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Search of human proteins with 74272284
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74272284 membrane associated guanylate kinase, WW and PDZ
domain containing 1 isoform c [Homo sapiens]
(1462 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 2961 0.0
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 2434 0.0
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 2429 0.0
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 973 0.0
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 945 0.0
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 934 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 131 4e-30
gi|112382257 InaD-like [Homo sapiens] 119 3e-26
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 99 4e-20
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 96 2e-19
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens] 96 3e-19
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 96 3e-19
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 96 3e-19
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 91 1e-17
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 89 2e-17
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 89 2e-17
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 89 2e-17
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 89 4e-17
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 89 4e-17
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 89 4e-17
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 87 9e-17
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 86 3e-16
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 85 4e-16
gi|45827729 scribble isoform b [Homo sapiens] 85 6e-16
gi|45827731 scribble isoform a [Homo sapiens] 85 6e-16
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 83 2e-15
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 83 2e-15
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 82 4e-15
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 81 6e-15
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 80 2e-14
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 2961 bits (7677), Expect = 0.0
Identities = 1462/1462 (100%), Positives = 1462/1462 (100%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
Query: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
Sbjct: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
Query: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
Sbjct: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
Query: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
Sbjct: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
Query: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
Sbjct: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIG 840
TDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIG
Sbjct: 781 TDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIG 840
Query: 841 HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFA 900
HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFA
Sbjct: 841 HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFA 900
Query: 901 VPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSG 960
VPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSG
Sbjct: 901 VPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSG 960
Query: 961 VVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADR 1020
VVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADR
Sbjct: 961 VVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADR 1020
Query: 1021 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIA 1080
CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIA
Sbjct: 1021 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIA 1080
Query: 1081 TITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG 1140
TITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG
Sbjct: 1081 TITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG 1140
Query: 1141 REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1200
REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF
Sbjct: 1141 REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1200
Query: 1201 LKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKR 1260
LKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKR
Sbjct: 1201 LKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKR 1260
Query: 1261 AHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKR 1320
AHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKR
Sbjct: 1261 AHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKR 1320
Query: 1321 RSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQ 1380
RSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQ
Sbjct: 1321 RSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQ 1380
Query: 1381 RRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGR 1440
RRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGR
Sbjct: 1381 RRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGR 1440
Query: 1441 SSRHPPEQRRRPYKECSTDLSI 1462
SSRHPPEQRRRPYKECSTDLSI
Sbjct: 1441 SSRHPPEQRRRPYKECSTDLSI 1462
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 2434 bits (6308), Expect = 0.0
Identities = 1217/1283 (94%), Positives = 1226/1283 (95%), Gaps = 31/1283 (2%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
Query: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
Sbjct: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
Query: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
Sbjct: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
Query: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
Sbjct: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
Query: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
Sbjct: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENR----------------------------LPDYQEQ 812
TDSSGQKKPDPFKIWAQSRSMYENR +PDYQEQ
Sbjct: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
Query: 813 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 872
DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
Sbjct: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
Query: 873 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 932
HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
Sbjct: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
Query: 933 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 992
GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
Sbjct: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
Query: 993 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1052
EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE
Sbjct: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
Query: 1053 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1112
AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA
Sbjct: 1081 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
Query: 1113 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1172
PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE
Sbjct: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
Query: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEV-- 1230
INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY + + E
Sbjct: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF 1260
Query: 1231 -RAGPDRRQHPSLESSYPPDLHK 1252
G ++ P+ ++ PP +HK
Sbjct: 1261 YLMGHNQTTTPAATATAPPPVHK 1283
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 2429 bits (6295), Expect = 0.0
Identities = 1212/1250 (96%), Positives = 1216/1250 (97%), Gaps = 29/1250 (2%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
Query: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
Sbjct: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
Query: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
Sbjct: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
Query: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
Sbjct: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
Query: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
Sbjct: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENR----------------------------LPDYQEQ 812
TDSSGQKKPDPFKIWAQSRSMYENR +PDYQEQ
Sbjct: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
Query: 813 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 872
DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
Sbjct: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
Query: 873 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 932
HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
Sbjct: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
Query: 933 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 992
GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
Sbjct: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
Query: 993 EAGTTF-GNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1051
EAGTTF GNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK
Sbjct: 1021 EAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1080
Query: 1052 EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK 1111
EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK
Sbjct: 1081 EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK 1140
Query: 1112 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1171
APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL
Sbjct: 1141 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1200
Query: 1172 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPA 1221
EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY S+ + P+
Sbjct: 1201 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYGGSNYENIPS 1250
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 973 bits (2516), Expect = 0.0
Identities = 557/1124 (49%), Positives = 726/1124 (64%), Gaps = 121/1124 (10%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSK ++KK+HWTS+VHE + R P+G+LG + GGAE+G+FPY+G V + A
Sbjct: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAY----ES 56
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
G +L ELLLEV V+GL DVL VI CK+ + K V+QGG ++KDLRH+LN RF
Sbjct: 57 GSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRF 116
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGS DHELQQ IRDNLY VPCTTR +EGEVPGVDY F+TV++F++LE+SG LLE G
Sbjct: 117 QKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESG 176
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYE NYYGTPKPP++P + TD + + S + KR KS ++M+ A I E EE
Sbjct: 177 TYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPE-EE 235
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQET-ALPPVNSSIIAAPITDPSQKFPQYL----PLSA 295
E++ P +N + + E EH + A + S AP+ ++ + + P
Sbjct: 236 EEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKP 295
Query: 296 EDN--LGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
EDN PLP+NWEMAYTE GEVYFIDHNTKTTSWLDPR L K+ KP EEC+++
Sbjct: 296 EDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR-LAKKAKPPEECKEN------ 348
Query: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
ELP GWEKI+DP+YG YYVDHINR+TQ+ENPVLEAKRK
Sbjct: 349 ------ELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRK---------------- 386
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
QQ TE T +P + + KP FTR+ S+LKG F+ T
Sbjct: 387 LQQHNMPHTELGT-------------------KPLQAPGFREKPLFTRDASQLKGTFLST 427
Query: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
L+KS+ GFGFT++GGDEPDEFLQ+KS++ DGPAA DGKMETGDVIV +N+ CVLGHTHA
Sbjct: 428 TLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 487
Query: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK-EPIIVNGQETYDSP 592
VVK+FQS+PIG SV+L LCRGYPLPFDP+DP S+V +AI+++ P++VNG+ Y++
Sbjct: 488 DVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETY 547
Query: 593 ASHSSKTGK-VNGMKDARP----SSPADVASNSSHGYP--NDTVSLASSIATQPELITVH 645
+ S+T + V + D P S P D + ++ P +D VS+ASS ATQ EL+T+
Sbjct: 548 LEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLT 607
Query: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705
IVKG GFGFTIADSP GQRVKQI+D C GL EGDLIVE+N++NVQ L+H +VVD+
Sbjct: 608 IVKGAQGFGFTIADSP--TGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDI 665
Query: 706 LVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ 765
L +CP GSE +L++ RGG P K+PK ++R ++Q S Q S+S+ A P Q
Sbjct: 666 LKDCPIGSETSLIIHRGGFFSPWKTPK-PIMDRWENQGSPQTSLSA-----PAIP----Q 715
Query: 766 VLPEFPPA--EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRL--------------PDY 809
LP FPPA + PD T++ +KPDP++++ +SR++YE+R PDY
Sbjct: 716 NLP-FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDY 774
Query: 810 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
+E D+ L R E+GFGFRILGG+EPG+PI IG ++ +G+AD DGRL GDEL+ VDG PV
Sbjct: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
Query: 870 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVF-AVPKTEN-EVPSPASSHHSSNQPASLTEE 927
GK+H+ V+ LM AA+ G VNLTVRRKV+ P EN P S+HHSS
Sbjct: 835 GKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSS--------- 885
Query: 928 KRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVS 987
R+ + + N + S ++ G S +Q DV I R ENEGFGFVI+S
Sbjct: 886 PRSDYATYTNSNHAAPSSNASP--------PEGFASHSLQTSDVVIHRKENEGFGFVIIS 937
Query: 988 SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1047
S++RPE+G+T + +PHKIGRII+GSPADRC KLKVGDRILAVNG SI N H+DIV
Sbjct: 938 SLNRPESGST-----ITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIV 992
Query: 1048 NLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1091
LIK+AG +VTLRIIP +E ++ T ++EK + + +QQ
Sbjct: 993 KLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQ 1036
Score = 174 bits (442), Expect = 4e-43
Identities = 121/306 (39%), Positives = 153/306 (50%), Gaps = 25/306 (8%)
Query: 1107 QFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRI 1166
Q+ + Q+ D++TV++E+GAKGFGFS+RGGREY MDLYVLRLAEDGPA R G+MR+
Sbjct: 1131 QYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRV 1190
Query: 1167 GDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQG 1226
GD+I+EINGE+T++M H+RAIELIK+GGRRVRL LKRG G VPEYD + PA G
Sbjct: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPG 1250
Query: 1227 VPEVRA------GPDRRQHPSLESSYPPDLHKSSPHGEKRAH-ARDPKGSREYSRQPNEH 1279
+PEV P HP+ S + KR H R PK ++
Sbjct: 1251 LPEVGVSLDDGLAPFSPSHPAPPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRL 1310
Query: 1280 HTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLER 1339
S P A + AP G+ +A R A+ E R G +AD
Sbjct: 1311 GEQRERSASPQRAARPRLEEAPGGQGRPEAGRPAS---------EARAPGLAAADAADAA 1361
Query: 1340 RE--KHEKRRDVSPER-RRE---RSPTRRRDGSPSRRRRSLERLLEQRRSPE---RRRGG 1390
R K R E RRE +P G E R P R GG
Sbjct: 1362 RAGGKEAPRAAAGSELCRREGPGAAPAFAGPGGGGSGALEAEGRAGARAGPRPGPRPPGG 1421
Query: 1391 SPERRA 1396
+P R+A
Sbjct: 1422 APARKA 1427
Score = 125 bits (314), Expect = 3e-28
Identities = 206/958 (21%), Positives = 355/958 (37%), Gaps = 151/958 (15%)
Query: 390 PVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR 449
P E KRK+ ++ + +++++++ + +V P H + +
Sbjct: 209 PSAEGKRKRNKSVSNMEKASIEPPEEEEEERPV---VNGNGVVVTPESSEHEDKSAGASG 265
Query: 450 EVPLQGKPF-FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAA 508
E+P Q P P ELK + TK K +EPD +
Sbjct: 266 EMPSQPYPAPVYSQPEELKEQMDDTKPTKPE--------DNEEPDPLPDNWEMAYT---- 313
Query: 509 LDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFD---PDDP 565
E G+V ++T ++ K + E C+ LP+ DDP
Sbjct: 314 -----EKGEVYFIDHNTKTTSWLDPRLAK--------KAKPPEECKENELPYGWEKIDDP 360
Query: 566 NTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP 625
+ +D +N + +++P + + + + M P + + G+
Sbjct: 361 ----IYGTYYVDH----INRRTQFENPVLEAKRKLQQHNM----PHTELGTKPLQAPGFR 408
Query: 626 NDTVSLASSIATQPELITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRG--LK 681
+ + + ++ + K MGFGFTI D P Q I D P + ++
Sbjct: 409 EKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKME 468
Query: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRG-GLPVPKKSPKSQ---PLE 737
GD+IV +N+ V TH VV + P G V L++ RG LP + P + PL
Sbjct: 469 TGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLA 528
Query: 738 RKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD-PFKIWA 796
+ + + + S ++Q +P+ + + GQ P +
Sbjct: 529 IMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHD 588
Query: 797 QSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDG--RL 854
+ SM + + + + + GFGF I + G+ + D G L
Sbjct: 589 DNVSMASSGATQAELMTLTIVKGAQGFGFTI-ADSPTGQRVK-------QILDIQGCPGL 640
Query: 855 RSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKT--------EN 906
GD ++ ++ V SH VV +++ +L + R F+ KT EN
Sbjct: 641 CEGDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWEN 700
Query: 907 E---------------VPSPASSHHSS------------NQPASLTEEKRTPQGSQNSLN 939
+ +P P + H SS P L E+ R S+ +
Sbjct: 701 QGSPQTSLSAPAIPQNLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVP 760
Query: 940 TVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFG 999
+S +SG + DV +RR E+ GFGF I+ E G
Sbjct: 761 PRTSFRMDSSGPD-------------YKELDVHLRRMES-GFGFRILGG---DEPG---- 799
Query: 1000 NACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN---- 1055
P IG +I ADR G+L GD ++ V+G + K+H +++L+ A
Sbjct: 800 -----QPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQV 854
Query: 1056 --TVTLRIIPGDESSNATLLTNAEKIATITTTHTP--SQQGTQETRNTTKPKQE-SQFEF 1110
TV +++ G E N +++T H+ S T N P S E
Sbjct: 855 NLTVRRKVLCGGEPCPE----NGRSPGSVSTHHSSPRSDYATYTNSNHAAPSSNASPPEG 910
Query: 1111 KAPQATQEQDFYTVELERGAKGFGFSL-------RGGREYNMDLYVLRLAEDGPAERCGK 1163
A + Q D E +GFGF + G + + R+ + PA+RC K
Sbjct: 911 FASHSLQTSDVVIHRKEN--EGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAK 968
Query: 1164 MRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL-FLKRGDGSVPEYDPSSDRHGPAT 1222
+++GD IL +NG++ NM H+ ++LIK+ G V L + + + + P PSS++ P
Sbjct: 969 LKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMA 1028
Query: 1223 G----PQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQP 1276
Q P + P P + + P L R+ + + + RQP
Sbjct: 1029 QQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQP 1086
Score = 113 bits (282), Expect = 2e-24
Identities = 130/520 (25%), Positives = 206/520 (39%), Gaps = 121/520 (23%)
Query: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
K + LR+ GFGF ++GGDEP + + I +++ G A DG++ GD +V V+ V
Sbjct: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
Query: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQET 588
G TH V+ + V+L + R + EP NG+
Sbjct: 835 GKTHRYVIDLMHHAARNGQVNLTVRRK------------------VLCGGEPCPENGRSP 876
Query: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT---QPELITVH 645
HSS P S +NS+H P+ S A+ Q + +H
Sbjct: 877 GSVSTHHSS------------PRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIH 924
Query: 646 IVKGPMGFGFTIADS---PGGGG-----QRVKQIVD---SPRCRGLKEGDLIVEVNKKNV 694
K GFGF I S P G ++ +I+D + RC LK GD I+ VN +++
Sbjct: 925 R-KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI 983
Query: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKK---SPKSQPLERKDSQNSSQHSVSS 751
+ H +V ++ + G VTL + +P++ SP S P K S + Q ++
Sbjct: 984 INMPHADIVKLIKDA--GLSVTLRI------IPQEELNSPTSAPSSEKQSPMAQQSPLAQ 1035
Query: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK-------------KPD----PFKI 794
L A PS +T P P A+ P G + KPD PF
Sbjct: 1036 QSPL--AQPSPAT---PNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTD 1090
Query: 795 WAQSRSMYENR--------------------------------LPDYQEQDIF------L 816
+ Q Y L DY++ F +
Sbjct: 1091 YRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDM 1150
Query: 817 WRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 876
+ GFGF I GG E +Y+ + G A +GR+R GD++I ++G +H
Sbjct: 1151 EKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA 1210
Query: 877 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP--SPASS 914
++L++ ++ V L ++R VP+ + P SPA++
Sbjct: 1211 IELIKSGGRR--VRLLLKRG-TGQVPEYDEPAPWSSPAAA 1247
Score = 66.6 bits (161), Expect = 2e-10
Identities = 108/456 (23%), Positives = 169/456 (37%), Gaps = 90/456 (19%)
Query: 476 RKSSRGFGFTVVGG-DEPDEFLQIK-----SLVLDG-PAALDGKMETGDVIVSVNDTCVL 528
RK + GFGF ++ + P+ I ++DG PA K++ GD I++VN ++
Sbjct: 925 RKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSII 984
Query: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVA----ILDKEPIIVN 584
HA +VK+ + G SV L + L P++ + +A + + P+
Sbjct: 985 NMPHADIVKLIKDA--GLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLAQP 1042
Query: 585 GQETYDSPASH-------------SSKTGKVNGMKDARPS-----------SPADVASNS 620
T +SP + +S +V +D +P P D
Sbjct: 1043 SPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPP 1102
Query: 621 SHGYPN-------------------DTVSLASSIATQPE---LITVHIVKGPMGFGFTIA 658
Y DT S QP+ TV + KG GFGF+I
Sbjct: 1103 GGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIR 1162
Query: 659 DSPGGGGQRVKQIV-------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
GG+ K + D P R ++ GD I+E+N ++ + +TH + ++++
Sbjct: 1163 -----GGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS- 1216
Query: 710 PKGSEVTLLVQRGGLPVP---KKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQV 766
G V LL++RG VP + +P S P + + VS L SPSH
Sbjct: 1217 -GGRRVRLLLKRGTGQVPEYDEPAPWSSPAAA--APGLPEVGVSLDDGLAPFSPSHPA-- 1271
Query: 767 LPEFPPAEAQAPDQT----DSSGQKKPDPFKIWAQSRS-MYENRLPDYQEQDIFLWRKET 821
P P+ +P T +KP Q + + E R Q R E
Sbjct: 1272 -PPSDPSHQISPGPTWDIKREHDVRKPKELSACGQKKQRLGEQRERSASPQRAARPRLEE 1330
Query: 822 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSG 857
G + G E G P L AAD R+G
Sbjct: 1331 APGGQ--GRPEAGRPASEARAPGLAAADAADAARAG 1364
Score = 58.9 bits (141), Expect = 3e-08
Identities = 120/552 (21%), Positives = 191/552 (34%), Gaps = 103/552 (18%)
Query: 22 RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGL 81
R + G +LGG E G+ +GAV A+ +A G RL G+ L+ V G+ V+G
Sbjct: 782 RRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDG-----RLHPGDELVYVDGIPVAGK 836
Query: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHA 141
V+ ++ A R G ++ T+R +
Sbjct: 837 THRYVIDLMHH--------AARNG----------------------QVNLTVRRKVLCGG 866
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKV 201
PC P G PG + S + TY + + P + P G
Sbjct: 867 EPC----PENGRSPGS----------VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGF- 911
Query: 202 ITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEH 261
A HSLQ+ K + + + + + E+ VP S
Sbjct: 912 ----ASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCA 967
Query: 262 TLQ--ETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFI 319
L+ + L SII P D K + LS + P E +
Sbjct: 968 KLKVGDRILAVNGQSIINMPHAD-IVKLIKDAGLSVTLRIIPQEE--------------L 1012
Query: 320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVD 379
+ T S + + QQ PL + +S + PA + ++ + Y
Sbjct: 1013 NSPTSAPS-SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRS 1071
Query: 380 HINR----KTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
+ K P R+ L+ +Q QQ +Q PP
Sbjct: 1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ-------------PP 1118
Query: 436 VIP--NHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPD 493
++ H P R+ PL R P + + + K ++GFGF++ GG E
Sbjct: 1119 LLDYRQHSPDT----RQYPLSDY----RQPQDFD--YFTVDMEKGAKGFGFSIRGGREYK 1168
Query: 494 EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELC 553
L + L DGPA +G+M GD I+ +N THA+ +++ +S G V L L
Sbjct: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS--GGRRVRLLLK 1226
Query: 554 RGYPLPFDPDDP 565
RG + D+P
Sbjct: 1227 RGTGQVPEYDEP 1238
Score = 45.1 bits (105), Expect = 5e-04
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 13/96 (13%)
Query: 969 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1028
+ V++ +G +GFGF I G M + R+ E PA R G+++VGD
Sbjct: 1146 FTVDMEKGA-KGFGFSIR------------GGREYKMDLYVLRLAEDGPAIRNGRMRVGD 1192
Query: 1029 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1064
+I+ +NG S + +H+ + LIK G V L + G
Sbjct: 1193 QIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRG 1228
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 945 bits (2443), Expect = 0.0
Identities = 582/1508 (38%), Positives = 813/1508 (53%), Gaps = 235/1508 (15%)
Query: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
Query: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
Query: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
Query: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
Query: 235 HAENEEEDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLS 294
E EE++D +N S A++ E+ + P + T+ S F Y+
Sbjct: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ------TNSSMDFRNYM--M 287
Query: 295 AEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEE 354
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED E
Sbjct: 288 RDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDGE------ 340
Query: 355 LDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQ 414
LP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 341 ------LPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQV----------- 383
Query: 415 QQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTK 474
E P K FTR+PS+LKG +
Sbjct: 384 -------------------------------EIGSSKPDMEKSHFTRDPSQLKGVLVRAS 412
Query: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 535 VVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPAS 594
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGETC 525
Query: 595 HSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKGP 650
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KGP
Sbjct: 526 MNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGP 585
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L + P
Sbjct: 586 KGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP 643
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
G++V LL+ RGG P P K+ K + + + S +++ P Q +P F
Sbjct: 644 VGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP-F 690
Query: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG 830
PP+ + SG K DP +++ +S+++YE++ P+ ++ D+FL ++E+GFGFR+LGG
Sbjct: 691 PPSIIR-------SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG 743
Query: 831 NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890
+ P + IYIG I+PLGAA+ DGRLR+ DEL+C+DG PV GKSH+ V+ LM AA+ GHV
Sbjct: 744 DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVL 803
Query: 891 LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950
