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Search of human proteins with 75750529
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75750529 ankyrin repeat and MYND domain containing 1 isoform
1 [Homo sapiens]
(941 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75750529 ankyrin repeat and MYND domain containing 1 isoform ... 1943 0.0
gi|75750531 ankyrin repeat and MYND domain containing 1 isoform ... 926 0.0
gi|18254456 testis-specific gene A2 [Homo sapiens] 65 3e-10
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 62 3e-09
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 60 1e-08
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 60 1e-08
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 60 1e-08
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 60 1e-08
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 60 1e-08
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 59 2e-08
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 59 2e-08
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 59 2e-08
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 57 6e-08
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 57 6e-08
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 57 6e-08
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 57 8e-08
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 56 2e-07
gi|13376267 MORN repeat containing 1 [Homo sapiens] 54 5e-07
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 53 1e-06
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 52 2e-06
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 52 3e-06
gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [H... 51 6e-06
gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens] 50 8e-06
gi|149999376 MORN repeat containing 4 [Homo sapiens] 50 8e-06
gi|30520314 MORN repeat containing 4 [Homo sapiens] 50 8e-06
gi|157502187 radial spoke head 10 homolog B [Homo sapiens] 50 8e-06
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 50 1e-05
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 49 3e-05
gi|224282170 MORN repeat containing 2 [Homo sapiens] 47 6e-05
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 47 6e-05
>gi|75750529 ankyrin repeat and MYND domain containing 1 isoform 1
[Homo sapiens]
Length = 941
Score = 1943 bits (5033), Expect = 0.0
Identities = 941/941 (100%), Positives = 941/941 (100%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY
Sbjct: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
Query: 61 GTMYMKTRLFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQIPSGFSLLRYPE 120
GTMYMKTRLFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQIPSGFSLLRYPE
Sbjct: 61 GTMYMKTRLFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQIPSGFSLLRYPE 120
Query: 121 FSSFITHSPARISLSEEEKTEWGLQEGQDPFFYDYKRFLLNDNLTLPPEMYVYSTNSDHL 180
FSSFITHSPARISLSEEEKTEWGLQEGQDPFFYDYKRFLLNDNLTLPPEMYVYSTNSDHL
Sbjct: 121 FSSFITHSPARISLSEEEKTEWGLQEGQDPFFYDYKRFLLNDNLTLPPEMYVYSTNSDHL 180
Query: 181 PMTSSFRKELDARIFLNEIPPFVEDGEPWFIINETPLLVKIQKQTYKFRNKPAHTSWNMG 240
PMTSSFRKELDARIFLNEIPPFVEDGEPWFIINETPLLVKIQKQTYKFRNKPAHTSWNMG
Sbjct: 181 PMTSSFRKELDARIFLNEIPPFVEDGEPWFIINETPLLVKIQKQTYKFRNKPAHTSWNMG 240
Query: 241 AILEGKRSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAA 300
AILEGKRSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAA
Sbjct: 241 AILEGKRSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAA 300
Query: 301 ATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPK 360
ATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPK
Sbjct: 301 ATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPK 360
Query: 361 FPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQC 420
FPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQC
Sbjct: 361 FPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQC 420
Query: 421 GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIE 480
GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIE
Sbjct: 421 GGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIE 480
Query: 481 LSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADP 540
LSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADP
Sbjct: 481 LSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADP 540
Query: 541 NLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQI 600
NLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQI
Sbjct: 541 NLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQI 600
Query: 601 VELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT 660
VELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT
Sbjct: 601 VELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT 660
Query: 661 ALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELLTQGAD 720
ALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELLTQGAD
Sbjct: 661 ALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELLTQGAD 720
Query: 721 PNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQGEKEAVGT 780
PNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQGEKEAVGT
Sbjct: 721 PNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQGEKEAVGT 780
Query: 781 AVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKESQWDPTW 840
AVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKESQWDPTW
Sbjct: 781 AVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKESQWDPTW 840
Query: 841 LYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLPCPRCYGI 900
LYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLPCPRCYGI
Sbjct: 841 LYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLPCPRCYGI 900
Query: 901 LTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 941
LTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ
Sbjct: 901 LTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 941
>gi|75750531 ankyrin repeat and MYND domain containing 1 isoform 2
[Homo sapiens]
Length = 717
Score = 926 bits (2393), Expect = 0.0
Identities = 493/648 (76%), Positives = 508/648 (78%), Gaps = 99/648 (15%)
Query: 302 THCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKF 361
THCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKF
Sbjct: 161 THCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKF 220
Query: 362 PVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCG 421
PVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCG
Sbjct: 221 PVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCG 280
Query: 422 GSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIEL 481
GSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIEL
Sbjct: 281 GSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIEL 340
Query: 482 SQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPN 541
SQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTI
Sbjct: 341 SQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTI----------- 389
Query: 542 LCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIV 601
+LLL GA ++C P + L +A +GV++
Sbjct: 390 ---------------------KLLLRRGADPNLCCVP----MQVLFLAVKAGDVDGVRL- 423
Query: 602 ELLLH-AITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT 660
LL H A TD+ + P L P + ALP E G
Sbjct: 424 -LLEHGARTDI---------CFPPQLSTLTPLHIA---------------AALPGEEGV- 457
Query: 661 ALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNE-------LVVKE 713
IV LLL H+ + + +E VVKE
Sbjct: 458 ----------------QIVELLL------------HAITDVDAKASDEDDTYKPGKVVKE 489
Query: 714 LLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQG 773
LLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQG
Sbjct: 490 LLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPVMLRQG 549
Query: 774 EKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKE 833
EKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKE
Sbjct: 550 EKEAVGTAVDYGYFRFFQDRRIARCPFHTLMPAERETFLARKRLLEYMGLQLRQAVFAKE 609
Query: 834 SQWDPTWLYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLP 893
SQWDPTWLYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLP
Sbjct: 610 SQWDPTWLYLCKRAELIPSHRMKKKGPSLPRGLDVKEQGQIPFFKFCYQCGRSIGVRLLP 669
Query: 894 CPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 941
CPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ
Sbjct: 670 CPRCYGILTCSKYCKTKAWTEFHKKDCGDLVAIVTQLEQVSRRREEFQ 717
Score = 164 bits (414), Expect = 5e-40
Identities = 71/71 (100%), Positives = 71/71 (100%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY
Sbjct: 90 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 149
Query: 61 GTMYMKTRLFQ 71
GTMYMKTRLFQ
Sbjct: 150 GTMYMKTRLFQ 160
>gi|18254456 testis-specific gene A2 [Homo sapiens]
Length = 309
Score = 65.1 bits (157), Expect = 3e-10
Identities = 34/102 (33%), Positives = 53/102 (51%), Gaps = 2/102 (1%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Y+G + + G G + + G Y G++ R+ HG GT+++PDGS + G + R G+G
Sbjct: 44 YEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHG 103
Query: 62 T-MYMKTRLFQGLYKADQRFGPGVETYPD-GSQDVGLWFREQ 101
Y+ + G + A QR G G Y + GS+ VG W Q
Sbjct: 104 VYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQ 145
Score = 53.1 bits (126), Expect = 1e-06
Identities = 25/95 (26%), Positives = 49/95 (51%), Gaps = 1/95 (1%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPD-GSSFTGTFYLSHREGY 60
Y+GE+ +++ G+G + + ++Y G+++ HG GTY++ + GS + GT+ +EG
Sbjct: 90 YEGEWANDLRHGHGVYYYINNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGT 149
Query: 61 GTMYMKTRLFQGLYKADQRFGPGVETYPDGSQDVG 95
+ +QG + GPG + G + G
Sbjct: 150 AELIHLNHRYQGKFLNKNPVGPGKYVFDVGCEQHG 184
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/90 (30%), Positives = 43/90 (47%), Gaps = 1/90 (1%)
Query: 13 GYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGT-MYMKTRLFQ 71
G G+ P G++Y G + HG G Y + +G+ + G + + + G GT +Y ++
Sbjct: 32 GRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYE 91
Query: 72 GLYKADQRFGPGVETYPDGSQDVGLWFREQ 101
G + D R G GV Y + G WF Q
Sbjct: 92 GEWANDLRHGHGVYYYINNDTYTGEWFAHQ 121
Score = 42.0 bits (97), Expect = 0.003
Identities = 24/77 (31%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 22 GESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKT-RLFQGLYKADQRF 80
GE G+ HG G P+G ++ G++ R G G K + G Y +++
Sbjct: 18 GEYEGGRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKH 77
Query: 81 GPGVETYPDGSQDVGLW 97
G G YPDGS+ G W
Sbjct: 78 GQGTFIYPDGSRYEGEW 94
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 62.0 bits (149), Expect = 3e-09
Identities = 126/499 (25%), Positives = 202/499 (40%), Gaps = 87/499 (17%)
Query: 270 GNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTA 329
G HE I L + A + AD +G T L AAA H +IV LLD GA+VN +G TA
Sbjct: 654 GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTA 713
Query: 330 LSMCFLLHYPAQSFKPNVAERTI---PEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVP 386
LS+ L PA +V I E K + P+L +
Sbjct: 714 LSVAALC-VPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVA----------------- 755
Query: 387 SQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLV-KGSLGHV 445
+YE LLL EG G +DH ++ G +PL+ S+GH
Sbjct: 756 ---AYEGHVDVVDLLL-------EG---------GADVDHTDNN--GRTPLLAAASMGHA 794
Query: 446 ESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMASPSPCT 505
S + +L +E + ++ ++E+ + +L+R + A +P
Sbjct: 795 -SVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENH-RDDAGWTPLH 852
Query: 506 SSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQVLFLAVKAGDVDGVRLL 565
+ +G R + ++IE+ R I G P LA + G D V++L
Sbjct: 853 MAAFEG-HRLICEALIEQGARTNEID---NDGRIP---------FILASQEGHYDCVQIL 899
Query: 566 LEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPG 625
LE+ + D + L AAL G IVELL DV+ K +D T
Sbjct: 900 LENKSNIDQRGYDGRNALR----VAALEGHR--DIVELLFSHGADVNCKDADGRPTLYIL 953
Query: 626 KLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSH 685
L+ + + E G + + GRTALH++C + ++V++L+++
Sbjct: 954 ALENQLTMAEYFLENG-------ANVEASDAEGRTALHVSCWQGH-----MEMVQVLIAY 1001
Query: 686 GANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQ 744
A+ N + S L + G+ VV+ L+ GA + +G +ALC+A
Sbjct: 1002 HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQG-ATALCIAA------- 1053
Query: 745 RNMDSKLALIDRLISHGAD 763
+ + ++ L+ HGAD
Sbjct: 1054 --QEGHIDVVQVLLEHGAD 1070
Score = 45.8 bits (107), Expect = 2e-04
Identities = 21/56 (37%), Positives = 31/56 (55%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ +L A ++ DA G+T L AA H +VN L+ CGA++N +G TAL
Sbjct: 560 VVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTAL 615
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/72 (36%), Positives = 35/72 (48%)
Query: 259 LSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGAD 318
LS+ + H + +L D A D D G T L AA H D+V+LLL+ GAD
Sbjct: 714 LSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773
Query: 319 VNKCSDEGLTAL 330
V+ + G T L
Sbjct: 774 VDHTDNNGRTPL 785
Score = 41.6 bits (96), Expect = 0.004
Identities = 63/230 (27%), Positives = 99/230 (43%), Gaps = 55/230 (23%)
Query: 549 VLFLAVKAGDVDGVRLLLEHGA----RTDICFPPQLSTLTPLHIAAALPGEEGVQIVELL 604
VL +A G+V+ VR LL+ G R D + TPLH+AA EG + L+
Sbjct: 817 VLSIASAQGNVEVVRTLLDRGLDENHRDDAGW-------TPLHMAAF----EGHR---LI 862
Query: 605 LHAITDVDAKASDEDDTYKPGKLDLLPSS---------LKLSNEPGPPQAYYSTDTALPE 655
A+ + A+ ++ D+ G++ + +S + L N+ Q Y
Sbjct: 863 CEALIEQGARTNEIDND---GRIPFILASQEGHYDCVQILLENKSNIDQRGYD------- 912
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKE-L 714
GR AL +A RDIV LL SHGA+ N + P +A N+L + E
Sbjct: 913 --GRNALRVAALEGH-----RDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYF 965
Query: 715 LTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
L GA+ +G +AL V+C + ++ LI++ AD+
Sbjct: 966 LENGANVEASDAEG-RTALHVSC---------WQGHMEMVQVLIAYHADV 1005
Score = 41.2 bits (95), Expect = 0.005
Identities = 27/70 (38%), Positives = 37/70 (52%), Gaps = 1/70 (1%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKC 322
+++ A EG H + +L + A D D G T L AAA+ H +VN LL GA V+
Sbjct: 752 LLVAAYEG-HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 323 SDEGLTALSM 332
EG T LS+
Sbjct: 811 DSEGRTVLSI 820
Score = 40.8 bits (94), Expect = 0.006
Identities = 25/61 (40%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Query: 264 ILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCS 323
IL ++EG+++ + +IL +N ++ D G L AA H DIV LL GADVN C
Sbjct: 885 ILASQEGHYDCV-QILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN-CK 942
Query: 324 D 324
D
Sbjct: 943 D 943
Score = 40.4 bits (93), Expect = 0.008
Identities = 33/96 (34%), Positives = 46/96 (47%), Gaps = 20/96 (20%)
Query: 255 PKEQLSMEMILKAEEGNH------------------EWICRILKDNFASADVADAKGYTV 296
PKEQ +++++KA G H E R L DN AS + D+ G T+
Sbjct: 491 PKEQEVLQLLVKA--GAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTL 548
Query: 297 LAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 332
LA AA D+VNLL+ GAD+ G T L++
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 584
Score = 39.3 bits (90), Expect = 0.017
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 264 ILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAA-----THCHNDIVNLLLDCGAD 318
++ A H I L D+ A + D G T L+ AA + H +V+LL+D GA+
Sbjct: 681 LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE 740
Query: 319 VNKCSDEGLTAL 330
V+ C +G+T L
Sbjct: 741 VDHCDKDGMTPL 752
Score = 37.7 bits (86), Expect = 0.051
Identities = 24/69 (34%), Positives = 34/69 (49%)
Query: 264 ILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCS 323
+L A H + L A+ D D++G TVL+ A+ + ++V LLD G D N
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 324 DEGLTALSM 332
D G T L M
Sbjct: 845 DAGWTPLHM 853
Score = 36.6 bits (83), Expect = 0.11
Identities = 21/59 (35%), Positives = 31/59 (52%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
H + ++L ++ A D +G T L AA H D+V +LL+ GAD N G TA+
Sbjct: 1024 HVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAM 1082
Score = 32.0 bits (71), Expect = 2.8
Identities = 19/47 (40%), Positives = 30/47 (63%), Gaps = 1/47 (2%)
Query: 677 DIVRLLLSHGANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPN 722
D+V LL+S GA+ + + GH+PL+L+ G+ VV L+ GA+ N
Sbjct: 559 DVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN 605
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 60.1 bits (144), Expect = 1e-08
Identities = 109/490 (22%), Positives = 192/490 (39%), Gaps = 82/490 (16%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ R L + A+ + KG+T L AA H ++V LL+ GA+ N +++G T L++
Sbjct: 126 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 185
Query: 335 LLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELR 394
Q + VA + + P + I + + DT ++ + +
Sbjct: 186 -----QQGHENVVAHLINYGTKGKVRLPALHIAARN-DDTRTAAVLLQND---------- 229
Query: 395 PPPAPLLLPRVSGSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESG 448
P P L + H H+++ G S++ + G +PL H+ S
Sbjct: 230 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASR 281
Query: 449 LEDVLG---NTDRGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMA-SP 501
+V+ DRG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 282 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 341
Query: 502 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVD 560
+ M + ++LLL+ A+ ++ + L +A G
Sbjct: 342 ----------------IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 385
Query: 561 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
++LL+ GA+ + L+ TPLHIA + V+++ELLL +DA
Sbjct: 386 VAKVLLDKGAKPN---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLT 439
Query: 621 TYK----PGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT--ALHMACEREDDNKC 674
G L ++ + L+ P T + G T A ++ + N
Sbjct: 440 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
Query: 675 ARD---------------IVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQG 718
A+D +V+LLL + ANPNL +GH+PL ++ G+ V LL +
Sbjct: 500 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 559
Query: 719 ADPNLPLTKG 728
A KG
Sbjct: 560 ASQACMTKKG 569
Score = 59.7 bits (143), Expect = 1e-08
Identities = 76/258 (29%), Positives = 115/258 (44%), Gaps = 28/258 (10%)
Query: 510 KGTMRRMALSMIERRKRWRTIKLLLRRGADPN-LCCVPMQVLFLAVKAGDVDGVRLLLEH 568
KG +R AL + R RT +LL+ +P+ L L +A +++ +LLL
Sbjct: 202 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261
Query: 569 GARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE-DDTYKPGKL 627
GA + F PQ + +TPLHIA+ V +V LLL ++ K DE + +
Sbjct: 262 GASVN--FTPQ-NGITPLHIASR---RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 315
Query: 628 DLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGA 687
+ S L + P QA + G + +HMA + + D VRLLL + A
Sbjct: 316 GHVRISEILLDHGAPIQA--------KTKNGLSPIHMAAQGDH-----LDCVRLLLQYDA 362
