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Search of human proteins with 75709196
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75709196 NACHT, leucine rich repeat and PYD containing 7
isoform 2 [Homo sapiens]
(980 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 1994 0.0
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 1933 0.0
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 1857 0.0
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 1134 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 547 e-155
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 461 e-129
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 443 e-124
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 438 e-122
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 438 e-122
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 436 e-122
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 433 e-121
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 420 e-117
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 410 e-114
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 409 e-114
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 396 e-110
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 359 6e-99
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 316 8e-86
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 316 8e-86
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 316 8e-86
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 315 1e-85
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 312 9e-85
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 312 9e-85
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 244 3e-64
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 219 1e-56
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 135 2e-31
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 127 5e-29
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 127 5e-29
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 127 5e-29
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 127 5e-29
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 127 5e-29
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 1994 bits (5165), Expect = 0.0
Identities = 980/980 (100%), Positives = 980/980 (100%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPK 960
EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPK
Sbjct: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPK 960
Query: 961 LTIDCNASGATAPPCCDFFC 980
LTIDCNASGATAPPCCDFFC
Sbjct: 961 LTIDCNASGATAPPCCDFFC 980
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 1933 bits (5008), Expect = 0.0
Identities = 970/1037 (93%), Positives = 971/1037 (93%), Gaps = 57/1037 (5%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
Query: 901 EACSLTNLDLSINQIARG-------------------LW------ILCQ----------- 924
EACSLTNLDLSINQIARG LW CQ
Sbjct: 901 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 960
Query: 925 ---------------------ALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
L +LK LRLKTYETNLEIKKLLEEVKEKNPKLTI
Sbjct: 961 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
Query: 964 DCNASGATAPPCCDFFC 980
DCNASGATAPPCCDFFC
Sbjct: 1021 DCNASGATAPPCCDFFC 1037
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform 1
[Homo sapiens]
Length = 1009
Score = 1857 bits (4809), Expect = 0.0
Identities = 942/1037 (90%), Positives = 943/1037 (90%), Gaps = 85/1037 (8%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN
Sbjct: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK
Sbjct: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEK 120
Query: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA
Sbjct: 121 EGWRNSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPA 180
Query: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS
Sbjct: 181 GVGKTTLAKKCMLDWTDCNLSPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPS 240
Query: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT
Sbjct: 241 ILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVT 300
Query: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG
Sbjct: 301 TRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLG 360
Query: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA
Sbjct: 361 SAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAA 420
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY
Sbjct: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC
Sbjct: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN
Sbjct: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
Query: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRS 660
TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE
Sbjct: 601 TSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE----------------- 643
Query: 661 LRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 720
SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY
Sbjct: 644 -----------SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAY 692
Query: 721 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 780
RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE
Sbjct: 693 RDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAE 752
Query: 781 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 840
FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA
Sbjct: 753 FFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAA 812
Query: 841 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 900
VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ
Sbjct: 813 VLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQ 872
Query: 901 EACSLTNLDLSINQIARG-------------------LW------ILCQ----------- 924
EACSLTNLDLSINQIARG LW CQ
Sbjct: 873 EACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQK 932
Query: 925 ---------------------ALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
L +LK LRLKTYETNLEIKKLLEEVKEKNPKLTI
Sbjct: 933 LETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
Query: 964 DCNASGATAPPCCDFFC 980
DCNASGATAPPCCDFFC
Sbjct: 993 DCNASGATAPPCCDFFC 1009
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 1134 bits (2933), Expect = 0.0
Identities = 610/977 (62%), Positives = 710/977 (72%), Gaps = 56/977 (5%)
Query: 1 MTSPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVN 60
++S Q+ + LQ LLEQL++DEL FK L+ F L LQK P EV++ADGK+L EIL
Sbjct: 2 VSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTT 61
Query: 61 TSSENWIRNATVNILEEMNLTELCKMAKAEMMEDGQ------------VQEIDNPELGDA 108
W+ A++ + E+M+ +L + AK E+ E + + P L D
Sbjct: 62 HCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPL-DV 120
Query: 109 EEDSELAKP---------------------GEKEGWRNSME-----KQSLVWKNTFWQGD 142
+E E K G+K N K +WK+ W GD
Sbjct: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKS--WPGD 178
Query: 143 IDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNLSP 202
+ R + IPF NPR YTVVL+GPAG+GKTTLA+K MLDW + NL
Sbjct: 179 SKEVQV-MAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIH 237
Query: 203 TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPP 262
+YAFYLSC+ELSR+GPCSFAEL+ +DWPELQDDIP ILAQA++ILFV+DG DEL P
Sbjct: 238 KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAP 297
Query: 263 GALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVE 322
GALI+DICGDWEKKKPVPVLLGSLL R MLP+AALLVTTRPRALRDL++LA++PIY+RVE
Sbjct: 298 GALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVE 357
Query: 323 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 382
GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED
Sbjct: 358 GFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGED 417
Query: 383 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQE 442
PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQ SV HREDLERLGVQE
Sbjct: 418 PVPTCLTRTGLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQTSVLHREDLERLGVQE 477
Query: 443 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQK 502
SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY LEKEE EDRDGH WDIGDVQK
Sbjct: 478 SDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHTWDIGDVQK 537
Query: 503 LLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHANKP 562
LLSG ERL+NPDLIQ G++ FGLANEKRAKELEATFGCRMSPDIKQELL+C
Sbjct: 538 LLSGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRCDISCKGGHS 597
Query: 563 LSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSL 622
+VTDL+E+LGCLYESQEEEL K V+A FKEIS+HL N +V+ SF +KHC++LQK+SL
Sbjct: 598 -TVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVKHCRNLQKMSL 655
Query: 623 QVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682
QV K EN E D E ER ++ D L WTD CS+F SN +L L +
Sbjct: 656 QVIKENLPENVTASESDAEVER---------SQDDQHMLPFWTDLCSIFGSNKDLMGLAI 706
Query: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHI 742
SFLS S VRILC+ + TCHLQ+V KN++P A+R+ CLA G KT+T+LTL G+
Sbjct: 707 NDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGND 766
Query: 743 EWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLL 802
+ + M LC++LR+ +CNL+YL L AT +QWA+ L+ NQSL + LS N LL
Sbjct: 767 QDD--MFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELL 824
Query: 803 DEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTG 862
DEGA LLY T+ PK FLQ LSLENC LTEA+CKDLAAVLVVS++LTHLCLAKNPIG+TG
Sbjct: 825 DEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTG 884
Query: 863 VKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWI 921
VKFLCEGL YP+CKLQTLVL C IT GC L++ LQE SL LDL +N I +G+
Sbjct: 885 VKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKF 944
Query: 922 LCQALENPNCNLKHLRL 938
LC+AL P CNL+ L L
Sbjct: 945 LCEALRKPLCNLRCLWL 961
Score = 43.9 bits (102), Expect = 7e-04
Identities = 36/126 (28%), Positives = 57/126 (45%), Gaps = 1/126 (0%)
Query: 837 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896
