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Search of human proteins with 7019381
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|7019381 fibronectin leucine rich transmembrane protein 2
[Homo sapiens]
(660 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 1347 0.0
gi|38202222 fibronectin leucine rich transmembrane protein 3 pre... 582 e-166
gi|7019383 fibronectin leucine rich transmembrane protein 3 prec... 582 e-166
gi|34577057 fibronectin leucine rich transmembrane protein 1 [Ho... 541 e-154
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 141 2e-33
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 132 8e-31
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 132 8e-31
gi|51317373 netrin-G1 ligand [Homo sapiens] 128 2e-29
gi|45505137 podocan [Homo sapiens] 126 6e-29
gi|71040111 fibromodulin precursor [Homo sapiens] 123 5e-28
gi|198041768 synleurin [Homo sapiens] 123 5e-28
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 121 2e-27
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 120 4e-27
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 120 4e-27
gi|88702793 slit-like 2 [Homo sapiens] 120 4e-27
gi|41350214 asporin [Homo sapiens] 117 4e-26
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 116 6e-26
gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo ... 111 2e-24
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 109 9e-24
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 109 9e-24
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 109 9e-24
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 108 2e-23
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 108 2e-23
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 107 5e-23
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 107 5e-23
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 106 6e-23
gi|225579152 insulin-like growth factor binding protein, acid la... 105 1e-22
gi|4826772 insulin-like growth factor binding protein, acid labi... 105 1e-22
gi|19743846 decorin isoform a preproprotein [Homo sapiens] 104 2e-22
gi|4503271 decorin isoform a preproprotein [Homo sapiens] 104 2e-22
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 1347 bits (3487), Expect = 0.0
Identities = 660/660 (100%), Positives = 660/660 (100%)
Query: 1 MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLG 60
MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLG
Sbjct: 1 MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLG 60
Query: 61 IPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENN 120
IPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENN
Sbjct: 61 IPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENN 120
Query: 121 IQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPV 180
IQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPV
Sbjct: 121 IQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPV 180
Query: 181 DLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRN 240
DLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRN
Sbjct: 181 DLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRN 240
Query: 241 SLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLS 300
SLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLS
Sbjct: 241 SLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLS 300
Query: 301 NLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
NLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC
Sbjct: 301 NLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
Query: 361 PTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPP 420
PTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPP
Sbjct: 361 PTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPP 420
Query: 421 ISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSL 480
ISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSL
Sbjct: 421 ISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSL 480
Query: 481 VNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSP 540
VNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSP
Sbjct: 481 VNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSP 540
Query: 541 FLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSIL 600
FLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSIL
Sbjct: 541 FLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSIL 600
Query: 601 EMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT 660
EMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
Sbjct: 601 EMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT 660
>gi|38202222 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 582 bits (1499), Expect = e-166
Identities = 303/649 (46%), Positives = 423/649 (65%), Gaps = 26/649 (4%)
Query: 24 LGLYSQVSKLL----ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAG 79
+GL+ QV+ L +CPSVCRCD F+YCN+R LTS+P GIPE T LYL NNQINNAG
Sbjct: 15 IGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74
Query: 80 FPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELH 139
P++L N+ V +YLY N LDEFP NLPK V+ LHLQENNI+TI+ +L+++ LEELH
Sbjct: 75 IPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELH 134
Query: 140 LDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMA 199
LDDNS+S V +E+GAFR++ L+LLFLS+NHLS++P GLP ++ELR+D+NRI+ IS +
Sbjct: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194
Query: 200 FQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYL 259
Q LTSL+RL++DGNLL N G+ + F +L L E S+VRNSL+ P +LPGT+L +LYL
Sbjct: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYL 254
Query: 260 QDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIK 319
QDN IN +P AFS LR+L RLD+SNN L L QG+FD+L N+ QL RNNPW+C C +K
Sbjct: 255 QDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMK 314
Query: 320 WVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASP 379
WV +WL+ +P +NVRG MCQ PE+VRGMA+++LN L C + ST
Sbjct: 315 WVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKD--------SGIVSTIQI 366
Query: 380 TTQPPTLSIPNPSRSYTPPTPTTSKLPTIPD---WDGRERVTPPISERIQLSIHFVNDTS 436
TT P P + P P T K P I + + P + I +++ V +
Sbjct: 367 TTAIPNTVYPAQGQW---PAPVT-KQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDT 422
Query: 437 IQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPL 496
I +SW + A +L+W+K+GHS G + E IV+GE+ + LEP S Y++C+VP+
Sbjct: 423 IHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPM 482
Query: 497 DAFNYRAVEDT-ICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFL-LAGLIGGAVIFV 554
+ N ++T +C E T + N + T + ++ + +P L LA +IGGAV V
Sbjct: 483 ETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYK--NPNLPLAAIIGGAVALV 540
Query: 555 LVVLLSVFCWHMHKKGRYTSQKWKYNRG-RRKDDYCEAGTKKDNSILEMTETSFQIVSLN 613
+ LL++ CW++H+ G S+ Y++G RRKDDY EAGTKKDNSILE+ ETSFQ++ ++
Sbjct: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600
Query: 614 NDQLLKGDFRLQPIYTPNGGINYTDCH--IPNNMRYCNSSVPDLEHCHT 660
N+ + K +F + I+ PNG Y + H +N Y +S +PD +H H+
Sbjct: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649
>gi|7019383 fibronectin leucine rich transmembrane protein 3
precursor [Homo sapiens]
Length = 649
Score = 582 bits (1499), Expect = e-166
Identities = 303/649 (46%), Positives = 423/649 (65%), Gaps = 26/649 (4%)
Query: 24 LGLYSQVSKLL----ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAG 79
+GL+ QV+ L +CPSVCRCD F+YCN+R LTS+P GIPE T LYL NNQINNAG
Sbjct: 15 IGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAG 74
Query: 80 FPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELH 139
P++L N+ V +YLY N LDEFP NLPK V+ LHLQENNI+TI+ +L+++ LEELH
Sbjct: 75 IPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELH 134
Query: 140 LDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMA 199
LDDNS+S V +E+GAFR++ L+LLFLS+NHLS++P GLP ++ELR+D+NRI+ IS +
Sbjct: 135 LDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPS 194
Query: 200 FQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYL 259
Q LTSL+RL++DGNLL N G+ + F +L L E S+VRNSL+ P +LPGT+L +LYL
Sbjct: 195 LQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYL 254
Query: 260 QDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIK 319
QDN IN +P AFS LR+L RLD+SNN L L QG+FD+L N+ QL RNNPW+C C +K
Sbjct: 255 QDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMK 314
Query: 320 WVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASP 379
WV +WL+ +P +NVRG MCQ PE+VRGMA+++LN L C + ST
Sbjct: 315 WVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKD--------SGIVSTIQI 366
Query: 380 TTQPPTLSIPNPSRSYTPPTPTTSKLPTIPD---WDGRERVTPPISERIQLSIHFVNDTS 436
TT P P + P P T K P I + + P + I +++ V +
Sbjct: 367 TTAIPNTVYPAQGQW---PAPVT-KQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDT 422
Query: 437 IQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPL 496
I +SW + A +L+W+K+GHS G + E IV+GE+ + LEP S Y++C+VP+
Sbjct: 423 IHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPM 482
Query: 497 DAFNYRAVEDT-ICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFL-LAGLIGGAVIFV 554
+ N ++T +C E T + N + T + ++ + +P L LA +IGGAV V
Sbjct: 483 ETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYK--NPNLPLAAIIGGAVALV 540
