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Search of human proteins with 74316006
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74316006 CNKSR family member 3 [Homo sapiens]
(555 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74316006 CNKSR family member 3 [Homo sapiens] 1128 0.0
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 576 e-164
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 181 2e-45
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 50 5e-06
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 50 5e-06
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 49 1e-05
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 46 1e-04
gi|93204861 protein phosphatase 1, regulatory (inhibitor) subuni... 45 1e-04
gi|148746189 multiple PDZ domain protein [Homo sapiens] 45 2e-04
gi|112382257 InaD-like [Homo sapiens] 45 2e-04
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 44 3e-04
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 42 0.001
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi... 42 0.001
gi|28557802 sterile alpha motif domain containing 14 [Homo sapiens] 42 0.001
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 40 0.006
gi|71274152 hypothetical protein LOC388939 [Homo sapiens] 39 0.010
gi|29294627 PTPRF interacting protein binding protein 1 isoform ... 39 0.012
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 39 0.016
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 39 0.016
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 38 0.021
gi|116284392 mucin 2 precursor [Homo sapiens] 37 0.062
gi|87196343 PDZ domain containing 2 [Homo sapiens] 37 0.062
gi|7706091 bifunctional apoptosis regulator [Homo sapiens] 35 0.14
gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo sa... 35 0.14
gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo sa... 35 0.14
gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo sap... 35 0.14
gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo sa... 35 0.14
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 35 0.18
gi|29789379 sphingomyelin synthase 1 [Homo sapiens] 35 0.18
gi|41393579 PDZ domain protein GIPC2 [Homo sapiens] 35 0.18
>gi|74316006 CNKSR family member 3 [Homo sapiens]
Length = 555
Score = 1128 bits (2918), Expect = 0.0
Identities = 555/555 (100%), Positives = 555/555 (100%)
Query: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE
Sbjct: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
Query: 61 LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF 120
LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF
Sbjct: 61 LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF 120
Query: 121 LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV 180
LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV
Sbjct: 121 LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV 180
Query: 181 LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT 240
LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT
Sbjct: 181 LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT 240
Query: 241 TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT 300
TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT
Sbjct: 241 TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT 300
Query: 301 PAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDEN 360
PAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDEN
Sbjct: 301 PAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDEN 360
Query: 361 GSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMR 420
GSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMR
Sbjct: 361 GSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMR 420
Query: 421 EKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSP 480
EKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSP
Sbjct: 421 EKTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGEDALCRYFSNERIPPIIEESSSP 480
Query: 481 PYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEP 540
PYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEP
Sbjct: 481 PYRFSRPTTERHLVRGADYIRGSRCYINSDLHSSATIPFQEEGTKKKSGSSATKSSSTEP 540
Query: 541 SLLVSWFTRLKLLTH 555
SLLVSWFTRLKLLTH
Sbjct: 541 SLLVSWFTRLKLLTH 555
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 576 bits (1484), Expect = e-164
Identities = 296/476 (62%), Positives = 358/476 (75%), Gaps = 9/476 (1%)
