Search of human proteins with 7657301

Search of human proteins with 7657301

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657301 kelch domain containing 2 [Homo sapiens]
         (406 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657301 kelch domain containing 2 [Homo sapiens]                   875   0.0  
gi|26190616 kelch domain containing 1 [Homo sapiens]                  348   6e-96
gi|7019405 host cell factor C2 [Homo sapiens]                          96   6e-20
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]     90   3e-18
gi|98986457 host cell factor 1 [Homo sapiens]                          89   9e-18
gi|16945972 kelch domain containing 3 [Homo sapiens]                   84   3e-16
gi|21314675 kelch domain containing 4 [Homo sapiens]                   82   9e-16
gi|44917619 kelch domain containing 10 [Homo sapiens]                  80   3e-15
gi|62955044 F-box protein 42 [Homo sapiens]                            72   1e-12
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ...    71   2e-12
gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]                47   4e-05
gi|55956888 kelch/ankyrin repeat containing cyclin A1 interactin...    44   3e-04
gi|8922640 kelch domain containing 8A [Homo sapiens]                   42   0.001
gi|55925604 kelch-like 18 [Homo sapiens]                               40   0.005
gi|45643138 kelch-like 13 [Homo sapiens]                               39   0.006
gi|24308181 kelch-like 9 [Homo sapiens]                                38   0.014
gi|25188199 leucine carboxyl methyltransferase 2 [Homo sapiens]        36   0.055
gi|40255071 kelch-like 23 [Homo sapiens]                               36   0.071
gi|158508542 kelch-like 33 [Homo sapiens]                              35   0.16 
gi|31881798 muskelin 1, intracellular mediator containing kelch ...    34   0.21 
gi|223890246 muskelin 1, intracellular mediator containing kelch...    34   0.21 
gi|55956892 kelch/ankyrin repeat containing cyclin A1 interactin...    34   0.21 
gi|156616301 kelch-like 32 [Homo sapiens]                              34   0.21 
gi|14780904 kelch-like 1 protein [Homo sapiens]                        34   0.27 
gi|194097389 kelch-like 38 [Homo sapiens]                              33   0.35 
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                      33   0.46 
gi|40807500 kelch-like 20 [Homo sapiens]                               33   0.46 
gi|24432026 kelch-like [Homo sapiens]                                  33   0.60 
gi|55749726 kelch domain containing 5 [Homo sapiens]                   32   1.0  
gi|24475847 influenza virus NS1A binding protein [Homo sapiens]        32   1.0  

>gi|7657301 kelch domain containing 2 [Homo sapiens]
          Length = 406

 Score =  875 bits (2261), Expect = 0.0
 Identities = 406/406 (100%), Positives = 406/406 (100%)

Query: 1   MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYD 60
           MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYD
Sbjct: 1   MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYD 60

Query: 61  FYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYM 120
           FYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYM
Sbjct: 61  FYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYM 120

Query: 121 LDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDET 180
           LDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDET
Sbjct: 121 LDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDET 180

Query: 181 SFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDA 240
           SFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDA
Sbjct: 181 SFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDA 240

Query: 241 RMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY 300
           RMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY
Sbjct: 241 RMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY 300

Query: 301 CISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQ 360
           CISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQ
Sbjct: 301 CISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQ 360

Query: 361 PKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS 406
           PKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS
Sbjct: 361 PKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS 406


>gi|26190616 kelch domain containing 1 [Homo sapiens]
          Length = 406

 Score =  348 bits (892), Expect = 6e-96
 Identities = 173/374 (46%), Positives = 235/374 (62%), Gaps = 9/374 (2%)

Query: 25  ELACPAE-RSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINT 83
           +L C AE RSGH AV DG  ++VWGGY S +     + YLP +E+W Y++++G W+    
Sbjct: 5   QLFCVAEERSGHCAVVDGNFLYVWGGYVSIEDN---EVYLPNDEIWTYDIDSGLWRMHLM 61

Query: 84  EGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERI-DCQGIPP 142
           EG++P SMSGSC  C++  LY+FGG+  +G +N+ Y ++ R+ D    WE+I D +G PP
Sbjct: 62  EGELPASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPP 121

Query: 143 SSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTET 202
           + +DKL  WVYK++LI+FGGYG     ++   F+  + S W      GW++ VHI DT+T
Sbjct: 122 TPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDAS-WEEQIFWGWHNDVHIFDTKT 180

Query: 203 FTWSQP-ITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIP- 260
            TW QP I  G  P PRAAH CA +GN+G++FGGR    RMNDLHYLNLDTW W+  I  
Sbjct: 181 QTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITI 240

Query: 261 QGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRL 320
            G  P  RSWH+LTP++ D LFL GG + D  PLSD W + ++ N W Q  H    +PRL
Sbjct: 241 NGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKTRPRL 300

Query: 321 WHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVICFKEMLA 380
           WHTAC   E E++VFGG  ++LL      H N++LIF  QP SL+R  L+ +     ML 
Sbjct: 301 WHTACLGKENEIMVFGGSKDDLLALD-TGHCNDLLIFQTQPYSLLRSCLDCIGKNSIMLE 359

Query: 381 NSWNCLPKHLLHSV 394
           +  + LP  LL  V
Sbjct: 360 SQISLLPPKLLQQV 373


>gi|7019405 host cell factor C2 [Homo sapiens]
          Length = 792

 Score = 95.9 bits (237), Expect = 6e-20
 Identities = 81/277 (29%), Positives = 123/277 (44%), Gaps = 43/277 (15%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
           P  R GH AV+    M ++GG       G+ D      EL +YN  T +W      GD+P
Sbjct: 20  PRARHGHRAVAIRELMIIFGGGNE----GIAD------ELHVYNTATNQWFLPAVRGDIP 69

Query: 89  PSMSGSCAVCVDRVLYLFGGHHSRGN-TNKFYMLDSRSTDRVLQWERI----DCQGIPPS 143
           P  +    VC    + +FGG    G  +N+ Y L +    R L W+++       G+PP 
Sbjct: 70  PGCAAHGFVCDGTRILVFGGMVEYGRYSNELYELQA---SRWL-WKKVKPHPPPSGLPPC 125

Query: 144 SKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHI---LDT 200
            +      +Y NK   FGG     ED              N++ PR  ND   +     +
Sbjct: 126 PRLGHSFSLYGNKCYLFGGLANESEDS-------------NNNVPRYLNDFYELELQHGS 172

Query: 201 ETFTWSQPITTGKAPSPRAAHACATVGNRG------FVFGGRYRDARMNDLHYLNLDTWE 254
               WS P+T G  PSPR +H       +       +VFGG    AR++DL  L+L+T  
Sbjct: 173 GVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMC-GARLDDLWQLDLETMS 231

Query: 255 WNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDK 291
           W++   +G  P+ RS H+ + V  + +++FGG+   K
Sbjct: 232 WSKPETKGTVPLPRSLHTAS-VIGNKMYIFGGWVPHK 267



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 24/171 (14%)

Query: 190 GWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDAR-MNDLHYL 248
           G  D +H+ +T T  W  P   G  P   AAH     G R  VFGG     R  N+L+ L
Sbjct: 44  GIADELHVYNTATNQWFLPAVRGDIPPGCAAHGFVCDGTRILVFGGMVEYGRYSNELYEL 103

Query: 249 NLDTWEWNEL----IPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISK 304
               W W ++     P G+ P  R  HS + +  +  +LFGG   + +  ++     ++ 
Sbjct: 104 QASRWLWKKVKPHPPPSGLPPCPRLGHSFS-LYGNKCYLFGGLANESEDSNNNVPRYLND 162