Query: 555 LVVLLSVFCWHMHKKGRYTSQKWKYNRG-RRKDDYCEAGTKKDNSILEMTETSFQIVSLN 613
+ LL++ CW++H+ G S+ Y++G RRKDDY EAGTKKDNSILE+ ETSFQ++ ++
Sbjct: 541 TIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPIS 600
Query: 614 NDQLLKGDFRLQPIYTPNGGINYTDCH--IPNNMRYCNSSVPDLEHCHT 660
N+ + K +F + I+ PNG Y + H +N Y +S +PD +H H+
Sbjct: 601 NEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS 649
>gi|34577057 fibronectin leucine rich transmembrane protein 1 [Homo
sapiens]
Length = 674
Score = 541 bits (1393), Expect = e-154
Identities = 290/669 (43%), Positives = 416/669 (62%), Gaps = 49/669 (7%)
Query: 16 LKSWLIISLGLYSQVSKLL---ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHN 72
L+ WL + GL + +++++ CPSVCRCD F+YCN+R LTS+P IP+ T LYL N
Sbjct: 31 LRDWLFLCYGLIAFLTEVIDSTTCPSVCRCDNGFIYCNDRGLTSIPADIPDDATTLYLQN 90
Query: 73 NQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQL 132
NQINNAG P +L +V +YLY N LDEFP+NLP+++R LHLQ+NN++TI+R +LA++
Sbjct: 91 NQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARI 150
Query: 133 LKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRI 192
LE+LHLDDNS+STV +E+ AF ++ LKLLFLS+NHLSS+P GLP L+ELR+D+NRI
Sbjct: 151 PLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRI 210
Query: 193 AVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT 252
+ I AF+ L SL RL++DGNLL N+ IA+ TFS L L E S+VRNSL+ PP +LP
Sbjct: 211 STIPLHAFKGLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSA 270
Query: 253 HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPW 312
HL +LYLQDN I+HIP + +R+LERLD+SNN L L +G+FD+L NL QL RNNPW
Sbjct: 271 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNPW 330
Query: 313 FCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTP-----GL 367
FC C++ W+ +W+K + +NVRG MCQGPE+VRGMA++++ + C T P
Sbjct: 331 FCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGMAIKDITSEMDECFETGPQGGVANA 390
Query: 368 PLFTPAPSTASPTT----------QPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERV 417
T A + AS TT + P L +P+ + Y T DG
Sbjct: 391 AAKTTASNHASATTPQGSLFTLKAKRPGLRLPDSNIDYPMAT-----------GDG---- 435
Query: 418 TPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQH 477
++ + + + + SI+++W + +++L+W+++GHS G + E +V G+K
Sbjct: 436 ----AKTLAIHVKALTADSIRITWKATLPASSFRLSWLRLGHSPAVGSITETLVQGDKTE 491
Query: 478 LSLVNLEPRSTYRICLVPLDAFN-YRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHS 536
L LEP+STY IC+V ++ N Y A E +C++A T SY G T + EQ
Sbjct: 492 YLLTALEPKSTYIICMVTMETSNAYVADETPVCAKAETADSY---GPTTTLNQEQNAGPM 548
Query: 537 MGSPFLLAGLIGGAVIFV-LVVLLSVFCWHMHKKGRYTSQKWKYNRG-RRKDDYCEAGTK 594
P LAG+IGGAV V L ++L CW++H+ G +++ YNRG R+KDDY E+GTK
Sbjct: 549 ASLP--LAGIIGGAVALVFLFLVLGAICWYVHQAGELLTRERAYNRGSRKKDDYMESGTK 606
Query: 595 KDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCH---IPNNMRYCNSS 651
KDNSILE+ Q++ + N K ++ + I+ NG H Y +
Sbjct: 607 KDNSILEIRGPGLQMLPI-NPYRAKEEYVVHTIFPSNGSSLCKATHTIGYGTTRGYRDGG 665
Query: 652 VPDLEHCHT 660
+PD+++ +T
Sbjct: 666 IPDIDYSYT 674
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 141 bits (356), Expect = 2e-33
Identities = 119/430 (27%), Positives = 175/430 (40%), Gaps = 105/430 (24%)
Query: 36 CPSVCRCDRNFVYCNERSLTSVPLGIPE------------------------GVTVLYLH 71
CP C C V+C++ L +VPL IP +T +
Sbjct: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
Query: 72 NNQINN------AGFPAE-----------------LHNVQSVHTVYLYGNQLDEFPMNLP 108
N Q+ G P N+ S+ + L N L+ P L
Sbjct: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
Query: 109 KNVRVL---HLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLF 165
+++ L HLQ N +Q + R L L+ L+L N ++ + E F SL+ L
Sbjct: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEE--LFHPLTSLQTLK 199
Query: 166 LSKNHLSSVPVGL---PVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTN---- 218
LS N LS +P G+ LQEL +D N I+ + F L LERL + N +T+
Sbjct: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLS 259
Query: 219 ------------------------------------------KGIAEGTFSHLTKLKEFS 236
+ +AEGTF+HL+ L+
Sbjct: 260 IFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLM 319
Query: 237 IVRNSLSHPPPDL--PGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQG 294
+ N+++H P + L++LYL N + + F NL KLE L +S NQL L +G
Sbjct: 320 LSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEG 379
Query: 295 VFDNLSNLKQLTARNNPWFCDCSIKWVTEWL-KYIPSSLNVRGFMCQGPEQVRGMAVREL 353
+FD NL L NPW CDC + ++ WL +Y LN++ + C GP ++G V L
Sbjct: 380 IFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY-CAGPAYLKGQVVPAL 438
Query: 354 NMNLLSCPTT 363
N L CP T
Sbjct: 439 NEKQLVCPVT 448
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 132 bits (333), Expect = 8e-31
Identities = 117/425 (27%), Positives = 185/425 (43%), Gaps = 74/425 (17%)
Query: 54 LTSVPLGIPEGVTVL---YLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFP------ 104
L +P+G+ +G+ L L +NQ+ PA ++ + L+GN L+ P
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDGAFDH 177
Query: 105 ------MNLPKN---------------VRVLHLQENNIQTISRAALAQLLKLEELHLDDN 143
+NL KN ++VL L EN + I L+ L+EL L N
Sbjct: 178 LVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 237
Query: 144 SISTVGVEDGAFREAISLKLLFLSKNHLSSVP---------------------------V 176
I + G F +L+ L+LS NH+S +P
Sbjct: 238 QIGLLS--PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 295
Query: 177 GLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFS 236
G +L+EL + +N I+ + D F NL L+ LI+ N ++ I+ G F+ LT+L+E S
Sbjct: 296 GPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF--ISPGAFNGLTELRELS 353
Query: 237 IVRNSLSHPPPDLPGT------HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM 290
+ N+L DL G +L + LQ+N++ +P F+N+ L + + NNQL
Sbjct: 354 LHTNALQ----DLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLEN 409
Query: 291 LTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGF-MCQGPEQVRGMA 349
L G+FD+L L +L +NPW CD I + WL L +C P VRG +
Sbjct: 410 LPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQS 469
Query: 350 VRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIP 409
+ +N+N+ P +P + P + P T S+ + + T P + L TI
Sbjct: 470 LIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSV-SSTTELTSPVEDYTDLTTIQ 528
Query: 410 DWDGR 414
D R
Sbjct: 529 VTDDR 533
Score = 97.1 bits (240), Expect = 5e-20
Identities = 67/221 (30%), Positives = 112/221 (50%), Gaps = 13/221 (5%)
Query: 97 GNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFR 156
G ++ P LP N L + +I ++ + + L L ++ N +S + GAFR
Sbjct: 47 GARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRI--TPGAFR 104
Query: 157 EAISLKLLFLSKNHLSSVPVGL---PVDLQELRVDENRIAVISDMAFQNLTSLERLIVDG 213
SL+ L L+ N L +P+GL L+ L + N++ I F ++L+ L + G
Sbjct: 105 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 164
Query: 214 NLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP----DLPGTHLIRLYLQDNQINHIPL 269
N L + I +G F HL L + ++ +NSL+H P L ++RLY +N++ IP+
Sbjct: 165 NHL--EYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLY--ENRLTDIPM 220
Query: 270 TAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNN 310
F L L+ L + NQ+ +L+ G+F N NL++L NN
Sbjct: 221 GTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN 261
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 132 bits (333), Expect = 8e-31
Identities = 117/425 (27%), Positives = 185/425 (43%), Gaps = 74/425 (17%)
Query: 54 LTSVPLGIPEGVTVL---YLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFP------ 104
L +P+G+ +G+ L L +NQ+ PA ++ + L+GN L+ P
Sbjct: 113 LQVLPIGLFQGLDSLESLLLSSNQLLQIQ-PAHFSQCSNLKELQLHGNHLEYIPDGAFDH 171
Query: 105 ------MNLPKN---------------VRVLHLQENNIQTISRAALAQLLKLEELHLDDN 143
+NL KN ++VL L EN + I L+ L+EL L N
Sbjct: 172 LVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQN 231
Query: 144 SISTVGVEDGAFREAISLKLLFLSKNHLSSVP---------------------------V 176
I + G F +L+ L+LS NH+S +P
Sbjct: 232 QIGLLS--PGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIF 289
Query: 177 GLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFS 236
G +L+EL + +N I+ + D F NL L+ LI+ N ++ I+ G F+ LT+L+E S
Sbjct: 290 GPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISF--ISPGAFNGLTELRELS 347
Query: 237 IVRNSLSHPPPDLPGT------HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM 290
+ N+L DL G +L + LQ+N++ +P F+N+ L + + NNQL
Sbjct: 348 LHTNALQ----DLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLEN 403
Query: 291 LTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGF-MCQGPEQVRGMA 349
L G+FD+L L +L +NPW CD I + WL L +C P VRG +
Sbjct: 404 LPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPRLGTDTVPVCFSPANVRGQS 463
Query: 350 VRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIP 409
+ +N+N+ P +P + P + P T S+ + + T P + L TI
Sbjct: 464 LIIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTSV-SSTTELTSPVEDYTDLTTIQ 522
Query: 410 DWDGR 414
D R
Sbjct: 523 VTDDR 527
Score = 97.1 bits (240), Expect = 5e-20
Identities = 67/221 (30%), Positives = 112/221 (50%), Gaps = 13/221 (5%)
Query: 97 GNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFR 156
G ++ P LP N L + +I ++ + + L L ++ N +S + GAFR
Sbjct: 41 GARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRI--TPGAFR 98
Query: 157 EAISLKLLFLSKNHLSSVPVGL---PVDLQELRVDENRIAVISDMAFQNLTSLERLIVDG 213
