Search of human proteins with 6912506

Search of human proteins with 6912506

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]
         (263 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]       525   e-149
gi|4502179 aquaporin 2 [Homo sapiens]                                 326   1e-89
gi|4502183 aquaporin 5 [Homo sapiens]                                 281   3e-76
gi|86792455 aquaporin 6 [Homo sapiens]                                254   4e-68
gi|4755125 aquaporin 4 isoform b [Homo sapiens]                       237   9e-63
gi|4502181 aquaporin 4 isoform a [Homo sapiens]                       237   9e-63
gi|37694062 aquaporin 1 [Homo sapiens]                                233   2e-61
gi|45446752 aquaporin 8 [Homo sapiens]                                112   3e-25
gi|4502187 aquaporin 7 [Homo sapiens]                                  87   1e-17
gi|157266307 aquaporin 9 [Homo sapiens]                                81   1e-15
gi|4826645 aquaporin 3 [Homo sapiens]                                  76   3e-14
gi|22538420 aquaporin 10 [Homo sapiens]                                58   1e-08
gi|4507047 solute carrier family 7 (cationic amino acid transpor...    30   1.6  
gi|4557535 solute carrier family 26, member 3 [Homo sapiens]           30   2.1  
gi|114326550 solute carrier family 7 (cationic amino acid transp...    30   2.8  
gi|114326544 solute carrier family 7 (cationic amino acid transp...    30   2.8  
gi|40538880 aquaporin 12A [Homo sapiens]                               30   2.8  
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s...    29   4.8  
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s...    29   4.8  
gi|6005794 PRA1 domain family, member 2 [Homo sapiens]                 29   4.8  
gi|62526026 cutA divalent cation tolerance homolog isoform 3 [Ho...    29   4.8  
gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4 ...    28   6.2  
gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [H...    28   6.2  
gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3 ...    28   8.2  
gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2 ...    28   8.2  
gi|7108340 deoxyhypusine synthase isoform c [Homo sapiens]             28   8.2  
gi|156447037 aquaporin 12B [Homo sapiens]                              28   8.2  

>gi|6912506 major intrinsic protein of lens fiber [Homo sapiens]
          Length = 263

 Score =  525 bits (1352), Expect = e-149
 Identities = 263/263 (100%), Positives = 263/263 (100%)

Query: 1   MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG 60
           MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG
Sbjct: 1   MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG 60

Query: 61  HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT 120
           HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT
Sbjct: 61  HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT 120

Query: 121 LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG 180
           LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG
Sbjct: 121 LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG 180

Query: 181 AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA 240
           AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA
Sbjct: 181 AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA 240

Query: 241 KPDVSNGQPEVTGEPVELNTQAL 263
           KPDVSNGQPEVTGEPVELNTQAL
Sbjct: 241 KPDVSNGQPEVTGEPVELNTQAL 263


>gi|4502179 aquaporin 2 [Homo sapiens]
          Length = 271

 Score =  326 bits (836), Expect = 1e-89
 Identities = 161/261 (61%), Positives = 206/261 (78%), Gaps = 1/261 (0%)

Query: 1   MWELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVG 60
           MWELRS +F RA+FAEF ATL +VFFGLGS+L W      VLQ+AMAFGL + TLVQ++G
Sbjct: 1   MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALG 60

Query: 61  HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNT 120
           HISGAH+NPAVT A LVG  +S+LRA  Y+AAQLLGAVAGAA+L+ +TP  +RG+LA+N 
Sbjct: 61  HISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNA 120

Query: 121 LHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTG 180
           L  + + GQA TVE+FLTLQ VLCIFA+ DERR    G+ AL++GFS+ALGHL G++YTG
Sbjct: 121 LSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTG 180

Query: 181 AGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA 240
             MNPARS APA++TG F +HWV+W+GP++G  LGSLLY+++LFP  KS+SERL+VLKG 
Sbjct: 181 CSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGL 240

Query: 241 KPDVSNGQPEV-TGEPVELNT 260
           +PD    + EV   + VEL++
Sbjct: 241 EPDTDWEEREVRRRQSVELHS 261


>gi|4502183 aquaporin 5 [Homo sapiens]
          Length = 265

 Score =  281 bits (720), Expect = 3e-76
 Identities = 140/262 (53%), Positives = 190/262 (72%), Gaps = 3/262 (1%)

