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Search of human proteins with 6912312
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912312 claudin 12 [Homo sapiens]
(244 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912312 claudin 12 [Homo sapiens] 503 e-143
gi|40788011 claudin 8 [Homo sapiens] 54 2e-07
gi|183979973 claudin 19 isoform a [Homo sapiens] 52 4e-07
gi|183979975 claudin 19 isoform b [Homo sapiens] 52 4e-07
gi|6912316 claudin 17 [Homo sapiens] 49 4e-06
gi|47716519 claudin 20 [Homo sapiens] 46 3e-05
gi|4502875 claudin 3 [Homo sapiens] 45 6e-05
gi|4502877 claudin 4 [Homo sapiens] 44 1e-04
gi|9966781 claudin 2 [Homo sapiens] 44 1e-04
gi|5729970 claudin 16 [Homo sapiens] 43 3e-04
gi|10863887 claudin 1 [Homo sapiens] 42 4e-04
gi|225703142 claudin 14 [Homo sapiens] 42 6e-04
gi|21536294 claudin 14 [Homo sapiens] 42 6e-04
gi|225703138 claudin 14 [Homo sapiens] 42 6e-04
gi|6912314 claudin 14 [Homo sapiens] 42 6e-04
gi|225703140 claudin 14 [Homo sapiens] 42 6e-04
gi|11141861 claudin 9 [Homo sapiens] 40 0.001
gi|7705961 claudin 18 isoform 1 [Homo sapiens] 33 0.17
gi|169167239 PREDICTED: claudin-24-like [Homo sapiens] 30 1.5
gi|169166931 PREDICTED: claudin-24-like [Homo sapiens] 30 1.5
gi|33598916 claudin 10 isoform a [Homo sapiens] 30 1.9
gi|46048143 olfactory receptor, family 1, subfamily N, member 1 ... 30 2.5
gi|169166402 PREDICTED: claudin-24-like [Homo sapiens] 28 7.3
gi|4507397 transcription factor 2 [Homo sapiens] 28 7.3
gi|50897282 olfactory receptor, family 8, subfamily D, member 1 ... 28 7.3
gi|157412255 praja 2, RING-H2 motif containing [Homo sapiens] 28 9.5
gi|210147462 von Willebrand factor A domain containing 5B1 [Homo... 28 9.5
gi|66932941 XC chemokine receptor 1 [Homo sapiens] 28 9.5
gi|4885339 XC chemokine receptor 1 [Homo sapiens] 28 9.5
>gi|6912312 claudin 12 [Homo sapiens]
Length = 244
Score = 503 bits (1295), Expect = e-143
Identities = 244/244 (100%), Positives = 244/244 (100%)
Query: 1 MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCAR 60
MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCAR
Sbjct: 1 MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCAR 60
Query: 61 YDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNI 120
YDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNI
Sbjct: 61 YDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNI 120
Query: 121 KLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIA 180
KLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIA
Sbjct: 121 KLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIA 180
Query: 181 SAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVV 240
SAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVV
Sbjct: 181 SAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVV 240
Query: 241 SHTT 244
SHTT
Sbjct: 241 SHTT 244
>gi|40788011 claudin 8 [Homo sapiens]
Length = 225
Score = 53.5 bits (127), Expect = 2e-07
Identities = 57/227 (25%), Positives = 90/227 (39%), Gaps = 34/227 (14%)
Query: 7 HAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYT----GLWVKCARYD 62
HA + G + G A T++P WR I E N+ V+ GLW+ C R
Sbjct: 4 HALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFI-----ENNIVVFENFWEGLWMNCVRQA 58
Query: 63 G-SSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIK 121
C +YD+ S D R L A + +A ++ ++GM T +K
Sbjct: 59 NIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAF---MMAILGMKCTRCTGDNEKVK 115