LTVRRK+ + + E++ S + + + E P
Sbjct: 804 LTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQ---------------- 847
Query: 951 IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010
+PYDV ++R ENEGFGFVI++S ++P G +PHKIG
Sbjct: 848 ----------------EPYDVVLQRKENEGFGFVILTSKNKPPPG--------VIPHKIG 883
Query: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNA 1070
R+IEGSPADRCGKLKVGD I AVNG SI SH +IV LIK+AG TVTL +I +E
Sbjct: 884 RVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Query: 1071 TLLTNAEK---------IATITTTHTPSQQGTQE---TRNTTKPKQESQFEFK------- 1111
TN+ + + H P + E ++ + + S + K
Sbjct: 944 PSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDT 1003
Query: 1112 ------APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1165
+ Q Y VELERG +GFGFSLRGG+EYNM L++LRLAEDGPA + G++
Sbjct: 1004 AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIH 1063
Query: 1166 IGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPE--------------- 1210
+GD+I+EINGE T+ + H+RAIELI+ GG +V L L+ G G +P+
Sbjct: 1064 VGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVI 1123
Query: 1211 YD-----PSSDRHGPATGPQGVPEVRAG----------------PDRRQHPSLESSYPPD 1249
YD P S VP + P+++ +L + P
Sbjct: 1124 YDEQSPLPPSSHFASIFEESHVPVIEESLRVQICEKAEELKDIVPEKKS--TLNENQPEI 1181
Query: 1250 LHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQA 1309
H+S +K RDP S +S + N NG +R+ S + + K +
Sbjct: 1182 KHQSLL--QKNVSKRDPPSSHGHSNKKNLLKVENGVTRRGRSVSPK-KPASQHSEEHLDK 1238
Query: 1310 ERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRD-VSPERRRERSPTRRRDGSPS 1368
+ N PKRR ++ ++ + + + + +D R R SP +++ S
Sbjct: 1239 IPSPLKNNPKRRPRDQSLSPSKGENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGS 1298
Query: 1369 RRRRSLERLLEQRRSPERRRGG--------SPERRAKS-----------TDRRRARSPER 1409
+ + E L + +S RR G P+ + KS ++ R RSPE+
Sbjct: 1299 KAPSNAEAKLLEGKS--RRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEK 1356
Query: 1410 RRERSLDK 1417
+ +R ++K
Sbjct: 1357 KIKRMVEK 1364
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 934 bits (2413), Expect = 0.0
Identities = 532/1246 (42%), Positives = 723/1246 (58%), Gaps = 172/1246 (13%)
Query: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
Query: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
Query: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
Query: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
Query: 235 HAENEEEDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLS 294
E EE++D +N S A++ E+ + P + T+ S F Y+
Sbjct: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ------TNSSMDFRNYM--M 287
Query: 295 AEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEE 354
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED E
Sbjct: 288 RDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDGE------ 340
Query: 355 LDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQ 414
LP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 341 ------LPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQV----------- 383
Query: 415 QQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTK 474
E P K FTR+PS+LKG +
Sbjct: 384 -------------------------------EIGSSKPDMEKSHFTRDPSQLKGVLVRAS 412
Query: 475 LRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 413 LKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHAD 472
Query: 535 VVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPAS 594
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 473 VVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGETC 525
Query: 595 HSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKGP 650
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KGP
Sbjct: 526 MNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGP 585
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L + P
Sbjct: 586 KGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFP 643
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
G++V LL+ RGG P P K+ K + + + S +++ P Q +P F
Sbjct: 644 VGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP-F 690
Query: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG 830
PP+ + SG K DP +++ +S+++YE++ P+ ++ D+FL ++E+GFGFR+LGG
Sbjct: 691 PPSIIR-------SGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGG 743
Query: 831 NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890
+ P + IYIG I+PLGAA+ DGRLR+ DEL+C+DG PV GKSH+ V+ LM AA+ GHV
Sbjct: 744 DGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVL 803
Query: 891 LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950
LTVRRK+ + + E++ S + + + E P
Sbjct: 804 LTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQ---------------- 847
Query: 951 IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010
+PYDV ++R ENEGFGFVI++S ++P G +PHKIG
Sbjct: 848 ----------------EPYDVVLQRKENEGFGFVILTSKNKPPPG--------VIPHKIG 883
Query: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNA 1070
R+IEGSPADRCGKLKVGD I AVNG SI SH +IV LIK+AG TVTL +I +E
Sbjct: 884 RVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGP 943
Query: 1071 TLLTNAEK---------IATITTTHTPSQQGTQE---TRNTTKPKQESQFEFK------- 1111
TN+ + + H P + E ++ + + S + K
Sbjct: 944 PSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDT 1003
Query: 1112 ------APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMR 1165
+ Q Y VELERG +GFGFSLRGG+EYNM L++LRLAEDGPA + G++
Sbjct: 1004 AVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIH 1063
Query: 1166 IGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1211
+GD+I+EINGE T+ + H+RAIELI+ GG +V L L+ G G +P++
Sbjct: 1064 VGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDH 1109
Score = 92.8 bits (229), Expect = 2e-18
Identities = 166/701 (23%), Positives = 265/701 (37%), Gaps = 116/701 (16%)
Query: 641 LITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRGLK--EGDLIVEVNKKNVQA 696
L+ + K MGFGFTI D P Q + D P + K GD+IV++N V
Sbjct: 408 LVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLG 467
Query: 697 LTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLH 756
TH VV M P V L + RG P+P S E + V + +SL
Sbjct: 468 HTHADVVQMFQLVPVNQYVNLTLCRG-YPLPDDS------EDPVVDIVAATPVINGQSLT 520
Query: 757 TASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD-----PFKIWAQSRSMYENRLPDYQE 811
+ Q +F P A +Q SG P Q SM + +
Sbjct: 521 KGETCMNPQ---DFKPG-AMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPEL 576
Query: 812 QDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK 871
I L + GFGF I + G+ + + L + G L+ GD + + V
Sbjct: 577 VTIPLIKGPKGFGFAI-ADSPTGQKVKM----ILDSQWCQG-LQKGDIIKEIYHQNVQNL 630
Query: 872 SHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKT---ENEVPSPASSHHSSNQPASLTEEK 928
+H VV++++Q V L + R + KT + + A S + N+P
Sbjct: 631 THLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPI------ 684
Query: 929 RTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI-RRGENEGFGFVIVS 987
PQ + + SGS + D+++ R + GFGF ++
Sbjct: 685 --PQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLG 742
Query: 988 SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1047
++ IG II A++ G+L+ D ++ ++G + KSH ++
Sbjct: 743 GDGPDQS------------IYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790
Query: 1048 NLIKEAGN------TVTLRII-----PGDESSNATLLTNAEKIATITTTHTPSQQGTQET 1096
+L+ A TV +I P D+SS A + T Q G+
Sbjct: 791 DLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFIST---------------QNGSPRL 835
Query: 1097 RNTTKPKQESQFEFKAPQATQEQDFYTVELERGA-KGFGFSLRGGREYN----MDLYVLR 1151
P + + Q+ Y V L+R +GFGF + + + + R
Sbjct: 836 NRAEVPARPAP-----------QEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGR 884
Query: 1152 LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1211
+ E PA+RCGK+++GD I +NG++ + H ++LIK+ G V L +
Sbjct: 885 VIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTV---------- 934
Query: 1212 DPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSRE 1271
+ HGP +G + A R S + P D +S+ GE +D S
Sbjct: 935 IAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGD--RSALEGE---IGKDVSTSYR 989
Query: 1272 YSRQPNEHHTWNGT-------SRKPDSGACRP--KDRAPEG 1303
+S ++H T SR + C P +R P G
Sbjct: 990 HSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRG 1030
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 131 bits (330), Expect = 4e-30
Identities = 196/845 (23%), Positives = 334/845 (39%), Gaps = 116/845 (13%)
Query: 414 QQQQQQQQTEEWTEDH-------SALVPPVIPNHPPSNPEPARE---VPLQGKPFFTRNP 463
+QQ + + T WTE H SA +P V+P+ E E + + +N
Sbjct: 941 EQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNV 1000
Query: 464 SELKGKFIHT-KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
S K F T + K + G TV + + ++S++ G + DG++ GD I+S+
Sbjct: 1001 S--KESFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSI 1057
Query: 523 NDTCVLGHTHAQVVKIFQSIP-IGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPI 581
N+ + T+AQ + + IG + + P L L ++
Sbjct: 1058 NEESTISVTNAQARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSG 1106
Query: 582 IVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPEL 641
V + + SS TG+ R + + + Y N + +P
Sbjct: 1107 RVMALDIF------SSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSK 1160
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALT 698
+ G G G +++ G +K ++ DSP + LK GD IVEV+ +++ +
Sbjct: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
Query: 699 HNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLER---KDSQNSSQHSVSSHRSL 755
H Q V+ + + G+ V +VQ + P+KSP L K + +S+ S +
Sbjct: 1221 HEQAVEAIRKA--GNPVVFMVQ-SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQIN 1277
Query: 756 HTASPSHSTQ---------VLPEFPPAEAQ-APDQTDSSGQK------KPDPFKI-WAQS 798
+PS S V P P A A+ D T SS K K D F W
Sbjct: 1278 ADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNI 1337
Query: 799 RSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGE-PIYIGHIVPLGAADTDGRLRSG 857
R Y + I L + +G G + G + ++I I P GAA DGRL+
Sbjct: 1338 RERYGTLTGELHM--IELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIA 1395
Query: 858 DELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV--FAVPKTENEVPSPASSH 915
DEL+ ++G + G+SHQ +++ A + + + V AV P P++S
Sbjct: 1396 DELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSE 1455
Query: 916 HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRR 975
+ N+ TE T + L++ + GG G I
Sbjct: 1456 NLQNKE---TEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLG---------------IAI 1497
Query: 976 GENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNG 1035
E + VI+ S++ E A G+LKVGD+ILAV+
Sbjct: 1498 SEEDTLSGVIIKSLT-----------------------EHGVAATDGRLKVGDQILAVDD 1534
Query: 1036 CSITNKSHSDIVNLIKEAGNTVTLRI---------IPGDESSNATLLTNAEKIATITTTH 1086
+ ++L+K A TV L I +P + + N+ + + +
Sbjct: 1535 EIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSG 1594
Query: 1087 TPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMD 1146
+P + + T ++ P + P + T+E+ +G G G S+ GG + +
Sbjct: 1595 SPEPESIRNTSRSSTPAIFASDPATCPIIPGCET--TIEISKGRTGLGLSIVGGSDTLLG 1652
Query: 1147 LYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGD 1205
++ + E+G A + G++ GD+ILE+NG + H AI +++ +RVRL L R +
Sbjct: 1653 AIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDE 1712
Query: 1206 GSVPE 1210
E
Sbjct: 1713 APYKE 1717
Score = 108 bits (271), Expect = 3e-23
Identities = 174/815 (21%), Positives = 320/815 (39%), Gaps = 156/815 (19%)
Query: 472 HTKLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
H +L K S+G GF+++ +P + + I+SLV G A DG++ GD ++ VND +
Sbjct: 700 HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNL 759
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
+ + V+ + P G + + PLP P++ S + P
Sbjct: 760 ENSSLEEAVEALKGAPSGT---VRIGVAKPLPLSPEEGYVSAKEDSFLY--PPHSCEEAG 814
Query: 588 TYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP----NDTVSLASSIATQPELIT 643
D P + + G D AD+ S+ P ND++ +TQ +++
Sbjct: 815 LADKPLFRADLA--LVGTND------ADLVDESTFESPYSPENDSI-----YSTQASILS 861
Query: 644 VH--IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H + +G ++ SP K ++++ D +++++ + T N
Sbjct: 862 LHGSSCGDGLNYGSSLPSSP------PKDVIEN-------SCDPVLDLHMSLEELYTQNL 908
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
+ P S + G + +P + ++ + +N+ + SH S +
Sbjct: 909 LQRQDENTP--SVDISMGPASGFTINDYTPANAIEQQYECENTIVWT-ESHLPSEVISSA 965
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRS------MYENRLPDYQEQDIF 815
VLP DS+G K + + S + M +N + E+ I
Sbjct: 966 ELPSVLP-------------DSAG--KGSEYLLEQSSLACNAECVMLQNVSKESFERTIN 1010
Query: 816 LWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 875
+ + + G + N+ G + + I+ GA DGR+ GD ++ ++ I
Sbjct: 1011 IAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS----- 1064
Query: 876 VVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQ 935
V +A + H + K+ + PA EE + G Q
Sbjct: 1065 VTNAQARAMLRRHSLIGPDIKITYV--------------------PAEHLEEFKISLGQQ 1104
Query: 936 N----SLNTVSSGSG--------STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGF 983
+ +L+ SS +G G G + S QP VE+ R ++ G
Sbjct: 1105 SGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSKSLG- 1163
Query: 984 VIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSH 1043
+S V G+ N V I ++E SPA + G LK GDRI+ V+G + + SH
Sbjct: 1164 --ISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASH 1221
Query: 1044 SDIVNLIKEAGNTVTLRI-----------IP----------GDESSNA---TLLTNAEKI 1079
V I++AGN V + +P S+N +L NA+K
Sbjct: 1222 EQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281
Query: 1080 ----------ATITTTHTP-----SQQGTQETRNTTKP-----KQESQFEF-----KAPQ 1114
A + + P ++ G+ T+++ +E +F + +
Sbjct: 1282 PSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERY 1341
Query: 1115 ATQEQDFYTVELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKMRIGDEILEI 1173
T + + +ELE+G G G SL G ++ + M ++++ + +G A + G+++I DE+LEI
Sbjct: 1342 GTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEI 1401
Query: 1174 NGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV 1208
NG+ H A +IK +V++ R +V
Sbjct: 1402 NGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAV 1436
Score = 108 bits (269), Expect = 5e-23
Identities = 152/657 (23%), Positives = 276/657 (42%), Gaps = 119/657 (18%)
Query: 581 IIVNGQETYDSPASHSSKTGKVNGMKD------ARPSSPADVASNSSHGYPN--DTVSLA 632
+ +NGQ D +H + KD AR S P V+ S P+ T+S
Sbjct: 189 LAINGQ-ALDQTITHQQAISILQKAKDTVQLVIARGSLPQLVSPIVSRS-PSAASTISAH 246
Query: 633 SSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKE-------GDL 685
S+ + T+ +V G GF I GG+ IV + G+ + GD
Sbjct: 247 SNPVHWQHMETIELVNDGSGLGFGII-----GGKATGVIVKTILPGGVADQHGRLCSGDH 301
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSS 745
I+++ ++ ++ QV +L +C G+ V L++ RG + E + + +
Sbjct: 302 ILKIGDTDLAGMSSEQVAQVLRQC--GNRVKLMIARGAI------------EERTAPTAL 347
Query: 746 QHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENR 805
++SS SP+ + ++ + D+S QK +
Sbjct: 348 GITLSS-------SPTSTPEL-------------RVDASTQKGEES-------------- 373
Query: 806 LPDYQEQDIFLWRKETGFGFRILG--GNEPGEP--IYIGHIVPLGAADTDGRLRSGDELI 861
+ D+ L + G G I G G++ EP I++ I A + DGR++ GD++I
Sbjct: 374 ----ETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQII 429
Query: 862 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN-Q 920
VDGT + G ++Q V++++ + V LT+ R+ + K E E+ S ++
Sbjct: 430 AVDGTNLQGFTNQQAVEVLRHTGQT--VLLTLMRRGM----KQEAELMSREDVTKDADLS 483
Query: 921 PASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRG---- 976
P + + K + ++ L S + +T+ + + G + + + + D + +
Sbjct: 484 PVNASIIKENYEKDEDFL----SSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLT 539
Query: 977 ---ENEGFGF-VIVSSVSRPEAGTTFGNACVAMP--HKIGRIIEGSPADRCGKLKVGDRI 1030
G + ++V+ VS+ + G + A H I ++ P GKL GD +
Sbjct: 540 KWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDEL 599
Query: 1031 LAVNGCSITNKSHSDIVNLIKEAGNTVTL----RIIPGDESSNATLLTNAEKIATITTTH 1086
L VNG ++ ++H D+VN++KE VT+ R +P S L + I T
Sbjct: 600 LEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL----DLCDIELTE 655
Query: 1087 TPSQQ-----GTQETRN---TTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLR 1138
P G+ ET + +S E +AP A E +ELE+G+KG GFS+
Sbjct: 656 KPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKGSKGLGFSIL 715
Query: 1139 GGRE----YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1191
++ + + + L G AE+ G++ GD ++ +N +N A+E +K
Sbjct: 716 DYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Score = 100 bits (250), Expect = 8e-21
Identities = 95/413 (23%), Positives = 168/413 (40%), Gaps = 91/413 (22%)
Query: 800 SMYENRLPDYQEQDIF------LWRKE-TGFGFRILGG-NEPGEPIYIGHIVPLGAADTD 851
++Y + P Y+E+++ L +K G G I+G N+ G +++ IV G AD D
Sbjct: 1707 TLYRDEAP-YKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTG--VFVSDIVKGGIADAD 1763
Query: 852 GRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSP 911
GRL GD+++ V+G V + + V L+
Sbjct: 1764 GRLMQGDQILMVNGEDVRNATQEAVAALL------------------------------- 1792
Query: 912 ASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDV 971
+ +GS +S SGS ++ + S + + S + V
Sbjct: 1793 -----------------KVSEGSLSSFTFPLSGSSTSESLESSSKKNA-LASEIQGLRTV 1834
Query: 972 EIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRIL 1031
E+++G + G I V P +AM H G A + KL+VGDRI+
Sbjct: 1835 EMKKGPTDSLGISIAGGVGSPLGDVPI---FIAMMHPTG------VAAQTQKLRVGDRIV 1885
Query: 1032 AVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1091
+ G S +H+ VNL+K A ++ ++++ G + S + T H
Sbjct: 1886 TICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVS-------------VVTGHQQEPA 1932
Query: 1092 GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG---REYNMDLY 1148
+ + Q + PQ ++ LERG G GFS+ GG ++ +Y
Sbjct: 1933 SSSLSFTGLTSSSIFQDDLGPPQCK------SITLERGPDGLGFSIVGGYGSPHGDLPIY 1986
Query: 1149 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1201
V + G A G+++ GD+I+ +NG++ + + H A+ ++K V L +
Sbjct: 1987 VKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 94.0 bits (232), Expect = 1e-18
Identities = 143/652 (21%), Positives = 249/652 (38%), Gaps = 155/652 (23%)
Query: 472 HTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531
H +L K G G + D + IKSL G AA DG+++ GD I++V+D V+G+
Sbjct: 1483 HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYP 1541
Query: 532 HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591
+ + + ++ + + + +PD A +K+ N ++
Sbjct: 1542 IEKFISLLKTAKMTVKLTIHA-------ENPDSQAVPSAAGAASGEKK----NSSQSLMV 1590
Query: 592 PASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPM 651
P S S + + +R S+PA AS+ + T + T T+ I KG
Sbjct: 1591 PQSGSPEPESIRNT--SRSSTPAIFASDPA------TCPIIPGCET-----TIEISKGRT 1637
Query: 652 GFGFTIADSPGGGGQRVKQIV------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVV 703
G G +I GG + I+ + C+ L GD I+EVN +++ TH++ +
Sbjct: 1638 GLGLSIV---GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
Query: 704 DMLVECPKGSEVTLLVQRGGLP-------------VPKKSPKSQPLE------------- 737
++L + P+ V L + R P + KK K L
Sbjct: 1695 NVLRQTPQ--RVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVS 1752
Query: 738 ------------------------RKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPA 773
+D +N++Q +V++ + S S T FP +
Sbjct: 1753 DIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSSFT-----FPLS 1807
Query: 774 EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG--N 831
+ + +SS +K +I R++ + P G I GG +
Sbjct: 1808 GSSTSESLESSSKKNALASEIQGL-RTVEMKKGPT------------DSLGISIAGGVGS 1854
Query: 832 EPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890
G+ PI+I + P G A +LR GD ++ + GT G +H V L++ A+
Sbjct: 1855 PLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG----- 1909
Query: 891 LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950
++ +VV + + +T ++ P S S ++S S
Sbjct: 1910 -SIEMQVV------------------AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDD 1950
Query: 951 IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010
+G Q + + RG +G GF IV P +P +
Sbjct: 1951 LGPP------------QCKSITLERGP-DGLGFSIVGGYGSPHGD---------LPIYVK 1988
Query: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1062
+ A G+LK GD+I+AVNG S+ +H + V ++K TVTL ++
Sbjct: 1989 TVFAKGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 86.3 bits (212), Expect = 2e-16
Identities = 173/842 (20%), Positives = 313/842 (37%), Gaps = 183/842 (21%)
Query: 476 RKSSRGFGFTVVGG---------DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
R+ S+ G ++VGG E + IK ++ D PA +G ++ GD IV V+
Sbjct: 1156 REPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMD 1215
Query: 527 VLGHTHAQVVKIFQSI--PIGASVD--LELCRGYPLPFDPDDPNTSLVTSVAILDKEPII 582
+ +H Q V+ + P+ V + R PLP +L P
Sbjct: 1216 LRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLP----SLLHNLYPKYNFSSTNPFA 1271
Query: 583 VNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPE-- 640
+ Q D S S + + P P+ A S + ++ + + E
Sbjct: 1272 DSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFG 1331
Query: 641 ----------------LITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEG- 683
L + + KG G G ++A + V + P K+G
Sbjct: 1332 YSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGR 1391
Query: 684 ----DLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK 739
D ++E+N + + +H Q +++C S+V ++ R K
Sbjct: 1392 LQIADELLEINGQILYGRSH-QNASSIIKCAP-SKVKIIFIRN----------------K 1433
Query: 740 DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR 799
D+ N P ++ + LP +++ K+ +P + +
Sbjct: 1434 DAVNQM-----------AVCPGNAVEPLPS----------NSENLQNKETEPTVTTSDAA 1472
Query: 800 ---SMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRS 856
S ++N Q + L + + G G I + + I + G A TDGRL+
Sbjct: 1473 VDLSSFKN------VQHLELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKV 1525
Query: 857 GDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHH 916
GD+++ VD V+G + + L++ A +TV+ + P ++ VPS A +
Sbjct: 1526 GDQILAVDDEIVVGYPIEKFISLLKTA------KMTVKLTIHAENPDSQ-AVPSAAGA-- 1576
Query: 917 SSNQPASLTEEKRTPQ-GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRR 975
+S + + ++ PQ GS + ++ ST I + ++ +EI +
Sbjct: 1577 ASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETT--IEISK 1634
Query: 976 GENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNG 1035
G G G IV T A + I + E A + G+L GD+IL VNG
Sbjct: 1635 GRT-GLGLSIVGG------SDTLLGAII-----IHEVYEEGAACKDGRLWAGDQILEVNG 1682
Query: 1036 CSITNKSHSDIVNLIK--------------------EAGNTVTLRI-----------IPG 1064
+ +H + +N+++ E +T+T+ + I G
Sbjct: 1683 IDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVG 1742
Query: 1065 DESSNATLLTNAEKIATITTTHTPSQQGTQ-------ETRNTTKPKQE----------SQ 1107
+ +++ K I QG Q + RN T+ S
Sbjct: 1743 KRNDTGVFVSDIVK-GGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKVSEGSLSS 1801
Query: 1108 FEF----------------KAPQATQEQDFYTVELERG-AKGFGFSLRGGREY---NMDL 1147
F F K A++ Q TVE+++G G S+ GG ++ +
Sbjct: 1802 FTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPI 1861
Query: 1148 YVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL-FLKRGDG 1206
++ + G A + K+R+GD I+ I G +T+ M H++A+ L+KN + + + GD
Sbjct: 1862 FIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDV 1921
Query: 1207 SV 1208
SV
Sbjct: 1922 SV 1923
Score = 81.6 bits (200), Expect = 5e-15
Identities = 138/679 (20%), Positives = 243/679 (35%), Gaps = 124/679 (18%)
Query: 643 TVHIVKGPMGFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTH 699
T++I KG G T++ + G G V+ I+ R + GD I+ +N+++ ++T+
Sbjct: 1008 TINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
Query: 700 NQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTAS 759
Q ML +R L P P E + S S
Sbjct: 1068 AQARAML-------------RRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF 1114
Query: 760 PSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRK 819
S++ + +PE P E ++++ + W Q R + LWR+
Sbjct: 1115 SSYTGRDIPELPEREEGEGEESELQNTA----YSNWNQPRR-------------VELWRE 1157
Query: 820 ET-GFGFRILGGNEPGEP---------IYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
+ G I+GG G I+I H++ A +G L+ GD ++ VDG +
Sbjct: 1158 PSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLR 1217
Query: 870 GKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN---EVPSPASSHH-------SSN 919
SH+ V+ +++A VVF V N + P P+ H+ SS
Sbjct: 1218 DASHEQAVEAIRKAGNP----------VVFMVQSIINRPRKSPLPSLLHNLYPKYNFSST 1267
Query: 920 QP--------------ASLTEEKRTPQGS-----------------QNSLNTVSSGSGST 948
P S +E ++ P S Q+S + +S
Sbjct: 1268 NPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKE 1327
Query: 949 SGIGSGGGGGSGVVSTVV-QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPH 1007
G T+ + + +E+ +G + G G + + R M
Sbjct: 1328 DEFGYSWKNIRERYGTLTGELHMIELEKGHS-GLGLSLAGNKDRSR-----------MSV 1375
Query: 1008 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1067
I I A + G+L++ D +L +NG + +SH + ++IK A + V + I ++
Sbjct: 1376 FIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDA 1435
Query: 1068 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1127
N + + + + Q E TT FK Q +EL
Sbjct: 1436 VNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLSSFKNVQ--------HLELP 1487
Query: 1128 RGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAI 1187
+ G G ++ + + + L E G A G++++GD+IL ++ E + I
Sbjct: 1488 KDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFI 1546
Query: 1188 ELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYP 1247
L+K V+L + + P+ G A+G E + P S P
Sbjct: 1547 SLLKTAKMTVKLTIHAEN---PDSQAVPSAAGAASG-----EKKNSSQSLMVPQSGSPEP 1598
Query: 1248 PDLHKSSPHGEKRAHARDP 1266
+ +S A DP
Sbjct: 1599 ESIRNTSRSSTPAIFASDP 1617
Score = 78.6 bits (192), Expect = 4e-14
Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)
Query: 822 GFGFRILG--GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 877
G GF ++G GE I++ I A DGRL+ D+++ ++G + +HQ +
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 878 QLMQQAAKQGHVNLTVRR-KVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN 936
++Q+A + V L + R + V + PS AS+ + + P
Sbjct: 207 SILQKA--KDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH--------ME 256
Query: 937 SLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 996
++ V+ GSG G G GG +GV+ + P
Sbjct: 257 TIELVNDGSGL--GFGIIGGKATGVIVKTILP---------------------------- 286
Query: 997 TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1056
G AD+ G+L GD IL + + S + ++++ GN
Sbjct: 287 ------------------GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNR 328
Query: 1057 VTLRIIPG--DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQ 1114
V L I G +E + T L IT + +P+ T E R + Q