Query: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
MEPV+KWSP QVVDW +GLDDCLQQY+ FEREKI+G+QLL+I+HQ+LE+LGV+RIGHQE
Sbjct: 5 MEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQE 64
Query: 61 LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF 120
L+LEAVDLLCALNYGLET+N+K L KL AS+ NLQN+I+ RR+S YDG TSRK PN+F
Sbjct: 65 LILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDF 124
Query: 121 LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV 180
LTSVV+LIGAAK+LLAWLDR+PF +TD+SVT+N +IQLCL+LTT VQ+DC V E E+K+
Sbjct: 125 LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKI 184
Query: 181 LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT 240
L V K L+G+CD I ++DP++SQ A LE + L NIKP EGLGMYIKSTYDGLHVITGT
Sbjct: 185 LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGT 244
Query: 241 TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT 300
TENSPADR +KIHAGDEVIQVN QTVVGWQLKNLV LRE+P+GV+L LKKRP
Sbjct: 245 TENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKKRPQSMLTSA 304
Query: 301 PAPLKNLRWKP----PLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
PA LKN+RWKP PL+ S P ++ +P ST+ T K++ SA+ DLYIPPPPA PY P
Sbjct: 305 PALLKNMRWKPLALQPLIPRS-PTSSVATPSSTISTPTKRDSSALQDLYIPPPPAEPYIP 363
Query: 357 RDENGSFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILP 416
RDE G+ P KGSESPNSFLDQE R+R + + L Y E
Sbjct: 364 RDEKGNLPCEDLRGHMVGKPVHKGSESPNSFLDQEYRKRFNIVEEDTVLYCYEYEKGRSS 423
Query: 417 TK-MREKTPSYGKPRPLSMPADGNWMG-IVDPFARPRGHGRKGEDALCRYFSNERI 470
++ RE TP+YGK RP+SMP + NW+G DP R R E++L RY SNE+I
Sbjct: 424 SQGRRESTPTYGKLRPISMPVEYNWVGDYEDPNKMKRDSRR--ENSLLRYMSNEKI 477
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 181 bits (459), Expect = 2e-45
Identities = 129/391 (32%), Positives = 196/391 (50%), Gaps = 50/391 (12%)
Query: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
MEPV W+P +V W RGLDD LQ Y FE ++ G+ LLQ+ Q LE L V +GHQE
Sbjct: 1 MEPVETWTPGKVATWLRGLDDSLQDY--PFEDWQLPGKNLLQLCPQSLEALAVRSLGHQE 58
Query: 61 LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF 120
L+L V+ L AL+ L+T+N+++L L ++H+ Q+ + A K P +
Sbjct: 59 LILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCA-------KTPIDV 111
Query: 121 LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV 180
L + VEL+ A ALL WL R F+ + DFS + +I L +L+ + +D AE E V
Sbjct: 112 LCAAVELLHEADALLFWLSRYLFSHLNDFSACQ-EIRDLLEELSQVLHEDGPAAEKEGTV 170
Query: 181 LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT 240
L + + GIC + ++ Q A LE+V L + LG+ I +T + H ++
Sbjct: 171 LRICSHVAGICHNILVCCPKELLEQKAVLEQVQLDS-----PLGLEIHTTSNCQHFVSQV 225
Query: 241 TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT 300
P D +I GDEV+Q+N+Q VVGW KN+V++L P G+ L+LKK P
Sbjct: 226 DTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIP------- 278
Query: 301 PAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDEN 360
+ +PP Q+P +D+ ++ S L P P +P ++
Sbjct: 279 -------------IPETPP----QTPPQVLDSPHQRSPSLSL------APLSPRAPSED- 314
Query: 361 GSFVYGGSSKCKQPLPGPKGSESPNSFLDQE 391
F + SS P PGP + + ++ L E
Sbjct: 315 -VFAFDLSS---NPSPGPSPAWTDSASLGPE 341
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/61 (37%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Query: 3 PVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELV 62
PV W ++V W L C +Y F R I G +LL + +DL++LGVT++GH + +
Sbjct: 1097 PVHLWGTEEVAAWLEHLSLC--EYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRI 1154
Query: 63 L 63
L
Sbjct: 1155 L 1155
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/61 (37%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Query: 3 PVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELV 62
PV W ++V W L C +Y F R I G +LL + +DL++LGVT++GH + +
Sbjct: 1141 PVHLWGTEEVAAWLEHLSLC--EYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRI 1198
Query: 63 L 63
L
Sbjct: 1199 L 1199
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 48.9 bits (115), Expect = 1e-05
Identities = 22/65 (33%), Positives = 39/65 (60%), Gaps = 2/65 (3%)
Query: 2 EPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQEL 61
+PV KW ++V W L+ L +Y F R I G +LL + +DL++LG+ ++GH +
Sbjct: 1146 QPVQKWGTEEVAAWLDLLN--LGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGHVKR 1203
Query: 62 VLEAV 66
+L+ +
Sbjct: 1204 ILQGI 1208
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 45.8 bits (107), Expect = 1e-04