DL ++ +K L L + + + + V+ LCE ++ C LQ +V + S R L
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLC 748
Query: 897 EALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
AL+ ++T L L N LC+ L +P CNL++L L + + L E
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALE 808
Query: 957 KNPKLT 962
N LT
Sbjct: 809 VNQSLT 814
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 547 bits (1409), Expect = e-155
Identities = 346/949 (36%), Positives = 510/949 (53%), Gaps = 41/949 (4%)
Query: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
++ L LE+LN++EL +FK L +E TPW+EV++A + LA ++
Sbjct: 12 DFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKKYYPGEK 70
Query: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNS 126
+ ++ I +MNL +LC+ AK E+ Q D+ + G+ +ED E A G+ +RN
Sbjct: 71 AWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQE-AVLGDGTEYRNR 129
Query: 127 M-EKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFL-NPRTPRKLTPYTVVLHGPAGVGK 184
+ EK + W G ++FH + ++++ + L + P VVL G AGVGK
Sbjct: 130 IKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGAAGVGK 189
Query: 185 TTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILA 243
TTL +K MLDW + +L +Y FYL+ +E++++ SFA+LISKDWP + I I+
Sbjct: 190 TTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPIEEIMY 249
Query: 244 QAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP 303
Q +LF++D DEL +C DW ++ PV L+ SLL++ MLP A+LLVTTR
Sbjct: 250 QPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLLVTTRL 309
Query: 304 RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAP 363
+ L+ L + YV + G E+ R Y + F D+ AM+ F ++SN LF + P
Sbjct: 310 TTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFSMCQVP 369
Query: 364 AVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF----------PQGAQLRGALR 413
VCW CT LK QMEKG D TC T T LF ++ S F P AQLR
Sbjct: 370 LVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQLR---- 425
Query: 414 TLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQ 473
L +AA+G+W VF+RE+L RLG+ +SD+ F+D +I+++D + CY F HL Q+
Sbjct: 426 RLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQE 485
Query: 474 FLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKE 533
F A+FY L K E + D++ LL K+P L Q+ FLFGL NE R K+
Sbjct: 486 FFAAMFYML-KGSWEAGNPSCQPFEDLKSLLQSTS-YKDPHLTQMKCFLFGLLNEDRVKQ 543
Query: 534 LEATFGCRMSPDIKQELLQCKAHLHANKPLSVTDLK--EVLGCLYESQEEELAKVVVAPF 591
LE TF C+MS IK +LLQC L N S + L E+ CLYE+Q++ + F
Sbjct: 544 LERTFNCKMSLKIKSKLLQCMEVL-GNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCF 602
Query: 592 KEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT-I 650
+++I++ ++ SF LKHC+ L+ + L V + FE+ T +
Sbjct: 603 PKVAINICEKIHLLVSSFCLKHCRCLRTIRLSVT--------------VVFEKKILKTSL 648
Query: 651 PNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVE 710
P R W D CS+ +N +L+ L++ S L S++ IL + C LQK+
Sbjct: 649 PTNTWDGDRITHCWQDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLL 708
Query: 711 IKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGG 770
+K +T +D + I K L HL L G + + LC+ L++ +C LQ LRL
Sbjct: 709 LKFITFPDGCQDISTSLIHNKNLMHLDLKGSDIGDNGVK-SLCEALKHPECKLQTLRLES 767
Query: 771 HCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRL 830
T L +QSL L LS N LLD+G LL + + PK +L+ LSLE+C L
Sbjct: 768 CNLTVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGL 827
Query: 831 TEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKL 890
TEA C+ L+ L+ +K+LTHLCLA N +GD GVK + + L + C L++LVL++C T L
Sbjct: 828 TEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSL 887
Query: 891 GCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
YLS +L SLT+LDL N + G+ +LC +P+CNL+ L L
Sbjct: 888 SSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLEL 936
Score = 155 bits (393), Expect = 1e-37
Identities = 121/334 (36%), Positives = 172/334 (51%), Gaps = 15/334 (4%)
Query: 645 CTYLTIPNWARQDLR--SLRLWTDFCSLFSSNS-----NLKFLEVKQSFLSDSSVRILCD 697
C L P Q LR S L T FC L SN+ +L FL + + L D V++LC+
Sbjct: 750 CEALKHPECKLQTLRLESCNL-TVFCCLNISNALIRSQSLIFLNLSTNNLLDDGVQLLCE 808
Query: 698 HVTRSTCHLQKVEIKNVTPDTAYRDFC-LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLL 756
+ C+L+++ +++ A ++ LA I K LTHL LA ++ + + LM D L
Sbjct: 809 ALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLM-SDAL 867
Query: 757 RNHKCNLQYLRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
++ +C L+ L L C +E+ L N+SL HL L +N L D G LL
Sbjct: 868 QHAQCTLKSLVLR-RCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRH 926
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P LQ L L C LT A C DLA+V++ + L L L N + D GVK LC+ L YP+C
Sbjct: 927 PSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNC 986
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLK 934
+Q L L+ C +T L C+ LS AL L ++L+ N + G+ L + L++P C L+
Sbjct: 987 NIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQ 1046
Query: 935 HLRLKTYETNLEIKKLLEEVKEKNPKLTI--DCN 966
L L + E +KLLE V NP L I DCN
Sbjct: 1047 VLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/159 (29%), Positives = 84/159 (52%), Gaps = 12/159 (7%)
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
+ LK + L+ +RLS V+ ++ + K L + + R+T +DL +VL
Sbjct: 620 FCLKHCRCLRTIRLSVTVVFEKKIL---------KTSLPTNTWDGDRITHC-WQDLCSVL 669
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
++ L L L + + + + L L +P+CKLQ L+L+ + GC+ +S +L
Sbjct: 670 HTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDISTSLIHN 728
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKT 940
+L +LDL + I G+ LC+AL++P C L+ LRL++
Sbjct: 729 KNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLES 767
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 461 bits (1185), Expect = e-129
Identities = 325/1032 (31%), Positives = 517/1032 (50%), Gaps = 124/1032 (12%)
Query: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
++ L LE+L ++E + FK L L+ L++ PW+EV++A ++LA +L+ E
Sbjct: 8 DFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQ 67
Query: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRN- 125
N T+ I ++M+ +LC E G + AK W +
Sbjct: 68 AWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKTYQAHAKQKFSRLWSSK 114
Query: 126 SMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKT 185
S+ + L ++ Q + D+ ++ F P + PR TV++ GP G+GKT
Sbjct: 115 SVTEIHLYFEEEVKQEECDHL-------DRLFAPKEAGKQPR-----TVIIQGPQGIGKT 162
Query: 186 TLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQ 244
TL K M+ W+D + Y FY C+EL + P S A+LIS++WP+ I I++Q
Sbjct: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
Query: 245 AQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTR-- 302
+R+LFV+D +EL+ D+CGD +K+PV VLL SLL++KMLP A+LL+ +
Sbjct: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
Query: 303 -PRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGS 361
P+ LRD +++ IY + GF E DR YF F D +AM AF L+R + LF +
Sbjct: 283 CPKELRDQVTISE--IY-QPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQ 339
Query: 362 APAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTL 415
P +CWI+CT+LK +M+KG+D TC + T ++ F+ + F P+GA Q + L+ L
Sbjct: 340 IPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKAL 399
Query: 416 SLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFL 475
LAA+G+W F +DL R GV ++D+ L IL + + Y F+H+ Q+F
Sbjct: 400 CSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFC 459
Query: 476 TALFYALEKEEGEDRDGHAWDIGDVQKLL-SGEERLKNPDLIQVGHFLFGLANEKRAKEL 534
ALFY L+ + VQ+LL + E+ + I +G FL GL N+K ++L
Sbjct: 460 AALFYLLKSHLDHPHPA----VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
Query: 535 EATFGCRMSPDIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKE 593
+A FG ++S +IKQ++ QC L P D + CL+E Q+ K V +E
Sbjct: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
Query: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
+ H+ + +++ ++ LK+C L+KL V + VF + D Y
Sbjct: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKE------DEHSSTSDY------ 622
Query: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
SL W CS+ +++ +L+ L+V+ S LS+S+ C+ + +C LQK+ I N
Sbjct: 623 ------SLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINN 676
Query: 714 VT---------------PDTAYRDFCLAFIGKKTLTHL---------------------- 736
V+ PD Y F L + + + L
Sbjct: 677 VSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
Query: 737 -----TLAGHIEWER-------------TMMLMLCDLLRNHKCNLQYLRLGGHCATPEQW 778
LAG + + T + +LC+ L + L YL L C EQ
Sbjct: 737 PIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLML-AFCHLSEQC 795
Query: 779 AEFF-YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
E+ +L N+S+++L LSANVL DEG L + + P L L L C +T A C+D
Sbjct: 796 CEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCED 855
Query: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
LA+ L+ ++ L L + N IGD GV+ LC L++ DC+L+ L L++C +T C+ L+
Sbjct: 856 LASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLAS 915
Query: 898 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
L + +L L+L++N + G+ +LC+AL +P C L+ L L+ + + E + LL +E
Sbjct: 916 VLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEE 975
Query: 957 KNPKLTI--DCN 966
+NP LTI DC+
Sbjct: 976 RNPNLTITDDCD 987
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 443 bits (1139), Expect = e-124
Identities = 312/979 (31%), Positives = 475/979 (48%), Gaps = 87/979 (8%)
Query: 14 LEQLNEDELKSFKSLL--------WAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSEN 65
L L++ +L+ FK L W+ P + + PW+ + AD L+ +L +
Sbjct: 21 LMALDQYQLEEFKLCLEPQQLMDFWSAP-QGHFPRIPWANLRAADPLNLSFLLDEHFPKG 79
Query: 66 WIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNP---------------------- 103
+ I + MNLT LC+ +AEM E+ Q QE+ +P
Sbjct: 80 QAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQGCQD 139
Query: 104 ----ELGDAEEDSE-----------------LAKPGEKEGWRNSMEKQSL-VWKNTFWQG 141
EL + EE++ L + + +R +M+ + L W N W
Sbjct: 140 PNQEELDELEEETGNVQAQGCQDPNQEEPEMLEEADHRRKYRENMKAELLETWDNISWPK 199
