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Search of human proteins with 76563940
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|76563940 synuclein alpha interacting protein [Homo sapiens]
(919 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|76563940 synuclein alpha interacting protein [Homo sapiens] 1819 0.0
gi|110431370 espin [Homo sapiens] 83 1e-15
gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens] 79 3e-14
gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens] 76 2e-13
gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens] 76 2e-13
gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens] 76 2e-13
gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens] 76 2e-13
gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens] 76 2e-13
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 69 3e-11
gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens] 68 3e-11
gi|116325987 ankyrin repeat domain 42 [Homo sapiens] 67 8e-11
gi|70995241 ankyrin repeat domain 10 [Homo sapiens] 66 1e-10
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 65 3e-10
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 65 4e-10
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 63 1e-09
gi|155969701 espin-like [Homo sapiens] 63 1e-09
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 63 1e-09
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 62 2e-09
gi|239754056 PREDICTED: ankyrin repeat and death domain containi... 61 5e-09
gi|239748583 PREDICTED: ankyrin repeat and death domain containi... 61 5e-09
gi|239742602 PREDICTED: ankyrin repeat and death domain containi... 61 5e-09
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 60 1e-08
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 59 2e-08
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 59 2e-08
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 59 2e-08
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 59 2e-08
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 59 2e-08
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 59 2e-08
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 59 2e-08
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 59 2e-08
>gi|76563940 synuclein alpha interacting protein [Homo sapiens]
Length = 919
Score = 1819 bits (4711), Expect = 0.0
Identities = 919/919 (100%), Positives = 919/919 (100%)
Query: 1 MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNT 60
MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNT
Sbjct: 1 MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNT 60
Query: 61 QKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQEL 120
QKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQEL
Sbjct: 61 QKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQEL 120
Query: 121 GPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGL 180
GPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGL
Sbjct: 121 GPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGL 180
Query: 181 CTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISP 240
CTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISP
Sbjct: 181 CTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISP 240
Query: 241 PLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSG 300
PLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSG
Sbjct: 241 PLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSG 300
Query: 301 LNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQ 360
LNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQ
Sbjct: 301 LNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQ 360
Query: 361 GHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDF 420
GHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDF
Sbjct: 361 GHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDF 420
Query: 421 PSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG 480
PSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG
Sbjct: 421 PSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG 480
Query: 481 ANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQ 540
ANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQ
Sbjct: 481 ANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQ 540
Query: 541 NQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGS 600
NQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGS
Sbjct: 541 NQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGS 600
Query: 601 LSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKR 660
LSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKR
Sbjct: 601 LSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKR 660
Query: 661 ELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLM 720
ELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLM
Sbjct: 661 ELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLM 720
Query: 721 IKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQ 780
IKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQ
Sbjct: 721 IKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQ 780
Query: 781 PSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDK 840
PSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDK
Sbjct: 781 PSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDK 840
Query: 841 GRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRK 900
GRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRK
Sbjct: 841 GRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRK 900
Query: 901 TDAKGNPASSASKGKNKAA 919
TDAKGNPASSASKGKNKAA
Sbjct: 901 TDAKGNPASSASKGKNKAA 919
>gi|110431370 espin [Homo sapiens]
Length = 854
Score = 82.8 bits (203), Expect = 1e-15
Identities = 71/250 (28%), Positives = 109/250 (43%), Gaps = 32/250 (12%)
Query: 348 ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
+NG L++A +GH E Q+L G D + R + +TP A + G + W+VS
Sbjct: 170 KNGATPLYLACQEGHLEVTQYLVQECGADP-HARAHDGMTPLHAAAQMGHSPVIVWLVSC 228
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
T+ ++ KD + +H+A G K+L WLL E D G + +H A+++
Sbjct: 229 TD-VSLSEQDKDGATAMHFAASRGHTKVLSWLLLHGGEIS-----ADLWGGTPLHDAAEN 282
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTK 527
G L C Q LV GA + +++ G + ++ GH+ C+RYL VE
Sbjct: 283 GELECCQILVVNGAELDVRDRDGYTAADLSDFNGHSHCTRYLRTVENL------------ 330
Query: 528 QLKEQTVERVTLQNQLQQFLEA-QKSEGKSLPSSPSSP-------SSPASRKSQWKSPDA 579
+VE L LEA Q G S P++ S SSP S S + S +
Sbjct: 331 -----SVEHRVLSRDPSAELEAKQPDSGMSSPNTTVSVQPLNFDLSSPTSTLSNYDSCSS 385
Query: 580 DDDSVAKSKP 589
S+ P
Sbjct: 386 SHSSIKGQHP 395
Score = 56.2 bits (134), Expect = 1e-07
Identities = 52/175 (29%), Positives = 84/175 (48%), Gaps = 9/175 (5%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
NG H A++ GH CLQ L S G + +++ T LA + G E V W++
Sbjct: 69 NGATPAHDASATGHLACLQWLLS-QGGCRVQDKDNSGATVLHLAARFGHPEVVNWLLH-- 125
Query: 409 EAIAELSCSKDFPSL-IHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + + D +L IHYA G L L++ E ++ ++G + +++A Q
Sbjct: 126 HGGGDPTAATDMGALPIHYAAAKGDFPSLRLLVEHYPE---GVNAQTKNGATPLYLACQE 182
Query: 468 GYLGCIQTLV-EYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQ 521
G+L Q LV E GA+ + H G P +A + GH+ +LV T +SL+ Q
Sbjct: 183 GHLEVTQYLVQECGADPHARAHDGMTPLHAAAQMGHSPVIVWLVSC-TDVSLSEQ 236
Score = 46.6 bits (109), Expect = 1e-04
Identities = 41/157 (26%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Query: 357 AASQGHAECLQ--HLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAEL 414
AA QG + L+ H L+G R+ P A + G+L C+R++V E A+
Sbjct: 9 AARQGELDVLRSLHAAGLLGPSL---RDPLDALPVHHAARAGKLHCLRFLVEEA-ALPAA 64
Query: 415 SCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQ 474
+ +++ + H A G L WLL + G + + D G + +H+A++ G+ +
Sbjct: 65 ARARNGATPAHDASATGHLACLQWLL---SQGGCRVQDKDNSGATVLHLAARFGHPEVVN 121
Query: 475 TLVEY-GANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
L+ + G + T G P A +G R LV
Sbjct: 122 WLLHHGGGDPTAATDMGALPIHYAAAKGDFPSLRLLV 158
Score = 33.1 bits (74), Expect = 1.2
Identities = 21/59 (35%), Positives = 31/59 (52%), Gaps = 3/59 (5%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
D++G +H AAS+GH + L L GE + TP A +NG+LEC + +V
Sbjct: 237 DKDGATAMHFAASRGHTKVLSWLLLHGGEISADLWGG---TPLHDAAENGELECCQILV 292
>gi|224809474 retinoic acid induced 14 isoform b [Homo sapiens]
Length = 951
Score = 78.6 bits (192), Expect = 3e-14
Identities = 123/544 (22%), Positives = 217/544 (39%), Gaps = 32/544 (5%)
Query: 346 HDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
HD G H+AA++GH ECL+ + + G D + ++T + LA KN EC+R ++
Sbjct: 49 HDSEGKTAFHLAAAKGHVECLRVMIT-HGVD-VTAQDTTGHSALHLAAKNSHHECIRKLL 106
Query: 406 SETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+++ AE S + +HYA G L +Q + E ++ D DGN + +A
Sbjct: 107 -QSKCPAE-SVDSSGKTALHYAAAQG----CLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKL 525
Q+G+ L+++GA+V +N +G A G + L+ ++L +
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSL--- 217
Query: 526 TKQLKEQTVERVTLQNQLQQFLEAQKSEGKSL--PSSPSSPSSPASRKSQWKSPDADDDS 583
+++ +Q L ++ S+ L P+ P S +S +S +P + +S
Sbjct: 218 --GYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQLSDVSSPRSITSTPLSGKES 275
Query: 584 VAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQ 643
V ++P + I SS K + DS LL +IS Q+ LSL
Sbjct: 276 VFFAEPPFKAEI--------SSIRENKDRLSDSTTGADSLL--DISSEADQQDLLSLLQA 325
Query: 644 DAQASSRNSKKI--PLEKRELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRP 701
+ + ++K++ L+ + K A L S + TD S + P
Sbjct: 326 KVASLTLHNKELQDKLQAKSPKEAE-ADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSP 384
Query: 702 QPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLES 761
++ S+ + + + + L +R S K L S +E L +
Sbjct: 385 SVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAEL--VCLNN 442
Query: 762 QYPGSGSIPPNQPSGDPQQPSPDS-TAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEE 820
S +Q + Q ++ V K L SP S S +LRVT EE
Sbjct: 443 TEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEE 502
Query: 821 -PVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNN 879
V++ + + E++K+K R L+ E G +K P + + + N N
Sbjct: 503 INVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMN 562
Query: 880 NYQA 883
+A
Sbjct: 563 KEKA 566
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/66 (28%), Positives = 37/66 (56%)
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++G S + D +G +A H+A+ G++ C++ ++ +G +VT Q+ G A + H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 505 CSRYLV 510
C R L+
Sbjct: 101 CIRKLL 106
Score = 35.8 bits (81), Expect = 0.19
Identities = 37/158 (23%), Positives = 71/158 (44%), Gaps = 30/158 (18%)
Query: 214 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFL-------NKTFSDP 266
KSP +A H + +T++ P L K G P+++S + + T +D
Sbjct: 344 KSPKEAEADLSFDSYH---STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 400
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEE--------QVSGLNRT---------SSQGP 309
+++++ D Q R L+SS AE K + ++ LN T S +
Sbjct: 401 RIQQLQEILQDLQKR---LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK 457
Query: 310 EERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHD 347
E +S+Y + +K +L++ K+ ++ L+ + DN H+
Sbjct: 458 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE 495
>gi|224809478 retinoic acid induced 14 isoform d [Homo sapiens]
Length = 983
Score = 75.9 bits (185), Expect = 2e-13
Identities = 127/568 (22%), Positives = 222/568 (39%), Gaps = 51/568 (8%)
Query: 346 HDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
HD G H+AA++GH ECL+ + + G D + ++T + LA KN EC+R ++
Sbjct: 52 HDSEGKTAFHLAAAKGHVECLRVMIT-HGVD-VTAQDTTGHSALHLAAKNSHHECIRKLL 109
Query: 406 SETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+++ AE S + +HYA G L +Q + E ++ D DGN + +A
Sbjct: 110 -QSKCPAE-SVDSSGKTALHYAAAQG----CLQAVQILCEHKSPINLKDLDGNIPLLLAV 163
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLAS----- 520
Q+G+ L+++GA+V +N +G A G + L+ ++L
Sbjct: 164 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYN 223
Query: 521 -------------QVVKLTKQLKEQTVERVTLQNQLQQFLE--------AQKSEGKSLPS 559
Q + L+K ++ ++ T Q Q + +K + P
Sbjct: 224 ALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPI 283
Query: 560 SPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKI 619
SP+ S +S +S +P + +SV ++P + I SS K + DS
Sbjct: 284 SPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEI--------SSIRENKDRLSDSTTG 335
Query: 620 LRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKI--PLEKRELKLARLRQLMQRSLSE 677
LL +IS Q+ LSL + + ++K++ L+ + K A L S
Sbjct: 336 ADSLL--DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAE-ADLSFDSYHS 392
Query: 678 SDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSI 737
+ TD S + P ++ S+ + + + + L +R S
Sbjct: 393 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 452
Query: 738 KASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDS-TAAQKVATSPK 796
K L S +E L + S +Q + Q ++ V K
Sbjct: 453 AERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK 510
Query: 797 SALKSPSSKRRTSQNLKLRVTFEE-PVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGD 855
L SP S S +LRVT EE V++ + + E++K+K R L+ E G
Sbjct: 511 LGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT 570
Query: 856 QLKRPFGAFRSIMETLSGNQNNNNNYQA 883
+K P + + + N N +A
Sbjct: 571 VIKPPVEEYEEMKSSYCSVIENMNKEKA 598
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/66 (28%), Positives = 37/66 (56%)
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++G S + D +G +A H+A+ G++ C++ ++ +G +VT Q+ G A + H
Sbjct: 44 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 103
Query: 505 CSRYLV 510
C R L+
Sbjct: 104 CIRKLL 109
Score = 35.8 bits (81), Expect = 0.19
Identities = 37/158 (23%), Positives = 71/158 (44%), Gaps = 30/158 (18%)
Query: 214 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFL-------NKTFSDP 266
