P+W V+ T ++T E L+K
Sbjct: 518 RAAVK---SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLK 574
Query: 177 IIARGFCIDGFTFLRDPWNWLDFSVIMMAYI------TEFVNLGNVSALRTFRVLRALKT 230
+ + G + +N D V+ + T+ ++ +S LR R+LR K
Sbjct: 575 MYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 630
Query: 231 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNE 290
L +V +L+ SV+ ++ +++L + +F+L+G+QLF G NF+E
Sbjct: 631 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDE 681
Query: 291 SYLENGT---------------KGFDWEEYINNKTNFY---TVPGMLEPL------LCGN 326
T G DW + + Y + PGML + +CGN
Sbjct: 682 MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGN 741
Score = 50.4 bits (119), Expect = 2e-05
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 21/197 (10%)
Query: 351 TSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRAAGKTY-----MIFFVLVIFVGSFYLVN 404
++FD F + L +F+++T + W + +Y + G ++ I+F+++ G++ L+N
Sbjct: 687 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLN 746
Query: 405 LILAVVA---MAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED 461
+ LA+ E A EE E+KE + A +K+QE + A+ G E+
Sbjct: 747 VFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAV----GESKEE 802
Query: 462 AIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEE-KGDPEKVF---- 516
IE + G S +K++ + N K + GEE + +PE
Sbjct: 803 KIELKSITADG---ESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRP 859
Query: 517 KSESEDGMRRKAFRLPD 533
+ SE ++ KA +P+
Sbjct: 860 RPLSELHLKEKAVPMPE 876
>gi|193788544 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 19 [Homo sapiens]
Length = 2135
Score = 325 bits (833), Expect = 3e-88
Identities = 237/795 (29%), Positives = 410/795 (51%), Gaps = 56/795 (7%)
Query: 1099 AVGESDFENLNTEDVSSESD-PEGSKDKLDDTSSSEGSTIDIKPEVE---EVPVEQPEEY 1154
AVGES E + + ++++ + P +K +DD +E P E E E+PE
Sbjct: 792 AVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMP 851
Query: 1155 LDP------DACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMI 1208
+ P + E V + I + R C IV F I+F I
Sbjct: 852 VGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNR----FRLQCHRIVNDTIFTNLILFFI 907
Query: 1209 LLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAW 1264
LLSS +LA ED ++ IL Y D VFT IF +E+ LK TAYG F N +
Sbjct: 908 LLSSISLAAEDP-VQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYF 966
Query: 1265 CWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAI 1324
LD L+V+VSL+S + S + +K LR LR LRPLRA++R +G++ VV + AI
Sbjct: 967 NILDLLVVSVSLISF---GIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAI 1023
Query: 1325 PSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGNN 1384
+I N+++V + +F+ +GV LF GK + C + + + E + N T + ++
Sbjct: 1024 RTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKG-NYITYKDGEVDHPI 1082
Query: 1385 TEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ R W+N K +FDNV A +AL V+TF+GW +++Y ++DS D+ P Y + + I+
Sbjct: 1083 IQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIF 1142
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKP-QK 1502
F+I+II +FF +N+F+G +I F +Q G Q+ E K ++ +P ++
Sbjct: 1143 FIIYIIIIAFFMMNIFVGFVIVTFQEQ----GEQEYKNCELDKNQRQCVEYALKARPLRR 1198
Query: 1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFV 1562
IP+ N+ Q V+ V F+ ++ +LI LN + + ++ QS + + +N++F
Sbjct: 1199 YIPK--NQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFT 1256
