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Search of human proteins with 74272282
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|74272282 membrane associated guanylate kinase, WW and PDZ
domain containing 1 isoform a [Homo sapiens]
(1287 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 2606 0.0
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 2501 0.0
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 2434 0.0
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 973 0.0
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 928 0.0
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 922 0.0
gi|148746189 multiple PDZ domain protein [Homo sapiens] 127 7e-29
gi|112382257 InaD-like [Homo sapiens] 113 1e-24
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 94 1e-18
gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens] 93 2e-18
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 92 4e-18
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 92 4e-18
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 90 1e-17
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 90 2e-17
gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens] 89 4e-17
gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens] 89 4e-17
gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens] 89 4e-17
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 89 4e-17
gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens] 87 8e-17
gi|156546890 WW and C2 domain containing 2 [Homo sapiens] 87 8e-17
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 86 2e-16
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi... 84 1e-15
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 84 1e-15
gi|45827729 scribble isoform b [Homo sapiens] 83 1e-15
gi|45827731 scribble isoform a [Homo sapiens] 83 1e-15
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 80 2e-14
gi|24025688 ligand of numb-protein X 2 [Homo sapiens] 79 2e-14
gi|21361142 PDZ domain containing 1 [Homo sapiens] 79 4e-14
gi|10092691 tight junction protein 3 [Homo sapiens] 77 1e-13
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 76 2e-13
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 2606 bits (6755), Expect = 0.0
Identities = 1287/1287 (100%), Positives = 1287/1287 (100%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
Query: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
Sbjct: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
Query: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
Sbjct: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
Query: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
Sbjct: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
Query: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
Sbjct: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ
Sbjct: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
Query: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
Sbjct: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
Query: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
Sbjct: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
Query: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
Sbjct: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
Query: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE
Sbjct: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
Query: 1081 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA
Sbjct: 1081 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
Query: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE
Sbjct: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
Query: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF 1260
INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF
Sbjct: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF 1260
Query: 1261 YLMGHNQTTTPAATATAPPPVHKVFRK 1287
YLMGHNQTTTPAATATAPPPVHKVFRK
Sbjct: 1261 YLMGHNQTTTPAATATAPPPVHKVFRK 1287
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 2501 bits (6482), Expect = 0.0
Identities = 1239/1240 (99%), Positives = 1239/1240 (99%), Gaps = 1/1240 (0%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
Query: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
Sbjct: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
Query: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
Sbjct: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
Query: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
Sbjct: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
Query: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
Sbjct: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ
Sbjct: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
Query: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
Sbjct: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
Query: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
Sbjct: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
Query: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
Sbjct: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
Query: 1021 EAGTTF-GNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1079
EAGTTF GNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK
Sbjct: 1021 EAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1080
Query: 1080 EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK 1139
EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK
Sbjct: 1081 EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK 1140
Query: 1140 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1199
APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL
Sbjct: 1141 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL 1200
Query: 1200 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1239
EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY
Sbjct: 1201 EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY 1240
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 2434 bits (6308), Expect = 0.0
Identities = 1217/1283 (94%), Positives = 1226/1283 (95%), Gaps = 31/1283 (2%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
Sbjct: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
Sbjct: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
Sbjct: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
Sbjct: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
Sbjct: 241 EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG 300
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
Sbjct: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE 360
Query: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
Sbjct: 361 LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ 420
Query: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
Sbjct: 421 QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR 480
Query: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
Sbjct: 481 GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ 540
Query: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
Sbjct: 541 SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG 600
Query: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
Sbjct: 601 KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS 660
Query: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
Sbjct: 661 PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
Sbjct: 721 RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ 780
Query: 781 TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ 840
TDSSGQKKPDPFKIWAQSRSMYENR +PDYQEQ
Sbjct: 781 TDSSGQKKPDPFKIWAQSRSMYENR----------------------------LPDYQEQ 812
Query: 841 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
Sbjct: 813 DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 872
Query: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
Sbjct: 873 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 932
Query: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
Sbjct: 933 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 992
Query: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE
Sbjct: 993 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1052
Query: 1081 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA
Sbjct: 1053 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1112
Query: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE
Sbjct: 1113 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1172
Query: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF 1260
INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEY + + E
Sbjct: 1173 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEV-- 1230
Query: 1261 YLMGHNQTTTPAATATAPPPVHK 1283
G ++ P+ ++ PP +HK
Sbjct: 1231 -RAGPDRRQHPSLESSYPPDLHK 1252
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 973 bits (2516), Expect = 0.0
Identities = 560/1138 (49%), Positives = 732/1138 (64%), Gaps = 121/1138 (10%)
Query: 1 MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE 60
MSK ++KK+HWTS+VHE + R P+G+LG + GGAE+G+FPY+G V + A
Sbjct: 1 MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAY----ES 56
Query: 61 GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF 120
G +L ELLLEV V+GL DVL VI CK+ + K V+QGG ++KDLRH+LN RF
Sbjct: 57 GSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRF 116
Query: 121 QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG 180
QKGS DHELQQ IRDNLY VPCTTR +EGEVPGVDY F+TV++F++LE+SG LLE G
Sbjct: 117 QKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESG 176
Query: 181 TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE 240
TYE NYYGTPKPP++P + TD + + S + KR KS ++M+ A I E EE
Sbjct: 177 TYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVSNMEKASIEPPE-EE 235
Query: 241 EDDVPEMNSSFTADSGEQEEHTLQET-ALPPVNSSIIAAPITDPSQKFPQYL----PLSA 295
E++ P +N + + E EH + A + S AP+ ++ + + P
Sbjct: 236 EEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEELKEQMDDTKPTKP 295
Query: 296 EDN--LGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
EDN PLP+NWEMAYTE GEVYFIDHNTKTTSWLDPR L K+ KP EEC+++
Sbjct: 296 EDNEEPDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPR-LAKKAKPPEECKEN------ 348
Query: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
ELP GWEKI+DP+YG YYVDHINR+TQ+ENPVLEAKRK
Sbjct: 349 ------ELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRK---------------- 386
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
QQ TE T +P + + KP FTR+ S+LKG F+ T
Sbjct: 387 LQQHNMPHTELGT-------------------KPLQAPGFREKPLFTRDASQLKGTFLST 427
Query: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
L+KS+ GFGFT++GGDEPDEFLQ+KS++ DGPAA DGKMETGDVIV +N+ CVLGHTHA
Sbjct: 428 TLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHA 487
Query: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK-EPIIVNGQETYDSP 592
VVK+FQS+PIG SV+L LCRGYPLPFDP+DP S+V +AI+++ P++VNG+ Y++
Sbjct: 488 DVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETY 547
Query: 593 ASHSSKTGK-VNGMKDARP----SSPADVASNSSHGYP--NDTVSLASSIATQPELITVH 645
+ S+T + V + D P S P D + ++ P +D VS+ASS ATQ EL+T+
Sbjct: 548 LEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQAELMTLT 607
Query: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDM 705
IVKG GFGFTIADSP GQRVKQI+D C GL EGDLIVE+N++NVQ L+H +VVD+
Sbjct: 608 IVKGAQGFGFTIADSP--TGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDI 665
Query: 706 LVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQ 765
L +CP GSE +L++ RGG P K+PK ++R ++Q S Q S+S+ A P Q
Sbjct: 666 LKDCPIGSETSLIIHRGGFFSPWKTPK-PIMDRWENQGSPQTSLSA-----PAIP----Q 715
Query: 766 VLPEFPPA--EAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823
LP FPPA + PD T++ +KPDP++++ +SR++YE+R P S
Sbjct: 716 NLP-FPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTS--------FR 766
Query: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLR 883
++S+ PDY+E D+ L R E+GFGFRILGG+EPG+PI IG ++ +G+AD DGRL
Sbjct: 767 MDSSG------PDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLH 820
Query: 884 SGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVF-AVPKTEN-EVPSPAS 941
GDEL+ VDG PV GK+H+ V+ LM AA+ G VNLTVRRKV+ P EN P S
Sbjct: 821 PGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVS 880
Query: 942 SHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 1001
+HHSS R+ + + N + S ++ G S +Q DV I
Sbjct: 881 THHSS---------PRSDYATYTNSNHAAPSSNASP--------PEGFASHSLQTSDVVI 923
Query: 1002 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1061
R ENEGFGFVI+SS++RPE+G+T + +PHKIGRII+GSPADRC KLKVGDRILAV
Sbjct: 924 HRKENEGFGFVIISSLNRPESGST-----ITVPHKIGRIIDGSPADRCAKLKVGDRILAV 978
Query: 1062 NGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQ 1119
NG SI N H+DIV LIK+AG +VTLRIIP +E ++ T ++EK + + +QQ
Sbjct: 979 NGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQ 1036
Score = 155 bits (391), Expect = 3e-37
Identities = 80/150 (53%), Positives = 103/150 (68%)
Query: 1135 QFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRI 1194
Q+ + Q+ D++TV++E+GAKGFGFS+RGGREY MDLYVLRLAEDGPA R G+MR+
Sbjct: 1131 QYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRV 1190
Query: 1195 GDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEK 1254
GD+I+EINGE+T++M H+RAIELIK+GGRRVRL LKRG G VPEY P +
Sbjct: 1191 GDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYDEPAPWSSPAAAAPG 1250
Query: 1255 LGEACFYLMGHNQTTTPAATATAPPPVHKV 1284
L E L +P+ A P H++
Sbjct: 1251 LPEVGVSLDDGLAPFSPSHPAPPSDPSHQI 1280
Score = 127 bits (319), Expect = 7e-29
Identities = 134/520 (25%), Positives = 215/520 (41%), Gaps = 93/520 (17%)
Query: 469 KFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVL 528
K + LR+ GFGF ++GGDEP + + I +++ G A DG++ GD +V V+ V
Sbjct: 775 KELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVA 834
Query: 529 GHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQET 588
G TH V+ + V+L + R + EP NG+
Sbjct: 835 GKTHRYVIDLMHHAARNGQVNLTVRRK------------------VLCGGEPCPENGRSP 876
Query: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT---QPELITVH 645
HSS P S +NS+H P+ S A+ Q + +H
Sbjct: 877 GSVSTHHSS------------PRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIH 924
Query: 646 IVKGPMGFGFTIADS---PGGGG-----QRVKQIVD---SPRCRGLKEGDLIVEVNKKNV 694
K GFGF I S P G ++ +I+D + RC LK GD I+ VN +++
Sbjct: 925 R-KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSI 983
Query: 695 QALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKK---SPKSQPLERKDSQNSSQHSVSS 751
+ H +V ++ + G VTL + +P++ SP S P K S + Q ++
Sbjct: 984 INMPHADIVKLIKDA--GLSVTLRI------IPQEELNSPTSAPSSEKQSPMAQQSPLAQ 1035
Query: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK-------------KPD----PFKI 794
L A PS +T P P A+ P G + KPD PF
Sbjct: 1036 QSPL--AQPSPAT---PNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTD 1090
Query: 795 WAQSRSMYENRP----MSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIF------L 844
+ Q Y P P P + +S + + P+ DY++ F +
Sbjct: 1091 YRQPPLDYRQPPGGDYQQPPPLDYRQPPLLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDM 1150
Query: 845 WRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLV 904
+ GFGF I GG E +Y+ + G A +GR+R GD++I ++G +H
Sbjct: 1151 EKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARA 1210
Query: 905 VQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP--SPASS 942
++L++ ++ V L ++R VP+ + P SPA++
Sbjct: 1211 IELIKSGGRR--VRLLLKRG-TGQVPEYDEPAPWSSPAAA 1247
Score = 109 bits (273), Expect = 1e-23
Identities = 196/908 (21%), Positives = 333/908 (36%), Gaps = 182/908 (20%)
Query: 390 PVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR 449
P E KRK+ ++ + +++++++ + +V P H + +
Sbjct: 209 PSAEGKRKRNKSVSNMEKASIEPPEEEEEERPV---VNGNGVVVTPESSEHEDKSAGASG 265
Query: 450 EVPLQGKPF-FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAA 508
E+P Q P P ELK + TK K +EPD +
Sbjct: 266 EMPSQPYPAPVYSQPEELKEQMDDTKPTKPE--------DNEEPDPLPDNWEMAYT---- 313
Query: 509 LDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFD---PDDP 565
E G+V ++T ++ K + E C+ LP+ DDP
Sbjct: 314 -----EKGEVYFIDHNTKTTSWLDPRLAK--------KAKPPEECKENELPYGWEKIDDP 360
Query: 566 NTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP 625
+ +D +N + +++P + + + + M P + + G+
Sbjct: 361 ----IYGTYYVDH----INRRTQFENPVLEAKRKLQQHNM----PHTELGTKPLQAPGFR 408
Query: 626 NDTVSLASSIATQPELITVHIVKGPMGFGFTI--ADSPGGGGQRVKQIVDSPRCRG--LK 681
+ + + ++ + K MGFGFTI D P Q I D P + ++
Sbjct: 409 EKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKME 468
Query: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRG-GLPVPKKSPKSQP----- 735
GD+IV +N+ V TH VV + P G V L++ RG LP + P +
Sbjct: 469 TGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLA 528
Query: 736 -LERKDS-QNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQA-PDQTDSSGQKKPDPF 792
+ER + +H+ ++ + + S S + + PP + P G P
Sbjct: 529 IMERPPPVMVNGRHNYETYLE-YISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPP--- 584
Query: 793 KIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFG 852
P+ S S G + E+ + + + + GFG
Sbjct: 585 -------------PVHDDNVSMASSGATQAELMT---------------LTIVKGAQGFG 616
Query: 853 FRILGGNEPGEPIYIGHIVPLGAADTDG--RLRSGDELICVDGTPVIGKSHQLVVQLMQQ 910
F I + G+ + D G L GD ++ ++ V SH VV +++
Sbjct: 617 FTI-ADSPTGQRVK-------QILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKD 668
Query: 911 AAKQGHVNLTVRRKVVFAVPKT--------ENE---------------VPSPASSHHSS- 946
+L + R F+ KT EN+ +P P + H SS
Sbjct: 669 CPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPALHRSSF 728
Query: 947 -----------NQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
P L E+ R S+ + +S +SG +
Sbjct: 729 PDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPD-------------YK 775
Query: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1055
DV +RR E+ GFGF I+ E G P IG +I ADR G+L G
Sbjct: 776 ELDVHLRRMES-GFGFRILGG---DEPG---------QPILIGAVIAMGSADRDGRLHPG 822
Query: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGN------TVTLRIIPGDESSNATLLTNAEKIAT 1109
D ++ V+G + K+H +++L+ A TV +++ G E N +
Sbjct: 823 DELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPE----NGRSPGS 878
Query: 1110 ITTTHTP--SQQGTQETRNTTKPKQE-SQFEFKAPQATQEQDFYTVELERGAKGFGFSL- 1165
++T H+ S T N P S E A + Q D E +GFGF +
Sbjct: 879 VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKEN--EGFGFVII 936
Query: 1166 ------RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1219
G + + R+ + PA+RC K+++GD IL +NG++ NM H+ ++LIK
Sbjct: 937 SSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK 996
Query: 1220 NGGRRVRL 1227
+ G V L
Sbjct: 997 DAGLSVTL 1004
Score = 58.9 bits (141), Expect = 3e-08
Identities = 120/552 (21%), Positives = 191/552 (34%), Gaps = 103/552 (18%)
Query: 22 RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGL 81
R + G +LGG E G+ +GAV A+ +A G RL G+ L+ V G+ V+G
Sbjct: 782 RRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDG-----RLHPGDELVYVDGIPVAGK 836
Query: 82 PRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHA 141
V+ ++ A R G ++ T+R +
Sbjct: 837 THRYVIDLMHH--------AARNG----------------------QVNLTVRRKVLCGG 866
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKV 201
PC P G PG + S + TY + + P + P G
Sbjct: 867 EPC----PENGRSPGS----------VSTHHSSPRSDYATYTNSNHAAPSSNASPPEGF- 911
Query: 202 ITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADSGEQEEH 261
A HSLQ+ K + + + + + E+ VP S
Sbjct: 912 ----ASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCA 967
Query: 262 TLQ--ETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFI 319
L+ + L SII P D K + LS + P E +
Sbjct: 968 KLKVGDRILAVNGQSIINMPHAD-IVKLIKDAGLSVTLRIIPQEE--------------L 1012
Query: 320 DHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVD 379
+ T S + + QQ PL + +S + PA + ++ + Y
Sbjct: 1013 NSPTSAPS-SEKQSPMAQQSPLAQQSPLAQPSPATPNSPIAQPAPPQPLQLQGHENSYRS 1071
Query: 380 HINR----KTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
+ K P R+ L+ +Q QQ +Q PP
Sbjct: 1072 EVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYQQPPPLDYRQ-------------PP 1118
Query: 436 VIP--NHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPD 493
++ H P R+ PL R P + + + K ++GFGF++ GG E
Sbjct: 1119 LLDYRQHSPDT----RQYPLSDY----RQPQDFD--YFTVDMEKGAKGFGFSIRGGREYK 1168
Query: 494 EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELC 553
L + L DGPA +G+M GD I+ +N THA+ +++ +S G V L L
Sbjct: 1169 MDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKS--GGRRVRLLLK 1226
Query: 554 RGYPLPFDPDDP 565
RG + D+P
Sbjct: 1227 RGTGQVPEYDEP 1238
Score = 58.2 bits (139), Expect = 5e-08
Identities = 46/139 (33%), Positives = 65/139 (46%), Gaps = 13/139 (9%)
Query: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQD-----FYTVELERGAKGFGFSLRGGREYN 1172
Q T TKP Q F K P T++ F + L++ GFGF++ GG E +
Sbjct: 389 QHNMPHTELGTKPLQAPGFREK-PLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPD 447
Query: 1173 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNG--GRRVRLFLK 1230
L V + DGPA + GKM GD I+ IN H+ ++L ++ G+ V L L
Sbjct: 448 EFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLC 507
Query: 1231 RG-----DGSVPEYAMIPP 1244
RG D P +M+PP
Sbjct: 508 RGYPLPFDPEDPANSMVPP 526
Score = 50.8 bits (120), Expect = 8e-06
Identities = 57/269 (21%), Positives = 104/269 (38%), Gaps = 61/269 (22%)
Query: 1006 NEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCS 1065
N GFGF I+ E ++ +I PA + GK++ GD I+ +N
Sbjct: 433 NMGFGFTIIGGDEPDEF------------LQVKSVIPDGPAAQDGKMETGDVIVYINEVC 480
Query: 1066 ITNKSHSDIVNLIKEA--GNTVTLRI-----IPGDESSNATLLT---------------- 1102
+ +H+D+V L + G +V L + +P D A +
Sbjct: 481 VLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNG 540
Query: 1103 -------------NAEKIATITTT--HTPSQQGTQETRNTTKPK--QESQFEFKAPQATQ 1145
++ + IT H+ T + T P + + ATQ
Sbjct: 541 RHNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQ 600
Query: 1146 EQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGET 1205
+ T+ + +GA+GFGF++ +L + + C + GD I+EIN +
Sbjct: 601 AE-LMTLTIVKGAQGFGFTIADSPTGQRVKQILDI------QGCPGLCEGDLIVEINQQN 653
Query: 1206 TKNMKHSRAIELIKNG--GRRVRLFLKRG 1232
+N+ H+ ++++K+ G L + RG
Sbjct: 654 VQNLSHTEVVDILKDCPIGSETSLIIHRG 682
Score = 45.1 bits (105), Expect = 4e-04
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 13/96 (13%)
Query: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1056
+ V++ +G +GFGF I G M + R+ E PA R G+++VGD
Sbjct: 1146 FTVDMEKGA-KGFGFSIR------------GGREYKMDLYVLRLAEDGPAIRNGRMRVGD 1192
Query: 1057 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1092
+I+ +NG S + +H+ + LIK G V L + G
Sbjct: 1193 QIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRG 1228
>gi|155969695 membrane-associated guanylate kinase-related 3 isoform
2 [Homo sapiens]
Length = 1125
Score = 928 bits (2399), Expect = 0.0
Identities = 537/1290 (41%), Positives = 734/1290 (56%), Gaps = 202/1290 (15%)
Query: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
Query: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
Query: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
Query: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
Query: 235 HAENEEEDDVPEMNSSFTADSGEQ-EEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPL 293
E EE++D +N S A++ E+ E + +P N T+ S F Y +
Sbjct: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ-------TNSSMDFRNY--M 286
Query: 294 SAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED
Sbjct: 287 MRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDG------ 339
Query: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
ELP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 340 ------ELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQ----------- 382
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
E P K FTR+PS+LKG +
Sbjct: 383 -------------------------------VEIGSSKPDMEKSHFTRDPSQLKGVLVRA 411
Query: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 412 SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 472 DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGET 524
Query: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKG 649
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KG
Sbjct: 525 CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKG 584
Query: 650 PMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
P GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L +
Sbjct: 585 PKGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQF 642
Query: 710 PKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPE 769
P G++V LL+ RGG P P K+ K + + + S +++ P Q +P
Sbjct: 643 PVGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP- 689
Query: 770 FPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNF 829
FPP+ + SG K DP +++ +S+++YE++P
Sbjct: 690 FPPSIIR-------SGSPKLDPSEVYLKSKTLYEDKP----------------------- 719