Query: 122 LAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYN--IHLNKKFEPVFSFDY 173
A L AG++F + G V L P WV FYN +++ +K E
Sbjct: 116 --------AHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRE----LGE 163
Query: 174 AVYVTIASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTY 220
A+Y+ +A L + + +C C S + + SH + +Y
Sbjct: 164 ALYLGWTTALVLIVGGALFCCVFC-CNEKSSSYRYSIPSHRTTQKSY 209
>gi|183979973 claudin 19 isoform a [Homo sapiens]
Length = 224
Score = 52.4 bits (124), Expect = 4e-07
Identities = 59/216 (27%), Positives = 95/216 (43%), Gaps = 44/216 (20%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKL-----RLITFNRNEKNLTVYTGLWVKCA-RYDGS 64
+L + + G+ A T LP W++ +IT + +Y GLW+ CA + G
Sbjct: 8 LLGYFLALGGWVGIIASTALPQWKQSSYAGDAIIT------AVGLYEGLWMSCASQSTGQ 61
Query: 65 SDCLMYDTTWYSSVDQLD--LRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKL 122
C +YD S+ LD ++ + + +++L+ A++L ++GM T S P +
Sbjct: 62 VQCKLYD-----SLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNP---I 113
Query: 123 AKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPV------FSFDYAVY 176
AK V AG G LF LAG +L+ W + + + F P + F A++
Sbjct: 114 AKGRVAIAG-----GALFILAGLCTLTAVSW--YATLVTQEFFNPSTPVNARYEFGPALF 166
Query: 177 VTIASAGGLFMTSLILFIWYCTC------KSLPSPF 206
V ASAG + L CTC S P P+
Sbjct: 167 VGWASAGLAVLGGSFL---CCTCPEPERPNSSPQPY 199
>gi|183979975 claudin 19 isoform b [Homo sapiens]
Length = 211
Score = 52.4 bits (124), Expect = 4e-07
Identities = 59/216 (27%), Positives = 95/216 (43%), Gaps = 44/216 (20%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKL-----RLITFNRNEKNLTVYTGLWVKCA-RYDGS 64
+L + + G+ A T LP W++ +IT + +Y GLW+ CA + G
Sbjct: 8 LLGYFLALGGWVGIIASTALPQWKQSSYAGDAIIT------AVGLYEGLWMSCASQSTGQ 61
Query: 65 SDCLMYDTTWYSSVDQLD--LRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKL 122
C +YD S+ LD ++ + + +++L+ A++L ++GM T S P +
Sbjct: 62 VQCKLYD-----SLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNP---I 113
Query: 123 AKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPV------FSFDYAVY 176
AK V AG G LF LAG +L+ W + + + F P + F A++
Sbjct: 114 AKGRVAIAG-----GALFILAGLCTLTAVSW--YATLVTQEFFNPSTPVNARYEFGPALF 166
Query: 177 VTIASAGGLFMTSLILFIWYCTC------KSLPSPF 206
V ASAG + L CTC S P P+
Sbjct: 167 VGWASAGLAVLGGSFL---CCTCPEPERPNSSPQPY 199
>gi|6912316 claudin 17 [Homo sapiens]
Length = 224
Score = 48.9 bits (115), Expect = 4e-06
Identities = 56/213 (26%), Positives = 86/213 (40%), Gaps = 34/213 (15%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWR-----KLRLITFNRNEKNLTVYTGLWVKCARYDGSS 65
+ + G + G A TLLP WR +I F R ++ GLW+ C R
Sbjct: 8 IAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFER------LWEGLWMNCIR----Q 57
Query: 66 DCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKC 125
+ +YSS+ L L+ A L + +L+ LIG+C + + AK
Sbjct: 58 ARVRLQCKFYSSLLALP-PALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKA 116
Query: 126 LVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYN--IHLNKKFEPVFSFDYAVYV 177
+ +G+LF L G L P W FYN IH+ +K E A+++
Sbjct: 117 YLLG-----TSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRE----LGAALFL 167
Query: 178 TIASAGGLFMTSLILFIWYCTCKSLPSPFWQPL 210
ASA LF+ +L +C C + P+
Sbjct: 168 GWASAAVLFIGGGLL-CGFCCCNRKKQGYRYPV 199
>gi|47716519 claudin 20 [Homo sapiens]
Length = 219
Score = 45.8 bits (107), Expect = 3e-05
Identities = 44/196 (22%), Positives = 81/196 (41%), Gaps = 28/196 (14%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDCLMY 70
+L+F+ ++ V+G+ TLLPNW K+ + + + GLW+ DC Y