Query: 688 NPNLLWSGH-SPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRN 746
+ + H +PL ++ G+ V K LL +GA PN G + L +AC H R
Sbjct: 363 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-TPLHIAC--KKNHVRV 419
Query: 747 MDSKL---ALIDRLISHG 761
M+ L A ID + G
Sbjct: 420 MELLLKTGASIDAVTESG 437
Score = 59.3 bits (142), Expect = 2e-08
Identities = 112/489 (22%), Positives = 185/489 (37%), Gaps = 78/489 (15%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + ++L D A + G+T L A H ++ LLL GA ++ ++ GLT L
Sbjct: 383 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 442
Query: 332 MC-FLLHYP------AQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVN 384
+ F+ H P + PNV+ + P L + + E Y +
Sbjct: 443 VASFMGHLPIVKNLLQRGASPNVSNVKVETP-----------LHMAARAGHTEVAKYLLQ 491
Query: 385 VPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS----SSLKGDSPL-VK 439
++ + + + PL H T +++ + ++ G +PL +
Sbjct: 492 NKAKVNAKAKDDQTPL--------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543
Query: 440 GSLGHVESGLEDVLGNTDRGSLCSAETKFES-NVCVCDFSIELSQAMLERSAQSHSLLKM 498
GHVE+ L L + C + F +V + +++ +LER A ++
Sbjct: 544 AREGHVETVL--ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---- 597
Query: 499 ASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL-CCVPMQVLFLAVKAG 557
G L + +KLLL RG P+ L +A K
Sbjct: 598 -----------AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 646
Query: 558 DVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 617
V+ R LL++G + + +TPLH+AA E ++V LLL S
Sbjct: 647 QVEVARSLLQYGGSAN---AESVQGVTPLHLAAQ---EGHAEMVALLL----------SK 690
Query: 618 EDDTYKPGKLDLLPSSLKLSNEPGPPQA----YYSTDTALPEEGGRTALHMACEREDDNK 673
+ + K L P L ++ E P A + G T LH+A +
Sbjct: 691 QANGNLGNKSGLTPLHL-VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK- 748
Query: 674 CARDIVRLLLSHGANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSA 732
+V+ LL H A+ N G+SPL + G+ +V LL GA PN + G +
Sbjct: 749 ----LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TP 803
Query: 733 LCVACDLTY 741
L +A L Y
Sbjct: 804 LAIAKRLGY 812
Score = 52.8 bits (125), Expect = 2e-06
Identities = 131/543 (24%), Positives = 212/543 (39%), Gaps = 94/543 (17%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L + AS + G T L A+ + +V LLLD GA + + + LT L
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL---- 309
Query: 335 LLHYPAQSFKPNVAERTIPEP---QEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSY 391
H A++ ++E + Q K + PI ++ D +L+ V + Q
Sbjct: 310 --HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD-HLDC----VRLLLQYDA 362
Query: 392 ELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL-VKGSLGHVESGLE 450
E+ L P +H G H S +L G +PL + HV +
Sbjct: 363 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR--VM 420
Query: 451 DVLGNTDRGSLCSAETKFESNVC---VCDFS--IELSQAMLERSAQSH-SLLKMASPSPC 504
++L T S + ES + V F + + + +L+R A + S +K+ +P
Sbjct: 421 ELLLKTG----ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP--- 473
Query: 505 TSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVR 563
L M R K LL+ A N Q L A + G + V+
Sbjct: 474 -------------LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
Query: 564 LLLEHGARTDICFPPQLSTL---TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
LLLE+ A P L+T TPLHIAA EG VE +L + ++A
Sbjct: 521 LLLENNAN------PNLATTAGHTPLHIAA----REGH--VETVLALLEKEASQACMTKK 568
Query: 621 TYKP-------GKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNK 673
+ P GK+ + + L L + P A + G T LH+A +
Sbjct: 569 GFTPLHVAAKYGKVRV--AELLLERDAHPNAA---------GKNGLTPLHVAVHHNN--- 614
Query: 674 CARDIVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGL--- 729
DIV+LLL G +P+ W+G++PL ++ V + LL G N +G+
Sbjct: 615 --LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 672
Query: 730 ------GSALCVACDLTYEHQRNMDSKLAL--IDRLISHGADILKPVMLRQGEKEAVGTA 781
G A VA L+ + N+ +K L + + G + V+++ G T
Sbjct: 673 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 732
Query: 782 VDY 784
+ Y
Sbjct: 733 MGY 735
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 45/222 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L++A + ++ V+ LLE+GA ++ TPL +A G E V V L++ T
Sbjct: 148 LYMAAQENHLEVVKFLLENGANQNVATE---DGFTPLAVALQ-QGHENV--VAHLINYGT 201
Query: 610 DVDAK------ASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALH 663
+ A+ DDT +++ L N+P P + + G T LH
Sbjct: 202 KGKVRLPALHIAARNDDT--------RTAAVLLQNDPNPD---------VLSKTGFTPLH 244
Query: 664 MACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPN 722
+A E+ N + +LLL+ GA+ N +G +PL ++ GN ++V+ LL +GA
Sbjct: 245 IAAHYENLN-----VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 299
Query: 723 LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
L C A RN +++ I L+ HGA I
Sbjct: 300 TKTKDELTPLHCAA--------RNGHVRISEI--LLDHGAPI 331
Score = 33.9 bits (76), Expect = 0.73
Identities = 22/77 (28%), Positives = 36/77 (46%)
Query: 254 GPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLL 313
G K ++ + + A + +L N + DV G+T L AA + + ++ LLL
Sbjct: 200 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 259
Query: 314 DCGADVNKCSDEGLTAL 330
+ GA VN G+T L
Sbjct: 260 NRGASVNFTPQNGITPL 276
Score = 33.1 bits (74), Expect = 1.2
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELL 715
+ G LH+A + + +V LL G++ L ++ +G + VV+EL+
Sbjct: 76 QNGLNGLHLASKEGH----VKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 131
Query: 716 TQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGA-------DILKP- 767
GA+ N KG T + ++ L ++ L+ +GA D P
Sbjct: 132 NYGANVNAQSQKG----------FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 181
Query: 768 -VMLRQGEKEAVGTAVDYG 785
V L+QG + V ++YG
Sbjct: 182 AVALQQGHENVVAHLINYG 200
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG+ E + +L+ AS KG+T L AA + + LLL+ A N
Sbjct: 542 IAAREGHVETVLALLEKE-ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 600
Query: 325 EGLTAL 330
GLT L
Sbjct: 601 NGLTPL 606
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N + R L SA+ +G T L AA H ++V LLL A+ N + G
Sbjct: 642 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 701
Query: 327 LTALSM 332
LT L +
Sbjct: 702 LTPLHL 707
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 60.1 bits (144), Expect = 1e-08
Identities = 109/490 (22%), Positives = 192/490 (39%), Gaps = 82/490 (16%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ R L + A+ + KG+T L AA H ++V LL+ GA+ N +++G T L++
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 335 LLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELR 394
Q + VA + + P + I + + DT ++ + +
Sbjct: 153 -----QQGHENVVAHLINYGTKGKVRLPALHIAARN-DDTRTAAVLLQND---------- 196
Query: 395 PPPAPLLLPRVSGSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESG 448
P P L + H H+++ G S++ + G +PL H+ S
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASR 248
Query: 449 LEDVLG---NTDRGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMA-SP 501
+V+ DRG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 502 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVD 560
+ M + ++LLL+ A+ ++ + L +A G
Sbjct: 309 ----------------IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 561 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
++LL+ GA+ + L+ TPLHIA + V+++ELLL +DA
Sbjct: 353 VAKVLLDKGAKPN---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 621 TYK----PGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT--ALHMACEREDDNKC 674
G L ++ + L+ P T + G T A ++ + N
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 675 ARD---------------IVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQG 718
A+D +V+LLL + ANPNL +GH+PL ++ G+ V LL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 719 ADPNLPLTKG 728
A KG
Sbjct: 527 ASQACMTKKG 536
Score = 59.7 bits (143), Expect = 1e-08
Identities = 76/258 (29%), Positives = 115/258 (44%), Gaps = 28/258 (10%)
Query: 510 KGTMRRMALSMIERRKRWRTIKLLLRRGADPN-LCCVPMQVLFLAVKAGDVDGVRLLLEH 568
KG +R AL + R RT +LL+ +P+ L L +A +++ +LLL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 569 GARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE-DDTYKPGKL 627
GA + F PQ + +TPLHIA+ V +V LLL ++ K DE + +
Sbjct: 229 GASVN--FTPQ-NGITPLHIASR---RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 628 DLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGA 687
+ S L + P QA + G + +HMA + + D VRLLL + A
Sbjct: 283 GHVRISEILLDHGAPIQA--------KTKNGLSPIHMAAQGDH-----LDCVRLLLQYDA 329
Query: 688 NPNLLWSGH-SPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRN 746
+ + H +PL ++ G+ V K LL +GA PN G + L +AC H R
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-TPLHIAC--KKNHVRV 386
Query: 747 MDSKL---ALIDRLISHG 761
M+ L A ID + G
Sbjct: 387 MELLLKTGASIDAVTESG 404
Score = 59.3 bits (142), Expect = 2e-08
Identities = 112/489 (22%), Positives = 185/489 (37%), Gaps = 78/489 (15%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + ++L D A + G+T L A H ++ LLL GA ++ ++ GLT L
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 332 MC-FLLHYP------AQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVN 384
+ F+ H P + PNV+ + P L + + E Y +
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETP-----------LHMAARAGHTEVAKYLLQ 458
Query: 385 VPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS----SSLKGDSPL-VK 439
++ + + + PL H T +++ + ++ G +PL +
Sbjct: 459 NKAKVNAKAKDDQTPL--------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 440 GSLGHVESGLEDVLGNTDRGSLCSAETKFES-NVCVCDFSIELSQAMLERSAQSHSLLKM 498
GHVE+ L L + C + F +V + +++ +LER A ++
Sbjct: 511 AREGHVETVL--ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---- 564
Query: 499 ASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL-CCVPMQVLFLAVKAG 557
G L + +KLLL RG P+ L +A K
Sbjct: 565 -----------AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 558 DVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 617
V+ R LL++G + + +TPLH+AA E ++V LLL S
Sbjct: 614 QVEVARSLLQYGGSAN---AESVQGVTPLHLAAQ---EGHAEMVALLL----------SK 657
Query: 618 EDDTYKPGKLDLLPSSLKLSNEPGPPQA----YYSTDTALPEEGGRTALHMACEREDDNK 673
+ + K L P L ++ E P A + G T LH+A +
Sbjct: 658 QANGNLGNKSGLTPLHL-VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK- 715
Query: 674 CARDIVRLLLSHGANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSA 732
+V+ LL H A+ N G+SPL + G+ +V LL GA PN + G +
Sbjct: 716 ----LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TP 770
Query: 733 LCVACDLTY 741
L +A L Y
Sbjct: 771 LAIAKRLGY 779
Score = 52.8 bits (125), Expect = 2e-06
Identities = 131/543 (24%), Positives = 212/543 (39%), Gaps = 94/543 (17%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L + AS + G T L A+ + +V LLLD GA + + + LT L
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL---- 276
Query: 335 LLHYPAQSFKPNVAERTIPEP---QEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSY 391
H A++ ++E + Q K + PI ++ D +L+ V + Q
Sbjct: 277 --HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD-HLDC----VRLLLQYDA 329
Query: 392 ELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL-VKGSLGHVESGLE 450
E+ L P +H G H S +L G +PL + HV +
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR--VM 387
Query: 451 DVLGNTDRGSLCSAETKFESNVC---VCDFS--IELSQAMLERSAQSH-SLLKMASPSPC 504
++L T S + ES + V F + + + +L+R A + S +K+ +P
Sbjct: 388 ELLLKTG----ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP--- 440
Query: 505 TSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVR 563
L M R K LL+ A N Q L A + G + V+
Sbjct: 441 -------------LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 564 LLLEHGARTDICFPPQLSTL---TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
LLLE+ A P L+T TPLHIAA EG VE +L + ++A
Sbjct: 488 LLLENNAN------PNLATTAGHTPLHIAA----REGH--VETVLALLEKEASQACMTKK 535
Query: 621 TYKP-------GKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNK 673
+ P GK+ + + L L + P A + G T LH+A +
Sbjct: 536 GFTPLHVAAKYGKVRV--AELLLERDAHPNAA---------GKNGLTPLHVAVHHNN--- 581
Query: 674 CARDIVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGL--- 729
DIV+LLL G +P+ W+G++PL ++ V + LL G N +G+
Sbjct: 582 --LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Query: 730 ------GSALCVACDLTYEHQRNMDSKLAL--IDRLISHGADILKPVMLRQGEKEAVGTA 781
G A VA L+ + N+ +K L + + G + V+++ G T
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
Query: 782 VDY 784
+ Y
Sbjct: 700 MGY 702
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 45/222 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L++A + ++ V+ LLE+GA ++ TPL +A G E V V L++ T
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATE---DGFTPLAVALQ-QGHENV--VAHLINYGT 168
Query: 610 DVDAK------ASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALH 663
+ A+ DDT +++ L N+P P + + G T LH
Sbjct: 169 KGKVRLPALHIAARNDDT--------RTAAVLLQNDPNPD---------VLSKTGFTPLH 211
Query: 664 MACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPN 722
+A E+ N + +LLL+ GA+ N +G +PL ++ GN ++V+ LL +GA
Sbjct: 212 IAAHYENLN-----VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 723 LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
L C A RN +++ I L+ HGA I
Sbjct: 267 TKTKDELTPLHCAA--------RNGHVRISEI--LLDHGAPI 298
Score = 33.9 bits (76), Expect = 0.73
Identities = 22/77 (28%), Positives = 36/77 (46%)
Query: 254 GPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLL 313
G K ++ + + A + +L N + DV G+T L AA + + ++ LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 314 DCGADVNKCSDEGLTAL 330
+ GA VN G+T L
Sbjct: 227 NRGASVNFTPQNGITPL 243
Score = 33.1 bits (74), Expect = 1.2
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELL 715
+ G LH+A + + +V LL G++ L ++ +G + VV+EL+
Sbjct: 43 QNGLNGLHLASKEGH----VKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 716 TQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGA-------DILKP- 767
GA+ N KG T + ++ L ++ L+ +GA D P
Sbjct: 99 NYGANVNAQSQKG----------FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 768 -VMLRQGEKEAVGTAVDYG 785
V L+QG + V ++YG
Sbjct: 149 AVALQQGHENVVAHLINYG 167
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG+ E + +L+ AS KG+T L AA + + LLL+ A N
Sbjct: 509 IAAREGHVETVLALLEKE-ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 325 EGLTAL 330
GLT L
Sbjct: 568 NGLTPL 573
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N + R L SA+ +G T L AA H ++V LLL A+ N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 327 LTALSM 332
LT L +
Sbjct: 669 LTPLHL 674
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 60.1 bits (144), Expect = 1e-08
Identities = 109/490 (22%), Positives = 192/490 (39%), Gaps = 82/490 (16%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ R L + A+ + KG+T L AA H ++V LL+ GA+ N +++G T L++
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 335 LLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELR 394
Q + VA + + P + I + + DT ++ + +
Sbjct: 153 -----QQGHENVVAHLINYGTKGKVRLPALHIAARN-DDTRTAAVLLQND---------- 196
Query: 395 PPPAPLLLPRVSGSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESG 448
P P L + H H+++ G S++ + G +PL H+ S
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASR 248
Query: 449 LEDVLG---NTDRGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMA-SP 501
+V+ DRG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 502 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVD 560
+ M + ++LLL+ A+ ++ + L +A G
Sbjct: 309 ----------------IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 561 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
++LL+ GA+ + L+ TPLHIA + V+++ELLL +DA
Sbjct: 353 VAKVLLDKGAKPN---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 621 TYK----PGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT--ALHMACEREDDNKC 674
G L ++ + L+ P T + G T A ++ + N
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 675 ARD---------------IVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQG 718
A+D +V+LLL + ANPNL +GH+PL ++ G+ V LL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 719 ADPNLPLTKG 728
A KG
Sbjct: 527 ASQACMTKKG 536
Score = 59.7 bits (143), Expect = 1e-08
Identities = 76/258 (29%), Positives = 115/258 (44%), Gaps = 28/258 (10%)
Query: 510 KGTMRRMALSMIERRKRWRTIKLLLRRGADPN-LCCVPMQVLFLAVKAGDVDGVRLLLEH 568
KG +R AL + R RT +LL+ +P+ L L +A +++ +LLL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 569 GARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE-DDTYKPGKL 627
GA + F PQ + +TPLHIA+ V +V LLL ++ K DE + +
Sbjct: 229 GASVN--FTPQ-NGITPLHIASR---RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 628 DLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGA 687
+ S L + P QA + G + +HMA + + D VRLLL + A
Sbjct: 283 GHVRISEILLDHGAPIQA--------KTKNGLSPIHMAAQGDH-----LDCVRLLLQYDA 329
Query: 688 NPNLLWSGH-SPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRN 746
+ + H +PL ++ G+ V K LL +GA PN G + L +AC H R
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-TPLHIAC--KKNHVRV 386
Query: 747 MDSKL---ALIDRLISHG 761
M+ L A ID + G
Sbjct: 387 MELLLKTGASIDAVTESG 404
Score = 59.3 bits (142), Expect = 2e-08
Identities = 112/489 (22%), Positives = 185/489 (37%), Gaps = 78/489 (15%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + ++L D A + G+T L A H ++ LLL GA ++ ++ GLT L
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 332 MC-FLLHYP------AQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVN 384
+ F+ H P + PNV+ + P L + + E Y +
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETP-----------LHMAARAGHTEVAKYLLQ 458
Query: 385 VPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS----SSLKGDSPL-VK 439
++ + + + PL H T +++ + ++ G +PL +
Sbjct: 459 NKAKVNAKAKDDQTPL--------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 440 GSLGHVESGLEDVLGNTDRGSLCSAETKFES-NVCVCDFSIELSQAMLERSAQSHSLLKM 498
GHVE+ L L + C + F +V + +++ +LER A ++
Sbjct: 511 AREGHVETVL--ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---- 564
Query: 499 ASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL-CCVPMQVLFLAVKAG 557
G L + +KLLL RG P+ L +A K
Sbjct: 565 -----------AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 558 DVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 617
V+ R LL++G + + +TPLH+AA E ++V LLL S
Sbjct: 614 QVEVARSLLQYGGSAN---AESVQGVTPLHLAAQ---EGHAEMVALLL----------SK 657
Query: 618 EDDTYKPGKLDLLPSSLKLSNEPGPPQA----YYSTDTALPEEGGRTALHMACEREDDNK 673
+ + K L P L ++ E P A + G T LH+A +
Sbjct: 658 QANGNLGNKSGLTPLHL-VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK- 715
Query: 674 CARDIVRLLLSHGANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSA 732
+V+ LL H A+ N G+SPL + G+ +V LL GA PN + G +
Sbjct: 716 ----LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TP 770
Query: 733 LCVACDLTY 741
L +A L Y
Sbjct: 771 LAIAKRLGY 779
Score = 52.8 bits (125), Expect = 2e-06