Query: 1563 IFFTCECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLADI--IEKYFVSPTL---- 1615
FT E +LK+ A + YF+ WN+FDF++VI SI+ + L++ E SP++
Sbjct: 1257 GLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEE 1316
Query: 1616 -----FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGM 1670
RL R+ R+++L+ +GIRTLL+ + S AL + LL+ ++ FI+++ GM
Sbjct: 1317 NSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1376
Query: 1671 SNFAYV--KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHP 1728
F + I+ NF+TF +++ LF+ T W ++L + P + P
Sbjct: 1377 QVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM--PGKKCAPESEP 1434
Query: 1729 GSGFKGD--CGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFE 1786
+ +G+ CG+ S +F+F+S+ ++ +++N+++A+I++NF T + + L +
Sbjct: 1435 SNSTEGETPCGS-SFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLD 1492
Query: 1787 TFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDR 1841
F IW ++DP+A I++ + ++ PL K P+ + L++M++P+ S
Sbjct: 1493 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGT 1552
Query: 1842 IHCLDILFAFTKRVL 1856
+ LFA + L
Sbjct: 1553 VMFNATLFALVRTAL 1567
Score = 158 bits (399), Expect = 6e-38
Identities = 124/441 (28%), Positives = 204/441 (46%), Gaps = 82/441 (18%)
Query: 111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------V 161
AL L+ N IRR I I+ F +II+ TI NCV + P P+ N V
Sbjct: 103 ALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERV 162
Query: 162 EYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN--------- 212
EY F I+T E+ +K+IA G +LR+ WN LDF ++++ + +
Sbjct: 163 EYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGAN 222
Query: 213 -LG------NVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVF 265
LG +V ALR FRVLR L+ +S +P L+ ++ ++I+++ L + +L +F + ++
Sbjct: 223 ALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 282
Query: 266 ALIGLQLFMGNLRNKCVVWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCG 325
A+IGL+LFMG + C Y + G D +P C
Sbjct: 283 AIIGLELFMGKMHKTC----------YNQEGIAAED------------------DPSPCA 314
Query: 326 NSSDAG-QCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAG 384
+ G QC G C P +G T+FD F++A L +F+ +T + W ++ A G
Sbjct: 315 LETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVG 374
Query: 385 KTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT--------LEEAEQKEAEFKAM 435
+ + I+FV +I +GSF+++NL+L V++ + ++ + L E +Q E + K
Sbjct: 375 RDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGY 434
Query: 436 LEQLKK-------------QQEEAQAAAMAT----SAGTVSEDAIEEEGEEGGGSPRSSS 478
L+ + + +E+ + +M T S T + + EGE G R +
Sbjct: 435 LDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGA--RLAH 492
Query: 479 EISKLSSKSAKERRNRRKKRK 499
ISK R NR +RK
Sbjct: 493 RISKSKFSRYWRRWNRFCRRK 513
Score = 145 bits (365), Expect = 5e-34
Identities = 107/328 (32%), Positives = 161/328 (49%), Gaps = 42/328 (12%)
Query: 1187 LRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYI----EQRKTIRTILEYADKVFTYI 1242
+R+ C IVE FE I+ I + ALA IYI + + LE + +F I
Sbjct: 113 IRRACISIVEWKPFEIIILLTIFANCVALA---IYIPFPEDDSNATNSNLERVEYLFLII 169
Query: 1243 FILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLI---------ANALGYSEL 1289
F +E LK AYG + + N W LDF+IV V L S I ANALG
Sbjct: 170 FTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGA 229
Query: 1290 GA-IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1348