Sbjct: 8 LLAFILALSGVSGVLTATLLPNW-KVNVDVDSNIITAIVQLHGLWM---------DCTWY 57
Query: 71 DTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSA 130
T +S + + L + + + A +L +G+C + + +L +
Sbjct: 58 STGMFSCALKHSILSLPIHVQAARATMVLACVLSALGICTSTV--GMKCTRLGGDRETKS 115
Query: 131 GCHLVAGLLFFLAGTVSLSPSIW--------VIFYNIHLNKKFEPVFSFDYAVYVTIASA 182
G+ F AG SL ++W + + + K EP A+Y+ SA
Sbjct: 116 HASFAGGVCFMSAGISSLISTVWYTKEIIANFLDLTVPESNKHEP----GGAIYIGFISA 171
Query: 183 GGLFMTSLILFIWYCT 198
LF++ +I +CT
Sbjct: 172 MLLFISGMI----FCT 183
>gi|4502875 claudin 3 [Homo sapiens]
Length = 220
Score = 45.1 bits (105), Expect = 6e-05
Identities = 35/126 (27%), Positives = 58/126 (46%), Gaps = 16/126 (12%)
Query: 30 LPNWRKLRLITFNRNEKNLTVYTGLWVKCA-RYDGSSDCLMYDTTWYSSVDQLDLRVLQF 88
LP WR I N ++ GLW+ C + G C +YD+ ++ Q DL+ +
Sbjct: 26 LPMWRVSAFIGSNIITSQ-NIWEGLWMNCVVQSTGQMQCKVYDSLL--ALPQ-DLQAARA 81
Query: 89 ALPLSMLIAMGALLLCLIG-MCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVS 147
+ +++L+A LL+ L+G C + K+ +VAG+LF LA ++
Sbjct: 82 LIVVAILLAAFGLLVALVGAQCTNCVQDDTAKAKIT----------IVAGVLFLLAALLT 131
Query: 148 LSPSIW 153
L P W
Sbjct: 132 LVPVSW 137
>gi|4502877 claudin 4 [Homo sapiens]
Length = 209
Score = 44.3 bits (103), Expect = 1e-04
Identities = 55/213 (25%), Positives = 87/213 (40%), Gaps = 44/213 (20%)
Query: 30 LPNWRKLRLITFNRNEKNLTVYTGLWVKCA-RYDGSSDCLMYDTTWYSSVDQLDLRVLQF 88
LP WR I N T++ GLW+ C + G C +YD+ ++ Q DL+ +
Sbjct: 27 LPMWRVTAFIGSNIVTSQ-TIWEGLWMNCVVQSTGQMQCKVYDSLL--ALPQ-DLQAARA 82
Query: 89 ALPLSMLIA-MGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGTVS 147
+ +S+++A +G LL + G C K +VAG++F LAG +
Sbjct: 83 LVIISIIVAALGVLLSVVGGKCTNCLEDESAKAKTM----------IVAGVVFLLAGLMV 132
Query: 148 LSPSIWVI------FYN--IHLNKKFEPVFSFDYAVYVTIASAGGLFMTSLILFIWYCTC 199
+ P W FYN + +K E ++YV A++G L + +L C C
Sbjct: 133 IVPVSWTAHNIIQDFYNPLVASGQKRE----MGASLYVGWAASGLLLLGGGLL---CCNC 185
Query: 200 KSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSA 232
P + YS YSA +A
Sbjct: 186 P-------------PRTDKPYSAKYSAARSAAA 205
>gi|9966781 claudin 2 [Homo sapiens]
Length = 230
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/222 (22%), Positives = 93/222 (41%), Gaps = 27/222 (12%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYD-GSSDCLM 69
++ ++ G+ + G LLP+W+ + + + GLW++CA + G + C +
Sbjct: 8 LVGYILGLLGLLGTLVAMLLPSWKTSSYVGAS-IVTAVGFSKGLWMECATHSTGITQCDI 66
Query: 70 YDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNS 129
Y T D++ Q + S I+ A ++ ++GM T F AK V
Sbjct: 67 YSTLLGLPA---DIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQE----SRAKDRVAV 119
Query: 130 AGCHLVAGLLFFLAGTVSLSPSIWVIFYNIH--LNKKFEPV------FSFDYAVYVTIAS 181
AG G+ F L G + P W N+H L + P+ F A+Y+ I S
Sbjct: 120 AG-----GVFFILGGLLGFIPVAW----NLHGILRDFYSPLVPDSMKFEIGEALYLGIIS 170
Query: 182 AGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQP 223
+ + +IL + C+ + S ++ + P + + +P
Sbjct: 171 SLFSLIAGIIL-CFSCSSQRNRSNYYDAYQAQPLATRSSPRP 211
>gi|5729970 claudin 16 [Homo sapiens]
Length = 305
Score = 42.7 bits (99), Expect = 3e-04
Identities = 46/199 (23%), Positives = 82/199 (41%), Gaps = 29/199 (14%)
Query: 9 ATVLSFLCGIASVAGLFAGTLL--PNWRKLRLITFNRNEKNLTVYTGLWVKCAR--YDGS 64
AT+ L IA F+ L W ++ + + + T GLW +C +DG
Sbjct: 69 ATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWECVTNAFDGI 128
Query: 65 SDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAK 124
C YD+ + L L V + + + ++A L L+G+ F P IK+