Identities = 37/125 (29%), Positives = 55/125 (44%), Gaps = 16/125 (12%)
Query: 218 KPGEGLGMYI---------KSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVG 268
K EG G I ST H I + SPADR K+ GD ++ VN Q+++
Sbjct: 926 KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIIN 985
Query: 269 WQLKNLVKKLRENPTGVVL-LLKKRPTGSFNFTPAPLKN--LRWKPPLVQTS----PPPA 321
++VK +++ V L ++ + S P+ K + + PL Q S P PA
Sbjct: 986 MPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQPSPA 1045
Query: 322 TTQSP 326
T SP
Sbjct: 1046 TPNSP 1050
Score = 35.4 bits (80), Expect = 0.14
Identities = 26/118 (22%), Positives = 47/118 (39%), Gaps = 2/118 (1%)
Query: 243 NSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPA 302
+ PA + K+ GD ++ +N+ V+G ++VK + P G + L F P
Sbjct: 458 DGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPE 517
Query: 303 PLKNLRWKPPLVQTSPPPATTQSPES--TMDTSLKKEKSAILDLYIPPPPAVPYSPRD 358
N P + PPP + T + + ++ D+ PP ++ P D
Sbjct: 518 DPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTD 575
Score = 30.4 bits (67), Expect = 4.4
Identities = 35/144 (24%), Positives = 59/144 (40%), Gaps = 24/144 (16%)
Query: 218 KPGEGLGMYIKSTYD---GLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNL 274
K +G G I+ + L+V+ E+ PA R+ ++ GD++I++N ++
Sbjct: 1152 KGAKGFGFSIRGGREYKMDLYVLR-LAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA 1210
Query: 275 VKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPE--STMDT 332
++ ++ V LLL KR TG + P +SP A PE ++D
Sbjct: 1211 IELIKSGGRRVRLLL-KRGTGQVP---------EYDEPAPWSSPAAAAPGLPEVGVSLDD 1260
Query: 333 SLKKEKSAILDLYIPPPPAVPYSP 356
L + P PA P P
Sbjct: 1261 GLAP--------FSPSHPAPPSDP 1276
Score = 29.3 bits (64), Expect = 9.9
Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 17/91 (18%)
Query: 255 GDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFN--FTPAPLKNLRWK-- 310
GD ++++NQQ V +V L++ P G L G F+ TP P+ + RW+
Sbjct: 643 GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMD-RWENQ 701
Query: 311 ---------PPLVQTSP-PPATTQS--PEST 329
P + Q P PPA +S P+ST
Sbjct: 702 GSPQTSLSAPAIPQNLPFPPALHRSSFPDST 732
>gi|93204861 protein phosphatase 1, regulatory (inhibitor) subunit 9A
[Homo sapiens]
Length = 1098
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/51 (45%), Positives = 32/51 (62%), Gaps = 2/51 (3%)
Query: 4 VTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVT 54
V +WS +QV W L+ L+QYV +F + I GEQLLQ+ L+ LG+T
Sbjct: 985 VQEWSVQQVSHWLMSLN--LEQYVSEFSAQNITGEQLLQLDGNKLKALGMT 1033
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 44.7 bits (104), Expect = 2e-04
Identities = 24/80 (30%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 213 HLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLK 272
H+ GLG+ +++T G H I P S K+ +GDE+++VN T++G +
Sbjct: 555 HVSKFSENSGLGISLEATV-GHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQ 613
Query: 273 NLVKKLRENPTGVVLLLKKR 292
++V L+E P V ++ +R
Sbjct: 614 DVVNILKELPIEVTMVCCRR 633
Score = 38.9 bits (89), Expect = 0.012
Identities = 32/149 (21%), Positives = 65/149 (43%), Gaps = 6/149 (4%)
Query: 209 LEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVG 268
++ + LP + G G+ + + T G+ +I TE+ A ++ GD+++ V+ + VVG
Sbjct: 1481 VQHLELPKDQGGLGIAISEEDTLSGV-IIKSLTEHGVAATDGRLKVGDQILAVDDEIVVG 1539
Query: 269 WQLKNLVKKLRENPTGVVLLL-KKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPE 327
+ ++ + L+ V L + + P + A + K P + + PE
Sbjct: 1540 YPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPE 1599
Query: 328 STMDTSLKKEKSAILDLYIPPPPAVPYSP 356
S +TS +S+ ++ P P P
Sbjct: 1600 SIRNTS----RSSTPAIFASDPATCPIIP 1624
Score = 33.9 bits (76), Expect = 0.40
Identities = 31/147 (21%), Positives = 62/147 (42%), Gaps = 16/147 (10%)
Query: 211 EVHLPNIKPGE-GLGMYIKSTYDGLHV---ITGTTENSPADRSQKIHAGDEVIQVNQQTV 266
E+H+ ++ G GLG+ + D + I G N A + ++ DE++++N Q +
Sbjct: 1347 ELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQIL 1406
Query: 267 VGWQLKNLVKKLRENPTGVVLLLKKR----------PTGSFNFTPAPLKNLRWK--PPLV 314
G +N ++ P+ V ++ + P + P+ +NL+ K P V
Sbjct: 1407 YGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTV 1466
Query: 315 QTSPPPATTQSPESTMDTSLKKEKSAI 341
TS S ++ L K++ +
Sbjct: 1467 TTSDAAVDLSSFKNVQHLELPKDQGGL 1493
Score = 31.6 bits (70), Expect = 2.0
Identities = 33/133 (24%), Positives = 63/133 (47%), Gaps = 17/133 (12%)
Query: 224 GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPT 283