G +K+LR R LRPLR +S ++VV+N+++ A+ ++++ L+ L +I++I+G+ L
Sbjct: 230 GFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLEL 289
Query: 1349 FAGKYH-YCFNETSEIRFEIEDVNNKTECE-----KLMEGNNTEIRWKNVK---INFDNV 1399
F GK H C+N+ ED + E + G + W K NFDN
Sbjct: 290 FMGKMHKTCYNQEG---IAAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNF 346
Query: 1400 GAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLF 1459
L + Q T +GW D++Y D+ D + +IYFV II GSFF LNL
Sbjct: 347 AFAMLTVFQCITMEGWTDVLYWVNDAVGRD---------WPWIYFVTLIIIGSFFVLNLV 397
Query: 1460 IGVIIDNFNQQKKKFGGQDIFMTEEQKK 1487
+GV+ F+++++K + F +K+
Sbjct: 398 LGVLSGEFSKEREKAKARGDFQKLREKQ 425
Score = 124 bits (311), Expect = 9e-28
Identities = 79/248 (31%), Positives = 134/248 (54%), Gaps = 20/248 (8%)
Query: 759 ITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWN 818
+ + LNTL +A EH+ V N +FTAEM LK+ ++ YF +N
Sbjct: 527 VIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFN 586
Query: 819 IFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVG 873
FD F+V ++E L + + G+SVLR RLLR+FK+ + W +L+ L+ + NSV
Sbjct: 587 RFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVR 646
Query: 874 ALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFRVL 933
++ +L L+L + + IF+++GMQLFG + + + R +F S L VF++L
Sbjct: 647 SIASLLLLLFLFIIIFSLLGMQLFGGKFN------FDEMQTRRSTFDNFPQSLLTVFQIL 700
Query: 934 CGE-WIETMWDCM------EVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFS-ADNL 985
GE W M+D + G +C I F+++ + GN ++LN+FLA+ + + + A++L
Sbjct: 701 TGEDWNSVMYDGIMAYGGPSFPGMLVC-IYFIILFICGNYILLNVFLAIAVDNLADAESL 759
Query: 986 AATDDDGE 993
+ + E
Sbjct: 760 TSAQKEEE 767
Score = 115 bits (288), Expect = 4e-25
Identities = 81/308 (26%), Positives = 149/308 (48%), Gaps = 47/308 (15%)
Query: 711 ELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFM 770
EL+++QR+C K + + K+ +VN + + + + I+LNT+ +
Sbjct: 1178 ELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVN----STYFEYLMFVLILLNTICL 1233
Query: 771 AMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLM 830
AM+H+ + F+ + + N++FTG+FT EM LKLIA P YF + WN+FD IV S++
Sbjct: 1234 AMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSII 1293
Query: 831 ELSLADVE-------------------GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNS 871
++ L++ ++ R FR++R+ KL + L+ S
Sbjct: 1294 DVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKS 1353
Query: 872 VGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPRWHMHDFFHSFLIVFR 931
AL + L++ ++ FI+AV+GMQ+FGK +IN++ + F + L++FR
Sbjct: 1354 FQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNN-----NFQTFPQAVLLLFR 1408
Query: 932 VLCGE-WIETMWDCM------------------EVAGQAMCLIVFMMVMVIGNLVVLNLF 972
GE W + M CM G + + F+ ++ +++NLF
Sbjct: 1409 CATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLF 1468
Query: 973 LALLLSSF 980
+A+++ +F
Sbjct: 1469 VAVIMDNF 1476
Score = 102 bits (255), Expect = 3e-21
Identities = 96/424 (22%), Positives = 177/424 (41%), Gaps = 59/424 (13%)
Query: 1099 AVGESDFENLNT-----EDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEE 1153
A DF+ L ED+ D + +D + EG + KP +P + E
Sbjct: 412 AKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEE-KPRNMSMPTSETES 470
Query: 1154 YLDPDACFTEGCVQRFKCCQVNIEEGLGKS----WW-----ILRKTCFLIVEHNWFETFI 1204
+ G + C + + KS +W R+ C V+ N F +
Sbjct: 471 VNTENVA---GGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLV 527