Sbjct: 129 RTCDEYDSIL--AEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEPYIKVRI 186
Query: 125 CLVNSAGCHLVAGLLFFLAGTVSLSPSIW-----------VIFYNIHLNKKFEPVFSFDY 173
C V AG +AGT + S+W ++ +NI L +++ F +
Sbjct: 187 CFV--------AGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYK----FGW 234
Query: 174 AVYVTIASAGGLFMTSLIL 192
+ ++ +A + G F+ +L
Sbjct: 235 SCWLGMAGSLGCFLAGAVL 253
>gi|10863887 claudin 1 [Homo sapiens]
Length = 211
Score = 42.4 bits (98), Expect = 4e-04
Identities = 47/210 (22%), Positives = 84/210 (40%), Gaps = 36/210 (17%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKC-ARYDGSSDCLM 69
+L F+ G T LP WR N +Y GLW+ C ++ G C +
Sbjct: 8 LLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQ-AMYEGLWMSCVSQSTGQIQCKV 66
Query: 70 YDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCL--- 126
+D+ S L+ + + + +L+ + A+ + +GM K KCL
Sbjct: 67 FDSLLNLS---STLQATRALMVVGILLGVIAIFVATVGM------------KCMKCLEDD 111
Query: 127 -VNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPV------FSFDYAVYVTI 179
V ++ G +F LAG L + W + N + + ++P+ + F A++
Sbjct: 112 EVQKMRMAVIGGAIFLLAGLAILVATAW--YGNRIVQEFYDPMTPVNARYEFGQALFTGW 169
Query: 180 ASAGGLFMTSLILFIWYCTC----KSLPSP 205
A+A + +L C+C S P+P
Sbjct: 170 AAASLCLLGGALL---CCSCPRKTTSYPTP 196
>gi|225703142 claudin 14 [Homo sapiens]
Length = 239
Score = 41.6 bits (96), Expect = 6e-04
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 30/220 (13%)
Query: 8 AATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDC 67
A +L FL + G T+LP+WR+ + N ++ GLW++C +
Sbjct: 5 AVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTA-VSYLKGLWMECVWHSTG--- 60
Query: 68 LMYDTTWYSSVDQL--DLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKC 125
+Y Y S+ L DL+ + + +S L++ A +IGM T + AK
Sbjct: 61 -IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCT---------RCAKG 110
Query: 126 LVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYNIHLNKKFEPVFSFDYAVYVTI 179
++ G LF LAG + + W FYN L + F A+Y+
Sbjct: 111 TPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMK--FEIGQALYL-- 166
Query: 180 ASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHT 219
G +SL L C S Y PP T
Sbjct: 167 ----GFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATT 202
>gi|21536294 claudin 14 [Homo sapiens]
Length = 239
Score = 41.6 bits (96), Expect = 6e-04
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 30/220 (13%)
Query: 8 AATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDC 67
A +L FL + G T+LP+WR+ + N ++ GLW++C +
Sbjct: 5 AVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTA-VSYLKGLWMECVWHSTG--- 60
Query: 68 LMYDTTWYSSVDQL--DLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKC 125
+Y Y S+ L DL+ + + +S L++ A +IGM T + AK
Sbjct: 61 -IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCT---------RCAKG 110
Query: 126 LVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYNIHLNKKFEPVFSFDYAVYVTI 179
++ G LF LAG + + W FYN L + F A+Y+
Sbjct: 111 TPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMK--FEIGQALYL-- 166
Query: 180 ASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHT 219
G +SL L C S Y PP T
Sbjct: 167 ----GFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATT 202
>gi|225703138 claudin 14 [Homo sapiens]
Length = 239
Score = 41.6 bits (96), Expect = 6e-04
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 30/220 (13%)
Query: 8 AATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDC 67
A +L FL + G T+LP+WR+ + N ++ GLW++C +
