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Search of human proteins with 69354671
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|69354671 ATP-binding cassette, sub-family F, member 1
isoform a [Homo sapiens]
(845 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 1683 0.0
gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform... 1349 0.0
gi|148612853 ATP-binding cassette, sub-family F (GCN20), member ... 441 e-123
gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform... 409 e-114
gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform... 409 e-114
gi|221219020 NYD-SP11 protein [Homo sapiens] 79 1e-14
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 78 4e-14
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 77 9e-14
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 73 1e-12
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 73 1e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 68 3e-11
gi|148746195 trichohyalin [Homo sapiens] 68 3e-11
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 68 3e-11
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 68 3e-11
gi|104526627 triadin [Homo sapiens] 68 4e-11
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 65 2e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 65 3e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 65 3e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 65 3e-10
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 64 4e-10
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 64 4e-10
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 64 4e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 64 4e-10
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 6e-10
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 6e-10
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 64 8e-10
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 62 2e-09
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 62 2e-09
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 62 2e-09
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 62 3e-09
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 1683 bits (4358), Expect = 0.0
Identities = 845/845 (100%), Positives = 845/845 (100%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK
Sbjct: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP
Sbjct: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE
Sbjct: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEE 240
EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEE
Sbjct: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEE 240
Query: 241 GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN 300
GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN
Sbjct: 241 GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLEN 300
Query: 301 ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI 360
ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI
Sbjct: 301 ASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNI 360
Query: 361 DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR 420
DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR
Sbjct: 361 DVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELR 420
Query: 421 ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTN 480
ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTN
Sbjct: 421 ATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTN 480
Query: 481 HLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMY 540
HLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMY
Sbjct: 481 HLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMY 540
Query: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE
Sbjct: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
Query: 601 LLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN 660
LLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN
Sbjct: 601 LLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPN 660
Query: 661 GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ 720
GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ
Sbjct: 661 GVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ 720
Query: 721 DARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA 780
DARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA
Sbjct: 721 DARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDA 780
Query: 781 LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV 840
LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV
Sbjct: 781 LGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMV 840
Query: 841 SRPRE 845
SRPRE
Sbjct: 841 SRPRE 845
>gi|10947135 ATP-binding cassette, sub-family F, member 1 isoform b
[Homo sapiens]
Length = 807
Score = 1349 bits (3492), Expect = 0.0
Identities = 712/870 (81%), Positives = 735/870 (84%), Gaps = 88/870 (10%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK
Sbjct: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
EKEQQQQQQQQQQKKKRDTRKGRRKKD
Sbjct: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKD--------------------------------- 87
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ D EE+E E+ +K + + E++ PA K + GK
Sbjct: 88 ---------------VDDDGEEKELMERL-------KKLSVPTSDEEDEVPAPKPRGGK- 124
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGK------EKAKKAEQGSEEEGEG 234
K K N FAAL ++ ++EEE +EK PPK K KA EQ +G+
Sbjct: 125 -----KTKGGNVFAALIQDQSEEEEE--EEKHPPKPAKPEKNRINKAVSEEQQPALKGKK 177
Query: 235 EEEEEEGGESKADDPYAHLSK-------------------KEKKKLKKQMEYERQVASLK 275
+EE+ G++K + +A L KEK K +QMEYERQVASLK
Sbjct: 178 GKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLK 237
Query: 276 AANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV 335
AANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV
Sbjct: 238 AANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV 297
Query: 336 GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEER 395
GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEER
Sbjct: 298 GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEER 357
Query: 396 RLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGG 455
RLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGG
Sbjct: 358 RLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGG 417
Query: 456 WRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVC 515
WRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVC
Sbjct: 418 WRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVC 477
Query: 516 TDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQT 575
TDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQT
Sbjct: 478 TDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQT 537
Query: 576 KEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQ 635
KEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQ
Sbjct: 538 KEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQ 597
Query: 636 GQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQ 695
GQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQ
Sbjct: 598 GQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQ 657
Query: 696 QYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAE 755
QYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAE
Sbjct: 658 QYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAE 717
Query: 756 LACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQ 815
LACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQ
Sbjct: 718 LACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQ 777
Query: 816 SVSQIDGDFEDYKREVLEALGEVMVSRPRE 845
SVSQIDGDFEDYKREVLEALGEVMVSRPRE
Sbjct: 778 SVSQIDGDFEDYKREVLEALGEVMVSRPRE 807
>gi|148612853 ATP-binding cassette, sub-family F (GCN20), member 3
[Homo sapiens]
Length = 709
Score = 441 bits (1134), Expect = e-123
Identities = 246/587 (41%), Positives = 353/587 (60%), Gaps = 27/587 (4%)
Query: 255 KKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENAS-----DIKLEKF 309
+K + +LK + E + +LK +N + + + S +++ LE++ D+++E F
Sbjct: 124 EKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRLESSGKNKSYDVRIENF 183
Query: 310 SISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEV 369
+S + L AD+ + GRRYGLVG NG GKTTLLK +A R+L +P +I +L EQEV
Sbjct: 184 DVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTTLLKMLATRSLRVPAHISLLHVEQEV 243
Query: 370 VADETPAVQAVLRADTKRLKLLEEERRLQGQLEQG--DDTAAERLEKVYEELRATGAAAA 427
D+TPA+Q+VL +D+ R LL ER L Q+ G + + A L ++Y +L A A
Sbjct: 244 AGDDTPALQSVLESDSVREDLLRRERELTAQIAAGRAEGSEAAELAEIYAKLEEIEADKA 303
Query: 428 EAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAV 487
A+A ILAGLGF P+MQ +PT++FSGGWRMR++LARALF P LL+LDEPTN LD+ A+
Sbjct: 304 PARASVILAGLGFTPKMQQQPTREFSGGWRMRLALARALFARPDLLLLDEPTNMLDVRAI 363
Query: 488 IWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKEL 547
+WL NYLQ W T+L+VSHD+ FL+ + TDIIHL +QRL YRG++ TF K Q++
Sbjct: 364 LWLENYLQTWPSTILVVSHDRNFLNAIATDIIHLHSQRLDGYRGDFETFIKSKQERLLNQ 423
Query: 548 LKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEES----QEAPELLK 603
++YE Q+ Q + + + R + R +Q + ++ PEL
Sbjct: 424 QREYEAQQ--------------QYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKP 469
Query: 604 RPKEYTVRFTFPDP-PPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGV 662
KE V FPD SPP+L L V F Y + +F L D++SRIC+VG NG
Sbjct: 470 VDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGA 529
Query: 663 GKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGF-NLPYQD 721
GKST+L LL G L P G + LKIG+F+Q + EQL + + E L R F P ++
Sbjct: 530 GKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVEQLDLNVSAVELLARKFPGRPEEE 589
Query: 722 ARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDAL 781
R LGR+G+ + LSGGQK+RV FA++ P+ ILDEPTN+LD+E+I+AL
Sbjct: 590 YRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQMTMPCPNFYILDEPTNHLDMETIEAL 649
Query: 782 GEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYK 828
G A+N ++G VI+VSHD R I +LWV E V++++G F+ Y+
Sbjct: 650 GRALNNFRGGVILVSHDERFIRLVCRELWVCEGGGVTRVEGGFDQYR 696
Score = 68.6 bits (166), Expect = 2e-11
Identities = 76/320 (23%), Positives = 133/320 (41%), Gaps = 59/320 (18%)
Query: 253 LSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQ---AEMSSRQAMLENASDIK---- 305
+ K+++ L +Q EYE Q + + F + +++ S+ MLE ++K
Sbjct: 413 IKSKQERLLNQQREYEAQQQYRQHIQVFIDRFRYNANRASQVQSKLKMLEKLPELKPVDK 472
Query: 306 -----------LEKFS--ISAHGKELFVNADLYIVAGR---------RYGLVGPNGKGKT 343
EKFS I + F +++ R R +VG NG GK+
Sbjct: 473 ESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIFSRLSVSADLESRICVVGENGAGKS 532
Query: 344 TLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQ 403
T+LK + + D P V+ + A + LK+ + QL+
Sbjct: 533 TMLKLL--------------------LGDLAP-VRGIRHAH-RNLKIGYFSQHHVEQLDL 570
Query: 404 GDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLA 463
+ +A E L + + E + R L G E+ RP SGG + RV+ A
Sbjct: 571 -NVSAVELLARKFP-------GRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFA 622
Query: 464 RALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDA 523
+ P +LDEPTNHLD+ + L L +R +++VSHD+ F+ VC ++ +
Sbjct: 623 QMTMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEG 682
Query: 524 QRLHYYRGNYMTFKKMYQQK 543
+ G + ++ + Q++
Sbjct: 683 GGVTRVEGGFDQYRALLQEQ 702
Score = 65.1 bits (157), Expect = 3e-10
Identities = 77/323 (23%), Positives = 118/323 (36%), Gaps = 59/323 (18%)
Query: 549 KQYEKQEKKLKELKAGGKSTKQAEK---QTKEALTRKQQKCRRKNQDEESQEAPELLKRP 605
K+ EK E +LK K K++EK +T L ++ + +ES+ E +
Sbjct: 121 KKLEKAEARLK-----AKQEKRSEKDTLKTSNPLVLEEASASQAGSRKESRL--ESSGKN 173
Query: 606 KEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKS 665
K Y VR D V+FG + L D + R +VG NG+GK+
Sbjct: 174 KSYDVRIENFD-------------VSFG---DRVLLAGADVNLAWGRRYGLVGRNGLGKT 217
Query: 666 TLLLLLTGKL--TPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQ--- 720
TLL +L + P H + + G L + + L+R L Q
Sbjct: 218 TLLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIAA 277
Query: 721 ----------------------------DARKCLGRFGLESHAHTIQICKLSGGQKARVV 752
A L G + SGG + R+
Sbjct: 278 GRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRMRLA 337
Query: 753 FAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVV 812
A PD+L+LDEPTN LD+ +I L + + ++VVSHD + + +
Sbjct: 338 LARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIATDIIHL 397
Query: 813 EEQSVSQIDGDFEDYKREVLEAL 835
Q + GDFE + + E L
Sbjct: 398 HSQRLDGYRGDFETFIKSKQERL 420
>gi|27881506 ATP-binding cassette, sub-family F, member 2 isoform a
[Homo sapiens]
Length = 623
Score = 409 bits (1052), Expect = e-114
Identities = 236/636 (37%), Positives = 362/636 (56%), Gaps = 41/636 (6%)
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVA 272
P K+KA K ++ ++ + EE G+ + A +K R+
Sbjct: 2 PSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVA----------EKNEANGRETT 51
Query: 273 SLKAANAAENDFSVSQAEMSSRQAMLE---NASDIKLEKFSISAHGKELFVNADLYIVAG 329
+ DF + +A + +L N++D+ + S++ HG+EL + L + +G
Sbjct: 52 EVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSG 111
Query: 330 RRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLK 389
RRYGL+G NG GK+ LL I R + IP +ID+ +E+ + + V+ DT+R
Sbjct: 112 RRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAM 171
Query: 390 LLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPT 449
L +E RL + D E+L ++YE L A AE +A RIL GLGF P MQ +
Sbjct: 172 LEKEAERLAHE-----DAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKL 226
Query: 450 QKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQG 509
+ FSGGWRMRV+LARALF+ P +L+LDEPTNHLDL+A +WL L+ +++ L++VSH Q
Sbjct: 227 KDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQD 286
Query: 510 FLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELK------A 563
FL+ VCT+IIH+ ++L YY GNY + K + ++ +K++ ++ ++ +K
Sbjct: 287 FLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFG 346
Query: 564 GGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKR-PKEYTVRFTFPDPPPLSP 622
G + + Q+KE +K A L +R + T+ F FP + P
Sbjct: 347 HGSAKLARQAQSKEKTLQKMM-------------ASGLTERVVSDKTLSFYFPPCGKIPP 393
Query: 623 PVLGLHGVTFGYQGQKP-LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGE 681
PV+ + V+F Y P ++ NL+FGID+D+R+ +VGPNG GKSTLL LLTG+L PT G
Sbjct: 394 PVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGM 453
Query: 682 MRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFN--LPYQDARKCLGRFGLESHAHTIQ 739
+RK+ +KIG ++Q EQL ++ +P EY+ + + ++ RK +GR+GL
Sbjct: 454 IRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSP 513
Query: 740 ICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDA 799
I LS GQK RV A LA + P +L LDEPTN+LDIE+IDAL +AINE++G +++VSHD
Sbjct: 514 IRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDF 573
Query: 800 RLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEAL 835
RLI + ++WV E+Q++++ GD YK + L
Sbjct: 574 RLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKL 609
>gi|10947137 ATP-binding cassette, sub-family F, member 2 isoform b
[Homo sapiens]
Length = 634
Score = 409 bits (1052), Expect = e-114
Identities = 236/636 (37%), Positives = 362/636 (56%), Gaps = 41/636 (6%)
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVA 272
P K+KA K ++ ++ + EE G+ + A +K R+
Sbjct: 2 PSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVA----------EKNEANGRETT 51
Query: 273 SLKAANAAENDFSVSQAEMSSRQAMLE---NASDIKLEKFSISAHGKELFVNADLYIVAG 329
+ DF + +A + +L N++D+ + S++ HG+EL + L + +G
Sbjct: 52 EVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLSDTKLELNSG 111
Query: 330 RRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLK 389
RRYGL+G NG GK+ LL I R + IP +ID+ +E+ + + V+ DT+R
Sbjct: 112 RRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLHCVMEVDTERAM 171
Query: 390 LLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPT 449
L +E RL + D E+L ++YE L A AE +A RIL GLGF P MQ +
Sbjct: 172 LEKEAERLAHE-----DAECEKLMELYERLEELDADKAEMRASRILHGLGFTPAMQRKKL 226
Query: 450 QKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQG 509
+ FSGGWRMRV+LARALF+ P +L+LDEPTNHLDL+A +WL L+ +++ L++VSH Q
Sbjct: 227 KDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKRILVLVSHSQD 286
Query: 510 FLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELK------A 563
FL+ VCT+IIH+ ++L YY GNY + K + ++ +K++ ++ ++ +K
Sbjct: 287 FLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQIAHMKNYIARFG 346
Query: 564 GGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKR-PKEYTVRFTFPDPPPLSP 622
G + + Q+KE +K A L +R + T+ F FP + P
Sbjct: 347 HGSAKLARQAQSKEKTLQKMM-------------ASGLTERVVSDKTLSFYFPPCGKIPP 393
Query: 623 PVLGLHGVTFGYQGQKP-LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGE 681
PV+ + V+F Y P ++ NL+FGID+D+R+ +VGPNG GKSTLL LLTG+L PT G
Sbjct: 394 PVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPTDGM 453
Query: 682 MRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFN--LPYQDARKCLGRFGLESHAHTIQ 739
+RK+ +KIG ++Q EQL ++ +P EY+ + + ++ RK +GR+GL
Sbjct: 454 IRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGKQQVSP 513
Query: 740 ICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDA 799
I LS GQK RV A LA + P +L LDEPTN+LDIE+IDAL +AINE++G +++VSHD
Sbjct: 514 IRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGMMLVSHDF 573
Query: 800 RLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEAL 835
RLI + ++WV E+Q++++ GD YK + L
Sbjct: 574 RLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKL 609
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 79.3 bits (194), Expect = 1e-14
Identities = 92/406 (22%), Positives = 178/406 (43%), Gaps = 41/406 (10%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK 85
K+ K +K K +++ +E A +K +K+ +++ + Q++ + K KR R+
Sbjct: 2051 KLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERR 2110
Query: 86 KDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEE 145
++ + + + +K S T DE K K+ K N +I + + EE
Sbjct: 2111 LSIEQSKLDIKEWDFSEKRSELTKDE-------KKLARKQRKLANKMRRMINKEEKMTEE 2163
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQ--PALKGKKGKEEKSKGKAKPQNKFAALDNEEEDK 203
E K K ++ + + EE++ P LK + K +++K KP+ KF++ +E E +
Sbjct: 2164 ESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESE 2223
Query: 204 E---EEI------IKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLS 254
E EE+ ++++E +E+ ++ E+ EEE EEEEE E + ++
Sbjct: 2224 EHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKE 2283
Query: 255 KKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAH 314
++EKKK KK+ + E + E S + E S + E + ++ E +
Sbjct: 2284 EEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEE---VDRE 2340
Query: 315 GKELFVNADLYIVAGRRYGLVG-----------PNGKGKT-------TLLKHIANRALSI 356
+ L + RR L G P+GKG+ + LK + + AL +
Sbjct: 2341 KEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKLMSTALEM 2400
Query: 357 PPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLE 402
V + E+++ ++ A V+ K L +++ER + G+ E
Sbjct: 2401 KEKTPVPVPEKQISWEDKKA--TVVEIPRKFLGTMDKEREVMGKYE 2444
Score = 60.8 bits (146), Expect = 5e-09
Identities = 59/263 (22%), Positives = 117/263 (44%), Gaps = 49/263 (18%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAG-EEEKVLKEKEQQQQQQQQQQKKKRDTRKGR 83
+K K +++ K+ + E + ++++ G EEE+V+ +++ +++++ K+ D K +
Sbjct: 2155 NKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEA--KRGDKPKEK 2212
Query: 84 RKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE 143
VD+ E+ E ++ L +E + +++ E E
Sbjct: 2213 FSSQVDEVESEEHFSEEMESLLDELEKQE--------------------SLSSEEEEERE 2252
Query: 144 EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDK 203
EEEE+ + + E+ R + EE+Q +K +EEK K K ++K
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQV----EKEEEEKKKKK--------------KEK 2294
Query: 204 EEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKK 263
++E ++EKE + KE+ E+ E EEEE E + D +EK+ LKK
Sbjct: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVD--------REKEILKK 2346
Query: 264 QMEYERQVASLKAANAAENDFSV 286
+ +++ Q K+ E S+
Sbjct: 2347 EKQFKLQEQRRKSLRGRERVLSI 2369
Score = 55.5 bits (132), Expect = 2e-07
Identities = 59/278 (21%), Positives = 124/278 (44%), Gaps = 27/278 (9%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE---------KEQQQQQQQQQQKKKRDT 79
K+ ++++K+ + E+LA E++Q +EE+ L + +E Q + + QK++
Sbjct: 1587 KRAQEERKLAQEE-EKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLA 1645
Query: 80 RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ-- 137
++G + E ++L ++ KKL+ E +GGK + N+ A ++
Sbjct: 1646 QRGEKLSQ-----EAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEEL 1700
Query: 138 -------DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ 190
D E+E +E + E + + +++E+ ++ KK E+ + A +
Sbjct: 1701 PQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQR 1760
Query: 191 NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPY 250
K + + + +EE +I+EKE Q KEK + E E G E+ E A
Sbjct: 1761 EKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEE---ERLGRKREQLIEKKMKLAQKRE 1817
Query: 251 AHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQ 288
++ E+ K + Y+++ + + N A+ ++Q
Sbjct: 1818 RWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEKLAQ 1855
Score = 54.7 bits (130), Expect = 4e-07
Identities = 100/480 (20%), Positives = 198/480 (41%), Gaps = 87/480 (18%)
Query: 18 GESTSPSDKVVKKGKK----------DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQ 67
GE SP ++++++ KK + + E+ ++++ EE+V +E E+++Q
Sbjct: 1500 GEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQ 1559
Query: 68 QQQQQQKKKRDTRKGRR---------KKDVDDD-----------GEEKELMERLKKLS-- 105
Q ++Q+ ++ K R KK ++ EE++L + +KL+
Sbjct: 1560 QVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQA 1619
Query: 106 -VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKA 164
V + ++ E+ + + +K + L Q + +E EK K K K + K
Sbjct: 1620 YVKITQDDREMAQAEGKFAQKEE------TLAQRGEKLSQEAEKLAQKRKKLAK-KWEKV 1672
Query: 165 VSEEQQPALKGKKGKEEKS----KGKAKPQNK----------FAALDNEEEDKEEEIIKE 210
EE++ A KG K E K+ K + PQ + L+ E D EE KE
Sbjct: 1673 AREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKE 1732
Query: 211 KE-PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKL---KKQME 266
+E ++GK +K + EEE + E+ E L +EK+KL K++M
Sbjct: 1733 EELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMP 1792
Query: 267 YERQVASLKAANAAENDFSVSQ---------AEMSSRQAMLENASDIKLEKFSISAHGKE 317
E + K E ++Q E++ + +L ++ EK +++ ++
Sbjct: 1793 EEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKNKMILYQKKNLAQEKKNLAQEKEK 1852
Query: 318 LFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAV 377
L + + R + K + +K+ I ++ L +++
Sbjct: 1853 LAQRKENLLYNKERL----THSKKQLVQVKNKLGMFNKILAQVEEKLTQEK--------- 1899
Query: 378 QAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAG 437
+ V++ K+ KL E E++ L Q +D+ A++ EK+ +E A + ++ L G
Sbjct: 1900 ETVIK---KKEKLAETEKK----LVQVEDSLAKKQEKLAQEKMKLALEKAMVQGKKRLRG 1952
Score = 50.1 bits (118), Expect = 9e-06
Identities = 120/650 (18%), Positives = 257/650 (39%), Gaps = 103/650 (15%)
Query: 7 QQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAV----------EDKQAGEEE 56
Q+ E EW + S + ++GK ++ KK EE A+ E K A EEE
Sbjct: 1716 QELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEEEALAWQREKLSEEETKLAQEEE 1775
Query: 57 KVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTS---DEED 113
+++EKE+ Q +++ +++ R GR+++ +L+E+ KL+ + +
Sbjct: 1776 LLIQEKEKLAQHKEKMPEEEE--RLGRKRE---------QLIEKKMKLAQKRERWINSME 1824
Query: 114 EVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPAL 173
E+ K +K L Q++ +E+EK +++ ++ L
Sbjct: 1825 ELTKNKMILYQKKN-------LAQEKKNLAQEKEK----------------LAQRKENLL 1861
Query: 174 KGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG-SEEEG 232
K+ K + +NK + EE++ +EKE + KEK + E+ + E
Sbjct: 1862 YNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLVQVED 1921
Query: 233 EGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEY--ERQVASLKAANAAENDF------ 284
+++E+ + K + KK+L+ +++ E + +L+ AE
Sbjct: 1922 SLAKKQEKLAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGK 1981
Query: 285 ---------------SVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAG 329
++Q E + L I L + I A + L G
Sbjct: 1982 ETLSKGETPETSRQRKMTQVEQELFERKLSLEEKILLHEDRILAMEESEIAKGKLEFTRG 2041
Query: 330 RRYGLVGPN--GKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKR 387
+R + G K L+K + + +L Q++ DE Q ++ +
Sbjct: 2042 QRIFVQGQRKLAKASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMK 2101
Query: 388 LKLLEEERRLQGQLEQGD----DTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPE 443
L +ERRL + + D D + +R E +E + A+ +R LA
Sbjct: 2102 RALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKL-------ARKQRKLA------- 2147
Query: 444 MQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLI 503
N+ + + +M ++ +++ DE ++ VI + WRK
Sbjct: 2148 --NKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPF--LKRRWRKRKEA 2203
Query: 504 VSHDQ------GFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKK 557
D+ +D+V ++ ++ + + + ++++E ++ E++E++
Sbjct: 2204 KRGDKPKEKFSSQVDEVESE--EHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEE 2261
Query: 558 LKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKE 607
++E + K ++ E++ E +++K +++ + EE QE E+ + +E
Sbjct: 2262 VREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEE 2311
Score = 43.1 bits (100), Expect = 0.001
Identities = 50/240 (20%), Positives = 107/240 (44%), Gaps = 27/240 (11%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
E S D++ K+ + ++ EE E+++ EEE+ KE+E+ +++Q +++++++
Sbjct: 2229 EMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKK 2288
Query: 79 TRKGRRKKDVDDDGEE-----KELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFA 133
+K +KK+ + EE +E+M + S+ +EE+E +
Sbjct: 2289 KKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEE------------------S 2330
Query: 134 ALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKG---KKGKEEKSKGKAKPQ 190
++++ + E+E K + E+ R + E L+G KG+ + P
Sbjct: 2331 CSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPL 2390
