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Search of human proteins with 72534676
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo
sapiens]
(441 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo sa... 923 0.0
gi|239582714 leucine rich repeat containing 17 isoform 2 [Homo s... 635 0.0
gi|188528675 slit homolog 1 [Homo sapiens] 119 7e-27
gi|4759146 slit homolog 2 [Homo sapiens] 116 4e-26
gi|11321571 slit homolog 3 [Homo sapiens] 116 4e-26
gi|51317373 netrin-G1 ligand [Homo sapiens] 98 1e-20
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 98 2e-20
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 98 2e-20
gi|40217820 slit and trk like 3 protein [Homo sapiens] 86 5e-17
gi|41350214 asporin [Homo sapiens] 85 1e-16
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 84 3e-16
gi|16418445 leucine rich repeat containing 3B [Homo sapiens] 83 4e-16
gi|194440719 chondroadherin-like [Homo sapiens] 82 1e-15
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 81 2e-15
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 81 2e-15
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 81 2e-15
gi|27436867 slit and trk like 4 protein [Homo sapiens] 80 3e-15
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 80 4e-15
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 79 8e-15
gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo... 78 2e-14
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 75 9e-14
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 75 9e-14
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 75 1e-13
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 75 2e-13
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 75 2e-13
gi|40217817 slit and trk like 1 protein [Homo sapiens] 74 3e-13
gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens] 74 3e-13
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti... 73 5e-13
gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ... 73 5e-13
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ... 73 5e-13
>gi|72534676 leucine rich repeat containing 17 isoform 1 [Homo
sapiens]
Length = 441
Score = 923 bits (2386), Expect = 0.0
Identities = 441/441 (100%), Positives = 441/441 (100%)
Query: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL
Sbjct: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
Query: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI
Sbjct: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI
Sbjct: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST
Sbjct: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
Query: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS
Sbjct: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
Query: 301 SNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHY 360
SNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHY
Sbjct: 301 SNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHY 360
Query: 361 LYYWLKHHYNVHFNGLECKTPEEYKGWSVGKYIRSYYEECPKDKLPAYPESFDQDTEDDE 420
LYYWLKHHYNVHFNGLECKTPEEYKGWSVGKYIRSYYEECPKDKLPAYPESFDQDTEDDE
Sbjct: 361 LYYWLKHHYNVHFNGLECKTPEEYKGWSVGKYIRSYYEECPKDKLPAYPESFDQDTEDDE 420
Query: 421 WEKKHRDHTAKKQSVIITIVG 441
WEKKHRDHTAKKQSVIITIVG
Sbjct: 421 WEKKHRDHTAKKQSVIITIVG 441
>gi|239582714 leucine rich repeat containing 17 isoform 2 [Homo
sapiens]
Length = 313
Score = 635 bits (1637), Expect = 0.0
Identities = 309/311 (99%), Positives = 310/311 (99%)
Query: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL
Sbjct: 1 MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRRGSNPVKRYAPGLPCDVYTYL 60
Query: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI
Sbjct: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI
Sbjct: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQI 180
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST
Sbjct: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
Query: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS
Sbjct: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLS 300
Query: 301 SNGIEFIDPAA 311
SNGIEFIDP +
Sbjct: 301 SNGIEFIDPGS 311
Score = 69.3 bits (168), Expect = 6e-12
Identities = 46/135 (34%), Positives = 66/135 (48%), Gaps = 1/135 (0%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAA 311
LDC+ ++L V P D++ + L+ NKI L+ F +LK L+L N I I+ A
Sbjct: 65 LDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEA 124
Query: 312 FLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNV 371
F GL L L L +N ++ V L L L DNPW C I L L+ N
Sbjct: 125 FFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNR 184
Query: 372 HF-NGLECKTPEEYK 385
+ N +C++P+E K
Sbjct: 185 NLGNYAKCESPQEQK 199
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 119 bits (297), Expect = 7e-27
Identities = 101/373 (27%), Positives = 162/373 (43%), Gaps = 56/373 (15%)
Query: 35 AGGGRRGSNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIR 94
+G G G P + G C +DC+ + L + P+ + + L N I+
Sbjct: 264 SGQGEAGRVPTCTLSSG-SCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIK 322
Query: 95 TLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF--IYT 152
++ FS ++KL+ +DL N+I++I +AF GL L +L+L N+I L VF +YT
Sbjct: 323 SIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYT 382
Query: 153 ----------------------PLLSYLRLYDN------------------------PWH 166
LS L LYDN P+
Sbjct: 383 LQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFI 442
Query: 167 CTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL-CNEEEKEQLDPKPQ 225
C C ++ L L+ G A+C SP+ NK++ QIKS++ C+ +E+ + P
Sbjct: 443 CDCNLKWLADFLRTNPIETSG--ARCASPRRLANKRIGQIKSKKFRCSAKEQYFI---PG 497
Query: 226 VSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRP 285
+ D H ++C +L K+P IP +L L+ N+I+ L
Sbjct: 498 TEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEA 557
Query: 286 KE-FEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKL 344
F+ + LKK+NLS+N + I+ AF G + EL L+ N L++ G+ L L+
Sbjct: 558 TGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRT 617
Query: 345 LWLRDNPWRCDYN 357
L LR+N C +N
Sbjct: 618 LMLRNNRISCIHN 630
Score = 113 bits (283), Expect = 3e-25
Identities = 83/276 (30%), Positives = 127/276 (46%), Gaps = 15/276 (5%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
Q L + L+ N I+ + F LK+L L +N+IS IE AF L L L L +N
Sbjct: 133 QALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNN 192
Query: 141 IKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKN 200
I + F + P L RL+ N C C + L L+ + +G + +C P +
Sbjct: 193 ITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLR--QRPTIGLFTQCSGPASLRG 250
Query: 201 KKLRQI-KSEQLCNEEEKEQLDPKPQVS-GRPPVIKPEVDSTFCHNYVFPIQTLDCKRKE 258
+ ++ KSE C+ + + P +S G P + C N + +DC+ K
Sbjct: 251 LNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAM------CTCSNGI-----VDCRGKG 299
Query: 259 LKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHL 318
L +P N+P + ++ L N I + P F +L++++LS+N I I P AF GL L
Sbjct: 300 LTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSL 359
Query: 319 EELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRC 354
L L N + + GV LY L+LL L N C
Sbjct: 360 NSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Score = 111 bits (277), Expect = 1e-24
Identities = 86/324 (26%), Positives = 142/324 (43%), Gaps = 43/324 (13%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
L N++ ++++ MF L++L L+ N IS I +++F GL + L L NQI ++
Sbjct: 596 LTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPG 655
Query: 148 VFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIK 207
F LS L L NP++C C++ L L+ + + + +C++P + L+ +
Sbjct: 656 AFDTLQSLSTLNLLANPFNCNCQLAWLGGWLR--KRKIVTGNPRCQNPDFLRQIPLQDVA 713
Query: 208 SEQLCNEEEKEQLD--PKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNN 265
EE +E+ P+PQ C + V + C K L+ +P
Sbjct: 714 FPDFRCEEGQEEGGCLPRPQCP----------QECACLDTV-----VRCSNKHLRALPKG 758
Query: 266 IPPDIVKL-----------------------DLSYNKINQLRPKEFEDVHELKKLNLSSN 302
IP ++ +L DLS NKI+ L F ++ +L L LS N
Sbjct: 759 IPKNVTELYLDGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYN 818
Query: 303 GIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLY 362
++ I P AF GL L L L N + G+ D+ L L + NP CD ++ +L
Sbjct: 819 ALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLS 878
Query: 363 YWLKHHYNVHFNGLECKTPEEYKG 386
W+K Y C P++ +G
Sbjct: 879 SWVKTGYK-EPGIARCAGPQDMEG 901
Score = 59.7 bits (143), Expect = 5e-09
Identities = 43/154 (27%), Positives = 70/154 (45%), Gaps = 8/154 (5%)
Query: 249 IQTLDCKRKELKKVPNNIPPD---IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
++ L R +L +P + + + +LDLS N I + K F +LK L L N I
Sbjct: 111 LERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQIS 170
Query: 306 FIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
I+ AF L LE L L+NN++ + L+ L N CD ++ +L WL
Sbjct: 171 CIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWL 230
Query: 366 KHHYNVHFNGL--ECKTPEEYKGWSVGKYIRSYY 397
+ + GL +C P +G +V + +S +
Sbjct: 231 RQRPTI---GLFTQCSGPASLRGLNVAEVQKSEF 261
Score = 52.4 bits (124), Expect = 8e-07
Identities = 30/100 (30%), Positives = 51/100 (51%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPA 310
T+DC L+ +P NIP + +L+L+ N I ++ +F + +L+ L L N I ++
Sbjct: 44 TVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERG 103
Query: 311 AFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
AF + LE L L+ N L + ++ L L L +N
Sbjct: 104 AFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSEN 143
Score = 49.7 bits (117), Expect = 5e-06
Identities = 31/99 (31%), Positives = 49/99 (49%)