SL+ L L+ N L +P+GL L+ L + N++ I F ++L+ L + G
Sbjct: 99 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 158
Query: 214 NLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP----DLPGTHLIRLYLQDNQINHIPL 269
N L + I +G F HL L + ++ +NSL+H P L ++RLY +N++ IP+
Sbjct: 159 NHL--EYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLY--ENRLTDIPM 214
Query: 270 TAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNN 310
F L L+ L + NQ+ +L+ G+F N NL++L NN
Sbjct: 215 GTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNN 255
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 128 bits (321), Expect = 2e-29
Identities = 105/356 (29%), Positives = 166/356 (46%), Gaps = 50/356 (14%)
Query: 20 LIISLGLYSQVSKLLACPSVCRCDRNF--VYCNERSLTSVPLGIPEGVTVLYLHNNQINN 77
L + L + + + + CPSVC C F V C ++L VP GI +L
Sbjct: 31 LALQLLVVAGLVRAQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLN-------- 82
Query: 78 AGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVR---VLHLQENNIQTISRAALAQLLK 134
L+ NQ+ +N K++R +L L N+I+TI A L
Sbjct: 83 -----------------LHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLAN 125
Query: 135 LEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPV----GLP----VDLQELR 186
L L L DN ++T+ +GAF LK L+L N + S+P +P +DL EL+
Sbjct: 126 LNTLELFDNRLTTI--PNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELK 183
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSH-P 245
R++ IS+ AF+ L++L L NL + L KL E + N LS
Sbjct: 184 ----RLSYISEGAFEGLSNLRYL----NLAMCNLREIPNLTPLIKLDELDLSGNHLSAIR 235
Query: 246 PPDLPGT-HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQ 304
P G HL +L++ +QI I AF NL+ L +++++N L +L +F L +L++
Sbjct: 236 PGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLER 295
Query: 305 LTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
+ +NPW C+C I W++ W+K + S C P ++G + EL+ N +C
Sbjct: 296 IHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTC 351
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 126 bits (317), Expect = 6e-29
Identities = 89/295 (30%), Positives = 140/295 (47%), Gaps = 28/295 (9%)
Query: 50 NERSLTSVPLGIPEGVTVLYL------------------------HNNQINNAGF-PAEL 84
+ +L+ VP G+P + +L+L H+NQ+ G P
Sbjct: 344 SSNNLSRVPAGLPRSLVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAF 403
Query: 85 HNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNS 144
++ +HTV+LY N L+ P LP+ VR L + N I I R A LEEL+L N
Sbjct: 404 QGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNR 463
Query: 145 ISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLT 204
I++ V AFR+ L+ L LS N L ++P GLP ++ L+V N +A ++ A +
Sbjct: 464 ITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMA 523
Query: 205 SLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQI 264
L L + N L ++ + + L L+ I N L+ P LP + L LYLQ+N+I
Sbjct: 524 QLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPES-LEYLYLQNNKI 582
Query: 265 NHIPLTAFSNLRKLERLDISNNQLRM--LTQGVFDNLSNLKQLTARNNPWFCDCS 317
+ +P AF + L+ + + N+L + + F L +L+ L N F D S
Sbjct: 583 SAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGNLEFGDIS 637
Score = 116 bits (291), Expect = 6e-26
Identities = 80/246 (32%), Positives = 124/246 (50%), Gaps = 4/246 (1%)
Query: 68 LYLHNNQINNAGFPAELHNVQS-VHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
+YLHNN++ +AG P + N S V + L N L P +LP + LHL+ N ++ I
Sbjct: 244 VYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLHLKNNKLEKIPP 303
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
A ++L L EL+L +N ++ G+++ F + SL+ L LS N+LS VP GLP L L
Sbjct: 304 GAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH 363
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+++N I + + SLE L++ N L +GI F L +L + N+L P
Sbjct: 364 LEKNAIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVP 423
Query: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLR--MLTQGVFDNLSNLKQ 304
LP + L + NQI I F+ LE L++S N++ + + F L L+
Sbjct: 424 SGLP-RRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRS 482
Query: 305 LTARNN 310
L N
Sbjct: 483 LDLSGN 488
Score = 114 bits (285), Expect = 3e-25
Identities = 88/308 (28%), Positives = 136/308 (44%), Gaps = 35/308 (11%)
Query: 34 LACPSVCRCDRNFVY-CNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHT 92
++CP C C + V C L P +PE L L NNQ+ +P EL + + T
Sbjct: 114 VSCPRDCACSQEGVVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKI-YPEELSRLHRLET 172
Query: 93 V--------------------------YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
+ YL N+L P LP + + N + I
Sbjct: 173 LNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYG 232
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
Q L ++L +N ++ G+ D F + ++++L LS N L VP LP L +L
Sbjct: 233 LTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALYKLH 292
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+ N++ I AF L+SL L + N LT++G+ TF L+ L+ + N+LS P
Sbjct: 293 LKNNKLEKIPPGAFSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVP 352
Query: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGV----FDNLSNL 302
LP + L+ L+L+ N I + + +R LE L + +NQLR QG+ F L L
Sbjct: 353 AGLPRS-LVLLHLEKNAIRSVDANVLTPIRSLEYLLLHSNQLR--EQGIHPLAFQGLKRL 409
Query: 303 KQLTARNN 310
+ NN
Sbjct: 410 HTVHLYNN 417
Score = 93.6 bits (231), Expect = 5e-19
Identities = 74/261 (28%), Positives = 117/261 (44%), Gaps = 26/261 (9%)
Query: 68 LYLHNNQINNAGFPAELH-NVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
LYL NN + + G E + S+ + L N L P LP+++ +LHL++N I+++
Sbjct: 315 LYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLEKNAIRSVDA 374
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
L + LE L L N + G+ AF+ L + L N L VP GLP ++ L
Sbjct: 375 NVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLM 434
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+ N+I I F LE L + N +T+ + F L L+ + N L P
Sbjct: 435 ILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLP 494
Query: 247 PDLP-GTHLIR----------------------LYLQDNQINHIPL--TAFSNLRKLERL 281
P LP H+++ LYL N++ L A+ +L L+ L
Sbjct: 495 PGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLL 554
Query: 282 DISNNQLRMLTQGVFDNLSNL 302
DI+ NQL + +G+ ++L L
Sbjct: 555 DIAGNQLTEIPEGLPESLEYL 575
Score = 86.7 bits (213), Expect = 6e-17
Identities = 59/219 (26%), Positives = 103/219 (47%), Gaps = 25/219 (11%)
Query: 47 VYCNERSLTSVPLGIPEGVTVLYLHNNQINNAG--------FPAELH------------- 85
V+ +L VP G+P V L + +NQI G F EL+
Sbjct: 412 VHLYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHR 471
Query: 86 ----NVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLD 141
++ + ++ L GN+L P LP+NV VL ++ N + ++R AL + +L EL+L
Sbjct: 472 DAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLT 531
Query: 142 DNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQ 201
N + + + A+ + L+LL ++ N L+ +P GLP L+ L + N+I+ + AF
Sbjct: 532 SNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVPANAFD 591
Query: 202 NLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRN 240
+ +L+ + + N L + + F L L+ I N
Sbjct: 592 STPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|71040111 fibromodulin precursor [Homo sapiens]
Length = 376
Score = 123 bits (309), Expect = 5e-28
Identities = 95/288 (32%), Positives = 133/288 (46%), Gaps = 41/288 (14%)
Query: 36 CPSVCRCDRNF---VYCNERSLTSVPLGIPEGVTVLYLHNNQI---------NNAGFP-A 82
CP C C NF +YC+ R+L +P +P + +Y NNQI N G
Sbjct: 76 CPQECDCPPNFPTAMYCDNRNLKYLPF-VPSRMKYVYFQNNQITSIQEGVFDNATGLLWI 134
Query: 83 ELHNVQ---------------SVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRA 127
LH Q + +YL N L P LP+++R LHL N I +
Sbjct: 135 ALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGPLPRSLRELHLDHNQISRVPNN 194
Query: 128 ALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRV 187
AL L L L+L N I VG + R SL LL LS NHL VP GLP L++L +
Sbjct: 195 ALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDLSYNHLRKVPDGLPSALEQLYM 251
Query: 188 DENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP 247
+ N + + D F+ L + + N LTN G+A TF+ + L E + N L PP
Sbjct: 252 EHNNVYTVPDSYFRGAPKLLYVRLSHNSLTNNGLASNTFNS-SSLLELDLSYNQLQKIPP 310
Query: 248 DLPGTHLIRLYLQDNQINHIPLTAFS------NLRKLERLDISNNQLR 289
T+L LYLQ N+IN +++F N KL+ L + N+++
Sbjct: 311 --VNTNLENLYLQGNRINEFSISSFCTVVDVVNFSKLQVLRLDGNEIK 356
Score = 70.9 bits (172), Expect = 4e-12
Identities = 62/248 (25%), Positives = 106/248 (42%), Gaps = 6/248 (2%)
Query: 58 PLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQ 117
P G+ EG Y + + P E + T N+ ++ +P ++ ++ Q
Sbjct: 54 PYGVDEGPAYTYGSPSPPDPRDCPQECDCPPNFPTAMYCDNRNLKYLPFVPSRMKYVYFQ 113
Query: 118 ENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVG 177
N I +I L + L N I++ V F + L+ L+L N+L+ +P
Sbjct: 114 NNQITSIQEGVFDNATGLLWIALHGNQITSDKVGRKVFSKLRHLERLYLDHNNLTRMPGP 173
Query: 178 LPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSI 237
LP L+EL +D N+I+ + + A + L +L L + N + G + L L +
Sbjct: 174 LPRSLRELHLDHNQISRVPNNALEGLENLTALYLQHNEIQEVG---SSMRGLRSLILLDL 230
Query: 238 VRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFD 297
N L P LP L +LY++ N + +P + F KL + +S+N L G+
Sbjct: 231 SYNHLRKVPDGLPSA-LEQLYMEHNNVYTVPDSYFRGAPKLLYVRLSHNSL--TNNGLAS 287
Query: 298 NLSNLKQL 305
N N L
