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Search of human proteins with 73747877
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens]
(1490 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens] 2998 0.0
gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens] 2915 0.0
gi|157674354 WD repeat domain 72 [Homo sapiens] 602 e-172
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 58 8e-08
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 58 8e-08
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 58 8e-08
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 57 1e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 54 1e-06
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 53 3e-06
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 52 4e-06
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 52 4e-06
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 50 1e-05
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 50 1e-05
gi|157266266 WD repeat domain 86 [Homo sapiens] 50 2e-05
gi|32189425 WD repeat domain 69 [Homo sapiens] 49 3e-05
gi|16554629 WD repeat domain 5 [Homo sapiens] 49 4e-05
gi|16554627 WD repeat domain 5 [Homo sapiens] 49 4e-05
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 47 1e-04
gi|19913367 transducin beta-like 1Y [Homo sapiens] 47 1e-04
gi|19913365 transducin beta-like 1Y [Homo sapiens] 47 1e-04
gi|15150805 transducin beta-like 1Y [Homo sapiens] 47 1e-04
gi|55769546 PAK1 interacting protein 1 [Homo sapiens] 47 1e-04
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 46 2e-04
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 46 2e-04
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 46 2e-04
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 46 2e-04
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 46 2e-04
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 46 2e-04
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 45 4e-04
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 45 4e-04
>gi|73747877 rabconnectin-3 beta isoform 1 [Homo sapiens]
Length = 1490
Score = 2998 bits (7773), Expect = 0.0
Identities = 1490/1490 (100%), Positives = 1490/1490 (100%)
Query: 1 MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALL 60
MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALL
Sbjct: 1 MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALL 60
Query: 61 FGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFS 120
FGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFS
Sbjct: 61 FGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFS 120
Query: 121 VGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAL 180
VGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAL
Sbjct: 121 VGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAL 180
Query: 181 SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRV 240
SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRV
Sbjct: 181 SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRV 240
Query: 241 FDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDV 300
FDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDV
Sbjct: 241 FDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDV 300
Query: 301 GKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD 360
GKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD
Sbjct: 301 GKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD 360
Query: 361 TADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGR 420
TADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGR
Sbjct: 361 TADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGR 420
Query: 421 LVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARY 480
LVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARY
Sbjct: 421 LVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARY 480
Query: 481 DQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDH 540
DQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDH
Sbjct: 481 DQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDH 540
Query: 541 SVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
SVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG
Sbjct: 541 SVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
Query: 601 ITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEA 660
ITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEA
Sbjct: 601 ITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEA 660
Query: 661 SDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENL 720
SDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENL
Sbjct: 661 SDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENL 720
Query: 721 QKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEY 780
QKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEY
Sbjct: 721 QKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEY 780
Query: 781 RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSR 840
RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSR
Sbjct: 781 RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSR 840
Query: 841 GGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANT 900
GGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANT
Sbjct: 841 GGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANT 900
Query: 901 LMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQVAAPVVSARSD 960
LMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQVAAPVVSARSD
Sbjct: 901 LMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQVAAPVVSARSD 960
Query: 961 ADHSGSDPPSAPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRC 1020
ADHSGSDPPSAPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRC
Sbjct: 961 ADHSGSDPPSAPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRC 1020
Query: 1021 LEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDA 1080
LEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDA
Sbjct: 1021 LEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDA 1080
Query: 1081 SGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAE 1140
SGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAE
Sbjct: 1081 SGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAE 1140
Query: 1141 IEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRT 1200
IEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRT
Sbjct: 1141 IEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRT 1200
Query: 1201 AIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALS 1260
AIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALS
Sbjct: 1201 AIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALS 1260
Query: 1261 LIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD 1320
LIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD
Sbjct: 1261 LIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD 1320
Query: 1321 VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALY 1380
VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALY
Sbjct: 1321 VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALY 1380
Query: 1381 DIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQ 1440
DIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQ
Sbjct: 1381 DIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQ 1440
Query: 1441 LRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV 1490
LRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV
Sbjct: 1441 LRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV 1490
>gi|73747879 rabconnectin-3 beta isoform 2 [Homo sapiens]
Length = 1457
Score = 2915 bits (7557), Expect = 0.0
Identities = 1457/1490 (97%), Positives = 1457/1490 (97%), Gaps = 33/1490 (2%)
Query: 1 MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALL 60
MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALL
Sbjct: 1 MAGNSLVLPIVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALL 60
Query: 61 FGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFS 120
FGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFS
Sbjct: 61 FGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFS 120
Query: 121 VGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAL 180
VGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAL
Sbjct: 121 VGNQREGRLLCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVAL 180
Query: 181 SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRV 240
SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRV
Sbjct: 181 SVTGILKVWIVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRV 240
Query: 241 FDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDV 300
FDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDV
Sbjct: 241 FDAGDYSLLCSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDV 300
Query: 301 GKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD 360
GKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD
Sbjct: 301 GKAVENLIPPVQHILLDRKDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD 360
Query: 361 TADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGR 420
TADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGR
Sbjct: 361 TADKQGSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGR 420
Query: 421 LVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARY 480
LVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARY
Sbjct: 421 LVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARY 480
Query: 481 DQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDH 540
DQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDH
Sbjct: 481 DQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDH 540
Query: 541 SVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
SVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG
Sbjct: 541 SVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
Query: 601 ITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEA 660
ITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEA
Sbjct: 601 ITAVEILNACDEAVPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASEA 660
Query: 661 SDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENL 720
SDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENL
Sbjct: 661 SDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEASRPNTALISPENL 720
Query: 721 QKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEY 780
QKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEY
Sbjct: 721 QKASGSSDKGGSFLTGKRAAVLFQQVKETIKENIKEHLLDDEEEDEEIMRQRREESDPEY 780
Query: 781 RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSR 840
RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSR
Sbjct: 781 RSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPHCTVSFGLLSR 840
Query: 841 GGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANT 900
GGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANT
Sbjct: 841 GGHMSLMLPGYNQPACKLSHGKTEVGRKLPASEGVGKGTYGVSRAVTTQHLLSIISLANT 900
Query: 901 LMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQVAAPVVSARSD 960
LMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQ
Sbjct: 901 LMSMTNATFIGDHMKKGPTRPPRPSTPDLSKARGSPPTSSNIVQGQIKQ----------- 949
Query: 961 ADHSGSDPPSAPALHTCFLVNEGWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRC 1020
GWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRC
Sbjct: 950 ----------------------GWSQLAAMHCVMLPDLLGLDKFRPPLLEMLARRWQDRC 987
Query: 1021 LEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDA 1080
LEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDA
Sbjct: 988 LEVREAAQALLLAELRRIEQAGRKEAIDAWAPYLPQYIDHVISPGVTSEAAQTITTAPDA 1047
Query: 1081 SGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAE 1140
SGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAE
Sbjct: 1048 SGPEAKVQEEEHDLVDDDITTGCLSSVPQMKKISTSYEERRKQATAIVLLGVIGAEFGAE 1107
Query: 1141 IEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRT 1200
IEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRT
Sbjct: 1108 IEPPKLLTRPRSSSQIPEGFGLTSGGSNYSLARHTCKALTFLLLQPPSPKLPPHSTIRRT 1167
Query: 1201 AIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALS 1260
AIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALS
Sbjct: 1168 AIDLIGRGFTVWEPYMDVSAVLMGLLELCADAEKQLANITMGLPLSPAADSARSARHALS 1227
Query: 1261 LIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD 1320
LIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD
Sbjct: 1228 LIATARPPAFITTIAKEVHRHTALAANTQSQQNMHTTTLARAKGEILRVIEILIEKMPTD 1287
Query: 1321 VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALY 1380
VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALY
Sbjct: 1288 VVDLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALY 1347
Query: 1381 DIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQ 1440
DIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQ
Sbjct: 1348 DIRTGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNTSLLGSIGMLNSAPQ 1407
Query: 1441 LRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV 1490
LRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV
Sbjct: 1408 LRCIKTYQVPPVQPASPGSHNALKLARLIWTSNRNVILMAHDGKEHRFMV 1457
>gi|157674354 WD repeat domain 72 [Homo sapiens]
Length = 1102
Score = 602 bits (1552), Expect = e-172
Identities = 347/932 (37%), Positives = 546/932 (58%), Gaps = 59/932 (6%)
Query: 10 IVLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITC 69
+ LWG+KAP H I+A+++TDD TIVTG +GQ+CLW+LS EL+I+ + LLFGH+AS+TC
Sbjct: 8 VALWGQKAPPHSITAIMITDDQRTIVTGSQEGQLCLWNLSHELKISAKELLFGHSASVTC 67
Query: 70 LSKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRL 129
L++A S + YIVSA+E+GEMC+W+V++G+C+E L HT I +Y S EG L
Sbjct: 68 LARARDFSKQPYIVSAAENGEMCVWNVTNGQCVEKATLPYRHTAICYYHCSFRMTGEGWL 127
Query: 130 LCHGHYPEILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVW 189
LC G Y ++L++DA +L V++S S PDWI+ M I+ S R QED+++ +SV G LKVW
Sbjct: 128 LCCGEYQDVLIIDAKTLAVVHSFRSSQFPDWINCMCIVHSMRIQEDSLLVVSVAGELKVW 187
Query: 190 IVTSEISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYSLL 249
++S I+ +Q+ + ++E+ESK + NCQ+I FC +T+R LLVV SK W+V+D D+SLL
Sbjct: 188 DLSSSINSIQEKQDVYEKESKFLESLNCQTIRFCTYTERLLLVVFSKCWKVYDYCDFSLL 247
Query: 250 CSGPSENGQTWTGGDFVSSDKVIIWTENGQSYIYKLPASCLPASDSFRSDVGKAVENLIP 309
+ S NGQ + GG+ +++ +++IWTE+G SYIY+L S L S S G+ ++ I
Sbjct: 248 LTEVSRNGQFFAGGEVIAAHRILIWTEDGHSYIYQLLNSGL--SKSIYPADGRVLKETIY 305
Query: 310 PVQHILLDR--KDKELLICPPVTRFFYGCREYFHKLLIQGDSSGRLNIWNISD--TADKQ 365
P H+L ++ + P V + +E F+K+L G+ SGR+ +W+I D +
Sbjct: 306 P--HLLCSTSVQENKEQSRPFVMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPVSKFD 363
Query: 366 GSEEGLAMTTSISLQEAFDKLNPCPAGIIDQLSVIPNSNEPLKVTASVYIPAHGRLVCGR 425
GS + +T + +LQ+ FDK + IID S + + VT+S YIP+ +L+CG
Sbjct: 364 GSPREIPVTATWTLQDNFDKHDTMSQSIIDYFSGLKDGAGTAVVTSSEYIPSLDKLICGC 423
Query: 426 EDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYL 485
EDG+I+I A A +LL+G +++ PPH+ L+GH VT LLYPH +S++ DQ ++
Sbjct: 424 EDGTIIITQALNAAKARLLEGGSLVKDS-PPHKVLKGHHQSVTSLLYPHGLSSKLDQSWM 482
Query: 486 ISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLL 545
+SG +D VI+WDIF+ E+ H F + G +T LL+ PE R + IC V DHSV LL
Sbjct: 483 LSGDLDSCVILWDIFTEEILHKFFLEAGPVTSLLMSPEKFKLRGEQIICCVCGDHSVALL 542
Query: 546 SLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAVE 605
L K C++ A +HLFP+++IKW P +++L+VGC+D SVY+W+++TG L+R G A
Sbjct: 543 HLEGKSCLLHARKHLFPVRMIKWHPVENFLIVGCADDSVYIWEIETGTLERHETGERARI 602
Query: 606 ILNACDEA------VPAAVDSLSHPAVNLKQAMTRRSLAALKNMAHHKLQTLATNLLASE 659
ILN CD++ +P A ++L H ++ + + + ++L L L E
Sbjct: 603 ILNCCDDSQLVKSVLPIASETLKHKSIEQRSS------------SPYQLGPLPCPGLQVE 650
Query: 660 ASDKGNLPKYSHNSLMVQAIKTNLTDPDIHVLFFDVEALIIQLLTEEAS--RPNTALISP 717
+S K K+ V +KT ++ H+L FD+E L+ LL S +++
Sbjct: 651 SSCKVTDAKFCPRPFNVLPVKTKWSNVGFHILLFDLENLVELLLPTPLSDVDSSSSFYGG 710
Query: 718 ENLQKASGSSDKGGSFLTGKRAA-------VLFQQVKETIKENIKEHLLDDEEEDEEIMR 770
E L++A + +K L + A L + + E++ + ++ + EE++ I R
Sbjct: 711 EVLRRAKSTVEKKTLTLRKSKTACGPLSAEALAKPITESLAQG--DNTIKFSEENDGIKR 768
Query: 771 QRREESDPEYRSSKSKPLTLLEYNLTMDTAKLFMSCLHAWGLNEVLDEVCLDRLGMLKPH 830
Q++ + + + KP ++ +LT+DTAKLF+SCL WG+++ LD +C+ L +LK
Sbjct: 769 QKKMKIS---KKMQPKPSRKVDASLTIDTAKLFLSCLLPWGVDKDLDYLCIKHLNILKLQ 825
Query: 831 CTVSFGLLSRGGHMSLMLPGY---NQPACKLSHGKTEVGRK-----------LPASEGVG 876
+S G+ + SLMLPG+ N K G RK LP G+
Sbjct: 826 GPISLGISLNEDNFSLMLPGWDLCNSGMIKDYSGVNLFSRKVLDLSDKYTATLPNQVGIP 885
Query: 877 KGTY----GVSRAVTTQHLLSIISLANTLMSM 904
+G + + T +LLS + L N L++M
Sbjct: 886 RGLENNCDSLRESDTIVYLLSRLFLVNKLVNM 917
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 57.8 bits (138), Expect = 8e-08
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 17/146 (11%)
Query: 454 WPPHR-----TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508
W HR +L H N V C + D R ++S D +V +WD S E H +
Sbjct: 92 WATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTVKLWDKSSRECVHSY 145
Query: 509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKW 568
C HGG +T + P CI + D++V + +R + + H + + +
Sbjct: 146 CEHGGFVTYVDFHPSGT------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 199
Query: 569 RPSDDYLVVGCSDGSVYVWQMDTGAL 594
PS +YL+ SD ++ + + G L
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRL 225
Score = 45.1 bits (105), Expect = 5e-04
Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1359 VSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDS 1417
+S++ + + + ++ + D+ G+ T+HGH+GP T VAF+ G Y A+ +D
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS-GGSDE 255
Query: 1418 HISFWQMNTSLL--GSIGMLNSAPQLRCIKTYQVPPVQ-PASPG 1458
+ W+ N ++ G + + P +P V P PG
Sbjct: 256 QVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPG 299
Score = 38.9 bits (89), Expect = 0.037
Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACA 75
+A T + +V DG + VT D + +W + + LF + I + A
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW------ATHRQKFLFSLSQHINWVRCAKF 115
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFY 117
S D + IVSAS+ + LWD S C+ C H G Y
Sbjct: 116 SPDGRLIVSASDDKTVKLWDKSSRECVH---SYCEHGGFVTY 154
Score = 32.0 bits (71), Expect = 4.6
Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 1344 KGLQECFPAICRF----YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPIT 1398
K +EC + C V ++ IA +V ++D+RT + Q H +
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
Query: 1399 AVAFAPDGRYLATYSN 1414
++F P G YL T S+
Sbjct: 196 GLSFHPSGNYLITASS 211
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 57.8 bits (138), Expect = 8e-08
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 17/146 (11%)
Query: 454 WPPHR-----TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508
W HR +L H N V C + D R ++S D +V +WD S E H +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKW 568
C HGG +T + P CI + D++V + +R + + H + + +
Sbjct: 184 CEHGGFVTYVDFHPSGT------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 569 RPSDDYLVVGCSDGSVYVWQMDTGAL 594
PS +YL+ SD ++ + + G L
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRL 263
Score = 43.1 bits (100), Expect = 0.002
Identities = 19/72 (26%), Positives = 39/72 (54%), Gaps = 2/72 (2%)
Query: 1359 VSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDS 1417
+S++ + + + ++ + D+ G+ T+HGH+GP T VAF+ G Y A+ +D
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS-GGSDE 293
Query: 1418 HISFWQMNTSLL 1429
+ W+ N ++
Sbjct: 294 QVMVWKSNFDIV 305
Score = 38.9 bits (89), Expect = 0.037
Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACA 75
+A T + +V DG + VT D + +W + + LF + I + A
Sbjct: 100 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW------ATHRQKFLFSLSQHINWVRCAKF 153
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFY 117
S D + IVSAS+ + LWD S C+ C H G Y
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVH---SYCEHGGFVTY 192
Score = 34.7 bits (78), Expect = 0.71
Identities = 28/130 (21%), Positives = 50/130 (38%), Gaps = 12/130 (9%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
R +GHR+ VTC V + + L SG +D +++W + + F H +T
Sbjct: 13 RHFKGHRDAVTC------VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
+ P H + S + D +V + K + H ++ + + V
Sbjct: 67 VNFSPSG------HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 578 GCSDGSVYVW 587
D +V VW
Sbjct: 121 ASDDKTVKVW 130
Score = 32.0 bits (71), Expect = 4.6
Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 1344 KGLQECFPAICRF----YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPIT 1398
K +EC + C V ++ IA +V ++D+RT + Q H +
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 1399 AVAFAPDGRYLATYSN 1414
++F P G YL T S+
Sbjct: 234 GLSFHPSGNYLITASS 249
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 57.8 bits (138), Expect = 8e-08
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 17/146 (11%)
Query: 454 WPPHR-----TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508
W HR +L H N V C + D R ++S D +V +WD S E H +
Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSP------DGRLIVSASDDKTVKLWDKSSRECVHSY 183
Query: 509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKW 568
C HGG +T + P CI + D++V + +R + + H + + +
Sbjct: 184 CEHGGFVTYVDFHPSGT------CIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSF 237