Query: 65 LDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEA 124
+DC L + P++ + L N I + N F+ K+L+ L L +N+I +E A
Sbjct: 45 VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGA 104
Query: 125 FFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
F + +L L L NQ+ +L E +F LS L L +N
Sbjct: 105 FDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSEN 143
Score = 34.7 bits (78), Expect = 0.18
Identities = 22/67 (32%), Positives = 30/67 (44%)
Query: 105 KKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNP 164
+ + L+L N I++I F GL +L L L NQI + F L LRL N
Sbjct: 61 RNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQ 120
Query: 165 WHCTCEI 171
H E+
Sbjct: 121 LHMLPEL 127
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 116 bits (291), Expect = 4e-26
Identities = 93/364 (25%), Positives = 162/364 (44%), Gaps = 61/364 (16%)
Query: 52 LPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLD 111
L C +DC+ + L + P+ + + L +N I+ + FS +KKL+ +D
Sbjct: 271 LHCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRID 330
Query: 112 LQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF---------------------- 149
L N+IS++ +AF GL L +L+L N+I L + +F
Sbjct: 331 LSNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVD 390
Query: 150 ------------------------IYTPL--LSYLRLYDNPWHCTCEIETLISMLQIPRN 183
++PL + + L NP+ C C ++ L L
Sbjct: 391 AFQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPI 450
Query: 184 RNLGNYAKCESPQEQKNKKLRQIKSEQL-CNEEEKEQL----DPKPQVSGRPPVIKPEVD 238
G A+C SP+ NK++ QIKS++ C+ +E+ + D + ++SG +
Sbjct: 451 ETSG--ARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADLACPE 508
Query: 239 STFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKE-FEDVHELKKL 297
C T+DC ++L K+P +IP +L L+ N+ L F+ + +L+K+
Sbjct: 509 KCRCEG-----TTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKI 563
Query: 298 NLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYN 357
N S+N I I+ AF G + + E+ L++N L+N + + + L LK L LR N C N
Sbjct: 564 NFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGN 623
Query: 358 IHYL 361
++
Sbjct: 624 DSFI 627
Score = 113 bits (283), Expect = 3e-25
Identities = 79/273 (28%), Positives = 123/273 (45%), Gaps = 16/273 (5%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L+ N+I+ + F +K+L L N+IS IE AF L L L L +N I
Sbjct: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT 188
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISML-QIPRNRNLGNYAKCESPQEQKNK 201
L+ F + P L RL+ N +C C + L L Q PR +G Y +C P +
Sbjct: 189 RLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPR---VGLYTQCMGPSHLRGH 245
Query: 202 KLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKK 261
+ +++ + + + P V P C N + +DC+ K L +
Sbjct: 246 NVAEVQKREFVCSGHQSFMAPSCSVLHCPAACT-------CSNNI-----VDCRGKGLTE 293
Query: 262 VPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEEL 321
+P N+P I ++ L N I + P F +L++++LS+N I + P AF GL L L
Sbjct: 294 IPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSL 353
Query: 322 DLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRC 354
L N + + E L+ L+LL L N C
Sbjct: 354 VLYGNKITELPKSLFEGLFSLQLLLLNANKINC 386
Score = 106 bits (264), Expect = 5e-23
Identities = 82/307 (26%), Positives = 132/307 (42%), Gaps = 38/307 (12%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
+LL N++ +++ MF + LK+L L+ N I+ + +++F GL+ + L L NQI +
Sbjct: 587 ILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVA 646
Query: 146 EEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQ 205
F LS L L NP++C C + L L+ + R + +C+ P K ++
Sbjct: 647 PGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLR--KKRIVTGNPRCQKPYFLKEIPIQD 704
Query: 206 IKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNN 265
+ + ++ + P R P +D+ + C K LK +P
Sbjct: 705 VAIQDFTCDDGNDDNSCSPL--SRCPTECTCLDTV-----------VRCSNKGLKVLPKG 751
Query: 266 IPPDIVKL-----------------------DLSYNKINQLRPKEFEDVHELKKLNLSSN 302
IP D+ +L DLS N+I+ L + F ++ +L L LS N
Sbjct: 752 IPRDVTELYLDGNQFTLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYN 811
Query: 303 GIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLY 362
+ I P F GL L L L N + G DL L L + NP CD N+ +L
Sbjct: 812 RLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLS 871
Query: 363 YWLKHHY 369
W+K Y
Sbjct: 872 DWVKSEY 878
Score = 58.5 bits (140), Expect = 1e-08
Identities = 32/81 (39%), Positives = 44/81 (54%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPA 310
T+DC L+ VP NIP + +LDL+ N I ++ +F + L+ L L N I I+
Sbjct: 38 TVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERG 97
Query: 311 AFLGLTHLEELDLSNNSLQNF 331
AF L LE L L+ N LQ F
Sbjct: 98 AFQDLKELERLRLNRNHLQLF 118
Score = 57.8 bits (138), Expect = 2e-08
Identities = 36/122 (29%), Positives = 56/122 (45%), Gaps = 1/122 (0%)
Query: 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQ 329
+ +LDLS N+I + K F ++K L L N I I+ AF L LE L L+NN++
Sbjct: 129 LYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIT 188
Query: 330 NFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGLECKTPEEYKGWSV 389
+ L+ L N CD ++ +L WL+ V +C P +G +V
Sbjct: 189 RLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLY-TQCMGPSHLRGHNV 247
Query: 390 GK 391
+
Sbjct: 248 AE 249
Score = 31.6 bits (70), Expect = 1.5
Identities = 20/59 (33%), Positives = 26/59 (44%)
Query: 105 KKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+ + LDL N I++I F GL L L L N+I + F L LRL N
Sbjct: 55 RNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRN 113
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 116 bits (291), Expect = 4e-26
Identities = 97/368 (26%), Positives = 165/368 (44%), Gaps = 65/368 (17%)
Query: 42 SNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMF 101
S P A + C +DC+ + L+ + P+ ++ + L +N I+ + F
Sbjct: 268 SEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAF 327
Query: 102 SKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF------------ 149
+++KKLK +D+ +N+IS I +AF GL LT+L+L N+I + + +F
Sbjct: 328 TQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLN 387
Query: 150 ----------------------------------IYTPLLSY--LRLYDNPWHCTCEIET 173
++ PL S L L NP+ C C ++
Sbjct: 388 ANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKW 447
Query: 174 LISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL-CNEEEKEQLDPKPQVSGR--P 230
L LQ G A+C SP+ NK++ QIKS++ C+ E D + + S
Sbjct: 448 LADYLQDNPIETSG--ARCSSPRRLANKRISQIKSKKFRCSGSE----DYRSRFSSECFM 501
Query: 231 PVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKE-FE 289
++ PE C + +DC ++L ++P+++P + L L+ N+++ L F+
Sbjct: 502 DLVCPE--KCRCEGTI-----VDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFK 554
Query: 290 DVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRD 349
+ L+K+NLS+N I+ + AF G ++EL L+ N L+ V L LK L LR
Sbjct: 555 KLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRS 614
Query: 350 NPWRCDYN 357
N C N
Sbjct: 615 NLIGCVSN 622
Score = 109 bits (273), Expect = 4e-24
Identities = 80/276 (28%), Positives = 124/276 (44%), Gaps = 21/276 (7%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L+ N+I+ + F +K+L L N IS IE AF L L L L +N I
Sbjct: 135 LTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNIS 194
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKK 202
+ F + P + LRL+ N +C C + L L+ + R +G + C +P
Sbjct: 195 RILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLR--QRRTVGQFTLCMAPVH----- 247
Query: 203 LRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST----FCHNYVFPIQTLDCKRKE 258
++ + + ++KE + P P PP S C N + +DC+ K
Sbjct: 248 ---LRGFNVADVQKKEYVCPAPH--SEPPSCNANSISCPSPCTCSNNI-----VDCRGKG 297
Query: 259 LKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHL 318
L ++P N+P IV++ L N I + F +LK++++S N I I P AF GL L
Sbjct: 298 LMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSL 357
Query: 319 EELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRC 354
L L N + G+ + L L+LL L N C
Sbjct: 358 TSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINC 393
Score = 103 bits (257), Expect = 3e-22
Identities = 85/324 (26%), Positives = 133/324 (41%), Gaps = 48/324 (14%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
++L N++ T+ +F LK+L L+ N I + ++ F GL+ + L L N+I +T
Sbjct: 586 LMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTIT 645
Query: 146 EEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQ 205
F LS + L NP++C C + L L+ + R + +C+ P K ++
Sbjct: 646 PGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLR--KRRIVSGNPRCQKPFFLKEIPIQD 703
Query: 206 IKSEQLC---NEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTL-DCKRKELKK 261
+ + NEE QL P+ C ++T+ C K L+
Sbjct: 704 VAIQDFTCDGNEESSCQLSPR------------------CPEQCTCMETVVRCSNKGLRA 745
Query: 262 VPNNIPPDIVKL-----------------------DLSYNKINQLRPKEFEDVHELKKLN 298
+P +P D+ +L DLS N I+ L F ++ L L
Sbjct: 746 LPRGMPKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLI 805
Query: 299 LSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNI 358
LS N + I AF GL L L L N + + G DL L L L NP CD ++
Sbjct: 806 LSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSL 865
Query: 359 HYLYYWLKHHYNVHFNGLECKTPE 382
+L W+K Y C +PE
Sbjct: 866 RWLSEWVKAGYK-EPGIARCSSPE 888
Score = 63.2 bits (152), Expect = 5e-10
Identities = 44/156 (28%), Positives = 74/156 (47%), Gaps = 5/156 (3%)
Query: 249 IQTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
++ L + +L+ +P + P + +LDLS N+I + K F + ++K L L +N I
Sbjct: 111 LERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHIS 170
Query: 306 FIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