Sbjct: 5 AVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTA-VSYLKGLWMECVWHSTG--- 60
Query: 68 LMYDTTWYSSVDQL--DLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKC 125
+Y Y S+ L DL+ + + +S L++ A +IGM T + AK
Sbjct: 61 -IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCT---------RCAKG 110
Query: 126 LVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYNIHLNKKFEPVFSFDYAVYVTI 179
++ G LF LAG + + W FYN L + F A+Y+
Sbjct: 111 TPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMK--FEIGQALYL-- 166
Query: 180 ASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHT 219
G +SL L C S Y PP T
Sbjct: 167 ----GFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATT 202
>gi|6912314 claudin 14 [Homo sapiens]
Length = 239
Score = 41.6 bits (96), Expect = 6e-04
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 30/220 (13%)
Query: 8 AATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDC 67
A +L FL + G T+LP+WR+ + N ++ GLW++C +
Sbjct: 5 AVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTA-VSYLKGLWMECVWHSTG--- 60
Query: 68 LMYDTTWYSSVDQL--DLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKC 125
+Y Y S+ L DL+ + + +S L++ A +IGM T + AK
Sbjct: 61 -IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCT---------RCAKG 110
Query: 126 LVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYNIHLNKKFEPVFSFDYAVYVTI 179
++ G LF LAG + + W FYN L + F A+Y+
Sbjct: 111 TPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMK--FEIGQALYL-- 166
Query: 180 ASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHT 219
G +SL L C S Y PP T
Sbjct: 167 ----GFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATT 202
>gi|225703140 claudin 14 [Homo sapiens]
Length = 239
Score = 41.6 bits (96), Expect = 6e-04
Identities = 54/220 (24%), Positives = 83/220 (37%), Gaps = 30/220 (13%)
Query: 8 AATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARYDGSSDC 67
A +L FL + G T+LP+WR+ + N ++ GLW++C +
Sbjct: 5 AVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTA-VSYLKGLWMECVWHSTG--- 60
Query: 68 LMYDTTWYSSVDQL--DLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKC 125
+Y Y S+ L DL+ + + +S L++ A +IGM T + AK
Sbjct: 61 -IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCT---------RCAKG 110
Query: 126 LVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYNIHLNKKFEPVFSFDYAVYVTI 179
++ G LF LAG + + W FYN L + F A+Y+
Sbjct: 111 TPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMK--FEIGQALYL-- 166
Query: 180 ASAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHT 219
G +SL L C S Y PP T
Sbjct: 167 ----GFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATT 202
>gi|11141861 claudin 9 [Homo sapiens]
Length = 217
Score = 40.4 bits (93), Expect = 0.001
Identities = 45/163 (27%), Positives = 70/163 (42%), Gaps = 27/163 (16%)
Query: 8 AATVLSFLCGIASVAGLFAGTL----LPNWRKLRLITFNRNEKNLTVYTGLWVKCA-RYD 62
A+T L L +V G + GTL LP W+ I N V+ GLW+ C +
Sbjct: 2 ASTGLELLGMTLAVLG-WLGTLVSCALPLWKVTAFIG-NSIVVAQVVWEGLWMSCVVQST 59
Query: 63 GSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIG-MCNTAFRSSVPNIK 121
G C +YD+ ++ Q DL+ + +++L+A+ LL+ + G C T +
Sbjct: 60 GQMQCKVYDSLL--ALPQ-DLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKAR 116
Query: 122 LAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVI------FYN 158
+ L AG++ LAG + L P W FYN
Sbjct: 117 IV----------LTAGVILLLAGILVLIPVCWTAHAIIQDFYN 149
>gi|7705961 claudin 18 isoform 1 [Homo sapiens]
Length = 261
Score = 33.5 bits (75), Expect = 0.17