Query: 305 NEWIQFNH---------PYTE----KPRLWHTA---CASDEG--EVIVFGG 337
              ++  H         P T+     PR  HTA   C  D G  ++ VFGG
Sbjct: 163 FYELELQHGSGVVGWSIPVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGG 213



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 64/252 (25%), Positives = 92/252 (36%), Gaps = 49/252 (19%)

Query: 29  PAERSGHVAVSDGRHMFVWGGY-------KSNQVRGLYDFYLPREELWI-YNMETGRWKK 80
           P  R GH     G   +++GG         +N  R L DFY    EL + +      W  
Sbjct: 124 PCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFY----ELELQHGSGVVGWSI 179

Query: 81  INTEGDVPPSMSGSCAVCVDRV------LYLFGGHHSRGNTNKFYMLDSRSTDRVLQWER 134
             T+G VP       AV   +       +Y+FGG       +  + LD  +    + W +
Sbjct: 180 PVTKGVVPSPRESHTAVIYCKKDSGSPKMYVFGGMCG-ARLDDLWQLDLET----MSWSK 234

Query: 135 IDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWN-- 192
            + +G  P  +      V  NK+  FGG+       V    E  ETS     H   W   
Sbjct: 235 PETKGTVPLPRSLHTASVIGNKMYIFGGW-------VPHKGENTETS----PHDCEWRCT 283

Query: 193 DHVHILDTETFTW------SQPITTGKAPSPRAAHACATVGNRGFVFGGR--YRDAR--- 241
                L+ +T  W      SQ       P PRA H    +G R + + GR  Y+ A    
Sbjct: 284 SSFSYLNLDTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRDGYKKALNSQ 343

Query: 242 --MNDLHYLNLD 251
               DL YL+ +
Sbjct: 344 VCCKDLWYLDTE 355


>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
          Length = 372

 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 76/292 (26%), Positives = 116/292 (39%), Gaps = 46/292 (15%)

Query: 70  IYNMETGR--WKKINTEGDVPPSMSGS-CAVCVDRVLYLFGGHHSRGNTNKFYMLDSRST 126
           ++ M+ G+  W     +G +P     S    C    +++FGG +  GN N   +L+  + 
Sbjct: 65  VHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETR 124

Query: 127 DRVLQWERIDCQGIPPSSKD-KLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 185
                W   +    PPS +          N+L  FGG G      V  T           
Sbjct: 125 T----WTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVQDT----------- 168

Query: 186 SHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDL 245
                    +H+ D  T TWSQP T G  PSPR  H     G + F+ GG   D   +DL
Sbjct: 169 --------KLHVFDANTLTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDL 220

Query: 246 HYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKN 305
           H +++   +W +L P G  P G + HS   +   H+++FGG  T    L   + Y   + 
Sbjct: 221 HCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGK-HVYIFGGM-TPAGALDTMYQYHTEEQ 278

Query: 306 EWIQFNHPYTEKP-RL--------WHTACASDEGEVIVFGGCANNLLVHHRA 348
            W          P RL        W   CAS++ +       +N+L ++H A
Sbjct: 279 HWTLLKFDTLLPPGRLDHSMCIIPWPVTCASEKED-------SNSLTLNHEA 323



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 51/214 (23%), Positives = 82/214 (38%), Gaps = 33/214 (15%)

Query: 65  REELWIYNMETGRWKKINTEGDVP-PSMSGSCAVCVDRVLYLFGGHHSRG----NTNKFY 119
           R  L + N ET  W         P P    + +  +   LY+FGG   RG       K +
Sbjct: 113 RNCLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGGGE-RGAQPVQDTKLH 171

Query: 120 MLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDE 179
           + D+ +    L W + +  G PPS +    +     KL   GG   L  D+         
Sbjct: 172 VFDANT----LTWSQPETLGNPPSPRHGHVMVAAGTKLFIHGG---LAGDR--------- 215

Query: 180 TSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRD 239
                      + D +H +D     W +   TG AP+  AAH+   +G   ++FGG    
Sbjct: 216 -----------FYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPA 264

Query: 240 ARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSL 273
             ++ ++  + +   W  L    + P GR  HS+
Sbjct: 265 GALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSM 298



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 26/91 (28%), Positives = 45/91 (49%), Gaps = 9/91 (9%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
           P+ R GHV V+ G  +F+ GG   ++      FY   ++L   ++   +W+K+N  G  P
Sbjct: 190 PSPRHGHVMVAAGTKLFIHGGLAGDR------FY---DDLHCIDISDMKWQKLNPTGAAP 240

Query: 89  PSMSGSCAVCVDRVLYLFGGHHSRGNTNKFY 119
              +   AV + + +Y+FGG    G  +  Y
Sbjct: 241 AGCAAHSAVAMGKHVYIFGGMTPAGALDTMY 271



 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 38/149 (25%), Positives = 63/149 (42%), Gaps = 23/149 (15%)

Query: 204 TWSQPITTGKAPSPRAAHACA---TVGN--RG--FVFGGRYRDARMNDLHYLNLDTWEWN 256
           TW      G +P  R  H+C+    VGN  RG  F+ GG   +   +D+H ++L   +W+
Sbjct: 17  TWYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWD 76

Query: 257 ELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTD--------KQPLSDAWTYCISKNEWI 308
               +G+ P       +   + D +++FGG              P +  WT         
Sbjct: 77  LDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPETRTWT-------TP 129

Query: 309 QFNHPYTEKPRLWHTACASDEGEVIVFGG 337
           +   P    PR +HT+ A+   ++ VFGG
Sbjct: 130 EVTSP-PPSPRTFHTSSAAIGNQLYVFGG 157


>gi|98986457 host cell factor 1 [Homo sapiens]
          Length = 2035

 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 77/273 (28%), Positives = 113/273 (41%), Gaps = 43/273 (15%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
           P  R GH AV+    + V+GG     V          +EL +YN  T +W      GD+P
Sbjct: 30  PRPRHGHRAVAIKELIVVFGGGNEGIV----------DELHVYNTATNQWFIPAVRGDIP 79

Query: 89  PSMSGSCAVCVDRVLYLFGGHHSRGN-TNKFYMLDSRSTDRVLQWERIDCQ----GIPPS 143
           P  +    VC    L +FGG    G  +N  Y L +   +    W+R+  +    G PP 
Sbjct: 80  PGCAAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWE----WKRLKAKTPKNGPPPC 135

Query: 144 SKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTE-- 201
            +      +  NK   FGG     ED               ++ PR  ND ++IL+    
Sbjct: 136 PRLGHSFSLVGNKCYLFGGLANDSEDP-------------KNNIPRYLND-LYILELRPG 181

Query: 202 --TFTWSQPITTGKAPSPRAAHACATVGNRG-----FVFGGRYRDARMNDLHYLNLDTWE 254
                W  PIT G  P PR +H       +       V  G     R+ DL  L++DT  
Sbjct: 182 SGVVAWDIPITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLGDLWTLDIDTLT 241

Query: 255 WNELIPQGICPVGRSWHSLTPVSSDHLFLFGGF 287
           WN+    G+ P+ RS HS T +  + +++FGG+
Sbjct: 242 WNKPSLSGVAPLPRSLHSATTI-GNKMYVFGGW 273



 Score = 68.9 bits (167), Expect = 8e-12
 Identities = 74/287 (25%), Positives = 111/287 (38%), Gaps = 73/287 (25%)

Query: 38  VSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWK------KINTEGDVPPSM 91
           V DG  + V+GG       G Y   L       Y ++  RW+      K    G  P   
Sbjct: 88  VCDGTRLLVFGGMVEY---GKYSNDL-------YELQASRWEWKRLKAKTPKNGPPPCPR 137