Query: 830 GECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELI 889
P+ ++ D+FL ++E+GFGFR+LGG+ P + IYIG I+PLGAA+ DGRLR+ DEL+
Sbjct: 720 -----PNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELM 774
Query: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
C+DG PV GKSH+ V+ LM AA+ GHV LTVRRK+ + + E++ S + +
Sbjct: 775 CIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPR 834
Query: 950 ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 1009
+ E P +PYDV ++R ENEGF
Sbjct: 835 LNRAEVPARPAPQ--------------------------------EPYDVVLQRKENEGF 862
Query: 1010 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1069
GFVI++S ++P G +PHKIGR+IEGSPADRCGKLKVGD I AVNG SI
Sbjct: 863 GFVILTSKNKPPPG--------VIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVEL 914
Query: 1070 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK---------IATITTTHTPSQQG 1120
SH +IV LIK+AG TVTL +I +E TN+ + + H P +
Sbjct: 915 SHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
Query: 1121 TQE---TRNTTKPKQESQFEFK-------------APQATQEQDFYTVELERGAKGFGFS 1164
E ++ + + S + K + Q Y VELERG +GFGFS
Sbjct: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFS 1034
Query: 1165 LRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRR 1224
LRGG+EYNM L++LRLAEDGPA + G++ +GD+I+EINGE T+ + H+RAIELI+ GG +
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 1225 VRLFLKRGDGSVPEYAMIPPNIAACMRNEK 1254
V L L+ G G +P++ + P + + ++ E+
Sbjct: 1095 VLLLLRPGTGLIPDHGLAPSGLCSYVKPEQ 1124
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 922 bits (2384), Expect = 0.0
Identities = 535/1275 (41%), Positives = 726/1275 (56%), Gaps = 202/1275 (15%)
Query: 1 MSKVIQKKNHWTSRVHECTVK-RGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGG 59
MSK ++KK HW S+V EC V GP G+ G + GGAE GEFPY+G + PGGG
Sbjct: 1 MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREE-----PGGG 55
Query: 60 -----EGPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRH 114
G G++LLEV G VSGL D L VI +E + K V+ G +NKDLRH
Sbjct: 56 TCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRH 115
Query: 115 FLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSG 174
+L+ +FQKGS DH+LQQ IRDNLY +PCTTR+PR+GEVPGVDYNF++V++F LE+SG
Sbjct: 116 YLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESG 175
Query: 175 TLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIV 234
LLE GTY+GN+YGTPKPP++P + D + +S KRT S + M+
Sbjct: 176 ALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSS 235
Query: 235 HAENEEEDDVPEMNSSFTADSGEQ-EEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPL 293
E EE++D +N S A++ E+ E + +P N T+ S F Y +
Sbjct: 236 LPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQ-------TNSSMDFRNY--M 286
Query: 294 SAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTE 353
++ L PLP+NWEMAYT+ G +YFIDHNTKTT+WLDPR K + P E+CED
Sbjct: 287 MRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAP-EDCEDG------ 339
Query: 354 ELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQ 413
ELP GWEKIEDP YG YYVDH+N+KTQ+ENPV EAKRKKQL Q
Sbjct: 340 ------ELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQ----------- 382
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHT 473
E P K FTR+PS+LKG +
Sbjct: 383 -------------------------------VEIGSSKPDMEKSHFTRDPSQLKGVLVRA 411
Query: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
L+KS+ GFGFT++GGD PDEFLQ+K+++ DGPAA DGK+ GDVIV +N CVLGHTHA
Sbjct: 412 SLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
VV++FQ +P+ V+L LCRGYPLP D +DP +V + ++NGQ
Sbjct: 472 DVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATP-------VINGQSLTKGET 524
Query: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDT----VSLASSIATQPELITVHIVKG 649
+ + K M + + P+D VS+ASS ++QPEL+T+ ++KG
Sbjct: 525 CMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKG 584
Query: 650 PMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVEC 709
P GFGF IADSP GQ+VK I+DS C+GL++GD+I E+ +NVQ LTH QVV++L +
Sbjct: 585 PKGFGFAIADSP--TGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQF 642
Query: 710 PKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPE 769
P G++V LL+ RGG P P K+ K + + + S +++ P Q +P
Sbjct: 643 PVGADVPLLILRGGPPSPTKTAK--------MKTDKKENAGSLEAINEPIP----QPMP- 689
Query: 770 FPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNF 829
FPP+ + SG K DP +++ +S+++YE++P
Sbjct: 690 FPPSIIR-------SGSPKLDPSEVYLKSKTLYEDKP----------------------- 719
Query: 830 GECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELI 889
P+ ++ D+FL ++E+GFGFR+LGG+ P + IYIG I+PLGAA+ DGRLR+ DEL+
Sbjct: 720 -----PNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELM 774
Query: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
C+DG PV GKSH+ V+ LM AA+ GHV LTVRRK+ + + E++ S + +
Sbjct: 775 CIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPR 834
Query: 950 ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 1009
+ E P +PYDV ++R ENEGF
Sbjct: 835 LNRAEVPARPAPQ--------------------------------EPYDVVLQRKENEGF 862
Query: 1010 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1069
GFVI++S ++P G +PHKIGR+IEGSPADRCGKLKVGD I AVNG SI
Sbjct: 863 GFVILTSKNKPPPG--------VIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVEL 914
Query: 1070 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK---------IATITTTHTPSQQG 1120
SH +IV LIK+AG TVTL +I +E TN+ + + H P +
Sbjct: 915 SHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRS 974
Query: 1121 TQE---TRNTTKPKQESQFEFK-------------APQATQEQDFYTVELERGAKGFGFS 1164
E ++ + + S + K + Q Y VELERG +GFGFS
Sbjct: 975 ALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFS 1034
Query: 1165 LRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRR 1224
LRGG+EYNM L++LRLAEDGPA + G++ +GD+I+EINGE T+ + H+RAIELI+ GG +
Sbjct: 1035 LRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNK 1094
Query: 1225 VRLFLKRGDGSVPEY 1239
V L L+ G G +P++
Sbjct: 1095 VLLLLRPGTGLIPDH 1109
Score = 99.8 bits (247), Expect = 2e-20
Identities = 126/535 (23%), Positives = 210/535 (39%), Gaps = 88/535 (16%)
Query: 434 PPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPD 493
PP I +P+ EV L+ K + P K + LRK GFGF V+GGD PD
Sbjct: 691 PPSIIRSGSPKLDPS-EVYLKSKTLYEDKPPNTKD--LDVFLRKQESGFGFRVLGGDGPD 747
Query: 494 EFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELC 553
+ + I +++ G A DG++ D ++ ++ V G +H QV+ + + V L +
Sbjct: 748 QSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVR 807
Query: 554 RGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
R + +K+P + Q + S + S + + P P
Sbjct: 808 R-----------------KIFYGEKQPEDDSSQ-AFISTQNGSPRLNRAEVPARPAPQEP 849
Query: 614 ADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVD 673
DV V L S P +I P G I SP
Sbjct: 850 YDVVLQRKENEGFGFVILTSKNKPPPGVI-------PHKIGRVIEGSP------------ 890
Query: 674 SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKS 733
+ RC LK GD I VN +++ L+H+ +V ++ + G VTL V + ++
Sbjct: 891 ADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDA--GVTVTLTV------IAEEEHHG 942
Query: 734 QPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFK 793
P + ++ Q HR + + +H +P D++ G+ D
Sbjct: 943 PP---SGTNSARQSPALQHRPMGQSQANH----IPG---------DRSALEGEIGKDVST 986
Query: 794 IWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGF 853
+ S S +++ P A G R + N G P+ L R GFGF
Sbjct: 987 SYRHSWSDHKHLAQ-PDTAVISVVGSRHNQ----NLGCYPVE--------LERGPRGFGF 1033
Query: 854 RILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
+ GG E ++I + G A DGR+ GD+++ ++G P G +H ++L+Q
Sbjct: 1034 SLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGN 1093
Query: 914 QGHVNLTVRRKVVFAVPKTENEVPSPASSH---------HSSNQPASLTEEKRTP 959
+ V L +R + ++ +P+SS+ S+ AS+ EE P
Sbjct: 1094 K--VLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVP 1146
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 127 bits (319), Expect = 7e-29
Identities = 192/865 (22%), Positives = 345/865 (39%), Gaps = 128/865 (14%)
Query: 414 QQQQQQQQTEEWTEDH-------SALVPPVIPNHPPSNPEPARE---VPLQGKPFFTRNP 463
+QQ + + T WTE H SA +P V+P+ E E + + +N
Sbjct: 941 EQQYECENTIVWTESHLPSEVISSAELPSVLPDSAGKGSEYLLEQSSLACNAECVMLQNV 1000
Query: 464 SELKGKFIHT-KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSV 522
S K F T + K + G TV + + ++S++ G + DG++ GD I+S+
Sbjct: 1001 S--KESFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSI 1057
Query: 523 NDTCVLGHTHAQVVKIFQSIP-IGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPI 581
N+ + T+AQ + + IG + + P L L ++
Sbjct: 1058 NEESTISVTNAQARAMLRRHSLIGPDIKITYV-----------PAEHLEEFKISLGQQSG 1106
Query: 582 IVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPEL 641
V + + SS TG+ R + + + Y N + +P
Sbjct: 1107 RVMALDIF------SSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPSK 1160
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSPRCRG--LKEGDLIVEVNKKNVQALT 698
+ G G G +++ G +K ++ DSP + LK GD IVEV+ +++ +
Sbjct: 1161 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDAS 1220
Query: 699 HNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTA 758
H Q V+ + + G+ V +VQ + P+KSP L H++ + +
Sbjct: 1221 HEQAVEAIRKA--GNPVVFMVQ-SIINRPRKSPLPSLL----------HNLYPKYNFSST 1267
Query: 759 SP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSK 817
+P + S Q+ + P+++++ + P P +A+ S + + S AS +S+
Sbjct: 1268 NPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDH-----TQSSASKISQ 1322
Query: 818 G-----------EREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGE-PI 865
+ RE T GE + I L + +G G + G + +
Sbjct: 1323 DVDKEDEFGYSWKNIRERYGTLTGELHM-------IELEKGHSGLGLSLAGNKDRSRMSV 1375
Query: 866 YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 925
+I I P GAA DGRL+ DEL+ ++G + G+SHQ +++ A + + +
Sbjct: 1376 FIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDA 1435
Query: 926 V--FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGG 983
V AV P P++S + N+ TE T + L++ + GG
Sbjct: 1436 VNQMAVCPGNAVEPLPSNSENLQNKE---TEPTVTTSDAAVDLSSFKNVQHLELPKDQGG 1492
Query: 984 GGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEG 1043
G I E + VI+ S++ E
Sbjct: 1493 LG---------------IAISEEDTLSGVIIKSLT-----------------------EH 1514
Query: 1044 SPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI---------IPGDE 1094
A G+LKVGD+ILAV+ + ++L+K A TV L I +P
Sbjct: 1515 GVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAENPDSQAVPSAA 1574
Query: 1095 SSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL 1154
+ + N+ + + + +P + + T ++ P + P + T+E+
Sbjct: 1575 GAASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCET--TIEI 1632
Query: 1155 ERGAKGFGFSLRGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSR 1213
+G G G S+ GG + + ++ + E+G A + G++ GD+ILE+NG + H
Sbjct: 1633 SKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDE 1692
Query: 1214 AIELIKNGGRRVRLFLKRGDGSVPE 1238
AI +++ +RVRL L R + E
Sbjct: 1693 AINVLRQTPQRVRLTLYRDEAPYKE 1717
Score = 102 bits (255), Expect = 2e-21
Identities = 117/527 (22%), Positives = 208/527 (39%), Gaps = 88/527 (16%)
Query: 755 LHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASG 814
L TA + + E P ++A +SG+KK S+S+ + SP P S
Sbjct: 1549 LKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNS-------SQSLMVPQSGSPEPESI 1601
Query: 815 LSKGERERE-INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPG-EPIYIGHIVP 872
+ I +++ CPI E I + + TG G I+GG++ I I +
Sbjct: 1602 RNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYE 1661
Query: 873 LGAADTDGRLRSGDELICVDGTPVIGKSHQ------------------------------ 902
GAA DGRL +GD+++ V+G + +H
Sbjct: 1662 EGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVC 1721
Query: 903 --LVVQLMQQAAKQGHVNLTVRRKV--VFAVPKTENEVPSPASSHHSSNQPASLTEEK-- 956
L ++L ++ K +++ +R VF + + +Q + E
Sbjct: 1722 DTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVR 1781
Query: 957 -----------RTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGE 1005
+ +GS +S SGS ++ + S + + S + VE+++G
Sbjct: 1782 NATQEAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNA-LASEIQGLRTVEMKKGP 1840
Query: 1006 NEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCS 1065
+ G I V P +AM H G A + KL+VGDRI+ + G S
Sbjct: 1841 TDSLGISIAGGVGSPLGDVPI---FIAMMHPTG------VAAQTQKLRVGDRIVTICGTS 1891
Query: 1066 ITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR 1125
+H+ VNL+K A ++ ++++ G + S + T H + +
Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQVVAGGDVS-------------VVTGHQQEPASSSLSF 1938
Query: 1126 NTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG---REYNMDLYVLRLAE 1182
Q + PQ ++ LERG G GFS+ GG ++ +YV +
Sbjct: 1939 TGLTSSSIFQDDLGPPQCK------SITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFA 1992
Query: 1183 DGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1229
G A G+++ GD+I+ +NG++ + + H A+ ++K V L +
Sbjct: 1993 KGAASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039
Score = 99.8 bits (247), Expect = 2e-20
Identities = 152/668 (22%), Positives = 274/668 (41%), Gaps = 99/668 (14%)
Query: 631 LASSIATQPELITVHIVKGPMG-FGFTI----ADSPGGGGQRVKQIVDSP---RCRGLKE 682
L ++A + ++K P G GF++ +++ G G V++I + R LKE
Sbjct: 125 LIKNMAQGRHVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKE 184
Query: 683 GDLIVEVNKKNV-QALTHNQVVDMLVECPKGSEVTLLVQRGGL-----PVPKKSPK---- 732
D I+ +N + + Q +TH Q + +L + V L++ RG L P+ +SP
Sbjct: 185 TDQILAINGQALDQTITHQQAISILQKAK--DTVQLVIARGSLPQLVSPIVSRSPSAAST 242
Query: 733 ----SQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPD--------- 779
S P+ + + + S + ++ P
Sbjct: 243 ISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVIVKTILPGGVADQHGRLCSGDHI 302
Query: 780 ----QTDSSGQKKPDPFKIWAQ---------SRSMYENRPMSPSPASGLSKGERE----R 822
TD +G ++ Q +R E R + LS R
Sbjct: 303 LKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARGAIEERTAPTALGITLSSSPTSTPELR 362
Query: 823 EINSTNFGECPIPDYQEQDIFLWRKETGFGFRILG--GNEPGEP--IYIGHIVPLGAADT 878
ST GE + + D+ L + G G I G G++ EP I++ I A +
Sbjct: 363 VDASTQKGE----ESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEH 418
Query: 879 DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPS 938
DGR++ GD++I VDGT + G ++Q V++++ + V LT+ R+ + K E E+ S
Sbjct: 419 DGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQT--VLLTLMRRGM----KQEAELMS 472
Query: 939 PASSHHSSN-QPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPY 997
++ P + + K + ++ L S + +T+ + + G + + + +
Sbjct: 473 REDVTKDADLSPVNASIIKENYEKDEDFL----SSTRNTNILPTEEEGYPLLSAEIEEIE 528
Query: 998 DVEIRRG-------ENEGFGF-VIVSSVSRPEAGTTFGNACVAMP--HKIGRIIEGSPAD 1047
D + + G + ++V+ VS+ + G + A H I ++ P
Sbjct: 529 DAQKQEAALLTKWQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVG 588
Query: 1048 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTL----RIIPGDESSNATLLTN 1103
GKL GD +L VNG ++ ++H D+VN++KE VT+ R +P S L
Sbjct: 589 HSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMVCCRRTVPPTTQSELDSL-- 646
Query: 1104 AEKIATITTTHTPSQQ-----GTQETRN---TTKPKQESQFEFKAPQATQEQDFYTVELE 1155
+ I T P G+ ET + +S E +AP A E +ELE
Sbjct: 647 --DLCDIELTEKPHVDLGEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELE 704
Query: 1156 RGAKGFGFSLRGGRE----YNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
+G+KG GFS+ ++ + + + L G AE+ G++ GD ++ +N +N
Sbjct: 705 KGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSL 764
Query: 1212 SRAIELIK 1219
A+E +K
Sbjct: 765 EEAVEALK 772
Score = 95.5 bits (236), Expect = 3e-19
Identities = 109/469 (23%), Positives = 190/469 (40%), Gaps = 91/469 (19%)
Query: 839 EQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIG 898
E+ I + + + G + N+ G + + I+ GA DGR+ GD ++ ++ I
Sbjct: 1006 ERTINIAKGNSSLGMTV-SANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTIS 1064
Query: 899 KSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRT 958
V +A + H + K+ + PA EE +
Sbjct: 1065 -----VTNAQARAMLRRHSLIGPDIKITYV--------------------PAEHLEEFKI 1099
Query: 959 PQGSQN----SLNTVSSGSGST--------SGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006
G Q+ +L+ SS +G G G + S QP VE+ R +
Sbjct: 1100 SLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEESELQNTAYSNWNQPRRVELWREPS 1159
Query: 1007 EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSI 1066
+ G IV G+ N V I ++E SPA + G LK GDRI+ V+G +
Sbjct: 1160 KSLGISIVGGRGM---GSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216
Query: 1067 TNKSHSDIVNLIKEAGNTVTLRI-----------IPG----------DESSNA---TLLT 1102
+ SH V I++AGN V + +P S+N +L
Sbjct: 1217 RDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQI 1276
Query: 1103 NAEKI----------ATITTTHTP-----SQQGTQETRNTTKP-----KQESQFEF---- 1138
NA+K A + + P ++ G+ T+++ +E +F +
Sbjct: 1277 NADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKN 1336
Query: 1139 -KAPQATQEQDFYTVELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAERCGKMRIGD 1196
+ T + + +ELE+G G G SL G ++ + M ++++ + +G A + G+++I D
Sbjct: 1337 IRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIAD 1396
Query: 1197 EILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPN 1245
E+LEING+ H A +IK +V++ R +V + A+ P N
Sbjct: 1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQMAVCPGN 1445
Score = 95.1 bits (235), Expect = 4e-19
Identities = 143/645 (22%), Positives = 248/645 (38%), Gaps = 113/645 (17%)
Query: 472 HTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHT 531
H +L K G G + D + IKSL G AA DG+++ GD I++V+D V+G+
Sbjct: 1483 HLELPKDQGGLGIAISEEDTLSGVI-IKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYP 1541
Query: 532 HAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS 591
+ + + ++ + + + +PD A +K+ N ++
Sbjct: 1542 IEKFISLLKTAKMTVKLTIHA-------ENPDSQAVPSAAGAASGEKK----NSSQSLMV 1590
Query: 592 PASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPM 651
P S S + + +R S+PA AS+ + T + T T+ I KG
Sbjct: 1591 PQSGSPEPESIRNT--SRSSTPAIFASDPA------TCPIIPGCET-----TIEISKGRT 1637
Query: 652 GFGFTIADSPGGGGQRVKQIV------DSPRCRG--LKEGDLIVEVNKKNVQALTHNQVV 703
G G +I GG + I+ + C+ L GD I+EVN +++ TH++ +
Sbjct: 1638 GLGLSIV---GGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAI 1694
Query: 704 DMLVECPKGSEVTLLVQRGG-----------LPVPKKSPKSQPLERKDSQNSSQHSVSSH 752
++L + P+ +TL + + KK K L +N + VS
Sbjct: 1695 NVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDI 1754
Query: 753 RSLHTASPS----HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMS 808
A Q+L D +++ + K+ S S +
Sbjct: 1755 VKGGIADADGRLMQGDQILM------VNGEDVRNATQEAVAALLKVSEGSLSSFT----- 1803
Query: 809 PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG--NEPGE-PI 865
P SG S E + N I + ++ ++ G I GG + G+ PI
Sbjct: 1804 -FPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDS-LGISIAGGVGSPLGDVPI 1861
Query: 866 YIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV 925
+I + P G A +LR GD ++ + GT G +H V L++ A+ ++ +V
Sbjct: 1862 FIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASG------SIEMQV 1915
Query: 926 VFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGG 985
V + + +T ++ P S S ++S S +G
Sbjct: 1916 V------------------AGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGPP--- 1954
Query: 986 GSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSP 1045
Q + + RG +G GF IV P +P + +
Sbjct: 1955 ---------QCKSITLERGP-DGLGFSIVGGYGSPHGD---------LPIYVKTVFAKGA 1995
Query: 1046 ADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1090
A G+LK GD+I+AVNG S+ +H + V ++K TVTL ++
Sbjct: 1996 ASEDGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 78.6 bits (192), Expect = 4e-14
Identities = 87/393 (22%), Positives = 159/393 (40%), Gaps = 89/393 (22%)
Query: 850 GFGFRILG--GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 905
G GF ++G GE I++ I A DGRL+ D+++ ++G + +HQ +
Sbjct: 147 GLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAINGQALDQTITHQQAI 206
Query: 906 QLMQQAAKQGHVNLTVRR-KVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQN 964
++Q+A + V L + R + V + PS AS+ + + P
Sbjct: 207 SILQKA--KDTVQLVIARGSLPQLVSPIVSRSPSAASTISAHSNPVHWQH--------ME 256
Query: 965 SLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 1024
++ V+ GSG G G GG +GV+ + P
Sbjct: 257 TIELVNDGSGL--GFGIIGGKATGVIVKTILP---------------------------- 286
Query: 1025 TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084
G AD+ G+L GD IL + + S + ++++ GN
Sbjct: 287 ------------------GGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNR 328
Query: 1085 VTLRIIPG--DESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQ 1142
V L I G +E + T L IT + +P+ T E R + Q
Sbjct: 329 VKLMIARGAIEERTAPTALG-------ITLSSSPTS--TPELRVDA-----------STQ 368
Query: 1143 ATQEQDFYTVELERGAKGFGFSLRG----GREYNMDLYVLRLAEDGPAERCGKMRIGDEI 1198
+E + + VEL + +G G ++ G + ++V + + E G+++IGD+I
Sbjct: 369 KGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQI 428
Query: 1199 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+ ++G + + +A+E++++ G+ V L L R
Sbjct: 429 IAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMR 461
Score = 77.8 bits (190), Expect = 6e-14
Identities = 111/498 (22%), Positives = 197/498 (39%), Gaps = 95/498 (19%)
Query: 809 PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIG 868
PS + L E E + +++ Q + L + + G G I + + I
Sbjct: 1451 PSNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSGVIIK 1509
Query: 869 HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFA 928
+ G A TDGRL+ GD+++ VD V+G + + L++ A +TV+ +
Sbjct: 1510 SLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTA------KMTVKLTIHAE 1563
Query: 929 VPKTENEVPSPASSHHSSNQPASLTEEKRTPQ-GSQNSLNTVSSGSGSTSGIGSGGGGGS 987
P ++ VPS A + +S + + ++ PQ GS + ++ ST I +
Sbjct: 1564 NPDSQ-AVPSAAGA--ASGEKKNSSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATC 1620
Query: 988 GVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPAD 1047
++ +EI +G G G IV T A + I + E A
Sbjct: 1621 PIIPGCETT--IEISKGRT-GLGLSIVGG------SDTLLGAII-----IHEVYEEGAAC 1666
Query: 1048 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIK--------------------EAGNTVTL 1087
+ G+L GD+IL VNG + +H + +N+++ E +T+T+
Sbjct: 1667 KDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTLTI 1726
Query: 1088 RI-----------IPGDESSNATLLTNAEKIATITTTHTPSQQGTQ-------ETRNTTK 1129
+ I G + +++ K I QG Q + RN T+
Sbjct: 1727 ELQKKPGKGLGLSIVGKRNDTGVFVSDIVK-GGIADADGRLMQGDQILMVNGEDVRNATQ 1785
Query: 1130 PKQE----------SQFEF----------------KAPQATQEQDFYTVELERG-AKGFG 1162
S F F K A++ Q TVE+++G G
Sbjct: 1786 EAVAALLKVSEGSLSSFTFPLSGSSTSESLESSSKKNALASEIQGLRTVEMKKGPTDSLG 1845
Query: 1163 FSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1219
S+ GG ++ +++ + G A + K+R+GD I+ I G +T+ M H++A+ L+K
Sbjct: 1846 ISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLK 1905
Query: 1220 NGGRRVRL-FLKRGDGSV 1236
N + + + GD SV
Sbjct: 1906 NASGSIEMQVVAGGDVSV 1923
Score = 72.8 bits (177), Expect = 2e-12
Identities = 134/658 (20%), Positives = 237/658 (36%), Gaps = 129/658 (19%)
Query: 643 TVHIVKGPMGFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTH 699
T++I KG G T++ + G G V+ I+ R + GD I+ +N+++ ++T+
Sbjct: 1008 TINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVTN 1067
Query: 700 NQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTAS 759
Q ML +R L P P E + S S
Sbjct: 1068 AQARAML-------------RRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIF 1114
Query: 760 PSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLS-KG 818
S++ + +PE P E ++++ + W Q R + R PS + G+S G
Sbjct: 1115 SSYTGRDIPELPEREEGEGEESELQNTA----YSNWNQPRRVELWR--EPSKSLGISIVG 1168
Query: 819 EREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADT 878
R G G R+ G E I+I H++ A
Sbjct: 1169 GR-----------------------------GMGSRLSNG-EVMRGIFIKHVLEDSPAGK 1198
Query: 879 DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN---E 935
+G L+ GD ++ VDG + SH+ V+ +++A VVF V N +
Sbjct: 1199 NGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNP----------VVFMVQSIINRPRK 1248
Query: 936 VPSPASSHH-------SSNQP--------------ASLTEEKRTPQGS------------ 962
P P+ H+ SS P S +E ++ P S
Sbjct: 1249 SPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEM 1308
Query: 963 -----QNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV-QPYDVEIRRGENEGFGFVIVSS 1016
Q+S + +S G T+ + + +E+ +G + G G + +
Sbjct: 1309 GSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS-GLGLSLAGN 1367
Query: 1017 VSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVN 1076
R M I I A + G+L++ D +L +NG + +SH + +
Sbjct: 1368 KDRSR-----------MSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGRSHQNASS 1416
Query: 1077 LIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQF 1136
+IK A + V + I ++ N + + + + Q E TT
Sbjct: 1417 IIKCAPSKVKIIFIRNKDAVNQMAVCPGNAVEPLPSNSENLQNKETEPTVTTSDAAVDLS 1476
Query: 1137 EFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGD 1196
FK Q +EL + G G ++ + + + L E G A G++++GD