I+ AF L LE L L+NN++ + ++ L L N CD ++ +L WL
Sbjct: 171 CIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWL 230
Query: 366 KHHYNVHFNGLECKTPEEYKGWSVGKYIRSYYEECP 401
+ V L C P +G++V + Y CP
Sbjct: 231 RQRRTVGQFTL-CMAPVHLRGFNVADVQKKEY-VCP 264
Score = 54.3 bits (129), Expect = 2e-07
Identities = 32/91 (35%), Positives = 47/91 (51%), Gaps = 5/91 (5%)
Query: 251 TLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPA 310
++DC L+ VP IP + +LDL N I ++ +F + L+ L+L N + I+
Sbjct: 44 SVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERG 103
Query: 311 AFLGLTHLEELDLSNNSLQNFDYGVLEDLYF 341
AF L LE L L+ N LQ VL +L F
Sbjct: 104 AFQDLKQLERLRLNKNKLQ-----VLPELLF 129
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 98.2 bits (243), Expect = 1e-20
Identities = 89/335 (26%), Positives = 148/335 (44%), Gaps = 51/335 (15%)
Query: 67 CQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF 126
C + L V G + + L N+I+ +K N F + L+ L L +N I IE AF
Sbjct: 62 CVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFN 121
Query: 127 GLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISML--QIPRNR 184
GL L TL L N++ + F+Y L L L +NP IE++ S +IP R
Sbjct: 122 GLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNP------IESIPSYAFNRIPSLR 175
Query: 185 NLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHN 244
L L ++K +E E L
Sbjct: 176 RLD---------------LGELKRLSYISEGAFEGLSN---------------------- 198
Query: 245 YVFPIQTLDCKRKELKKVPNNIPP-DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNG 303
++ L+ L+++PN P + +LDLS N ++ +RP F+ + L+KL + +
Sbjct: 199 ----LRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQ 254
Query: 304 IEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYY 363
I+ I+ AF L L E++L++N+L + + L+ L+ + L NPW C+ +I +L +
Sbjct: 255 IQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSW 314
Query: 364 WLKHHYNVHFN-GLECKTPEEYKGWSVGKYIRSYY 397
W+K + C TP KG +G+ ++Y+
Sbjct: 315 WIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYF 349
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 97.8 bits (242), Expect = 2e-20
Identities = 85/303 (28%), Positives = 135/303 (44%), Gaps = 46/303 (15%)
Query: 67 CQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF 126
C R L V G P + ++ L N I+ ++ + F L+ L L +N I +IE AF
Sbjct: 61 CTRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFN 120
Query: 127 GLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNL 186
GL L TL L N + V+ F Y L L L +NP IE++ S
Sbjct: 121 GLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNP------IESIPS---------- 164
Query: 187 GNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYV 246
YA P + L ++K + +E E L
Sbjct: 165 --YAFNRVPSLMR-LDLGELKKLEYISEGAFEGL-------------------------- 195
Query: 247 FPIQTLDCKRKELKKVPNNIP-PDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
F ++ L+ +K +PN P + +L++S N ++RP F + LKKL + ++ +
Sbjct: 196 FNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVS 255
Query: 306 FIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
I+ AF GL L EL+L++N+L + + + L +L L L NPW CD +I +L +WL
Sbjct: 256 LIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWL 315
Query: 366 KHH 368
+ +
Sbjct: 316 REY 318
Score = 59.3 bits (142), Expect = 7e-09
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 4/121 (3%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
++ N ++ F LK L + +++S IE AF GL L L L HN + L +
Sbjct: 225 MSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHD 284
Query: 148 VFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ--IPRNRNLGNYAKCESPQEQKNKKLRQ 205
+F L L L+ NPW+C C+I L L+ IP N +C +P + + L +
Sbjct: 285 LFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTC--CGRCHAPMHMRGRYLVE 342
Query: 206 I 206
+
Sbjct: 343 V 343
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 97.8 bits (242), Expect = 2e-20
Identities = 88/335 (26%), Positives = 148/335 (44%), Gaps = 51/335 (15%)
Query: 67 CQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF 126
C R L V P + ++ L N I+ ++ + F + L+ L L +N + KIE AF
Sbjct: 72 CTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFN 131
Query: 127 GLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISML--QIPRNR 184
GL L TL L N++ + + F Y L L L +NP IE++ S ++P R
Sbjct: 132 GLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNP------IESIPSYAFNRVPSLR 185
Query: 185 NLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHN 244
L L ++K + +E E L
Sbjct: 186 RLD---------------LGELKRLEYISEAAFEGL------------------------ 206
Query: 245 YVFPIQTLDCKRKELKKVPN-NIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNG 303
++ L+ LK +PN + +L+LS N+++ +RP F+ + L+KL L
Sbjct: 207 --VNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQ 264
Query: 304 IEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYY 363
+ I+ AF L LEEL+LS+N+L + + + L+ L+ + L NPW C+ ++ +L +
Sbjct: 265 VATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSW 324
Query: 364 WLKHHYNVHFN-GLECKTPEEYKGWSVGKYIRSYY 397
WLK + C P KG +G+ +S++
Sbjct: 325 WLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHF 359
>gi|40217820 slit and trk like 3 protein [Homo sapiens]
Length = 977
Score = 86.3 bits (212), Expect = 5e-17
Identities = 97/362 (26%), Positives = 144/362 (39%), Gaps = 82/362 (22%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L NK+ +N+ F + L+ L N I +IES AF L+KL L+L N I
Sbjct: 127 LKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKRIESGAFRNLSKLRVLILNDNLIP 186
Query: 143 VLTEEVF------------------IYTPLLSY-------LRLYDNPWHCTCEIETLISM 177
+L +F Y +L + L+L +NPW+CTCEI L S
Sbjct: 187 MLPTNLFKAVSLTHLDLRGNRLKVLFYRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSW 246
Query: 178 LQ-IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC---NEEEKEQLDPKPQVSGRPPVI 233
L+ IP +G+ CE+P K LR+I+ +LC ++ E E P S
Sbjct: 247 LERIPYTALVGDIT-CETPFHFHGKDLREIRKTELCPLLSDSEVEASLGIPHSSSSKENA 305
Query: 234 KPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIP-------------------------- 267
P S+ + F +++ K + P P
Sbjct: 306 WPTKPSSMLSSVHFTASSVEYKSSNKQPKPTKQPRTPRPPSTSQALYPGPNQPPIAPYQT 365
Query: 268 ----PDIVKLDLSYN-KINQL------RPKEFEDVHEL-------KKLNLSSNGIEFIDP 309
P I + N IN L + + F ++ EL KKL LSSN I+ I
Sbjct: 366 RPPIPIICPTGCTCNLHINDLGLTVNCKERGFNNISELLPRPLNAKKLYLSSNLIQKIYR 425
Query: 310 AAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNP--------WRCDYNIHYL 361
+ F + L+ L L NN + G +L LK L+L N +R ++HYL
Sbjct: 426 SDFWNFSSLDLLHLGNNRISYVQDGAFINLPNLKSLFLNGNDIEKLTPGMFRGLQSLHYL 485
Query: 362 YY 363
Y+
Sbjct: 486 YF 487
Score = 53.5 bits (127), Expect = 4e-07
Identities = 39/143 (27%), Positives = 64/143 (44%), Gaps = 18/143 (12%)
Query: 81 QDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQ 140
Q L ++ N IR ++ FS LK L L N + + ++AF G + L L L+ N
Sbjct: 480 QSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNLLRTLPTDAFAGTS-LARLNLRKNY 538
Query: 141 IKVLTEEVFIYTPLLSYLR---------LYDNPWHCTCEIETLISMLQIPRNRNLGNYAK 191
F+Y P+ L L +NPW CTC++ ++ + ++
Sbjct: 539 --------FLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQWIETISSVSVVGDVL 590
Query: 192 CESPQEQKNKKLRQIKSEQLCNE 214
C SP+ ++ +R I+ E LC E
Sbjct: 591 CRSPENLTHRDVRTIELEVLCPE 613
Score = 48.9 bits (115), Expect = 9e-06
Identities = 39/132 (29%), Positives = 62/132 (46%), Gaps = 6/132 (4%)
Query: 273 LDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFD 332
L YN I ++ F ++ +L+ L L+ N I + F ++ L LDL N L+
Sbjct: 154 LQADYNVIKRIESGAFRNLSKLRVLILNDNLIPMLPTNLFKAVS-LTHLDLRGNRLKVLF 212
Query: 333 Y-GVLEDL-YFLKLLWLRDNPWRCDYNIHYLYYWLKH-HYNVHFNGLECKTPEEYKGWSV 389
Y G+L+ + L L L +NPW C I L WL+ Y + C+TP + G +
Sbjct: 213 YRGMLDHIGRSLMELQLEENPWNCTCEIVQLKSWLERIPYTALVGDITCETPFHFHGKDL 272
Query: 390 GKYIRSYYEECP 401
+ ++ E CP
Sbjct: 273 REIRKT--ELCP 282
Score = 47.0 bits (110), Expect = 3e-05
Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 25/140 (17%)
Query: 268 PDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNS 327
P++ L L+ N I +L P F + L L N I I PAAF + +L+ L L+NN
Sbjct: 456 PNLKSLFLNGNDIEKLTPGMFRGLQSLHYLYFEFNVIREIQPAAFSLMPNLKLLFLNNNL 515
Query: 328 LQN--------------------FDY----GVLEDLYFLKLLWLRDNPWRCDYNIHYLYY 363
L+ F Y GVLE L + + L +NPW C ++
Sbjct: 516 LRTLPTDAFAGTSLARLNLRKNYFLYLPVAGVLEHLNAIVQIDLNENPWDCTCDLVPFKQ 575
Query: 364 WLKHHYNVHFNG-LECKTPE 382
W++ +V G + C++PE
Sbjct: 576 WIETISSVSVVGDVLCRSPE 595
Score = 43.1 bits (100), Expect = 5e-04
Identities = 24/74 (32%), Positives = 36/74 (48%)
Query: 86 MLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLT 145
+ L RN +R L N F S++L N + I++ AF GL L L L N++ V
Sbjct: 82 LYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFR 141
Query: 146 EEVFIYTPLLSYLR 159
+ F+ L YL+
Sbjct: 142 NDTFLGLESLEYLQ 155
Score = 42.0 bits (97), Expect = 0.001
Identities = 24/80 (30%), Positives = 39/80 (48%)
Query: 271 VKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQN 330
V ++L N + ++ F + LK+L L N ++ FLGL LE L N ++
Sbjct: 104 VSINLGNNALQDIQTGAFNGLKILKRLYLHENKLDVFRNDTFLGLESLEYLQADYNVIKR 163
Query: 331 FDYGVLEDLYFLKLLWLRDN 350
+ G +L L++L L DN
Sbjct: 164 IESGAFRNLSKLRVLILNDN 183
Score = 35.8 bits (81), Expect = 0.080
Identities = 19/55 (34%), Positives = 29/55 (52%)
Query: 296 KLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
KL L N + + +FL L + ++L NN+LQ+ G L LK L+L +N
Sbjct: 81 KLYLQRNSMRKLYTNSFLHLNNAVSINLGNNALQDIQTGAFNGLKILKRLYLHEN 135
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 84.7 bits (208), Expect = 1e-16
Identities = 75/299 (25%), Positives = 126/299 (42%), Gaps = 53/299 (17%)