Query: 142 DIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
D + ++ L+P R T+VL G AGVGKTTLA + ML W + L
Sbjct: 200 DHVYIRNTSKDEHEELQRLLDPNRTRAQAQ-TIVLVGRAGVGKTTLAMQAMLHWANGVLF 258
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FYLSC ++ M +FAELIS DWP+ I ++Q +++LF++DG +E+ +
Sbjct: 259 QQRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMSQPEKLLFIIDGFEEIII 318
Query: 261 PPGALIQ----DICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQP 316
C DW ++ PV +L SLLK++++P A LL+T + +RDL+ P
Sbjct: 319 SESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLATLLITIKTWFVRDLKASLVNP 378
Query: 317 IYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQ 376
+V++ GF +D R YF+RHF D + + + +R N LF SAP VCW VC+ LK
Sbjct: 379 CFVQITGFTGDDLRVYFMRHFDDSSEVEKILQQLRKNETLFHSCSAPMVCWTVCSCLKQP 438
Query: 377 MEKGEDPVPTCLTRTGLFLRFLCSRFPQGA------QLRGALRTLSLLAAQGLWAQMSVF 430
+ D T T L+ F + F G R L LA +GLW+ F
Sbjct: 439 KVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADDSWPGQWRALCSLAIEGLWSMNFTF 498
Query: 431 HREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDR 490
++ED E G++ + + +IL++ GC +F HLSFQ+F A+ + L EE +
Sbjct: 499 NKEDTEIEGLEVPFIDSLYEFNILQKINDCGGCTTFTHLSFQEFFAAMSFVL--EEPREF 556
Query: 491 DGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQEL 550
H+ +++ LL K V F FGL N+ A+ELE T C++SP + +EL
Sbjct: 557 PPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFFFGLLNKNIARELEDTLHCKISPRVMEEL 616
Query: 551 LQCKAHLHANKPLSVT-DLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSF 609
L+ L + S+ + + CL+ESQEE+ K ++ E+ +++ E+ SF
Sbjct: 617 LKWGEELGKAESASLQFHILRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQASSF 676
Query: 610 SLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCS 669
LKHC+ L KL L V+ + E D+E I ++ D R + W CS
Sbjct: 677 CLKHCKRLNKLRLSVSSHI-------LERDLE--------ILETSKFDSR-MHAWNSICS 720
Query: 670 LFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIG 729
+N NL L++ S L SSV+ LC + C +QK+ K+VTP+ +D +A G
Sbjct: 721 TLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQDLIIALQG 780
Query: 730 KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQ 789
LTHL + + + T+ L+L LR+ CNL+YL L + + L + Q
Sbjct: 781 NSKLTHLNFSSN-KLGMTVPLIL-KALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQ 838
Query: 790 SLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLT 849
+ L L N L D+G LL +T PK L+ L L C+L +CK L+ L+ ++ LT
Sbjct: 839 HVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLT 898
Query: 850 HLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLD 909
HL L+KN + D GVKFLCE L PD LQ+L L CS T+ GC L+ AL ++ LD
Sbjct: 899 HLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILD 958
Query: 910 LSINQIA-RGLWILCQALE 927
L N + G+ +LC+AL+
Sbjct: 959 LGENDLQDDGVKLLCEALK 977
Score = 94.4 bits (233), Expect = 5e-19
Identities = 67/197 (34%), Positives = 97/197 (49%), Gaps = 7/197 (3%)
Query: 687 LSDSSVRILCDHVTRSTCHLQKVEI---KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIE 743
L D +++LC +T C L+++E+ + P A + A + ++LTHL L+ +
Sbjct: 850 LQDDGIKLLCAALTHPKCALERLELWFCQLAAP--ACKHLSDALLQNRSLTHLNLSKNSL 907
Query: 744 WERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLD 803
+ + LC+ L NLQ L L G T E E L N ++K L L N L D
Sbjct: 908 RDEGVKF-LCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQD 966
Query: 804 EGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGV 863
+G LL + + +P L L L C LT A C+ L +VL SK L +L L N + GV
Sbjct: 967 DGVKLLCEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGV 1025
Query: 864 KFLCEGLSYPDCKLQTL 880
K LC+ L C+LQ L
Sbjct: 1026 KMLCKALKKSTCRLQKL 1042
Score = 67.0 bits (162), Expect = 8e-11
Identities = 53/186 (28%), Positives = 87/186 (46%), Gaps = 3/186 (1%)
Query: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
W L N++L L LS + L L + P+ +Q L+ ++ E +D
Sbjct: 715 WNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVT-PEWVLQD 773
Query: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
L L + KLTHL + N +G T V + + L + C L+ L L++C+++ C+ L+
Sbjct: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
Query: 898 ALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
L +T L L N++ G+ +LC AL +P C L+ L L + K L +
Sbjct: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
Query: 957 KNPKLT 962
+N LT
Sbjct: 893 QNRSLT 898
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 438 bits (1126), Expect = e-122
Identities = 328/1028 (31%), Positives = 501/1028 (48%), Gaps = 81/1028 (7%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE-------RCTYLTIPNWA-RQDLRSLR 662
+++C ++ LSL FL N E + E E +C + + A L +
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
Query: 663 LWTDFC----SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIK--NVTP 716
L + FC S+ S++ +L L++ + L D +R+LC+ + C+++++ + ++
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 717 DTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPE 776
+ + D L + L L L+ + + + L LC L++ CNL+ L L C T
Sbjct: 785 ECCF-DISLVLSSNQKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSA 842
Query: 777 QWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCK 836
+ VL + SL L + N L D G +L + P+ LQ L L N LT C
Sbjct: 843 CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCS 902
Query: 837 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896
L++VL ++ LTHL L N +GD G+K LCEGL +PDCKLQ L L C++T C LS
Sbjct: 903 ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 962
Query: 897 EALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVK 955
L + SL L L N + G+ + C+ L+ +C L++L L N E K LE ++
Sbjct: 963 TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQ 1022
Query: 956 EKNPKLTI 963
E+ P+LT+
Sbjct: 1023 EEKPELTV 1030
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 438 bits (1126), Expect = e-122
Identities = 328/1028 (31%), Positives = 501/1028 (48%), Gaps = 81/1028 (7%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDI--GDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 Q-CKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ + A K E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFE-------RCTYLTIPNWA-RQDLRSLR 662
+++C ++ LSL FL N E + E E +C + + A L +
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSH 724
Query: 663 LWTDFC----SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIK--NVTP 716
L + FC S+ S++ +L L++ + L D +R+LC+ + C+++++ + ++
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 717 DTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPE 776
+ + D L + L L L+ + + + L LC L++ CNL+ L L C T
Sbjct: 785 ECCF-DISLVLSSNQKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSA 842
Query: 777 QWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCK 836
+ VL + SL L + N L D G +L + P+ LQ L L N LT C
Sbjct: 843 CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCS 902
Query: 837 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 896
L++VL ++ LTHL L N +GD G+K LCEGL +PDCKLQ L L C++T C LS
Sbjct: 903 ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS 962
Query: 897 EALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVK 955
L + SL L L N + G+ + C+ L+ +C L++L L N E K LE ++
Sbjct: 963 TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQ 1022
Query: 956 EKNPKLTI 963
E+ P+LT+
Sbjct: 1023 EEKPELTV 1030
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 436 bits (1122), Expect = e-122
Identities = 293/938 (31%), Positives = 477/938 (50%), Gaps = 33/938 (3%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
+ ++ +EL+ FK LL L W +VE A ++ +L+ + T N
Sbjct: 45 MRNVSHEELQRFKQLLLT-ELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAWDVTSN 103
Query: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWR-NSMEKQSL 132
I MN ++C + + E+ E ++ +G+ + + E + G+ ++ N MEK
Sbjct: 104 IFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVMEKFFP 163
Query: 133 VWKNTFWQGDIDNFHDDVTLRNQRFIP-FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
+W T W G+ +F R++ ++P L P+ P+ P TV + G G+GKT LAKK
Sbjct: 164 IWDITTWPGNQRDFFYQGVHRHEEYLPCLLLPKRPQGRQPKTVAIQGAPGIGKTILAKKV 223
Query: 192 MLDWTDCNLSPTLRY-AFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
M +W R+ AFY C+E+++ SF+ELI + WP QD + I+++ ++L
Sbjct: 224 MFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSKPDQLLL 283
Query: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
++DG +EL ++D+ DW +K P VLL SLL + MLP A LL+ R + + +
Sbjct: 284 LLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFTSWQTCK 343
Query: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
L + P V + GF ++ YF +FG ++ + N LF + P VCW+VC
Sbjct: 344 PLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPVVCWMVC 403
Query: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQ------LRGALRTLSLLAAQGLW 424
+ LK QME+G + +C T +F+R++ S FP A+ + L L LAA +W
Sbjct: 404 SGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHLAADSMW 463
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
+ V +EDLE + ++ + FL ILR+ + Y F ++FQ+F ALFY L
Sbjct: 464 HRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAALFYVLCF 523
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
+ ++ H ++Q+L++ K+ L +G FLFG NE A +E +F C++S
Sbjct: 524 PQ-RLKNFHVLSHVNIQRLIASPRGSKS-YLSHMGLFLFGFLNEACASAVEQSFQCKVSF 581
Query: 545 DIKQELLQCKAHLH-ANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
K++LL+ LH + P + + ++ CL+E +EE + + ++ + + N E
Sbjct: 582 GNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRIGNNKE 641
Query: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSL-R 662
V +F LK CQ L ++ L V N+M+ + + + P + L R
Sbjct: 642 VQVSAFCLKRCQYLHEVELTVTL-----NFMN------VWKLSSSSHPGSEAPESNGLHR 690
Query: 663 LWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRD 722
W D CS+F++N L+ L + S L ++ L + C LQK+ ++ V +D
Sbjct: 691 WWQDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQD 750
Query: 723 FCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