Query: 92  SGSCAVCVDRVLYLFGG-----HHSRGNT----NKFYMLDSRSTDRVLQWERIDCQGIPP 142
            G     V    YLFGG        + N     N  Y+L+ R    V+ W+     G+ P
Sbjct: 138 LGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYGVLP 197

Query: 143 SSKDKLGVWVY------KNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVH 196
             ++     VY      K+KL+ +GG         LG         W             
Sbjct: 198 PPRESHTAVVYTEKDNKKSKLVIYGGMSGCR----LG-------DLWT------------ 234

Query: 197 ILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGG----RYRDARM---------- 242
            LD +T TW++P  +G AP PR+ H+  T+GN+ +VFGG       D ++          
Sbjct: 235 -LDIDTLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCT 293

Query: 243 NDLHYLNLDTWEWNELIPQGI---CPVGRSWHSLTPVSSDHLFLFGG 286
           N L  LNLDT  W  ++   +    P  R+ H    +++  L+++ G
Sbjct: 294 NTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINT-RLYIWSG 339



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 55/245 (22%), Positives = 86/245 (35%), Gaps = 38/245 (15%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGR----WKKINTE 84
           P  R GH     G   +++GG  ++      +      +L+I  +  G     W    T 
Sbjct: 134 PCPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITY 193

Query: 85  GDVPPSMSGSCAVCVDRV------LYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQ 138
           G +PP      AV           L ++GG  S       + LD  +    L W +    
Sbjct: 194 GVLPPPRESHTAVVYTEKDNKKSKLVIYGGM-SGCRLGDLWTLDIDT----LTWNKPSLS 248

Query: 139 GIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGW--NDHVH 196
           G+ P  +         NK+  FGG+  L  D V             ++H + W   + + 
Sbjct: 249 GVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVK-----------VATHEKEWKCTNTLA 297

Query: 197 ILDTETFTWS---QPITTGKAPSPRAAHACATVGNRGFVFGGR--YRDARMN-----DLH 246
            L+ +T  W            P  RA H    +  R +++ GR  YR A  N     DL 
Sbjct: 298 CLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDLW 357

Query: 247 YLNLD 251
           YL  +
Sbjct: 358 YLETE 362



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 40/166 (24%), Positives = 68/166 (40%), Gaps = 15/166 (9%)

Query: 205 WSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGIC 264
           WS P+     P PR  H    +     VFGG   +  +++LH  N  T +W     +G  
Sbjct: 25  WSGPV-----PRPRHGHRAVAIKELIVVFGGG-NEGIVDELHVYNTATNQWFIPAVRGDI 78

Query: 265 PVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEK-----PR 319
           P G + +         L +FGG     +  +D +    S+ EW +      +      PR
Sbjct: 79  PPGCAAYGFV-CDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPR 137

Query: 320 LWHTACASDEGEVIVFGGCANNL--LVHHRAAHSNEILIFSVQPKS 363
           L H+       +  +FGG AN+     ++   + N++ I  ++P S
Sbjct: 138 LGHSFSLVG-NKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGS 182



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 26/94 (27%), Positives = 45/94 (47%), Gaps = 8/94 (8%)

Query: 23  SMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPRE-----ELWIYNMETGR 77
           S+    P  RS H A + G  M+V+GG+    +  +      +E      L   N++T  
Sbjct: 246 SLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTMA 305

Query: 78  WKKI---NTEGDVPPSMSGSCAVCVDRVLYLFGG 108
           W+ I     E ++P + +G CAV ++  LY++ G
Sbjct: 306 WETILMDTLEDNIPRARAGHCAVAINTRLYIWSG 339


>gi|16945972 kelch domain containing 3 [Homo sapiens]
          Length = 382

 Score = 83.6 bits (205), Expect = 3e-16
 Identities = 101/403 (25%), Positives = 158/403 (39%), Gaps = 72/403 (17%)

Query: 32  RSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPRE-ELWIYNMETGRWKK-------INT 83
           R  H AV+ G  ++ +GGY S +     D+   R+ ++ I+N  + RW K       I  
Sbjct: 14  RVNHAAVAVGHRVYSFGGYCSGE-----DYETLRQIDVHIFNAVSLRWTKLPPVKSAIRG 68

Query: 84  EGDVPPSMS-GSCAVCVDRVLYLFGGHH-SRGNTNKFYMLDSRSTDRVLQWERIDCQGIP 141
           +  V P M  G   V +D  + L+GG + + G  N  Y  D  +     +W      G  
Sbjct: 69  QAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTH----KWFTPRVSGTV 124

Query: 142 PSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTE 201
           P ++D     V    +  FGGY            E     F N          +H LDT 
Sbjct: 125 PGARDGHSACVLGKIMYIFGGY------------EQQADCFSND---------IHKLDTS 163

Query: 202 TFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGR---------YRDARMNDLHYLNLDT 252
           T TW+   T G     R  H+   +G+  +VFGGR           +   N +   +  T
Sbjct: 164 TMTWTLICTKGSPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRT 223

Query: 253 WEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTD-KQPLSDAWTYCISKNEWIQFN 311
             W +  P  + P GR  HS    + + L++FGG+     +   D W +      W +  
Sbjct: 224 EAWLDCPPTPVLPEGRRSHSAFGYNGE-LYIFGGYNARLNRHFHDLWKFNPVSFTWKKI- 281

Query: 312 HPYTEKPRLWHTACASDEGE-VIVFGGCANNL---------LVHHRAAHSNEILIFSVQP 361
            P  + P      C    G+ +++FGG + +          L+ H   H   IL FS   
Sbjct: 282 EPKGKGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLH---ILDFSPSL 338

Query: 362 KSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTS 404
           K+L +L   AVI +        +CLP  +   +N    ++N S
Sbjct: 339 KTLCKL---AVIQYN----LDQSCLPHDIRWELNAMTTNSNIS 374



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 56/217 (25%), Positives = 81/217 (37%), Gaps = 43/217 (19%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
           P  R GH A   G+ M+++GGY+        D +    ++   +  T  W  I T+G   
Sbjct: 125 PGARDGHSACVLGKIMYIFGGYEQQA-----DCF--SNDIHKLDTSTMTWTLICTKGSPA 177

Query: 89  PSMSGSCAVCVDRVLYLFGGHHSR----GNTNKFYMLDSRSTD-RVLQWERIDCQGIP-- 141
                  A  +   +Y+FGG   R     + N+ Y    R  D R   W  +DC   P  
Sbjct: 178 RWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAW--LDCPPTPVL 235

Query: 142 PSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHIL--- 198
           P  +     + Y  +L  FGGY                            N H H L   
Sbjct: 236 PEGRRSHSAFGYNGELYIFGGYN------------------------ARLNRHFHDLWKF 271

Query: 199 DTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGG 235
           +  +FTW +    GK P PR    C  VG++  +FGG
Sbjct: 272 NPVSFTWKKIEPKGKGPCPRRRQCCCIVGDKIVLFGG 308


>gi|21314675 kelch domain containing 4 [Homo sapiens]
          Length = 520

 Score = 82.0 bits (201), Expect = 9e-16
 Identities = 82/333 (24%), Positives = 134/333 (40%), Gaps = 63/333 (18%)

Query: 22  ESMELACPAERSGHVAVSDGRH-----MFVWGG-YKSNQVRGLYDFYLPREELWIYNMET 75
           +++EL CP   S  +  S   H     + ++GG Y + Q   LY+      EL++YN   
Sbjct: 52  QTVELPCPPP-SPRLNASLSVHPEKDELILFGGEYFNGQKTFLYN------ELYVYNTRK 104