Identities = 131/543 (24%), Positives = 212/543 (39%), Gaps = 94/543 (17%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L + AS + G T L A+ + +V LLLD GA + + + LT L
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL---- 276
Query: 335 LLHYPAQSFKPNVAERTIPEP---QEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSY 391
H A++ ++E + Q K + PI ++ D +L+ V + Q
Sbjct: 277 --HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD-HLDC----VRLLLQYDA 329
Query: 392 ELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL-VKGSLGHVESGLE 450
E+ L P +H G H S +L G +PL + HV +
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR--VM 387
Query: 451 DVLGNTDRGSLCSAETKFESNVC---VCDFS--IELSQAMLERSAQSH-SLLKMASPSPC 504
++L T S + ES + V F + + + +L+R A + S +K+ +P
Sbjct: 388 ELLLKTG----ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP--- 440
Query: 505 TSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVR 563
L M R K LL+ A N Q L A + G + V+
Sbjct: 441 -------------LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 564 LLLEHGARTDICFPPQLSTL---TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
LLLE+ A P L+T TPLHIAA EG VE +L + ++A
Sbjct: 488 LLLENNAN------PNLATTAGHTPLHIAA----REGH--VETVLALLEKEASQACMTKK 535
Query: 621 TYKP-------GKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNK 673
+ P GK+ + + L L + P A + G T LH+A +
Sbjct: 536 GFTPLHVAAKYGKVRV--AELLLERDAHPNAA---------GKNGLTPLHVAVHHNN--- 581
Query: 674 CARDIVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGL--- 729
DIV+LLL G +P+ W+G++PL ++ V + LL G N +G+
Sbjct: 582 --LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Query: 730 ------GSALCVACDLTYEHQRNMDSKLAL--IDRLISHGADILKPVMLRQGEKEAVGTA 781
G A VA L+ + N+ +K L + + G + V+++ G T
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
Query: 782 VDY 784
+ Y
Sbjct: 700 MGY 702
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 45/222 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L++A + ++ V+ LLE+GA ++ TPL +A G E V V L++ T
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATE---DGFTPLAVALQ-QGHENV--VAHLINYGT 168
Query: 610 DVDAK------ASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALH 663
+ A+ DDT +++ L N+P P + + G T LH
Sbjct: 169 KGKVRLPALHIAARNDDT--------RTAAVLLQNDPNPD---------VLSKTGFTPLH 211
Query: 664 MACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPN 722
+A E+ N + +LLL+ GA+ N +G +PL ++ GN ++V+ LL +GA
Sbjct: 212 IAAHYENLN-----VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 723 LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
L C A RN +++ I L+ HGA I
Sbjct: 267 TKTKDELTPLHCAA--------RNGHVRISEI--LLDHGAPI 298
Score = 33.9 bits (76), Expect = 0.73
Identities = 22/77 (28%), Positives = 36/77 (46%)
Query: 254 GPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLL 313
G K ++ + + A + +L N + DV G+T L AA + + ++ LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 314 DCGADVNKCSDEGLTAL 330
+ GA VN G+T L
Sbjct: 227 NRGASVNFTPQNGITPL 243
Score = 33.1 bits (74), Expect = 1.2
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELL 715
+ G LH+A + + +V LL G++ L ++ +G + VV+EL+
Sbjct: 43 QNGLNGLHLASKEGH----VKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 716 TQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGA-------DILKP- 767
GA+ N KG T + ++ L ++ L+ +GA D P
Sbjct: 99 NYGANVNAQSQKG----------FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 768 -VMLRQGEKEAVGTAVDYG 785
V L+QG + V ++YG
Sbjct: 149 AVALQQGHENVVAHLINYG 167
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG+ E + +L+ AS KG+T L AA + + LLL+ A N
Sbjct: 509 IAAREGHVETVLALLEKE-ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 325 EGLTAL 330
GLT L
Sbjct: 568 NGLTPL 573
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N + R L SA+ +G T L AA H ++V LLL A+ N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 327 LTALSM 332
LT L +
Sbjct: 669 LTPLHL 674
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 60.1 bits (144), Expect = 1e-08
Identities = 109/490 (22%), Positives = 192/490 (39%), Gaps = 82/490 (16%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ R L + A+ + KG+T L AA H ++V LL+ GA+ N +++G T L++
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 335 LLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELR 394
Q + VA + + P + I + + DT ++ + +
Sbjct: 153 -----QQGHENVVAHLINYGTKGKVRLPALHIAARN-DDTRTAAVLLQND---------- 196
Query: 395 PPPAPLLLPRVSGSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESG 448
P P L + H H+++ G S++ + G +PL H+ S
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASR 248
Query: 449 LEDVLG---NTDRGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMA-SP 501
+V+ DRG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 502 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVD 560
+ M + ++LLL+ A+ ++ + L +A G
Sbjct: 309 ----------------IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 561 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
++LL+ GA+ + L+ TPLHIA + V+++ELLL +DA
Sbjct: 353 VAKVLLDKGAKPN---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 621 TYK----PGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT--ALHMACEREDDNKC 674
G L ++ + L+ P T + G T A ++ + N
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 675 ARD---------------IVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQG 718
A+D +V+LLL + ANPNL +GH+PL ++ G+ V LL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 719 ADPNLPLTKG 728
A KG
Sbjct: 527 ASQACMTKKG 536
Score = 59.7 bits (143), Expect = 1e-08
Identities = 76/258 (29%), Positives = 115/258 (44%), Gaps = 28/258 (10%)
Query: 510 KGTMRRMALSMIERRKRWRTIKLLLRRGADPN-LCCVPMQVLFLAVKAGDVDGVRLLLEH 568
KG +R AL + R RT +LL+ +P+ L L +A +++ +LLL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 569 GARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE-DDTYKPGKL 627
GA + F PQ + +TPLHIA+ V +V LLL ++ K DE + +
Sbjct: 229 GASVN--FTPQ-NGITPLHIASR---RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 628 DLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGA 687
+ S L + P QA + G + +HMA + + D VRLLL + A
Sbjct: 283 GHVRISEILLDHGAPIQA--------KTKNGLSPIHMAAQGDH-----LDCVRLLLQYDA 329
Query: 688 NPNLLWSGH-SPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRN 746
+ + H +PL ++ G+ V K LL +GA PN G + L +AC H R
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-TPLHIAC--KKNHVRV 386
Query: 747 MDSKL---ALIDRLISHG 761
M+ L A ID + G
Sbjct: 387 MELLLKTGASIDAVTESG 404
Score = 59.3 bits (142), Expect = 2e-08
Identities = 112/489 (22%), Positives = 185/489 (37%), Gaps = 78/489 (15%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + ++L D A + G+T L A H ++ LLL GA ++ ++ GLT L
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 332 MC-FLLHYP------AQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVN 384
+ F+ H P + PNV+ + P L + + E Y +
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETP-----------LHMAARAGHTEVAKYLLQ 458
Query: 385 VPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS----SSLKGDSPL-VK 439
++ + + + PL H T +++ + ++ G +PL +
Sbjct: 459 NKAKVNAKAKDDQTPL--------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 440 GSLGHVESGLEDVLGNTDRGSLCSAETKFES-NVCVCDFSIELSQAMLERSAQSHSLLKM 498
GHVE+ L L + C + F +V + +++ +LER A ++
Sbjct: 511 AREGHVETVL--ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---- 564
Query: 499 ASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL-CCVPMQVLFLAVKAG 557
G L + +KLLL RG P+ L +A K
Sbjct: 565 -----------AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 558 DVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 617
V+ R LL++G + + +TPLH+AA E ++V LLL S
Sbjct: 614 QVEVARSLLQYGGSAN---AESVQGVTPLHLAAQ---EGHAEMVALLL----------SK 657
Query: 618 EDDTYKPGKLDLLPSSLKLSNEPGPPQA----YYSTDTALPEEGGRTALHMACEREDDNK 673
+ + K L P L ++ E P A + G T LH+A +
Sbjct: 658 QANGNLGNKSGLTPLHL-VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK- 715
Query: 674 CARDIVRLLLSHGANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSA 732
+V+ LL H A+ N G+SPL + G+ +V LL GA PN + G +
Sbjct: 716 ----LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TP 770
Query: 733 LCVACDLTY 741
L +A L Y
Sbjct: 771 LAIAKRLGY 779
Score = 52.8 bits (125), Expect = 2e-06
Identities = 131/543 (24%), Positives = 212/543 (39%), Gaps = 94/543 (17%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L + AS + G T L A+ + +V LLLD GA + + + LT L
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL---- 276
Query: 335 LLHYPAQSFKPNVAERTIPEP---QEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSY 391
H A++ ++E + Q K + PI ++ D +L+ V + Q
Sbjct: 277 --HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD-HLDC----VRLLLQYDA 329
Query: 392 ELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL-VKGSLGHVESGLE 450
E+ L P +H G H S +L G +PL + HV +
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR--VM 387
Query: 451 DVLGNTDRGSLCSAETKFESNVC---VCDFS--IELSQAMLERSAQSH-SLLKMASPSPC 504
++L T S + ES + V F + + + +L+R A + S +K+ +P
Sbjct: 388 ELLLKTG----ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP--- 440
Query: 505 TSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVR 563
L M R K LL+ A N Q L A + G + V+
Sbjct: 441 -------------LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 564 LLLEHGARTDICFPPQLSTL---TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
LLLE+ A P L+T TPLHIAA EG VE +L + ++A
Sbjct: 488 LLLENNAN------PNLATTAGHTPLHIAA----REGH--VETVLALLEKEASQACMTKK 535
Query: 621 TYKP-------GKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNK 673
+ P GK+ + + L L + P A + G T LH+A +
Sbjct: 536 GFTPLHVAAKYGKVRV--AELLLERDAHPNAA---------GKNGLTPLHVAVHHNN--- 581
Query: 674 CARDIVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGL--- 729
DIV+LLL G +P+ W+G++PL ++ V + LL G N +G+
Sbjct: 582 --LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Query: 730 ------GSALCVACDLTYEHQRNMDSKLAL--IDRLISHGADILKPVMLRQGEKEAVGTA 781
G A VA L+ + N+ +K L + + G + V+++ G T
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
Query: 782 VDY 784
+ Y
Sbjct: 700 MGY 702
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 45/222 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L++A + ++ V+ LLE+GA ++ TPL +A G E V V L++ T
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATE---DGFTPLAVALQ-QGHENV--VAHLINYGT 168
Query: 610 DVDAK------ASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALH 663
+ A+ DDT +++ L N+P P + + G T LH
Sbjct: 169 KGKVRLPALHIAARNDDT--------RTAAVLLQNDPNPD---------VLSKTGFTPLH 211
Query: 664 MACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPN 722
+A E+ N + +LLL+ GA+ N +G +PL ++ GN ++V+ LL +GA
Sbjct: 212 IAAHYENLN-----VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 723 LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
L C A RN +++ I L+ HGA I
Sbjct: 267 TKTKDELTPLHCAA--------RNGHVRISEI--LLDHGAPI 298
Score = 33.9 bits (76), Expect = 0.73
Identities = 22/77 (28%), Positives = 36/77 (46%)
Query: 254 GPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLL 313
G K ++ + + A + +L N + DV G+T L AA + + ++ LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 314 DCGADVNKCSDEGLTAL 330
+ GA VN G+T L
Sbjct: 227 NRGASVNFTPQNGITPL 243
Score = 33.1 bits (74), Expect = 1.2
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELL 715
+ G LH+A + + +V LL G++ L ++ +G + VV+EL+
Sbjct: 43 QNGLNGLHLASKEGH----VKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 716 TQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGA-------DILKP- 767
GA+ N KG T + ++ L ++ L+ +GA D P
Sbjct: 99 NYGANVNAQSQKG----------FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 768 -VMLRQGEKEAVGTAVDYG 785
V L+QG + V ++YG
Sbjct: 149 AVALQQGHENVVAHLINYG 167
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG+ E + +L+ AS KG+T L AA + + LLL+ A N
Sbjct: 509 IAAREGHVETVLALLEKE-ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 325 EGLTAL 330
GLT L
Sbjct: 568 NGLTPL 573
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N + R L SA+ +G T L AA H ++V LLL A+ N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 327 LTALSM 332
LT L +
Sbjct: 669 LTPLHL 674
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 60.1 bits (144), Expect = 1e-08
Identities = 109/490 (22%), Positives = 192/490 (39%), Gaps = 82/490 (16%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ R L + A+ + KG+T L AA H ++V LL+ GA+ N +++G T L++
Sbjct: 93 VVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVAL 152
Query: 335 LLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELR 394
Q + VA + + P + I + + DT ++ + +
Sbjct: 153 -----QQGHENVVAHLINYGTKGKVRLPALHIAARN-DDTRTAAVLLQND---------- 196
Query: 395 PPPAPLLLPRVSGSHEGGHFQDTGQC------GGSIDHRSSSLKGDSPLVKGSLGHVESG 448
P P L + H H+++ G S++ + G +PL H+ S
Sbjct: 197 PNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN--GITPL------HIASR 248
Query: 449 LEDVLG---NTDRGSLCSAETKFESNVCVC---DFSIELSQAMLERSAQSHSLLKMA-SP 501
+V+ DRG+ +TK E C + + +S+ +L+ A + K SP
Sbjct: 249 RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 308
Query: 502 SPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGAD-PNLCCVPMQVLFLAVKAGDVD 560
+ M + ++LLL+ A+ ++ + L +A G
Sbjct: 309 ----------------IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHR 352
Query: 561 GVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
++LL+ GA+ + L+ TPLHIA + V+++ELLL +DA
Sbjct: 353 VAKVLLDKGAKPN---SRALNGFTPLHIACK---KNHVRVMELLLKTGASIDAVTESGLT 406
Query: 621 TYK----PGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRT--ALHMACEREDDNKC 674
G L ++ + L+ P T + G T A ++ + N
Sbjct: 407 PLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 675 ARD---------------IVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQG 718
A+D +V+LLL + ANPNL +GH+PL ++ G+ V LL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 719 ADPNLPLTKG 728
A KG
Sbjct: 527 ASQACMTKKG 536
Score = 59.7 bits (143), Expect = 1e-08
Identities = 76/258 (29%), Positives = 115/258 (44%), Gaps = 28/258 (10%)
Query: 510 KGTMRRMALSMIERRKRWRTIKLLLRRGADPN-LCCVPMQVLFLAVKAGDVDGVRLLLEH 568
KG +R AL + R RT +LL+ +P+ L L +A +++ +LLL
Sbjct: 169 KGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228
Query: 569 GARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE-DDTYKPGKL 627
GA + F PQ + +TPLHIA+ V +V LLL ++ K DE + +
Sbjct: 229 GASVN--FTPQ-NGITPLHIASR---RGNVIMVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 628 DLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGA 687
+ S L + P QA + G + +HMA + + D VRLLL + A
Sbjct: 283 GHVRISEILLDHGAPIQA--------KTKNGLSPIHMAAQGDH-----LDCVRLLLQYDA 329
Query: 688 NPNLLWSGH-SPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRN 746
+ + H +PL ++ G+ V K LL +GA PN G + L +AC H R
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGF-TPLHIAC--KKNHVRV 386
Query: 747 MDSKL---ALIDRLISHG 761
M+ L A ID + G
Sbjct: 387 MELLLKTGASIDAVTESG 404
Score = 59.3 bits (142), Expect = 2e-08
Identities = 112/489 (22%), Positives = 185/489 (37%), Gaps = 78/489 (15%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + ++L D A + G+T L A H ++ LLL GA ++ ++ GLT L
Sbjct: 350 HHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLH 409
Query: 332 MC-FLLHYP------AQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVN 384
+ F+ H P + PNV+ + P L + + E Y +
Sbjct: 410 VASFMGHLPIVKNLLQRGASPNVSNVKVETP-----------LHMAARAGHTEVAKYLLQ 458
Query: 385 VPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS----SSLKGDSPL-VK 439
++ + + + PL H T +++ + ++ G +PL +
Sbjct: 459 NKAKVNAKAKDDQTPL--------HCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Query: 440 GSLGHVESGLEDVLGNTDRGSLCSAETKFES-NVCVCDFSIELSQAMLERSAQSHSLLKM 498
GHVE+ L L + C + F +V + +++ +LER A ++
Sbjct: 511 AREGHVETVL--ALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNA---- 564
Query: 499 ASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL-CCVPMQVLFLAVKAG 557
G L + +KLLL RG P+ L +A K
Sbjct: 565 -----------AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 558 DVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASD 617
V+ R LL++G + + +TPLH+AA E ++V LLL S
Sbjct: 614 QVEVARSLLQYGGSAN---AESVQGVTPLHLAAQ---EGHAEMVALLL----------SK 657
Query: 618 EDDTYKPGKLDLLPSSLKLSNEPGPPQA----YYSTDTALPEEGGRTALHMACEREDDNK 673
+ + K L P L ++ E P A + G T LH+A +
Sbjct: 658 QANGNLGNKSGLTPLHL-VAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK- 715
Query: 674 CARDIVRLLLSHGANPNLLWS-GHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSA 732
+V+ LL H A+ N G+SPL + G+ +V LL GA PN + G +
Sbjct: 716 ----LVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT-TP 770
Query: 733 LCVACDLTY 741
L +A L Y
Sbjct: 771 LAIAKRLGY 779
Score = 52.8 bits (125), Expect = 2e-06
Identities = 131/543 (24%), Positives = 212/543 (39%), Gaps = 94/543 (17%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L + AS + G T L A+ + +V LLLD GA + + + LT L
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPL---- 276
Query: 335 LLHYPAQSFKPNVAERTIPEP---QEPPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSY 391
H A++ ++E + Q K + PI ++ D +L+ V + Q
Sbjct: 277 --HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD-HLDC----VRLLLQYDA 329
Query: 392 ELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL-VKGSLGHVESGLE 450
E+ L P +H G H S +L G +PL + HV +
Sbjct: 330 EIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVR--VM 387
Query: 451 DVLGNTDRGSLCSAETKFESNVC---VCDFS--IELSQAMLERSAQSH-SLLKMASPSPC 504
++L T S + ES + V F + + + +L+R A + S +K+ +P
Sbjct: 388 ELLLKTG----ASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETP--- 440
Query: 505 TSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVR 563
L M R K LL+ A N Q L A + G + V+
Sbjct: 441 -------------LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 564 LLLEHGARTDICFPPQLSTL---TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDD 620
LLLE+ A P L+T TPLHIAA EG VE +L + ++A
Sbjct: 488 LLLENNAN------PNLATTAGHTPLHIAA----REGH--VETVLALLEKEASQACMTKK 535
Query: 621 TYKP-------GKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNK 673
+ P GK+ + + L L + P A + G T LH+A +
Sbjct: 536 GFTPLHVAAKYGKVRV--AELLLERDAHPNAA---------GKNGLTPLHVAVHHNN--- 581
Query: 674 CARDIVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGL--- 729
DIV+LLL G +P+ W+G++PL ++ V + LL G N +G+
Sbjct: 582 --LDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPL 639
Query: 730 ------GSALCVACDLTYEHQRNMDSKLAL--IDRLISHGADILKPVMLRQGEKEAVGTA 781
G A VA L+ + N+ +K L + + G + V+++ G T
Sbjct: 640 HLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTR 699
Query: 782 VDY 784
+ Y
Sbjct: 700 MGY 702
Score = 45.4 bits (106), Expect = 2e-04
Identities = 60/222 (27%), Positives = 98/222 (44%), Gaps = 45/222 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L++A + ++ V+ LLE+GA ++ TPL +A G E V V L++ T