G + L +L + H+E E + +LC +LR+ +C LQ LRL ATP W +
Sbjct: 751 LIGVLTGNQHLRYLEIQ-HVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLG 809
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
L+ N LK L L N L + GA L L+ LS+ENC LT+ +C+ LA+ L
Sbjct: 810 NNLQGNGHLKTLILRKNSLENCGAYYLSVAQ------LERLSIENCNLTQLTCESLASCL 863
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
SK LTHL LA+N + D G K + L + C LQ LVL++C +T C+ + AL +
Sbjct: 864 RQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKN 923
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
+L +LDLS N + G+ +LC+AL+NP+C L+ L L+
Sbjct: 924 KTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELE 961
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 433 bits (1113), Expect = e-121
Identities = 313/999 (31%), Positives = 505/999 (50%), Gaps = 88/999 (8%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDV-LQKTPWSEVEEADGKKLAEILVNTSSENWIRNATV 72
L++L ++E FK LL PLE L+ PW+E+++A + +A++L T+
Sbjct: 15 LKELRKEEFWKFKELLKQ-PLEKFELKPIPWAELKKASKEDVAKLLDKHYPGKQAWEVTL 73
Query: 73 NILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRNSMEKQ-S 131
N+ ++N +L A+ EM NP +R M++
Sbjct: 74 NLFLQINRKDLWTKAQEEMRNKL------NP-------------------YRKHMKETFQ 108
Query: 132 LVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKC 191
L+W+ ++F+ + T++N+ LN +TVVL GP G+GKTTL +K
Sbjct: 109 LIWEKETCLHVPEHFYKE-TMKNE--YKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKV 165
Query: 192 MLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILF 250
MLDW + NL + F+L+ E++ + S EL+S+DWPE + I I +Q +RILF
Sbjct: 166 MLDWAEGNLWKDRFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILF 225
Query: 251 VVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQ 310
++DG ++LK L D+ DW +++P+P++L SLL++KMLP ++LL+ A++
Sbjct: 226 IMDGFEQLKFNL-QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHY 284
Query: 311 LLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVC 370
+ + P +++ GF E ++++YF FG++ +A++ F +R N LF L P CW+VC
Sbjct: 285 FMLRHPKLIKLLGFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVC 344
Query: 371 TTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQL------RGALRTLSLLAAQGLW 424
T +K ++E+GED T L+ FL + F G+Q R L++L LAA+G+W
Sbjct: 345 TCVKQRLERGEDLEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIW 404
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
VF DL R G+ ES+ +++ +L++ C++F+HL Q+F A+FY L++
Sbjct: 405 TYTFVFSHGDLRRNGLSESEGVMWVGMRLLQR---RGDCFAFMHLCIQEFCAAMFYLLKR 461
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSP 544
+ + IG + +L+ L QVG F+FG++ E+ LE +FG +S
Sbjct: 462 PKDDPNPA----IGSITQLVRASVVQPQTLLTQVGIFMFGISTEEIVSMLETSFGFPLSK 517
Query: 545 DIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSE 603
D+KQE+ QC L +E+ L+E+QE+E V+ F+E+ I++ N
Sbjct: 518 DLKQEITQCLESLSQCEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEH 577
Query: 604 VMHCSFSLKHCQDLQKLSLQVAKGVFLEN---YMDFELDIEF--ERCT-YLTIPNWARQD 657
++ SF LKHCQ L L + V + +F ++ D+ + + E C+ ++T N+ D
Sbjct: 578 LVIASFCLKHCQHLTTLRMCV-ENIFPDDSGCISDYNEKLVYWRELCSMFITNKNFQILD 636
Query: 658 LRSLRL------------WTDFCSL----FSS---------------NSNLKFLEVKQSF 686
+ + L C L F+S N +LK L + +
Sbjct: 637 MENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLLSLYGTS 696
Query: 687 LSDSSVRILCDHVTRSTCHLQKVEI-KNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWE 745
LS S +R LC+ + C ++++ + K D L HL+L + +
Sbjct: 697 LSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRD 756
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
M L LC+ L++ C L+ L L C T VL ++SL L L +N L D G
Sbjct: 757 EGMTL-LCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNG 815
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
L + P ++ L L C LT SCKD+AAVL+ + KL L L N IGDTGV+
Sbjct: 816 VASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQ 875
Query: 866 LCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS-INQIARGLWILCQ 924
LC L +P CKL+ L LQ C IT+ C ++ AL +L +L+L I A + +LC+
Sbjct: 876 LCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCE 935
Query: 925 ALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
AL +P+C L+ L L + E +K+L V+EK P LTI
Sbjct: 936 ALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 420 bits (1080), Expect = e-117
Identities = 318/978 (32%), Positives = 472/978 (48%), Gaps = 62/978 (6%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L T LE+L ELK FK L E K PW +E+A ++A++L+
Sbjct: 13 LSTYLEELEAVELKKFKLYLGT-ATELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
Query: 70 ATVNILEEMNLTELCKMAKAE-MMED---GQVQEIDNPELGDAEEDSELAKPGEKEGWRN 125
++ E +N +L + + E ++ D G + N E + +E +R+
Sbjct: 72 LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
Query: 126 SMEKQ-SLVWKNTFWQGDIDNF------------HDDVTLRNQRFIP------------- 159
+ ++ L+ G+ N H + Q+ +
Sbjct: 132 YVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQA 191
Query: 160 -------FLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLS 211
P R P TVV+ G AG+GK+ LA K MLDW D L Y FY++
Sbjct: 192 SPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYIN 251
Query: 212 CKELSRMGP-CSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDIC 270
C+E+++ CS +LI WPE + ++ +R+LF++DG DELK C
Sbjct: 252 CREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWC 311
Query: 271 GDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRR 330
WE+K+P +LL SL+++K+LP +LL+TTRP AL L L + P +V + GF E +R+
Sbjct: 312 LCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERK 371
Query: 331 AYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTR 390
YF ++F + +QA + F +R N LF + P VCW+VCT L+ Q+E G T T
Sbjct: 372 EYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTT 431
Query: 391 TGLFLRFLCSRF---PQGAQLRGA--LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDL 445
T +++ +L S P +L+ R L LAA GLW Q +F +DL + G+ D+
Sbjct: 432 TAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDV 491
Query: 446 RLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS 505
FL+ +I ++D + YSFIHLSFQ+F A++Y L +EGE G A DV +LL+
Sbjct: 492 SAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYIL--DEGE---GGAGPDQDVTRLLT 546
Query: 506 GEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQ-CKAHLHANKPLS 564
+ L FLFGL NE+ LE + ++SP IK +LLQ ++ ++
Sbjct: 547 EYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTL 606
Query: 565 VTDLKEVLGCLYESQEEELAKVVVAPFKEISI-HLTNTSEVMHCSFSLKHCQDLQKLSLQ 623
E CLYE QEEE + ++ F+ I + ++ + E M SF LK C+ Q L L
Sbjct: 607 QQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLY 666
Query: 624 VAKGVFLENYMDFELDIEFERCTYLTIP-NWARQDLRSLRLWTDFCSLFSSNSNLKFLEV 682
A + + D + +P D S L C +N NL L +
Sbjct: 667 GA--TYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALC----TNPNLIELSL 720
Query: 683 KQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGH 741
++ L V++LC + C LQ + +K +A D A I K LT + L+G+
Sbjct: 721 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780
Query: 742 IEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVL 801
MML LC+ LR+ +C LQ ++L E VL N L L L+ N L
Sbjct: 781 GVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNAL 839
Query: 802 LDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDT 861
D G LL + + P L+ L L+ CRLT A+C +LA+ L V++ L L L+ N +GD
Sbjct: 840 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL 899
Query: 862 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLW 920
GV LCEGL +P CKLQTL L C + C LS LQ +L LDLS N + GLW
Sbjct: 900 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLW 959
Query: 921 ILCQALENPNCNLKHLRL 938
+L + L++P C L+ L L
Sbjct: 960 LLAEGLQHPACRLQKLWL 977
Score = 107 bits (267), Expect = 5e-23
Identities = 59/156 (37%), Positives = 89/156 (57%), Gaps = 1/156 (0%)
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N +L L L N L G LL + + P LQ L L+ CR++ ++C+DL+A L+
Sbjct: 709 LCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIA 768
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACS 904
+K LT + L+ N +G G+ LCEGL +P C+LQ + L++C + C+ ++ L
Sbjct: 769 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 828
Query: 905 LTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
L LDL+ N + GL +LCQ L +P C L+ L LK
Sbjct: 829 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
Score = 90.9 bits (224), Expect = 5e-18
Identities = 53/145 (36%), Positives = 79/145 (54%), Gaps = 1/145 (0%)
Query: 818 HFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKL 877
H L + E L +A + LAA L + L L L +N +G GVK LC+GL +P+CKL
Sbjct: 685 HTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKL 744
Query: 878 QTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHL 936
Q L L++C I+ C LS AL +LT +DLS N + G+ +LC+ L +P C L+ +
Sbjct: 745 QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
Query: 937 RLKTYETNLEIKKLLEEVKEKNPKL 961
+L+ + + + V NP L
Sbjct: 805 QLRKCQLESGACQEMASVLGTNPHL 829
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 410 bits (1055), Expect = e-114
Identities = 321/1014 (31%), Positives = 472/1014 (46%), Gaps = 110/1014 (10%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N E + E E
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEG-------------------------- 698
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
+ L++ Q L SS C H C L D L
Sbjct: 699 -------RHLDMVQCVLPSSS-HAACSHGL-GRCGLSH---------ECCFDISLVLSSN 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
+ L L L+ + + + L LC L++ CNL+ L L C T + VL + S
Sbjct: 741 QKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHS 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L L + N L D G +L + P+ LQ L L N LT C L++VL ++ LTH
Sbjct: 800 LTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
L L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L + SL L L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 911 SINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