Query: 191 NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPY 250
K + E ++K + EK+ + K KA E + G ++E E G+ + P+
Sbjct: 2391 KKLMSTALEMKEKTPVPVPEKQISWEDK-KATVVEIPRKFLGTMDKEREVMGKYEPIPPH 2449
Score = 39.3 bits (90), Expect = 0.015
Identities = 45/189 (23%), Positives = 85/189 (44%), Gaps = 13/189 (6%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQ---AGEEEKVLKEK 62
+++ + E G+ + ++ KK KK+KK ++ +E E+K+ + EE + L ++
Sbjct: 2265 EEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDE 2324
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVD-DDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
E++++ +++ R+ +++K + K L R + LS+ VP K
Sbjct: 2325 EEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRG-----VPHGK-- 2377
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHP-PKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
G+ + G + + L + S E +EK P P P K KA E G KE
Sbjct: 2378 -GRAIRLGVLKSPLKKLMSTALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKE 2436
Query: 181 EKSKGKAKP 189
+ GK +P
Sbjct: 2437 REVMGKYEP 2445
Score = 35.0 bits (79), Expect = 0.29
Identities = 65/285 (22%), Positives = 117/285 (41%), Gaps = 48/285 (16%)
Query: 33 KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR-----RKKD 87
+DK+ KK ++L + K+ G+E KV+ E+ +Q KK + +G R+
Sbjct: 1176 RDKRDKKATAQKLKKKHKKKGKEAKVINEETTPPVMEQPVTKKVKIQGRGASGISGRRST 1235
Query: 88 VDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK-GGNVFAALIQDQSEEEEEE 146
D ++ + RL L + G +TK N+ A L+ +E
Sbjct: 1236 AGDGSSWRDDLCRLMALRI---------------SGSQTKMSENLNAELV--TFAQEMLV 1278
Query: 147 EKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEE 206
++HP E I + +E + L+ + K + A ++ + +E
Sbjct: 1279 DRHPSWELFQE---ICPLLKKESKVLLEDLDWDVVPPEKKPIFIQEGAIREDMIQGVTQE 1335
Query: 207 IIKEKE-PPKQGKEKAKKAEQ--GSEE------EGEGEEEEEEGGESKADDPYAHLSKKE 257
+I+ KE P++ ++ KKA G EE +G+ E G + + +SKKE
Sbjct: 1336 VIRHKEVMPREEEQAQKKARDMLGLEETQVILKKGKKVIFLEPGNVTMGKE----ISKKE 1391
Query: 258 KKKL--------KKQMEYERQVASLK-AANAAENDFSVSQAEMSS 293
+KK +K ++ ER+V +K E D S EM++
Sbjct: 1392 EKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMAT 1436
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 77.8 bits (190), Expect = 4e-14
Identities = 91/351 (25%), Positives = 148/351 (42%), Gaps = 74/351 (21%)
Query: 30 KGKKDKKIKKTFF---------EELAVEDK--QAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
KGKK K+ KK F EEL++E + +A E +K E +++ + KKK+
Sbjct: 41 KGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKG 100
Query: 79 TRKGRRKKDVDDDGEEKELME-RLKKLSVP-------TSDEEDEVPAPKPRGGKKTKGGN 130
+KG+++ D+D EE E + + KK + P + D++D PK GK K
Sbjct: 101 -QKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNK 159
Query: 131 VFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKA--VSEEQQPALKGKKGKEEKSKGKAK 188
+ D SEE+E+ K E++RIN + +E L+ +KG+++ K K
Sbjct: 160 KW-----DGSEEDEDNSK-----KIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPG 209
Query: 189 PQNKFAALDNEEEDKEEEII------KEKEPPKQGKEKAK-------------KAEQGSE 229
P + D++ K + + KE+E K+ +EKAK K +Q +
Sbjct: 210 PNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQ 269
Query: 230 EEGEGEEEEE-------------EGGESKADDPYA----------HLSKKEKKKLKKQME 266
+E + + EEE E KA+ P A KK+KK K++ E
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKE 329
Query: 267 YERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKE 317
E++ KA A + E RQ E +LE+ +E
Sbjct: 330 KEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEE 380
Score = 71.2 bits (173), Expect = 4e-12
Identities = 80/346 (23%), Positives = 148/346 (42%), Gaps = 57/346 (16%)
Query: 10 PEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKV---------LK 60
P E + + + D K KKDKK KK EE E K+ + V LK
Sbjct: 293 PASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLK 352
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGE--------EKELMERLKKLSVPTSDEE 112
E+E++Q+++++++ K+ + + +RK++ + E EKE ERLKK + +
Sbjct: 353 EEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQ 412
Query: 113 DEVPAPKPRGGK--KTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVS---- 166
E A K + +G V + + E++K P + E +++++
Sbjct: 413 REARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAA 472
Query: 167 -----------EEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPK 215
EE P ++ ++ ++ + G + + A+ ++EE ++ E K K
Sbjct: 473 VEVMEQGVPEKEETPPPVEPEEEEDTEDAGL----DDWEAMASDEETEKVEGNKVHIEVK 528
Query: 216 QGKEKAKKAEQGSEEEGEGEEEEEEGGESKAD-------------DPYAHLSKKEKKKLK 262
+ E+ ++ E+ EE+ E EEEEEE GES+ D L KK K++
Sbjct: 529 ENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMS 588
Query: 263 KQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 308
EY+ K A + +A+ + LE++ ++ EK
Sbjct: 589 SDSEYDSDDDRTKEERAYD------KAKRRIEKRRLEHSKNVNTEK 628
Score = 63.9 bits (154), Expect = 6e-10
Identities = 98/444 (22%), Positives = 175/444 (39%), Gaps = 69/444 (15%)
Query: 31 GKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDD 90
GKK K + ++ D A E E KEQ+ Q+ + ++KK++ +K+D D+
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEK------KKQDFDE 55
Query: 91 DGEEKELME-----------RLKKLSVPTSDEEDEVPA-PKPRGGKKTKGGNVFAALIQD 138
D KEL E R PT + E+E + K + G+K K + +
Sbjct: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKK----QSFDDN 111
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
SEE E+++ K AKP+ + + ++ L +K+KGKA+ NK
Sbjct: 112 DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKL------PKKAKGKAQKSNKKWDGSE 165
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGG---ESKADDPYAHL-- 253
E+ED ++I + G+ + E +G+ + ++ + G ES +D A
Sbjct: 166 EDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKI 225
Query: 254 ----SKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKF 309
KK +KK +++ + + + A L+ E + E + + S K E+
Sbjct: 226 KTVAQKKAEKKERERKKRDEEKAKLRKLKEKE------ELETGKKDQSKQKESQRKFEEE 279
Query: 310 SISAHGKELFVNADLYIVAGRRYGLVGPNG-------------KGKTTLLKHIANRALSI 356
++ + V D ++ P K K K +
Sbjct: 280 TVKSK-----VTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKK 334
Query: 357 PPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLL--------EEERRLQGQLEQGDDTA 408
P+ + QE +A + R + +R+K L EEER Q + E+
Sbjct: 335 GPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKE 394
Query: 409 AERLEKVYEELRATGAAAAEAKAR 432
ER E++ +E + + EA+AR
Sbjct: 395 KERKERLKKEGKLLTKSQREARAR 418
Score = 30.8 bits (68), Expect = 5.5
Identities = 21/67 (31%), Positives = 41/67 (61%), Gaps = 3/67 (4%)
Query: 542 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTR-KQQKCRRKNQDEESQEAPE 600
+K+K+ K+ ++E+K KE K G +K K +EAL + K+++ R+K ++EE + E
Sbjct: 313 KKKKDKKKKKGEKEEKEKEKKKG--PSKATVKAMQEALAKLKEEEERQKREEEERIKRLE 370
Query: 601 LLKRPKE 607
L+ ++
Sbjct: 371 ELEAKRK 377
Score = 30.0 bits (66), Expect = 9.4
Identities = 38/197 (19%), Positives = 83/197 (42%), Gaps = 19/197 (9%)
Query: 23 PSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKG 82
P + + + KK KKI + +E K+ E ++ E +Q ++++
Sbjct: 440 PKKRPIYEDKKRKKIPQQ------LESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP- 492
Query: 83 RRKKDVDDDG----------EEKELMERLK-KLSVPTSDEEDEVPAPKPRGGKKTKGGNV 131
++D +D G EE E +E K + V + EE+E + ++++
Sbjct: 493 EEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEE 552
Query: 132 FAALIQDQSEEEEEEEKHPPKPA-KPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ 190
+ +EE+E+ K + K + +K +S + + + KEE++ KAK +
Sbjct: 553 EEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRR 612
Query: 191 NKFAALDNEEEDKEEEI 207
+ L++ + E++
Sbjct: 613 IEKRRLEHSKNVNTEKL 629
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 76.6 bits (187), Expect = 9e-14
Identities = 71/322 (22%), Positives = 148/322 (45%), Gaps = 18/322 (5%)
Query: 6 KQQPPEPEWIG-DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64
K+ + EW DGE ++ ++G + ++ ++ EE E+ GEEE+ +E+E+
Sbjct: 694 KELAEKEEWKKRDGEEQEQKER--EQGHQKERNQE--MEEGGEEEHGEGEEEEGDREEEE 749
Query: 65 QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGK 124
+++ + +++ + + R K++ + EE+ E + + E+E + RG +
Sbjct: 750 EKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE--ETEGRGEE 807
Query: 125 KTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK------G 178
K +GG V +++ E EEEE+ + + + EE++ KG++ G
Sbjct: 808 KEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEG 867
Query: 179 KEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEE 238
+EE +G+ + + + + EEE + E +E+E +G+E+ + + E EG+GEEE
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEG--EEEEGEGEGEEEGEGEGEEEEGEGKGEEEG 925
Query: 239 EEG---GESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQ 295
EEG GE + + + E ++ + + E E + + E + + E +
Sbjct: 926 EEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEE 985
Query: 296 AMLENASDIKLEKFSISAHGKE 317
E + E+ G+E
Sbjct: 986 GEGEGEEEEGEEEGEEEGEGEE 1007
Score = 72.0 bits (175), Expect = 2e-12
Identities = 79/296 (26%), Positives = 140/296 (47%), Gaps = 59/296 (19%)
Query: 12 PEWIGDGESTSPS-------DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64
PE GDG S D+ +KG+KDK E ++ GE EK L EKE+
Sbjct: 651 PEGRGDGTCEEGSSGAEHWQDEEREKGEKDKG---------RGEMERPGEGEKELAEKEE 701
Query: 65 QQQQ--QQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
+++ ++Q+QK++ + R +++++ GEE E E ++ +EE E +
Sbjct: 702 WKKRDGEEQEQKEREQGHQKERNQEMEEGGEE-EHGEGEEEEGDREEEEEKEGEGKEEGE 760
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRI--NKAVSEEQQPALKGKK--- 177
G++ +G + E+EE E K + K EK ++ EE++ +G++
Sbjct: 761 GEEVEG----------EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEE 810
Query: 178 ------GKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK--EKEPPKQGKEKAKKAE---- 225
G+ E+ KG+ + + + + EE + EEE + E+E +G+E+ ++ E
Sbjct: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEE 870
Query: 226 ------QGSEEEGEG--EEE-----EEEGGESKADDPYAHLSKKEKKKLKKQMEYE 268
+G EEEGEG EEE EEE GE + ++ ++E+ + K + E E
Sbjct: 871 GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGE 926
Score = 65.1 bits (157), Expect = 3e-10
Identities = 65/257 (25%), Positives = 115/257 (44%), Gaps = 36/257 (14%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
EE+ + +++ G E+ E+Q+ + ++ K RK + + DD ++ E+ E
Sbjct: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKA 641
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
K + ED P+ RG + G+ A QD+ E+ E++K + +P +
Sbjct: 642 K---SVGEAED---GPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKE 695
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE---------DKEEEIIKEKEP 213
A EE + ++ ++E+ +G K +N+ EEE D+EEE KE E
Sbjct: 696 LAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEG 755
Query: 214 PKQGK------------------EKAKKAEQGSEE--EGEGEEEEEEGGESKADDPYAHL 253
++G+ E+A K E+G EE +GEGEEEE E G + + +
Sbjct: 756 KEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE-GRGEEKEEGGEV 814
Query: 254 SKKEKKKLKKQMEYERQ 270
E ++ K + E E +
Sbjct: 815 EGGEVEEGKGEREEEEE 831
Score = 62.8 bits (151), Expect = 1e-09
Identities = 68/310 (21%), Positives = 138/310 (44%), Gaps = 11/310 (3%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ 70
E E G GE + ++G++ + + E E++ GE E+ E E +++ +
Sbjct: 851 EEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEG 910
Query: 71 QQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG-GKKTKGG 129
+ ++++ + + ++ + +GEE+E + +EE E + G G+ + G
Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEG 970
Query: 130 NVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKP 189
+ + EEEE E + + + E + E + G+ +EE+ + + +
Sbjct: 971 EGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGE-----GEGEEEEEGEVEGEV 1025
Query: 190 QNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDP 249
+ + + EEE+ EEE +E+E +G+E + E+ EEEG+ +E EE E + +
Sbjct: 1026 EGEEGEGEGEEEEGEEEG-EEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
Query: 250 YAHLSK-KEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 308
Y +SK K K K Y+++ + N E S+ + S++ + S K
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQR---SKMPVQSKRLLKNGPSGSKKFW 1141
Query: 309 FSISAHGKEL 318
++ H EL
Sbjct: 1142 NNVLPHYLEL 1151
Score = 62.4 bits (150), Expect = 2e-09
Identities = 74/303 (24%), Positives = 142/303 (46%), Gaps = 38/303 (12%)
Query: 11 EPEWIGDGESTSPSDKV----VKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQ 66
E E G GE +V V++GK +++ ++ E E++ GEEE+ E+E+ +
Sbjct: 798 EEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE--EGEGEEEEGEGEEEEGEGEEEEGE 855
Query: 67 QQQQQQQKKKRDTRKGRR------KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
+ +++ ++ +G +++ + +GEE+ E ++ +EE E +
Sbjct: 856 GKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEE 915
Query: 121 RG-GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGK 179
G GK + G + + E EEEE + + + E EE++ +G+
Sbjct: 916 EGEGKGEEEGE------EGEGEGEEEEGEGEGEDGEGE--------GEEEEGEWEGE--- 958
Query: 180 EEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEE-EGEGEEEE 238
EE+ +G+ + + + + E E +EEE E E ++G+E+ ++ +G EE EGEGEEEE
Sbjct: 959 EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE-EEGEEEGEEEGEGEEEGEGEGEEEE 1017
Query: 239 E---EG---GESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
E EG GE + ++E ++ +K+ E E + + E + + E +
Sbjct: 1018 EGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEEN 1077
Query: 293 SRQ 295
RQ
Sbjct: 1078 ERQ 1080
Score = 54.3 bits (129), Expect = 5e-07
Identities = 84/336 (25%), Positives = 133/336 (39%), Gaps = 96/336 (28%)
Query: 8 QPPEPEWIGDGESTSP----SDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKE 63
QP EP+++ D + S V G+ + T L EK LK
Sbjct: 467 QPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSL-------NSNEKSLKLSP 519
Query: 64 QQQQQQQQQ-QKKKRDTRKGRRKKDVDDDGEEKELMERLKK-------------LSVPT- 108
Q+Q++QQ + +DT +DD +E E M +K+ ++ P
Sbjct: 520 VQKQKKQQTIGELTQDTALTE-----NDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPAT 574
Query: 109 -----SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRI-- 161
SDEE E+P K G + +KG + ++ E E EE + EK I
Sbjct: 575 TIEAFSDEEVEIPEEK-EGAEDSKGNGI------EEQEVEANEENVKVHGGRKEKTEILS 627
Query: 162 -------------NKAVSE-EQQPALKG-------------------KKGKEEKSKGK-A 187
K+V E E P +G +KG+++K +G+
Sbjct: 628 DDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEME 687
Query: 188 KPQNKFAALDNEEE----DKEEEIIKEKEPPKQGKEKAKKAE----------QGSEEEGE 233
+P L +EE D EE+ KE+E QG +K + E +G EEEG+
Sbjct: 688 RPGEGEKELAEKEEWKKRDGEEQEQKERE---QGHQKERNQEMEEGGEEEHGEGEEEEGD 744
Query: 234 GEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYER 269
EEEEE+ GE K + + + +K+ ++ + ER
Sbjct: 745 REEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEER 780
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 73.2 bits (178), Expect = 1e-12
Identities = 62/254 (24%), Positives = 119/254 (46%), Gaps = 40/254 (15%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ 70
+P W + + K+GKK+++ ++ +E +K+ E EK K + +++++
Sbjct: 31 QPGWQSEIREREREIETRKEGKKERESERK--KERREREKRKREREKERKRERGKKEKKG 88
Query: 71 QQQKKKRDTRKGRRKKDVDDDGEEKELMERL-KKLSVPTSDEEDEVPAPKPRGGKKTKGG 129
+++K++R+ +K RR+K+ + +GEEKE ++ KK TS E E + R ++ K
Sbjct: 89 ERKKEERERKKRRREKE-NKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK-- 145
Query: 130 NVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKP 189
E ++EE+ + K K R K V E KEE+ K K +
Sbjct: 146 ----------ERERKKEEREKERERKERKKRERKQVGE-----------KEEERKEKERK 184
Query: 190 QNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDP 249
+ K + +E KE E + +E K+ K+K ++ ++ ++ E+E G
Sbjct: 185 ERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERG-------- 236
Query: 250 YAHLSKKEKKKLKK 263
K+E+K+ KK
Sbjct: 237 -----KRERKERKK 245
Score = 61.6 bits (148), Expect = 3e-09
Identities = 48/205 (23%), Positives = 98/205 (47%), Gaps = 23/205 (11%)
Query: 67 QQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT 126
Q + ++++++ +TRK +K+ + +E+ E+ K+ E E + RG K+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKR--------EREKERKRERGKKEK 86
Query: 127 KGGNVFAALIQDQSEEEEEEEK-HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKG 185
KG ++ +EE E +K K K + + + E+++ K+GKE + K
Sbjct: 87 KG---------ERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE 137
Query: 186 KAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+ K + + E E K+EE KE+E ++ K + K+ + EE E E +E + E
Sbjct: 138 ERKREER-----KERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERN 192
Query: 246 ADDPYAHLSKKEKKKLKKQMEYERQ 270
+ +KE+++ KK+ + + +
Sbjct: 193 RKERKKERERKERRERKKERKKKEE 217
Score = 55.5 bits (132), Expect = 2e-07
Identities = 39/173 (22%), Positives = 81/173 (46%), Gaps = 1/173 (0%)
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAAL 196
+ + E E E +K + K ++ R + E + KG++ KEE+ + K + + +
Sbjct: 50 EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEG 109
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKK 256
+ +E+ K++E + K+GKE+ +K E+ EE E E ++EE + + +K
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERK 169
Query: 257 EK-KKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 308
+ +K +++ E ER+ + N E + E R+ + + K E+
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKER 222
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/172 (22%), Positives = 81/172 (47%), Gaps = 8/172 (4%)
Query: 139 QSE-EEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
QSE E E E K K E+ K E++ + ++ + ++ +GK + + +
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKG-----E 89
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKE 257
++E++E + + ++ K+G+EK K+ ++ +E G +E +E E K + ++E
Sbjct: 90 RKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKE-RERKEERKREERKERE 148
Query: 258 KKKLKKQMEYERQVASLK-AANAAENDFSVSQAEMSSRQAMLENASDIKLEK 308
+KK +++ E ER+ + E + + E R+ N + K E+
Sbjct: 149 RKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Score = 38.9 bits (89), Expect = 0.020
Identities = 19/68 (27%), Positives = 43/68 (63%), Gaps = 1/68 (1%)
Query: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQA-EKQTKEALTRKQQKCRRKNQDEESQEAP 599
++++KE + EK+++K KE K G+++K+ E++ KE R+++K R + ++E +E
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERE 159
Query: 600 ELLKRPKE 607
++ +E
Sbjct: 160 RKERKKRE 167
Score = 34.3 bits (77), Expect = 0.50
Identities = 21/82 (25%), Positives = 42/82 (51%), Gaps = 11/82 (13%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGG-----------KSTKQAEKQTKEALTRKQQK 585
+K ++K++E K+ E++E+K +E K G K K+ E+ KE +++K
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERK 203
Query: 586 CRRKNQDEESQEAPELLKRPKE 607
RR+ + E ++ +R K+
Sbjct: 204 ERRERKKERKKKEERKKERQKD 225
Score = 33.9 bits (76), Expect = 0.65
Identities = 16/67 (23%), Positives = 42/67 (62%), Gaps = 3/67 (4%)
Query: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
++K++ ++ K+E++ + + GK K+ E++ +E R+++K RR+ +++E +E +
Sbjct: 58 ERKKERREREKRKREREKERKRERGKKEKKGERKKEE---RERKKRRREKENKEGEEKEK 114
Query: 601 LLKRPKE 607
K+ K+
Sbjct: 115 RKKKEKK 121
Score = 32.3 bits (72), Expect = 1.9
Identities = 18/61 (29%), Positives = 37/61 (60%), Gaps = 2/61 (3%)
Query: 549 KQYEKQEKKLKELKAGGKSTKQA--EKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPK 606
K+ E++EK+ KE K ++ K+ E++ KE RK+++ +++ + +E Q+ + R K
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK 233
Query: 607 E 607
E
Sbjct: 234 E 234
Score = 31.2 bits (69), Expect = 4.2
Identities = 21/76 (27%), Positives = 43/76 (56%), Gaps = 5/76 (6%)
Query: 537 KKMYQQKQKELLKQYEKQEKKL----KELKAGGKSTKQAEKQTKE-ALTRKQQKCRRKNQ 591
K+ +K+K+ ++ E++E+K KE K G + K+ +K+ KE T K+ K R + +
Sbjct: 78 KRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE 137
Query: 592 DEESQEAPELLKRPKE 607
+ + +E E ++ +E
Sbjct: 138 ERKREERKERERKKEE 153
Score = 31.2 bits (69), Expect = 4.2
Identities = 19/72 (26%), Positives = 38/72 (52%), Gaps = 2/72 (2%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELK--AGGKSTKQAEKQTKEALTRKQQKCRRKNQDEE 594
KK + KE ++ K+E+K +E K K ++ E++ KE R++++ K ++ +
Sbjct: 120 KKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERK 179
Query: 595 SQEAPELLKRPK 606
+E E KR +
Sbjct: 180 EKERKERKKRER 191
Score = 31.2 bits (69), Expect = 4.2
Identities = 20/70 (28%), Positives = 39/70 (55%), Gaps = 5/70 (7%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
K+ ++K++E ++ K+E++ KE + K K+ E++ KE +QK R+ N E+ +
Sbjct: 181 KERKERKKRERNRKERKKERERKERRERKKERKKKEERKKE-----RQKDRQTNWREKER 235
Query: 597 EAPELLKRPK 606
E +R K
Sbjct: 236 GKRERKERKK 245
Score = 30.0 bits (66), Expect = 9.4
Identities = 23/74 (31%), Positives = 43/74 (58%), Gaps = 10/74 (13%)
Query: 541 QQKQKELLKQYEKQEK-------KLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDE 593
++++KE ++ E++EK K +E K G+ K+ E++ KE RK+++ RK + +
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGE--KEEERKEKERKERKKRERNRKERKK 198
Query: 594 ESQEAPELLKRPKE 607
E +E E +R KE
Sbjct: 199 E-RERKERRERKKE 211
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 73.2 bits (178), Expect = 1e-12
Identities = 65/274 (23%), Positives = 121/274 (44%), Gaps = 49/274 (17%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKD--------KKIKKTFFEELAVEDKQAGE 54
K+P+ + P E E+ SP+DK +K K +K K E+ +K+ +
Sbjct: 762 KSPEAKTPAKE-----EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 55 EEKV---LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDE 111
+E+V +KE+E+ Q+ + ++ KK + K ++ + K+ K+ P +E
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 112 EDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHP-PKPAKPEKNRINKAVSEEQQ 170
+ E KP+ K ++ + EE E+++K P P+ P K + + +++
Sbjct: 877 KKEPAVEKPKESK-----------VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK 925
Query: 171 PALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK------------------EKE 212
+ K+ + K+K +KP K A +++ KEE+ K KE
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKA 246
P K KA+KAE+ S + + + E+ E KA
Sbjct: 986 PSKP---KAEKAEKSSSTDQKDSKPPEKATEDKA 1016
Score = 67.4 bits (163), Expect = 5e-11
Identities = 65/248 (26%), Positives = 107/248 (43%), Gaps = 27/248 (10%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE---KEQQQQQQQQQQKKKRDTRKG 82
KVV+K +K+ I + EE V ++ EEEK KE KE++ ++++ + + +T+
Sbjct: 445 KVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504
Query: 83 RRKKDVDDDGEEKE-LMERLKKLSVPTSDEEDEVPAP-KPRGGKKTKGGNVFAALIQDQS 140
++ + E K + E K + S E++E +P + + +K K
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAK------------- 551
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE 200
+EE K PP+ PEK + K +E KS +AK K + EE
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE 611
Query: 201 EDKEEE----IIKEKEPPKQGK--EKAK---KAEQGSEEEGEGEEEEEEGGESKADDPYA 251
E + +E + P + K EKAK K E S E+ + E+EE KA P
Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVK 671
Query: 252 HLSKKEKK 259
+K +K
Sbjct: 672 AEAKSPEK 679
Score = 60.8 bits (146), Expect = 5e-09
Identities = 80/328 (24%), Positives = 133/328 (40%), Gaps = 42/328 (12%)
Query: 3 KAPKQQPPEPEWIGDGESTSPS---DKVVKKGKKDKKIKKTFFEELAVEDK-------QA 52
KA + P + + E+ SP V ++ K +K K EE +K +A
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEA 744
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
EK ++ + + + K + R D + + + E +K S +
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEE---KHPPKPAKPE------KNRINK 163
++ AP+ KK + + EEE+ +E K PPK A+ E K K
Sbjct: 805 EDAKAPEKEIPKKEE-------VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 164 AVSEEQQPALKGKKGKEEKSKGKA--KP-QNKFAALDNEEEDKEEEIIKEKEPPK--QGK 218
+E+ P + K K E+ K A KP ++K A E EDK++ EKE P + K
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917
Query: 219 EKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKK----EKKKLKKQMEYERQVASL 274
E AK E + E ++E ++KA +P KK EKK K++ + +
Sbjct: 918 EDAKPKE-------KTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPK 970
Query: 275 KAANAAENDFSVSQAEMSSRQAMLENAS 302
A A E+D ++S+ + E +S
Sbjct: 971 TEAKAKEDDKTLSKEPSKPKAEKAEKSS 998
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/246 (21%), Positives = 101/246 (41%), Gaps = 5/246 (2%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDK-QAGEEEKVLKEKEQQQQQQQQQQKKKR 77
E T +++V ++ +K+ K ++ EE E++ + GEEE E+ +++ + +
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVK 521
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
+ K + + E K E + +E+ P+ + +K + +
Sbjct: 522 EEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSP 581
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE-KSKGKAKPQNKFAAL 196
++++ +EE P AK + + E + PA KEE KS + K K +
Sbjct: 582 EKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAK---KAEQGSEEEGEGEEEEEEGGESKADDPYAHL 253
EE E+ ++ + EKAK KAE S E+ + + E KA P
Sbjct: 642 TKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEE 701
Query: 254 SKKEKK 259
+K +K
Sbjct: 702 AKSPEK 707
Score = 55.5 bits (132), Expect = 2e-07
Identities = 75/306 (24%), Positives = 124/306 (40%), Gaps = 35/306 (11%)
Query: 3 KAPKQ--QPPEPEWIGDGESTSPSDKVVKKG---KKDKKIKKTFFEELAVEDKQAGEEEK 57
K+P++ P + E E+ SP + K K +K K EE +K E++
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Query: 58 VLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
K E+ + + + K + + + + + + E K S ++E +
Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKS 718
Query: 118 PKPRGGKKTKGGNVFAALIQDQSEEE-EEEEKHPPKPAKPEKNRI---------NKAVSE 167
P+ K K A ++++ +EE K P K PEK + A E
Sbjct: 719 PE-----KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEE 773
Query: 168 EQQPA------LKGKKGKEEKSKGKAK-PQNKFAALDNEEEDKEEEI---IKEKEPPKQ- 216
+ PA K +E KS KAK P + A +E K+EE+ +KE+E P++
Sbjct: 774 ARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833
Query: 217 -GKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLK 275
KE KKAE EE+ + EE +SK ++ + K K + KK+ E+ S
Sbjct: 834 KVKEPPKKAE---EEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV 890
Query: 276 AANAAE 281
A E
Sbjct: 891 EAKKEE 896
Score = 53.5 bits (127), Expect = 8e-07
Identities = 40/120 (33%), Positives = 62/120 (51%), Gaps = 12/120 (10%)
Query: 176 KKGKEEKSKGKAKPQNKFAALDNEEEDKE--EEIIKEKEPPKQGKEKAKKAEQGSEEEGE 233