G++IK HV+ E+SPA ++ + GD +++V+ + + V+ +R+
Sbjct: 1184 GIFIK------HVL----EDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGN 1233
Query: 284 GVVLLLK---KRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQ--SPESTMDTSLKKEK 338
VV +++ RP S P+ L NL K T+P + Q + ++ + + EK
Sbjct: 1234 PVVFMVQSIINRPRKS--PLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEK 1291
Query: 339 SAILDLYIPPPPA 351
+ + + PPP A
Sbjct: 1292 APLCSVPPPPPSA 1304
Score = 30.4 bits (67), Expect = 4.4
Identities = 43/198 (21%), Positives = 81/198 (40%), Gaps = 17/198 (8%)
Query: 148 DFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKVLTVVKVLNGICDKTIRSTTDPVMSQCA 207
D ++T + I + TVQ + V +V + TI + ++PV Q
Sbjct: 197 DQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVS-RSPSAASTISAHSNPVHWQH- 254
Query: 208 CLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVV 267
+E + L N G G G+ I G+ V T AD+ ++ +GD ++++ +
Sbjct: 255 -METIELVNDGSGLGFGI-IGGKATGVIVKT-ILPGGVADQHGRLCSGDHILKIGDTDLA 311
Query: 268 GWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPE 327
G + + + LR+ V L++ + R P + + + T +PE
Sbjct: 312 GMSSEQVAQVLRQCGNRVKLMIARGAIEE-----------RTAPTALGITLSSSPTSTPE 360
Query: 328 STMDTSLKK-EKSAILDL 344
+D S +K E+S D+
Sbjct: 361 LRVDASTQKGEESETFDV 378
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 44.7 bits (104), Expect = 2e-04
Identities = 40/156 (25%), Positives = 62/156 (39%), Gaps = 6/156 (3%)
Query: 194 TIRSTTDPVMSQCAC---LEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPADRSQ 250
T S D + + C +EEV L I G GLG I V+ ADR
Sbjct: 228 TSSSLNDTTLPETVCWGHVEEVEL--INDGSGLGFGIVGGKTSGVVVRTIVPGGLADRDG 285
Query: 251 KIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWK 310
++ GD ++++ V G + + + LR V +L+ + P G + TP L
Sbjct: 286 RLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISVTPPAPAALPVA 345
Query: 311 PPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYI 346
P V S P + S T + L ++ L + I
Sbjct: 346 LPTV-ASKGPGSDSSLFETYNVELVRKDGQSLGIRI 380
Score = 34.7 bits (78), Expect = 0.24
Identities = 32/148 (21%), Positives = 63/148 (42%), Gaps = 23/148 (15%)
Query: 214 LPNIKPGEGL-GMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLK 272
+ +K GE L G++IK E+SPA ++ + GD++++V+ +
Sbjct: 1090 IKRLKNGEELKGIFIKQVL----------EDSPAGKTNALKTGDKILEVSGVDLQNASHS 1139
Query: 273 NLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDT 332
V+ ++ VV +++ S + TP + N+ K + T + T +
Sbjct: 1140 EAVEAIKNAGNPVVFIVQ-----SLSSTPRVIPNVHNKANKI-------TGNQNQDTQEK 1187
Query: 333 SLKKEKSAILDLYIPPPPAVPYSPRDEN 360
K++ +A + +PPP DEN
Sbjct: 1188 KEKRQGTAPPPMKLPPPYKALTDDSDEN 1215
Score = 33.9 bits (76), Expect = 0.40
Identities = 20/70 (28%), Positives = 33/70 (47%), Gaps = 1/70 (1%)
Query: 223 LGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENP 282
LG+ + S +DG H I+ P D + DE+++VN + G + V L+E P
Sbjct: 570 LGVEVDS-FDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP 628
Query: 283 TGVVLLLKKR 292
L+ +R
Sbjct: 629 PPFTLVCCRR 638
Score = 33.1 bits (74), Expect = 0.68
Identities = 23/100 (23%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 211 EVHLPNI-KPGEGLGMYIKSTYDGLHV---ITGTTENSPADRSQKIHAGDEVIQVNQQTV 266
E+H+ + K GLG+ + D + + G PA ++ GDE++++N Q +
Sbjct: 1236 ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQIL 1295
Query: 267 VGWQLKNLVKKLRENPTGV--VLLLKKRPTGSFNFTPAPL 304
G +N ++ P+ V V + + TP P+
Sbjct: 1296 YGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335
Score = 30.8 bits (68), Expect = 3.4
Identities = 25/95 (26%), Positives = 42/95 (44%), Gaps = 3/95 (3%)
Query: 198 TTDPVMSQCACLEEVHLPNIKPGEGLGMYI---KSTYDGLHVITGTTENSPADRSQKIHA 254
+ DP +E+ + K GLG+ I K T VI E A R ++ A
Sbjct: 1422 SVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWA 1481
Query: 255 GDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLL 289
GD++++VN + + + LR+ P V L++
Sbjct: 1482 GDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVV 1516
Score = 30.4 bits (67), Expect = 4.4
Identities = 23/78 (29%), Positives = 35/78 (44%), Gaps = 6/78 (7%)
Query: 217 IKPGEGLGMYIKSTYDGLH------VITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQ 270
+K +GLG I D L VI + A+RS + GD ++ VN+ +
Sbjct: 690 VKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTS 749
Query: 271 LKNLVKKLRENPTGVVLL 288
L V+ L+ P G+V L
Sbjct: 750 LAEAVEILKAVPPGLVHL 767
>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