Query: 76  GRWKKINTEGDVPPSMSGSCAVCVDR---VLYLFGGHHSRGNTNKFYMLDSRSTDRVLQ- 131
             W K++     PP      AV V +    L++FGG  +  N  +FY         +   
Sbjct: 105 DTWTKVDIPSP-PPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHYKDLWVLHLATK 163

Query: 132 -WERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRG 190
            WE++   G  PS +    +  +K +LI FGG+     D +                   
Sbjct: 164 TWEQVKSTG-GPSGRSGHRMVAWKRQLILFGGFHESTRDYIY------------------ 204

Query: 191 WNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRY----------RDA 240
           +ND V+  + +TFTWS+   +G  P+PR+    +     G V  G Y          +  
Sbjct: 205 YND-VYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGT 263

Query: 241 RMNDLHYL-----NLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQP-- 293
           R +D+  L       D W W  + P G+ P  RS  S+    +     FGG   +++   
Sbjct: 264 RHSDMFLLKPEDGREDKWVWTRMNPSGVKPTPRSGFSVAMAPNHQTLFFGGVCDEEEEES 323

Query: 294 -----LSDAWTYCISKNEWI--QFNHPYTEKPR 319
                 +D + Y  ++N W   Q   P +EK +
Sbjct: 324 LSGEFFNDLYFYDATRNRWFEGQLKGPKSEKKK 356


>gi|44917619 kelch domain containing 10 [Homo sapiens]
          Length = 442

 Score = 80.1 bits (196), Expect = 3e-15
 Identities = 73/301 (24%), Positives = 119/301 (39%), Gaps = 50/301 (16%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRG----LYDFYLPREELWIYNMETGRWKKINTE 84
           P  RSGH  V+D  +++V+GGY  +          D+ L RE LW Y+  TG W ++ T+
Sbjct: 89  PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRE-LWRYHFATGVWHQMGTD 147

Query: 85  GDVPPSMSGSCAVCVDRVLYLFGGH---HSRGNTNKFYMLDSRSTDRVLQWERIDCQGIP 141
           G +P  ++    V     L +FGG        N N  ++ + +      +W  + C+G  
Sbjct: 148 GYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYK----RWALLSCRGKK 203

Query: 142 PSSKDKLGVWVYKNKLIFFGGY-GY---------------------------LPEDKVLG 173
           PS      + +    L  FGG  GY                           LPE++   
Sbjct: 204 PSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRH 263

Query: 174 TFEFDETSFWNSSHPRGWNDH----VHILDTETFTWSQPITTGKA----PSPRAAHACAT 225
               D    +       W  +    +H  + ET  W +  T        P+ R  H+C  
Sbjct: 264 EIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQ 323

Query: 226 VGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFG 285
           + N  F+ GG   +  + D+  LNL T++W +L      PV     ++TP     +++ G
Sbjct: 324 IKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGC--MYIHG 381

Query: 286 G 286
           G
Sbjct: 382 G 382



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 37/266 (13%)

Query: 88  PPSMSGSCAVCVDRVLYLFGGHH-----SRGNTNKFYMLDS---RSTDRVLQWERIDCQG 139
           PP+ SG   V  +  LY+FGG++     S G  N+ Y L     R       W ++   G
Sbjct: 89  PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148

Query: 140 IPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILD 199
             P     + + ++ N L+ FGG G            F E++           + VH+ +
Sbjct: 149 YMPRELASMSLVLHGNNLLVFGGTG----------IPFGESN----------GNDVHVCN 188

Query: 200 TETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELI 259
            +   W+     GK PS     A A +    +VFGG        DLH L+L+T EW +L 
Sbjct: 189 VKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLK 248

Query: 260 PQGI---CPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTE 316
           P  +    P  R  H +         L GG +     L+    Y +  N W +      E
Sbjct: 249 PNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHE 308

Query: 317 K-----PRLWHTACASDEGEVIVFGG 337
           K      R  H +C   + +V + GG
Sbjct: 309 KIGFPAARRCH-SCVQIKNDVFICGG 333



 Score = 30.4 bits (67), Expect = 3.0
 Identities = 30/139 (21%), Positives = 51/139 (36%), Gaps = 15/139 (10%)

Query: 213 KAPSPRAAHACATVGNRGFVFGGRYRD------------ARMNDLHYLNLDTWEWNELIP 260
           + P  R+ H C       +VFGG   D                +L   +  T  W+++  
Sbjct: 87  RPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGT 146

Query: 261 QGICPVGRSWHSLTPVSSDHLFLFG--GFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKP 318
            G  P   +  SL  +  ++L +FG  G    +   +D     +    W   +    +  
Sbjct: 147 DGYMPRELASMSLV-LHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPS 205

Query: 319 RLWHTACASDEGEVIVFGG 337
           R++  A A   G + VFGG
Sbjct: 206 RIYGQAMAIINGSLYVFGG 224


>gi|62955044 F-box protein 42 [Homo sapiens]
          Length = 717

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 60/241 (24%), Positives = 93/241 (38%), Gaps = 28/241 (11%)

Query: 94  SCAVCVDRVLYLFGG---HHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGV 150
           +C    ++ +Y+FGG          N  + LD  S +    W R    G  PS K    +
Sbjct: 124 ACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKE----WIRPLASGSYPSPKAGATL 179

Query: 151 WVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPIT 210
            VYK+ L+ FGG+                 S +    P  + D +H        W+  +T
Sbjct: 180 VVYKDLLVLFGGW--------------TRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVT 225

Query: 211 TGKAPSPRAAHACATVGNRGFVFGGRYRDARM-NDLHYLNLDTWEWNELIPQGICPVGRS 269
           T   P P A H+   + ++  VFGG     +M ND+  L+L+ W W++    G  P  R 
Sbjct: 226 T-HGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRG 284

Query: 270 WHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW----IQFNHPYTEKPRLW-HTA 324
             S   +    + + GG         DAW   +    W    ++  +     P LW H A
Sbjct: 285 GQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPA 344

Query: 325 C 325
           C
Sbjct: 345 C 345



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 49/150 (32%), Positives = 72/150 (48%), Gaps = 18/150 (12%)

Query: 201 ETFTWSQPITTGKAPSPRAAH-ACATVGNRG-FVFGGRYR---DARMNDLHYLNLDTWEW 255
           E+ T+  P   G   + R +H AC    N+  +VFGG  +   +A  NDL  L+L++ EW
Sbjct: 105 ESRTYPYP---GTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEW 161

Query: 256 NELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDK-----QP---LSDAWTYCISKNEW 307
              +  G  P  ++  +L  V  D L LFGG+T        QP     +  TY  SKN W
Sbjct: 162 IRPLASGSYPSPKAGATLV-VYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWW 220

Query: 308 IQFNHPYTEKPRLWHTACASDEGEVIVFGG 337
                 +   P   H++C  D+ ++IVFGG
Sbjct: 221 NCIVTTHGPPPMAGHSSCVIDD-KMIVFGG 249



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 48/227 (21%), Positives = 82/227 (36%), Gaps = 44/227 (19%)

Query: 44  MFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVL 103
           M+V+GG   +     ++      +LW  ++ +  W +    G  P   +G+  V    +L
Sbjct: 133 MYVFGGCTQSSCNAAFN------DLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLL 186

Query: 104 YLFGGH-----HSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLI 158
            LFGG      +      +F+      +     W  I     PP         V  +K+I
Sbjct: 187 VLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSC-VIDDKMI 245

Query: 159 FFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPR 218
            FGG                      S   R  ++ V +LD E + WS+P  +G +P PR
Sbjct: 246 VFGG----------------------SLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPR 283

Query: 219 AAHACATVGNRG-FVFGG------RYRDARMNDLHYLNLDTWEWNEL 258
              +   + +    + GG       ++DA +  +H      W W  L
Sbjct: 284 GGQSQIVIDDATILILGGCGGPNALFKDAWLLHMH---SGPWAWQPL 327