Sbjct: 329 VKLMIARGAIEERTAPTALG-------ITLSSSPTS--TPELRVDA-----------STQ 368
Query: 1115 ATQEQDFYTVELERGAKGFGFSLRG----GREYNMDLYVLRLAEDGPAERCGKMRIGDEI 1170
+E + + VEL + +G G ++ G + ++V + + E G+++IGD+I
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428
Query: 1171 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1203
+ ++G + + +A+E++++ G+ V L L R
Sbjct: 429 IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
Score = 77.8 bits (190), Expect = 7e-14
Identities = 137/631 (21%), Positives = 238/631 (37%), Gaps = 109/631 (17%)
Query: 451 VPLQGKPFFTRNPSELKGKFIHT-----------KLRKSSRGFGFTVVGGDEPDEFLQIK 499
+P P +R+PS H+ +L G GF ++GG +K
Sbjct: 225 LPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVI--VK 282
Query: 500 SLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559
+++ G A G++ +GD I+ + DT + G + QV ++ + G V L + RG
Sbjct: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQ--CGNRVKLMIARG---- 336
Query: 560 FDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN 619
AI ++ P++ S+
Sbjct: 337 --------------AIEER-----------------------------TAPTALGITLSS 353
Query: 620 SSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGG-----GGQRVKQIVDS 674
S P V ++ + E V + K G G TIA G G VK I S
Sbjct: 354 SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKS 413
Query: 675 PRCR---GLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSP 731
++ GD I+ V+ N+Q T+ Q V++L G V L + R G+ +
Sbjct: 414 SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH--TGQTVLLTLMRRGMKQEAELM 471
Query: 732 KSQPLERKDSQ----NSSQHSVSSHRSLHTASPSHSTQVLPE----FPPAEAQAPDQTDS 783
+ + KD+ N+S + + S + +T +LP +P A+ + D+
Sbjct: 472 SREDV-TKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDA 530
Query: 784 SGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIV 843
+K + + R M N F G G+ +I ++
Sbjct: 531 ---QKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHH-----FIRSVL 582
Query: 844 PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPK 903
P G G+L SGDEL+ V+G ++G++HQ VV ++++ + V + R+ V P
Sbjct: 583 PEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIE--VTMVCCRRTV--PPT 638
Query: 904 TENEVPSPASSHHSSNQPASLTEEKRTPQGS-QNSLNTVSSGSGSTSGIGSGGGGGSGVV 962
T++E+ S LTE+ G S T T S + +
Sbjct: 639 TQSELDS------LDLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLA 692
Query: 963 STVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCG 1022
+E+ +G ++G GF I+ + +T I ++ G A++ G
Sbjct: 693 MWEAGIQHIELEKG-SKGLGFSILDYQDPIDPASTV--------IIIRSLVPGGIAEKDG 743
Query: 1023 KLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1053
+L GDR++ VN ++ N S + V +K A
Sbjct: 744 RLLPGDRLMFVNDVNLENSSLEEAVEALKGA 774
Score = 72.8 bits (177), Expect = 2e-12
Identities = 120/513 (23%), Positives = 193/513 (37%), Gaps = 117/513 (22%)
Query: 436 VIPNHPPSNPEPAREVPLQGKP-FFTRNPSE---LKGKFIHTKLRKSSRGFGFTVVGG-D 490
++P PE R P F +P+ + G ++ K G G ++VGG D
Sbjct: 1589 MVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1648
Query: 491 EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDL 550
+ I + +G A DG++ GD I+ VN + TH + + + + P V L
Sbjct: 1649 TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTP--QRVRL 1706
Query: 551 ELCRGYPLPFDPDDPNTSLVTSVAILDKEP---------------------IIVNGQETY 589
L R P+ ++ +L L K+P I+ G
Sbjct: 1707 TLYRD-EAPYKEEEVCDTLTIE---LQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADA 1762
Query: 590 DSPASHSSKTGKVNGMKDARPSSPADVA--------SNSSHGYPNDTVSLASSIATQPE- 640
D + VNG +D R ++ VA S SS +P S + S+ + +
Sbjct: 1763 DGRLMQGDQILMVNG-EDVRNATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKK 1821
Query: 641 ---------LITVHIVKGPM-GFGFTIADSPGGGGQRVKQIVDSPRCRG-------LKEG 683
L TV + KGP G +IA G V + G L+ G
Sbjct: 1822 NALASEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVG 1881
Query: 684 DLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQN 743
D IV + + + +TH Q V++L GS +V G + V
Sbjct: 1882 DRIVTICGTSTEGMTHTQAVNLLKNA-SGSIEMQVVAGGDVSV----------------- 1923
Query: 744 SSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYE 803
V+ H+ +S T + S S+++
Sbjct: 1924 -----VTGHQQEPASSSLSFTGLT------------------------------SSSIFQ 1948
Query: 804 NRLPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PIYIGHIVPLGAADTDGRLRSGDEL 860
+ L Q + I L R G GF I+GG + G+ PIY+ + GAA DGRL+ GD++
Sbjct: 1949 DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQI 2008
Query: 861 ICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 893
I V+G + G +H+ V ++++ +G V L V
Sbjct: 2009 IAVNGQSLEGVTHEEAVAILKRT--KGTVTLMV 2039
Score = 67.0 bits (162), Expect = 1e-10
Identities = 65/264 (24%), Positives = 116/264 (43%), Gaps = 44/264 (16%)
Query: 972 EIRRGENEGFGFVIVS--SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
E+ + + G GF +V S +R E G + I EGS A R G+LK D+
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENRGELGIF-----------VQEIQEGSVAHRDGRLKETDQ 187
Query: 1030 ILAVNGCSITNK-SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1088
ILA+NG ++ +H ++++++A +TV L I G + ++ + + +P
Sbjct: 188 ILAINGQALDQTITHQQAISILQKAKDTVQLVIARG----------SLPQLVSPIVSRSP 237
Query: 1089 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1148
S T + Q + T+EL G GF + GG+ +
Sbjct: 238 SAASTISAHSNPVHWQHME---------------TIELVNDGSGLGFGIIGGKATGV--I 280
Query: 1149 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV 1208
V + G A++ G++ GD IL+I M + ++++ G RV+L + R G++
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIAR--GAI 338
Query: 1209 PEYD-PSSDRHGPATGPQGVPEVR 1231
E P++ ++ P PE+R
Sbjct: 339 EERTAPTALGITLSSSPTSTPELR 362
Score = 65.9 bits (159), Expect = 3e-10
Identities = 103/451 (22%), Positives = 180/451 (39%), Gaps = 73/451 (16%)
Query: 474 KLRKSSRGFGFTVVG--GDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
+L K+ +G G T+ G GD+ E + +KS+ DG+++ GD I++V+ T + G
Sbjct: 379 ELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
Query: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNG-QET 588
T+ Q V++ + G +V L L R + + + + VT A D P+ + +E
Sbjct: 439 FTNQQAVEVLRHT--GQTVLLTLMRR-GMKQEAELMSREDVTKDA--DLSPVNASIIKEN 493
Query: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP---------NDTVSLASSIATQ- 638
Y+ S T N + GYP D +++ T+
Sbjct: 494 YEKDEDFLSSTRNTN------------ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKW 541
Query: 639 -------PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVE 688
E++ H+ K G I+ G ++ ++ + P L GD ++E
Sbjct: 542 QRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLE 601
Query: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHS 748
VN + H VV++L E P EVT++ R +P P + L+ D + + +
Sbjct: 602 VNGITLLGENHQDVVNILKELP--IEVTMVCCRRTVP-PTTQSELDSLDLCDIELTEKPH 658
Query: 749 VSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPD 808
V + ++ + + S ++ P +W
Sbjct: 659 VDLGEFIGSSETEDPVLAMTD-----------AGQSTEEVQAPLAMWEAGI--------- 698
Query: 809 YQEQDIFLWRKETGFGFRILGGNEPGEP----IYIGHIVPLGAADTDGRLRSGDELICVD 864
Q I L + G GF IL +P +P I I +VP G A+ DGRL GD L+ V+
Sbjct: 699 ---QHIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVN 755
Query: 865 GTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 895
+ S + V+ + + A G V + V +
Sbjct: 756 DVNLENSSLEEAVEAL-KGAPSGTVRIGVAK 785
Score = 48.1 bits (113), Expect = 6e-05
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 45/264 (17%)
Query: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557
I+S++ +GP GK+ +GD ++ VN +LG H VV I + +PI V + CR
Sbjct: 578 IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI--EVTMVCCRRTV 635
Query: 558 LPFDPDDPNTSLVTSVAILDKEPI----IVNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
P + ++ + + + +K + + ET D V M DA S
Sbjct: 636 PPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETED----------PVLAMTDAGQS-- 683
Query: 614 ADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD-----SPGGGGQR 667
T + + +A + + + + KG G GF+I D P
Sbjct: 684 --------------TEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 668 VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
++ +V + + L GD ++ VN N++ + + V+ L P G+ V + V +
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGT-VRIGVAK--- 785
Query: 725 PVPKKSPKSQPLERKDSQNSSQHS 748
P+P + ++DS HS
Sbjct: 786 PLPLSPEEGYVSAKEDSFLYPPHS 809
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 119 bits (297), Expect = 3e-26
Identities = 156/665 (23%), Positives = 253/665 (38%), Gaps = 105/665 (15%)
Query: 418 QQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFT-----RNPSELKGKFIH 472
Q Q T+E E PP + PP + + FT + ++L G+
Sbjct: 1180 QNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGELHI 1239
Query: 473 TKLRKSSRGFGFTVVGGDEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531
+L K G G ++ G + + + + +GPAA DG+M GD ++ +N+ + G +
Sbjct: 1240 IELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRS 1299
Query: 532 HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591
H I ++ P + V L R + D N VT + P + Q +
Sbjct: 1300 HQNASAIIKTAP--SKVKLVFIR------NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEP 1351
Query: 592 PASHSSKTGKVNGMKDARPSSPADVASNS--SHGYPNDTVSLASSIATQPELITVHIVKG 649
+S + +V G+K S +A + YP + I P
Sbjct: 1352 ISSEEDGSVEV-GIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPA--------- 1401
Query: 650 PMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
+ T AD G GG + VD C + ++I+E++K
Sbjct: 1402 -SSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKG----------------- 1443
Query: 710 PKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPE 769
R GL + K PL +++ H + + ++
Sbjct: 1444 -----------RSGLGLSIVGGKDTPL----------NAIVIHEVYEEGAAARDGRLWAG 1482
Query: 770 FPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMY----ENRLPDYQEQDIFL--WRKETGF 823
E D +SS ++ + Q + E D + +IF +K+ G
Sbjct: 1483 DQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGR 1542
Query: 824 GFRI-LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882
G + + G G ++I IV GAAD DGRL GD+++ V+G + S + V +++
Sbjct: 1543 GLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
Query: 883 AAKQGHVNLTVRRKVV---FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN 939
A QG V L + R + T S HSS P+ G QN +
Sbjct: 1603 A--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP----VITGLQNLVG 1656
Query: 940 T--VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 997
T VS S SG T ++P VEI R ++ G I G+
Sbjct: 1657 TKRVSDPSQKNSG-------------TDMEPRTVEINRELSDALGISIAGG-----RGSP 1698
Query: 998 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1057
G+ +P I I A R KLKVGDRI+++NG + SH+D+VNL+K A +
Sbjct: 1699 LGD----IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRI 1754
Query: 1058 TLRII 1062
L+++
Sbjct: 1755 ILQVV 1759
Score = 104 bits (260), Expect = 5e-22
Identities = 86/294 (29%), Positives = 128/294 (43%), Gaps = 45/294 (15%)
Query: 968 PYDVEIRRGENEGFGFVIVSS---VSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKL 1024
P VEI R N G IV + R + G + +++E SPA + L
Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIK------QVLEDSPAGKTNAL 1119
Query: 1025 KVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITT 1084
K GD+IL V+G + N SHS+ V IK AGN V I SS ++ N A T
Sbjct: 1120 KTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVV--FIVQSLSSTPRVIPNVHNKANKIT 1177
Query: 1085 --THTPSQQGTQETRNTTKPKQESQFEFKA----PQATQEQDFYT--------------- 1123
+ +Q+ ++ + T P + +KA +E+D +T
Sbjct: 1178 GNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIRQRYADLPGEL 1237
Query: 1124 --VELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKN 1180
+ELE+ G G SL G ++ + M ++V+ + +GPA G+MRIGDE+LEIN +
Sbjct: 1238 HIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYG 1297
Query: 1181 MKHSRAIELIKNGGRRVRLFLKRGDGS----------VPEYDPSSDRHGPATGP 1224
H A +IK +V+L R + + VP PSS T P
Sbjct: 1298 RSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEP 1351
Score = 97.1 bits (240), Expect = 1e-19
Identities = 144/628 (22%), Positives = 239/628 (38%), Gaps = 132/628 (21%)
Query: 668 VKQIV-DSP--RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
+KQ++ DSP + LK GD I+EV+ ++Q +H++ V+ + G+ V +VQ
Sbjct: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA--GNPVVFIVQSLS- 1160
Query: 725 PVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ--TD 782
P+ P K + N +Q + +P PP + P + TD
Sbjct: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAP----------PPMKLPPPYKALTD 1210
Query: 783 SSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGE-PIYIGH 841
S + + + + R Y + LP + I L + + G G + G + I++
Sbjct: 1211 DSDENEEEDAFTDQKIRQRYAD-LPG-ELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVG 1268
Query: 842 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAV 901
I P G A DGR+R GDEL+ ++ + G+SHQ +++ A + + V +
Sbjct: 1269 INPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQM 1328
Query: 902 PKTENEVPSPASS---HHSSNQPASLTEE-------KRTPQ------------------- 932
T VPS + S S +P S E+ K+ P+
Sbjct: 1329 AVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTK 1388
Query: 933 ---GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVST------VV--QPYDVEIRRGENEGF 981
SQ +S ST +G GG +S +V Q +EI +G + G
Sbjct: 1389 VSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS-GL 1447
Query: 982 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1041
G IV P NA V I + E A R G+L GD+IL VNG + N
Sbjct: 1448 GLSIVGGKDTPL------NAIV-----IHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496
Query: 1042 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1101
SH + + +++ V L + R+
Sbjct: 1497 SHEEAITALRQTPQKVRLVVY----------------------------------RDEAH 1522
Query: 1102 PKQESQFEFKAPQATQEQDFYTVELERGA-KGFGFSLRGGREYNMDLYVLRLAEDGPAER 1160
+ E E + V+L++ A +G G S+ G R +++ + + G A+
Sbjct: 1523 YRDEENLE-----------IFPVDLQKKAGRGLGLSIVGKRN-GSGVFISDIVKGGAADL 1570
Query: 1161 CGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGP 1220
G++ GD+IL +NGE +N ++K V+L + R R G
Sbjct: 1571 DGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGR------------LRAGS 1618
Query: 1221 ATGPQGVPEVRAGPDRRQHPSLESSYPP 1248
T + + G + H S S+ P
Sbjct: 1619 WTSARTTSQNSQGSQQSAHSSCHPSFAP 1646
Score = 93.6 bits (231), Expect = 1e-18
Identities = 109/444 (24%), Positives = 189/444 (42%), Gaps = 97/444 (21%)
Query: 798 SRSMYENRLPDY----QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGR 853
S S+ + LP+ +++ L +G GF I+GG G + + IVP G AD DGR
Sbjct: 229 SSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGR 286
Query: 854 LRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPAS 913
L++GD ++ + GT V G + + V Q+++ V + V R P + V PA
Sbjct: 287 LQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNS--VRMLVARD-----PAGDISVTPPA- 338
Query: 914 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 973
PA+L +L TV+S G G S++ + Y+VE+
Sbjct: 339 -------PAALPV----------ALPTVASK-------------GPGSDSSLFETYNVEL 368
Query: 974 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1033
R + + G IV V G G + II GS A G ++V D+I+AV
Sbjct: 369 VRKDGQSLGIRIVGYVGTSHTGEASGIY-------VKSIIPGSAAYHNGHIQVNDKIVAV 421
Query: 1034 NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN--------------------ATLL 1073
+G +I ++ D+V +++ AG V L ++ SS+ A L
Sbjct: 422 DGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLKPPALFL 481
Query: 1074 TNA---------------EKIATITTTHTPSQQGTQETRNTTKPKQESQFE------FKA 1112
T A E+I T+ + + + ++ ++ + + +S++E ++
Sbjct: 482 TGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEV 541
Query: 1113 PQATQE-QDFYTVELERGAKGFGF-SLRGGRE---YNMDLYVLRLAEDGPAERCGKMRIG 1167
AT + Q EL++ +K +LR G E ++ Y+ + GP + G ++
Sbjct: 542 MVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPE 601
Query: 1168 DEILEINGETTKNMKHSRAIELIK 1191
DE+LE+NG A+ +K
Sbjct: 602 DELLEVNGMQLYGKSRREAVSFLK 625
Score = 76.3 bits (186), Expect = 2e-13
Identities = 169/847 (19%), Positives = 312/847 (36%), Gaps = 152/847 (17%)
Query: 408 QQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPE-PAREVPLQGKPFFTRNPSEL 466
Q+++Q+ Q Q SA + + E P RE +G+ T N S
Sbjct: 1007 QRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPERE---EGEGEETPNFSHW 1063
Query: 467 KGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQ---------IKSLVLDGPAALDGKMETGD 517
I R+ + G ++VGG + L+ IK ++ D PA ++TGD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
Query: 518 VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILD 577
I+ V+ + +H++ V+ ++ G P+ F +S + +
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKN------------AGNPVVFIVQS-LSSTPRVIPNVH 1170
Query: 578 KEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVS---LASS 634
+ + G + D+ + G P A + +S D + +
Sbjct: 1171 NKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKA-LTDDSDENEEEDAFTDQKIRQR 1229
Query: 635 IATQP-ELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG-----LKEGDLIVE 688
A P EL + + K G G ++A + + + +P ++ GD ++E
Sbjct: 1230 YADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLE 1289
Query: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRG----------GLPVPKKSPKS----- 733
+N + + +H ++ P S+V L+ R PVP SP S
Sbjct: 1290 INNQILYGRSHQNASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQS 1347
Query: 734 --QPLERKD------------SQNSSQHSVSS-HRSLHTASPSHSTQVLPEFPPAEAQAP 778
+P+ ++ S + +VS + + S S+Q +P P + +
Sbjct: 1348 GTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHST 1407
Query: 779 DQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNE-PGEPI 837
D + P + + + QE I + + +G G I+GG + P I
Sbjct: 1408 DADFTGYGGFQAPLSVDPATCPIVPG-----QEMIIEISKGRSGLGLSIVGGKDTPLNAI 1462
Query: 838 YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 897
I + GAA DGRL +GD+++ V+G + SH+ + ++Q ++ V L V R
Sbjct: 1463 VIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK--VRLVVYRDE 1520
Query: 898 VFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSG-STSGIGSGGG 956
+ E+ P L +K+ +G S+ +GSG S I G
Sbjct: 1521 AHYRDEENLEI-----------FPVDL--QKKAGRGLGLSIVGKRNGSGVFISDIVK--G 1565
Query: 957 GGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGS 1016
G + + ++Q + GE+ + + S+ T A + +IGR+ GS
Sbjct: 1566 GAADLDGRLIQGDQILSVNGED-------MRNASQETVATILKCAQGLVQLEIGRLRAGS 1618
Query: 1017 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNA 1076
R + N +HS S A ++T
Sbjct: 1619 --------WTSARTTSQNSQGSQQSAHSSC-------------------HPSFAPVITGL 1651
Query: 1077 EKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERG-AKGFGF 1135
+ + T+ + P Q++ P+ TVE+ R + G
Sbjct: 1652 QNLV--------------GTKRVSDPSQKNSGTDMEPR--------TVEINRELSDALGI 1689
Query: 1136 SLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
S+ GGR ++ +++ + G A R K+++GD I+ ING+ + H+ + L+KN
Sbjct: 1690 SIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKN 1749
Query: 1193 GGRRVRL 1199
R+ L
Sbjct: 1750 AYGRIIL 1756
Score = 73.6 bits (179), Expect = 1e-12
Identities = 84/407 (20%), Positives = 155/407 (38%), Gaps = 94/407 (23%)
Query: 822 GFGFRILG---GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 877
G GF ++ N I++ + P AD D RL+ D+++ ++ TP+ SHQ +
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 878 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS 937
L+QQ G + L V R+ V T +SS + + P ++ G
Sbjct: 204 ALLQQTT--GSLRLIVAREPVHTKSST-------SSSLNDTTLPETVC------WGHVEE 248
Query: 938 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 997
+ ++ GSG G G GG SGVV
Sbjct: 249 VELINDGSGL--GFGIVGGKTSGVV----------------------------------- 271
Query: 998 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1057
+ I+ G ADR G+L+ GD IL + G ++ + + +++ GN+V
Sbjct: 272 -----------VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSV 320
Query: 1058 TLRIIPGDESSNATLLTNAEK-----IATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1112
+ ++ D + + ++ A + T+ + S ET N +++ Q
Sbjct: 321 RM-LVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQ----- 374
Query: 1113 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1172
G + G+ +YV + A G +++ D+I+
Sbjct: 375 --------------SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
Query: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFL--KRGDGSVPEYDPSSDR 1217
++G + + +E+++N G+ V L L ++ S +P SDR
Sbjct: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDR 467
Score = 73.2 bits (178), Expect = 2e-12
Identities = 104/546 (19%), Positives = 206/546 (37%), Gaps = 109/546 (19%)
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWA 796
+R++ ++ + + R + AS +++ + + + P++ + G++ P+ F W
Sbjct: 1007 QRREQEDLPLYQHQATRVISKAS-AYTGMLSSRYATDTCELPEREEGEGEETPN-FSHWG 1064
Query: 797 QSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGN---------EPGEPIYIGHIVPLGA 847
R + R P+ G I+GG E + I+I ++
Sbjct: 1065 PPRIVEIFREPN------------VSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSP 1112
Query: 848 ADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 907
A L++GD+++ V G + SH V+ ++ A + +P N+
Sbjct: 1113 AGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNK 1172
Query: 908 VPSPASSHHSSNQPASLTEEKRTPQG-SQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV 966
++ + NQ E+K QG + + T + +
Sbjct: 1173 -----ANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEEDAFTDQKIR 1227
Query: 967 QPYD--------VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPA 1018
Q Y +E+ + +N G G + + R +G EG PA
Sbjct: 1228 QRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSRMSI----------FVVGINPEG-PA 1275
Query: 1019 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLT---- 1074
G++++GD +L +N + +SH + +IK A + V L I +++ N +T
Sbjct: 1276 AADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPV 1335
Query: 1075 -----NAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ---------- 1119
++ + + T + + G+ E P+ ES F+ Q Q++
Sbjct: 1336 PSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESES-FKLAVSQMKQQKYPTKVSFSSQ 1394
Query: 1120 ---------------DF------------------------YTVELERGAKGFGFSLRGG 1140
DF +E+ +G G G S+ GG
Sbjct: 1395 EIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGG 1454
Query: 1141 REYNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
++ ++ V+ + E+G A R G++ GD+ILE+NG +N H AI ++ ++VRL
Sbjct: 1455 KDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRL 1514
Query: 1200 FLKRGD 1205
+ R +
Sbjct: 1515 VVYRDE 1520
Score = 65.9 bits (159), Expect = 3e-10
Identities = 71/266 (26%), Positives = 110/266 (41%), Gaps = 48/266 (18%)
Query: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
++I R G GF +V+ S+ G + + + GS ADR +LK D+I
Sbjct: 135 IDIERPSTGGLGFSVVALRSQ-----NLGKVDIFVKD----VQPGSVADRDQRLKENDQI 185
Query: 1031 LAVNGCSIT-NKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
LA+N + N SH + L+++ T +LR+I E HT S
Sbjct: 186 LAINHTPLDQNISHQQAIALLQQT--TGSLRLIVAREP-----------------VHTKS 226
Query: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1149
T + N T P+ VEL G GF + GG+ + V
Sbjct: 227 S--TSSSLNDTT----------LPETVCWGHVEEVELINDGSGLGFGIVGGK--TSGVVV 272
Query: 1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVP 1209
+ G A+R G+++ GD IL+I G + M + ++++N G VR+ + R P
Sbjct: 273 RTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARD----P 328
Query: 1210 EYDPSSDRHGPATGPQGVPEVRA-GP 1234
D S PA P +P V + GP
Sbjct: 329 AGDISVTPPAPAALPVALPTVASKGP 354
Score = 63.5 bits (153), Expect = 1e-09
Identities = 53/192 (27%), Positives = 84/192 (43%), Gaps = 21/192 (10%)
Query: 1007 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL---RIIP 1063
H I I+ G P D G L+ D +L VNG + KS + V+ +KE TL R +
Sbjct: 581 HYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLF 640
Query: 1064 GDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1123
DE+S + + T T P + T+ + + +P+
Sbjct: 641 DDEAS----VDEPRR----TETSLPETEVDHNMDVNTEEDDDGELALWSPEVK------I 686
Query: 1124 VELERGAKGFGFSL---RGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTK 1179
VEL + KG GFS+ + + + V+R L DG AER G + GD ++ +N
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746
Query: 1180 NMKHSRAIELIK 1191
N + A+E++K
Sbjct: 747 NTSLAEAVEILK 758
Score = 51.2 bits (121), Expect = 7e-06
Identities = 35/109 (32%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 474 KLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
+L K +G GF+++ +P + + I+SLV DG A G + GD +VSVN+ C+
Sbjct: 688 ELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDN 747
Query: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK 578
+ A+ V+I +++P G V L +C+ PL D ++ + ++ S + DK
Sbjct: 748 TSLAEAVEILKAVPPGL-VHLGICK--PLVEDNEEESCYILHSSSNEDK 793
Score = 48.5 bits (114), Expect = 5e-05
Identities = 127/616 (20%), Positives = 215/616 (34%), Gaps = 133/616 (21%)
Query: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
G +L G GF +VGG + ++++V G A DG+++TGD I+ + T V
Sbjct: 244 GHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNV 301
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G T QV ++ ++ G SV + + R DP
Sbjct: 302 QGMTSEQVAQVLRN--CGNSVRMLVAR------DP------------------------- 328
Query: 588 TYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIV 647
G ++ A + P + + +S G +D+ E V +V
Sbjct: 329 -----------AGDISVTPPAPAALPVALPTVASKGPGSDSSLF--------ETYNVELV 369
Query: 648 -KGPMGFGFTIADSPG------GGGQRVKQIVDSPRC---RGLKEGDLIVEVNKKNVQAL 697
K G I G G VK I+ ++ D IV V+ N+Q
Sbjct: 370 RKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGF 429
Query: 698 THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHT 757
++ VV++L + +TL+ + K S + PLE + + + T
Sbjct: 430 ANHDVVEVLRNAGQVVHLTLVRR-------KTSSSTSPLEPPSDRGTVVEPLKPPALFLT 482
Query: 758 ASPSHSTQVLPEFPPAEAQAP----DQTDSSGQKKPDPFKIWAQSRSMYENRL-PDYQ-- 810
+ T V E + + D + + + P + +S +EN L PDY+
Sbjct: 483 GAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLLGPDYEVM 542
Query: 811 ----------EQDIFLWRKETGFGFRILGGNEPG--EPIYIGHIVPLGAADTDGRLRSGD 858
+ ++ + K LG YI IV G DT G L+ D
Sbjct: 543 VATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPED 602
Query: 859 ELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSP---ASSH 915
EL+ V+G + GKS + V ++ EVP P
Sbjct: 603 ELLEVNGMQLYGKSRREAVSFLK-------------------------EVPPPFTLVCCR 637
Query: 916 HSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRR 975
+ AS+ E +RT + SL G + S V+ ++ ++
Sbjct: 638 RLFDDEASVDEPRRT----ETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVEL-VKD 692
Query: 976 GENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNG 1035
+ GF + P I ++ A+R G L GDR+++VN
Sbjct: 693 CKGLGFSILDYQDPLDPTRSVIV----------IRSLVADGVAERSGGLLPGDRLVSVNE 742
Query: 1036 CSITNKSHSDIVNLIK 1051
+ N S ++ V ++K