Query: 54 CDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQ 113
C + + + C + L V P D + L NKI+ +K N F L L L
Sbjct: 75 CPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILN 134
Query: 114 QNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPL-LSYLRLYDNPWHCTCEIE 172
N+++KI +AF KL L L HNQ+ E+ + P L+ LR+++N
Sbjct: 135 NNKLTKIHPKAFLTTKKLRRLYLSHNQLS----EIPLNLPKSLAELRIHEN--------- 181
Query: 173 TLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKS-EQLCNEEEKEQLDPKPQVSGRPP 231
K + Q+ K + + E N + ++P
Sbjct: 182 ------------------KVKKIQKDTFKGMNALHVLEMSANPLDNNGIEP--------- 214
Query: 232 VIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDV 291
F VF I+ + K L VP +PP +++L L YNKI+ + ++F+
Sbjct: 215 -------GAFEGVTVFHIRIAEAK---LTSVPKGLPPTLLELHLDYNKISTVELEDFKRY 264
Query: 292 HELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
EL++L L +N I I+ + + + E+ L NN L+ G L +L +L++++L N
Sbjct: 265 KELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSG-LPELKYLQIIFLHSN 322
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 83.6 bits (205), Expect = 3e-16
Identities = 83/340 (24%), Positives = 139/340 (40%), Gaps = 30/340 (8%)
Query: 63 KYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIES 122
K + C+ +KL + L + L N ++ LK N F +L L L N IS I+
Sbjct: 43 KMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDE 102
Query: 123 EAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC--TCEIETLISMLQI 180
AF G+ +L L+L N+I F L L L N H + + L +L +
Sbjct: 103 NAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSL 162
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDST 240
N Q+ +N +L + + I+ +
Sbjct: 163 HLRSNSLRTIPVRIFQDCRNLELLDLGYNR----------------------IRSLARNV 200
Query: 241 FCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLD---LSYNKINQLRPKEFEDVHELKKL 297
F + ++ L + + K+ + P +V L L +NKI+ + L++L
Sbjct: 201 FAG--MIRLKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRL 258
Query: 298 NLSSNGIE-FIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDY 356
+LS N IE F P+ F + +L+ L+L +N L +L+ L + L N W C
Sbjct: 259 DLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSR 318
Query: 357 NIHYLYYWLKHHYNVHFNGLECKTPEEYKGWSVGKYIRSY 396
NI L WLK + N + C +P+E +G +V +++Y
Sbjct: 319 NICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNY 358
Score = 42.0 bits (97), Expect = 0.001
Identities = 48/198 (24%), Positives = 81/198 (40%), Gaps = 42/198 (21%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI-------------------ESE 123
L + L N+ L +F + L++L LQ N+IS I E E
Sbjct: 207 LKELHLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIE 266
Query: 124 AFFG------LNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISM 177
AF G + L L L N++ + +E+ L+ + L N W C+ I +L++
Sbjct: 267 AFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNW 326
Query: 178 LQIPRNRNLGNYAKCESPQE-QKNKKLRQIKSEQLCNEEEKEQLD--------------P 222
L+ + N C SP+E Q + +K+ +C + E+ D P
Sbjct: 327 LKSFKGLR-ENTIICASPKELQGVNVIDAVKNYSICGKSTTERFDLARALPKPTFKPKLP 385
Query: 223 KPQVSGRPPVIKPEVDST 240
+P+ +PP + P V +T
Sbjct: 386 RPKHESKPP-LPPTVGAT 402
>gi|16418445 leucine rich repeat containing 3B [Homo sapiens]
Length = 259
Score = 83.2 bits (204), Expect = 4e-16
Identities = 46/128 (35%), Positives = 72/128 (56%), Gaps = 4/128 (3%)
Query: 254 CKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFL 313
C LK++P ++PP+ V L L N+I + + F+D+H+L+ LNLS NGIEFID AF
Sbjct: 50 CSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFK 109
Query: 314 GLTH-LEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVH 372
G+ L+ LDLS+N +Q+ +L + +NPW CD + + + ++
Sbjct: 110 GVAETLQTLDLSDNRIQSVHKNAFNNL--KARARIANNPWHCDCTLQQVLRSMASNHETA 167
Query: 373 FNGLECKT 380
N + CKT
Sbjct: 168 HNVI-CKT 174
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/110 (29%), Positives = 58/110 (52%), Gaps = 3/110 (2%)
Query: 67 CQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFF 126
C L + P + + + L N+I ++ N +F +L+ L+L +N I I+ AF
Sbjct: 50 CSNANLKEIPRDLPPETVLLYLDSNQITSIPNEIFKDLHQLRVLNLSKNGIEFIDEHAFK 109
Query: 127 GLNK-LTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLI 175
G+ + L TL L N+I+ + + F L + R+ +NPWHC C ++ ++
Sbjct: 110 GVAETLQTLDLSDNRIQSVHKNAF--NNLKARARIANNPWHCDCTLQQVL 157
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 82.0 bits (201), Expect = 1e-15
Identities = 101/373 (27%), Positives = 152/373 (40%), Gaps = 39/373 (10%)
Query: 37 GGRRGSNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTL 96
G RG + AP P ++ C+ L V G+P D + L RN ++
Sbjct: 382 GPPRGPGEERAVAP-CPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSV 440
Query: 97 KNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLS 156
F L SL LQ I+++E+ A GL +L L L NQ+ L+ P L
Sbjct: 441 PRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLG 500
Query: 157 YLRLYDNPWHCT--CEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIK-SEQLCN 213
YL L N + + L S+ + N + + + + LR + S
Sbjct: 501 YLYLERNRFLQVPGAALRALPSLFSLHLQDNAVD--RLAPGDLGRTRALRWVYLSGNRIT 558
Query: 214 EEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIP---PDI 270
E L P + ++ L R +L++VP P +
Sbjct: 559 EVSLGALGPARE-----------------------LEKLHLDRNQLREVPTGALEGLPAL 595
Query: 271 VKLDLSYNKINQLRPKEFEDV-HELKKLNLSSNGIEFIDPAAFLGL-THLEELDLSNNSL 328
++L LS N + LR F+ V L+ L L+S+G+E I P AF GL L+ L L N L
Sbjct: 596 LELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQL 655
Query: 329 QNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGLECKTPEEYKGWS 388
+ L L L+L+ L NP+ CD + L+ WL N+ G C TP +G
Sbjct: 656 RALP--ALPSLSQLELIDLSSNPFHCDCQLLPLHRWLT-GLNLRV-GATCATPPNARGQR 711
Query: 389 VGKYIRSYYEECP 401
V K + +E+CP
Sbjct: 712 V-KAAAAVFEDCP 723
Score = 65.1 bits (157), Expect = 1e-10
Identities = 78/313 (24%), Positives = 118/313 (37%), Gaps = 45/313 (14%)
Query: 76 LPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLL 135
L G P L + L N+++ L + S+ + L L+L N ++ E L L LL
Sbjct: 202 LAGLPA-LRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELL 260
Query: 136 LQHNQIKVLTEEVFIYTPLLSYL----------------------RLYDNPWHCTCEIET 173
L ++ L F + P L L RL NP C C+
Sbjct: 261 LDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARP 320
Query: 174 LISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL-CN---EEEKEQLDPK------ 223
L+ L R R+ G C+ P+ + + L ++ L C +E+E+L+ +
Sbjct: 321 LLEWLARARVRSDG---ACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPR 377
Query: 224 ------PQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSY 277
P+ G + P + C V + C+ L+ VP P D LDL
Sbjct: 378 APPRGPPRGPGEERAVAPCPRACVC---VPESRHSSCEGCGLQAVPRGFPSDTQLLDLRR 434
Query: 278 NKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLE 337
N + F + L L+L GI ++ A GL L L LS+N L LE
Sbjct: 435 NHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALE 494
Query: 338 DLYFLKLLWLRDN 350
L L+L N
Sbjct: 495 GAPRLGYLYLERN 507
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/97 (31%), Positives = 48/97 (49%)
Query: 254 CKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFL 313
C+ + L +VP+ IP +LDL N + + F+ V L L+L +E + AF
Sbjct: 48 CRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFR 107
Query: 314 GLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
GL L L+L++N L+ L+ L L+ L L N
Sbjct: 108 GLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGN 144
Score = 42.0 bits (97), Expect = 0.001
Identities = 27/79 (34%), Positives = 40/79 (50%)
Query: 272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNF 331
+L+L N + +LRP F + L LNL+ N + ++ AF GL + L LS+N+L
Sbjct: 138 RLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVL 197
Query: 332 DYGVLEDLYFLKLLWLRDN 350
L L L+ L L N
Sbjct: 198 APEALAGLPALRRLSLHHN 216
Score = 38.1 bits (87), Expect = 0.016
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 250 QTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEF 306
Q LD + LK +P P + LDL + ++ + F + L LNL+SN +
Sbjct: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
Query: 307 IDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
+ A GL L L+L N+L+ G L L L L N
Sbjct: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHN 168
Score = 37.7 bits (86), Expect = 0.021
Identities = 30/106 (28%), Positives = 46/106 (43%), Gaps = 3/106 (2%)
Query: 61 HEKYLDCQERKLVYVLPGWPQDLLHMLL---ARNKIRTLKNNMFSKFKKLKSLDLQQNEI 117
H +LD + ++ V G + L +LL A N +R L L+ L+L+ N +
Sbjct: 87 HLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNAL 146
Query: 118 SKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
++ F L L TL L HN + L F + +LRL N
Sbjct: 147 EELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHN 192
Score = 36.6 bits (83), Expect = 0.047
Identities = 25/77 (32%), Positives = 35/77 (45%)
Query: 88 LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
LA N + L F +++ L L N +S + EA GL L L L HN+++ L
Sbjct: 165 LAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGP 224
Query: 148 VFIYTPLLSYLRLYDNP 164
V L+ L L NP
Sbjct: 225 VLSQARGLARLELGHNP 241
Score = 32.3 bits (72), Expect = 0.88
Identities = 21/59 (35%), Positives = 30/59 (50%)
Query: 295 KKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWR 353
++L+L N ++ I AAF G+ HL LDL + ++ G L L LL L N R
Sbjct: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLR 123
Score = 31.6 bits (70), Expect = 1.5
Identities = 20/54 (37%), Positives = 29/54 (53%)
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
LDLQ N + I + AF G+ LT L L+H +++++ E F L L L N
Sbjct: 67 LDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASN 120