Query: 3   ELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHI 62
           E+ S +F +A+FAEF ATL +VFFGLGS+L+W      +LQ+A+AFGLA+ TL Q++G +
Sbjct: 4   EVCSVAFLKAVFAEFLATLIFVFFGLGSALKWPSALPTILQIALAFGLAIGTLAQALGPV 63

Query: 63  SGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLH 122
           SG H+NPA+T A LVG+Q+SLLRAF Y+AAQL+GA+AGA +LY V P   RGNLA+N L+
Sbjct: 64  SGGHINPAITLALLVGNQISLLRAFFYVAAQLVGAIAGAGILYGVAPLNARGNLAVNALN 123

Query: 123 PAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAG 182
              + GQA  VE+ LT Q  LCIFA+ D RR   +GS AL++G S+ LGHL G+Y+TG  
Sbjct: 124 NNTTQGQAMVVELILTFQLALCIFASTDSRRTSPVGSPALSIGLSVTLGHLVGIYFTGCS 183

Query: 183 MNPARSFAPAILTGNFT-NHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGA- 240
           MNPARSF PA++   F+  HWV+WVGPI+G  L ++LY +LLFP   S+SER++++KG  
Sbjct: 184 MNPARSFGPAVVMNRFSPAHWVFWVGPIVGAVLAAILYFYLLFPNSLSLSERVAIIKGTY 243

Query: 241 KPDVS-NGQPEVTGEPVELNTQ 261
           +PD     Q E   + +EL T+
Sbjct: 244 EPDEDWEEQREERKKTMELTTR 265


>gi|86792455 aquaporin 6 [Homo sapiens]
          Length = 282

 Score =  254 bits (650), Expect = 4e-68
 Identities = 127/229 (55%), Positives = 162/229 (70%), Gaps = 2/229 (0%)

Query: 11  RAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVNPA 70
           RA+FAEF AT  YVFFG+GS +RW      VLQ+A+ F L  A  VQ     SGAH NPA
Sbjct: 25  RALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPA 84

Query: 71  VTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQA 130
           VT AFLVGS +SL RA  Y+AAQL+GA  GAA+LY V P  +R  L +N +  +VS GQA
Sbjct: 85  VTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQA 144

Query: 131 TTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMNPARSFA 190
             VE+ LTLQ VLC+FA+ D R+    GS A  +G S+ALGHL G+++TG  MNPARSF 
Sbjct: 145 VAVELLLTLQLVLCVFASTDSRQTS--GSPATMIGISVALGHLIGIHFTGCSMNPARSFG 202

Query: 191 PAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKG 239
           PAI+ G FT HWV+WVGP++G  L SL+Y+F+LFP  K++++RL++L G
Sbjct: 203 PAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTG 251


>gi|4755125 aquaporin 4 isoform b [Homo sapiens]
          Length = 301

 Score =  237 bits (604), Expect = 9e-63
 Identities = 113/255 (44%), Positives = 168/255 (65%), Gaps = 11/255 (4%)

Query: 8   SFWRAIFAEFFATLFYVFFGLGSSLRWA----PGPLHVLQVAMAFGLALATLVQSVGHIS 63
           +FW+A+ AEF A L +V   LGS++ W     P P+ ++ +++ FGL++AT+VQ  GHIS
Sbjct: 11  AFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHIS 70

Query: 64  GAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHP 123
           G H+NPAVT A +   ++S+ ++  Y+AAQ LGA+ GA +LY VTPP+V G L +  +H 
Sbjct: 71  GGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHG 130

Query: 124 AVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGM 183
            ++ G    VE+ +T Q V  IFA+ D +R    GS+ALA+GFS+A+GHLF + YTGA M
Sbjct: 131 NLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASM 190

Query: 184 NPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRL-------KSISERLSV 236
           NPARSF PA++ GN+ NHW+YWVGPIIG  L   LY+++  P +       ++ S+    
Sbjct: 191 NPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQ 250

Query: 237 LKGAKPDVSNGQPEV 251
            KG+  +V + + +V
Sbjct: 251 TKGSYMEVEDNRSQV 265


>gi|4502181 aquaporin 4 isoform a [Homo sapiens]
          Length = 323

 Score =  237 bits (604), Expect = 9e-63
 Identities = 113/255 (44%), Positives = 168/255 (65%), Gaps = 11/255 (4%)