[Homo sapiens]
Length = 1849
Score = 44.3 bits (103), Expect = 3e-04
Identities = 23/68 (33%), Positives = 37/68 (54%), Gaps = 2/68 (2%)
Query: 2 EPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQEL 61
+PV W+ V DW L+ L ++ F +I+G L + +DL +LGVTR+GH+
Sbjct: 1781 KPVHLWTKPDVADWLESLN--LGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMN 1838
Query: 62 VLEAVDLL 69
+ A+ L
Sbjct: 1839 IERALKQL 1846
Score = 30.0 bits (66), Expect = 5.8
Identities = 35/166 (21%), Positives = 61/166 (36%), Gaps = 18/166 (10%)
Query: 204 SQCACLEEVHLPNIKPGEGLGMYIKST--------------YDGLHVITGTTENSPADRS 249
S C E+ + K EG G ++ + L + E A ++
Sbjct: 618 SDCIIEEKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQA 677
Query: 250 QKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRW 309
+ GD +I+VN + VV + +V +R+ +VL K T + N P +
Sbjct: 678 G-LRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVL---KVVTVTRNLDPDDTARKKA 733
Query: 310 KPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYS 355
PP + T +S T + +K+++ P VP S
Sbjct: 734 PPPPKRAPTTALTLRSKSMTSELEELVDKASVRKKKDKPEEIVPAS 779
Score = 29.6 bits (65), Expect = 7.6
Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 11/74 (14%)
Query: 314 VQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQ 373
+Q S P T P T+ E++ IL IPPPP D + F++ +
Sbjct: 1359 LQISAAPEPTTVPGRTIVAVGSMEEAVILPFRIPPPPLASV---DLDEDFIF------TE 1409
Query: 374 PLPGPKGSESPNSF 387
PLP P E NSF
Sbjct: 1410 PLPPP--LEFANSF 1421
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens]
Length = 1747
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/58 (36%), Positives = 32/58 (55%), Gaps = 2/58 (3%)
Query: 2 EPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQ 59
+P+ WS V DW + L ++ +FE +I G L ++ D ELGVTR+GH+
Sbjct: 1679 KPLQLWSKFDVGDWLESIH--LGEHRDRFEDHEIEGAHLPALTKDDFVELGVTRVGHR 1734
>gi|122937249 glutamate receptor interacting protein 2 [Homo
sapiens]
Length = 1141
Score = 42.4 bits (98), Expect = 0.001
Identities = 43/186 (23%), Positives = 75/186 (40%), Gaps = 14/186 (7%)
Query: 220 GEGLGMYIKSTYDGLH--VITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKK 277
G LG+ I T + VI+G T+ A+R+ IH GD ++ +N ++ G L +
Sbjct: 761 GGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNVSLKGRPLSEAIHL 820
Query: 278 LRENPTGVVLLLKK--------RPTGSFNFT----PAPLKNLRWKPPLVQTSPPPATTQS 325
L+ V L +KK R +GS + T P L+ P + SP + S
Sbjct: 821 LQVAGETVTLKIKKQLDRPLLPRKSGSLSETSDADEDPADALKGGLPAARFSPAVPSVDS 880
Query: 326 PESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSESPN 385
+ D+S + Y P A +P++ ++ G + + +
Sbjct: 881 AVESWDSSATEGGFGGPGSYTPQAAARGTTPQERRPGWLRGSPPPTEPRRTSYTPTPADE 940
Query: 386 SFLDQE 391
SF ++E
Sbjct: 941 SFPEEE 946
Score = 32.3 bits (72), Expect = 1.2
Identities = 49/208 (23%), Positives = 78/208 (37%), Gaps = 34/208 (16%)
Query: 219 PGEGLGMYIKSTY---DGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLV 275
PG LG+ + +T + I S DRS +H GD ++ ++ ++ L
Sbjct: 352 PGSALGISLTTTSLRNKSVITIDRIKPASVVDRSGALHPGDHILSIDGTSMEHCSLLEAT 411
Query: 276 KKLRENPTGVVLLLKKRPTGSFNFTP--------APLKNLRWKPPLVQT-SPPPATTQSP 326
K L V L + P P + RW P + SP P + P
Sbjct: 412 KLLASISEKVRLEILPVPQSQRPLRPQRQVVKVQRSEQLHRWDPCVPSCHSPRPGHCRMP 471
Query: 327 ESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDENGSFVYGGSSKCKQPLPGPKGSE--SP 384
T T +++S L + P+S N +F C P P+GS+ SP
Sbjct: 472 --TWATPAGQDQSRSLS-------STPFSSPTLNHAF------SCNNPSTLPRGSQPMSP 516
Query: 385 NSFLDQESRRRR-----FTIADSDQLPG 407
+ + + +RRR ++A S PG
Sbjct: 517 RTTMGRRRQRRREHKSSLSLASSTVGPG 544
>gi|28557802 sterile alpha motif domain containing 14 [Homo sapiens]
Length = 445
Score = 42.4 bits (98), Expect = 0.001
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
+ PV W+ +QV W + L+ L+QY +F +++G QLLQ+ L+ LG++ +
Sbjct: 348 LPPVHHWTSQQVGQWLQSLN--LEQYAAEFAARQVDGPQLLQLDGSKLKSLGLSNSHDRA 405
Query: 61 LV 62
LV
Sbjct: 406 LV 407
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 40.0 bits (92), Expect = 0.006
Identities = 17/54 (31%), Positives = 35/54 (64%)
Query: 23 LQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQELVLEAVDLLCALNYGL 76
L+ + FERE+I + L+++ H++L+E+G+ GH+ +++ V+ L + GL
Sbjct: 887 LEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGL 940
>gi|71274152 hypothetical protein LOC388939 [Homo sapiens]
Length = 1288
Score = 39.3 bits (90), Expect = 0.010
Identities = 48/189 (25%), Positives = 70/189 (37%), Gaps = 26/189 (13%)