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATE---DGFTPLAVALQ-QGHENV--VAHLINYGT 168
Query: 610 DVDAK------ASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALH 663
+ A+ DDT +++ L N+P P + + G T LH
Sbjct: 169 KGKVRLPALHIAARNDDT--------RTAAVLLQNDPNPD---------VLSKTGFTPLH 211
Query: 664 MACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPN 722
+A E+ N + +LLL+ GA+ N +G +PL ++ GN ++V+ LL +GA
Sbjct: 212 IAAHYENLN-----VAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIE 266
Query: 723 LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
L C A RN +++ I L+ HGA I
Sbjct: 267 TKTKDELTPLHCAA--------RNGHVRISEI--LLDHGAPI 298
Score = 33.9 bits (76), Expect = 0.73
Identities = 22/77 (28%), Positives = 36/77 (46%)
Query: 254 GPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLL 313
G K ++ + + A + +L N + DV G+T L AA + + ++ LLL
Sbjct: 167 GTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 314 DCGADVNKCSDEGLTAL 330
+ GA VN G+T L
Sbjct: 227 NRGASVNFTPQNGITPL 243
Score = 33.1 bits (74), Expect = 1.2
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELL 715
+ G LH+A + + +V LL G++ L ++ +G + VV+EL+
Sbjct: 43 QNGLNGLHLASKEGH----VKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELV 98
Query: 716 TQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGA-------DILKP- 767
GA+ N KG T + ++ L ++ L+ +GA D P
Sbjct: 99 NYGANVNAQSQKG----------FTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPL 148
Query: 768 -VMLRQGEKEAVGTAVDYG 785
V L+QG + V ++YG
Sbjct: 149 AVALQQGHENVVAHLINYG 167
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%), Gaps = 1/66 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG+ E + +L+ AS KG+T L AA + + LLL+ A N
Sbjct: 509 IAAREGHVETVLALLEKE-ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK 567
Query: 325 EGLTAL 330
GLT L
Sbjct: 568 NGLTPL 573
Score = 30.8 bits (68), Expect = 6.2
Identities = 22/66 (33%), Positives = 31/66 (46%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N + R L SA+ +G T L AA H ++V LLL A+ N + G
Sbjct: 609 AAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSG 668
Query: 327 LTALSM 332
LT L +
Sbjct: 669 LTPLHL 674
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 58.9 bits (141), Expect = 2e-08
Identities = 75/285 (26%), Positives = 117/285 (41%), Gaps = 62/285 (21%)
Query: 530 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 588
+ LLL+ GA P++ + + L +A +AG V+ VR LL +GA D TPLHI
Sbjct: 426 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD---ARAREEQTPLHI 482
Query: 589 AAALPGEEGVQIVELLLHAITDVDAKASDE----DDTYKPGKLDLLPSSLK------LSN 638
A+ L E IV+LLL + DA ++ + + G++D+ L+ L+
Sbjct: 483 ASRLGKTE---IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 539
Query: 639 EPG-----PPQAYYSTDTA-----------LPEEGGRTALHMACEREDDNKCARDIVRLL 682
+ G Y S D A + G T LH+A ++ + + LL
Sbjct: 540 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN-----QKVALLL 594
Query: 683 LSHGANPN-LLWSGHSPLSLSIASGNELVVKELLTQGADPN------------------- 722
L GA+P+ +G++PL ++ + LL GA+ N
Sbjct: 595 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 654
Query: 723 ----LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGAD 763
L L KG + LT H + K+ + D L HGAD
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 699
Score = 57.0 bits (136), Expect = 8e-08
Identities = 117/498 (23%), Positives = 192/498 (38%), Gaps = 90/498 (18%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L A+ + G+T L AA H D+V LL+ GA+ + +++G T L++
Sbjct: 91 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 150
Query: 335 -----------------------LLHYPAQSFKPNVAERTIPEPQE---PPKFPVVPILS 368
LH A+ A + K V
Sbjct: 151 QQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 210
Query: 369 SSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS 428
S F ++ + Y VNV A LLL R G D G
Sbjct: 211 SGFTPLHIAAHYGNVNV------------ATLLLNR-------GAAVDFTARNGITPLHV 251
Query: 429 SSLKGDSPLVKGSL---GHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAM 485
+S +G++ +VK L G +++ D L C+A + + V + +E +
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH----CAARSGHDQ---VVELLLERGAPL 304
Query: 486 LERSAQSHSLLKMASPS---PCT-------SSFDKGTMRRM-ALSMIERRKRWRTIKLLL 534
L R+ S L MA+ C + D T+ + AL + +R KLLL
Sbjct: 305 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 364
Query: 535 RRGADPNLCCV-PMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALP 593
+ A+PN + L +A K + + LL+++GA S LTP+H+AA +
Sbjct: 365 DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE---SGLTPIHVAAFM- 420
Query: 594 GEEGVQIVELLLHAITDVDAKASDE--DDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDT 651
G + ++ L A DV + + G+++++ L+ D
Sbjct: 421 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG---------ALVDA 471
Query: 652 ALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPN-LLWSGHSPLSLSIASGNELV 710
EE +T LH+A +IV+LLL H A+P+ +G++PL +S G V
Sbjct: 472 RAREE--QTPLHIA-----SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 524
Query: 711 VKELLTQGADPNLPLTKG 728
LL GA +L KG
Sbjct: 525 ASVLLEAGAAHSLATKKG 542
Score = 47.4 bits (111), Expect = 6e-05
Identities = 68/267 (25%), Positives = 112/267 (41%), Gaps = 38/267 (14%)
Query: 478 SIELSQAMLERSAQSHSLLKMA-SPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRR 536
S+++++ +L+R A + S K +P + +D +++AL LLL +
Sbjct: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN---QKVAL-------------LLLEK 597
Query: 537 GADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGE 595
GA P+ L +A K + LL +GA T+I +TPLH+A+ E
Sbjct: 598 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK---QGVTPLHLASQ---E 651
Query: 596 EGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPE 655
+V LLL K ++ + K G L ++ + + D
Sbjct: 652 GHTDMVTLLLD-------KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 704
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLW-SGHSPLSLSIASGNELVVKEL 714
+ G T L +AC + +V LL GAN N +G++PL + G+ ++ L
Sbjct: 705 KLGYTPLIVACHYGNVK-----MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 759
Query: 715 LTQGADPNLPLTKGLGSALCVACDLTY 741
L GA PN G +AL +A L Y
Sbjct: 760 LQHGAKPNATTANG-NTALAIAKRLGY 785
Score = 43.9 bits (102), Expect = 7e-04
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N I L + A ++ +G T L A+ H D+V LLLD GA+++ + G
Sbjct: 615 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 674
Query: 327 LTALSMCFLLHYPAQSFKPNVAE 349
LT+ LH AQ K NVA+
Sbjct: 675 LTS------LHLAAQEDKVNVAD 691
Score = 40.8 bits (94), Expect = 0.006
Identities = 62/235 (26%), Positives = 96/235 (40%), Gaps = 19/235 (8%)
Query: 506 SSFDKGTMR-RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVR 563
SS D T + AL + + +K+L++ GA+ N L++A + +D V+
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
Query: 564 LLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYK 623
LLE+GA TPL +A + Q V +LL D K
Sbjct: 127 YLLENGANQSTATE---DGFTPLAVALQ---QGHNQAVAILLE--NDTKGKVRLPALHIA 178
Query: 624 PGKLDLLPSSLKLSNEPGPP-QAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLL 682
K D ++L L N+ Q+ + E G T LH+A + N + LL
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNRTT--ESGFTPLHIAAHYGNVN-----VATLL 231
Query: 683 LSHGANPNLLW-SGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVA 736
L+ GA + +G +PL ++ GN +VK LL +G + GL C A
Sbjct: 232 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 286
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKC 322
+I+ GN + + +LK A+ + GYT L AA H I+N+LL GA N
Sbjct: 711 LIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 769
Query: 323 SDEGLTALSMCFLLHY 338
+ G TAL++ L Y
Sbjct: 770 TANGNTALAIAKRLGY 785
Score = 34.7 bits (78), Expect = 0.43
Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
L A+EG H + + L +S D A KG T L A+ ++V +L+ GA++N S
Sbjct: 49 LAAKEG-HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 107
Query: 325 EGLTALSM 332
G T L M
Sbjct: 108 NGFTPLYM 115
Score = 33.5 bits (75), Expect = 0.96
Identities = 18/56 (32%), Positives = 29/56 (51%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
I ++L + A D A GYT L +A D+ ++LL+ GA + + +G T L
Sbjct: 491 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 546
Score = 33.1 bits (74), Expect = 1.2
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG + + +L + A+ +A KG+T L AA + D+ LLL A +
Sbjct: 515 ISAREGQVD-VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 573
Query: 325 EGLTALSMCFLLHYPAQ 341
GLT L + HY Q
Sbjct: 574 NGLTPLHVA--AHYDNQ 588
Score = 32.7 bits (73), Expect = 1.6
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
++ GN + ++L D D G T L AA H+ +V LLL+ GA + + G
Sbjct: 253 SKRGNTNMV-KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 311
Query: 327 LTALSM 332
L+ L M
Sbjct: 312 LSPLHM 317
Score = 32.0 bits (71), Expect = 2.8
Identities = 29/102 (28%), Positives = 44/102 (43%), Gaps = 17/102 (16%)
Query: 248 SGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHND 307
SGF P + + A GN + +L + A+ D G T L A+ + +
Sbjct: 211 SGFTP----------LHIAAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 308 IVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 349
+V LLLD G ++ + +GLT LH A+S V E
Sbjct: 260 MVKLLLDRGGQIDAKTRDGLTP------LHCAARSGHDQVVE 295
Score = 31.6 bits (70), Expect = 3.6
Identities = 20/56 (35%), Positives = 27/56 (48%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ IL + A D GYT L A + + +VN LL GA+VN + G T L
Sbjct: 689 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 744
Score = 31.2 bits (69), Expect = 4.7
Identities = 18/62 (29%), Positives = 31/62 (50%)
Query: 271 NHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+++ + +L + AS GYT L AA I + LL+ GA+ N + +G+T L
Sbjct: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 645
Query: 331 SM 332
+
Sbjct: 646 HL 647
Score = 30.4 bits (67), Expect = 8.1
Identities = 18/56 (32%), Positives = 28/56 (50%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ ++L A+AD A G T L AA + + + LLL+ GA + + G T L
Sbjct: 557 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 612
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 58.9 bits (141), Expect = 2e-08
Identities = 75/285 (26%), Positives = 117/285 (41%), Gaps = 62/285 (21%)
Query: 530 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 588
+ LLL+ GA P++ + + L +A +AG V+ VR LL +GA D TPLHI
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD---ARAREEQTPLHI 503
Query: 589 AAALPGEEGVQIVELLLHAITDVDAKASDE----DDTYKPGKLDLLPSSLK------LSN 638
A+ L E IV+LLL + DA ++ + + G++D+ L+ L+
Sbjct: 504 ASRLGKTE---IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 639 EPG-----PPQAYYSTDTA-----------LPEEGGRTALHMACEREDDNKCARDIVRLL 682
+ G Y S D A + G T LH+A ++ + + LL
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN-----QKVALLL 615
Query: 683 LSHGANPN-LLWSGHSPLSLSIASGNELVVKELLTQGADPN------------------- 722
L GA+P+ +G++PL ++ + LL GA+ N
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 723 ----LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGAD 763
L L KG + LT H + K+ + D L HGAD
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Score = 57.0 bits (136), Expect = 8e-08
Identities = 117/498 (23%), Positives = 192/498 (38%), Gaps = 90/498 (18%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L A+ + G+T L AA H D+V LL+ GA+ + +++G T L++
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 335 -----------------------LLHYPAQSFKPNVAERTIPEPQE---PPKFPVVPILS 368
LH A+ A + K V
Sbjct: 172 QQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
Query: 369 SSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS 428
S F ++ + Y VNV A LLL R G D G
Sbjct: 232 SGFTPLHIAAHYGNVNV------------ATLLLNR-------GAAVDFTARNGITPLHV 272
Query: 429 SSLKGDSPLVKGSL---GHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAM 485
+S +G++ +VK L G +++ D L C+A + + V + +E +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH----CAARSGHDQ---VVELLLERGAPL 325
Query: 486 LERSAQSHSLLKMASPS---PCT-------SSFDKGTMRRM-ALSMIERRKRWRTIKLLL 534
L R+ S L MA+ C + D T+ + AL + +R KLLL
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385
Query: 535 RRGADPNLCCV-PMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALP 593
+ A+PN + L +A K + + LL+++GA S LTP+H+AA +
Sbjct: 386 DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE---SGLTPIHVAAFM- 441
Query: 594 GEEGVQIVELLLHAITDVDAKASDE--DDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDT 651
G + ++ L A DV + + G+++++ L+ D
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG---------ALVDA 492
Query: 652 ALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPN-LLWSGHSPLSLSIASGNELV 710
EE +T LH+A +IV+LLL H A+P+ +G++PL +S G V
Sbjct: 493 RAREE--QTPLHIA-----SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 711 VKELLTQGADPNLPLTKG 728
LL GA +L KG
Sbjct: 546 ASVLLEAGAAHSLATKKG 563
Score = 47.4 bits (111), Expect = 6e-05
Identities = 68/267 (25%), Positives = 112/267 (41%), Gaps = 38/267 (14%)
Query: 478 SIELSQAMLERSAQSHSLLKMA-SPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRR 536
S+++++ +L+R A + S K +P + +D +++AL LLL +
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN---QKVAL-------------LLLEK 618
Query: 537 GADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGE 595
GA P+ L +A K + LL +GA T+I +TPLH+A+ E
Sbjct: 619 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK---QGVTPLHLASQ---E 672
Query: 596 EGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPE 655
+V LLL K ++ + K G L ++ + + D
Sbjct: 673 GHTDMVTLLLD-------KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 725
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLW-SGHSPLSLSIASGNELVVKEL 714
+ G T L +AC + +V LL GAN N +G++PL + G+ ++ L
Sbjct: 726 KLGYTPLIVACHYGNVK-----MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 715 LTQGADPNLPLTKGLGSALCVACDLTY 741
L GA PN G +AL +A L Y
Sbjct: 781 LQHGAKPNATTANG-NTALAIAKRLGY 806
Score = 43.9 bits (102), Expect = 7e-04
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N I L + A ++ +G T L A+ H D+V LLLD GA+++ + G
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 327 LTALSMCFLLHYPAQSFKPNVAE 349
LT+ LH AQ K NVA+
Sbjct: 696 LTS------LHLAAQEDKVNVAD 712
Score = 40.8 bits (94), Expect = 0.006
Identities = 62/235 (26%), Positives = 96/235 (40%), Gaps = 19/235 (8%)
Query: 506 SSFDKGTMR-RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVR 563
SS D T + AL + + +K+L++ GA+ N L++A + +D V+
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Query: 564 LLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYK 623
LLE+GA TPL +A + Q V +LL D K
Sbjct: 148 YLLENGANQSTATE---DGFTPLAVALQ---QGHNQAVAILLE--NDTKGKVRLPALHIA 199
Query: 624 PGKLDLLPSSLKLSNEPGPP-QAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLL 682
K D ++L L N+ Q+ + E G T LH+A + N + LL
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTT--ESGFTPLHIAAHYGNVN-----VATLL 252
Query: 683 LSHGANPNLLW-SGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVA 736
L+ GA + +G +PL ++ GN +VK LL +G + GL C A
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKC 322
+I+ GN + + +LK A+ + GYT L AA H I+N+LL GA N
Sbjct: 732 LIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 323 SDEGLTALSMCFLLHY 338
+ G TAL++ L Y
Sbjct: 791 TANGNTALAIAKRLGY 806
Score = 34.7 bits (78), Expect = 0.43
Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
L A+EG H + + L +S D A KG T L A+ ++V +L+ GA++N S
Sbjct: 70 LAAKEG-HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Query: 325 EGLTALSM 332
G T L M
Sbjct: 129 NGFTPLYM 136
Score = 33.5 bits (75), Expect = 0.96
Identities = 18/56 (32%), Positives = 29/56 (51%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
I ++L + A D A GYT L +A D+ ++LL+ GA + + +G T L
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567
Score = 33.1 bits (74), Expect = 1.2
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG + + +L + A+ +A KG+T L AA + D+ LLL A +
Sbjct: 536 ISAREGQVD-VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594
Query: 325 EGLTALSMCFLLHYPAQ 341
GLT L + HY Q
Sbjct: 595 NGLTPLHVA--AHYDNQ 609
Score = 32.7 bits (73), Expect = 1.6
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
++ GN + ++L D D G T L AA H+ +V LLL+ GA + + G
Sbjct: 274 SKRGNTNMV-KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 327 LTALSM 332
L+ L M
Sbjct: 333 LSPLHM 338
Score = 32.0 bits (71), Expect = 2.8
Identities = 29/102 (28%), Positives = 44/102 (43%), Gaps = 17/102 (16%)
Query: 248 SGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHND 307
SGF P + + A GN + +L + A+ D G T L A+ + +
Sbjct: 232 SGFTP----------LHIAAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 308 IVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 349
+V LLLD G ++ + +GLT LH A+S V E
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTP------LHCAARSGHDQVVE 316
Score = 31.6 bits (70), Expect = 3.6
Identities = 20/56 (35%), Positives = 27/56 (48%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ IL + A D GYT L A + + +VN LL GA+VN + G T L
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Score = 31.2 bits (69), Expect = 4.7
Identities = 18/62 (29%), Positives = 31/62 (50%)
Query: 271 NHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+++ + +L + AS GYT L AA I + LL+ GA+ N + +G+T L
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Query: 331 SM 332
+
Sbjct: 667 HL 668
Score = 30.4 bits (67), Expect = 8.1
Identities = 18/56 (32%), Positives = 28/56 (50%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ ++L A+AD A G T L AA + + + LLL+ GA + + G T L
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 58.9 bits (141), Expect = 2e-08
Identities = 75/285 (26%), Positives = 117/285 (41%), Gaps = 62/285 (21%)
Query: 530 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 588
+ LLL+ GA P++ + + L +A +AG V+ VR LL +GA D TPLHI
Sbjct: 447 VLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVD---ARAREEQTPLHI 503
Query: 589 AAALPGEEGVQIVELLLHAITDVDAKASDE----DDTYKPGKLDLLPSSLK------LSN 638
A+ L E IV+LLL + DA ++ + + G++D+ L+ L+
Sbjct: 504 ASRLGKTE---IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLAT 560
Query: 639 EPG-----PPQAYYSTDTA-----------LPEEGGRTALHMACEREDDNKCARDIVRLL 682
+ G Y S D A + G T LH+A ++ + + LL
Sbjct: 561 KKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN-----QKVALLL 615
Query: 683 LSHGANPN-LLWSGHSPLSLSIASGNELVVKELLTQGADPN------------------- 722
L GA+P+ +G++PL ++ + LL GA+ N
Sbjct: 616 LEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHT 675
Query: 723 ----LPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGAD 763
L L KG + LT H + K+ + D L HGAD
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGAD 720
Score = 57.0 bits (136), Expect = 8e-08