KSP +A H + +T++ P L K G P+++S + + T +D
Sbjct: 376 KSPKEAEADLSFDSYH---STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 432
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEE--------QVSGLNRT---------SSQGP 309
+++++ D Q R L+SS AE K + ++ LN T S +
Sbjct: 433 RIQQLQEILQDLQKR---LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK 489
Query: 310 EERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHD 347
E +S+Y + +K +L++ K+ ++ L+ + DN H+
Sbjct: 490 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE 527
Score = 35.0 bits (79), Expect = 0.32
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
A++NG E V ++ + A A S+ + H A G + L + M G+ +
Sbjct: 29 AVENGDAEKVASLLGKKGASATKHDSEG-KTAFHLAAAKGHVECL----RVMITHGVDVT 83
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 501
D G+SA+H+A+++ + CI+ L++ + +G+ A QG
Sbjct: 84 AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 133
>gi|224809476 retinoic acid induced 14 isoform c [Homo sapiens]
Length = 972
Score = 75.9 bits (185), Expect = 2e-13
Identities = 127/568 (22%), Positives = 222/568 (39%), Gaps = 51/568 (8%)
Query: 346 HDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
HD G H+AA++GH ECL+ + + G D + ++T + LA KN EC+R ++
Sbjct: 41 HDSEGKTAFHLAAAKGHVECLRVMIT-HGVD-VTAQDTTGHSALHLAAKNSHHECIRKLL 98
Query: 406 SETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+++ AE S + +HYA G L +Q + E ++ D DGN + +A
Sbjct: 99 -QSKCPAE-SVDSSGKTALHYAAAQG----CLQAVQILCEHKSPINLKDLDGNIPLLLAV 152
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLAS----- 520
Q+G+ L+++GA+V +N +G A G + L+ ++L
Sbjct: 153 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYN 212
Query: 521 -------------QVVKLTKQLKEQTVERVTLQNQLQQFLE--------AQKSEGKSLPS 559
Q + L+K ++ ++ T Q Q + +K + P
Sbjct: 213 ALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPI 272
Query: 560 SPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKI 619
SP+ S +S +S +P + +SV ++P + I SS K + DS
Sbjct: 273 SPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEI--------SSIRENKDRLSDSTTG 324
Query: 620 LRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKI--PLEKRELKLARLRQLMQRSLSE 677
LL +IS Q+ LSL + + ++K++ L+ + K A L S
Sbjct: 325 ADSLL--DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAE-ADLSFDSYHS 381
Query: 678 SDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSI 737
+ TD S + P ++ S+ + + + + L +R S
Sbjct: 382 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 441
Query: 738 KASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDS-TAAQKVATSPK 796
K L S +E L + S +Q + Q ++ V K
Sbjct: 442 AERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK 499
Query: 797 SALKSPSSKRRTSQNLKLRVTFEE-PVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGD 855
L SP S S +LRVT EE V++ + + E++K+K R L+ E G
Sbjct: 500 LGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT 559
Query: 856 QLKRPFGAFRSIMETLSGNQNNNNNYQA 883
+K P + + + N N +A
Sbjct: 560 VIKPPVEEYEEMKSSYCSVIENMNKEKA 587
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/66 (28%), Positives = 37/66 (56%)
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++G S + D +G +A H+A+ G++ C++ ++ +G +VT Q+ G A + H
Sbjct: 33 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 92
Query: 505 CSRYLV 510
C R L+
Sbjct: 93 CIRKLL 98
Score = 35.8 bits (81), Expect = 0.19
Identities = 37/158 (23%), Positives = 71/158 (44%), Gaps = 30/158 (18%)
Query: 214 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFL-------NKTFSDP 266
KSP +A H + +T++ P L K G P+++S + + T +D
Sbjct: 365 KSPKEAEADLSFDSYH---STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 421
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEE--------QVSGLNRT---------SSQGP 309
+++++ D Q R L+SS AE K + ++ LN T S +
Sbjct: 422 RIQQLQEILQDLQKR---LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK 478
Query: 310 EERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHD 347
E +S+Y + +K +L++ K+ ++ L+ + DN H+
Sbjct: 479 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE 516
Score = 35.0 bits (79), Expect = 0.32
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
A++NG E V ++ + A A S+ + H A G + L + M G+ +
Sbjct: 18 AVENGDAEKVASLLGKKGASATKHDSEG-KTAFHLAAAKGHVECL----RVMITHGVDVT 72
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 501
D G+SA+H+A+++ + CI+ L++ + +G+ A QG
Sbjct: 73 AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 122
>gi|224809472 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 75.9 bits (185), Expect = 2e-13
Identities = 127/568 (22%), Positives = 222/568 (39%), Gaps = 51/568 (8%)
Query: 346 HDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
HD G H+AA++GH ECL+ + + G D + ++T + LA KN EC+R ++
Sbjct: 49 HDSEGKTAFHLAAAKGHVECLRVMIT-HGVD-VTAQDTTGHSALHLAAKNSHHECIRKLL 106
Query: 406 SETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+++ AE S + +HYA G L +Q + E ++ D DGN + +A
Sbjct: 107 -QSKCPAE-SVDSSGKTALHYAAAQG----CLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLAS----- 520
Q+G+ L+++GA+V +N +G A G + L+ ++L
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYN 220
Query: 521 -------------QVVKLTKQLKEQTVERVTLQNQLQQFLE--------AQKSEGKSLPS 559
Q + L+K ++ ++ T Q Q + +K + P
Sbjct: 221 ALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPI 280
Query: 560 SPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKI 619
SP+ S +S +S +P + +SV ++P + I SS K + DS
Sbjct: 281 SPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEI--------SSIRENKDRLSDSTTG 332
Query: 620 LRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKI--PLEKRELKLARLRQLMQRSLSE 677
LL +IS Q+ LSL + + ++K++ L+ + K A L S
Sbjct: 333 ADSLL--DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAE-ADLSFDSYHS 389
Query: 678 SDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSI 737
+ TD S + P ++ S+ + + + + L +R S
Sbjct: 390 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 449
Query: 738 KASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDS-TAAQKVATSPK 796
K L S +E L + S +Q + Q ++ V K
Sbjct: 450 AERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK 507
Query: 797 SALKSPSSKRRTSQNLKLRVTFEE-PVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGD 855
L SP S S +LRVT EE V++ + + E++K+K R L+ E G
Sbjct: 508 LGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT 567
Query: 856 QLKRPFGAFRSIMETLSGNQNNNNNYQA 883
+K P + + + N N +A
Sbjct: 568 VIKPPVEEYEEMKSSYCSVIENMNKEKA 595
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/66 (28%), Positives = 37/66 (56%)
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++G S + D +G +A H+A+ G++ C++ ++ +G +VT Q+ G A + H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 505 CSRYLV 510
C R L+
Sbjct: 101 CIRKLL 106
Score = 35.8 bits (81), Expect = 0.19
Identities = 37/158 (23%), Positives = 71/158 (44%), Gaps = 30/158 (18%)
Query: 214 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFL-------NKTFSDP 266
KSP +A H + +T++ P L K G P+++S + + T +D
Sbjct: 373 KSPKEAEADLSFDSYH---STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEE--------QVSGLNRT---------SSQGP 309
+++++ D Q R L+SS AE K + ++ LN T S +
Sbjct: 430 RIQQLQEILQDLQKR---LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK 486
Query: 310 EERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHD 347
E +S+Y + +K +L++ K+ ++ L+ + DN H+
Sbjct: 487 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE 524
Score = 35.0 bits (79), Expect = 0.32
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
A++NG E V ++ + A A S+ + H A G + L + M G+ +
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEG-KTAFHLAAAKGHVECL----RVMITHGVDVT 80
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 501
D G+SA+H+A+++ + CI+ L++ + +G+ A QG
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
>gi|224809470 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 75.9 bits (185), Expect = 2e-13
Identities = 127/568 (22%), Positives = 222/568 (39%), Gaps = 51/568 (8%)
Query: 346 HDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
HD G H+AA++GH ECL+ + + G D + ++T + LA KN EC+R ++
Sbjct: 49 HDSEGKTAFHLAAAKGHVECLRVMIT-HGVD-VTAQDTTGHSALHLAAKNSHHECIRKLL 106
Query: 406 SETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+++ AE S + +HYA G L +Q + E ++ D DGN + +A
Sbjct: 107 -QSKCPAE-SVDSSGKTALHYAAAQG----CLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLAS----- 520
Q+G+ L+++GA+V +N +G A G + L+ ++L
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYN 220
Query: 521 -------------QVVKLTKQLKEQTVERVTLQNQLQQFLE--------AQKSEGKSLPS 559
Q + L+K ++ ++ T Q Q + +K + P
Sbjct: 221 ALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPI 280
Query: 560 SPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKI 619
SP+ S +S +S +P + +SV ++P + I SS K + DS
Sbjct: 281 SPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEI--------SSIRENKDRLSDSTTG 332
Query: 620 LRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKI--PLEKRELKLARLRQLMQRSLSE 677
LL +IS Q+ LSL + + ++K++ L+ + K A L S
Sbjct: 333 ADSLL--DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAE-ADLSFDSYHS 389
Query: 678 SDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSI 737
+ TD S + P ++ S+ + + + + L +R S
Sbjct: 390 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 449
Query: 738 KASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDS-TAAQKVATSPK 796
K L S +E L + S +Q + Q ++ V K
Sbjct: 450 AERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK 507
Query: 797 SALKSPSSKRRTSQNLKLRVTFEE-PVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGD 855
L SP S S +LRVT EE V++ + + E++K+K R L+ E G
Sbjct: 508 LGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT 567
Query: 856 QLKRPFGAFRSIMETLSGNQNNNNNYQA 883
+K P + + + N N +A
Sbjct: 568 VIKPPVEEYEEMKSSYCSVIENMNKEKA 595
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/66 (28%), Positives = 37/66 (56%)
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++G S + D +G +A H+A+ G++ C++ ++ +G +VT Q+ G A + H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 505 CSRYLV 510
C R L+
Sbjct: 101 CIRKLL 106
Score = 35.8 bits (81), Expect = 0.19
Identities = 37/158 (23%), Positives = 71/158 (44%), Gaps = 30/158 (18%)
Query: 214 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFL-------NKTFSDP 266
KSP +A H + +T++ P L K G P+++S + + T +D
Sbjct: 373 KSPKEAEADLSFDSYH---STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEE--------QVSGLNRT---------SSQGP 309
+++++ D Q R L+SS AE K + ++ LN T S +
Sbjct: 430 RIQQLQEILQDLQKR---LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK 486
Query: 310 EERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHD 347
E +S+Y + +K +L++ K+ ++ L+ + DN H+
Sbjct: 487 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE 524
Score = 35.0 bits (79), Expect = 0.32
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
A++NG E V ++ + A A S+ + H A G + L + M G+ +
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEG-KTAFHLAAAKGHVECL----RVMITHGVDVT 80
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 501
D G+SA+H+A+++ + CI+ L++ + +G+ A QG
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
>gi|224809468 retinoic acid induced 14 isoform a [Homo sapiens]
Length = 980
Score = 75.9 bits (185), Expect = 2e-13
Identities = 127/568 (22%), Positives = 222/568 (39%), Gaps = 51/568 (8%)
Query: 346 HDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
HD G H+AA++GH ECL+ + + G D + ++T + LA KN EC+R ++
Sbjct: 49 HDSEGKTAFHLAAAKGHVECLRVMIT-HGVD-VTAQDTTGHSALHLAAKNSHHECIRKLL 106
Query: 406 SETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+++ AE S + +HYA G L +Q + E ++ D DGN + +A
Sbjct: 107 -QSKCPAE-SVDSSGKTALHYAAAQG----CLQAVQILCEHKSPINLKDLDGNIPLLLAV 160
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLAS----- 520
Q+G+ L+++GA+V +N +G A G + L+ ++L
Sbjct: 161 QNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYN 220
Query: 521 -------------QVVKLTKQLKEQTVERVTLQNQLQQFLE--------AQKSEGKSLPS 559
Q + L+K ++ ++ T Q Q + +K + P
Sbjct: 221 ALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPI 280
Query: 560 SPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKI 619
SP+ S +S +S +P + +SV ++P + I SS K + DS
Sbjct: 281 SPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEI--------SSIRENKDRLSDSTTG 332
Query: 620 LRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKI--PLEKRELKLARLRQLMQRSLSE 677
LL +IS Q+ LSL + + ++K++ L+ + K A L S
Sbjct: 333 ADSLL--DISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAE-ADLSFDSYHS 389
Query: 678 SDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSI 737
+ TD S + P ++ S+ + + + + L +R S
Sbjct: 390 TQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSE 449
Query: 738 KASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDS-TAAQKVATSPK 796
K L S +E L + S +Q + Q ++ V K
Sbjct: 450 AERKQLQVELQSRRAEL--VCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMK 507
Query: 797 SALKSPSSKRRTSQNLKLRVTFEE-PVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGD 855
L SP S S +LRVT EE V++ + + E++K+K R L+ E G
Sbjct: 508 LGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGT 567
Query: 856 QLKRPFGAFRSIMETLSGNQNNNNNYQA 883
+K P + + + N N +A
Sbjct: 568 VIKPPVEEYEEMKSSYCSVIENMNKEKA 595
Score = 45.1 bits (105), Expect = 3e-04
Identities = 19/66 (28%), Positives = 37/66 (56%)
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++G S + D +G +A H+A+ G++ C++ ++ +G +VT Q+ G A + H
Sbjct: 41 KKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHE 100
Query: 505 CSRYLV 510
C R L+
Sbjct: 101 CIRKLL 106
Score = 35.8 bits (81), Expect = 0.19
Identities = 37/158 (23%), Positives = 71/158 (44%), Gaps = 30/158 (18%)
Query: 214 KSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFL-------NKTFSDP 266