Query: 1205 IFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAW 1264
IF++ L++ +A E + Q + + + A+K +F EMLLK + G +F + +
Sbjct: 528 IFLVFLNTLTIASE--HYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 585
Query: 1265 CWLD-FLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGA 1323
D F++ L +++ S LG I LR +R LR + + + +V +L+ +
Sbjct: 586 NRFDCFVVCGGILETILVETKIMSPLG-ISVLRCVRLLRIFKITRYWNSLSNLVASLLNS 644
Query: 1324 IPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIEDVNNKTECEKLMEGN 1383
+ SI ++LL+ +F +IFS++G+ LF GK+++ +T
Sbjct: 645 VRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR---------------------- 682
Query: 1384 NTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIY 1443
+ FDN L + Q+ T + W +MY + + P + + IY
Sbjct: 683 ---------RSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFP----GMLVCIY 729
Query: 1444 FVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKP 1503
F+I I G++ LN+F+ + +DN + Q EE+K+ + +K Q+
Sbjct: 730 FIILFICGNYILLNVFLAIAVDNLADAESLTSAQK--EEEEEKERKKLARTASPEKKQEL 787
Query: 1504 IPRP 1507
+ +P
Sbjct: 788 VEKP 791
Score = 89.7 bits (221), Expect = 2e-17
Identities = 103/439 (23%), Positives = 183/439 (41%), Gaps = 77/439 (17%)
Query: 15 KPFTPESLAN-IERRIAESKLKKPPKA----DGSHREDDEDSKPKPNSDL--EAGKSLPF 67
KP ES IE + + + PP D ++ED P PN + E + P
Sbjct: 790 KPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEP- 848
Query: 68 IYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIK 127
++P G PL + +L +K + A +I S N R +
Sbjct: 849 ---EMPVGPRPRPLSEL---HLKEKAVPM----------PEASAFFIFSSNNRFRLQCHR 892
Query: 128 ILIHSVFSMIIMCTILTNCVFMTFSNPPDWSK-------NVEYTFTGIYTFESLVKIIAR 180
I+ ++F+ +I+ IL + + + +P + + FT I+T E +K+ A
Sbjct: 893 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 952
Query: 181 GFCIDGFTFLRDPWNWLDFSVIMMAYITEFVN---LGNVSALRTFRVLRALKTISVIPGL 237
G + +F R+ +N LD V+ ++ I+ + + V LR RVLR L+ I+ GL
Sbjct: 953 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1012
Query: 238 KTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGT 297
K +V + +++ + +++I+T +FA IG+QLF G L + + + E
Sbjct: 1013 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL------YTCSDSSKQTEAEC 1066
Query: 298 KGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFS 357
KG YI K P +++P NS FD
Sbjct: 1067 KG----NYITYKDGEVDHP-IIQPRSWENSK----------------------FDFDNVL 1099
Query: 358 WAFLALFRLMTQDYWENLYQLTLRA----AGKTY------MIFFVLVIFVGSFYLVNLIL 407
A +ALF + T + W L ++ + G Y IFF++ I + +F+++N+ +
Sbjct: 1100 AAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFV 1159
Query: 408 AVVAMAYEEQNQATLEEAE 426
V + ++EQ + + E
Sbjct: 1160 GFVIVTFQEQGEQEYKNCE 1178
Score = 87.4 bits (215), Expect = 1e-16
Identities = 90/395 (22%), Positives = 168/395 (42%), Gaps = 91/395 (23%)
Query: 1482 TEEQKKYYNAMKKLGSKKPQKPIPRPL------NKIQGIVFDFVTQQAFDIVIMMLICLN 1535
T+ +++ Y KK GS +P PR L N I+ V + F+I+I++ I N
Sbjct: 79 TQRKRQQYGKPKKQGSTTATRP-PRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFAN 137
Query: 1536 MVTMMVET---DTQSKQMENILYWINLVFVIFFTCECVLKMFALR-----HYYFTIGWNI 1587
V + + + S + L + +F+I FT E LK+ A + Y GWN+
Sbjct: 138 CVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNL 197
Query: 1588 FDFVVVILSIVGMFLADIIEKYFVSPTL-----------FRVIRLARIGRILRLIKGAKG 1636
DF++V +VG+F A I+E+ + + +R R+ R LRL+ G