Query: 569 RPSDDYLVVGCSDGSVYVWQMDTGAL 594
PS +YL+ SD ++ + + G L
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRL 263
Score = 45.1 bits (105), Expect = 5e-04
Identities = 26/104 (25%), Positives = 49/104 (47%), Gaps = 5/104 (4%)
Query: 1359 VSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDS 1417
+S++ + + + ++ + D+ G+ T+HGH+GP T VAF+ G Y A+ +D
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFAS-GGSDE 293
Query: 1418 HISFWQMNTSLL--GSIGMLNSAPQLRCIKTYQVPPVQ-PASPG 1458
+ W+ N ++ G + + P +P V P PG
Sbjct: 294 QVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPG 337
Score = 38.9 bits (89), Expect = 0.037
Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 9/102 (8%)
Query: 16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACA 75
+A T + +V DG + VT D + +W + + LF + I + A
Sbjct: 100 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW------ATHRQKFLFSLSQHINWVRCAKF 153
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFY 117
S D + IVSAS+ + LWD S C+ C H G Y
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVH---SYCEHGGFVTY 192
Score = 34.7 bits (78), Expect = 0.71
Identities = 28/130 (21%), Positives = 50/130 (38%), Gaps = 12/130 (9%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
R +GHR+ VTC V + + L SG +D +++W + + F H +T
Sbjct: 13 RHFKGHRDAVTC------VDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
+ P H + S + D +V + K + H ++ + + V
Sbjct: 67 VNFSPSG------HLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVT 120
Query: 578 GCSDGSVYVW 587
D +V VW
Sbjct: 121 ASDDKTVKVW 130
Score = 32.0 bits (71), Expect = 4.6
Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 1344 KGLQECFPAICRF----YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPIT 1398
K +EC + C V ++ IA +V ++D+RT + Q H +
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 1399 AVAFAPDGRYLATYSN 1414
++F P G YL T S+
Sbjct: 234 GLSFHPSGNYLITASS 249
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 57.4 bits (137), Expect = 1e-07
Identities = 31/88 (35%), Positives = 49/88 (55%), Gaps = 4/88 (4%)
Query: 16 KAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLS--KA 73
K H + ++ + DG + +GC +GQI LWD S Q+ L GH+ IT LS
Sbjct: 153 KGHRHWVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVG--RTLAGHSKWITGLSWEPL 210
Query: 74 CASSDKQYIVSASESGEMCLWDVSDGRC 101
A+ + +Y+ S+S+ G + +WD + GRC
Sbjct: 211 HANPECRYVASSSKDGSVRIWDTTAGRC 238
Score = 38.5 bits (88), Expect = 0.049
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 9/107 (8%)
Query: 485 LISGGVDFSVIIWDIFSGEMKHIFCVHGGE--ITQLLVPPENCSARVQHCICSVASDHSV 542
L+SG DF++ +W + + K + + G + I Q+L P++ + S + D S+
Sbjct: 344 LVSGSDDFTLFLWSP-AEDKKPLTRMTGHQALINQVLFSPDS------RIVASASFDKSI 396
Query: 543 GLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQM 589
L R K + H+ + I W LV G SD ++ VW +
Sbjct: 397 KLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDV 443
Score = 37.0 bits (84), Expect = 0.14
Identities = 18/51 (35%), Positives = 32/51 (62%), Gaps = 3/51 (5%)
Query: 1378 ALYDIR--TGKCQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
A++ +R T ++ GH + +VAF+P G+YLA+ S D+ + FW ++T
Sbjct: 96 AIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGSG-DTTVRFWDLST 145
Score = 37.0 bits (84), Expect = 0.14
Identities = 33/113 (29%), Positives = 54/113 (47%), Gaps = 24/113 (21%)
Query: 1359 VSYYERNHRIAVGARHGSVALYDIRTGK--CQTIHGHKGPITAVAFA-----PDGRYLAT 1411
+S+ ++A G ++G + L+D TGK +T+ GH IT +++ P+ RY+A+
Sbjct: 162 ISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVAS 221
Query: 1412 YSNTDSHISFW---------------QMNTSL-LGSIGMLNSAPQLRCIKTYQ 1448
S+ D + W Q T L G G+L SA Q R IK ++
Sbjct: 222 -SSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWR 273
Score = 35.0 bits (79), Expect = 0.54
Identities = 22/61 (36%), Positives = 30/61 (49%), Gaps = 1/61 (1%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL GH +T L + + A + RY+ S D SV IWD +G + I H +T
Sbjct: 193 RTLAGHSKWITGLSW-EPLHANPECRYVASSSKDGSVRIWDTTAGRCERILTGHTQSVTC 251
Query: 518 L 518
L
Sbjct: 252 L 252
Score = 33.1 bits (74), Expect = 2.1
Identities = 23/115 (20%), Positives = 47/115 (40%), Gaps = 6/115 (5%)
Query: 474 HQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCI 533
+QV D R + S D S+ +WD +G+ H + Q+ ++ +
Sbjct: 376 NQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADS------RLL 429
Query: 534 CSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQ 588
S +SD ++ + ++ +K M H + + W P + G D + +W+
Sbjct: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIWR 484
Score = 32.7 bits (73), Expect = 2.7
Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 6/75 (8%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQY 81
I+ VL + D + + D I LWD + A L GH A++ ++ S+D +
Sbjct: 375 INQVLFSPDSRIVASASFDKSIKLWDGRTGKYL---ASLRGHVAAVYQIAW---SADSRL 428
Query: 82 IVSASESGEMCLWDV 96
+VS S + +WDV
Sbjct: 429 LVSGSSDSTLKVWDV 443
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 53.5 bits (127), Expect = 1e-06
Identities = 32/106 (30%), Positives = 53/106 (50%), Gaps = 4/106 (3%)
Query: 1361 YYERNHRIAVGARHGSVALYDIRTGKCQTIH-GHKGPITAVAFAPDGRYLATYSNTDSHI 1419
++ ++ +A G+ +V L+D+ G C I GHKGPI ++ F+P+GR+LAT TD +
Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLAT-GATDGRV 693
Query: 1420 SFWQMNTSLLGSIGMLNSAPQLRCIKTYQVPPVQPASPGSHNALKL 1465
W + L+ +G L C + AS N ++L
Sbjct: 694 LLWDIGHGLM--VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRL 737
Score = 44.3 bits (103), Expect = 9e-04
Identities = 25/111 (22%), Positives = 49/111 (44%), Gaps = 6/111 (5%)
Query: 484 YLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVG 543
Y +SGG D +W + IF H ++ P + + + + ++D +V
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNS------NYVATGSADRTVR 652
Query: 544 LLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGAL 594
L + C+ + + H PI + + P+ +L G +DG V +W + G +
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/85 (29%), Positives = 40/85 (47%), Gaps = 9/85 (10%)
Query: 11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCL 70
+ G K P H ++ + +G + TG DG++ LWD+ L + L GHT ++ L
Sbjct: 664 IFTGHKGPIHSLT---FSPNGRFLATGATDGRVLLWDIGHGLMVGE---LKGHTDTVCSL 717
Query: 71 SKACASSDKQYIVSASESGEMCLWD 95
S D + + S S + LWD
Sbjct: 718 R---FSRDGEILASGSMDNTVRLWD 739
Score = 40.4 bits (93), Expect = 0.013
Identities = 30/134 (22%), Positives = 51/134 (38%), Gaps = 12/134 (8%)
Query: 454 WPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGG 513
+ P R GH V C + + Y+ +G D +V +WD+ +G IF H G
Sbjct: 617 YQPLRIFAGHLADVNCTRF------HPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKG 670
Query: 514 EITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDD 573
I L P + + A+D V L + + H + +++ +
Sbjct: 671 PIHSLTFSPNG------RFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGE 724
Query: 574 YLVVGCSDGSVYVW 587
L G D +V +W
Sbjct: 725 ILASGSMDNTVRLW 738
Score = 38.1 bits (87), Expect = 0.064
Identities = 35/153 (22%), Positives = 60/153 (39%), Gaps = 37/153 (24%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLW--------------DLSV--------------ELQ 53
++AV +TDD + I G D + +W DLS+ E
Sbjct: 473 LTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKT 532
Query: 54 INPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWDVSDGRCI------EFTKL 107
+ +L+GH+ + A S D+ Y++S+SE G + LW + C+ +
Sbjct: 533 ASELKILYGHSGPVY---GASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVW 589
Query: 108 ACTHTGIQFYQFSVGNQREGRLLCHGHYPEILV 140
+ +Y S G+ R RL HY + +
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRI 622
Score = 34.7 bits (78), Expect = 0.71
Identities = 13/37 (35%), Positives = 22/37 (59%), Gaps = 1/37 (2%)
Query: 1390 IHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
++GH GP+ +F+PD YL + S+ D + W + T
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLS-SSEDGTVRLWSLQT 574
Score = 34.7 bits (78), Expect = 0.71
Identities = 20/72 (27%), Positives = 29/72 (40%), Gaps = 6/72 (8%)
Query: 31 GATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESGE 90
G V+G HD LW P + GH A + C + Y+ + S
Sbjct: 597 GYYFVSGGHDRVARLWATD---HYQPLRIFAGHLADVNCTR---FHPNSNYVATGSADRT 650
Query: 91 MCLWDVSDGRCI 102
+ LWDV +G C+
Sbjct: 651 VRLWDVLNGNCV 662
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 52.8 bits (125), Expect = 3e-06
Identities = 42/189 (22%), Positives = 72/189 (38%), Gaps = 12/189 (6%)
Query: 454 WPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGG 513
W +R + GH V C ++ ++ ++G D ++ IWD+ SG++K H
Sbjct: 194 WKLYRVISGHLGWVRC------IAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHIS 247
Query: 514 EITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDD 573
+ ++V S R + + S D V L K I HL + + P+ D
Sbjct: 248 TVRGVIV-----STRSPY-LFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTID 301
Query: 574 YLVVGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAVPAAVDSLSHPAVNLKQAMT 633
LV D + +W + T A + G T C A P + + L +
Sbjct: 302 VLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361
Query: 634 RRSLAALKN 642
++ L N
Sbjct: 362 GKTRVTLTN 370
Score = 37.0 bits (84), Expect = 0.14
Identities = 30/134 (22%), Positives = 56/134 (41%), Gaps = 14/134 (10%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GH N V V + + +I+G D ++ +WD+ +G+ + H + +
Sbjct: 325 TLSGHTNAVAT------VRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAV 378
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
++ P +H + S ++ + I S H I + SD LV G
Sbjct: 379 VLHP-------RHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVN-SDGVLVSG 430
Query: 579 CSDGSVYVWQMDTG 592
+G++++W TG
Sbjct: 431 ADNGTMHLWDWRTG 444
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 52.0 bits (123), Expect = 4e-06
Identities = 41/140 (29%), Positives = 59/140 (42%), Gaps = 17/140 (12%)
Query: 461 RGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLV 520
RGH V L + + +L+SG D S+ WD+ SG IF H G IT
Sbjct: 450 RGHAGSVRALFLCEE------ENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTIT---- 499
Query: 521 PPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCS 580
C ++ + S D V + + KC+ RH PI + R +D Y+V C
Sbjct: 500 ----CMDLCKNRLVSGGRDCQVKVWDVDTGKCLK-TFRHKDPI--LATRINDTYIVSSCE 552
Query: 581 DGSVYVWQMDTGALDRCVMG 600
G V VW + L + + G
Sbjct: 553 RGLVKVWHIAMAQLVKTLSG 572
Score = 38.1 bits (87), Expect = 0.064
Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 8/82 (9%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQY 81
+ A+ L ++ +++G +D I WDL + + GH +ITC+ K
Sbjct: 456 VRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTR---IFGGHQGTITCMDLC-----KNR 507