>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
           sapiens]
          Length = 840

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 78/321 (24%), Positives = 119/321 (37%), Gaps = 34/321 (10%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVP 88
           PA R  H AV  G  MFV+GGY  +           + +L+ Y   TG+W +   EG +P
Sbjct: 115 PAPRYHHSAVVYGSSMFVFGGYTGDIYSN--SNLKNKNDLFEYKFATGQWTEWKIEGRLP 172

Query: 89  PSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQ-WERIDCQGIPPSSKDK 147
            + S   A      L++F G+      N  + +  +  DR L  WE +   G  P S   
Sbjct: 173 VARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQ--DRELTCWEEVAQSGEIPPSCCN 230

Query: 148 LGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQ 207
             V V ++K+  F G         L  FEF + ++               + TE      
Sbjct: 231 FPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTR-------------IPTEHLLRGS 277

Query: 208 PITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVG 267
           P      P  R  H         +VFGG   +   N+LH  ++D   W  + P     VG
Sbjct: 278 P----PPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVG 333

Query: 268 RSWHSLTPVSSDHLFLFG-----GFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKP--RL 320
            +       +S+ +         GF   +    D +          Q   P +E P  RL
Sbjct: 334 GAEVPERACASEEVPTLTYEERVGFKKSR----DVFGLDFGTTSAKQPTQPASELPSGRL 389

Query: 321 WHTACASDEGEVIVFGGCANN 341
           +H A    +  + +FGG  +N
Sbjct: 390 FHAAAVISDA-MYIFGGTVDN 409



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 68/275 (24%), Positives = 109/275 (39%), Gaps = 43/275 (15%)

Query: 110 HSRGNTNKFYMLDSRSTDRVLQWERID-CQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPE 168
           HS  ++ ++  L+    + V +W R+  C     + + K  V  YK+ +  FGG      
Sbjct: 32  HSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGG------ 85

Query: 169 DKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGN 228
                            +     ND +   D +  +W +  TTG  P+PR  H+    G+
Sbjct: 86  ----------------DNGKTMLNDLLRF-DVKDCSWCRAFTTGTPPAPRYHHSAVVYGS 128

Query: 229 RGFVFGGRYRD-------ARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHL 281
             FVFGG   D          NDL      T +W E   +G  PV RS H  T V SD L
Sbjct: 129 SMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGAT-VYSDKL 187

Query: 282 FLFGGFTTDKQPLSDAWTYCISKNE---WIQFNHPYTEKPRLWHTACASDEGEVIVFGGC 338
           ++F G+  + + L+D WT  +   E   W +        P   +   A    ++ VF G 
Sbjct: 188 WIFAGYDGNAR-LNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQ 246

Query: 339 ANNLLVHHRAAHSNEILIFSVQPKSLVRLSLEAVI 373
           +        A  +N +  F  + K+  R+  E ++
Sbjct: 247 SG-------AKITNNLFQFEFKDKTWTRIPTEHLL 274



 Score = 62.4 bits (150), Expect = 7e-10
 Identities = 70/300 (23%), Positives = 115/300 (38%), Gaps = 37/300 (12%)

Query: 77  RWKKINTEGD-VPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERI 135
           RW+++    + V    S    V     +Y+FGG + +   N     D +       W R 
Sbjct: 53  RWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCS----WCRA 108

Query: 136 DCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHV 195
              G PP+ +      VY + +  FGGY                   +++S+ +  ND +
Sbjct: 109 FTTGTPPAPRYHHSAVVYGSSMFVFGGY---------------TGDIYSNSNLKNKND-L 152

Query: 196 HILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWE- 254
                 T  W++    G+ P  R+AH      ++ ++F G   +AR+ND+  + L   E 
Sbjct: 153 FEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDREL 212

Query: 255 --WNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDK--------QPLSDAWTYCISK 304
             W E+   G  P     +    V  D +F+F G +  K        +     WT     
Sbjct: 213 TCWEEVAQSGEIPPS-CCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRI--P 269

Query: 305 NEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFS-VQPKS 363
            E +    P   + R  HT  A D   + VFGG A+N L +    +  +   +  VQP S
Sbjct: 270 TEHLLRGSPPPPQRRYGHTMVAFDR-HLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSS 328


>gi|145701025 multiple EGF-like-domains 8 [Homo sapiens]
          Length = 2778

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 78/313 (24%), Positives = 127/313 (40%), Gaps = 67/313 (21%)

Query: 20  SYESMELA-CPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYN-METGR 77
           ++ES +L+  PA R  HVAV+    + + GG        L D  L  + +W ++ +  G 
Sbjct: 266 TWESWDLSPAPAARHSHVAVAWAGSLVLMGGE-------LADGSLTND-VWAFSPLGRGH 317

Query: 78  WKKIN---TEGDVPPSMSGSCAVCVDRV-LYLFGGH--HSRGNTNKF-YMLDSRSTDRVL 130
           W+ +    +    PP ++G  A  VD V LY+ GG   H   ++  F + LDS S     
Sbjct: 318 WELLAPPASSSSGPPGLAGHAAALVDDVWLYVSGGRTPHDLFSSGLFRFRLDSTSGG--- 374

Query: 131 QWER-IDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPR 189
            WE+ I   G PP++     V+   ++ +   G G+ P      T  F            
Sbjct: 375 YWEQVIPAGGRPPAATGHSMVFHAPSRALLVHG-GHRPS-----TARFS----------- 417

Query: 190 GWNDHVHILDTETFTWSQPITTG-------KAPSPRAAHACATVGNRGFVFGG----RYR 238
                V +  TE F   + + T        + P  RA H  + +GN   V+GG     Y+
Sbjct: 418 -----VRVNSTELFHVDRHVWTTLKGRDGLQGPRERAFHTASVLGNYMVVYGGNVHTHYQ 472

Query: 239 DARM--NDLHYLNLDTWEW---NELIPQG------ICPVGRSWHSLTPVSSDHLFLFGGF 287
           + +   + + + +L   +W    EL P G        P GR  H    +    L + GG+
Sbjct: 473 EEKCYEDGIFFYHLGCHQWVSGAELAPPGTPEGRAAPPSGRYSHVAAVLGGSVLLVAGGY 532

Query: 288 TTDKQPLSDAWTY 300
           +   +P  D   Y
Sbjct: 533 S--GRPRGDLMAY 543



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 10/160 (6%)

Query: 188  PRGWNDHVHILDTETFTWSQPITT----GKAPSPRAAHACATV-GNRG--FVFGGRYRDA 240
            P+G   +++        W+Q +      G  PSPR+ HA A V   RG  ++ GG     
Sbjct: 1465 PQGLLGNLYRYSVSERRWTQMLAGAEDGGPGPSPRSFHAAAYVPAGRGAMYLLGGLTAGG 1524

Query: 241  RMNDLHYLNLDTWEW-NELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWT 299
               D   LNL T +W  E  PQ +     + H+LT      L L GG++ +         
Sbjct: 1525 VTRDFWVLNLTTLQWRQEKAPQTVELPAVAGHTLTARRGLSLLLVGGYSPENGFNQQLLE 1584

Query: 300  YCISKNEWIQFNHPYTEKPRLWHTACASDEG--EVIVFGG 337
            Y ++   W+      T    L+  +    E    + VFGG
Sbjct: 1585 YQLATGTWVSGAQSGTPPTGLYGHSAVYHEATDSLYVFGG 1624



 Score = 29.6 bits (65), Expect = 5.1
 Identities = 22/80 (27%), Positives = 32/80 (40%), Gaps = 5/80 (6%)