KSP +A H + +T++ P L K G P+++S + + T +D
Sbjct: 373 KSPKEAEADLSFDSYH---STQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDV 429
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEE--------QVSGLNRT---------SSQGP 309
+++++ D Q R L+SS AE K + ++ LN T S +
Sbjct: 430 RIQQLQEILQDLQKR---LESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLK 486
Query: 310 EERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHD 347
E +S+Y + +K +L++ K+ ++ L+ + DN H+
Sbjct: 487 ETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHE 524
Score = 35.0 bits (79), Expect = 0.32
Identities = 27/110 (24%), Positives = 51/110 (46%), Gaps = 5/110 (4%)
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
A++NG E V ++ + A A S+ + H A G + L + M G+ +
Sbjct: 26 AVENGDAEKVASLLGKKGASATKHDSEG-KTAFHLAAAKGHVECL----RVMITHGVDVT 80
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 501
D G+SA+H+A+++ + CI+ L++ + +G+ A QG
Sbjct: 81 AQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQG 130
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 68.6 bits (166), Expect = 3e-11
Identities = 63/232 (27%), Positives = 109/232 (46%), Gaps = 35/232 (15%)
Query: 352 NLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAI 411
+LLHIAA+ G ECL L N ++ TP LA +NGQ +C+ ++ E
Sbjct: 67 SLLHIAANCGSVECLVLLLKKGANP--NYQDISGCTPLHLAARNGQKKCMSKLL---EYS 121
Query: 412 AELS-CSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYL 470
A+++ C+ + + IH+ G+ ++L L+Q + + +D D G +A+HVA Q+G+
Sbjct: 122 ADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVSD----VDVEDAMGQTALHVACQNGHK 177
Query: 471 GCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV------------------- 511
+Q L++ GA++ N +G P A G ++ L++
Sbjct: 178 TTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCV 237
Query: 512 ----VETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLE--AQKSEGKSL 557
ETC L +L + + + T +N L+Q LE +Q+SE + L
Sbjct: 238 QGGYGETCEVLIQYHPRLFQTIIQMTQNEDLRENMLRQVLEHLSQQSESQYL 289
>gi|34577122 nuclear factor kappa-B, subunit 1 [Homo sapiens]
Length = 969
Score = 68.2 bits (165), Expect = 3e-11
Identities = 93/390 (23%), Positives = 164/390 (42%), Gaps = 44/390 (11%)
Query: 341 NLDKIHDENGNNLLHIAASQGHAECLQHL----TSLMGEDCLNERNTEKLTPAGLAIKNG 396
+L + DENG+++LH+A H++ ++ L + L+ +D +N RN TP LA+
Sbjct: 535 HLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLISDDIINMRNDLYQTPLHLAVITK 594
Query: 397 QLECVRWMVSETEAIAELSCSKDFP-SLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQ 455
Q + V ++ A A+LS S++H A G +K+L LL+ ++ + LD +
Sbjct: 595 QEDVVEDLL---RAGADLSLLDRLGNSVLHLAAKEGHDKVLSILLKH-KKAALLLDHPNG 650
Query: 456 DGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETC 515
DG +A+H+A L C+ LV GA+V Q ++ G T + +L V
Sbjct: 651 DGLNAIHLAMMSNSLPCLLLLVAAGADVNAQE----------QKSGRT--ALHLAVEHDN 698
Query: 516 MSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRK---- 571
+SLA ++ + V+ T + A + + ++ + P
Sbjct: 699 ISLAGCLL----LEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGADPLVENFEPL 754
Query: 572 ----SQWKSPDADDDSVAKSKP-GVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLLGK 626
W++ D+ V + P + QV L+ +P + SD +L Q K
Sbjct: 755 YDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILN----GKPYEPEFTSDDLLAQGDMK 810
Query: 627 EISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNSE 686
+++E+V Q LE D K ++L L L + S + S T +N E
Sbjct: 811 QLAEDVKLQLYKLLEIPDP------DKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYE 864
Query: 687 DPKTTPVRKADRPRPQPIVESVESMDSAES 716
T + R E++E + +A S
Sbjct: 865 VSGGTVRELVEALRQMGYTEAIEVIQAASS 894
>gi|116325987 ankyrin repeat domain 42 [Homo sapiens]
Length = 389
Score = 67.0 bits (162), Expect = 8e-11
Identities = 62/213 (29%), Positives = 96/213 (45%), Gaps = 21/213 (9%)
Query: 354 LHIAASQGHAECLQHLTSLM-----GEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
+H A G + L + L G D + T T + +A GQ CV+ ++
Sbjct: 30 IHDAVRAGDVKQLSEIVCLHWLLWHGAD-ITHVTTRGWTASHIAAIRGQDACVQALIMNG 88
Query: 409 EAIAELSCSKDFPSL-IHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
A L+ D +H A +G + LQ M G+ D+ VH A+ H
Sbjct: 89 ---ANLTAQDDRGCTPLHLAATHGHS----FTLQIMLRSGVDPSVTDKREWRPVHYAAFH 141
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTK 527
G LGC+Q LV++G ++ ++ G P A +GH C ++LV + MS A+QV+K
Sbjct: 142 GRLGCLQLLVKWGCSIEDVDYNGNLPVHLAAMEGHLHCFKFLV---SRMSSATQVLKAFN 198
Query: 528 QLKEQTV---ERVTLQNQLQQFLEAQKSEGKSL 557
E + +R QN L QF++ + EGK L
Sbjct: 199 DNGENVLDLAQRFFKQNIL-QFIQGAEYEGKDL 230
Score = 66.2 bits (160), Expect = 1e-10
Identities = 49/169 (28%), Positives = 82/169 (48%), Gaps = 13/169 (7%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGE-----DCLNERNTEKLTPAGLAIKNGQLECV 401
D NGN +H+AA +GH C + L S M N+ L A K L+ +
Sbjct: 161 DYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQNILQFI 220
Query: 402 RWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQG-ISLDEVDQDGNSA 460
+ E + + + + FP H A G L +L+ + E G I+++E +G++
Sbjct: 221 QGAEYEGKDLEDQE-TLAFPG--HVAAFKGD----LGMLKKLVEDGVININERADNGSTP 273
Query: 461 VHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYL 509
+H A+ G++ C+Q L++ GA+ + N AGE+PS A+R H + L
Sbjct: 274 MHKAAGQGHIECLQWLIKMGADSNITNKAGERPSDVAKRFAHLAAVKLL 322
Score = 43.9 bits (102), Expect = 7e-04
Identities = 47/198 (23%), Positives = 84/198 (42%), Gaps = 36/198 (18%)
Query: 347 DENGNNLLHIAASQGHAECLQ--------------------HLTSLMGE-DCL------- 378
D+ G LH+AA+ GH+ LQ H + G CL
Sbjct: 95 DDRGCTPLHLAATHGHSFTLQIMLRSGVDPSVTDKREWRPVHYAAFHGRLGCLQLLVKWG 154
Query: 379 ---NERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAEL--SCSKDFPSLIHYAGCYGQE 433
+ + P LA G L C +++VS + ++ + + + +++ A + ++
Sbjct: 155 CSIEDVDYNGNLPVHLAAMEGHLHCFKFLVSRMSSATQVLKAFNDNGENVLDLAQRFFKQ 214
Query: 434 KILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGA-NVTMQNHAGEK 492
IL + +Q + +G L++ + HVA+ G LG ++ LVE G N+ + G
Sbjct: 215 NILQF-IQGAEYEGKDLEDQETLAFPG-HVAAFKGDLGMLKKLVEDGVININERADNGST 272
Query: 493 PSQSAERQGHTLCSRYLV 510
P A QGH C ++L+
Sbjct: 273 PMHKAAGQGHIECLQWLI 290
>gi|70995241 ankyrin repeat domain 10 [Homo sapiens]
Length = 420
Score = 66.2 bits (160), Expect = 1e-10
Identities = 39/129 (30%), Positives = 70/129 (54%), Gaps = 5/129 (3%)
Query: 387 TPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQ 446
TP A G+LEC+ +V A +S ++ + H A G + L+WL+Q
Sbjct: 60 TPVHWAAHFGKLECLVQLV-RAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQ----A 114
Query: 447 GISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCS 506
G ++++ D +G + +H A++ G L CI LV GA+V ++N +G + A+ QG C+
Sbjct: 115 GANINKPDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECA 174
Query: 507 RYLVVVETC 515
++L+ ++ C
Sbjct: 175 QFLLNLQNC 183
Score = 33.9 bits (76), Expect = 0.72
Identities = 19/52 (36%), Positives = 28/52 (53%), Gaps = 2/52 (3%)
Query: 355 HIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
HIAA GH +CL L +N+ + E TP A ++G LEC+ +V+
Sbjct: 97 HIAAFGGHPQCLVWLIQAGAN--INKPDCEGETPIHKAARSGSLECISALVA 146
Score = 30.4 bits (67), Expect = 7.9
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 3/69 (4%)
Query: 338 AADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQ 397
A N++K D G +H AA G EC+ L + ++ RN LT A +A G
Sbjct: 114 AGANINK-PDCEGETPIHKAARSGSLECISALVANGAH--VDLRNASGLTAADIAQTQGF 170
Query: 398 LECVRWMVS 406
EC +++++
Sbjct: 171 QECAQFLLN 179
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 65.1 bits (157), Expect = 3e-10
Identities = 52/180 (28%), Positives = 84/180 (46%), Gaps = 14/180 (7%)
Query: 333 LLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLA 392
++P L++ N + D G LH AA GH E + L + +N + + A
Sbjct: 101 IIPLLSSVN---VSDRGGRTALHHAALNGHVEMVNLLLAKGAN--INAFDKKDRRALHWA 155
Query: 393 IKNGQLECVRWMVSETEAIAELSCS-KDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
G L+ V +++ AE++C K + +H A GQ ++ LL G+ +D
Sbjct: 156 AYMGHLDVVALLINHG---AEVTCKDKKGYTPLHAAASNGQINVVKHLLNL----GVEID 208
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH-TLCSRYLV 510
E++ GN+A+H+A +G + L++YGANV N+ G P A H LC LV
Sbjct: 209 EINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLV 268
Score = 62.4 bits (150), Expect = 2e-09
Identities = 46/161 (28%), Positives = 74/161 (45%), Gaps = 10/161 (6%)
Query: 345 IHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
I DE G L +AA +GH EC++ L + G + N K TP ++ NG C+R +
Sbjct: 570 IRDEKGRTALDLAAFKGHTECVEALIN-PGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Query: 405 VS---ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAV 461
+ EA+ P ++ A YG + LL E+ ++D VD G +A+
Sbjct: 629 LEIADNPEAVDVKDAKGQTPLMLAVA--YGHIDAVSLLL----EKEANVDTVDILGCTAL 682
Query: 462 HVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
H G+ C+Q L+E ++ ++ G P A +GH
Sbjct: 683 HRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGH 723
Score = 55.1 bits (131), Expect = 3e-07
Identities = 44/158 (27%), Positives = 70/158 (44%), Gaps = 7/158 (4%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D+ G LH AAS G ++HL +L E ++E N T +A NGQ V ++
Sbjct: 178 DKKGYTPLHAAASNGQINVVKHLLNLGVE--IDEINVYGNTALHIACYNGQDAVVNELID 235
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
+ + + + P +H+A + L LL G ++ +DG S +H+ +
Sbjct: 236 YGANVNQPNNNGFTP--LHFAAASTHGALCLELLV---NNGADVNIQSKDGKSPLHMTAV 290
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
HG QTL++ G + + G P A R GH L
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHEL 328
Score = 53.5 bits (127), Expect = 9e-07
Identities = 57/188 (30%), Positives = 85/188 (45%), Gaps = 18/188 (9%)
Query: 329 GQISLLPHLAADNLDKIHDE---NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEK 385
GQI+++ HL NL DE GN LHIA G + L +N+ N
Sbjct: 192 GQINVVKHLL--NLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGAN--VNQPNNNG 247
Query: 386 LTPAGLAIKN--GQLECVRWMVSETEAIAELSC-SKDFPSLIHYAGCYGQEKILLWLLQF 442
TP A + G L C+ +V+ A+++ SKD S +H +G+ L+Q
Sbjct: 248 FTPLHFAAASTHGAL-CLELLVNNG---ADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQ- 302
Query: 443 MQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G +D VD+DGN+ +HVA+++G+ I TL GA+ P A H
Sbjct: 303 ---NGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAH 359
Query: 503 TLCSRYLV 510
+ C R L+
Sbjct: 360 SDCCRKLL 367
Score = 51.2 bits (121), Expect = 4e-06
Identities = 40/137 (29%), Positives = 64/137 (46%), Gaps = 8/137 (5%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D++GN LH+AA GH E L + G D + + P LA N +C R ++S
Sbjct: 311 DKDGNTPLHVAARYGH-ELLINTLRTSGADTA-KCGIHSMFPLHLAALNAHSDCCRKLLS 368
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
I + K + +H A G + + + +Q G + D+ G + +H A+
Sbjct: 369 SGFEID--TPDKFGRTCLHAAAAGGNVECI----KLLQSSGADFHKKDKCGRTPLHYAAA 422
Query: 467 HGYLGCIQTLVEYGANV 483
+ + CI+TLV GANV
Sbjct: 423 NCHFHCIETLVTTGANV 439
Score = 48.1 bits (113), Expect = 4e-05
Identities = 56/246 (22%), Positives = 96/246 (39%), Gaps = 39/246 (15%)
Query: 302 NRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQG 361
N+T + SE L++ + + KE + L L D I D+ G N +H AA+ G
Sbjct: 461 NKTILGNAHDNSEELERARELKE--KEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYG 518
Query: 362 HAECLQ----------------------HLTSLMGEDC-----------LNERNTEKLTP 388
H +CL+ HL + G L+ R+ + T
Sbjct: 519 HRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTA 578
Query: 389 AGLAIKNGQLECVRWMVSETEAI-AELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQG 447
LA G ECV +++ +I + + +K P +A + L LL + +
Sbjct: 579 LDLAAFKGHTECVEALINPGASIFVKDNVTKRTPL---HASVINGHTLCLRLLLEIADNP 635
Query: 448 ISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSR 507
++D D G + + +A +G++ + L+E ANV + G GH C +
Sbjct: 636 EAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQ 695
Query: 508 YLVVVE 513
L+ E
Sbjct: 696 MLLEQE 701
Score = 45.1 bits (105), Expect = 3e-04
Identities = 42/167 (25%), Positives = 66/167 (39%), Gaps = 10/167 (5%)
Query: 345 IHDENGNNLLHIAASQGHAECLQHLTSLMGE-DCLNERNTEKLTPAGLAIKNGQLECVRW 403
I ++G + LH+ A G Q L GE DC+++ TP +A + G +
Sbjct: 276 IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN---TPLHVAARYGHELLINT 332
Query: 404 MVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHV 463
+ + A+ FP +H A LL G +D D+ G + +H
Sbjct: 333 LRTSGADTAKCGIHSMFP--LHLAALNAHSDCCRKLLS----SGFEIDTPDKFGRTCLHA 386
Query: 464 ASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
A+ G + CI+ L GA+ ++ G P A H C LV
Sbjct: 387 AAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV 433
Score = 43.9 bits (102), Expect = 7e-04
Identities = 42/161 (26%), Positives = 66/161 (40%), Gaps = 16/161 (9%)
Query: 347 DENGNNLLHIAASQGHAECLQHL--TSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
D G LH AA++GHA L L +L EDC + N + TP A NG C+
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDN-QGYTPLHWACYNGNENCI--- 763
Query: 405 VSETEAIAELSCSKDFP----SLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSA 460
E + E C + F + +H A LL + +S D G +
Sbjct: 764 ----EVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCR--DDKGRTP 817
Query: 461 VHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQG 501
+ A+ ++ C+Q L+ + A V +++G+ A G
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENG 858
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 3/117 (2%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
SLL ++ D+ G L AA H ECLQ L L +N + T +
Sbjct: 796 SLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLL--LRHSAPVNAVDNSGKTALMM 853
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGI 448
A +NGQ V +V+ +A + KD + +H A G EK L +L +Q++ +
Sbjct: 854 AAENGQAGAVDILVNSAQADLTVK-DKDLNTPLHLACSKGHEKCALLILDKIQDESL 909
Score = 41.2 bits (95), Expect = 0.004
Identities = 51/223 (22%), Positives = 89/223 (39%), Gaps = 34/223 (15%)
Query: 331 ISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHL---------TSLMGEDCLN-- 379