Sbjct: 288 NTFNSSSL 295
Score = 30.0 bits (66), Expect = 7.1
Identities = 15/65 (23%), Positives = 30/65 (46%), Gaps = 8/65 (12%)
Query: 246 PPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQL 305
PP+ P +Y + + ++P +++ + NNQ+ + +GVFDN + L +
Sbjct: 83 PPNFPTA----MYCDNRNLKYLPFVP----SRMKYVYFQNNQITSIQEGVFDNATGLLWI 134
Query: 306 TARNN 310
N
Sbjct: 135 ALHGN 139
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 123 bits (309), Expect = 5e-28
Identities = 111/405 (27%), Positives = 178/405 (43%), Gaps = 63/405 (15%)
Query: 16 LKSWLIISLGLYSQVSK-LLACPSVCR-CDRNFVYCNERSLTSVPLGIPEGVTVLYLHNN 73
L+ +L+++ L + K +L C SVC+ C + C L+S+P PE LYL N
Sbjct: 11 LRLFLVVTCYLLLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGN 70
Query: 74 QIN--NAGFPAELHN-------------------VQSVHTVYLYGN-----QLDEFPMNL 107
I+ N LH+ VQ H +L+ N +LD
Sbjct: 71 NISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKG 130
Query: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG------------------ 149
N+R L+LQ N + + R L+ ++ L+L N ++ +G
Sbjct: 131 LLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNN 190
Query: 150 ----VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR---VDENRIAVISDMAFQN 202
+ + F+ +L L+L N+L+ VP L+ LR + N I I AF+
Sbjct: 191 NILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKG 250
Query: 203 LTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT--HLIRLYLQ 260
L +LE L++ + + N + FS + LK + N L + D +LI L L
Sbjct: 251 LANLEYLLLKNSRIRN--VTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLD 308
Query: 261 DNQINHIPLTAFSNL-RKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIK 319
N+I I F N+ L+ L++S N L L V LS+L L A +NPW C+C +
Sbjct: 309 RNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLL 368
Query: 320 WVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTT 364
+ +WL +LN+ CQ P +RG A+R + N+ +C T++
Sbjct: 369 GLRDWLASSAITLNI---YCQNPPSMRGRALRYI--NITNCVTSS 408
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 121 bits (304), Expect = 2e-27
Identities = 96/289 (33%), Positives = 134/289 (46%), Gaps = 32/289 (11%)
Query: 100 LDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAI 159
L E P +P N R L+L ENNIQ I L LE L L NSI + V GAF
Sbjct: 66 LSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEV--GAFNGLA 123
Query: 160 SLKLLFLSKNHLSSVPVGLPVDLQELR---VDENRIAVISDMAFQNLTSLERLIVDGNLL 216
SL L L N L+ +P G L +LR + N I I AF + SL RL + G L
Sbjct: 124 SLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDL-GELK 182
Query: 217 TNKGIAEGTFSHLTKLKEFSI-------------------VRNSLSHPPPDLPGTH---- 253
+ I+EG F L LK ++ + S +H P PG+
Sbjct: 183 KLEYISEGAFEGLFNLKYLNLGMCNIKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLS 242
Query: 254 -LIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPW 312
L +L++ ++Q++ I AF L L L++++N L L +F L L +L +NPW
Sbjct: 243 SLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNPW 302
Query: 313 FCDCSIKWVTEWLK-YIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
CDC I W+ WL+ YIP++ G C P +RG + E++ C
Sbjct: 303 NCDCDILWLAWWLREYIPTNSTCCG-RCHAPMHMRGRYLVEVDQASFQC 350
Score = 60.8 bits (146), Expect = 4e-09
Identities = 46/142 (32%), Positives = 73/142 (51%), Gaps = 5/142 (3%)
Query: 167 SKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTF 226
++ LS VP G+P + + L + EN I +I F++L LE L + N + + I G F
Sbjct: 62 TRRGLSEVPQGIPSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSI--RQIEVGAF 119
Query: 227 SHLTKLKEFSIVRNSLSHPPPDLPG--THLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
+ L L + N L+ P + L L+L++N I IP AF+ + L RLD+
Sbjct: 120 NGLASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLG 179
Query: 285 N-NQLRMLTQGVFDNLSNLKQL 305
+L +++G F+ L NLK L
Sbjct: 180 ELKKLEYISEGAFEGLFNLKYL 201
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 120 bits (301), Expect = 4e-27
Identities = 83/262 (31%), Positives = 123/262 (46%), Gaps = 26/262 (9%)
Query: 68 LYLHNNQINNAGFPAE-LHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
+YLHNNQ++NAG P + +++ T+ L NQL P +LP ++ LHLQ N I + R
Sbjct: 172 VYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPR 231
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
AL++ +L EL+L N ++ G++ F + SL+ L LS N L++VP GLP L L
Sbjct: 232 GALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH 291
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+ NRI + L L++ N L + G+ G L L + N L P
Sbjct: 292 LGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVP 351
Query: 247 PDLPG---------THLIRLYLQD-------NQIN---------HIPLTAFSNLRKLERL 281
P LP H+ L +D ++N + AF LR L L
Sbjct: 352 PALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSL 411
Query: 282 DISNNQLRMLTQGVFDNLSNLK 303
D++ NQL L G+ L L+
Sbjct: 412 DLAGNQLTRLPMGLPTGLRTLQ 433
Score = 107 bits (266), Expect = 5e-23
Identities = 82/280 (29%), Positives = 122/280 (43%), Gaps = 27/280 (9%)
Query: 35 ACPSVCRCDR-NFVYCNERSLTSVPLGIPE------------------------GVTVLY 69
ACP C C R + V C+ L P I G+ L
Sbjct: 43 ACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLN 102
Query: 70 LHNNQINNAGFPAE-LHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAA 128
LHNN I++ G P E ++ + + + N+L P LP+++RV L N + I
Sbjct: 103 LHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLT 162
Query: 129 LAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVD 188
+ L ++L +N +S G+ AFR + ++ L LS N LS +P LP L+ L +
Sbjct: 163 FGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQ 222
Query: 189 ENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPD 248
N I+ + A T L L + N LT+ G+ TFS L L+ + N L+ P
Sbjct: 223 NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAG 282
Query: 249 LPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288
LP T L L+L N+I + R L L + +NQL
Sbjct: 283 LPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQL 321
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/232 (31%), Positives = 108/232 (46%), Gaps = 27/232 (11%)
Query: 90 VHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG 149
V TV G L FP N+ + + L LQ N +Q + L++L L L+L +N IS+ G
Sbjct: 53 VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 112
Query: 150 VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERL 209
+ D AF L+ L ++ N LS P LP L+ + N++ I + F +L +
Sbjct: 113 LPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSV 172
Query: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIP- 268
+ N L+N G+ F + S+ N LS+ PP LP + L RL+LQ+N I+ +P
Sbjct: 173 YLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPS-LERLHLQNNLISKVPR 231
Query: 269 -------------------------LTAFSNLRKLERLDISNNQLRMLTQGV 295
T FS L LE LD+S+NQL + G+
Sbjct: 232 GALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 283
Score = 96.7 bits (239), Expect = 6e-20
Identities = 61/198 (30%), Positives = 102/198 (51%), Gaps = 2/198 (1%)
Query: 52 RSLTSVPLGIPEGVTVLYLHNNQINNAGFPA-ELHNVQSVHTVYLYGNQLDEFPMNLPKN 110
R + + L G+ L L +NQ+ ++G PA L ++ +HT++LYGN LD P LP+
Sbjct: 298 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 357
Query: 111 VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNH 170
+R L L N++ + L L EL+L N +++ V AFR +L+ L L+ N
Sbjct: 358 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ 417
Query: 171 LSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLT 230
L+ +P+GLP L+ L++ N++ ++ L L L + N L I GT+ L
Sbjct: 418 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 477
Query: 231 KLK-EFSIVRNSLSHPPP 247
L+ +V +++ PP
Sbjct: 478 ALQVRHRLVSHTVPRAPP 495
Score = 93.6 bits (231), Expect = 5e-19
Identities = 68/224 (30%), Positives = 103/224 (45%), Gaps = 2/224 (0%)
Query: 68 LYLHNNQINNAGFPAELHN-VQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
LYL +NQ+ ++G A + + S+ + L NQL P LP+ + +LHL N I+ +
Sbjct: 243 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 302
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
A L L L L N + + G+ GA R L L L N L VP LP L+ L
Sbjct: 303 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 362
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+ N +A + L L + N L + + F L L+ + N L+ P
Sbjct: 363 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLP 422
Query: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM 290
LP T L L LQ NQ+ + + L +L L +++N+LR+
Sbjct: 423 MGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 465
Score = 36.6 bits (83), Expect = 0.076
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 20/149 (13%)
Query: 257 LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM--LTQGVFDNLSNLKQLTARNNPWFC 314
L LQ+NQ+ +P S L L L++ NN + L F++L+ L+ L +N
Sbjct: 77 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNK--- 133
Query: 315 DCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVREL----NMNLLSCPTTTPGLPLF 370
++ +++P SL V ++ + E ++ L + + GLP
Sbjct: 134 ------LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLP-- 185
Query: 371 TPAPSTASPTTQPPTLSIPNPSRSYTPPT 399
P + TLS+ N SY PP+
Sbjct: 186 ---PDAFRGSEAIATLSLSNNQLSYLPPS 211
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 120 bits (301), Expect = 4e-27
Identities = 83/262 (31%), Positives = 123/262 (46%), Gaps = 26/262 (9%)
Query: 68 LYLHNNQINNAGFPAE-LHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