K EEK K K + + ++ + E+ + EE+ +E+E K K E+G EEEG
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEE-------KEAKEEEGKEEEG- 488
Query: 234 GEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSS 293
GEEEE EGGE + P A + +K+ K ++ E + S A + E + + S AE+ S
Sbjct: 489 GEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAK--SPAEAKSPEKEEAKSPAEVKS 546
Score = 53.1 bits (126), Expect = 1e-06
Identities = 59/272 (21%), Positives = 101/272 (37%), Gaps = 15/272 (5%)
Query: 3 KAP-KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
K+P K++ P + E K K + K + + E K E + +KE
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
+ + + + +K K T++ K EKE + +K P E K
Sbjct: 625 EAKSPAEVKSPEKAKSPTKE-EAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK--GK 179
+ K + ++++++ E+ K P K + V EE + K K +
Sbjct: 684 VKAEAKSPEKAKSPVKEEAKSPEKA-KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE 742
Query: 180 EEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEE 239
E KS KAK K LD +K E KE+A+ E+ + +EE
Sbjct: 743 EAKSPEKAKSPEKAKTLD----------VKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 240 EGGESKADDPYAHLSKKEKKKLKKQMEYERQV 271
KA P +K +K++ K+ E + V
Sbjct: 793 VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824
Score = 51.6 bits (122), Expect = 3e-06
Identities = 65/289 (22%), Positives = 111/289 (38%), Gaps = 42/289 (14%)
Query: 10 PEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQ 69
P P + +G PS K K ++KIK + E+E V+ E EQ ++ Q
Sbjct: 417 PIPFSLPEGLPKIPSVSTHIKVKSEEKIKVV----------EKSEKETVIVE-EQTEETQ 465
Query: 70 QQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGG 129
++ + + ++ + ++ +++G E+E E EE+ P K
Sbjct: 466 VTEEVTEEEEKEAKEEEGKEEEGGEEEEAE---------GGEEETKSPPAEEAASPEK-- 514
Query: 130 NVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKP 189
+ +EE K P + PEK + K +E KS +AK
Sbjct: 515 --------EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566
Query: 190 QNKFAALDNEEEDKEEEIIKEKEPPKQ-GKEKAKK-AEQGSEEEGEGEEEEEEGGESKAD 247
K EE K +K E K KE+AK AE S E+ + +EE ++A
Sbjct: 567 PEK-------EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAK 619
Query: 248 DPYAHLSK---KEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSS 293
P +K + K K + + + S + A + E + + S + S
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668
Score = 49.3 bits (116), Expect = 1e-05
Identities = 55/278 (19%), Positives = 107/278 (38%), Gaps = 7/278 (2%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ 65
+++ E E GE + S + +K+ K EE + E++ K +
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEV 544
Query: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP-KPRGGK 124
+ ++ + K + + K + EE + +K S ++E +P + + +
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAKSPEK--EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE 602
Query: 125 KTKGGNVFAALIQDQSEEEEEEEKHPPKPAK-PEKNRINKAVSEEQQPALKGKKGKEEKS 183
K K A +++ +EE P K PEK + EE + K K ++E++
Sbjct: 603 KAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAK--SPTKEEAKSPEKAKSPEKEEA 660
Query: 184 KGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGE 243
K K ++ A E + + E + P++ K K+ E S E+ + +EE
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE-EAKSPEKAKSPVKEEAKSP 719
Query: 244 SKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAE 281
KA P +K +K E + K+ A+
Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Score = 47.0 bits (110), Expect = 7e-05
Identities = 46/196 (23%), Positives = 87/196 (44%), Gaps = 16/196 (8%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
P+ K + P + + +P + K KK++ KK + E K+ E+ KE
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP--KE 887
Query: 62 KEQQQQQQQQQQKKKRDT--RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPK 119
+ + ++++ + KKK T ++ K +V +D + KE E KK +E PA K
Sbjct: 888 SKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEK 947
Query: 120 PRGGKKTKGGNVFAALIQDQS--------EEEEEEEKHPPKPAKPEKNRINKAVSEEQQP 171
+ K A ++ E+++ K +P+KP+ + K+ S +Q+
Sbjct: 948 KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK---EPSKPKAEKAEKSSSTDQKD 1004
Query: 172 ALKGKKGKEEK-SKGK 186
+ +K E+K +KGK
Sbjct: 1005 SKPPEKATEDKAAKGK 1020
Score = 30.8 bits (68), Expect = 5.5
Identities = 21/76 (27%), Positives = 41/76 (53%), Gaps = 10/76 (13%)
Query: 544 QKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE--- 600
+KE +K K+E+K +E+K + K+AE++ A + ++K K ++ +EAP+
Sbjct: 816 KKEEVKSPVKEEEKPQEVKV-KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKV 874
Query: 601 ------LLKRPKEYTV 610
+++PKE V
Sbjct: 875 EEKKEPAVEKPKESKV 890
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/245 (19%), Positives = 127/245 (51%), Gaps = 28/245 (11%)
Query: 44 ELAVEDKQAGEEEKVLKEKEQQQQQQQQQ------QKKKRDTRKGRRKKDVDDDGEEKEL 97
++ ++ Q GE+E+ + E+E+Q Q+Q++Q Q +K++ + G +++ V E+ +
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK 252
Query: 98 ME-RLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKP 156
E +++K ++E+++ + + K+ + ++Q+ E+EE+ + + +
Sbjct: 253 QEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ-----EEQTGEQEEQMREQEEQMRE 307
Query: 157 EKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQ------------NKFAALDNEEEDKE 204
++ ++ + EEQ + + GK+E+ + K Q + + + + +E
Sbjct: 308 QEEQMRE--QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQE 365
Query: 205 EEIIKEKEPPKQGKEKAKKAEQ--GSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLK 262
E++ K++E ++ +E+ +K E+ +EE GE++E+ G + + ++K++++
Sbjct: 366 EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Query: 263 KQMEY 267
KQ E+
Sbjct: 426 KQEEH 430
Score = 62.0 bits (149), Expect = 2e-09
Identities = 45/246 (18%), Positives = 123/246 (50%), Gaps = 19/246 (7%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
M + +Q + E +G+ E + + G+++++++K + E++ +EE++ +
Sbjct: 208 MGEQEEQMQKQEEQMGEQEEQMRKQEE-QMGEQEEQVQKQEEQVQKQEEQMRKQEEQMRE 266
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
++EQ ++Q++Q K+K T + + + ++ E+E E++++ ++E+++ +
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE--EQMREQEEQMREQEEQMREQEE 324
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ GK+ EE+ E+K K + + + + E+++ K ++
Sbjct: 325 QMGKQ---------------EEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVR 369
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK-KAEQGSEEEGEGEEEEE 239
++ + K + + + + +EE++ ++KE + KE+ + + EQ E++ + ++EE
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Query: 240 EGGESK 245
GE K
Sbjct: 430 HMGEQK 435
Score = 59.3 bits (142), Expect = 1e-08
Identities = 45/234 (19%), Positives = 122/234 (52%), Gaps = 15/234 (6%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELM----ERLKK 103
++ Q E+E ++E+E Q ++Q+ Q +++ +G+ + GE++E M E+++K
Sbjct: 162 QEGQVREQEGQVREQEGQVREQEGQVREQ----EGQMGEQEGQMGEQEEQMGEQEEQMQK 217
Query: 104 LSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEE---EEEEEKHPPKPAKPEKNR 160
++E+++ + + G++ + +Q Q E+ +EE+ + + + ++ +
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQ 277
Query: 161 INKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE--DKEEEIIKEKEPPKQGK 218
+ K + +Q G++ ++ + + + + + + EE+ ++EE++ K++E + K
Sbjct: 278 MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQK 337
Query: 219 EK--AKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
E+ +K + +EE GE+EE+ + + +K++++++KQ E R+
Sbjct: 338 EQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK 391
Score = 55.1 bits (131), Expect = 3e-07
Identities = 48/273 (17%), Positives = 131/273 (47%), Gaps = 10/273 (3%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK 85
K +K+ + KI ++ ++ Q E+E ++E+E Q ++Q+ Q +++ + +
Sbjct: 35 KELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 94
Query: 86 KDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEE 145
+ + +G+ +E ++++ ++E +V + G + + G V Q + +E +
Sbjct: 95 QVREQEGQVREQEGQVREQEGQVREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQV 152
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK-AKPQNKFAALDNEEEDKE 204
E+ + + R + EQ+ ++ ++G+ + +G+ + + + + + ++E
Sbjct: 153 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
Query: 205 EEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQ 264
E++ K++E + +E+ +K +EE GE+EE+ + + +K+++++++Q
Sbjct: 213 EQMQKQEEQMGEQEEQMRK-----QEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQ 267
Query: 265 MEY--ERQVASLKAANAAENDFSVSQAEMSSRQ 295
E E++ LK E + + E R+
Sbjct: 268 EEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Score = 53.5 bits (127), Expect = 8e-07
Identities = 44/256 (17%), Positives = 119/256 (46%), Gaps = 9/256 (3%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 64 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 123
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
++E +V + G + + G V Q + +E + E+ + + R +
Sbjct: 124 VREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 181
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG 227
EQ+ ++ ++G+ + +G+ Q + E+ K+EE + E+E ++ K+ EQ
Sbjct: 182 EQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE-----EQMRKQEEQM 236
Query: 228 SEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVS 287
E+E + +++EE+ K ++ ++ +++ ++ E E Q+ K E
Sbjct: 237 GEQEEQVQKQEEQ--VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Query: 288 QAEMSSRQAMLENASD 303
+ +M ++ + +
Sbjct: 295 EEQMREQEEQMREQEE 310
Score = 52.4 bits (124), Expect = 2e-06
Identities = 39/236 (16%), Positives = 114/236 (48%), Gaps = 20/236 (8%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 179
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKN--RINKAV 165
++E +V + + G+ + + E+EE+ +K + + E+ + + +
Sbjct: 180 VREQEGQV---REQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQM 236
Query: 166 SEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAE 225
E+++ K ++ +++ + K + + + + ++EE+++K+KE +Q ++ ++ E
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEE 296
Query: 226 QGSEEEGE---------------GEEEEEEGGESKADDPYAHLSKKEKKKLKKQME 266
Q E+E + E+EE+ G + + ++K+++ KQ E
Sbjct: 297 QMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEE 352
Score = 51.2 bits (121), Expect = 4e-06
Identities = 44/253 (17%), Positives = 116/253 (45%), Gaps = 6/253 (2%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
EEL ++ + EE ++++ ++ + Q ++ K+K +T K + +G+ +E +++
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDK----IPLPQEGQVREQEGQVR 62
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
+ ++E +V + G + + G V Q + +E + E+ + + R
Sbjct: 63 EQEGQVREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
+ EQ+ ++ ++G+ + +G+ + Q + ++E ++E+E + +E
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 180
Query: 223 KAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAEN 282
+ ++G E EG+ E+EG + ++ ++ +K+ ++ E E Q+ + +
Sbjct: 181 REQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQE 240
Query: 283 DFSVSQAEMSSRQ 295
+ Q E +Q
Sbjct: 241 EQVQKQEEQVQKQ 253
Score = 51.2 bits (121), Expect = 4e-06
Identities = 46/255 (18%), Positives = 122/255 (47%), Gaps = 18/255 (7%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 78 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 137
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
++E +V + G + + G V + Q E+E + + + ++ ++ + E
Sbjct: 138 VREQEGQVR--EQEGQVREQEGQVREQ--EGQVREQEGQVREQEGQVREQEGQVRE--QE 191
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE---DKEEEIIKEKEPPKQGKEKAKKA 224
Q +G+ G++E+ G+ + Q + +EE ++EE++ K++E + +E+ +K
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQ-----MQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246
Query: 225 EQGSEEEGEG----EEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAA 280
E+ +++ E EE+ E E + L +KE+ + ++Q + + +
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 281 ENDFSVSQAEMSSRQ 295
E + + + E R+
Sbjct: 307 EQEEQMREQEEQMRE 321
Score = 47.4 bits (111), Expect = 6e-05
Identities = 45/264 (17%), Positives = 121/264 (45%), Gaps = 9/264 (3%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVP 107
++ Q E+E ++E+E Q ++Q+ Q +++ + + + + +G+ +E ++++
Sbjct: 106 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 165
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVF---AALIQDQSEEEEEEEKHPPKPAKPEKNRINKA 164
++E +V + G + + G V + + + + E+EE+ + + +K
Sbjct: 166 VREQEGQVR--EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMG 223
Query: 165 VSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKA 224
EEQ + + G++E+ K + Q E+ K+EE ++E+E + +E+ +
Sbjct: 224 EQEEQMRKQEEQMGEQEEQVQKQEEQ---VQKQEEQMRKQEEQMREQEEQMREQEE-QML 279
Query: 225 EQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDF 284
+Q + E E + E+E + ++ ++ +++ ++ E E Q+ + + +
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQ 339
Query: 285 SVSQAEMSSRQAMLENASDIKLEK 308
Q E +Q + +++K
Sbjct: 340 MWEQKEQMWKQEEQMGEQEEQMQK 363
Score = 35.0 bits (79), Expect = 0.29
Identities = 17/67 (25%), Positives = 44/67 (65%), Gaps = 2/67 (2%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ--QQQQQQQQQKKKRDTRKGRRKKDVD 89
K++++++K + E++ +EE++ ++KEQ +Q++Q ++Q+++ +K + +K +
Sbjct: 370 KQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEE 429
Query: 90 DDGEEKE 96
GE+KE
Sbjct: 430 HMGEQKE 436
Score = 34.3 bits (77), Expect = 0.50
Identities = 20/72 (27%), Positives = 42/72 (58%), Gaps = 6/72 (8%)
Query: 542 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRR----KNQDEESQE 597
QKQ+E + + E+Q +K +E G+ +Q +KQ ++ +++Q ++ + Q+E+ +E
Sbjct: 216 QKQEEQMGEQEEQMRKQEEQM--GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Query: 598 APELLKRPKEYT 609
E + + KE T
Sbjct: 274 QEEQMLKQKEQT 285
Score = 33.1 bits (74), Expect = 1.1
Identities = 19/69 (27%), Positives = 40/69 (57%), Gaps = 2/69 (2%)
Query: 542 QKQKELLKQYEKQEKKLKEL--KAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAP 599
QKQ+E +++ E+Q +K +E K + KQ E+ ++ +QK + + Q+E+ E
Sbjct: 362 QKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQK 421
Query: 600 ELLKRPKEY 608
E +++ +E+
Sbjct: 422 EQMRKQEEH 430
Score = 32.3 bits (72), Expect = 1.9
Identities = 17/67 (25%), Positives = 40/67 (59%), Gaps = 1/67 (1%)
Query: 542 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTR-KQQKCRRKNQDEESQEAPE 600
+KQ+E +++ E+Q ++ +E K + E+QT E + ++Q+ + + Q+E+ +E E
Sbjct: 258 RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEE 317
Query: 601 LLKRPKE 607
++ +E
Sbjct: 318 QMREQEE 324
Score = 31.6 bits (70), Expect = 3.2
Identities = 13/71 (18%), Positives = 42/71 (59%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
++ Q++++++ KQ E+ K+ ++++ + ++ E+Q + + +Q+ + Q+E+ +
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 597 EAPELLKRPKE 607
E E ++ +E
Sbjct: 300 EQEEQMREQEE 310
Score = 31.2 bits (69), Expect = 4.2
Identities = 17/71 (23%), Positives = 46/71 (64%), Gaps = 7/71 (9%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
++M++QK++ +E++E+ K+ + G+ +Q +KQ ++ RKQ++ + + Q+E+ +
Sbjct: 331 EQMWEQKEQ----MWEQKEQMWKQEEQMGEQEEQMQKQEEQV--RKQEE-QMRKQEEQMR 383
Query: 597 EAPELLKRPKE 607
+ E +++ +E
Sbjct: 384 KQEEQMRKQEE 394
Score = 30.8 bits (68), Expect = 5.5
Identities = 12/71 (16%), Positives = 43/71 (60%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
++ Q++++++ KQ E+ ++ ++++ + + ++QT++ +Q+ + + Q+E+ +
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 597 EAPELLKRPKE 607
E E ++ +E
Sbjct: 307 EQEEQMREQEE 317
Score = 30.0 bits (66), Expect = 9.4
Identities = 12/66 (18%), Positives = 40/66 (60%)
Query: 542 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPEL 601
++++++ KQ E+ +K+ ++++ + ++ E+Q +E + ++ + Q+E++ E E
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 602 LKRPKE 607
++ +E
Sbjct: 298 MREQEE 303
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 68.2 bits (165), Expect = 3e-11
Identities = 62/267 (23%), Positives = 131/267 (49%), Gaps = 26/267 (9%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR-------- 83
+KDKK+++ + L E ++ +E+ K +E+++ QQ+++Q + + K R
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020
Query: 84 RKKDVDDDGEEKELMERLKKLSVPTSD----EEDEVPAPKPR---GGKKTKGGNVFAALI 136
RKKD EE+ L E +K + + EE+E+ + + ++T+
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY 1080
Query: 137 QDQSEEEEEEE----KHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNK 192
+ + E ++EEE + P K + E+ R + E QQ + + +EE+ K + + +
Sbjct: 1081 RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE--EEQLLREEREKRRRQELER 1138
Query: 193 FAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEE----EEEEGGESKADD 248
+ E + +EE++++E EP K+ +++ ++ + EE + EE EE+E + +
Sbjct: 1139 QYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Query: 249 PYAHLSKKEKKKLKKQMEYERQVASLK 275
Y + +++K K++ E Q + LK
Sbjct: 1198 QYREEEELQRQKRKQRYRDEDQRSDLK 1224
Score = 65.9 bits (159), Expect = 2e-10
Identities = 65/311 (20%), Positives = 151/311 (48%), Gaps = 49/311 (15%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK-EKEQ 64
++Q +W+ E T ++ +K +++K+ D++ E+ LK E+E+
Sbjct: 449 REQEERRDWLKREEETERHEQERRK----QQLKR---------DQEEERRERWLKLEEEE 495
Query: 65 QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGK 124
+++QQ++++++ R ++ RR++ + EE+ L +RL+ ++E+ R +
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 125 KTKGGNVFAALIQDQSEE--EEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
K L Q++ E+ + E+E+ + K E+ R + + EQ+ L+ + +EE
Sbjct: 556 KR--------LEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV 607
Query: 183 SKGKAKPQNKFAALDNE-EEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEG 241
+ + + + + E EE++ ++++K +E ++ +++ ++ +Q E+ EEEEE
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE- 666
Query: 242 GESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSR----QAM 297
+ +++LK++ E ER+ L AE + ++ + SR Q
Sbjct: 667 --------------RLEQRLKREHEEERREQEL-----AEEEQEQARERIKSRIPKWQWQ 707
Query: 298 LENASDIKLEK 308
LE+ +D + K
Sbjct: 708 LESEADARQSK 718
Score = 61.2 bits (147), Expect = 4e-09
Identities = 54/279 (19%), Positives = 146/279 (52%), Gaps = 28/279 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
++ +++ +++K+ ++ + E++ EEE++L+E+ +++++Q+++++ ++D + ++
Sbjct: 910 EEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 85 KKDV-DDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE 143
++ + ++ E++ ER KK +++E + K+ + +D+ ++E
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE 1029
Query: 144 EE----EEKHPPKPAKPEKN-RINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
EE EE+ + + E+ R + + +E++ L G+E +++ + + + ++ +
Sbjct: 1030 EEQLLREEREKRRLQERERQYREEEELQQEEEQLL----GEERETRRRQELERQYRK-EE 1084
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEK 258
E + +EE++++E EP K+ + ++ E+ EE E ++EEE+ L ++E+
Sbjct: 1085 ELQQEEEQLLRE-EPEKR---RRQERERQCREEEELQQEEEQ------------LLREER 1128
Query: 259 KKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAM 297
+K ++Q E ERQ + E + E RQ +
Sbjct: 1129 EKRRRQ-ELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Score = 60.1 bits (144), Expect = 8e-09
Identities = 108/628 (17%), Positives = 261/628 (41%), Gaps = 102/628 (16%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVK---KGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K+Q E E + +GE S + ++ + ++D+++ + E E+++A EE+ +
Sbjct: 140 KRQEQERE-LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERL---------KKLSVPTSDEED 113
+ ++ ++Q ++R+ + RRK + + +E +R+ +K EE+
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 114 EVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPAL 173
++ +P+ ++ +Q++ E+ + E+ + + E+ + + + EQQ
Sbjct: 259 KLQEEEPQRQRE----------LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 174 KGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGE 233
K ++ + E+ + + + Q + + +EE +E+++ +E+E ++ + + ++ E+ E++
Sbjct: 309 KQEEERREQQEERREQQER---REQQEERREQQLRREQEERREQQLRREQEEERREQQLR 365
Query: 234 GEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSS 293
E+EEE + L ++++ + ++Q+ E+Q L+ + + + +
Sbjct: 366 REQEEERREQ--------QLRREQQLRREQQLRREQQ---LRREQQLRREQQLRREQQLR 414
Query: 294 RQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRA 353
R+ L ++ E+ R+ + + L + R
Sbjct: 415 REQQLRREQQLRREQ-------------------EEERHEQKHEQERREQRLKREQEERR 455
Query: 354 LSIPPNIDVLLCEQEVVADETPAVQAVLRADTKR------LKLLEEERRLQGQ------L 401
D L E+E E + L+ D + LKL EEERR Q +
Sbjct: 456 -------DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 402 EQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVS 461
+ ++ +RL++ EE R +E + RR E + R Q R+
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQLRR---------EQEERREQLLKREEEKRLE 559
Query: 462 LARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHL 521
R E L E L + R+ + + L+ +
Sbjct: 560 QER---REQRLKREQEERRDQLLKR--------EEERRQQRLKREQEERLEQ---RLKRE 605
Query: 522 DAQRLHYYRGNYMTFKKMYQQKQK--ELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEAL 579
+ +RL K+ ++++ +LLK E++E++ ++L+ + ++ + +E
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE 665
Query: 580 TRKQQKCRRKNQDEESQEAPELLKRPKE 607
R +Q+ +R++++E ++ EL + +E
Sbjct: 666 ERLEQRLKREHEEERREQ--ELAEEEQE 691
Score = 60.1 bits (144), Expect = 8e-09
Identities = 53/235 (22%), Positives = 121/235 (51%), Gaps = 26/235 (11%)
Query: 54 EEEKVLKEKEQQQQQQQ--QQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDE 111
+ E+ L+ +E+QQ++Q+ ++++K R+ RR+++ + E+E + ++ + +E
Sbjct: 793 QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEE 852
Query: 112 EDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHP--PKPAKPEKNRINKAVSEEQ 169
ED + + R + + + + Q EEE + +H KPA E+ R + + +E+
Sbjct: 853 EDGLQEDQERRRSQEQRRD---QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 170 QPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK-----KA 224
+ L+ +EE+ K + + Q + + + + +EE++++E+ ++ +E+ + K
Sbjct: 910 EEELQ----REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Query: 225 EQGSEEEGEGEE---------EEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
Q EE+ GEE E++ E + L ++E++K ++Q E+ERQ
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ-EWERQ 1019
Score = 57.8 bits (138), Expect = 4e-08
Identities = 56/268 (20%), Positives = 127/268 (47%), Gaps = 31/268 (11%)
Query: 38 KKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKD--VDDDGEEK 95
K E+L E + EEE+ L+ +E++++++Q+Q+++ R+ + +++++ + ++ E++
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR 951
Query: 96 ELMERLK--KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE----EEEEKH 149
ER + + +E+++ +P ++ + + + Q EEE EE EK
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 150 PPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK 209
+ + + + ++ EE+Q +EE+ K + + + E + +EEE ++
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLL------REEREKRRLQ--------ERERQYREEEELQ 1057
Query: 210 EKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYER 269
++E G+E+ + Q E + EEE ++ E L ++E +K ++Q E ER
Sbjct: 1058 QEEEQLLGEERETRRRQELERQYRKEEELQQEEE--------QLLREEPEKRRRQ-ERER 1108
Query: 270 QVASLKAANAAENDFSVSQAEMSSRQAM 297
Q + E + E RQ +
Sbjct: 1109 QCREEEELQQEEEQLLREEREKRRRQEL 1136
Score = 57.0 bits (136), Expect = 7e-08
Identities = 47/244 (19%), Positives = 121/244 (49%), Gaps = 22/244 (9%)
Query: 49 DKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPT 108
D++ EEE++L+E E+QQ ++Q++ +K R+ + R+++ + ++E R ++L
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725
Query: 109 SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEE 168
+EE + ++ + + +++++ E EE+ + + K R + + +E
Sbjct: 1726 REEEQ---LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQE 1782
Query: 169 -QQPALKGKKG----------KEEKSKGKAKPQNKFAALDNEE-----EDKEEEIIKEKE 212
++ L+ ++ ++E+ + + +PQ + EE E++E+ + +E++
Sbjct: 1783 REEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVA 272
+ +E+ E+ EE E +EEE + + + L ++ ++ +K+ + RQV
Sbjct: 1843 RQYRAEEQFATQEKSRREEQELWQEEE---QKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
Query: 273 SLKA 276
+K+
Sbjct: 1900 EIKS 1903
Score = 55.1 bits (131), Expect = 3e-07
Identities = 47/277 (16%), Positives = 137/277 (49%), Gaps = 23/277 (8%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
++ +++++ + EE E+ Q EE+ + +E+E+++Q++++Q +++ + ++ +RK+ D+
Sbjct: 1161 RRRQELERQYREE---EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 92 GEEKEL---MERLKKLSVPTSD------EEDEVPAPKPRGGKKTKGGNVFAALIQDQSEE 142
+ +L E K+ +V + E ++ + + + L+ +Q E
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 143 EEEEEKHPPKPAK---PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNE 199
+ E+E+ + PE+ ++ + E+++ + +K +EEK + + + K + +
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLER--EEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 200 EEDKEEE-IIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEK 258
+ +EEE +++E+E ++ ++ E+ + E +E+G + ++ ++E+
Sbjct: 1336 RKFREEEQLLQERE-----EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 259 KKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQ 295
K LK++ + Q + + F + ++S ++
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Score = 53.9 bits (128), Expect = 6e-07
Identities = 50/252 (19%), Positives = 116/252 (46%), Gaps = 42/252 (16%)
Query: 31 GKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ------QQQQQQQQKKKRDTRKGRR 84
G ++K + +E ++D++ E+++ + +++Q Q+++Q++Q+++R+ +G
Sbjct: 94 GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE- 152
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
E+ E ERL++ DEE Q Q +E
Sbjct: 153 --------EQSEKQERLEQRDRQRRDEE---------------------LWRQRQEWQER 183
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPALK-----GKKGKEEKSKGKAKPQNK-FAALDN 198
EE + + + K + +E+Q + +KG+EEK + + + Q++ F +
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEK 258
+E K E +++++E Q +E ++ E EEE + E +E + ++ + +
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 259 KKLKKQMEYERQ 270
++L+++ E ER+
Sbjct: 304 QQLRRKQEEERR 315
Score = 53.9 bits (128), Expect = 6e-07
Identities = 49/260 (18%), Positives = 130/260 (50%), Gaps = 37/260 (14%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
E ++ +K+ ++++++++ E + +Q E++LK +E+++ +Q++++++ +