I LL AD K D+ G LH AA+ H C++ L T G L+
Sbjct: 396 IKLLQSSGADFHKK--DKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453
Query: 380 ---------------ERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLI 424
N+E+L A + C+ +++ + +A + + + S I
Sbjct: 454 AASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLL-QNDANPSIRDKEGYNS-I 511
Query: 425 HYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGN-SAVHVASQHGYLGCIQTLVEYGANV 483
HYA YG + L LL+ +E D S +H+A+ +G+ ++ L++ ++
Sbjct: 512 HYAAAYGHRQCLELLLE---RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDL 568
Query: 484 TMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLT 526
+++ G A +GHT C L+ + + V K T
Sbjct: 569 DIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRT 611
Score = 33.5 bits (75), Expect = 0.94
Identities = 19/55 (34%), Positives = 32/55 (58%), Gaps = 2/55 (3%)
Query: 329 GQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAEC-LQHLTSLMGEDCLNERN 382
G + +L + A +L + D++ N LH+A S+GH +C L L + E +NE+N
Sbjct: 861 GAVDILVNSAQADLT-VKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINEKN 914
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/173 (29%), Positives = 84/173 (48%), Gaps = 7/173 (4%)
Query: 338 AADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQ 397
+++N K+ G LH+AASQGH + +Q L + N E+ TP LA++NGQ
Sbjct: 67 SSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADP--NATTLEETTPLFLAVENGQ 124
Query: 398 LECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDG 457
++ +R ++ + + SL H A +I+ LL+ +G + + D G
Sbjct: 125 IDVLRLLLQHGANVNGSHSMCGWNSL-HQASFQENAEIIKLLLR----KGANKECQDDFG 179
Query: 458 NSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ + VA+Q+G L + L+ GANV Q P A ++GHT C L+
Sbjct: 180 ITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 232
Score = 39.7 bits (91), Expect = 0.013
Identities = 58/226 (25%), Positives = 92/226 (40%), Gaps = 34/226 (15%)
Query: 264 SDPHGRKVEKTTP------DCQLRAFHLQ-SSAAESKPEEQVSGLNRTSSQGPEERSEYL 316
+DP+ +E+TTP + Q+ L A + G N +E +E +
Sbjct: 103 ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEII 162
Query: 317 KKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGED 376
K LL A+ + D+ G L +AA G E L L S
Sbjct: 163 K---------------LLLRKGANK--ECQDDFGITPLFVAAQYGKLESLSILISSGAN- 204
Query: 377 CLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSL-IHYAGCYGQEKI 435
+N + +K TP +A + G +CV ++S + A +L C++D L IH A G KI
Sbjct: 205 -VNCQALDKATPLFIAAQEGHTKCVELLLS-SGADPDLYCNEDSWQLPIHAAAQMGHTKI 262
Query: 436 LLWLLQFMQEQ-GISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG 480
L L+ L++V S V+ A G+ C++ L+ G
Sbjct: 263 LDLLIPLTNRACDTGLNKV-----SPVYSAVFGGHEDCLEILLRNG 303
Score = 32.3 bits (72), Expect = 2.1
Identities = 25/87 (28%), Positives = 39/87 (44%), Gaps = 7/87 (8%)
Query: 419 DFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVE 478
D S + A G K+L LL+ +G S+D D G +H A+ H + C+Q L+
Sbjct: 9 DTCSTVGLAAREGNVKVLRKLLK----KGRSVDVADNRGWMPIHEAAYHNSVECLQMLIN 64
Query: 479 YGAN---VTMQNHAGEKPSQSAERQGH 502
++ + M+ G A QGH
Sbjct: 65 ADSSENYIKMKTFEGFCALHLAASQGH 91
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 63.2 bits (152), Expect = 1e-09
Identities = 53/187 (28%), Positives = 88/187 (47%), Gaps = 9/187 (4%)
Query: 316 LKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGE 375
++K K + IV L+ L ++D D +G +LLH+A G EC + L L+
Sbjct: 405 VQKKKLVDAIVSGDTSKLMKILQPQDVDLALD-SGASLLHLAVEAGQEECAKWL--LLNN 461
Query: 376 DCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKI 435
N N TP +A++ V +++ I+ + +D + +H+A G E
Sbjct: 462 ANPNLSNRRGSTPLHMAVERRVRGVVELLLARK--ISVNAKDEDQWTALHFAAQNGDESS 519
Query: 436 LLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQ 495
LL E+ S++EVD +G + +HVA QHG ++ L+ G +V++Q P
Sbjct: 520 TRLLL----EKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLH 575
Query: 496 SAERQGH 502
A QGH
Sbjct: 576 YAAWQGH 582
Score = 53.5 bits (127), Expect = 9e-07
Identities = 65/290 (22%), Positives = 120/290 (41%), Gaps = 27/290 (9%)
Query: 289 AAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVK-EGQISLLPHLAA----DNLD 343
+ +K E+Q + L+ + G E + L + + +N V EG+ + H+A +N+
Sbjct: 496 SVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPM--HVACQHGQENIV 553
Query: 344 KIHDENGNNL----------LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAI 393
+I G ++ LH AA QGH ++ L G +N + + TP LA
Sbjct: 554 RILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVS-VNAQTLDGRTPLHLAA 612
Query: 394 KNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEV 453
+ G R ++ + S P +H A G LL +G + +
Sbjct: 613 QRGHYRVARILIDLCSDVNVCSLLAQTP--LHVAAETGHTSTARLLLH----RGAGKEAM 666
Query: 454 DQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV--- 510
DG +A+H+A+++G+L ++ LVE A+V + + A GH+ LV
Sbjct: 667 TSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSAD 726
Query: 511 VVETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSS 560
V++ + L Q + L++ L++ K +G P++
Sbjct: 727 VIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHINLQSLKFQGGHGPAA 776
Score = 39.7 bits (91), Expect = 0.013
Identities = 33/120 (27%), Positives = 59/120 (49%), Gaps = 6/120 (5%)
Query: 391 LAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISL 450
LA++ GQ EC +W++ A LS + L H A E+ + +++ + + IS+
Sbjct: 444 LAVEAGQEECAKWLLLNN-ANPNLSNRRGSTPL-HMA----VERRVRGVVELLLARKISV 497
Query: 451 DEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ D+D +A+H A+Q+G + L+E A+V + G P A + G R L+
Sbjct: 498 NAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILL 557
>gi|155969701 espin-like [Homo sapiens]
Length = 1005
Score = 63.2 bits (152), Expect = 1e-09
Identities = 50/197 (25%), Positives = 82/197 (41%), Gaps = 37/197 (18%)
Query: 345 IHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
+ G LH AA G CL+ LT+ G +N R +P LA + G L +++
Sbjct: 132 LETREGARPLHHAAVSGDLTCLKLLTAAHGSS-VNRRTRSGASPLYLACQEGHLHLAQFL 190
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
V + A L + D S +H A G +++WL+ F I L D +G +A+H A
Sbjct: 191 VKDCGADVHLR-ALDGMSALHAAAARGHYSLVVWLVTFTD---IGLTARDNEGATALHFA 246
Query: 465 S--------------------------------QHGYLGCIQTLVEYGANVTMQNHAGEK 492
+ ++G + C QTLV + + ++++ G
Sbjct: 247 ARGGHTPILDRLLLMGTPILRDSWGGTPLHDAAENGQMECCQTLVSHHVDPSLRDEDGYT 306
Query: 493 PSQSAERQGHTLCSRYL 509
+ AE GH C++YL
Sbjct: 307 AADLAEYHGHRDCAQYL 323
Score = 57.0 bits (136), Expect = 8e-08
Identities = 53/191 (27%), Positives = 86/191 (45%), Gaps = 17/191 (8%)
Query: 327 KEGQISLLPHLAADNL--DKIHDENGNNLLHIAASQGHAECLQHL---TSLMGEDCLNER 381
K+G ++ L L I D G L+H A GH +C++ L L G N+R
Sbjct: 11 KDGDVATLERLLEAGALGPGITDALGAGLVHHATRAGHLDCVKFLVQRAQLPG----NQR 66
Query: 382 NTEKLTPAGLAIKNGQLECVRWMVSETE-AIAELSCSKDFPSLIHYAGCYGQEKILLWLL 440
TPA A G L + W+V E + + S P +H A +G ++ WLL
Sbjct: 67 AHNGATPAHDAAATGSLAELCWLVREGGCGLQDQDASGVSP--LHLAARFGHPVLVEWLL 124
Query: 441 QFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTL-VEYGANVTMQNHAGEKPSQSAER 499
+G S ++G +H A+ G L C++ L +G++V + +G P A +
Sbjct: 125 ----HEGHSATLETREGARPLHHAAVSGDLTCLKLLTAAHGSSVNRRTRSGASPLYLACQ 180
Query: 500 QGHTLCSRYLV 510
+GH +++LV
Sbjct: 181 EGHLHLAQFLV 191
Score = 37.7 bits (86), Expect = 0.050
Identities = 40/139 (28%), Positives = 51/139 (36%), Gaps = 42/139 (30%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D G LH AA GH L L LMG L R++ TP A +NGQ+EC + +VS
Sbjct: 236 DNEGATALHFAARGGHTPILDRLL-LMGTPIL--RDSWGGTPLHDAAENGQMECCQTLVS 292
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
PSL D+DG +A +A
Sbjct: 293 HHVD----------PSLR-----------------------------DEDGYTAADLAEY 313
Query: 467 HGYLGCIQTLVEYGANVTM 485
HG+ C Q L E V +
Sbjct: 314 HGHRDCAQYLREVAQPVPL 332
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 62.8 bits (151), Expect = 1e-09
Identities = 121/566 (21%), Positives = 217/566 (38%), Gaps = 95/566 (16%)
Query: 320 KSILNIVK-EGQISLLPHLAADNLDKIH-DENGNNLLHIAASQGHAECLQHLTSLMGEDC 377
+++L+I +G + ++ L LD+ H D+ G LH+AA +GH + L
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGART- 873
Query: 378 LNERNTEKLTPAGLAIKNGQLECVRWMVSETEAI-------------AELSCSKDFPSLI 424
NE + + P LA + G +CV+ ++ I A L +D L+
Sbjct: 874 -NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELL 932
Query: 425 HYAGCYGQEK---------IL-----LWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYL 470
G K IL L + ++ E G +++ D +G +A+HV+ G++
Sbjct: 933 FSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHM 992
Query: 471 GCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT-----LCSRYLVVVETC------MSLA 519
+Q L+ Y A+V ++ QSA QGH L VV TC + +A
Sbjct: 993 EMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052
Query: 520 SQV--VKLTKQLKE------------QTVERVTLQNQLQQFLEAQKSEGKSLPS--SPSS 563
+Q + + + L E +T RV +N Q ++ + G S + SPS
Sbjct: 1053 AQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSP 1112
Query: 564 PSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARP-------KAKDEDS 616
+ + Q S ++ + G G G + S R P + E
Sbjct: 1113 VHTMEQKPLQSLSSKVQSLTIKSNSSGSTGG----GDMQPSLRGLPNGPTHAFSSPSESP 1168
Query: 617 DKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLS 676
D + + + ++ + + SL +S+ ++ +P++ L+ Q+ Q SL
Sbjct: 1169 DSTVDRQKSSLSNNSLKSSKNSSLR---TTSSTATAQTVPIDSFH-NLSFTEQIQQHSLP 1224
Query: 677 ESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFS 736
S + + TT P E + S +S T AS G + S
Sbjct: 1225 RSRSRQSIVSPSSTTQSLGQSHNSPSSEFEWSQVKPSLKS--------TKASKGGK---S 1273
Query: 737 IKASKSLDGHSPSPTSESSEPDL----ESQYPGSGSIPPNQPSGDPQQPSPDS------- 785
++KS + S SS+P + +Q+ G I + + P+Q +S
Sbjct: 1274 ENSAKSGSAGKKAKQSNSSQPKVLEYEMTQFDRRGPIAKSGTAAPPKQMPAESQCKIMIP 1333
Query: 786 TAAQKVATSPKSALKSPSSKRRTSQN 811
+A Q++ S + L S + +N
Sbjct: 1334 SAQQEIGRSQQQFLIHQQSGEQKKRN 1359
Score = 62.0 bits (149), Expect = 2e-09
Identities = 125/568 (22%), Positives = 214/568 (37%), Gaps = 103/568 (18%)
Query: 328 EGQISLLPHLAADNLDKIH-DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKL 386
EG + ++ L D H D NG L AAS GHA + T L ++ ++E
Sbjct: 758 EGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVN--TLLFWGAAVDSIDSEGR 815
Query: 387 TPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQ 446
T +A G +E VR ++ + E + +H A G I L+ EQ
Sbjct: 816 TVLSIASAQGNVEVVRTLLDR--GLDENHRDDAGWTPLHMAAFEGHRLICEALI----EQ 869
Query: 447 GISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCS 506
G +E+D DG +ASQ G+ C+Q L+E +N+ + + G + A +GH
Sbjct: 870 GARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR--- 926
Query: 507 RYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQNQL---QQFLEAQKSEGKSLPSSPSS 563
+VE S + V T+ + L+NQL + FLE G ++ +S +
Sbjct: 927 ---DIVELLFSHGAD-VNCKDADGRPTLYILALENQLTMAEYFLE----NGANVEAS-DA 977
Query: 564 PSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKD--------ED 615
A S W+ G E +QVL + A A K +
Sbjct: 978 EGRTALHVSCWQ--------------GHMEMVQVLIAYHADVNAADNEKRSALQSAAWQG 1023
Query: 616 SDKILRQLLGK-EISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRS 674
K+++ L+ + ++ C Q +L I ++ + + ++
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATAL-------------CIAAQEGHIDVVQV------- 1063
Query: 675 LSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMD-------SAESLHLMIKKHTLA 727
L E D N+++ T +R A + I++ +E S +H M +K +
Sbjct: 1064 LLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTMEQKPLQS 1123
Query: 728 SGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTA 787
+ +IK++ S S +P L G P P + SPDST
Sbjct: 1124 LSSKVQSLTIKSNS-----SGSTGGGDMQPSLRGLPNG-----PTHAFSSPSE-SPDSTV 1172
Query: 788 AQKVATSPKSALKSP--SSKRRTSQNLKLR---------VTFEEPVVQMEQPSLELNGEK 836
++ ++ ++LKS SS R TS + ++F E + Q P +
Sbjct: 1173 DRQKSSLSNNSLKSSKNSSLRTTSSTATAQTVPIDSFHNLSFTEQIQQHSLP-------R 1225
Query: 837 DKDKGRTLQRTSTSNESGDQLKRPFGAF 864
+ + + +ST+ G P F
Sbjct: 1226 SRSRQSIVSPSSTTQSLGQSHNSPSSEF 1253
Score = 48.1 bits (113), Expect = 4e-05
Identities = 43/188 (22%), Positives = 84/188 (44%), Gaps = 14/188 (7%)
Query: 329 GQISLLPHLAADNLDKIHDE-NGNNLLHIAA-----SQGHAECLQHLTSLMGEDCLNERN 382
G ++ HL + H++ +G L +AA S+GHA + L E ++ +
Sbjct: 688 GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE--VDHCD 745
Query: 383 TEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQF 442
+ +TP +A G ++ V ++ + + P L A G ++ LL +
Sbjct: 746 KDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLA--AASMGHASVVNTLLFW 803
Query: 443 MQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G ++D +D +G + + +AS G + ++TL++ G + ++ AG P A +GH
Sbjct: 804 ----GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGH 859
Query: 503 TLCSRYLV 510
L L+
Sbjct: 860 RLICEALI 867
Score = 43.5 bits (101), Expect = 0.001
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 16/185 (8%)
Query: 331 ISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAG 390
++LL H A N D G L AA GH E ++HL E +N + + T
Sbjct: 661 LNLLQHGAEVNKA---DNEGRTALIAAAYMGHREIVEHLLDHGAE--VNHEDVDGRTALS 715
Query: 391 LA-----IKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQE 445
+A G V ++ + C KD + + A G ++ LL E
Sbjct: 716 VAALCVPASKGHASVVSLLIDRGAEVDH--CDKDGMTPLLVAAYEGHVDVVDLLL----E 769
Query: 446 QGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLC 505
G +D D +G + + A+ G+ + TL+ +GA V + G A QG+
Sbjct: 770 GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEV 829
Query: 506 SRYLV 510
R L+
Sbjct: 830 VRTLL 834
Score = 42.7 bits (99), Expect = 0.002
Identities = 38/164 (23%), Positives = 74/164 (45%), Gaps = 8/164 (4%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D++G L +AA +GH + + L L G ++ + TP A G V ++
Sbjct: 745 DKDGMTPLLVAAYEGHVDVVDLL--LEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLF 802
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
A+ S + +++ A G +++ LL ++G+ + D G + +H+A+
Sbjct: 803 WGAAVD--SIDSEGRTVLSIASAQGNVEVVRTLL----DRGLDENHRDDAGWTPLHMAAF 856