N + G+ + C+ L+ +C L++L L N E K LE ++E+ P+LT+
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 409 bits (1051), Expect = e-114
Identities = 323/1014 (31%), Positives = 481/1014 (47%), Gaps = 110/1014 (10%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N M E + E + +L + C L
Sbjct: 670 IENCHRVESLSLG-----FLHN-MPKEEEEEEKEGRHLDMVQ---------------CVL 708
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
SS+ + S ++ H+T S C R
Sbjct: 709 PSSSH------------AACSHGLVNSHLTSSFC----------------RGLFSVLSTS 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
++LT L L+ + + M + LC+ L++ CN++ L LG + E + VL +NQ
Sbjct: 741 QSLTELDLSDNSLGDPGMRV-LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L L LS N L D G LL + L+ L L N LT C L++VL ++ LTH
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
L L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L + SL L L
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 911 SINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
N + G+ + C+ L+ +C L++L L N E K LE ++E+ P+LT+
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTV 973
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 396 bits (1018), Expect = e-110
Identities = 297/1007 (29%), Positives = 480/1007 (47%), Gaps = 105/1007 (10%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
LQ L +L+++E ++FK LL E P E+E A+ + LA +L +
Sbjct: 65 LQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGASLAWA 124
Query: 70 ATVNILEEMNLTELCKMAKAEMM----EDGQVQEIDN-------PELGDA-EEDS----- 112
+++I E MNL L + A+ +M ED + D P + A ++DS
Sbjct: 125 TSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEKVPGISQAVQQDSATAAE 184
Query: 113 ----ELAKPGEKEGWR----------NSMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFI 158
E+++ E+EG +ME++ T QG + D + +F
Sbjct: 185 TKEQEISQAMEQEGATAAETEEQEISQAMEQEGATAAETEEQGHGGDTWDYKSHVMTKFA 244
Query: 159 PFLNPRTPRKLT----------------------PYTVVLHGPAGVGKTTLAKKCMLDWT 196
+ R + T P TVVLHG +G+GK+ LA++ +L W
Sbjct: 245 EEEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVVLHGKSGIGKSALARRIVLCWA 304
Query: 197 DCNLSPTL-RYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGL 255
L + Y F+L +E+ R S E IS++WP+ Q + I+++ +R+LF++DG
Sbjct: 305 QGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDSQAPVTEIMSRPERLLFIIDGF 364
Query: 256 DELKVPPGALIQD---ICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLL 312
D+L G+++ + +C DW +K+P L+ SLL++ +LP + L+VT R L+
Sbjct: 365 DDL----GSVLNNDTKLCKDWAEKQPPFTLIRSLLRKVLLPESFLIVTVRDVGTEKLKSE 420
Query: 313 AQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTT 372
P Y+ V G E R L E Q + + +N L PAV ++C
Sbjct: 421 VVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNRELLDQCQVPAVGSLICVA 480
Query: 373 LKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-------QLRGALRTLSLLAAQGLW 424
L+LQ GE P T TGL F+ + P+G + R L+ +A +G+W
Sbjct: 481 LQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNLEERVVLKRFCRMAVEGVW 540
Query: 425 AQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEK 484
+ SVF +DL G+ ES+LR +IL D + Y+F HLS Q F AL+Y LE
Sbjct: 541 NRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTFFHLSLQDFCAALYYVLEG 600
Query: 485 EEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVG---------HFLFGLANEKRAKELE 535
E I L E+ ++ +L Q G FLFGL +E + LE
Sbjct: 601 LE----------IEPALCPLYVEKTKRSMELKQAGFHIHSLWMKRFLFGLVSEDVRRPLE 650
Query: 536 ATFGCRMSPDIKQELLQCKAHLHANKPLSVT--DLKEVLGCLYESQEEELAKVVVAPFKE 593
GC + +KQ+LL + L +P + T D + CL+E+Q++E ++ + F+E
Sbjct: 651 VLLGCPVPLGVKQKLLHWVSLL-GQQPNATTPGDTLDAFHCLFETQDKEFVRLALNSFQE 709
Query: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
+ + + +++ SF L+HC L+K+ + V KG+F D E C +P W
Sbjct: 710 VWLPINQNLDLIASSFCLQHCPYLRKIRVDV-KGIFPR-------DESAEACP--VVPLW 759
Query: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
R W DFCS+ ++ +L+ L++ S L++ +++ LC + TC +Q + +N
Sbjct: 760 MRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFRN 819
Query: 714 VTPDTAYRDFCLAFIGKKTLTHLTLAG-HIEWERTMMLMLCDLLRNHKCNLQYLRLGGHC 772
+ + + L L L G H++ E M C+ L++ KC L+ LRL
Sbjct: 820 AQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMA--CEALKHPKCLLESLRLDCCG 877
Query: 773 ATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTE 832
T + + +L + SLK L L+ N + D+G M L + + LQ L LE+C +T
Sbjct: 878 LTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITA 937
Query: 833 ASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGC 892
C+ LA+ LV ++ LTHLCL+ N +G+ GV LC + P C LQ L+L QC + GC
Sbjct: 938 TGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGC 997
Query: 893 RYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
+L+ AL LT+L LS+N + G+ +LC+ + P+C+L+ L L
Sbjct: 998 GFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
Score = 139 bits (349), Expect = 2e-32
Identities = 110/321 (34%), Positives = 158/321 (49%), Gaps = 18/321 (5%)
Query: 658 LRSLRLWTDFCSL-----------FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHL 706
L SLRL D C L +++ +LK L + + ++D V L D + S C L
Sbjct: 868 LESLRL--DCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCAL 925
Query: 707 QKVEIKNV-TPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQY 765
QK+ +++ T + A + ++LTHL L+ + + L LC +R C+LQ
Sbjct: 926 QKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNL-LCRSMRLPHCSLQR 984
Query: 766 LRLGGHCATPEQWAEFFYV-LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLS 824
L L C F + L N L HL LS N + D G LL + M P LQ L
Sbjct: 985 LMLN-QCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLE 1043
Query: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L C LT A C+ L+ V+ S+ L L L N +GD GV LCEGL + L L L+
Sbjct: 1044 LVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKA 1103
Query: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYET 943
C +T C LS AL LT+L+L N + +G+ LC A P NL+ + L ++
Sbjct: 1104 CGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQY 1163
Query: 944 NLEIKKLLEEVKEKNPKLTID 964
++I+KLLEEV+ P++ ID
Sbjct: 1164 PVQIRKLLEEVQLLKPRVVID 1184
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 359 bits (922), Expect = 6e-99
Identities = 292/934 (31%), Positives = 426/934 (45%), Gaps = 109/934 (11%)
Query: 10 LQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRN 69
L LE L + +LK FK L +P + P + E+AD LA ++++ + E
Sbjct: 10 LARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWA 69
Query: 70 ATVNILEEMNLTELCKMAKAEMMEDG-------------QVQEIDNPELGDAEEDSELAK 116
V I +N +L + AK + + G Q I+ +G E S ++
Sbjct: 70 MAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISI 129
Query: 117 PGEKEGWRNSMEK-----------------QSLVWKNTFWQGDIDNFHDDVTLRNQRFIP 159
K+ +R K +S+ + + + H R Q +
Sbjct: 130 CKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLA 189
Query: 160 F------LNPRTPRKLT------------PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL- 200
+P +P K+ +TVV G AG+GKT LA+K MLDW L
Sbjct: 190 IGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLY 249
Query: 201 SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKV 260
Y FY+ C+E+S + S +LI P+ I I+ + RILF++DG DEL+
Sbjct: 250 QDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQG 309
Query: 261 PPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVR 320
I +C DW+K + +LL SL+++K+LP A+LL+TTRP AL LQ L P +V
Sbjct: 310 AFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVE 369
Query: 321 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 380
+ GF E R+ YF ++F DE QA AF L++ N LF + P VCWIVCT LK QME G
Sbjct: 370 ILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESG 429
Query: 381 EDPVPTCLTRTGLFLRFLCSRF-PQGAQ----LRGALRTLSLLAAQGLWAQMSVFHREDL 435
+ T T T +++ FL S P+G L L L LAA G+W Q +F DL
Sbjct: 430 KSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKILFEESDL 489
Query: 436 ERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYALEKE-EGEDR-DGH 493
G+Q++D+ FL ++ +++ + YSFIH++FQ+F A++Y LE+E EG G
Sbjct: 490 RNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGS 549
Query: 494 AWDIG--DVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELL 551
+ DV LL + + LI V FLFGL N++R LE C++S I+ ELL
Sbjct: 550 RLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELL 609
Query: 552 QCKAHLHANKPLSVTDLK-EVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFS 610
+ K L + + E+ CLYE QEE+ + + F +I I+L+ + M SF
Sbjct: 610 KWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFC 669
Query: 611 LKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSL 670
+++C ++ LSL FL N E + E E
Sbjct: 670 IENCHRVESLSLG-----FLHNMPKEEEEEEKEG-------------------------- 698
Query: 671 FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGK 730
+ L++ Q L SS C H C L D L
Sbjct: 699 -------RHLDMVQCVLPSSS-HAACSHGL-GRCGLSH---------ECCFDISLVLSSN 740
Query: 731 KTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQS 790
+ L L L+ + + + L LC L++ CNL+ L L T + VL NQ+
Sbjct: 741 QKLVELDLSDNALGDFGIRL-LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQN 799
Query: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
L HL L N L D+G LL + + P LQ+L L+NC LT C DL+ +L S+ L
Sbjct: 800 LTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRK 859
Query: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L L N +GD GV CE L C LQ L L +
Sbjct: 860 LSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 122 bits (307), Expect = 1e-27
Identities = 74/181 (40%), Positives = 100/181 (55%), Gaps = 1/181 (0%)
Query: 784 VLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLV 843
VL +NQ L L LS N L D G LL + L+ L L N LT C L++VL
Sbjct: 736 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLS 795
Query: 844 VSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEAC 903
++ LTHL L N +GD G+K LCEGL +PDCKLQ L L C++T C LS L +
Sbjct: 796 TNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQ 855
Query: 904 SLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLT 962
SL L L N + G+ + C+ L+ +C L++L L N E K LE ++E+ P+LT