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 80.9 bits (198), Expect = 2e-15
Identities = 77/302 (25%), Positives = 117/302 (38%), Gaps = 52/302 (17%)
Query: 51 GLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSL 110
G C H + + C + L V P D + L NKI +K+ F K L +L
Sbjct: 51 GPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
Query: 111 DLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCE 170
L N+ISK+ AF L KL L L NQ+K L E++ L LR ++N +
Sbjct: 111 ILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRK 167
Query: 171 I--ETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSG 228
+ L M+ I N + E+ Q KKL I+
Sbjct: 168 VTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADT----------------- 210
Query: 229 RPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEF 288
+ +P +PP + +L L NKI+++
Sbjct: 211 -----------------------------NITSIPQGLPPSLTELHLDGNKISRVDAASL 241
Query: 289 EDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLR 348
+ ++ L KL LS N I +D + HL EL L NN L G+ E Y +++++L
Sbjct: 242 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKY-IQVVYLH 300
Query: 349 DN 350
+N
Sbjct: 301 NN 302
Score = 29.3 bits (64), Expect = 7.5
Identities = 23/102 (22%), Positives = 43/102 (42%), Gaps = 3/102 (2%)
Query: 41 GSNPVKRYAPGLPCDVYTYLHE-KYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNN 99
G+NP+K + G+ + + + Y+ + + + G P L + L NKI +
Sbjct: 182 GTNPLK--SSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 100 MFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
L L L N IS +++ + L L L +N++
Sbjct: 240 SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 281
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 80.9 bits (198), Expect = 2e-15
Identities = 77/302 (25%), Positives = 117/302 (38%), Gaps = 52/302 (17%)
Query: 51 GLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKSL 110
G C H + + C + L V P D + L NKI +K+ F K L +L
Sbjct: 51 GPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHAL 110
Query: 111 DLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCE 170
L N+ISK+ AF L KL L L NQ+K L E++ L LR ++N +
Sbjct: 111 ILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKM---PKTLQELRAHENEITKVRK 167
Query: 171 I--ETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSG 228
+ L M+ I N + E+ Q KKL I+
Sbjct: 168 VTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADT----------------- 210
Query: 229 RPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEF 288
+ +P +PP + +L L NKI+++
Sbjct: 211 -----------------------------NITSIPQGLPPSLTELHLDGNKISRVDAASL 241
Query: 289 EDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLR 348
+ ++ L KL LS N I +D + HL EL L NN L G+ E Y +++++L
Sbjct: 242 KGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKY-IQVVYLH 300
Query: 349 DN 350
+N
Sbjct: 301 NN 302
Score = 29.3 bits (64), Expect = 7.5
Identities = 23/102 (22%), Positives = 43/102 (42%), Gaps = 3/102 (2%)
Query: 41 GSNPVKRYAPGLPCDVYTYLHE-KYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNN 99
G+NP+K + G+ + + + Y+ + + + G P L + L NKI +
Sbjct: 182 GTNPLK--SSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAA 239
Query: 100 MFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
L L L N IS +++ + L L L +N++
Sbjct: 240 SLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 281
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 80.9 bits (198), Expect = 2e-15
Identities = 96/372 (25%), Positives = 144/372 (38%), Gaps = 37/372 (9%)
Query: 96 LKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLL 155
L N+FS L L L N + + F L L +L LQ NQ++ L +F L
Sbjct: 112 LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171
Query: 156 SYLRLYDNP--------WHCTCEIETLISMLQIPRNRNLGNYAKCESPQE------QKNK 201
L L N +H ++TL G + K S QE ++
Sbjct: 172 KTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISE 231
Query: 202 KLRQIKSEQLCNEE---EKEQLDPKPQ-----------VSGRPPVIKPEVDSTFCHNYVF 247
Q+ S+ C E ++ + P +S + +++ F H
Sbjct: 232 LPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPC- 290
Query: 248 PIQTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGI 304
+ L +L+ V ++ L LSYN I L F D+ EL KL L SN +
Sbjct: 291 -LVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNL 349
Query: 305 EFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYW 364
+ PA F L+ LE L LS N L G+ + Y L L L NPW+CD ++ YL+ W
Sbjct: 350 TALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNW 409
Query: 365 LKHHYNVHFN-GLECKTPEEYKGWSVGKYIRSYYEECP--KDKLPAYPESFDQDTEDDEW 421
L+ + + N C P KG V + CP +D L D+ W
Sbjct: 410 LQQYTDRLLNIQTYCAGPAYLKG-QVVPALNEKQLVCPVTRDHLGFQVTWPDESKAGGSW 468
Query: 422 EKKHRDHTAKKQ 433
+ ++ A+ Q
Sbjct: 469 DLAVQERAARSQ 480
Score = 62.4 bits (150), Expect = 8e-10
Identities = 39/130 (30%), Positives = 60/130 (46%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L ++L+ N I L +F ++L L L N ++ + F L+KL L L NQ+
Sbjct: 314 NLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQL 373
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNK 201
L E +F L L L+ NPW C C + L + LQ +R L C P K +
Sbjct: 374 TTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQ 433
Query: 202 KLRQIKSEQL 211
+ + +QL
Sbjct: 434 VVPALNEKQL 443
Score = 46.6 bits (109), Expect = 5e-05
Identities = 35/102 (34%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 76 LPGWPQ-------DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGL 128
L G PQ L + L N I L +FS+ L+ L LQ+N I+ + F L
Sbjct: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
Query: 129 NKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCE 170
LT L LQ N ++VL +F +TP L L L N E
Sbjct: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAE 306
Score = 33.9 bits (76), Expect = 0.30
Identities = 25/81 (30%), Positives = 36/81 (44%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L RN I L ++F+ L L LQ N + + + F L L L HNQ++
Sbjct: 243 LERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLE 302
Query: 143 VLTEEVFIYTPLLSYLRLYDN 163
+ E F + L L L N
Sbjct: 303 TVAEGTFAHLSNLRSLMLSYN 323
>gi|27436867 slit and trk like 4 protein [Homo sapiens]
Length = 837
Score = 80.5 bits (197), Expect = 3e-15
Identities = 84/352 (23%), Positives = 141/352 (40%), Gaps = 85/352 (24%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L + L N+++ L+ + F + L+ L N I IE AF L+KL L+L N I
Sbjct: 109 LKQLHLNNNELKILRADTFLGIENLEYLQADYNLIKYIERGAFNKLHKLKVLILNDNLIS 168
Query: 143 VLTEEVFIYTPL------------LSY------------LRLYDNPWHCTCEIETLISML 178
L + +F + L L Y L+L DNPW+C+C++ L + L
Sbjct: 169 FLPDNIFRFASLTHLDIRGNRIQKLPYIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWL 228
Query: 179 Q-IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC------------------------- 212
+ +P N +G A CE+P + + L++ ++LC
Sbjct: 229 ENMPYNIYIGE-AICETPSDLYGRLLKETNKQELCPMGTGSDFDVRILPPSQLENGYTTP 287
Query: 213 ----NEEEKEQLDPKP-------QVSG--------------------RPPVIKPEVDSTF 241
+ +L KP ++SG R P + P F
Sbjct: 288 NGHTTQTSLHRLVTKPPKTTNPSKISGIVAGKALSNRNLSQIVSYQTRVPPLTPCPAPCF 347
Query: 242 CHNYVFPI-QTLDCKRKELKKVPNNIPPDI--VKLDLSYNKINQLRPKEFEDVHELKKLN 298
C + + +++C+ K ++ + IP + KL ++ N I + +F D L L+
Sbjct: 348 CKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKDVDVSDFTDFEGLDLLH 407
Query: 299 LSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
L SN I I F LT+L L L+ N ++ + L+ L+ L+L N
Sbjct: 408 LGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYN 459
Score = 64.7 bits (156), Expect = 2e-10
Identities = 40/116 (34%), Positives = 57/116 (49%), Gaps = 3/116 (2%)
Query: 273 LDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFD 332
L YN I + F +H+LK L L+ N I F+ P L LD+ N +Q
Sbjct: 136 LQADYNLIKYIERGAFNKLHKLKVLILNDNLISFL-PDNIFRFASLTHLDIRGNRIQKLP 194
Query: 333 Y-GVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKH-HYNVHFNGLECKTPEEYKG 386
Y GVLE + + L L DNPW C ++ L WL++ YN++ C+TP + G
Sbjct: 195 YIGVLEHIGRVVELQLEDNPWNCSCDLLPLKAWLENMPYNIYIGEAICETPSDLYG 250
Score = 61.6 bits (148), Expect = 1e-09
Identities = 51/203 (25%), Positives = 82/203 (40%), Gaps = 54/203 (26%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
DLLH L N+I +K ++F L+ L L N+I ++ E F GL+ L L L++N I
Sbjct: 404 DLLH--LGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLI 461
Query: 142 KV---------------------------------------LTEEVFIYTPL-------- 154
K L F+Y P+
Sbjct: 462 KEISAGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQ 521
Query: 155 -LSYLRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC- 212
L+ + L NPW CTC++ L ++ + + KCE+P + N +L+ +K+E LC
Sbjct: 522 SLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKELKCETPVQFANIELKSLKNEILCP 581
Query: 213 ---NEEEKEQLDPKPQVSGRPPV 232
N+ P P ++ P+
Sbjct: 582 KLLNKPSAPFTSPAPAITFTTPL 604
Score = 51.2 bits (121), Expect = 2e-06
Identities = 34/110 (30%), Positives = 53/110 (48%), Gaps = 6/110 (5%)
Query: 54 CDVYTYLHEKYLDCQERKLVY----VLPGWPQDLLHMLLARNKIRTLKNNMFSKFKKLKS 109
C + + Y++C E+ VY + P W + H+ N + L N F F S
Sbjct: 30 CSCVSVENVLYVNC-EKVSVYRPNQLKPPW-SNFYHLNFQNNFLNILYPNTFLNFSHAVS 87
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLR 159
L L N++ IE AF GL+ L L L +N++K+L + F+ L YL+
Sbjct: 88 LHLGNNKLQNIEGGAFLGLSALKQLHLNNNELKILRADTFLGIENLEYLQ 137
Score = 49.3 bits (116), Expect = 7e-06
Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 25/138 (18%)
Query: 272 KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQN- 330
+L L+ N+I +L P+ F +H L+ L L N I+ I F + +L+ L L+NN L++
Sbjct: 429 RLYLNGNQIERLYPEIFSGLHNLQYLYLEYNLIKEISAGTFDSMPNLQLLYLNNNLLKSL 488