Query: 82 IVSASESGEMCLWDVSDGRCIE 103
+VS ++ +WDV G+C++
Sbjct: 508 LVSGGRDCQVKVWDVDTGKCLK 529
Score = 31.6 bits (70), Expect = 6.0
Identities = 14/34 (41%), Positives = 19/34 (55%)
Query: 1366 HRIAVGARHGSVALYDIRTGKCQTIHGHKGPITA 1399
+R+ G R V ++D+ TGKC HK PI A
Sbjct: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILA 539
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 52.0 bits (123), Expect = 4e-06
Identities = 41/140 (29%), Positives = 59/140 (42%), Gaps = 17/140 (12%)
Query: 461 RGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLV 520
RGH V L + + +L+SG D S+ WD+ SG IF H G IT
Sbjct: 450 RGHAGSVRALFLCEE------ENFLLSGSYDLSIRYWDLKSGVCTRIFGGHQGTIT---- 499
Query: 521 PPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCS 580
C ++ + S D V + + KC+ RH PI + R +D Y+V C
Sbjct: 500 ----CMDLCKNRLVSGGRDCQVKVWDVDTGKCLK-TFRHKDPI--LATRINDTYIVSSCE 552
Query: 581 DGSVYVWQMDTGALDRCVMG 600
G V VW + L + + G
Sbjct: 553 RGLVKVWHIAMAQLVKTLSG 572
Score = 38.1 bits (87), Expect = 0.064
Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 8/82 (9%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQY 81
+ A+ L ++ +++G +D I WDL + + GH +ITC+ K
Sbjct: 456 VRALFLCEEENFLLSGSYDLSIRYWDLKSGVCTR---IFGGHQGTITCMDLC-----KNR 507
Query: 82 IVSASESGEMCLWDVSDGRCIE 103
+VS ++ +WDV G+C++
Sbjct: 508 LVSGGRDCQVKVWDVDTGKCLK 529
Score = 31.6 bits (70), Expect = 6.0
Identities = 14/34 (41%), Positives = 19/34 (55%)
Query: 1366 HRIAVGARHGSVALYDIRTGKCQTIHGHKGPITA 1399
+R+ G R V ++D+ TGKC HK PI A
Sbjct: 506 NRLVSGGRDCQVKVWDVDTGKCLKTFRHKDPILA 539
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 50.4 bits (119), Expect = 1e-05
Identities = 36/143 (25%), Positives = 61/143 (42%), Gaps = 12/143 (8%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL GH+ + C L H ++ SG D ++ +WDI + H +
Sbjct: 99 RTLMGHKANI-CSLDFHPYG-----EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
L P+ + S A DH+V L L K + H P+ V+++ P++ L
Sbjct: 153 LRFSPDG------KWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLAS 206
Query: 578 GCSDGSVYVWQMDTGALDRCVMG 600
G SD ++ W ++ + C+ G
Sbjct: 207 GSSDRTIRFWDLEKFQVVSCIEG 229
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/129 (24%), Positives = 56/129 (43%), Gaps = 13/129 (10%)
Query: 461 RGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLV 520
RGH V CL + D ++L S D +V +WD+ +G+M F H G + +
Sbjct: 144 RGHSQAVRCLRFSP------DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
Query: 521 PPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCS 580
P ++ + S +SD ++ L + + + P++ + + P L GC
Sbjct: 198 HPN------EYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQ 251
Query: 581 DG-SVYVWQ 588
D VY W+
Sbjct: 252 DSLRVYGWE 260
Score = 43.5 bits (101), Expect = 0.002
Identities = 18/62 (29%), Positives = 33/62 (53%)
Query: 539 DHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCV 598
D V L S+ + CIM + H P++ ++ ++ +V G GS+ VW ++ + R +
Sbjct: 42 DCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL 101
Query: 599 MG 600
MG
Sbjct: 102 MG 103
Score = 38.5 bits (88), Expect = 0.049
Identities = 19/58 (32%), Positives = 35/58 (60%), Gaps = 2/58 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQM 1424
I G++ GS+ ++D+ K +T+ GHK I ++ F P G ++A+ S D++I W +
Sbjct: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ-DTNIKLWDI 134
Score = 37.0 bits (84), Expect = 0.14
Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKCQT-IHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQM 1424
+A A +V L+D+ GK + GH GP+ V F P+ YL ++D I FW +
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPN-EYLLASGSSDRTIRFWDL 218
Score = 36.2 bits (82), Expect = 0.24
Identities = 18/65 (27%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKCQ-TIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
+A G++ ++ L+DIR C GH + + F+PDG++LA+ ++ D + W +
Sbjct: 120 VASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD-DHTVKLWDLTA 178
Query: 1427 SLLGS 1431
+ S
Sbjct: 179 GKMMS 183
Score = 32.7 bits (73), Expect = 2.7
Identities = 21/80 (26%), Positives = 41/80 (51%), Gaps = 6/80 (7%)
Query: 23 SAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYI 82
S VL G + TG D ++ LW ++ + N L GHT+ + + ++ ++ I
Sbjct: 25 SLVLGKASGRLLATGGDDCRVNLWSIN---KPNCIMSLTGHTSPVESVR---LNTPEELI 78
Query: 83 VSASESGEMCLWDVSDGRCI 102
V+ S+SG + +WD+ + +
Sbjct: 79 VAGSQSGSIRVWDLEAAKIL 98
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 50.4 bits (119), Expect = 1e-05
Identities = 45/182 (24%), Positives = 76/182 (41%), Gaps = 15/182 (8%)
Query: 456 PHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEI 515
P +T +GH N+V + + + L S D ++ IW + H H EI
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNL------LASCSDDMTLKIWSMKQDNCVHDLQAHNKEI 394
Query: 516 TQLLVPP-----ENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRP 570
+ P N +A + + S + D +V L + CI ++H P+ + + P
Sbjct: 395 YTIKWSPTGPGTNNPNANLM--LASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP 452
Query: 571 SDDYLVVGCSDGSVYVWQMDTGALDRCVMGITAV-EIL-NACDEAVPAAVDSLSHPAVNL 628
YL G D V++W TGAL G + E+ NA + V A+ S ++L
Sbjct: 453 DGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
Query: 629 KQ 630
++
Sbjct: 513 RK 514
Score = 49.7 bits (117), Expect = 2e-05
Identities = 31/120 (25%), Positives = 52/120 (43%), Gaps = 10/120 (8%)
Query: 484 YLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVG 543
+++S GVD + IIWD +GE K F H P + + + S ++D +
Sbjct: 280 FILSAGVDKTTIIWDAHTGEAKQQFPFHS-------APALDVDWQSNNTFASCSTDMCIH 332
Query: 544 LLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMGITA 603
+ L + + I H + IKW P+ + L D ++ +W M D CV + A
Sbjct: 333 VCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQ---DNCVHDLQA 389
Score = 44.3 bits (103), Expect = 9e-04
Identities = 24/66 (36%), Positives = 37/66 (56%), Gaps = 2/66 (3%)
Query: 1365 NHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQ 1423
N +A + +V L+D+ G C T+ H+ P+ +VAF+PDGRYLA+ + D + W
Sbjct: 412 NLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLAS-GSFDKCVHIWN 470
Query: 1424 MNTSLL 1429
T L
Sbjct: 471 TQTGAL 476
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 50.1 bits (118), Expect = 2e-05
Identities = 36/148 (24%), Positives = 57/148 (38%), Gaps = 16/148 (10%)
Query: 457 HRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT 516
H+TLRGH V CL+ + +G D ++ WDI SGE +F H G +
Sbjct: 186 HQTLRGHTGAVLCLVLDTPGHTAF------TGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Query: 517 QLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLV 576
C V + S ++D +V +C+ + H + +K+ L
Sbjct: 240 --------CLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAGT--LF 289
Query: 577 VGCSDGSVYVWQMDTGALDRCVMGITAV 604
G D + +G L R G T +
Sbjct: 290 TGSGDACARAFDAQSGELRRVFRGHTFI 317
Score = 32.0 bits (71), Expect = 4.6
Identities = 23/82 (28%), Positives = 39/82 (47%), Gaps = 8/82 (9%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQY 81
I+ + L+ DG ++TG DG LW + ALL GH + +T C D+
Sbjct: 18 INWLSLSPDGQRLLTGSEDGTARLWSTA---DGQCCALLQGHESYVT----FCQLEDEAA 70
Query: 82 IVSASESGEMCLWDVSDGRCIE 103
+++ + WDV G+C++
Sbjct: 71 FTCSADC-TIRRWDVLTGQCLQ 91
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 49.3 bits (116), Expect = 3e-05
Identities = 30/126 (23%), Positives = 55/126 (43%), Gaps = 6/126 (4%)
Query: 477 SARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSARVQHCICSV 536
S +D +++G +D + +WD +G+ H EI ++C I +
Sbjct: 268 SFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL------DSCFDYTGKLIATA 321
Query: 537 ASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDR 596
++D + + S +KCI H I I + P ++L+ G SD + +W TG +
Sbjct: 322 SADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQ 381
Query: 597 CVMGIT 602
+ G T
Sbjct: 382 VLEGHT 387
Score = 48.1 bits (113), Expect = 6e-05
Identities = 33/142 (23%), Positives = 61/142 (42%), Gaps = 11/142 (7%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GHRN V + + + + + +G D + +W + +G+ H F H EI L
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDK-----IATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCL 183
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
P++ + + + D + L ++ + + H I + + S D ++ G
Sbjct: 184 SFNPQST------LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
Query: 579 CSDGSVYVWQMDTGALDRCVMG 600
D +V VW DTG ++G
Sbjct: 238 SFDHTVVVWDADTGRKVNILIG 259
Score = 42.4 bits (98), Expect = 0.003
Identities = 43/188 (22%), Positives = 77/188 (40%), Gaps = 18/188 (9%)
Query: 457 HRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT 516
+ T RGH ++ CL + Q + +G +D + +WDI +GE + H EI
Sbjct: 170 YHTFRGHTAEIVCLSFNPQ------STLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEII 223
Query: 517 QLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLV 576
L N S I + + DH+V + + + + H I + ++
Sbjct: 224 SLSF---NTSG---DRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLIL 277
Query: 577 VGCSDGSVYVWQMDTGALDRCVMGITA--VEILNACDEAVPAAVDSLS-HPAVNLKQAMT 633
G D + +W G +CV +T EIL++C + + + S + A T
Sbjct: 278 TGSMDKTCKLWDATNG---KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAAT 334
Query: 634 RRSLAALK 641
R+ +A L+
Sbjct: 335 RKCIAKLE 342
Score = 41.6 bits (96), Expect = 0.006
Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 6/81 (7%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQY 81
I ++ G I+TG D + +WD ++N +L GH A I S A + D
Sbjct: 222 IISLSFNTSGDRIITGSFDHTVVVWDADTGRKVN---ILIGHCAEI---SSASFNWDCSL 275
Query: 82 IVSASESGEMCLWDVSDGRCI 102
I++ S LWD ++G+C+
Sbjct: 276 ILTGSMDKTCKLWDATNGKCV 296
Score = 36.6 bits (83), Expect = 0.19
Identities = 18/60 (30%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
IA + G+ ++ T KC + GH+G I+ ++F P G +L T ++D W T
Sbjct: 318 IATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLT-GSSDKTARIWDAQT 376
Score = 34.7 bits (78), Expect = 0.71
Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 2/59 (3%)
Query: 1367 RIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQM 1424
+IA G+ + L+ + TGKC T GH I ++F P +AT + D+ W +
Sbjct: 149 KIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVAT-GSMDTTAKLWDI 206
Score = 32.0 bits (71), Expect = 4.6
Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 5/80 (6%)
Query: 22 ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQY 81
++ V L G+ +TG +D LWD + ++N L GH + ++ DK
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELN---TLEGHRNVVYAIAFNNPYGDK-- 149
Query: 82 IVSASESGEMCLWDVSDGRC 101
I + S LW V G+C
Sbjct: 150 IATGSFDKTCKLWSVETGKC 169
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 48.9 bits (115), Expect = 4e-05