Identities = 117/498 (23%), Positives = 192/498 (38%), Gaps = 90/498 (18%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCF 334
+ ++L A+ + G+T L AA H D+V LL+ GA+ + +++G T L++
Sbjct: 112 VVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVAL 171
Query: 335 -----------------------LLHYPAQSFKPNVAERTIPEPQE---PPKFPVVPILS 368
LH A+ A + K V
Sbjct: 172 QQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTE 231
Query: 369 SSFMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRS 428
S F ++ + Y VNV A LLL R G D G
Sbjct: 232 SGFTPLHIAAHYGNVNV------------ATLLLNR-------GAAVDFTARNGITPLHV 272
Query: 429 SSLKGDSPLVKGSL---GHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAM 485
+S +G++ +VK L G +++ D L C+A + + V + +E +
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLH----CAARSGHDQ---VVELLLERGAPL 325
Query: 486 LERSAQSHSLLKMASPS---PCT-------SSFDKGTMRRM-ALSMIERRKRWRTIKLLL 534
L R+ S L MA+ C + D T+ + AL + +R KLLL
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLL 385
Query: 535 RRGADPNLCCV-PMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALP 593
+ A+PN + L +A K + + LL+++GA S LTP+H+AA +
Sbjct: 386 DKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITE---SGLTPIHVAAFM- 441
Query: 594 GEEGVQIVELLLHAITDVDAKASDE--DDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDT 651
G + ++ L A DV + + G+++++ L+ D
Sbjct: 442 GHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNG---------ALVDA 492
Query: 652 ALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPN-LLWSGHSPLSLSIASGNELV 710
EE +T LH+A +IV+LLL H A+P+ +G++PL +S G V
Sbjct: 493 RAREE--QTPLHIA-----SRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDV 545
Query: 711 VKELLTQGADPNLPLTKG 728
LL GA +L KG
Sbjct: 546 ASVLLEAGAAHSLATKKG 563
Score = 47.4 bits (111), Expect = 6e-05
Identities = 68/267 (25%), Positives = 112/267 (41%), Gaps = 38/267 (14%)
Query: 478 SIELSQAMLERSAQSHSLLKMA-SPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRR 536
S+++++ +L+R A + S K +P + +D +++AL LLL +
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDN---QKVAL-------------LLLEK 618
Query: 537 GADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGE 595
GA P+ L +A K + LL +GA T+I +TPLH+A+ E
Sbjct: 619 GASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTK---QGVTPLHLASQ---E 672
Query: 596 EGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPE 655
+V LLL K ++ + K G L ++ + + D
Sbjct: 673 GHTDMVTLLLD-------KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHT 725
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLW-SGHSPLSLSIASGNELVVKEL 714
+ G T L +AC + +V LL GAN N +G++PL + G+ ++ L
Sbjct: 726 KLGYTPLIVACHYGNVK-----MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVL 780
Query: 715 LTQGADPNLPLTKGLGSALCVACDLTY 741
L GA PN G +AL +A L Y
Sbjct: 781 LQHGAKPNATTANG-NTALAIAKRLGY 806
Score = 43.9 bits (102), Expect = 7e-04
Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N I L + A ++ +G T L A+ H D+V LLLD GA+++ + G
Sbjct: 636 AAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSG 695
Query: 327 LTALSMCFLLHYPAQSFKPNVAE 349
LT+ LH AQ K NVA+
Sbjct: 696 LTS------LHLAAQEDKVNVAD 712
Score = 40.8 bits (94), Expect = 0.006
Identities = 62/235 (26%), Positives = 96/235 (40%), Gaps = 19/235 (8%)
Query: 506 SSFDKGTMR-RMALSMIERRKRWRTIKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVR 563
SS D T + AL + + +K+L++ GA+ N L++A + +D V+
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Query: 564 LLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYK 623
LLE+GA TPL +A + Q V +LL D K
Sbjct: 148 YLLENGANQSTATE---DGFTPLAVALQ---QGHNQAVAILLE--NDTKGKVRLPALHIA 199
Query: 624 PGKLDLLPSSLKLSNEPGPP-QAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLL 682
K D ++L L N+ Q+ + E G T LH+A + N + LL
Sbjct: 200 ARKDDTKSAALLLQNDHNADVQSKMMVNRTT--ESGFTPLHIAAHYGNVN-----VATLL 252
Query: 683 LSHGANPNLLW-SGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVA 736
L+ GA + +G +PL ++ GN +VK LL +G + GL C A
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAA 307
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/76 (34%), Positives = 38/76 (50%), Gaps = 1/76 (1%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKC 322
+I+ GN + + +LK A+ + GYT L AA H I+N+LL GA N
Sbjct: 732 LIVACHYGNVKMVNFLLKQG-ANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNAT 790
Query: 323 SDEGLTALSMCFLLHY 338
+ G TAL++ L Y
Sbjct: 791 TANGNTALAIAKRLGY 806
Score = 34.7 bits (78), Expect = 0.43
Identities = 24/68 (35%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
L A+EG H + + L +S D A KG T L A+ ++V +L+ GA++N S
Sbjct: 70 LAAKEG-HVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQ 128
Query: 325 EGLTALSM 332
G T L M
Sbjct: 129 NGFTPLYM 136
Score = 33.5 bits (75), Expect = 0.96
Identities = 18/56 (32%), Positives = 29/56 (51%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
I ++L + A D A GYT L +A D+ ++LL+ GA + + +G T L
Sbjct: 512 IVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPL 567
Score = 33.1 bits (74), Expect = 1.2
Identities = 24/77 (31%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
+ A EG + + +L + A+ +A KG+T L AA + D+ LLL A +
Sbjct: 536 ISAREGQVD-VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594
Query: 325 EGLTALSMCFLLHYPAQ 341
GLT L + HY Q
Sbjct: 595 NGLTPLHVA--AHYDNQ 609
Score = 32.7 bits (73), Expect = 1.6
Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 1/66 (1%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
++ GN + ++L D D G T L AA H+ +V LLL+ GA + + G
Sbjct: 274 SKRGNTNMV-KLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNG 332
Query: 327 LTALSM 332
L+ L M
Sbjct: 333 LSPLHM 338
Score = 32.0 bits (71), Expect = 2.8
Identities = 29/102 (28%), Positives = 44/102 (43%), Gaps = 17/102 (16%)
Query: 248 SGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHND 307
SGF P + + A GN + +L + A+ D G T L A+ + +
Sbjct: 232 SGFTP----------LHIAAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 308 IVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAE 349
+V LLLD G ++ + +GLT LH A+S V E
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTP------LHCAARSGHDQVVE 316
Score = 31.6 bits (70), Expect = 3.6
Identities = 20/56 (35%), Positives = 27/56 (48%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ IL + A D GYT L A + + +VN LL GA+VN + G T L
Sbjct: 710 VADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPL 765
Score = 31.2 bits (69), Expect = 4.7
Identities = 18/62 (29%), Positives = 31/62 (50%)
Query: 271 NHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+++ + +L + AS GYT L AA I + LL+ GA+ N + +G+T L
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPL 666
Query: 331 SM 332
+
Sbjct: 667 HL 668
Score = 30.4 bits (67), Expect = 8.1
Identities = 18/56 (32%), Positives = 28/56 (50%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ ++L A+AD A G T L AA + + + LLL+ GA + + G T L
Sbjct: 578 VAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 57.4 bits (137), Expect = 6e-08
Identities = 114/496 (22%), Positives = 184/496 (37%), Gaps = 92/496 (18%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + ++L D A+ + G+T L A ++ LLL GA + ++ GLT
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP-- 436
Query: 332 MCFLLHYPAQSFKPNVAERTIPEPQEPPKFPV--VPILSSSFMDTNLESLYYEVNVPSQG 389
+H A N+ + + P V L + E + Y V +Q
Sbjct: 437 ----IHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV 492
Query: 390 SYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGSLGHVESGL 449
+ + PL + G + Q Q G S + ++S G +PL + G
Sbjct: 493 EAKAKDDQTPLHISARLG--KADIVQQLLQQGASPNAATTS--GYTPLHLSA----REGH 544
Query: 450 EDVLG-NTDRGSLCSAETK---FESNVCVCDFSIELSQAMLERSAQSHSLLKMA-SPSPC 504
EDV D G+ S TK +V +E++ +L++SA + K +P
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 505 TSSFDKGTMRRMALS-----------------MIERRKRWRTIKLLLRRGADPN-LCCVP 546
+ +D + + L + ++ + LL GAD N +
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664
Query: 547 MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLH 606
+ + LA + G VD V LLL A ++ S LTPLH+AA E+ V + E+L++
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNL---SNKSGLTPLHLAAQ---EDRVNVAEVLVN 718
Query: 607 AITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMAC 666
VDA+ + G T LH+ C
Sbjct: 719 QGAHVDAQT----------------------------------------KMGYTPLHVGC 738
Query: 667 EREDDNKCARDIVRLLLSHGANPNL-LWSGHSPLSLSIASGNELVVKELLTQGADPNLPL 725
+ IV LL H A N +G++PL + G+ ++ LL A PN L
Sbjct: 739 HYGNIK-----IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPN-EL 792
Query: 726 TKGLGSALCVACDLTY 741
T +AL +A L Y
Sbjct: 793 TVNGNTALGIARRLGY 808
Score = 50.1 bits (118), Expect = 1e-05
Identities = 114/497 (22%), Positives = 188/497 (37%), Gaps = 74/497 (14%)
Query: 247 RSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHN 306
+SGF P + + A GN + +L + A+ D T L A+ +
Sbjct: 233 KSGFTP----------LHIAAHYGNIN-VATLLLNRAAAVDFTARNDITPLHVASKRGNA 281
Query: 307 DIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPI 366
++V LLLD GA ++ + +GLT LH A+S V E + PI
Sbjct: 282 NMVKLLLDRGAKIDAKTRDGLTP------LHCGARSGHEQVVEMLLDR--------AAPI 327
Query: 367 LSSSFMDTNLESLYYEVNVPSQGSYEL----RPPPAPLLLPRVSGSHEGGHFQDTGQCGG 422
LS + L L+ +L P + ++ H H
Sbjct: 328 LSKT--KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKV 385
Query: 423 SIDHRSS----SLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFS 478
+D +++ +L G +PL + +E +L G+ A T ES + +
Sbjct: 386 LLDKKANPNAKALNGFTPLHIACKKNRIKVMELLL---KHGASIQAVT--ESGLTPIHVA 440
Query: 479 IELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGA 538
+ + H SP T++ T AL M R + ++ L++ GA
Sbjct: 441 AFMGHVNIVSQLMHH------GASPNTTNVRGET----ALHMAARSGQAEVVRYLVQDGA 490
Query: 539 DPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEG 597
Q L ++ + G D V+ LL+ GA + S TPLH++A G E
Sbjct: 491 QVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAA---TTSGYTPLHLSAR-EGHED 546
Query: 598 VQIVELLLHAITDVDAKA--SDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPE 655
V L A + K + K GKL++ ++L L P A
Sbjct: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEV--ANLLLQKSASPDAA---------G 595
Query: 656 EGGRTALHMACEREDDNKCARDIVRLLLSHGANPN-LLWSGHSPLSLSIASGNELVVKEL 714
+ G T LH+A ++ + + LLL GA+P+ +G++PL ++ + L
Sbjct: 596 KSGLTPLHVAAHYDN-----QKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTL 650
Query: 715 LTQGADPNLPLTKGLGS 731
L GAD N +G+ S
Sbjct: 651 LEYGADANAVTRQGIAS 667
Score = 42.0 bits (97), Expect = 0.003
Identities = 34/113 (30%), Positives = 49/113 (43%), Gaps = 6/113 (5%)
Query: 232 PAHTSWNMGA---ILEGKRSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADV 288
P H S +G + + + G +P + L A EG HE + L D+ AS +
Sbjct: 502 PLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREG-HEDVAAFLLDHGASLSI 560
Query: 289 ADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQ 341
KG+T L AA + ++ NLLL A + GLT L + HY Q
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVA--AHYDNQ 611
Score = 40.8 bits (94), Expect = 0.006
Identities = 77/355 (21%), Positives = 138/355 (38%), Gaps = 44/355 (12%)
Query: 423 SIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELS 482
S D + S S L GH+E L+ + D ++C+ ++ + +E+
Sbjct: 32 SRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDI-NICNQNGLNALHLASKEGHVEVV 90
Query: 483 QAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNL 542
+L+R A + K + AL + + +K+L+ GA+ N
Sbjct: 91 SELLQREANVDAATKKGNT---------------ALHIASLAGQAEVVKVLVTNGANVNA 135
Query: 543 CCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIV 601
L++A + ++ V+ LL++GA + TPL +A + Q+V
Sbjct: 136 QSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATE---DGFTPLAVALQQGHD---QVV 189
Query: 602 ELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTA 661
LLL D K K D ++L L N+ + + + G T
Sbjct: 190 SLLLE--NDTKGKVRLPALHIAARKDDTKAAALLLQND---------NNADVESKSGFTP 238
Query: 662 LHMACEREDDNKCARDIVRLLLSHGANPNLLWSGH-SPLSLSIASGNELVVKELLTQGAD 720
LH+A + N + LLL+ A + +PL ++ GN +VK LL +GA
Sbjct: 239 LHIAAHYGNIN-----VATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAK 293
Query: 721 PNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPV-MLRQGE 774
+ GL + C H++ ++ L ++S + L P+ M QG+
Sbjct: 294 IDAKTRDGLTP---LHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGD 345
Score = 37.4 bits (85), Expect = 0.066
Identities = 24/68 (35%), Positives = 37/68 (54%), Gaps = 1/68 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
L ++EG+ E + +L+ A+ D A KG T L A+ ++V +L+ GA+VN S
Sbjct: 80 LASKEGHVEVVSELLQRE-ANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQ 138
Query: 325 EGLTALSM 332
G T L M
Sbjct: 139 NGFTPLYM 146
Score = 37.4 bits (85), Expect = 0.066
Identities = 18/58 (31%), Positives = 32/58 (55%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 332
+ ++L N A+ + G+T L AA H ++V LLD GA + +++G T L++
Sbjct: 122 VVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAV 179
Score = 37.4 bits (85), Expect = 0.066
Identities = 19/48 (39%), Positives = 28/48 (58%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLD 314
A + NH + + L DN AS +A G+T LA A H+ +V+LLL+
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE 194
Score = 37.4 bits (85), Expect = 0.066
Identities = 29/83 (34%), Positives = 39/83 (46%), Gaps = 6/83 (7%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + N I L + A A+ +G + AA H D+V+LLL A+VN + G
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 327 LTALSMCFLLHYPAQSFKPNVAE 349
LT LH AQ + NVAE
Sbjct: 698 LTP------LHLAAQEDRVNVAE 714
Score = 36.6 bits (83), Expect = 0.11
Identities = 20/62 (32%), Positives = 32/62 (51%)
Query: 271 NHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+++ + +L D AS A GYT L AA DI LL+ GAD N + +G+ ++
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASV 668
Query: 331 SM 332
+
Sbjct: 669 HL 670
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 57.4 bits (137), Expect = 6e-08
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 77/294 (26%)
Query: 517 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDIC 575
AL + + W+ +++LL GADPN + LFLAV+ G +D +RLLL+HGA ++
Sbjct: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA--NVN 66
Query: 576 FPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKP-------GKLD 628
+ LH A+ +E +I++LLL + K +D P GKL+
Sbjct: 67 GSHSMCGWNSLHQASF---QENAEIIKLLLRKGAN---KECQDDFGITPLFVAAQYGKLE 120
Query: 629 LLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGAN 688
SL + G + D A P L +A + E KC V LLLS GA+
Sbjct: 121 ----SLSILISSGANVNCQALDKATP-------LFIAAQ-EGHTKC----VELLLSSGAD 164
Query: 689 PNLL-----WS---------GH----------------------SPLSLSIASGNELVVK 712
P+L W GH SP+ ++ G+E ++
Sbjct: 165 PDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLE 224
Query: 713 ELLTQGADPNLP--LTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
LL G P+ L G S +C+A E +++ L+ +GA I
Sbjct: 225 ILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEF-------FGIVNILLKYGAQI 271
Score = 31.6 bits (70), Expect = 3.6
Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 15/107 (14%)
Query: 658 GRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHS-PLSLSIASGNELVVKELLT 716
G ALH+A + IV++LL GA+PN + PL L++ +G V++ LL
Sbjct: 6 GFCALHLAASQGHWK-----IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 60
Query: 717 QGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGAD 763
GA+ N GS C HQ + +I L+ GA+
Sbjct: 61 HGANVN-------GSH--SMCGWNSLHQASFQENAEIIKLLLRKGAN 98
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 57.4 bits (137), Expect = 6e-08
Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 77/294 (26%)
Query: 517 ALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDIC 575
AL + + W+ +++LL GADPN + LFLAV+ G +D +RLLL+HGA ++
Sbjct: 82 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA--NVN 139
Query: 576 FPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKP-------GKLD 628
+ LH A+ +E +I++LLL + K +D P GKL+
Sbjct: 140 GSHSMCGWNSLHQASF---QENAEIIKLLLRKGAN---KECQDDFGITPLFVAAQYGKLE 193
Query: 629 LLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGAN 688
SL + G + D A P L +A + E KC V LLLS GA+
Sbjct: 194 ----SLSILISSGANVNCQALDKATP-------LFIAAQ-EGHTKC----VELLLSSGAD 237
Query: 689 PNLL-----WS---------GH----------------------SPLSLSIASGNELVVK 712
P+L W GH SP+ ++ G+E ++
Sbjct: 238 PDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLE 297
Query: 713 ELLTQGADPNLP--LTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
LL G P+ L G S +C+A E +++ L+ +GA I
Sbjct: 298 ILLRNGYSPDAQACLVFGFSSPVCMAFQKDCEF-------FGIVNILLKYGAQI 344
Score = 31.6 bits (70), Expect = 3.6
Identities = 32/107 (29%), Positives = 48/107 (44%), Gaps = 15/107 (14%)
Query: 658 GRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHS-PLSLSIASGNELVVKELLT 716
G ALH+A + IV++LL GA+PN + PL L++ +G V++ LL
Sbjct: 79 GFCALHLAASQGHWK-----IVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQ 133
Query: 717 QGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGAD 763
GA+ N GS C HQ + +I L+ GA+
Sbjct: 134 HGANVN-------GSH--SMCGWNSLHQASFQENAEIIKLLLRKGAN 171
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 57.0 bits (136), Expect = 8e-08
Identities = 133/539 (24%), Positives = 208/539 (38%), Gaps = 127/539 (23%)
Query: 264 ILKAEEGNHEWICRILKDNFASADVADAKG-YTVLAAAATHCHNDIVNLLLDCGADVNKC 322
++KA H + L A+ + A +TVL+ A H +V LLL GAD
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
Query: 323 SDEGLTALS----------MCFLLHYPAQSFK---PNVAERTIPE--------------- 354
+G T L +C+LL YP P+V + T P
Sbjct: 694 LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALP 753
Query: 355 ----PQEPPKFPV-----VPILS-------SSFMDTNLESLYYEVNVPSQGSYELRPPPA 398
PQEP K P +PI + S+ +T S+ ++ P P P+
Sbjct: 754 MVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQT------PTPS 807
Query: 399 PLLLP--------------RVSGSHE--------GGH---FQDTGQCGGSIDHRSSSLKG 433
P++ P + +H+ GGH Q + G SI+HR KG
Sbjct: 808 PIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDK--KG 865
Query: 434 DSPLV-KGSLGHVESGLEDVLGNTDRGSLCSAE---TKFESNVCVCDFSI-ELSQAMLER 488
+PL+ + GHV G+ ++L D G+ A+ TK C E+ + +L R
Sbjct: 866 FTPLILAATAGHV--GVVEIL--LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLAR 921
Query: 489 SA-QSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCC--- 544
A + H + +P LS+ IK+LL GA+ N
Sbjct: 922 GANKEHRNVSDYTP----------------LSLAASGGYVNIIKILLNAGAEINSRTGSK 965
Query: 545 VPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELL 604
+ + L LA G V+LLL+ G+ DI + + T L +A + ++V LL
Sbjct: 966 LGISPLMLAAMNGHTAAVKLLLDMGS--DINAQIETNRNTALTLACF---QGRTEVVSLL 1020
Query: 605 LHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPE--EGGRTAL 662
L +V+ +A K G L+ ++ E G D P TAL
Sbjct: 1021 LDRKANVEHRA-------KTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTAL 1073