+YLHNNQ++NAG P + +++ T+ L NQL P +LP ++ LHLQ N I + R
Sbjct: 174 VYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPR 233
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
AL++ +L EL+L N ++ G++ F + SL+ L LS N L++VP GLP L L
Sbjct: 234 GALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH 293
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+ NRI + L L++ N L + G+ G L L + N L P
Sbjct: 294 LGRNRIRQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVP 353
Query: 247 PDLPG---------THLIRLYLQD-------NQIN---------HIPLTAFSNLRKLERL 281
P LP H+ L +D ++N + AF LR L L
Sbjct: 354 PALPRRLRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSL 413
Query: 282 DISNNQLRMLTQGVFDNLSNLK 303
D++ NQL L G+ L L+
Sbjct: 414 DLAGNQLTRLPMGLPTGLRTLQ 435
Score = 107 bits (266), Expect = 5e-23
Identities = 82/280 (29%), Positives = 122/280 (43%), Gaps = 27/280 (9%)
Query: 35 ACPSVCRCDR-NFVYCNERSLTSVPLGIPE------------------------GVTVLY 69
ACP C C R + V C+ L P I G+ L
Sbjct: 45 ACPLRCSCPRVDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLN 104
Query: 70 LHNNQINNAGFPAE-LHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAA 128
LHNN I++ G P E ++ + + + N+L P LP+++RV L N + I
Sbjct: 105 LHNNLISSEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLT 164
Query: 129 LAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVD 188
+ L ++L +N +S G+ AFR + ++ L LS N LS +P LP L+ L +
Sbjct: 165 FGEKPALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQ 224
Query: 189 ENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPD 248
N I+ + A T L L + N LT+ G+ TFS L L+ + N L+ P
Sbjct: 225 NNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAG 284
Query: 249 LPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQL 288
LP T L L+L N+I + R L L + +NQL
Sbjct: 285 LPRT-LAILHLGRNRIRQVEAARLHGARGLRYLLLQHNQL 323
Score = 97.1 bits (240), Expect = 5e-20
Identities = 72/232 (31%), Positives = 108/232 (46%), Gaps = 27/232 (11%)
Query: 90 VHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG 149
V TV G L FP N+ + + L LQ N +Q + L++L L L+L +N IS+ G
Sbjct: 55 VDTVDCDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEG 114
Query: 150 VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERL 209
+ D AF L+ L ++ N LS P LP L+ + N++ I + F +L +
Sbjct: 115 LPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSV 174
Query: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIP- 268
+ N L+N G+ F + S+ N LS+ PP LP + L RL+LQ+N I+ +P
Sbjct: 175 YLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPS-LERLHLQNNLISKVPR 233
Query: 269 -------------------------LTAFSNLRKLERLDISNNQLRMLTQGV 295
T FS L LE LD+S+NQL + G+
Sbjct: 234 GALSRQTQLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGL 285
Score = 96.7 bits (239), Expect = 6e-20
Identities = 61/198 (30%), Positives = 102/198 (51%), Gaps = 2/198 (1%)
Query: 52 RSLTSVPLGIPEGVTVLYLHNNQINNAGFPA-ELHNVQSVHTVYLYGNQLDEFPMNLPKN 110
R + + L G+ L L +NQ+ ++G PA L ++ +HT++LYGN LD P LP+
Sbjct: 300 RQVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRR 359
Query: 111 VRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNH 170
+R L L N++ + L L EL+L N +++ V AFR +L+ L L+ N
Sbjct: 360 LRALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQ 419
Query: 171 LSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLT 230
L+ +P+GLP L+ L++ N++ ++ L L L + N L I GT+ L
Sbjct: 420 LTRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQ 479
Query: 231 KLK-EFSIVRNSLSHPPP 247
L+ +V +++ PP
Sbjct: 480 ALQVRHRLVSHTVPRAPP 497
Score = 93.6 bits (231), Expect = 5e-19
Identities = 68/224 (30%), Positives = 103/224 (45%), Gaps = 2/224 (0%)
Query: 68 LYLHNNQINNAGFPAELHN-VQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISR 126
LYL +NQ+ ++G A + + S+ + L NQL P LP+ + +LHL N I+ +
Sbjct: 245 LYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIRQVEA 304
Query: 127 AALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELR 186
A L L L L N + + G+ GA R L L L N L VP LP L+ L
Sbjct: 305 ARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALV 364
Query: 187 VDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPP 246
+ N +A + L L + N L + + F L L+ + N L+ P
Sbjct: 365 LPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLP 424
Query: 247 PDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM 290
LP T L L LQ NQ+ + + L +L L +++N+LR+
Sbjct: 425 MGLP-TGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRV 467
Score = 36.6 bits (83), Expect = 0.076
Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 20/149 (13%)
Query: 257 LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRM--LTQGVFDNLSNLKQLTARNNPWFC 314
L LQ+NQ+ +P S L L L++ NN + L F++L+ L+ L +N
Sbjct: 79 LSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQLQHLCVAHNK--- 135
Query: 315 DCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVREL----NMNLLSCPTTTPGLPLF 370
++ +++P SL V ++ + E ++ L + + GLP
Sbjct: 136 ------LSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSNAGLP-- 187
Query: 371 TPAPSTASPTTQPPTLSIPNPSRSYTPPT 399
P + TLS+ N SY PP+
Sbjct: 188 ---PDAFRGSEAIATLSLSNNQLSYLPPS 213
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 120 bits (301), Expect = 4e-27
Identities = 153/600 (25%), Positives = 244/600 (40%), Gaps = 97/600 (16%)
Query: 36 CPSVCRCDR-NFVYCNERSLTSVPLGIPEGVTVLYLHNNQIN--NAGFPAELHNVQSVHT 92
CPS C+C + V+C R T+VP +P LY+ N I +AG A L +Q +
Sbjct: 24 CPSGCQCSQPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPGLQLLD- 82
Query: 93 VYLYGNQLDEFPMNLPK---NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG 149
L NQ+ P + + N+ L L N + I+ L +LE L+L N I +
Sbjct: 83 --LSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIRHI- 139
Query: 150 VEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERL 209
+ GAF L L L N L ++P P+ L L ++ D++ +L +LE
Sbjct: 140 -QPGAFDTLDRLLELKLQDNELRALP---PLRLPRL--------LLLDLSHNSLLALEPG 187
Query: 210 IVD-GNL-------LTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTH-LIRLYLQ 260
I+D N+ L + + EG FS L L + + N L PP + G L RL L
Sbjct: 188 ILDTANVEALRLAGLGLQQLDEGLFSRLRNLHDLDVSDNQLERVPPVIRGLRGLTRLRLA 247
Query: 261 DN-QINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIK 319
N +I + + L L+ LD+SN L+ L + L+ L A NP+ C C +
Sbjct: 248 GNTRIAQLRPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLS 307
Query: 320 WVTEWLKYIPSSL-NVRGFMCQGPEQVRGMAVRELNMNLLSCP--TTTPGLPLFTP---- 372
W W++ +L + C P + G + EL+ CP TTT +P P
Sbjct: 308 WFGPWVRESHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVRE 367
Query: 373 --------APSTASPT-----------TQPPTLSIPNPSRSYTPPTPT----TSKLPT-- 407
AP+ SPT T PPT+ P P PP+ T L T
Sbjct: 368 PTALSSSLAPTWLSPTEPATEAPSPPSTAPPTVG-PVPQPQDCPPSTCLNGGTCHLGTRH 426
Query: 408 -----IPDW---------------DGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTV 447
P+ VTP + L I V+ TS++V
Sbjct: 427 HLACLCPEGFTGLYCESQMGQGTRPSPTPVTPRPPRSLTLGIEPVSPTSLRVGLQRYLQG 486
Query: 448 MAYKLTWVKMGHSLVGG----IVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRA 503
+ +L +++ + + G +V R+ + ++ ++ L P +TY +C++PL
Sbjct: 487 SSVQLRSLRLTYRNLSGPDKRLVTLRLPASLAEY-TVTQLRPNATYSVCVMPLGPGRVPE 545
Query: 504 VEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFC 563
E+ C EA T + +N + + E P L+A + ++ L + + +C
Sbjct: 546 GEEA-CGEAHTPPAVHSNHAPVTQAREGNL------PLLIAPALAAVLLAALAAVGAAYC 598
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 117 bits (292), Expect = 4e-26
Identities = 76/262 (29%), Positives = 130/262 (49%), Gaps = 29/262 (11%)
Query: 36 CPSVCRCDRNFVYCNERSLTSVPLGIP---------------------EGVTVLY---LH 71
CP C+C V+C++ LTSVP IP +G+T LY L+
Sbjct: 75 CPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILN 134
Query: 72 NNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQ 131
NN++ P + + +YL NQL E P+NLPK++ L + EN ++ I +
Sbjct: 135 NNKLTKI-HPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKG 193
Query: 132 LLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENR 191
+ L L + N + G+E GAF E +++ + +++ L+SVP GLP L EL +D N+
Sbjct: 194 MNALHVLEMSANPLDNNGIEPGAF-EGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNK 252
Query: 192 IAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPG 251
I+ + F+ L+RL + N +T+ I G+ +++ +++E + N L P LP
Sbjct: 253 ISTVELEDFKRYKELQRLGLGNNKITD--IENGSLANIPRVREIHLENNKLKKIPSGLPE 310
Query: 252 THLIR-LYLQDNQINHIPLTAF 272
++ ++L N I + + F
Sbjct: 311 LKYLQIIFLHSNSIARVGVNDF 332
Score = 109 bits (272), Expect = 9e-24
Identities = 74/233 (31%), Positives = 115/233 (49%), Gaps = 17/233 (7%)
Query: 100 LDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAI 159
L P N+P + R+L LQ N I+ I L L L L++N ++ + + AF
Sbjct: 93 LTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPK--AFLTTK 150
Query: 160 SLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNK 219
L+ L+LS N LS +P+ LP L ELR+ EN++ I F+ + +L L + N L N
Sbjct: 151 KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN 210
Query: 220 GIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLE 279
GI G F +T + I L+ P LP T L+ L+L N+I+ + L F ++L+
Sbjct: 211 GIEPGAFEGVT-VFHIRIAEAKLTSVPKGLPPT-LLELHLDYNKISTVELEDFKRYKELQ 268
Query: 280 RLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSL 332