Identities = 52/233 (22%), Positives = 97/233 (41%), Gaps = 37/233 (15%)
Query: 19 THCISAVLLTDDGATIVTGCHDGQICLW---DLSVELQINPRALLFGHTASITCLSKACA 75
T +S+V + +G + + D I +W D E I+ GH I S
Sbjct: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS------GHKLGI---SDVAW 95
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRLLCHGHY 135
SSD +VSAS+ + +WDVS G+C++ K G Y F + L+ G +
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLK------GHSNYVFCCNFNPQSNLIVSGSF 149
Query: 136 PE-ILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSE 194
E + + D + + L +L + P +S + +R +V+ S G+ ++W +
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDP-----VSAVHFNR-DGSLIVSSSYDGLCRIW----D 199
Query: 195 ISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYS 247
+ Q + + ++++ P +SF F+ ++ + DYS
Sbjct: 200 TASGQCLKTLIDDDNPP--------VSFVKFSPNGKYILAATLDNTLKLWDYS 244
Score = 41.6 bits (96), Expect = 0.006
Identities = 29/135 (21%), Positives = 55/135 (40%), Gaps = 12/135 (8%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
+T+ GH+ ++ V+ D L+S D ++ IWD+ SG+ H +
Sbjct: 81 KTISGHKLGIS------DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC 134
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
P++ + I S + D SV + ++ KC+ H P+ + + +V
Sbjct: 135 CNFNPQS------NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 578 GCSDGSVYVWQMDTG 592
DG +W +G
Sbjct: 189 SSYDGLCRIWDTASG 203
Score = 39.3 bits (90), Expect = 0.029
Identities = 43/199 (21%), Positives = 69/199 (34%), Gaps = 58/199 (29%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHG----- 512
+TL+GH N V C + Q ++SG D SV IWD+ +G+ H
Sbjct: 123 KTLKGHSNYVFCCNFNPQ------SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 513 --------------------------GEITQLLVPPENCSARVQHC------ICSVASDH 540
G+ + L+ +N I + D+
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236
Query: 541 SVGLLSLREKKCIMLASRHL---------FPIQVIKWRPSDDYLVVGCSDGSVYVWQMDT 591
++ L + KC+ + H F + KW +V G D VY+W + T
Sbjct: 237 TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQT 290
Query: 592 GALDRCVMGITAVEILNAC 610
+ + + G T V I AC
Sbjct: 291 KEIVQKLQGHTDVVISTAC 309
Score = 38.9 bits (89), Expect = 0.037
Identities = 20/67 (29%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 1357 YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNT 1415
+ ++ +++ I G+ SV ++D++TGKC +T+ H P++AV F DG + + S+
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS-SSY 191
Query: 1416 DSHISFW 1422
D W
Sbjct: 192 DGLCRIW 198
Score = 38.1 bits (87), Expect = 0.064
Identities = 27/134 (20%), Positives = 54/134 (40%), Gaps = 12/134 (8%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GH V+ + + + +L S D + IW + G+ + H I+ +
Sbjct: 40 TLAGHTKAVSSVKFSP------NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
++ + + S + D ++ + + KC+ H + + P + +V G
Sbjct: 94 AWSSDS------NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 579 CSDGSVYVWQMDTG 592
D SV +W + TG
Sbjct: 148 SFDESVRIWDVKTG 161
Score = 37.7 bits (86), Expect = 0.083
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 13/98 (13%)
Query: 18 PTHC--ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACA 75
P H +SAV DG+ IV+ +DG +WD + + + L+ ++ +
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--KTLIDDDNPPVSFVK---F 222
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTG 113
S + +YI++A+ + LWD S G+C++ T+TG
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLK------TYTG 254
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 48.9 bits (115), Expect = 4e-05
Identities = 52/233 (22%), Positives = 97/233 (41%), Gaps = 37/233 (15%)
Query: 19 THCISAVLLTDDGATIVTGCHDGQICLW---DLSVELQINPRALLFGHTASITCLSKACA 75
T +S+V + +G + + D I +W D E I+ GH I S
Sbjct: 45 TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTIS------GHKLGI---SDVAW 95
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRLLCHGHY 135
SSD +VSAS+ + +WDVS G+C++ K G Y F + L+ G +
Sbjct: 96 SSDSNLLVSASDDKTLKIWDVSSGKCLKTLK------GHSNYVFCCNFNPQSNLIVSGSF 149
Query: 136 PE-ILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVWIVTSE 194
E + + D + + L +L + P +S + +R +V+ S G+ ++W +
Sbjct: 150 DESVRIWDVKTGKCLKTLPAHSDP-----VSAVHFNR-DGSLIVSSSYDGLCRIW----D 199
Query: 195 ISDMQDTEPIFEEESKPIYCQNCQSISFCAFTQRSLLVVCSKYWRVFDAGDYS 247
+ Q + + ++++ P +SF F+ ++ + DYS
Sbjct: 200 TASGQCLKTLIDDDNPP--------VSFVKFSPNGKYILAATLDNTLKLWDYS 244
Score = 41.6 bits (96), Expect = 0.006
Identities = 29/135 (21%), Positives = 55/135 (40%), Gaps = 12/135 (8%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
+T+ GH+ ++ V+ D L+S D ++ IWD+ SG+ H +
Sbjct: 81 KTISGHKLGIS------DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC 134
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
P++ + I S + D SV + ++ KC+ H P+ + + +V
Sbjct: 135 CNFNPQS------NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS 188
Query: 578 GCSDGSVYVWQMDTG 592
DG +W +G
Sbjct: 189 SSYDGLCRIWDTASG 203
Score = 39.3 bits (90), Expect = 0.029
Identities = 43/199 (21%), Positives = 69/199 (34%), Gaps = 58/199 (29%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHG----- 512
+TL+GH N V C + Q ++SG D SV IWD+ +G+ H
Sbjct: 123 KTLKGHSNYVFCCNFNPQ------SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 513 --------------------------GEITQLLVPPENCSARVQHC------ICSVASDH 540
G+ + L+ +N I + D+
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236
Query: 541 SVGLLSLREKKCIMLASRHL---------FPIQVIKWRPSDDYLVVGCSDGSVYVWQMDT 591
++ L + KC+ + H F + KW +V G D VY+W + T
Sbjct: 237 TLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKW------IVSGSEDNLVYIWNLQT 290
Query: 592 GALDRCVMGITAVEILNAC 610
+ + + G T V I AC
Sbjct: 291 KEIVQKLQGHTDVVISTAC 309
Score = 38.9 bits (89), Expect = 0.037
Identities = 20/67 (29%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 1357 YMVSYYERNHRIAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNT 1415
+ ++ +++ I G+ SV ++D++TGKC +T+ H P++AV F DG + + S+
Sbjct: 133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVS-SSY 191
Query: 1416 DSHISFW 1422
D W
Sbjct: 192 DGLCRIW 198
Score = 38.1 bits (87), Expect = 0.064
Identities = 27/134 (20%), Positives = 54/134 (40%), Gaps = 12/134 (8%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GH V+ + + + +L S D + IW + G+ + H I+ +
Sbjct: 40 TLAGHTKAVSSVKFSP------NGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDV 93
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
++ + + S + D ++ + + KC+ H + + P + +V G
Sbjct: 94 AWSSDS------NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 579 CSDGSVYVWQMDTG 592
D SV +W + TG
Sbjct: 148 SFDESVRIWDVKTG 161
Score = 37.7 bits (86), Expect = 0.083
Identities = 27/98 (27%), Positives = 49/98 (50%), Gaps = 13/98 (13%)
Query: 18 PTHC--ISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACA 75
P H +SAV DG+ IV+ +DG +WD + + + L+ ++ +
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL--KTLIDDDNPPVSFVK---F 222
Query: 76 SSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTG 113
S + +YI++A+ + LWD S G+C++ T+TG
Sbjct: 223 SPNGKYILAATLDNTLKLWDYSKGKCLK------TYTG 254
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 47.4 bits (111), Expect = 1e-04
Identities = 36/153 (23%), Positives = 63/153 (41%), Gaps = 19/153 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
R L GH ++C + D +++ D + +WDI +G+ F H G++
Sbjct: 137 RELAGHTGYLSCCRF-------LDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMS 189
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
L + P+ S A D S L +RE C + H I I + P+ +
Sbjct: 190 LSLAPDT------RLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFAT 243
Query: 578 GCSDGSVYVW------QMDTGALDRCVMGITAV 604
G D + ++ ++ T + D + GIT+V
Sbjct: 244 GSDDATCRLFDLRADQELMTYSHDNIICGITSV 276
Score = 39.3 bits (90), Expect = 0.029
Identities = 20/45 (44%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 1371 GARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSN 1414
GA S L+D+R G C QT GH+ I A+ F P+G AT S+
Sbjct: 202 GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSD 246
Score = 35.8 bits (81), Expect = 0.32
Identities = 24/72 (33%), Positives = 29/72 (40%), Gaps = 6/72 (8%)
Query: 30 DGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESG 89
D IVT D LWD+ Q GHT + LS A D + VS +
Sbjct: 153 DDNQIVTSSGDTTCALWDIETGQQTTT---FTGHTGDVMSLSLA---PDTRLFVSGACDA 206
Query: 90 EMCLWDVSDGRC 101
LWDV +G C
Sbjct: 207 SAKLWDVREGMC 218
Score = 33.5 bits (75), Expect = 1.6
Identities = 29/139 (20%), Positives = 56/139 (40%), Gaps = 17/139 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTLRGH K+ + + D R L+S D +IIWD ++ H + +
Sbjct: 49 RTLRGHLAKIYAMHWGT------DSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMT 102
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASR----HLFPIQVIKWRPSDD 573
P + + D+ + +L+ ++ + SR H + ++ D+
Sbjct: 103 CAYAPSG------NYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDN 155
Query: 574 YLVVGCSDGSVYVWQMDTG 592
+V D + +W ++TG
Sbjct: 156 QIVTSSGDTTCALWDIETG 174
Score = 31.6 bits (70), Expect = 6.0
Identities = 18/65 (27%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Query: 1365 NHRIAVGARHGSVALYDIRTGK-CQTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQ 1423
+++I + + AL+DI TG+ T GH G + +++ APD R L D+ W
Sbjct: 154 DNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR-LFVSGACDASAKLWD 212
Query: 1424 MNTSL 1428
+ +
Sbjct: 213 VREGM 217
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 20/125 (16%)
Query: 484 YLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT----QLLVPPENCSARVQHCICSVASD 539
Y++S GVD + IIWD +GE K F H Q + +CS + +C + D
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 540 HSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDG-SVYVWQMDTGALDRCV 598
H V H + IKW PS L+ CSD ++ +W M D CV
Sbjct: 350 HPVKTF-----------QGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---DACV 394
Query: 599 MGITA 603
+ A
Sbjct: 395 HDLQA 399
Score = 46.6 bits (109), Expect = 2e-04
Identities = 36/157 (22%), Positives = 60/157 (38%), Gaps = 10/157 (6%)
Query: 448 HMLRRGWP-PHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKH 506
H+ R G P +T +GH N+V + + L S D ++ IW + H
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPS------GMLLASCSDDMTLKIWSMKQDACVH 395
Query: 507 IFCVHGGEITQLL---VPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPI 563
H EI + P + + S + D +V L + + C +H P+
Sbjct: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 564 QVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
+ + P YL G D V++W +G+L G