Sbjct: 743 YCLDNTSLAEAVEILK 758
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 1059 LRIIPGDESSNAT-----LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ-FEFKA 1112
L IP D S+N LL + T H PS T PK ++ F
Sbjct: 64 LNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVI 123
Query: 1113 PQATQEQDFYTVELERGAKG-FGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGD 1168
Q Q + +++ER + G GFS+ R N+ D++V + A+R +++ D
Sbjct: 124 QQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKEND 183
Query: 1169 EILEIN-GETTKNMKHSRAIELIKNGGRRVRLFLKR 1203
+IL IN +N+ H +AI L++ +RL + R
Sbjct: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 98.6 bits (244), Expect = 4e-20
Identities = 94/295 (31%), Positives = 138/295 (46%), Gaps = 62/295 (21%)
Query: 1045 DIVNLIKEAGNTVTLR---IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1101
D+ L++ AG T+ LR + +S++ + + ATI H P Q ET N
Sbjct: 47 DVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVD-HRP-QHRWLETCNA-- 102
Query: 1102 PKQESQFEFK-APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPA 1158
P Q Q + + AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA
Sbjct: 103 PPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPA 162
Query: 1159 ERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRH 1218
+RCG++ +GD +L INGE+T+ + H++A+E I+ GG ++ L ++R P
Sbjct: 163 QRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR---------PLETHP 213
Query: 1219 GPATGPQGVPEVRAG-----PDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYS 1273
G P+GV E R G PDR P + GSR S
Sbjct: 214 GK---PRGVGEPRKGVVPSWPDRSPDPG---------------------GPEVTGSRSSS 249
Query: 1274 RQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRRE 1328
+H + T+ K G+ P +PE AAA+GP PE+R E
Sbjct: 250 TSLVQHPP-SRTTLKKTRGSPEP---SPE----------AAADGPTVSPPERRAE 290
Score = 56.2 bits (134), Expect = 2e-07
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALD 510
+QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA
Sbjct: 107 IQGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRC 165
Query: 511 GKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
G++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 216
Score = 47.0 bits (110), Expect = 1e-04
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 36/163 (22%)
Query: 969 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1028
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VGD
Sbjct: 124 FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 172
Query: 1029 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------IPG-----------------D 1065
+L +NG S +H+ V I+ G + L I PG D
Sbjct: 173 LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPD 232
Query: 1066 ESSN--ATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1106
S + +T + +T H PS+ ++TR + +P E+
Sbjct: 233 RSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 275
Score = 45.1 bits (105), Expect = 5e-04
Identities = 52/189 (27%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
Query: 697 LTHNQVVDMLVECPKGSEVTLLVQR-----------------GGLPV-PKKSPKSQPLER 738
LTH Q V+ + G ++ L+++R G +P P +SP E
Sbjct: 185 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
Query: 739 KDSQNSSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPD 790
S++SS V S T SP S + + P P E +A D D P
Sbjct: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPG 301
Query: 791 PFKIWAQSR 799
P+ + ++ R
Sbjct: 302 PWLVPSEER 310
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 96.3 bits (238), Expect = 2e-19
Identities = 106/503 (21%), Positives = 203/503 (40%), Gaps = 59/503 (11%)
Query: 731 PKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD 790
P Q + + S Q S S SL + ++++ + + + ++DSS + P
Sbjct: 991 PPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPG 1050
Query: 791 PFKIWAQSRSMYENRLPDYQEQDIFLWRKET--GFGFRILGGNEPGE---PIYIGHIVPL 845
+ + +E + +K+ G GF+I+GG + G I+I + P
Sbjct: 1051 QAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPG 1110
Query: 846 GAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTE 905
G AD DG L+ GD LI V+ + G SH ++++Q A + + ++ ++ + VP T
Sbjct: 1111 GPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTP 1170
Query: 906 NEVPSPASSHHSSN---QPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVV 962
+ + ++ + Q +++ + S+ +L +S S G GG G +
Sbjct: 1171 VHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLRHISENS-----FGPSGGLREGSL 1225
Query: 963 STVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCG 1022
S+ + R E+ +S+S+ + F + + + GSP+
Sbjct: 1226 SS-------QDSRTES--------ASLSQSQVNGFFASHLGDQTWQESQ--HGSPSPSVI 1268
Query: 1023 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATI 1082
+ S T K V + G++ + AT ++ +
Sbjct: 1269 SKATEKETFTDSNQSKTKKPGISDVTDYSDRGDS---------DMDEATYSSSQDH---- 1315
Query: 1083 TTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGRE 1142
TP Q+ + + K F+ + + D + VEL + G S+ GG
Sbjct: 1316 ---QTPKQESSSSVNTSNK----MNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTGGVN 1368
Query: 1143 YNM---DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
++ +YV + G AE G++ GD +L +NG + + H +A+E ++N G+ V L
Sbjct: 1369 TSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHL 1428
Query: 1200 FLKRGDGSVPEYDPSSDRHGPAT 1222
L++G P+S H P T
Sbjct: 1429 LLEKGQ------SPTSKEHVPVT 1445
Score = 89.4 bits (220), Expect = 2e-17
Identities = 147/675 (21%), Positives = 254/675 (37%), Gaps = 143/675 (21%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 1077 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1136
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P D+ L P P+T + + N + Y
Sbjct: 1137 SHHAAIEILQNAP----EDVTLVISQPKEKISKVPSTPVH-----------LTNEMKNYM 1181
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
+S+ M+D+ S S+ H + T+ HI +
Sbjct: 1182 KKSSY---------MQDSAIDS-----SSKDHHWSRGTLR--------------HISENS 1213
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1214 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1248
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ------HSVSSHRSLHTASPSHST 764
+ T + G P P K+ E N S+ V+ + + +T
Sbjct: 1249 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEAT 1308
Query: 765 QVLPEFPPAEAQAPDQTDSSGQKKPDP--FKIWAQSRSMYENRLPDYQEQDIF---LWRK 819
+ + Q P Q SS + FK ++ S + DIF L +
Sbjct: 1309 YSSSQ----DHQTPKQESSSSVNTSNKMNFKTFSSSPP---------KPGDIFEVELAKN 1355
Query: 820 ETGFGFRILGGNEPGEP---IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 876
+ G + GG IY+ ++P GAA++DGR+ GD ++ V+G + G +H+
Sbjct: 1356 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQA 1415
Query: 877 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP-ASLTEEKRTPQGSQ 935
V+ ++ + H+ L + SP S H P +L+++ QG +
Sbjct: 1416 VETLRNTGQVVHLLL--------------EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE 1461
Query: 936 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN-EGFGFVIVSSVSRPEA 994
T S V + E++ +N G GF S SR +
Sbjct: 1462 KVKKTTQVKD----------------YSFVTEENTFEVKLFKNSSGLGF----SFSRED- 1500
Query: 995 GTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAG 1054
A ++ ++ G PA GK+ VGD IL VNG S+ S ++++ ++
Sbjct: 1501 -NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTA 1559
Query: 1055 NTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQGTQETRNTTKPKQESQF 1108
V L R PG + LLT + A + ++ SQ E ++ + S
Sbjct: 1560 PEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDK 1619
Query: 1109 EFKAPQATQEQDFYT 1123
K ++ +D Y+
Sbjct: 1620 SKKQCKSPSRRDSYS 1634
Score = 74.3 bits (181), Expect = 8e-13
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 32/274 (11%)
Query: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1071
+I A+ G++ GDR+LAVNG S+ +H V ++ G V L + ++ + T
Sbjct: 1381 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL---EKGQSPT 1437
Query: 1072 LLTNAEKIATITTTHTPSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1130
+ T + +Q QG ++ + TT+ K S E++ + V+L + +
Sbjct: 1438 SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--------FVTEENTFEVKLFKNS 1489
Query: 1131 KGFGFSLRGGREYNMD--------LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1182
G GFS RE N+ + V +L PA GK+ +GD IL++NG + K +
Sbjct: 1490 SGLGFSF--SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1547
Query: 1183 HSRAIELIKNGGRRVRLFLKR-GDGSVPEYDPS--SDRHGPATGPQGVPEVRAGPDRRQH 1239
I ++ V L L R G +PE D + + PA Q +P + D Q
Sbjct: 1548 QQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPA---QVLP--NSSKDSSQP 1602
Query: 1240 PSLESSYPPDLHKSSPHGEKRAHARDPKGSREYS 1273
+E S D ++ S +K+ + P YS
Sbjct: 1603 SCVEQSTSSDENEMSDKSKKQ--CKSPSRRDSYS 1634
Score = 68.6 bits (166), Expect = 4e-11
Identities = 106/442 (23%), Positives = 172/442 (38%), Gaps = 115/442 (26%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1484 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1543
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1544 KGLSQQEVISALRGT--APEVFLLLCR--PPPGVLPEIDTALLTPLQ--SPAQVLPNSSK 1597
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1598 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1657
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1658 SALH--------------------QTLSNMVS---------------------QAQSHH- 1675
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1676 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1704
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKI-----------WAQSRSMYENRLPDYQ 810
+ + + P+ P ++ P Q++S+ D + I W ++ EN L D++
Sbjct: 1705 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1763
Query: 811 ---EQDIFLWRKETG-FGFRILGGNEPGEPIYIG---HIVPLGAADTDGRLRSGDELICV 863
E I L + E G GF + GN+ IG H V A +DGRL+ GD LI V
Sbjct: 1764 LEVELLITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKV 1818
Query: 864 DGTPVIGKSHQLVVQLMQQAAK 885
+ T V +H V L++ A+K
Sbjct: 1819 NDTDVTNMTHTDAVNLLRAASK 1840
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1017 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1802 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1846
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 81/338 (23%)
Query: 459 FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEF---LQIKSLVLDGPAALDGKMET 515
F+ +P + G +L K+ G +V GG + +K+++ G A DG++
Sbjct: 1337 FSSSPPK-PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1395
Query: 516 GDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAI 575
GD +++VN + G TH Q V+ ++ G V L L +G P VT
Sbjct: 1396 GDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQ----SPTSKEHVPVTPQCT 1449
Query: 576 LDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
L + G E K K +KD S
Sbjct: 1450 LSDQNAQGQGPE----------KVKKTTQVKD-------------------------YSF 1474
Query: 636 ATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRVKQIV---DSPRCRGLKEGDL 685
T+ V + K G GF+ I + RVK++ + + GD+
Sbjct: 1475 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1534
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR---GGLP-------VPKKSP-- 731
I++VN +++ L+ +V+ L +G+ EV LL+ R G LP P +SP
Sbjct: 1535 ILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQ 1590
Query: 732 --------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
SQP + S +S ++ +S SPS
Sbjct: 1591 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1628
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1690 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1740
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1741 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1790
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1791 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1846
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1847 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1898
Query: 613 PADVASN 619
A + N
Sbjct: 1899 VAAIEGN 1905
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/80 (28%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1773 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1828
Query: 1184 SRAIELIKNGGRRVRLFLKR 1203
+ A+ L++ + VRL + R
Sbjct: 1829 TDAVNLLRAASKTVRLVIGR 1848
>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
Length = 262
Score = 95.9 bits (237), Expect = 3e-19
Identities = 73/219 (33%), Positives = 105/219 (47%), Gaps = 49/219 (22%)
Query: 1112 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPAERCGKMRIGDE 1169
AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA+RCG++ +GD
Sbjct: 47 APKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDL 106
Query: 1170 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPE 1229
+L INGE+T+ + H++A+E I+ GG ++ L ++R P G P+GV E
Sbjct: 107 VLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR---------PLETHPGK---PRGVGE 154
Query: 1230 VRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKP 1289
R G DR P + GSR S +H + T+ K
Sbjct: 155 PRKGVDRSPDPG---------------------GPEVTGSRSSSTSLVQHPP-SRTTLKK 192
Query: 1290 DSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRRE 1328
G+ P +PE AAA+GP PE+R E
Sbjct: 193 TRGSPEP---SPE----------AAADGPTVSPPERRAE 218
Score = 55.5 bits (132), Expect = 4e-07
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 454 QGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALDG 511
QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA G
Sbjct: 41 QGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCG 99
Query: 512 KMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 100 RLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 149
Score = 48.9 bits (115), Expect = 4e-05
Identities = 40/158 (25%), Positives = 65/158 (41%), Gaps = 31/158 (19%)
Query: 969 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1028
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VGD
Sbjct: 57 FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 105
Query: 1029 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI--------------------IPGDESS 1068
+L +NG S +H+ V I+ G + L I +
Sbjct: 106 LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDP 165
Query: 1069 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1106
+T + +T H PS+ ++TR + +P E+
Sbjct: 166 GGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 203
Score = 46.2 bits (108), Expect = 2e-04
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)
Query: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 58 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
Query: 697 LTHNQVVDMLVECPKGSEVTLLVQR---------GGLPVPKK----SPKSQPLERKDSQN 743
LTH Q V+ + G ++ L+++R G+ P+K SP E S++
Sbjct: 118 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
Query: 744 SSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPDPFKIW 795
SS V S T SP S + + P P E +A D D P P+ +
Sbjct: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPGPWLVP 234
Query: 796 AQSR 799
++ R
Sbjct: 235 SEER 238
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 95.5 bits (236), Expect = 3e-19
Identities = 92/410 (22%), Positives = 170/410 (41%), Gaps = 57/410 (13%)
Query: 822 GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQ 878
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH ++
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 879 LMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN---QPASLTEEKRTPQGSQ 935
++Q A + + ++ ++ + VP T + + ++ + Q +++ + S+
Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1031
Query: 936 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAG 995
+L +S S G GG G +S+ + R E+ +S+S+ +
Sbjct: 1032 GTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQSQVN 1071
Query: 996 TTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1055
F + + + GSP+ + S T K V + G+
Sbjct: 1072 GFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1129
Query: 1056 TVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQA 1115
+ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1130 S---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFSSSP 1169
Query: 1116 TQEQDFYTVELERGAKGFGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGDEILE 1172
+ D + VEL + G S+ GG ++ +YV + G AE G++ GD +L
Sbjct: 1170 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1229
Query: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPAT 1222
+NG + + H +A+E ++N G+ V L L++G P+S H P T
Sbjct: 1230 VNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ------SPTSKEHVPVT 1273
Score = 89.4 bits (220), Expect = 2e-17
Identities = 147/675 (21%), Positives = 254/675 (37%), Gaps = 143/675 (21%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 905 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P D+ L P P+T + + N + Y
Sbjct: 965 SHHAAIEILQNAP----EDVTLVISQPKEKISKVPSTPVH-----------LTNEMKNYM 1009
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
+S+ M+D+ S S+ H + T+ HI +
Sbjct: 1010 KKSSY---------MQDSAIDS-----SSKDHHWSRGTLR--------------HISENS 1041
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1042 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1076
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ------HSVSSHRSLHTASPSHST 764
+ T + G P P K+ E N S+ V+ + + +T
Sbjct: 1077 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEAT 1136
Query: 765 QVLPEFPPAEAQAPDQTDSSGQKKPDP--FKIWAQSRSMYENRLPDYQEQDIF---LWRK 819
+ + Q P Q SS + FK ++ S + DIF L +
Sbjct: 1137 YSSSQ----DHQTPKQESSSSVNTSNKMNFKTFSSSPP---------KPGDIFEVELAKN 1183
Query: 820 ETGFGFRILGGNEPGEP---IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 876
+ G + GG IY+ ++P GAA++DGR+ GD ++ V+G + G +H+
Sbjct: 1184 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQA 1243
Query: 877 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP-ASLTEEKRTPQGSQ 935
V+ ++ + H+ L + SP S H P +L+++ QG +
Sbjct: 1244 VETLRNTGQVVHLLL--------------EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE 1289
Query: 936 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN-EGFGFVIVSSVSRPEA 994
T S V + E++ +N G GF S SR +
Sbjct: 1290 KVKKTTQVKD----------------YSFVTEENTFEVKLFKNSSGLGF----SFSRED- 1328
Query: 995 GTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAG 1054
A ++ ++ G PA GK+ VGD IL VNG S+ S ++++ ++
Sbjct: 1329 -NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTA 1387
Query: 1055 NTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQGTQETRNTTKPKQESQF 1108
V L R PG + LLT + A + ++ SQ E ++ + S
Sbjct: 1388 PEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDK 1447
Query: 1109 EFKAPQATQEQDFYT 1123
K ++ +D Y+
Sbjct: 1448 SKKQCKSPSRRDSYS 1462
Score = 74.3 bits (181), Expect = 8e-13
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 32/274 (11%)
Query: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1071
+I A+ G++ GDR+LAVNG S+ +H V ++ G V L + ++ + T
Sbjct: 1209 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL---EKGQSPT 1265
Query: 1072 LLTNAEKIATITTTHTPSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1130
+ T + +Q QG ++ + TT+ K S E++ + V+L + +
Sbjct: 1266 SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--------FVTEENTFEVKLFKNS 1317
Query: 1131 KGFGFSLRGGREYNMD--------LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1182
G GFS RE N+ + V +L PA GK+ +GD IL++NG + K +
Sbjct: 1318 SGLGFSF--SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1375
Query: 1183 HSRAIELIKNGGRRVRLFLKR-GDGSVPEYDPS--SDRHGPATGPQGVPEVRAGPDRRQH 1239
I ++ V L L R G +PE D + + PA Q +P + D Q
Sbjct: 1376 QQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPA---QVLP--NSSKDSSQP 1430
Query: 1240 PSLESSYPPDLHKSSPHGEKRAHARDPKGSREYS 1273
+E S D ++ S +K+ + P YS
Sbjct: 1431 SCVEQSTSSDENEMSDKSKKQ--CKSPSRRDSYS 1462
Score = 68.6 bits (166), Expect = 4e-11
Identities = 106/442 (23%), Positives = 172/442 (38%), Gaps = 115/442 (26%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1312 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1371
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1372 KGLSQQEVISALRGT--APEVFLLLCR--PPPGVLPEIDTALLTPLQ--SPAQVLPNSSK 1425
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1426 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1485
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1486 SALH--------------------QTLSNMVS---------------------QAQSHH- 1503
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1504 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1532
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKI-----------WAQSRSMYENRLPDYQ 810
+ + + P+ P ++ P Q++S+ D + I W ++ EN L D++
Sbjct: 1533 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1591
Query: 811 ---EQDIFLWRKETG-FGFRILGGNEPGEPIYIG---HIVPLGAADTDGRLRSGDELICV 863
E I L + E G GF + GN+ IG H V A +DGRL+ GD LI V
Sbjct: 1592 LEVELLITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKV 1646
Query: 864 DGTPVIGKSHQLVVQLMQQAAK 885
+ T V +H V L++ A+K
Sbjct: 1647 NDTDVTNMTHTDAVNLLRAASK 1668
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/108 (25%), Positives = 59/108 (54%), Gaps = 5/108 (4%)
Query: 1115 ATQEQDFYTVELERGAK-GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEI 1170
++ E++ V L++ AK G GF + GG + ++ +++ +A GPA+ G ++ GD +
Sbjct: 894 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 953
Query: 1171 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRH 1218
+ +N + + + H AIE+++N V L + + + + PS+ H
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKV-PSTPVH 1000
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1017 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1630 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1674
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 81/338 (23%)
Query: 459 FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEF---LQIKSLVLDGPAALDGKMET 515
F+ +P + G +L K+ G +V GG + +K+++ G A DG++
Sbjct: 1165 FSSSPPK-PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1223
Query: 516 GDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAI 575
GD +++VN + G TH Q V+ ++ G V L L +G P VT
Sbjct: 1224 GDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQ----SPTSKEHVPVTPQCT 1277
Query: 576 LDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
L + G E K K +KD S
Sbjct: 1278 LSDQNAQGQGPE----------KVKKTTQVKD-------------------------YSF 1302
Query: 636 ATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRVKQIV---DSPRCRGLKEGDL 685
T+ V + K G GF+ I + RVK++ + + GD+
Sbjct: 1303 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1362
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR---GGLP-------VPKKSP-- 731
I++VN +++ L+ +V+ L +G+ EV LL+ R G LP P +SP
Sbjct: 1363 ILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQ 1418
Query: 732 --------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
SQP + S +S ++ +S SPS
Sbjct: 1419 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1456
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1518 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1568
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1569 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1618
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1619 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1674
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1675 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1726
Query: 613 PADVASN 619
A + N
Sbjct: 1727 VAAIEGN 1733
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
V +++ G GF I+ G G + + I + G PAD G LK GDR+
Sbjct: 903 VNLKKDAKYGLGFQIIG-------GEKMGRLDLGI--FISSVAPGGPADLDGCLKPGDRL 953
Query: 1031 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
++VN S+ SH + +++ A VTL I
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/80 (28%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1601 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1656
Query: 1184 SRAIELIKNGGRRVRLFLKR 1203
+ A+ L++ + VRL + R
Sbjct: 1657 TDAVNLLRAASKTVRLVIGR 1676
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 95.5 bits (236), Expect = 3e-19
Identities = 92/410 (22%), Positives = 170/410 (41%), Gaps = 57/410 (13%)
Query: 822 GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQ 878
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 879 LMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN---QPASLTEEKRTPQGSQ 935
++Q A + + ++ ++ + VP T + + ++ + Q +++ + S+
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1222
Query: 936 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAG 995
+L +S S G GG G +S+ + R E+ +S+S+ +
Sbjct: 1223 GTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQSQVN 1262
Query: 996 TTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1055
F + + + GSP+ + S T K V + G+
Sbjct: 1263 GFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1320
Query: 1056 TVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQA 1115
+ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1321 S---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFSSSP 1360
Query: 1116 TQEQDFYTVELERGAKGFGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGDEILE 1172
+ D + VEL + G S+ GG ++ +YV + G AE G++ GD +L
Sbjct: 1361 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1420
Query: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPAT 1222
+NG + + H +A+E ++N G+ V L L++G P+S H P T
Sbjct: 1421 VNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ------SPTSKEHVPVT 1464
Score = 89.4 bits (220), Expect = 2e-17
Identities = 147/675 (21%), Positives = 254/675 (37%), Gaps = 143/675 (21%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P D+ L P P+T + + N + Y
Sbjct: 1156 SHHAAIEILQNAP----EDVTLVISQPKEKISKVPSTPVH-----------LTNEMKNYM 1200
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
+S+ M+D+ S S+ H + T+ HI +
Sbjct: 1201 KKSSY---------MQDSAIDS-----SSKDHHWSRGTLR--------------HISENS 1232
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1233 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1267
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ------HSVSSHRSLHTASPSHST 764
+ T + G P P K+ E N S+ V+ + + +T
Sbjct: 1268 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEAT 1327
Query: 765 QVLPEFPPAEAQAPDQTDSSGQKKPDP--FKIWAQSRSMYENRLPDYQEQDIF---LWRK 819
+ + Q P Q SS + FK ++ S + DIF L +
Sbjct: 1328 YSSSQ----DHQTPKQESSSSVNTSNKMNFKTFSSSPP---------KPGDIFEVELAKN 1374
Query: 820 ETGFGFRILGGNEPGEP---IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 876
+ G + GG IY+ ++P GAA++DGR+ GD ++ V+G + G +H+
Sbjct: 1375 DNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQA 1434
Query: 877 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP-ASLTEEKRTPQGSQ 935