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569
Query: 79 TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQD 138
++ RR + + + E ++ +RLK+ E++E R ++ K V +
Sbjct: 570 EQEERRDQLLKREEERRQ--QRLKR-------EQEE------RLEQRLKREEV------E 608
Query: 139 QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN 198
+ E+EE E+ + E+ R SEEQ+ + + +E++ + + + + +
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR-----EE 663
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGE--------EEEEEGGESKADDPY 250
EEE E+ + +E E ++ +E A++ ++ + E + E E + +SK Y
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV---Y 720
Query: 251 AHLSKKEKKKLKKQMEYERQ 270
+ K+E ++ +++ E +R+
Sbjct: 721 SRPRKQEGQRRRQEQEEKRR 740
Score = 53.5 bits (127), Expect = 8e-07
Identities = 66/322 (20%), Positives = 146/322 (45%), Gaps = 41/322 (12%)
Query: 48 EDKQAGEEE---KVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKEL--MERLK 102
E++Q +E K L+E+ Q ++Q+++QQ + RK R ++ + +GEE++L ER +
Sbjct: 1632 EEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
K +EE ++ + + + ++ + EEE+ + + + R
Sbjct: 1692 KF----REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAK 222
K + EEQ + +EE+ + + KF + +++EE+ ++ +E ++ +E+ +
Sbjct: 1748 KILEEEQL-----RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQ 1802
Query: 223 KAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKE---KKKLKKQMEYERQVASLKAANA 279
++ E++ ++ + G+ + ++ L ++E +++ +Q E Q A+ + +
Sbjct: 1803 LRQEREEQQLRPQQRD---GKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 280 AENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVG--- 336
E + + Q E R+ E KL + I KE +R+ VG
Sbjct: 1860 EEQE--LWQEEEQKRRQERER----KLREEHIRRQQKE-----------EQRHRQVGEIK 1902
Query: 337 -PNGKGKTTLLKHIANRALSIP 357
GKG LL+ ++ S+P
Sbjct: 1903 SQEGKGHGRLLEPGTHQFASVP 1924
Score = 53.1 bits (126), Expect = 1e-06
Identities = 58/286 (20%), Positives = 135/286 (47%), Gaps = 42/286 (14%)
Query: 13 EWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQA--------GEEEKVLKEKEQ 64
+W + E+ +KV KG+++++ ++ E+ + D+Q+ GE+++ +E+E+
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQ--LEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283
Query: 65 QQQQQ--------------QQQQKKKRDTRKGRRKKDVDDDGEEK---ELMERLKKLSVP 107
++ QQ +Q++ K+RD + K+ + ++ EEK + +R +
Sbjct: 1284 RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQ 1343
Query: 108 TSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
E +E P + +K + + Q+Q + EEE+ + + R K + E
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRH---QEQGRKFLEEEQRLRR-----QERERKFLKE 1395
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKK---A 224
EQQ + ++ + + + + K + + L +E D++ +E+E + +E+ +K
Sbjct: 1396 EQQLRCQEREQQLRQDRDR-KFREEEQQLSRQERDRK---FREEEQQVRRQERERKFLEE 1451
Query: 225 EQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
EQ +E + EEE + ++ H ++++K L+++ + RQ
Sbjct: 1452 EQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Score = 52.4 bits (124), Expect = 2e-06
Identities = 52/281 (18%), Positives = 129/281 (45%), Gaps = 60/281 (21%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
+ L E+ + +++LK +EQ++++QQQ ++++++ R+ R K++ EE+ L +RLK
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREE----EEERLEQRLK 673
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKG-----------------GNVFAA--LIQDQSEEE 143
+ E++ + + ++ K V++ + Q +
Sbjct: 674 REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQ 733
Query: 144 EEEEKHPPKPAK---PEKNRINKAVSEEQQ------------------------PALKGK 176
E+EEK + ++ E+ R ++ EE+Q P L+ +
Sbjct: 734 EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQ 793
Query: 177 KGKEEKSKGKAKPQNKFAALDNEEE-------DKEEEI-IKEKEPPKQGKEKAKKAEQGS 228
+ ++ +++ + + + +F + E+E ++E+E+ E+E Q +E+A++ ++
Sbjct: 794 RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE-- 851
Query: 229 EEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYER 269
EE+G E++E + + D +E++K ++ Y +
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/263 (21%), Positives = 114/263 (43%), Gaps = 22/263 (8%)
Query: 50 KQAGEEEKVLKEKEQ----QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLS 105
+Q EEE L+E ++ Q+Q++ Q+ + + + + RR+ + + L E+L+K
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL---YAKPALQEQLRKEQ 903
Query: 106 VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE----EEEEKHPPKPAKPEKNRI 161
+EE+E+ + ++ + + Q Q EEE EE EK + + + +
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 162 NKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKA 221
K +E+Q L G++ ++ + + + K + L EEE E +++ + ++
Sbjct: 964 KKLQQKEEQ--LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYR 1021
Query: 222 KKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSK---------KEKKKLKKQMEYERQVA 272
KK E EEE EE E+ + + Y + E+++ +++ E ERQ
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 273 SLKAANAAENDFSVSQAEMSSRQ 295
+ E + E RQ
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQ 1104
Score = 52.0 bits (123), Expect = 2e-06
Identities = 53/275 (19%), Positives = 130/275 (47%), Gaps = 28/275 (10%)
Query: 8 QPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQ 67
Q E + +G+ T ++ ++ +K++++++ + L E ++ +E+ + +E+++
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 68 QQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK 127
QQ+++Q + + K RR++ EE+E+ + EE+++ +P ++ +
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQ-----------EEEQLLREEPEKRRRQE 1165
Query: 128 GGNVFAALIQDQSEEE----EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKS 183
+ + Q EEE EE+EK + E+ R + E Q+ K + E++
Sbjct: 1166 LERQYREEEELQQEEEQLLREEQEKR-----RQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 184 ---KGKAKPQNKFAALDNEE--EDKEEEIIKEKEPPKQGKEKAKKAEQ---GSEEEGEGE 235
K + +P+ + A DN+ + +E E ++ E + ++++ Q G ++E + E
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE 1280
Query: 236 EEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
+E + P ++E++K K+ + + Q
Sbjct: 1281 QERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/271 (14%), Positives = 132/271 (48%), Gaps = 13/271 (4%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ 65
++Q E ++ E ++++++ ++ +++++ + E+ Q EE+ + +E+E +
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETR 1071
Query: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKK 125
++Q+ ++Q +K + + ++ + ++ E++ ER ++ +++E + K+
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131
Query: 126 TKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK-GKEEKSK 184
+ + +++ ++EEE+ +P K + + + EE++ + ++ +EE+ K
Sbjct: 1132 RR-QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Query: 185 GKAKPQNKFAALDN----------EEEDKEEEIIKEKEPPKQGKEKAKKAE-QGSEEEGE 233
+ + + ++ + +ED+ ++ + EP K+ + K +G E E
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 234 GEEEEEEGGESKADDPYAHLSKKEKKKLKKQ 264
+ E+ + + ++ HL +++++ ++Q
Sbjct: 1251 RQLEDSQLRDRQSQQDLQHLLGEQQERDREQ 1281
Score = 47.8 bits (112), Expect = 4e-05
Identities = 46/246 (18%), Positives = 120/246 (48%), Gaps = 26/246 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
++ V++ ++++K + + ++ EEE++L+E+E+QQ +Q++ +K + + R
Sbjct: 1436 EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
+++ D E+EL R ++ +EE ++ + Q + +EE
Sbjct: 1496 RQERDRKFREQEL--RSQEPERKFLEEEQQLHRQQR----------------QRKFLQEE 1537
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKE 204
++ + + + ++R K EEQ ++ +EE+ + + KF L+ ++ ++
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQL-----RQEREEQQLSRQERDRKF-RLEEQKVRRQ 1591
Query: 205 EEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQ 264
E+ K E +Q + ++ +Q +E + + E+E + ++ H ++++K L+++
Sbjct: 1592 EQERKFMEDEQQ--LRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649
Query: 265 MEYERQ 270
+ RQ
Sbjct: 1650 PQLRRQ 1655
Score = 44.7 bits (104), Expect = 4e-04
Identities = 45/261 (17%), Positives = 122/261 (46%), Gaps = 26/261 (9%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
++++++K+ EE + + EE+ +++ +++Q+Q +++ K K + + + + D
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEE-------- 143
+ ++ R +K +E E + R + + A Q Q EE+
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQE--EKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 144 EEEEK----------HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKF 193
+ EEK PP + E+ + + +Q L ++ KE++ + + + + +
Sbjct: 772 QAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL 831
Query: 194 AALDNEEE----DKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDP 249
L+ EE+ ++ +++ +E++ ++ +E+ + EQ +++ + EEE + +
Sbjct: 832 QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER--KRRRHTL 889
Query: 250 YAHLSKKEKKKLKKQMEYERQ 270
YA + +E+ + ++Q+ E +
Sbjct: 890 YAKPALQEQLRKEQQLLQEEE 910
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/246 (17%), Positives = 116/246 (47%), Gaps = 28/246 (11%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
++ +++ ++D+K ++ E K EEE+ L +++Q++ Q++Q+ +R R +R
Sbjct: 1491 EQQLRRQERDRKFREQELRSQEPERKFL-EEEQQLHRQQRQRKFLQEEQQLRRQERGQQR 1549
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEE 144
++D D E+E + + E +E + +K + +++Q +
Sbjct: 1550 RQDRDRKFREEEQLRQ----------EREEQQLSRQERDRKFR--------LEEQKVRRQ 1591
Query: 145 EEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKE 204
E+E+ ++ ++ + ++Q + +K +E++ + + + + + + + E
Sbjct: 1592 EQERK----FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647
Query: 205 EEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQ 264
EE ++ +Q + + EE+ E EE++ + D + ++E+++L++Q
Sbjct: 1648 EEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF----REEEQQLRRQ 1703
Query: 265 MEYERQ 270
E ER+
Sbjct: 1704 -ERERK 1708
Score = 41.6 bits (96), Expect = 0.003
Identities = 42/219 (19%), Positives = 103/219 (47%), Gaps = 32/219 (14%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQ---QQQQQKKKRDTRK 81
++ +++ + ++K ++ E +Q +E+ K E++Q + ++QQ +++ RK
Sbjct: 1713 EQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Query: 82 GRRKKDVDDDGEEKELM-----ERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALI 136
R ++ + + EE++L + ++ + E++ P+ R GK
Sbjct: 1773 FREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK--------YRWE 1824
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAAL 196
++Q + EE+E++ + E++R +A E+Q A + K +EE+ + + Q +
Sbjct: 1825 EEQLQLEEQEQR-----LRQERDRQYRA---EEQFATQEKSRREEQELWQEEEQKR---- 1872
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGE 235
+ E ++E+ +Q KE+ + + G + EG+
Sbjct: 1873 ----RQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 35.0 bits (79), Expect = 0.29
Identities = 20/76 (26%), Positives = 44/76 (57%), Gaps = 6/76 (7%)
Query: 538 KMYQQKQKELL------KQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQ 591
K QQK+++LL ++ +++EKK +E + + +Q ++ +E R++ + + + +
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 592 DEESQEAPELLKRPKE 607
DE QE +LL+ +E
Sbjct: 1024 DELQQEEEQLLREERE 1039
Score = 34.7 bits (78), Expect = 0.38
Identities = 18/71 (25%), Positives = 47/71 (66%), Gaps = 2/71 (2%)
Query: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
QQ++++LL++ E ++++ +EL+ + ++ + Q +E L R++Q+ RR+ ++ + +E E
Sbjct: 1147 QQEEEQLLRE-EPEKRRRQELERQYREEEELQ-QEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 601 LLKRPKEYTVR 611
L ++ ++ R
Sbjct: 1205 LQRQKRKQRYR 1215
Score = 33.1 bits (74), Expect = 1.1
Identities = 21/72 (29%), Positives = 42/72 (58%), Gaps = 5/72 (6%)
Query: 542 QKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDE--ESQEAP 599
Q+++E L++ E+QE + + + + +Q + ++ L RKQ++ RR+ Q+E E QE
Sbjct: 272 QEEEEQLRKLERQELRRERQE---EEQQQQRLRREQQLRRKQEEERREQQEERREQQERR 328
Query: 600 ELLKRPKEYTVR 611
E + +E +R
Sbjct: 329 EQQEERREQQLR 340
Score = 32.7 bits (73), Expect = 1.4
Identities = 18/71 (25%), Positives = 45/71 (63%), Gaps = 2/71 (2%)
Query: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
QQ++++LL++ E+++++ +EL+ + ++ + Q +E L R++ + RR+ + E E
Sbjct: 1117 QQEEEQLLRE-EREKRRRQELERQYREEEEVQ-QEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 601 LLKRPKEYTVR 611
L++ +E +R
Sbjct: 1175 ELQQEEEQLLR 1185
Score = 31.6 bits (70), Expect = 3.2
Identities = 28/157 (17%), Positives = 69/157 (43%), Gaps = 23/157 (14%)
Query: 134 ALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKF 193
+L+QD+ +EE++ P + E++P + ++ ++E+ + A
Sbjct: 108 SLLQDRRQEEDQRRFEP------------RDRQLEEEPGQRRRQKRQEQERELA------ 149
Query: 194 AALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHL 253
+ EE+ +++E +++++ ++ +E ++ ++ E E EEE +S
Sbjct: 150 ---EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREER--RAEEEQLQSCKGHETEEF 204
Query: 254 SKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAE 290
+E+ + ++ +E R+ K E V Q E
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241
Score = 30.8 bits (68), Expect = 5.5
Identities = 19/78 (24%), Positives = 48/78 (61%), Gaps = 8/78 (10%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRR-----KNQ 591
++ QQ++++LL++ E+++++ +E + + K+ +++ ++ L + +K RR K +
Sbjct: 933 EEQLQQEEEQLLRE-EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 592 DEE--SQEAPELLKRPKE 607
+EE QE +LL+ +E
Sbjct: 992 EEEELQQEEEQLLREERE 1009
Score = 30.0 bits (66), Expect = 9.4
Identities = 16/71 (22%), Positives = 43/71 (60%), Gaps = 2/71 (2%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
+++ Q++++EL Q E++EK+ ++ + ++ +Q +E L R++++ RR+ + E
Sbjct: 903 QQLLQEEEEEL--QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 597 EAPELLKRPKE 607
+ L++ +E
Sbjct: 961 RKDKKLQQKEE 971
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 68.2 bits (165), Expect = 3e-11
Identities = 55/277 (19%), Positives = 126/277 (45%), Gaps = 22/277 (7%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVED-KQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR 83
D + +G++D + LA++ +Q +EKV K++++++++ + K+++ R
Sbjct: 71 DSMEDRGEED--------DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 122
Query: 84 RKKDVDDDGEEKELMERLKKLSVPTSD---EEDEVPAPKPRGGKKTKGGNVFAALIQDQS 140
RK+ ++ + + ER K+ + E D + + + ++ K + +
Sbjct: 123 RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 182
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN-- 198
E EE+ + A+ E + ++ + E+ +K + P+ +F D
Sbjct: 183 RERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR---PPRERFELGDGRK 239
Query: 199 ---EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 255
EE+ +E +++ + + + K AE S E G G EEEEE E + ++ S+
Sbjct: 240 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--EEEEEEEEGSTSE 297
Query: 256 KEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
+ +++ +++ E E + S + ++ VS+ EMS
Sbjct: 298 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 334
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/228 (22%), Positives = 104/228 (45%), Gaps = 23/228 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
DK ++ ++ K+ + D+ E K +E++ ++QQ++Q+++K+R+ R R
Sbjct: 131 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 190
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA-------PKPRGGKKTKGGNVFAALIQ 137
+K+ + E +++ D D+V A P+P + G +
Sbjct: 191 RKEREARREVSAHHRTMRE------DYSDKVKASHWSRSPPRPPRERFELGDG------R 238
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+EE+ EE+ + + K S E A G +EE+ + + + + + +
Sbjct: 239 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 298
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+EEE++EE E+E + G + +EQ +EE E E E+E E++
Sbjct: 299 SEEEEEEE----EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 342
Score = 57.0 bits (136), Expect = 7e-08
Identities = 60/274 (21%), Positives = 116/274 (42%), Gaps = 32/274 (11%)
Query: 17 DGESTSPSDKVVKKGK----KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ 72
D + P ++ +K K KD+K K+ + V++K+ E + +EQ + +++ +
Sbjct: 81 DSLAIKPPQQMSRKEKVHHRKDEKRKEK--KHARVKEKEREHERRKRHREEQDKARREWE 138
Query: 73 QKKKRDTRK--GRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
++K+R+ + RR++D + E K ER + E+ E K+ +
Sbjct: 139 RQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARR 198
Query: 131 VFAALIQDQSEEEEEEEK------HPPKPAKP--EKNRINKAVSEEQQPA------LKGK 176
+A + E+ ++ K PP+P + E K V EE+ L+
Sbjct: 199 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 258
Query: 177 KGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEE 236
E K+ + + EEE++EEE +E+ +E+ EEE E EE
Sbjct: 259 SDSERKTSSAESSSAESGSGSEEEEEEEEE----------EEEEGSTSEESEEEEEEEEE 308
Query: 237 EEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
EEEE G + + + ++++ + E E +
Sbjct: 309 EEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 342
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/194 (20%), Positives = 95/194 (48%), Gaps = 23/194 (11%)
Query: 56 EKVLKEKEQQ-QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERL--------KKLSV 106
+++L+EK+++ +Q+++ + K+ +++ K+D ++GE ++ + ++ S+
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 107 PTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVS 166
EED+ A KP K + + +E+ +E+KH K ++ K
Sbjct: 74 EDRGEEDDSLAIKPPQQMSRK------EKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 167 EEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ 226
EEQ A ++ + +K + A+ ++ E D+ E++ +++E ++ +E+ K+ +
Sbjct: 128 EEQDKA--RREWERQKRREMAREHSR------RERDRLEQLERKRERERKMREQQKEQRE 179
Query: 227 GSEEEGEGEEEEEE 240
E E EE +E
Sbjct: 180 QKERERRAEERRKE 193
Score = 37.7 bits (86), Expect = 0.045
Identities = 36/207 (17%), Positives = 82/207 (39%), Gaps = 57/207 (27%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR------------KKDVDD----------- 90
E E+ ++E++++Q++Q++++++ + RK R ++D D
Sbjct: 165 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 224
Query: 91 -----------DG---------EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
DG EE++L+ L+ +S D E + + + + G
Sbjct: 225 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS----DSERKTSSAESSSAESGSGSE 280
Query: 131 VF----------AALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ ++ EEEEEEE+ + + ++ E + + + +E
Sbjct: 281 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 340
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEI 207
++ P+++F E E+ EEE+
Sbjct: 341 NENHLLVVPESRFDRDSGESEEAEEEV 367
Score = 33.5 bits (75), Expect = 0.85
Identities = 58/286 (20%), Positives = 119/286 (41%), Gaps = 54/286 (18%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
++P + P E +GDG K VK+ K +++ + ++++ +++ E E
Sbjct: 222 RSPPRPPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 275
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
++++++++++ + +G ++ +++ EE+E +EE+E G
Sbjct: 276 GSGSEEEEEEEEEEEE--EGSTSEESEEEEEEEE-------------EEEEET------G 314
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
+ A + ++ E+EE ++ +N + V E + G+ + E+
Sbjct: 315 SNSEEASEQSAEEVSEEEMSEDEEREN--------ENHL-LVVPESRFDRDSGESEEAEE 365
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG--SEEEGEGEEEEEE 240
G+ PQ+ +AL + + + E KQ K A QG S EE + EE
Sbjct: 366 EVGEGTPQS--SALTEGDYVPDSPALSPIE-LKQELPKYLPALQGCRSVEEFQCLNRIEE 422
Query: 241 G-------GESKADDPYAHLSKKEKKKLKKQMEYER-QVASLKAAN 278
G + K D L K+LK + E E + SL+ N
Sbjct: 423 GTYGVVYRAKDKKTDEIVAL-----KRLKMEKEKEGFPITSLREIN 463
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 68.2 bits (165), Expect = 3e-11
Identities = 55/277 (19%), Positives = 126/277 (45%), Gaps = 22/277 (7%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVED-KQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR 83
D + +G++D + LA++ +Q +EKV K++++++++ + K+++ R
Sbjct: 37 DSMEDRGEED--------DSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 88
Query: 84 RKKDVDDDGEEKELMERLKKLSVPTSD---EEDEVPAPKPRGGKKTKGGNVFAALIQDQS 140
RK+ ++ + + ER K+ + E D + + + ++ K + +
Sbjct: 89 RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 148
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN-- 198
E EE+ + A+ E + ++ + E+ +K + P+ +F D
Sbjct: 149 RERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR---PPRERFELGDGRK 205
Query: 199 ---EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 255
EE+ +E +++ + + + K AE S E G G EEEEE E + ++ S+
Sbjct: 206 PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--EEEEEEEEGSTSE 263
Query: 256 KEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
+ +++ +++ E E + S + ++ VS+ EMS
Sbjct: 264 ESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/228 (22%), Positives = 104/228 (45%), Gaps = 23/228 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
DK ++ ++ K+ + D+ E K +E++ ++QQ++Q+++K+R+ R R
Sbjct: 97 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 156
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA-------PKPRGGKKTKGGNVFAALIQ 137
+K+ + E +++ D D+V A P+P + G +
Sbjct: 157 RKEREARREVSAHHRTMRE------DYSDKVKASHWSRSPPRPPRERFELGDG------R 204
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+EE+ EE+ + + K S E A G +EE+ + + + + + +
Sbjct: 205 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 264
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+EEE++EE E+E + G + +EQ +EE E E E+E E++
Sbjct: 265 SEEEEEEE----EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 308
Score = 57.0 bits (136), Expect = 7e-08
Identities = 60/274 (21%), Positives = 116/274 (42%), Gaps = 32/274 (11%)
Query: 17 DGESTSPSDKVVKKGK----KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ 72
D + P ++ +K K KD+K K+ + V++K+ E + +EQ + +++ +
Sbjct: 47 DSLAIKPPQQMSRKEKVHHRKDEKRKEK--KHARVKEKEREHERRKRHREEQDKARREWE 104
Query: 73 QKKKRDTRK--GRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
++K+R+ + RR++D + E K ER + E+ E K+ +
Sbjct: 105 RQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARR 164
Query: 131 VFAALIQDQSEEEEEEEK------HPPKPAKP--EKNRINKAVSEEQQPA------LKGK 176
+A + E+ ++ K PP+P + E K V EE+ L+
Sbjct: 165 EVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDI 224
Query: 177 KGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEE 236
E K+ + + EEE++EEE +E+ +E+ EEE E EE
Sbjct: 225 SDSERKTSSAESSSAESGSGSEEEEEEEEE----------EEEEGSTSEESEEEEEEEEE 274
Query: 237 EEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
EEEE G + + + ++++ + E E +
Sbjct: 275 EEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 308
Score = 37.7 bits (86), Expect = 0.045
Identities = 36/207 (17%), Positives = 82/207 (39%), Gaps = 57/207 (27%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR------------KKDVDD----------- 90
E E+ ++E++++Q++Q++++++ + RK R ++D D
Sbjct: 131 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 190
Query: 91 -----------DG---------EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
DG EE++L+ L+ +S D E + + + + G
Sbjct: 191 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS----DSERKTSSAESSSAESGSGSE 246
Query: 131 VF----------AALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ ++ EEEEEEE+ + + ++ E + + + +E
Sbjct: 247 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 306
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEI 207
++ P+++F E E+ EEE+
Sbjct: 307 NENHLLVVPESRFDRDSGESEEAEEEV 333
Score = 33.5 bits (75), Expect = 0.85
Identities = 58/286 (20%), Positives = 119/286 (41%), Gaps = 54/286 (18%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
++P + P E +GDG K VK+ K +++ + ++++ +++ E E
Sbjct: 188 RSPPRPPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 241
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
++++++++++ + +G ++ +++ EE+E +EE+E G
Sbjct: 242 GSGSEEEEEEEEEEEE--EGSTSEESEEEEEEEE-------------EEEEET------G 280
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
+ A + ++ E+EE ++ +N + V E + G+ + E+
Sbjct: 281 SNSEEASEQSAEEVSEEEMSEDEEREN--------ENHL-LVVPESRFDRDSGESEEAEE 331
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG--SEEEGEGEEEEEE 240
G+ PQ+ +AL + + + E KQ K A QG S EE + EE
Sbjct: 332 EVGEGTPQS--SALTEGDYVPDSPALSPIE-LKQELPKYLPALQGCRSVEEFQCLNRIEE 388
Query: 241 G-------GESKADDPYAHLSKKEKKKLKKQMEYER-QVASLKAAN 278
G + K D L K+LK + E E + SL+ N
Sbjct: 389 GTYGVVYRAKDKKTDEIVAL-----KRLKMEKEKEGFPITSLREIN 429
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 67.8 bits (164), Expect = 4e-11
Identities = 64/277 (23%), Positives = 130/277 (46%), Gaps = 26/277 (9%)
Query: 46 AVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLS 105
A+E+K+ GE++K K+ + ++++++ KK+ ++ + + G+ E + K++
Sbjct: 308 ALEEKE-GEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
Query: 106 VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
+ ++DE K KKTK A + Q + +++E++EKH P+K +V
Sbjct: 367 AQAAAKKDE----KKEDSKKTKKP---AEVEQPKGKKQEKKEKHVEPAKSPKKEH---SV 416
Query: 166 SEEQQPALKGKKGKEE---KSKGKAKPQNKFAA--------LDNEEEDKEEEIIKEKEPP 214
++Q K ++ KEE S KA P K + E+ K I+K+KEP
Sbjct: 417 PSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPI 476
Query: 215 KQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASL 274
K +EK + + E E + +E+ + G+ P L K+++K + Q++ E + A
Sbjct: 477 KGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKP-PQLQGKKEEKPEPQIKKEAKPAIS 535
Query: 275 KAANAAENDFSVSQAEMS---SRQAMLENASDIKLEK 308
+ + D + +S + +L+ + +EK
Sbjct: 536 EKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEK 572
Score = 63.5 bits (153), Expect = 8e-10
Identities = 83/361 (22%), Positives = 156/361 (43%), Gaps = 59/361 (16%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGK-----KDKKIKKTFFEELAVEDKQAGEEEK 57
K KQ+ PE + T + K +KGK K+K KK +E +E K+ E +
Sbjct: 147 KTEKQEKPERKI-----QTKVTHKEKEKGKEKVREKEKPEKKATHKE-KIEKKEKPETKT 200
Query: 58 VLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELM---------ERLKKLSVPT 108
+ KE+++ + ++ ++K K++ + G+++K + KE+ E +K +V
Sbjct: 201 LAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSK 260
Query: 109 SDEEDE-----------------------VPAPKPRGGKKTKGGNVFAALIQDQSEEEEE 145
+++D+ +P P P + ++ AL + + E+++
Sbjct: 261 HEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPT-EQASRPTPASPALEEKEGEKKKA 319
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKK-GKEEKSK-GKAKPQNKFAALDNEEEDK 203
E+K + K EK I K +E ++ K+ GK ++K G K + AA ++++K
Sbjct: 320 EKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAA---KKDEK 376
Query: 204 EEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKK 263