Sbjct: 1477 SFKNVQ--------HLELPKDQGGLGIAI-SEEDTLSGVIIKSLTEHGVAATDGRLKVGD 1527
Query: 1197 EILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEK 1254
+IL ++ E + I L+K V+L + + P+ +P A +K
Sbjct: 1528 QILAVDDEIVVGYPIEKFISLLKTAKMTVKLTIHAEN---PDSQAVPSAAGAASGEKK 1582
Score = 72.4 bits (176), Expect = 3e-12
Identities = 140/662 (21%), Positives = 249/662 (37%), Gaps = 143/662 (21%)
Query: 451 VPLQGKPFFTRNPSELKGKFIHT-----------KLRKSSRGFGFTVVGGDEPDEFLQIK 499
+P P +R+PS H+ +L G GF ++GG +K
Sbjct: 225 LPQLVSPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATGVI--VK 282
Query: 500 SLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559
+++ G A G++ +GD I+ + DT + G + QV ++ + G V L + RG
Sbjct: 283 TILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQC--GNRVKLMIARG---- 336
Query: 560 FDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASN 619
AI ++ P++ S+
Sbjct: 337 --------------AIEER-----------------------------TAPTALGITLSS 353
Query: 620 SSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGG-----GGQRVKQIVDS 674
S P V ++ + E V + K G G TIA G G VK I S
Sbjct: 354 SPTSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKS 413
Query: 675 PRCRG---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSP 731
++ GD I+ V+ N+Q T+ Q V++L G V L + R G+ +
Sbjct: 414 SAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRH--TGQTVLLTLMRRGMKQEAELM 471
Query: 732 KSQPLERKDSQ----NSSQHSVSSHRSLHTASPSHSTQVLPE----FPPAEAQAPDQTDS 783
+ + KD+ N+S + + S + +T +LP +P A+ + D+
Sbjct: 472 SREDV-TKDADLSPVNASIIKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDA 530
Query: 784 SGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIF 843
Q+ A+ L+K +R IN + +
Sbjct: 531 QKQE------------------------AALLTKWQRIMGINY---------EIVVAHVS 557
Query: 844 LWRKETGFGFRI---LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS 900
+ + +G G + +G + +I ++P G G+L SGDEL+ V+G ++G++
Sbjct: 558 KFSENSGLGISLEATVGHH------FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGEN 611
Query: 901 HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ 960
HQ VV ++++ + V + R+ V P T++E+ S LTE+
Sbjct: 612 HQDVVNILKELPIE--VTMVCCRRTV--PPTTQSELDS------LDLCDIELTEKPHVDL 661
Query: 961 GS-QNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSR 1019
G S T T S + + +E+ +G ++G GF I+
Sbjct: 662 GEFIGSSETEDPVLAMTDAGQSTEEVQAPLAMWEAGIQHIELEKG-SKGLGFSILDYQDP 720
Query: 1020 PEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK 1079
+ +T I ++ G A++ G+L GDR++ VN ++ N S + V +K
Sbjct: 721 IDPASTV--------IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALK 772
Query: 1080 EA 1081
A
Sbjct: 773 GA 774
Score = 66.6 bits (161), Expect = 1e-10
Identities = 59/236 (25%), Positives = 103/236 (43%), Gaps = 41/236 (17%)
Query: 1000 EIRRGENEGFGFVIVS--SVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
E+ + + G GF +V S +R E G + I EGS A R G+LK D+
Sbjct: 139 ELLKPPSGGLGFSVVGLRSENRGELGIF-----------VQEIQEGSVAHRDGRLKETDQ 187
Query: 1058 ILAVNGCSITNK-SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1116
ILA+NG ++ +H ++++++A +TV L I G + ++ + + +P
Sbjct: 188 ILAINGQALDQTITHQQAISILQKAKDTVQLVIARG----------SLPQLVSPIVSRSP 237
Query: 1117 SQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1176
S T + Q + T+EL G GF + GG+ +
Sbjct: 238 SAASTISAHSNPVHWQHME---------------TIELVNDGSGLGFGIIGGKATGV--I 280
Query: 1177 VLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1232
V + G A++ G++ GD IL+I M + ++++ G RV+L + RG
Sbjct: 281 VKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMIARG 336
Score = 56.2 bits (134), Expect = 2e-07
Identities = 104/479 (21%), Positives = 181/479 (37%), Gaps = 101/479 (21%)
Query: 474 KLRKSSRGFGFTVVG--GDEPDE--FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
+L K+ +G G T+ G GD+ E + +KS+ DG+++ GD I++V+ T + G
Sbjct: 379 ELTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQG 438
Query: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVN-GQET 588
T+ Q V++ + G +V L L R + + + + VT A D P+ + +E
Sbjct: 439 FTNQQAVEVLRH--TGQTVLLTLMR-RGMKQEAELMSREDVTKDA--DLSPVNASIIKEN 493
Query: 589 YDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYP---------NDTVSLASSIATQ- 638
Y+ S T N + GYP D +++ T+
Sbjct: 494 YEKDEDFLSSTRNTN------------ILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKW 541
Query: 639 -------PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVE 688
E++ H+ K G I+ G ++ ++ + P L GD ++E
Sbjct: 542 QRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLE 601
Query: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHS 748
VN + H VV++L E P EVT++ R +P P + L+ D + + +
Sbjct: 602 VNGITLLGENHQDVVNILKELP--IEVTMVCCRRTVP-PTTQSELDSLDLCDIELTEKPH 658
Query: 749 VSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMS 808
V + ++ + + S ++ P +W E
Sbjct: 659 VDLGEFIGSSETEDPVLAMTD-----------AGQSTEEVQAPLAMWEAGIQHIE----- 702
Query: 809 PSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEP---- 864
L KG + G GF IL +P +P
Sbjct: 703 ------LEKGSK-----------------------------GLGFSILDYQDPIDPASTV 727
Query: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRR 923
I I +VP G A+ DGRL GD L+ V+ + S + V+ + + A G V + V +
Sbjct: 728 IIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEAL-KGAPSGTVRIGVAK 785
Score = 48.1 bits (113), Expect = 5e-05
Identities = 60/264 (22%), Positives = 108/264 (40%), Gaps = 45/264 (17%)
Query: 498 IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557
I+S++ +GP GK+ +GD ++ VN +LG H VV I + +PI V + CR
Sbjct: 578 IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPI--EVTMVCCRRTV 635
Query: 558 LPFDPDDPNTSLVTSVAILDKEPI----IVNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
P + ++ + + + +K + + ET D V M DA S
Sbjct: 636 PPTTQSELDSLDLCDIELTEKPHVDLGEFIGSSETED----------PVLAMTDAGQS-- 683
Query: 614 ADVASNSSHGYPNDTVSLASSIAT-QPELITVHIVKGPMGFGFTIAD-----SPGGGGQR 667
T + + +A + + + + KG G GF+I D P
Sbjct: 684 --------------TEEVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVII 729
Query: 668 VKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
++ +V + + L GD ++ VN N++ + + V+ L P G+ V + V +
Sbjct: 730 IRSLVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGT-VRIGVAK--- 785
Query: 725 PVPKKSPKSQPLERKDSQNSSQHS 748
P+P + ++DS HS
Sbjct: 786 PLPLSPEEGYVSAKEDSFLYPPHS 809
Score = 45.8 bits (107), Expect = 3e-04
Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 7/97 (7%)
Query: 472 HTKLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
H +L K S+G GF+++ +P + + I+SLV G A DG++ GD ++ VND +
Sbjct: 700 HIELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNL 759
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDD 564
+ + V+ + P G + + PLP P++
Sbjct: 760 ENSSLEEAVEALKGAPSGT---VRIGVAKPLPLSPEE 793
Score = 43.9 bits (102), Expect = 0.001
Identities = 62/266 (23%), Positives = 105/266 (39%), Gaps = 62/266 (23%)
Query: 464 SELKGKFIHTKLRKSSRGFGFTVVGG-DEP--DEFLQIKSLVLDGPAALDGKMETGDVIV 520
SE++G + + G ++ GG P D + I + G AA K+ GD IV
Sbjct: 1826 SEIQGLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIV 1885
Query: 521 SVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP 580
++ T G TH Q V + ++ S+++++ G + S+VT
Sbjct: 1886 TICGTSTEGMTHTQAVNLLKN--ASGSIEMQVVAG---------GDVSVVTG-------- 1926
Query: 581 IIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPE 640
+ QE S S + T D P P+
Sbjct: 1927 ---HQQEPASSSLSFTGLTSSSIFQDDLGP----------------------------PQ 1955
Query: 641 LITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG-------LKEGDLIVEVNKKN 693
++ + +GP G GF+I G + V + +G LK GD I+ VN ++
Sbjct: 1956 CKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQS 2015
Query: 694 VQALTHNQVVDMLVECPKGSEVTLLV 719
++ +TH + V +L + KG+ VTL+V
Sbjct: 2016 LEGVTHEEAVAIL-KRTKGT-VTLMV 2039
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 113 bits (283), Expect = 1e-24
Identities = 194/835 (23%), Positives = 301/835 (36%), Gaps = 158/835 (18%)
Query: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
D D I S+V GP G ++ D ++ VN + G + + V + +P
Sbjct: 575 DSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVP------ 628
Query: 550 LELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDS-PASHSSKTGKVNGMKDA 608
P +LV + D E + + T S P + VN +D
Sbjct: 629 ---------------PPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEED- 672
Query: 609 RPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIAD-----SPGG 663
D LA PE+ V +VK G GF+I D P
Sbjct: 673 ------------------DDGELA---LWSPEVKIVELVKDCKGLGFSILDYQDPLDPTR 711
Query: 664 GGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
++ +V + R GL GD +V VN+ + + + V++L P G LV
Sbjct: 712 SVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDNTSLAEAVEILKAVPPG-----LVH 766
Query: 721 RGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSLHTASPSH--STQVLPEFPPAEAQ 776
G +PL + + S HS S+ + H ++ ++ E P
Sbjct: 767 LG---------ICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKGFRD 817
Query: 777 AP----DQTDSS----GQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREI---- 824
P + D G+ K QS+ +E M L + + ERE+
Sbjct: 818 EPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWE---MHEFLTPRLQEMDEEREMLVDE 874
Query: 825 -------NSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEP--------GEPIYIGH 869
S + P+ QE E FG + L NEP G +Y
Sbjct: 875 EYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLHDNEPSESQEARTGRTVYSQE 934
Query: 870 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAV 929
P G + E ++ P + + QQ NL K +
Sbjct: 935 AQPYGYCPENVM----KENFVMESLPSVPSTEGN----SQQGRFDDLENLNSLAKTSLDL 986
Query: 930 PKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGS-------- 981
N+V P S A E++ P + +S S T + S
Sbjct: 987 GMIPNDVQGP-SLLIDLPVVAQRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCE 1045
Query: 982 ------GGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSS---VSRPEAGTTFGNACVA 1032
G G + S P VEI R N G IV + R + G +
Sbjct: 1046 LPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIK 1105
Query: 1033 MPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPG 1092
+++E SPA + LK GD+IL V+G + N SHS+ V IK AGN V I
Sbjct: 1106 ------QVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVF--IVQ 1157
Query: 1093 DESSNATLLTNAEKIATITT--THTPSQQGTQETRNTTKPKQESQFEFKA----PQATQE 1146
SS ++ N A T + +Q+ ++ + T P + +KA +E
Sbjct: 1158 SLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEE 1217
Query: 1147 QDFYT-----------------VELERGAKGFGFSLRGGREYN-MDLYVLRLAEDGPAER 1188
+D +T +ELE+ G G SL G ++ + M ++V+ + +GPA
Sbjct: 1218 EDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAA 1277
Query: 1189 CGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIP 1243
G+MRIGDE+LEIN + H A +IK +V+L R + +V + A+ P
Sbjct: 1278 DGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTP 1332
Score = 93.6 bits (231), Expect = 1e-18
Identities = 110/450 (24%), Positives = 189/450 (42%), Gaps = 94/450 (20%)
Query: 816 SKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGA 875
+K +N T E + E+ + L +G GF I+GG G + + IVP G
Sbjct: 224 TKSSTSSSLNDTTLPETVCWGHVEE-VELINDGSGLGFGIVGGKTSG--VVVRTIVPGGL 280
Query: 876 ADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 935
AD DGRL++GD ++ + GT V G + + V Q+++ V + V R P +
Sbjct: 281 ADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNS--VRMLVARD-----PAGDIS 333
Query: 936 VPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
V PA PA+L +L TV+S G G S++ +
Sbjct: 334 VTPPA--------PAALPV----------ALPTVASK-------------GPGSDSSLFE 362
Query: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1055
Y+VE+ R + + G IV V G G + II GS A G ++V
Sbjct: 363 TYNVELVRKDGQSLGIRIVGYVGTSHTGEASGIY-------VKSIIPGSAAYHNGHIQVN 415
Query: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN------------------ 1097
D+I+AV+G +I ++ D+V +++ AG V L ++ SS+
Sbjct: 416 DKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTVVEPLK 475
Query: 1098 --ATLLTNA---------------EKIATITTTHTPSQQGTQETRNTTKPKQESQFE--- 1137
A LT A E+I T+ + + + ++ ++ + + +S++E
Sbjct: 476 PPALFLTGAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDSPENELKSRWENLL 535
Query: 1138 ---FKAPQATQE-QDFYTVELERGAKGFGF-SLRGGRE---YNMDLYVLRLAEDGPAERC 1189
++ AT + Q EL++ +K +LR G E ++ Y+ + GP +
Sbjct: 536 GPDYEVMVATLDTQIADDAELQKYSKLLPIHTLRLGVEVDSFDGHHYISSIVSGGPVDTL 595
Query: 1190 GKMRIGDEILEINGETTKNMKHSRAIELIK 1219
G ++ DE+LE+NG A+ +K
Sbjct: 596 GLLQPEDELLEVNGMQLYGKSRREAVSFLK 625
Score = 89.4 bits (220), Expect = 2e-17
Identities = 138/611 (22%), Positives = 228/611 (37%), Gaps = 148/611 (24%)
Query: 668 VKQIV-DSP--RCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGL 724
+KQ++ DSP + LK GD I+EV+ ++Q +H++ V+ + G+ V +VQ
Sbjct: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNA--GNPVVFIVQSLS- 1160
Query: 725 PVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ--TD 782
P+ P K + N +Q + +P PP + P + TD
Sbjct: 1161 STPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAP----------PPMKLPPPYKALTD 1210
Query: 783 SSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDI 842
S + + + + R Y + P GE I I
Sbjct: 1211 DSDENEEEDAFTDQKIRQRYADLP-----------------------GELHI-------I 1240
Query: 843 FLWRKETGFGFRILGGNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSH 901
L + + G G + G + I++ I P G A DGR+R GDEL+ ++ + G+SH
Sbjct: 1241 ELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSH 1300
Query: 902 QLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSH---HSSNQPASLTEE--- 955
Q +++ A + + V + T VPS + S S +P S E+
Sbjct: 1301 QNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSV 1360
Query: 956 ----KRTPQG----------------------SQNSLNTVSSGSGSTSGIGSGGGGGSGV 989
K+ P+ SQ +S ST +G GG
Sbjct: 1361 EVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAP 1420
Query: 990 VST------VV--QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRII 1041
+S +V Q +EI +G + G G IV P NA V I +
Sbjct: 1421 LSVDPATCPIVPGQEMIIEISKGRS-GLGLSIVGGKDTPL------NAIV-----IHEVY 1468
Query: 1042 EGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLL 1101
E A R G+L GD+IL VNG + N SH + + +++ V L +
Sbjct: 1469 EEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVY----------- 1517
Query: 1102 TNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA-KG 1160
R+ + E E + V+L++ A +G
Sbjct: 1518 -----------------------RDEAHYRDEENLEI-----------FPVDLQKKAGRG 1543
Query: 1161 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
G S+ G R +++ + + G A+ G++ GD+IL +NGE +N ++K
Sbjct: 1544 LGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKC 1602
Query: 1221 GGRRVRLFLKR 1231
V+L + R
Sbjct: 1603 AQGLVQLEIGR 1613
Score = 85.9 bits (211), Expect = 2e-16
Identities = 77/246 (31%), Positives = 111/246 (45%), Gaps = 34/246 (13%)
Query: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
G G I+G G ++I IV GAAD DGRL GD+++ V+G + S + V +++
Sbjct: 1543 GLGLSIVGKRN-GSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
Query: 910 QAAKQGHVNLTVRRKVV---FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSL 966
A QG V L + R + T S HSS P+ G QN +
Sbjct: 1602 CA--QGLVQLEIGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAP----VITGLQNLV 1655
Query: 967 NT--VSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGT 1024
T VS S SG T ++P VEI R ++ G I G+
Sbjct: 1656 GTKRVSDPSQKNSG-------------TDMEPRTVEINRELSDALGISIAGG-----RGS 1697
Query: 1025 TFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084
G+ +P I I A R KLKVGDRI+++NG + SH+D+VNL+K A
Sbjct: 1698 PLGD----IPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGR 1753
Query: 1085 VTLRII 1090
+ L+++
Sbjct: 1754 IILQVV 1759
Score = 85.1 bits (209), Expect = 4e-16
Identities = 173/851 (20%), Positives = 314/851 (36%), Gaps = 132/851 (15%)
Query: 408 QQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPE-PAREVPLQGKPFFTRNPSEL 466
Q+++Q+ Q Q SA + + E P RE +G+ T N S
Sbjct: 1007 QRREQEDLPLYQHQATRVISKASAYTGMLSSRYATDTCELPERE---EGEGEETPNFSHW 1063
Query: 467 KGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQ---------IKSLVLDGPAALDGKMETGD 517
I R+ + G ++VGG + L+ IK ++ D PA ++TGD
Sbjct: 1064 GPPRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGD 1123
Query: 518 VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILD 577
I+ V+ + +H++ V+ ++ G P+ F +++ + +
Sbjct: 1124 KILEVSGVDLQNASHSEAVEAIKNA------------GNPVVFIVQSLSSTPRVIPNVHN 1171
Query: 578 KEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVS---LASS 634
K I G + D+ + G P A + +S D + +
Sbjct: 1172 KANKIT-GNQNQDTQEKKEKRQGTAPPPMKLPPPYKA-LTDDSDENEEEDAFTDQKIRQR 1229
Query: 635 IATQP-ELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG-----LKEGDLIVE 688
A P EL + + K G G ++A + + + +P ++ GD ++E
Sbjct: 1230 YADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLE 1289
Query: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPV------PKKSPKSQPLERKDSQ 742
+N + + +H ++ P S+V L+ R V P P S P +D
Sbjct: 1290 INNQILYGRSHQNASAIIKTAP--SKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQS 1347
Query: 743 NSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMY 802
+ S S+ + + P +E+ + QK P +Q +
Sbjct: 1348 GTEPISSEEDGSVEVG--------IKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLA 1399
Query: 803 ENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNE-P 861
+ A G + + S + CPI QE I + + +G G I+GG + P
Sbjct: 1400 PASSYHSTDADFTGYGGFQAPL-SVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTP 1458
Query: 862 GEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 921
I I + GAA DGRL +GD+++ V+G + SH+ + ++Q ++ V L V
Sbjct: 1459 LNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITALRQTPQK--VRLVV 1516
Query: 922 RRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSG-STSGIG 980
R + E+ P L +K+ +G S+ +GSG S I
Sbjct: 1517 YRDEAHYRDEENLEI-----------FPVDL--QKKAGRGLGLSIVGKRNGSGVFISDIV 1563
Query: 981 SGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRI 1040
GG + + ++Q + GE+ + + S+ T A + +IGR+
Sbjct: 1564 K--GGAADLDGRLIQGDQILSVNGED-------MRNASQETVATILKCAQGLVQLEIGRL 1614
Query: 1041 IEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATL 1100
GS R + N +HS S A +
Sbjct: 1615 RAGS--------WTSARTTSQNSQGSQQSAHSSC-------------------HPSFAPV 1647
Query: 1101 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERG-AK 1159
+T + + T+ + P Q++ P+ TVE+ R +
Sbjct: 1648 ITGLQNLV--------------GTKRVSDPSQKNSGTDMEPR--------TVEINRELSD 1685
Query: 1160 GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1216
G S+ GGR ++ +++ + G A R K+++GD I+ ING+ + H+ +
Sbjct: 1686 ALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQPLDGLSHADVVN 1745
Query: 1217 LIKNGGRRVRL 1227
L+KN R+ L
Sbjct: 1746 LLKNAYGRIIL 1756
Score = 73.2 bits (178), Expect = 2e-12
Identities = 89/430 (20%), Positives = 162/430 (37%), Gaps = 93/430 (21%)
Query: 850 GFGFRILG---GNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGK-SHQLVV 905
G GF ++ N I++ + P AD D RL+ D+++ ++ TP+ SHQ +
Sbjct: 144 GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI 203
Query: 906 QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS 965
L+QQ G + L V R+ V T +SS + + P ++ G
Sbjct: 204 ALLQQTT--GSLRLIVAREPVHTKSST-------SSSLNDTTLPETVC------WGHVEE 248
Query: 966 LNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTT 1025
+ ++ GSG G G GG SGVV
Sbjct: 249 VELINDGSGL--GFGIVGGKTSGVV----------------------------------- 271
Query: 1026 FGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1085
+ I+ G ADR G+L+ GD IL + G ++ + + +++ GN+V
Sbjct: 272 -----------VRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSV 320
Query: 1086 TLRIIPGDESSNATLLTNAEK-----IATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
+ ++ D + + ++ A + T+ + S ET N +++ Q
Sbjct: 321 RM-LVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQ----- 374
Query: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
G + G+ +YV + A G +++ D+I+
Sbjct: 375 --------------SLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVA 420
Query: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRNEKLGEACF 1260
++G + + +E+++N G+ V L L R S + PP+ + E L
Sbjct: 421 VDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV-VEPLKPPAL 479
Query: 1261 YLMGHNQTTT 1270
+L G +T T
Sbjct: 480 FLTGAVETET 489
Score = 69.7 bits (169), Expect = 2e-11
Identities = 100/495 (20%), Positives = 189/495 (38%), Gaps = 103/495 (20%)
Query: 817 KGEREREINSTNFGECPIPD-YQEQDIFLWRKETGFGFRILGGN---------EPGEPIY 866
+GE E N +++G I + ++E ++ L G I+GG E + I+
Sbjct: 1051 EGEGEETPNFSHWGPPRIVEIFREPNVSL-------GISIVGGQTVIKRLKNGEELKGIF 1103
Query: 867 IGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVV 926
I ++ A L++GD+++ V G + SH V+ ++ A +
Sbjct: 1104 IKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTP 1163
Query: 927 FAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNS-LNTVSSGSGSTSGIGSGGGG 985
+P N+ ++ + NQ E+K QG+ + T
Sbjct: 1164 RVIPNVHNK-----ANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEE 1218
Query: 986 GSGVVSTVVQPYD--------VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKI 1037
+ + Q Y +E+ + +N G G + + R +
Sbjct: 1219 DAFTDQKIRQRYADLPGELHIIELEKDKN-GLGLSLAGNKDRSRMSIFV----------V 1267
Query: 1038 GRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSN 1097
G EG PA G++++GD +L +N + +SH + +IK A + V L I +++ N
Sbjct: 1268 GINPEG-PAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIRNEDAVN 1326
Query: 1098 ATLLT---------NAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ- 1147
+T ++ + + T + + G+ E P+ ES F+ Q Q++
Sbjct: 1327 QMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESES-FKLAVSQMKQQKY 1385
Query: 1148 ------------------------DF------------------------YTVELERGAK 1159
DF +E+ +G
Sbjct: 1386 PTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRS 1445
Query: 1160 GFGFSLRGGREYNMDLYVLR-LAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
G G S+ GG++ ++ V+ + E+G A R G++ GD+ILE+NG +N H AI +
Sbjct: 1446 GLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNSSHEEAITAL 1505
Query: 1219 KNGGRRVRLFLKRGD 1233
+ ++VRL + R +
Sbjct: 1506 RQTPQKVRLVVYRDE 1520
Score = 63.5 bits (153), Expect = 1e-09
Identities = 70/259 (27%), Positives = 110/259 (42%), Gaps = 51/259 (19%)
Query: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058
++I R G GF +V+ S+ G + + + GS ADR +LK D+I
Sbjct: 135 IDIERPSTGGLGFSVVALRSQ-----NLGKVDIFVKD----VQPGSVADRDQRLKENDQI 185
Query: 1059 LAVNGCSI-TNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
LA+N + N SH + L+++ T +LR+I E HT S
Sbjct: 186 LAINHTPLDQNISHQQAIALLQQ--TTGSLRLIVARE-----------------PVHTKS 226
Query: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYV 1177
T + N T P+ VEL G GF + GG+ + V
Sbjct: 227 --STSSSLNDT----------TLPETVCWGHVEEVELINDGSGLGFGIVGGK--TSGVVV 272
Query: 1178 LRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR---GDG 1234
+ G A+R G+++ GD IL+I G + M + ++++N G VR+ + R GD
Sbjct: 273 RTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDI 332
Query: 1235 SV--PEYAMIP---PNIAA 1248
SV P A +P P +A+
Sbjct: 333 SVTPPAPAALPVALPTVAS 351
Score = 51.2 bits (121), Expect = 6e-06
Identities = 35/109 (32%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 474 KLRKSSRGFGFTVVGGDEPDE----FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
+L K +G GF+++ +P + + I+SLV DG A G + GD +VSVN+ C+
Sbjct: 688 ELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLDN 747
Query: 530 HTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDK 578
+ A+ V+I +++P G V L +C+ PL D ++ + ++ S + DK
Sbjct: 748 TSLAEAVEILKAVPPGL-VHLGICK--PLVEDNEEESCYILHSSSNEDK 793
Score = 43.5 bits (101), Expect = 0.001
Identities = 43/156 (27%), Positives = 69/156 (44%), Gaps = 11/156 (7%)
Query: 1087 LRIIPGDESSNAT-----LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ-FEFKA 1140
L IP D S+N LL + T H PS T PK ++ F
Sbjct: 64 LNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNSTVSGLFPWTPKLGNEDFNSVI 123
Query: 1141 PQATQEQDFYTVELERGAKG-FGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGD 1196
Q Q + +++ER + G GFS+ R N+ D++V + A+R +++ D
Sbjct: 124 QQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKEND 183
Query: 1197 EILEIN-GETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+IL IN +N+ H +AI L++ +RL + R
Sbjct: 184 QILAINHTPLDQNISHQQAIALLQQTTGSLRLIVAR 219
Score = 41.6 bits (96), Expect = 0.005
Identities = 27/87 (31%), Positives = 45/87 (51%), Gaps = 4/87 (4%)
Query: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
G +L G GF +VGG + ++++V G A DG+++TGD I+ + T V
Sbjct: 244 GHVEEVELINDGSGLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNV 301
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCR 554
G T QV ++ ++ G SV + + R
Sbjct: 302 QGMTSEQVAQVLRN--CGNSVRMLVAR 326
Score = 37.4 bits (85), Expect = 0.093
Identities = 33/101 (32%), Positives = 49/101 (48%), Gaps = 13/101 (12%)
Query: 644 VHIVKGPMGFGFTIADSPGG--GGQRVKQIVD---SPRCRGLKEGDLIVEVNKKNVQALT 698