Query: 663 HMACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNELVVKELLTQGAD 720
+A ++ C LL+ GA+ ++ G++PL L+ G+ VV+ L+ GAD
Sbjct: 1074 TIAADKGHYKFC-----ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGAD 1127
Score = 55.8 bits (133), Expect = 2e-07
Identities = 125/476 (26%), Positives = 194/476 (40%), Gaps = 59/476 (12%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKG-YTVLAAAATHCHNDIVNLLLDCGADVNK 321
+ L G +E + ++L A+ + KG T L AAA H IV LLL ADVN
Sbjct: 271 LCLACSAGYYE-LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNA 329
Query: 322 CSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYY 381
S G TAL+ Y + +I + E P++ S+ ++ + L
Sbjct: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE--VARLLL 387
Query: 382 EVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGS 441
E N ++ + L L G E F + G +H++ + + L++
Sbjct: 388 E-NGAGINTHSNEFKESALTLACYKGHLEMVRF--LLEAGADQEHKTDEM--HTALMEAC 442
Query: 442 L-GHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMAS 500
+ GHVE +L + + ++ + + + C +EL+ ++ER A +
Sbjct: 443 MDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV----- 496
Query: 501 PSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQ--VLFLAVKAGD 558
D+G M + R + LLL +GA+ N Q L LA G
Sbjct: 497 -------NDEGYTPLMEAA---REGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 559 VDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE 618
++ L++ GA DI +L TPL AA E +++V+ LL A +V A +
Sbjct: 547 LEVADFLIKAGA--DI----ELGCSTPLMEAAQ---EGHLELVKYLLAAGANVHATTATG 597
Query: 619 DD--TY--KPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKC 674
D TY + G D+ L+ D EGGRT L A + C
Sbjct: 598 DTALTYACENGHTDVADVLLQA-----------GADLEHESEGGRTPLMKAARA--GHVC 644
Query: 675 ARDIVRLLLSHGANPNLLWSG--HSPLSLSIASGNELVVKELLTQGADPNLPLTKG 728
V+ L+S GAN N + H+ LSL+ A G+ VV+ LL GADP L G
Sbjct: 645 T---VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG 697
Score = 47.4 bits (111), Expect = 6e-05
Identities = 70/272 (25%), Positives = 108/272 (39%), Gaps = 55/272 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L LA G + V+ LLE GA + TPL I AA G GV VE+LL
Sbjct: 836 LTLACAGGHEELVQTLLERGASIE---HRDKKGFTPL-ILAATAGHVGV--VEILLDNGA 889
Query: 610 DVDAKASDEDDT-----YKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHM 664
D++A++ DT G+ +++ L T +L GG
Sbjct: 890 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV---- 945
Query: 665 ACEREDDNKCARDIVRLLLSHGANPNLLWS---GHSPLSLSIASGNELVVKELLTQGADP 721
+I+++LL+ GA N G SPL L+ +G+ VK LL G+D
Sbjct: 946 ------------NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993
Query: 722 NLPLTKGLGSALCVAC--------DLTYEHQRNMDSK---------------LALIDR-L 757
N + +AL +AC L + + N++ + A + R L
Sbjct: 994 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053
Query: 758 ISHGADILKPVMLRQGEKEAVGTAVDYGYFRF 789
+ GAD+ P + A+ A D G+++F
Sbjct: 1054 LDKGADVNAP-PVPSSRDTALTIAADKGHYKF 1084
Score = 43.9 bits (102), Expect = 7e-04
Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 1/72 (1%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKC 322
+ + A++G++++ C +L A DV + KG T L AA H D+V LL+ GADV+
Sbjct: 1073 LTIAADKGHYKF-CELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1131
Query: 323 SDEGLTALSMCF 334
+ +T L F
Sbjct: 1132 DNRKITPLMAAF 1143
Score = 42.7 bits (99), Expect = 0.002
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 68/374 (18%)
Query: 419 QCGGSIDHRSSSLKGDSPLVK-GSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVC-D 476
+ G SI+ + + G +PL++ GS GHVE +L N + S E K + C
Sbjct: 355 ESGASIEDHNEN--GHTPLMEAGSAGHVEVA-RLLLENGAGINTHSNEFKESALTLACYK 411
Query: 477 FSIELSQAMLERSA-QSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLR 535
+E+ + +LE A Q H T M +E +LLL
Sbjct: 412 GHLEMVRFLLEAGADQEHK----------TDEMHTALMEACMDGHVE------VARLLLD 455
Query: 536 RGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPG 594
GA N+ + L LA G V+ LL+E GA + TPL + AA G
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE---EVNDEGYTPL-MEAAREG 511
Query: 595 EEGVQIVELLLHAITDVDAKASDEDDTYKP-----GKLDLLPSSLKLSNE---------- 639
E ++V LLL +++A+ + +T G L++ +K +
Sbjct: 512 HE--EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLM 569
Query: 640 PGPPQAYYSTDTALPEEG---------GRTALHMACEREDDNKCARDIVRLLLSHGAN-P 689
+ + L G G TAL ACE D+ +LL GA+
Sbjct: 570 EAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT-----DVADVLLQAGADLE 624
Query: 690 NLLWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDS 749
+ G +PL + +G+ V+ L+++GA+ N + L +AC
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC---------AGG 675
Query: 750 KLALIDRLISHGAD 763
LA+++ L++HGAD
Sbjct: 676 HLAVVELLLAHGAD 689
Score = 42.0 bits (97), Expect = 0.003
Identities = 114/507 (22%), Positives = 184/507 (36%), Gaps = 115/507 (22%)
Query: 270 GNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD---EG 326
G H + +L + AS + + +GYT L AA H ++V LLL GA++N ++ E
Sbjct: 477 GGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQET 536
Query: 327 LTALSMC--FLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYYEVN 384
L+ C FL VA+ I + P++ ++ + +LE + Y +
Sbjct: 537 ALTLACCGGFL----------EVADFLIKAGADIELGCSTPLMEAA-QEGHLELVKYLLA 585
Query: 385 VPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTG---QCGGSIDHRSSSLKGDSPLVKGS 441
+ L + E GH Q G ++H S G +PL+K +
Sbjct: 586 AGANVHATTATGDTALTY-----ACENGHTDVADVLLQAGADLEHESEG--GRTPLMKAA 638
Query: 442 -LGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQS-HSLLKMA 499
GHV C F I + +A + H++L +A
Sbjct: 639 RAGHV---------------------------CTVQFLISKGANVNRTTANNDHTVLSLA 671
Query: 500 SPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQVLFL-AVKAGD 558
C L+++E LLL GADP + + A K G
Sbjct: 672 ----CAGGH---------LAVVE---------LLLAHGADPTHRLKDGSTMLIEAAKGGH 709
Query: 559 VDGVRLLLEHGARTDICFPPQLSTLTP-----------------LHIAAALPGEEGVQIV 601
V LL++ PP ++ LTP + + P + +
Sbjct: 710 TSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVA 769
Query: 602 ELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGP-----PQA----YYSTDT- 651
L V +AS +T + +S+ P P P A Y + D
Sbjct: 770 TTLPIRNKAVSGRASAMSNT----PTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDID 825
Query: 652 ALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGAN-PNLLWSGHSPLSLSIASGNELV 710
A E TAL +AC + ++V+ LL GA+ + G +PL L+ +G+ V
Sbjct: 826 AQTESNHDTALTLACAGGHE-----ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 880
Query: 711 VKELLTQGADPNLPLTKGLGSALCVAC 737
V+ LL GAD + + L +AC
Sbjct: 881 VEILLDNGADIEAQSERTKDTPLSLAC 907
Score = 36.6 bits (83), Expect = 0.11
Identities = 57/223 (25%), Positives = 87/223 (39%), Gaps = 41/223 (18%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDIC---FPPQLSTLTPLHIAAALPGEEGVQIVELLLH 606
L A AG V+ RLLLE+GA + F TL A G +++V LL
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL------ACYKGH--LEMVRFLLE 422
Query: 607 AITDVDAKASDED----DTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTAL 662
A D + K + + G +++ L + P + + L GG
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV-- 480
Query: 663 HMACEREDDNKCARDIVRLLLSHGAN-PNLLWSGHSPLSLSIASGNELVVKELLTQGADP 721
++ LL+ GA+ + G++PL + G+E +V LL QGA+
Sbjct: 481 --------------ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
Query: 722 NLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
N + +AL +AC L + D LI GADI
Sbjct: 527 NAQTEETQETALTLAC---------CGGFLEVADFLIKAGADI 560
Score = 35.4 bits (80), Expect = 0.25
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 1/71 (1%)
Query: 260 SMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADV 319
S ++ A+EG+ E + +L A+ A G T L A + H D+ ++LL GAD+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Query: 320 NKCSDEGLTAL 330
S+ G T L
Sbjct: 624 EHESEGGRTPL 634
Score = 34.7 bits (78), Expect = 0.43
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 647 YSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGAN-PNLLWSGHSPLSLSIAS 705
+ D G TAL AC D+V++LL GA+ + +GH+PL + ++
Sbjct: 323 HKADVNAQSSTGNTALTYACAGG-----YVDVVKVLLESGASIEDHNENGHTPLMEAGSA 377
Query: 706 GNELVVKELLTQGADPNLPLTKGLGSALCVAC 737
G+ V + LL GA N + SAL +AC
Sbjct: 378 GHVEVARLLLENGAGINTHSNEFKESALTLAC 409
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 55.8 bits (133), Expect = 2e-07
Identities = 125/476 (26%), Positives = 194/476 (40%), Gaps = 59/476 (12%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKG-YTVLAAAATHCHNDIVNLLLDCGADVNK 321
+ L G +E + ++L A+ + KG T L AAA H IV LLL ADVN
Sbjct: 271 LCLACSAGYYE-LAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNA 329
Query: 322 CSDEGLTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPILSSSFMDTNLESLYY 381
S G TAL+ Y + +I + E P++ S+ ++ + L
Sbjct: 330 QSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVE--VARLLL 387
Query: 382 EVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGS 441
E N ++ + L L G E F + G +H++ + + L++
Sbjct: 388 E-NGAGINTHSNEFKESALTLACYKGHLEMVRF--LLEAGADQEHKTDEM--HTALMEAC 442
Query: 442 L-GHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMAS 500
+ GHVE +L + + ++ + + + C +EL+ ++ER A +
Sbjct: 443 MDGHVEVA-RLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV----- 496
Query: 501 PSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQ--VLFLAVKAGD 558
D+G M + R + LLL +GA+ N Q L LA G
Sbjct: 497 -------NDEGYTPLMEAA---REGHEEMVALLLGQGANINAQTEETQETALTLACCGGF 546
Query: 559 VDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDE 618
++ L++ GA DI +L TPL AA E +++V+ LL A +V A +
Sbjct: 547 LEVADFLIKAGA--DI----ELGCSTPLMEAAQ---EGHLELVKYLLAAGANVHATTATG 597
Query: 619 DD--TY--KPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKC 674
D TY + G D+ L+ D EGGRT L A + C
Sbjct: 598 DTALTYACENGHTDVADVLLQA-----------GADLEHESEGGRTPLMKAARA--GHVC 644
Query: 675 ARDIVRLLLSHGANPNLLWSG--HSPLSLSIASGNELVVKELLTQGADPNLPLTKG 728
V+ L+S GAN N + H+ LSL+ A G+ VV+ LL GADP L G
Sbjct: 645 T---VQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDG 697
Score = 47.4 bits (111), Expect = 6e-05
Identities = 70/272 (25%), Positives = 108/272 (39%), Gaps = 55/272 (20%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L LA G + V+ LLE GA + TPL I AA G GV VE+LL
Sbjct: 1087 LTLACAGGHEELVQTLLERGASIE---HRDKKGFTPL-ILAATAGHVGV--VEILLDNGA 1140
Query: 610 DVDAKASDEDDT-----YKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHM 664
D++A++ DT G+ +++ L T +L GG
Sbjct: 1141 DIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYV---- 1196
Query: 665 ACEREDDNKCARDIVRLLLSHGANPNLLWS---GHSPLSLSIASGNELVVKELLTQGADP 721
+I+++LL+ GA N G SPL L+ +G+ VK LL G+D
Sbjct: 1197 ------------NIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
Query: 722 NLPLTKGLGSALCVAC--------DLTYEHQRNMDSK---------------LALIDR-L 757
N + +AL +AC L + + N++ + A + R L
Sbjct: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
Query: 758 ISHGADILKPVMLRQGEKEAVGTAVDYGYFRF 789
+ GAD+ P + A+ A D G+++F
Sbjct: 1305 LDKGADVNAP-PVPSSRDTALTIAADKGHYKF 1335
Score = 43.9 bits (102), Expect = 7e-04
Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 1/72 (1%)
Query: 263 MILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKC 322
+ + A++G++++ C +L A DV + KG T L AA H D+V LL+ GADV+
Sbjct: 1324 LTIAADKGHYKF-CELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAA 1382
Query: 323 SDEGLTALSMCF 334
+ +T L F
Sbjct: 1383 DNRKITPLMAAF 1394
Score = 43.1 bits (100), Expect = 0.001
Identities = 23/55 (41%), Positives = 32/55 (58%)
Query: 270 GNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
G HE + + L + AS + D KG+T L AAT H +V +LLD GAD+ S+
Sbjct: 1093 GGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSE 1147
Score = 42.7 bits (99), Expect = 0.002
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 68/374 (18%)
Query: 419 QCGGSIDHRSSSLKGDSPLVK-GSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVC-D 476
+ G SI+ + + G +PL++ GS GHVE +L N + S E K + C
Sbjct: 355 ESGASIEDHNEN--GHTPLMEAGSAGHVEVA-RLLLENGAGINTHSNEFKESALTLACYK 411
Query: 477 FSIELSQAMLERSA-QSHSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLR 535
+E+ + +LE A Q H T M +E +LLL
Sbjct: 412 GHLEMVRFLLEAGADQEHK----------TDEMHTALMEACMDGHVE------VARLLLD 455
Query: 536 RGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPG 594
GA N+ + L LA G V+ LL+E GA + TPL + AA G
Sbjct: 456 SGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLE---EVNDEGYTPL-MEAAREG 511
Query: 595 EEGVQIVELLLHAITDVDAKASDEDDTYKP-----GKLDLLPSSLKLSNE---------- 639
E ++V LLL +++A+ + +T G L++ +K +
Sbjct: 512 HE--EMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLM 569
Query: 640 PGPPQAYYSTDTALPEEG---------GRTALHMACEREDDNKCARDIVRLLLSHGAN-P 689
+ + L G G TAL ACE D+ +LL GA+
Sbjct: 570 EAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHT-----DVADVLLQAGADLE 624
Query: 690 NLLWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDS 749
+ G +PL + +G+ V+ L+++GA+ N + L +AC
Sbjct: 625 HESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC---------AGG 675
Query: 750 KLALIDRLISHGAD 763
LA+++ L++HGAD
Sbjct: 676 HLAVVELLLAHGAD 689
Score = 38.1 bits (87), Expect = 0.039
Identities = 86/325 (26%), Positives = 135/325 (41%), Gaps = 54/325 (16%)
Query: 411 GGH---FQDTGQCGGSIDHRSSSLKGDSPLV-KGSLGHVESGLEDVLGNTDRGSLCSAE- 465
GGH Q + G SI+HR KG +PL+ + GHV G+ ++L D G+ A+
Sbjct: 1093 GGHEELVQTLLERGASIEHRDK--KGFTPLILAATAGHV--GVVEIL--LDNGADIEAQS 1146
Query: 466 --TKFESNVCVCDFSI-ELSQAMLERSA-QSHSLLKMASPSPCTSSFDKGTMRRMALSMI 521
TK C E+ + +L R A + H + +P LS+
Sbjct: 1147 ERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTP----------------LSLA 1190
Query: 522 ERRKRWRTIKLLLRRGADPNLCC---VPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPP 578
IK+LL GA+ N + + L LA G V+LLL+ G+ DI
Sbjct: 1191 ASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGS--DINAQI 1248
Query: 579 QLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSN 638
+ + T L +A + ++V LLL +V+ +A K G L+ ++
Sbjct: 1249 ETNRNTALTLACF---QGRTEVVSLLLDRKANVEHRA-------KTGLTPLMEAASGGYA 1298
Query: 639 EPGPPQAYYSTDTALPE--EGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLL-WSG 695
E G D P TAL +A ++ C LL+ GA+ ++ G
Sbjct: 1299 EVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFC-----ELLIGRGAHIDVRNKKG 1353
Query: 696 HSPLSLSIASGNELVVKELLTQGAD 720
++PL L+ G+ VV+ L+ GAD
Sbjct: 1354 NTPLWLAANGGHLDVVQLLVQAGAD 1378
Score = 36.6 bits (83), Expect = 0.11
Identities = 57/223 (25%), Positives = 87/223 (39%), Gaps = 41/223 (18%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDIC---FPPQLSTLTPLHIAAALPGEEGVQIVELLLH 606
L A AG V+ RLLLE+GA + F TL A G +++V LL
Sbjct: 371 LMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTL------ACYKGH--LEMVRFLLE 422
Query: 607 AITDVDAKASDED----DTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTAL 662
A D + K + + G +++ L + P + + L GG
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV-- 480
Query: 663 HMACEREDDNKCARDIVRLLLSHGAN-PNLLWSGHSPLSLSIASGNELVVKELLTQGADP 721
++ LL+ GA+ + G++PL + G+E +V LL QGA+
Sbjct: 481 --------------ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANI 526
Query: 722 NLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
N + +AL +AC L + D LI GADI
Sbjct: 527 NAQTEETQETALTLAC---------CGGFLEVADFLIKAGADI 560
Score = 35.4 bits (80), Expect = 0.25
Identities = 23/71 (32%), Positives = 36/71 (50%), Gaps = 1/71 (1%)
Query: 260 SMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADV 319
S ++ A+EG+ E + +L A+ A G T L A + H D+ ++LL GAD+
Sbjct: 565 STPLMEAAQEGHLELVKYLLAAG-ANVHATTATGDTALTYACENGHTDVADVLLQAGADL 623
Query: 320 NKCSDEGLTAL 330
S+ G T L
Sbjct: 624 EHESEGGRTPL 634
Score = 34.7 bits (78), Expect = 0.43
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 647 YSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGAN-PNLLWSGHSPLSLSIAS 705
+ D G TAL AC D+V++LL GA+ + +GH+PL + ++
Sbjct: 323 HKADVNAQSSTGNTALTYACAGG-----YVDVVKVLLESGASIEDHNENGHTPLMEAGSA 377
Query: 706 GNELVVKELLTQGADPNLPLTKGLGSALCVAC 737
G+ V + LL GA N + SAL +AC
Sbjct: 378 GHVEVARLLLENGAGINTHSNEFKESALTLAC 409
Score = 34.3 bits (77), Expect = 0.56
Identities = 33/116 (28%), Positives = 48/116 (41%), Gaps = 16/116 (13%)
Query: 264 ILKAEEGNHEWICRILKDNFASADVADAKG-YTVLAAAATHCHNDIVNLLLDCGADVNKC 322
++KA H + L A+ + A +TVL+ A H +V LLL GAD
Sbjct: 634 LMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHR 693
Query: 323 SDEGLTAL----------SMCFLLHYPAQSFK---PNVAERTIP--EPQEPPKFPV 363
+G T L +C+LL YP P+V + T P + P+ PV
Sbjct: 694 LKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPV 749
Score = 31.6 bits (70), Expect = 3.6
Identities = 27/87 (31%), Positives = 42/87 (48%), Gaps = 6/87 (6%)
Query: 652 ALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGAN-PNLLWSGHSPLSLSIASGNELV 710
A E TAL +AC + ++V+ LL GA+ + G +PL L+ +G+ V
Sbjct: 1077 AQTESNHDTALTLACAGGHE-----ELVQTLLERGASIEHRDKKGFTPLILAATAGHVGV 1131
Query: 711 VKELLTQGADPNLPLTKGLGSALCVAC 737
V+ LL GAD + + L +AC
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLAC 1158
>gi|13376267 MORN repeat containing 1 [Homo sapiens]
Length = 497
Score = 54.3 bits (129), Expect = 5e-07
Identities = 34/125 (27%), Positives = 52/125 (41%), Gaps = 25/125 (20%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWP-DGSSFTGTFYLSHREGY 60
Y+GE+ K G+GK + G Y G F G G W G +F+G F L +GY
Sbjct: 39 YEGEWKAGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWSGDTFSGQFVLGEPQGY 98
Query: 61 GTMYMKT------------------------RLFQGLYKADQRFGPGVETYPDGSQDVGL 96
G M K +++QG + ++R GPG + +G + G
Sbjct: 99 GVMEYKAGGCYEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGD 158
Query: 97 WFREQ 101
W R++
Sbjct: 159 WVRDR 163
Score = 48.1 bits (113), Expect = 4e-05
Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 1/109 (0%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Y+GE M+ G+G G+ Y G F+ + HG G ++ +G + G + R+G+G
Sbjct: 109 YEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGDWVRDRRQGHG 168
Query: 62 TMYMKT-RLFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQI 109
+ ++G + +D G G + G GLW + T+I
Sbjct: 169 VLRCADGSTYKGQWHSDVFSGLGSMAHCSGVTYYGLWINGHPAEQATRI 217
Score = 47.8 bits (112), Expect = 5e-05
Identities = 30/97 (30%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
+ G+F L GYG + G Y G+ G G + DG + G+F+ + R G G
Sbjct: 86 FSGQFVLGEPQGYGVMEYKAGGCYEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPG 145
Query: 62 TM-YMKTRLFQGLYKADQRFGPGVETYPDGSQDVGLW 97
M + + G + D+R G GV DGS G W
Sbjct: 146 QMLFQNGDKYDGDWVRDRRQGHGVLRCADGSTYKGQW 182
Score = 42.7 bits (99), Expect = 0.002
Identities = 21/63 (33%), Positives = 32/63 (50%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
+YQG F N + G G+ + G+ Y G + RD G G DGS++ G ++ G
Sbjct: 131 VYQGSFHDNKRHGPGQMLFQNGDKYDGDWVRDRRQGHGVLRCADGSTYKGQWHSDVFSGL 190
Query: 61 GTM 63
G+M
Sbjct: 191 GSM 193
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 53.1 bits (126), Expect = 1e-06