+E+ K K+P + + K KK E+ +E+ E +S + K+ K K ++
Sbjct: 377 KEDSKKTKKPAEVEQPKGKKQEK--------KEKHVEPAKSPKKEHSVPSDKQVKAKTER 428
Query: 264 QMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNAD 323
E V+ KA + + + E R+ S I +K I GKE V A
Sbjct: 429 AKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK--GKEEKVPAS 486
Query: 324 L 324
L
Sbjct: 487 L 487
Score = 56.6 bits (135), Expect = 9e-08
Identities = 65/297 (21%), Positives = 129/297 (43%), Gaps = 32/297 (10%)
Query: 25 DKVVKKGKKDKKIK-----------KTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQ 73
DK K+ K ++KI+ K E +K+A +EK+ K+++ + + ++Q
Sbjct: 146 DKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQ 205
Query: 74 KKKRDTRKG--RRKKDVDDDGEEK------ELMERLKKLSVPTSDEEDEVPAPKPRGGKK 125
KK + K + KK+V +EK ++ E K S P E+ E A K
Sbjct: 206 KKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKD 265
Query: 126 TKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKG 185
+ I + + + P P E+ S PAL+ K+G+++K++
Sbjct: 266 QYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPAS----PALEEKEGEKKKAEK 321
Query: 186 KAKPQNKFAALDNEEEDKEEEI---IKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGG 242
K + K ++ ++ E+E +++KEP K + K + ++ + +E++E+
Sbjct: 322 KVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSK 381
Query: 243 ESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLE 299
++K ++ E+ K KKQ + E+ V K+ + S Q + + +A E
Sbjct: 382 KTKKP------AEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEE 432
Score = 53.9 bits (128), Expect = 6e-07
Identities = 76/291 (26%), Positives = 123/291 (42%), Gaps = 32/291 (10%)
Query: 2 PKAPKQQPPE----PEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEEL-AVEDKQAGEEE 56
PK KQ+ E P E + PSDK VK + K EE+ AV K+A +
Sbjct: 392 PKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAK------EEIGAVSIKKAVPGK 445
Query: 57 KVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVP 116
K +EK + +Q+ +++K T + K+ EEK VP S +E E
Sbjct: 446 K--EEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEK----------VPASLKEKEPE 493
Query: 117 APKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGK 176
K K G V Q Q ++EE+ E K AKP I++ V +Q +K +
Sbjct: 494 TKKDEKMSKA-GKEVKPKPPQLQGKKEEKPEPQIKKEAKPA---ISEKVQIHKQDIVKPE 549
Query: 177 KGKEE-KSKGKAKPQNKFAALDNEEEDKEEEII--KEKEPPKQGKEKAKKAEQGSEEEGE 233
K K + K Q K ++ + K + +E+EPP +K K +G+ E E
Sbjct: 550 KTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTE 609
Query: 234 GEEEEEE--GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAEN 282
+++ E ESK HL +++ K+ ++ + K A +++
Sbjct: 610 SGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKD 660
Score = 42.4 bits (98), Expect = 0.002
Identities = 41/169 (24%), Positives = 79/169 (46%), Gaps = 24/169 (14%)
Query: 106 VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
+ + DEED+ G + T G + ++ + +++ EK KPE+ K
Sbjct: 114 ISSEDEEDD------DGDEDTDKGEIDEPPLRKKEIHKDKTEKQE----KPERKIQTKVT 163
Query: 166 SEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAE 225
+E++ KGKE K + K KP+ K A E+ +K KEK K ++ KKA+
Sbjct: 164 HKEKE------KGKE-KVREKEKPEKK--ATHKEKIEK-----KEKPETKTLAKEQKKAK 209
Query: 226 QGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASL 274
+ E + ++E + G + K A + + +K K + + +++ A++
Sbjct: 210 TAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAV 258
Score = 39.7 bits (91), Expect = 0.012
Identities = 59/307 (19%), Positives = 135/307 (43%), Gaps = 44/307 (14%)
Query: 132 FAALIQD---QSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAK 188
F +L+ D +EE+++ +K I+ +P L+ K+ ++K++ + K
Sbjct: 106 FFSLLSDIISSEDEEDDDGDE-----DTDKGEID-------EPPLRKKEIHKDKTEKQEK 153
Query: 189 PQNKF-AALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKAD 247
P+ K + ++E++K +E ++EKE P++ +K E+ + E + +E++
Sbjct: 154 PERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQK------- 206
Query: 248 DPYAHLSKKEKKKLKKQMEYERQ-VASLKAANAAENDFSVSQAEMSSRQAMLENASDIKL 306
A ++K ++K KK+++ +Q AA E + S+ + + + +
Sbjct: 207 --KAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQK 264
Query: 307 EKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCE 366
++++ + ++FV+ DL G+ + P + S P L E
Sbjct: 265 DQYAFCRYMIDIFVHGDL--KPGQSPAIPPP-----------LPTEQASRPTPASPALEE 311
Query: 367 QEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAA 426
+E E + + ++TK+ + +E+ + + + E D + K E + T A
Sbjct: 312 KE---GEKKKAEKKVTSETKKKE--KEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIA 366
Query: 427 AEAKARR 433
A+A A++
Sbjct: 367 AQAAAKK 373
Score = 30.4 bits (67), Expect = 7.2
Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 7/80 (8%)
Query: 535 TFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKE-------ALTRKQQKCR 587
T K+ ++K+K K K++KK K + + TK+ K K+ A ++ QK
Sbjct: 185 THKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTP 244
Query: 588 RKNQDEESQEAPELLKRPKE 607
K +++E +E + K ++
Sbjct: 245 SKPKEKEDKEKAAVSKHEQK 264
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 65.5 bits (158), Expect = 2e-10
Identities = 58/290 (20%), Positives = 127/290 (43%), Gaps = 41/290 (14%)
Query: 17 DGESTSPSDKVVKKGK----KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ 72
D + P ++ +K K KD+K K+ + V++K+ E + +EQ + +++ +
Sbjct: 81 DSLAIKPPQQMSRKEKVHHRKDEKRKEK--KHARVKEKEREHERRKRHREEQDKARREWE 138
Query: 73 QKKKRDTRKGRRKKDVDDDG-----EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK 127
++K+R+ + +++ +DG + E +ER ++ +++ E K R
Sbjct: 139 RQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKER------ 192
Query: 128 GGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKA 187
E EE+ + A+ E + ++ + E+ +K +
Sbjct: 193 --------------ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR--- 235
Query: 188 KPQNKFAALDN-----EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGG 242
P+ +F D EE+ +E +++ + + + K AE S E G G EEEEE
Sbjct: 236 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE-- 293
Query: 243 ESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
E + ++ S++ +++ +++ E E + S + ++ VS+ EMS
Sbjct: 294 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 343
Score = 56.6 bits (135), Expect = 9e-08
Identities = 47/198 (23%), Positives = 93/198 (46%), Gaps = 23/198 (11%)
Query: 55 EEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDE 114
E K +E++ ++QQ++Q+++K+R+ R R+K+ + E +++ D D+
Sbjct: 170 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE------DYSDK 223
Query: 115 VPA-------PKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE 167
V A P+P + G + +EE+ EE+ + + K S
Sbjct: 224 VKASHWSRSPPRPPRERFELGDG------RKPVKEEKMEERDLLSDLQDISDSERKTSSA 277
Query: 168 EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG 227
E A G +EE+ + + + + + ++EEE++EE E+E + G + +EQ
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE----EEEEEETGSNSEEASEQS 333
Query: 228 SEEEGEGEEEEEEGGESK 245
+EE E E E+E E++
Sbjct: 334 AEEVSEEEMSEDEERENE 351
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/218 (22%), Positives = 95/218 (43%), Gaps = 41/218 (18%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR------------KKDVDDD---------- 91
E E+ ++E++++Q++Q++++++ + RK R ++D D
Sbjct: 174 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 233
Query: 92 ----GEEKELMERLKKLSVPTSDEEDEVPAPKPRGG--KKTKGGNVFAALIQDQSEEEEE 145
E EL + K + +E D + + +KT +A SEEEEE
Sbjct: 234 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 293
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEE 205
EE+ + E+ ++ EE++ +EE+ + + ++ A+ + EE EE
Sbjct: 294 EEEE-----EEEEGSTSEESEEEEE--------EEEEEEEETGSNSEEASEQSAEEVSEE 340
Query: 206 EIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGE 243
E+ +++E + + + GE EE EEE GE
Sbjct: 341 EMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 378
Score = 43.5 bits (101), Expect = 8e-04
Identities = 39/198 (19%), Positives = 94/198 (47%), Gaps = 22/198 (11%)
Query: 56 EKVLKEKEQQ-QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERL--------KKLSV 106
+++L+EK+++ +Q+++ + K+ +++ K+D ++GE ++ + ++ S+
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 107 PTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVS 166
EED+ A KP K + + +E+ +E+KH K ++ K
Sbjct: 74 EDRGEEDDSLAIKPPQQMSRK------EKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 167 EEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE----EDKEEEIIKEKEPPKQGKEKAK 222
EEQ K ++ E + + + ++ N+ D+ E++ +++E ++ +E+ K
Sbjct: 128 EEQD---KARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQK 184
Query: 223 KAEQGSEEEGEGEEEEEE 240
+ + E E EE +E
Sbjct: 185 EQREQKERERRAEERRKE 202
Score = 43.1 bits (100), Expect = 0.001
Identities = 48/234 (20%), Positives = 108/234 (46%), Gaps = 38/234 (16%)
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTR-KGRRKKDVDDDG------EEKELMERLKKLS 105
G+E+ K K + Q+++++K+++ + + +R K+ DD EE EL + +++
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEIT 61
Query: 106 VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKP-AKPEK--NRIN 162
+ S E ++D+ EE++ PP+ ++ EK +R +
Sbjct: 62 IRNSPYRRE-------------------DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQG----- 217
+ E++ +K K+ + E+ K + Q+K A E K E+ +E ++G
Sbjct: 103 EKRKEKKHARVKEKEREHERRKRHREEQDK--ARREWERQKRREMAREHSRRERGNDGVC 160
Query: 218 --KEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYER 269
+++ ++ E+ E E + E+++E E K + A +KE++ ++ + R
Sbjct: 161 LFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 214
Score = 43.1 bits (100), Expect = 0.001
Identities = 43/240 (17%), Positives = 107/240 (44%), Gaps = 18/240 (7%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
++P + P E +GDG K VK+ K +++ + ++++ +++ E E
Sbjct: 231 RSPPRPPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 284
Query: 63 ---EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDE--EDEVPA 117
+++++++++++++ T + +++ +++ EE+E ++ S +++E E+E+
Sbjct: 285 GSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSE 344
Query: 118 PKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK 177
+ R + + +D E EE EE+ P+ + + + PAL +
Sbjct: 345 DEERENENHLLVVPESRFDRDSGESEEAEEE--VGEGTPQSSALTEGDYVPDSPALSPIE 402
Query: 178 GKEEKSK-----GKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEG 232
K+E K + +F L+ EE + + K+ K+ + E+EG
Sbjct: 403 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 462
Score = 32.0 bits (71), Expect = 2.5
Identities = 31/150 (20%), Positives = 65/150 (43%), Gaps = 9/150 (6%)
Query: 135 LIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNK-F 193
++Q++ +E+EEK K K +R +K S E+ G+ + +N +
Sbjct: 16 ILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEE--------GELRDHCMEITIRNSPY 67
Query: 194 AALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHL 253
D+ E+ EE+ +PP+Q K K + E+ E + + E + + H
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHR 127
Query: 254 SKKEKKKLKKQMEYERQVASLKAANAAEND 283
+++K + + + + R++A + ND
Sbjct: 128 EEQDKARREWERQKRREMAREHSRRERGND 157
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 64.7 bits (156), Expect = 3e-10
Identities = 56/295 (18%), Positives = 150/295 (50%), Gaps = 19/295 (6%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ--QKKKRDTRKGRRKK 86
+K +D++ K E + +K+ EEE+ ++E+E++ Q+Q++ ++++++ ++ R +
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 87 DVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ-DQSEEEEE 145
+ E++++ E+ +K+ ++E+++ + G++ K Q DQ E+EE
Sbjct: 496 QKEKLWEQEKMQEQEEKIW----EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPAL--KGKKGKEEKSKGKAKPQNKFAALDNEEEDK 203
+ + + ++ R+ K E+++ + K +EE+ + + K + + E+E+K
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 204 ----EEEIIKEKEPPKQGKEKAKKAEQG--SEEEGEGEEEEEEGGESKADDP----YAHL 253
EE++ +++E + +EK ++ E+ +EE E+EE+ + + + + H
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 254 SKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 308
+E++K+++Q E + ++ + + Q +M ++M E ++ E+
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEE 726
Score = 64.3 bits (155), Expect = 4e-10
Identities = 55/263 (20%), Positives = 121/263 (46%), Gaps = 23/263 (8%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK--KDVDDDGEEKELMER 100
E L ++KQ E+E+ ++++E++ +Q ++ ++K + + + K + V+ EEK++ E+
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 101 LKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR 160
KK T D+E+++ + ++ K EEEE + K K E+N
Sbjct: 436 EKK----TRDQEEKMQEEERIREREKK-----------MREEEETMREQEEKMQKQEENM 480
Query: 161 INKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEK 220
+ E QQ L +K K + + + + K + + D+EE +EK+ +Q K +
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
Query: 221 AKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAA 280
++ + +EE ++E+ K D + KK +++ KK + E ++ +
Sbjct: 541 EQEDQMWEQEEKMRDQEQ------KMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER 594
Query: 281 ENDFSVSQAEMSSRQAMLENASD 303
E + M ++ ++ +
Sbjct: 595 EKKMREEEEMMREQEEKMQEQEE 617
Score = 64.3 bits (155), Expect = 4e-10
Identities = 60/268 (22%), Positives = 125/268 (46%), Gaps = 34/268 (12%)
Query: 7 QQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQ 66
Q+ E W + + +K+ ++ + ++ +K + E E ++ E+E+ + E+E+ +
Sbjct: 634 QEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKME 693
Query: 67 QQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT 126
++ Q+Q+KK D K R EE+ + ER KK+ EE+E+ +
Sbjct: 694 KKTQEQEKKTWDQEKMR---------EEESMREREKKMR-----EEEEMMREQEE----- 734
Query: 127 KGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK 186
+Q+Q E+ +E+E+ + + + K +++ P K K + E K
Sbjct: 735 --------KMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE----K 782
Query: 187 AKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ---GSEEEGEGEEEEEEGGE 243
+ Q K + + D+EE++ ++E + +EK + E+ G EE+ G+EE+ G E
Sbjct: 783 MQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQE 842
Query: 244 SKADDPYAHLSKKEKKKLKKQMEYERQV 271
K + +K + + +K E E ++
Sbjct: 843 EKMWGQEEKMEEKMQGQEEKMREQEEKM 870
Score = 63.5 bits (153), Expect = 8e-10
Identities = 58/276 (21%), Positives = 142/276 (51%), Gaps = 26/276 (9%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
+P+ E W + E K+ K+ +K + ++ E+ E K +EEK+ +
Sbjct: 262 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ---EGKMREQEEKMWR 318
Query: 61 EKE---QQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
+++ +Q+++ ++Q+K+ R+ ++ R +++ + EEK + E+ +K+ ++E+++
Sbjct: 319 QEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK-MWEQEEKM----REQEEKMWR 373
Query: 118 PKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKK 177
+ R ++ K ++DQ E E+++ + K E+ R + + E+ + + KK
Sbjct: 374 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE--KEERMREQEKMWEQVEKMREEKK 431
Query: 178 GKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQ---GSEEEGEG 234
+E++ K + D EE+ +EEE I+E+E + +E+ + ++ +EE
Sbjct: 432 MQEQEKKTR----------DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 481
Query: 235 EEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
E+EE+E + + + L ++EK + +++ +E++
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
Score = 60.5 bits (145), Expect = 6e-09
Identities = 57/277 (20%), Positives = 133/277 (48%), Gaps = 28/277 (10%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ 70
+ E I D E +K + + +K ++ + +E+ E+K +E+K+ ++E+ +++ Q
Sbjct: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ---EEKMRDQEQKMWDQEERMEKKTQ 572
Query: 71 QQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
+Q+KK D + R EE+ + ER KK+ +EE+ + + + ++ +
Sbjct: 573 EQEKKTWDQEEKMR--------EEERMREREKKMR----EEEEMMREQEEKMQEQEEKMQ 620
Query: 131 VFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAK-- 188
+ +Q E+ +E+E+ + + + K +++ P K K + EK + + K
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 189 -------PQNKFAALDNEEEDK--EEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEE 239
Q K E+E K ++E ++E+E ++ ++K ++ E+ E+ E +E+E
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
Query: 240 EGGESKADDPYAHLSK--KEKKKLKKQMEYERQVASL 274
E + + ++ + K ++++K+ +Q Q L
Sbjct: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKL 777
Score = 57.0 bits (136), Expect = 7e-08
Identities = 46/230 (20%), Positives = 117/230 (50%), Gaps = 11/230 (4%)
Query: 34 DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQ----QQQQKKKRDTRKGRRKKDVD 89
D++ K E + +K+ EEE++++E+E++ Q+Q Q+Q++K + + ++++
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Query: 90 DDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKH 149
+E+++ E+ +K+ E+ +P K + + K +Q+Q E+ E+EK
Sbjct: 640 MWEQEEKMWEQEEKMW-----EQQRLPEQKEKLWEHEKMQE--QEKMQEQEEKIWEQEKM 692
Query: 150 PPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK 209
K + EK ++ E++ + +K E+ + + + K + + +++EEE+ +
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
Query: 210 EKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKK 259
++E + +EK + ++ E++ + E E+ + K + + +E+K
Sbjct: 753 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Score = 54.7 bits (130), Expect = 4e-07
Identities = 54/259 (20%), Positives = 131/259 (50%), Gaps = 37/259 (14%)
Query: 9 PPEPEWIGDGESTSPSDKVVKKGKK----DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQ 64
P + E + + E +K+ ++ +K +K KKT +E D++ EE+ ++E+E+
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 65 Q--QQQQ--QQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
+ ++++ ++Q++K ++ + ++++ + +E+++ E+ +K+ E+ +P K
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMW-----EQQRLPEQKE 775
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ + K +Q+Q + E+EEK +++ K +E++ +G+E
Sbjct: 776 KLWEHEK--------MQEQEKIWEQEEK--------MRDQEEKMRGQEEK-----MRGQE 814
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEE 240
EK +G+ + K + + +EE++ ++E +EK ++ QG EE+ +EE+
Sbjct: 815 EKMRGQ---EEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMR 871
Query: 241 GGESKADDPYAHLSKKEKK 259
G E K + + +E+K
Sbjct: 872 GQEEKMREQEEKMRGQEEK 890
Score = 53.9 bits (128), Expect = 6e-07
Identities = 54/256 (21%), Positives = 122/256 (47%), Gaps = 25/256 (9%)
Query: 43 EELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
E+L ++K +EEK+ +++E+ + Q++ ++K+ R+ + ++ D E++E M
Sbjct: 498 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR--- 554
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
D+E ++ + R KKT+ Q++ EEE + K + E+ +
Sbjct: 555 -------DQEQKMWDQEERMEKKTQEQEK-KTWDQEEKMREEERMREREKKMREEEEMMR 606
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE---DKEEEIIKEKEPPKQGKE 219
+ + Q+ K ++ +E+ + + K Q + + +EE ++EE++ +++ P+Q KE
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ-KE 665
Query: 220 KAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANA 279
K + E+ E+E E+EE+ + K EKK +++ + Q + +
Sbjct: 666 KLWEHEKMQEQEKMQEQEEKIWEQEKM----------EKKTQEQEKKTWDQEKMREEESM 715
Query: 280 AENDFSVSQAEMSSRQ 295
E + + + E R+
Sbjct: 716 REREKKMREEEEMMRE 731
Score = 38.9 bits (89), Expect = 0.020
Identities = 48/264 (18%), Positives = 112/264 (42%), Gaps = 18/264 (6%)
Query: 52 AGEEEKVLKE---KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPT 108
AGE ++ L + ++ + ++ K+RD ++ + E K+ L++
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA 237
Query: 109 SDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEE 168
E+ E+ +K + +Q + +EE + + +K R +
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297
Query: 169 QQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGS 228
Q+ L+ ++GK + + K Q K +E ++E+ ++E++ ++ +E+ ++ E+
Sbjct: 298 QEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357
Query: 229 EEEGEGEEEEEEGGESKADDPYAHLSKKEKK--KLKKQMEYERQVASLKAANAAENDFSV 286
E+ E E+EE + ++E++ + +KQM + Q + E D +
Sbjct: 358 WEQEEKMREQEE-----------KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERL 406
Query: 287 SQAE--MSSRQAMLENASDIKLEK 308
+ E M ++ M E ++ EK
Sbjct: 407 REKEERMREQEKMWEQVEKMREEK 430
Score = 35.0 bits (79), Expect = 0.29
Identities = 21/103 (20%), Positives = 55/103 (53%), Gaps = 4/103 (3%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKK----DKKIKKTFFEELAVEDKQAGEEEKVLKE 61
K Q E W + + +K+ + +K ++K++ + E+K G+EEK+ +
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKL 104
+E+ Q+++ ++K + + R+++ G+E+++ E+ +K+
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKM 884
Score = 33.9 bits (76), Expect = 0.65
Identities = 18/77 (23%), Positives = 44/77 (57%), Gaps = 6/77 (7%)
Query: 537 KKMYQQKQK------ELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKN 590
+KM++Q+++ ++ +Q EK ++ K L+ K ++ EK+ +E ++Q+ + +
Sbjct: 293 EKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQE 352
Query: 591 QDEESQEAPELLKRPKE 607
Q+E+ E E ++ +E
Sbjct: 353 QEEKMWEQEEKMREQEE 369
Score = 33.5 bits (75), Expect = 0.85
Identities = 49/267 (18%), Positives = 121/267 (45%), Gaps = 31/267 (11%)
Query: 47 VEDKQAGEEEKV-LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLS 105
++ K A +EK+ L E E+ + Q ++ K RK R K + + L E + +
Sbjct: 223 LKKKNAELQEKLPLAESEKSEIQLNVKELK----RKLERAKFLLPQVQTNTLQEEMWRQE 278
Query: 106 VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
++E ++ + + ++ + L + + + E+EEK ++ R+ +
Sbjct: 279 EELREQEKKIRKQEEKMWRQEE------RLREQEGKMREQEEK-----MWRQEKRLREQE 327
Query: 166 SE--EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE--DKEEEIIKEKEPPKQGKEKA 221
E EQ+ L+ +K E+ + + + K + EE+ ++EE++ +++E + +++
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKM--WEQEEKMREQEEKMWRQEERLWEQEKQM 385
Query: 222 KKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAE 281
++ EQ ++ E E++E K + +E++K+ +Q+E R+ ++
Sbjct: 386 REQEQKMRDQEERMWEQDERLREKEE------RMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 282 NDFSVSQAEMSSRQAMLENASDIKLEK 308
D + +M + + E ++ E+
Sbjct: 440 RD---QEEKMQEEERIREREKKMREEE 463
Score = 33.5 bits (75), Expect = 0.85
Identities = 27/97 (27%), Positives = 51/97 (52%), Gaps = 26/97 (26%)
Query: 537 KKMYQQK----QKELLKQYEK---------QEKKLKELKAGGKSTKQAEKQT-------- 575
+KM++Q+ QKE L ++EK QE+K+ E + K T++ EK+T
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711
Query: 576 KEALTRKQQKCRR-----KNQDEESQEAPELLKRPKE 607
+E++ +++K R + Q+E+ QE E ++ +E
Sbjct: 712 EESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Score = 33.5 bits (75), Expect = 0.85
Identities = 13/50 (26%), Positives = 34/50 (68%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKEL 97
E+K G+EEK+ ++ + Q+++ ++Q++K R + R+++ G+E+++
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 32.0 bits (71), Expect = 2.5
Identities = 18/71 (25%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 541 QQKQKELLKQYEKQEKKLKE----LKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
+QK ++ ++ +Q+++L+E ++ K +Q EK +E ++Q+K + ++Q+E+ Q
Sbjct: 389 EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEK-KTRDQEEKMQ 447
Query: 597 EAPELLKRPKE 607
E + +R K+
Sbjct: 448 EEERIREREKK 458
Score = 31.6 bits (70), Expect = 3.2
Identities = 19/80 (23%), Positives = 46/80 (57%), Gaps = 9/80 (11%)
Query: 537 KKMY-QQKQKELLKQYEKQEKKLKELKAG--------GKSTKQAEKQTKEALTRKQQKCR 587
KKM+ Q+K +E Q +QE+K+++ + K T++ EK+T + + +++ R
Sbjct: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER 590
Query: 588 RKNQDEESQEAPELLKRPKE 607
+ ++++ +E E+++ +E
Sbjct: 591 MREREKKMREEEEMMREQEE 610
Score = 30.8 bits (68), Expect = 5.5
Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 20/103 (19%)
Query: 522 DAQRLHYYRGNYMTFKKMYQQK----QKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKE 577
+ QRL + +KM +Q+ Q+E + + EK EKK +E + K T EK +E
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE---KKTWDQEKMREE 712
Query: 578 ALTRKQQKCRRKN-------------QDEESQEAPELLKRPKE 607
R+++K R+ Q+E+ QE E + +E
Sbjct: 713 ESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 64.7 bits (156), Expect = 3e-10
Identities = 71/306 (23%), Positives = 135/306 (44%), Gaps = 24/306 (7%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
KA + E E + E ++ +G K + ++ E+ +K+ GE+E+ E
Sbjct: 514 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 573
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E + ++ + +++KK + + + + K K VP S E++ +P P+
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 633
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR--INKAVSEEQ------QPALK 174
+ KG + +S EE+ + PK EK + ++K+ EE+ + ++
Sbjct: 634 PVEEKGKSPV-----PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 688
Query: 175 GKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEG 234
K K E KG+ K + + + +E KEE++ K++E PK EK KKAE +EE
Sbjct: 689 EAKSKAEVGKGEQKEEEE---KEVKEAPKEEKVEKKEEKPKDVPEK-KKAESPVKEEAVA 744
Query: 235 EEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSR 294
E + HL +KE K+ K ++ E++ +E + S A+ S +
Sbjct: 745 EV------VTITKSVKVHL-EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 797
Query: 295 QAMLEN 300
+ + N
Sbjct: 798 EDIAVN 803
Score = 58.9 bits (141), Expect = 2e-08
Identities = 72/309 (23%), Positives = 130/309 (42%), Gaps = 17/309 (5%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ-QKKKR 77
E + S K KK ++K ++ EE V K++ + + KE++ ++++++ Q+++
Sbjct: 478 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 537
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG------GKKTKGGNV 131
+ +G + ++ G EKE ++ + E E + +K++
Sbjct: 538 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 597
Query: 132 FAALIQDQSEEEEEEEKHP-PKPAKPEKNR--INKAVSEEQQPALKGKKGKEEKSKGKAK 188
L+ D E+ E+ K P PK EK + + K+ EE+ + K EEK K
Sbjct: 598 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 656
Query: 189 PQNKFAALDNEEEDKEEEIIKEKEP-PKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKAD 247
P++ K K K P PK E+AK E G+GE++EEE E K
Sbjct: 657 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAK----SKAEVGKGEQKEEEEKEVKEA 712
Query: 248 DPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLE 307
+ KKE+K K E ++ + +K AE ++ + E ++ E
Sbjct: 713 PKEEKVEKKEEKP-KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 771
Query: 308 KFSISAHGK 316
K A G+
Sbjct: 772 KEKEKAGGE 780
Score = 57.0 bits (136), Expect = 7e-08
Identities = 77/338 (22%), Positives = 150/338 (44%), Gaps = 33/338 (9%)