Identities = 34/140 (24%), Positives = 61/140 (43%), Gaps = 14/140 (10%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCARY-DGSSDCLM 69
V++FL I +AG A T + W L ++ ++ Y GLW C R G ++C
Sbjct: 8 VVAFLLSILGLAGCIAATGMDMWSTQDL--YDNPVTSVFQYEGLWRSCVRQSSGFTECRP 65
Query: 70 YDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNS 129
Y T L L + A+ M++ ++L IG+ + F I +
Sbjct: 66 YFTI-------LGLPAMLQAVRALMIV---GIVLGAIGLLVSIFALKCIRIGSMEDSA-K 114
Query: 130 AGCHLVAGLLFFLAGTVSLS 149
A L +G++F ++G +++
Sbjct: 115 ANMTLTSGIMFIVSGLCAIA 134
>gi|169167239 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 30.4 bits (67), Expect = 1.5
Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 22/146 (15%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNE-KNLTVYTGLWVKCA-RYDGSSDCL 68
+LSFL I S+ T LP+W+ L L + NE +N T+ GLW C + + C
Sbjct: 15 LLSFLGWILSIIT----TYLPHWKNLNL---DLNEMENWTM--GLWQTCVIQEEVGMQCK 65
Query: 69 MYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVN 128
+D+ + R+L F + +G L L + G R L + L+
Sbjct: 66 DFDSFLALPAELRVSRILMF-----LSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLL- 119
Query: 129 SAGCHLVAGLLFFLAGTVSLSPSIWV 154
++ G+L + +G +L P WV
Sbjct: 120 -----ILGGILSWASGITALVPVSWV 140
>gi|169166931 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 30.4 bits (67), Expect = 1.5
Identities = 39/146 (26%), Positives = 63/146 (43%), Gaps = 22/146 (15%)
Query: 11 VLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNE-KNLTVYTGLWVKCA-RYDGSSDCL 68
+LSFL I S+ T LP+W+ L L + NE +N T+ GLW C + + C
Sbjct: 15 LLSFLGWILSIIT----TYLPHWKNLNL---DLNEMENWTM--GLWQTCVIQEEVGMQCK 65
Query: 69 MYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVN 128
+D+ + R+L F + +G L L + G R L + L+
Sbjct: 66 DFDSFLALPAELRVSRILMF-----LSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLL- 119
Query: 129 SAGCHLVAGLLFFLAGTVSLSPSIWV 154
++ G+L + +G +L P WV
Sbjct: 120 -----ILGGILSWASGITALVPVSWV 140
>gi|33598916 claudin 10 isoform a [Homo sapiens]
Length = 226
Score = 30.0 bits (66), Expect = 1.9
Identities = 41/166 (24%), Positives = 66/166 (39%), Gaps = 25/166 (15%)
Query: 9 ATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLT---VYTGLWVKCA-RYDGS 64
A + + + G+ L A T W+ R +T VY GLW+ CA GS
Sbjct: 4 AQIWALVSGVGGFGALVAATTSNEWK-----VTTRASSVITATWVYQGLWMNCAGNALGS 58
Query: 65 SDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGM-CNTAFRSSVPNIKLA 123
C + T + + R L A ++ + + L GM C S K+A
Sbjct: 59 FHCRPHFTIFKVAGYIQACRGLMIA---AVSLGFFGSIFALFGMKCTKVGGSDKAKAKIA 115
Query: 124 KCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVF 169
CL AG++F L+G S++ ++ N + F+P+F
Sbjct: 116 -CL---------AGIVFILSGLCSMTGC--SLYANKITTEFFDPLF 149
>gi|46048143 olfactory receptor, family 1, subfamily N, member 1
[Homo sapiens]
Length = 311
Score = 29.6 bits (65), Expect = 2.5
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 8/105 (7%)
Query: 60 RYDGSSDCLMYDTTWYSSVDQLDLR---VLQFALPLSMLIAMGALLLCLIGMCNTAFRSS 116
RY L Y T V L L VL + L+ M L C+ G F
Sbjct: 120 RYVAICHPLCYSTVMRPQVCALMLALCWVLTNIVALTHTFLMARLSFCVTGEIAHFFCDI 179
Query: 117 VPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHL 161
P +KL+ + H+ ++F L GTV + P + ++ IH+
Sbjct: 180 TPVLKLS-----CSDTHINEMMVFVLGGTVLIVPFLCIVTSYIHI 219
>gi|169166402 PREDICTED: claudin-24-like [Homo sapiens]
Length = 220
Score = 28.1 bits (61), Expect = 7.3
Identities = 33/129 (25%), Positives = 55/129 (42%), Gaps = 18/129 (13%)
Query: 28 TLLPNWRKLRLITFNRNE-KNLTVYTGLWVKCA-RYDGSSDCLMYDTTWYSSVDQLDLRV 85