Query: 213  KAPSPRAAHACATVGNRGFVFGGRYRDARMND---LHYLNLDTWEWNELIPQGIC--PVG 267
            K P PR  HA A +G+   V GGR      +    L+ +N + W   +L        P+ 
Sbjct: 1713 KEPRPRLFHASALLGDTMVVLGGRSDPDEFSSDVLLYQVNCNAWLLPDLTRSASVGPPME 1772

Query: 268  RSWHSLTPVSSDHLFLFGGF 287
             S           L++ GGF
Sbjct: 1773 ESVAHAVAAVGSRLYISGGF 1792


>gi|55956888 kelch/ankyrin repeat containing cyclin A1 interacting
           protein isoform a [Homo sapiens]
          Length = 349

 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 70/283 (24%), Positives = 109/283 (38%), Gaps = 40/283 (14%)

Query: 32  RSGHVAVS-DGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKK-INTEGDVPP 89
           RS H A   DGR + V GG+  ++             +   + E G W+    T GD PP
Sbjct: 79  RSHHDAAPVDGRWLCVVGGWDGSRRLAT---------VTALDTERGVWEAWTGTPGDCPP 129

Query: 90  S--MSGSCAVCVDRVLYLFG---GHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSS 144
           +   S +C    DR L + G   G H++      Y L    + R   +++  C     S 
Sbjct: 130 AGLSSHTCTRISDRELQVAGREGGIHTQRRYGSIYTLRLDPSARTYCYKQEGCHTASRSG 189

Query: 145 KDKLGVWVYK----NKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDT 200
                +        ++L+ FGG   L E +V G +   +        P       H+++ 
Sbjct: 190 HCAALLQTPGPHPGHQLLLFGGCN-LAEPEVAGHWSHGKIKEEPPVAP-------HLMEQ 241

Query: 201 ETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGG----RYRDARMNDLHYLNLDT---- 252
                S    + K P     H+C+ VG    +FGG    R RD   NDL+  +  T    
Sbjct: 242 LARLVSSGQGSQKGPHGLRHHSCSVVGPFAVLFGGETLTRARDTICNDLYIYDTRTSPPL 301

Query: 253 WEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLS 295
           W       +G+  +G      T + +D L+L GGF  D +  S
Sbjct: 302 WFHFPCADRGMKRMGHR----TCLWNDQLYLVGGFGEDGRTAS 340


>gi|8922640 kelch domain containing 8A [Homo sapiens]
          Length = 350

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 37/154 (24%), Positives = 63/154 (40%), Gaps = 12/154 (7%)

Query: 192 NDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLD 251
           ++H+   D     W   ++    P+PR A      G++ +V GGR     +N     +++
Sbjct: 142 HNHLQHYDMLKDMW---VSLAPMPTPRYAATSFLRGSKIYVLGGRQSKYAVNAFEVFDIE 198

Query: 252 TWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTD---KQP--LSDAWTYCISKNE 306
           T  W +  P    P  R++ S   +  +HL+  GG       +QP  L     + + +  
Sbjct: 199 TRSWTK-FPN--IPYKRAFSSFVTL-DNHLYSLGGLRQGRLYRQPKFLRTMDVFDMEQGG 254

Query: 307 WIQFNHPYTEKPRLWHTACASDEGEVIVFGGCAN 340
           W++    +  K R       S  G VIV GG  N
Sbjct: 255 WLKMERSFFLKKRRADFVAGSLSGRVIVAGGLGN 288



 Score = 33.5 bits (75), Expect = 0.35
 Identities = 17/52 (32%), Positives = 28/52 (53%), Gaps = 8/52 (15%)

Query: 29  PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKK 80
           P  R+G    + G+ + V GG  +NQ        LP + + +YN++ G+WKK
Sbjct: 66  PTARAGVAVTALGKRIMVIGGVGTNQ--------LPLKVVEMYNIDEGKWKK 109


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score = 39.7 bits (91), Expect = 0.005
 Identities = 54/252 (21%), Positives = 91/252 (36%), Gaps = 48/252 (19%)

Query: 57  GLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTN 116
           G YD  L    +  YN ET  W ++   G +    S    V +D  +Y+ GG+    + +
Sbjct: 342 GGYDGQLRLSTVEAYNPETDTWTRV---GSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLS 398

Query: 117 KFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFE 176
                 S  TD+   W  +       S++   GV V++ ++   GG+         G   
Sbjct: 399 SVETY-SPETDK---WTVVTSMS---SNRSAAGVTVFEGRIYVSGGHD--------GLQI 443

Query: 177 FDETSFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGR 236
           F     +N  H   W+    +L                 + R  H  A++G++ FV GG 
Sbjct: 444 FSSVEHYN-HHTATWHPAAGML-----------------NKRCRHGAASLGSKMFVCGGY 485

Query: 237 YRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDK----- 291
                ++     +    +W  ++P       RS  SL   S   L+  GG+         
Sbjct: 486 DGSGFLSIAEMYSSVADQWCLIVPM---HTRRSRVSLV-ASCGRLYAVGGYDGQSNLSSV 541

Query: 292 ---QPLSDAWTY 300
               P +D WT+
Sbjct: 542 EMYDPETDCWTF 553



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 27/94 (28%), Positives = 37/94 (39%), Gaps = 16/94 (17%)

Query: 31  ERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELW--IYNMETGRWKKINTEGDVP 88
           +R  H A S G  MFV GGY  +    + + Y    + W  I  M T R +         
Sbjct: 466 KRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSR--------- 516

Query: 89  PSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLD 122
            S+  SC       LY  GG+  + N +   M D
Sbjct: 517 VSLVASCG-----RLYAVGGYDGQSNLSSVEMYD 545


>gi|45643138 kelch-like 13 [Homo sapiens]
          Length = 655

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 32/133 (24%), Positives = 56/133 (42%), Gaps = 16/133 (12%)

Query: 34  GHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSG 93
           GH     G  M++ GG   +  +         +EL  ++ +T +W +   +  +      
Sbjct: 480 GHAGTVYGGVMYISGGITHDTFQ---------KELMCFDPDTDKWIQ---KAPMTTVRGL 527

Query: 94  SCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVL-QWERIDCQGIPPSSKDKLGVWV 152
            C   V   LY+ GG+H RG ++   +L       +L QW  I         +  +GV V
Sbjct: 528 HCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAM---LRGQSDVGVAV 584

Query: 153 YKNKLIFFGGYGY 165
           ++NK+   GGY +
Sbjct: 585 FENKIYVVGGYSW 597



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 70/343 (20%), Positives = 117/343 (34%), Gaps = 98/343 (28%)

Query: 20  SYESMELACPAERSGHVAV-SDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRW 78
           +Y+ M    P  +S   A+ SD  H+   GG    Q+       +  +EL +Y+ +   W
Sbjct: 317 NYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQL-------VVSKELRMYDEKAHEW 369

Query: 79  KKINTEGDVPPSMSGSCAVCVDRVLYLFGG---HHSRGNT------------NKFYMLDS 123
           K +    D P    G   +     LY+ GG   + ++G T            NK+  + S
Sbjct: 370 KSL-APMDAPRYQHGIAVI--GNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 426

Query: 124 RSTDRVL--------------------QWERIDCQGIPPSSKDKLGVWVYKNKL------ 157
            +  R                      +   ++C         +   W Y  K+      
Sbjct: 427 LNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN------PRTNEWTYVAKMSEPHYG 480

Query: 158 ---IFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILDTETFTWSQ--PITTG 212
                +GG  Y+       TF+ +   F                D +T  W Q  P+TT 
Sbjct: 481 HAGTVYGGVMYISGGITHDTFQKELMCF----------------DPDTDKWIQKAPMTT- 523