Query: 104 LSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINK 163
+++ + ++ +V APK + K +I++ E+E+ E A E+ +
Sbjct: 430 ITISSKIQKPKVEAPKLKVQHK-----FVEEIIEETKVEDEKSEMEEALTAITEELAV-- 482
Query: 164 AVSEEQQPALKGK----KGKEEKSKGKAKPQNKFAALDNEEE-DKEEEIIKEKEPPKQGK 218
++ EE++ A + K + +EE+ K P A EEE +KEEE +E+E +
Sbjct: 483 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 219 EKAKKAEQ-GSEEEG--EGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLK 275
K+ +AE+ GSE+EG E EE E+E GE++A+ KE+KK++++ E +VA+ +
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE---EVATKE 599
Query: 276 AANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV 335
A +A+ ++ +E + K + GK + +
Sbjct: 600 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV----------- 648
Query: 336 GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEER 395
KGK+ + K P + + + + ++P +A +A+ + + EEE
Sbjct: 649 --EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 706
Query: 396 R--LQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKA 431
+ + E+ + E+ + V E+ +A EA A
Sbjct: 707 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 744
Score = 54.7 bits (130), Expect = 4e-07
Identities = 68/266 (25%), Positives = 113/266 (42%), Gaps = 51/266 (19%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
+GE+ + ++ + K++KK+++ EE+A +++ + + EK + + ++K
Sbjct: 568 EGETEAEAEGEEAEAKEEKKVEEKS-EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKG 626
Query: 77 RDT-------RKGRR---KKDVDDDGEE---KELMERLKKLSVPTSDEEDEVPAPKPRGG 123
+ KG+ K V++ G+ K +E K V S E++ +P P+
Sbjct: 627 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP 686
Query: 124 KKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKS 183
+ +Q EEEE+E K PK K EK EE+ + KK E
Sbjct: 687 VEEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKK-------EEKPKDVPEKKKAESPV 738
Query: 184 KGKAKPQ----NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKA-EQGSEEEG------ 232
K +A + K + E+E KEE +P +Q KEK K E GSEEEG
Sbjct: 739 KEEAVAEVVTITKSVKVHLEKETKEEG-----KPLQQEKEKEKAGGEGGSEEEGSDKGAK 793
Query: 233 -------------EGEEEEEEGGESK 245
EG+EE E+ + K
Sbjct: 794 GSRKEDIAVNGEVEGKEEVEQETKEK 819
Score = 51.2 bits (121), Expect = 4e-06
Identities = 64/292 (21%), Positives = 126/292 (43%), Gaps = 50/292 (17%)
Query: 36 KIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK 95
K++ F EE+ +E+ + E+EK E+ ++ K + ++ +K+ + + EE+
Sbjct: 447 KVQHKFVEEI-IEETKV-EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE 504
Query: 96 ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAK 155
E ++ S + P K G+K +++ +EEEEEE K +
Sbjct: 505 E-------VAAKKSPVKATAPEVKEEEGEKE----------EEEGQEEEEEEDEGAKSDQ 547
Query: 156 PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEP 213
E+ K S E++ +G++E+ + +A+ + + A E+ E+K EE+ ++E
Sbjct: 548 AEEGGSEKEGSSEKE------EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601
Query: 214 PKQGK----EKAKKAEQGSEEEGEG-----EEEEEEGGES-----------KADDPYAHL 253
K EKAK S E +G + EE G+S K+ P + +
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 661
Query: 254 SKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIK 305
+K K + K E+ + + + E + S+AE+ + E ++K
Sbjct: 662 EEKGKSPVSKSPVEEKAKSPVPKSPVEE---AKSKAEVGKGEQKEEEEKEVK 710
Score = 50.8 bits (120), Expect = 5e-06
Identities = 62/260 (23%), Positives = 108/260 (41%), Gaps = 24/260 (9%)
Query: 1 MPKAP---KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVE-----DKQA 52
+PK+P K + P P+ + + SP K + K + K+ EE + +Q
Sbjct: 643 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 702
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
EEEK +KE ++++ +++++K K K + + V ++ E++ K + V E
Sbjct: 703 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA-VAEVVTITKSVKVHLEKET 761
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV--SEEQQ 170
E P + +K K G + EEE K ++ E +N V EE +
Sbjct: 762 KEEGKPLQQEKEKEKAGG--------EGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 813
Query: 171 PALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEPPK---QGKEKAKKAE 225
K K E+ KG + D ++ + EE+++ K K +G + A K
Sbjct: 814 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYI 873
Query: 226 QGSEEEGEGEEEEEEGGESK 245
S + EE EE E K
Sbjct: 874 TKSVTVTQKVEEHEETFEEK 893
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/233 (21%), Positives = 98/233 (42%), Gaps = 30/233 (12%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGE----EE 56
+PK+P ++ +G GE +K VK+ K++K++K + V +K+ E EE
Sbjct: 682 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 741
Query: 57 KVL--------------KEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
V KE +++ + QQ+++K++ +G +++ D G + E +
Sbjct: 742 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 801
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
EE E + G++ + G V L ++E++ +K EK +
Sbjct: 802 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDK------SEEKVVVT 855
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPK 215
K V + +G + +K K ++ EE EE+++ K+ K
Sbjct: 856 KTVEKIT------SEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 902
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 64.7 bits (156), Expect = 3e-10
Identities = 71/306 (23%), Positives = 135/306 (44%), Gaps = 24/306 (7%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
KA + E E + E ++ +G K + ++ E+ +K+ GE+E+ E
Sbjct: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E + ++ + +++KK + + + + K K VP S E++ +P P+
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKS 257
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR--INKAVSEEQ------QPALK 174
+ KG + +S EE+ + PK EK + ++K+ EE+ + ++
Sbjct: 258 PVEEKGKSPV-----PKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVE 312
Query: 175 GKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEG 234
K K E KG+ K + + + +E KEE++ K++E PK EK KKAE +EE
Sbjct: 313 EAKSKAEVGKGEQKEEEE---KEVKEAPKEEKVEKKEEKPKDVPEK-KKAESPVKEEAVA 368
Query: 235 EEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSR 294
E + HL +KE K+ K ++ E++ +E + S A+ S +
Sbjct: 369 EV------VTITKSVKVHL-EKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRK 421
Query: 295 QAMLEN 300
+ + N
Sbjct: 422 EDIAVN 427
Score = 58.9 bits (141), Expect = 2e-08
Identities = 72/309 (23%), Positives = 130/309 (42%), Gaps = 17/309 (5%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ-QKKKR 77
E + S K KK ++K ++ EE V K++ + + KE++ ++++++ Q+++
Sbjct: 102 EELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEE 161
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG------GKKTKGGNV 131
+ +G + ++ G EKE ++ + E E + +K++
Sbjct: 162 EEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVAT 221
Query: 132 FAALIQDQSEEEEEEEKHP-PKPAKPEKNR--INKAVSEEQQPALKGKKGKEEKSKGKAK 188
L+ D E+ E+ K P PK EK + + K+ EE+ + K EEK K
Sbjct: 222 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPV- 280
Query: 189 PQNKFAALDNEEEDKEEEIIKEKEP-PKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKAD 247
P++ K K K P PK E+AK E G+GE++EEE E K
Sbjct: 281 PKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAK----SKAEVGKGEQKEEEEKEVKEA 336
Query: 248 DPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLE 307
+ KKE+K K E ++ + +K AE ++ + E ++ E
Sbjct: 337 PKEEKVEKKEEKP-KDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQE 395
Query: 308 KFSISAHGK 316
K A G+
Sbjct: 396 KEKEKAGGE 404
Score = 57.0 bits (136), Expect = 7e-08
Identities = 77/338 (22%), Positives = 150/338 (44%), Gaps = 33/338 (9%)
Query: 104 LSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINK 163
+++ + ++ +V APK + K +I++ E+E+ E A E+ +
Sbjct: 54 ITISSKIQKPKVEAPKLKVQHK-----FVEEIIEETKVEDEKSEMEEALTAITEELAV-- 106
Query: 164 AVSEEQQPALKGK----KGKEEKSKGKAKPQNKFAALDNEEE-DKEEEIIKEKEPPKQGK 218
++ EE++ A + K + +EE+ K P A EEE +KEEE +E+E +
Sbjct: 107 SMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEG 166
Query: 219 EKAKKAEQ-GSEEEG--EGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLK 275
K+ +AE+ GSE+EG E EE E+E GE++A+ KE+KK++++ E +VA+ +
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE---EVATKE 223
Query: 276 AANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV 335
A +A+ ++ +E + K + GK + +
Sbjct: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV----------- 272
Query: 336 GPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEER 395
KGK+ + K P + + + + ++P +A +A+ + + EEE
Sbjct: 273 --EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEE 330
Query: 396 R--LQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKA 431
+ + E+ + E+ + V E+ +A EA A
Sbjct: 331 KEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVA 368
Score = 54.7 bits (130), Expect = 4e-07
Identities = 68/266 (25%), Positives = 113/266 (42%), Gaps = 51/266 (19%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
+GE+ + ++ + K++KK+++ EE+A +++ + + EK + + ++K
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEKS-EEVATKEELVADAKVEKPEKAKSPVPKSPVEEKG 250
Query: 77 RDT-------RKGRR---KKDVDDDGEE---KELMERLKKLSVPTSDEEDEVPAPKPRGG 123
+ KG+ K V++ G+ K +E K V S E++ +P P+
Sbjct: 251 KSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSP 310
Query: 124 KKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKS 183
+ +Q EEEE+E K PK K EK EE+ + KK E
Sbjct: 311 VEEAKSKAEVGK-GEQKEEEEKEVKEAPKEEKVEKK-------EEKPKDVPEKKKAESPV 362
Query: 184 KGKAKPQ----NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKA-EQGSEEEG------ 232
K +A + K + E+E KEE +P +Q KEK K E GSEEEG
Sbjct: 363 KEEAVAEVVTITKSVKVHLEKETKEEG-----KPLQQEKEKEKAGGEGGSEEEGSDKGAK 417
Query: 233 -------------EGEEEEEEGGESK 245
EG+EE E+ + K
Sbjct: 418 GSRKEDIAVNGEVEGKEEVEQETKEK 443
Score = 51.2 bits (121), Expect = 4e-06
Identities = 64/292 (21%), Positives = 126/292 (43%), Gaps = 50/292 (17%)
Query: 36 KIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK 95
K++ F EE+ +E+ + E+EK E+ ++ K + ++ +K+ + + EE+
Sbjct: 71 KVQHKFVEEI-IEETKV-EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEE 128
Query: 96 ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAK 155
E ++ S + P K G+K +++ +EEEEEE K +
Sbjct: 129 E-------VAAKKSPVKATAPEVKEEEGEKE----------EEEGQEEEEEEDEGAKSDQ 171
Query: 156 PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEP 213
E+ K S E++ +G++E+ + +A+ + + A E+ E+K EE+ ++E
Sbjct: 172 AEEGGSEKEGSSEKE------EGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
Query: 214 PKQGK----EKAKKAEQGSEEEGEG-----EEEEEEGGES-----------KADDPYAHL 253
K EKAK S E +G + EE G+S K+ P + +
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPV 285
Query: 254 SKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIK 305
+K K + K E+ + + + E + S+AE+ + E ++K
Sbjct: 286 EEKGKSPVSKSPVEEKAKSPVPKSPVEE---AKSKAEVGKGEQKEEEEKEVK 334
Score = 50.8 bits (120), Expect = 5e-06
Identities = 62/260 (23%), Positives = 108/260 (41%), Gaps = 24/260 (9%)
Query: 1 MPKAP---KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVE-----DKQA 52
+PK+P K + P P+ + + SP K + K + K+ EE + +Q
Sbjct: 267 VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQK 326
Query: 53 GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
EEEK +KE ++++ +++++K K K + + V ++ E++ K + V E
Sbjct: 327 EEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEA-VAEVVTITKSVKVHLEKET 385
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV--SEEQQ 170
E P + +K K G + EEE K ++ E +N V EE +
Sbjct: 386 KEEGKPLQQEKEKEKAGG--------EGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVE 437
Query: 171 PALKGKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIKEKEPPK---QGKEKAKKAE 225
K K E+ KG + D ++ + EE+++ K K +G + A K
Sbjct: 438 QETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDGATKYI 497
Query: 226 QGSEEEGEGEEEEEEGGESK 245
S + EE EE E K
Sbjct: 498 TKSVTVTQKVEEHEETFEEK 517
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/233 (21%), Positives = 98/233 (42%), Gaps = 30/233 (12%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGE----EE 56
+PK+P ++ +G GE +K VK+ K++K++K + V +K+ E EE
Sbjct: 306 VPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEE 365
Query: 57 KVL--------------KEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK 102
V KE +++ + QQ+++K++ +G +++ D G + E +
Sbjct: 366 AVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIA 425
Query: 103 KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRIN 162
EE E + G++ + G V L ++E++ +K EK +
Sbjct: 426 VNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDK------SEEKVVVT 479
Query: 163 KAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPK 215
K V + +G + +K K ++ EE EE+++ K+ K
Sbjct: 480 KTVEKIT------SEGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 64.3 bits (155), Expect = 4e-10
Identities = 60/260 (23%), Positives = 117/260 (45%), Gaps = 33/260 (12%)
Query: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKK 125
+++++ +QK ++D R+ +RK EKE + + S+PT +ED PA +
Sbjct: 728 EEERRHRQKLEKDKRRKKRK--------EKEKKGKRRHSSLPTESDEDIAPAQQV----- 774
Query: 126 TKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE-EQQPALKGKKGKEEKS- 183
++ + + + +E++K P P + ++K +++ E+ P K + + KS
Sbjct: 775 ----DIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSP 830
Query: 184 --------KGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGE 235
K KP+ K +E DKE++ KEKE K K K KK + EE +G+
Sbjct: 831 EKDVPMVEKKSKKPKKKEKKHKEKERDKEKK--KEKEKKKSPKPKKKKHRKEKEERTKGK 888
Query: 236 EEEEE---GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
++ ++ G E A +P + E+++L + Y + + S+ +
Sbjct: 889 KKSKKQPPGSEEAAGEPVQN-GAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQV 947
Query: 293 SRQAMLENASDIKLEKFSIS 312
+ +LEN S L+ +S
Sbjct: 948 TVAIVLENRSSSILKGMELS 967
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/116 (26%), Positives = 60/116 (51%), Gaps = 8/116 (6%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
P A ++ P + S SP V KK KK KK +E ++K+ +E+K KE
Sbjct: 809 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK---KEKKHKEKERDKEKKKEKE 865
Query: 62 KEQQQQQQQQQQKKKRDTR-KGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVP 116
K++ + ++++ +K+++ R KG++K G E+ E ++ + EE+++P
Sbjct: 866 KKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQN----GAPEEEQLP 917
Score = 33.1 bits (74), Expect = 1.1
Identities = 35/144 (24%), Positives = 65/144 (45%), Gaps = 20/144 (13%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVE-DKQAGEEEKVLKEKEQQQQQQQQ------ 71
E+ PSD+ D K + L ++ DK + EK+ +K + + +
Sbjct: 783 ENALPSDE-------DDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVP 835
Query: 72 --QQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK-- 127
++K K+ +K ++ K+ + D E+K+ E+ KK P + + + +G KK+K
Sbjct: 836 MVEKKSKKPKKKEKKHKEKERDKEKKKEKEK-KKSPKPKKKKHRKEKEERTKGKKKSKKQ 894
Query: 128 -GGNVFAALIQDQSEEEEEEEKHP 150
G+ AA Q+ EEE+ P
Sbjct: 895 PPGSEEAAGEPVQNGAPEEEQLPP 918
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 64.3 bits (155), Expect = 4e-10
Identities = 55/276 (19%), Positives = 124/276 (44%), Gaps = 21/276 (7%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVED-KQAGEEEKVLKEKEQQQQQQQQQQ--KKKRDTRK 81
D + +G++D + LA++ +Q +EKV K+++++++ + K++ R+
Sbjct: 71 DSMEDRGEED--------DSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERR 122
Query: 82 GRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSE 141
R +++ D E E +R + + E D + + + ++ K + +
Sbjct: 123 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 182
Query: 142 EEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDN--- 198
E EE+ + A+ E + ++ + E+ +K + P+ +F D
Sbjct: 183 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR---PPRERFELGDGRKP 239
Query: 199 --EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKK 256
EE+ +E +++ + + + K AE S E G G EEEEE E + ++ S++
Sbjct: 240 VKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--EEEEEEEEGSTSEE 297
Query: 257 EKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
+++ +++ E E + S + ++ VS+ EMS
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 333
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/228 (22%), Positives = 104/228 (45%), Gaps = 23/228 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
DK ++ ++ K+ + D+ E K +E++ ++QQ++Q+++K+R+ R R
Sbjct: 130 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 189
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA-------PKPRGGKKTKGGNVFAALIQ 137
+K+ + E +++ D D+V A P+P + G +
Sbjct: 190 RKEREARREVSAHHRTMRE------DYSDKVKASHWSRSPPRPPRERFELGDG------R 237
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+EE+ EE+ + + K S E A G +EE+ + + + + + +
Sbjct: 238 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 297
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+EEE++EE E+E + G + +EQ +EE E E E+E E++
Sbjct: 298 SEEEEEEE----EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 341
Score = 55.8 bits (133), Expect = 2e-07
Identities = 56/272 (20%), Positives = 117/272 (43%), Gaps = 29/272 (10%)
Query: 17 DGESTSPSDKVVKKGK----KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQ 72
D + P ++ +K K KD+K +K ++ V++++ ++ +E+++ +++ ++Q
Sbjct: 81 DSLAIKPPQQMSRKEKVHHRKDEK-RKEKWKHARVKEREHERRKRHREEQDKARREWERQ 139
Query: 73 QKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVF 132
++++ RR++D + E K ER + E+ E K+ +
Sbjct: 140 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 199
Query: 133 AALIQDQSEEEEEEEK------HPPKPAKP--EKNRINKAVSEEQQPA------LKGKKG 178
+A + E+ ++ K PP+P + E K V EE+ L+
Sbjct: 200 SAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 259
Query: 179 KEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEE 238
E K+ + + EEE++EEE +E+ +E+ EEE E EEEE
Sbjct: 260 SERKTSSAESSSAESGSGSEEEEEEEEE----------EEEEGSTSEESEEEEEEEEEEE 309
Query: 239 EEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
EE G + + + ++++ + E E +
Sbjct: 310 EETGSNSEEASEQSAEEVSEEEMSEDEERENE 341
Score = 43.1 bits (100), Expect = 0.001
Identities = 38/191 (19%), Positives = 89/191 (46%), Gaps = 18/191 (9%)
Query: 56 EKVLKEKEQQ-QQQQQQQQK--KKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
+++L+EK+++ +Q+++ + K K D R +R D EE EL + ++++ S
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR-----DSLEEGELRDHCMEITIRNSPYR 68
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172
E + +G + I+ + +E+ H K K ++ + V E +
Sbjct: 69 RE-------DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHER 121
Query: 173 LKGKKGKEEKSKGKAKPQNKFAAL---DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSE 229
K + +++K++ + + Q + E D+ E++ +++E ++ +E+ K+ + E
Sbjct: 122 RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 181
Query: 230 EEGEGEEEEEE 240
E EE +E
Sbjct: 182 RERRAEERRKE 192
Score = 37.7 bits (86), Expect = 0.045
Identities = 36/207 (17%), Positives = 82/207 (39%), Gaps = 57/207 (27%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR------------KKDVDD----------- 90
E E+ ++E++++Q++Q++++++ + RK R ++D D
Sbjct: 164 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 223
Query: 91 -----------DG---------EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
DG EE++L+ L+ +S D E + + + + G
Sbjct: 224 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS----DSERKTSSAESSSAESGSGSE 279
Query: 131 VF----------AALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ ++ EEEEEEE+ + + ++ E + + + +E
Sbjct: 280 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 339
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEI 207
++ P+++F E E+ EEE+
Sbjct: 340 NENHLLVVPESRFDRDSGESEEAEEEV 366
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 64.3 bits (155), Expect = 4e-10
Identities = 53/237 (22%), Positives = 123/237 (51%), Gaps = 15/237 (6%)
Query: 48 EDKQAGEEEKVLKEKEQQQQQQQ---QQQKKKRDTRKGRRKKDVDDDGEEK-----ELME 99
++++ E+++ L+EKE++ ++Q+ QQ++K R+ +K + ++ D EEK + E
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRE 564
Query: 100 RLKKLSVPTS---DEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKP 156
R KK+ ++E+++ + + ++ + +Q+Q E+ E+E+ + +
Sbjct: 565 REKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 157 EKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQ 216
+K + + + EQ+ ++ ++ K + + K + Q + E+ +EE ++E+E Q
Sbjct: 625 DKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ 684
Query: 217 GKEKAKKAEQ----GSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYER 269
G+E+ + ++ G EE+ G+EE+ G E K K+E+ + +K+ ER
Sbjct: 685 GQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQER 741
Score = 63.2 bits (152), Expect = 1e-09
Identities = 54/254 (21%), Positives = 134/254 (52%), Gaps = 13/254 (5%)
Query: 11 EPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ 70
+ E I D E +K + + +K ++ + +E+ E+K +E+K+ ++E+ +Q +
Sbjct: 458 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ---EEKMRDQEQKMWDQEERMWEQDE 514
Query: 71 QQQKKKRDTRKGRRKKDVDDD-GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGG 129
+ ++K+ R+ ++ ++ EEK+ E+ KK T D+E+++ + R ++ K
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREEKKTQEQEKK----TWDQEEKM-REEERMREREKKM 569
Query: 130 NVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKP 189
++++Q E+ +E+E+ + + + K +E++ + +K E++ + K +
Sbjct: 570 REEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQE 629
Query: 190 QNKFAALDNEE-EDKEEEIIKEKEPPKQGKEKAKKAE---QGSEEEGEGEEEEEEGGESK 245
Q + E+ +++EE++ +++E ++ +EK ++ E QG EE+ +EE+ +G E K
Sbjct: 630 QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689
Query: 246 ADDPYAHLSKKEKK 259
+ + +E+K
Sbjct: 690 MREQEEKMRGQEEK 703
Score = 58.9 bits (141), Expect = 2e-08
Identities = 61/267 (22%), Positives = 120/267 (44%), Gaps = 22/267 (8%)
Query: 48 EDKQAGEEEKVLKEKE---QQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKL 104
E+K +EEK+ +++E +Q++Q ++Q++K RD + R + D+ EKE ER+++
Sbjct: 323 EEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE--RMWEQDERLREKE--ERMREQ 378
Query: 105 SVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKA 164
EE + R +K EEEE + K K E+N +
Sbjct: 379 EKMWEQEEKMQEEERIREREKK------------MREEEETMREQEEKMQKQEENMWEQE 426
Query: 165 VSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKA 224
E QQ L +K K + + + + K + + D+EE +EK+ +Q K + ++
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Query: 225 EQGSEEEGEGEEEEEE-GGESKADDPYAHLSKKEK--KKLKKQMEYERQVASLKAANAAE 281
+ +EE ++E++ E + + L +KE+ ++ KK + E ++ K E
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE 546
Query: 282 NDFSVSQAEMSSRQAMLENASDIKLEK 308
+ +M + M E ++ E+
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEE 573
Score = 58.2 bits (139), Expect = 3e-08
Identities = 71/335 (21%), Positives = 152/335 (45%), Gaps = 24/335 (7%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK-- 60
K + + E W + E +++ ++ KK ++ ++T E+ E+K +EE + +
Sbjct: 371 KEERMREQEKMWEQE-EKMQEEERIREREKKMREEEETMREQ---EEKMQKQEENMWEQE 426
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK-----ELMERLKKL--SVPTSDEED 113
EKE QQQ+ +Q++K + K + +++ + EEK E+ + KK+ ++ED
Sbjct: 427 EKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 486
Query: 114 EV--PAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPA--KPEKNRINKAVSEEQ 169
++ K R ++ QD+ E+EE K + EK R K E++
Sbjct: 487 QMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQE 546
Query: 170 QPAL--KGKKGKEEKSKGKAKPQNKFAALDNEEEDK----EEEIIKEKEPPKQGKEKAKK 223
+ + K +EE+ + + K + + E+E+K EE++ +++E + +EK ++
Sbjct: 547 KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQE 606
Query: 224 AEQGS-EEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAEN 282
E+ E+E + E+EEE + ++ +K +++ +K E E ++ + +
Sbjct: 607 QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Query: 283 DFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKE 317
+ Q E Q + K+ + G+E
Sbjct: 667 EKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701
Score = 57.4 bits (137), Expect = 5e-08
Identities = 46/250 (18%), Positives = 129/250 (51%), Gaps = 9/250 (3%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQ---QQQKKKRDTRK 81
D+ + ++D+++++ E + + K +EEK+ +EK+ Q+Q+++ Q++K + + R
Sbjct: 504 DQEERMWEQDERLREKE-ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM 562
Query: 82 GRRKKDVDDDGEE-KELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQS 140
R+K + ++ E +E E++++ ++E+++ + + ++ + + +Q
Sbjct: 563 REREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE 622
Query: 141 EEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEE 200
EE++ +E+ + EK + + EQ+ ++ ++ K + + K + Q + E+
Sbjct: 623 EEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEK 682
Query: 201 EDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKK 260
+EE ++E+E +G+E+ + +EE +EE+ G+ + + + +++K
Sbjct: 683 MQGQEEKMREQEEKMRGQEE----KMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKM 738
Query: 261 LKKQMEYERQ 270
++ E+E +
Sbjct: 739 QERLPEHEER 748
Score = 55.1 bits (131), Expect = 3e-07
Identities = 62/302 (20%), Positives = 142/302 (47%), Gaps = 24/302 (7%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQA--GEEEKVLKEKEQQQQQQQ--QQQKKKRDTR 80
+K+ ++ K ++ +K + +E + D++ G+E+K+ ++++ ++Q+ Q +Q++K RD
Sbjct: 440 EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQE 499
Query: 81 K---GRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
+ + ++ + D +E ER+++ EE K R KKT+ +
Sbjct: 500 QKMWDQEERMWEQDERLREKEERMREQKKMWQQEE------KMREEKKTQEQEKKTWDQE 553
Query: 138 DQSEEEEE-EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGK----EEKSKGKAKP--Q 190
++ EEE E+ + E R + +EQ+ ++ ++ K EEK + + + +
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWE 613
Query: 191 NKFAALDNEEEDK----EEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKA 246
+ + EEEDK EE + +++E ++ +EK + E+ E+ E E+EE + +
Sbjct: 614 QEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQE 673
Query: 247 DDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKL 306
+ K + ++ K + + E+ + E + +M ++ M E I+
Sbjct: 674 EKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRD 733
Query: 307 EK 308
+K
Sbjct: 734 QK 735
Score = 54.3 bits (129), Expect = 5e-07
Identities = 58/283 (20%), Positives = 141/283 (49%), Gaps = 27/283 (9%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