V ++ G GF I GG G V+ IV + R L+ GD I+++ NVQ +T
Sbjct: 249 VELINDGSGLGFGIV---GGKTSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMT 305
Query: 699 HNQVVDMLVECPKGSEVTLLVQR---GGLPVPKKSPKSQPL 736
QV +L C G+ V +LV R G + V +P + P+
Sbjct: 306 SEQVAQVLRNC--GNSVRMLVARDPAGDISVTPPAPAALPV 344
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 93.6 bits (231), Expect = 1e-18
Identities = 114/536 (21%), Positives = 218/536 (40%), Gaps = 67/536 (12%)
Query: 731 PKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD 790
P Q + + S Q S S SL + ++++ + + + ++DSS + D
Sbjct: 991 PPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIE--D 1048
Query: 791 PFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFL--WRKE 848
P + + +M+ +SG S + + N I E++I L +K+
Sbjct: 1049 PGQAYVLGMTMH---------SSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKD 1099
Query: 849 T--GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 903
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH
Sbjct: 1100 AKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHA 1159
Query: 904 VVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSH---HSSNQPASLTEEKRTPQ 960
++++Q A + + ++ ++ + VP T + + ++ S Q +++ +
Sbjct: 1160 AIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHH 1219
Query: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
S+ +L +S S G GG G +S+ + R E+ +S+S+
Sbjct: 1220 WSRGTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQS 1259
Query: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
+ F + + + GSP+ + S T K V +
Sbjct: 1260 QVNGFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSD 1317
Query: 1081 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
G++ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1318 RGDS---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFS 1357
Query: 1141 PQATQEQDFYTVELERGAKGFGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGDE 1197
+ D + VEL + G S+ GG ++ +YV + G AE G++ GD
Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1417
Query: 1198 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDG-SVPEYAMIPPNIAACMRN 1252
+L +NG + + H +A+E ++N G+ V L L++G + E+ + P +N
Sbjct: 1418 VLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1473
Score = 88.6 bits (218), Expect = 4e-17
Identities = 149/692 (21%), Positives = 250/692 (36%), Gaps = 149/692 (21%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P+D VT V KE I
Sbjct: 1156 SHHAAIEILQNA-------------------PED-----VTLVISQPKEKI-----SKVP 1186
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
S H + K K + A +S+ H + T+ HI +
Sbjct: 1187 STPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLR--------------HISENS 1232
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1233 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1267
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
+ T + G P P K+ E N S+ T P S
Sbjct: 1268 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSK----------TKKPGIS------- 1310
Query: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFG 830
D TD S + D + S ++ S + S ++N F
Sbjct: 1311 --------DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSN-----KMNFKTFS 1357
Query: 831 ECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEP---IYIGHIVPLGAADTDGRLRSGDE 887
P ++ L + + G + GG IY+ ++P GAA++DGR+ GD
Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1417
Query: 888 LICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN 947
++ V+G + G +H+ V+ ++ + H+ L + SP S H
Sbjct: 1418 VLAVNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSPTSKEHVPV 1463
Query: 948 QP-ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006
P +L+++ QG + T S V + E++ +N
Sbjct: 1464 TPQCTLSDQNAQGQGPEKVKKTTQVKD----------------YSFVTEENTFEVKLFKN 1507
Query: 1007 -EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCS 1065
G GF S SR + A ++ ++ G PA GK+ VGD IL VNG S
Sbjct: 1508 SSGLGF----SFSRED--NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561
Query: 1066 ITNKSHSDIVNLIKEAGNTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQ 1119
+ S ++++ ++ V L R PG + LLT + A + ++ SQ
Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1621
Query: 1120 GTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1151
E ++ + S K ++ +D Y+
Sbjct: 1622 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYS 1653
Score = 70.5 bits (171), Expect = 1e-11
Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
+I A+ G++ GDR+LAVNG S+ +H V ++ G V L + ++ + T
Sbjct: 1400 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL---EKGQSPT 1456
Query: 1100 LLTNAEKIATITTTHTPSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1158
+ T + +Q QG ++ + TT+ K S E++ + V+L + +
Sbjct: 1457 SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--------FVTEENTFEVKLFKNS 1508
Query: 1159 KGFGFSLRGGREYNMD--------LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1210
G GFS RE N+ + V +L PA GK+ +GD IL++NG + K +
Sbjct: 1509 SGLGFSF--SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1566
Query: 1211 HSRAIELIKNGGRRVRLFLKR-GDGSVPE 1238
I ++ V L L R G +PE
Sbjct: 1567 QQEVISALRGTAPEVFLLLCRPPPGVLPE 1595
Score = 57.8 bits (138), Expect = 7e-08
Identities = 107/455 (23%), Positives = 174/455 (38%), Gaps = 113/455 (24%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1503 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1562
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1563 KGLSQQEVISALRG--TAPEVFLLLCR--PPPGVLPEIDTALLT--PLQSPAQVLPNSSK 1616
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1617 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1676
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1677 SALH--------------------QTLSNMVS---------------------QAQSHH- 1694
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1695 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1723
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR-SMYEN-RPMSPSPASGLSKGE 819
+ + + P+ P ++ P Q++S+ D + I S + EN P+ + L E
Sbjct: 1724 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1782
Query: 820 REREINSTNFGECPIPDYQEQDIFLWRKETG-FGFRILGGNEPGEPIYIGHIVPLGAADT 878
E E+ T L + E G GF + GN+ Y+ H V A +
Sbjct: 1783 LEVELLIT----------------LIKSEKGSLGFTVTKGNQ-RIGCYV-HDVIQDPAKS 1824
Query: 879 DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
DGRL+ GD LI V+ T V +H V L++ A+K
Sbjct: 1825 DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK 1859
Score = 47.4 bits (111), Expect = 9e-05
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1045 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1821 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1865
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 81/338 (23%)
Query: 459 FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEF---LQIKSLVLDGPAALDGKMET 515
F+ +P + G +L K+ G +V GG + +K+++ G A DG++
Sbjct: 1356 FSSSPPK-PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1414
Query: 516 GDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAI 575
GD +++VN + G TH Q V+ ++ G V L L +G P VT
Sbjct: 1415 GDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQ----SPTSKEHVPVTPQCT 1468
Query: 576 LDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
L + G E K K +KD S
Sbjct: 1469 LSDQNAQGQGPE----------KVKKTTQVKD-------------------------YSF 1493
Query: 636 ATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRVKQIV---DSPRCRGLKEGDL 685
T+ V + K G GF+ I + RVK++ + + GD+
Sbjct: 1494 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1553
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR---GGLP-------VPKKSP-- 731
I++VN +++ L+ +V+ L +G+ EV LL+ R G LP P +SP
Sbjct: 1554 ILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQ 1609
Query: 732 --------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
SQP + S +S ++ +S SPS
Sbjct: 1610 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1647
Score = 47.0 bits (110), Expect = 1e-04
Identities = 31/108 (28%), Positives = 59/108 (54%), Gaps = 8/108 (7%)
Query: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1792 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1847
Query: 1212 SRAIELIKNGGRRVRLFLKRGDGSVPEYAMIP---PNIAACMRNEKLG 1256
+ A+ L++ + VRL + R +P M+P P+I E+LG
Sbjct: 1848 TDAVNLLRAASKTVRLVIGR-VLELPRIPMLPHLLPDITLTCNKEELG 1894
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1709 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1759
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1760 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1809
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1810 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1865
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1866 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1917
Query: 613 PADVASN 619
A + N
Sbjct: 1918 VAAIEGN 1924
>gi|153070258 MAGI family member, X-linked isoform a [Homo sapiens]
Length = 334
Score = 92.8 bits (229), Expect = 2e-18
Identities = 62/165 (37%), Positives = 97/165 (58%), Gaps = 10/165 (6%)
Query: 1073 DIVNLIKEAGNTVTLR---IIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTK 1129
D+ L++ AG T+ LR + +S++ + + ATI H P Q ET N
Sbjct: 47 DVAALVRRAGATLRLRRKEAVSVLDSADIEVTDSRLPHATIVD-HRP-QHRWLETCNA-- 102
Query: 1130 PKQESQFEFK-APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPA 1186
P Q Q + + AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA
Sbjct: 103 PPQLIQGKARSAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPA 162
Query: 1187 ERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+RCG++ +GD +L INGE+T+ + H++A+E I+ GG ++ L ++R
Sbjct: 163 QRCGRLEVGDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 207
Score = 56.2 bits (134), Expect = 2e-07
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 7/115 (6%)
Query: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALD 510
+QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA
Sbjct: 107 IQGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRC 165
Query: 511 GKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
G++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 166 GRLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 216
Score = 47.0 bits (110), Expect = 1e-04
Identities = 44/163 (26%), Positives = 69/163 (42%), Gaps = 36/163 (22%)
Query: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1056
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VGD
Sbjct: 124 FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 172
Query: 1057 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------IPG-----------------D 1093
+L +NG S +H+ V I+ G + L I PG D
Sbjct: 173 LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPD 232
Query: 1094 ESSN--ATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1134
S + +T + +T H PS+ ++TR + +P E+
Sbjct: 233 RSPDPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 275
Score = 45.1 bits (105), Expect = 4e-04
Identities = 52/189 (27%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 125 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 184
Query: 697 LTHNQVVDMLVECPKGSEVTLLVQR-----------------GGLPV-PKKSPKSQPLER 738
LTH Q V+ + G ++ L+++R G +P P +SP E
Sbjct: 185 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSPDPGGPEV 242
Query: 739 KDSQNSSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPD 790
S++SS V S T SP S + + P P E +A D D P
Sbjct: 243 TGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPG 301
Query: 791 PFKIWAQSR 799
P+ + ++ R
Sbjct: 302 PWLVPSEER 310
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 91.7 bits (226), Expect = 4e-18
Identities = 90/413 (21%), Positives = 171/413 (41%), Gaps = 52/413 (12%)
Query: 850 GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQ 906
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH ++
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 907 LMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN---QPASLTEEKRTPQGSQ 963
++Q A + + ++ ++ + VP T + + ++ + Q +++ + S+
Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1031
Query: 964 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAG 1023
+L +S S G GG G +S+ + R E+ +S+S+ +
Sbjct: 1032 GTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQSQVN 1071
Query: 1024 TTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1083
F + + + GSP+ + S T K V + G+
Sbjct: 1072 GFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1129
Query: 1084 TVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQA 1143
+ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1130 S---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFSSSP 1169
Query: 1144 TQEQDFYTVELERGAKGFGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGDEILE 1200
+ D + VEL + G S+ GG ++ +YV + G AE G++ GD +L
Sbjct: 1170 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1229
Query: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDG-SVPEYAMIPPNIAACMRN 1252
+NG + + H +A+E ++N G+ V L L++G + E+ + P +N
Sbjct: 1230 VNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1282
Score = 88.6 bits (218), Expect = 4e-17
Identities = 149/692 (21%), Positives = 250/692 (36%), Gaps = 149/692 (21%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 905 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 964
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P+D VT V KE I
Sbjct: 965 SHHAAIEILQNA-------------------PED-----VTLVISQPKEKI-----SKVP 995
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
S H + K K + A +S+ H + T+ HI +
Sbjct: 996 STPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLR--------------HISENS 1041
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1042 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1076
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
+ T + G P P K+ E N S+ T P S
Sbjct: 1077 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSK----------TKKPGIS------- 1119
Query: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFG 830
D TD S + D + S ++ S + S ++N F
Sbjct: 1120 --------DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSN-----KMNFKTFS 1166
Query: 831 ECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEP---IYIGHIVPLGAADTDGRLRSGDE 887
P ++ L + + G + GG IY+ ++P GAA++DGR+ GD
Sbjct: 1167 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1226
Query: 888 LICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN 947
++ V+G + G +H+ V+ ++ + H+ L + SP S H
Sbjct: 1227 VLAVNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSPTSKEHVPV 1272
Query: 948 QP-ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006
P +L+++ QG + T S V + E++ +N
Sbjct: 1273 TPQCTLSDQNAQGQGPEKVKKTTQVKD----------------YSFVTEENTFEVKLFKN 1316
Query: 1007 -EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCS 1065
G GF S SR + A ++ ++ G PA GK+ VGD IL VNG S
Sbjct: 1317 SSGLGF----SFSRED--NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370
Query: 1066 ITNKSHSDIVNLIKEAGNTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQ 1119
+ S ++++ ++ V L R PG + LLT + A + ++ SQ
Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1430
Query: 1120 GTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1151
E ++ + S K ++ +D Y+
Sbjct: 1431 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYS 1462
Score = 70.5 bits (171), Expect = 1e-11
Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
+I A+ G++ GDR+LAVNG S+ +H V ++ G V L + ++ + T
Sbjct: 1209 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL---EKGQSPT 1265
Query: 1100 LLTNAEKIATITTTHTPSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1158
+ T + +Q QG ++ + TT+ K S E++ + V+L + +
Sbjct: 1266 SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--------FVTEENTFEVKLFKNS 1317
Query: 1159 KGFGFSLRGGREYNMD--------LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1210
G GFS RE N+ + V +L PA GK+ +GD IL++NG + K +
Sbjct: 1318 SGLGFSF--SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1375
Query: 1211 HSRAIELIKNGGRRVRLFLKR-GDGSVPE 1238
I ++ V L L R G +PE
Sbjct: 1376 QQEVISALRGTAPEVFLLLCRPPPGVLPE 1404
Score = 57.8 bits (138), Expect = 7e-08
Identities = 107/455 (23%), Positives = 174/455 (38%), Gaps = 113/455 (24%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1312 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1371
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1372 KGLSQQEVISALRG--TAPEVFLLLCR--PPPGVLPEIDTALLT--PLQSPAQVLPNSSK 1425
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1426 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1485
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1486 SALH--------------------QTLSNMVS---------------------QAQSHH- 1503
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1504 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1532
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR-SMYEN-RPMSPSPASGLSKGE 819
+ + + P+ P ++ P Q++S+ D + I S + EN P+ + L E
Sbjct: 1533 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1591
Query: 820 REREINSTNFGECPIPDYQEQDIFLWRKETG-FGFRILGGNEPGEPIYIGHIVPLGAADT 878
E E+ T L + E G GF + GN+ Y+ H V A +
Sbjct: 1592 LEVELLIT----------------LIKSEKGSLGFTVTKGNQ-RIGCYV-HDVIQDPAKS 1633
Query: 879 DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
DGRL+ GD LI V+ T V +H V L++ A+K
Sbjct: 1634 DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK 1668
Score = 52.8 bits (125), Expect = 2e-06
Identities = 28/114 (24%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 1143 ATQEQDFYTVELERGAK-GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEI 1198
++ E++ V L++ AK G GF + GG + ++ +++ +A GPA+ G ++ GD +
Sbjct: 894 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 953
Query: 1199 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRN 1252
+ +N + + + H AIE+++N V L + + + + P ++ M+N
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKN 1007
Score = 47.4 bits (111), Expect = 9e-05
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1045 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1630 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1674
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 81/338 (23%)
Query: 459 FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEF---LQIKSLVLDGPAALDGKMET 515
F+ +P + G +L K+ G +V GG + +K+++ G A DG++
Sbjct: 1165 FSSSPPK-PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1223
Query: 516 GDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAI 575
GD +++VN + G TH Q V+ ++ G V L L +G P VT
Sbjct: 1224 GDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQ----SPTSKEHVPVTPQCT 1277
Query: 576 LDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
L + G E K K +KD S
Sbjct: 1278 LSDQNAQGQGPE----------KVKKTTQVKD-------------------------YSF 1302
Query: 636 ATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRVKQIV---DSPRCRGLKEGDL 685
T+ V + K G GF+ I + RVK++ + + GD+
Sbjct: 1303 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1362
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR---GGLP-------VPKKSP-- 731
I++VN +++ L+ +V+ L +G+ EV LL+ R G LP P +SP
Sbjct: 1363 ILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQ 1418
Query: 732 --------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
SQP + S +S ++ +S SPS
Sbjct: 1419 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1456
Score = 47.0 bits (110), Expect = 1e-04
Identities = 31/108 (28%), Positives = 59/108 (54%), Gaps = 8/108 (7%)
Query: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1601 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1656
Query: 1212 SRAIELIKNGGRRVRLFLKRGDGSVPEYAMIP---PNIAACMRNEKLG 1256
+ A+ L++ + VRL + R +P M+P P+I E+LG
Sbjct: 1657 TDAVNLLRAASKTVRLVIGR-VLELPRIPMLPHLLPDITLTCNKEELG 1703
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1518 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1568
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1569 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1618
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1619 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1674
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1675 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1726
Query: 613 PADVASN 619
A + N
Sbjct: 1727 VAAIEGN 1733
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058
V +++ G GF I+ G G + + I + G PAD G LK GDR+
Sbjct: 903 VNLKKDAKYGLGFQIIG-------GEKMGRLDLGI--FISSVAPGGPADLDGCLKPGDRL 953
Query: 1059 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
++VN S+ SH + +++ A VTL I
Sbjct: 954 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 984
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 91.7 bits (226), Expect = 4e-18
Identities = 90/413 (21%), Positives = 171/413 (41%), Gaps = 52/413 (12%)
Query: 850 GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQ 906
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH ++
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 907 LMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN---QPASLTEEKRTPQGSQ 963
++Q A + + ++ ++ + VP T + + ++ + Q +++ + S+
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSR 1203
Query: 964 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAG 1023
+L +S S G GG G +S+ + R E+ +S+S+ +
Sbjct: 1204 GTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQSQVN 1243
Query: 1024 TTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGN 1083
F + + + GSP+ + S T K V + G+
Sbjct: 1244 GFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGD 1301
Query: 1084 TVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQA 1143
+ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1302 S---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFSSSP 1341
Query: 1144 TQEQDFYTVELERGAKGFGFSLRGGREYNM---DLYVLRLAEDGPAERCGKMRIGDEILE 1200
+ D + VEL + G S+ GG ++ +YV + G AE G++ GD +L
Sbjct: 1342 PKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLA 1401
Query: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKRGDG-SVPEYAMIPPNIAACMRN 1252
+NG + + H +A+E ++N G+ V L L++G + E+ + P +N
Sbjct: 1402 VNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN 1454
Score = 88.6 bits (218), Expect = 4e-17
Identities = 149/692 (21%), Positives = 250/692 (36%), Gaps = 149/692 (21%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 1077 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1136
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P+D VT V KE I
Sbjct: 1137 SHHAAIEILQNA-------------------PED-----VTLVISQPKEKI-----SKVP 1167
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
S H + K K + A +S+ H + T+ HI +
Sbjct: 1168 STPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLR--------------HISENS 1213
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1214 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1248
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
+ T + G P P K+ E N S+ T P S
Sbjct: 1249 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSK----------TKKPGIS------- 1291
Query: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFG 830
D TD S + D + S ++ S + S ++N F
Sbjct: 1292 --------DVTDYSDRGDSDMDEATYSSSQDHQTPKQESSSSVNTSN-----KMNFKTFS 1338
Query: 831 ECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEP---IYIGHIVPLGAADTDGRLRSGDE 887
P ++ L + + G + GG IY+ ++P GAA++DGR+ GD
Sbjct: 1339 SSPPKPGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDR 1398
Query: 888 LICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSN 947
++ V+G + G +H+ V+ ++ + H+ L + SP S H
Sbjct: 1399 VLAVNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSPTSKEHVPV 1444
Query: 948 QP-ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006
P +L+++ QG + T S V + E++ +N
Sbjct: 1445 TPQCTLSDQNAQGQGPEKVKKTTQVKD----------------YSFVTEENTFEVKLFKN 1488
Query: 1007 -EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCS 1065
G GF S SR + A ++ ++ G PA GK+ VGD IL VNG S
Sbjct: 1489 SSGLGF----SFSRED--NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542
Query: 1066 ITNKSHSDIVNLIKEAGNTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQ 1119
+ S ++++ ++ V L R PG + LLT + A + ++ SQ
Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQP 1602
Query: 1120 GTQETRNTTKPKQESQFEFKAPQATQEQDFYT 1151
E ++ + S K ++ +D Y+
Sbjct: 1603 SCVEQSTSSDENEMSDKSKKQCKSPSRRDSYS 1634
Score = 70.5 bits (171), Expect = 1e-11
Identities = 57/209 (27%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
+I A+ G++ GDR+LAVNG S+ +H V ++ G V L + ++ + T
Sbjct: 1381 VIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLL---EKGQSPT 1437
Query: 1100 LLTNAEKIATITTTHTPSQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1158
+ T + +Q QG ++ + TT+ K S E++ + V+L + +
Sbjct: 1438 SKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYS--------FVTEENTFEVKLFKNS 1489