T LP+W+ L L + NE +N T+ GLW C + + C +D+ + R+
Sbjct: 28 TYLPHWKNLNL---DLNEMENWTM--GLWQTCVIQEEVGMQCKDFDSFLALPAELRVSRI 82
Query: 86 LQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLVAGLLFFLAGT 145
L F + +G L L + G R L + L+ ++ G+L + +G
Sbjct: 83 LMF-----LSNGLGFLGLLVSGFGLDCLRIGESQRDLKRRLL------ILGGILSWASGI 131
Query: 146 VSLSPSIWV 154
+L P WV
Sbjct: 132 TALVPVSWV 140
>gi|4507397 transcription factor 2 [Homo sapiens]
Length = 557
Score = 28.1 bits (61), Expect = 7.3
Identities = 17/51 (33%), Positives = 23/51 (45%), Gaps = 6/51 (11%)
Query: 200 KSLPSPFWQPLYSHPPSMHTYSQPYSA------RSRLSAIEIDIPVVSHTT 244
+ L SP QPL P H QP+ A S + A + + P SHT+
Sbjct: 476 QQLHSPHQQPLMQQSPGSHMAQQPFMAAVTQLQNSHMYAHKQEPPQYSHTS 526
>gi|50897282 olfactory receptor, family 8, subfamily D, member 1
[Homo sapiens]
Length = 308
Score = 28.1 bits (61), Expect = 7.3
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 8/98 (8%)
Query: 60 RYDGSSDCLMYD---TTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSS 116
RY L+Y+ ++W S+ L L F L+ AM L C + N F
Sbjct: 122 RYVAICSPLLYNAIMSSWVCSLLVLAAFFLGFLSALTHTSAMMKLSFCKSHIINHYFCDV 181
Query: 117 VPNIKLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWV 154
+P + L+ + HL LLF +AG +L P++ V
Sbjct: 182 LPLLNLS-----CSNTHLNELLLFIIAGFNTLVPTLAV 214
>gi|157412255 praja 2, RING-H2 motif containing [Homo sapiens]
Length = 708
Score = 27.7 bits (60), Expect = 9.5
Identities = 10/27 (37%), Positives = 14/27 (51%)
Query: 54 LWVKCARYDGSSDCLMYDTTWYSSVDQ 80
L +KC YDG DC+ D + + Q
Sbjct: 360 LLIKCEEYDGEHDCMFLDPPYSRVITQ 386
>gi|210147462 von Willebrand factor A domain containing 5B1 [Homo
sapiens]
Length = 1215
Score = 27.7 bits (60), Expect = 9.5
Identities = 22/85 (25%), Positives = 41/85 (48%), Gaps = 1/85 (1%)
Query: 76 SSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNIKLAKCLVNSAGCHLV 135
SS+ + + ++ A+ +++ M A L +IG +T F+S P+ + + C +
Sbjct: 370 SSMSGISMHRVKDAMLVALKSLMPACLFNIIGFGST-FKSLFPSSQTYSEDSLAMACDDI 428
Query: 136 AGLLFFLAGTVSLSPSIWVIFYNIH 160
+ + GT LSP WVI +H
Sbjct: 429 QRMKADMGGTNILSPLKWVIRQPVH 453
>gi|66932941 XC chemokine receptor 1 [Homo sapiens]
Length = 333
Score = 27.7 bits (60), Expect = 9.5
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 10/53 (18%)
Query: 64 SSDCLMYDTTWY-SSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRS 115
SS C + TWY +SV Q +L L+++G +L C + + T FRS
Sbjct: 172 SSGCDYSELTWYLTSVYQHNL---------FFLLSLGIILFCYVEILRTLFRS 215
>gi|4885339 XC chemokine receptor 1 [Homo sapiens]
Length = 333
Score = 27.7 bits (60), Expect = 9.5
Identities = 18/53 (33%), Positives = 27/53 (50%), Gaps = 10/53 (18%)
Query: 64 SSDCLMYDTTWY-SSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRS 115
SS C + TWY +SV Q +L L+++G +L C + + T FRS
Sbjct: 172 SSGCDYSELTWYLTSVYQHNL---------FFLLSLGIILFCYVEILRTLFRS 215
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.139 0.451
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,941,870
Number of Sequences: 37866
Number of extensions: 361642
Number of successful extensions: 1082
Number of sequences better than 10.0: 29
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 1074
Number of HSP's gapped (non-prelim): 30
length of query: 244
length of database: 18,247,518
effective HSP length: 99
effective length of query: 145
effective length of database: 14,498,784
effective search space: 2102323680
effective search space used: 2102323680
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.