+P+ E W + E K+ K+ +K + ++ E+ E K +EEK+ +
Sbjct: 224 LPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQ---EGKMREQEEKMRR 280
Query: 61 EKE---QQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
+++ +Q+++ ++Q+K+ R+ +K R +++ + EEK + E+ +K+ ++E+++
Sbjct: 281 QEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK-MWEQEEKM----REQEEKMWR 335
Query: 118 PKPRGGKKTKGGNVFAALIQDQSEE--EEEEEKHPPKPAKPEKNRI---NKAVSEEQQPA 172
+ R ++ K ++DQ E E++E + E+ ++ + + EE++
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR 395
Query: 173 LKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGK--EKAKKAEQGS-- 228
+ KK +EE+ + + + +N E +E+E +++ P ++ K E+ K EQ
Sbjct: 396 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKI 455
Query: 229 -EEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
E+E + ++EE G+ K + ++EK + ++ +E++
Sbjct: 456 WEQEEKIRDQEEMWGQEK------KMWRQEKMREQEDQMWEQE 492
Score = 54.3 bits (129), Expect = 5e-07
Identities = 54/261 (20%), Positives = 128/261 (49%), Gaps = 34/261 (13%)
Query: 40 TFFEELAVEDKQAGEEEKVLKEKEQ----QQQQQQQQQKKKRDTRKGRRKKDVDDDGEEK 95
T EE+ ++++ E+EK ++++E+ Q+++ ++Q+ K R+ + R+++ +EK
Sbjct: 231 TLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEK 290
Query: 96 ELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAK 155
EL E+ K+L R KK +++Q E+ +E+E+ + +
Sbjct: 291 ELREQEKEL----------------REQKK----------LREQEEQMQEQEEKMWEQEE 324
Query: 156 PEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPK 215
+ + K +E++ + K+ +E++ K + + + + +E ++EE ++E+E
Sbjct: 325 KMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE--QDERLREKEERMREQEKMW 382
Query: 216 QGKEKAKKAEQGSEEEGEGEEEEE--EGGESKADDPYAHLSKKEKKKLKKQMEYERQVAS 273
+ +EK ++ E+ E E + EEEE E K ++ ++E+K+ ++Q E++
Sbjct: 383 EQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Query: 274 LKAANAAENDFSVSQAEMSSR 294
+ E + + + E R
Sbjct: 443 WEQEKMQEQEEKIWEQEEKIR 463
Score = 53.1 bits (126), Expect = 1e-06
Identities = 47/236 (19%), Positives = 118/236 (50%), Gaps = 16/236 (6%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAV-EDKQAGEEEKVLKEKEQ----QQQQQQQQQKKKRDT 79
+K+ ++ K ++ KKT+ +E + E+++ E EK ++E+E+ Q+++ Q+Q++K R+
Sbjct: 534 EKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQ 593
Query: 80 RKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQ 139
+ +++ +E+++ E+ +K+ +EED++ + ++ + + Q
Sbjct: 594 EEKMWEQEEKMQEQEEKMWEQEEKMW--EQEEEDKMQEQEEMMWEQEE---------KMQ 642
Query: 140 SEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNE 199
+EE+ E+ + EK R + + Q+ ++ ++ K + + K + Q + E
Sbjct: 643 EQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEE 702
Query: 200 EEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSK 255
+ +EE + +E G+E+ ++ E+ ++ E +E E + +P SK
Sbjct: 703 KMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSK 758
Score = 50.1 bits (118), Expect = 9e-06
Identities = 55/270 (20%), Positives = 126/270 (46%), Gaps = 37/270 (13%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
M + K Q E + E +++ ++ KK ++ ++ E+ E+K +EEK+ +
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQ---EEKMQEQEEKMRE 592
Query: 61 EKE---QQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELM-----ERLKKLSVPTSDEE 112
++E +Q+++ Q+Q++K + + +++ +D +E+E M E++++ ++E
Sbjct: 593 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQE 652
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172
+++ + + ++ + + Q +EE+ E+ + EK R + Q+
Sbjct: 653 EKMREQEEKMREQEE---------KMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEK 703
Query: 173 LKGKK----GKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKE-------PPKQGKEKA 221
+ G++ G+EEK G+ + + K + +++E +E + + +E PP K
Sbjct: 704 MWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPP--SKVLC 761
Query: 222 KKAEQGSEEEGEGEEEEEEGGESKADDPYA 251
+ GS E G E G S D+P A
Sbjct: 762 NMSHTGSVEPAGG----EAGEGSPQDNPTA 787
Score = 38.5 bits (88), Expect = 0.026
Identities = 41/144 (28%), Positives = 71/144 (49%), Gaps = 6/144 (4%)
Query: 157 EKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIK-EKEPPK 215
EK R+ ++ E Q +K K K E++K PQ + L E +EEE+ + EK+ K
Sbjct: 194 EKLRLAESEKSEIQLNVKELKRKLERAKFLL-PQVQTNTLQEEMWRQEEELREQEKKIRK 252
Query: 216 QGKEKAKKAEQGSEEEGEGEEEEEE--GGESKADDPYAHLSKKEK--KKLKKQMEYERQV 271
Q ++ ++ E+ E+EG+ E+EE+ E + + L ++EK ++ KK E E Q+
Sbjct: 253 QEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQM 312
Query: 272 ASLKAANAAENDFSVSQAEMSSRQ 295
+ + + Q E RQ
Sbjct: 313 QEQEEKMWEQEEKMREQEEKMWRQ 336
Score = 35.0 bits (79), Expect = 0.29
Identities = 18/77 (23%), Positives = 44/77 (57%), Gaps = 6/77 (7%)
Query: 537 KKMYQQKQK------ELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKN 590
+KM++Q+++ ++ +Q EK ++ K L+ K ++ EK+ +E ++Q+ + +
Sbjct: 255 EKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQE 314
Query: 591 QDEESQEAPELLKRPKE 607
Q+E+ E E ++ +E
Sbjct: 315 QEEKMWEQEEKMREQEE 331
Score = 34.3 bits (77), Expect = 0.50
Identities = 46/254 (18%), Positives = 117/254 (46%), Gaps = 33/254 (12%)
Query: 47 VEDKQAGEEEKV-LKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLS 105
++ K A +EK+ L E E+ + Q ++ K RK R K + + L E + +
Sbjct: 185 LKKKNAELQEKLRLAESEKSEIQLNVKELK----RKLERAKFLLPQVQTNTLQEEMWRQE 240
Query: 106 VPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
++E ++ + + ++ + L + + + E+EEK + ++ R+ +
Sbjct: 241 EELREQEKKIRKQEEKMWRQEE------RLREQEGKMREQEEK-----MRRQEKRLREQE 289
Query: 166 SE--EQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEE--DKEEEIIKEKEPPKQGKEKA 221
E EQ+ L+ +K E+ + + + K + EE+ ++EE++ +++E + +++
Sbjct: 290 KELREQEKELREQKKLREQEEQMQEQEEKM--WEQEEKMREQEEKMWRQEERLWEQEKQM 347
Query: 222 KKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAE 281
++ EQ ++ E E++E L +KE++ +++ +E++ + E
Sbjct: 348 REQEQKMRDQEERMWEQDE-----------RLREKEERMREQEKMWEQEEKMQEEERIRE 396
Query: 282 NDFSVSQAEMSSRQ 295
+ + + E + R+
Sbjct: 397 REKKMREEEETMRE 410
Score = 33.9 bits (76), Expect = 0.65
Identities = 19/70 (27%), Positives = 44/70 (62%), Gaps = 5/70 (7%)
Query: 541 QQKQKELLKQYEK---QEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQE 597
++++K++ KQ EK QE++L+E + GK +Q EK ++ ++Q+ + Q++E +E
Sbjct: 244 REQEKKIRKQEEKMWRQEERLREQE--GKMREQEEKMRRQEKRLREQEKELREQEKELRE 301
Query: 598 APELLKRPKE 607
+L ++ ++
Sbjct: 302 QKKLREQEEQ 311
Score = 32.0 bits (71), Expect = 2.5
Identities = 14/67 (20%), Positives = 41/67 (61%), Gaps = 5/67 (7%)
Query: 541 QQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPE 600
+++ +E K ++++EK +E K T++ EK+T + + +++ R + ++++ +E E
Sbjct: 520 EERMREQKKMWQQEEKMREE-----KKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 574
Query: 601 LLKRPKE 607
+++ +E
Sbjct: 575 MMREQEE 581
Score = 31.2 bits (69), Expect = 4.2
Identities = 20/74 (27%), Positives = 43/74 (58%), Gaps = 4/74 (5%)
Query: 537 KKMYQQKQKELLKQYEK---QEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDE 593
+KM++Q++K + +Q EK QE+K+ E + K +Q E ++ ++Q+ + Q+E
Sbjct: 595 EKMWEQEEK-MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEE 653
Query: 594 ESQEAPELLKRPKE 607
+ +E E ++ +E
Sbjct: 654 KMREQEEKMREQEE 667
Score = 30.4 bits (67), Expect = 7.2
Identities = 25/81 (30%), Positives = 46/81 (56%), Gaps = 8/81 (9%)
Query: 537 KKMYQQKQK--ELLKQYEKQEKKLKELKAGGKSTKQAEK-QTKEALTRKQQKC---RRKN 590
+KM++Q+++ E KQ +QE+K+++ + + +Q E+ + KE R+Q+K K
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEE--RMWEQDERLREKEERMREQEKMWEQEEKM 388
Query: 591 QDEESQEAPELLKRPKEYTVR 611
Q+EE E R +E T+R
Sbjct: 389 QEEERIREREKKMREEEETMR 409
Score = 30.0 bits (66), Expect = 9.4
Identities = 17/75 (22%), Positives = 43/75 (57%), Gaps = 13/75 (17%)
Query: 537 KKMYQQKQKELLKQYEK----QEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQD 592
+KM++Q++++ +++ E+ QE+K++E Q EK ++ ++Q+ + + Q+
Sbjct: 616 EKMWEQEEEDKMQEQEEMMWEQEEKMQE---------QEEKMWEQEEKMREQEEKMREQE 666
Query: 593 EESQEAPELLKRPKE 607
E+ Q E ++ +E
Sbjct: 667 EKMQGQEEKMREQEE 681
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 64.3 bits (155), Expect = 4e-10
Identities = 94/435 (21%), Positives = 181/435 (41%), Gaps = 45/435 (10%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFE---ELAVEDKQAGEEEKV----LKEKEQQQQQQ 69
D E DK ++ +++K + + E E+ VE+K +E+ LK + ++
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
Query: 70 QQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG----GKK 125
+Q++++++ + + + ++++ +E+ ER + ++E + + A + + +
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARL----EAEERERIKAEQDKKIADERAR 294
Query: 126 TKGGNVFAALIQDQSEEEEEEE-KHPPKPAKPEKNRIN---KAVSEEQQPALKGKKGKEE 181
+ AA +++ E EE E + K A E+ RI K +EE+Q +K ++ +
Sbjct: 295 IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ-RIKEEEKRAA 353
Query: 182 KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEG 241
+ + + K + K AA + + EEE + E K+ K+ +K E + +GE+ E++
Sbjct: 354 EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKI 413
Query: 242 GESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENA 301
++ A K + LKKQ E + K E+ + + E
Sbjct: 414 EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEE----------- 462
Query: 302 SDIKLEKFSISAHGKELFVNADLYIVAGRRYGLV---GPNGKGKTTLLKHIANRALSIPP 358
IK EK KE ++ R+ G NG+ T LKH N
Sbjct: 463 --IKDEKIKKDKEPKE-----EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 515
Query: 359 NIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEE 418
V E A+ P V+A R + R + E E +L+Q AA LE++ ++
Sbjct: 516 RASVDTKE----AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKK 571
Query: 419 LRATGAAAAEAKARR 433
E + RR
Sbjct: 572 REERRKVLEEEEQRR 586
Score = 63.5 bits (153), Expect = 8e-10
Identities = 93/427 (21%), Positives = 182/427 (42%), Gaps = 49/427 (11%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQ-AGEEEKVLK 60
PK +++ + I E DK + ++ + + A +DK+ A E ++
Sbjct: 238 PKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEA 297
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
E++ Q++++++ ++R+ + K+ ++ KE +R + +EE +
Sbjct: 298 EEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQ 357
Query: 121 RGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
R ++ K A + Q EEEEK AK E+ + NK + EE++ A++ K K
Sbjct: 358 RIKEEEK-----RAAEERQRARAEEEEK-----AKVEEQKRNKQL-EEKKHAMQETKIKG 406
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEE 240
EK + K + K+ +EDK + + +K+ ++G + K E+ E++ ++EE +
Sbjct: 407 EKVEQKI--EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK 464
Query: 241 GGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANA---------AENDFSVSQAEM 291
+ K D K+ K+++K M+ ++ +K+ N EN FS
Sbjct: 465 DEKIKKD-------KEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 517
Query: 292 SSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIAN 351
S E A ++ K L + RR G + LK
Sbjct: 518 SVDTKEAEGAPQVEAGK--------------RLEELRRRR----GETESEEFEKLKQKQQ 559
Query: 352 RALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAER 411
A + E+ V +E + AD ++L+ EE+RRL+ ++E+ AAE+
Sbjct: 560 EAALELEELKKKREERRKVLEEEEQRRKQEEAD-RKLREEEEKRRLKEEIERRRAEAAEK 618
Query: 412 LEKVYEE 418
+K+ E+
Sbjct: 619 RQKMPED 625
Score = 53.5 bits (127), Expect = 8e-07
Identities = 69/325 (21%), Positives = 139/325 (42%), Gaps = 28/325 (8%)
Query: 1 MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLK 60
+ +A ++Q I D + PS ++ +++ +K E E + E E V K
Sbjct: 111 LQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTK 170
Query: 61 EKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP 120
++ + ++ KK+ K+ +++ EEK + + V EE + +
Sbjct: 171 SYQKNDWRDAEENKKE--------DKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEE 222
Query: 121 RGGKKTKGGNVFAALIQDQSEEEE--EEEKHPPKPAKPEKNRIN------KAVSEEQQPA 172
K G + + + + E E+ +E H K + +K R +A E+ A
Sbjct: 223 TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282
Query: 173 LKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEE-EIIKEKEPPKQGKEKAKKAEQGSEEE 231
+ KK +E+++ +A + K AA + E + EE E ++E+E K A++ ++ EEE
Sbjct: 283 EQDKKIADERARIEA--EEKAAAQERERREAEERERMREEE-----KRAAEERQRIKEEE 335
Query: 232 GEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEM 291
EE + K ++ A ++ K+ +K+ ERQ A + A+ + ++
Sbjct: 336 KRAAEERQ---RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQL 392
Query: 292 SSRQAMLENASDIKLEKFSISAHGK 316
++ ++ + IK EK GK
Sbjct: 393 EEKKHAMQE-TKIKGEKVEQKIEGK 416
Score = 53.5 bits (127), Expect = 8e-07
Identities = 74/331 (22%), Positives = 149/331 (45%), Gaps = 61/331 (18%)
Query: 6 KQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQ 65
+++ E E + + E + ++ ++ K+++K + + E+K+A EE + +KE+E++
Sbjct: 308 RREAEERERMREEEKRAAEER--QRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
Query: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGG-- 123
+++Q+ + + + K V++ K+L E KK ++ + + E K G
Sbjct: 366 AAEERQRARAEEE-----EKAKVEEQKRNKQLEE--KKHAMQETKIKGEKVEQKIEGKWV 418
Query: 124 --KKTKGGNVFAALIQDQSEEE------EEEEKHPPKPA------KPEKNRINKAVSEEQ 169
KK + + A+++ Q EE+ + E+ KP K EK + +K EE
Sbjct: 419 NEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV 478
Query: 170 QPALKGKKG-KEEKSKG------KAK-PQNKF------AALDNEE--------------- 200
+ + KKG E KS+ K K +N F A++D +E
Sbjct: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE 538
Query: 201 ------EDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLS 254
E + EE K K+ ++ + ++ ++ EE + EEEE+ + + D
Sbjct: 539 LRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLR-E 597
Query: 255 KKEKKKLKKQMEYERQVASLKAANAAENDFS 285
++EK++LK+++E R A+ K E+ S
Sbjct: 598 EEEKRRLKEEIERRRAEAAEKRQKMPEDGLS 628
Score = 49.3 bits (116), Expect = 1e-05
Identities = 60/305 (19%), Positives = 130/305 (42%), Gaps = 54/305 (17%)
Query: 32 KKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDD 91
++ K+ + E + +EE+ +E+ ++ +Q++ +QK++ ++ G+ V+ +
Sbjct: 11 RRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEES-LGQVTDQVEVN 69
Query: 92 GEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTK-----------------------G 128
+ E K + T E D+ A R ++ +
Sbjct: 70 AQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDAS 129
Query: 129 GNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKA--------------VSEEQQPALK 174
++ + +Q+ + E E EK ++ E+ I + E ++ +
Sbjct: 130 LSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKE 189
Query: 175 GKKGKEEKSKGKAKPQNKFAALDNEE--EDKEEEIIK-------EKEPPKQGKEKAKKAE 225
++ +EEK K + +N+ + E+ E +EE ++ E PKQ +E+ E
Sbjct: 190 KEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEER----E 245
Query: 226 QGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFS 285
QGS+E E+ EEE E +A+ A L +E++++K E ++++A +A AE +
Sbjct: 246 QGSDEISHHEKMEEEDKE-RAEAERARLEAEERERIK--AEQDKKIADERARIEAEEKAA 302
Query: 286 VSQAE 290
+ E
Sbjct: 303 AQERE 307
Score = 36.2 bits (82), Expect = 0.13
Identities = 27/106 (25%), Positives = 57/106 (53%), Gaps = 9/106 (8%)
Query: 18 GESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKR 77
GE+ S + +K+ +++ ++ EEL K+ E KVL+E+EQ+++Q++ +K +
Sbjct: 544 GETESEEFEKLKQKQQEAALE---LEELK---KKREERRKVLEEEEQRRKQEEADRKLRE 597
Query: 78 DTRKGRRKKDVDDDGEEKELMERLKKLSVP-TSDEEDEVPAPKPRG 122
+ K R K+++ + E E+ +K+ SD++ P+G
Sbjct: 598 EEEKRRLKEEI--ERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKG 641
Score = 30.4 bits (67), Expect = 7.2
Identities = 21/72 (29%), Positives = 41/72 (56%), Gaps = 2/72 (2%)
Query: 536 FKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTK-EALTRKQQKCRRKNQDEE 594
F+K+ +QKQ+E + E+ +KK +E + + +Q KQ + + R++++ RR ++ E
Sbjct: 551 FEKL-KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIE 609
Query: 595 SQEAPELLKRPK 606
+ A KR K
Sbjct: 610 RRRAEAAEKRQK 621
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 63.9 bits (154), Expect = 6e-10
Identities = 60/280 (21%), Positives = 124/280 (44%), Gaps = 29/280 (10%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
+ S +KV + + +K K+ A K A +EK +E E++++ +++Q K +R+
Sbjct: 55 QQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKE-REHERRKRHREEQDKARRE 113
Query: 79 -TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
R+ RR+ + E++ +E+L E K R +K + +
Sbjct: 114 WERQKRREMAREHSRRERDRLEQL---------ERKRERERKMREQQKEQR--------E 156
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+ E EE+ + A+ E + ++ + E+ +K + P+ +F D
Sbjct: 157 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR---PPRERFELGD 213
Query: 198 -----NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAH 252
EE+ +E +++ + + + K AE S E G G EEEEE E + ++
Sbjct: 214 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--EEEEEEEEGS 271
Query: 253 LSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
S++ +++ +++ E E + S + ++ VS+ EMS
Sbjct: 272 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 311
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/228 (22%), Positives = 104/228 (45%), Gaps = 23/228 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
DK ++ ++ K+ + D+ E K +E++ ++QQ++Q+++K+R+ R R
Sbjct: 108 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 167
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA-------PKPRGGKKTKGGNVFAALIQ 137
+K+ + E +++ D D+V A P+P + G +
Sbjct: 168 RKEREARREVSAHHRTMRE------DYSDKVKASHWSRSPPRPPRERFELGDG------R 215
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+EE+ EE+ + + K S E A G +EE+ + + + + + +
Sbjct: 216 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 275
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+EEE++EE E+E + G + +EQ +EE E E E+E E++
Sbjct: 276 SEEEEEEE----EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 319
Score = 37.7 bits (86), Expect = 0.045
Identities = 36/207 (17%), Positives = 82/207 (39%), Gaps = 57/207 (27%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR------------KKDVDD----------- 90
E E+ ++E++++Q++Q++++++ + RK R ++D D
Sbjct: 142 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 201
Query: 91 -----------DG---------EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
DG EE++L+ L+ +S D E + + + + G
Sbjct: 202 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS----DSERKTSSAESSSAESGSGSE 257
Query: 131 VF----------AALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ ++ EEEEEEE+ + + ++ E + + + +E
Sbjct: 258 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 317
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEI 207
++ P+++F E E+ EEE+
Sbjct: 318 NENHLLVVPESRFDRDSGESEEAEEEV 344
Score = 33.5 bits (75), Expect = 0.85
Identities = 58/286 (20%), Positives = 119/286 (41%), Gaps = 54/286 (18%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
++P + P E +GDG K VK+ K +++ + ++++ +++ E E
Sbjct: 199 RSPPRPPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 252
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
++++++++++ + +G ++ +++ EE+E +EE+E G
Sbjct: 253 GSGSEEEEEEEEEEEE--EGSTSEESEEEEEEEE-------------EEEEET------G 291
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
+ A + ++ E+EE ++ +N + V E + G+ + E+
Sbjct: 292 SNSEEASEQSAEEVSEEEMSEDEEREN--------ENHL-LVVPESRFDRDSGESEEAEE 342
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG--SEEEGEGEEEEEE 240
G+ PQ+ +AL + + + E KQ K A QG S EE + EE
Sbjct: 343 EVGEGTPQS--SALTEGDYVPDSPALSPIE-LKQELPKYLPALQGCRSVEEFQCLNRIEE 399
Query: 241 G-------GESKADDPYAHLSKKEKKKLKKQMEYER-QVASLKAAN 278
G + K D L K+LK + E E + SL+ N
Sbjct: 400 GTYGVVYRAKDKKTDEIVAL-----KRLKMEKEKEGFPITSLREIN 440
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 63.9 bits (154), Expect = 6e-10
Identities = 60/280 (21%), Positives = 124/280 (44%), Gaps = 29/280 (10%)
Query: 19 ESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRD 78
+ S +KV + + +K K+ A K A +EK +E E++++ +++Q K +R+
Sbjct: 89 QQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKE-REHERRKRHREEQDKARRE 147
Query: 79 -TRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQ 137
R+ RR+ + E++ +E+L E K R +K + +
Sbjct: 148 WERQKRREMAREHSRRERDRLEQL---------ERKRERERKMREQQKEQR--------E 190
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+ E EE+ + A+ E + ++ + E+ +K + P+ +F D
Sbjct: 191 QKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR---PPRERFELGD 247
Query: 198 -----NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAH 252
EE+ +E +++ + + + K AE S E G G EEEEE E + ++
Sbjct: 248 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE--EEEEEEEEGS 305
Query: 253 LSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
S++ +++ +++ E E + S + ++ VS+ EMS
Sbjct: 306 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 345
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/228 (22%), Positives = 104/228 (45%), Gaps = 23/228 (10%)
Query: 25 DKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR 84
DK ++ ++ K+ + D+ E K +E++ ++QQ++Q+++K+R+ R R
Sbjct: 142 DKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEER 201
Query: 85 KKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA-------PKPRGGKKTKGGNVFAALIQ 137
+K+ + E +++ D D+V A P+P + G +
Sbjct: 202 RKEREARREVSAHHRTMRE------DYSDKVKASHWSRSPPRPPRERFELGDG------R 249
Query: 138 DQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALD 197
+EE+ EE+ + + K S E A G +EE+ + + + + + +
Sbjct: 250 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 309
Query: 198 NEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+EEE++EE E+E + G + +EQ +EE E E E+E E++
Sbjct: 310 SEEEEEEE----EEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENE 353
Score = 46.6 bits (109), Expect = 1e-04
Identities = 44/217 (20%), Positives = 101/217 (46%), Gaps = 17/217 (7%)
Query: 56 EKVLKEKEQQ-QQQQQQQQK--KKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
+++L+EK+++ +Q+++ + K K D R +R D EE EL + ++++ S
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR-----DSLEEGELRDHRMEITIRNSPYR 68
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172
E + +G + I+ + +E+ H K K ++ R +++ S E
Sbjct: 69 RE-------DSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKH 121
Query: 173 LKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEG 232
+ K+ + E + K + + A E K E+ +E ++ +++ ++ E+ E E
Sbjct: 122 ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHS--RRERDRLEQLERKRERER 179
Query: 233 EGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYER 269
+ E+++E E K + A +KE++ ++ + R
Sbjct: 180 KMREQQKEQREQKERERRAEERRKEREARREVSAHHR 216
Score = 37.7 bits (86), Expect = 0.045
Identities = 36/207 (17%), Positives = 82/207 (39%), Gaps = 57/207 (27%)
Query: 54 EEEKVLKEKEQQQQQQQQQQKKKRDTRKGRR------------KKDVDD----------- 90
E E+ ++E++++Q++Q++++++ + RK R ++D D
Sbjct: 176 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 235
Query: 91 -----------DG---------EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGN 130
DG EE++L+ L+ +S D E + + + + G
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS----DSERKTSSAESSSAESGSGSE 291
Query: 131 VF----------AALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKE 180
+ ++ EEEEEEE+ + + ++ E + + + +E
Sbjct: 292 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 351
Query: 181 EKSKGKAKPQNKFAALDNEEEDKEEEI 207
++ P+++F E E+ EEE+
Sbjct: 352 NENHLLVVPESRFDRDSGESEEAEEEV 378
Score = 33.5 bits (75), Expect = 0.85
Identities = 58/286 (20%), Positives = 119/286 (41%), Gaps = 54/286 (18%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
++P + P E +GDG K VK+ K +++ + ++++ +++ E E
Sbjct: 233 RSPPRPPRERFELGDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 286
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
++++++++++ + +G ++ +++ EE+E +EE+E G
Sbjct: 287 GSGSEEEEEEEEEEEE--EGSTSEESEEEEEEEE-------------EEEEET------G 325
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEK 182
+ A + ++ E+EE ++ +N + V E + G+ + E+
Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEEREN--------ENHL-LVVPESRFDRDSGESEEAEE 376
Query: 183 SKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQG--SEEEGEGEEEEEE 240
G+ PQ+ +AL + + + E KQ K A QG S EE + EE
Sbjct: 377 EVGEGTPQS--SALTEGDYVPDSPALSPIE-LKQELPKYLPALQGCRSVEEFQCLNRIEE 433
Query: 241 G-------GESKADDPYAHLSKKEKKKLKKQMEYER-QVASLKAAN 278
G + K D L K+LK + E E + SL+ N
Sbjct: 434 GTYGVVYRAKDKKTDEIVAL-----KRLKMEKEKEGFPITSLREIN 474
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 63.5 bits (153), Expect = 8e-10
Identities = 38/119 (31%), Positives = 62/119 (52%), Gaps = 9/119 (7%)
Query: 152 KPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEK 211
K K E + E++ +GK+ ++ K K K K + K + ++KEEE K K
Sbjct: 4 KKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRK 63
Query: 212 EPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
K+ KE+ ++ E+ EEE E EEEE+E G + KK+KK+ +K+ E E++
Sbjct: 64 RKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRR---------KKKKKRRRKEEEEEKK 113
Score = 61.6 bits (148), Expect = 3e-09
Identities = 40/128 (31%), Positives = 68/128 (53%), Gaps = 18/128 (14%)
Query: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAAL 196
++ E EEEEEK + K ++ R K ++ + K K+ +EE+ K K K + K
Sbjct: 14 EETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEE 73
Query: 197 DNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKK 256
+ EEE++EEE KE+E ++G+ + KK ++ +EE EEE++ KK
Sbjct: 74 EREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEE---EEEKK---------------KK 115
Query: 257 EKKKLKKQ 264
++K KK+
Sbjct: 116 RRRKTKKK 123
Score = 59.7 bits (143), Expect = 1e-08
Identities = 45/154 (29%), Positives = 78/154 (50%), Gaps = 31/154 (20%)
Query: 33 KDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDG 92
K KK KK EE ++ EEEK K KE++++++++++KKK+ T++ ++K+ +++
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKK-TKETEKRKEKEEE- 58
Query: 93 EEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPK 152
E+K +R KK +EE+E ++ EE+EEEEK +
Sbjct: 59 EKKRKRKRKKKKEEEEREEEEE-----------------------EEEEEKEEEEKEEGR 95
Query: 153 PAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGK 186
K +K R K EE+ KK + K+K K
Sbjct: 96 RRKKKKKRRRKEEEEEK------KKKRRRKTKKK 123
Score = 53.1 bits (126), Expect = 1e-06
Identities = 34/112 (30%), Positives = 57/112 (50%), Gaps = 15/112 (13%)