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG 492
Score = 43.5 bits (101), Expect = 0.002
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
+A + +V L+D+ G C T+ H+ P+ +VAF+PDG+YLA+ + D ++ W +
Sbjct: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS-GSFDKYVHIWNTQS 483
Query: 1427 SLL 1429
L
Sbjct: 484 GSL 486
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 20/125 (16%)
Query: 484 YLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT----QLLVPPENCSARVQHCICSVASD 539
Y++S GVD + IIWD +GE K F H Q + +CS + +C + D
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 540 HSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDG-SVYVWQMDTGALDRCV 598
H V H + IKW PS L+ CSD ++ +W M D CV
Sbjct: 350 HPVKTF-----------QGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---DACV 394
Query: 599 MGITA 603
+ A
Sbjct: 395 HDLQA 399
Score = 46.6 bits (109), Expect = 2e-04
Identities = 36/157 (22%), Positives = 60/157 (38%), Gaps = 10/157 (6%)
Query: 448 HMLRRGWP-PHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKH 506
H+ R G P +T +GH N+V + + L S D ++ IW + H
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPS------GMLLASCSDDMTLKIWSMKQDACVH 395
Query: 507 IFCVHGGEITQLL---VPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPI 563
H EI + P + + S + D +V L + + C +H P+
Sbjct: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 564 QVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
+ + P YL G D V++W +G+L G
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG 492
Score = 43.5 bits (101), Expect = 0.002
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
+A + +V L+D+ G C T+ H+ P+ +VAF+PDG+YLA+ + D ++ W +
Sbjct: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS-GSFDKYVHIWNTQS 483
Query: 1427 SLL 1429
L
Sbjct: 484 GSL 486
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 47.0 bits (110), Expect = 1e-04
Identities = 37/125 (29%), Positives = 52/125 (41%), Gaps = 20/125 (16%)
Query: 484 YLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT----QLLVPPENCSARVQHCICSVASD 539
Y++S GVD + IIWD +GE K F H Q + +CS + +C + D
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCD 349
Query: 540 HSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDG-SVYVWQMDTGALDRCV 598
H V H + IKW PS L+ CSD ++ +W M D CV
Sbjct: 350 HPVKTF-----------QGHTNEVNAIKWDPS-GMLLASCSDDMTLKIWSMKQ---DACV 394
Query: 599 MGITA 603
+ A
Sbjct: 395 HDLQA 399
Score = 46.6 bits (109), Expect = 2e-04
Identities = 36/157 (22%), Positives = 60/157 (38%), Gaps = 10/157 (6%)
Query: 448 HMLRRGWP-PHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKH 506
H+ R G P +T +GH N+V + + L S D ++ IW + H
Sbjct: 342 HVCRLGCDHPVKTFQGHTNEVNAIKWDPS------GMLLASCSDDMTLKIWSMKQDACVH 395
Query: 507 IFCVHGGEITQLL---VPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPI 563
H EI + P + + S + D +V L + + C +H P+
Sbjct: 396 DLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPV 455
Query: 564 QVIKWRPSDDYLVVGCSDGSVYVWQMDTGALDRCVMG 600
+ + P YL G D V++W +G+L G
Sbjct: 456 YSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG 492
Score = 43.5 bits (101), Expect = 0.002
Identities = 21/63 (33%), Positives = 37/63 (58%), Gaps = 2/63 (3%)
Query: 1368 IAVGARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQMNT 1426
+A + +V L+D+ G C T+ H+ P+ +VAF+PDG+YLA+ + D ++ W +
Sbjct: 425 LASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLAS-GSFDKYVHIWNTQS 483
Query: 1427 SLL 1429
L
Sbjct: 484 GSL 486
>gi|55769546 PAK1 interacting protein 1 [Homo sapiens]
Length = 392
Score = 47.0 bits (110), Expect = 1e-04
Identities = 38/160 (23%), Positives = 66/160 (41%), Gaps = 15/160 (9%)
Query: 457 HRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT 516
H L H +TCL + Y R+LISG D + IWD E H G++T
Sbjct: 75 HGALVHHSGTITCLKF-------YGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVT 127
Query: 517 QLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLV 576
L + P A SV +D ++ +L E + + + +++W P + V
Sbjct: 128 FLSIHPSGKLA------LSVGTDKTLRTWNLVEGRSAFIKNIKQ-NAHIVEWSPRGEQYV 180
Query: 577 VGCSDGSVYVWQMDTGALDRCVMGITAVEILNACDEAVPA 616
V + ++Q+DT ++ + + + E+V A
Sbjct: 181 V-IIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLA 219
Score = 42.0 bits (97), Expect = 0.004
Identities = 25/90 (27%), Positives = 46/90 (51%), Gaps = 9/90 (10%)
Query: 17 APTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACAS 76
A T +SAV + + +VTG D I ++D+ +++ L H+ +ITCL
Sbjct: 40 AHTASLSAVAV--NSRFVVTGSKDETIHIYDMKKKIE---HGALVHHSGTITCLK----F 90
Query: 77 SDKQYIVSASESGEMCLWDVSDGRCIEFTK 106
++++S +E G +C+WD C++ K
Sbjct: 91 YGNRHLISGAEDGLICIWDAKKWECLKSIK 120
Score = 40.4 bits (93), Expect = 0.013
Identities = 27/103 (26%), Positives = 47/103 (45%), Gaps = 12/103 (11%)
Query: 1323 DLLVEVMDIIMYCLEGSLVKKKGLQECFPAICRFYMVSYYERNHRIAVGARHGSVALYDI 1382
D + + D+ G+LV G C + +Y H I+ GA G + ++D
Sbjct: 61 DETIHIYDMKKKIEHGALVHHSGTITC---------LKFYGNRHLIS-GAEDGLICIWDA 110
Query: 1383 RTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDSHISFWQM 1424
+ +C ++I HKG +T ++ P G+ LA TD + W +
Sbjct: 111 KKWECLKSIKAHKGQVTFLSIHPSGK-LALSVGTDKTLRTWNL 152
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/151 (21%), Positives = 70/151 (46%), Gaps = 26/151 (17%)
Query: 454 WPPH-----RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508
W P TL+GH N+V S ++D +++SG +D S+ +WD+ +G H
Sbjct: 408 WDPETETCLHTLQGHTNRV--------YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 459
Query: 509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIML---ASRHLFPIQV 565
H +T + +N + S +D +V + ++ +C+ ++H +
Sbjct: 460 TGH-QSLTSGMELKDN-------ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 511
Query: 566 IKWRPSDDYLVVGCSDGSVYVWQMDTGALDR 596
+++ + ++++ DG+V +W + TG R
Sbjct: 512 LQF--NKNFVITSSDDGTVKLWDLKTGEFIR 540
Score = 42.0 bits (97), Expect = 0.004
Identities = 34/151 (22%), Positives = 63/151 (41%), Gaps = 21/151 (13%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GH + V C+ ++ ++SG D ++ +WDI +G+ H+ H
Sbjct: 338 TLYGHTSTVRCM--------HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH------- 382
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
V C + S A D V + + C+ H + +++ ++V G
Sbjct: 383 -VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG 439
Query: 579 CSDGSVYVWQMDTGALDRCVMGITAVEILNA 609
D S+ VW ++TG C+ +T + L +
Sbjct: 440 SLDTSIRVWDVETG---NCIHTLTGHQSLTS 467
Score = 41.6 bits (96), Expect = 0.006
Identities = 43/180 (23%), Positives = 74/180 (41%), Gaps = 27/180 (15%)
Query: 11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCL 70
VL G A C+ DG +V+G +D + +WD E ++ L GHT + L
Sbjct: 378 VLMGHVAAVRCVQY-----DGRRVVSGAYDFMVKVWDPETETCLHT---LQGHTNRVYSL 429
Query: 71 SKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRLL 130
D ++VS S + +WDV G CI HT + G + + +L
Sbjct: 430 Q-----FDGIHVVSGSLDTSIRVWDVETGNCI--------HTLTGHQSLTSGMELKDNIL 476
Query: 131 CHGHYPE-ILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVW 189
G+ + + D + + L +L P+ S + + ++ V+ S G +K+W
Sbjct: 477 VSGNADSTVKIWDIKTGQCLQTLQ---GPN--KHQSAVTCLQFNKNFVITSSDDGTVKLW 531
Score = 40.0 bits (92), Expect = 0.017
Identities = 34/141 (24%), Positives = 58/141 (41%), Gaps = 18/141 (12%)
Query: 460 LRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLL 519
L GH V C+ +YD R ++SG DF V +WD + H H + L
Sbjct: 379 LMGHVAAVRCV--------QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 430
Query: 520 VPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
+ + S + D S+ + + CI + H ++ + D+ LV G
Sbjct: 431 FDGIH--------VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGN 480
Query: 580 SDGSVYVWQMDTGALDRCVMG 600
+D +V +W + TG + + G
Sbjct: 481 ADSTVKIWDIKTGQCLQTLQG 501
Score = 35.0 bits (79), Expect = 0.54
Identities = 17/69 (24%), Positives = 36/69 (52%), Gaps = 8/69 (11%)
Query: 34 IVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCL 93
I++G D + +W+ I+ L+GHT+++ C+ ++ +VS S + +
Sbjct: 316 IISGSTDRTLKVWNAETGECIHT---LYGHTSTVRCMHL-----HEKRVVSGSRDATLRV 367
Query: 94 WDVSDGRCI 102
WD+ G+C+
Sbjct: 368 WDIETGQCL 376
Score = 33.5 bits (75), Expect = 1.6
Identities = 30/145 (20%), Positives = 58/145 (40%), Gaps = 18/145 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL GH V S++ +ISG D ++ +W+ +GE H H +
Sbjct: 297 RTLVGHTGGVW--------SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV-- 346
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
C + + S + D ++ + + +C+ + H+ ++ +++ +V
Sbjct: 347 ------RCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 398
Query: 578 GCSDGSVYVWQMDTGALDRCVMGIT 602
G D V VW +T + G T
Sbjct: 399 GAYDFMVKVWDPETETCLHTLQGHT 423
Score = 31.6 bits (70), Expect = 6.0
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 7/67 (10%)
Query: 1364 RNHRIAVGARHGSVALYDIRTGKC-QTIHG---HKGPITAVAFAPDGRYLATYSNTDSHI 1419
+++ + G +V ++DI+TG+C QT+ G H+ +T + F + S+ D +
Sbjct: 472 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF---NKNFVITSSDDGTV 528
Query: 1420 SFWQMNT 1426
W + T
Sbjct: 529 KLWDLKT 535
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/151 (21%), Positives = 70/151 (46%), Gaps = 26/151 (17%)
Query: 454 WPPH-----RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508
W P TL+GH N+V S ++D +++SG +D S+ +WD+ +G H
Sbjct: 526 WDPETETCLHTLQGHTNRV--------YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 577
Query: 509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIML---ASRHLFPIQV 565
H +T + +N + S +D +V + ++ +C+ ++H +
Sbjct: 578 TGH-QSLTSGMELKDN-------ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 629
Query: 566 IKWRPSDDYLVVGCSDGSVYVWQMDTGALDR 596
+++ + ++++ DG+V +W + TG R
Sbjct: 630 LQF--NKNFVITSSDDGTVKLWDLKTGEFIR 658
Score = 42.0 bits (97), Expect = 0.004
Identities = 34/151 (22%), Positives = 63/151 (41%), Gaps = 21/151 (13%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GH + V C+ ++ ++SG D ++ +WDI +G+ H+ H
Sbjct: 456 TLYGHTSTVRCM--------HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH------- 500
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
V C + S A D V + + C+ H + +++ ++V G
Sbjct: 501 -VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG 557
Query: 579 CSDGSVYVWQMDTGALDRCVMGITAVEILNA 609
D S+ VW ++TG C+ +T + L +
Sbjct: 558 SLDTSIRVWDVETG---NCIHTLTGHQSLTS 585
Score = 41.6 bits (96), Expect = 0.006
Identities = 43/180 (23%), Positives = 74/180 (41%), Gaps = 27/180 (15%)
Query: 11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCL 70
VL G A C+ DG +V+G +D + +WD E ++ L GHT + L
Sbjct: 496 VLMGHVAAVRCVQY-----DGRRVVSGAYDFMVKVWDPETETCLHT---LQGHTNRVYSL 547