Query: 8   SFWRAIFAEFFATLFYVFFGLGSSLRWA----PGPLHVLQVAMAFGLALATLVQSVGHIS 63
           +FW+A+ AEF A L +V   LGS++ W     P P+ ++ +++ FGL++AT+VQ  GHIS
Sbjct: 33  AFWKAVTAEFLAMLIFVLLSLGSTINWGGTEKPLPVDMVLISLCFGLSIATMVQCFGHIS 92

Query: 64  GAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHP 123
           G H+NPAVT A +   ++S+ ++  Y+AAQ LGA+ GA +LY VTPP+V G L +  +H 
Sbjct: 93  GGHINPAVTVAMVCTRKISIAKSVFYIAAQCLGAIIGAGILYLVTPPSVVGGLGVTMVHG 152

Query: 124 AVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGM 183
            ++ G    VE+ +T Q V  IFA+ D +R    GS+ALA+GFS+A+GHLF + YTGA M
Sbjct: 153 NLTAGHGLLVELIITFQLVFTIFASCDSKRTDVTGSIALAIGFSVAIGHLFAINYTGASM 212

Query: 184 NPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRL-------KSISERLSV 236
           NPARSF PA++ GN+ NHW+YWVGPIIG  L   LY+++  P +       ++ S+    
Sbjct: 213 NPARSFGPAVIMGNWENHWIYWVGPIIGAVLAGGLYEYVFCPDVEFKRRFKEAFSKAAQQ 272

Query: 237 LKGAKPDVSNGQPEV 251
            KG+  +V + + +V
Sbjct: 273 TKGSYMEVEDNRSQV 287


>gi|37694062 aquaporin 1 [Homo sapiens]
          Length = 269

 Score =  233 bits (593), Expect = 2e-61
 Identities = 116/241 (48%), Positives = 157/241 (65%), Gaps = 7/241 (2%)

Query: 3   ELRSASFWRAIFAEFFATLFYVFFGLGSSL--RWAPGPLHV-----LQVAMAFGLALATL 55
           E +   FWRA+ AEF AT  +VF  +GS+L  ++  G         ++V++AFGL++ATL
Sbjct: 4   EFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATL 63

Query: 56  VQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGN 115
            QSVGHISGAH+NPAVT   L+  Q+S+ RA  Y+ AQ +GA+   A+L  +T      +
Sbjct: 64  AQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNS 123

Query: 116 LALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFG 175
           L  N L   V+ GQ   +EI  TLQ VLC+ AT D RR    GS  LA+G S+ALGHL  
Sbjct: 124 LGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLA 183

Query: 176 MYYTGAGMNPARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLS 235
           + YTG G+NPARSF  A++T NF+NHW++WVGP IGG L  L+YDF+L PR   +++R+ 
Sbjct: 184 IDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVK 243

Query: 236 V 236
           V
Sbjct: 244 V 244


>gi|45446752 aquaporin 8 [Homo sapiens]
          Length = 261

 Score =  112 bits (281), Expect = 3e-25
 Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 7/214 (3%)

Query: 9   FWRAIFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLVQSVGHISGAHVN 68
           F +    E   +  ++F G  S +        +LQ A+A GLAL  ++ ++G+ISG H N
Sbjct: 34  FVQPCLVELLGSALFIFIGCLSVIENGTDT-GLLQPALAHGLALGLVIATLGNISGGHFN 92

Query: 69  PAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGN---LALNTLHPAV 125
           PAV+ A ++   ++L+    Y  +QLLG + GAA+  +V+P     N    A  T+    
Sbjct: 93  PAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQG 152

Query: 126 SVGQATTVEIFLTLQFVLCI-FATYDERRNGQLGSVALAVGFSLALGHLFGMYYTGAGMN 184
            V  A   EI LT    L +     +E+  G L     ++GF++ +  L G   +G  MN
Sbjct: 153 QVAGALVAEIILTTLLALAVCMGAINEKTKGPL--APFSIGFAVTVDILAGGPVSGGCMN 210

Query: 185 PARSFAPAILTGNFTNHWVYWVGPIIGGGLGSLL 218
           PAR+F PA++  ++  HW+YW+GP++ G L  LL
Sbjct: 211 PARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLL 244


>gi|4502187 aquaporin 7 [Homo sapiens]
          Length = 342

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 75/247 (30%), Positives = 107/247 (43%), Gaps = 31/247 (12%)