Sbjct: 856 SLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELT 915
Query: 963 I 963
+
Sbjct: 916 V 916
Score = 74.3 bits (181), Expect = 5e-13
Identities = 42/115 (36%), Positives = 65/115 (56%), Gaps = 1/115 (0%)
Query: 825 LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQ 884
L C L+ C D++ VL ++KL L L+ N +GD G++ LC GL + C L+ L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 885 CSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
+T + C LS L +LT+L L N + +G+ +LC+ L +P+C L+ L L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLEL 834
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 316 bits (809), Expect = 8e-86
Identities = 251/743 (33%), Positives = 362/743 (48%), Gaps = 107/743 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKLQTLVLQQCSIT 888
LCEGL +P CKL L L Q +++
Sbjct: 942 LCEGLRHPACKLIRLGLDQTTLS 964
Score = 120 bits (302), Expect = 5e-27
Identities = 73/191 (38%), Positives = 101/191 (52%), Gaps = 1/191 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLE 952
L+ L + SL LDL N + G+ +LC+ L +P C L L L + E+++ L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
Query: 953 EVKEKNPKLTI 963
++++ P+L I
Sbjct: 973 ALEQEKPQLLI 983
Score = 72.4 bits (176), Expect = 2e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 KLLEEVKEKNPKL 961
+ L V +P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 316 bits (809), Expect = 8e-86
Identities = 251/743 (33%), Positives = 362/743 (48%), Gaps = 107/743 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKLQTLVLQQCSIT 888
LCEGL +P CKL L L Q +++
Sbjct: 942 LCEGLRHPACKLIRLGLDQTTLS 964
Score = 120 bits (302), Expect = 5e-27
Identities = 73/191 (38%), Positives = 101/191 (52%), Gaps = 1/191 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLE 952
L+ L + SL LDL N + G+ +LC+ L +P C L L L + E+++ L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
Query: 953 EVKEKNPKLTI 963
++++ P+L I
Sbjct: 973 ALEQEKPQLLI 983
Score = 72.4 bits (176), Expect = 2e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 KLLEEVKEKNPKL 961
+ L V +P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 316 bits (809), Expect = 8e-86
Identities = 251/743 (33%), Positives = 362/743 (48%), Gaps = 107/743 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKLQTLVLQQCSIT 888
LCEGL +P CKL L L Q +++
Sbjct: 942 LCEGLRHPACKLIRLGLDQTTLS 964
Score = 120 bits (302), Expect = 5e-27
Identities = 73/191 (38%), Positives = 101/191 (52%), Gaps = 1/191 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLE 952
L+ L + SL LDL N + G+ +LC+ L +P C L L L + E+++ L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELR 972
Query: 953 EVKEKNPKLTI 963
++++ P+L I
Sbjct: 973 ALEQEKPQLLI 983
Score = 72.4 bits (176), Expect = 2e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 KLLEEVKEKNPKL 961
+ L V +P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 315 bits (808), Expect = 1e-85
Identities = 267/951 (28%), Positives = 424/951 (44%), Gaps = 71/951 (7%)
Query: 3 SPQLEWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTS 62
S ++ L LE L++ E +SFK L L+ L + P ++ + ++LA +L +
Sbjct: 4 SDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLPISY 60
Query: 63 SENWIRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEG 122
+I N +I M +LC+ +G + E K +
Sbjct: 61 EGQYIWNMLFSIFSMMRKEDLCRKI-----------------IGRRNRNQEACKAVMRR- 102
Query: 123 WRNSMEKQSLVWKN-TFWQGDIDNFHD---DVTLRNQRFIPFLNPRTPRKLTPYTVVLHG 178
K L W++ TF + F D DV Q + + L V L G
Sbjct: 103 ------KFMLQWESHTFGKFHYKFFRDVSSDVFYILQLAYDSTSYYSANNLN---VFLMG 153
Query: 179 PAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDD 237
GKT + +L W + + Y +L+ E+++M S AELI+KDWP+ Q
Sbjct: 154 ERASGKTIVINLAVLRWIKGEMWQNMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAP 213
Query: 238 IPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAAL 297
I IL+ +++LF+++ LD ++ +C + +K P+PVLL SLLKRKM P
Sbjct: 214 IADILSDPKKLLFILEDLDNIRFELNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWF 273
Query: 298 LVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALF 357
L+++RP +++ ++ R YF F D +A A +L+ + L
Sbjct: 274 LISSRPTRGNNVKTFLKEVDCCTTLQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILV 333
Query: 358 QLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFPQGAQLR------GA 411
L +CWI CT LK QM+KG D C T T L FL A L G
Sbjct: 334 GLCRVAILCWITCTVLKRQMDKGRDFQLCCQTPTDLHAHFLADALTSEAGLTANQYHLGL 393
Query: 412 LRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSF 471
L+ L LLAA GL+ F EDL +G E+D+ + +IL K Y FIHL+
Sbjct: 394 LKRLCLLAAGGLFLSTLNFSGEDLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNV 453
Query: 472 QQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRA 531
Q+F TA+ + + G E+R + D QV F+FGL N R
Sbjct: 454 QEFCTAIAFLMAVPNYLIPSG---------SREYKEKREQYSDFNQVFTFIFGLLNANRR 504
Query: 532 KELEATFGCR--MSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVA 589
K LE +FG + M K + HL + P +T + CLYE++EEE K +V
Sbjct: 505 KILETSFGYQLPMVDSFKWYSVGYMKHLDRD-PEKLTHHMPLFYCLYENREEEFVKTIVD 563
Query: 590 PFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLT 649
E++++L + ++M + L +C L+ L L V + F+ L
Sbjct: 564 ALMEVTVYLQSDKDMMVSLYCLDYCCHLRTLKLSVQR--------------IFQNKEPLI 609
Query: 650 IPNWARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKV 709
P ++SL W + CSLF + +L+ L + + L+ S RIL + S+C L+ +
Sbjct: 610 RP--TASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTL 667
Query: 710 EIKNVTPDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLG 769
++ V+ + + D A ++LT+L++ M +L D+L C + +L L
Sbjct: 668 KLSYVSTASGFEDLLKALARNRSLTYLSI-NCTSISLNMFSLLHDILHEPTCQISHLSLM 726
Query: 770 GHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCR 829
+ E +L + SL+ L LS+N L +G +L + P L L L C
Sbjct: 727 KCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCC 786
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
LTE C L VL+ S L L L N + + GV + L +P C+L+ L L C +
Sbjct: 787 LTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSS 846
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
C+Y++ + L +L++ N+I G+ +LC L +PNC L ++ L+
Sbjct: 847 DICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLE 897
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 312 bits (800), Expect = 9e-85
Identities = 248/732 (33%), Positives = 356/732 (48%), Gaps = 107/732 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKL 877
LCEGL +P CKL
Sbjct: 942 LCEGLRHPACKL 953
Score = 112 bits (280), Expect = 2e-24
Identities = 67/164 (40%), Positives = 86/164 (52%), Gaps = 1/164 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHL 936
L+ L + SL LDL N + G+ +LC+ L +P C L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 72.4 bits (176), Expect = 2e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 KLLEEVKEKNPKL 961
+ L V +P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 312 bits (800), Expect = 9e-85
Identities = 248/732 (33%), Positives = 356/732 (48%), Gaps = 107/732 (14%)
Query: 157 FIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL 215
F P L+ + PR V+L G AG+GK+TLA++ W L ++ FY SC+EL
Sbjct: 318 FGPGLDTQEPR-----IVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCREL 372
Query: 216 SRMGPCSFAELISKDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQD----ICG 271
++ S AELI KD I IL++ +R+LF++DG+DE PG ++Q+ +C
Sbjct: 373 AQSKVVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDE----PGWVLQEPSSELCL 428
Query: 272 DWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRA 331
W + +P LLGSLL + +LP A+ L+T R AL++L +Q +V V GF E R+
Sbjct: 429 HWSQPQPADALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKE 488
Query: 332 YFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRT 391
YF R+F DE QA+RAF L++SN L+ L P V W+ CT L QM++ E T T T
Sbjct: 489 YFYRYFTDERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTT 548
Query: 392 GLFLRFLCSRFPQGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDG 451
L L +L Q L LR L LAA+G+W + ++F +DL + G+ + + FL
Sbjct: 549 TLCLHYLAQAL-QAQPLGPQLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKM 607
Query: 452 DILRQDRVSKGCYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLS--GEER 509
IL++ + YSFIHL FQ+F A+ Y LE E+G R H+ I D++K L G
Sbjct: 608 GILQEHPIPLS-YSFIHLCFQEFFAAMSYVLEDEKG--RGKHSNCIIDLEKTLEAYGIHG 664
Query: 510 LKNPDLIQVGHFLFGLANEKRAKELEATFGCRMSPDIKQELLQCKAHLHAN-KPLSVTDL 568
L + FL GL +++ +E+E F CR+S + L+Q L +P S+
Sbjct: 665 LFGASTTR---FLLGLLSDEGEREMENIFHCRLSQG--RNLMQWVPSLQLLLQPHSL--- 716
Query: 569 KEVLGCLYESQEEELAKVVVAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
E L CLYE++ + V+A F+E+
Sbjct: 717 -ESLHCLYETRNKTFLTQVMAHFEEMG--------------------------------- 742
Query: 629 FLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSN-SNLKFLEVKQSFL 687
M E D+E CT FC FS + L+ +E +Q
Sbjct: 743 -----MCVETDMELLVCT--------------------FCIKFSRHVKKLQLIEGRQH-- 775
Query: 688 SDSSVRILCDHVTRSTCHLQKVEIKNVTPDT-AYRDFCLAFIG-KKTLTHLTLAGHIEWE 745
RST V + P T AY + + + L L L+G+
Sbjct: 776 -------------RSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGN-SLS 821
Query: 746 RTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEG 805
+ + LC LR +C L+ LRL G T E + + L+ANQ+L L LS NVL D G
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAG 881
Query: 806 AMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKF 865
A L + + +P LQ L L +C LT C+DLA+VL S L L L +N + D GV+
Sbjct: 882 AKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRL 941
Query: 866 LCEGLSYPDCKL 877
LCEGL +P CKL
Sbjct: 942 LCEGLRHPACKL 953
Score = 112 bits (280), Expect = 2e-24
Identities = 67/164 (40%), Positives = 86/164 (52%), Gaps = 1/164 (0%)
Query: 774 TPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEA 833
T W F VLK ++LK L LS N L L KT+ RP+ L+ L L C LT
Sbjct: 793 TDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAE 852