Query: 310 KPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPY--------SPRDENG 361
+ P + S PPAT+QSPE T + EK+ LY P A+ + R
Sbjct: 918 RKPALDLSSPPATSQSPEVKGGTWSQAEKAT--SLYRQPRKAIAWHHSGPPSGQNRTSES 975
Query: 362 SFVYGGSSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMRE 421
S S+ + P G K S + ++ Q +RRR LP P+ ++
Sbjct: 976 SLARPRQSRERSPPVGRKASPTRTHWVPQADKRRR-------SLPSSYRPAQPSPSAVQT 1028
Query: 422 KTPSYGKPRPLSMPADGNWMGIVDPFARPRGHGRKGED--ALCRYFSNERIPPIIEESSS 479
PR LS P P +P+ E A C+ S PP +S
Sbjct: 1029 PPSPPVSPRVLSPPTTKR---RTSPPHQPKLPNPPPESAPAQCKVPS----PPTQHPEAS 1081
Query: 480 PPYRFSRPT 488
PP+ P+
Sbjct: 1082 PPFSIPSPS 1090
>gi|29294627 PTPRF interacting protein binding protein 1 isoform 1
[Homo sapiens]
Length = 1005
Score = 38.9 bits (89), Expect = 0.012
Identities = 26/77 (33%), Positives = 42/77 (54%), Gaps = 6/77 (7%)
Query: 3 PVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLE-ELGVTRIGHQ-- 59
P KW+ +QV +W ++ L Y++ + +G+ LLQ S QDLE ELG+ H+
Sbjct: 637 PFAKWTKEQVCNWL--MEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKK 694
Query: 60 -ELVLEAVDLLCALNYG 75
+L L+A+ N+G
Sbjct: 695 LQLALQALGSEEETNHG 711
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 38.5 bits (88), Expect = 0.016
Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 8/102 (7%)
Query: 218 KPGEGLGMYIKSTYD----GL--HVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQL 271
K EG G I ++ + G+ H I E SPADR K+ GD + VN Q++V
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 272 KNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPL 313
N+V+ +++ GV + L + P+ + R P L
Sbjct: 917 DNIVQLIKD--AGVTVTLTVIAEEEHHGPPSGTNSARQSPAL 956
Score = 32.3 bits (72), Expect = 1.2
Identities = 13/49 (26%), Positives = 28/49 (57%)
Query: 242 ENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLK 290
E+ PA + +IH GD+++++N + G ++ ++ V+LLL+
Sbjct: 1052 EDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 38.5 bits (88), Expect = 0.016
Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 8/102 (7%)
Query: 218 KPGEGLGMYIKSTYD----GL--HVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQL 271
K EG G I ++ + G+ H I E SPADR K+ GD + VN Q++V
Sbjct: 857 KENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSH 916
Query: 272 KNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPLKNLRWKPPL 313
N+V+ +++ GV + L + P+ + R P L
Sbjct: 917 DNIVQLIKD--AGVTVTLTVIAEEEHHGPPSGTNSARQSPAL 956
Score = 32.3 bits (72), Expect = 1.2
Identities = 13/49 (26%), Positives = 28/49 (57%)
Query: 242 ENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLK 290
E+ PA + +IH GD+++++N + G ++ ++ V+LLL+
Sbjct: 1052 EDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLR 1100
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens]
Length = 2161
Score = 38.1 bits (87), Expect = 0.021
Identities = 19/58 (32%), Positives = 33/58 (56%), Gaps = 2/58 (3%)
Query: 2 EPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQ 59
+P+ W+ V DW L L ++ +F +I+G L ++ +D +LGVTR+GH+
Sbjct: 2093 KPLGFWTKFDVADWLEWLG--LAEHRAQFLDHEIDGSHLPALTKEDYVDLGVTRVGHR 2148
>gi|116284392 mucin 2 precursor [Homo sapiens]
Length = 5179
Score = 36.6 bits (83), Expect = 0.062
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 12/57 (21%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
TP+P PP T+PPP TT SP +T S I PPP P SP
Sbjct: 1640 TPSP-------PPTTTTTPPPTTTPSPPTTTTPS-----PPITTTTTPPPTTTPSSP 1684
Score = 36.2 bits (82), Expect = 0.081
Identities = 46/180 (25%), Positives = 63/180 (35%), Gaps = 21/180 (11%)
Query: 194 TIRSTTDPVMS-------QCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGTTENSPA 246
T +TT P S + CL + P G + T+DG + G E+
Sbjct: 1282 TTTTTTTPTSSTVLSTTPKLCCLWSDWINEDHPSSGSDDGDRETFDG---VCGAPEDIEC 1338
Query: 247 DRSQKIHAGDEVI--QVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKR-----PTGSFNF 299
+ H E + +V VG+ KN + P G+ K R P
Sbjct: 1339 RSVKDPHLSLEQLGQKVQCDVSVGFICKN-EDQFGNGPFGLCYDYKIRVNCCWPMDKCIT 1397
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTS---LKKEKSAILDLYIPPPPAVPYSP 356
TP+P PP T+ PP TT SP +T T+ I PPP P P
Sbjct: 1398 TPSPPTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPP 1457
Score = 33.9 bits (76), Expect = 0.40
Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 12/57 (21%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
TP+P PP T+PPP TT SP +T S + PPP P P