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+ + L+E GA ++ G P A ++GH C + L+
Sbjct: 857 EGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILL 900
Score = 41.6 bits (96), Expect = 0.003
Identities = 40/156 (25%), Positives = 66/156 (42%), Gaps = 8/156 (5%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D NG LL AA G + + L S G D L + TP LA + G + V ++
Sbjct: 542 DSNGRTLLANAAYSGSLDVVNLLVS-RGAD-LEIEDAHGHTPLTLAARQGHTKVVNCLIG 599
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
I +D + + A G +++ LL G+ +D D D +A+ A+
Sbjct: 600 CGANINHTD--QDGWTALRSAAWGGHTEVVSALLY----AGVKVDCADADSRTALRAAAW 653
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G+ + L+++GA V ++ G +A GH
Sbjct: 654 GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGH 689
Score = 39.7 bits (91), Expect = 0.013
Identities = 19/64 (29%), Positives = 36/64 (56%)
Query: 440 LQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAER 499
++ + + G S+++ D +G + + A+ G L + LV GA++ +++ G P A R
Sbjct: 528 IRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAAR 587
Query: 500 QGHT 503
QGHT
Sbjct: 588 QGHT 591
Score = 32.0 bits (71), Expect = 2.7
Identities = 16/65 (24%), Positives = 33/65 (50%)
Query: 439 LLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAE 498
++ + +G L+ D G++ + +A++ G+ + L+ GAN+ + G +SA
Sbjct: 560 VVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAA 619
Query: 499 RQGHT 503
GHT
Sbjct: 620 WGGHT 624
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 62.4 bits (150), Expect = 2e-09
Identities = 48/157 (30%), Positives = 77/157 (49%), Gaps = 7/157 (4%)
Query: 354 LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAE 413
LH+AASQGH + +Q L + N E+ TP LA++NGQ++ +R ++ +
Sbjct: 10 LHLAASQGHWKIVQILLEAGADP--NATTLEETTPLFLAVENGQIDVLRLLLQHGANVNG 67
Query: 414 LSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCI 473
+ SL H A +I+ LL+ +G + + D G + + VA+Q+G L +
Sbjct: 68 SHSMCGWNSL-HQASFQENAEIIKLLLR----KGANKECQDDFGITPLFVAAQYGKLESL 122
Query: 474 QTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
L+ GANV Q P A ++GHT C L+
Sbjct: 123 SILISSGANVNCQALDKATPLFIAAQEGHTKCVELLL 159
Score = 39.7 bits (91), Expect = 0.013
Identities = 58/226 (25%), Positives = 92/226 (40%), Gaps = 34/226 (15%)
Query: 264 SDPHGRKVEKTTP------DCQLRAFHLQ-SSAAESKPEEQVSGLNRTSSQGPEERSEYL 316
+DP+ +E+TTP + Q+ L A + G N +E +E +
Sbjct: 30 ADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEII 89
Query: 317 KKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGED 376
K LL A+ + D+ G L +AA G E L L S
Sbjct: 90 K---------------LLLRKGANK--ECQDDFGITPLFVAAQYGKLESLSILISSGAN- 131
Query: 377 CLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSL-IHYAGCYGQEKI 435
+N + +K TP +A + G +CV ++S + A +L C++D L IH A G KI
Sbjct: 132 -VNCQALDKATPLFIAAQEGHTKCVELLLS-SGADPDLYCNEDSWQLPIHAAAQMGHTKI 189
Query: 436 LLWLLQFMQEQ-GISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYG 480
L L+ L++V S V+ A G+ C++ L+ G
Sbjct: 190 LDLLIPLTNRACDTGLNKV-----SPVYSAVFGGHEDCLEILLRNG 230
>gi|239754056 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 524
Score = 60.8 bits (146), Expect = 5e-09
Identities = 73/322 (22%), Positives = 137/322 (42%), Gaps = 38/322 (11%)
Query: 220 KASAVIHDQHKLS-------TEETEISPPLVKCGSAYEPENQS-KDFLNKTFSDPHGRKV 271
KA + D+H L+ + E+ LVK G+ +NQ L+ H R V
Sbjct: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
Query: 272 EKTTPDCQLR-----------AFHLQSSAAESKPEEQVSGLNRTSSQGPEER-----SEY 315
E D L+ F L + + E+++ LN +S+ + + +
Sbjct: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA 243
Query: 316 LKKVK----SILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTS 371
L K+K SI + EG S ++ ++ + + GN LH+AA GH+ +Q L +
Sbjct: 244 LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLL--QGGNTALHLAAKHGHSPAVQVLLA 301
Query: 372 LMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYG 431
+ +NE N ++ +A +NG V +++SE + + K+ P +H
Sbjct: 302 QWQD--INEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP--LHLVVINN 357
Query: 432 QEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGE 491
++ LL + +D ++Q + +HVA+ G + ++TL++ G ++ + G+
Sbjct: 358 HITVVNSLLSAQHD----IDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGK 413
Query: 492 KPSQSAERQGHTLCSRYLVVVE 513
A R H+L L+ E
Sbjct: 414 TALAVASRSNHSLVVGMLIKAE 435
Score = 33.5 bits (75), Expect = 0.94
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 440 LQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAER 499
+ F+ + +D D+ G + +H+A+ G L + LV+ GA+ +N G A +
Sbjct: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQ 176
Query: 500 QGHTLCSRYLV 510
H YL+
Sbjct: 177 SNHVRIVEYLI 187
>gi|239748583 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 524
Score = 60.8 bits (146), Expect = 5e-09
Identities = 73/322 (22%), Positives = 137/322 (42%), Gaps = 38/322 (11%)
Query: 220 KASAVIHDQHKLS-------TEETEISPPLVKCGSAYEPENQS-KDFLNKTFSDPHGRKV 271
KA + D+H L+ + E+ LVK G+ +NQ L+ H R V
Sbjct: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
Query: 272 EKTTPDCQLR-----------AFHLQSSAAESKPEEQVSGLNRTSSQGPEER-----SEY 315
E D L+ F L + + E+++ LN +S+ + + +
Sbjct: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA 243
Query: 316 LKKVK----SILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTS 371
L K+K SI + EG S ++ ++ + + GN LH+AA GH+ +Q L +
Sbjct: 244 LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLL--QGGNTALHLAAKHGHSPAVQVLLA 301
Query: 372 LMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYG 431
+ +NE N ++ +A +NG V +++SE + + K+ P +H
Sbjct: 302 QWQD--INEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP--LHLVVINN 357
Query: 432 QEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGE 491
++ LL + +D ++Q + +HVA+ G + ++TL++ G ++ + G+
Sbjct: 358 HITVVNSLLSAQHD----IDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGK 413
Query: 492 KPSQSAERQGHTLCSRYLVVVE 513
A R H+L L+ E
Sbjct: 414 TALAVASRSNHSLVVGMLIKAE 435
Score = 33.5 bits (75), Expect = 0.94
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 440 LQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAER 499
+ F+ + +D D+ G + +H+A+ G L + LV+ GA+ +N G A +
Sbjct: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQ 176
Query: 500 QGHTLCSRYLV 510
H YL+
Sbjct: 177 SNHVRIVEYLI 187
>gi|239742602 PREDICTED: ankyrin repeat and death domain containing
1B [Homo sapiens]
Length = 607
Score = 60.8 bits (146), Expect = 5e-09
Identities = 73/322 (22%), Positives = 137/322 (42%), Gaps = 38/322 (11%)
Query: 220 KASAVIHDQHKLS-------TEETEISPPLVKCGSAYEPENQS-KDFLNKTFSDPHGRKV 271
KA + D+H L+ + E+ LVK G+ +NQ L+ H R V
Sbjct: 124 KARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQSNHVRIV 183
Query: 272 EKTTPDCQLR-----------AFHLQSSAAESKPEEQVSGLNRTSSQGPEER-----SEY 315
E D L+ F L + + E+++ LN +S+ + + +
Sbjct: 184 EYLIQDLHLKDLNQPDEKGRKPFLLAAERGHVEMIEKLTFLNLHTSEKDKIQWSTLWTAA 243
Query: 316 LKKVK----SILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTS 371
L K+K SI + EG S ++ ++ + + GN LH+AA GH+ +Q L +
Sbjct: 244 LTKMKTSRNSIAALTIEGACSPGTGVSTSSVSLL--QGGNTALHLAAKHGHSPAVQVLLA 301
Query: 372 LMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYG 431
+ +NE N ++ +A +NG V +++SE + + K+ P +H
Sbjct: 302 QWQD--INEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESP--LHLVVINN 357
Query: 432 QEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGE 491
++ LL + +D ++Q + +HVA+ G + ++TL++ G ++ + G+
Sbjct: 358 HITVVNSLLSAQHD----IDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGK 413
Query: 492 KPSQSAERQGHTLCSRYLVVVE 513
A R H+L L+ E
Sbjct: 414 TALAVASRSNHSLVVGMLIKAE 435
Score = 33.5 bits (75), Expect = 0.94
Identities = 18/71 (25%), Positives = 33/71 (46%)
Query: 440 LQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAER 499
+ F+ + +D D+ G + +H+A+ G L + LV+ GA+ +N G A +
Sbjct: 117 VDFLLKHKARVDVADKHGLTVIHLAAWSGSLEVMLMLVKAGADQRAKNQDGMSALHFATQ 176
Query: 500 QGHTLCSRYLV 510
H YL+
Sbjct: 177 SNHVRIVEYLI 187
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 59.7 bits (143), Expect = 1e-08
Identities = 50/180 (27%), Positives = 85/180 (47%), Gaps = 22/180 (12%)
Query: 354 LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAE 413
L +AA +G E + L + + + TP LA G L V+ ++ +A +
Sbjct: 14 LLVAAYKGQTENVVQLINKGARVAVTKHGR---TPLHLAANKGHLPVVQILL---KAGCD 67
Query: 414 LSCSKDFP-SLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGC 472
L D + +H A G +I+ L+ +G +LD D+DGN+A+H AS HG+
Sbjct: 68 LDVQDDGDQTALHRATVVGNTEIIAALIH----EGCALDRQDKDGNTALHEASWHGFSQS 123
Query: 473 IQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVV-----------ETCMSLASQ 521
+ LV+ GANV +N AG A + H+ +R L++ +TC+ +A++
Sbjct: 124 AKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHVAAR 183
Score = 55.8 bits (133), Expect = 2e-07
Identities = 63/256 (24%), Positives = 116/256 (45%), Gaps = 26/256 (10%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D++GN LH A+ G ++ + L G + L +N T LA +N + R ++
Sbjct: 105 DKDGNTALHEASWHGFSQSAKLLVKA-GANVL-AKNKAGNTALHLACQNSHSQSTRVLLL 162
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
+ + D + +H A Y I+ LL S+ E +Q G++A+HVA+
Sbjct: 163 AGSRADLKNNAGD--TCLHVAARYNHLSIIRLLLTAF----CSVHEKNQAGDTALHVAAA 216
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLT 526
+ + L+E GA+ T+ N+AG+ P ++A + V ++ A QV++ +
Sbjct: 217 LNHKKVAKILLEAGADTTIVNNAGQTPLETARYHNNP-------EVALLLTKAPQVLRFS 269
Query: 527 K-QLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSS--PASRKSQWK-------- 575
+ + + ER+ + + Q + ++ K S+ +PSS +RK + +
Sbjct: 270 RGRSLRKKRERLKEERRAQSVPRDEVAQSKGSVSAGDTPSSEQAVARKEEAREEFLSASP 329
Query: 576 SPDADDDSVAKSKPGV 591
P A DD KS+P V
Sbjct: 330 EPRAKDDRRRKSRPKV 345
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 59.3 bits (142), Expect = 2e-08
Identities = 46/177 (25%), Positives = 78/177 (44%), Gaps = 19/177 (10%)
Query: 341 NLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLEC 400
NLD + D G L +A +G EC++ LT+ G L + K TP A +G +
Sbjct: 610 NLD-VRDHKGRTALFLATERGSTECVEVLTA-HGASALIKERKRKWTPLHAAAASGHTDS 667
Query: 401 VRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQ-------FMQEQGISLDEV 453
+ ++ E A+++ D YGQ ++L ++ + E+G + D
Sbjct: 668 LHLLIDSGER-ADITDVMD---------AYGQTPLMLAIMNGHVDCVHLLLEKGSTADAA 717
Query: 454 DQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
D G +A+H + G C+ L+++ A V ++ G P A GHT R L+
Sbjct: 718 DLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL 774
Score = 57.8 bits (138), Expect = 5e-08
Identities = 55/181 (30%), Positives = 83/181 (45%), Gaps = 14/181 (7%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
+L P L++ N + D +G + LH A GH E + L L LN + ++ P
Sbjct: 125 ALAPLLSSLN---VADRSGRSALHHAVHSGHLETVNLL--LNKGASLNVCDKKERQPLHW 179
Query: 392 AIKNGQLECVRWMVSETEAIAELSC-SKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISL 450
A G LE ++ +V+ A+L C + L+H A GQ +++ +LL+ G +
Sbjct: 180 AAFLGHLEVLKLLVARG---ADLGCKDRKGYGLLHTAAASGQIEVVKYLLR----MGAEI 232
Query: 451 DEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQ-SAERQGHTLCSRYL 509
DE + GN+A+H+A G LV GANV N G P +A LC L
Sbjct: 233 DEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELL 292
Query: 510 V 510
V
Sbjct: 293 V 293
Score = 53.5 bits (127), Expect = 9e-07
Identities = 52/198 (26%), Positives = 77/198 (38%), Gaps = 32/198 (16%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D G LH AAS G+ ECL L S G D L R+ TP A NG +C +V+
Sbjct: 420 DNLGRTCLHAAASGGNVECLNLLLS-SGAD-LRRRDKFGRTPLHYAAANGSYQCAVTLVT 477
Query: 407 ETEAIAELSCSKDFPSLIHYAGCY------------------------GQEKILLWLLQF 442
+ E C P +HYA + K + L+F
Sbjct: 478 AGAGVNEADCKGCSP--LHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEF 535
Query: 443 MQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANV--TMQNHAGEKPSQSAERQ 500
+ + G D+ G +AVH A+ +G ++ L+E N +++ P A
Sbjct: 536 LLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYN 595
Query: 501 GHTLCSRYLVVVETCMSL 518
GH C + ET ++L
Sbjct: 596 GH--CEALKTLAETLVNL 611
Score = 49.7 bits (117), Expect = 1e-05
Identities = 49/177 (27%), Positives = 74/177 (41%), Gaps = 8/177 (4%)
Query: 329 GQISLLPHLAADNLDK-IHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLT 387
G + +L L A D D G LLH AA+ G E +++L + E ++E N T
Sbjct: 184 GHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE--IDEPNAFGNT 241
Query: 388 PAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQG 447
+A GQ + V + A K F L H A + L LL G
Sbjct: 242 ALHIACYLGQ-DAVAIELVNAGANVNQPNDKGFTPL-HVAAVSTNGALCLELLV---NNG 296
Query: 448 ISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
++ ++G S +H+A+ HG Q L++ G+ + + G P A R GH L
Sbjct: 297 ADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHEL 353
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/164 (23%), Positives = 65/164 (39%), Gaps = 23/164 (14%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D+ GN LH+AA GH E L G D R + P LA+ G +C R ++S
Sbjct: 336 DKFGNTPLHVAARYGH-ELLISTLMTNGADTAR-RGIHDMFPLHLAVLFGFSDCCRKLLS 393
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
+ + +S + + + G ++ D G + +H A+
Sbjct: 394 SGQLYSIVSSLSN---------------------EHVLSAGFDINTPDNLGRTCLHAAAS 432
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G + C+ L+ GA++ ++ G P A G C+ LV
Sbjct: 433 GGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV 476
Score = 45.1 bits (105), Expect = 3e-04
Identities = 38/149 (25%), Positives = 68/149 (45%), Gaps = 6/149 (4%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D G LH AA + L+ L E +N + T A +NGQ V +++
Sbjct: 855 DAKGRTPLHAAAFADNVSGLRMLLQHQAE--VNATDHTGRTALMTAAENGQTAAVEFLLY 912
Query: 407 ETEA-IAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVAS 465
+A + L +K+ + +H A G EK L +L Q+ G+ ++ + +H+A+
Sbjct: 913 RGKADLTVLDENKN--TALHLACSKGHEKCALMILAETQDLGL-INATNSALQMPLHIAA 969
Query: 466 QHGYLGCIQTLVEYGANVTMQNHAGEKPS 494