Query: 834 SCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCR 893
CKDLA L ++ LT L L+ N + D G K LC+ L P CKLQ L L C +T C+
Sbjct: 853 DCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQ 912
Query: 894 YLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHL 936
L+ L + SL LDL N + G+ +LC+ L +P C L L
Sbjct: 913 DLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 72.4 bits (176), Expect = 2e-12
Identities = 47/133 (35%), Positives = 71/133 (53%), Gaps = 1/133 (0%)
Query: 830 LTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITK 889
+T+A + L +VL V++ L L L+ N + + VK LC+ L P C L+TL L C +T
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 890 LGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIK 948
C+ L+ L+ +LT LDLS N + G LCQ L P+C L+ L+L + +
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 949 KLLEEVKEKNPKL 961
+ L V +P L
Sbjct: 912 QDLASVLSASPSL 924
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 244 bits (623), Expect = 3e-64
Identities = 225/726 (30%), Positives = 325/726 (44%), Gaps = 77/726 (10%)
Query: 171 PYTVVLHGPAGVGKTTLAKKCMLDWTDCNL-SPTLRYAFYLSCKEL-SRMGPCSFAELIS 228
P TVVL GPAG+GKT AKK + DW L + +AF++ C EL R G S A+LI
Sbjct: 195 PLTVVLQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLIL 254
Query: 229 KDWPELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLK 288
P+ +P +LAQ QR+LF++DG DEL G +E VL G LL
Sbjct: 255 DQCPDRGAPVPQMLAQPQRLLFILDGADELPALGGPEAAPCTDPFEAASGARVL-GGLLS 313
Query: 289 RKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFE 348
+ +LP A LLVTTR A LQ P V GF ++D++ YF + F DE +A RA+
Sbjct: 314 KALLPTALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYR 373
Query: 349 LMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCS-----RFP 403
++ N LF L P VCWIVCT L+ Q+E G D T T T ++L F+ S
Sbjct: 374 FVKENETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVA 433
Query: 404 QGAQLRGALRTLSLLAAQGLWAQMSVFHREDLERLGVQESDLR-LFLDGDILRQDRVSKG 462
G +L+G LR L LA +G+ + + F ++LE+L ++ S ++ LFL L ++
Sbjct: 434 DGPRLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEV 493
Query: 463 CYSFIHLSFQQFLTALFYALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFL 522
Y FI SFQ+FL AL Y LE + G R G V LL G+ + + L+ FL
Sbjct: 494 TYQFIDQSFQEFLAALSYLLE-DGGVPRTA----AGGVGTLLRGDAQ-PHSHLVLTTRFL 547
Query: 523 FGLANEKRAKELEATFGCRMSPDIKQELLQ------------CKAHLHANKPLSVTDLK- 569
FGL + +R +++E FGC +S +KQE L+ K L T+
Sbjct: 548 FGLLSAERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPE 607
Query: 570 ------------EVLGCLYESQEEELAKVVVAPFKEISIHLTN--TSEVMHCSFSLKHCQ 615
E+L CLYE+QE+ + + F E+++ +V S+ ++ C
Sbjct: 608 EEEEGEEPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCP 667
Query: 616 DLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNWARQDLRSLRLWTDFCSLFSSNS 675
Q L L C + ++ L RL SS
Sbjct: 668 AGQALRL--------------------ISCRLVAAQEKKKKSL-GKRLQASLGGGSSSQG 706
Query: 676 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFCLAFIGKKTLT 734
K L S + L +T CHL + + + PD RD A LT
Sbjct: 707 TTKQLPA-------SLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALT 759
Query: 735 HLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY-VLKANQSLKH 793
L L H + ML + L +C +Q +R+ P++ ++ +L+ + +L
Sbjct: 760 ELGLL-HNRLSEAGLRMLSEGLAWPQCRVQTVRV--QLPDPQRGLQYLVGMLRQSPALTT 816
Query: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKL--THL 851
L LS L L + LQ LSL + L+E S ++L AV L TH
Sbjct: 817 LDLSGCQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHP 876
Query: 852 CLAKNP 857
L +P
Sbjct: 877 ALDGHP 882
Score = 92.0 bits (227), Expect = 2e-18
Identities = 60/168 (35%), Positives = 93/168 (55%), Gaps = 3/168 (1%)
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
L++ MT P L L+L +C+L +A C+DL+ L + LT L L N + + G++ L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL++P C++QT V Q + G +YL L+++ +LT LDLS Q+ A + LC L+
Sbjct: 779 GLAWPQCRVQT-VRVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 928 NPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTIDCNA-SGATAPP 974
+ C L+ L L + E + + + L+ VK P L I A G PP
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVITHPALDGHPQPP 885
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 219 bits (557), Expect = 1e-56
Identities = 181/621 (29%), Positives = 287/621 (46%), Gaps = 52/621 (8%)
Query: 14 LEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENWIRNATVN 73
L L E++ K K L L + E+E LAE+L++ E +
Sbjct: 17 LSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLK 76
Query: 74 ILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKE-----GWRNSME 128
L+ MNL EL + D +E+ + EE E G +S
Sbjct: 77 GLKVMNLLELVDQLSHICLHD--YREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSES 134
Query: 129 KQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKTTLA 188
+SL F + ++++ VT+ + L P VVL G AG GKTTLA
Sbjct: 135 PESLACP--FPEQELES----VTVE-----ALFDSGEKPSLAPSLVVLQGSAGTGKTTLA 183
Query: 189 KKCMLDWTDCNLSP-TLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQAQR 247
+K +LDW L P Y FY+SCKE+ + +L+ + Q + IL Q +R
Sbjct: 184 RKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPER 243
Query: 248 ILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRPRALR 307
+LF++DG DEL+ P ++ P LL L++R LP +LL+TTRP ALR
Sbjct: 244 LLFILDGFDELQRPFEEKLKK-----RGLSPKESLLHLLIRRHTLPTCSLLITTRPLALR 298
Query: 308 DLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCW 367
+L+ L +Q +V + GF EE+R YF +F DE QA RAF++++ N L++ P +CW
Sbjct: 299 NLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICW 358
Query: 368 IVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP-------QGAQLRGALRTLSLLAA 420
+VC+ L+ QME+G+ + T T +F+ ++ + P LR+L LAA
Sbjct: 359 VVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAA 418
Query: 421 QGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFY 480
+G+ Q +F +L + + L FL + + K YSF H+SFQ F A+ Y
Sbjct: 419 EGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSY 478
Query: 481 ALEKEEGEDRDGHAWDIGDVQKLLSGEERLKNPDLIQVGHFLFGLANEKRAKELEATFGC 540
+ +E + R G +VQ+LL +E+ N ++ FL ++ + LE F
Sbjct: 479 LV--KEDQSRLGKE-SRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCF 535
Query: 541 RMSPDIKQELLQCKAHLHANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKEISIHLTN 600
R+SP + Q+L K + + K DL+ LYE++ + L K +
Sbjct: 536 RISPCLAQDLKHFKEQMESMKHNRTWDLE---FSLYEAKIKNLVKGI------------- 579
Query: 601 TSEVMHCSFSLKHCQDLQKLS 621
++ + SF +KH + + S
Sbjct: 580 --QMNNVSFKIKHSNEKKSQS 598
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 135 bits (339), Expect = 2e-31
Identities = 93/249 (37%), Positives = 128/249 (51%), Gaps = 2/249 (0%)
Query: 718 TAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQ 777
+A D A I K LT + L+G+ MML LC+ LR+ +C LQ ++L
Sbjct: 40 SACEDLSAALIANKNLTRMDLSGNGVGFPGMML-LCEGLRHPQCRLQMIQLRKCQLESGA 98
Query: 778 WAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKD 837
E VL N L L L+ N L D G LL + + P L+ L L+ CRLT A+C +
Sbjct: 99 CQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDE 158
Query: 838 LAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSE 897
LA+ L V++ L L L+ N +GD GV LCEGL +P CKLQTL L C +T C L
Sbjct: 159 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYF 218
Query: 898 ALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKE 956
L +LT+L L+ N + G+ +LC+ L +P C L+ L L + N L ++
Sbjct: 219 TLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRV 278
Query: 957 KNPKLTIDC 965
P L I C
Sbjct: 279 TKPYLDIGC 287
Score = 109 bits (273), Expect = 1e-23
Identities = 77/244 (31%), Positives = 119/244 (48%), Gaps = 13/244 (5%)
Query: 659 RSLRLWTDFCSLFSS-----------NSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ 707
R RLW C + SS N NL +++ + + + +LC+ + C LQ
Sbjct: 26 RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQ 85
Query: 708 KVEIKNVTPDTAYRDFCLAFIGKKT-LTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYL 766
++++ ++ + +G L L L G+ E + +LC LR+ C L+ L
Sbjct: 86 MIQLRKCQLESGACQEMASVLGTNPHLVELDLTGN-ALEDLGLRLLCQGLRHPVCRLRTL 144
Query: 767 RLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLE 826
L T E L NQSL+ L LS N L D G +LL + + P LQ L L+
Sbjct: 145 WLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLD 204
Query: 827 NCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCS 886
+C LT +C++L L +++ LT L L N +GDTGV+ LC+ LS+P CKL+ L L
Sbjct: 205 SCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMD 264
Query: 887 ITKL 890
+ K+
Sbjct: 265 LNKM 268
Score = 94.0 bits (232), Expect = 6e-19
Identities = 47/120 (39%), Positives = 74/120 (61%), Gaps = 1/120 (0%)
Query: 821 QMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTL 880
Q L L+ CR++ ++C+DL+A L+ +K LT + L+ N +G G+ LCEGL +P C+LQ +
Sbjct: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Query: 881 VLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLK 939
L++C + C+ ++ L L LDL+ N + GL +LCQ L +P C L+ L LK
Sbjct: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
Score = 64.7 bits (156), Expect = 4e-10
Identities = 54/188 (28%), Positives = 89/188 (47%), Gaps = 2/188 (1%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCL 725
+ S+ +N +L L++ + L D +R+LC + C L+ + +K A D
Sbjct: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELA 160
Query: 726 AFIG-KKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
+ + ++L L L+ + E +L+LC+ LR+ C LQ LRL T + ++
Sbjct: 161 STLSVNQSLRELDLSLN-ELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L NQ+L L L+ N L D G LL K ++ P L++L L L + + LAA+ V
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVT 279
Query: 845 SKKLTHLC 852
L C
Sbjct: 280 KPYLDIGC 287
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 127 bits (319), Expect = 5e-29
Identities = 93/298 (31%), Positives = 148/298 (49%), Gaps = 5/298 (1%)
Query: 669 SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLA 726
S+ + + K L V + ++++ VR+LC + S C L+ K+E VT D RD C