RL + NN++ + G N+ ++++ NN LK IPS L
Sbjct: 269 RLGLGNNKITDIENGSLANIPRVREIHLENNK-------------LKKIPSGL 308
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 116 bits (291), Expect = 6e-26
Identities = 92/288 (31%), Positives = 132/288 (45%), Gaps = 30/288 (10%)
Query: 100 LDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAI 159
L E P ++P N R L+LQEN IQ I L LE L L N + + V GAF
Sbjct: 77 LAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEV--GAFNGLP 134
Query: 160 SLKLLFLSKNHLSSVPVGLPVDLQELR---VDENRIAVISDMAFQNLTSLERLIVDGNLL 216
SL L L N L++VP L +LR + N I I AF + SL RL + G L
Sbjct: 135 SLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDL-GELK 193
Query: 217 TNKGIAEGTFSHLTKLKEFSIVRNSLSHPPP-----------------DL--PG-----T 252
+ I+E F L L+ ++ +L P DL PG T
Sbjct: 194 RLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLT 253
Query: 253 HLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPW 312
L +L+L Q+ I AF +L+ LE L++S+N L L +F L L+++ +NPW
Sbjct: 254 SLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPW 313
Query: 313 FCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
C+C + W++ WLK S C P ++G + EL+ + +C
Sbjct: 314 HCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC 361
Score = 63.9 bits (154), Expect = 4e-10
Identities = 45/142 (31%), Positives = 73/142 (51%), Gaps = 5/142 (3%)
Query: 167 SKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTF 226
++ L+ VP +PV+ + L + EN I VI F++L LE L + NL+ + I G F
Sbjct: 73 TRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLV--RKIEVGAF 130
Query: 227 SHLTKLKEFSIVRNSLSHPPPDLPG--THLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
+ L L + N L+ P + L L+L++N I IP AF+ + L RLD+
Sbjct: 131 NGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLG 190
Query: 285 N-NQLRMLTQGVFDNLSNLKQL 305
+L +++ F+ L NL+ L
Sbjct: 191 ELKRLEYISEAAFEGLVNLRYL 212
>gi|109809759 leucine rich repeat transmembrane neuronal 3 [Homo
sapiens]
Length = 581
Score = 111 bits (278), Expect = 2e-24
Identities = 97/376 (25%), Positives = 159/376 (42%), Gaps = 20/376 (5%)
Query: 36 CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYL 95
CP CRC+ VYC + L +P I G L L N + + + + + +YL
Sbjct: 34 CPKGCRCEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYN-QFKGLNQLTWLYL 92
Query: 96 YGNQL---DEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVED 152
N + DE N + ++ L L N I + L L L N + ++G E
Sbjct: 93 DHNHISNIDENAFNGIRRLKELILSSNRISYFLNNTFRPVTNLRNLDLSYNQLHSLGSEQ 152
Query: 153 GAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDE---NRIAVISDMAFQNLTSLERL 209
FR L L L N L ++PV + D + L + + NRI ++ F + L+ L
Sbjct: 153 --FRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKEL 210
Query: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT--HLIRLYLQDNQINHI 267
++ N + +A F L L+ + N +S + T L RL L N+I
Sbjct: 211 HLEHNQFSKLNLA--LFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAF 268
Query: 268 P-LTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLK 326
+ F + L+RL++ +N+L + Q + D+ +L ++ N W C +I + WLK
Sbjct: 269 SGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNICSLVNWLK 328
Query: 327 YIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTL 386
L +C P++++G+ V + N C +T F A + PT +P
Sbjct: 329 SF-KGLRENTIICASPKELQGVNVIDAVKNYSICGKST--TERFDLARALPKPTFKP--- 382
Query: 387 SIPNPSRSYTPPTPTT 402
+P P PP P T
Sbjct: 383 KLPRPKHESKPPLPPT 398
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 109 bits (272), Expect = 9e-24
Identities = 103/405 (25%), Positives = 176/405 (43%), Gaps = 88/405 (21%)
Query: 26 LYSQVSKLLACPSVCRCD-------------RNFVYCNERSLTSVPLGIPEGVTVLYLHN 72
L V K + CP +C C+ + V CN+ L + P +P +L L
Sbjct: 19 LVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQT 78
Query: 73 NQI-----------NNAGFPAELHNVQSVH-----------TVYLYGNQLDEFP---MNL 107
N I N G +N+ SV +VYL N+L E P ++
Sbjct: 79 NNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSE 138
Query: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG------------------ 149
N++ L++ N + TIS A L L LHL+ N + +
Sbjct: 139 LSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
Query: 150 ----VEDGAFREAISLKLLFLSKNHLSSVP----VGLPVDLQELRVDENRIAVISDMAFQ 201
++D F+ I+L+ L ++ +L+ +P VGL +L+ + +NR+ + +A Q
Sbjct: 199 PIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE-NLESISFYDNRLIKVPHVALQ 257
Query: 202 NLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL-------SHPPPDLPGTHL 254
+ +L+ L ++ N + I G FS++ LKE I N++ S +LP
Sbjct: 258 KVVNLKFLDLNKNPINR--IRRGDFSNMLHLKELGI--NNMPELISIDSLAVDNLPDLRK 313
Query: 255 IRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFC 314
I + ++++I AF L KLE L +++N L L G ++L NLK+++ +NP C
Sbjct: 314 IEA-TNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRC 372
Query: 315 DCSIKWVTEWLKYIPSSLNVR-----GFMCQGPEQVRGMAVRELN 354
DC I+W+ + N+R C P + +G VR+++
Sbjct: 373 DCVIRWMN------MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVH 411
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 109 bits (272), Expect = 9e-24
Identities = 103/405 (25%), Positives = 176/405 (43%), Gaps = 88/405 (21%)
Query: 26 LYSQVSKLLACPSVCRCD-------------RNFVYCNERSLTSVPLGIPEGVTVLYLHN 72
L V K + CP +C C+ + V CN+ L + P +P +L L
Sbjct: 19 LVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQT 78
Query: 73 NQI-----------NNAGFPAELHNVQSVH-----------TVYLYGNQLDEFP---MNL 107
N I N G +N+ SV +VYL N+L E P ++
Sbjct: 79 NNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSE 138
Query: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG------------------ 149
N++ L++ N + TIS A L L LHL+ N + +
Sbjct: 139 LSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
Query: 150 ----VEDGAFREAISLKLLFLSKNHLSSVP----VGLPVDLQELRVDENRIAVISDMAFQ 201
++D F+ I+L+ L ++ +L+ +P VGL +L+ + +NR+ + +A Q
Sbjct: 199 PIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE-NLESISFYDNRLIKVPHVALQ 257
Query: 202 NLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL-------SHPPPDLPGTHL 254
+ +L+ L ++ N + I G FS++ LKE I N++ S +LP
Sbjct: 258 KVVNLKFLDLNKNPINR--IRRGDFSNMLHLKELGI--NNMPELISIDSLAVDNLPDLRK 313
Query: 255 IRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFC 314
I + ++++I AF L KLE L +++N L L G ++L NLK+++ +NP C
Sbjct: 314 IEA-TNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRC 372
Query: 315 DCSIKWVTEWLKYIPSSLNVR-----GFMCQGPEQVRGMAVRELN 354
DC I+W+ + N+R C P + +G VR+++
Sbjct: 373 DCVIRWMN------MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVH 411
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 109 bits (272), Expect = 9e-24
Identities = 103/405 (25%), Positives = 176/405 (43%), Gaps = 88/405 (21%)
Query: 26 LYSQVSKLLACPSVCRCD-------------RNFVYCNERSLTSVPLGIPEGVTVLYLHN 72
L V K + CP +C C+ + V CN+ L + P +P +L L
Sbjct: 19 LVQAVDKKVDCPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQT 78
Query: 73 NQI-----------NNAGFPAELHNVQSVH-----------TVYLYGNQLDEFP---MNL 107
N I N G +N+ SV +VYL N+L E P ++
Sbjct: 79 NNIAKIEYSTDFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSE 138
Query: 108 PKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVG------------------ 149
N++ L++ N + TIS A L L LHL+ N + +
Sbjct: 139 LSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGEN 198
Query: 150 ----VEDGAFREAISLKLLFLSKNHLSSVP----VGLPVDLQELRVDENRIAVISDMAFQ 201
++D F+ I+L+ L ++ +L+ +P VGL +L+ + +NR+ + +A Q
Sbjct: 199 PIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLE-NLESISFYDNRLIKVPHVALQ 257
Query: 202 NLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL-------SHPPPDLPGTHL 254
+ +L+ L ++ N + I G FS++ LKE I N++ S +LP
Sbjct: 258 KVVNLKFLDLNKNPINR--IRRGDFSNMLHLKELGI--NNMPELISIDSLAVDNLPDLRK 313
Query: 255 IRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFC 314
I + ++++I AF L KLE L +++N L L G ++L NLK+++ +NP C
Sbjct: 314 IEA-TNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRC 372
Query: 315 DCSIKWVTEWLKYIPSSLNVR-----GFMCQGPEQVRGMAVRELN 354
DC I+W+ + N+R C P + +G VR+++
Sbjct: 373 DCVIRWMN------MNKTNIRFMEPDSLFCVDPPEFQGQNVRQVH 411
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 108 bits (270), Expect = 2e-23
Identities = 83/277 (29%), Positives = 133/277 (48%), Gaps = 39/277 (14%)
Query: 110 NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKN 169
N+ +L L NN+ I++ L LL L+ELHL N+I+ + + F + +S L L+ N
Sbjct: 264 NMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE--LDLTFN 321
Query: 170 HLSSVP----VGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLT-NKGIAEG 224
HLS + +GL + L L + NR++ I+D AF+ L+SL+ L + N ++ G
Sbjct: 322 HLSRLDDSSFLGLSL-LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG 380
Query: 225 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
FS L KL+ RL LQ N+I I AF+ L LE LD+S
Sbjct: 381 AFSGLDKLR----------------------RLILQGNRIRSITKKAFTGLDALEHLDLS 418
Query: 285 NNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFM---CQG 341
+N + L F + L+QL + CDC +KW+ +W+ + N + F+ C
Sbjct: 419 DNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWV----AENNFQSFVNASCAH 474
Query: 342 PEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTAS 378
P+ ++G ++ ++ + C P T P T S
Sbjct: 475 PQLLKGRSIFAVSPDGFVCDDFPK--PQITVQPETQS 509
Score = 98.2 bits (243), Expect = 2e-20