++G +Q L+ +GA V + G P+
Sbjct: 970 RNGLASVVQALLSHGATVLAVDEEGHTPA 998
Score = 41.6 bits (96), Expect = 0.003
Identities = 50/233 (21%), Positives = 95/233 (40%), Gaps = 13/233 (5%)
Query: 337 LAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNG 396
L+ D LD D +G + +H A+ GH +CL+ L+ + TP A+ N
Sbjct: 778 LSTDPLDAGVDYSGYSPMHWASYTGHEDCLE---LLLEHSPFSYLEGNPFTPLHCAVINN 834
Query: 397 QLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQD 456
Q ++ A S + +H A L LLQ E ++ D
Sbjct: 835 QDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAE----VNATDHT 890
Query: 457 GNSAVHVASQHGYLGCIQTLVEYG-ANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETC 515
G +A+ A+++G ++ L+ G A++T+ + A +GH C+ L+++
Sbjct: 891 GRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCA--LMILAET 948
Query: 516 MSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPA 568
L ++ T + + + +N L ++A S G ++ + +PA
Sbjct: 949 QDLG--LINATNSALQMPL-HIAARNGLASVVQALLSHGATVLAVDEEGHTPA 998
Score = 40.0 bits (92), Expect = 0.010
Identities = 36/161 (22%), Positives = 64/161 (39%), Gaps = 42/161 (26%)
Query: 345 IHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNE-RNTEKLTPAGLAIKNGQLECVRW 403
+ D G +H AA+ G+ + L+ L M +CL + +T ++P LA NG E
Sbjct: 545 LRDRQGYTAVHYAAAYGNRQNLELLLE-MSFNCLEDVESTIPVSPLHLAAYNGHCEA--- 600
Query: 404 MVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHV 463
L+ + E ++LD D G +A+ +
Sbjct: 601 ------------------------------------LKTLAETLVNLDVRDHKGRTALFL 624
Query: 464 ASQHGYLGCIQTLVEYGANVTMQNHAGE-KPSQSAERQGHT 503
A++ G C++ L +GA+ ++ + P +A GHT
Sbjct: 625 ATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHT 665
Score = 38.9 bits (89), Expect = 0.022
Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 1/78 (1%)
Query: 347 DENGNNLLHIAASQGHAEC-LQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMV 405
DEN N LH+A S+GH +C L L +N N+ P +A +NG V+ ++
Sbjct: 922 DENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981
Query: 406 SETEAIAELSCSKDFPSL 423
S + + P+L
Sbjct: 982 SHGATVLAVDEEGHTPAL 999
Score = 38.1 bits (87), Expect = 0.038
Identities = 41/164 (25%), Positives = 70/164 (42%), Gaps = 8/164 (4%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D+ LH AA G LQ L LM +N ++T LTP A + + + +++
Sbjct: 38 DQERRTPLHAAAYVGDVPILQLL--LMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLA 95
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
+ + + K + + +H A K L + SL+ D+ G SA+H A
Sbjct: 96 HSADVN--ARDKLWQTPLHVAAANRATKCAEALAPLLS----SLNVADRSGRSALHHAVH 149
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+L + L+ GA++ + + +P A GH + LV
Sbjct: 150 SGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLV 193
Score = 33.5 bits (75), Expect = 0.94
Identities = 41/162 (25%), Positives = 71/162 (43%), Gaps = 18/162 (11%)
Query: 354 LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAE 413
LH AA+ + + L L + + +N R+ TP +A N +C EA+A
Sbjct: 78 LHRAAASRNEKVLGLLLAHSAD--VNARDKLWQTPLHVAAANRATKCA-------EALAP 128
Query: 414 LSCSKDFP-----SLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHG 468
L S + S +H+A G + + LL +G SL+ D+ +H A+ G
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLLLN----KGASLNVCDKKERQPLHWAAFLG 184
Query: 469 YLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+L ++ LV GA++ ++ G +A G +YL+
Sbjct: 185 HLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLL 226
Score = 31.6 bits (70), Expect = 3.6
Identities = 35/166 (21%), Positives = 70/166 (42%), Gaps = 7/166 (4%)
Query: 347 DENGNNLLHIAASQGHAECLQHLT-SLMGEDCLNER-NTEKLTPAGLAIKNGQLECVRWM 404
D G +H+A++ GH L+ L + + D L+ + +P A G +C+ +
Sbjct: 751 DFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELL 810
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ E + L + P +H A Q+ LL + + ++ D G + +H A
Sbjct: 811 L-EHSPFSYLEGNPFTP--LHCAVINNQDSTTEMLLGALGAKIVN--SRDAKGRTPLHAA 865
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ + ++ L+++ A V +H G +A G T +L+
Sbjct: 866 AFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLL 911
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 59.3 bits (142), Expect = 2e-08
Identities = 51/167 (30%), Positives = 83/167 (49%), Gaps = 11/167 (6%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D+ G+ LH+AA G A + L S +N + TP LA + G + V ++
Sbjct: 460 DDRGHTPLHVAAVCGQASLIDLLVSKGA--MVNATDYHGATPLHLACQKGY-QSVTLLLL 516
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
+A AE+ + L H A YG E + L+ + E LD ++ G++ +H+A++
Sbjct: 517 HYKASAEVQDNNGNTPL-HLACTYGHEDCVKALVYYDVES-CRLDIGNEKGDTPLHIAAR 574
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVE 513
GY G I+TL++ GA+ +QN E P + A L S+ L V+E
Sbjct: 575 WGYQGVIETLLQNGASTEIQNRLKETPLKCA------LNSKILSVME 615
Score = 52.0 bits (123), Expect = 3e-06
Identities = 43/184 (23%), Positives = 85/184 (46%), Gaps = 10/184 (5%)
Query: 345 IHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
+ ++G++ LH+AA G A+ + L L RN ++ P LA + G + V+ +
Sbjct: 739 VTSQDGSSPLHVAALHGRADLIPLL--LKHGANAGARNADQAVPLHLACQQGHFQVVKCL 796
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ + S + P + YA G +++ LLQ G S++ + GN+A+H A
Sbjct: 797 LDSNAKPNKKDLSGNTPLI--YACSGGHHELVALLLQ----HGASINASNNKGNTALHEA 850
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVK 524
++ ++ L+ +GA+V + N AE+ + L VV +C++ V +
Sbjct: 851 VIEKHVFVVELLLLHGASVQVLNKRQRTAVDCAEQNSKIM--ELLQVVPSCVASLDDVAE 908
Query: 525 LTKQ 528
++
Sbjct: 909 TDRK 912
Score = 48.5 bits (114), Expect = 3e-05
Identities = 41/129 (31%), Positives = 60/129 (46%), Gaps = 14/129 (10%)
Query: 381 RNTEKLTPAGLAIKNGQLECVRWMVSETEAI---AELSCSKDFPSLIH----YAGCYGQE 433
R EKL A + +G LE VR+++ TE AE + S P H C +
Sbjct: 668 REVEKLLRA---VADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQ 724
Query: 434 KILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKP 493
K L + G+ ++ QDG+S +HVA+ HG I L+++GAN +N P
Sbjct: 725 K----RLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHGANAGARNADQAVP 780
Query: 494 SQSAERQGH 502
A +QGH
Sbjct: 781 LHLACQQGH 789
Score = 36.2 bits (82), Expect = 0.14
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 344 KIHDENGNNLLHIAASQGHAECLQHLTSLMGEDC-LNERNTEKLTPAGLAIKNG 396
++ D NGN LH+A + GH +C++ L E C L+ N + TP +A + G
Sbjct: 523 EVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWG 576
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 59.3 bits (142), Expect = 2e-08
Identities = 48/165 (29%), Positives = 80/165 (48%), Gaps = 8/165 (4%)
Query: 347 DENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVS 406
D +G LL +AA GH +C++ L L G D +N + T A + G + VR++
Sbjct: 43 DSHGTTLLMVAAYAGHIDCVRELV-LQGAD-INLQRESGTTALFFAAQQGHNDVVRFLFG 100
Query: 407 ETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ 466
A E +KD + + A YG +++ LL+ G ++ + DG +A+ +A+Q
Sbjct: 101 -FGASTEFR-TKDGGTALLAASQYGHMQVVETLLK----HGANIHDQLYDGATALFLAAQ 154
Query: 467 HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV 511
GYL I+ L+ GA V G P A + GH+ R +++
Sbjct: 155 GGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVRVMLL 199
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/158 (24%), Positives = 74/158 (46%), Gaps = 11/158 (6%)
Query: 345 IHDE--NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVR 402
IHD+ +G L +AA G+ + ++ L + + +N+ + P +A + G E VR
Sbjct: 138 IHDQLYDGATALFLAAQGGYLDVIRLLLASGAK--VNQPRQDGTAPLWIASQMGHSEVVR 195
Query: 403 WMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVH 462
M+ + D + + A G ++ LL+F GI ++G SA+H
Sbjct: 196 VML--LRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL-----KNGTSALH 248
Query: 463 VASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQ 500
A G + + L+E GA+ +++N A E P++ + +
Sbjct: 249 AAVLSGNIKTVALLLEAGADPSLRNKANELPAELTKNE 286
Score = 40.8 bits (94), Expect = 0.006
Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 1/74 (1%)
Query: 437 LWLLQFMQEQG-ISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQ 495
L LL+ + G + +D D G + + VA+ G++ C++ LV GA++ +Q +G
Sbjct: 25 LALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRESGTTALF 84
Query: 496 SAERQGHTLCSRYL 509
A +QGH R+L
Sbjct: 85 FAAQQGHNDVVRFL 98
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/155 (28%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
NG LHIAA Q E + L G N + + +TP LA + G E V ++S+
Sbjct: 634 NGYTPLHIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSK- 690
Query: 409 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHG 468
+A L +K + +H G + L++ G+ +D + G + +HVAS +G
Sbjct: 691 QANGNLG-NKSGLTPLHLVAQEGHVPVADVLIK----HGVMVDATTRMGYTPLHVASHYG 745
Query: 469 YLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ ++ L+++ A+V + G P A +QGHT
Sbjct: 746 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 780
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 348 ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
+NG + +H+AA H +C++ L E +++ + LTP +A G + ++ +
Sbjct: 336 KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + P +H A C +K + +++ + + G S+D V + G + +HVAS
Sbjct: 394 GAKPNSRALNGFTP--LHIA-C---KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 447
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+L ++ L++ GA+ + N E P A R GHT ++YL+
Sbjct: 448 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 490
Score = 55.8 bits (133), Expect = 2e-07
Identities = 66/297 (22%), Positives = 119/297 (40%), Gaps = 47/297 (15%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
SLL + + N + + G LH+AA +GHAE + L S L N LTP L
Sbjct: 653 SLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHL 707
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
+ G + ++ + + P +H A YG K++ +LLQ + ++
Sbjct: 708 VAQEGHVPVADVLIKHGVMVDATTRMGYTP--LHVASHYGNIKLVKFLLQHQAD----VN 761
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV 511
+ G S +H A+Q G+ + L++ GA+ + G P A+R G+ + L V
Sbjct: 762 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 821
Query: 512 V--ETC---------MSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLP-- 558
V ET MS V ++ +++ +T+ + +A++ + + +
Sbjct: 822 VTDETSFVLVSDKHRMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEE 881
Query: 559 --------------SSPSSPSSPA---------SRKSQWKSPDADDDSVAKSKPGVQ 592
SP+ P P S + + S + D+DS+ S P +
Sbjct: 882 KELLDFVPKLDQVVESPAIPRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATE 938
Score = 52.0 bits (123), Expect = 3e-06
Identities = 59/235 (25%), Positives = 103/235 (43%), Gaps = 13/235 (5%)
Query: 311 ERSEYLKKVKSI----LNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECL 366
+ ++ LKK+K I L KE + S K + + L A S + L
Sbjct: 3 QAAKQLKKIKDIEAQALQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKAL 62
Query: 367 QHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHY 426
HL + G D +N N L LA K G ++ V ++ + E I E + K +L H
Sbjct: 63 DHLRN--GVD-INTCNQNGLNGLHLASKEGHVKMVVELLHK-EIILETTTKKGNTAL-HI 117
Query: 427 AGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQ 486
A GQ++++ L+ + G +++ Q G + +++A+Q +L ++ L+E GAN +
Sbjct: 118 AALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVA 173
Query: 487 NHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQN 541
G P A +QGH +L+ T + + + + + V LQN
Sbjct: 174 TEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQN 228
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/155 (25%), Positives = 67/155 (43%), Gaps = 10/155 (6%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGE-DCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
NG LHIA + H ++ L D + E LTP +A G L V+ ++
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG---LTPLHVASFMGHLPIVKNLLQR 459
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + + P +H A G ++ +LLQ ++ +D + +H A++
Sbjct: 460 GASPNVSNVKVETP--LHMAARAGHTEVAKYLLQ----NKAKVNAKAKDDQTPLHCAARI 513
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G+ ++ L+E AN + AG P A R+GH
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 27/218 (12%)
Query: 301 LNRTSSQGPEERSEYLKKVKSILNI-VKEGQISLLPHLAA----DNLDKIHDEN------ 349
L+ + G E ++YL + K+ +N K+ Q L H AA N+ K+ EN
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL--HCAARIGHTNMVKLLLENNANPNL 531
Query: 350 ----GNNLLHIAASQGHAE-CLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
G+ LHIAA +GH E L L + C+ ++ TP +A K G++ V +
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG---FTPLHVAAKYGKVR-VAEL 587
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ E +A + K+ + +H A + I+ LL +G S +G + +H+A
Sbjct: 588 LLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLL----PRGGSPHSPAWNGYTPLHIA 642
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
++ + ++L++YG + ++ G P A ++GH
Sbjct: 643 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 680
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/246 (21%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVS--GLNRTSSQGPEERSEYLKKVKSILN 324
H + +TT A H+ + A + + ++ G N + Y+ ++ L
Sbjct: 99 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 158
Query: 325 IVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTE 384
+VK LL + A N + E+G L +A QGH + HL + +
Sbjct: 159 VVK----FLLENGANQN---VATEDGFTPLAVALQQGHENVVAHLINY------GTKGKV 205
Query: 385 KLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQ 444
+L +A +N ++ LS + P +H A Y L + Q +
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP--LHIAAHYEN----LNVAQLLL 259
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
+G S++ Q+G + +H+AS+ G + ++ L++ GA + + P A R GH
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319
Query: 505 CSRYLV 510
S L+
Sbjct: 320 ISEILL 325
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 25/208 (12%)
Query: 319 VKSILNIVKEGQISLLP-HLAADNLDK--------------IHDENGNNLLHIAASQGHA 363
V ++N +G++ L H+AA N D + + G LHIAA H
Sbjct: 193 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HY 249