Query: 331 -------------------FDY----GVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL-K 366
F Y GVL+ L L + L NPW C ++ L W+ K
Sbjct: 489 PVYIFSGAPLARLNLRNNKFMYLPVSGVLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEK 548
Query: 367 HHYNVHFNGLECKTPEEY 384
+ L+C+TP ++
Sbjct: 549 LSDGIVVKELKCETPVQF 566
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/103 (32%), Positives = 51/103 (49%), Gaps = 6/103 (5%)
Query: 65 LDCQERKLVYVLPGWPQDL----LHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKI 120
++CQE+ + + P+ L LH+ N I+ + + F+ F+ L L L N+I+ I
Sbjct: 359 VNCQEKNIQSMSELIPKPLNAKKLHV--NGNSIKDVDVSDFTDFEGLDLLHLGSNQITVI 416
Query: 121 ESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
+ + F L L L L NQI+ L E+F L YL L N
Sbjct: 417 KGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNLQYLYLEYN 459
>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
sapiens]
Length = 345
Score = 80.1 bits (196), Expect = 4e-15
Identities = 58/206 (28%), Positives = 94/206 (45%), Gaps = 53/206 (25%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAA 311
+DC ++ L ++P+++PP L L N+I+ L F V L LNLS+N + + P A
Sbjct: 34 VDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLNLSNNSLSNLAPGA 93
Query: 312 FLGLTHLE------------------------ELDLSNNS-------------------- 327
F GL HL+ ELDLS+N+
Sbjct: 94 FHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLPTSLGETWENLTILAV 153
Query: 328 ----LQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKH--HYNVHFNGLECKTP 381
LQ D +LE + ++LL L+DN W+C+ ++ L WL+ + +G+ C++P
Sbjct: 154 QQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFVYKGGLTDGIICESP 213
Query: 382 EEYKGWSVGKYIRSYYEECPKDKLPA 407
+ +KG + + Y+ CP LPA
Sbjct: 214 DTWKGKDLLRIPHELYQPCP---LPA 236
Score = 60.5 bits (145), Expect = 3e-09
Identities = 44/149 (29%), Positives = 66/149 (44%), Gaps = 4/149 (2%)
Query: 65 LDCQERKLVYVLPGWPQDLLHML---LARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIE 121
L+ L + PG L H+ L +N + +L++ +F +L+ LDL N IS +
Sbjct: 79 LNLSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHLP 138
Query: 122 SEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-I 180
+ LT L +Q NQ++ L + P + L L DN W C C + L L+
Sbjct: 139 TSLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKF 198
Query: 181 PRNRNLGNYAKCESPQEQKNKKLRQIKSE 209
L + CESP K K L +I E
Sbjct: 199 VYKGGLTDGIICESPDTWKGKDLLRIPHE 227
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 79.0 bits (193), Expect = 8e-15
Identities = 95/367 (25%), Positives = 137/367 (37%), Gaps = 79/367 (21%)
Query: 52 LPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRT---------------- 95
L C ++ C ER L V G P+ + + L N+I
Sbjct: 34 LACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTV 93
Query: 96 -LKNNMFSKF-----KKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVF 149
L N +F K ++ L LQ+N I I A L KL L L N I + E
Sbjct: 94 YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDG 153
Query: 150 IYTPLLSYLRLYDNPWHCTCEIETL---ISMLQIPRNRNLGNYAKCESPQEQKNKKLRQI 206
+ +S L+ + H + L + L++ NR + I
Sbjct: 154 AFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENR------------------IAVI 195
Query: 207 KSEQLCNEEEKEQLDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNI 266
N E+L V G K + TF H K KE V N++
Sbjct: 196 SDMAFQNLTSLERLI----VDGNLLTNKGIAEGTFSHL---------TKLKEFSIVRNSL 242
Query: 267 ---PPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDL 323
PPD+ L +L L N I I AF L LE LD+
Sbjct: 243 SHPPPDLPGTHLI-------------------RLYLQDNQINHIPLTAFSNLRKLERLDI 283
Query: 324 SNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKH-HYNVHFNGLECKTPE 382
SNN L+ GV ++L LK L R+NPW CD +I ++ WLK+ +++ G C+ PE
Sbjct: 284 SNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPE 343
Query: 383 EYKGWSV 389
+ +G +V
Sbjct: 344 QVRGMAV 350
Score = 59.7 bits (143), Expect = 5e-09
Identities = 34/103 (33%), Positives = 56/103 (54%), Gaps = 2/103 (1%)
Query: 110 LDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTC 169
L LQ N+I+ I AF L KL L + +NQ+++LT+ VF L L +NPW C C
Sbjct: 257 LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDC 316
Query: 170 EIETLISMLQ-IPRNRNLGNYAKCESPQEQKNKKLRQIKSEQL 211
I+ + L+ IP + N+ + C+ P++ + +R++ L
Sbjct: 317 SIKWVTEWLKYIPSSLNVRGF-MCQGPEQVRGMAVRELNMNLL 358
>gi|85986601 relaxin/insulin-like family peptide receptor 1 [Homo
sapiens]
Length = 757
Score = 77.8 bits (190), Expect = 2e-14
Identities = 91/323 (28%), Positives = 129/323 (39%), Gaps = 39/323 (12%)
Query: 41 GSNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLKNNM 100
GS PV+ GL LDC E L V P ++ M L N IR L +
Sbjct: 98 GSVPVQCLCQGLE-----------LDCDETNLRAV-PSVSSNVTAMSLQWNLIRKLPPDC 145
Query: 101 FSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRL 160
F + L+ L LQ N+I+ I AF GLN LT L L HN+I L VF L +L +
Sbjct: 146 FKNYHDLQKLYLQNNKITSISIYAFRGLNSLTKLYLSHNRITFLKPGVFEDLHRLEWLII 205
Query: 161 YDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCNEEEK-EQ 219
DN +S + P L + N L ++ + LC +
Sbjct: 206 EDNH----------LSRISPPTFYGLNSLILL----VLMNNVLTRLPDKPLCQHMPRLHW 251
Query: 220 LDPKPQVSGRPPVIKPEVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVK---LDLS 276
LD + G + C N + L ++ ++ + N + K LDL
Sbjct: 252 LD----LEGNHIHNLRNLTFISCSN----LTVLVMRKNKINHLNENTFAPLQKLDELDLG 303
Query: 277 YNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVL 336
NKI L P F+D+ EL +LNLS N I+ I F L L+ L L + N +
Sbjct: 304 SNKIENLPPLIFKDLKELSQLNLSYNPIQKIQANQFDYLVKLKSLSLEGIEISNIQQRMF 363
Query: 337 EDLYFLKLLWLRDNPWRCDYNIH 359
L L ++ + + C Y H
Sbjct: 364 RPLMNLSHIYFKKFQY-CGYAPH 385
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 75.5 bits (184), Expect = 9e-14
Identities = 82/348 (23%), Positives = 135/348 (38%), Gaps = 65/348 (18%)
Query: 64 YLDCQERKLVYVLPGWPQDLLHMLLARNKIRT------LKNNMFSKFKKLKSLDLQQNEI 117
++ C +R L + G P+D + L N+I LKN + K++ + L N +
Sbjct: 41 FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL-----KVERIYLYHNSL 95
Query: 118 SKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISM 177
+ + + L LQ N I+ +T + P L L L DN +S
Sbjct: 96 DEFPTNL---PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNS----------VSA 142
Query: 178 LQIPRNR-NLGNYAKCESPQEQKNKKL-----RQIKSEQLCNEEEKEQLDPKPQVSGRPP 231
+ I NY + + R I E+L ++ + P + G
Sbjct: 143 VSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTI--EELRLDDNRISTISSPSLQGLTS 200
Query: 232 VIKPEVDSTFCHNY---------VFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQ 282
+ + +D +N+ + + L R L P N+P
Sbjct: 201 LKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT------------- 247
Query: 283 LRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFL 342
L+KL L N I + P AF L L LD+SNN+L N G+ +DL +
Sbjct: 248 ----------NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 343 KLLWLRDNPWRCDYNIHYLYYWLKH-HYNVHFNGLECKTPEEYKGWSV 389
L LR+NPW C + ++ WL+ V+ GL C+ PE+ +G ++
Sbjct: 298 TQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAI 345
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/129 (25%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L + L RN + N+ L+ L LQ N I+++ AF L +L L + +N +
Sbjct: 226 NLTELSLVRNSLTAAPVNLPGT--NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-IPRNRNLGNYAKCESPQEQKN 200
L + +F ++ L L +NPW+C C+++ + LQ +P N+ C++P++ +
Sbjct: 284 SNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRG-LMCQAPEKVRG 342
Query: 201 KKLRQIKSE 209
++ + +E
Sbjct: 343 MAIKDLNAE 351
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 75.5 bits (184), Expect = 9e-14
Identities = 82/348 (23%), Positives = 135/348 (38%), Gaps = 65/348 (18%)
Query: 64 YLDCQERKLVYVLPGWPQDLLHMLLARNKIRT------LKNNMFSKFKKLKSLDLQQNEI 117
++ C +R L + G P+D + L N+I LKN + K++ + L N +
Sbjct: 41 FIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLL-----KVERIYLYHNSL 95
Query: 118 SKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISM 177
+ + + L LQ N I+ +T + P L L L DN +S
Sbjct: 96 DEFPTNL---PKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNS----------VSA 142
Query: 178 LQIPRNR-NLGNYAKCESPQEQKNKKL-----RQIKSEQLCNEEEKEQLDPKPQVSGRPP 231
+ I NY + + R I E+L ++ + P + G
Sbjct: 143 VSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTI--EELRLDDNRISTISSPSLQGLTS 200
Query: 232 VIKPEVDSTFCHNY---------VFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQ 282
+ + +D +N+ + + L R L P N+P
Sbjct: 201 LKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGT------------- 247
Query: 283 LRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFL 342
L+KL L N I + P AF L L LD+SNN+L N G+ +DL +
Sbjct: 248 ----------NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNI 297
Query: 343 KLLWLRDNPWRCDYNIHYLYYWLKH-HYNVHFNGLECKTPEEYKGWSV 389
L LR+NPW C + ++ WL+ V+ GL C+ PE+ +G ++
Sbjct: 298 TQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAI 345
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/129 (25%), Positives = 66/129 (51%), Gaps = 4/129 (3%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L + L RN + N+ L+ L LQ N I+++ AF L +L L + +N +
Sbjct: 226 NLTELSLVRNSLTAAPVNLPGT--NLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNL 283
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-IPRNRNLGNYAKCESPQEQKN 200
L + +F ++ L L +NPW+C C+++ + LQ +P N+ C++P++ +
Sbjct: 284 SNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRG-LMCQAPEKVRG 342
Query: 201 KKLRQIKSE 209
++ + +E
Sbjct: 343 MAIKDLNAE 351
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 75.1 bits (183), Expect = 1e-13
Identities = 48/143 (33%), Positives = 69/143 (48%), Gaps = 5/143 (3%)
Query: 249 IQTLDCKRKELKKVPNNIPPDIV---KLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