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGI 222
Query: 727 FIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLK 786
K +L L L G + M LC L + L+ L + T + + VL+
Sbjct: 223 VASKASLRELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 787 ANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSK 846
A +SLK L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 847 KLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLT 906
L L ++ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 907 NLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
LDLS N + G+ L +++ P C L+ L L + E++ L+ +++ P L +
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 112 bits (280), Expect = 2e-24
Identities = 78/277 (28%), Positives = 133/277 (48%), Gaps = 7/277 (2%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
L L +S N++ G+ LCQ L P L+ L L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 102 bits (253), Expect = 2e-21
Identities = 63/193 (32%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLKT 940
+ C L+ L+L++
Sbjct: 196 DSPCQLEALKLES 208
Score = 99.8 bits (247), Expect = 1e-20
Identities = 62/182 (34%), Positives = 91/182 (50%), Gaps = 1/182 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HL 936
L
Sbjct: 260 TL 261
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 127 bits (319), Expect = 5e-29
Identities = 93/298 (31%), Positives = 148/298 (49%), Gaps = 5/298 (1%)
Query: 669 SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLA 726
S+ + + K L V + ++++ VR+LC + S C L+ K+E VT D RD C
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGI 222
Query: 727 FIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLK 786
K +L L L G + M LC L + L+ L + T + + VL+
Sbjct: 223 VASKASLRELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 787 ANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSK 846
A +SLK L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 847 KLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLT 906
L L ++ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 907 NLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
LDLS N + G+ L +++ P C L+ L L + E++ L+ +++ P L +
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 112 bits (280), Expect = 2e-24
Identities = 78/277 (28%), Positives = 133/277 (48%), Gaps = 7/277 (2%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
L L +S N++ G+ LCQ L P L+ L L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 102 bits (253), Expect = 2e-21
Identities = 63/193 (32%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLKT 940
+ C L+ L+L++
Sbjct: 196 DSPCQLEALKLES 208
Score = 99.8 bits (247), Expect = 1e-20
Identities = 62/182 (34%), Positives = 91/182 (50%), Gaps = 1/182 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HL 936
L
Sbjct: 260 TL 261
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 127 bits (319), Expect = 5e-29
Identities = 93/298 (31%), Positives = 148/298 (49%), Gaps = 5/298 (1%)
Query: 669 SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLA 726
S+ + + K L V + ++++ VR+LC + S C L+ K+E VT D RD C
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGI 222
Query: 727 FIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLK 786
K +L L L G + M LC L + L+ L + T + + VL+
Sbjct: 223 VASKASLRELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 787 ANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSK 846
A +SLK L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 847 KLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLT 906
L L ++ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 907 NLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
LDLS N + G+ L +++ P C L+ L L + E++ L+ +++ P L +
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 112 bits (280), Expect = 2e-24
Identities = 78/277 (28%), Positives = 133/277 (48%), Gaps = 7/277 (2%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
L L +S N++ G+ LCQ L P L+ L L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 102 bits (253), Expect = 2e-21
Identities = 63/193 (32%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLKT 940
+ C L+ L+L++
Sbjct: 196 DSPCQLEALKLES 208
Score = 99.8 bits (247), Expect = 1e-20
Identities = 62/182 (34%), Positives = 91/182 (50%), Gaps = 1/182 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HL 936
L
Sbjct: 260 TL 261
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 127 bits (319), Expect = 5e-29
Identities = 93/298 (31%), Positives = 148/298 (49%), Gaps = 5/298 (1%)
Query: 669 SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLA 726
S+ + + K L V + ++++ VR+LC + S C L+ K+E VT D RD C
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGI 222
Query: 727 FIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLK 786
K +L L L G + M LC L + L+ L + T + + VL+
Sbjct: 223 VASKASLRELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 787 ANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSK 846
A +SLK L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 847 KLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLT 906
L L ++ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 907 NLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
LDLS N + G+ L +++ P C L+ L L + E++ L+ +++ P L +
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 112 bits (280), Expect = 2e-24
Identities = 78/277 (28%), Positives = 133/277 (48%), Gaps = 7/277 (2%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
L L +S N++ G+ LCQ L P L+ L L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 102 bits (253), Expect = 2e-21
Identities = 63/193 (32%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLKT 940
+ C L+ L+L++
Sbjct: 196 DSPCQLEALKLES 208
Score = 99.8 bits (247), Expect = 1e-20
Identities = 62/182 (34%), Positives = 91/182 (50%), Gaps = 1/182 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HL 936
L
Sbjct: 260 TL 261
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 127 bits (319), Expect = 5e-29
Identities = 93/298 (31%), Positives = 148/298 (49%), Gaps = 5/298 (1%)
Query: 669 SLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLA 726
S+ + + K L V + ++++ VR+LC + S C L+ K+E VT D RD C
Sbjct: 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGI 222
Query: 727 FIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLK 786
K +L L L G + M LC L + L+ L + T + + VL+
Sbjct: 223 VASKASLRELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
Query: 787 ANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSK 846
A +SLK L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++
Sbjct: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
Query: 847 KLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLT 906
L L ++ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL
Sbjct: 342 FLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLR 401
Query: 907 NLDLSINQIA-RGLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI 963
LDLS N + G+ L +++ P C L+ L L + E++ L+ +++ P L +
Sbjct: 402 ELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 112 bits (280), Expect = 2e-24
Identities = 78/277 (28%), Positives = 133/277 (48%), Gaps = 7/277 (2%)
Query: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
Query: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
Query: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
Query: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
Query: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRL 938
L L +S N++ G+ LCQ L P L+ L L
Sbjct: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
Score = 102 bits (253), Expect = 2e-21
Identities = 63/193 (32%), Positives = 98/193 (50%), Gaps = 11/193 (5%)
Query: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
Query: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
Query: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
Query: 928 NPNCNLKHLRLKT 940
+ C L+ L+L++
Sbjct: 196 DSPCQLEALKLES 208
Score = 99.8 bits (247), Expect = 1e-20
Identities = 62/182 (34%), Positives = 91/182 (50%), Gaps = 1/182 (0%)
Query: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Query: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
Query: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Query: 935 HL 936
L
Sbjct: 260 TL 261
Score = 89.7 bits (221), Expect = 1e-17
Identities = 65/218 (29%), Positives = 106/218 (48%), Gaps = 2/218 (0%)
Query: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNV-TPDTAYRDFC 724
D C + +S ++L+ L + + L D + LC + + L+ + I D C
Sbjct: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLC 277
Query: 725 LAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYV 784
K++L L+LAG+ E +LC+ L C L+ L + T + F V
Sbjct: 278 RVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
Query: 785 LKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVV 844
L N+ L L++S N L D G L + + +P L++L L +C ++++SC LAA L+
Sbjct: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
Query: 845 SKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
+ L L L+ N +GD G+ L E + P C L+ LVL
Sbjct: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Score = 48.9 bits (115), Expect = 2e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
Query: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
Query: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,740,545
Number of Sequences: 37866
Number of extensions: 1677875
Number of successful extensions: 5285
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 28
Number of HSP's that attempted gapping in prelim test: 4521
Number of HSP's gapped (non-prelim): 276
length of query: 980
length of database: 18,247,518
effective HSP length: 112
effective length of query: 868
effective length of database: 14,006,526
effective search space: 12157664568
effective search space used: 12157664568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.