Query: 213 KAPSPRAAHACATVGNRGFVFGGR-------YRDARMNDLHYLNLDTWEWNELIPQGICP 265
                R  H   TVG R +V GG        Y D    + +   LD W     + +G   
Sbjct: 524 ----VRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSD 579

Query: 266 VGRSWHSLTPVSSDHLFLFGGFTTDKQPLSD-AWTYCISKNEW 307
           VG        V  + +++ GG++ + + + +    Y   K+EW
Sbjct: 580 VG------VAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616


>gi|24308181 kelch-like 9 [Homo sapiens]
          Length = 617

 Score = 38.1 bits (87), Expect = 0.014
 Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 16/133 (12%)

Query: 34  GHVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSG 93
           GH     G  M++ GG   +  +          EL  ++ +T +W +   +  +      
Sbjct: 438 GHAGTVYGGLMYISGGITHDTFQN---------ELMCFDPDTDKWMQ---KAPMTTVRGL 485

Query: 94  SCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVL-QWERIDCQGIPPSSKDKLGVWV 152
            C   V   LY+ GG+H RG ++   +L        L QW  I         +  +GV V
Sbjct: 486 HCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAM---LRGQSDVGVAV 542

Query: 153 YKNKLIFFGGYGY 165
           ++NK+   GGY +
Sbjct: 543 FENKIYVVGGYSW 555



 Score = 33.5 bits (75), Expect = 0.35
 Identities = 62/293 (21%), Positives = 107/293 (36%), Gaps = 47/293 (16%)

Query: 20  SYESMELACPAERSGHVAV-SDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRW 78
           +Y+ M    P  +S   A+ SD  H+   GG    Q+       +  +EL +Y+     W
Sbjct: 275 NYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQL-------VVSKELRMYDERAQEW 327

Query: 79  KKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQ 138
           + +    D P    G   +     LY+ GG  +     K       + D V +++    +
Sbjct: 328 RSL-APMDAPRYQHGIAVI--GNFLYVVGGQSNYDTKGK------TAVDTVFRFDPRYNK 378

Query: 139 GIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHIL 198
            +  +S ++   + + + L    G+ Y     V G     E +     +PR  N+     
Sbjct: 379 WMQVASLNEKRTFFHLSAL---KGHLYA----VGGRSAAGELATVECYNPR-MNE----- 425

Query: 199 DTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNEL 258
                 WS      K   P   HA    G   ++ GG   D   N+L   + DT +W + 
Sbjct: 426 ------WSY---VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQK 476

Query: 259 IPQGICPVGRSWHSLTPVSSDHLFLFGG----FTTDKQPLSDAWTYCISKNEW 307
            P       R  H +  V  D L++ GG     T+D   +     Y  + ++W
Sbjct: 477 APM---TTVRGLHCMCTV-GDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQW 525


>gi|25188199 leucine carboxyl methyltransferase 2 [Homo sapiens]
          Length = 686

 Score = 36.2 bits (82), Expect = 0.055
 Identities = 32/112 (28%), Positives = 51/112 (45%), Gaps = 9/112 (8%)

Query: 231 FVFGGR-YRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTT 289
           FV+GGR   +  ++D H+L++ T  W  +  +G  P  R  HS        L + GG   
Sbjct: 496 FVYGGRSVVEPVLSDWHFLHVGTMAWVRIPVEGEVPEARHSHSACTWQGGAL-IAGGLGA 554

Query: 290 DKQPLSDAW----TYCISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGG 337
            ++PL+         C    E +    P T  PR  HTA   + G++++ GG
Sbjct: 555 SEEPLNSVLFLRPISCGFLWESVDIQPPIT--PRYSHTAHVLN-GKLLLVGG 603


>gi|40255071 kelch-like 23 [Homo sapiens]
          Length = 558

 Score = 35.8 bits (81), Expect = 0.071
 Identities = 22/72 (30%), Positives = 37/72 (51%), Gaps = 16/72 (22%)

Query: 41  GRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSG---SCAV 97
           G +++V GGY+++ +  L       + +WIYN E+  W    TEG   P ++     CAV
Sbjct: 319 GPNIYVTGGYRTDNIEAL-------DTVWIYNSESDEW----TEG--LPMLNARYYHCAV 365

Query: 98  CVDRVLYLFGGH 109
            +   +Y  GG+
Sbjct: 366 TLGGCVYALGGY 377



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 36/137 (26%), Positives = 56/137 (40%), Gaps = 22/137 (16%)

Query: 35  HVAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELW--IYNMETGRWKKINTEGDVPPSMS 92
           H AV+ G  ++  GGY+        +FY P +E W  I NM  G                
Sbjct: 362 HCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKG---------------V 406

Query: 93  GSCAVCV-DRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVW 151
           G+   CV   V+Y+ GGH     +  +  + S ++D + +W  I      P  +  L   
Sbjct: 407 GNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSD-INEWSLITSS---PHPEYGLCSV 462

Query: 152 VYKNKLIFFGGYGYLPE 168
            ++NKL   GG   + E
Sbjct: 463 PFENKLYLVGGQTTITE 479


>gi|158508542 kelch-like 33 [Homo sapiens]
          Length = 453

 Score = 34.7 bits (78), Expect = 0.16
 Identities = 26/93 (27%), Positives = 35/93 (37%), Gaps = 5/93 (5%)

Query: 217 PRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPV 276
           PRA H  A +G R +V GG      +       L T  W  L P     VG    + + V
Sbjct: 327 PRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVG----AASAV 382

Query: 277 SSDHLFLFGGFTTDKQPLSD-AWTYCISKNEWI 308
               L + GG++     LS     YC     W+
Sbjct: 383 LQGELLVLGGYSHRTYALSHLIHAYCPGLGRWL 415


>gi|31881798 muskelin 1, intracellular mediator containing kelch
           motifs isoform 2 [Homo sapiens]
          Length = 735

 Score = 34.3 bits (77), Expect = 0.21
 Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 9/61 (14%)

Query: 255 WNELIPQGICPVG-------RSWHSLT-PVSSDHLFLFGGFTTDKQPLSDAWTYCISKNE 306
           W+++IP+     G       R  H +   V ++ ++LFGG+    Q L+D W Y + +N+
Sbjct: 251 WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWD-GTQDLADFWAYSVKENQ 309

Query: 307 W 307
           W
Sbjct: 310 W 310


>gi|223890246 muskelin 1, intracellular mediator containing kelch
           motifs isoform 1 [Homo sapiens]
          Length = 712

 Score = 34.3 bits (77), Expect = 0.21
 Identities = 18/61 (29%), Positives = 32/61 (52%), Gaps = 9/61 (14%)

Query: 255 WNELIPQGICPVG-------RSWHSLT-PVSSDHLFLFGGFTTDKQPLSDAWTYCISKNE 306
           W+++IP+     G       R  H +   V ++ ++LFGG+    Q L+D W Y + +N+
Sbjct: 228 WSQIIPKSTKGDGEDNRPGMRGGHQMVIDVQTETVYLFGGWD-GTQDLADFWAYSVKENQ 286

Query: 307 W 307
           W
Sbjct: 287 W 287


>gi|55956892 kelch/ankyrin repeat containing cyclin A1 interacting
           protein isoform c [Homo sapiens]
          Length = 111

 Score = 34.3 bits (77), Expect = 0.21
 Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 12/91 (13%)

Query: 213 KAPSPRAAHACATVGNRGFVFGG----RYRDARMNDLHYLNLDT----WEWNELIPQGIC 264
           K P     H+C+ VG    +FGG    R RD   NDL+  +  T    W       +G+ 
Sbjct: 16  KGPHGLRHHSCSVVGPFAVLFGGETLTRARDTICNDLYIYDTRTSPPLWFHFPCADRGMK 75