Query: 364 ECLQHLTSLMGEDC-LNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPS 422
E L L+ +N +TP +A + G + VR ++ I + +KD +
Sbjct: 250 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE--TKTKDELT 307
Query: 423 LIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGAN 482
+H A G +I LL + G + ++G S +H+A+Q +L C++ L++Y A
Sbjct: 308 PLHCAARNGHVRISEILL----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 363
Query: 483 VTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ P A GH ++ L+
Sbjct: 364 IDDITLDHLTPLHVAAHCGHHRVAKVLL 391
Score = 38.9 bits (89), Expect = 0.022
Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 23/227 (10%)
Query: 291 ESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAA--DNLD----- 343
E+K +++++ L+ + G SE L + + + +S + H+AA D+LD
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLL 357
Query: 344 -----KIHDENGNNL--LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNG 396
+I D ++L LH+AA GH + L + N R TP +A K
Sbjct: 358 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP--NSRALNGFTPLHIACKKN 415
Query: 397 QLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQD 456
+ + ++ +I ++ S P +H A G I+ LLQ +S +V+
Sbjct: 416 HVRVMELLLKTGASIDAVTESGLTP--LHVASFMGHLPIVKNLLQRGASPNVSNVKVE-- 471
Query: 457 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ +H+A++ G+ + L++ A V + + P A R GHT
Sbjct: 472 --TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 516
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/155 (28%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
NG LHIAA Q E + L G N + + +TP LA + G E V ++S+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSK- 657
Query: 409 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHG 468
+A L +K + +H G + L++ G+ +D + G + +HVAS +G
Sbjct: 658 QANGNLG-NKSGLTPLHLVAQEGHVPVADVLIK----HGVMVDATTRMGYTPLHVASHYG 712
Query: 469 YLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ ++ L+++ A+V + G P A +QGHT
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 348 ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
+NG + +H+AA H +C++ L E +++ + LTP +A G + ++ +
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + P +H A C +K + +++ + + G S+D V + G + +HVAS
Sbjct: 361 GAKPNSRALNGFTP--LHIA-C---KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+L ++ L++ GA+ + N E P A R GHT ++YL+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 25/230 (10%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
SLL + + N + + G LH+AA +GHAE + L S L N LTP L
Sbjct: 620 SLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHL 674
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
+ G + ++ + + P +H A YG K++ +LLQ + ++
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTP--LHVASHYGNIKLVKFLLQHQAD----VN 728
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV 511
+ G S +H A+Q G+ + L++ GA+ + G P A+R G+ + L V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
Query: 512 V--ETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPS 559
V ET L S R++ + + L+ + EG+ L S
Sbjct: 789 VTDETSFVLVSD------------KHRMSFPETVDEILDVSEDEGEELIS 826
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/190 (25%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 352 NLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAI 411
+ L A S + L HL + G D +N N L LA K G ++ V ++ + E I
Sbjct: 15 SFLRAARSGNLDKALDHLRN--GVD-INTCNQNGLNGLHLASKEGHVKMVVELLHK-EII 70
Query: 412 AELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLG 471
E + K +L H A GQ++++ L+ + G +++ Q G + +++A+Q +L
Sbjct: 71 LETTTKKGNTAL-HIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLE 125
Query: 472 CIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKE 531
++ L+E GAN + G P A +QGH +L+ T + + + + +
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 532 QTVERVTLQN 541
V LQN
Sbjct: 186 TRTAAVLLQN 195
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/155 (25%), Positives = 67/155 (43%), Gaps = 10/155 (6%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGE-DCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
NG LHIA + H ++ L D + E LTP +A G L V+ ++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG---LTPLHVASFMGHLPIVKNLLQR 426
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + + P +H A G ++ +LLQ ++ +D + +H A++
Sbjct: 427 GASPNVSNVKVETP--LHMAARAGHTEVAKYLLQ----NKAKVNAKAKDDQTPLHCAARI 480
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G+ ++ L+E AN + AG P A R+GH
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 27/218 (12%)
Query: 301 LNRTSSQGPEERSEYLKKVKSILNI-VKEGQISLLPHLAA----DNLDKIHDEN------ 349
L+ + G E ++YL + K+ +N K+ Q L H AA N+ K+ EN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL--HCAARIGHTNMVKLLLENNANPNL 498
Query: 350 ----GNNLLHIAASQGHAE-CLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
G+ LHIAA +GH E L L + C+ ++ TP +A K G++ V +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG---FTPLHVAAKYGKVR-VAEL 554
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ E +A + K+ + +H A + I+ LL +G S +G + +H+A
Sbjct: 555 LLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLL----PRGGSPHSPAWNGYTPLHIA 609
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
++ + ++L++YG + ++ G P A ++GH
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/246 (21%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVS--GLNRTSSQGPEERSEYLKKVKSILN 324
H + +TT A H+ + A + + ++ G N + Y+ ++ L
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 325 IVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTE 384
+VK LL + A N + E+G L +A QGH + HL + +
Sbjct: 126 VVK----FLLENGANQN---VATEDGFTPLAVALQQGHENVVAHLINY------GTKGKV 172
Query: 385 KLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQ 444
+L +A +N ++ LS + P +H A Y L + Q +
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP--LHIAAHYEN----LNVAQLLL 226
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
+G S++ Q+G + +H+AS+ G + ++ L++ GA + + P A R GH
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 505 CSRYLV 510
S L+
Sbjct: 287 ISEILL 292
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 25/208 (12%)
Query: 319 VKSILNIVKEGQISLLP-HLAADNLDK--------------IHDENGNNLLHIAASQGHA 363
V ++N +G++ L H+AA N D + + G LHIAA H
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HY 216
Query: 364 ECLQHLTSLMGEDC-LNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPS 422
E L L+ +N +TP +A + G + VR ++ I + +KD +
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE--TKTKDELT 274
Query: 423 LIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGAN 482
+H A G +I LL + G + ++G S +H+A+Q +L C++ L++Y A
Sbjct: 275 PLHCAARNGHVRISEILL----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 483 VTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ P A GH ++ L+
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 38.9 bits (89), Expect = 0.022
Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 23/227 (10%)
Query: 291 ESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAA--DNLD----- 343
E+K +++++ L+ + G SE L + + + +S + H+AA D+LD
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLL 324
Query: 344 -----KIHDENGNNL--LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNG 396
+I D ++L LH+AA GH + L + N R TP +A K
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP--NSRALNGFTPLHIACKKN 382
Query: 397 QLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQD 456
+ + ++ +I ++ S P +H A G I+ LLQ +S +V+
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTP--LHVASFMGHLPIVKNLLQRGASPNVSNVKVE-- 438
Query: 457 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ +H+A++ G+ + L++ A V + + P A R GHT
Sbjct: 439 --TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/155 (28%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
NG LHIAA Q E + L G N + + +TP LA + G E V ++S+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSK- 657
Query: 409 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHG 468
+A L +K + +H G + L++ G+ +D + G + +HVAS +G
Sbjct: 658 QANGNLG-NKSGLTPLHLVAQEGHVPVADVLIK----HGVMVDATTRMGYTPLHVASHYG 712
Query: 469 YLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ ++ L+++ A+V + G P A +QGHT
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 348 ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
+NG + +H+AA H +C++ L E +++ + LTP +A G + ++ +
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + P +H A C +K + +++ + + G S+D V + G + +HVAS
Sbjct: 361 GAKPNSRALNGFTP--LHIA-C---KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+L ++ L++ GA+ + N E P A R GHT ++YL+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 25/230 (10%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
SLL + + N + + G LH+AA +GHAE + L S L N LTP L
Sbjct: 620 SLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHL 674
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
+ G + ++ + + P +H A YG K++ +LLQ + ++
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTP--LHVASHYGNIKLVKFLLQHQAD----VN 728
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV 511
+ G S +H A+Q G+ + L++ GA+ + G P A+R G+ + L V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
Query: 512 V--ETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPS 559
V ET L S R++ + + L+ + EG+ L S
Sbjct: 789 VTDETSFVLVSD------------KHRMSFPETVDEILDVSEDEGEELIS 826
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/190 (25%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 352 NLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAI 411
+ L A S + L HL + G D +N N L LA K G ++ V ++ + E I
Sbjct: 15 SFLRAARSGNLDKALDHLRN--GVD-INTCNQNGLNGLHLASKEGHVKMVVELLHK-EII 70
Query: 412 AELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLG 471
E + K +L H A GQ++++ L+ + G +++ Q G + +++A+Q +L
Sbjct: 71 LETTTKKGNTAL-HIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLE 125
Query: 472 CIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKE 531
++ L+E GAN + G P A +QGH +L+ T + + + + +
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 532 QTVERVTLQN 541
V LQN
Sbjct: 186 TRTAAVLLQN 195
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/155 (25%), Positives = 67/155 (43%), Gaps = 10/155 (6%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGE-DCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
NG LHIA + H ++ L D + E LTP +A G L V+ ++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG---LTPLHVASFMGHLPIVKNLLQR 426
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + + P +H A G ++ +LLQ ++ +D + +H A++
Sbjct: 427 GASPNVSNVKVETP--LHMAARAGHTEVAKYLLQ----NKAKVNAKAKDDQTPLHCAARI 480
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G+ ++ L+E AN + AG P A R+GH
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 27/218 (12%)
Query: 301 LNRTSSQGPEERSEYLKKVKSILNI-VKEGQISLLPHLAA----DNLDKIHDEN------ 349
L+ + G E ++YL + K+ +N K+ Q L H AA N+ K+ EN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL--HCAARIGHTNMVKLLLENNANPNL 498
Query: 350 ----GNNLLHIAASQGHAE-CLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
G+ LHIAA +GH E L L + C+ ++ TP +A K G++ V +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG---FTPLHVAAKYGKVR-VAEL 554
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ E +A + K+ + +H A + I+ LL +G S +G + +H+A
Sbjct: 555 LLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLL----PRGGSPHSPAWNGYTPLHIA 609
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
++ + ++L++YG + ++ G P A ++GH
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/246 (21%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVS--GLNRTSSQGPEERSEYLKKVKSILN 324
H + +TT A H+ + A + + ++ G N + Y+ ++ L
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 325 IVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTE 384
+VK LL + A N + E+G L +A QGH + HL + +
Sbjct: 126 VVK----FLLENGANQN---VATEDGFTPLAVALQQGHENVVAHLINY------GTKGKV 172
Query: 385 KLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQ 444
+L +A +N ++ LS + P +H A Y L + Q +
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP--LHIAAHYEN----LNVAQLLL 226
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
+G S++ Q+G + +H+AS+ G + ++ L++ GA + + P A R GH
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 505 CSRYLV 510
S L+
Sbjct: 287 ISEILL 292
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 25/208 (12%)
Query: 319 VKSILNIVKEGQISLLP-HLAADNLDK--------------IHDENGNNLLHIAASQGHA 363
V ++N +G++ L H+AA N D + + G LHIAA H
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HY 216
Query: 364 ECLQHLTSLMGEDC-LNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPS 422
E L L+ +N +TP +A + G + VR ++ I + +KD +
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE--TKTKDELT 274
Query: 423 LIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGAN 482
+H A G +I LL + G + ++G S +H+A+Q +L C++ L++Y A
Sbjct: 275 PLHCAARNGHVRISEILL----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 483 VTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ P A GH ++ L+
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 38.9 bits (89), Expect = 0.022
Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 23/227 (10%)
Query: 291 ESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAA--DNLD----- 343
E+K +++++ L+ + G SE L + + + +S + H+AA D+LD
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLL 324
Query: 344 -----KIHDENGNNL--LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNG 396
+I D ++L LH+AA GH + L + N R TP +A K
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP--NSRALNGFTPLHIACKKN 382
Query: 397 QLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQD 456
+ + ++ +I ++ S P +H A G I+ LLQ +S +V+
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTP--LHVASFMGHLPIVKNLLQRGASPNVSNVKVE-- 438
Query: 457 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ +H+A++ G+ + L++ A V + + P A R GHT