Query: 1159 KGFGFSLRGGREYNMD--------LYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1210
G GFS RE N+ + V +L PA GK+ +GD IL++NG + K +
Sbjct: 1490 SGLGFSF--SREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLS 1547
Query: 1211 HSRAIELIKNGGRRVRLFLKR-GDGSVPE 1238
I ++ V L L R G +PE
Sbjct: 1548 QQEVISALRGTAPEVFLLLCRPPPGVLPE 1576
Score = 57.8 bits (138), Expect = 7e-08
Identities = 107/455 (23%), Positives = 174/455 (38%), Gaps = 113/455 (24%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1484 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1543
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1544 KGLSQQEVISALRG--TAPEVFLLLCR--PPPGVLPEIDTALLT--PLQSPAQVLPNSSK 1597
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1598 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1657
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1658 SALH--------------------QTLSNMVS---------------------QAQSHH- 1675
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1676 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1704
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR-SMYEN-RPMSPSPASGLSKGE 819
+ + + P+ P ++ P Q++S+ D + I S + EN P+ + L E
Sbjct: 1705 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1763
Query: 820 REREINSTNFGECPIPDYQEQDIFLWRKETG-FGFRILGGNEPGEPIYIGHIVPLGAADT 878
E E+ T L + E G GF + GN+ Y+ H V A +
Sbjct: 1764 LEVELLIT----------------LIKSEKGSLGFTVTKGNQ-RIGCYV-HDVIQDPAKS 1805
Query: 879 DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
DGRL+ GD LI V+ T V +H V L++ A+K
Sbjct: 1806 DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK 1840
Score = 52.8 bits (125), Expect = 2e-06
Identities = 28/114 (24%), Positives = 61/114 (53%), Gaps = 4/114 (3%)
Query: 1143 ATQEQDFYTVELERGAK-GFGFSLRGGREY---NMDLYVLRLAEDGPAERCGKMRIGDEI 1198
++ E++ V L++ AK G GF + GG + ++ +++ +A GPA+ G ++ GD +
Sbjct: 1066 SSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRL 1125
Query: 1199 LEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYAMIPPNIAACMRN 1252
+ +N + + + H AIE+++N V L + + + + P ++ M+N
Sbjct: 1126 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKN 1179
Score = 47.4 bits (111), Expect = 9e-05
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1045 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1802 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1846
Score = 47.0 bits (110), Expect = 1e-04
Identities = 78/338 (23%), Positives = 127/338 (37%), Gaps = 81/338 (23%)
Query: 459 FTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEF---LQIKSLVLDGPAALDGKMET 515
F+ +P + G +L K+ G +V GG + +K+++ G A DG++
Sbjct: 1337 FSSSPPK-PGDIFEVELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHK 1395
Query: 516 GDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAI 575
GD +++VN + G TH Q V+ ++ G V L L +G P VT
Sbjct: 1396 GDRVLAVNGVSLEGATHKQAVETLRN--TGQVVHLLLEKGQ----SPTSKEHVPVTPQCT 1449
Query: 576 LDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
L + G E K K +KD S
Sbjct: 1450 LSDQNAQGQGPE----------KVKKTTQVKD-------------------------YSF 1474
Query: 636 ATQPELITVHIVKGPMGFGFT-------IADSPGGGGQRVKQIV---DSPRCRGLKEGDL 685
T+ V + K G GF+ I + RVK++ + + GD+
Sbjct: 1475 VTEENTFEVKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDV 1534
Query: 686 IVEVNKKNVQALTHNQVVDMLVECPKGS--EVTLLVQR---GGLP-------VPKKSP-- 731
I++VN +++ L+ +V+ L +G+ EV LL+ R G LP P +SP
Sbjct: 1535 ILKVNGASLKGLSQQEVISAL----RGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQ 1590
Query: 732 --------KSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
SQP + S +S ++ +S SPS
Sbjct: 1591 VLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPS 1628
Score = 47.0 bits (110), Expect = 1e-04
Identities = 31/108 (28%), Positives = 59/108 (54%), Gaps = 8/108 (7%)
Query: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1773 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1828
Query: 1212 SRAIELIKNGGRRVRLFLKRGDGSVPEYAMIP---PNIAACMRNEKLG 1256
+ A+ L++ + VRL + R +P M+P P+I E+LG
Sbjct: 1829 TDAVNLLRAASKTVRLVIGR-VLELPRIPMLPHLLPDITLTCNKEELG 1875
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1690 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1740
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1741 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1790
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1791 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1846
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1847 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1898
Query: 613 PADVASN 619
A + N
Sbjct: 1899 VAAIEGN 1905
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 9/91 (9%)
Query: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058
V +++ G GF I+ G G + + I + G PAD G LK GDR+
Sbjct: 1075 VNLKKDAKYGLGFQIIG-------GEKMGRLDLGI--FISSVAPGGPADLDGCLKPGDRL 1125
Query: 1059 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
++VN S+ SH + +++ A VTL I
Sbjct: 1126 ISVNSVSLEGVSHHAAIEILQNAPEDVTLVI 1156
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 90.1 bits (222), Expect = 1e-17
Identities = 111/446 (24%), Positives = 180/446 (40%), Gaps = 105/446 (23%)
Query: 806 PMSPSPASGLSKGEREREINSTNFGECP------IPDYQEQDIFLWRKETGFGFRILGGN 859
P+ SPA ++ I +T+ E P + + ++I L R +G GF I GG
Sbjct: 21 PLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGT 80
Query: 860 E-----PGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQ 914
+ I+I I+P GAA DGRLR D ++ V+ V +H V+ +++A
Sbjct: 81 DNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAG-- 138
Query: 915 GHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSG 974
V L V R+ PA E + +G +
Sbjct: 139 SIVRLYVMRR----------------------KPPAEKVMEIKLIKGPK----------- 165
Query: 975 STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMP 1034
G+G GG G + G+N + I+ E G
Sbjct: 166 ---GLGFSIAGGVG----------NQHIPGDNSIYVTKII------EGGAA--------- 197
Query: 1035 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDE 1094
HK GR+ ++GD+ILAVN + + H D V +K + V L++ +
Sbjct: 198 HKDGRL------------QIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA---K 242
Query: 1095 SSNATLLTNAEKIATITTTHT---------PSQQGTQETRNTTKPKQESQFEFKAPQATQ 1145
SNA L+++ ITT+++ S GT T P ++ A
Sbjct: 243 PSNA-YLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMT-PTSPRRYSPVAKDLLG 300
Query: 1146 EQDF----YTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEI 1201
E+D + + RG+ G GF++ GG E +++ + GPA+ G++R GD+IL +
Sbjct: 301 EEDIPREPRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSV 359
Query: 1202 NGETTKNMKHSRAIELIKNGGRRVRL 1227
NG +N H +A +KN G+ V +
Sbjct: 360 NGVDLRNASHEQAAIALKNAGQTVTI 385
Score = 73.9 bits (180), Expect = 9e-13
Identities = 66/254 (25%), Positives = 101/254 (39%), Gaps = 63/254 (24%)
Query: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
++ + RG N G GF I P G I +II G A + G+L+V D
Sbjct: 62 EITLERG-NSGLGFSIAGGTDNPHIGDDPSIF-------ITKIIPGGAAAQDGRLRVNDS 113
Query: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
IL VN + +HS V +KEAG+ V L ++
Sbjct: 114 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM--------------------------- 146
Query: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-----N 1172
KP E E K L +G KG GFS+ GG +
Sbjct: 147 ---------RRKPPAEKVMEIK--------------LIKGPKGLGFSIAGGVGNQHIPGD 183
Query: 1173 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1232
+YV ++ E G A + G+++IGD+IL +N +++ H A+ +KN V L + +
Sbjct: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 243
Query: 1233 DGSVPEYAMIPPNI 1246
+ + PP+I
Sbjct: 244 SNAYLSDSYAPPDI 257
Score = 60.8 bits (146), Expect = 8e-09
Identities = 69/284 (24%), Positives = 114/284 (40%), Gaps = 66/284 (23%)
Query: 640 ELITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVN 690
+++ + ++KGP G GF+IA PG V +I++ L+ GD I+ VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 691 KKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVS 750
++ + H V L +V L ++P S + + ++
Sbjct: 214 SVGLEDVMHEDAVAALKNT---YDVVYL------------KVAKPSNAYLSDSYAPPDIT 258
Query: 751 SHRSLHTASP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809
+ S H + SHS+ + ++P A P SP
Sbjct: 259 TSYSQHLDNEISHSSYLGTDYPTAMT------------------------------PTSP 288
Query: 810 SPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGH 869
S ++K GE IP + + I + R TG GF I+GG E GE I+I
Sbjct: 289 RRYSPVAKDL---------LGEEDIPR-EPRRIVIHRGSTGLGFNIVGG-EDGEGIFISF 337
Query: 870 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
I+ G AD G LR GD+++ V+G + SH+ ++ A +
Sbjct: 338 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ 381
Score = 60.5 bits (145), Expect = 1e-08
Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 5/91 (5%)
Query: 1146 EQDFYTVELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDGPAERCGKMRIGDEILE 1200
E ++ + LERG G GFS+ GG + + +++ ++ G A + G++R+ D IL
Sbjct: 57 EMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILF 116
Query: 1201 INGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+N + + HS A+E +K G VRL++ R
Sbjct: 117 VNEVDVREVTHSAAVEALKEAGSIVRLYVMR 147
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/262 (24%), Positives = 102/262 (38%), Gaps = 37/262 (14%)
Query: 469 KFIHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
K + KL K +G GF++ GG D + + ++ G A DG+++ GD I++VN
Sbjct: 154 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 213
Query: 524 DTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIV 583
+ H V ++ V L++ + N L S A D I
Sbjct: 214 SVGLEDVMHEDAVAALKN--TYDVVYLKVAK---------PSNAYLSDSYAPPD---ITT 259
Query: 584 NGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSL--ASSIATQPEL 641
+ + D+ SHSS G P + S Y L I +P
Sbjct: 260 SYSQHLDNEISHSSYLG---------TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR 310
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLKEGDLIVEVNKKNVQALT 698
I +H +G G GF I G G + I+ + L++GD I+ VN +++ +
Sbjct: 311 IVIH--RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 368
Query: 699 HNQVVDMLVECPKGSEVTLLVQ 720
H Q L G VT++ Q
Sbjct: 369 HEQAAIALKNA--GQTVTIIAQ 388
Score = 43.9 bits (102), Expect = 0.001
Identities = 36/129 (27%), Positives = 58/129 (44%), Gaps = 9/129 (6%)
Query: 434 PPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGG-DEP 492
P +PN S P L+ + E++ + I L + + G GF++ GG D P
Sbjct: 26 PAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEI--TLERGNSGLGFSIAGGTDNP 83
Query: 493 ----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASV 548
D + I ++ G AA DG++ D I+ VN+ V TH+ V+ + G+ V
Sbjct: 84 HIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKE--AGSIV 141
Query: 549 DLELCRGYP 557
L + R P
Sbjct: 142 RLYVMRRKP 150
Score = 40.8 bits (94), Expect = 0.008
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR RE E+ G DY+F++ +E ++ + Q+ +E G Y + YGT
Sbjct: 560 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 608
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens]
Length = 767
Score = 89.7 bits (221), Expect = 2e-17
Identities = 110/425 (25%), Positives = 174/425 (40%), Gaps = 105/425 (24%)
Query: 821 EREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNE-----PGEPIYIGHIVPLGA 875
E ++N T GE +Y+E I L R +G GF I GG + I+I I+P GA
Sbjct: 94 ELQVNGTE-GEM---EYEE--ITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGA 147
Query: 876 ADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENE 935
A DGRLR D ++ V+ V +H V+ +++A V L V R+
Sbjct: 148 AAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAG--SIVRLYVMRR----------- 194
Query: 936 VPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ 995
PA E + +G + G+G GG G
Sbjct: 195 -----------KPPAEKVMEIKLIKGPK--------------GLGFSIAGGVG------- 222
Query: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1055
+ G+N + I+ E G HK GR+ ++G
Sbjct: 223 ---NQHIPGDNSIYVTKII------EGGAA---------HKDGRL------------QIG 252
Query: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHT 1115
D+ILAVN + + H D V +K + V L++ + SNA L+++ ITT+++
Sbjct: 253 DKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVA---KPSNA-YLSDSYAPPDITTSYS 308
Query: 1116 ---------PSQQGTQETRNTTKPKQESQFEFKAPQATQEQDF----YTVELERGAKGFG 1162
S GT T P ++ A E+D + + RG+ G G
Sbjct: 309 QHLDNEISHSSYLGTDYPTAMT-PTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLG 367
Query: 1163 FSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGG 1222
F++ GG E +++ + GPA+ G++R GD+IL +NG +N H +A +KN G
Sbjct: 368 FNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAG 426
Query: 1223 RRVRL 1227
+ V +
Sbjct: 427 QTVTI 431
Score = 73.9 bits (180), Expect = 9e-13
Identities = 66/254 (25%), Positives = 101/254 (39%), Gaps = 63/254 (24%)
Query: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
++ + RG N G GF I P G I +II G A + G+L+V D
Sbjct: 108 EITLERG-NSGLGFSIAGGTDNPHIGDDPSIF-------ITKIIPGGAAAQDGRLRVNDS 159
Query: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
IL VN + +HS V +KEAG+ V L ++
Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM--------------------------- 192
Query: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-----N 1172
KP E E K L +G KG GFS+ GG +
Sbjct: 193 ---------RRKPPAEKVMEIK--------------LIKGPKGLGFSIAGGVGNQHIPGD 229
Query: 1173 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1232
+YV ++ E G A + G+++IGD+IL +N +++ H A+ +KN V L + +
Sbjct: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKP 289
Query: 1233 DGSVPEYAMIPPNI 1246
+ + PP+I
Sbjct: 290 SNAYLSDSYAPPDI 303
Score = 65.5 bits (158), Expect = 3e-10
Identities = 34/123 (27%), Positives = 61/123 (49%), Gaps = 5/123 (4%)
Query: 1114 HTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-- 1171
H P+Q + T + +E + E ++ + LERG G GFS+ GG +
Sbjct: 71 HLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPH 130
Query: 1172 ---NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLF 1228
+ +++ ++ G A + G++R+ D IL +N + + HS A+E +K G VRL+
Sbjct: 131 IGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLY 190
Query: 1229 LKR 1231
+ R
Sbjct: 191 VMR 193
Score = 60.8 bits (146), Expect = 8e-09
Identities = 69/284 (24%), Positives = 114/284 (40%), Gaps = 66/284 (23%)
Query: 640 ELITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVN 690
+++ + ++KGP G GF+IA PG V +I++ L+ GD I+ VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 691 KKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVS 750
++ + H V L +V L ++P S + + ++
Sbjct: 260 SVGLEDVMHEDAVAALKNT---YDVVYL------------KVAKPSNAYLSDSYAPPDIT 304
Query: 751 SHRSLHTASP-SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809
+ S H + SHS+ + ++P A P SP
Sbjct: 305 TSYSQHLDNEISHSSYLGTDYPTAMT------------------------------PTSP 334
Query: 810 SPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGH 869
S ++K GE IP + + I + R TG GF I+GG E GE I+I
Sbjct: 335 RRYSPVAKDL---------LGEEDIPR-EPRRIVIHRGSTGLGFNIVGG-EDGEGIFISF 383
Query: 870 IVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
I+ G AD G LR GD+++ V+G + SH+ ++ A +
Sbjct: 384 ILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQ 427
Score = 51.6 bits (122), Expect = 5e-06
Identities = 64/262 (24%), Positives = 102/262 (38%), Gaps = 37/262 (14%)
Query: 469 KFIHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVN 523
K + KL K +G GF++ GG D + + ++ G A DG+++ GD I++VN
Sbjct: 200 KVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVN 259
Query: 524 DTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIV 583
+ H V ++ V L++ + N L S A D I
Sbjct: 260 SVGLEDVMHEDAVAALKN--TYDVVYLKVAK---------PSNAYLSDSYAPPD---ITT 305
Query: 584 NGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSL--ASSIATQPEL 641
+ + D+ SHSS G P + S Y L I +P
Sbjct: 306 SYSQHLDNEISHSSYLG---------TDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRR 356
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLKEGDLIVEVNKKNVQALT 698
I +H +G G GF I G G + I+ + L++GD I+ VN +++ +
Sbjct: 357 IVIH--RGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNAS 414
Query: 699 HNQVVDMLVECPKGSEVTLLVQ 720
H Q L G VT++ Q
Sbjct: 415 HEQAAIALKNA--GQTVTIIAQ 434
Score = 45.1 bits (105), Expect = 4e-04
Identities = 40/151 (26%), Positives = 69/151 (45%), Gaps = 11/151 (7%)
Query: 413 QQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTR-NPSELKGKFI 471
+ Q+ + Q + +HS P +PN S P L+ + + N +E + ++
Sbjct: 51 ESQKYRYQDEDTPPLEHS---PAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYE 107
Query: 472 HTKLRKSSRGFGFTVVGG-DEP----DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
L + + G GF++ GG D P D + I ++ G AA DG++ D I+ VN+
Sbjct: 108 EITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVD 167
Query: 527 VLGHTHAQVVKIFQSIPIGASVDLELCRGYP 557
V TH+ V+ + G+ V L + R P
Sbjct: 168 VREVTHSAAVEALKE--AGSIVRLYVMRRKP 196
Score = 40.8 bits (94), Expect = 0.008
Identities = 20/49 (40%), Positives = 31/49 (63%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR RE E+ G DY+F++ +E ++ + Q+ +E G Y + YGT
Sbjct: 606 VPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGT 654
>gi|29789058 WW and C2 domain containing 1 isoform 3 [Homo sapiens]
Length = 1113
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
Query: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
Query: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Query: 463 PSELKGKFIHT--KLRKSSRGF 482
++LK + +H +L+ RGF
Sbjct: 171 VNKLKREMVHLQHELQFKERGF 192
Score = 38.9 bits (89), Expect = 0.032
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|242247257 WW and C2 domain containing 1 isoform 2 [Homo sapiens]
Length = 1118
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
Query: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
Query: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Query: 463 PSELKGKFIHT--KLRKSSRGF 482
++LK + +H +L+ RGF
Sbjct: 171 VNKLKREMVHLQHELQFKERGF 192
Score = 38.9 bits (89), Expect = 0.032
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|242247251 WW and C2 domain containing 1 isoform 1 [Homo sapiens]
Length = 1119
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/202 (31%), Positives = 98/202 (48%), Gaps = 36/202 (17%)
Query: 301 PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPL--EECEDDEGVHTEELDSE 358
PLPE WE A +G+VY+IDH +TTSW+DPR ++ KPL +C D
Sbjct: 7 PLPEGWEEARDFDGKVYYIDHTNRTTSWIDPR--DRYTKPLTFADCISD----------- 53
Query: 359 LELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQ-------------LEQQQ- 404
ELP GWE+ DP G Y++DH + TQ E+P ++ +R+++ L Q+
Sbjct: 54 -ELPLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQEALSAQKE 112
Query: 405 --QQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRN 462
Q +QQ+ + QQ+ QQ W + V V + S +P E+
Sbjct: 113 IYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDP--EILKAEIATAKSR 170
Query: 463 PSELKGKFIHT--KLRKSSRGF 482
++LK + +H +L+ RGF
Sbjct: 171 VNKLKREMVHLQHELQFKERGF 192
Score = 38.9 bits (89), Expect = 0.032
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 358 ELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
EL LP GWE+ D +YY+DH NR T + +P
Sbjct: 5 ELPLPEGWEEARDFDGKVYYIDHTNRTTSWIDP 37
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 88.6 bits (218), Expect = 4e-17
Identities = 114/541 (21%), Positives = 219/541 (40%), Gaps = 72/541 (13%)
Query: 731 PKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPD 790
P Q + + S Q S S SL + ++++ + + + ++DSS + D
Sbjct: 991 PPPQTVAELVGKPSHQMSRSDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIE--D 1048
Query: 791 PFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFL--WRKE 848
P + + +M+ +SG S + + N I E++I L +K+
Sbjct: 1049 PGQAYVLGMTMH---------SSGNSSSQVPLKENDVLHKRWSIVSSPEREITLVNLKKD 1099
Query: 849 T--GFGFRILGGNEPGE---PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 903
G GF+I+GG + G I+I + P G AD DG L+ GD LI V+ + G SH
Sbjct: 1100 AKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHA 1159
Query: 904 VVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSH---HSSNQPASLTEEKRTPQ 960
++++Q A + + ++ ++ + VP T + + ++ S Q +++ +
Sbjct: 1160 AIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHH 1219
Query: 961 GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP 1020
S+ +L +S S G GG G +S+ + R E+ +S+S+
Sbjct: 1220 WSRGTLRHISENS-----FGPSGGLREGSLSS-------QDSRTES--------ASLSQS 1259
Query: 1021 EAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKE 1080
+ F + + + GSP+ + S T K V +
Sbjct: 1260 QVNGFFASHLGDQTWQESQ--HGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSD 1317
Query: 1081 AGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKA 1140
G++ + AT ++ + TP Q+ + + K F+ +
Sbjct: 1318 RGDS---------DMDEATYSSSQDH-------QTPKQESSSSVNTSNK----MNFKTFS 1357
Query: 1141 PQATQEQDFYTVELERGAKGFGFSL-----RGGREYNM---DLYVLRLAEDGPAERCGKM 1192
+ D + VEL + G S+ +GG ++ +YV + G AE G++
Sbjct: 1358 SSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRI 1417
Query: 1193 RIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDG-SVPEYAMIPPNIAACMR 1251
GD +L +NG + + H +A+E ++N G+ V L L++G + E+ + P +
Sbjct: 1418 HKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSKEHVPVTPQCTLSDQ 1477
Query: 1252 N 1252
N
Sbjct: 1478 N 1478
Score = 83.6 bits (205), Expect = 1e-15
Identities = 144/689 (20%), Positives = 248/689 (35%), Gaps = 138/689 (20%)
Query: 475 LRKSSR-GFGFTVVGGDEP---DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
L+K ++ G GF ++GG++ D + I S+ GPA LDG ++ GD ++SVN + G
Sbjct: 1096 LKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGV 1155
Query: 531 THAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYD 590
+H ++I Q+ P+D VT V KE I
Sbjct: 1156 SHHAAIEILQNA-------------------PED-----VTLVISQPKEKI-----SKVP 1186
Query: 591 SPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGP 650
S H + K K + A +S+ H + T+ HI +
Sbjct: 1187 STPVHLTNEMKNYMKKSSYMQDSAIDSSSKDHHWSRGTLR--------------HISENS 1232
Query: 651 MGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECP 710
G P GG L+EG L + ++ +L+ +QV
Sbjct: 1233 FG--------PSGG---------------LREGSLSSQDSRTESASLSQSQVNGFFAS-- 1267
Query: 711 KGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEF 770
+ T + G P P K+ E N S+ + S + +
Sbjct: 1268 HLGDQTWQESQHGSPSPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDM---- 1323
Query: 771 PPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFG 830
EA D K+ + ++ ++ SP + + E + NS
Sbjct: 1324 --DEATYSSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGIS 1381
Query: 831 ECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELIC 890
+ D + G + G IY+ ++P GAA++DGR+ GD ++
Sbjct: 1382 VTVLFD-----------KGGVNTSVRHGG-----IYVKAVIPQGAAESDGRIHKGDRVLA 1425
Query: 891 VDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP- 949
V+G + G +H+ V+ ++ + H+ L + SP S H P
Sbjct: 1426 VNGVSLEGATHKQAVETLRNTGQVVHLLL--------------EKGQSPTSKEHVPVTPQ 1471
Query: 950 ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN-EG 1008
+L+++ QG + T S V + E++ +N G
Sbjct: 1472 CTLSDQNAQGQGPEKVKKTTQVKD----------------YSFVTEENTFEVKLFKNSSG 1515
Query: 1009 FGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITN 1068
GF S SR + A ++ ++ G PA GK+ VGD IL VNG S+
Sbjct: 1516 LGF----SFSRED--NLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASLKG 1569
Query: 1069 KSHSDIVNLIKEAGNTVTL---RIIPGD-ESSNATLLTNAEKIATI--TTTHTPSQQGTQ 1122
S ++++ ++ V L R PG + LLT + A + ++ SQ
Sbjct: 1570 LSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCV 1629
Query: 1123 ETRNTTKPKQESQFEFKAPQATQEQDFYT 1151
E ++ + S K ++ +D Y+
Sbjct: 1630 EQSTSSDENEMSDKSKKQCKSPSRRDSYS 1658
Score = 71.2 bits (173), Expect = 6e-12
Identities = 72/299 (24%), Positives = 129/299 (43%), Gaps = 38/299 (12%)
Query: 951 SLTEEKRTP-QGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGF 1009
S +++ +TP Q S +S+NT + + T G ++VE+ + +N
Sbjct: 1329 SSSQDHQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDI---------FEVELAKNDNS-L 1378
Query: 1010 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNK 1069
G + + T+ + + + +I A+ G++ GDR+LAVNG S+
Sbjct: 1379 GISVTVLFDKGGVNTSVRHGGIY----VKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGA 1434
Query: 1070 SHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQ-QGTQETRNTT 1128
+H V ++ G V L + ++ + T + T + +Q QG ++ + TT
Sbjct: 1435 THKQAVETLRNTGQVVHLLL---EKGQSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTT 1491
Query: 1129 KPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--------LYVLRL 1180
+ K S E++ + V+L + + G GFS RE N+ + V +L
Sbjct: 1492 QVKDYS--------FVTEENTFEVKLFKNSSGLGFSF--SREDNLIPEQINASIVRVKKL 1541
Query: 1181 AEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR-GDGSVPE 1238
PA GK+ +GD IL++NG + K + I ++ V L L R G +PE
Sbjct: 1542 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPE 1600
Score = 57.8 bits (138), Expect = 7e-08