Identities = 93/326 (28%), Positives = 152/326 (46%), Gaps = 34/326 (10%)
Query: 24 LGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAE 83
LG S V+ CP+ CRC + + C+ + L +P +P V L L +N+++ +
Sbjct: 35 LGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIK-ASS 93
Query: 84 LHNVQSVHTVYLYGNQLDEFPMNLP--KNVRVLHLQENNIQTISRAALAQLLKLEELHLD 141
+ ++QS+ V L N+L+ P P N+ +L L N I I L + LE L L
Sbjct: 94 MSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLS 153
Query: 142 DNSIS--------------------TVGVEDGAFRE-AISLKLLFLSKNHLSSVP---VG 177
N+IS +E G F A +L +L L++N +S++P
Sbjct: 154 SNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK 213
Query: 178 LPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSI 237
LP LQ L ++ N+I + + FQ L +L+ L + N +T + +G F L+ ++ +
Sbjct: 214 LP-QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTK--LMDGAFWGLSNMEILQL 270
Query: 238 VRNSLSHPPPD-LPGTHLIR-LYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGV 295
N+L+ L G +++ L+L N IN I A+ +KL LD++ N L L
Sbjct: 271 DHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSS 330
Query: 296 FDNLSNLKQLTARNN--PWFCDCSIK 319
F LS L L NN + DC+ +
Sbjct: 331 FLGLSLLNTLHIGNNRVSYIADCAFR 356
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 108 bits (270), Expect = 2e-23
Identities = 83/277 (29%), Positives = 133/277 (48%), Gaps = 39/277 (14%)
Query: 110 NVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKN 169
N+ +L L NN+ I++ L LL L+ELHL N+I+ + + F + +S L L+ N
Sbjct: 204 NMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSE--LDLTFN 261
Query: 170 HLSSVP----VGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLT-NKGIAEG 224
HLS + +GL + L L + NR++ I+D AF+ L+SL+ L + N ++ G
Sbjct: 262 HLSRLDDSSFLGLSL-LNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNG 320
Query: 225 TFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDIS 284
FS L KL+ RL LQ N+I I AF+ L LE LD+S
Sbjct: 321 AFSGLDKLR----------------------RLILQGNRIRSITKKAFTGLDALEHLDLS 358
Query: 285 NNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFM---CQG 341
+N + L F + L+QL + CDC +KW+ +W+ + N + F+ C
Sbjct: 359 DNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWV----AENNFQSFVNASCAH 414
Query: 342 PEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTAS 378
P+ ++G ++ ++ + C P T P T S
Sbjct: 415 PQLLKGRSIFAVSPDGFVCDDFPK--PQITVQPETQS 449
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/203 (26%), Positives = 93/203 (45%), Gaps = 18/203 (8%)
Query: 116 LQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVP 175
L N + I ++++ L L E+ L++N + T+ + ++ LL L+ N + +
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETI---PNLGPVSANITLLSLAGNRIVEI- 76
Query: 176 VGLPVDLQE------LRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHL 229
LP L+E L + N I+ + AF L L+ L ++ N +T+ + G F +L
Sbjct: 77 --LPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTS--MEPGYFDNL 130
Query: 230 TK-LKEFSIVRNSLSHPPPDL-PGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQ 287
L + RN +S PP + L L L N+I ++ F L L+ L + N
Sbjct: 131 ANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNG 190
Query: 288 LRMLTQGVFDNLSNLKQLTARNN 310
+ L G F LSN++ L +N
Sbjct: 191 VTKLMDGAFWGLSNMEILQLDHN 213
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 107 bits (266), Expect = 5e-23
Identities = 100/384 (26%), Positives = 154/384 (40%), Gaps = 25/384 (6%)
Query: 35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQIN--NAGFPAELHNVQSVHT 92
ACP CRCD VYC + +P I G L L N I + A L+ + ++
Sbjct: 33 ACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYL 92
Query: 93 VYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVED 152
+ Y + +DE + ++ L L N I + + L L L N + T+ E
Sbjct: 93 DHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQ 152
Query: 153 GAFREAISLKLLFLSKNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERL 209
F+ L +L L N L +VP+ + D L L + NR+ +S AF L L+ L
Sbjct: 153 --FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT--HLIRLYLQDNQINHI 267
++ N + A F L L+ + N + L T L L L N I I
Sbjct: 211 HLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGI 268
Query: 268 PLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKY 327
F L L++L++ +N+L ++Q + +L +T N W C SI + WLK
Sbjct: 269 EPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKN 328
Query: 328 IPSSLNVRGFMCQGPEQVRGMAVRE-------------LNMNLLSCPTTTPGLPLFTPAP 374
+ +C GP+ ++G V + +N TP PL P P
Sbjct: 329 FKGN-KESTMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRP 387
Query: 375 STASPTTQPPTLSIPNPSRSYTPP 398
+ P T P+PS + P
Sbjct: 388 TIFKPDVTQSTFETPSPSPGFQIP 411
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 107 bits (266), Expect = 5e-23
Identities = 100/384 (26%), Positives = 154/384 (40%), Gaps = 25/384 (6%)
Query: 35 ACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQIN--NAGFPAELHNVQSVHT 92
ACP CRCD VYC + +P I G L L N I + A L+ + ++
Sbjct: 33 ACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLKSNQFAGLNQLIWLYL 92
Query: 93 VYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVED 152
+ Y + +DE + ++ L L N I + + L L L N + T+ E
Sbjct: 93 DHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQ 152
Query: 153 GAFREAISLKLLFLSKNHLSSVPVGLPVD---LQELRVDENRIAVISDMAFQNLTSLERL 209
F+ L +L L N L +VP+ + D L L + NR+ +S AF L L+ L
Sbjct: 153 --FKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKEL 210
Query: 210 IVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGT--HLIRLYLQDNQINHI 267
++ N + A F L L+ + N + L T L L L N I I
Sbjct: 211 HLEHNQFSKINFAH--FPRLFNLRSIYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGI 268
Query: 268 PLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKY 327
F L L++L++ +N+L ++Q + +L +T N W C SI + WLK
Sbjct: 269 EPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISLISITLSGNMWECSRSICPLFYWLKN 328
Query: 328 IPSSLNVRGFMCQGPEQVRGMAVRE-------------LNMNLLSCPTTTPGLPLFTPAP 374
+ +C GP+ ++G V + +N TP PL P P
Sbjct: 329 FKGN-KESTMICAGPKHIQGEKVSDAVETYNICSEVQVVNTERSHLVPQTPQKPLIIPRP 387
Query: 375 STASPTTQPPTLSIPNPSRSYTPP 398
+ P T P+PS + P
Sbjct: 388 TIFKPDVTQSTFETPSPSPGFQIP 411
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 106 bits (265), Expect = 6e-23
Identities = 91/355 (25%), Positives = 163/355 (45%), Gaps = 27/355 (7%)
Query: 23 SLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLG----IPEGVTVLYLHNNQINNA 78
SL L S + + S R ++ + +T++ G + + V+ L+ N+++
Sbjct: 148 SLDLSSNIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSM- 206
Query: 79 GFPAELHNVQSVHTVYLYGNQL---DEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKL 135
P ++ + + + L N++ + ++R L +Q N I + A L +
Sbjct: 207 -IPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNM 265
Query: 136 EELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVG---LPVDLQELRVDENRI 192
EEL L+ N+++ V G L+ L++S+N + + L EL + N++
Sbjct: 266 EELELEHNNLTRVN--KGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQL 323
Query: 193 AVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPG- 251
+ + AF L+ LERL + N +T+ IA+G F L+ L+ + N +S D
Sbjct: 324 TRLDESAFVGLSLLERLNLGDNRVTH--IADGVFRFLSNLQTLDLRNNEISWAIEDASEA 381
Query: 252 ----THLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTA 307
T L +L LQ NQI I AF L LE LD++NN + + + F ++LK+L
Sbjct: 382 FAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQ-THLKELIL 440
Query: 308 RNNPWFCDCSIKWVTEWL--KYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSC 360
+ CDC +KW+ +WL S+NV C PE + G ++ +++ C
Sbjct: 441 NTSSLLCDCHLKWLLQWLVDNNFQHSVNV---SCAHPEWLAGQSILNVDLKDFVC 492
Score = 88.2 bits (217), Expect = 2e-17
Identities = 92/346 (26%), Positives = 143/346 (41%), Gaps = 70/346 (20%)
Query: 36 CPSVCRCDRNFVYCNERSLTSVPLG-----IPEGVTVLYLHNNQINNAGFPAELHNVQSV 90
CP+ C C + C+ R L + +P +L +N+++N E +Q V
Sbjct: 43 CPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLESQTLQEV 102
Query: 91 HTVYLYGNQLDEFPM--NLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTV 148
Y N+L E P N+ +L L N I I+ AL LE L L N IS +
Sbjct: 103 KMNY---NELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEI 159
Query: 149 G---------------------VEDGAFRE-AISLKLLFLSKNHLSSVP---VGLPVDLQ 183
+E G F + SL ++ L++N +S +P LP LQ
Sbjct: 160 KTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP-HLQ 218
Query: 184 ELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLS 243
L + NRI ++ + FQ L SL L + N ++ + +G F L ++E + N+L+
Sbjct: 219 FLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISK--LKDGAFFGLNNMEELELEHNNLT 276
Query: 244 HPPPD-LPGTHLIR-------------------------LYLQDNQINHIPLTAFSNLRK 277
L G +++ L L NQ+ + +AF L
Sbjct: 277 RVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSL 336
Query: 278 LERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTE 323
LERL++ +N++ + GVF LSNL+ L RNN I W E
Sbjct: 337 LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNN------EISWAIE 376
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 105 bits (262), Expect = 1e-22
Identities = 89/289 (30%), Positives = 137/289 (47%), Gaps = 41/289 (14%)
Query: 35 ACPSVCRC------DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQ 88
ACP+ C C D V+C+ R+LT +P G+P G L+L N +++ PA N+