Query: 265 PVGRSWHSLTPVSSDHLFLFGGFTTDKQPLS 295
            +G      T + +D L+L GGF  D +  S
Sbjct: 76  RMGHR----TCLWNDQLYLVGGFGEDGRTAS 102


>gi|156616301 kelch-like 32 [Homo sapiens]
          Length = 620

 Score = 34.3 bits (77), Expect = 0.21
 Identities = 36/151 (23%), Positives = 59/151 (39%), Gaps = 20/151 (13%)

Query: 214 APSP--RAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWE-----WNELIPQGICPV 266
           AP P  R+ H  A +G+  FV GG    A            ++     W E+ P   C  
Sbjct: 330 APMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNSWAEIAPMKNCRE 389

Query: 267 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKPRLWHTACA 326
               H +     ++L+  GG    +Q L     YC  KN+W  F   + ++    H    
Sbjct: 390 ----HFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKW-TFVQSF-DRSLSCHAGYV 443

Query: 327 SDEGEVIVFGGCANNLLVHHRAAHSNEILIF 357
           +D G + + GG  N       A + N ++++
Sbjct: 444 AD-GLLWISGGVTNT------AQYQNRLMVY 467


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score = 33.9 bits (76), Expect = 0.27
 Identities = 59/269 (21%), Positives = 88/269 (32%), Gaps = 67/269 (24%)

Query: 36  VAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMS--- 92
           VAV D + +FV GG    +     + Y P+ + W                 V P MS   
Sbjct: 501 VAVIDDK-LFVIGGRDGLKTLNTVECYNPKTKTWT----------------VLPPMSTHR 543

Query: 93  -GSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVW 151
            G     ++  +Y  GGH      N     D +S     QW  +    I  S+   +GV 
Sbjct: 544 HGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ----QWTFVASMSIARST---VGVA 596

Query: 152 VYKNKLIFFGGYGYLPEDKVLGTFEFDE--TSFWN------------------------- 184
               KL   GG         L + E+ +  T+ WN                         
Sbjct: 597 ALNGKLYSVGGRD---GSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVG 653

Query: 185 ------SSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYR 238
                 S+H     D+V   D +T TW+          PR A     +G+R +  GG   
Sbjct: 654 GHDAPASNHCSRLLDYVERYDPKTDTWTM---VAPLSMPRDAVGVCLLGDRLYAVGGYDG 710

Query: 239 DARMNDLHYLNLDTWEWNELIPQGICPVG 267
              +N +   +  T EW ++    I   G
Sbjct: 711 QTYLNTMESYDPQTNEWTQMASLNIGRAG 739


>gi|194097389 kelch-like 38 [Homo sapiens]
          Length = 581

 Score = 33.5 bits (75), Expect = 0.35
 Identities = 25/98 (25%), Positives = 40/98 (40%), Gaps = 15/98 (15%)

Query: 251 DTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQF 310
           + WE    +P G+       H    V    L+LFGG    + P+     Y IS+N W + 
Sbjct: 409 NVWESMASMPVGVL------HPAVAVKDQRLYLFGGEDIMQNPVRLIQVYHISRNSWFKM 462

Query: 311 NHPYTEKPRLWHTACASDE--GE-VIVFGGCANNLLVH 345
                 + R+    CA     GE +++ GG    +L +
Sbjct: 463 ------ETRMIKNVCAPAVVLGERIVIVGGYTRRILAY 494


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score = 33.1 bits (74), Expect = 0.46
 Identities = 58/267 (21%), Positives = 88/267 (32%), Gaps = 63/267 (23%)

Query: 36  VAVSDGRHMFVWGGYKSNQVRGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMS--- 92
           VAV D + ++V GG    +     + + P  ++W                 V P MS   
Sbjct: 471 VAVIDNK-LYVVGGRDGLKTLNTVECFNPVGKIWT----------------VMPPMSTHR 513

Query: 93  -GSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVLQWERIDCQGIPPSSKDKLGVW 151
            G     ++  +Y  GGH      N     D        QW  +     P S+   +GV 
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR----QWNYVASMSTPRST---VGVV 566

Query: 152 VYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWN--------------------------- 184
              NKL   GG       K +  F+   T+ W+                           
Sbjct: 567 ALNNKLYAIGGRDGSSCLKSMEYFD-PHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH 625

Query: 185 ----SSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDA 240
               S+H    +D V   D +  +WS   T      PR A A   +G++ +V GG     
Sbjct: 626 DAPASNHCSRLSDCVERYDPKGDSWS---TVAPLSVPRDAVAVCPLGDKLYVVGGYDGHT 682

Query: 241 RMNDLHYLNLDTWEWNELIPQGICPVG 267
            +N +   +    EW E +P  I   G
Sbjct: 683 YLNTVESYDAQRNEWKEEVPVNIGRAG 709


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score = 33.1 bits (74), Expect = 0.46
 Identities = 51/237 (21%), Positives = 79/237 (33%), Gaps = 40/237 (16%)

Query: 71  YNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTDRVL 130
           Y+ +T  W+ +     +     G     +D +LY  GGH      N     D ++     
Sbjct: 338 YDPQTNEWRMV---ASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTN---- 390

Query: 131 QWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRG 190
           QW       + P+S  +  V V        GG+ Y    +       D  S  N      
Sbjct: 391 QWS----SDVAPTSTCRTSVGV-----AVLGGFLYAVGGQ-------DGVSCLNI----- 429

Query: 191 WNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNL 250
               V   D +   W++        + R   A A +G   +  GG    + +N +   N 
Sbjct: 430 ----VERYDPKENKWTR---VASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNP 482

Query: 251 DTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 307
               W+ + P G     R  H    V  D ++  GG   D   LS A  Y    N+W
Sbjct: 483 QENRWHTIAPMGT----RRKHLGCAVYQDMIYAVGG-RDDTTELSSAERYNPRTNQW 534


>gi|24432026 kelch-like [Homo sapiens]
          Length = 634

 Score = 32.7 bits (73), Expect = 0.60
 Identities = 21/91 (23%), Positives = 42/91 (46%), Gaps = 7/91 (7%)

Query: 220 AHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSD 279
           AHA AT+  + ++  GR  +  + + H  +  +  W+ L      PV R+WH +  +  +
Sbjct: 438 AHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADG---PVRRAWHGMATL-LN 493

Query: 280 HLFLFGGFTTD---KQPLSDAWTYCISKNEW 307
            L++ GG   D   ++ +     Y  +  +W
Sbjct: 494 KLYVIGGSNNDAGYRRDVHQVACYSCTSGQW 524


>gi|55749726 kelch domain containing 5 [Homo sapiens]
          Length = 505

 Score = 32.0 bits (71), Expect = 1.0
 Identities = 13/34 (38%), Positives = 21/34 (61%)

Query: 276 VSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQ 309
           +  ++LF+ GG+    Q +S A +Y  S NEW+Q
Sbjct: 250 ILDNYLFIVGGYRITSQEISAAHSYNPSTNEWLQ 283


>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
          Length = 642

 Score = 32.0 bits (71), Expect = 1.0
 Identities = 16/45 (35%), Positives = 24/45 (53%)

Query: 212 GKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWN 256
           G   SPR+    ATVGN  +  GG   +  +N +   NL++ EW+
Sbjct: 590 GNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.456 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,114,042
Number of Sequences: 37866
Number of extensions: 855858
Number of successful extensions: 1703
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 14
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 1528
Number of HSP's gapped (non-prelim): 110
length of query: 406
length of database: 18,247,518
effective HSP length: 105
effective length of query: 301
effective length of database: 14,271,588
effective search space: 4295747988
effective search space used: 4295747988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.