Query: 3   ELRSASFWRAIFAEFFATLFYVFFGLGSSLRWAPGPLH--VLQVAMAFGLALATLVQSVG 60
           E+      R   AEF +T   + FGLGS         +   L V + FG  +   V   G
Sbjct: 27  EILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAG 86

Query: 61  HISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYS-------------- 106
            ISGAH+N AVTFA     ++   +   Y+  Q LG+   AA +YS              
Sbjct: 87  RISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQL 146

Query: 107 -VTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQL-GSVALAV 164
            VT P     +    L   +++ +    E +LT    LC+FA  D+  N  L G+ AL +
Sbjct: 147 MVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVI 206

Query: 165 GFSLA-LGHLFGMYYTGAGMNPARSFAPAILT-------GNFTN----HWVYWVGPIIGG 212
           G  +  +G   GM  TG  +NP+R   P I T         F+N     WV  V P++G 
Sbjct: 207 GILVVIIGVSLGM-NTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGA 265

Query: 213 GLGSLLY 219
            LG ++Y
Sbjct: 266 YLGGIIY 272


>gi|157266307 aquaporin 9 [Homo sapiens]
          Length = 295

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 65/252 (25%), Positives = 110/252 (43%), Gaps = 48/252 (19%)

Query: 7   ASFWRAIFAEFFATLFYVFFGLGSSLR--WAPGPLH-VLQVAMAFGLALATLVQSVGHIS 63
           +S  +   +EF  T   +  G G   +   + G    V+ + + F +A+A  +   G +S
Sbjct: 20  SSLAKETLSEFLGTFILIVLGCGCVAQAILSRGRFGGVITINVGFSMAVAMAIYVAGGVS 79

Query: 64  GAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVR----GNLAL- 118
           G H+NPAV+ A  +  +M   +   Y+ AQ LGA  GAA ++ +    +     G L + 
Sbjct: 80  GGHINPAVSLAMCLFGRMKWFKLPFYVGAQFLGAFVGAATVFGIYYDGLMSFAGGKLLIV 139

Query: 119 ---NTLH-------PAVSVGQATTVEIFLTLQFVLCIFATYDERRNG--------QLGSV 160
               T H       P +S+  A   ++  T+  ++ +FA +D R  G         +G +
Sbjct: 140 GENATAHIFATYPAPYLSLANAFADQVVATMILLIIVFAIFDSRNLGAPRGLEPIAIGLL 199

Query: 161 ALAVGFSLALGHLFGMYYTGAGMNPARSFAPAILT-------------GNFTNHWVYWVG 207
            + +  SL L        +G  MNPAR  +P + T              NF   W+  VG
Sbjct: 200 IIVIASSLGLN-------SGCAMNPARDLSPRLFTALAGWGFEVFRAGNNF--WWIPVVG 250

Query: 208 PIIGGGLGSLLY 219
           P++G  +G L+Y
Sbjct: 251 PLVGAVIGGLIY 262


>gi|4826645 aquaporin 3 [Homo sapiens]
          Length = 292

 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 71/250 (28%), Positives = 104/250 (41%), Gaps = 44/250 (17%)

Query: 11  RAIFAEFFATLFYVFFGLGSSL-----RWAPGPLHVLQVAMAFGLALATLVQSVGHISGA 65
           R   AE   TL  V FG GS       R   G    + +A  F + L  L+   G +SGA
Sbjct: 23  RQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILI--AGQVSGA 80

Query: 66  HVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAV------------- 112
           H+NPAVTFA    ++   ++   Y  AQ LGA  GA +++ +   A+             
Sbjct: 81  HLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGP 140

Query: 113 RGNLALNTLHPAVSVGQATTVEIFL-----TLQFVLCIFATYDERRNG-QLGSVALAVGF 166
            G   +   +P+   G    +  F      T   ++C+ A  D   N    G  A  VG 
Sbjct: 141 NGTAGIFATYPS---GHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGL 197

Query: 167 -SLALGHLFGMYYTGAGMNPARSFAPAILT-------GNFT--NHWVYW---VGPIIGGG 213
             L +G   G + +G  +NPAR F P + T         FT   HW +W   V P++G  
Sbjct: 198 VVLVIGTSMG-FNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHW-WWVPIVSPLLGSI 255

