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Search of human proteins with 68299759
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
(810 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 1589 0.0
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 991 0.0
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 987 0.0
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 269 9e-72
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 246 6e-65
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 181 2e-45
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 181 3e-45
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 151 3e-36
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 151 3e-36
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 142 1e-33
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 129 8e-30
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 129 1e-29
gi|148806902 TBC1 domain family, member 12 [Homo sapiens] 122 1e-27
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 120 4e-27
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 119 9e-27
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 115 2e-25
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 114 4e-25
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 111 3e-24
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 108 2e-23
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 108 2e-23
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 107 4e-23
gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens] 107 4e-23
gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens] 107 4e-23
gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens] 107 4e-23
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 105 1e-22
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 94 7e-19
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 88 3e-17
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 88 3e-17
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 88 4e-17
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 87 5e-17
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 1589 bits (4114), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 60
MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS
Sbjct: 1 MVTNKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTS 60
Query: 61 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 120
SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS
Sbjct: 61 SSTTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSS 120
Query: 121 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 180
SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ
Sbjct: 121 SSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ 180
Query: 181 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 240
SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE
Sbjct: 181 SMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDRE 240
Query: 241 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 300
VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE
Sbjct: 241 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQE 300
Query: 301 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 360
HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL
Sbjct: 301 HLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALL 360
Query: 361 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 420
QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT
Sbjct: 361 QMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKT 420
Query: 421 KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA 480
KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA
Sbjct: 421 KEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCA 480
Query: 481 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ 540
LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ
Sbjct: 481 LKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQ 540
Query: 541 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH 600
RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH
Sbjct: 541 RHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNH 600
Query: 601 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA 660
LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA
Sbjct: 601 LRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSIAA 660
Query: 661 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP 720
VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP
Sbjct: 661 VAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSGQP 720
Query: 721 PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET 780
PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET
Sbjct: 721 PFDGIHIVNHLIGDDESFHSSDEDFIDNSLQETGVGFPLHGKSGSMSLDPAVADGSESET 780
Query: 781 EDSVLETRESNQVVQKERPPRRRESYSTTV 810
EDSVLETRESNQVVQKERPPRRRESYSTTV
Sbjct: 781 EDSVLETRESNQVVQKERPPRRRESYSTTV 810
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 991 bits (2563), Expect = 0.0