Identities = 107/455 (23%), Positives = 174/455 (38%), Gaps = 113/455 (24%)
Query: 474 KLRKSSRGFGFTVVGGDE--PDEF----LQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
KL K+S G GF+ D P++ +++K L PAA GK++ GDVI+ VN +
Sbjct: 1508 KLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGASL 1567
Query: 528 LGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQE 587
G + +V+ + V L LCR P P + +T+L+T + ++ N +
Sbjct: 1568 KGLSQQEVISALRG--TAPEVFLLLCR--PPPGVLPEIDTALLT--PLQSPAQVLPNSSK 1621
Query: 588 TYDSPA----SHSSKTGKVNGMKDARPSSPA--DVASNSSHGYPNDTVSLASSIATQPEL 641
P+ S SS +++ + SP+ D S+SS +D V+ ++I+
Sbjct: 1622 DSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLVTAPANISNSTWS 1681
Query: 642 ITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQ 701
+H Q + +V QA +H+
Sbjct: 1682 SALH--------------------QTLSNMVS---------------------QAQSHH- 1699
Query: 702 VVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPS 761
E PK E T+ P+K P E S
Sbjct: 1700 ------EAPKSQEDTICTM---FYYPQKIPNKPEFE----------------------DS 1728
Query: 762 HSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSR-SMYEN-RPMSPSPASGLSKGE 819
+ + + P+ P ++ P Q++S+ D + I S + EN P+ + L E
Sbjct: 1729 NPSPLPPDMAPGQSYQP-QSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFE 1787
Query: 820 REREINSTNFGECPIPDYQEQDIFLWRKETG-FGFRILGGNEPGEPIYIGHIVPLGAADT 878
E E+ T L + E G GF + GN+ Y+ H V A +
Sbjct: 1788 LEVELLIT----------------LIKSEKGSLGFTVTKGNQ-RIGCYV-HDVIQDPAKS 1829
Query: 879 DGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
DGRL+ GD LI V+ T V +H V L++ A+K
Sbjct: 1830 DGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASK 1864
Score = 47.4 bits (111), Expect = 9e-05
Identities = 22/45 (48%), Positives = 30/45 (66%)
Query: 1045 PADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089
PA G+LK GDR++ VN +TN +H+D VNL++ A TV L I
Sbjct: 1826 PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVI 1870
Score = 47.0 bits (110), Expect = 1e-04
Identities = 31/108 (28%), Positives = 59/108 (54%), Gaps = 8/108 (7%)
Query: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211
++ E+G+ GF++ G + + YV + +D PA+ G+++ GD ++++N NM H
Sbjct: 1797 IKSEKGS--LGFTVTKGNQ-RIGCYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTH 1852
Query: 1212 SRAIELIKNGGRRVRLFLKRGDGSVPEYAMIP---PNIAACMRNEKLG 1256
+ A+ L++ + VRL + R +P M+P P+I E+LG
Sbjct: 1853 TDAVNLLRAASKTVRLVIGR-VLELPRIPMLPHLLPDITLTCNKEELG 1899
Score = 43.5 bits (101), Expect = 0.001
Identities = 55/247 (22%), Positives = 92/247 (37%), Gaps = 34/247 (13%)
Query: 376 YYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPP 435
YY I K ++E+ L Q Q Q + +++ H +
Sbjct: 1714 YYPQKIPNKPEFED-----SNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHIS---- 1764
Query: 436 VIPNHPPSNPEPARE---VPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP 492
EP R+ PL+ EL+ + + T ++ GFTV G++
Sbjct: 1765 ----------EPTRQENWTPLKNDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQR 1814
Query: 493 DEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLEL 552
+ ++ D PA DG+++ GD ++ VNDT V TH V + ++ +V L +
Sbjct: 1815 IG-CYVHDVIQD-PAKSDGRLKPGDRLIKVNDTDVTNMTHTDAVNLLRA--ASKTVRLVI 1870
Query: 553 CRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSS 612
R LP P P+ +L + N +E S +V + D P S
Sbjct: 1871 GRVLELPRIPMLPH--------LLPDITLTCNKEELGFSLCGGHDSLYQVVYISDINPRS 1922
Query: 613 PADVASN 619
A + N
Sbjct: 1923 VAAIEGN 1929
>gi|153070254 MAGI family member, X-linked isoform b [Homo sapiens]
Length = 262
Score = 87.4 bits (215), Expect = 8e-17
Identities = 42/94 (44%), Positives = 65/94 (69%), Gaps = 2/94 (2%)
Query: 1140 APQATQEQDFYTVELERGAKGFGFSLRGGREYNMD--LYVLRLAEDGPAERCGKMRIGDE 1197
AP+ +Q ++VEL RG GFG +L GGR+ D L V L +DGPA+RCG++ +GD
Sbjct: 47 APKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDL 106
Query: 1198 ILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+L INGE+T+ + H++A+E I+ GG ++ L ++R
Sbjct: 107 VLHINGESTQGLTHAQAVERIRAGGPQLHLVIRR 140
Score = 55.5 bits (132), Expect = 3e-07
Identities = 38/114 (33%), Positives = 55/114 (48%), Gaps = 7/114 (6%)
Query: 454 QGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP--DEFLQIKSLVLDGPAALDG 511
QGK PS+ G F +L + GFG T+ GG + D L ++ L+ DGPA G
Sbjct: 41 QGKARSAPKPSQASGHF-SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCG 99
Query: 512 KMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDP 565
++E GD+++ +N G THAQ V+ ++ L L PL P P
Sbjct: 100 RLEVGDLVLHINGESTQGLTHAQAVERIRA----GGPQLHLVIRRPLETHPGKP 149
Score = 48.9 bits (115), Expect = 3e-05
Identities = 40/158 (25%), Positives = 65/158 (41%), Gaps = 31/158 (19%)
Query: 997 YDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGD 1056
+ VE+ RG GFG + R AG T P + +++ PA RCG+L+VGD
Sbjct: 57 FSVELVRGY-AGFGLTLGGG--RDVAGDT--------PLAVRGLLKDGPAQRCGRLEVGD 105
Query: 1057 RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI--------------------IPGDESS 1096
+L +NG S +H+ V I+ G + L I +
Sbjct: 106 LVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDP 165
Query: 1097 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQES 1134
+T + +T H PS+ ++TR + +P E+
Sbjct: 166 GGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEA 203
Score = 46.2 bits (108), Expect = 2e-04
Identities = 52/184 (28%), Positives = 83/184 (45%), Gaps = 30/184 (16%)
Query: 643 TVHIVKGPMGFGFTIA---DSPGGGGQRVKQIV-DSP--RCRGLKEGDLIVEVNKKNVQA 696
+V +V+G GFG T+ D G V+ ++ D P RC L+ GDL++ +N ++ Q
Sbjct: 58 SVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPAQRCGRLEVGDLVLHINGESTQG 117
Query: 697 LTHNQVVDMLVECPKGSEVTLLVQR---------GGLPVPKK----SPKSQPLERKDSQN 743
LTH Q V+ + G ++ L+++R G+ P+K SP E S++
Sbjct: 118 LTHAQAVERI--RAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVDRSPDPGGPEVTGSRS 175
Query: 744 SSQHSVSSHRSLHT-----ASPSHSTQVLPEFP---PAEAQAPDQTDSSGQKKPDPFKIW 795
SS V S T SP S + + P P E +A D D P P+ +
Sbjct: 176 SSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQI-PGSPGPWLVP 234
Query: 796 AQSR 799
++ R
Sbjct: 235 SEER 238
>gi|156546890 WW and C2 domain containing 2 [Homo sapiens]
Length = 1192
Score = 87.4 bits (215), Expect = 8e-17
Identities = 51/135 (37%), Positives = 71/135 (52%), Gaps = 21/135 (15%)
Query: 291 LPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLE--ECEDDE 348
+P A PLP WE A +G+V++IDHNT+ TSW+DPR ++ KPL +C D
Sbjct: 1 MPRRAGSGQLPLPRGWEEARDYDGKVFYIDHNTRRTSWIDPR--DRLTKPLSFADCVGD- 57
Query: 349 GVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQ 408
ELP GWE DP G+YY+DHIN+ TQ E+P RK+ +Q++ +
Sbjct: 58 -----------ELPWGWEAGFDPQIGVYYIDHINKTTQIEDP-----RKQWRGEQEKMLK 101
Query: 409 QQQQQQQQQQQQQTE 423
Q + Q E
Sbjct: 102 DYLSVAQDALRTQKE 116
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 85.9 bits (211), Expect = 2e-16
Identities = 67/228 (29%), Positives = 93/228 (40%), Gaps = 38/228 (16%)
Query: 215 KQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEMNSSFTADS--GEQEEHTLQETALPPVN 272
+QS R++ ++N+G N +D P + S G + P N
Sbjct: 209 EQSPGARSRHRQPVKNSGHSGLANGTVNDEPTTATDPEEPSVVGVTSPPAAPLSVTPNPN 268
Query: 273 SSIIAAPIT-----DPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTS 327
++ + AP T +PS Q LP +A+ LP WE NG VY++DHNTKTT+
Sbjct: 269 TTSLPAPATPAEGEEPSTSGTQQLPAAAQAP-DALPAGWEQRELPNGRVYYVDHNTKTTT 327
Query: 328 WLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQY 387
W E LP GWEK DP YYVDH R T +
Sbjct: 328 W-----------------------------ERPLPPGWEKRTDPRGRFYYVDHNTRTTTW 358
Query: 388 ENPVLEAKRK-KQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVP 434
+ P E R +Q + Q+ Q Q Q Q+ Q+ + DH L P
Sbjct: 359 QRPTAEYVRNYEQWQSQRNQLQGAMQHFSQRFLYQSSSASTDHDPLGP 406
Score = 63.9 bits (154), Expect = 9e-10
Identities = 35/94 (37%), Positives = 46/94 (48%), Gaps = 20/94 (21%)
Query: 297 DNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELD 356
D LGPLP WE +NG VY+++HNT+TT W DPR T+ +
Sbjct: 402 DPLGPLPPGWEKRQ-DNGRVYYVNHNTRTTQWEDPR-------------------TQGMI 441
Query: 357 SELELPAGWEKIEDPVYGIYYVDHINRKTQYENP 390
E LP GWE Y+VDH R T +++P
Sbjct: 442 QEPALPPGWEMKYTSEGVRYFVDHNTRTTTFKDP 475
Score = 48.5 bits (114), Expect = 4e-05
Identities = 19/31 (61%), Positives = 23/31 (74%)
Query: 302 LPENWEMAYTENGEVYFIDHNTKTTSWLDPR 332
LP WEM YT G YF+DHNT+TT++ DPR
Sbjct: 446 LPPGWEMKYTSEGVRYFVDHNTRTTTFKDPR 476
>gi|223890252 glutamate receptor interacting protein 1 [Homo sapiens]
Length = 1076
Score = 83.6 bits (205), Expect = 1e-15
Identities = 169/829 (20%), Positives = 290/829 (34%), Gaps = 140/829 (16%)
Query: 426 TEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFT 485
T+D S PP R + P E KG + ++K G T
Sbjct: 17 TKDESPYTKSASQTKPPDGALAVRRQSI---------PEEFKGSTVVELMKKEGTTLGLT 67
Query: 486 VVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIG 545
V GG + D ++ +L G AA +++ GD I +VN + H +++ + +++ G
Sbjct: 68 VSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNV--G 125
Query: 546 ASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEP----IIVNGQETYDS---------- 591
V LE+ P P + T L KE ++ G D
Sbjct: 126 ERVVLEVEYELP-PVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITC 184
Query: 592 --PASHSSKTGKVN--------------GMKDARPSSPADVASNSSHGYPNDTVSLASSI 635
P + + G + G A S + VS+ S+
Sbjct: 185 VRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSV 244
Query: 636 ATQPELITVHIVKGP-MGFGFTIADSPGGGGQ-----RVKQIVDSPRCRGLKEGDLIVEV 689
AT + V + K P G + S Q ++K + RC L GD I+ +
Sbjct: 245 ATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSI 304
Query: 690 NKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSV 749
+ +++ T + L ++ +L P Q
Sbjct: 305 DGTSMEYCTLAEATQFLANTTDQVKLEIL------------PHHQT-------------- 338
Query: 750 SSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809
L P H+ V F P A + + P RS+Y P
Sbjct: 339 ----RLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLP---------RSLYSTSPRGT 385
Query: 810 SPASGLSKGEREREIN--STNFGECPIPDYQEQDIFLWRKE--TGFGFRILGGNEPGE-- 863
L K + + ++ S+ G + E + + TGFG ++ G E
Sbjct: 386 MMRRRLKKKDFKSSLSLASSTVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATETL 445
Query: 864 --PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV 921
P I +I A+ G L+ GD ++ ++G P + + QL++ ++ V L +
Sbjct: 446 SSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEI 505
Query: 922 RRKVVFAV-----------PKTENEVPSPASSHHSSNQPASLTEEKRTPQGS-QNSLNTV 969
V +V PK N S SS +P +GS + T+
Sbjct: 506 EFDVAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTL 565
Query: 970 SSGSG--STSGIGSGGGGGSGVVSTVVQPYDV---EIRRGEN-----EGFGFVIVSSVSR 1019
G + I V + Q D+ +IR+ E+ E G +I + +
Sbjct: 566 ELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELK 625
Query: 1020 PEAG----TTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1075
G T G P I + +G A+R G + +GDRILA+N S+ K S+ +
Sbjct: 626 RYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAI 685
Query: 1076 NLIKEAGNTVTLRIIPGDESSNAT------LLTNAEKIATITTTHTPSQQ--GTQETRNT 1127
+L++ AG TVTL+I ++ +A+ + ++ + + +P+Q+ + +
Sbjct: 686 HLLQMAGETVTLKIKKQTDAQSASSPKKFPISSHLSDLGDVEEDSSPAQKPGKLSDMYPS 745
Query: 1128 TKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLY 1176
T P +S A D ++ G +G F G YN + Y
Sbjct: 746 TVPSVDS--------AVDSWDGSAIDTSYGTQGTSFQASG---YNFNTY 783
Score = 79.7 bits (195), Expect = 2e-14
Identities = 97/433 (22%), Positives = 159/433 (36%), Gaps = 75/433 (17%)
Query: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 924
I I I AD G L GD ++ +DGT + + Q + Q + + +
Sbjct: 278 IVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQ 337
Query: 925 VVFAVPKTENEVPSPASSHHSSNQPASLTE----------EKRTPQGSQNSLNTVSSGSG 974
A+ ++ +S +S SL+ +P+G+
Sbjct: 338 TRLALKGPDHAALVSSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFK 397
Query: 975 STSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMP 1034
S+ + S G +G V + +V + GFG + SV F ++ P
Sbjct: 398 SSLSLASSTVGLAGQV-VHTETTEVVLTADPVTGFGIQLQGSV--------FATETLSSP 448
Query: 1035 HKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLR---- 1088
I I SPA+RCG L++GDR++A+NG + + + L++++ T VTL
Sbjct: 449 PLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLEIEFD 508
Query: 1089 ----IIPGDESSNATLLTNAEKIATITTTHTPSQQ-------------------GT---- 1121
+IP + + L IT + S++ GT
Sbjct: 509 VAESVIPSSGTFHVKLPKKHNVELGITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELG 568
Query: 1122 -----------------------QETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGA 1158
Q+ + K K + Q + YTVEL+R
Sbjct: 569 DKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSDEQESSGAIIYTVELKRYG 628
Query: 1159 KGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
G ++ G E + + L + G AER G + IGD IL IN + K S AI L+
Sbjct: 629 GPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEAIHLL 688
Query: 1219 KNGGRRVRLFLKR 1231
+ G V L +K+
Sbjct: 689 QMAGETVTLKIKK 701
Score = 73.2 bits (178), Expect = 2e-12
Identities = 96/443 (21%), Positives = 166/443 (37%), Gaps = 70/443 (15%)
Query: 844 LWRKE-TGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQ 902
L +KE T G + GG + + ++ G A +L GD + V+G + H
Sbjct: 56 LMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHD 115
Query: 903 LVVQLMQQAAKQGHVNL-------------TVRRKVVFAVPKTENE----VPSPASSHHS 945
++ L++ ++ + + + R V + K N + A +
Sbjct: 116 EIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFVIRGGAHDDRN 175
Query: 946 SNQPASLTEEKRTPQGSQNSLNTVSSGSG--STSGIGSGGGGGSGVVSTVVQ-------- 995
++P +T + P G + T+ G S GI G + +S + Q
Sbjct: 176 KSRPVVITCVR--PGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAALL 233
Query: 996 -PYDVEIRRGENEGFGFVIVSSVSRPEAGT----TFGNACVAMPHKIGRIIEGSPADRCG 1050
YDV + G ++V P A T C I +I S ADRCG
Sbjct: 234 IEYDVSVMDSVATASGPLLVEVAKTPGASLGVALTTSMCCNKQVIVIDKIKSASIADRCG 293
Query: 1051 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATI 1110
L VGD IL+++G S+ + ++ + + V L I+P ++ A L + A +
Sbjct: 294 ALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKLEILPHHQTRLA--LKGPDHAALV 351
Query: 1111 TTTHTP-----------------------SQQGTQETRNTTKPKQESQFEFK------AP 1141
+++ +P S +GT R K +S A
Sbjct: 352 SSSFSPTSMSAYSLSSLNMGTLPRSLYSTSPRGTMMRRRLKKKDFKSSLSLASSTVGLAG 411
Query: 1142 QATQEQDFYTVELERGAKGFGFSLRGG----REYNMDLYVLRLAEDGPAERCGKMRIGDE 1197
Q + V GFG L+G + + + D PAERCG ++IGD
Sbjct: 412 QVVHTETTEVVLTADPVTGFGIQLQGSVFATETLSSPPLISYIEADSPAERCGVLQIGDR 471
Query: 1198 ILEINGETTKNMKHSRAIELIKN 1220
++ ING T++ A +L+++
Sbjct: 472 VMAINGIPTEDSTFEEASQLLRD 494
Score = 58.9 bits (141), Expect = 3e-08
Identities = 47/204 (23%), Positives = 83/204 (40%), Gaps = 56/204 (27%)
Query: 1036 KIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDES 1095
++ + +G A R +L VGD I AVNG ++ H +I++L+K G V L +
Sbjct: 79 RVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKNVGERVVLEV------ 132
Query: 1096 SNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQD---FYTV 1152
E++ P + + F TV
Sbjct: 133 -----------------------------------------EYELPPVSVQGSSVIFRTV 151
Query: 1153 ELERGAKG--FGFSLRGG----REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETT 1206
E+ +G FGF +RGG R + + + + GPA+R G ++ GD +L ++G
Sbjct: 152 EVTLHKEGNTFGFVIRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRL 211
Query: 1207 KNMKHSRAIELIKNGGRRVRLFLK 1230
H+ A+ ++K G+ L ++
Sbjct: 212 LGTTHAEAMSILKQCGQEAALLIE 235
Score = 50.8 bits (120), Expect = 8e-06
Identities = 53/238 (22%), Positives = 96/238 (40%), Gaps = 53/238 (22%)
Query: 991 STVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCG 1050
S + + +V + + E FGFVI G + + P I + G PADR G
Sbjct: 145 SVIFRTVEVTLHK-EGNTFGFVI--------RGGAHDDRNKSRPVVITCVRPGGPADREG 195
Query: 1051 KLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATI 1110
+K GDR+L+V+G + +H++ ++++K+ G L +I D S ++ T + +
Sbjct: 196 TIKPGDRLLSVDGIRLLGTTHAEAMSILKQCGQEAAL-LIEYDVSVMDSVATASGPLLVE 254
Query: 1111 TTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGRE 1170
K P A+ G +L
Sbjct: 255 VA--------------------------KTPGAS----------------LGVALTTSMC 272
Query: 1171 YNMDLYVL-RLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1227
N + V+ ++ A+RCG + +GD IL I+G + + + A + + N +V+L
Sbjct: 273 CNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQVKL 330
Score = 41.6 bits (96), Expect = 0.005
Identities = 33/127 (25%), Positives = 52/127 (40%), Gaps = 12/127 (9%)
Query: 1101 LTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG 1160
LT E T + + T G R + P+ EFK + +++
Sbjct: 16 LTKDESPYTKSASQTKPPDGALAVRRQSIPE-----EFKGSTVVEL-------MKKEGTT 63
Query: 1161 FGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
G ++ GG + + V L + G A R ++ +GD I +NG +H I L+KN
Sbjct: 64 LGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGINLAKFRHDEIISLLKN 123
Query: 1221 GGRRVRL 1227
G RV L
Sbjct: 124 VGERVVL 130
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 83.6 bits (205), Expect = 1e-15
Identities = 112/474 (23%), Positives = 185/474 (39%), Gaps = 95/474 (20%)
Query: 634 SIATQPELITVHIVKGPMGFGFTIADSPGGG--GQRVKQIVDSPRCRG---LKEGDLIVE 688
S+ +L+ V GP+G + GG G VK++ + +E D IV
Sbjct: 267 SLDDMVKLVEVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVR 326
Query: 689 VNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERK--------- 739
+N +++ Q M + + T ++ +P K Q + +
Sbjct: 327 INDGDLRNRRFEQAQHMFRQAMR----TPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRF 382
Query: 740 --DSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQ 797
DSQ SV+S LHT + PE + ++ P SG+ P
Sbjct: 383 SPDSQYIDNRSVNS-AGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAP------ 435
Query: 798 SRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRI-- 855
+ S + +SG + + + +N I L + G GF I
Sbjct: 436 --ASAPQNVFSTTVSSGYNTKKIGKRLN----------------IQLKKGTEGLGFSITS 477
Query: 856 ----LGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQA 911
+GG+ P IY+ +I+P GAA DGRL++GD LI V+G ++GKS + VV L++
Sbjct: 478 RDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRST 534
Query: 912 AKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN-TVS 970
+G V+L V R+ P+ N PS + A + TP G++ L V
Sbjct: 535 KMEGTVSLLVFRQEDAFHPRELNAEPSQMQIPKETK--AEDEDIVLTPDGTREFLTFEVP 592
Query: 971 SGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNAC 1030
++G+G G R EN + V S
Sbjct: 593 LNDSGSAGLGVSVKGN---------------RSKENHADLGIFVKS-------------- 623
Query: 1031 VAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT 1084
II G A + G+L+V D+++AVNG S+ K++ D + ++ + +T
Sbjct: 624 ---------IINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMST 668
Score = 76.6 bits (187), Expect = 1e-13
Identities = 75/291 (25%), Positives = 133/291 (45%), Gaps = 59/291 (20%)
Query: 939 PASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYD 998
P S+H S P++ QN +T S +T IG + +
Sbjct: 422 PHSAHPSGKPPSA------PASAPQNVFSTTVSSGYNTKKIG--------------KRLN 461
Query: 999 VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058
+++++G EG GF I S T G + P + I+ A + G+LK GDR+
Sbjct: 462 IQLKKG-TEGLGFSITSR------DVTIGGSA---PIYVKNILPRGAAIQDGRLKAGDRL 511
Query: 1059 LAVNGCSITNKSHSDIVNLIK--EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTP 1116
+ VNG + KS ++V+L++ + TV+L + +++ + L NAE P
Sbjct: 512 IEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPREL-NAE----------P 560
Query: 1117 SQ-QGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVEL---ERGAKGFGFSLRGGR--- 1169
SQ Q +ET K E + P T+E F T E+ + G+ G G S++G R
Sbjct: 561 SQMQIPKET------KAEDEDIVLTPDGTRE--FLTFEVPLNDSGSAGLGVSVKGNRSKE 612
Query: 1170 -EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1219
++ ++V + G A + G++R+ D+++ +NGE+ + A+E ++
Sbjct: 613 NHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
Score = 59.7 bits (143), Expect = 2e-08
Identities = 131/576 (22%), Positives = 208/576 (36%), Gaps = 165/576 (28%)
Query: 417 QQQQQTEEWTEDHSALVPPV---------IPNHPPSNPEPAREVPLQGKPFFTRNPSELK 467
++Q+Q E+ TE+ ++ V PV IPN + EVP G P
Sbjct: 234 EKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVEVPNDGGPL--------- 284
Query: 468 GKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV 527
G + + R G L +K L G A + D IV +ND +
Sbjct: 285 GIHVVPFSARGGRTLG------------LLVKRLEKGGKAEHENLFRENDCIVRINDGDL 332
Query: 528 LGHTHAQVVKIFQS-----------IPIGASVDLELCRG------YPLPFDPDDP--NTS 568
Q +F+ +P E Y F PD +
Sbjct: 333 RNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNR 392
Query: 569 LVTSVAI--LDKEPIIVNGQETYDSPAS--HSSK-TGKVNGMKDARPSSPADVASNSSHG 623
V S + + + P + + E DS + HS+ +GK PS+PA N
Sbjct: 393 SVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKP-------PSAPASAPQNVF-- 443
Query: 624 YPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRG---- 679
+ TVS + + + + + KG G GF+I G V + RG
Sbjct: 444 --STTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQ 501
Query: 680 ---LKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
LK GD ++EVN ++ + +VV +L V+LLV R
Sbjct: 502 DGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFR--------------- 546
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQT---DSSGQKKPDPFK 793
Q R L+ A PS Q+ P E +A D+ G ++ F+
Sbjct: 547 ---------QEDAFHPRELN-AEPSQM-QI-----PKETKAEDEDIVLTPDGTREFLTFE 590
Query: 794 IWAQSRSMYENRPMSPSPASGLS---KGEREREINSTNFGECPIPDYQEQDIFLWRKETG 850
+ P++ S ++GL KG R +E N + G
Sbjct: 591 V-----------PLNDSGSAGLGVSVKGNRSKE-NHADLG-------------------- 618
Query: 851 FGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 910
I++ I+ GAA DGRLR D+LI V+G ++GK++Q ++ +++
Sbjct: 619 --------------IFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRR 664
Query: 911 AA-----KQGHVNLTVRRKVVFAVPKTENEVPSPAS 941
+ K+G + L V R++ NE+ SP S
Sbjct: 665 SMSTEGNKRGMIQLIVARRI-----SKCNELKSPGS 695
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/148 (25%), Positives = 72/148 (48%), Gaps = 11/148 (7%)
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPN-HPPSNPEPAREVPLQGKPFFTRNPSELKGKFIH 472
Q+ + E + HS L P+ PPS P A + N ++ GK ++
Sbjct: 403 QRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKI-GKRLN 461
Query: 473 TKLRKSSRGFGFTV------VGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
+L+K + G GF++ +GG P + +K+++ G A DG+++ GD ++ VN
Sbjct: 462 IQLKKGTEGLGFSITSRDVTIGGSAP---IYVKNILPRGAAIQDGRLKAGDRLIEVNGVD 518
Query: 527 VLGHTHAQVVKIFQSIPIGASVDLELCR 554
++G + +VV + +S + +V L + R
Sbjct: 519 LVGKSQEEVVSLLRSTKMEGTVSLLVFR 546
Score = 39.3 bits (90), Expect = 0.025
Identities = 39/234 (16%), Positives = 87/234 (37%), Gaps = 53/234 (22%)
Query: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNT--VTLRIIPGDE 1094
+ R+ +G A+ + D I+ +N + N+ ++ ++A T + ++P
Sbjct: 303 VKRLEKGGKAEHENLFRENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAAN 362
Query: 1095 SSNATLLTNAEKIATITTTHTPSQQ-------------GTQETRNTTKPKQESQFEFKAP 1141
L+ +EK ++ +P Q Q P ++ + P
Sbjct: 363 KEQYEQLSQSEKNNYYSSRFSPDSQYIDNRSVNSAGLHTVQRAPRLNHPPEQIDSHSRLP 422
Query: 1142 Q------------ATQEQDFYT-----------------VELERGAKGFGFSLR------ 1166
A+ Q+ ++ ++L++G +G GFS+
Sbjct: 423 HSAHPSGKPPSAPASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTI 482
Query: 1167 GGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKN 1220
GG + +YV + G A + G+++ GD ++E+NG + L+++
Sbjct: 483 GG---SAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRS 533
Score = 37.0 bits (84), Expect = 0.12
Identities = 35/154 (22%), Positives = 63/154 (40%), Gaps = 21/154 (13%)
Query: 479 SRGFGFTVVGG----DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
S G G +V G + D + +KS++ G A+ DG++ D +++VN +LG T+
Sbjct: 598 SAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQD 657
Query: 535 VVKIFQ-----------SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPII- 582
++ + I + + + C P P P + T A+ D+E I
Sbjct: 658 AMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPPGPELPIET--ALDDRERRIS 715
Query: 583 ---VNGQETYDSPASHSSKTGKVNGMKDARPSSP 613
+G E D S ++ ++ G SP
Sbjct: 716 HSLYSGIEGLDESPSRNAALSRIMGESGKYQLSP 749
Score = 31.6 bits (70), Expect = 5.1
Identities = 21/76 (27%), Positives = 40/76 (52%), Gaps = 15/76 (19%)
Query: 400 LEQQQQQQQQQQQQQQQQQQQQTEEWTEDHS--------ALVPPVIP---NHPPSNPEPA 448
LE Q+ +Q+Q++++QQ ++Q E ++ + PP P + PPS + A
Sbjct: 1281 LETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAPPKGPFRQDVPPSPSQVA 1340
Query: 449 R----EVPLQGKPFFT 460
R + P +G+PF++
Sbjct: 1341 RLNRLQTPEKGRPFYS 1356
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 83.2 bits (204), Expect = 1e-15
Identities = 58/204 (28%), Positives = 89/204 (43%), Gaps = 18/204 (8%)
Query: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1096
I R+ E PA R G ++VGD++L VNG ++ H + V ++ AG V +R+
Sbjct: 760 ISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVW------ 812
Query: 1097 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELER 1156
+ E TIT +E R E P + + L R
Sbjct: 813 -RERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQR----HVACLAR 867
Query: 1157 GAKGFGFSLRGG------REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1210