Query: 214 LGSLLYDFLL 223
            G  +Y  ++
Sbjct: 256 AGVFVYQLMI 265


>gi|22538420 aquaporin 10 [Homo sapiens]
          Length = 301

 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 53/207 (25%), Positives = 85/207 (41%), Gaps = 31/207 (14%)

Query: 46  MAFGLALATLVQSVGHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLY 105
           +A  LA+   +   G++SGAH+NPA + A  +  ++  ++   Y+  QLL A   +   Y
Sbjct: 60  LAGSLAVTIAIYVGGNVSGAHLNPAFSLAMCIVGRLPWVKLPIYILVQLLSAFCASGATY 119

Query: 106 ---------------SVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYD 150
                          +VT P    ++      P +S+      ++  T   ++ + A  D
Sbjct: 120 VLYHDALQNYTGGNLTVTGPKETASIFATYPAPYLSLNNGFLDQVLGTGMLIVGLLAILD 179

Query: 151 ERRNG-QLGSVALAVG-FSLALGHLFGMYYTGAGMNPARSFAPAILT------------G 196
            R  G   G   + VG   LALG   G    G  +NPAR   P + T            G
Sbjct: 180 RRNKGVPAGLEPVVVGMLILALGLSMGA-NCGIPLNPARDLGPRLFTYVAGWGPEVFSAG 238

Query: 197 NFTNHWVYWVGPIIGGGLGSLLYDFLL 223
           N    WV  V P++G  +G+  Y  L+
Sbjct: 239 NGW-WWVPVVAPLVGATVGTATYQLLV 264


>gi|4507047 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 1 [Homo sapiens]
          Length = 629

 Score = 30.4 bits (67), Expect = 1.6
 Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 1/64 (1%)

Query: 44  VAMAFGLALATLVQSV-GHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAA 102
           VA+  G  L   V  + G ++  +  PA+  +FL+ +  S+L   CY          G+A
Sbjct: 38  VALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSA 97

Query: 103 VLYS 106
            LYS
Sbjct: 98  YLYS 101


>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
          Length = 764

 Score = 30.0 bits (66), Expect = 2.1
 Identities = 13/44 (29%), Positives = 23/44 (52%)

Query: 13  IFAEFFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLV 56
           ++A FF  + Y+FFG    +   P P+  + V +A   A++  V
Sbjct: 106 LYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAV 149


>gi|114326550 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 3 [Homo sapiens]
          Length = 619

 Score = 29.6 bits (65), Expect = 2.8
 Identities = 19/64 (29%), Positives = 29/64 (45%), Gaps = 1/64 (1%)

Query: 44  VAMAFGLALATLVQSV-GHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAA 102
           VA+  G  L   V  + G ++     P++   FLV +  S+L   CY         +G+A
Sbjct: 38  VALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSA 97

Query: 103 VLYS 106
            LYS
Sbjct: 98  YLYS 101


>gi|114326544 solute carrier family 7 (cationic amino acid
           transporter, y+ system), member 3 [Homo sapiens]
          Length = 619

 Score = 29.6 bits (65), Expect = 2.8
 Identities = 19/64 (29%), Positives = 29/64 (45%), Gaps = 1/64 (1%)

Query: 44  VAMAFGLALATLVQSV-GHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAA 102
           VA+  G  L   V  + G ++     P++   FLV +  S+L   CY         +G+A
Sbjct: 38  VALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSA 97

Query: 103 VLYS 106
            LYS
Sbjct: 98  YLYS 101


>gi|40538880 aquaporin 12A [Homo sapiens]
          Length = 295

 Score = 29.6 bits (65), Expect = 2.8
 Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 14/168 (8%)

Query: 62  ISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVL-----YSVTPPAVRGNL 116
           + GA  NP V+    + ++ SL      +AAQ LG  A   ++     + ++   +  +L
Sbjct: 75  LDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGLGMQAACTLMRLCWAWELSDLHLLQSL 134

Query: 117 ALNTLHPAV--SVGQATTVEIFLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLF 174
              +   A+  SV     VE         C   T    R+        AV   + +    
Sbjct: 135 MAQSCSSALRTSVPHGALVE----AACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYT 190

Query: 175 GMYYTGAGMNPARSFAPAILTGNFT---NHWVYWVGPIIGGGLGSLLY 219
              +T A  NPA + +        T      VYW+GP+ G  L  LL+
Sbjct: 191 AGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLH 238