Sbjct: 198 LDFIIV---VVGLFSA-ILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPS 253
Query: 1637 IRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHE--------AGIDD---- 1684
++ +L +++ ++ L +I LL+ V+ I++I G+ F H+ A DD
Sbjct: 254 LQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIAAEDDPSPC 313
Query: 1685 --------------------------MFNFETFGNSMICLFQITTSAGWDGLLLPILNRP 1718
+ NF+ F +M+ +FQ T GW +L +
Sbjct: 314 ALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWV---- 369
Query: 1719 PDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESAD 1778
+ ++ ++ P +FV+ III V+N+ + ++ FS E++
Sbjct: 370 -NDAVGRDWPW--------------IYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAK- 413
Query: 1779 PLSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1813
+ DF+ E ++ + D ++++ A+ D
Sbjct: 414 --ARGDFQKLRE-KQQLEEDLKGYLDWITQAEDID 445
Score = 85.9 bits (211), Expect = 4e-16
Identities = 73/288 (25%), Positives = 137/288 (47%), Gaps = 25/288 (8%)
Query: 1519 VTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR- 1577
V F +++ L+ LN +T+ E Q + + N + FT E +LKM++L
Sbjct: 518 VKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGL 577
Query: 1578 HYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGI 1637
YF +N FD VV I+ L +E +SP V+R R+ RI ++ + +
Sbjct: 578 QAYFVSLFNRFDCFVVCGGILETIL---VETKIMSPLGISVLRCVRLLRIFKITRYWNSL 634
Query: 1638 RTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDM----FNFETFGN 1693
L+ +L+ S+ ++ ++ LLLFL + IFS+ GM F + D+M F+ F
Sbjct: 635 SNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG---GKFNFDEMQTRRSTFDNFPQ 691
Query: 1694 SMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIIS 1753
S++ +FQI T W+ ++ + + G F G V I+F + +I +
Sbjct: 692 SLLTVFQILTGEDWNSVMYDGI---------MAYGGPSFPG----MLVCIYFIILFICGN 738
Query: 1754 FLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQ 1801
+ I++N+++AI ++N + A ++ E++ + ++ P+ Q
Sbjct: 739 Y-ILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQ 785
Score = 82.8 bits (203), Expect = 3e-15
Identities = 73/295 (24%), Positives = 132/295 (44%), Gaps = 61/295 (20%)
Query: 746 VNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL-----VFTGIFTAEM 800
++++ PF ++ I + I N + +A+ + P+ + NL +F IFT E
Sbjct: 118 ISIVEWKPF-EIIILLTIFANCVALAI--YIPFPEDDSNATNSNLERVEYLFLIIFTVEA 174
Query: 801 FLKLIA----MDPYYYFQEGWNIFDGFIVSLSLMELSLADVE---------------GLS 841
FLK+IA P Y + GWN+ D IV + L L +
Sbjct: 175 FLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVK 234
Query: 842 VLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKS 900
LR+FR+LR +L P+L +++ I ++ L ++ L++ ++ I+A++G++LF GK
Sbjct: 235 ALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKM 294
Query: 901 YKECV-----------------------CKINQDCELPRW--------HMHDFFHSFLIV 929
+K C C+ C+ P W + +F + L V
Sbjct: 295 HKTCYNQEGIAAEDDPSPCALETGHGRQCQNGTVCK-PGWDGPKHGITNFDNFAFAMLTV 353
Query: 930 FRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 983
F+ + E W + ++ + G+ I F+ +++IG+ VLNL L +L FS +
Sbjct: 354 FQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKE 408
Score = 68.2 bits (165), Expect = 8e-11
Identities = 47/161 (29%), Positives = 84/161 (52%), Gaps = 8/161 (4%)
Query: 749 IVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFE-HVLAVGNLVFTGIFTAEMFLKLIAM 807
IV D I I+L+++ +A E F H+L ++VFT IFT E+ LK+ A
Sbjct: 893 IVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAY 952