Sbjct: 1561 TPSP-------PPTTTTTPPPTTTPSPPTTTTPS-----PPTITTTTPPPTTTPSPP 1605
Score = 33.9 bits (76), Expect = 0.40
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 14/58 (24%)
Query: 300 TPAPLKNLRWKPPLVQTS-PPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
TP+P PP + T+ PPP TT SP +T T+ PPP P P
Sbjct: 1577 TPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTT-------------PPPTTTPSPP 1621
Score = 33.5 bits (75), Expect = 0.52
Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 7/59 (11%)
Query: 294 TGSFNFTPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAV 352
T S TP+P PP T+P P TT SP +T T+L ++ P PP++
Sbjct: 1714 TPSSTTTPSP-------PPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPLPPSI 1765
Score = 32.3 bits (72), Expect = 1.2
Identities = 16/51 (31%), Positives = 22/51 (43%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPP 350
TP+P P T+PPP TT SP +T + + + P PP
Sbjct: 1476 TPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPP 1526
Score = 32.3 bits (72), Expect = 1.2
Identities = 19/57 (33%), Positives = 23/57 (40%), Gaps = 13/57 (22%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
TP+P PP T+ PP TT SP +T T+ PPP P P
Sbjct: 1499 TPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTT-------------PPPTTTPSPP 1542
Score = 30.8 bits (68), Expect = 3.4
Identities = 18/57 (31%), Positives = 23/57 (40%), Gaps = 6/57 (10%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSP 356
TP+P + PP T PP TT SP +T + + PPP P P
Sbjct: 1453 TPSPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTT------PPPTTTPSPP 1503
Score = 30.0 bits (66), Expect = 5.8
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 8/58 (13%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIP-PPPAVPYSP 356
TP+P P T+PPP TT SP +T + + + P PPP +P
Sbjct: 1522 TPSP-------PTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTP 1572
Score = 30.0 bits (66), Expect = 5.8
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 8/58 (13%)
Query: 300 TPAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIP-PPPAVPYSP 356
TP+P P T+PPP TT SP +T + + + P PPP +P
Sbjct: 1601 TPSP-------PTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTP 1651
Score = 30.0 bits (66), Expect = 5.8
Identities = 32/129 (24%), Positives = 47/129 (36%), Gaps = 29/129 (22%)
Query: 316 TSPPPATTQSPESTMDTSLKKEKSAILDLYIPP--------PPAVPYSPRDENGSFVYGG 367
TS PP + +P+++ TS +S L +PP PP+ P +P +G
Sbjct: 4211 TSNPPPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAPPSTPTAPTTTSGGHTLS- 4269
Query: 368 SSKCKQPLPGPKGSESPNSFLDQESRRRRFTIADSDQLPGYSVETNILPTKMREKTPSYG 427
P P + SP R T S P + + T TP+
Sbjct: 4270 --------PPPSTTTSP------PGTPTRGTTTGSSSAP---TPSTVQTTTTSAWTPT-- 4310
Query: 428 KPRPLSMPA 436
P PLS P+
Sbjct: 4311 -PTPLSTPS 4318
Score = 29.3 bits (64), Expect = 9.9
Identities = 19/65 (29%), Positives = 25/65 (38%), Gaps = 1/65 (1%)
Query: 293 PTGSFNFTPAPLKNLRWKPPLVQTS-PPPATTQSPESTMDTSLKKEKSAILDLYIPPPPA 351
P+ T P PP+ T+ PPP TT SP + T+ + P PP
Sbjct: 1422 PSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTTPSPPTTTPSPPT 1481
Query: 352 VPYSP 356
SP
Sbjct: 1482 TTPSP 1486
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 36.6 bits (83), Expect = 0.062
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 10/88 (11%)
Query: 217 IKPGEGLGMYIKS-----TYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVG--- 268
+K GLG+ + T DG VI + A+++ I AGDE++ +N + +VG
Sbjct: 2754 LKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPLVGLMH 2813
Query: 269 WQLKNLVKKLRENPTGVVLLLKKRPTGS 296
+ N++K + E P V LL++K S
Sbjct: 2814 FDAWNIMKSVPEGP--VQLLIRKHRNSS 2839
Score = 35.8 bits (81), Expect = 0.11
Identities = 29/100 (29%), Positives = 45/100 (45%), Gaps = 10/100 (10%)
Query: 199 TDPVMSQCACLEEV----HLPNIKPGEGLGMYIKSTYDGLH-----VITGTTENSPADRS 249
TD S C EEV + +K +GLG+ + V+T E A R
Sbjct: 316 TDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRD 375
Query: 250 QKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLL 289
++ GDE++ +N +VG + V LR + TG+V L+
Sbjct: 376 GRLSLGDELLVINGHLLVGLSHEEAVAILR-SATGMVQLV 414
Score = 31.6 bits (70), Expect = 2.0
Identities = 13/32 (40%), Positives = 21/32 (65%)
Query: 237 ITGTTENSPADRSQKIHAGDEVIQVNQQTVVG 268
+T +NSPA +S K+ DE++ +N Q +VG
Sbjct: 121 VTELRKNSPAGKSGKVRLRDEILSLNGQLMVG 152
>gi|7706091 bifunctional apoptosis regulator [Homo sapiens]
Length = 450