Query: 71 SKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRLL 130
D ++VS S + +WDV G CI HT + G + + +L
Sbjct: 548 Q-----FDGIHVVSGSLDTSIRVWDVETGNCI--------HTLTGHQSLTSGMELKDNIL 594
Query: 131 CHGHYPE-ILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVW 189
G+ + + D + + L +L P+ S + + ++ V+ S G +K+W
Sbjct: 595 VSGNADSTVKIWDIKTGQCLQTLQ---GPN--KHQSAVTCLQFNKNFVITSSDDGTVKLW 649
Score = 40.0 bits (92), Expect = 0.017
Identities = 34/141 (24%), Positives = 58/141 (41%), Gaps = 18/141 (12%)
Query: 460 LRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLL 519
L GH V C+ +YD R ++SG DF V +WD + H H + L
Sbjct: 497 LMGHVAAVRCV--------QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 548
Query: 520 VPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
+ + S + D S+ + + CI + H ++ + D+ LV G
Sbjct: 549 FDGIH--------VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGN 598
Query: 580 SDGSVYVWQMDTGALDRCVMG 600
+D +V +W + TG + + G
Sbjct: 599 ADSTVKIWDIKTGQCLQTLQG 619
Score = 35.0 bits (79), Expect = 0.54
Identities = 17/69 (24%), Positives = 36/69 (52%), Gaps = 8/69 (11%)
Query: 34 IVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCL 93
I++G D + +W+ I+ L+GHT+++ C+ ++ +VS S + +
Sbjct: 434 IISGSTDRTLKVWNAETGECIHT---LYGHTSTVRCMHL-----HEKRVVSGSRDATLRV 485
Query: 94 WDVSDGRCI 102
WD+ G+C+
Sbjct: 486 WDIETGQCL 494
Score = 33.5 bits (75), Expect = 1.6
Identities = 30/145 (20%), Positives = 58/145 (40%), Gaps = 18/145 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL GH V S++ +ISG D ++ +W+ +GE H H +
Sbjct: 415 RTLVGHTGGVW--------SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV-- 464
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
C + + S + D ++ + + +C+ + H+ ++ +++ +V
Sbjct: 465 ------RCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 516
Query: 578 GCSDGSVYVWQMDTGALDRCVMGIT 602
G D V VW +T + G T
Sbjct: 517 GAYDFMVKVWDPETETCLHTLQGHT 541
Score = 31.6 bits (70), Expect = 6.0
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 7/67 (10%)
Query: 1364 RNHRIAVGARHGSVALYDIRTGKC-QTIHG---HKGPITAVAFAPDGRYLATYSNTDSHI 1419
+++ + G +V ++DI+TG+C QT+ G H+ +T + F + S+ D +
Sbjct: 590 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF---NKNFVITSSDDGTV 646
Query: 1420 SFWQMNT 1426
W + T
Sbjct: 647 KLWDLKT 653
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 46.2 bits (108), Expect = 2e-04
Identities = 33/151 (21%), Positives = 70/151 (46%), Gaps = 26/151 (17%)
Query: 454 WPPH-----RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIF 508
W P TL+GH N+V S ++D +++SG +D S+ +WD+ +G H
Sbjct: 446 WDPETETCLHTLQGHTNRV--------YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTL 497
Query: 509 CVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIML---ASRHLFPIQV 565
H +T + +N + S +D +V + ++ +C+ ++H +
Sbjct: 498 TGH-QSLTSGMELKDN-------ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTC 549
Query: 566 IKWRPSDDYLVVGCSDGSVYVWQMDTGALDR 596
+++ + ++++ DG+V +W + TG R
Sbjct: 550 LQF--NKNFVITSSDDGTVKLWDLKTGEFIR 578
Score = 42.0 bits (97), Expect = 0.004
Identities = 34/151 (22%), Positives = 63/151 (41%), Gaps = 21/151 (13%)
Query: 459 TLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQL 518
TL GH + V C+ ++ ++SG D ++ +WDI +G+ H+ H
Sbjct: 376 TLYGHTSTVRCM--------HLHEKRVVSGSRDATLRVWDIETGQCLHVLMGH------- 420
Query: 519 LVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVG 578
V C + S A D V + + C+ H + +++ ++V G
Sbjct: 421 -VAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG 477
Query: 579 CSDGSVYVWQMDTGALDRCVMGITAVEILNA 609
D S+ VW ++TG C+ +T + L +
Sbjct: 478 SLDTSIRVWDVETG---NCIHTLTGHQSLTS 505
Score = 41.6 bits (96), Expect = 0.006
Identities = 43/180 (23%), Positives = 74/180 (41%), Gaps = 27/180 (15%)
Query: 11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCL 70
VL G A C+ DG +V+G +D + +WD E ++ L GHT + L
Sbjct: 416 VLMGHVAAVRCVQY-----DGRRVVSGAYDFMVKVWDPETETCLHT---LQGHTNRVYSL 467
Query: 71 SKACASSDKQYIVSASESGEMCLWDVSDGRCIEFTKLACTHTGIQFYQFSVGNQREGRLL 130
D ++VS S + +WDV G CI HT + G + + +L
Sbjct: 468 Q-----FDGIHVVSGSLDTSIRVWDVETGNCI--------HTLTGHQSLTSGMELKDNIL 514
Query: 131 CHGHYPE-ILVVDATSLEVLYSLVSKISPDWISSMSIIRSHRTQEDTVVALSVTGILKVW 189
G+ + + D + + L +L P+ S + + ++ V+ S G +K+W
Sbjct: 515 VSGNADSTVKIWDIKTGQCLQTLQ---GPN--KHQSAVTCLQFNKNFVITSSDDGTVKLW 569
Score = 40.0 bits (92), Expect = 0.017
Identities = 34/141 (24%), Positives = 58/141 (41%), Gaps = 18/141 (12%)
Query: 460 LRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLL 519
L GH V C+ +YD R ++SG DF V +WD + H H + L
Sbjct: 417 LMGHVAAVRCV--------QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQ 468
Query: 520 VPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGC 579
+ + S + D S+ + + CI + H ++ + D+ LV G
Sbjct: 469 FDGIH--------VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGN 518
Query: 580 SDGSVYVWQMDTGALDRCVMG 600
+D +V +W + TG + + G
Sbjct: 519 ADSTVKIWDIKTGQCLQTLQG 539
Score = 35.0 bits (79), Expect = 0.54
Identities = 17/69 (24%), Positives = 36/69 (52%), Gaps = 8/69 (11%)
Query: 34 IVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCL 93
I++G D + +W+ I+ L+GHT+++ C+ ++ +VS S + +
Sbjct: 354 IISGSTDRTLKVWNAETGECIHT---LYGHTSTVRCMHL-----HEKRVVSGSRDATLRV 405
Query: 94 WDVSDGRCI 102
WD+ G+C+
Sbjct: 406 WDIETGQCL 414
Score = 33.5 bits (75), Expect = 1.6
Identities = 30/145 (20%), Positives = 58/145 (40%), Gaps = 18/145 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL GH V S++ +ISG D ++ +W+ +GE H H +
Sbjct: 335 RTLVGHTGGVW--------SSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTV-- 384
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
C + + S + D ++ + + +C+ + H+ ++ +++ +V
Sbjct: 385 ------RCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVS 436
Query: 578 GCSDGSVYVWQMDTGALDRCVMGIT 602
G D V VW +T + G T
Sbjct: 437 GAYDFMVKVWDPETETCLHTLQGHT 461
Score = 31.6 bits (70), Expect = 6.0
Identities = 17/67 (25%), Positives = 34/67 (50%), Gaps = 7/67 (10%)
Query: 1364 RNHRIAVGARHGSVALYDIRTGKC-QTIHG---HKGPITAVAFAPDGRYLATYSNTDSHI 1419
+++ + G +V ++DI+TG+C QT+ G H+ +T + F + S+ D +
Sbjct: 510 KDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF---NKNFVITSSDDGTV 566
Query: 1420 SFWQMNT 1426
W + T
Sbjct: 567 KLWDLKT 573
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 46.2 bits (108), Expect = 2e-04
Identities = 32/132 (24%), Positives = 55/132 (41%), Gaps = 13/132 (9%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
R L H ++C + D +++ D + +WDI +G+ K +F H G+
Sbjct: 137 RELSAHTGYLSCCRF-------LDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMS 189
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVV 577
L V P+ + S A D S L +RE C + H I I + P+ + +
Sbjct: 190 LAVSPD------FNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICT 243
Query: 578 GCSDGSVYVWQM 589
G D S ++ +
Sbjct: 244 GSDDASCRLFDL 255
Score = 38.9 bits (89), Expect = 0.037
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 1371 GARHGSVALYDIRTGKC-QTIHGHKGPITAVAFAPDGRYLATYSNTDS 1417
GA S L+D+R G C QT GH+ I A+ F P+G + T S+ S
Sbjct: 202 GACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDAS 249
Score = 37.4 bits (85), Expect = 0.11
Identities = 28/85 (32%), Positives = 36/85 (42%), Gaps = 7/85 (8%)
Query: 17 APTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACAS 76
A T +S DD IVT D LWD+ Q + + GHT C+S A S
Sbjct: 141 AHTGYLSCCRFLDDN-NIVTSSGDTTCALWDIETGQQ---KTVFVGHTGD--CMSLA-VS 193
Query: 77 SDKQYIVSASESGEMCLWDVSDGRC 101
D +S + LWDV +G C
Sbjct: 194 PDFNLFISGACDASAKLWDVREGTC 218
Score = 33.5 bits (75), Expect = 1.6
Identities = 29/149 (19%), Positives = 59/149 (39%), Gaps = 17/149 (11%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTLRGH K+ + + D + L+S D +I+WD ++ H + +
Sbjct: 49 RTLRGHLAKIYAMHWAT------DSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMT 102
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASR----HLFPIQVIKWRPSDD 573
P + + D+ + +L+ ++ + SR H + ++ D+
Sbjct: 103 CAYAPSG------NFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFL-DDN 155
Query: 574 YLVVGCSDGSVYVWQMDTGALDRCVMGIT 602
+V D + +W ++TG +G T
Sbjct: 156 NIVTSSGDTTCALWDIETGQQKTVFVGHT 184
Score = 31.6 bits (70), Expect = 6.0
Identities = 16/44 (36%), Positives = 26/44 (59%), Gaps = 3/44 (6%)
Query: 52 LQINPRALLFGHTASITCLSKACASSDKQYIVSASESGEMCLWD 95
+Q+ R L GH A I + A +D + +VSAS+ G++ +WD
Sbjct: 43 VQMRTRRTLRGHLAKIYAMHWA---TDSKLLVSASQDGKLIVWD 83
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 46.2 bits (108), Expect = 2e-04
Identities = 34/143 (23%), Positives = 60/143 (41%), Gaps = 18/143 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL+GH NKV C+ + D+R ++S D VI+WD F+ +H + +
Sbjct: 57 RTLKGHGNKVLCMDWCK------DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMA 110
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASR------HLFPIQVIKWRPS 571
P C+ I D+ + L K +A++ H + + S
Sbjct: 111 CAYAPSGCA------IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 164
Query: 572 DDYLVVGCSDGSVYVWQMDTGAL 594
D ++ DG+ +W +++G L
Sbjct: 165 DMQILTASGDGTCALWDVESGQL 187
Score = 44.7 bits (104), Expect = 7e-04
Identities = 37/181 (20%), Positives = 73/181 (40%), Gaps = 20/181 (11%)
Query: 409 VTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVT 468
V A Y P+ + CG D + P T + E+M + +++ H N ++
Sbjct: 108 VMACAYAPSGCAIACGGLDNKCSVYPLTFD------KNENMAAK----KKSVAMHTNYLS 157
Query: 469 CLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSAR 528
+ + D + L + G D + +WD+ SG++ F HG ++ L + P +
Sbjct: 158 ACSFTNS-----DMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAP----SE 207
Query: 529 VQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQ 588
+ S D + +R +C+ H I +++ PS D G D + ++
Sbjct: 208 TGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
Query: 589 M 589
+
Sbjct: 268 L 268
Score = 41.2 bits (95), Expect = 0.008
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 19 THCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSD 78
T+ +SA T+ I+T DG LWD+ + GH A + CL A + +
Sbjct: 153 TNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQS---FHGHGADVLCLDLAPSETG 209
Query: 79 KQYIVSASESGEMCLWDVSDGRCIE 103
++ + M +WD+ G+C++
Sbjct: 210 NTFVSGGCDKKAM-VWDMRSGQCVQ 233
Score = 41.2 bits (95), Expect = 0.008
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 458 RTLRGHRNKVTCL-LYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT 516
++ GH V CL L P + + +SGG D ++WD+ SG+ F H +I
Sbjct: 189 QSFHGHGADVLCLDLAPSETGNTF-----VSGGCDKKAMVWDMRSGQCVQAFETHESDIN 243
Query: 517 QLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRH--LFPIQVIKWRPSDDY 574