V+ ++ + H+ L + SP S H P +L+++ QG +
Sbjct: 1435 VETLRNTGQVVHLLL--------------EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPE 1480
Query: 936 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN-EGFGFVIVSSVSRPEA 994
T S V + E++ +N G GF S SR +
Sbjct: 1481 KVKKTTQVKD----------------YSFVTEENTFEVKLFKNSSGLGF----SFSRED- 1519
Query: 995 GTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAG 1054
A ++ ++ G PA GK+ VGD IL VNG S+ S ++++ ++
Sbjct: 1520 -NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTA 1578
Query: 1055 NTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQGTQETRNTTKPKQESQF 1108
V L R PG + LLT + A + ++ SQ E ++ + S
Sbjct: 1579 PEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDK 1638
Query: 1109 EFKAPQATQEQDFYT 1123
K ++ +D Y+
Sbjct: 1639 SKKQCKSPSRRDSYS 1653
Score = 74.3 bits (181), Expect = 8e-13
Identities = 72/274 (26%), Positives = 120/274 (43%), Gaps = 32/274 (11%)
Query: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1071
+I A+ G++ GDR+LAVNG S+ +H V ++ G V L + ++ + T
Sbjct: 1400 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL---EKGQSPT 1456
Query: 1072 LLTNAEKIATITTTHTPSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1130
+ T + +Q QG ++ + TT+ K S E++ + V+L + +
Sbjct: 1457 SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--------FVTEENTFEVKLFKNS 1508
Query: 1131 KGFGFSLRGGREYNMD--------LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1182
G GFS RE N+ + V +L PA GK+ +GD IL++NG + K +
Sbjct: 1509 SGLGFSF--SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1566
Query: 1183 HSRAIELIKNGGRRVRLFLKR-GDGSVPEYDPS--SDRHGPATGPQGVPEVRAGPDRRQH 1239
I ++ V L L R G +PE D + + PA Q +P + D Q
Sbjct: 1567 QQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPA---QVLP--NSSKDSSQP 1621
Query: 1240 PSLESSYPPDLHKSSPHGEKRAHARDPKGSREYS 1273
+E S D ++ S +K+ + P YS
Sbjct: 1622 SCVEQSTSSDENEMSDKSKKQ--CKSPSRRDSYS 1653
Score = 68.6 bits (166), Expect = 4e-11
Identities = 106/442 (23%), Positives = 172/442 (38%), Gaps = 115/442 (26%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1503 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1562
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1563 KGLSQQEVISALRGT--APEVFLLLCR--PPPGVLPEIDTALLTPLQ--SPAQVLPNSSK 1616
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1617 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1676
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1677 SALH--------------------QTLSNMVS---------------------QAQSHH- 1694
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1695 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1723
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKI-----------WAQSRSMYENRLPDYQ 810
+ + + P+ P ++ P Q++S+ D + I W ++ EN L D++
Sbjct: 1724 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1782
Query: 811 ---EQDIFLWRKETG-FGFRILGGNEPGEPIYIG---HIVPLGAADTDGRLRSGDELICV 863
E I L + E G GF + GN+ IG H V A +DGRL+ GD LI V
Sbjct: 1783 LEVELLITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKV 1837
Query: 864 DGTPVIGKSHQLVVQLMQQAAK 885
+ T V +H V L++ A+K
Sbjct: 1838 NDTDVTNMTHTDAVNLLRAASK 1859
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/108 (25%), Positives = 59/108 (54%), Gaps = 5/108 (4%)
Query: 1115 ATQEQDFYTVELERGAK-GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEI 1170
++ E++ V L++ AK G GF + GG + ++ +++ +A GPA+ G ++ GD +
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 1171 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRH 1218
+ +N + + + H AIE+++N V L + + + + PS+ H
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKV-PSTPVH 1191
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1017 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1821 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1865
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 81/338 (23%)
Query: 459 FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEF---LQIKSLVLDGPAALDGKMET 515
F+ +P + G +L K+ G +V GG + +K+++ G A DG++
Sbjct: 1356 FSSSPPK-PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1414
Query: 516 GDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAI 575
GD +++VN + G TH Q V+ ++ G V L L +G P VT
Sbjct: 1415 GDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQ----SPTSKEHVPVTPQCT 1468
Query: 576 LDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
L + G E K K +KD S
Sbjct: 1469 LSDQNAQGQGPE----------KVKKTTQVKD-------------------------YSF 1493
Query: 636 ATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRVKQIV---DSPRCRGLKEGDL 685
T+ V + K G GF+ I + RVK++ + + GD+
Sbjct: 1494 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1553
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR---GGLP-------VPKKSP-- 731
I++VN +++ L+ +V+ L +G+ EV LL+ R G LP P +SP
Sbjct: 1554 ILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQ 1609
Query: 732 --------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
SQP + S +S ++ +S SPS
Sbjct: 1610 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1647
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1709 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1759
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1760 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1809
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1810 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1865
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1866 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1917
Query: 613 PADVASN 619
A + N
Sbjct: 1918 VAAIEGN 1924
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
V +++ G GF I+ G G + + I + G PAD G LK GDR+
Sbjct: 1094 VNLKKDAKYGLGFQIIG-------GEKMGRLDLGI--FISSVAPGGPADLDGCLKPGDRL 1144
Query: 1031 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
++VN S+ SH + +++ A VTL I
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/80 (28%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1792 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1847
Query: 1184 SRAIELIKNGGRRVRLFLKR 1203
+ A+ L++ + VRL + R
Sbjct: 1848 TDAVNLLRAASKTVRLVIGR 1867
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 90.5 bits (223), Expect = 1e-17
Identities = 93/415 (22%), Positives = 171/415 (41%), Gaps = 62/415 (14%)
Query: 822 GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQ 878
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 879 LMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSH---HSSNQPASLTEEKRTPQGSQ 935
++Q A + + ++ ++ + VP T + + ++ S Q +++ + S+
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1222
Query: 936 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAG 995
+L +S S G GG G +S+ + R E+ +S+S+ +
Sbjct: 1223 GTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQSQVN 1262
Query: 996 TTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1055
F + + + GSP+ + S T K V + G+
Sbjct: 1263 GFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1320
Query: 1056 TVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQA 1115
+ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1321 S---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFSSSP 1360
Query: 1116 TQEQDFYTVELERGAKGFGFSL-----RGGREYNM---DLYVLRLAEDGPAERCGKMRIG 1167
+ D + VEL + G S+ +GG ++ +YV + G AE G++ G
Sbjct: 1361 PKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKG 1420
Query: 1168 DEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPAT 1222
D +L +NG + + H +A+E ++N G+ V L L++G P+S H P T
Sbjct: 1421 DRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQ------SPTSKEHVPVT 1469
Score = 75.1 bits (183), Expect = 5e-13
Identities = 87/364 (23%), Positives = 154/364 (42%), Gaps = 47/364 (12%)
Query: 923 SLTEEKRTP-QGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 981
S +++ +TP Q S +S+NT + + T G ++VE+ + +N
Sbjct: 1329 SSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI---------FEVELAKNDNS-L 1378
Query: 982 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1041
G + + T+ + + + +I A+ G++ GDR+LAVNG S+
Sbjct: 1379 GISVTVLFDKGGVNTSVRHGGIY----VKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGA 1434
Query: 1042 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQ-QGTQETRNTT 1100
+H V ++ G V L + ++ + T + T + +Q QG ++ + TT
Sbjct: 1435 THKQAVETLRNTGQVVHLLL---EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTT 1491
Query: 1101 KPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--------LYVLRL 1152
+ K S E++ + V+L + + G GFS RE N+ + V +L
Sbjct: 1492 QVKDYS--------FVTEENTFEVKLFKNSSGLGFSF--SREDNLIPEQINASIVRVKKL 1541
Query: 1153 AEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR-GDGSVPEY 1211
PA GK+ +GD IL++NG + K + I ++ V L L R G +PE
Sbjct: 1542 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEI 1601
Query: 1212 DPS--SDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGS 1269
D + + PA Q +P + D Q +E S D ++ S +K+ + P
Sbjct: 1602 DTALLTPLQSPA---QVLP--NSSKDSSQPSCVEQSTSSDENEMSDKSKKQ--CKSPSRR 1654
Query: 1270 REYS 1273
YS
Sbjct: 1655 DSYS 1658
Score = 68.6 bits (166), Expect = 4e-11
Identities = 106/442 (23%), Positives = 172/442 (38%), Gaps = 115/442 (26%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1508 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1567
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1568 KGLSQQEVISALRGT--APEVFLLLCR--PPPGVLPEIDTALLTPLQ--SPAQVLPNSSK 1621
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1622 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1681
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1682 SALH--------------------QTLSNMVS---------------------QAQSHH- 1699
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1700 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1728
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKI-----------WAQSRSMYENRLPDYQ 810
+ + + P+ P ++ P Q++S+ D + I W ++ EN L D++
Sbjct: 1729 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1787
Query: 811 ---EQDIFLWRKETG-FGFRILGGNEPGEPIYIG---HIVPLGAADTDGRLRSGDELICV 863
E I L + E G GF + GN+ IG H V A +DGRL+ GD LI V
Sbjct: 1788 LEVELLITLIKSEKGSLGFTVTKGNQR-----IGCYVHDVIQDPAKSDGRLKPGDRLIKV 1842
Query: 864 DGTPVIGKSHQLVVQLMQQAAK 885
+ T V +H V L++ A+K
Sbjct: 1843 NDTDVTNMTHTDAVNLLRAASK 1864
Score = 67.4 bits (163), Expect = 1e-10
Identities = 69/295 (23%), Positives = 121/295 (41%), Gaps = 44/295 (14%)
Query: 837 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 896
IY+ ++P GAA++DGR+ GD ++ V+G + G +H+ V+ ++ + H+ L
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL----- 1454
Query: 897 VVFAVPKTENEVPSPASSHHSSNQP-ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGG 955
+ SP S H P +L+++ QG + T
Sbjct: 1455 ---------EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKD---------- 1495
Query: 956 GGGSGVVSTVVQPYDVEIRRGEN-EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIE 1014
S V + E++ +N G GF S SR + A ++ ++
Sbjct: 1496 ------YSFVTEENTFEVKLFKNSSGLGF----SFSRED--NLIPEQINASIVRVKKLFP 1543
Query: 1015 GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL---RIIPGD-ESSNA 1070
G PA GK+ VGD IL VNG S+ S ++++ ++ V L R PG +
Sbjct: 1544 GQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1603
Query: 1071 TLLTNAEKIATI--TTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1123
LLT + A + ++ SQ E ++ + S K ++ +D Y+
Sbjct: 1604 ALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYS 1658
Score = 49.7 bits (117), Expect = 2e-05
Identities = 28/108 (25%), Positives = 59/108 (54%), Gaps = 5/108 (4%)
Query: 1115 ATQEQDFYTVELERGAK-GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEI 1170
++ E++ V L++ AK G GF + GG + ++ +++ +A GPA+ G ++ GD +
Sbjct: 1085 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1144
Query: 1171 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRH 1218
+ +N + + + H AIE+++N V L + + + + PS+ H
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKV-PSTPVH 1191
Score = 47.8 bits (112), Expect = 8e-05
Identities = 26/73 (35%), Positives = 44/73 (60%), Gaps = 4/73 (5%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 531 THAQVVKIFQSIP 543
+H ++I Q+ P
Sbjct: 1156 SHHAAIEILQNAP 1168
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1017 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1826 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1870
Score = 45.4 bits (106), Expect = 4e-04
Identities = 85/428 (19%), Positives = 151/428 (35%), Gaps = 83/428 (19%)
Query: 564 DPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHG 623
D N S I D G D SS+ + P + + N+S+
Sbjct: 1298 DSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQDHQT-------PKQESSSSVNTSNK 1350
Query: 624 YPNDTVSLASSIATQPELITVHIVKGP--MGFGFTIADSPGG-------GGQRVKQIVDS 674
T S SS ++ V + K +G T+ GG GG VK ++
Sbjct: 1351 MNFKTFS--SSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQ 1408
Query: 675 PRCRG---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSP 731
+ +GD ++ VN +++ TH Q V+ L G V LL+++G P K+
Sbjct: 1409 GAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQSPTSKEHV 1466
Query: 732 KSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDP 791
P QN A+ Q P++ + Q K
Sbjct: 1467 PVTPQCTLSDQN-----------------------------AQGQGPEKVKKTTQVKDYS 1497
Query: 792 FKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGF------RILGGNEPGEPIYIGHIVPL 845
F + + ++ L++ +G GF ++ + + + P
Sbjct: 1498 F-------------VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPG 1544
Query: 846 GAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTE 905
A G++ GD ++ V+G + G S Q V+ ++ A + V L + R +P+ +
Sbjct: 1545 QPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPE--VFLLLCRPPPGVLPEID 1602
Query: 906 NEVPSP--------ASSHHSSNQPASLTEEKRTPQG--SQNSLNTVSSGSGSTSGIGSGG 955
+ +P +S S+QP+ + + + + S S S S S S G
Sbjct: 1603 TALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSG 1662
Query: 956 GGGSGVVS 963
G +V+
Sbjct: 1663 SGEDDLVT 1670
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1714 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1764
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1765 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1814
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1815 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1870
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1871 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1922
Query: 613 PADVASN 619
A + N
Sbjct: 1923 VAAIEGN 1929
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
V +++ G GF I+ G G + + I + G PAD G LK GDR+
Sbjct: 1094 VNLKKDAKYGLGFQIIG-------GEKMGRLDLGI--FISSVAPGGPADLDGCLKPGDRL 1144
Query: 1031 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061
++VN S+ SH + +++ A VTL I
Sbjct: 1145 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1175
Score = 42.4 bits (98), Expect = 0.003
Identities = 23/80 (28%), Positives = 47/80 (58%), Gaps = 4/80 (5%)
Query: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1797 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1852
Query: 1184 SRAIELIKNGGRRVRLFLKR 1203
+ A+ L++ + VRL + R
Sbjct: 1853 TDAVNLLRAASKTVRLVIGR 1872
Score = 40.8 bits (94), Expect = 0.010
Identities = 69/298 (23%), Positives = 112/298 (37%), Gaps = 77/298 (25%)
Query: 496 LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRG 555
+ +K+++ G A DG++ GD +++VN + G TH Q V+ ++ G V L L +G
Sbjct: 1400 IYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKG 1457
Query: 556 YPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPAD 615
P VT L + G E K K +KD
Sbjct: 1458 Q----SPTSKEHVPVTPQCTLSDQNAQGQGPE----------KVKKTTQVKD-------- 1495
Query: 616 VASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRV 668
S T+ V + K G GF+ I + RV
Sbjct: 1496 -----------------YSFVTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRV 1538
Query: 669 KQIV---DSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR-- 721
K++ + + GD+I++VN +++ L+ +V+ L +G+ EV LL+ R
Sbjct: 1539 KKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPP 1594
Query: 722 -GGLP-------VPKKSP----------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
G LP P +SP SQP + S +S ++ +S SPS
Sbjct: 1595 PGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1652
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
Length = 767
Score = 89.4 bits (220), Expect = 2e-17
Identities = 103/410 (25%), Positives = 167/410 (40%), Gaps = 99/410 (24%)
Query: 808 DYQEQDIFLWRKETGFGFRILGGNE-----PGEPIYIGHIVPLGAADTDGRLRSGDELIC 862
+ + ++I L R +G GF I GG + I+I I+P GAA DGRLR D ++
Sbjct: 103 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 162
Query: 863 VDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPA 922
V+ V +H V+ +++A V L V R+ PA
Sbjct: 163 VNEVDVREVTHSAAVEALKEAG--SIVRLYVMRR----------------------KPPA 198
Query: 923 SLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFG 982
E + +G + G+G GG G + G+N +
Sbjct: 199 EKVMEIKLIKGPK--------------GLGFSIAGGVG----------NQHIPGDNSIYV 234
Query: 983 FVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKS 1042
I+ E G HK GR+ ++GD+ILAVN + +
Sbjct: 235 TKII------EGGAA---------HKDGRL------------QIGDKILAVNSVGLEDVM 267
Query: 1043 HSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT---------PSQQGT 1093
H D V +K + V L++ + SNA L+++ ITT+++ S GT
Sbjct: 268 HEDAVAALKNTYDVVYLKVA---KPSNA-YLSDSYAPPDITTSYSQHLDNEISHSSYLGT 323
Query: 1094 QETRNTTKPKQESQFEFKAPQATQEQDF----YTVELERGAKGFGFSLRGGREYNMDLYV 1149
T P ++ A E+D + + RG+ G GF++ GG E +++
Sbjct: 324 DYPTAMT-PTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG-EDGEGIFI 381
Query: 1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
+ GPA+ G++R GD+IL +NG +N H +A +KN G+ V +
Sbjct: 382 SFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 431
Score = 73.2 bits (178), Expect = 2e-12
Identities = 80/318 (25%), Positives = 122/318 (38%), Gaps = 82/318 (25%)
Query: 970 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
++ + RG N G GF I P G I +II G A + G+L+V D
Sbjct: 108 EITLERG-NSGLGFSIAGGTDNPHIGDDPSIF-------ITKIIPGGAAAQDGRLRVNDS 159
Query: 1030 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
IL VN + +HS V +KEAG+ V L ++
Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM--------------------------- 192
Query: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-----N 1144
KP E E K L +G KG GFS+ GG +
Sbjct: 193 ---------RRKPPAEKVMEIK--------------LIKGPKGLGFSIAGGVGNQHIPGD 229
Query: 1145 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1204
+YV ++ E G A + G+++IGD+IL +N +++ H A+ +KN V L + +
Sbjct: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK- 288
Query: 1205 DGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRR-----QHPS-LESSYPPDLHKSSPHGE 1258
P SD + P P++ + H S L + YP + +SP
Sbjct: 289 ----PSNAYLSDSYAP-------PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRY 337
Query: 1259 KRAHARDPKGSREYSRQP 1276
A+D G + R+P
Sbjct: 338 SPV-AKDLLGEEDIPREP 354
Score = 68.2 bits (165), Expect = 6e-11
Identities = 71/266 (26%), Positives = 113/266 (42%), Gaps = 44/266 (16%)
Query: 807 PDYQEQDIFLWRKETGFGFRILGG----NEPGE-PIYIGHIVPLGAADTDGRLRSGDELI 861
P + +I L + G GF I GG + PG+ IY+ I+ GAA DGRL+ GD+++
Sbjct: 197 PAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 256
Query: 862 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS-SNQ 920
V+ + H+ V ++ VV+ +V P++++ S S
Sbjct: 257 AVNSVGLEDVMHEDAVAALKNTYD-----------VVYL------KVAKPSNAYLSDSYA 299
Query: 921 PASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV-------QPYDVEI 973
P +T ++ S ++ T+ + S V ++ +P + I
Sbjct: 300 PPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVI 359
Query: 974 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1033
RG G GF IV +F I+ G PAD G+L+ GD+IL+V
Sbjct: 360 HRGST-GLGFNIVGGEDGEGIFISF-------------ILAGGPADLSGELRKGDQILSV 405
Query: 1034 NGCSITNKSHSDIVNLIKEAGNTVTL 1059
NG + N SH +K AG TVT+
Sbjct: 406 NGVDLRNASHEQAAIALKNAGQTVTI 431
Score = 65.5 bits (158), Expect = 4e-10
Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 5/123 (4%)
Query: 1086 HTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-- 1143
H P+Q + T + +E + E ++ + LERG G GFS+ GG +
Sbjct: 71 HLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPH 130
Query: 1144 ---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1200
+ +++ ++ G A + G++R+ D IL +N + + HS A+E +K G VRL+
Sbjct: 131 IGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLY 190
Query: 1201 LKR 1203
+ R
Sbjct: 191 VMR 193
Score = 65.1 bits (157), Expect = 5e-10
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 38/256 (14%)
Query: 640 ELITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVN 690
+++ + ++KGP G GF+IA PG V +I++ L+ GD I+ VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 691 KKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVS 750
++ + H V L +V L ++P S + + ++
Sbjct: 260 SVGLEDVMHEDAVAALKNT---YDVVYL------------KVAKPSNAYLSDSYAPPDIT 304
Query: 751 SHRSLHTASP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDY 809
+ S H + SHS+ + ++P A + S K + E +P
Sbjct: 305 TSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKD-----------LLGEEDIPR- 352
Query: 810 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
+ + I + R TG GF I+GG E GE I+I I+ G AD G LR GD+++ V+G +
Sbjct: 353 EPRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 411
Query: 870 GKSHQLVVQLMQQAAK 885
SH+ ++ A +
Sbjct: 412 NASHEQAAIALKNAGQ 427
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/262 (24%), Positives = 102/262 (38%), Gaps = 37/262 (14%)
Query: 469 KFIHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
K + KL K +G GF++ GG D + + ++ G A DG+++ GD I++VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 524 DTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIV 583
+ H V ++ V L++ + N L S A D I
Sbjct: 260 SVGLEDVMHEDAVAALKN--TYDVVYLKVAK---------PSNAYLSDSYAPPD---ITT 305
Query: 584 NGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSL--ASSIATQPEL 641
+ + D+ SHSS G P + S Y L I +P
Sbjct: 306 SYSQHLDNEISHSSYLG---------TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR 356
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLKEGDLIVEVNKKNVQALT 698
I +H +G G GF I G G + I+ + L++GD I+ VN +++ +
Sbjct: 357 IVIH--RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 414
Query: 699 HNQVVDMLVECPKGSEVTLLVQ 720
H Q L G VT++ Q
Sbjct: 415 HEQAAIALKNA--GQTVTIIAQ 434
Score = 45.1 bits (105), Expect = 5e-04
Identities = 40/151 (26%), Positives = 69/151 (45%), Gaps = 11/151 (7%)
Query: 413 QQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTR-NPSELKGKFI 471
+ Q+ + Q + +HS P +PN S P L+ + + N +E + ++
Sbjct: 51 ESQKYRYQDEDTPPLEHS---PAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYE 107
Query: 472 HTKLRKSSRGFGFTVVGG-DEP----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
L + + G GF++ GG D P D + I ++ G AA DG++ D I+ VN+
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
Query: 527 VLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557
V TH+ V+ + G+ V L + R P
Sbjct: 168 VREVTHSAAVEALKE--AGSIVRLYVMRRKP 196
Score = 40.8 bits (94), Expect = 0.010
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR RE E+ G DY+F++ +E ++ + Q+ +E G Y + YGT
Sbjct: 606 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 654
Score = 30.8 bits (68), Expect = 10.0
Identities = 30/99 (30%), Positives = 42/99 (42%), Gaps = 21/99 (21%)
Query: 644 VHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRC--------------RGLKEGDLIVEV 689
+ + +G G GF+IA GG I D P L+ D I+ V
Sbjct: 109 ITLERGNSGLGFSIA-----GGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFV 163
Query: 690 NKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPK 728
N+ +V+ +TH+ V+ L E GS V L V R P K
Sbjct: 164 NEVDVREVTHSAAVEALKEA--GSIVRLYVMRRKPPAEK 200
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 89.4 bits (220), Expect = 2e-17
Identities = 103/410 (25%), Positives = 167/410 (40%), Gaps = 99/410 (24%)
Query: 808 DYQEQDIFLWRKETGFGFRILGGNE-----PGEPIYIGHIVPLGAADTDGRLRSGDELIC 862
+ + ++I L R +G GF I GG + I+I I+P GAA DGRLR D ++
Sbjct: 57 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
Query: 863 VDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPA 922
V+ V +H V+ +++A V L V R+ PA
Sbjct: 117 VNEVDVREVTHSAAVEALKEAG--SIVRLYVMRR----------------------KPPA 152
Query: 923 SLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFG 982
E + +G + G+G GG G + G+N +
Sbjct: 153 EKVMEIKLIKGPK--------------GLGFSIAGGVG----------NQHIPGDNSIYV 188
Query: 983 FVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKS 1042
I+ E G HK GR+ ++GD+ILAVN + +
Sbjct: 189 TKII------EGGAA---------HKDGRL------------QIGDKILAVNSVGLEDVM 221
Query: 1043 HSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT---------PSQQGT 1093
H D V +K + V L++ + SNA L+++ ITT+++ S GT
Sbjct: 222 HEDAVAALKNTYDVVYLKVA---KPSNA-YLSDSYAPPDITTSYSQHLDNEISHSSYLGT 277
Query: 1094 QETRNTTKPKQESQFEFKAPQATQEQDF----YTVELERGAKGFGFSLRGGREYNMDLYV 1149
T P ++ A E+D + + RG+ G GF++ GG E +++
Sbjct: 278 DYPTAMT-PTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGG-EDGEGIFI 335
Query: 1150 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
+ GPA+ G++R GD+IL +NG +N H +A +KN G+ V +
Sbjct: 336 SFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTI 385
Score = 73.2 bits (178), Expect = 2e-12
Identities = 80/318 (25%), Positives = 122/318 (38%), Gaps = 82/318 (25%)
Query: 970 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
++ + RG N G GF I P G I +II G A + G+L+V D
Sbjct: 62 EITLERG-NSGLGFSIAGGTDNPHIGDDPSIF-------ITKIIPGGAAAQDGRLRVNDS 113
Query: 1030 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
IL VN + +HS V +KEAG+ V L ++
Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM--------------------------- 146
Query: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-----N 1144
KP E E K L +G KG GFS+ GG +
Sbjct: 147 ---------RRKPPAEKVMEIK--------------LIKGPKGLGFSIAGGVGNQHIPGD 183
Query: 1145 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1204
+YV ++ E G A + G+++IGD+IL +N +++ H A+ +KN V L + +
Sbjct: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAK- 242
Query: 1205 DGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRR-----QHPS-LESSYPPDLHKSSPHGE 1258
P SD + P P++ + H S L + YP + +SP
Sbjct: 243 ----PSNAYLSDSYAP-------PDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRY 291
Query: 1259 KRAHARDPKGSREYSRQP 1276