Query: 808 DPYY----YFQEGWNIFDGFIVSLSLMELSLAD--VEGLSVLRSFRLLRVFKLAKSWPTL 861
+ + + +NI D +VS+SL+ + + + +LR R+LR + L
Sbjct: 953 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGL 1012
Query: 862 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF-GKSY 901
+++ + ++ +GN+ +V ++ F+FA +G+QLF GK Y
Sbjct: 1013 KHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLY 1053
Score = 58.9 bits (141), Expect = 5e-08
Identities = 38/129 (29%), Positives = 67/129 (51%), Gaps = 24/129 (18%)
Query: 165 FTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYITEFVNLGN--------- 215
FTG++T E ++K+IA F G+ DPWN DF +++ + I ++ N
Sbjct: 1255 FTGLFTVEMILKLIA--FKPKGY--FSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSP 1310
Query: 216 -----------VSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 264
++ R FRV+R +K +S G++T++ I+S + L V +L V +
Sbjct: 1311 SMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1370
Query: 265 FALIGLQLF 273
+A+IG+Q+F
Sbjct: 1371 YAVIGMQVF 1379
Score = 51.2 bits (121), Expect = 1e-05
Identities = 55/240 (22%), Positives = 99/240 (41%), Gaps = 52/240 (21%)
Query: 123 RIAIKILIHSVFSMIIMCTILTNCVFMTFS--NPPDWSKNVEYT----FTGIYTFESLVK 176
R A+K +VF +++ + N + + N P+W V+ T ++T E L+K
Sbjct: 515 RAAVK---SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLK 571
Query: 177 IIARGFCIDGFTFLRDPWNWLDFSVIMMAYI------TEFVNLGNVSALRTFRVLRALKT 230
+ + G + +N D V+ + T+ ++ +S LR R+LR K
Sbjct: 572 MYSLGLQ----AYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 627
Query: 231 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNE 290
L +V +L+ SV+ ++ +++L + +F+L+G+QLF G NF+E
Sbjct: 628 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGK---------FNFDE 678
Query: 291 SYLENGT---------------KGFDWEEYINNKTNFY---TVPGMLEPL------LCGN 326
T G DW + + Y + PGML + +CGN
Sbjct: 679 MQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGN 738
Score = 50.4 bits (119), Expect = 2e-05
Identities = 47/197 (23%), Positives = 89/197 (45%), Gaps = 21/197 (10%)
Query: 351 TSFDTFSWAFLALFRLMTQDYWEN-LYQLTLRAAGKTY-----MIFFVLVIFVGSFYLVN 404
++FD F + L +F+++T + W + +Y + G ++ I+F+++ G++ L+N
Sbjct: 684 STFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLN 743
Query: 405 LILAVVA---MAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSED 461
+ LA+ E A EE E+KE + A +K+QE + A+ G E+
Sbjct: 744 VFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAV----GESKEE 799
Query: 462 AIEEEGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEE-KGDPEKVF---- 516
IE + G S +K++ + N K + GEE + +PE
Sbjct: 800 KIELKSITADG---ESPPATKINMDDLQPNENEDKSPYPNPETTGEEDEEEPEMPVGPRP 856
Query: 517 KSESEDGMRRKAFRLPD 533
+ SE ++ KA +P+
Sbjct: 857 RPLSELHLKEKAVPMPE 873
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,171,673
Number of Sequences: 37866
Number of extensions: 3294055
Number of successful extensions: 22503
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 169
Number of HSP's successfully gapped in prelim test: 325
Number of HSP's that attempted gapping in prelim test: 15006
Number of HSP's gapped (non-prelim): 4428
length of query: 1980
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1863
effective length of database: 13,817,196
effective search space: 25741436148
effective search space used: 25741436148
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.