Identities = 61/199 (30%), Positives = 81/199 (40%), Gaps = 20/199 (10%)
Query: 532 LLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAA 590
LLL GAD N L A + GD RLLL+HGA D + TPLH+AA
Sbjct: 413 LLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDA---QEREGWTPLHLAA 469
Query: 591 ALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTD 650
E + LL+ D + ++ S +KL G +
Sbjct: 470 QNNFEN---VARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG-------AE 519
Query: 651 TALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGNEL 709
+ RT LH+A ER ++ LL GA P+ L SG+ PL + A G L
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRA-----IQHLLKSGAVPDALDQSGYGPLHTAAARGKYL 574
Query: 710 VVKELLTQGADPNLPLTKG 728
+ K LL GA LP +G
Sbjct: 575 ICKMLLRYGASLELPTHQG 593
Score = 52.4 bits (124), Expect = 2e-06
Identities = 65/202 (32%), Positives = 86/202 (42%), Gaps = 36/202 (17%)
Query: 531 KLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIA 589
+LL+ R ADPNL + L +A G V V+LL GA D Q + TPLH+A
Sbjct: 478 RLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDA---QQRNLRTPLHLA 534
Query: 590 AALPGEEG-VQIVELLLHAITDVDAKASDEDDTYKP-------GKLDLLPSSLKLSNEPG 641
E G V+ ++ LL + DA + Y P GK + L+
Sbjct: 535 V----ERGKVRAIQHLLKSGAVPDAL---DQSGYGPLHTAAARGKYLICKMLLR------ 581
Query: 642 PPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGH-SPLS 700
Y LP G T LH+A K +I+ LL AN L + + +PL
Sbjct: 582 -----YGASLELPTHQGWTPLHLAAY-----KGHLEIIHLLAESHANMGALGAVNWTPLH 631
Query: 701 LSIASGNELVVKELLTQGADPN 722
L+ G E VV LL GADPN
Sbjct: 632 LAARHGEEAVVSALLQCGADPN 653
Score = 40.4 bits (93), Expect = 0.008
Identities = 34/104 (32%), Positives = 47/104 (45%), Gaps = 4/104 (3%)
Query: 232 PAHTSWNMGAILEGK---RSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASADV 288
P HT+ G L K R G + P Q + L A +G+ E I +L ++ A+
Sbjct: 563 PLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE-IIHLLAESHANMGA 621
Query: 289 ADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 332
A +T L AA H +V+ LL CGAD N G T L +
Sbjct: 622 LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHL 665
Score = 39.3 bits (90), Expect = 0.017
Identities = 74/298 (24%), Positives = 104/298 (34%), Gaps = 79/298 (26%)
Query: 509 DKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCVPMQV--LFLAVKAGDVDGVRLLL 566
D G + AL + +R+ L+ R D LC +V L V G V+ VRLLL
Sbjct: 332 DSGNYLKRALQLSDRKN-------LVPR--DEELCIYENKVTPLHFLVAQGSVEQVRLLL 382
Query: 567 EHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK 626
H D S TPL IAA ++ + LLL DA DED
Sbjct: 383 AHEVDVDC---QTASGYTPLLIAAQ---DQQPDLCALLL--AHGADANRVDEDGW----- 429
Query: 627 LDLLPSSLKLSN-EPGPPQAYYSTDTALP--EEGGRTALHMACEREDDNKCARDIVRLLL 683
P N + G + + E G T LH+A + +N + RLL+
Sbjct: 430 ---APLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFEN-----VARLLV 481
Query: 684 SHGANPNL------------LWSGH----------------------SPLSLSIASGNEL 709
S A+PNL + GH +PL L++ G
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 710 VVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKP 767
++ LL GA P+ G G H K + L+ +GA + P
Sbjct: 542 AIQHLLKSGAVPDALDQSGYGPL----------HTAAARGKYLICKMLLRYGASLELP 589
Score = 35.4 bits (80), Expect = 0.25
Identities = 23/66 (34%), Positives = 31/66 (46%), Gaps = 6/66 (9%)
Query: 277 RILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLL 336
R+L + D A GYT L AA D+ LLL GAD N+ ++G L
Sbjct: 379 RLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAP------L 432
Query: 337 HYPAQS 342
H+ AQ+
Sbjct: 433 HFAAQN 438
Score = 33.1 bits (74), Expect = 1.2
Identities = 20/64 (31%), Positives = 31/64 (48%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A + + R+L D+ A D + +G+T L AA + ++ LL+ AD N EG
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEG 494
Query: 327 LTAL 330
T L
Sbjct: 495 KTPL 498
Score = 31.6 bits (70), Expect = 3.6
Identities = 18/54 (33%), Positives = 29/54 (53%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVN 320
A + N E + R+L A ++ +A+G T L AA H +V LL GA+++
Sbjct: 468 AAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELD 521
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 52.4 bits (124), Expect = 2e-06
Identities = 67/247 (27%), Positives = 107/247 (43%), Gaps = 52/247 (21%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L +A GD + + LL+ GAR + LTPLH A A EE VQ+ L+ H+
Sbjct: 20 LHVAAFLGDAEIIELLILSGARVNA---KDNMWLTPLHRAVASRSEEAVQV--LIKHS-A 73
Query: 610 DVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACERE 669
DV+A+ + + P + ++K + P + + + GGRTALH A
Sbjct: 74 DVNAR---DKNWQTPLHVAAANKAVKCAEVIIP----LLSSVNVSDRGGRTALHHAALNG 126
Query: 670 D-----------------DNKCAR-----------DIVRLLLSHGANPNLL-WSGHSPLS 700
D K R D+V LL++HGA G++PL
Sbjct: 127 HVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLH 186
Query: 701 LSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISH 760
+ ++G VVK LL G + + G +AL +AC + + A+++ LI +
Sbjct: 187 AAASNGQINVVKHLLNLGVEIDEINVYG-NTALHIAC---------YNGQDAVVNELIDY 236
Query: 761 GADILKP 767
GA++ +P
Sbjct: 237 GANVNQP 243
Score = 39.7 bits (91), Expect = 0.013
Identities = 30/79 (37%), Positives = 41/79 (51%), Gaps = 4/79 (5%)
Query: 256 KEQLSMEMILKAEEGNHEWIC-RIL---KDNFASADVADAKGYTVLAAAATHCHNDIVNL 311
K+ ++ L A N +C R+L DN + DV DAKG T L A + H D V+L
Sbjct: 604 KDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSL 663
Query: 312 LLDCGADVNKCSDEGLTAL 330
LL+ A+V+ G TAL
Sbjct: 664 LLEKEANVDTVDILGCTAL 682
Score = 39.3 bits (90), Expect = 0.017
Identities = 29/76 (38%), Positives = 38/76 (50%), Gaps = 7/76 (9%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A GN E I ++L+ + A D G T L AA +CH + L+ GA+VN+ D G
Sbjct: 388 AAGGNVECI-KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWG 446
Query: 327 LTALSMCFLLHYPAQS 342
TA LHY A S
Sbjct: 447 RTA------LHYAAAS 456
Score = 37.7 bits (86), Expect = 0.051
Identities = 56/226 (24%), Positives = 86/226 (38%), Gaps = 52/226 (23%)
Query: 530 IKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 588
+ LLL +GA+ N + L A G +D V LL+ HGA TPLH
Sbjct: 131 VNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC---KDKKGYTPLH- 186
Query: 589 AAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYS 648
AAA G+ + +V+ LL+ ++D E + Y G L + + Y
Sbjct: 187 AAASNGQ--INVVKHLLNLGVEID-----EINVY--GNTALHIACYNGQDAVVNELIDYG 237
Query: 649 TDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWS-------------- 694
+ P G T LH A C + LL+++GA+ N+
Sbjct: 238 ANVNQPNNNGFTPLHFAAASTHGALC----LELLVNNGADVNIQSKDGKSPLHMTAVHGR 293
Query: 695 --------------------GHSPLSLSIASGNELVVKELLTQGAD 720
G++PL ++ G+EL++ L T GAD
Sbjct: 294 FTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGAD 339
Score = 35.8 bits (81), Expect = 0.19
Identities = 26/85 (30%), Positives = 44/85 (51%), Gaps = 10/85 (11%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALS 331
H + +L ++ A D KGYT L AAA++ ++V LL+ G ++++ + G TAL
Sbjct: 160 HLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALH 219
Query: 332 M-CF---------LLHYPAQSFKPN 346
+ C+ L+ Y A +PN
Sbjct: 220 IACYNGQDAVVNELIDYGANVNQPN 244
Score = 35.0 bits (79), Expect = 0.33
Identities = 113/502 (22%), Positives = 179/502 (35%), Gaps = 57/502 (11%)
Query: 230 NKPAHTSWNMGA-----ILEGKRSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFA 284
N P H + G L + A CG + + A H CR L +
Sbjct: 315 NTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHL---AALNAHSDCCRKLLSSGF 371
Query: 285 SADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSFK 344
D D G T L AAA + + + LL GAD +K G T LHY A +
Sbjct: 372 EIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP------LHYAAANCH 425
Query: 345 PNVAERTIPEPQEPPKF-----PVVPILSSSFMDTNLESL--YYEVNVPSQGSYELRPPP 397
+ E + + + ++S MD N L ++ + + + EL+
Sbjct: 426 FHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKE 485
Query: 398 APLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPLVKGSLGHVESGLEDVLGNTD 457
A L L + + +D + G + H +++ G ++ L SG E+
Sbjct: 486 ATLCLEFLLQNDANPSIRD--KEGYNSIHYAAAY-GHRQCLELLLERTNSGFEESDSGAT 542
Query: 458 RGSLCSA---------ETKFESNVCVCDFSIELSQAMLERSA-QSHSLLKMASPSPCTSS 507
+ L A E +S V + D E + L+ +A + H+ A +P S
Sbjct: 543 KSPLHLAAYNGHHQALEVLLQSLVDL-DIRDEKGRTALDLAAFKGHTECVEALINPGASI 601
Query: 508 FDKGTM-RRMALSMIERRKRWRTIKLLLRRGADPNLCCVP----MQVLFLAVKAGDVDGV 562
F K + +R L ++LLL +P V L LAV G +D V
Sbjct: 602 FVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAV 661
Query: 563 RLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKA-SDEDDT 621
LLLE A D + T LH EE VQ++ +I D++ +
Sbjct: 662 SLLLEKEANVDTV---DILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718
Query: 622 YKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRL 681
G L L++ A D + G T LH AC ++N + +
Sbjct: 719 AARGHATWLSELLQM--------ALSEEDCCFKDNQGYTPLHWACYNGNEN-----CIEV 765
Query: 682 LLSHGANPNLLWSGHSPLSLSI 703
LL + + +PL +I
Sbjct: 766 LLEQKCFRKFIGNPFTPLHCAI 787
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/47 (40%), Positives = 28/47 (59%)
Query: 284 ASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+S +V+D G T L AA + H ++VNLLL GA++N + AL
Sbjct: 106 SSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRAL 152
Score = 32.3 bits (72), Expect = 2.1
Identities = 19/57 (33%), Positives = 24/57 (42%)
Query: 279 LKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFL 335
L N D D G T L AA + H ++N L GAD KC + L + L
Sbjct: 300 LIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
Score = 32.0 bits (71), Expect = 2.8
Identities = 20/43 (46%), Positives = 23/43 (53%)
Query: 290 DAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 332
D KG T L AAA H + + LLL A VN + G TAL M
Sbjct: 811 DDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMM 853
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 51.6 bits (122), Expect = 3e-06
Identities = 113/509 (22%), Positives = 178/509 (34%), Gaps = 119/509 (23%)
Query: 262 EMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNK 321
E++ A GN E + +L + +D + T L AA + IV LLL GADV+
Sbjct: 180 ELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHA 239
Query: 322 CSDEGLTAL-SMCFLLHYPAQSF--KPNVAERTIPEPQEPP--------KFPVVPILSSS 370
L L + C HY K + Q P + V +L S
Sbjct: 240 KDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSY 299
Query: 371 FMDTNLESLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSS 430
D L +N ++ + +L P P L R++ +G + + +
Sbjct: 300 GADPTL------LNCHNKSAIDLAPTPQ--LKERLAYEFKGHSLLQAAR-----EADVTR 346
Query: 431 LKGDSPLVKGSLGHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSA 490
+K L + H ++ + C+A + + +C+ + + E++
Sbjct: 347 IKKHLSLEMVNFKHPQTH--------ETALHCAAASPYPKRKQICELLLRKGANINEKTK 398
Query: 491 QSHSLLKMASPSPCTSSFD---KGTMRRMALSMIERRKRWR--------TIKLLLRRGAD 539
+ + L +AS + K + AL + + R T +LLL G D
Sbjct: 399 EFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCD 458
Query: 540 PNLCCVP------------MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTL---- 583
PN+ + Q+L + G+ + R LLE D+ +L T+
Sbjct: 459 PNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVN 518
Query: 584 ---------TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSL 634
TPLH AA G V +VE LL DV AK
Sbjct: 519 CRDIEGRQSTPLHFAA---GYNRVSVVEYLLQHGADVHAK-------------------- 555
Query: 635 KLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNL--L 692
++GG LH AC ++ LL+ HGA N+ L
Sbjct: 556 --------------------DKGGLVPLHNACSYGH-----YEVAELLVKHGAVVNVADL 590
Query: 693 WSGHSPLSLSIASGNELVVKELLTQGADP 721
W +PL + A G + K LL GADP
Sbjct: 591 WK-FTPLHEAAAKGKYEICKLLLQHGADP 618
Score = 44.7 bits (104), Expect = 4e-04
Identities = 67/278 (24%), Positives = 108/278 (38%), Gaps = 49/278 (17%)
Query: 524 RKRWRTIKLLLRRGADPNLC-CVPMQVLFLA------------------VKAGDVDGVRL 564
+ R LLL GADP L C + LA ++A V
Sbjct: 287 KNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTR 346
Query: 565 LLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKP 624
+ +H + + F + T LH AAA P + QI ELLL K ++ ++ K
Sbjct: 347 IKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLR-------KGANINEKTKE 399
Query: 625 GKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLS 684
L +S K N+ + + G+T+LH A C RLLLS
Sbjct: 400 FLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTC-----RLLLS 454
Query: 685 HGANPNLL-WSGHSPLSL-----------SIASGNELVVKELLTQGADPNLPLTKGLGSA 732
+G +PN++ G + L + I+ GN ++LL ++ K L +
Sbjct: 455 YGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTV 514
Query: 733 LCVAC------DLTYEHQRNMDSKLALIDRLISHGADI 764
V C T H +++++++ L+ HGAD+
Sbjct: 515 QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV 552
Score = 43.5 bits (101), Expect = 0.001
Identities = 60/217 (27%), Positives = 82/217 (37%), Gaps = 39/217 (17%)
Query: 526 RWRTIKLLLRRGADPNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDI----------- 574
++ KLLL+ GADP VK GD D LL A D
Sbjct: 604 KYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKK 663
Query: 575 --------CFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGK 626
C Q TPLH+AA G +++ E LL DV+A+ K G
Sbjct: 664 LSSPDNVNCRDTQGRHSTPLHLAA---GYNNLEVAEYLLQHGADVNAQD-------KGGL 713
Query: 627 LDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHG 686
+ L ++ + Y+ ++ T LH A ++ CA LLL+HG
Sbjct: 714 IPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCA-----LLLAHG 768
Query: 687 ANPNLL-WSGHSPLSLSIASGNELVVKELLTQGADPN 722
A+P L G +PL L A V LLT P+
Sbjct: 769 ADPTLKNQEGQTPLDLVSADD----VSALLTAAMPPS 801
Score = 38.1 bits (87), Expect = 0.039
Identities = 27/76 (35%), Positives = 38/76 (50%), Gaps = 8/76 (10%)
Query: 655 EEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLL--WSGHSPLSLSIASGNELVVK 712
++GG LH AC ++V LLL HGA+PN W+ ++PL + G V
Sbjct: 88 DDGGLIPLHNACSFGH-----AEVVNLLLRHGADPNARDNWN-YTPLHEAAIKGKIDVCI 141
Query: 713 ELLTQGADPNLPLTKG 728
LL GA+P + T G
Sbjct: 142 VLLQHGAEPTIRNTDG 157
Score = 32.0 bits (71), Expect = 2.8
Identities = 28/106 (26%), Positives = 47/106 (44%), Gaps = 2/106 (1%)
Query: 229 RNKPAH--TSWNMGAILEGKRSGFAPCGPKEQLSMEMILKAEEGNHEWICRILKDNFASA 286
++ P H +N +++E A K++ + + A H + +L + A
Sbjct: 526 QSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV 585
Query: 287 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 332
+VAD +T L AA +I LLL GAD K + +G T L +
Sbjct: 586 NVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDL 631
Score = 30.8 bits (68), Expect = 6.2
Identities = 24/90 (26%), Positives = 38/90 (42%), Gaps = 15/90 (16%)
Query: 256 KEQLSMEMILKAEEGNHEW---------------ICRILKDNFASADVADAKGYTVLAAA 300
K+ LS+EM+ HE IC +L A+ + + T L A
Sbjct: 348 KKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVA 407
Query: 301 ATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ HND+V +++ A VN + G T+L
Sbjct: 408 SEKAHNDVVEVVVKHEAKVNALDNLGQTSL 437
>gi|24586688 ankyrin repeat and SOCS box-containing protein 16 [Homo
sapiens]
Length = 453
Score = 50.8 bits (120), Expect = 6e-06
Identities = 64/243 (26%), Positives = 99/243 (40%), Gaps = 19/243 (7%)
Query: 533 LLRRGADPNLCCVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAAL 592
L+R+GA+ + L A D VRLLL GA+ ++ TPLH+
Sbjct: 130 LIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTE---EGTTPLHLCTI- 185
Query: 593 PGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTA 652
E +Q +LLL A V+ A + +T L ++ + + + D
Sbjct: 186 --PESLQCAKLLLEAGATVNLAAGESQET------PLHVAAARGLEQHVALYLEHGADVG 237
Query: 653 LPEEGGRTALHMACE-REDDNKCARD--IVRLLLSHGANPNLLW-SGHSPLSLSIASGNE 708
L G TAL+ AC E C R R LL GA+ H+PL + A+G
Sbjct: 238 LRTSQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCG 297
Query: 709 LVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILKPV 768
+ + LL GA +P G G + N + ++ L L+ +GA ++P
Sbjct: 298 GLAELLLRYGARAEVP--NGAGHTPMDCALQAVQDSPNWEPEV-LFAALLDYGAQPVRPE 354
Query: 769 MLR 771
ML+
Sbjct: 355 MLK 357
Score = 32.7 bits (73), Expect = 1.6
Identities = 27/98 (27%), Positives = 37/98 (37%), Gaps = 23/98 (23%)
Query: 257 EQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYT--------------------- 295
E +S ++ AE+G W+ A +A A+GYT
Sbjct: 88 ETVSNQLAWSAEQGF--WVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVGGRA 145
Query: 296 VLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMC 333
L A D V LLL GA N ++EG T L +C
Sbjct: 146 ALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLC 183
>gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens]
Length = 870
Score = 50.4 bits (119), Expect = 8e-06
Identities = 40/160 (25%), Positives = 65/160 (40%), Gaps = 20/160 (12%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Y+G F + G G + W G Y G F ++ G Y WPDGS + G R G+G
Sbjct: 109 YRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFG 168
Query: 62 TMYMKTR--LFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQIPSGFSLLRYP 119
T+ + G + +R G G Y +Q+ W+ ++ I G+ + Y
Sbjct: 169 MFKCSTQPVSYIGHWCNGKRHGKGSIYY---NQEGTCWYEGDWVQ---NIKKGWGIRCYK 222
Query: 120 -------EFSSFITHSPAR---ISLSEEEKTEW--GLQEG 147
++ + H R ++ +EE W G+Q G
Sbjct: 223 SGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNG 262
Score = 47.0 bits (110), Expect = 8e-05
Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 12/102 (11%)
Query: 1 MYQGEFGLNMKLGYGKFSW-PTGESYHGQFYRDHCHGLGTYMW----------PDGSSFT 49
+Y+G++ NM+ G G+ W T E Y G++ R +G GT+ W P + +
Sbjct: 226 IYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYI 285
Query: 50 GTFYLSHREGYGTMYMKT-RLFQGLYKADQRFGPGVETYPDG 90
G F +R G G Y + ++ G + ++++ G G T+ +G
Sbjct: 286 GEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNG 327
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/59 (32%), Positives = 30/59 (50%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
Y GEF + G GKF + +G Y G++ + HG+G + +G + G F H G+
Sbjct: 284 YIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 342
Score = 40.0 bits (92), Expect = 0.010
Identities = 19/51 (37%), Positives = 26/51 (50%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 52
Y+GE + G G ++ G +Y G F HG GTY+W DG + G F
Sbjct: 86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDF 136
Score = 39.7 bits (91), Expect = 0.013
Identities = 21/91 (23%), Positives = 40/91 (43%), Gaps = 11/91 (12%)
Query: 2 YQGEFGLNMKLGYGKFSW----------PTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 51
Y G + ++ G+G +W P Y G+F + HG G + + G+ + G
Sbjct: 251 YTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGE 310
Query: 52 FYLSHREGYGTMYMKT-RLFQGLYKADQRFG 81
+ + + G G + K R+++G + D G
Sbjct: 311 WVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 341
Score = 35.0 bits (79), Expect = 0.33
Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGE-SYHGQFYRDHCHGLGT-YMWPDGSS-FTGTFYLSHR 57
MY+GE M+ G+G F T SY G + HG G+ Y +G+ + G + + +
Sbjct: 154 MYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIK 213