A+D G + R+P
Sbjct: 292 SPV-AKDLLGEEDIPREP 308
Score = 68.2 bits (165), Expect = 6e-11
Identities = 71/266 (26%), Positives = 113/266 (42%), Gaps = 44/266 (16%)
Query: 807 PDYQEQDIFLWRKETGFGFRILGG----NEPGE-PIYIGHIVPLGAADTDGRLRSGDELI 861
P + +I L + G GF I GG + PG+ IY+ I+ GAA DGRL+ GD+++
Sbjct: 151 PAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKIL 210
Query: 862 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHS-SNQ 920
V+ + H+ V ++ VV+ +V P++++ S S
Sbjct: 211 AVNSVGLEDVMHEDAVAALKNTYD-----------VVYL------KVAKPSNAYLSDSYA 253
Query: 921 PASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV-------QPYDVEI 973
P +T ++ S ++ T+ + S V ++ +P + I
Sbjct: 254 PPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVI 313
Query: 974 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1033
RG G GF IV +F I+ G PAD G+L+ GD+IL+V
Sbjct: 314 HRGST-GLGFNIVGGEDGEGIFISF-------------ILAGGPADLSGELRKGDQILSV 359
Query: 1034 NGCSITNKSHSDIVNLIKEAGNTVTL 1059
NG + N SH +K AG TVT+
Sbjct: 360 NGVDLRNASHEQAAIALKNAGQTVTI 385
Score = 65.1 bits (157), Expect = 5e-10
Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 38/256 (14%)
Query: 640 ELITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVN 690
+++ + ++KGP G GF+IA PG V +I++ L+ GD I+ VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 691 KKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVS 750
++ + H V L +V L ++P S + + ++
Sbjct: 214 SVGLEDVMHEDAVAALKNT---YDVVYL------------KVAKPSNAYLSDSYAPPDIT 258
Query: 751 SHRSLHTASP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDY 809
+ S H + SHS+ + ++P A + S K + E +P
Sbjct: 259 TSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKD-----------LLGEEDIPR- 306
Query: 810 QEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVI 869
+ + I + R TG GF I+GG E GE I+I I+ G AD G LR GD+++ V+G +
Sbjct: 307 EPRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLR 365
Query: 870 GKSHQLVVQLMQQAAK 885
SH+ ++ A +
Sbjct: 366 NASHEQAAIALKNAGQ 381
Score = 60.5 bits (145), Expect = 1e-08
Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 5/91 (5%)
Query: 1118 EQDFYTVELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDGPAERCGKMRIGDEILE 1172
E ++ + LERG G GFS+ GG + + +++ ++ G A + G++R+ D IL
Sbjct: 57 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
Query: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFLKR 1203
+N + + HS A+E +K G VRL++ R
Sbjct: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/262 (24%), Positives = 102/262 (38%), Gaps = 37/262 (14%)
Query: 469 KFIHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
K + KL K +G GF++ GG D + + ++ G A DG+++ GD I++VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 524 DTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIV 583
+ H V ++ V L++ + N L S A D I
Sbjct: 214 SVGLEDVMHEDAVAALKN--TYDVVYLKVAK---------PSNAYLSDSYAPPD---ITT 259
Query: 584 NGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSL--ASSIATQPEL 641
+ + D+ SHSS G P + S Y L I +P
Sbjct: 260 SYSQHLDNEISHSSYLG---------TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR 310
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLKEGDLIVEVNKKNVQALT 698
I +H +G G GF I G G + I+ + L++GD I+ VN +++ +
Sbjct: 311 IVIH--RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368
Query: 699 HNQVVDMLVECPKGSEVTLLVQ 720
H Q L G VT++ Q
Sbjct: 369 HEQAAIALKNA--GQTVTIIAQ 388
Score = 43.9 bits (102), Expect = 0.001
Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 9/129 (6%)
Query: 434 PPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGG-DEP 492
P +PN S P L+ + E++ + I L + + G GF++ GG D P
Sbjct: 26 PAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEI--TLERGNSGLGFSIAGGTDNP 83
Query: 493 ----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASV 548
D + I ++ G AA DG++ D I+ VN+ V TH+ V+ + G+ V
Sbjct: 84 HIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKE--AGSIV 141
Query: 549 DLELCRGYP 557
L + R P
Sbjct: 142 RLYVMRRKP 150
Score = 40.8 bits (94), Expect = 0.010
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR RE E+ G DY+F++ +E ++ + Q+ +E G Y + YGT
Sbjct: 560 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 608
Score = 31.2 bits (69), Expect = 7.7
Identities = 35/120 (29%), Positives = 48/120 (40%), Gaps = 28/120 (23%)
Query: 623 GYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRC----- 677
GY N T + E + + +G G GF+IA GG I D P
Sbjct: 49 GYVNGTEG-------EMEYEEITLERGNSGLGFSIA-----GGTDNPHIGDDPSIFITKI 96
Query: 678 ---------RGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPK 728
L+ D I+ VN+ +V+ +TH+ V+ L E GS V L V R P K
Sbjct: 97 IPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEA--GSIVRLYVMRRKPPAEK 154
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 89.4 bits (220), Expect = 2e-17
Identities = 112/451 (24%), Positives = 183/451 (40%), Gaps = 77/451 (17%)
Query: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGG--GQRVKQIVDSPRCRG---LKEGDLIVE 688
S+ +L+ V GP+G + GG G VK++ + +E D IV
Sbjct: 267 SLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
Query: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--------- 739
+N +++ Q M + + T ++ +P K Q + +
Sbjct: 327 INDGDLRNRRFEQAQHMFRQAMR----TPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRF 382
Query: 740 --DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD-----PF 792
DSQ SV+S LHT + PE + ++ P SG K P P
Sbjct: 383 SPDSQYIDNRSVNS-AGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSG-KPPSAPASAPQ 440
Query: 793 KIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRI------LGGNEPGEPIYIGHIVPLG 846
+++ + S N + +I L + G GF I +GG+ P IY+ +I+P G
Sbjct: 441 NVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRG 497
Query: 847 AADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN 906
AA DGRL++GD LI V+G ++GKS + VV L++ +G V+L V R+ P+ N
Sbjct: 498 AAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELN 557
Query: 907 EVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN-TVSSGSGSTSGIGSGGGGGSGVVSTV 965
PS + A + TP G++ L V ++G+G G
Sbjct: 558 AEPSQMQIPKETK--AEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGN------- 608
Query: 966 VQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLK 1025
R EN + V S II G A + G+L+
Sbjct: 609 --------RSKENHADLGIFVKS-----------------------IINGGAASKDGRLR 637
Query: 1026 VGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1056
V D+++AVNG S+ K++ D + ++ + +T
Sbjct: 638 VNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
Score = 76.6 bits (187), Expect = 2e-13
Identities = 75/291 (25%), Positives = 133/291 (45%), Gaps = 59/291 (20%)
Query: 911 PASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYD 970
P S+H S P++ QN +T S +T IG + +
Sbjct: 422 PHSAHPSGKPPSA------PASAPQNVFSTTVSSGYNTKKIG--------------KRLN 461
Query: 971 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030
+++++G EG GF I S T G + P + I+ A + G+LK GDR+
Sbjct: 462 IQLKKG-TEGLGFSITSR------DVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRL 511
Query: 1031 LAVNGCSITNKSHSDIVNLIK--EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1088
+ VNG + KS ++V+L++ + TV+L + +++ + L NAE P
Sbjct: 512 IEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL-NAE----------P 560
Query: 1089 SQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL---ERGAKGFGFSLRGGR--- 1141
SQ Q +ET K E + P T+E F T E+ + G+ G G S++G R
Sbjct: 561 SQMQIPKET------KAEDEDIVLTPDGTRE--FLTFEVPLNDSGSAGLGVSVKGNRSKE 612
Query: 1142 -EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1191
++ ++V + G A + G++R+ D+++ +NGE+ + A+E ++
Sbjct: 613 NHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
Score = 61.6 bits (148), Expect = 5e-09
Identities = 124/549 (22%), Positives = 197/549 (35%), Gaps = 139/549 (25%)
Query: 417 QQQQQTEEWTEDHSALVPPV---------IPNHPPSNPEPAREVPLQGKPFFTRNPSELK 467
++Q+Q E+ TE+ ++ V PV IPN + EVP G P
Sbjct: 234 EKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPL--------- 284
Query: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
G + + R G L +K L G A + D IV +ND +
Sbjct: 285 GIHVVPFSARGGRTLG------------LLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
Query: 528 LGHTHAQVVKIFQS-----------IPIGASVDLELCRG------YPLPFDPDDP--NTS 568
Q +F+ +P E Y F PD +
Sbjct: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNR 392
Query: 569 LVTSVAI--LDKEPIIVNGQETYDSPAS--HSSK-TGKVNGMKDARPSSPADVASNSSHG 623
V S + + + P + + E DS + HS+ +GK PS+PA N
Sbjct: 393 SVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKP-------PSAPASAPQNVF-- 443
Query: 624 YPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG---- 679
+ TVS + + + + + KG G GF+I G V + RG
Sbjct: 444 --STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQ 501
Query: 680 ---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
LK GD ++EVN ++ + +VV +L V+LLV R
Sbjct: 502 DGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR--------------- 546
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK---KPDPFK 793
Q R L+ P++ Q P +T + + PD +
Sbjct: 547 ---------QEDAFHPRELNAE-------------PSQMQIPKETKAEDEDIVLTPDGTR 584
Query: 794 IWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGG----NEPGEPIYIGHIVPLGAAD 849
+ +E L D G G + G N I++ I+ GAA
Sbjct: 585 EFLT----FEVPLND---------SGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAAS 631
Query: 850 TDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAA-----KQGHVNLTVRRKVVFAVPKT 904
DGRLR D+LI V+G ++GK++Q ++ ++++ K+G + L V R++
Sbjct: 632 KDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRI-----SK 686
Query: 905 ENEVPSPAS 913
NE+ SP S
Sbjct: 687 CNELKSPGS 695
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 11/148 (7%)
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPN-HPPSNPEPAREVPLQGKPFFTRNPSELKGKFIH 472
Q+ + E + HS L P+ PPS P A + N ++ GK ++
Sbjct: 403 QRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-GKRLN 461
Query: 473 TKLRKSSRGFGFTV------VGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
+L+K + G GF++ +GG P + +K+++ G A DG+++ GD ++ VN
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
Query: 527 VLGHTHAQVVKIFQSIPIGASVDLELCR 554
++G + +VV + +S + +V L + R
Sbjct: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 39.3 bits (90), Expect = 0.028
Identities = 39/234 (16%), Positives = 87/234 (37%), Gaps = 53/234 (22%)
Query: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLRIIPGDE 1066
+ R+ +G A+ + D I+ +N + N+ ++ ++A T + ++P
Sbjct: 303 VKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAAN 362
Query: 1067 SSNATLLTNAEKIATITTTHTPSQQ-------------GTQETRNTTKPKQESQFEFKAP 1113
L+ +EK ++ +P Q Q P ++ + P
Sbjct: 363 KEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLP 422
Query: 1114 Q------------ATQEQDFYT-----------------VELERGAKGFGFSLR------ 1138
A+ Q+ ++ ++L++G +G GFS+
Sbjct: 423 HSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTI 482
Query: 1139 GGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
GG + +YV + G A + G+++ GD ++E+NG + L+++
Sbjct: 483 GG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
Score = 37.0 bits (84), Expect = 0.14
Identities = 35/154 (22%), Positives = 63/154 (40%), Gaps = 21/154 (13%)
Query: 479 SRGFGFTVVGG----DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
S G G +V G + D + +KS++ G A+ DG++ D +++VN +LG T+
Sbjct: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
Query: 535 VVKIFQ-----------SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPII- 582
++ + I + + + C P P P + T A+ D+E I
Sbjct: 658 AMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIET--ALDDRERRIS 715
Query: 583 ---VNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
+G E D S ++ ++ G SP
Sbjct: 716 HSLYSGIEGLDESPSRNAALSRIMGESGKYQLSP 749
Score = 31.6 bits (70), Expect = 5.9
Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 15/76 (19%)
Query: 400 LEQQQQQQQQQQQQQQQQQQQQTEEWTEDHS--------ALVPPVIP---NHPPSNPEPA 448
LE Q+ +Q+Q++++QQ ++Q E ++ + PP P + PPS + A
Sbjct: 1281 LETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVA 1340
Query: 449 R----EVPLQGKPFFT 460
R + P +G+PF++
Sbjct: 1341 RLNRLQTPEKGRPFYS 1356
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
Query: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
Query: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Query: 463 PSELKGKFIHT--KLRKSSRGF 482
++LK + +H +L+ RGF
Sbjct: 171 VNKLKREMVHLQHELQFKERGF 192
Score = 38.9 bits (89), Expect = 0.037
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
Query: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
Query: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Query: 463 PSELKGKFIHT--KLRKSSRGF 482
++LK + +H +L+ RGF
Sbjct: 171 VNKLKREMVHLQHELQFKERGF 192
Score = 38.9 bits (89), Expect = 0.037
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
Query: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
Query: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Query: 463 PSELKGKFIHT--KLRKSSRGF 482
++LK + +H +L+ RGF
Sbjct: 171 VNKLKREMVHLQHELQFKERGF 192
Score = 38.9 bits (89), Expect = 0.037
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 87.4 bits (215), Expect = 9e-17
Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 21/135 (15%)
Query: 291 LPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLE--ECEDDE 348
+P A PLP WE A +G+V++IDHNT+ TSW+DPR ++ KPL +C D
Sbjct: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR--DRLTKPLSFADCVGD- 57
Query: 349 GVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQ 408
ELP GWE DP G+YY+DHIN+ TQ E+P RK+ +Q++ +
Sbjct: 58 -----------ELPWGWEAGFDPQIGVYYIDHINKTTQIEDP-----RKQWRGEQEKMLK 101
Query: 409 QQQQQQQQQQQQQTE 423
Q + Q E
Sbjct: 102 DYLSVAQDALRTQKE 116
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 85.9 bits (211), Expect = 3e-16
Identities = 67/228 (29%), Positives = 93/228 (40%), Gaps = 38/228 (16%)
Query: 215 KQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADS--GEQEEHTLQETALPPVN 272
+QS R++ ++N+G N +D P + S G + P N
Sbjct: 209 EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPN 268
Query: 273 SSIIAAPIT-----DPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTS 327
++ + AP T +PS Q LP +A+ LP WE NG VY++DHNTKTT+
Sbjct: 269 TTSLPAPATPAEGEEPSTSGTQQLPAAAQAP-DALPAGWEQRELPNGRVYYVDHNTKTTT 327
Query: 328 WLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQY 387
W E LP GWEK DP YYVDH R T +
Sbjct: 328 W-----------------------------ERPLPPGWEKRTDPRGRFYYVDHNTRTTTW 358
Query: 388 ENPVLEAKRK-KQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVP 434
+ P E R +Q + Q+ Q Q Q Q+ Q+ + DH L P
Sbjct: 359 QRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGP 406
Score = 63.9 bits (154), Expect = 1e-09
Identities = 35/94 (37%), Positives = 46/94 (48%), Gaps = 20/94 (21%)
Query: 297 DNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELD 356
D LGPLP WE +NG VY+++HNT+TT W DPR T+ +
Sbjct: 402 DPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPR-------------------TQGMI 441
Query: 357 SELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
E LP GWE Y+VDH R T +++P
Sbjct: 442 QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
Score = 48.5 bits (114), Expect = 5e-05
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 302 LPENWEMAYTENGEVYFIDHNTKTTSWLDPR 332
LP WEM YT G YF+DHNT+TT++ DPR
Sbjct: 446 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 476
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 85.1 bits (209), Expect = 4e-16
Identities = 69/234 (29%), Positives = 105/234 (44%), Gaps = 25/234 (10%)
Query: 1248 PDLHKSSPHGEKRAHARDPKGS--------REYSRQPNEHHTWNGTSRKPDSGACRPKDR 1299
P +S H + RD +GS R S PN+ + SR P+ R + R
Sbjct: 359 PSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRD-HSRSRSPNKARDRSRSR 417
Query: 1300 APEGRRDAQAERAA--AANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRER 1357
+P RD R+ A + + RSP K R+ +RS R + + + +R R R
Sbjct: 418 SPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSR 477
Query: 1358 SPTRRRD----GSPSRRRR-------SLERLLEQRRSPERRRGGSPERR-AKSTDRRRAR 1405
SP++ RD GSPS+ R S ER Q RS + R R +K RR++R
Sbjct: 478 SPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSR 537
Query: 1406 SPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKECSTD 1459
SP + R+RS + E+R HR+ + ++D R R P ++R R S++
Sbjct: 538 SPNKERDRSQSRSPSEER-EHRQSRSPSKERDR-RRWRSPSKERERRQSRSSSE 589
Score = 77.8 bits (190), Expect = 7e-14
Identities = 66/249 (26%), Positives = 103/249 (41%), Gaps = 10/249 (4%)
Query: 1214 SSDRHGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYS 1273
SS R G P + R + P+ + +S R+ +R P +R+ S
Sbjct: 381 SSPRKESGRSQSGSPNKQRDHSRSRSPN--KARDRSRSRSPYKARDRSRSRSPNKARDCS 438
Query: 1274 RQPNEHHTWNGT-SRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRR--SPEKRREGT 1330
R + + + + SR P+ + R+P RD R+ + + SP K R+
Sbjct: 439 RSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHR 498
Query: 1331 RSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGG 1390
RS + ER+ + + + RR RSP++ R SR ER Q RSP R
Sbjct: 499 RSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNK-ERDRSQSRSPSEEREH 557
Query: 1391 SPERR-AKSTDRRRARSPERRRERSLDKRNREDRASHRER---EEANLKQDAGRSSRHPP 1446
R +K DRRR RSP + RER + + E+R R R +++ + S
Sbjct: 558 RQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASSKEKAH 617
Query: 1447 EQRRRPYKE 1455
+ R P KE
Sbjct: 618 SRSRTPSKE 626
Score = 72.0 bits (175), Expect = 4e-12
Identities = 72/280 (25%), Positives = 117/280 (41%), Gaps = 48/280 (17%)
Query: 1208 VPEYDPSSDRHGPATGPQGVP--EVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARD 1265
V Y+ +S R P + Q R+G +R H + S S RA +R
Sbjct: 266 VKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSH-------SWKRNHSRARSRT 318
Query: 1266 PKG----------SREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAA 1315
KG SR +S+ +++ SR P G R P R R+++
Sbjct: 319 RKGILSQMGRHSQSRSHSKGKSQNQ-----SRTPRRGRSHNWSRNPSKERSHSHSRSSSK 373
Query: 1316 NGPKRRSPEKRREGTRSADNTLERREKHEKRR--DVSPERRRERSPTRRRDGSPSR---R 1370
R S R+E RS + ++ H + R + + +R R RSP + RD S SR +
Sbjct: 374 ERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNK 433
Query: 1371 RRSLERLLEQRRSPERRRGGSPERRA---------KSTDRRRARSPERRRER------SL 1415
R R ++ +R R SP + K+ DR R+RSP + R+ S
Sbjct: 434 ARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSK 493
Query: 1416 DKRNREDRASHRERE----EANLKQDAGRSSRHPPEQRRR 1451
++ +R R+ +ER+ ++ K+ R SR P ++R+R
Sbjct: 494 ERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQR 533
Score = 59.7 bits (143), Expect = 2e-08
Identities = 57/228 (25%), Positives = 96/228 (42%), Gaps = 19/228 (8%)
Query: 1235 DRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSR--QPNEHHTWNGTSRKPDSG 1292
DR + S + +S R+ +R P R++S+ P++ +
Sbjct: 448 DRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKER 507
Query: 1293 ACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPE 1352
CR + R+ RD + R+ + +R+S +E RS + +H + R S E
Sbjct: 508 QCR-QSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKE 566
Query: 1353 --RRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERR 1410
RRR RSP++ R+ S R S ER + RSP ++ G S R RA S E+
Sbjct: 567 RDRRRWRSPSKERERRQS-RSSSEERDHSRSRSPNKQSGYS---------RPRASSKEKA 616
Query: 1411 RERSLDKRNREDRASHREREEANLKQDAGRSS-RHPPEQRRRPYKECS 1457
RS R +H + ++ + D +S+ P+ +R P + S
Sbjct: 617 HSRS---RTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS 661
Score = 42.0 bits (97), Expect = 0.004
Identities = 54/221 (24%), Positives = 82/221 (37%), Gaps = 34/221 (15%)
Query: 1228 PEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHA-RDPKGSREYSRQPNEHHTWNGTS 1286
P + P P+ + P L + R+ P SR P+ + TS
Sbjct: 10 PSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTS 69
Query: 1287 RKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTL--ERREKHE 1344
K RAP R +++ + A P R S + R A + +RR H
Sbjct: 70 TK----------RAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHS 119
Query: 1345 KRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRA 1404
+ R +P RR RS R SPSR +P R R A+ R
Sbjct: 120 RGR--TPGRRGSRSSKR----SPSR-----------ASTPGRIR----THGARPGMASRV 158
Query: 1405 RSPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHP 1445
R+P +++ S K R S+RER ++ + + +S R P
Sbjct: 159 RTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPP 199
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 84.7 bits (208), Expect = 6e-16
Identities = 68/254 (26%), Positives = 102/254 (40%), Gaps = 27/254 (10%)
Query: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1068
I R+ E PA R G ++VGD++L VNG ++ H + V ++ AG V +R+
Sbjct: 760 ISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVW------ 812
Query: 1069 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELER 1128
+ E TIT +E R E P + + L R
Sbjct: 813 -RERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQR----HVACLAR 867
Query: 1129 GAKGFGFSLRGG------REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1182
+G GFS+ GG R + ++V R+AE G A R G +++GD +L ING +
Sbjct: 868 SERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 1183 HSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGP---------ATGPQGVPEVRAG 1233
H A+ L+ + L L+R G P P T GVP + +
Sbjct: 928 HDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSL 987
Query: 1234 PDRRQHPSLESSYP 1247
+LE YP
Sbjct: 988 APSLLAAALEGPYP 1001
Score = 82.4 bits (202), Expect = 3e-15
Identities = 109/500 (21%), Positives = 186/500 (37%), Gaps = 88/500 (17%)
Query: 730 SPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKP 789
+P++Q E ++ + S Q + A ++ + A AP S +
Sbjct: 654 APRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQA- 712
Query: 790 DPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEP------GEPIYIGHIV 843
+ + E + +E + + R+ G G I GG E I+I +
Sbjct: 713 --------NNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVS 764
Query: 844 PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV-----V 898
G A G +R GD+L+ V+G + G H V+ ++ A + + R V V
Sbjct: 765 EEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAV 823
Query: 899 FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGG 958
P + SP + L E P ++ V+ + S G+G GG
Sbjct: 824 TITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRH----VACLARSERGLGFSIAGG 879
Query: 959 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPA 1018
G PY R G+ F + RI EG A
Sbjct: 880 KGST-----PY----RAGDAGIF---------------------------VSRIAEGGAA 903
Query: 1019 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI-------IPGDESSNAT 1071
R G L+VGDR+L++NG +T H V+L+ A T+ L + +P +++
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
Query: 1072 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1131
T A +ITT TP G + + P +E + L R
Sbjct: 964 PPTAAVATTSITTA-TPGVPGLPSLAPSLLAA-----ALEGPYPVEE-----IRLPRAGG 1012
Query: 1132 GFGFSLRGGREYNM--------DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
G S+ GG +++ +++ ++ G A R G +R+GD IL +NG+ ++ H
Sbjct: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
Query: 1184 SRAIELIKNGGRRVRLFLKR 1203
A+ + + L ++R
Sbjct: 1072 QEAVSALLRPCLELSLLVRR 1091
Score = 80.5 bits (197), Expect = 1e-14
Identities = 184/847 (21%), Positives = 312/847 (36%), Gaps = 165/847 (19%)
Query: 638 QPELITVHIVKGPMGFGFTIADSPGGGG----------QRVKQIVDSPRCR-GLKEGDLI 686
+ E +T+ I++ G G +IA G RV + + P R G++ GD +
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSE--EGPAARAGVRVGDKL 780
Query: 687 VEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ 746
+EVN +Q H++ V+ L G+ V + V R + P+ + PL +D + +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA--GTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
Query: 747 HSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRL 806
R LP PP + P P +
Sbjct: 839 RRGGGLR-------------LPLLPP--------------ESPGPLR------------- 858
Query: 807 PDYQEQDIFLWRKETGFGFRILGGN-----EPGEP-IYIGHIVPLGAADTDGRLRSGDEL 860
Q L R E G GF I GG G+ I++ I GAA G L+ GD +
Sbjct: 859 ---QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRV 915
Query: 861 ICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQ 920
+ ++G V H V L+ A+ + L + R+ +P PSP HSS
Sbjct: 916 LSINGVDVTEARHDHAVSLLTAASPT--IALLLEREAGGPLP------PSPLP--HSSPP 965
Query: 921 PASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEG 980
A++ + S+ T + G + S + + + PY VE R G
Sbjct: 966 TAAV---------ATTSITTATPGVPGLPSLAP-----SLLAAALEGPYPVEEIRLPRAG 1011
Query: 981 --FGFVIVSSVSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCS 1037
G IV + FG V P I +++ A R G L+VGDRILAVNG
Sbjct: 1012 GPLGLSIVGGSDH--SSHPFG---VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065
Query: 1038 ITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR 1097
+ + +H + V+ + ++L + P+ G +E
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLV-----------------------RRDPAPPGLRELC 1102
Query: 1098 NTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGP 1157
P + + + GA+G + R + +++ +++ G
Sbjct: 1103 IQKAPGER----------------LGISIRGGARGHAGNPRDPTDEG--IFISKVSPTGA 1144
Query: 1158 AERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDR 1217
A R G++R+G +LE+N ++ + H A++L+++ G + + + G ++ S+D
Sbjct: 1145 AGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG------FEASTDA 1198
Query: 1218 HGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHAR----DPKGSREYS 1273
+ AG R SS +L P EK + P+ +
Sbjct: 1199 ALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAG 1258
Query: 1274 R--QPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQ-AERAAAANGPKRRSPEKRREGT 1330
R QP + + + P +G+ + R P G + AE + +G + SP E
Sbjct: 1259 RGLQPLK-LDYRALAAVPSAGSVQ---RVPSGAAGGKMAESPCSPSGQQPPSPPSPDE-- 1312
Query: 1331 RSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRR-RSLERLLE-QRRSPERRR 1388
A+ R PE + PT SP + R ++ E + R P+
Sbjct: 1313 LPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAE- 1371
Query: 1389 GGSPER--RAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHPP 1446
G P+R + D R+ + E R+ + KR + R + EA L D
Sbjct: 1372 -GPPKRVSLVGADDLRKMQEEEARKLQ--QKRAQMLREAAEAGAEARLALDGETLGEEEQ 1428
Query: 1447 EQRRRPY 1453
E + P+
Sbjct: 1429 EDEQPPW 1435
Score = 50.8 bits (120), Expect = 9e-06
Identities = 101/439 (23%), Positives = 160/439 (36%), Gaps = 64/439 (14%)
Query: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1068
I ++ A R G+L+VG R+L VN S+ +H + V L++ G+T+T+ + G E+S
Sbjct: 1136 ISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAS 1195
Query: 1069 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELER 1128