Query: 174 KGKKGK---------------EEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGK 218
K KK K EE+ +GK K + K + E++ K +E K KE ++ K
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEK 60
Query: 219 EKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQ 270
++ +K ++ EEE EEEEEE E + ++ +K+KKK +++ E E +
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEK 112
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/156 (24%), Positives = 78/156 (50%), Gaps = 34/156 (21%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K K++ E E + E T ++ K+GK+ +K K E ++ E++K KE
Sbjct: 1 KKKKKKKKETEETEETEETEEEEE--KEGKRKEKRK---------EKRKEKEKKKKTKET 49
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRG 122
E++++++++++K+KR +K + +++ +++ EE+E +E++E + R
Sbjct: 50 EKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEE-------------EEKEEEEKEEGRR 96
Query: 123 GKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEK 158
KK K + +EEEEEK + K +K
Sbjct: 97 RKKKK----------KRRRKEEEEEKKKKRRRKTKK 122
Score = 45.1 bits (105), Expect = 3e-04
Identities = 35/151 (23%), Positives = 73/151 (48%), Gaps = 36/151 (23%)
Query: 56 EKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEV 115
+K K+K++ ++ ++ ++ ++ + ++G+RK+ + +EKE KK
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKE-----KK------------ 43
Query: 116 PAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKG 175
KKTK + + E+EEEE+K K K ++ + EE++
Sbjct: 44 --------KKTKE-------TEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEE---- 84
Query: 176 KKGKEEKSKGKAKPQNKFAALDNEEEDKEEE 206
+K +EEK +G+ + + K EEE+K+++
Sbjct: 85 EKEEEEKEEGRRRKKKKKRRRKEEEEEKKKK 115
Score = 41.2 bits (95), Expect = 0.004
Identities = 21/101 (20%), Positives = 60/101 (59%), Gaps = 2/101 (1%)
Query: 3 KAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEK 62
K K++ E + E + + K+ +K+++ KK + ++++ EEE+ +E+
Sbjct: 25 KEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEE--EEE 82
Query: 63 EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKK 103
E++++++++++ ++R +K RR+K+ +++ ++K + KK
Sbjct: 83 EEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKTKKK 123
Score = 38.9 bits (89), Expect = 0.020
Identities = 20/65 (30%), Positives = 37/65 (56%)
Query: 543 KQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELL 602
K+KE K+ K+++K K+ K K ++ E++ K RK++K + ++EE +E E
Sbjct: 28 KRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKE 87
Query: 603 KRPKE 607
+ KE
Sbjct: 88 EEEKE 92
Score = 36.2 bits (82), Expect = 0.13
Identities = 24/100 (24%), Positives = 44/100 (44%)
Query: 209 KEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYE 268
K+K+ K+ +E + E EEE EG+ +E+ + K + + EK+K K++ E +
Sbjct: 2 KKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKK 61
Query: 269 RQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEK 308
R+ K E + + E + E K +K
Sbjct: 62 RKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKK 101
Score = 36.2 bits (82), Expect = 0.13
Identities = 22/80 (27%), Positives = 43/80 (53%), Gaps = 9/80 (11%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQ---------QKCR 587
K+ + ++ E ++ E++E K KE + + K+ +K+TKE RK+ +K +
Sbjct: 8 KETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRK 67
Query: 588 RKNQDEESQEAPELLKRPKE 607
+K ++EE +E E + KE
Sbjct: 68 KKKEEEEREEEEEEEEEEKE 87
Score = 36.2 bits (82), Expect = 0.13
Identities = 24/97 (24%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query: 199 EEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEK 258
E E+ EE E+E K+GK K K+ E+ E+E + + +E E + K ++ EK
Sbjct: 9 ETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEE--------EK 60
Query: 259 KKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQ 295
K+ +K+ + + + + E + + E R+
Sbjct: 61 KRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRR 97
Score = 35.8 bits (81), Expect = 0.17
Identities = 17/71 (23%), Positives = 43/71 (60%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
K+ ++++K K+ +K+E++ +E + + ++ E++ +E RK++K RR+ ++EE +
Sbjct: 53 KEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEK 112
Query: 597 EAPELLKRPKE 607
+ K K+
Sbjct: 113 KKKRRRKTKKK 123
Score = 35.4 bits (80), Expect = 0.22
Identities = 22/70 (31%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 538 KMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQE 597
K ++K+KE + E +E + +E K G + K+ EK+ KE +K+ K K +++E +E
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKR-KEKEKKKKTKETEKRKEKEEEE 59
Query: 598 APELLKRPKE 607
KR K+
Sbjct: 60 KKRKRKRKKK 69
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/71 (28%), Positives = 42/71 (59%), Gaps = 2/71 (2%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
K+ ++K+KE K+ ++ EK+ KE + K K+ K+ KE R++++ + +++E +
Sbjct: 32 KRKEKRKEKEKKKKTKETEKR-KEKEEEEKKRKRKRKKKKEEEEREEEE-EEEEEEKEEE 89
Query: 597 EAPELLKRPKE 607
E E +R K+
Sbjct: 90 EKEEGRRRKKK 100
Score = 31.6 bits (70), Expect = 3.2
Identities = 15/71 (21%), Positives = 41/71 (57%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
K+ ++K+K+ + +++EK+ +E K K K+ E++ +E ++++ + + + EE +
Sbjct: 36 KRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGR 95
Query: 597 EAPELLKRPKE 607
+ KR ++
Sbjct: 96 RRKKKKKRRRK 106
Score = 30.8 bits (68), Expect = 5.5
Identities = 14/70 (20%), Positives = 43/70 (61%)
Query: 537 KKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQ 596
+K +++++E ++ ++++KK +E + + ++ EK+ +E +++K ++K + +E +
Sbjct: 50 EKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109
Query: 597 EAPELLKRPK 606
E + +R K
Sbjct: 110 EEKKKKRRRK 119
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 62.4 bits (150), Expect = 2e-09
Identities = 58/185 (31%), Positives = 90/185 (48%), Gaps = 20/185 (10%)
Query: 329 GRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRL 388
G LVGPNG GK+T+ + N L P +LL D P Q R +++
Sbjct: 591 GEVTALVGPNGSGKSTVAALLQN--LYQPTGGQLLL-------DGKPLPQYEHRYLHRQV 641
Query: 389 KLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGL--GFDPEMQN 446
+ +E ++ G+ Q + + EE+ A AA ++ A ++GL G+D E+
Sbjct: 642 AAVGQEPQVFGRSLQENIAYGLTQKPTMEEITA---AAVKSGAHSFISGLPQGYDTEVDE 698
Query: 447 RPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYL-----QGWRKTL 501
+Q SGG R V+LARAL +P +L+LD+ T+ LD N+ + + L + R L
Sbjct: 699 AGSQ-LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVL 757
Query: 502 LIVSH 506
LI H
Sbjct: 758 LITQH 762
Score = 52.4 bits (124), Expect = 2e-06
Identities = 60/236 (25%), Positives = 97/236 (41%), Gaps = 45/236 (19%)
Query: 612 FTFPDPPPLSPPV-----LGLHG------VTFGYQGQKPLF--KNLDFGIDMDSRICIVG 658
F + D P PP L L G V+F Y + + + L F + +VG
Sbjct: 539 FEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVG 598
Query: 659 PNGVGKSTLLLLLTGKLTPTHGEM--------RKNHRLKIGFFNQQYAEQLRMEETPTEY 710
PNG GKST+ LL PT G++ + HR + ++Q A + +
Sbjct: 599 PNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHR----YLHRQVAAVGQEPQVFGRS 654
Query: 711 LQRG--FNLPYQDARKCLGRFGLESHAHTIQI--------------CKLSGGQKARVVFA 754
LQ + L + + + ++S AH+ +LSGGQ+ V A
Sbjct: 655 LQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALA 714
Query: 755 ELACREPDVLILDEPTNNLDIES----IDALGEAINEYKGAVIVVSHDARLITETN 806
R+P VLILD+ T+ LD S L E+ Y +V++++ L+ + +
Sbjct: 715 RALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQAD 770
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 62.4 bits (150), Expect = 2e-09
Identities = 71/300 (23%), Positives = 122/300 (40%), Gaps = 47/300 (15%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
D + P +++ KK ++ IK + ED + +E E+ +++ +Q ++
Sbjct: 1223 DDDDNDPENRIAKKMLLEE-IKANLSSD---EDGSSDDEP----EEGKKRTGKQNEENPG 1274
Query: 77 RDTRKGRRKKDVDDDGEEKE---LMERLKKLSVPTSD-EEDEVPAPKPRGGKKTKGGNVF 132
+ K + + D D EE + RL + + SD E E KP+ K+ KG N
Sbjct: 1275 DEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRR 1334
Query: 133 AALIQDQSEEE------EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE-KSKG 185
+D + + EE +P KA EE Q + K KK + K +
Sbjct: 1335 KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQE 1394
Query: 186 KAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+ +NK N EE++EE K E+ EEE E EEEE+E +SK
Sbjct: 1395 DSSSENK----SNSEEEEEE-----------------KEEEEEEEEEEEEEEEDENDDSK 1433
Query: 246 ADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIK 305
+ K +KK++K ++ ++ + A E + AE + L +I+
Sbjct: 1434 SPG-------KGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIE 1486
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 49/243 (20%)
Query: 6 KQQPPEPEWIGDGES----TSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
KQ P GD E+ S SD ++ KK + + +L V D ++GEE+K
Sbjct: 1267 KQNEENP---GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT--- 1320
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
+ K+ ++ + R+K +D E+ + E +S S+ EDE P+ R
Sbjct: 1321 ----------KPKEHKEVKGRNRRKVSSEDSEDSDFQE--SGVSEEVSESEDE-QRPRTR 1367
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
KK + +++ ++++K + + + NK+ SEE++ + ++ +EE
Sbjct: 1368 SAKKAE--------LEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1419
Query: 182 -------------KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGS 228
KS GK + + + D++ + + +KE+E + + + AE+
Sbjct: 1420 EEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEE-----ERRKRIAERER 1474
Query: 229 EEE 231
E E
Sbjct: 1475 ERE 1477
Score = 47.8 bits (112), Expect = 4e-05
Identities = 42/225 (18%), Positives = 99/225 (44%), Gaps = 16/225 (7%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDV 88
K +K + + E+ ++++ +K LK E ++++ ++ ++ + G D
Sbjct: 1061 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDA 1120
Query: 89 DDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEK 148
++ E+ + KK +S ++ + K R +T A + S + E++++
Sbjct: 1121 EESSEDNK-----KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1175
Query: 149 HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEII 208
+ ++ +I K V+E L G + S +A ++ +D++++D + E
Sbjct: 1176 NSIGEGSSDEQKI-KPVTENL--VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPE-- 1230
Query: 209 KEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEG----GESKADDP 249
K+ + KA S+E+G ++E EEG G+ ++P
Sbjct: 1231 --NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENP 1273
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/278 (20%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK 85
KV + +K K +K ++ V+D + EK LK+ + + + +++ K+ T + ++
Sbjct: 900 KVAETKEKSKHLKTKTCKK--VQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 957
Query: 86 KDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEE 145
D K+ + ++++ +SD +++P E E
Sbjct: 958 SDF------KKKVIKMEQQYESSSDGTEKLP--------------------------ERE 985
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEE 205
E H PK K KN + ++ K K K+E S K K + D+ E+ K +
Sbjct: 986 EICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSK 1045
Query: 206 E--IIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKL-- 261
+EK+ K + ++K + S + E +E+G S +D + +E++ L
Sbjct: 1046 NGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNS-SDKRLKRIELRERRNLSS 1104
Query: 262 -KKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAML 298
+ E + +S A ++E++ Q S ++A++
Sbjct: 1105 KRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI 1142
Score = 45.8 bits (107), Expect = 2e-04
Identities = 51/213 (23%), Positives = 90/213 (42%), Gaps = 35/213 (16%)
Query: 15 IGDGES-----TSPSDKVVKKGKKDKKI-----KKTFFEELAVEDKQAGEEE------KV 58
+ DGES T P + KG+ +K+ + + F+E V ++ + E+ +
Sbjct: 1309 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1368
Query: 59 LKEKEQQQQQQQQQQKKKR------DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
K+ E ++ Q+ +QKKKR + K + +++ EEKE E ++ +EE
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKE--EEEEEEEEEEEEEE 1426
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172
DE K G KG +++D E + A E+ K ++E ++
Sbjct: 1427 DENDDSKSPG----KGRKKIRKILKDDKLRTETQN------ALKEEEERRKRIAERERER 1476
Query: 173 LKGKKGKEEKSKGKAK-PQNKFAALDNEEEDKE 204
K ++ E + K P LD +EE KE
Sbjct: 1477 EKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1509
Score = 42.0 bits (97), Expect = 0.002
Identities = 59/310 (19%), Positives = 117/310 (37%), Gaps = 45/310 (14%)
Query: 15 IGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQK 74
I G S+S +++ + KK K+ + ++K + KE+++ + K
Sbjct: 1111 IQSGSSSSDAEESSEDNKKKKQ--------------RTSSKKKAVIVKEKKRNSLRTSTK 1156
Query: 75 KKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP------RGGKKTKG 128
+K+ D++DD + + +SDE+ P + G ++ G
Sbjct: 1157 RKQADITSSSSSDIEDDDQNS--------IGEGSSDEQKIKPVTENLVLSSHTGFCQSSG 1208
Query: 129 GNVFAALIQ---DQSEEEEEEEKHPPKPAKPEKNRINKAVSE--------EQQPALKGKK 177
+ + D +++ + E K E+ + N + E E+ GK+
Sbjct: 1209 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1268
Query: 178 GKEEKSKGKAKPQ-NKFAALDNEEEDK---EEEIIKEKEPPKQGKE-KAKKAEQGSEEEG 232
+E +AK Q N + D+EE K +++ K G+ + KK + +E
Sbjct: 1269 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1328
Query: 233 EGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
+G + E D + E+ + + E + S K A EN S Q +
Sbjct: 1329 KGRNRRKVSSEDSEDSDFQESGVSEEVS-ESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1387
Query: 293 SRQAMLENAS 302
R + E++S
Sbjct: 1388 RRIKVQEDSS 1397
Score = 38.9 bits (89), Expect = 0.020
Identities = 52/277 (18%), Positives = 102/277 (36%), Gaps = 28/277 (10%)
Query: 58 VLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
V K+ ++ K K ++ + VD + + E++ LK++S + +
Sbjct: 657 VRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDI 716
Query: 118 P------------KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
K + GK KG + S+ + ++ K +K R ++
Sbjct: 717 NEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSG-SDFDTKKGKSAKSSIISKKKRQTQSE 775
Query: 166 SEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAE 225
S L+ K+ K G A+ K + + E+E +K QG + K ++
Sbjct: 776 SSNYDSELE-KEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 834
Query: 226 QGSEEEGEGEEEEE--EGGESKADDPYAHLSKKEKKKLKKQME-----------YERQVA 272
+GS ++ E ++E E E D + +++ K+Q E+
Sbjct: 835 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 894
Query: 273 SLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKF 309
SL+ AE + + + + + SDI EKF
Sbjct: 895 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDI-AEKF 930
Score = 30.8 bits (68), Expect = 5.5
Identities = 23/94 (24%), Positives = 43/94 (45%), Gaps = 7/94 (7%)
Query: 157 EKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEII----KEKE 212
+ +++ V E+Q K G+ +KS K +PQ + A N ED + +I+ E
Sbjct: 432 DSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA---NTSEDLDMDIVSVPSSVPE 488
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKA 246
+ E A + + + +G+G E+ ES +
Sbjct: 489 DIFENLETAMEVQSSVDHQGDGSSGTEQEVESSS 522
Score = 30.0 bits (66), Expect = 9.4
Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 11/92 (11%)
Query: 179 KEEKSKGKAKPQNKFAALDNEEED---KEEEIIKEKEPPKQGKEKAKKAEQGSEEEGE-- 233
KE K ++F A D++E ++ K+K+ K+GK+ + + GS+ + E
Sbjct: 1858 KENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVI 1917
Query: 234 --GEEEEEEGGESKADD----PYAHLSKKEKK 259
GGE D+ P L +E K
Sbjct: 1918 KVWNSRSRGGGEGNVDETGNNPSVSLKLEESK 1949
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 62.4 bits (150), Expect = 2e-09
Identities = 71/300 (23%), Positives = 122/300 (40%), Gaps = 47/300 (15%)
Query: 17 DGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKK 76
D + P +++ KK ++ IK + ED + +E E+ +++ +Q ++
Sbjct: 1261 DDDDNDPENRIAKKMLLEE-IKANLSSD---EDGSSDDEP----EEGKKRTGKQNEENPG 1312
Query: 77 RDTRKGRRKKDVDDDGEEKE---LMERLKKLSVPTSD-EEDEVPAPKPRGGKKTKGGNVF 132
+ K + + D D EE + RL + + SD E E KP+ K+ KG N
Sbjct: 1313 DEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRR 1372
Query: 133 AALIQDQSEEE------EEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE-KSKG 185
+D + + EE +P KA EE Q + K KK + K +
Sbjct: 1373 KVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQE 1432
Query: 186 KAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESK 245
+ +NK N EE++EE K E+ EEE E EEEE+E +SK
Sbjct: 1433 DSSSENK----SNSEEEEEE-----------------KEEEEEEEEEEEEEEEDENDDSK 1471
Query: 246 ADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIK 305
+ K +KK++K ++ ++ + A E + AE + L +I+
Sbjct: 1472 SPG-------KGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIE 1524
Score = 49.7 bits (117), Expect = 1e-05
Identities = 53/243 (21%), Positives = 105/243 (43%), Gaps = 49/243 (20%)
Query: 6 KQQPPEPEWIGDGES----TSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
KQ P GD E+ S SD ++ KK + + +L V D ++GEE+K
Sbjct: 1305 KQNEENP---GDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKT--- 1358
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
+ K+ ++ + R+K +D E+ + E +S S+ EDE P+ R
Sbjct: 1359 ----------KPKEHKEVKGRNRRKVSSEDSEDSDFQE--SGVSEEVSESEDE-QRPRTR 1405
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
KK + +++ ++++K + + + NK+ SEE++ + ++ +EE
Sbjct: 1406 SAKKAE--------LEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEE 1457
Query: 182 -------------KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGS 228
KS GK + + + D++ + + +KE+E + + + AE+
Sbjct: 1458 EEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEE-----ERRKRIAERER 1512
Query: 229 EEE 231
E E
Sbjct: 1513 ERE 1515
Score = 47.8 bits (112), Expect = 4e-05
Identities = 42/225 (18%), Positives = 99/225 (44%), Gaps = 16/225 (7%)
Query: 29 KKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDV 88
K +K + + E+ ++++ +K LK E ++++ ++ ++ + G D
Sbjct: 1099 KSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDA 1158
Query: 89 DDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEK 148
++ E+ + KK +S ++ + K R +T A + S + E++++
Sbjct: 1159 EESSEDNK-----KKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQ 1213
Query: 149 HPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEII 208
+ ++ +I K V+E L G + S +A ++ +D++++D + E
Sbjct: 1214 NSIGEGSSDEQKI-KPVTENL--VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPE-- 1268
Query: 209 KEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEG----GESKADDP 249
K+ + KA S+E+G ++E EEG G+ ++P
Sbjct: 1269 --NRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENP 1311
Score = 46.6 bits (109), Expect = 1e-04
Identities = 56/278 (20%), Positives = 117/278 (42%), Gaps = 40/278 (14%)
Query: 26 KVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRK 85
KV + +K K +K ++ V+D + EK LK+ + + + +++ K+ T + ++
Sbjct: 938 KVAETKEKSKHLKTKTCKK--VQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKP 995
Query: 86 KDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEE 145
D K+ + ++++ +SD +++P E E
Sbjct: 996 SDF------KKKVIKMEQQYESSSDGTEKLP--------------------------ERE 1023
Query: 146 EEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEE 205
E H PK K KN + ++ K K K+E S K K + D+ E+ K +
Sbjct: 1024 EICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSK 1083
Query: 206 E--IIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKL-- 261
+EK+ K + ++K + S + E +E+G S +D + +E++ L
Sbjct: 1084 NGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNS-SDKRLKRIELRERRNLSS 1142
Query: 262 -KKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAML 298
+ E + +S A ++E++ Q S ++A++
Sbjct: 1143 KRNTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI 1180
Score = 45.8 bits (107), Expect = 2e-04
Identities = 51/213 (23%), Positives = 90/213 (42%), Gaps = 35/213 (16%)
Query: 15 IGDGES-----TSPSDKVVKKGKKDKKI-----KKTFFEELAVEDKQAGEEE------KV 58
+ DGES T P + KG+ +K+ + + F+E V ++ + E+ +
Sbjct: 1347 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRS 1406
Query: 59 LKEKEQQQQQQQQQQKKKR------DTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112
K+ E ++ Q+ +QKKKR + K + +++ EEKE E ++ +EE
Sbjct: 1407 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKE--EEEEEEEEEEEEEE 1464
Query: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172
DE K G KG +++D E + A E+ K ++E ++
Sbjct: 1465 DENDDSKSPG----KGRKKIRKILKDDKLRTETQN------ALKEEEERRKRIAERERER 1514
Query: 173 LKGKKGKEEKSKGKAK-PQNKFAALDNEEEDKE 204
K ++ E + K P LD +EE KE
Sbjct: 1515 EKLREVIEIEDASPTKCPITTKLVLDEDEETKE 1547
Score = 42.0 bits (97), Expect = 0.002
Identities = 59/310 (19%), Positives = 117/310 (37%), Gaps = 45/310 (14%)
Query: 15 IGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQK 74
I G S+S +++ + KK K+ + ++K + KE+++ + K
Sbjct: 1149 IQSGSSSSDAEESSEDNKKKKQ--------------RTSSKKKAVIVKEKKRNSLRTSTK 1194
Query: 75 KKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKP------RGGKKTKG 128
+K+ D++DD + + +SDE+ P + G ++ G
Sbjct: 1195 RKQADITSSSSSDIEDDDQNS--------IGEGSSDEQKIKPVTENLVLSSHTGFCQSSG 1246
Query: 129 GNVFAALIQ---DQSEEEEEEEKHPPKPAKPEKNRINKAVSE--------EQQPALKGKK 177
+ + D +++ + E K E+ + N + E E+ GK+
Sbjct: 1247 DEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQ 1306
Query: 178 GKEEKSKGKAKPQ-NKFAALDNEEEDK---EEEIIKEKEPPKQGKE-KAKKAEQGSEEEG 232
+E +AK Q N + D+EE K +++ K G+ + KK + +E
Sbjct: 1307 NEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEV 1366
Query: 233 EGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMS 292
+G + E D + E+ + + E + S K A EN S Q +
Sbjct: 1367 KGRNRRKVSSEDSEDSDFQESGVSEEVS-ESEDEQRPRTRSAKKAELEENQRSYKQKKKR 1425
Query: 293 SRQAMLENAS 302
R + E++S
Sbjct: 1426 RRIKVQEDSS 1435
Score = 38.9 bits (89), Expect = 0.020
Identities = 52/277 (18%), Positives = 102/277 (36%), Gaps = 28/277 (10%)
Query: 58 VLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPA 117
V K+ ++ K K ++ + VD + + E++ LK++S + +
Sbjct: 695 VRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDI 754
Query: 118 P------------KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAV 165
K + GK KG + S+ + ++ K +K R ++
Sbjct: 755 NEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSG-SDFDTKKGKSAKSSIISKKKRQTQSE 813
Query: 166 SEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAE 225
S L+ K+ K G A+ K + + E+E +K QG + K ++
Sbjct: 814 SSNYDSELE-KEIKSMSKIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQ 872
Query: 226 QGSEEEGEGEEEEE--EGGESKADDPYAHLSKKEKKKLKKQME-----------YERQVA 272
+GS ++ E ++E E E D + +++ K+Q E+
Sbjct: 873 EGSSDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFT 932
Query: 273 SLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKF 309
SL+ AE + + + + + SDI EKF
Sbjct: 933 SLEVRKVAETKEKSKHLKTKTCKKVQDGLSDI-AEKF 968
Score = 30.8 bits (68), Expect = 5.5
Identities = 23/94 (24%), Positives = 43/94 (45%), Gaps = 7/94 (7%)
Query: 157 EKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEII----KEKE 212
+ +++ V E+Q K G+ +KS K +PQ + A N ED + +I+ E
Sbjct: 470 DSEHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEPA---NTSEDLDMDIVSVPSSVPE 526
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKA 246
+ E A + + + +G+G E+ ES +
Sbjct: 527 DIFENLETAMEVQSSVDHQGDGSSGTEQEVESSS 560
Score = 30.0 bits (66), Expect = 9.4
Identities = 23/92 (25%), Positives = 39/92 (42%), Gaps = 11/92 (11%)
Query: 179 KEEKSKGKAKPQNKFAALDNEEED---KEEEIIKEKEPPKQGKEKAKKAEQGSEEEGE-- 233
KE K ++F A D++E ++ K+K+ K+GK+ + + GS+ + E
Sbjct: 1896 KENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKDSSSSGSGSDNDVEVI 1955
Query: 234 --GEEEEEEGGESKADD----PYAHLSKKEKK 259
GGE D+ P L +E K
Sbjct: 1956 KVWNSRSRGGGEGNVDETGNNPSVSLKLEESK 1987
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 61.6 bits (148), Expect = 3e-09
Identities = 64/279 (22%), Positives = 117/279 (41%), Gaps = 61/279 (21%)
Query: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKK 125
+++++ +QK ++D R+ +RK EKE + + S+PT +ED PA +
Sbjct: 637 EEERRHRQKLEKDKRRKKRK--------EKEKKGKRRHSSLPTESDEDIAPAQQV----- 683
Query: 126 TKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE-EQQPALKGKKGKEEKS- 183
++ + + + +E++K P P + ++K +++ E+ P K + + KS
Sbjct: 684 ----DIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSP 739
Query: 184 --------KGKAKPQNKFAALDNEEEDKEEEIIKEKE----------------------- 212
K KP+ K +E DKE++ KEK+
Sbjct: 740 EKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPV 799
Query: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKE-----KKKLKKQMEY 267
P E AK QG E++ EG++++++ + K H +KE KKK KKQ
Sbjct: 800 PSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKK---KHRKEKEERTKGKKKSKKQPPG 856
Query: 268 ERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKL 306
+ A N A + Q S ++L S +K+
Sbjct: 857 SEEAAGEPVQNGAPEE---EQLPPESSYSLLAENSYVKM 892
Score = 38.9 bits (89), Expect = 0.020
Identities = 49/230 (21%), Positives = 79/230 (34%), Gaps = 75/230 (32%)
Query: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
P A ++ P + S SP V KK KK KK +EK KE
Sbjct: 718 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK---------------KEKKHKE 762
Query: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
KE+ ++++++++KK D + T+ PAP P
Sbjct: 763 KERDKEKKKEKEKKAEDL-----------------------DFWLSTTPPPAPAPAPAPV 799
Query: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
A ++ E ++++K PKP K K +K KEE
Sbjct: 800 PSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKK-----------------KHRKEKEE 842
Query: 182 KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEE 231
++KGK K +K+PP + + + G+ EE
Sbjct: 843 RTKGKKK--------------------SKKQPPGSEEAAGEPVQNGAPEE 872
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.130 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,082,888
Number of Sequences: 37866
Number of extensions: 1990719
Number of successful extensions: 54756
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 846
Number of HSP's successfully gapped in prelim test: 1368
Number of HSP's that attempted gapping in prelim test: 15736
Number of HSP's gapped (non-prelim): 17468
length of query: 845
length of database: 18,247,518
effective HSP length: 111
effective length of query: 734
effective length of database: 14,044,392
effective search space: 10308583728
effective search space used: 10308583728
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.