>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
           sapiens]
          Length = 697

 Score = 28.9 bits (63), Expect = 4.8
 Identities = 35/149 (23%), Positives = 57/149 (38%), Gaps = 30/149 (20%)

Query: 44  VAMAFGLALATLVQSV-GHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAA 102
           +A+  G  L   V  + G ++ A   P++  +FL+ +  S++   CY          G+A
Sbjct: 80  IALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSA 139

Query: 103 VLYSVTPPA-----VRG-NLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQ 156
            LY+          + G NL L+ +    SV +A +               T+DE  + Q
Sbjct: 140 YLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWS--------------GTFDELLSKQ 185

Query: 157 LGSVALAVGFSLALGHLFGMYYTGAGMNP 185
           +G           L   F M YTG    P
Sbjct: 186 IGQF---------LRTYFRMNYTGLAEYP 205


>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
           sapiens]
          Length = 658

 Score = 28.9 bits (63), Expect = 4.8
 Identities = 35/149 (23%), Positives = 57/149 (38%), Gaps = 30/149 (20%)

Query: 44  VAMAFGLALATLVQSV-GHISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAA 102
           +A+  G  L   V  + G ++ A   P++  +FL+ +  S++   CY          G+A
Sbjct: 40  IALGVGSTLGAGVYVLAGEVAKADSGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSA 99

Query: 103 VLYSVTPPA-----VRG-NLALNTLHPAVSVGQATTVEIFLTLQFVLCIFATYDERRNGQ 156
            LY+          + G NL L+ +    SV +A +               T+DE  + Q
Sbjct: 100 YLYTYVTVGELWAFITGWNLILSYVIGTSSVARAWS--------------GTFDELLSKQ 145

Query: 157 LGSVALAVGFSLALGHLFGMYYTGAGMNP 185
           +G           L   F M YTG    P
Sbjct: 146 IGQF---------LRTYFRMNYTGLAEYP 165


>gi|6005794 PRA1 domain family, member 2 [Homo sapiens]
          Length = 178

 Score = 28.9 bits (63), Expect = 4.8
 Identities = 14/40 (35%), Positives = 22/40 (55%)

Query: 17 FFATLFYVFFGLGSSLRWAPGPLHVLQVAMAFGLALATLV 56
          ++ T + + FG+G +L     PLH L  A+   +AL  LV
Sbjct: 43 YYQTNYLLCFGIGLALAGYVRPLHTLLSALVVAVALGVLV 82


>gi|62526026 cutA divalent cation tolerance homolog isoform 3 [Homo
           sapiens]
          Length = 179

 Score = 28.9 bits (63), Expect = 4.8
 Identities = 14/47 (29%), Positives = 24/47 (51%)

Query: 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEP 255
           ++ GG+ SLL  F+  P L  ++ RL +L      +++G P     P
Sbjct: 9   VLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTMASGSPPTQPSP 55


>gi|166235140 seizure related 6 homolog (mouse)-like 2 isoform 4
           [Homo sapiens]
          Length = 809

 Score = 28.5 bits (62), Expect = 6.2
 Identities = 34/130 (26%), Positives = 53/130 (40%), Gaps = 29/130 (22%)

Query: 84  LRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIF---LTLQ 140
           LR FCY   +L+G          VT   V G       HP+    Q    ++    L   
Sbjct: 681 LRFFCYEGFELIG---------EVTITCVPG-------HPSQWTSQPPLCKVAYEELLDN 724

Query: 141 FVLCIFATYDERRNGQLGSVALAV----GFSLALGHLFGMYYTGA------GMNPARSFA 190
             L +  T D  R  + G++ALA+    G  + LG    +YYT        G + + S++
Sbjct: 725 RKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYS 784

Query: 191 PAILTGNFTN 200
           P  +  +F+N
Sbjct: 785 PITVESDFSN 794


>gi|6912612 seizure related 6 homolog (mouse)-like 2 isoform 1 [Homo
           sapiens]
          Length = 853

 Score = 28.5 bits (62), Expect = 6.2
 Identities = 34/130 (26%), Positives = 53/130 (40%), Gaps = 29/130 (22%)

Query: 84  LRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIF---LTLQ 140
           LR FCY   +L+G          VT   V G       HP+    Q    ++    L   
Sbjct: 725 LRFFCYEGFELIG---------EVTITCVPG-------HPSQWTSQPPLCKVAYEELLDN 768