Sbjct: 439 --TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/155 (28%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
NG LHIAA Q E + L G N + + +TP LA + G E V ++S+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSK- 657
Query: 409 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHG 468
+A L +K + +H G + L++ G+ +D + G + +HVAS +G
Sbjct: 658 QANGNLG-NKSGLTPLHLVAQEGHVPVADVLIK----HGVMVDATTRMGYTPLHVASHYG 712
Query: 469 YLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ ++ L+++ A+V + G P A +QGHT
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 348 ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
+NG + +H+AA H +C++ L E +++ + LTP +A G + ++ +
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + P +H A C +K + +++ + + G S+D V + G + +HVAS
Sbjct: 361 GAKPNSRALNGFTP--LHIA-C---KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+L ++ L++ GA+ + N E P A R GHT ++YL+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 25/230 (10%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
SLL + + N + + G LH+AA +GHAE + L S L N LTP L
Sbjct: 620 SLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHL 674
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
+ G + ++ + + P +H A YG K++ +LLQ + ++
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTP--LHVASHYGNIKLVKFLLQHQAD----VN 728
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV 511
+ G S +H A+Q G+ + L++ GA+ + G P A+R G+ + L V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
Query: 512 V--ETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPS 559
V ET L S R++ + + L+ + EG+ L S
Sbjct: 789 VTDETSFVLVSD------------KHRMSFPETVDEILDVSEDEGEELIS 826
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/190 (25%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 352 NLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAI 411
+ L A S + L HL + G D +N N L LA K G ++ V ++ + E I
Sbjct: 15 SFLRAARSGNLDKALDHLRN--GVD-INTCNQNGLNGLHLASKEGHVKMVVELLHK-EII 70
Query: 412 AELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLG 471
E + K +L H A GQ++++ L+ + G +++ Q G + +++A+Q +L
Sbjct: 71 LETTTKKGNTAL-HIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLE 125
Query: 472 CIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKE 531
++ L+E GAN + G P A +QGH +L+ T + + + + +
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 532 QTVERVTLQN 541
V LQN
Sbjct: 186 TRTAAVLLQN 195
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/155 (25%), Positives = 67/155 (43%), Gaps = 10/155 (6%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGE-DCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
NG LHIA + H ++ L D + E LTP +A G L V+ ++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG---LTPLHVASFMGHLPIVKNLLQR 426
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + + P +H A G ++ +LLQ ++ +D + +H A++
Sbjct: 427 GASPNVSNVKVETP--LHMAARAGHTEVAKYLLQ----NKAKVNAKAKDDQTPLHCAARI 480
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G+ ++ L+E AN + AG P A R+GH
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 27/218 (12%)
Query: 301 LNRTSSQGPEERSEYLKKVKSILNI-VKEGQISLLPHLAA----DNLDKIHDEN------ 349
L+ + G E ++YL + K+ +N K+ Q L H AA N+ K+ EN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL--HCAARIGHTNMVKLLLENNANPNL 498
Query: 350 ----GNNLLHIAASQGHAE-CLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
G+ LHIAA +GH E L L + C+ ++ TP +A K G++ V +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG---FTPLHVAAKYGKVR-VAEL 554
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ E +A + K+ + +H A + I+ LL +G S +G + +H+A
Sbjct: 555 LLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLL----PRGGSPHSPAWNGYTPLHIA 609
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
++ + ++L++YG + ++ G P A ++GH
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/246 (21%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVS--GLNRTSSQGPEERSEYLKKVKSILN 324
H + +TT A H+ + A + + ++ G N + Y+ ++ L
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 325 IVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTE 384
+VK LL + A N + E+G L +A QGH + HL + +
Sbjct: 126 VVK----FLLENGANQN---VATEDGFTPLAVALQQGHENVVAHLINY------GTKGKV 172
Query: 385 KLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQ 444
+L +A +N ++ LS + P +H A Y L + Q +
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP--LHIAAHYEN----LNVAQLLL 226
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
+G S++ Q+G + +H+AS+ G + ++ L++ GA + + P A R GH
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 505 CSRYLV 510
S L+
Sbjct: 287 ISEILL 292
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 25/208 (12%)
Query: 319 VKSILNIVKEGQISLLP-HLAADNLDK--------------IHDENGNNLLHIAASQGHA 363
V ++N +G++ L H+AA N D + + G LHIAA H
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HY 216
Query: 364 ECLQHLTSLMGEDC-LNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPS 422
E L L+ +N +TP +A + G + VR ++ I + +KD +
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE--TKTKDELT 274
Query: 423 LIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGAN 482
+H A G +I LL + G + ++G S +H+A+Q +L C++ L++Y A
Sbjct: 275 PLHCAARNGHVRISEILL----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 483 VTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ P A GH ++ L+
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 38.9 bits (89), Expect = 0.022
Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 23/227 (10%)
Query: 291 ESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAA--DNLD----- 343
E+K +++++ L+ + G SE L + + + +S + H+AA D+LD
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLL 324
Query: 344 -----KIHDENGNNL--LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNG 396
+I D ++L LH+AA GH + L + N R TP +A K
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP--NSRALNGFTPLHIACKKN 382
Query: 397 QLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQD 456
+ + ++ +I ++ S P +H A G I+ LLQ +S +V+
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTP--LHVASFMGHLPIVKNLLQRGASPNVSNVKVE-- 438
Query: 457 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ +H+A++ G+ + L++ A V + + P A R GHT
Sbjct: 439 --TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/155 (28%), Positives = 74/155 (47%), Gaps = 8/155 (5%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSET 408
NG LHIAA Q E + L G N + + +TP LA + G E V ++S+
Sbjct: 601 NGYTPLHIAAKQNQVEVARSLLQYGGS--ANAESVQGVTPLHLAAQEGHAEMVALLLSK- 657
Query: 409 EAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHG 468
+A L +K + +H G + L++ G+ +D + G + +HVAS +G
Sbjct: 658 QANGNLG-NKSGLTPLHLVAQEGHVPVADVLIK----HGVMVDATTRMGYTPLHVASHYG 712
Query: 469 YLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ ++ L+++ A+V + G P A +QGHT
Sbjct: 713 NIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHT 747
Score = 58.5 bits (140), Expect = 3e-08
Identities = 43/163 (26%), Positives = 83/163 (50%), Gaps = 8/163 (4%)
Query: 348 ENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
+NG + +H+AA H +C++ L E +++ + LTP +A G + ++ +
Sbjct: 303 KNGLSPIHMAAQGDHLDCVRLLLQYDAE--IDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + P +H A C +K + +++ + + G S+D V + G + +HVAS
Sbjct: 361 GAKPNSRALNGFTP--LHIA-C---KKNHVRVMELLLKTGASIDAVTESGLTPLHVASFM 414
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLV 510
G+L ++ L++ GA+ + N E P A R GHT ++YL+
Sbjct: 415 GHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLL 457
Score = 56.2 bits (134), Expect = 1e-07
Identities = 58/230 (25%), Positives = 97/230 (42%), Gaps = 25/230 (10%)
Query: 332 SLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGL 391
SLL + + N + + G LH+AA +GHAE + L S L N LTP L
Sbjct: 620 SLLQYGGSANAESVQ---GVTPLHLAAQEGHAEMVALLLSKQANGNLG--NKSGLTPLHL 674
Query: 392 AIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLD 451
+ G + ++ + + P +H A YG K++ +LLQ + ++
Sbjct: 675 VAQEGHVPVADVLIKHGVMVDATTRMGYTP--LHVASHYGNIKLVKFLLQHQAD----VN 728
Query: 452 EVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVV 511
+ G S +H A+Q G+ + L++ GA+ + G P A+R G+ + L V
Sbjct: 729 AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKV 788
Query: 512 V--ETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPS 559
V ET L S R++ + + L+ + EG+ L S
Sbjct: 789 VTDETSFVLVSD------------KHRMSFPETVDEILDVSEDEGEELIS 826
Score = 50.1 bits (118), Expect = 1e-05
Identities = 49/190 (25%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 352 NLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAI 411
+ L A S + L HL + G D +N N L LA K G ++ V ++ + E I
Sbjct: 15 SFLRAARSGNLDKALDHLRN--GVD-INTCNQNGLNGLHLASKEGHVKMVVELLHK-EII 70
Query: 412 AELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLG 471
E + K +L H A GQ++++ L+ + G +++ Q G + +++A+Q +L
Sbjct: 71 LETTTKKGNTAL-HIAALAGQDEVVRELVNY----GANVNAQSQKGFTPLYMAAQENHLE 125
Query: 472 CIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKE 531
++ L+E GAN + G P A +QGH +L+ T + + + + +
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDD 185
Query: 532 QTVERVTLQN 541
V LQN
Sbjct: 186 TRTAAVLLQN 195
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/155 (25%), Positives = 67/155 (43%), Gaps = 10/155 (6%)
Query: 349 NGNNLLHIAASQGHAECLQHLTSLMGE-DCLNERNTEKLTPAGLAIKNGQLECVRWMVSE 407
NG LHIA + H ++ L D + E LTP +A G L V+ ++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG---LTPLHVASFMGHLPIVKNLLQR 426
Query: 408 TEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQH 467
+ + + P +H A G ++ +LLQ ++ +D + +H A++
Sbjct: 427 GASPNVSNVKVETP--LHMAARAGHTEVAKYLLQ----NKAKVNAKAKDDQTPLHCAARI 480
Query: 468 GYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
G+ ++ L+E AN + AG P A R+GH
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 27/218 (12%)
Query: 301 LNRTSSQGPEERSEYLKKVKSILNI-VKEGQISLLPHLAA----DNLDKIHDEN------ 349
L+ + G E ++YL + K+ +N K+ Q L H AA N+ K+ EN
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL--HCAARIGHTNMVKLLLENNANPNL 498
Query: 350 ----GNNLLHIAASQGHAE-CLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWM 404
G+ LHIAA +GH E L L + C+ ++ TP +A K G++ V +
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKG---FTPLHVAAKYGKVR-VAEL 554
Query: 405 VSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVA 464
+ E +A + K+ + +H A + I+ LL +G S +G + +H+A
Sbjct: 555 LLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLL----PRGGSPHSPAWNGYTPLHIA 609
Query: 465 SQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGH 502
++ + ++L++YG + ++ G P A ++GH
Sbjct: 610 AKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGH 647
Score = 44.3 bits (103), Expect = 5e-04
Identities = 54/246 (21%), Positives = 99/246 (40%), Gaps = 21/246 (8%)
Query: 267 HGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVS--GLNRTSSQGPEERSEYLKKVKSILN 324
H + +TT A H+ + A + + ++ G N + Y+ ++ L
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 325 IVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTE 384
+VK LL + A N + E+G L +A QGH + HL + +
Sbjct: 126 VVK----FLLENGANQN---VATEDGFTPLAVALQQGHENVVAHLINY------GTKGKV 172
Query: 385 KLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQ 444
+L +A +N ++ LS + P +H A Y L + Q +
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTP--LHIAAHYEN----LNVAQLLL 226
Query: 445 EQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTL 504
+G S++ Q+G + +H+AS+ G + ++ L++ GA + + P A R GH
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 505 CSRYLV 510
S L+
Sbjct: 287 ISEILL 292
Score = 42.7 bits (99), Expect = 0.002
Identities = 51/208 (24%), Positives = 88/208 (42%), Gaps = 25/208 (12%)
Query: 319 VKSILNIVKEGQISLLP-HLAADNLDK--------------IHDENGNNLLHIAASQGHA 363
V ++N +G++ L H+AA N D + + G LHIAA H
Sbjct: 160 VAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAA---HY 216
Query: 364 ECLQHLTSLMGEDC-LNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPS 422
E L L+ +N +TP +A + G + VR ++ I + +KD +
Sbjct: 217 ENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE--TKTKDELT 274
Query: 423 LIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGAN 482
+H A G +I LL + G + ++G S +H+A+Q +L C++ L++Y A
Sbjct: 275 PLHCAARNGHVRISEILL----DHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAE 330
Query: 483 VTMQNHAGEKPSQSAERQGHTLCSRYLV 510
+ P A GH ++ L+
Sbjct: 331 IDDITLDHLTPLHVAAHCGHHRVAKVLL 358
Score = 38.9 bits (89), Expect = 0.022
Identities = 54/227 (23%), Positives = 99/227 (43%), Gaps = 23/227 (10%)
Query: 291 ESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAA--DNLD----- 343
E+K +++++ L+ + G SE L + + + +S + H+AA D+LD
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLL 324
Query: 344 -----KIHDENGNNL--LHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNG 396
+I D ++L LH+AA GH + L + N R TP +A K
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP--NSRALNGFTPLHIACKKN 382
Query: 397 QLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQD 456
+ + ++ +I ++ S P +H A G I+ LLQ +S +V+
Sbjct: 383 HVRVMELLLKTGASIDAVTESGLTP--LHVASFMGHLPIVKNLLQRGASPNVSNVKVE-- 438
Query: 457 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHT 503
+ +H+A++ G+ + L++ A V + + P A R GHT
Sbjct: 439 --TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHT 483
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.346
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,622,904
Number of Sequences: 37866
Number of extensions: 1873275
Number of successful extensions: 12782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 252
Number of HSP's successfully gapped in prelim test: 415
Number of HSP's that attempted gapping in prelim test: 10202
Number of HSP's gapped (non-prelim): 2364
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.