+Q LD L ++P +I D+ +L L N I L L+ L+LS NG+
Sbjct: 94 LQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLA 153
Query: 306 FIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
+ P F GL L L L +N LQN D E L L+LL + DNPW CD N+ +W+
Sbjct: 154 QLPPGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWM 213
Query: 366 K--HHYNVHFNGLECKTPEEYKG 386
+ + + L C P+E +G
Sbjct: 214 EWFSYRGGRLDQLACTLPKELRG 236
Score = 60.8 bits (146), Expect = 2e-09
Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 5/153 (3%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
+L + L N IRTL ++ L+ LDL N ++++ F GL L +L L+ N++
Sbjct: 117 NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLPPGLFDGLLALRSLSLRSNRL 176
Query: 142 KVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ--IPRNRNLGNYAKCESPQEQK 199
+ L F L L++ DNPW C C + ++ R L A C P+E +
Sbjct: 177 QNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWFSYRGGRLDQLA-CTLPKELR 235
Query: 200 NKKLRQIKSEQL--CNEEEKEQLDPKPQVSGRP 230
K +R + E C++ E E + G P
Sbjct: 236 GKDMRMVPMEMFNYCSQLEDENSSAGLDIPGPP 268
Score = 38.1 bits (87), Expect = 0.016
Identities = 29/92 (31%), Positives = 41/92 (44%)
Query: 295 KKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRC 354
+ L L +N + + AF L+ L+ LDLSNN L + DL L L LR+N R
Sbjct: 71 RTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRT 130
Query: 355 DYNIHYLYYWLKHHYNVHFNGLECKTPEEYKG 386
+ L H ++ NGL P + G
Sbjct: 131 LDRDLLRHSPLLRHLDLSINGLAQLPPGLFDG 162
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/360 (26%), Positives = 137/360 (38%), Gaps = 82/360 (22%)
Query: 63 KYLDCQERKLVYVLPGWPQ---DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISK 119
+YL KL + G Q L +LL+ N++ ++ FS+ LK L L N +
Sbjct: 110 RYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEY 169
Query: 120 IESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ 179
I AF L LT L L N + ++ VF + L LRLY+N +
Sbjct: 170 IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN------------RLTD 217
Query: 180 IPRNRNLGNYAKCESPQEQ--KNKKLRQIKSEQLCNEEEKEQLD-PKPQVSGRPPVIKPE 236
IP +G + + QE + ++ + N ++L +S PP I +
Sbjct: 218 IP----MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 273
Query: 237 VDSTFCHNYVFPIQTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHE 293
+ + L LK++ I P++ +L L N I+ L F ++ +
Sbjct: 274 LPQ---------LNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 324
Query: 294 LKKLNLSSNGIEFIDPAAFLGLTHLEELDL------------------------------ 323
L+ L LS N I FI P AF GLT L EL L
Sbjct: 325 LQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR 384
Query: 324 ------------------SNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
NN L+N G+ + L L L L DNPWRCD +I L WL
Sbjct: 385 QLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 444
Score = 66.6 bits (161), Expect = 4e-11
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 LPCDVYTYLHE-KYLDCQERKLVYVLPG---WPQDLLHMLLARNKIRTLKNNMFSKFKKL 107
LP +V++ L + + L ++ ++ PG +L + L N ++ L N+F L
Sbjct: 314 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 373
Query: 108 KSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC 167
+++ LQ N + ++ F +N L + LQ+NQ++ L +F + L LRLYDNPW C
Sbjct: 374 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRC 433
Query: 168 TCEIETLISMLQIPRNR-NLGNYAKCESPQEQKNKKL 203
+I L + L + + R C SP + + L
Sbjct: 434 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 470
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/99 (29%), Positives = 45/99 (45%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAA 311
++C + VP +P + + L + I +L F ++ L L + N + I P A
Sbjct: 43 VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGA 102
Query: 312 FLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
F L L L L+NN LQ G+ + L L+ L L N
Sbjct: 103 FRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSN 141
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 74.7 bits (182), Expect = 2e-13
Identities = 94/360 (26%), Positives = 137/360 (38%), Gaps = 82/360 (22%)
Query: 63 KYLDCQERKLVYVLPGWPQ---DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISK 119
+YL KL + G Q L +LL+ N++ ++ FS+ LK L L N +
Sbjct: 104 RYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEY 163
Query: 120 IESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ 179
I AF L LT L L N + ++ VF + L LRLY+N +
Sbjct: 164 IPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYEN------------RLTD 211
Query: 180 IPRNRNLGNYAKCESPQEQ--KNKKLRQIKSEQLCNEEEKEQLD-PKPQVSGRPPVIKPE 236
IP +G + + QE + ++ + N ++L +S PP I +
Sbjct: 212 IP----MGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQ 267
Query: 237 VDSTFCHNYVFPIQTLDCKRKELKKVPNNI---PPDIVKLDLSYNKINQLRPKEFEDVHE 293
+ + L LK++ I P++ +L L N I+ L F ++ +
Sbjct: 268 LPQ---------LNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQ 318
Query: 294 LKKLNLSSNGIEFIDPAAFLGLTHLEELDL------------------------------ 323
L+ L LS N I FI P AF GLT L EL L
Sbjct: 319 LQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLR 378
Query: 324 ------------------SNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
NN L+N G+ + L L L L DNPWRCD +I L WL
Sbjct: 379 QLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 438
Score = 66.6 bits (161), Expect = 4e-11
Identities = 44/157 (28%), Positives = 77/157 (49%), Gaps = 5/157 (3%)
Query: 52 LPCDVYTYLHE-KYLDCQERKLVYVLPG---WPQDLLHMLLARNKIRTLKNNMFSKFKKL 107
LP +V++ L + + L ++ ++ PG +L + L N ++ L N+F L
Sbjct: 308 LPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANL 367
Query: 108 KSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC 167
+++ LQ N + ++ F +N L + LQ+NQ++ L +F + L LRLYDNPW C
Sbjct: 368 QNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRC 427
Query: 168 TCEIETLISMLQIPRNR-NLGNYAKCESPQEQKNKKL 203
+I L + L + + R C SP + + L
Sbjct: 428 DSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQSL 464
Score = 47.8 bits (112), Expect = 2e-05
Identities = 29/99 (29%), Positives = 45/99 (45%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAA 311
++C + VP +P + + L + I +L F ++ L L + N + I P A
Sbjct: 37 VECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGA 96
Query: 312 FLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDN 350
F L L L L+NN LQ G+ + L L+ L L N
Sbjct: 97 FRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSN 135
>gi|40217817 slit and trk like 1 protein [Homo sapiens]
Length = 696
Score = 73.9 bits (180), Expect = 3e-13
Identities = 78/323 (24%), Positives = 130/323 (40%), Gaps = 68/323 (21%)
Query: 91 NKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFI 150
NKI++ + F L+ L N + I+ AF LNKL L+L N I L VF
Sbjct: 116 NKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLISTLPANVFQ 175
Query: 151 YTPL------------------------LSYLRLYDNPWHCTCEIETLISMLQ-IPRNRN 185
Y P+ ++ + L DNPW CTC++ +L L+ IP+N
Sbjct: 176 YVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWLENIPKNAL 235
Query: 186 LGNYAKCESPQEQKNKKLRQIKSEQLC------------NEEEKEQLDPKP--------- 224
+G CE+P + K L + + LC ++E P P
Sbjct: 236 IGRVV-CEAPTRLQGKDLNETTEQDLCPLKNRVDSSLPAPPAQEETFAPGPLPTPFKTNG 294
Query: 225 QVSGRPPVIKPEVDSTFCHNYVFPIQ------TLDCKRKEL-KKVP-------NNIPPDI 270
Q P P + N+ I+ T + K L +P ++IP
Sbjct: 295 QEDHATPGSAPNGGTKIPGNWQIKIRPTAAIATGSSRNKPLANSLPCPGGCSCDHIPGSG 354
Query: 271 VKLDLSYNKIN---QLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNS 327
+K++ + ++ L+PK + +++L L N I I + F+ +L LDL NN+
Sbjct: 355 LKMNCNNRNVSSLADLKPK----LSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNN 410
Query: 328 LQNFDYGVLEDLYFLKLLWLRDN 350
+ + ++L L+ L++ N
Sbjct: 411 IATVENNTFKNLLDLRWLYMDSN 433
Score = 50.4 bits (119), Expect = 3e-06
Identities = 37/155 (23%), Positives = 65/155 (41%), Gaps = 24/155 (15%)
Query: 82 DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQI 141
DL + + N + TL F+ + L+ L+++ N I I F + KL L+L +N +
Sbjct: 424 DLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLILPGTFNAMPKLRILILNNNLL 483
Query: 142 KVLTEEVF---------------IYTPLLSYLR---------LYDNPWHCTCEIETLISM 177
+ L +VF +Y P+ L L+ NPW C+C I
Sbjct: 484 RSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQIDLHGNPWECSCTIVPFKQW 543
Query: 178 LQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLC 212
+ + L + KCE+P K + ++++C
Sbjct: 544 AERLGSEVLMSDLKCETPVNFFRKDFMLLSNDEIC 578
Score = 50.1 bits (118), Expect = 4e-06
Identities = 39/142 (27%), Positives = 59/142 (41%), Gaps = 25/142 (17%)
Query: 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLE---------- 319
+ +L ++ NKI R + F + +L+ L N + IDP AF L LE
Sbjct: 108 VKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVLILNDNLIS 167
Query: 320 -------------ELDLSNNSLQNFDY-GVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
LDL N L+ Y VLE + + + L DNPW C ++ L WL
Sbjct: 168 TLPANVFQYVPITHLDLRGNRLKTLPYEEVLEQIPGIAEILLEDNPWDCTCDLLSLKEWL 227
Query: 366 KH-HYNVHFNGLECKTPEEYKG 386
++ N + C+ P +G
Sbjct: 228 ENIPKNALIGRVVCEAPTRLQG 249
Score = 49.3 bits (116), Expect = 7e-06
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 26/125 (20%)
Query: 252 LDCKRKELKKVPNNIPP--DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDP 309
+DC++K + P L L N + +L P EF + + L++ +NG+ I P
Sbjct: 40 VDCEKKGFTSLQRFTAPTSQFYHLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVP 99
Query: 310 AAFLGLTHLEELDLSNNSLQNF------------------------DYGVLEDLYFLKLL 345
AFLGL ++ L ++NN +++F D G +DL L++L
Sbjct: 100 GAFLGLQLVKRLHINNNKIKSFRKQTFLGLDDLEYLQADFNLLRDIDPGAFQDLNKLEVL 159
Query: 346 WLRDN 350
L DN
Sbjct: 160 ILNDN 164