T+A + P G RN+ + E +E++ L
Sbjct: 1196 -----TDAALEVSPGVIANPFAAGIGH-RNSLESISSIDRELSPEGPGKEKELPGQTLHW 1249
Query: 1129 GAKGFGFSLRGGREYNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHS--R 1185
G + + RG + +D L + G +R G ++ E + S
Sbjct: 1250 GPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPS 1309
Query: 1186 AIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESS 1245
EL N + R F PE P+ P GP PE + +R+++ LE
Sbjct: 1310 PDELPANVKQAYRAFAAVPTSHPPEDAPAQP---PTPGPAASPEQLSFRERQKYFELEVR 1366
Query: 1246 YPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRR 1305
P + P A D + +E + + ++
Sbjct: 1367 VPQ--AEGPPKRVSLVGADDLRKMQEEEARKLQ-------------------------QK 1399
Query: 1306 DAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSP---ERRRERSPTRR 1362
AQ R AA G + R + E ++ E+ SP R+ SP
Sbjct: 1400 RAQMLREAAEAGAEARL-------ALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPL 1452
Query: 1363 RDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNRED 1422
G+P R ++ +RR ER R SPE A RA SP R +K
Sbjct: 1453 GGGAPVRTAKA------ERRHQERLRVQSPEPPAP----ERALSPAELRALEAEK----- 1497
Query: 1423 RASHREREEANLKQDAGRS 1441
RA R +L+QDA R+
Sbjct: 1498 RALWRAARMKSLEQDALRA 1516
Score = 48.1 bits (113), Expect = 6e-05
Identities = 64/271 (23%), Positives = 106/271 (39%), Gaps = 60/271 (22%)
Query: 475 LRKSSRGFGFTVVGGDEP------DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
L +S RG GF++ GG D + + + G A G ++ GD ++S+N V
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDP---DDPNTSLVTSVAILDKEPIIVNG 585
H V + + ++ LE G PLP P P T+ V + +I P
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATP----- 979
Query: 586 QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVH 645
G+ +P+ +A+ YP + + L +
Sbjct: 980 ------------------GVPGLPSLAPSLLAAALEGPYPVEEIRLPRA----------- 1010
Query: 646 IVKGPMGF----GFTIADSPGG---GGQRVKQIVDSPR----CRGLKEGDLIVEVNKKNV 694
GP+G G + P G G + +++ PR GL+ GD I+ VN ++V
Sbjct: 1011 --GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVL--PRGLAARSGLRVGDRILAVNGQDV 1066
Query: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLP 725
+ TH + V L+ E++LLV+R P
Sbjct: 1067 RDATHQEAVSALLR--PCLELSLLVRRDPAP 1095
Score = 38.9 bits (89), Expect = 0.037
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
D DE + I + G A DG++ G ++ VN +LG TH + V++ +S +G ++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS--VGDTLT 1185
Query: 550 LELCRGYPLPFD 561
+ +C G+ D
Sbjct: 1186 VLVCDGFEASTD 1197
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 84.7 bits (208), Expect = 6e-16
Identities = 68/254 (26%), Positives = 102/254 (40%), Gaps = 27/254 (10%)
Query: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1068
I R+ E PA R G ++VGD++L VNG ++ H + V ++ AG V +R+
Sbjct: 760 ISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVW------ 812
Query: 1069 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELER 1128
+ E TIT +E R E P + + L R
Sbjct: 813 -RERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQR----HVACLAR 867
Query: 1129 GAKGFGFSLRGG------REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1182
+G GFS+ GG R + ++V R+AE G A R G +++GD +L ING +
Sbjct: 868 SERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 1183 HSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGP---------ATGPQGVPEVRAG 1233
H A+ L+ + L L+R G P P T GVP + +
Sbjct: 928 HDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSL 987
Query: 1234 PDRRQHPSLESSYP 1247
+LE YP
Sbjct: 988 APSLLAAALEGPYP 1001
Score = 82.4 bits (202), Expect = 3e-15
Identities = 109/500 (21%), Positives = 186/500 (37%), Gaps = 88/500 (17%)
Query: 730 SPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKP 789
+P++Q E ++ + S Q + A ++ + A AP S +
Sbjct: 654 APRAQKEEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQA- 712
Query: 790 DPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEP------GEPIYIGHIV 843
+ + E + +E + + R+ G G I GG E I+I +
Sbjct: 713 --------NNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVS 764
Query: 844 PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV-----V 898
G A G +R GD+L+ V+G + G H V+ ++ A + + R V V
Sbjct: 765 EEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAV 823
Query: 899 FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGG 958
P + SP + L E P ++ V+ + S G+G GG
Sbjct: 824 TITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRH----VACLARSERGLGFSIAGG 879
Query: 959 SGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPA 1018
G PY R G+ F + RI EG A
Sbjct: 880 KGST-----PY----RAGDAGIF---------------------------VSRIAEGGAA 903
Query: 1019 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI-------IPGDESSNAT 1071
R G L+VGDR+L++NG +T H V+L+ A T+ L + +P +++
Sbjct: 904 HRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSS 963
Query: 1072 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1131
T A +ITT TP G + + P +E + L R
Sbjct: 964 PPTAAVATTSITTA-TPGVPGLPSLAPSLLAA-----ALEGPYPVEE-----IRLPRAGG 1012
Query: 1132 GFGFSLRGGREYNM--------DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183
G S+ GG +++ +++ ++ G A R G +R+GD IL +NG+ ++ H
Sbjct: 1013 PLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATH 1071
Query: 1184 SRAIELIKNGGRRVRLFLKR 1203
A+ + + L ++R
Sbjct: 1072 QEAVSALLRPCLELSLLVRR 1091
Score = 80.5 bits (197), Expect = 1e-14
Identities = 184/847 (21%), Positives = 312/847 (36%), Gaps = 165/847 (19%)
Query: 638 QPELITVHIVKGPMGFGFTIADSPGGGG----------QRVKQIVDSPRCR-GLKEGDLI 686
+ E +T+ I++ G G +IA G RV + + P R G++ GD +
Sbjct: 723 EEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSE--EGPAARAGVRVGDKL 780
Query: 687 VEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQ 746
+EVN +Q H++ V+ L G+ V + V R + P+ + PL +D + +
Sbjct: 781 LEVNGVALQGAEHHEAVEALRGA--GTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRE 838
Query: 747 HSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRL 806
R LP PP + P P +
Sbjct: 839 RRGGGLR-------------LPLLPP--------------ESPGPLR------------- 858
Query: 807 PDYQEQDIFLWRKETGFGFRILGGN-----EPGEP-IYIGHIVPLGAADTDGRLRSGDEL 860
Q L R E G GF I GG G+ I++ I GAA G L+ GD +
Sbjct: 859 ---QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRV 915
Query: 861 ICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQ 920
+ ++G V H V L+ A+ + L + R+ +P PSP HSS
Sbjct: 916 LSINGVDVTEARHDHAVSLLTAASPT--IALLLEREAGGPLP------PSPLP--HSSPP 965
Query: 921 PASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEG 980
A++ + S+ T + G + S + + + PY VE R G
Sbjct: 966 TAAV---------ATTSITTATPGVPGLPSLAP-----SLLAAALEGPYPVEEIRLPRAG 1011
Query: 981 --FGFVIVSSVSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCS 1037
G IV + FG V P I +++ A R G L+VGDRILAVNG
Sbjct: 1012 GPLGLSIVGGSDH--SSHPFG---VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQD 1065
Query: 1038 ITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR 1097
+ + +H + V+ + ++L + P+ G +E
Sbjct: 1066 VRDATHQEAVSALLRPCLELSLLV-----------------------RRDPAPPGLRELC 1102
Query: 1098 NTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGP 1157
P + + + GA+G + R + +++ +++ G
Sbjct: 1103 IQKAPGER----------------LGISIRGGARGHAGNPRDPTDEG--IFISKVSPTGA 1144
Query: 1158 AERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDR 1217
A R G++R+G +LE+N ++ + H A++L+++ G + + + G ++ S+D
Sbjct: 1145 AGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDG------FEASTDA 1198
Query: 1218 HGPATGPQGVPEVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHAR----DPKGSREYS 1273
+ AG R SS +L P EK + P+ +
Sbjct: 1199 ALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAG 1258
Query: 1274 R--QPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQ-AERAAAANGPKRRSPEKRREGT 1330
R QP + + + P +G+ + R P G + AE + +G + SP E
Sbjct: 1259 RGLQPLK-LDYRALAAVPSAGSVQ---RVPSGAAGGKMAESPCSPSGQQPPSPPSPDE-- 1312
Query: 1331 RSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRR-RSLERLLE-QRRSPERRR 1388
A+ R PE + PT SP + R ++ E + R P+
Sbjct: 1313 LPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAE- 1371
Query: 1389 GGSPER--RAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHPP 1446
G P+R + D R+ + E R+ + KR + R + EA L D
Sbjct: 1372 -GPPKRVSLVGADDLRKMQEEEARKLQ--QKRAQMLREAAEAGAEARLALDGETLGEEEQ 1428
Query: 1447 EQRRRPY 1453
E + P+
Sbjct: 1429 EDEQPPW 1435
Score = 50.8 bits (120), Expect = 9e-06
Identities = 101/439 (23%), Positives = 160/439 (36%), Gaps = 64/439 (14%)
Query: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1068
I ++ A R G+L+VG R+L VN S+ +H + V L++ G+T+T+ + G E+S
Sbjct: 1136 ISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEAS 1195
Query: 1069 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELER 1128
T+A + P G RN+ + E +E++ L
Sbjct: 1196 -----TDAALEVSPGVIANPFAAGIGH-RNSLESISSIDRELSPEGPGKEKELPGQTLHW 1249
Query: 1129 GAKGFGFSLRGGREYNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHS--R 1185
G + + RG + +D L + G +R G ++ E + S
Sbjct: 1250 GPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPS 1309
Query: 1186 AIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLESS 1245
EL N + R F PE P+ P GP PE + +R+++ LE
Sbjct: 1310 PDELPANVKQAYRAFAAVPTSHPPEDAPAQP---PTPGPAASPEQLSFRERQKYFELEVR 1366
Query: 1246 YPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRR 1305
P + P A D + +E + + ++
Sbjct: 1367 VPQ--AEGPPKRVSLVGADDLRKMQEEEARKLQ-------------------------QK 1399
Query: 1306 DAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSP---ERRRERSPTRR 1362
AQ R AA G + R + E ++ E+ SP R+ SP
Sbjct: 1400 RAQMLREAAEAGAEARL-------ALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPL 1452
Query: 1363 RDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNRED 1422
G+P R ++ +RR ER R SPE A RA SP R +K
Sbjct: 1453 GGGAPVRTAKA------ERRHQERLRVQSPEPPAP----ERALSPAELRALEAEK----- 1497
Query: 1423 RASHREREEANLKQDAGRS 1441
RA R +L+QDA R+
Sbjct: 1498 RALWRAARMKSLEQDALRA 1516
Score = 48.1 bits (113), Expect = 6e-05
Identities = 64/271 (23%), Positives = 106/271 (39%), Gaps = 60/271 (22%)
Query: 475 LRKSSRGFGFTVVGGDEP------DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
L +S RG GF++ GG D + + + G A G ++ GD ++S+N V
Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924
Query: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDP---DDPNTSLVTSVAILDKEPIIVNG 585
H V + + ++ LE G PLP P P T+ V + +I P
Sbjct: 925 EARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATP----- 979
Query: 586 QETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVH 645
G+ +P+ +A+ YP + + L +
Sbjct: 980 ------------------GVPGLPSLAPSLLAAALEGPYPVEEIRLPRA----------- 1010
Query: 646 IVKGPMGF----GFTIADSPGG---GGQRVKQIVDSPR----CRGLKEGDLIVEVNKKNV 694
GP+G G + P G G + +++ PR GL+ GD I+ VN ++V
Sbjct: 1011 --GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVL--PRGLAARSGLRVGDRILAVNGQDV 1066
Query: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLP 725
+ TH + V L+ E++LLV+R P
Sbjct: 1067 RDATHQEAVSALLR--PCLELSLLVRRDPAP 1095
Score = 38.9 bits (89), Expect = 0.037
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
D DE + I + G A DG++ G ++ VN +LG TH + V++ +S +G ++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS--VGDTLT 1185
Query: 550 LELCRGYPLPFD 561
+ +C G+ D
Sbjct: 1186 VLVCDGFEASTD 1197
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 83.2 bits (204), Expect = 2e-15
Identities = 69/219 (31%), Positives = 95/219 (43%), Gaps = 30/219 (13%)
Query: 1258 EKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANG 1317
E + R + RE R E T T RK + R + R E R+ QAER A+
Sbjct: 198 ENKTEDRHSERGRERER---ERETETETERKRQTDRERDRQRKTEREREKQAERERASER 254
Query: 1318 PKRRSPEKRREGTRSADNTLERREKHEKR-----------RDVSPERRRERSPTRRRDGS 1366
R E+ RE R D +RR+K +R RD ER+RER R R+
Sbjct: 255 ETERDKERERERDRDRDR--DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERE 312
Query: 1367 PSRRR---RSLERLLEQRRSPERRRGGSPERRAK-------STDRRRARSPERRRERSLD 1416
+R+R R ER E++R ER R ER+ K +R+ R R+ ER +
Sbjct: 313 RNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Query: 1417 KRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKE 1455
+ DR S REREE +D R E+ R+ K+
Sbjct: 373 RERERDRQSAREREERERDRDRDRQK----ERERQTEKD 407
Score = 80.5 bits (197), Expect = 1e-14
Identities = 59/243 (24%), Positives = 98/243 (40%), Gaps = 16/243 (6%)
Query: 1229 EVRAGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRK 1288
E G DR+ E D K R R + +R+ R+ ++ +
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERER 193
Query: 1289 PDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRD 1348
+ +DR E R+ + ER ++R ++ R+ R + E++ + E+ +
Sbjct: 194 QREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASE 253
Query: 1349 VSPERRRERSPTRRRDGSPSRRRRSLERLLEQR--------RSPERRRGGSPER-RAKST 1399
ER +ER R RD RR++ ER +++ R ER+R ER R +
Sbjct: 254 RETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERER 313
Query: 1400 DRRRARSPERRRERSLDKRNREDRASHRERE-------EANLKQDAGRSSRHPPEQRRRP 1452
+R+R R ER RER + DR RER+ + + GR R E+ R
Sbjct: 314 NRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERER 373
Query: 1453 YKE 1455
+E
Sbjct: 374 ERE 376
Score = 79.0 bits (193), Expect = 3e-14
Identities = 59/195 (30%), Positives = 88/195 (45%), Gaps = 5/195 (2%)
Query: 1259 KRAHARDPKGSREYSRQ-PNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANG 1317
+R R+ + +R+ R+ E G R+ D R + R E R+ Q +R
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT 171
Query: 1318 PKRRSPEKRREGTRSADNTLER-REKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLER 1376
+ R E+ RE R ER REK K D ER RER R + + + R+R +R
Sbjct: 172 ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETE-TETERKRQTDR 230
Query: 1377 LLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQ 1436
+++R ER R ER ++++R R ER RER D R+R+ R RER+ +Q
Sbjct: 231 ERDRQRKTEREREKQAERE-RASERETERDKERERERDRD-RDRDRRQKERERQTDRKRQ 288
Query: 1437 DAGRSSRHPPEQRRR 1451
R +R R
Sbjct: 289 RRTERDRETERKRER 303
Score = 75.5 bits (184), Expect = 4e-13
Identities = 57/218 (26%), Positives = 85/218 (38%), Gaps = 13/218 (5%)
Query: 1251 HKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAE 1310
HK + G+ R R + R ++ E T R+ + R +DR E +RD + E
Sbjct: 46 HKDAD-GDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE 104
Query: 1311 RAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERS---------PTR 1361
R + + R EK R + + ER + + R +R RER T
Sbjct: 105 RERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTD 164
Query: 1362 RRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNRE 1421
R + R R ER E+ R R R E+ K+ DR R ER RER +
Sbjct: 165 RERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETER 224
Query: 1422 DRASHREREEANLKQDAGRSSRHPPEQRRRPYKECSTD 1459
R + RER+ ++ R E+ R +E D
Sbjct: 225 KRQTDRERDR---QRKTEREREKQAERERASERETERD 259
Score = 73.9 bits (180), Expect = 1e-12
Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 6/212 (2%)
Query: 1249 DLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQ 1308
D H+ ++ R R+ R+ E + R+ + R +DR +G+R+ +
Sbjct: 92 DRHRERQRDREKERERQTDRERDRQRE-KERNRQKERERETEREGERGRDRQTDGQRERE 150
Query: 1309 AERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPS 1368
+R A ++ E++R+ R+ ER + ++RR ER R+R + + S
Sbjct: 151 RQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERR----ERERQREKENKTEDRHS 206
Query: 1369 RRRRSLERLLEQRRSPERRRGGSPER-RAKSTDRRRARSPERRRERSLDKRNREDRASHR 1427
R R ER E ER+R ER R + T+R R + ER R + ++R R
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266
Query: 1428 EREEANLKQDAGRSSRHPPEQRRRPYKECSTD 1459
+R+ ++ R + +++RR ++ T+
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETE 298
Score = 73.6 bits (179), Expect = 1e-12
Identities = 60/222 (27%), Positives = 90/222 (40%), Gaps = 17/222 (7%)
Query: 1235 DRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGAC 1294
DR++ E + ++S +R R+ + R+ R + T RK
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 1295 RPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERR 1354
R DR E +R+ Q ER R E+ R+ R + ER + E RD ER
Sbjct: 293 R--DRETERKRERQRER--------ERERERNRKRERERERERERERQRETERDREKERE 342
Query: 1355 RERSPTRRRDGSPSRR-----RRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPER 1409
R+R D +R+ RR ER E+ R ER R + ER + DR R R ER
Sbjct: 343 RKRKRQTEMDRERNRQTGREGRRQAER--ERERERERDRQSAREREERERDRDRDRQKER 400
Query: 1410 RRERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRR 1451
R+ D+ + + RERE+ + R +Q+ R
Sbjct: 401 ERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGR 442
Score = 72.4 bits (176), Expect = 3e-12
Identities = 67/229 (29%), Positives = 93/229 (40%), Gaps = 38/229 (16%)
Query: 1258 EKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAER----AA 1313
EKR R+ RE R+ + H RK D R +DR E R ER
Sbjct: 67 EKRQTERETDRKRERRREKDRH-------RKRDRHRERQRDREKERERQTDRERDRQREK 119
Query: 1314 AANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRR------------------ 1355
N K R E REG R D + + + E++RD ER R
Sbjct: 120 ERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKER 179
Query: 1356 --ERSPTRRRDGSPSRRR--RSLERLLEQRRSPERRRGGSPE-RRAKSTDRRRARSPERR 1410
E++ RR+ R + ++ +R E+ R ER R E R + TDR R R +R+
Sbjct: 180 EREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDR--QRK 237
Query: 1411 RERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKECSTD 1459
ER +K+ +RAS RE E K+ R RR+ +E TD
Sbjct: 238 TEREREKQAERERASERETERD--KERERERDRDRDRDRRQKERERQTD 284
Score = 68.9 bits (167), Expect = 3e-11
Identities = 60/197 (30%), Positives = 87/197 (44%), Gaps = 11/197 (5%)
Query: 1260 RAHARDPKGSREYSRQPN-EHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGP 1318
R R K RE +Q E + T R + R +DR + R Q ER +
Sbjct: 230 RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR---QKERERQTDRK 286
Query: 1319 KRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSR---RRRSLE 1375
++R E+ RE R + ER + E+ R ER RER R+R+ R R R +
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK 346
Query: 1376 RLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNRE-DRASHREREEANL 1434
R E R R+ G R+A+ +R R R +R+ R ++R R+ DR +ERE
Sbjct: 347 RQTEMDRERNRQTGREGRRQAE-RERERERERDRQSAREREERERDRDRDRQKERERQTE 405
Query: 1435 KQDAGRSSRHPPEQRRR 1451
K G+ R +QR R
Sbjct: 406 KDRDGQ--RETEKQRER 420
Score = 65.5 bits (158), Expect = 4e-10
Identities = 60/197 (30%), Positives = 81/197 (41%), Gaps = 26/197 (13%)
Query: 1287 RKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERR---EKH 1343
R+P S + + +DA + +R ++R+ R D ERR ++H
Sbjct: 29 RRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRH 88
Query: 1344 EKR-----RDVSPERRRERSPTRRRDGSPSR-RRRSLERLLEQRRSPERRR----GGSPE 1393
KR R E+ RER R RD + R R ER E R ER R G E
Sbjct: 89 RKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRE 148
Query: 1394 R---------RAKSTDRRRARSPERRR--ERSLDKRNREDRASHREREEANLKQDAGRSS 1442
R R + TDR R R ER R ER +K +E R R+RE+ N +D R S
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTED--RHS 206
Query: 1443 RHPPEQRRRPYKECSTD 1459
E+ R E T+
Sbjct: 207 ERGRERERERETETETE 223
Score = 59.7 bits (143), Expect = 2e-08
Identities = 54/202 (26%), Positives = 83/202 (41%), Gaps = 24/202 (11%)
Query: 1235 DRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGAC 1294
DR++ E + + +R R+ K RE R+ E T R +
Sbjct: 284 DRKRQRRTERDRETERKRERQRERERERERNRKRERERERE-RERERQRETERDREKERE 342
Query: 1295 RPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERR 1354
R + R E D + R G RR E+ RE R D RE+ E+ RD +R+
Sbjct: 343 RKRKRQTE--MDRERNRQTGREG--RRQAERERERERERDRQ-SAREREERERDRDRDRQ 397
Query: 1355 --RERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRE 1412
RER + RDG +R E+ E+ + E RG R R R E+++
Sbjct: 398 KERERQTEKDRDG-----QRETEKQREREKDRESERG-----------RERGREREKQKG 441
Query: 1413 RSLDKRNREDRASHREREEANL 1434
R D+ + DR + R+R+ + L
Sbjct: 442 RERDRERQTDRQAGRQRKRSTL 463
Score = 57.8 bits (138), Expect = 8e-08
Identities = 46/160 (28%), Positives = 72/160 (45%), Gaps = 17/160 (10%)
Query: 1306 DAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRR---------DVSPERRRE 1356
D R + P+RR + + D R+++ E+RR D ERRRE
Sbjct: 25 DFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE 84
Query: 1357 RSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPER---RAKSTDRRRARSPERRRER 1413
+ R+RD R R +R E+ R +R R E+ R K +R R ER R+R
Sbjct: 85 KDRHRKRD---RHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDR 141
Query: 1414 SLD-KRNRE-DRASHREREEANLKQDAGRSSRHPPEQRRR 1451
D +R RE R + +ERE ++ ++ R+ ++R R
Sbjct: 142 QTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERER 181
Score = 50.1 bits (118), Expect = 2e-05
Identities = 34/134 (25%), Positives = 62/134 (46%), Gaps = 6/134 (4%)
Query: 1325 KRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSP 1384
+RR G++ + + H+ ER R++ RRR+ + R +R + +
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDR 87
Query: 1385 ERRRGGSPER---RAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAGRS 1441
R+R ER R K +R+ R +R+RE+ +++ +R + RE E +Q G+
Sbjct: 88 HRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQR 147
Query: 1442 SRHPPEQRRRPYKE 1455
R E++R KE
Sbjct: 148 ER---ERQRDAEKE 158
Score = 43.5 bits (101), Expect = 0.001
Identities = 49/213 (23%), Positives = 80/213 (37%), Gaps = 14/213 (6%)
Query: 1235 DRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGAC 1294
DR + + ++ + R R + RE R+ + R+ D
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD---- 391
Query: 1295 RPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERR 1354
R +DR E R + +R K+R EK RE R + ER ++ + RD ER+
Sbjct: 392 RDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERD--RERQ 449
Query: 1355 RERSPTRRRDGS-------PSRRRRSLERLLEQRRSPERRRGGSPE-RRAKSTDRRRARS 1406
+R R+R S P R + + R + R SPE +A ST R
Sbjct: 450 TDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRP 509
Query: 1407 PERRRERSLDKRNREDRASHREREEANLKQDAG 1439
+ R R +R E R + + ++ +G
Sbjct: 510 AKASRGRVAGRRRWEPRLGEKRGQGGEGRRPSG 542
>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
Length = 1076
Score = 82.8 bits (203), Expect = 2e-15
Identities = 169/801 (21%), Positives = 291/801 (36%), Gaps = 112/801 (13%)
Query: 426 TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFT 485
T+D S PP R + P E KG + ++K G T
Sbjct: 17 TKDESPYTKSASQTKPPDGALAVRRQSI---------PEEFKGSTVVELMKKEGTTLGLT 67
Query: 486 VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545
V GG + D ++ +L G AA +++ GD I +VN + H +++ + +++ G
Sbjct: 68 VSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNV--G 125
Query: 546 ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP----IIVNGQETYDS---------- 591
V LE+ P P + T L KE ++ G D
Sbjct: 126 ERVVLEVEYELP-PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
Query: 592 --PASHSSKTGKVN--------------GMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
P + + G + G A S + VS+ S+
Sbjct: 185 VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSV 244
Query: 636 ATQPELITVHIVKGP-MGFGFTIADSPGGGGQ-----RVKQIVDSPRCRGLKEGDLIVEV 689
AT + V + K P G + S Q ++K + RC L GD I+ +
Sbjct: 245 ATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSI 304
Query: 690 NKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSV 749
+ +++ T + L ++ +L + K P L SS S
Sbjct: 305 DGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ-TRLALKGPDHAALV------SSSFSP 357
Query: 750 SSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKI---WAQSRSMYENRL 806
+S + +S + T LP + +P T + K FK A S ++
Sbjct: 358 TSMSAYSLSSLNMGT--LPR--SLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQV 413
Query: 807 PDYQEQDIFLWRKE-TGFGFRILGGNEPGE----PIYIGHIVPLGAADTDGRLRSGDELI 861
+ ++ L TGFG ++ G E P I +I A+ G L+ GD ++
Sbjct: 414 VHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVM 473
Query: 862 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAV-----------PKTENEVPS 910
++G P + + QL++ ++ V L + V +V PK N
Sbjct: 474 AINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKHNVELG 533
Query: 911 PASSHHSSNQPASLTEEKRTPQGS-QNSLNTVSSGSG--STSGIGSGGGGGSGVVSTVVQ 967
S SS +P +GS + T+ G + I V + Q
Sbjct: 534 ITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQ 593
Query: 968 PYDV---EIRRGEN-----EGFGFVIVSSVSRPEAG----TTFGNACVAMPHKIGRIIEG 1015
D+ +IR+ E+ E G +I + + G T G P I + +G
Sbjct: 594 CEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKG 653
Query: 1016 SPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT---- 1071
A+R G + +GDRILA+N S+ K S+ ++L++ AG TVTL+I ++ +A+
Sbjct: 654 GLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLLQMAGETVTLKIKKQTDAQSASSPKK 713
Query: 1072 --LLTNAEKIATITTTHTPSQQ--GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELE 1127
+ ++ + + +P+Q+ + +T P +S A D ++
Sbjct: 714 FPISSHLSDLGDVEEDSSPAQKPGKLSDMYPSTVPSVDS--------AVDSWDGSAIDTS 765
Query: 1128 RGAKGFGFSLRGGREYNMDLY 1148
G +G F G YN + Y
Sbjct: 766 YGTQGTSFQASG---YNFNTY 783
Score = 79.7 bits (195), Expect = 2e-14
Identities = 97/433 (22%), Positives = 159/433 (36%), Gaps = 75/433 (17%)
Query: 837 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 896
I I I AD G L GD ++ +DGT + + Q + Q + + +
Sbjct: 278 IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ 337
Query: 897 VVFAVPKTENEVPSPASSHHSSNQPASLTE----------EKRTPQGSQNSLNTVSSGSG 946
A+ ++ +S +S SL+ +P+G+
Sbjct: 338 TRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFK 397
Query: 947 STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMP 1006
S+ + S G +G V + +V + GFG + SV F ++ P
Sbjct: 398 SSLSLASSTVGLAGQV-VHTETTEVVLTADPVTGFGIQLQGSV--------FATETLSSP 448
Query: 1007 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLR---- 1060
I I SPA+RCG L++GDR++A+NG + + + L++++ T VTL
Sbjct: 449 PLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFD 508
Query: 1061 ----IIPGDESSNATLLTNAEKIATITTTHTPSQQ-------------------GT---- 1093
+IP + + L IT + S++ GT
Sbjct: 509 VAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELG 568
Query: 1094 -----------------------QETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1130
Q+ + K K + Q + YTVEL+R
Sbjct: 569 DKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYG 628
Query: 1131 KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1190
G ++ G E + + L + G AER G + IGD IL IN + K S AI L+
Sbjct: 629 GPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 688
Query: 1191 KNGGRRVRLFLKR 1203
+ G V L +K+
Sbjct: 689 QMAGETVTLKIKK 701
Score = 74.7 bits (182), Expect = 6e-13
Identities = 103/479 (21%), Positives = 182/479 (37%), Gaps = 75/479 (15%)