+G GFS+ GG R + ++V R+AE G A R G +++GD +L ING +
Sbjct: 868 SERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 1211 HSRAIELIKNGGRRVRLFLKRGDG 1234
H A+ L+ + L L+R G
Sbjct: 928 HDHAVSLLTAASPTIALLLEREAG 951
Score = 80.9 bits (198), Expect = 7e-15
Identities = 98/420 (23%), Positives = 161/420 (38%), Gaps = 79/420 (18%)
Query: 838 QEQDIFLWRKETGFGFRILGGNEP------GEPIYIGHIVPLGAADTDGRLRSGDELICV 891
+E + + R+ G G I GG E I+I + G A G +R GD+L+ V
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 892 DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV-----VFAVPKTENEVPSPASSHHSS 946
+G + G H V+ ++ A + + R V V P + SP
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
Query: 947 NQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006
+ L E P ++ V+ + S G+G GG G PY R G+
Sbjct: 844 LRLPLLPPESPGPLRQRH----VACLARSERGLGFSIAGGKGST-----PY----RAGDA 890
Query: 1007 EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSI 1066
F + RI EG A R G L+VGDR+L++NG +
Sbjct: 891 GIF---------------------------VSRIAEGGAAHRAGTLQVGDRVLSINGVDV 923
Query: 1067 TNKSHSDIVNLIKEAGNTVTLRI-------IPGDESSNATLLTNAEKIATITTTHTPSQQ 1119
T H V+L+ A T+ L + +P +++ T A +ITT TP
Sbjct: 924 TEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTA-TPGVP 982
Query: 1120 GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNM------ 1173
G + + P +E + L R G S+ GG +++
Sbjct: 983 GLPSLAPSLLAA-----ALEGPYPVEE-----IRLPRAGGPLGLSIVGGSDHSSHPFGVQ 1032
Query: 1174 --DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+++ ++ G A R G +R+GD IL +NG+ ++ H A+ + + L ++R
Sbjct: 1033 EPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
Score = 72.8 bits (177), Expect = 2e-12
Identities = 131/594 (22%), Positives = 226/594 (38%), Gaps = 105/594 (17%)
Query: 681 KEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSE----VTLLVQRGGLPVPKKSPKSQPL 736
KEG + V+ +V+ ++ +Q ++L+E + E +T+L Q GGL + K
Sbjct: 694 KEGAV---VSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTP 750
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDS----SGQKKPDPF 792
+ D + VS A ++L E Q + ++ G
Sbjct: 751 YKGDDEGIFISRVSEEGPAARAGVRVGDKLL-EVNGVALQGAEHHEAVEALRGAGTAVQM 809
Query: 793 KIWAQSRSMYENR----PMSPSPASGLSKGEREREINSTNFG----ECPIPDYQEQDIFL 844
++W + EN P+ P RER E P P Q L
Sbjct: 810 RVWRERMVEPENAVTITPLRPED----DYSPRERRGGGLRLPLLPPESPGPLRQRHVACL 865
Query: 845 WRKETGFGFRILGGN-----EPGEP-IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIG 898
R E G GF I GG G+ I++ I GAA G L+ GD ++ ++G V
Sbjct: 866 ARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
Query: 899 KSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRT 958
H V L+ A+ + L + R+ +P PSP HSS A++
Sbjct: 926 ARHDHAVSLLTAASPT--IALLLEREAGGPLP------PSPLP--HSSPPTAAV------ 969
Query: 959 PQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEG--FGFVIVSS 1016
+ S+ T + G + S + + + PY VE R G G IV
Sbjct: 970 ---ATTSITTATPGVPGLPSLAP-----SLLAAALEGPYPVEEIRLPRAGGPLGLSIVG- 1020
Query: 1017 VSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1075
+ FG V P I +++ A R G L+VGDRILAVNG + + +H + V
Sbjct: 1021 -GSDHSSHPFG---VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAV 1075
Query: 1076 NLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ 1135
+ + ++L + P+ G +E P +
Sbjct: 1076 SALLRPCLELSLLV-----------------------RRDPAPPGLRELCIQKAPGER-- 1110
Query: 1136 FEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIG 1195
+ + GA+G + R + +++ +++ G A R G++R+G
Sbjct: 1111 --------------LGISIRGGARGHAGNPRDPTDEG--IFISKVSPTGAAGRDGRLRVG 1154
Query: 1196 DEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG-DGSVPEYAMIPPNIAA 1248
+LE+N ++ + H A++L+++ G + + + G + S + P + A
Sbjct: 1155 LRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIA 1208
Score = 63.9 bits (154), Expect = 9e-10
Identities = 109/573 (19%), Positives = 205/573 (35%), Gaps = 110/573 (19%)
Query: 393 EAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVP 452
E + +++ Q+++++++++ + ++++ TEE ++ + + P + + V
Sbjct: 660 EEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSV-----------KGVS 708
Query: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP------DEFLQIKSLVLDGP 506
P+ ++ + + + + + G G ++ GG DE + I + +GP
Sbjct: 709 FDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGP 768
Query: 507 AALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPN 566
AA G + GD ++ VN + G H + V+ + G +V + + R + +P++
Sbjct: 769 AARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGA--GTAVQMRVWRERMV--EPEN-- 821
Query: 567 TSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPN 626
+V I P + S + G + P SP +
Sbjct: 822 -----AVTITPLRP---------EDDYSPRERRGGGLRLPLLPPESPGPLRQRH------ 861
Query: 627 DTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQR-------VKQIVD---SPR 676
+ + G GF+IA G R V +I + + R
Sbjct: 862 ----------------VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHR 905
Query: 677 CRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
L+ GD ++ +N +V H+ V +L + L + GG P P S P
Sbjct: 906 AGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPP 965
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLP-EFPPAEAQAPDQTDSSG-------QKK 788
+ S + L + +PS L +P E + P G
Sbjct: 966 TAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHS 1025
Query: 789 PDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGEC---------------- 832
PF + + + P + SGL G+R +N + +
Sbjct: 1026 SHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLEL 1085
Query: 833 -------PIPDYQEQDIFLWRKETGFGFRILGG-----NEPGEP----IYIGHIVPLGAA 876
P P + G I GG P +P I+I + P GAA
Sbjct: 1086 SLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
Query: 877 DTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
DGRLR G L+ V+ ++G +H VQL++
Sbjct: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 38.9 bits (89), Expect = 0.032
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
D DE + I + G A DG++ G ++ VN +LG TH + V++ +S +G ++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS--VGDTLT 1185
Query: 550 LELCRGYPLPFD 561
+ +C G+ D
Sbjct: 1186 VLVCDGFEASTD 1197
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 83.2 bits (204), Expect = 1e-15
Identities = 58/204 (28%), Positives = 89/204 (43%), Gaps = 18/204 (8%)
Query: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESS 1096
I R+ E PA R G ++VGD++L VNG ++ H + V ++ AG V +R+
Sbjct: 760 ISRVSEEGPAARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVW------ 812
Query: 1097 NATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELER 1156
+ E TIT +E R E P + + L R
Sbjct: 813 -RERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQR----HVACLAR 867
Query: 1157 GAKGFGFSLRGG------REYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMK 1210
+G GFS+ GG R + ++V R+AE G A R G +++GD +L ING +
Sbjct: 868 SERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEAR 927
Query: 1211 HSRAIELIKNGGRRVRLFLKRGDG 1234
H A+ L+ + L L+R G
Sbjct: 928 HDHAVSLLTAASPTIALLLEREAG 951
Score = 80.9 bits (198), Expect = 7e-15
Identities = 98/420 (23%), Positives = 161/420 (38%), Gaps = 79/420 (18%)
Query: 838 QEQDIFLWRKETGFGFRILGGNEP------GEPIYIGHIVPLGAADTDGRLRSGDELICV 891
+E + + R+ G G I GG E I+I + G A G +R GD+L+ V
Sbjct: 725 EELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAG-VRVGDKLLEV 783
Query: 892 DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKV-----VFAVPKTENEVPSPASSHHSS 946
+G + G H V+ ++ A + + R V V P + SP
Sbjct: 784 NGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGG 843
Query: 947 NQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGEN 1006
+ L E P ++ V+ + S G+G GG G PY R G+
Sbjct: 844 LRLPLLPPESPGPLRQRH----VACLARSERGLGFSIAGGKGST-----PY----RAGDA 890
Query: 1007 EGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSI 1066
F + RI EG A R G L+VGDR+L++NG +
Sbjct: 891 GIF---------------------------VSRIAEGGAAHRAGTLQVGDRVLSINGVDV 923
Query: 1067 TNKSHSDIVNLIKEAGNTVTLRI-------IPGDESSNATLLTNAEKIATITTTHTPSQQ 1119
T H V+L+ A T+ L + +P +++ T A +ITT TP
Sbjct: 924 TEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTA-TPGVP 982
Query: 1120 GTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNM------ 1173
G + + P +E + L R G S+ GG +++
Sbjct: 983 GLPSLAPSLLAA-----ALEGPYPVEE-----IRLPRAGGPLGLSIVGGSDHSSHPFGVQ 1032
Query: 1174 --DLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
+++ ++ G A R G +R+GD IL +NG+ ++ H A+ + + L ++R
Sbjct: 1033 EPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRR 1091
Score = 72.8 bits (177), Expect = 2e-12
Identities = 131/594 (22%), Positives = 226/594 (38%), Gaps = 105/594 (17%)
Query: 681 KEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSE----VTLLVQRGGLPVPKKSPKSQPL 736
KEG + V+ +V+ ++ +Q ++L+E + E +T+L Q GGL + K
Sbjct: 694 KEGAV---VSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTP 750
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDS----SGQKKPDPF 792
+ D + VS A ++L E Q + ++ G
Sbjct: 751 YKGDDEGIFISRVSEEGPAARAGVRVGDKLL-EVNGVALQGAEHHEAVEALRGAGTAVQM 809
Query: 793 KIWAQSRSMYENR----PMSPSPASGLSKGEREREINSTNFG----ECPIPDYQEQDIFL 844
++W + EN P+ P RER E P P Q L
Sbjct: 810 RVWRERMVEPENAVTITPLRPED----DYSPRERRGGGLRLPLLPPESPGPLRQRHVACL 865
Query: 845 WRKETGFGFRILGGN-----EPGEP-IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIG 898
R E G GF I GG G+ I++ I GAA G L+ GD ++ ++G V
Sbjct: 866 ARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTE 925
Query: 899 KSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRT 958
H V L+ A+ + L + R+ +P PSP HSS A++
Sbjct: 926 ARHDHAVSLLTAASPT--IALLLEREAGGPLP------PSPLP--HSSPPTAAV------ 969
Query: 959 PQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEG--FGFVIVSS 1016
+ S+ T + G + S + + + PY VE R G G IV
Sbjct: 970 ---ATTSITTATPGVPGLPSLAP-----SLLAAALEGPYPVEEIRLPRAGGPLGLSIVG- 1020
Query: 1017 VSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIV 1075
+ FG V P I +++ A R G L+VGDRILAVNG + + +H + V
Sbjct: 1021 -GSDHSSHPFG---VQEPGVFISKVLPRGLAARSG-LRVGDRILAVNGQDVRDATHQEAV 1075
Query: 1076 NLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQ 1135
+ + ++L + P+ G +E P +
Sbjct: 1076 SALLRPCLELSLLV-----------------------RRDPAPPGLRELCIQKAPGER-- 1110
Query: 1136 FEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIG 1195
+ + GA+G + R + +++ +++ G A R G++R+G
Sbjct: 1111 --------------LGISIRGGARGHAGNPRDPTDEG--IFISKVSPTGAAGRDGRLRVG 1154
Query: 1196 DEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG-DGSVPEYAMIPPNIAA 1248
+LE+N ++ + H A++L+++ G + + + G + S + P + A
Sbjct: 1155 LRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIA 1208
Score = 63.9 bits (154), Expect = 9e-10
Identities = 109/573 (19%), Positives = 205/573 (35%), Gaps = 110/573 (19%)
Query: 393 EAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAREVP 452
E + +++ Q+++++++++ + ++++ TEE ++ + + P + + V
Sbjct: 660 EEEEEEEGSPQEEEEEEEEENRAEEEEASTEEEDKEGAVVSAPSV-----------KGVS 708
Query: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEP------DEFLQIKSLVLDGP 506
P+ ++ + + + + + G G ++ GG DE + I + +GP
Sbjct: 709 FDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGP 768
Query: 507 AALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPN 566
AA G + GD ++ VN + G H + V+ + G +V + + R + +P++
Sbjct: 769 AARAG-VRVGDKLLEVNGVALQGAEHHEAVEALRGA--GTAVQMRVWRERMV--EPEN-- 821
Query: 567 TSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPN 626
+V I P + S + G + P SP +
Sbjct: 822 -----AVTITPLRP---------EDDYSPRERRGGGLRLPLLPPESPGPLRQRH------ 861
Query: 627 DTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQR-------VKQIVD---SPR 676
+ + G GF+IA G R V +I + + R
Sbjct: 862 ----------------VACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHR 905
Query: 677 CRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPL 736
L+ GD ++ +N +V H+ V +L + L + GG P P S P
Sbjct: 906 AGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPP 965
Query: 737 ERKDSQNSSQHSVSSHRSLHTASPSHSTQVLP-EFPPAEAQAPDQTDSSG-------QKK 788
+ S + L + +PS L +P E + P G
Sbjct: 966 TAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHS 1025
Query: 789 PDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGEC---------------- 832
PF + + + P + SGL G+R +N + +
Sbjct: 1026 SHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLEL 1085
Query: 833 -------PIPDYQEQDIFLWRKETGFGFRILGG-----NEPGEP----IYIGHIVPLGAA 876
P P + G I GG P +P I+I + P GAA
Sbjct: 1086 SLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAA 1145
Query: 877 DTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
DGRLR G L+ V+ ++G +H VQL++
Sbjct: 1146 GRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLR 1178
Score = 38.9 bits (89), Expect = 0.032
Identities = 21/72 (29%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 490 DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVD 549
D DE + I + G A DG++ G ++ VN +LG TH + V++ +S +G ++
Sbjct: 1128 DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRS--VGDTLT 1185
Query: 550 LELCRGYPLPFD 561
+ +C G+ D
Sbjct: 1186 VLVCDGFEASTD 1197
>gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens]
Length = 817
Score = 79.7 bits (195), Expect = 2e-14
Identities = 59/210 (28%), Positives = 101/210 (48%), Gaps = 24/210 (11%)
Query: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRI------- 1089
I +IIEG A + G+L++GDR+LAVN ++ + H + V +K + V L++
Sbjct: 257 ITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLH 316
Query: 1090 -----IPGDESSNATLLTNAEKIATITTTHTPSQQGTQETR-NTTKPKQESQFEFK-APQ 1142
P D +S T L + I+ + G E++ + P Q + P+
Sbjct: 317 LNDMYAPPDYASTFTALADNH----ISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPR 372
Query: 1143 ATQEQDFYTVE-----LERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDE 1197
++ +T E L +G+ G GF++ GG E ++V + GPA+ G++R GD
Sbjct: 373 HMLAEEDFTREPRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDR 431
Query: 1198 ILEINGETTKNMKHSRAIELIKNGGRRVRL 1227
IL +NG +N H +A +K G+ V +
Sbjct: 432 ILSVNGVNLRNATHEQAAAALKRAGQSVTI 461
Score = 69.3 bits (168), Expect = 2e-11
Identities = 66/263 (25%), Positives = 109/263 (41%), Gaps = 43/263 (16%)
Query: 841 DIFLWRKETGFGFRILGG----NEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTP 895
++ L + G GF I GG + PG+ IYI I+ GAA DGRL+ GD L+ V+ T
Sbjct: 226 EVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTN 285
Query: 896 VIGKSHQLVVQLMQQAAKQGHVNL----TVRRKVVFAVPKTENEVPSPASSHHSSNQP-- 949
+ H+ V ++ + ++ + ++ ++A P + + A +H S N
Sbjct: 286 LQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHISHNSSLG 345
Query: 950 -----ASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRG 1004
S PQ + + + +P + + +G
Sbjct: 346 YLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDF-------------TREPRKIILHKG 392
Query: 1005 ENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGC 1064
+ G GF IV +F I+ G PAD G+L+ GDRIL+VNG
Sbjct: 393 -STGLGFNIVGGEDGEGIFVSF-------------ILAGGPADLSGELRRGDRILSVNGV 438
Query: 1065 SITNKSHSDIVNLIKEAGNTVTL 1087
++ N +H +K AG +VT+
Sbjct: 439 NLRNATHEQAAAALKRAGQSVTI 461
Score = 68.2 bits (165), Expect = 5e-11
Identities = 62/256 (24%), Positives = 99/256 (38%), Gaps = 63/256 (24%)
Query: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
++ + RG N G GF I + P G I +II G A G+L V D
Sbjct: 131 EIVLERG-NSGLGFSIAGGIDNPHVPDDPGIF-------ITKIIPGGAAAMDGRLGVNDC 182
Query: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
+L VN ++ HS V +KEAG V L +
Sbjct: 183 VLRVNEVDVSEVVHSRAVEALKEAGPVVRLVV---------------------------- 214
Query: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREY-----N 1172
+P E+ E V L +G KG GFS+ GG +
Sbjct: 215 --------RRRQPPPETIME--------------VNLLKGPKGLGFSIAGGIGNQHIPGD 252
Query: 1173 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRG 1232
+Y+ ++ E G A++ G+++IGD +L +N ++++H A+ +KN V L + +
Sbjct: 253 NSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312
Query: 1233 DGSVPEYAMIPPNIAA 1248
PP+ A+
Sbjct: 313 GSLHLNDMYAPPDYAS 328
Score = 60.8 bits (146), Expect = 8e-09
Identities = 67/283 (23%), Positives = 113/283 (39%), Gaps = 59/283 (20%)
Query: 641 LITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVNK 691
++ V+++KGP G GF+IA PG + +I++ + L+ GD ++ VN
Sbjct: 224 IMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNN 283
Query: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSS 751
N+Q + H + V L V L V + G S + S+ +++
Sbjct: 284 TNLQDVRHEEAVASLKNT--SDMVYLKVAKPG------SLHLNDMYAPPDYASTFTALAD 335
Query: 752 HRSLHTASPSHSTQVLPEFP-PAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPS 810
+ H +S + V + PA Q P SP
Sbjct: 336 NHISHNSSLGYLGAVESKVSYPAPPQVPPTR-------------------------YSPI 370
Query: 811 PASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHI 870
P L++ + RE + I L + TG GF I+GG E GE I++ I
Sbjct: 371 PRHMLAEEDFTRE---------------PRKIILHKGSTGLGFNIVGG-EDGEGIFVSFI 414
Query: 871 VPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
+ G AD G LR GD ++ V+G + +H+ +++A +
Sbjct: 415 LAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQ 457
Score = 59.7 bits (143), Expect = 2e-08
Identities = 79/303 (26%), Positives = 121/303 (39%), Gaps = 43/303 (14%)
Query: 471 IHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
+ L K +G GF++ GG D + I ++ G A DG+++ GD +++VN+T
Sbjct: 225 MEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNT 284
Query: 526 CVLGHTHAQVVKIFQS------IPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKE 579
+ H + V ++ + + L L Y P S T++A
Sbjct: 285 NLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPP-----DYASTFTALA----- 334
Query: 580 PIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIAT-Q 638
D+ SH+S G + G +++ S PA + P LA T +
Sbjct: 335 ----------DNHISHNSSLGYL-GAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTRE 383
Query: 639 PELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLKEGDLIVEVNKKNVQ 695
P I +H KG G GF I G G V I+ + L+ GD I+ VN N++
Sbjct: 384 PRKIILH--KGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLR 441
Query: 696 ALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSL 755
TH Q L G VT++ Q + K L R+ NSS S S SL
Sbjct: 442 NATHEQAAAALKRA--GQSVTIVAQYRPEEYSRFESKIHDL-REQMMNSSMSSGSG--SL 496
Query: 756 HTA 758
T+
Sbjct: 497 RTS 499
Score = 50.8 bits (120), Expect = 8e-06
Identities = 34/100 (34%), Positives = 49/100 (49%), Gaps = 9/100 (9%)
Query: 435 PVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDE 494
P P PP+ P L + F TR P ++ L K S G GF +VGG++ E
Sbjct: 357 PAPPQVPPTRYSPIPRHMLAEEDF-TREPRKII-------LHKGSTGLGFNIVGGED-GE 407
Query: 495 FLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQ 534
+ + ++ GPA L G++ GD I+SVN + TH Q
Sbjct: 408 GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 447
Score = 45.8 bits (107), Expect = 3e-04
Identities = 33/93 (35%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 837 YQEQDIFLWRKETGFGFRILGGNE----PGEP-IYIGHIVPLGAADTDGRLRSGDELICV 891
++ ++I L R +G GF I GG + P +P I+I I+P GAA DGRL D ++ V
Sbjct: 127 FKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRV 186
Query: 892 DGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 924
+ V H V+ +++A V L VRR+
Sbjct: 187 NEVDVSEVVHSRAVEALKEAGPV--VRLVVRRR 217
Score = 42.0 bits (97), Expect = 0.004
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 462 NPSELKGKFIHTKLRKSSRGFGFTVVGG-DEP----DEFLQIKSLVLDGPAALDGKMETG 516
N S+ K+ L + + G GF++ GG D P D + I ++ G AA+DG++
Sbjct: 121 NGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVN 180
Query: 517 DVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLP 559
D ++ VN+ V H++ V+ + G V L + R P P
Sbjct: 181 DCVLRVNEVDVSEVVHSRAVEALKE--AGPVVRLVVRRRQPPP 221
Score = 41.2 bits (95), Expect = 0.006
Identities = 20/49 (40%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR R+ EV G DY+F+ +E ++ + Q +E G + N YGT
Sbjct: 656 VPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGT 704
>gi|24025688 ligand of numb-protein X 2 [Homo sapiens]
Length = 690
Score = 79.3 bits (194), Expect = 2e-14
Identities = 64/234 (27%), Positives = 106/234 (45%), Gaps = 39/234 (16%)
Query: 858 GNEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGH 916
G++ GE PI++ + P G DGR++ GD L+ ++G + SH V +++ +A
Sbjct: 488 GSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLKASAASPA 547
Query: 917 VNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGST 976
V A+ E ++ A+ + + QP++ +E + S + + +
Sbjct: 548 V----------ALKALEVQIVEEATQN-AEEQPSTFSENEYDASWSPSWVMWL------- 589
Query: 977 SGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHK 1036
G+ ST+ +D+ +RR +GF IV P
Sbjct: 590 -----------GLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENHTN---------QPFF 629
Query: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII 1090
I I+ G+PA G+LK GD I+AVNG S SHS +V ++KE N VTL +I
Sbjct: 630 IKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
Score = 77.4 bits (189), Expect = 8e-14
Identities = 92/426 (21%), Positives = 173/426 (40%), Gaps = 61/426 (14%)
Query: 820 REREINST--NFGECPIPDYQEQDIFLWRKETG--FGFRILGG-NEPGEPIYIGHIVPLG 874
RER + N + P + + L ++++G G +++ +EPG ++I ++ G
Sbjct: 316 RERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPG--VFILDLLEGG 373
Query: 875 AADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTEN 934
A DGRL S D ++ ++G + + +L Q++Q + ++ VNLT+ R P+ N
Sbjct: 374 LAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGER--VNLTIARP---GKPQPGN 428
Query: 935 EVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVV 994
+ A +H SS+Q + P ++ V+
Sbjct: 429 TIRE-AGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTC----------------------- 464
Query: 995 QPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKV 1054
Q + +++ +E G + G+ +P + + R G++K
Sbjct: 465 QEKHITVKKEPHESLGMTVAGGR---------GSKSGELPIFVTSVPPHGCLARDGRIKR 515
Query: 1055 GDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTH 1114
GD +L +NG +TN SHS+ V ++K + +S A L E T
Sbjct: 516 GDVLLNINGIDLTNLSHSEAVAMLKASA------------ASPAVALKALEVQIVEEATQ 563
Query: 1115 TPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKG-FGFSLRGGREYN- 1172
+Q + + N + + + + L R G +GFS+ GG E N
Sbjct: 564 NAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHDIVLRRSYLGSWGFSIVGGYEENH 623
Query: 1173 --MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLK 1230
++ + PA G+++ GD I+ +NG +T M HS + ++K +V L +
Sbjct: 624 TNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGMSHSALVPMLKEQRNKVTLTVI 683
Query: 1231 RGDGSV 1236
GS+
Sbjct: 684 CWPGSL 689
Score = 57.8 bits (138), Expect = 7e-08
Identities = 49/204 (24%), Positives = 91/204 (44%), Gaps = 14/204 (6%)
Query: 1040 IIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
++EG A + G+L DR+LA+NG + + +I+ +G V L I +
Sbjct: 369 LLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQPGN 428
Query: 1100 LLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAK 1159
+ A ++ + HTP ++ + + K +Q T ++ TV+ E +
Sbjct: 429 TIREAGNHSSSSQHHTPPPYYSRPSSH----KDLTQC------VTCQEKHITVKKEPH-E 477
Query: 1160 GFGFSLRGGR---EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIE 1216
G ++ GGR + ++V + G R G+++ GD +L ING N+ HS A+
Sbjct: 478 SLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVA 537
Query: 1217 LIKNGGRRVRLFLKRGDGSVPEYA 1240
++K + LK + + E A
Sbjct: 538 MLKASAASPAVALKALEVQIVEEA 561
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/70 (40%), Positives = 46/70 (65%), Gaps = 4/70 (5%)
Query: 475 LRKSSRG-FGFTVVGGDEPDEFLQ---IKSLVLDGPAALDGKMETGDVIVSVNDTCVLGH 530
LR+S G +GF++VGG E + Q IK++VL PA DG+++ GD+IV+VN +G
Sbjct: 603 LRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTVGM 662
Query: 531 THAQVVKIFQ 540
+H+ +V + +
Sbjct: 663 SHSALVPMLK 672
Score = 47.0 bits (110), Expect = 1e-04
Identities = 44/186 (23%), Positives = 72/186 (38%), Gaps = 40/186 (21%)
Query: 1048 RCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKI 1107
R G+L GD+IL VN +I+N SH+ ++ + NT+ L ++ +
Sbjct: 273 RDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLHLTVL------------RERRF 320
Query: 1108 ATITTTHTPSQQGTQETRNTTKPKQES--QFEFKAPQATQEQDFYTVELERGAKGFGFSL 1165
H+ S +E K++S Q K + T E
Sbjct: 321 GNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEP------------------ 362
Query: 1166 RGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRV 1225
+++L L E G A + G++ D +L ING K A ++I+ G RV
Sbjct: 363 --------GVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERV 414
Query: 1226 RLFLKR 1231
L + R
Sbjct: 415 NLTIAR 420
Score = 40.8 bits (94), Expect = 0.008
Identities = 60/261 (22%), Positives = 95/261 (36%), Gaps = 27/261 (10%)
Query: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSS 751
K L H + +LV CP S ++QR L K+ R + + ++
Sbjct: 97 KKSSILVHKLLDKLLVLCPFSSVCKDVMQRCDLEAHLKN-------RCPGASHRRVALER 149
Query: 752 HRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSP 811
++ T + + PA +P+ P + + S S + P +P
Sbjct: 150 RKTSRTQAEIENENGPTLLDPAGTLSPEADCLGTGAVPVERHLTSASLSTWSEEPGLDNP 209