Score = 46.6 bits (109), Expect = 5e-05
Identities = 42/161 (26%), Positives = 66/161 (40%), Gaps = 28/161 (17%)
Query: 252 LDCKRKELKKVPNNIPPDIVKLDLSY---NKINQLRPKEFEDVHELKKLNLSSNGIEFID 308
LD + V NN +++ L Y N ++ L ++F + L+ LN+ N I+ I
Sbjct: 404 LDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAIQLIL 463
Query: 309 PAAFLGLTHLEELDLSNNSLQN--------------------FDY----GVLEDLYFLKL 344
P F + L L L+NN L++ F Y GVL+ L +
Sbjct: 464 PGTFNAMPKLRILILNNNLLRSLPVDVFAGVSLSKLSLHNNYFMYLPVAGVLDQLTSIIQ 523
Query: 345 LWLRDNPWRCDYNIHYLYYWLKH-HYNVHFNGLECKTPEEY 384
+ L NPW C I W + V + L+C+TP +
Sbjct: 524 IDLHGNPWECSCTIVPFKQWAERLGSEVLMSDLKCETPVNF 564
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 2/101 (1%)
Query: 65 LDCQERKLVYVLPGWPQ--DLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIES 122
++C R + + P+ ++ + L NKI +++ + F +K L LDL N I+ +E+
Sbjct: 357 MNCNNRNVSSLADLKPKLSNVQELFLRDNKIHSIRKSHFVDYKNLILLDLGNNNIATVEN 416
Query: 123 EAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
F L L L + N + L+ E F L YL + N
Sbjct: 417 NTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYN 457
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/75 (30%), Positives = 38/75 (50%)
Query: 85 HMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVL 144
H+ L N + L N F+ F SL ++ N + +I AF GL + L + +N+IK
Sbjct: 62 HLFLHGNSLTRLFPNEFANFYNAVSLHMENNGLHEIVPGAFLGLQLVKRLHINNNKIKSF 121
Query: 145 TEEVFIYTPLLSYLR 159
++ F+ L YL+
Sbjct: 122 RKQTFLGLDDLEYLQ 136
Score = 40.4 bits (93), Expect = 0.003
Identities = 23/82 (28%), Positives = 45/82 (54%)
Query: 269 DIVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSL 328
+++ LDL N I + F+++ +L+ L + SN ++ + F GL +LE L++ N++
Sbjct: 400 NLILLDLGNNNIATVENNTFKNLLDLRWLYMDSNYLDTLSREKFAGLQNLEYLNVEYNAI 459
Query: 329 QNFDYGVLEDLYFLKLLWLRDN 350
Q G + L++L L +N
Sbjct: 460 QLILPGTFNAMPKLRILILNNN 481
>gi|30425553 reticulon 4 receptor-like 1 [Homo sapiens]
Length = 441
Score = 73.6 bits (179), Expect = 3e-13
Identities = 52/166 (31%), Positives = 78/166 (46%), Gaps = 6/166 (3%)
Query: 52 LPCDVYTYLHE-KYLDCQERKLVYVLPGWPQDLL---HMLLARNKIRTLKNNMFSKFKKL 107
LP V+ LH +YL Q+ + Y+ DL+ H+ L NK+ +L F L
Sbjct: 140 LPAGVFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNL 199
Query: 108 KSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDNPWHC 167
L L +N++ + +AF L +LTTL L +N + L E L +LRL NPW C
Sbjct: 200 DRLLLHENQLQWVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDC 259
Query: 168 TCEIETLISMLQIPRNRNLGNYAKCESPQEQKNKKLRQIKSEQLCN 213
C +L LQ R R + C SP + + L+ +++E N
Sbjct: 260 GCRARSLWEWLQ--RFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRN 303
Score = 56.6 bits (135), Expect = 4e-08
Identities = 48/180 (26%), Positives = 74/180 (41%), Gaps = 4/180 (2%)
Query: 249 IQTLDCKRKELKKVPNNIPPDIVKLD---LSYNKINQLRPKEFEDVHELKKLNLSSNGIE 305
+Q L + ++ + ++I D+V L L NK+ L P F + L +L L N ++
Sbjct: 151 LQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLLHENQLQ 210
Query: 306 FIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWL 365
++ AF L L L L NNSL L L L+ L L NPW C L+ WL
Sbjct: 211 WVHHKAFHDLRRLTTLFLFNNSLSELQGECLAPLGALEFLRLNGNPWDCGCRARSLWEWL 270
Query: 366 KHHYNVHFNGLECKTPEEYKGWSVGKYIRSYYEECPKDKLPAYPESFDQDTEDDEWEKKH 425
+ + + + C +P G + + C P +S T D K+H
Sbjct: 271 Q-RFRGSSSAVPCVSPGLRHGQDLKLLRAEDFRNCTGPASPHQIKSHTLTTTDRAARKEH 329
Score = 53.9 bits (128), Expect = 3e-07
Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 28/134 (20%)
Query: 242 CHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLDLSYNKINQLRPKEFEDVHELKKLNLSS 301
C Y P+ T+ C+ +P IP D ++ L N+I L+P F + L + S
Sbjct: 29 CVCYPAPM-TVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPA--MVTLWIYS 85
Query: 302 NGIEFIDPAAFLGLTHLEELDLSNN-------------------------SLQNFDYGVL 336
N I +I P+ F G HLEELDL +N L GV
Sbjct: 86 NNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVF 145
Query: 337 EDLYFLKLLWLRDN 350
L+ L+ L+L+DN
Sbjct: 146 GGLHSLQYLYLQDN 159
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 4/96 (4%)
Query: 72 LVYVLPGWPQDLLHM----LLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFG 127
+ Y+ P + +H+ L ++RTL F KL +L L + +S + + F G
Sbjct: 88 ITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAGVFGG 147
Query: 128 LNKLTTLLLQHNQIKVLTEEVFIYTPLLSYLRLYDN 163
L+ L L LQ N I+ L +++F+ LS+L L+ N
Sbjct: 148 LHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGN 183
Score = 38.1 bits (87), Expect = 0.016
Identities = 39/136 (28%), Positives = 50/136 (36%), Gaps = 23/136 (16%)
Query: 51 GLPCDVYTYLHEKYLDCQERKLVYVLPGWPQDLLHMLLARNKIRTLK------------- 97
G P D Y + CQ + G P D + L N+I L+
Sbjct: 24 GCPRDCVCYPAPMTVSCQAHNFAAIPEGIPVDSERVFLQNNRIGLLQPGHFSPAMVTLWI 83
Query: 98 --NNM-------FSKFKKLKSLDLQQN-EISKIESEAFFGLNKLTTLLLQHNQIKVLTEE 147
NN+ F F L+ LDL N ++ + E F GL KL L L + L
Sbjct: 84 YSNNITYIHPSTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSALPAG 143
Query: 148 VFIYTPLLSYLRLYDN 163
VF L YL L DN
Sbjct: 144 VFGGLHSLQYLYLQDN 159
Score = 35.0 bits (79), Expect = 0.14
Identities = 21/63 (33%), Positives = 29/63 (46%)
Query: 288 FEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWL 347
F +H L+ L L N IE++ F+ L +L L L N L + G L L L L
Sbjct: 145 FGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGPGTFRGLVNLDRLLL 204
Query: 348 RDN 350
+N
Sbjct: 205 HEN 207
>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
[Homo sapiens]
Length = 254
Score = 73.2 bits (178), Expect = 5e-13
Identities = 43/134 (32%), Positives = 71/134 (52%), Gaps = 3/134 (2%)
Query: 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQ 329
+V LDLSYN + QL F L KL+L++N + + AF L L+ L+L++N+L+
Sbjct: 66 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 125
Query: 330 NFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGL---ECKTPEEYKG 386
+ L L L+ L L NPW CD + +L+ W++ + + GL +C P E +
Sbjct: 126 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 185
Query: 387 WSVGKYIRSYYEEC 400
S+ + + + EC
Sbjct: 186 ISLRELSEASFSEC 199
Score = 54.3 bits (129), Expect = 2e-07
Identities = 36/129 (27%), Positives = 56/129 (43%), Gaps = 8/129 (6%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L+ + L+ N + L F +L L L N + + +AF L L L L N ++
Sbjct: 66 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 125
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-----IPRNRNLGNYAKCESPQE 197
L+ P L LRL NPW C C+ L S +Q +P+ + +C P E
Sbjct: 126 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL---DEIQCSLPME 182
Query: 198 QKNKKLRQI 206
+ LR++
Sbjct: 183 SRRISLREL 191
>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
sapiens]
Length = 408
Score = 73.2 bits (178), Expect = 5e-13
Identities = 43/134 (32%), Positives = 71/134 (52%), Gaps = 3/134 (2%)
Query: 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQ 329
+V LDLSYN + QL F L KL+L++N + + AF L L+ L+L++N+L+
Sbjct: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
Query: 330 NFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGL---ECKTPEEYKG 386
+ L L L+ L L NPW CD + +L+ W++ + + GL +C P E +
Sbjct: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339
Query: 387 WSVGKYIRSYYEEC 400
S+ + + + EC
Sbjct: 340 ISLRELSEASFSEC 353
Score = 54.3 bits (129), Expect = 2e-07
Identities = 36/129 (27%), Positives = 56/129 (43%), Gaps = 8/129 (6%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L+ + L+ N + L F +L L L N + + +AF L L L L N ++
Sbjct: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-----IPRNRNLGNYAKCESPQE 197
L+ P L LRL NPW C C+ L S +Q +P+ + +C P E
Sbjct: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL---DEIQCSLPME 336
Query: 198 QKNKKLRQI 206
+ LR++
Sbjct: 337 SRRISLREL 345
>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
sapiens]
Length = 408
Score = 73.2 bits (178), Expect = 5e-13
Identities = 43/134 (32%), Positives = 71/134 (52%), Gaps = 3/134 (2%)
Query: 270 IVKLDLSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLTHLEELDLSNNSLQ 329
+V LDLSYN + QL F L KL+L++N + + AF L L+ L+L++N+L+
Sbjct: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
Query: 330 NFDYGVLEDLYFLKLLWLRDNPWRCDYNIHYLYYWLKHHYNVHFNGL---ECKTPEEYKG 386
+ L L L+ L L NPW CD + +L+ W++ + + GL +C P E +
Sbjct: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGLDEIQCSLPMESRR 339
Query: 387 WSVGKYIRSYYEEC 400
S+ + + + EC
Sbjct: 340 ISLRELSEASFSEC 353
Score = 54.3 bits (129), Expect = 2e-07
Identities = 36/129 (27%), Positives = 56/129 (43%), Gaps = 8/129 (6%)
Query: 83 LLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIK 142
L+ + L+ N + L F +L L L N + + +AF L L L L N ++
Sbjct: 220 LVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLR 279
Query: 143 VLTEEVFIYTPLLSYLRLYDNPWHCTCEIETLISMLQ-----IPRNRNLGNYAKCESPQE 197
L+ P L LRL NPW C C+ L S +Q +P+ + +C P E
Sbjct: 280 SLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKGL---DEIQCSLPME 336
Query: 198 QKNKKLRQI 206
+ LR++
Sbjct: 337 SRRISLREL 345
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,479,147
Number of Sequences: 37866
Number of extensions: 909548
Number of successful extensions: 5102
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 191
Number of HSP's successfully gapped in prelim test: 97
Number of HSP's that attempted gapping in prelim test: 3172
Number of HSP's gapped (non-prelim): 1487
length of query: 441
length of database: 18,247,518
effective HSP length: 105
effective length of query: 336
effective length of database: 14,271,588
effective search space: 4795253568
effective search space used: 4795253568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.