Query: 58 EGYG-TMYMKTRLFQGLYKADQRFGPG 83
+G+G Y +++G ++ + R G G
Sbjct: 214 KGWGIRCYKSGNIYEGQWEDNMRHGEG 240
Score = 34.3 bits (77), Expect = 0.56
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHG 36
MY GE+ N K G G+ ++ G Y G F DH G
Sbjct: 306 MYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 341
Score = 33.1 bits (74), Expect = 1.2
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 23 ESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKTRL-FQGLYKADQRFG 81
ESY G+ R G G + G ++ G F G GT L ++G + +
Sbjct: 84 ESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMN 143
Query: 82 PGVETYPDGSQDVG 95
GV T+PDGS G
Sbjct: 144 HGVYTWPDGSMYEG 157
>gi|149999376 MORN repeat containing 4 [Homo sapiens]
Length = 146
Score = 50.4 bits (119), Expect = 8e-06
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Y+GE+ + G+G+ + G +Y G F +G G + DGS + G F G G
Sbjct: 16 YRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVG 75
Query: 62 TMYMKTRL-FQGLYKADQRFGPGVETYPDGSQDV----GLWFREQLIK 104
+ F+G +K + G G+ T+PDGS + GL+ +L++
Sbjct: 76 VFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNKLLR 123
>gi|30520314 MORN repeat containing 4 [Homo sapiens]
Length = 146
Score = 50.4 bits (119), Expect = 8e-06
Identities = 31/108 (28%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Y+GE+ + G+G+ + G +Y G F +G G + DGS + G F G G
Sbjct: 16 YRGEWKEGRRHGFGQLMFADGGTYLGHFENGLFNGFGVLTFSDGSRYEGEFAQGKFNGVG 75
Query: 62 TMYMKTRL-FQGLYKADQRFGPGVETYPDGSQDV----GLWFREQLIK 104
+ F+G +K + G G+ T+PDGS + GL+ +L++
Sbjct: 76 VFIRYDNMTFEGEFKNGRVDGFGLLTFPDGSHGIPRNEGLFENNKLLR 123
>gi|157502187 radial spoke head 10 homolog B [Homo sapiens]
Length = 870
Score = 50.4 bits (119), Expect = 8e-06
Identities = 40/160 (25%), Positives = 65/160 (40%), Gaps = 20/160 (12%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
Y+G F + G G + W G Y G F ++ G Y WPDGS + G R G+G
Sbjct: 109 YRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFG 168
Query: 62 TMYMKTR--LFQGLYKADQRFGPGVETYPDGSQDVGLWFREQLIKLCTQIPSGFSLLRYP 119
T+ + G + +R G G Y +Q+ W+ ++ I G+ + Y
Sbjct: 169 MFKCSTQPVSYIGHWCNGKRHGKGSIYY---NQEGTCWYEGDWVQ---NIKKGWGIRCYK 222
Query: 120 -------EFSSFITHSPAR---ISLSEEEKTEW--GLQEG 147
++ + H R ++ +EE W G+Q G
Sbjct: 223 SGNIYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNG 262
Score = 47.0 bits (110), Expect = 8e-05
Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 12/102 (11%)
Query: 1 MYQGEFGLNMKLGYGKFSW-PTGESYHGQFYRDHCHGLGTYMW----------PDGSSFT 49
+Y+G++ NM+ G G+ W T E Y G++ R +G GT+ W P + +
Sbjct: 226 IYEGQWEDNMRHGEGRMRWLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYI 285
Query: 50 GTFYLSHREGYGTMYMKT-RLFQGLYKADQRFGPGVETYPDG 90
G F +R G G Y + ++ G + ++++ G G T+ +G
Sbjct: 286 GEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNG 327
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/59 (32%), Positives = 30/59 (50%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGY 60
Y GEF + G GKF + +G Y G++ + HG+G + +G + G F H G+
Sbjct: 284 YIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGF 342
Score = 40.0 bits (92), Expect = 0.010
Identities = 19/51 (37%), Positives = 26/51 (50%)
Query: 2 YQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTF 52
Y+GE + G G ++ G +Y G F HG GTY+W DG + G F
Sbjct: 86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDF 136
Score = 39.7 bits (91), Expect = 0.013
Identities = 21/91 (23%), Positives = 40/91 (43%), Gaps = 11/91 (12%)
Query: 2 YQGEFGLNMKLGYGKFSW----------PTGESYHGQFYRDHCHGLGTYMWPDGSSFTGT 51
Y G + ++ G+G +W P Y G+F + HG G + + G+ + G
Sbjct: 251 YTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGE 310
Query: 52 FYLSHREGYGTMYMKT-RLFQGLYKADQRFG 81
+ + + G G + K R+++G + D G
Sbjct: 311 WVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 341
Score = 35.0 bits (79), Expect = 0.33
Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGE-SYHGQFYRDHCHGLGT-YMWPDGSS-FTGTFYLSHR 57
MY+GE M+ G+G F T SY G + HG G+ Y +G+ + G + + +
Sbjct: 154 MYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWVQNIK 213
Query: 58 EGYG-TMYMKTRLFQGLYKADQRFGPG 83
+G+G Y +++G ++ + R G G
Sbjct: 214 KGWGIRCYKSGNIYEGQWEDNMRHGEG 240
Score = 34.3 bits (77), Expect = 0.56
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHG 36
MY GE+ N K G G+ ++ G Y G F DH G
Sbjct: 306 MYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAG 341
Score = 33.1 bits (74), Expect = 1.2
Identities = 23/74 (31%), Positives = 32/74 (43%), Gaps = 1/74 (1%)
Query: 23 ESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYGTMYMKTRL-FQGLYKADQRFG 81
ESY G+ R G G + G ++ G F G GT L ++G + +
Sbjct: 84 ESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMN 143
Query: 82 PGVETYPDGSQDVG 95
GV T+PDGS G
Sbjct: 144 HGVYTWPDGSMYEG 157
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 50.1 bits (118), Expect = 1e-05
Identities = 64/217 (29%), Positives = 91/217 (41%), Gaps = 43/217 (19%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L A GD + + LL+ GAR + LTPLH A A EE VQ+ LL H+
Sbjct: 45 LHAAAYLGDAEIIELLILSGARVNA---KDSKWLTPLHRAVASCSEEAVQV--LLKHS-A 98
Query: 610 DVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACERE 669
DV+A+ + + P + ++K + P ++ + + GRTALH A
Sbjct: 99 DVNAR---DKNWQTPLHIAAANKAVKCAEALVP----LLSNVNVSDRAGRTALHHAAFSG 151
Query: 670 D-----------------DNKCAR-----------DIVRLLLSHGANPNLL-WSGHSPLS 700
D K R ++V+LL+SHGA ++PL
Sbjct: 152 HGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLH 211
Query: 701 LSIASGNELVVKELLTQGADPNLPLTKGLGSALCVAC 737
+ +SG VVK LL G D N P G + L VAC
Sbjct: 212 AAASSGMISVVKYLLDLGVDMNEPNAYG-NTPLHVAC 247
Score = 42.7 bits (99), Expect = 0.002
Identities = 60/215 (27%), Positives = 92/215 (42%), Gaps = 27/215 (12%)
Query: 550 LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAIT 609
L A+ GD D VR L+ + D+ F TPLH AA L E I+ELL+ +
Sbjct: 12 LVQAIFNGDPDEVRALIFK--KEDVNFQDN-EKRTPLHAAAYLGDAE---IIELLILSGA 65
Query: 610 DVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYSTDTALPEEGGRTALHMACERE 669
V+AK S L + S E +S D ++ +T LH+A +
Sbjct: 66 RVNAKDS-------KWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANK 118
Query: 670 DDNKCARDIVRLLLSHGANPNLLWSGHSPLSLSIASGNELVVKELLTQGADPNLPLTKGL 729
KCA +V LL + + +G + L + SG+ +VK LL++GA+ N K
Sbjct: 119 -AVKCAEALVPLLSNVNVSDR---AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKK-- 172
Query: 730 GSALCVACDLTYEHQRNMDSKLALIDRLISHGADI 764
D H + ++ L+SHGA++
Sbjct: 173 --------DRRAIHWAAYMGHIEVVKLLVSHGAEV 199
Score = 40.4 bits (93), Expect = 0.008
Identities = 63/259 (24%), Positives = 94/259 (36%), Gaps = 55/259 (21%)
Query: 530 IKLLLRRGADPNLCCVP-MQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 588
+KLLL RGA+ N + + A G ++ V+LL+ HGA + TPLH
Sbjct: 156 VKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTC---KDKKSYTPLHA 212
Query: 589 AAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAYYS 648
AA+ G + ++ L L + P AY
Sbjct: 213 AAS--------------------------------SGMISVVKYLLDLGVDMNEPNAY-- 238
Query: 649 TDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIASGN 707
G T LH+AC D +V L+ GA N G +PL + AS +
Sbjct: 239 ---------GNTPLHVACYNGQD-----VVVNELIDCGAIVNQKNEKGFTPLHFAAASTH 284
Query: 708 ELVVKELLT-QGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADILK 766
+ ELL GAD N+ G A + + + A+ID +G L
Sbjct: 285 GALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLH 344
Query: 767 PVMLRQGEKEAVGTAVDYG 785
+ R G + + T + G
Sbjct: 345 -IAARYGHELLINTLITSG 362
Score = 36.2 bits (82), Expect = 0.15
Identities = 40/141 (28%), Positives = 67/141 (47%), Gaps = 20/141 (14%)
Query: 584 TPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLK-LSNEPGP 642
TPLH AA E +Q+ LL H +A+ + D T GK L+ ++ +N
Sbjct: 825 TPLHAAAFTDHVECLQL--LLSH-----NAQVNSVDST---GKTPLMMAAENGQTNTVEM 874
Query: 643 PQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSGHS----P 698
+ S + L + TALH+AC + + L+L + NL+ + ++ P
Sbjct: 875 LVSSASAELTLQDNSKNTALHLACSKGHETSAL-----LILEKITDRNLINATNAALQTP 929
Query: 699 LSLSIASGNELVVKELLTQGA 719
L ++ +G +VV+ELL +GA
Sbjct: 930 LHVAARNGLTMVVQELLGKGA 950
Score = 35.4 bits (80), Expect = 0.25
Identities = 121/525 (23%), Positives = 195/525 (37%), Gaps = 83/525 (15%)
Query: 267 AEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEG 326
A GN E + +L + A + D G + L AA +C+ + L+ GA VN + G
Sbjct: 413 AAGGNLECL-NLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERG 471
Query: 327 LTALSMCFLLHYPAQSFKPNVAERTIPEPQEPPKFPVVPI---------LSSSFMDTNLE 377
T L + + + P ++ + V L +T L+
Sbjct: 472 CTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLD 531
Query: 378 SLYYEVNVPSQGSYELRPPPAPLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL 437
L + R +PL L G H+ + Q +D R+SS G +PL
Sbjct: 532 VLMETSGTDMLSDSDNRATISPLHLAAYHGHHQA--LEVLVQSLLDLDVRNSS--GRTPL 587
Query: 438 VKGSL-GHVESGLEDVLGNTDRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHS-- 494
+ GHVE DVL N +++ V D+ ++ + + + HS
Sbjct: 588 DLAAFKGHVEC--VDVLINQG------------ASILVKDYILKRTP-IHAAATNGHSEC 632
Query: 495 ---LLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADPNLCCV-PMQVL 550
L+ A P D + LS++ + LL +GA+ + L
Sbjct: 633 LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD--CVYSLLNKGANVDAKDKWGRTAL 690
Query: 551 FLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITD 610
G + V LL+HGA+ C TP+H++AA G GV + LL +
Sbjct: 691 HRGAVTGHEECVDALLQHGAK---CLLRDSRGRTPIHLSAAC-GHIGV--LGALLQSAAS 744
Query: 611 VDAKASDEDD---------TYKPGK--LDLLPSS----------------LKLSNEPGPP 643
+DA + D+ Y + ++LL +++ G
Sbjct: 745 MDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAA 804
Query: 644 QAYYSTDTA----LPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWS-GHSP 698
+ T A + GRT LH A D +C ++LLLSH A N + S G +P
Sbjct: 805 EMLIDTLGASIVNATDSKGRTPLHAAAFT-DHVEC----LQLLLSHNAQVNSVDSTGKTP 859
Query: 699 LSLSIASGNELVVKELLTQGADPNLPL-TKGLGSALCVACDLTYE 742
L ++ +G V E+L A L L +AL +AC +E
Sbjct: 860 LMMAAENGQTNTV-EMLVSSASAELTLQDNSKNTALHLACSKGHE 903
Score = 35.0 bits (79), Expect = 0.33
Identities = 100/443 (22%), Positives = 171/443 (38%), Gaps = 55/443 (12%)
Query: 284 ASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPAQSF 343
++ +V+D G T L AA H ++V LLL GA++N + A +H+ A
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRA------IHWAAYMG 184
Query: 344 KPNVAERTIPEPQE------PPKFPVVPILSSSFMDTNLESLYYEVNVPSQGSYELRPPP 397
V + + E P+ SS + L V++ +Y
Sbjct: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY----GN 240
Query: 398 APLLLPRVSGSHEGGHFQDTGQCGGSIDHRSSSLKGDSPL-VKGSLGHVESGLEDVLGNT 456
PL + +G + + CG ++ ++ KG +PL + H LE ++GN
Sbjct: 241 TPLHVACYNG--QDVVVNELIDCGAIVNQKNE--KGFTPLHFAAASTHGALCLELLVGNG 296
Query: 457 DRGSLCSAETKFESNVCVCDFSIELSQAMLERSAQSHSLLKMASPSPCTSSFDKGTMRRM 516
++ S + K ++ A+ R ++S ++++ + C DK
Sbjct: 297 ADVNMKSKDGKTPLHM----------TALHGRFSRSQTIIQSGAVIDCE---DKN--GNT 341
Query: 517 ALSMIERRKRWRTIKLLLRRGADPNLCCV-PMQVLFLAVKAGDVDGVRLLLEHGARTDIC 575
L + R I L+ GAD + M L LA +G D R LL G D
Sbjct: 342 PLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID-- 399
Query: 576 FPPQLSTLTPLHIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLK 635
P T LH AAA ++ + LLL+ D + K K G+ L ++
Sbjct: 400 -TPDDFGRTCLHAAAA---GGNLECLNLLLNTGADFNKKD-------KFGRSPLHYAAAN 448
Query: 636 LSNEPGPPQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLL-WS 694
+ + +E G T LH A + D KC + LL + ANP +
Sbjct: 449 CNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKC----LEYLLRNDANPGIRDKQ 504
Query: 695 GHSPLSLSIASGNELVVKELLTQ 717
G++ + S A G+ L ++ + ++
Sbjct: 505 GYNAVHYSAAYGHRLCLQLIASE 527
Score = 35.0 bits (79), Expect = 0.33
Identities = 21/59 (35%), Positives = 30/59 (50%)
Query: 272 HEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
H + ++L + A D K YT L AAA+ +V LLD G D+N+ + G T L
Sbjct: 185 HIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Score = 35.0 bits (79), Expect = 0.33
Identities = 28/90 (31%), Positives = 39/90 (43%), Gaps = 14/90 (15%)
Query: 257 EQLSMEMILKAEEGN--HEWICRILKDNFASADV------------ADAKGYTVLAAAAT 302
E L + + + EGN C ++ DN +A++ D+KG T L AAA
Sbjct: 773 ELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAF 832
Query: 303 HCHNDIVNLLLDCGADVNKCSDEGLTALSM 332
H + + LLL A VN G T L M
Sbjct: 833 TDHVECLQLLLSHNAQVNSVDSTGKTPLMM 862
Score = 34.3 bits (77), Expect = 0.56
Identities = 25/65 (38%), Positives = 31/65 (47%), Gaps = 6/65 (9%)
Query: 276 CRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFL 335
CR L + D D G T L AAA + + +NLLL+ GAD NK G +
Sbjct: 388 CRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSP------ 441
Query: 336 LHYPA 340
LHY A
Sbjct: 442 LHYAA 446
Score = 33.9 bits (76), Expect = 0.73
Identities = 19/56 (33%), Positives = 31/56 (55%)
Query: 275 ICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 330
+ + L D + +A G T L A + + +VN L+DCGA VN+ +++G T L
Sbjct: 221 VVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPL 276
Score = 33.1 bits (74), Expect = 1.2
Identities = 55/198 (27%), Positives = 83/198 (41%), Gaps = 26/198 (13%)
Query: 530 IKLLLRRGADPNLCCVPMQV-LFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHI 588
++LL+ GAD N+ + L + G + +++ GA D + TPLHI
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDC---EDKNGNTPLHI 345
Query: 589 AAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLK-LSNEPGPPQAYY 647
AA E LL++ + A DT K G + P L LS +
Sbjct: 346 AARYGHE-------LLINTLITSGA------DTAKRGIHGMFPLHLAALSGFSDCCRKLL 392
Query: 648 ST--DTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWS-GHSPLSLSIA 704
S+ D P++ GRT LH A + + + LLL+ GA+ N G SPL + A
Sbjct: 393 SSGFDIDTPDDFGRTCLHAAAAGGN-----LECLNLLLNTGADFNKKDKFGRSPLHYAAA 447
Query: 705 SGNELVVKELLTQGADPN 722
+ N + L+ GA N
Sbjct: 448 NCNYQCLFALVGSGASVN 465
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 48.5 bits (114), Expect = 3e-05
Identities = 92/376 (24%), Positives = 143/376 (38%), Gaps = 82/376 (21%)
Query: 432 KGDSPLVKGSLGHVESGLEDVLGNTDRGSL----------CSAETKFESNVCVCDFSIEL 481
KGD+PL + + +E +L N + C+ +K S + S E
Sbjct: 564 KGDTPLHIAARWGYQGVIETLLQNGASTEIQNRLKETPLKCALNSKILSVMEAYHLSFER 623
Query: 482 SQAMLERSAQS-HSLLKMASPSPCTSSFDKGTMRRMALSMIERRKRWRTIKLLLRRGADP 540
Q E QS + S TSSF + + E +K +R ++ LLR AD
Sbjct: 624 RQKSSEAPVQSPQRSVDSISQESSTSSFSSMSA---SSRQEETKKDYREVEKLLRAVAD- 679
Query: 541 NLCCVPMQVLFLAVKAGDVDGVRLLLE-------------HGARTDICFPP-QLSTLTPL 586
GD++ VR LLE A + C P Q P
Sbjct: 680 ----------------GDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPA 723
Query: 587 HIAAALPGEEGVQIVELLLHAITDVDAKASDEDDTYKPGKLDLLPSSLKLSNEPGPPQAY 646
A G+ + +T D +S G+ DL+P LK G A
Sbjct: 724 QKRLAKVPASGLGV------NVTSQDG-SSPLHVAALHGRADLIPLLLKHGANAGARNA- 775
Query: 647 YSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLL-WSGHSPLSLSIAS 705
D A+P LH+AC++ +V+ LL A PN SG++PL + +
Sbjct: 776 ---DQAVP-------LHLACQQGHFQ-----VVKCLLDSNAKPNKKDLSGNTPLIYACSG 820
Query: 706 GNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLISHGADIL 765
G+ +V LL GA N KG +AL H+ ++ + +++ L+ HGA +
Sbjct: 821 GHHELVALLLQHGASINASNNKG-NTAL---------HEAVIEKHVFVVELLLLHGASV- 869
Query: 766 KPVMLRQGEKEAVGTA 781
+L + ++ AV A
Sbjct: 870 --QVLNKRQRTAVDCA 883
Score = 38.1 bits (87), Expect = 0.039
Identities = 23/66 (34%), Positives = 37/66 (56%), Gaps = 1/66 (1%)
Query: 265 LKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSD 324
L ++G H + + L D+ A + D G T L A + H+++V LLL GA +N ++
Sbjct: 783 LACQQG-HFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNN 841
Query: 325 EGLTAL 330
+G TAL
Sbjct: 842 KGNTAL 847
>gi|224282170 MORN repeat containing 2 [Homo sapiens]
Length = 79
Score = 47.4 bits (111), Expect = 6e-05
Identities = 21/49 (42%), Positives = 30/49 (61%)
Query: 13 GYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLSHREGYG 61
G+G+ +G Y GQF + HGLGTY +P+G+ +TG F + EG G
Sbjct: 3 GFGRLEHFSGAVYEGQFKDNMFHGLGTYTFPNGAKYTGNFNENRVEGEG 51
Score = 40.4 bits (93), Expect = 0.008
Identities = 18/55 (32%), Positives = 29/55 (52%)
Query: 1 MYQGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYMWPDGSSFTGTFYLS 55
+Y+G+F NM G G +++P G Y G F + G G Y G ++G F+ +
Sbjct: 14 VYEGQFKDNMFHGLGTYTFPNGAKYTGNFNENRVEGEGEYTDIQGLEWSGNFHFT 68
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 47.4 bits (111), Expect = 6e-05
Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 48/245 (19%)
Query: 533 LLRRGADPNLCCVPMQ---VLFLAVKAGDVDGVRLLLEHGARTDICFPPQLSTLTPLHIA 589
LL PN+ CV L A G D V +LL + A T++ PLH+A
Sbjct: 64 LLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVA---DSKGCYPLHLA 120
Query: 590 AALPGEEGVQIVELLLH---AITDVDAKASDEDDTY----KPGKLDLLPSSLKLSNEPGP 642
A + QIV LL+H + T V+ + +D + + G +++ L+ +P
Sbjct: 121 A---WKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTM 177
Query: 643 PQAYYSTDTALPEEGGRTALHMACEREDDNKCARDIVRLLLSHGANPNLLWSG---HSPL 699
+ T L GR ++V++LL+ A+PNLL H+PL
Sbjct: 178 RNNKFETPLDLAALYGRL----------------EVVKMLLN--AHPNLLSCNTKKHTPL 219
Query: 700 SLSIASGNELVVKELLTQGADPNLPLTKGLGSALCVACDLTYEHQRNMDSKLALIDRLIS 759
L+ +G++ VV+ LL G D N +GSAL H+ + K ++ L++
Sbjct: 220 HLAARNGHKAVVQVLLDAGMDSNYQTE--MGSAL---------HEAALFGKTDVVQILLA 268
Query: 760 HGADI 764
G D+
Sbjct: 269 AGTDV 273
Score = 33.9 bits (76), Expect = 0.73
Identities = 33/125 (26%), Positives = 54/125 (43%), Gaps = 15/125 (12%)
Query: 253 CGPKEQLSMEMILKAEEGNHEWICRILKDNFASADVADAKGYTVLAAAATHCHNDIVNLL 312
C K+ + + A H+ + ++L D ++ G + L AA D+V +L
Sbjct: 211 CNTKKHTPLHL---AARNGHKAVVQVLLDAGMDSNYQTEMG-SALHEAALFGKTDVVQIL 266
Query: 313 LDCGADVNKCSDEGLTALSMCFLLHYPAQSFKPNVA--------ERTIPEPQEPPKFPVV 364
L G DVN + GLTAL + P+Q + A +R+ E + P P
Sbjct: 267 LAAGTDVNIKDNHGLTALDT--VRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPP-PQP 323
Query: 365 PILSS 369
P++SS
Sbjct: 324 PLISS 328
Score = 31.2 bits (69), Expect = 4.7
Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 6/56 (10%)
Query: 285 SADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLLHYPA 340
+ + D+ GYT L AA + H D+V +LL A N +G C+ LH A
Sbjct: 72 NVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKG------CYPLHLAA 121
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.425
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,277,444
Number of Sequences: 37866
Number of extensions: 2021523
Number of successful extensions: 7107
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 162
Number of HSP's successfully gapped in prelim test: 116
Number of HSP's that attempted gapping in prelim test: 5228
Number of HSP's gapped (non-prelim): 1649
length of query: 941
length of database: 18,247,518
effective HSP length: 112
effective length of query: 829
effective length of database: 14,006,526
effective search space: 11611410054
effective search space used: 11611410054
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.