Sbjct: 78 ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVP-PAAFQNLS 136
Query: 89 SVHTVYLYGNQLDEF-PMNLP--KNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSI 145
S+ + L G QL P L +N+ LHL+ N +++++ A L L L +N +
Sbjct: 137 SLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRL 196
Query: 146 STVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTS 205
S + EDG F SL +L + N +AV+ D AF+ L S
Sbjct: 197 SRL--EDGLFEGLGSL---------------------WDLNLGWNSLAVLPDAAFRGLGS 233
Query: 206 LERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL----SHPPPDLPGTHLIRLYLQD 261
L L++ GN L + FS L +L+E + RN+L ++ LP L +LYL
Sbjct: 234 LRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVFVQLP--RLQKLYLDR 289
Query: 262 NQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNN 310
N I + AF L+ L LD+S+N++ L + F L L+ L +N
Sbjct: 290 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 338
Score = 74.7 bits (182), Expect = 3e-13
Identities = 75/285 (26%), Positives = 121/285 (42%), Gaps = 49/285 (17%)
Query: 114 LHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSS 173
L L N I+ ++ + L +LE L LD N + V + GAF ++ ++ LS N L +
Sbjct: 357 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV--KAGAFLGLTNVAVMNLSGNCLRN 414
Query: 174 VPV----GLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHL 229
+P GL L L ++ + + I F L+ L RL + N L GI E + L
Sbjct: 415 LPEQVFRGLG-KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV--GIEEQSLWGL 471
Query: 230 TKLKEFSIVRNSLSHPPPDL-PGTHLIR-LYLQDNQINHIPLTAFSNLRKLERLDISNNQ 287
+L E + N L+H P L G + L L N++ +P A L++ LD+S+N+
Sbjct: 472 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 531
Query: 288 LRMLTQGVFDNLSNLKQLTARN--------------------NPWFCDCSIKWVTEWLKY 327
L L + L L+ L+ RN NPW C C +K + ++
Sbjct: 532 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQ 591
Query: 328 IPSSL------------------NVRGFMCQGPEQVRGMAVRELN 354
PS++ C P +V G+ +R+L+
Sbjct: 592 NPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLS 636
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 105 bits (262), Expect = 1e-22
Identities = 89/289 (30%), Positives = 137/289 (47%), Gaps = 41/289 (14%)
Query: 35 ACPSVCRC------DRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQ 88
ACP+ C C D V+C+ R+LT +P G+P G L+L N +++ PA N+
Sbjct: 40 ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVP-PAAFQNLS 98
Query: 89 SVHTVYLYGNQLDEF-PMNLP--KNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSI 145
S+ + L G QL P L +N+ LHL+ N +++++ A L L L +N +
Sbjct: 99 SLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRL 158
Query: 146 STVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTS 205
S + EDG F SL +L + N +AV+ D AF+ L S
Sbjct: 159 SRL--EDGLFEGLGSL---------------------WDLNLGWNSLAVLPDAAFRGLGS 195
Query: 206 LERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSL----SHPPPDLPGTHLIRLYLQD 261
L L++ GN L + FS L +L+E + RN+L ++ LP L +LYL
Sbjct: 196 LRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVFVQLP--RLQKLYLDR 251
Query: 262 NQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNN 310
N I + AF L+ L LD+S+N++ L + F L L+ L +N
Sbjct: 252 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
Score = 74.7 bits (182), Expect = 3e-13
Identities = 75/285 (26%), Positives = 121/285 (42%), Gaps = 49/285 (17%)
Query: 114 LHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSS 173
L L N I+ ++ + L +LE L LD N + V + GAF ++ ++ LS N L +
Sbjct: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV--KAGAFLGLTNVAVMNLSGNCLRN 376
Query: 174 VPV----GLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHL 229
+P GL L L ++ + + I F L+ L RL + N L GI E + L
Sbjct: 377 LPEQVFRGLG-KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV--GIEEQSLWGL 433
Query: 230 TKLKEFSIVRNSLSHPPPDL-PGTHLIR-LYLQDNQINHIPLTAFSNLRKLERLDISNNQ 287
+L E + N L+H P L G + L L N++ +P A L++ LD+S+N+
Sbjct: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNR 493
Query: 288 LRMLTQGVFDNLSNLKQLTARN--------------------NPWFCDCSIKWVTEWLKY 327
L L + L L+ L+ RN NPW C C +K + ++
Sbjct: 494 LEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQ 553
Query: 328 IPSSL------------------NVRGFMCQGPEQVRGMAVRELN 354
PS++ C P +V G+ +R+L+
Sbjct: 554 NPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLS 598
>gi|19743846 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 104 bits (260), Expect = 2e-22
Identities = 68/262 (25%), Positives = 124/262 (47%), Gaps = 28/262 (10%)
Query: 36 CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTV-- 93
CP C+C V C++ L VP +P T+L L NN+I + N++++H +
Sbjct: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIK-DGDFKNLKNLHALIL 112
Query: 94 ----------------------YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQ 131
YL NQL E P +PK ++ L EN I + +
Sbjct: 113 VNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNG 172
Query: 132 LLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENR 191
L ++ + L N + + G+E+GAF+ L + ++ +++S+P GLP L EL +D N+
Sbjct: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNK 232
Query: 192 IAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPG 251
I+ + + + L +L +L + N ++ + G+ ++ L+E + N L+ P L
Sbjct: 233 ISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGLAE 290
Query: 252 THLIR-LYLQDNQINHIPLTAF 272
I+ +YL +N I+ + + F
Sbjct: 291 HKYIQVVYLHNNNISVVGSSDF 312
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/174 (27%), Positives = 77/174 (44%), Gaps = 29/174 (16%)
Query: 155 FREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGN 214
FR L+++ S L VP LP D L + N+I I D F+NL +L LI+ N
Sbjct: 56 FRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN 115
Query: 215 LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHI------- 267
++ ++ G F+ L KL+ + +N L P +P T L L +N+I +
Sbjct: 116 KISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKT-LQELRAHENEITKVRKVTFNG 172
Query: 268 ------------PLT-------AFSNLRKLERLDISNNQLRMLTQGVFDNLSNL 302
PL AF ++KL + I++ + + QG+ +L+ L
Sbjct: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTEL 226
Score = 37.0 bits (84), Expect = 0.058
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 242 LSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSN 301
L P DLP + L LQ+N+I I F NL+ L L + NN++ ++ G F L
Sbjct: 72 LDKVPKDLPPDTTL-LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVK 130
Query: 302 LKQLTARNN 310
L++L N
Sbjct: 131 LERLYLSKN 139
>gi|4503271 decorin isoform a preproprotein [Homo sapiens]
Length = 359
Score = 104 bits (260), Expect = 2e-22
Identities = 68/262 (25%), Positives = 124/262 (47%), Gaps = 28/262 (10%)
Query: 36 CPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTV-- 93
CP C+C V C++ L VP +P T+L L NN+I + N++++H +
Sbjct: 54 CPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIK-DGDFKNLKNLHALIL 112
Query: 94 ----------------------YLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQ 131
YL NQL E P +PK ++ L EN I + +
Sbjct: 113 VNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNG 172
Query: 132 LLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENR 191
L ++ + L N + + G+E+GAF+ L + ++ +++S+P GLP L EL +D N+
Sbjct: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNK 232
Query: 192 IAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPG 251
I+ + + + L +L +L + N ++ + G+ ++ L+E + N L+ P L
Sbjct: 233 ISRVDAASLKGLNNLAKLGLSFNSIS--AVDNGSLANTPHLRELHLDNNKLTRVPGGLAE 290
Query: 252 THLIR-LYLQDNQINHIPLTAF 272
I+ +YL +N I+ + + F
Sbjct: 291 HKYIQVVYLHNNNISVVGSSDF 312
Score = 55.1 bits (131), Expect = 2e-07
Identities = 47/174 (27%), Positives = 77/174 (44%), Gaps = 29/174 (16%)
Query: 155 FREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGN 214
FR L+++ S L VP LP D L + N+I I D F+NL +L LI+ N
Sbjct: 56 FRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNN 115
Query: 215 LLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHI------- 267
++ ++ G F+ L KL+ + +N L P +P T L L +N+I +
Sbjct: 116 KISK--VSPGAFTPLVKLERLYLSKNQLKELPEKMPKT-LQELRAHENEITKVRKVTFNG 172
Query: 268 ------------PLT-------AFSNLRKLERLDISNNQLRMLTQGVFDNLSNL 302
PL AF ++KL + I++ + + QG+ +L+ L
Sbjct: 173 LNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTEL 226
Score = 37.0 bits (84), Expect = 0.058
Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 1/69 (1%)
Query: 242 LSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSN 301
L P DLP + L LQ+N+I I F NL+ L L + NN++ ++ G F L
Sbjct: 72 LDKVPKDLPPDTTL-LDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVK 130
Query: 302 LKQLTARNN 310
L++L N
Sbjct: 131 LERLYLSKN 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,712,689
Number of Sequences: 37866
Number of extensions: 1324748
Number of successful extensions: 12256
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 249
Number of HSP's successfully gapped in prelim test: 257
Number of HSP's that attempted gapping in prelim test: 7031
Number of HSP's gapped (non-prelim): 2859
length of query: 660
length of database: 18,247,518
effective HSP length: 109
effective length of query: 551
effective length of database: 14,120,124
effective search space: 7780188324
effective search space used: 7780188324
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.