Query: 812 ASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKET--GFGFRILGGNE-PGEPIYIG 868
A S G T +P+ + I + R G I+GGNE P I I
Sbjct: 210 AFEESAGA------DTTQQPLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQ 263
Query: 869 HIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFA 928
+ G DGRL +GD+++ V+ + SH ++ Q H LTV R
Sbjct: 264 EVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQPCNTLH--LTVLR----- 316
Query: 929 VPKTENEVPSPASSHHSSNQP 949
E + A +H SN P
Sbjct: 317 ----ERRFGNRAHNHSDSNSP 333
Score = 38.5 bits (88), Expect = 0.042
Identities = 22/77 (28%), Positives = 39/77 (50%), Gaps = 3/77 (3%)
Query: 1141 PQATQEQDFYTVELERGAK--GFGFSLRGGREYNM-DLYVLRLAEDGPAERCGKMRIGDE 1197
P + E + T+E+ R G S+ GG E + ++ + + DG R G++ GD+
Sbjct: 223 PLSLPEGEITTIEIHRSNPYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQ 282
Query: 1198 ILEINGETTKNMKHSRA 1214
IL++N N+ H+ A
Sbjct: 283 ILQVNNYNISNVSHNYA 299
Score = 35.4 bits (80), Expect = 0.35
Identities = 27/96 (28%), Positives = 47/96 (48%), Gaps = 10/96 (10%)
Query: 12 TSRVHECTVKRGPQGELGVTVLG--GAEHGEFP-YVGAVAAVEAAGLPGGGEGPRLGEGE 68
T + TVK+ P LG+TV G G++ GE P +V +V G R+ G+
Sbjct: 463 TCQEKHITVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDG-----RIKRGD 517
Query: 69 LLLEVQGVRVSGLPRYDVLGVI--DSCKEAVTFKAV 102
+LL + G+ ++ L + + ++ + AV KA+
Sbjct: 518 VLLNINGIDLTNLSHSEAVAMLKASAASPAVALKAL 553
Score = 35.0 bits (79), Expect = 0.46
Identities = 67/294 (22%), Positives = 111/294 (37%), Gaps = 70/294 (23%)
Query: 483 GFTVVGGDE-PDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCV--LGHTHAQVV--- 536
G ++VGG+E P + I+ + DG A DG++ GD I+ VN+ + + H +A+ V
Sbjct: 246 GISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYARAVLSQ 305
Query: 537 ------------------------------KIFQ----SIPIGASVDLELCRGYPLP--F 560
+IFQ G + ++L R P F
Sbjct: 306 PCNTLHLTVLRERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTDEPGVF 365
Query: 561 DPDDPNTSLVTSVAILDKEP--IIVNGQE-TYDSP---ASHSSKTGKVNGMKDARPSSP- 613
D L L + +NG + Y +P A +G+ + ARP P
Sbjct: 366 ILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIARPGKPQ 425
Query: 614 --------ADVASNSSHGYPNDTVSLASSIATQPELIT-----VHIVKGP-MGFGFTIAD 659
+ +S+S H P S SS + +T + + K P G T+A
Sbjct: 426 PGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLGMTVAG 485
Query: 660 SPGGGGQRVKQIVDSPRCRG-------LKEGDLIVEVNKKNVQALTHNQVVDML 706
G + V S G +K GD+++ +N ++ L+H++ V ML
Sbjct: 486 GRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAML 539
Score = 31.2 bits (69), Expect = 6.7
Identities = 20/82 (24%), Positives = 42/82 (51%), Gaps = 3/82 (3%)
Query: 473 TKLRKSSRGFGFTVVGG--DEPDEF-LQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLG 529
T ++ G TV GG + E + + S+ G A DG+++ GDV++++N +
Sbjct: 470 TVKKEPHESLGMTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTN 529
Query: 530 HTHAQVVKIFQSIPIGASVDLE 551
+H++ V + ++ +V L+
Sbjct: 530 LSHSEAVAMLKASAASPAVALK 551
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 78.6 bits (192), Expect = 4e-14
Identities = 60/240 (25%), Positives = 111/240 (46%), Gaps = 29/240 (12%)
Query: 990 VSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRC 1049
+++ P + ++ + E + +GF + R E T H + + + SPA++
Sbjct: 1 MTSTFNPRECKLSKQEGQNYGFFL-----RIEKDTE--------GHLVRVVEKCSPAEKA 47
Query: 1050 GKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIAT 1109
G L+ GDR+L +NG + + H +V+L++++GN+VTL ++ GD A ++
Sbjct: 48 G-LQDGDRVLRINGVFVDKEEHMQVVDLVRKSGNSVTLLVLDGDSYEKAV----KTRVDL 102
Query: 1110 ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGR 1169
+ +QG + N P + TQ + Y V+ E G+ GF G+
Sbjct: 103 KELGQSQKEQGLSD--NILSPVMNGGVQ----TWTQPRLCYLVK-EGGSYGFSLKTVQGK 155
Query: 1170 EYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFL 1229
+ +Y+ + G A R G + D ++E+NGE ++ H +E +K G RV L
Sbjct: 156 K---GVYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLL 211
Score = 70.5 bits (171), Expect = 1e-11
Identities = 90/386 (23%), Positives = 154/386 (39%), Gaps = 83/386 (21%)
Query: 850 GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQ 909
GF + + G + +Y+ I P G A G L + D LI V+G V SH+ VV+ ++
Sbjct: 146 GFSLKTVQGKKG---VYMTDITPQGVAMRAGVL-ADDHLIEVNGENVEDASHEEVVEKVK 201
Query: 910 QAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTV 969
++ +V+F + E + + ASL K P
Sbjct: 202 KSGS----------RVMFLLVDKETDKRHVEQKIQFKRETASL---KLLPH--------- 239
Query: 970 SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNA 1029
QP VE+++G N G+GF + AG+
Sbjct: 240 -------------------------QPRIVEMKKGSN-GYGFYL-------RAGS----- 261
Query: 1030 CVAMPHKIGRIIE----GSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV 1085
+ G+II+ GSPA+ G LK D ++AVNG S+ H +V +I++ G+
Sbjct: 262 -----EQKGQIIKDIDSGSPAEEAG-LKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQT 315
Query: 1086 TLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQ 1145
+L ++ E+ N L + + P+ + P S P T+
Sbjct: 316 SLLVVD-KETDNMYRLAHFSPFLYYQSQELPNGS----VKEAPAPTPTSLEVSSPPDTTE 370
Query: 1146 EQDFYT--VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEING 1203
E D L +G G+GF L R ++ + + GPA+ G + D I+E+NG
Sbjct: 371 EVDHKPKLCRLAKGENGYGFHLNAIRGLPGS-FIKEVQKGGPADLAG-LEDEDVIIEVNG 428
Query: 1204 ETTKNMKHSRAIELIKNGGRRVRLFL 1229
+ + + ++ I++ G+ V L +
Sbjct: 429 VNVLDEPYEKVVDRIQSSGKNVTLLV 454
Score = 53.5 bits (127), Expect = 1e-06
Identities = 71/300 (23%), Positives = 119/300 (39%), Gaps = 47/300 (15%)
Query: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
+++K S G+GF + G E QI + G A + ++ D++V+VN V H
Sbjct: 245 EMKKGSNGYGFYLRAGSEQKG--QIIKDIDSGSPAEEAGLKNNDLVVAVNGESVETLDHD 302
Query: 534 QVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPA 593
VV++ + G TS+ ++DKE + +
Sbjct: 303 SVVEMIRK---GGD----------------------QTSLLVVDKETDNMYRLAHFSPFL 337
Query: 594 SHSSKTGKVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGF 653
+ S+ +K+A +P + +S P DT + +P+L + KG G+
Sbjct: 338 YYQSQELPNGSVKEAPAPTPTSLEVSS----PPDT---TEEVDHKPKL--CRLAKGENGY 388
Query: 654 GFTIADSPGGGGQRVKQIVDS--PRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
GF + G G +K++ GL++ D+I+EVN NV + +VVD +
Sbjct: 389 GFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQS--S 446
Query: 712 GSEVTLLV-------QRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHST 764
G VTLLV +P S + PL+ S+H S +HST
Sbjct: 447 GKNVTLLVCGKKAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHST 506
Score = 51.2 bits (121), Expect = 6e-06
Identities = 100/417 (23%), Positives = 154/417 (36%), Gaps = 100/417 (23%)
Query: 575 ILDKEPIIVNGQETYDSPASHSSKTGKVNGMKDARPSSPADVASNSSH-----GYPNDTV 629
+ D I VNG+ D ASH KV D ++ H + +T
Sbjct: 175 LADDHLIEVNGENVED--ASHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETA 232
Query: 630 SLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCR--GLKEGDLIV 687
SL + QP + V + KG G+GF + GQ +K I GLK DL+V
Sbjct: 233 SL-KLLPHQPRI--VEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVV 289
Query: 688 EVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQH 747
VN ++V+ L H+ VV+M+ KG + T L L V K++
Sbjct: 290 AVNGESVETLDHDSVVEMI---RKGGDQTSL-----LVVDKETD---------------- 325
Query: 748 SVSSHRSLHTASP--SHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENR 805
+ +R H SP + +Q LP EA AP T PD + +++
Sbjct: 326 --NMYRLAH-FSPFLYYQSQELPNGSVKEAPAPTPTSLEVSSPPD-------TTEEVDHK 375
Query: 806 PMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILG-GNEPGEP 864
P A G E G+GF + PG
Sbjct: 376 PKLCRLAKG---------------------------------ENGYGFHLNAIRGLPGS- 401
Query: 865 IYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV--- 921
+I + G AD G L D +I V+G V+ + ++ VV +Q + K +V L V
Sbjct: 402 -FIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGK--NVTLLVCGK 457
Query: 922 ------RRKVVFAVPKTENEVPSPASSHH----SSNQPASLTEEKRTPQGSQNSLNT 968
+ K + V + + +P S SN + + +E+ S +S N+
Sbjct: 458 KAYDYFQAKKIPIVSSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNS 514
Score = 47.4 bits (111), Expect = 9e-05
Identities = 62/258 (24%), Positives = 111/258 (43%), Gaps = 47/258 (18%)
Query: 837 YQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPV 896
+Q + + + + G+GF + G+E I + G+ + L++ D ++ V+G V
Sbjct: 239 HQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKD--IDSGSPAEEAGLKNNDLVVAVNGESV 296
Query: 897 IGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVP----SPASSHHSSNQPASL 952
H VV+++++ Q +L V K +T+N SP + S P
Sbjct: 297 ETLDHDSVVEMIRKGGDQ--TSLLVVDK------ETDNMYRLAHFSPFLYYQSQELPNGS 348
Query: 953 TEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFV 1012
+E P + SL VSS +T + +P + +GEN G+GF
Sbjct: 349 VKEAPAP--TPTSLE-VSSPPDTTEEVDH-------------KPKLCRLAKGEN-GYGFH 391
Query: 1013 IVSSVSRPEAGTTFGNACVAMPHK-IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSH 1071
+ NA +P I + +G PAD G L+ D I+ VNG ++ ++ +
Sbjct: 392 L--------------NAIRGLPGSFIKEVQKGGPADLAG-LEDEDVIIEVNGVNVLDEPY 436
Query: 1072 SDIVNLIKEAGNTVTLRI 1089
+V+ I+ +G VTL +
Sbjct: 437 EKVVDRIQSSGKNVTLLV 454
Score = 40.8 bits (94), Expect = 0.008
Identities = 24/76 (31%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 1159 KGFGFSLRGGREYNMDLYVLRLAED-GPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1217
+ +GF LR E + + +++R+ E PAE+ G ++ GD +L ING +H + ++L
Sbjct: 18 QNYGFFLR--IEKDTEGHLVRVVEKCSPAEKAG-LQDGDRVLRINGVFVDKEEHMQVVDL 74
Query: 1218 IKNGGRRVRLFLKRGD 1233
++ G V L + GD
Sbjct: 75 VRKSGNSVTLLVLDGD 90
Score = 33.5 bits (75), Expect = 1.3
Identities = 24/71 (33%), Positives = 34/71 (47%), Gaps = 2/71 (2%)
Query: 652 GFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPK 711
GF I G RV + GL++GD ++ +N V H QVVD++ +
Sbjct: 21 GFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKEEHMQVVDLVRK--S 78
Query: 712 GSEVTLLVQRG 722
G+ VTLLV G
Sbjct: 79 GNSVTLLVLDG 89
Score = 33.1 bits (74), Expect = 1.8
Identities = 26/87 (29%), Positives = 46/87 (52%), Gaps = 10/87 (11%)
Query: 637 TQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEG----DLIVEVNKK 692
TQP L ++VK +GF++ G G + I +P+ ++ G D ++EVN +
Sbjct: 131 TQPRLC--YLVKEGGSYGFSLKTVQGKKGVYMTDI--TPQGVAMRAGVLADDHLIEVNGE 186
Query: 693 NVQALTHNQVVDMLVECPKGSEVTLLV 719
NV+ +H +VV+ + + GS V L+
Sbjct: 187 NVEDASHEEVVEKVKK--SGSRVMFLL 211
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 77.0 bits (188), Expect = 1e-13
Identities = 119/484 (24%), Positives = 197/484 (40%), Gaps = 66/484 (13%)
Query: 480 RGFGFTVVGG-DEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKI 538
RGFG + GG D P + + +V GPA +G+++TGD IV VN + T A ++I
Sbjct: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPA--EGRLQTGDHIVMVNGVSMENATSAFAIQI 96
Query: 539 FQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSK 598
++ A++ ++ R LP P++ D + + SS
Sbjct: 97 LKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSG 156
Query: 599 TGKVNGMKDARPSSPADVASNSSHGYPN-------DTVSLASSIATQPEL-ITVHIVKGP 650
+G+ + RP P SHG + + ++L S P + + VK
Sbjct: 157 SGRSWDERSRRPR-PGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSV 215
Query: 651 M-------GFGFTIADSPGGGGQRVKQIVDS---PRCRGLKEGDLIVEVNKKNVQALTHN 700
+ FG + G +K I DS R RGL+EGDLI+++N + Q L+ N
Sbjct: 216 LVKRRDSEEFGVKL-----GSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLN 270
Query: 701 QVVDMLVECPKGSEVTLLVQRG------GLPVPKKSPKSQPLER----KDSQNSSQHSVS 750
L+E +G +++LLV R +P S PLE D +S +S
Sbjct: 271 D-TRRLIEKSEG-KLSLLVLRDRGQFLVNIPPAVSDSDSSPLEEGVTMADEMSSPPADIS 328
Query: 751 SHRS-LHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSP 809
S L A PSH +P PP AQ + + P + S ++R +S
Sbjct: 329 DLASELSQAPPSH----IPP-PPRHAQRSPEASQTDSPVESP---RLRRESSVDSRTIS- 379
Query: 810 SPASGLSKGEREREINSTNFGECPIPDYQEQD---------IFLWRKETGFGFRILGGNE 860
P S+ RE +++ +P Q + + + K G R+ GGN+
Sbjct: 380 EPDEQRSELPRE-----SSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGND 434
Query: 861 PGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLT 920
G I++ + AD G ++ GD+++ V+ P + + VQ + + L
Sbjct: 435 VG--IFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELV 491
Query: 921 VRRK 924
+RK
Sbjct: 492 TQRK 495
Score = 72.4 bits (176), Expect = 3e-12
Identities = 103/476 (21%), Positives = 181/476 (38%), Gaps = 114/476 (23%)
Query: 840 QDIFLWRKET---------GFGFRILGGNE-PGEPIYIGHIVPLGAADTDGRLRSGDELI 889
+++ +W + T GFG I GG + PG + + +VP G A+ GRL++GD ++
Sbjct: 21 EELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIV 78
Query: 890 CVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQP 949
V+G + + +Q+++ K N+TV+R +P T+ SP +
Sbjct: 79 MVNGVSMENATSAFAIQILKTCTKM--ANITVKRPRRIHLPATKASPSSPGRQDSDEDDG 136
Query: 950 ASLTEEKRTPQGSQNSLNTVSS---------------GSGSTSGIGSGGGGGSGVVSTVV 994
EE +G ++ S G + G S GGG +V
Sbjct: 137 PQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALV 196
Query: 995 QPY------DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADR 1048
+ DV+++ ++ V+V E G G+ I I + A R
Sbjct: 197 SGFKRLPRQDVQMKPVKS-----VLVKRRDSEEFGVKLGSQIF-----IKHITDSGLAAR 246
Query: 1049 CGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII------------------ 1090
L+ GD IL +NG S N S +D LI+++ ++L ++
Sbjct: 247 HRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSD 306
Query: 1091 ---------PGDESSN--ATLLTNAEKIATITTTHTP----SQQGTQETRNTTKP----- 1130
DE S+ A + A +++ +H P Q + E T P
Sbjct: 307 SSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPR 366
Query: 1131 -KQESQFEFKAPQATQEQ----------DFYTVEL-----ERG------------AKGFG 1162
++ES + + EQ D Y V +RG K G
Sbjct: 367 LRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIG 426
Query: 1163 FSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1218
L GG + + ++V + PA+ G ++ GD+IL++N +N+ A++ +
Sbjct: 427 LRLAGGND--VGIFVSGVQAGSPADGQG-IQEGDQILQVNDVPFQNLTREEAVQFL 479
Score = 45.8 bits (107), Expect = 3e-04
Identities = 116/514 (22%), Positives = 194/514 (37%), Gaps = 108/514 (21%)
Query: 643 TVHIVKGPM-GFGFTIA---DSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALT 698
T + K P GFG I+ D PGG + P L+ GD IV VN +++ T
Sbjct: 30 TATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENAT 89
Query: 699 HNQVVDMLVECPKGSEVTL-LVQRGGLPVPKKSPKSQPLERKDSQNSSQ--HSVSSHRSL 755
+ +L C K + +T+ +R LP K SP S + D + Q V R
Sbjct: 90 SAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGY 149
Query: 756 HTASPSHSTQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGL 815
S S S + E ++P P + ++ S P S A+GL
Sbjct: 150 DGDSSSGSGRSWDE---------------RSRRPRPGR-RGRAGSHGRRSPGGGSEANGL 193
Query: 816 SKGEREREINSTNFGECPIPDYQ---EQDIFLWRKET-GFGFRILGGNEPGEPIYIGHIV 871
+ + F P D Q + + + R+++ FG ++ G I+I HI
Sbjct: 194 AL--------VSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKL------GSQIFIKHIT 239
Query: 872 PLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK----VVF 927
G A L+ GD ++ ++G S +L++++ +G ++L V R +V
Sbjct: 240 DSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKS--EGKLSLLVLRDRGQFLVN 297
Query: 928 AVPKTENEVPSP-----ASSHHSSNQPASLTE-------------------EKRTPQGSQ 963
P + SP + S+ PA +++ +R+P+ SQ
Sbjct: 298 IPPAVSDSDSSPLEEGVTMADEMSSPPADISDLASELSQAPPSHIPPPPRHAQRSPEASQ 357
Query: 964 NSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQP------------YDV-EIRRGEN-EGF 1009
S S + S T+ +P YD+ + ++ E
Sbjct: 358 TDSPVESPRLRRESSVDS---------RTISEPDEQRSELPRESSYDIYRVPSSQSMEDR 408
Query: 1010 GFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIE----GSPADRCGKLKVGDRILAVNGCS 1065
G+ + V R G + G +A + +G + GSPAD G ++ GD+IL VN
Sbjct: 409 GYSPDTRVVRFLKGKSIG-LRLAGGNDVGIFVSGVQAGSPADGQG-IQEGDQILQVNDVP 466
Query: 1066 ITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNAT 1099
N + + V + L + PG+E T
Sbjct: 467 FQNLTREEAVQFL--------LGLPPGEEMELVT 492
Score = 42.7 bits (99), Expect = 0.002
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 3/74 (4%)
Query: 1159 KGFGFSLRGGREY-NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIEL 1217
+GFG ++ GGR+ + V + GPAE G+++ GD I+ +NG + +N + AI++
Sbjct: 39 RGFGIAISGGRDRPGGSMVVSDVVPGGPAE--GRLQTGDHIVMVNGVSMENATSAFAIQI 96
Query: 1218 IKNGGRRVRLFLKR 1231
+K + + +KR
Sbjct: 97 LKTCTKMANITVKR 110
Score = 31.2 bits (69), Expect = 6.7
Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 10/144 (6%)
Query: 414 QQQQQQQQTEEWTEDHSALVPPVIPNHPPSNPEPAR-EVPLQGKPFFTRNPS----ELKG 468
Q+ + QT+ E + + S P+ R E+P + R PS E +G
Sbjct: 350 QRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRG 409
Query: 469 KFIHTKLRKSSRG--FGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTC 526
T++ + +G G + GG++ F+ S V G A ++ GD I+ VND
Sbjct: 410 YSPDTRVVRFLKGKSIGLRLAGGNDVGIFV---SGVQAGSPADGQGIQEGDQILQVNDVP 466
Query: 527 VLGHTHAQVVKIFQSIPIGASVDL 550
T + V+ +P G ++L
Sbjct: 467 FQNLTREEAVQFLLGLPPGEEMEL 490
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 76.3 bits (186), Expect = 2e-13
Identities = 69/266 (25%), Positives = 113/266 (42%), Gaps = 33/266 (12%)
Query: 841 DIFLWRKETGFGFRILGG----NEPGE-PIYIGHIVPLGAADTDGRLRSGDELICVDGTP 895
+I L++ G GF I GG + PG+ IY+ I+ GAA DGRL+ GD L+ V+
Sbjct: 142 EIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYS 201
Query: 896 VIGKSHQLVVQLMQQAAKQGHVNL----TVRRKVVFAVPKTENEVPSPASSHHSSNQPAS 951
+ +H+ V +++ ++ ++ + T+ + P + P +H S +
Sbjct: 202 LEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGT 261
Query: 952 LTEEKRTPQGSQNSLNTV----------SSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEI 1001
L + P S + + +S S ++ VS +P V +
Sbjct: 262 LEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVL 321
Query: 1002 RRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAV 1061
+G G GF IV +F I+ G PAD G+L+ GD+IL+V
Sbjct: 322 HKGST-GLGFNIVGGEDGEGIFVSF-------------ILAGGPADLSGELQRGDQILSV 367
Query: 1062 NGCSITNKSHSDIVNLIKEAGNTVTL 1087
NG + SH +K AG TVT+
Sbjct: 368 NGIDLRGASHEQAAAALKGAGQTVTI 393
Score = 75.9 bits (185), Expect = 2e-13
Identities = 68/277 (24%), Positives = 120/277 (43%), Gaps = 57/277 (20%)
Query: 989 VVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKI--GRIIEGSPA 1046
++ TVV+ +++ +G +G GF I V GN + + I +II+G A
Sbjct: 136 ILETVVE---IKLFKGP-KGLGFSIAGGV---------GNQHIPGDNSIYVTKIIDGGAA 182
Query: 1047 DRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEK 1106
+ G+L+VGDR+L VN S+ +H + V ++K V L++ +T+
Sbjct: 183 QKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV----GKPTTIYMTDPYG 238
Query: 1107 IATITTTHTPSQQ--------GTQETRNTTKPKQESQFEFKAPQATQEQDFYT------- 1151
IT +++P + GT E + + P ++ P+ D YT
Sbjct: 239 PPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYS-PIPKHMLVDDDYTSHSQHST 297
Query: 1152 ---------------------VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCG 1190
V L +G+ G GF++ GG E ++V + GPA+ G
Sbjct: 298 ATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSG 356
Query: 1191 KMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1227
+++ GD+IL +NG + H +A +K G+ V +
Sbjct: 357 ELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTI 393
Score = 73.9 bits (180), Expect = 9e-13
Identities = 61/235 (25%), Positives = 95/235 (40%), Gaps = 63/235 (26%)
Query: 998 DVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR 1057
++ + RG N G GF I P G G I +II G A G+L+V D
Sbjct: 47 EITLERG-NSGLGFSIAGGTDNPHIGDDPGIF-------ITKIIPGGAAAEDGRLRVNDC 98
Query: 1058 ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPS 1117
IL VN ++ SHS V +KEAG+ V L +
Sbjct: 99 ILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV---------------------------- 130
Query: 1118 QQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGG-----REYN 1172
+P E+ E K L +G KG GFS+ GG +
Sbjct: 131 --------RRRRPILETVVEIK--------------LFKGPKGLGFSIAGGVGNQHIPGD 168
Query: 1173 MDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRL 1227
+YV ++ + G A++ G++++GD +L +N + + + H A+ ++KN V L
Sbjct: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 223
Score = 69.3 bits (168), Expect = 2e-11
Identities = 71/287 (24%), Positives = 116/287 (40%), Gaps = 51/287 (17%)
Query: 641 LITVHIVKGPMGFGFTIADS------PGGGGQRVKQIVDSPRCRG---LKEGDLIVEVNK 691
++ + + KGP G GF+IA PG V +I+D + L+ GD ++ VN
Sbjct: 140 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNN 199
Query: 692 KNVQALTHNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSS 751
+++ +TH + V +L SEV L + P P HS S
Sbjct: 200 YSLEEVTHEEAVAILKNT---SEVVYLKVGKPTTIYMTDPYGPP--------DITHSYSP 248
Query: 752 HRSLHTASPSHST-QVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQ----SRSMYENRP 806
H S ++ T + PP S G+ P P + S S +
Sbjct: 249 PMENHLLSGNNGTLEYKTSLPPI---------SPGRYSPIPKHMLVDDDYTSHSQHSTAT 299
Query: 807 MSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIY 866
PS +R ++ + + + L + TG GF I+GG E GE I+
Sbjct: 300 RQPSMTL-------QRAVSLEG---------EPRKVVLHKGSTGLGFNIVGG-EDGEGIF 342
Query: 867 IGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAK 913
+ I+ G AD G L+ GD+++ V+G + G SH+ ++ A +
Sbjct: 343 VSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQ 389
Score = 62.8 bits (151), Expect = 2e-09
Identities = 34/107 (31%), Positives = 57/107 (53%), Gaps = 6/107 (5%)
Query: 1131 KQESQFEFKAPQATQ-EQDFYTVELERGAKGFGFSLRGGREY-----NMDLYVLRLAEDG 1184
+Q Q F T+ E +F + LERG G GFS+ GG + + +++ ++ G
Sbjct: 26 EQAMQHAFIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGG 85
Query: 1185 PAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKR 1231
A G++R+ D IL +N + HS+A+E +K G VRL+++R
Sbjct: 86 AAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 132
Score = 58.9 bits (141), Expect = 3e-08
Identities = 69/279 (24%), Positives = 111/279 (39%), Gaps = 52/279 (18%)
Query: 471 IHTKLRKSSRGFGFTVVGGD-----EPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDT 525
+ KL K +G GF++ GG D + + ++ G A DG+++ GD ++ VN+
Sbjct: 141 VEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNY 200
Query: 526 CVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNG 585
+ TH + V I ++ S + L G P DP P I +
Sbjct: 201 SLEEVTHEEAVAILKN----TSEVVYLKVGKPTTIYMTDPY-----------GPPDITH- 244
Query: 586 QETYDSPASHSSKTGKVNGMKDARPSSPA-----------------DVASNSSHG----Y 624
+Y P + +G NG + + S P D S+S H
Sbjct: 245 --SYSPPMENHLLSGN-NGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATRQ 301
Query: 625 PNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIV---DSPRCRGLK 681
P+ T+ A S+ +P + +H KG G GF I G G V I+ + L+
Sbjct: 302 PSMTLQRAVSLEGEPRKVVLH--KGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQ 359
Query: 682 EGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ 720
GD I+ VN +++ +H Q L G VT++ Q
Sbjct: 360 RGDQILSVNGIDLRGASHEQAAAALKGA--GQTVTIIAQ 396
Score = 51.6 bits (122), Expect = 5e-06
Identities = 36/96 (37%), Positives = 53/96 (55%), Gaps = 11/96 (11%)
Query: 836 DYQEQDIFLWRKETGFGFRILGG-------NEPGEPIYIGHIVPLGAADTDGRLRSGDEL 888
+Y+ ++I L R +G GF I GG ++PG I+I I+P GAA DGRLR D +
Sbjct: 42 EYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPG--IFITKIIPGGAAAEDGRLRVNDCI 99
Query: 889 ICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRK 924
+ V+ V SH V+ +++A V L VRR+
Sbjct: 100 LRVNEVDVSEVSHSKAVEALKEAG--SIVRLYVRRR 133
Score = 49.7 bits (117), Expect = 2e-05
Identities = 30/82 (36%), Positives = 45/82 (54%), Gaps = 8/82 (9%)
Query: 460 TRNPS-------ELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGK 512
TR PS L+G+ L K S G GF +VGG++ E + + ++ GPA L G+
Sbjct: 299 TRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGED-GEGIFVSFILAGGPADLSGE 357
Query: 513 METGDVIVSVNDTCVLGHTHAQ 534
++ GD I+SVN + G +H Q
Sbjct: 358 LQRGDQILSVNGIDLRGASHEQ 379
Score = 45.1 bits (105), Expect = 4e-04
Identities = 31/106 (29%), Positives = 54/106 (50%), Gaps = 7/106 (6%)
Query: 458 FFTRNPSELKGKFIHTKLRKSSRGFGFTVVGG-DEP----DEFLQIKSLVLDGPAALDGK 512
F N +E++ +F L + + G GF++ GG D P D + I ++ G AA DG+
Sbjct: 33 FIPVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGR 92
Query: 513 METGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPL 558
+ D I+ VN+ V +H++ V+ + G+ V L + R P+
Sbjct: 93 LRVNDCILRVNEVDVSEVSHSKAVEALKE--AGSIVRLYVRRRRPI 136
Score = 40.4 bits (93), Expect = 0.011
Identities = 21/49 (42%), Positives = 29/49 (59%), Gaps = 1/49 (2%)
Query: 142 VPCTTRSPREGEVPGVDYNFLTVKEFLDLE-QSGTLLEVGTYEGNYYGT 189
VP TTR R+ EV G DY+F+ +E ++ + Q +E G Y N YGT
Sbjct: 588 VPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGT 636
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,748,569
Number of Sequences: 37866
Number of extensions: 3010050
Number of successful extensions: 30176
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 481
Number of HSP's successfully gapped in prelim test: 288
Number of HSP's that attempted gapping in prelim test: 17273
Number of HSP's gapped (non-prelim): 6920
length of query: 1287
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1173
effective length of database: 13,930,794
effective search space: 16340821362
effective search space used: 16340821362
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.