Query: 141 FVLCIFATYDERRNGQLGSVALAV----GFSLALGHLFGMYYTGA------GMNPARSFA 190
             L +  T D  R  + G++ALA+    G  + LG    +YYT        G + + S++
Sbjct: 769 RKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYS 828

Query: 191 PAILTGNFTN 200
           P  +  +F+N
Sbjct: 829 PITVESDFSN 838


>gi|166235138 seizure related 6 homolog (mouse)-like 2 isoform 3
           [Homo sapiens]
          Length = 840

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 38/128 (29%)

Query: 84  LRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVL 143
           LR FCY   +L+G          VT   V G       HP+             T Q  L
Sbjct: 725 LRFFCYEGFELIG---------EVTITCVPG-------HPSQ-----------WTSQPPL 757

Query: 144 C-IFATYDERRNGQLGSVALAV----GFSLALGHLFGMYYTGA------GMNPARSFAPA 192
           C +  T D  R  + G++ALA+    G  + LG    +YYT        G + + S++P 
Sbjct: 758 CKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI 817

Query: 193 ILTGNFTN 200
            +  +F+N
Sbjct: 818 TVESDFSN 825


>gi|166235136 seizure related 6 homolog (mouse)-like 2 isoform 2
           [Homo sapiens]
          Length = 910

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 35/128 (27%), Positives = 52/128 (40%), Gaps = 38/128 (29%)

Query: 84  LRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTLHPAVSVGQATTVEIFLTLQFVL 143
           LR FCY   +L+G          VT   V G       HP+             T Q  L
Sbjct: 795 LRFFCYEGFELIG---------EVTITCVPG-------HPSQ-----------WTSQPPL 827

Query: 144 C-IFATYDERRNGQLGSVALAV----GFSLALGHLFGMYYTGA------GMNPARSFAPA 192
           C +  T D  R  + G++ALA+    G  + LG    +YYT        G + + S++P 
Sbjct: 828 CKVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPI 887

Query: 193 ILTGNFTN 200
            +  +F+N
Sbjct: 888 TVESDFSN 895


>gi|7108340 deoxyhypusine synthase isoform c [Homo sapiens]
          Length = 313

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 20/65 (30%), Positives = 32/65 (49%), Gaps = 6/65 (9%)

Query: 200 NHWVYWVGPIIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPD--VSNGQPEVTGEPVE 257
           NH   +   +  G LG    D + F   K+    L +++GA+PD  VS G+  V  +PV+
Sbjct: 227 NHIPVFSPALTDGSLG----DMIFFHSYKNPGLVLDIVEGARPDEAVSWGKIRVDAQPVK 282

Query: 258 LNTQA 262
           +   A
Sbjct: 283 VYADA 287


>gi|156447037 aquaporin 12B [Homo sapiens]
          Length = 307

 Score = 28.1 bits (61), Expect = 8.2
 Identities = 40/165 (24%), Positives = 59/165 (35%), Gaps = 8/165 (4%)

Query: 62  ISGAHVNPAVTFAFLVGSQMSLLRAFCYMAAQLLGAVAGAAVLYSVTPPAVRGNLALNTL 121
           + GA  NP V+    + ++ SL      +AAQ LG  A A  L  +       +L L   
Sbjct: 87  LDGASANPTVSLQEFLMAEESLPGTLLKLAAQGLGMQA-ACTLTRLCWAWELSDLHLLQS 145

Query: 122 HPAVSVGQATTVEI----FLTLQFVLCIFATYDERRNGQLGSVALAVGFSLALGHLFGMY 177
             A S   A    +     +      C   T    R+        AV   + +       
Sbjct: 146 LMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGP 205

Query: 178 YTGAGMNPARSFAPAILTGNFT---NHWVYWVGPIIGGGLGSLLY 219
           +T A  NPA + +        T      VYW+GP+ G  L  LL+
Sbjct: 206 FTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPLTGMVLAVLLH 250


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.139    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,217,294
Number of Sequences: 37866
Number of extensions: 373508
Number of successful extensions: 1045
Number of sequences better than 10.0: 27
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1004
Number of HSP's gapped (non-prelim): 28
length of query: 263
length of database: 18,247,518
effective HSP length: 100
effective length of query: 163
effective length of database: 14,460,918
effective search space: 2357129634
effective search space used: 2357129634
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.