+ P S + D + L LR + + + S+ +F + + S
Sbjct: 244 SVRYYPSG------DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRL 297
Query: 575 LVVGCSDGSVYVWQMDTGA 593
L G +D ++ VW + G+
Sbjct: 298 LFAGYNDYTINVWDVLKGS 316
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 46.2 bits (108), Expect = 2e-04
Identities = 34/143 (23%), Positives = 60/143 (41%), Gaps = 18/143 (12%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
RTL+GH NKV C+ + D+R ++S D VI+WD F+ +H + +
Sbjct: 99 RTLKGHGNKVLCMDWCK------DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMA 152
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASR------HLFPIQVIKWRPS 571
P C+ I D+ + L K +A++ H + + S
Sbjct: 153 CAYAPSGCA------IACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNS 206
Query: 572 DDYLVVGCSDGSVYVWQMDTGAL 594
D ++ DG+ +W +++G L
Sbjct: 207 DMQILTASGDGTCALWDVESGQL 229
Score = 44.7 bits (104), Expect = 7e-04
Identities = 37/181 (20%), Positives = 73/181 (40%), Gaps = 20/181 (11%)
Query: 409 VTASVYIPAHGRLVCGREDGSIVIVPATQTAIVQLLQGEHMLRRGWPPHRTLRGHRNKVT 468
V A Y P+ + CG D + P T + E+M + +++ H N ++
Sbjct: 150 VMACAYAPSGCAIACGGLDNKCSVYPLTFD------KNENMAAK----KKSVAMHTNYLS 199
Query: 469 CLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQLLVPPENCSAR 528
+ + D + L + G D + +WD+ SG++ F HG ++ L + P +
Sbjct: 200 ACSFTNS-----DMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAP----SE 249
Query: 529 VQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQVIKWRPSDDYLVVGCSDGSVYVWQ 588
+ S D + +R +C+ H I +++ PS D G D + ++
Sbjct: 250 TGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 309
Query: 589 M 589
+
Sbjct: 310 L 310
Score = 41.2 bits (95), Expect = 0.008
Identities = 22/85 (25%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 19 THCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSD 78
T+ +SA T+ I+T DG LWD+ + GH A + CL A + +
Sbjct: 195 TNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQS---FHGHGADVLCLDLAPSETG 251
Query: 79 KQYIVSASESGEMCLWDVSDGRCIE 103
++ + M +WD+ G+C++
Sbjct: 252 NTFVSGGCDKKAM-VWDMRSGQCVQ 275
Score = 41.2 bits (95), Expect = 0.008
Identities = 33/139 (23%), Positives = 58/139 (41%), Gaps = 14/139 (10%)
Query: 458 RTLRGHRNKVTCL-LYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEIT 516
++ GH V CL L P + + +SGG D ++WD+ SG+ F H +I
Sbjct: 231 QSFHGHGADVLCLDLAPSETGNTF-----VSGGCDKKAMVWDMRSGQCVQAFETHESDIN 285
Query: 517 QLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRH--LFPIQVIKWRPSDDY 574
+ P S + D + L LR + + + S+ +F + + S
Sbjct: 286 SVRYYPSG------DAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRL 339
Query: 575 LVVGCSDGSVYVWQMDTGA 593
L G +D ++ VW + G+
Sbjct: 340 LFAGYNDYTINVWDVLKGS 358
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 45.4 bits (106), Expect = 4e-04
Identities = 36/146 (24%), Positives = 59/146 (40%), Gaps = 21/146 (14%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
R L GH V CL +YD+R +I+G D +V +WD+ +GEM + H +
Sbjct: 301 RILTGHTGSVLCL--------QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLAS---RHLFPIQVIKWRPSDDY 574
L + + + D S+ + + I L H + V+ + D Y
Sbjct: 353 LRFN--------NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKY 402
Query: 575 LVVGCSDGSVYVWQMDTGALDRCVMG 600
+V D ++ VW T R + G
Sbjct: 403 IVSASGDRTIKVWNTSTCEFVRTLNG 428
Score = 42.4 bits (98), Expect = 0.003
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 20 HCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDK 79
HC + + L + +VT D I +WD++ I R +L GH A++ + D
Sbjct: 346 HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV-----DFDD 400
Query: 80 QYIVSASESGEMCLWDVS 97
+YIVSAS + +W+ S
Sbjct: 401 KYIVSASGDRTIKVWNTS 418
Score = 41.6 bits (96), Expect = 0.006
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 30 DGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESG 89
D IV+G D I +WD + + + +L GHT S+ CL D++ I++ S
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNT---LECKRILTGHTGSVLCL-----QYDERVIITGSSDS 327
Query: 90 EMCLWDVSDGRCI 102
+ +WDV+ G +
Sbjct: 328 TVRVWDVNTGEML 340
Score = 35.4 bits (80), Expect = 0.41
Identities = 43/177 (24%), Positives = 79/177 (44%), Gaps = 28/177 (15%)
Query: 446 GEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMK 505
G H L+R T +G V CL +YD + ++SG D ++ IWD + E K
Sbjct: 253 GRHSLQRIHCRSETSKG----VYCL--------QYDDQKIVSGLRDNTIKIWDKNTLECK 300
Query: 506 HIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQV 565
I H G + C + I + +SD +V + + + + H +
Sbjct: 301 RILTGHTGSVL--------CLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 352
Query: 566 IKWRPSDDYLVVGCS-DGSVYVWQMDTG---ALDRCVMG-ITAVEILNACDEAVPAA 617
+++ ++ ++V CS D S+ VW M + L R ++G AV +++ D+ + +A
Sbjct: 353 LRF---NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSA 406
Score = 35.0 bits (79), Expect = 0.54
Identities = 42/195 (21%), Positives = 73/195 (37%), Gaps = 39/195 (20%)
Query: 320 DKELLICPPVTRFFYG---CREYFHKLLIQGDSSGRLNIWNISDTADKQGSEEGLAMTTS 376
DK L C + G C +Y +++I G S + +W+++ G + T
Sbjct: 293 DKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNT---------GEMLNTL 343
Query: 377 ISLQEAFDKLNPCPAGII----DQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVI 432
I EA L ++ D+ + + P +T + H V + I
Sbjct: 344 IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYI 403
Query: 433 VPATQTAIVQLLQGEHMLRRGWPPH-----RTLRGHRNKVTCLLYPHQVSARYDQRYLIS 487
V A+ +++ W RTL GH+ + CL +Y R ++S
Sbjct: 404 VSASGDRTIKV----------WNTSTCEFVRTLNGHKRGIACL--------QYRDRLVVS 445
Query: 488 GGVDFSVIIWDIFSG 502
G D ++ +WDI G
Sbjct: 446 GSSDNTIRLWDIECG 460
Score = 34.7 bits (78), Expect = 0.71
Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 20/93 (21%)
Query: 11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCL 70
VL G + CI D IV+G +DG+I +WDL L +PRA A CL
Sbjct: 465 VLEGHEELVRCIRF-----DNKRIVSGAYDGKIKVWDLVAAL--DPRA-----PAGTLCL 512
Query: 71 SKACASS--------DKQYIVSASESGEMCLWD 95
S D+ IVS+S + +WD
Sbjct: 513 RTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD 545
Score = 31.2 bits (69), Expect = 7.8
Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 8/42 (19%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDI 499
R L GH V C+ R+D + ++SG D + +WD+
Sbjct: 464 RVLEGHEELVRCI--------RFDNKRIVSGAYDGKIKVWDL 497
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 45.4 bits (106), Expect = 4e-04
Identities = 36/146 (24%), Positives = 59/146 (40%), Gaps = 21/146 (14%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMKHIFCVHGGEITQ 517
R L GH V CL +YD+R +I+G D +V +WD+ +GEM + H +
Sbjct: 337 RILTGHTGSVLCL--------QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
Query: 518 LLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLAS---RHLFPIQVIKWRPSDDY 574
L + + + D S+ + + I L H + V+ + D Y
Sbjct: 389 LRFN--------NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKY 438
Query: 575 LVVGCSDGSVYVWQMDTGALDRCVMG 600
+V D ++ VW T R + G
Sbjct: 439 IVSASGDRTIKVWNTSTCEFVRTLNG 464
Score = 42.4 bits (98), Expect = 0.003
Identities = 24/78 (30%), Positives = 39/78 (50%), Gaps = 5/78 (6%)
Query: 20 HCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDK 79
HC + + L + +VT D I +WD++ I R +L GH A++ + D
Sbjct: 382 HCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVV-----DFDD 436
Query: 80 QYIVSASESGEMCLWDVS 97
+YIVSAS + +W+ S
Sbjct: 437 KYIVSASGDRTIKVWNTS 454
Score = 41.6 bits (96), Expect = 0.006
Identities = 22/73 (30%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 30 DGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCLSKACASSDKQYIVSASESG 89
D IV+G D I +WD + + + +L GHT S+ CL D++ I++ S
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNT---LECKRILTGHTGSVLCL-----QYDERVIITGSSDS 363
Query: 90 EMCLWDVSDGRCI 102
+ +WDV+ G +
Sbjct: 364 TVRVWDVNTGEML 376
Score = 35.4 bits (80), Expect = 0.41
Identities = 43/177 (24%), Positives = 79/177 (44%), Gaps = 28/177 (15%)
Query: 446 GEHMLRRGWPPHRTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDIFSGEMK 505
G H L+R T +G V CL +YD + ++SG D ++ IWD + E K
Sbjct: 289 GRHSLQRIHCRSETSKG----VYCL--------QYDDQKIVSGLRDNTIKIWDKNTLECK 336
Query: 506 HIFCVHGGEITQLLVPPENCSARVQHCICSVASDHSVGLLSLREKKCIMLASRHLFPIQV 565
I H G + C + I + +SD +V + + + + H +
Sbjct: 337 RILTGHTGSVL--------CLQYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLH 388
Query: 566 IKWRPSDDYLVVGCS-DGSVYVWQMDTG---ALDRCVMG-ITAVEILNACDEAVPAA 617
+++ ++ ++V CS D S+ VW M + L R ++G AV +++ D+ + +A
Sbjct: 389 LRF---NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSA 442
Score = 35.0 bits (79), Expect = 0.54
Identities = 42/195 (21%), Positives = 73/195 (37%), Gaps = 39/195 (20%)
Query: 320 DKELLICPPVTRFFYG---CREYFHKLLIQGDSSGRLNIWNISDTADKQGSEEGLAMTTS 376
DK L C + G C +Y +++I G S + +W+++ G + T
Sbjct: 329 DKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNT---------GEMLNTL 379
Query: 377 ISLQEAFDKLNPCPAGII----DQLSVIPNSNEPLKVTASVYIPAHGRLVCGREDGSIVI 432
I EA L ++ D+ + + P +T + H V + I
Sbjct: 380 IHHCEAVLHLRFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYI 439
Query: 433 VPATQTAIVQLLQGEHMLRRGWPPH-----RTLRGHRNKVTCLLYPHQVSARYDQRYLIS 487
V A+ +++ W RTL GH+ + CL +Y R ++S
Sbjct: 440 VSASGDRTIKV----------WNTSTCEFVRTLNGHKRGIACL--------QYRDRLVVS 481
Query: 488 GGVDFSVIIWDIFSG 502
G D ++ +WDI G
Sbjct: 482 GSSDNTIRLWDIECG 496
Score = 34.7 bits (78), Expect = 0.71
Identities = 30/93 (32%), Positives = 40/93 (43%), Gaps = 20/93 (21%)
Query: 11 VLWGRKAPTHCISAVLLTDDGATIVTGCHDGQICLWDLSVELQINPRALLFGHTASITCL 70
VL G + CI D IV+G +DG+I +WDL L +PRA A CL
Sbjct: 501 VLEGHEELVRCIRF-----DNKRIVSGAYDGKIKVWDLVAAL--DPRA-----PAGTLCL 548
Query: 71 SKACASS--------DKQYIVSASESGEMCLWD 95
S D+ IVS+S + +WD
Sbjct: 549 RTLVEHSGRVFRLQFDEFQIVSSSHDDTILIWD 581
Score = 31.2 bits (69), Expect = 7.8
Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 8/42 (19%)
Query: 458 RTLRGHRNKVTCLLYPHQVSARYDQRYLISGGVDFSVIIWDI 499
R L GH V C+ R+D + ++SG D + +WD+
Sbjct: 500 RVLEGHEELVRCI--------RFDNKRIVSGAYDGKIKVWDL 533
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,625,778
Number of Sequences: 37866
Number of extensions: 2653963
Number of successful extensions: 12155
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 154
Number of HSP's that attempted gapping in prelim test: 10578
Number of HSP's gapped (non-prelim): 1527
length of query: 1490
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1375
effective length of database: 13,892,928
effective search space: 19102776000
effective search space used: 19102776000
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.