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIF-LWRKE-TGFGFRILGGNEPGEPIY 838
T S+ Q KP + + +S+ E +++ + L +KE T G + GG +
Sbjct: 24 TKSASQTKPPDGALAVRRQSIPE----EFKGSTVVELMKKEGTTLGLTVSGGIDKDGKPR 79
Query: 839 IGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNL------- 891
+ ++ G A +L GD + V+G + H ++ L++ ++ + +
Sbjct: 80 VSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEVEYELPPV 139
Query: 892 ------TVRRKVVFAVPKTENE----VPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 941
+ R V + K N + A + ++P +T + P G + T+
Sbjct: 140 SVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVR--PGGPADREGTI 197
Query: 942 SSGSG--STSGIGSGGGGGSGVVSTVVQ---------PYDVEIRRGENEGFGFVIVSSVS 990
G S GI G + +S + Q YDV + G ++V
Sbjct: 198 KPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAK 257
Query: 991 RPEAGT----TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDI 1046
P A T C I +I S ADRCG L VGD IL+++G S+ + ++
Sbjct: 258 TPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEA 317
Query: 1047 VNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP------------------ 1088
+ + V L I+P ++ A L + A ++++ +P
Sbjct: 318 TQFLANTTDQVKLEILPHHQTRLA--LKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPR 375
Query: 1089 -----SQQGTQETRNTTKPKQESQFEFK------APQATQEQDFYTVELERGAKGFGFSL 1137
S +GT R K +S A Q + V GFG L
Sbjct: 376 SLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQL 435
Query: 1138 RGG----REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
+G + + + D PAERCG ++IGD ++ ING T++ A +L+++
Sbjct: 436 QGSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRD 494
Score = 61.2 bits (147), Expect = 7e-09
Identities = 55/227 (24%), Positives = 91/227 (40%), Gaps = 65/227 (28%)
Query: 1008 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1067
++ + +G A R +L VGD I AVNG ++ H +I++L+K G V L +
Sbjct: 79 RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV------ 132
Query: 1068 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD---FYTV 1124
E++ P + + F TV
Sbjct: 133 -----------------------------------------EYELPPVSVQGSSVIFRTV 151
Query: 1125 ELERGAKG--FGFSLRGG----REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1178
E+ +G FGF +RGG R + + + + GPA+R G ++ GD +L ++G
Sbjct: 152 EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
Query: 1179 KNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPS-SDRHGPATGP 1224
H+ A+ ++K G+ L + EYD S D A+GP
Sbjct: 212 LGTTHAEAMSILKQCGQEAALLI--------EYDVSVMDSVATASGP 250
Score = 51.6 bits (122), Expect = 5e-06
Identities = 71/317 (22%), Positives = 120/317 (37%), Gaps = 72/317 (22%)
Query: 963 STVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCG 1022
S + + +V + + E FGFVI G + + P I + G PADR G
Sbjct: 145 SVIFRTVEVTLHK-EGNTFGFVI--------RGGAHDDRNKSRPVVITCVRPGGPADREG 195
Query: 1023 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATI 1082
+K GDR+L+V+G + +H++ ++++K+ G L +I D S ++ T + +
Sbjct: 196 TIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAAL-LIEYDVSVMDSVATASGPLLVE 254
Query: 1083 TTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGRE 1142
K P A+ G +L
Sbjct: 255 VA--------------------------KTPGAS----------------LGVALTTSMC 272
Query: 1143 YNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1201
N + V+ ++ A+RCG + +GD IL I+G + + + A + + N +V+L
Sbjct: 273 CNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL-- 330
Query: 1202 KRGDGSVPEYDPSSDRHGPATGPQGVPEVRA--GPDRRQHPSLES----SYPPDLHKSSP 1255
E P GP V + P SL S + P L+ +SP
Sbjct: 331 --------EILPHHQTRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSP 382
Query: 1256 HG---EKRAHARDPKGS 1269
G +R +D K S
Sbjct: 383 RGTMMRRRLKKKDFKSS 399
Score = 41.6 bits (96), Expect = 0.006
Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 12/127 (9%)
Query: 1073 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1132
LT E T + + T G R + P+ EFK + +++
Sbjct: 16 LTKDESPYTKSASQTKPPDGALAVRRQSIPE-----EFKGSTVVEL-------MKKEGTT 63
Query: 1133 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1192
G ++ GG + + V L + G A R ++ +GD I +NG +H I L+KN
Sbjct: 64 LGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKN 123
Query: 1193 GGRRVRL 1199
G RV L
Sbjct: 124 VGERVVL 130
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 82.0 bits (201), Expect = 4e-15
Identities = 75/222 (33%), Positives = 98/222 (44%), Gaps = 25/222 (11%)
Query: 1235 DRRQHPSLESSYPPDLHKSS-PHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGA 1293
DRR S + K P A K +R SR+P S KP +
Sbjct: 304 DRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKS 363
Query: 1294 CRPKDRAPEGRRDAQAERAAAANGP-----------KRRSPEKRR---EGTRSADNTLER 1339
R + RR Q++ + P KRR PE+RR TR D+ L R
Sbjct: 364 RRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSR 423
Query: 1340 REKHEKRRDV---SPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRA 1396
RE+ + + SP RRR RSP RRR SP RR RS R + RSP RR G RR+
Sbjct: 424 RERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRR---RSRSPRRRDRG---RRS 477
Query: 1397 KSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDA 1438
+S RRR+RS RR RS K +ED+ E ++Q++
Sbjct: 478 RSRLRRRSRSRGGRRRRSRSK-VKEDKFKGSLSEGMKVEQES 518
Score = 79.7 bits (195), Expect = 2e-14
Identities = 75/252 (29%), Positives = 110/252 (43%), Gaps = 25/252 (9%)
Query: 1214 SSDRHGPATGPQG----VPEVRAGPDRRQHPSLESSYPPDLHKSS--------PHGEKRA 1261
S ++ G A P + + DR++ P + S D K S ++R+
Sbjct: 248 SQEKIGKARSPTDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRS 307
Query: 1262 HARDPKGSR---EYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGR------RDAQAERA 1312
+++ K R + ++P + + + +S K + R R+P+ R RD
Sbjct: 308 RSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSR 367
Query: 1313 AAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSP-TRRRDGSPSRRR 1371
+ +R K T S + R KRR+ PERRR SP TR RD SRR
Sbjct: 368 SPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRRE--PERRRLSSPRTRPRDDILSRRE 425
Query: 1372 RSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREE 1431
RS + R SP RRR SP RR + RR+RSP RRR RS +R+R R+ R R
Sbjct: 426 RSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSP-RRRSRSPRRRDRGRRSRSRLRRR 484
Query: 1432 ANLKQDAGRSSR 1443
+ + R SR
Sbjct: 485 SRSRGGRRRRSR 496
Score = 67.8 bits (164), Expect = 7e-11
Identities = 69/229 (30%), Positives = 93/229 (40%), Gaps = 37/229 (16%)
Query: 1252 KSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQA-- 1309
K S KR+ ++D + G +R P + +D++ R
Sbjct: 221 KKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSPTDDKVKIEDKSKSKDRKKSPII 280
Query: 1310 -ERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPER-------------RR 1355
E + G K RSP R +S D +E+ KR + E+ +
Sbjct: 281 NESRSRDRGKKSRSPVDLRG--KSKDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKE 338
Query: 1356 ERSPTRRRDGSPSRR----------RRSLERLLEQRRSPERR---RGGSPERRAKSTD-R 1401
RSP+RR SP RR RRS LL RRS + + R SP RRAKS
Sbjct: 339 NRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLE 398
Query: 1402 RRARSPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRR 1450
R+ R PERRR S R R+D S RER +DA +R P +RR
Sbjct: 399 RKRREPERRRLSSPRTRPRDDILSRRER-----SKDASPINRWSPTRRR 442
Score = 57.0 bits (136), Expect = 1e-07
Identities = 60/209 (28%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 1252 KSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAER 1311
KS K++ + SR+ ++ G S+ S + K + E ++ + +
Sbjct: 268 KSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPIK 327
Query: 1312 AA---AANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSP---ERRRERSPTRRRDG 1365
+ A++G + RSP RR G +L + + + RR SP +RR ++S + R
Sbjct: 328 SPSKDASSGKENRSPS-RRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSRTL 386
Query: 1366 SPSRRR--RSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDR 1423
SP RR RSLER +RR PERRR SP R + R RERS D
Sbjct: 387 SPGRRAKSRSLER---KRREPERRRLSSPRTRPRDDILSR-------RERSKDASPINRW 436
Query: 1424 ASHREREEANLKQDAGRSSRHPPEQRRRP 1452
+ R R + ++ R SR P + R P
Sbjct: 437 SPTRRRSRSPIR----RRSRSPLRRSRSP 461
Score = 51.2 bits (121), Expect = 7e-06
Identities = 33/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Query: 1320 RRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLE 1379
R +K + G R + E+++ SP +R + R+ SP+ RRRS E++ +
Sbjct: 195 RSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGK 254
Query: 1380 QRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDKRNREDRASHREREEANLKQDAG 1439
R + + E ++KS DR+++ R R K++R + ++ +
Sbjct: 255 ARSPTDDK--VKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKER 312
Query: 1440 RSSRHPPEQRRRPYKECSTDLS 1461
+S R ++ ++P K S D S
Sbjct: 313 KSKRSETDKEKKPIKSPSKDAS 334
Score = 45.1 bits (105), Expect = 5e-04
Identities = 50/216 (23%), Positives = 88/216 (40%), Gaps = 19/216 (8%)
Query: 1251 HKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRR---DA 1307
++S E H + G+R +R + K + R K R+ E R D
Sbjct: 140 YESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKK-RSKSRSKERTRHRSDK 198
Query: 1308 QAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSPERRRE--------RSP 1359
+ + ++ + K +E +S + + + + R+ SP RR RSP
Sbjct: 199 KKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKSPTLRRRSQEKIGKARSP 258
Query: 1360 T----RRRDGSPSRRRRSLERLLEQRRSPERRRGGSP-ERRAKSTDRRRARSPERRRERS 1414
T + D S S+ R+ + E R ++ SP + R KS DRR +RS ER+ +RS
Sbjct: 259 TDDKVKIEDKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRR-SRSKERKSKRS 317
Query: 1415 -LDKRNREDRASHREREEANLKQDAGRSSRHPPEQR 1449
DK + ++ ++ + R P++R
Sbjct: 318 ETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRR 353
Score = 36.2 bits (82), Expect = 0.24
Identities = 53/230 (23%), Positives = 85/230 (36%), Gaps = 47/230 (20%)
Query: 1251 HKSSPHGEKRAHARDPKGSREYSRQPNEH-HTWNGTSRKPDSGACRPKDRAPEGR----- 1304
HK H + H + S E + ++H H RK A + +P R
Sbjct: 43 HKKKKHKHRSKHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDD 102
Query: 1305 ----RDAQAERAAAANGPKRRSPEKRREGTRSADNTL----------ERREKHEKRRDVS 1350
D + +RA K + EG + L E E HEK R+ +
Sbjct: 103 LALLEDLEKQRALI----KAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGN 158
Query: 1351 PERRRERSPTRRR---DGSPSRRRRSLERLLEQRR---SPERRRGGSPERRAKSTDRRRA 1404
R S + D + ++RS R E+ R ++ +GG + K+T R+
Sbjct: 159 RSSTRSSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKEKTT---RS 215
Query: 1405 RSPERRRERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYK 1454
+S ER++ +S KR++ QD R S+ P +RR K
Sbjct: 216 KSKERKKSKSPSKRSKS--------------QDQARKSKSPTLRRRSQEK 251
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 81.3 bits (199), Expect = 6e-15
Identities = 91/386 (23%), Positives = 152/386 (39%), Gaps = 86/386 (22%)
Query: 680 LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK 739
L D ++ +N +++ T ++ G V L + R G P P + + E
Sbjct: 381 LSSNDRVLAINGHDLKYGTPELAAQIIQA--SGERVNLTIARPGKPQPGNTIR----EAG 434
Query: 740 DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR 799
+ +SSQH HT P +S +P K Q
Sbjct: 435 NHSSSSQH--------HTPPPYYS------------------------RPSSHKDLTQCV 462
Query: 800 SMYENRLPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PIYIGHIVPLGAADTDGRLRS 856
+ E + +E G + GG ++ GE PI++ + P G DGR++
Sbjct: 463 TCQEKHITVKKEP-------HESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKR 515
Query: 857 GDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHH 916
GD L+ ++G + SH V +++ +A V A+ E ++ A+ +
Sbjct: 516 GDVLLNINGIDLTNLSHSEAVAMLKASAASPAV----------ALKALEVQIVEEATQN- 564
Query: 917 SSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRG 976
+ QP++ +E + S + + + G+ ST+ +D+ +RR
Sbjct: 565 AEEQPSTFSENEYDASWSPSWVMWL------------------GLPSTLHSCHDIVLRRS 606
Query: 977 ENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGC 1036
+GF IV P I I+ G+PA G+LK GD I+AVNG
Sbjct: 607 YLGSWGFSIVGGYEENHTN---------QPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGL 657
Query: 1037 SITNKSHSDIVNLIKEAGNTVTLRII 1062
S SHS +V ++KE N VTL +I
Sbjct: 658 STVGMSHSALVPMLKEQRNKVTLTVI 683
Score = 77.0 bits (188), Expect = 1e-13
Identities = 84/382 (21%), Positives = 154/382 (40%), Gaps = 56/382 (14%)
Query: 831 NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVN 890
+EPG ++I ++ G A DGRL S D ++ ++G + + +L Q++Q + ++ VN
Sbjct: 360 DEPG--VFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGER--VN 415
Query: 891 LTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSG 950
LT+ R P+ N + A +H SS+Q + P ++ V+
Sbjct: 416 LTIARP---GKPQPGNTIRE-AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC------- 464
Query: 951 IGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIG 1010
Q + +++ +E G + G+ +P +
Sbjct: 465 ----------------QEKHITVKKEPHESLGMTVAGGR---------GSKSGELPIFVT 499
Query: 1011 RIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNA 1070
+ R G++K GD +L +NG +TN SHS+ V ++K + +S A
Sbjct: 500 SVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASA------------ASPA 547
Query: 1071 TLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1130
L E T +Q + + N + + + + L R
Sbjct: 548 VALKALEVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSY 607
Query: 1131 KG-FGFSLRGGREYN---MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRA 1186
G +GFS+ GG E N ++ + PA G+++ GD I+ +NG +T M HS
Sbjct: 608 LGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSAL 667
Query: 1187 IELIKNGGRRVRLFLKRGDGSV 1208
+ ++K +V L + GS+
Sbjct: 668 VPMLKEQRNKVTLTVICWPGSL 689
Score = 59.3 bits (142), Expect = 3e-08
Identities = 112/493 (22%), Positives = 184/493 (37%), Gaps = 138/493 (27%)
Query: 483 GFTVVGGDE-PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV--LGHTHAQVV--- 536
G ++VGG+E P + I+ + DG A DG++ GD I+ VN+ + + H +A+ V
Sbjct: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
Query: 537 ------------------------------KIFQ----SIPIGASVDLELCRGYPLP--F 560
+IFQ G + ++L R P F
Sbjct: 306 PCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF 365
Query: 561 DPDDPNTSLVTSVAILDKEP--IIVNGQE-TYDSP---ASHSSKTGKVNGMKDARPSSP- 613
D L L + +NG + Y +P A +G+ + ARP P
Sbjct: 366 ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
Query: 614 --------ADVASNSSHGYPNDTVSLASSIATQPELIT-----VHIVKGP-MGFGFTIAD 659
+ +S+S H P S SS + +T + + K P G T+A
Sbjct: 426 PGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG 485
Query: 660 SPGGGGQRVKQIVDSPRCRG-------LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKG 712
G + V S G +K GD+++ +N ++ L+H++ V ML
Sbjct: 486 GRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML------ 539
Query: 713 SEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPP 772
ASP+ + + L
Sbjct: 540 -----------------------------------------KASAASPAVALKAL----- 553
Query: 773 AEAQAPDQTDSSGQKKPDPFK------IWAQSRSMYENRLPD--YQEQDIFLWRKETG-F 823
E Q ++ + +++P F W+ S M+ LP + DI L R G +
Sbjct: 554 -EVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLG-LPSTLHSCHDIVLRRSYLGSW 611
Query: 824 GFRILGG---NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLM 880
GF I+GG N +P +I IV A DGRL+ GD ++ V+G +G SH +V ++
Sbjct: 612 GFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPML 671
Query: 881 QQAAKQGHVNLTV 893
++ ++ V LTV
Sbjct: 672 KE--QRNKVTLTV 682
Score = 58.9 bits (141), Expect = 3e-08
Identities = 50/214 (23%), Positives = 94/214 (43%), Gaps = 14/214 (6%)
Query: 1012 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1071
++EG A + G+L DR+LA+NG + + +I+ +G V L I +
Sbjct: 369 LLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGN 428
Query: 1072 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1131
+ A ++ + HTP ++ + + K +Q T ++ TV+ E +
Sbjct: 429 TIREAGNHSSSSQHHTPPPYYSRPSSH----KDLTQC------VTCQEKHITVKKEPH-E 477
Query: 1132 GFGFSLRGGR---EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1188
G ++ GGR + ++V + G R G+++ GD +L ING N+ HS A+
Sbjct: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
Query: 1189 LIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPAT 1222
++K + LK + + E + P+T
Sbjct: 538 MLKASAASPAVALKALEVQIVEEATQNAEEQPST 571
Score = 49.3 bits (116), Expect = 3e-05
Identities = 28/70 (40%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 475 LRKSSRG-FGFTVVGGDEPDEFLQ---IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
LR+S G +GF++VGG E + Q IK++VL PA DG+++ GD+IV+VN +G
Sbjct: 603 LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGM 662
Query: 531 THAQVVKIFQ 540
+H+ +V + +
Sbjct: 663 SHSALVPMLK 672
Score = 47.8 bits (112), Expect = 8e-05
Identities = 49/211 (23%), Positives = 78/211 (36%), Gaps = 48/211 (22%)
Query: 1020 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI 1079
R G+L GD+IL VN +I+N SH+ ++ + NT+ L ++ +
Sbjct: 273 RDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVL------------RERRF 320
Query: 1080 ATITTTHTPSQQGTQETRNTTKPKQES--QFEFKAPQATQEQDFYTVELERGAKGFGFSL 1137
H+ S +E K++S Q K + T E
Sbjct: 321 GNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------------------ 362
Query: 1138 RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRV 1197
+++L L E G A + G++ D +L ING K A ++I+ G RV
Sbjct: 363 --------GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERV 414
Query: 1198 RLFLKRGDGSVP--------EYDPSSDRHGP 1220
L + R P + SS H P
Sbjct: 415 NLTIARPGKPQPGNTIREAGNHSSSSQHHTP 445
Score = 38.5 bits (88), Expect = 0.048
Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 1113 PQATQEQDFYTVELERGAK--GFGFSLRGGREYNM-DLYVLRLAEDGPAERCGKMRIGDE 1169
P + E + T+E+ R G S+ GG E + ++ + + DG R G++ GD+
Sbjct: 223 PLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQ 282
Query: 1170 ILEINGETTKNMKHSRA 1186
IL++N N+ H+ A
Sbjct: 283 ILQVNNYNISNVSHNYA 299
Score = 37.7 bits (86), Expect = 0.082
Identities = 31/99 (31%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 824 GFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882
G I+GGNE P I I + G DGRL +GD+++ V+ + SH ++ Q
Sbjct: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
Query: 883 AAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 921
H LTV R E + A +H SN P
Sbjct: 306 PCNTLH--LTVLR---------ERRFGNRAHNHSDSNSP 333
Score = 35.4 bits (80), Expect = 0.41
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 12 TSRVHECTVKRGPQGELGVTVLG--GAEHGEFP-YVGAVAAVEAAGLPGGGEGPRLGEGE 68
T + TVK+ P LG+TV G G++ GE P +V +V G R+ G+
Sbjct: 463 TCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDG-----RIKRGD 517
Query: 69 LLLEVQGVRVSGLPRYDVLGVI--DSCKEAVTFKAV 102
+LL + G+ ++ L + + ++ + AV KA+
Sbjct: 518 VLLNINGIDLTNLSHSEAVAMLKASAASPAVALKAL 553
Score = 31.2 bits (69), Expect = 7.7
Identities = 20/82 (24%), Positives = 42/82 (51%), Gaps = 3/82 (3%)
Query: 473 TKLRKSSRGFGFTVVGG--DEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
T ++ G TV GG + E + + S+ G A DG+++ GDV++++N +
Sbjct: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
Query: 530 HTHAQVVKIFQSIPIGASVDLE 551
+H++ V + ++ +V L+
Sbjct: 530 LSHSEAVAMLKASAASPAVALK 551
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 79.7 bits (195), Expect = 2e-14
Identities = 59/210 (28%), Positives = 101/210 (48%), Gaps = 24/210 (11%)
Query: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------- 1061
I +IIEG A + G+L++GDR+LAVN ++ + H + V +K + V L++
Sbjct: 257 ITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLH 316
Query: 1062 -----IPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR-NTTKPKQESQFEFK-APQ 1114
P D +S T L + I+ + G E++ + P Q + P+
Sbjct: 317 LNDMYAPPDYASTFTALADNH----ISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPR 372
Query: 1115 ATQEQDFYTVE-----LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDE 1169
++ +T E L +G+ G GF++ GG E ++V + GPA+ G++R GD
Sbjct: 373 HMLAEEDFTREPRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDR 431
Query: 1170 ILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
IL +NG +N H +A +K G+ V +
Sbjct: 432 ILSVNGVNLRNATHEQAAAALKRAGQSVTI 461
Score = 69.3 bits (168), Expect = 3e-11
Identities = 66/263 (25%), Positives = 109/263 (41%), Gaps = 43/263 (16%)
Query: 813 DIFLWRKETGFGFRILGG----NEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTP 867
++ L + G GF I GG + PG+ IYI I+ GAA DGRL+ GD L+ V+ T
Sbjct: 226 EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTN 285
Query: 868 VIGKSHQLVVQLMQQAAKQGHVNL----TVRRKVVFAVPKTENEVPSPASSHHSSNQP-- 921
+ H+ V ++ + ++ + ++ ++A P + + A +H S N
Sbjct: 286 LQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLG 345
Query: 922 -----ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRG 976
S PQ + + + +P + + +G
Sbjct: 346 YLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDF-------------TREPRKIILHKG 392
Query: 977 ENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGC 1036
+ G GF IV +F I+ G PAD G+L+ GDRIL+VNG
Sbjct: 393 -STGLGFNIVGGEDGEGIFVSF-------------ILAGGPADLSGELRRGDRILSVNGV 438
Query: 1037 SITNKSHSDIVNLIKEAGNTVTL 1059
++ N +H +K AG +VT+
Sbjct: 439 NLRNATHEQAAAALKRAGQSVTI 461
Score = 68.6 bits (166), Expect = 4e-11
Identities = 67/255 (26%), Positives = 111/255 (43%), Gaps = 31/255 (12%)
Query: 641 LITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVNK 691
++ V+++KGP G GF+IA PG + +I++ + L+ GD ++ VN
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
Query: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSS 751
N+Q + H + V L V L V + G S + S+ +++
Sbjct: 284 TNLQDVRHEEAVASLKNT--SDMVYLKVAKPG------SLHLNDMYAPPDYASTFTALAD 335
Query: 752 HRSLHTASPSHSTQVLPEFP-PAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQ 810
+ H +S + V + PA Q P S P P + A+ E R
Sbjct: 336 NHISHNSSLGYLGAVESKVSYPAPPQVPPTRYS-----PIPRHMLAEEDFTREPR----- 385
Query: 811 EQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIG 870
I L + TG GF I+GG E GE I++ I+ G AD G LR GD ++ V+G +
Sbjct: 386 --KIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 442
Query: 871 KSHQLVVQLMQQAAK 885
+H+ +++A +
Sbjct: 443 ATHEQAAAALKRAGQ 457
Score = 67.8 bits (164), Expect = 7e-11
Identities = 59/235 (25%), Positives = 92/235 (39%), Gaps = 63/235 (26%)
Query: 970 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1029
++ + RG N G GF I + P G I +II G A G+L V D
Sbjct: 131 EIVLERG-NSGLGFSIAGGIDNPHVPDDPGIF-------ITKIIPGGAAAMDGRLGVNDC 182
Query: 1030 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1089
+L VN ++ HS V +KEAG V L +
Sbjct: 183 VLRVNEVDVSEVVHSRAVEALKEAGPVVRLVV---------------------------- 214
Query: 1090 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-----N 1144
+P E+ E V L +G KG GFS+ GG +
Sbjct: 215 --------RRRQPPPETIME--------------VNLLKGPKGLGFSIAGGIGNQHIPGD 252
Query: 1145 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1199
+Y+ ++ E G A++ G+++IGD +L +N ++++H A+ +KN V L
Sbjct: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYL 307
Score = 59.7 bits (143), Expect = 2e-08
Identities = 79/303 (26%), Positives = 121/303 (39%), Gaps = 43/303 (14%)
Query: 471 IHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
+ L K +G GF++ GG D + I ++ G A DG+++ GD +++VN+T
Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284
Query: 526 CVLGHTHAQVVKIFQS------IPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKE 579
+ H + V ++ + + L L Y P S T++A
Sbjct: 285 NLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP-----DYASTFTALA----- 334
Query: 580 PIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT-Q 638
D+ SH+S G + G +++ S PA + P LA T +
Sbjct: 335 ----------DNHISHNSSLGYL-GAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTRE 383
Query: 639 PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLKEGDLIVEVNKKNVQ 695
P I +H KG G GF I G G V I+ + L+ GD I+ VN N++
Sbjct: 384 PRKIILH--KGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 696 ALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSL 755
TH Q L G VT++ Q + K L R+ NSS S S SL
Sbjct: 442 NATHEQAAAALKRA--GQSVTIVAQYRPEEYSRFESKIHDL-REQMMNSSMSSGSG--SL 496
Query: 756 HTA 758
T+
Sbjct: 497 RTS 499
Score = 52.4 bits (124), Expect = 3e-06
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 5/85 (5%)
Query: 1124 VELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1178
+ LERG G GFS+ GG + + +++ ++ G A G++ + D +L +N
Sbjct: 132 IVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDV 191
Query: 1179 KNMKHSRAIELIKNGGRRVRLFLKR 1203
+ HSRA+E +K G VRL ++R
Sbjct: 192 SEVVHSRAVEALKEAGPVVRLVVRR 216
Score = 50.8 bits (120), Expect = 9e-06
Identities = 34/100 (34%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 435 PVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDE 494
P P PP+ P L + F TR P ++ L K S G GF +VGG++ E
Sbjct: 357 PAPPQVPPTRYSPIPRHMLAEEDF-TREPRKII-------LHKGSTGLGFNIVGGED-GE 407
Query: 495 FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
+ + ++ GPA L G++ GD I+SVN + TH Q
Sbjct: 408 GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 447
Score = 45.8 bits (107), Expect = 3e-04
Identities = 33/93 (35%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 809 YQEQDIFLWRKETGFGFRILGGNE----PGEP-IYIGHIVPLGAADTDGRLRSGDELICV 863
++ ++I L R +G GF I GG + P +P I+I I+P GAA DGRL D ++ V
Sbjct: 127 FKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 864 DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 896
+ V H V+ +++A V L VRR+
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPV--VRLVVRRR 217
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 462 NPSELKGKFIHTKLRKSSRGFGFTVVGG-DEP----DEFLQIKSLVLDGPAALDGKMETG 516
N S+ K+ L + + G GF++ GG D P D + I ++ G AA+DG++
Sbjct: 121 NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180
Query: 517 DVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559
D ++ VN+ V H++ V+ + G V L + R P P
Sbjct: 181 DCVLRVNEVDVSEVVHSRAVEALKE--AGPVVRLVVRRRQPPP 221
Score = 41.2 bits (95), Expect = 0.007
Identities = 20/49 (40%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR R+ EV G DY+F+ +E ++ + Q +E G + N YGT
Sbjct: 656 VPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGT 704
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,646,870
Number of Sequences: 37866
Number of extensions: 3602609
Number of successful extensions: 43753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 688
Number of HSP's successfully gapped in prelim test: 654
Number of HSP's that attempted gapping in prelim test: 20268
Number of HSP's gapped (non-prelim): 11995
length of query: 1462
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1347
effective length of database: 13,892,928
effective search space: 18713774016
effective search space used: 18713774016
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.