Score = 35.4 bits (80), Expect = 0.14
Identities = 19/71 (26%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 4 VTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVT--RIGHQEL 61
V KW+ ++VV W L Y +F E++NG LL ++ ++ + T H+
Sbjct: 179 VAKWTAEEVVLWLEQLGPWASLYRERFLSERVNGRLLLTLTEEEFSKTPYTIENSSHRRA 238
Query: 62 VLEAVDLLCAL 72
+L ++ + AL
Sbjct: 239 ILMELERVKAL 249
>gi|110346438 FERM and PDZ domain containing 2 isoform 1 [Homo
sapiens]
Length = 1287
Score = 35.4 bits (80), Expect = 0.14
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 13/99 (13%)
Query: 245 PADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPL 304
PA+ + I AGD ++ VN ++ G + ++ LR P V LLL + P G+
Sbjct: 1097 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGAL------- 1149
Query: 305 KNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILD 343
P L Q P + E T T S ILD
Sbjct: 1150 ------PELEQEWQTPELSADKEFTRATCTDSCTSPILD 1182
>gi|110346440 FERM and PDZ domain containing 2 isoform 4 [Homo
sapiens]
Length = 320
Score = 35.4 bits (80), Expect = 0.14
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 13/99 (13%)
Query: 245 PADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPL 304
PA+ + I AGD ++ VN ++ G + ++ LR P V LLL + P G+
Sbjct: 130 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGAL------- 182
Query: 305 KNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILD 343
P L Q P + E T T S ILD
Sbjct: 183 ------PELEQEWQTPELSADKEFTRATCTDSCTSPILD 215
>gi|63252916 FERM and PDZ domain containing 2 isoform 2 [Homo
sapiens]
Length = 261
Score = 35.4 bits (80), Expect = 0.14
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 13/99 (13%)
Query: 245 PADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPL 304
PA+ + I AGD ++ VN ++ G + ++ LR P V LLL + P G+
Sbjct: 71 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGAL------- 123
Query: 305 KNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILD 343
P L Q P + E T T S ILD
Sbjct: 124 ------PELEQEWQTPELSADKEFTRATCTDSCTSPILD 156
>gi|110346436 FERM and PDZ domain containing 2 isoform 3 [Homo
sapiens]
Length = 1309
Score = 35.4 bits (80), Expect = 0.14
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 13/99 (13%)
Query: 245 PADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFTPAPL 304
PA+ + I AGD ++ VN ++ G + ++ LR P V LLL + P G+
Sbjct: 1119 PAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGAL------- 1171
Query: 305 KNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILD 343
P L Q P + E T T S ILD
Sbjct: 1172 ------PELEQEWQTPELSADKEFTRATCTDSCTSPILD 1204
>gi|223890252 glutamate receptor interacting protein 1 [Homo
sapiens]
Length = 1076
Score = 35.0 bits (79), Expect = 0.18
Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 2/75 (2%)
Query: 220 GEGLGMYIKSTYDGLH--VITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKK 277
G LG+ I T + +I+ T+ A+R+ IH GD ++ +N ++ G L +
Sbjct: 628 GGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHL 687
Query: 278 LRENPTGVVLLLKKR 292
L+ V L +KK+
Sbjct: 688 LQMAGETVTLKIKKQ 702
>gi|29789379 sphingomyelin synthase 1 [Homo sapiens]
Length = 413
Score = 35.0 bits (79), Expect = 0.18
Identities = 16/56 (28%), Positives = 31/56 (55%), Gaps = 4/56 (7%)
Query: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRI 56
M+ V WSPK+V DW L++ + +Y E G+ L+ ++ +D ++ + R+
Sbjct: 1 MKEVVYWSPKKVADWL--LENAMPEYCEPLEH--FTGQDLINLTQEDFKKPPLCRV 52
>gi|41393579 PDZ domain protein GIPC2 [Homo sapiens]
Length = 315
Score = 35.0 bits (79), Expect = 0.18
Identities = 18/63 (28%), Positives = 30/63 (47%)
Query: 218 KPGEGLGMYIKSTYDGLHVITGTTENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKK 277
K + LG+ I G I + D + I GD + +N + +VGW+ ++ KK
Sbjct: 122 KSEDSLGLTITDNGVGYAFIKRIKDGGVIDSVKTICVGDHIESINGENIVGWRHYDVAKK 181
Query: 278 LRE 280
L+E
Sbjct: 182 LKE 184
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,271,922
Number of Sequences: 37866
Number of extensions: 1290287
Number of successful extensions: 4279
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 3945
Number of HSP's gapped (non-prelim): 426
length of query: 555
length of database: 18,247,518
effective HSP length: 107
effective length of query: 448
effective length of database: 14,195,856
effective search space: 6359743488
effective search space used: 6359743488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.