Identities = 518/748 (69%), Positives = 601/748 (80%), Gaps = 54/748 (7%)
Query: 45 MASQVASPSTSLHTTSSSTTLSTPALSPSSPSQ-LSPDDLELLAKLEEQNRLLETDSKSL 103
MAS SP +S S LS P SP+S S+ LSPD+LELLAKLEEQNRLLE DSKS+
Sbjct: 1 MASPTLSPDSS-----SQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSM 55
Query: 104 RSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKG 163
RS+NGSRRNSGSSLVSSSSASSNLSHLEED+WILWGRI NEWE+ R++KEK +KEL+ KG
Sbjct: 56 RSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKG 115
Query: 164 IPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLG 223
IPHHFRAIVWQLLCSA MP+K+QYSELLKM+SPCEKLIRRDIARTYPEH FFK +DSLG
Sbjct: 116 IPHHFRAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLG 175
Query: 224 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPS 283
QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV+LMQ+YRLRELFKPS
Sbjct: 176 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPS 235
Query: 284 MAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDI 343
MAELGLC+YQFE M+QE LP+L HF+SQSFHTSMYASSWFLT+FLTTFPLP+ATR+FDI
Sbjct: 236 MAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295
Query: 344 FMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKY 403
FM EGLEIVFRVGLALLQ+NQAELMQLDMEGM Q+FQ+VIPHQFD PDKL+ AYQVKY
Sbjct: 296 FMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKY 355
Query: 404 NSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEK--------------- 448
N KKMK+LEKEY +K+KEMEEQ+EIKRLRTENRLLKQRIETLEK
Sbjct: 356 NPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKGQVTRAQEAEENYVI 415
Query: 449 --------HKCSS----------------------NYNEDFVLQLEKELVQARLSEAESQ 478
+CSS EDFV LE EL Q+RL E E+
Sbjct: 416 KRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLRETETL 475
Query: 479 CALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKELRQQVKDLEEH 538
AL+EMQDKVLD+EKRN+SLPDENN+A+LQEEL A+K+RE +A+ +EL+ Q+++L +
Sbjct: 476 GALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRELKLQLQELSDT 535
Query: 539 WQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINS 598
WQ HLAR GRWK+ P+K + ELQDELM++RLREA+ AE RE++QR++E+ETQ+ I+
Sbjct: 536 WQAHLAR-GGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRVVELETQDHIHR 594
Query: 599 NHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEVMAVRLREADSI 658
N L R E E +LQEK+QYL+AQNKGL TQLSE++RKQAE ECK+KEEVMAVRLREADS+
Sbjct: 595 NLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEVMAVRLREADSM 654
Query: 659 AAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHELRCLKGQRGFSG 718
AAVAE+RQ IAELEIQ+EEG++QGQLN SDS+QYI ELKDQI EL E+R LKG F
Sbjct: 655 AAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEVRLLKGPPPFED 714
Query: 719 QPPFDGIHIVNHLIGDDESFHSSDEDFI 746
FDG+ + HL D++S SSDE+ +
Sbjct: 715 PLAFDGLSLARHL--DEDSLPSSDEELL 740
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 987 bits (2552), Expect = 0.0
Identities = 518/759 (68%), Positives = 601/759 (79%), Gaps = 65/759 (8%)
Query: 45 MASQVASPSTSLHTTSSSTTLSTPALSPSSPSQ-LSPDDLELLAKLEEQNRLLETDSKSL 103
MAS SP +S S LS P SP+S S+ LSPD+LELLAKLEEQNRLLE DSKS+
Sbjct: 1 MASPTLSPDSS-----SQEALSAPTCSPTSDSENLSPDELELLAKLEEQNRLLEADSKSM 55
Query: 104 RSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKG 163
RS+NGSRRNSGSSLVSSSSASSNLSHLEED+WILWGRI NEWE+ R++KEK +KEL+ KG
Sbjct: 56 RSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRIANEWEEWRRRKEKLLKELIRKG 115
Query: 164 IPHHFRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLG 223
IPHHFRAIVWQLLCSA MP+K+QYSELLKM+SPCEKLIRRDIARTYPEH FFK +DSLG
Sbjct: 116 IPHHFRAIVWQLLCSATDMPVKNQYSELLKMSSPCEKLIRRDIARTYPEHEFFKGQDSLG 175
Query: 224 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPS 283
QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV+LMQ+YRLRELFKPS
Sbjct: 176 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKPS 235
Query: 284 MAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDI 343
MAELGLC+YQFE M+QE LP+L HF+SQSFHTSMYASSWFLT+FLTTFPLP+ATR+FDI
Sbjct: 236 MAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDI 295
Query: 344 FMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKY 403
FM EGLEIVFRVGLALLQ+NQAELMQLDMEGM Q+FQ+VIPHQFD PDKL+ AYQVKY
Sbjct: 296 FMYEGLEIVFRVGLALLQVNQAELMQLDMEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKY 355
Query: 404 NSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEK--------------- 448
N KKMK+LEKEY +K+KEMEEQ+EIKRLRTENRLLKQRIETLEK
Sbjct: 356 NPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVT 415
Query: 449 -------------------HKCSS----------------------NYNEDFVLQLEKEL 467
+CSS EDFV LE EL
Sbjct: 416 RAQEAEENYVIKRELAVVRQQCSSAAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETEL 475
Query: 468 VQARLSEAESQCALKEMQDKVLDIEKRNNSLPDENNIARLQEELIAVKLREAEAIMGLKE 527
Q+RL E E+ AL+EMQDKVLD+EKRN+SLPDENN+A+LQEEL A+K+RE +A+ +E
Sbjct: 476 EQSRLRETETLGALREMQDKVLDMEKRNSSLPDENNVAQLQEELKALKVREGQAVASTRE 535
Query: 528 LRQQVKDLEEHWQRHLARTTGRWKDPPKKNAMNELQDELMTIRLREAETQAEIREIKQRM 587
L+ Q+++L + WQ HLAR GRWK+ P+K + ELQDELM++RLREA+ AE RE++QR+
Sbjct: 536 LKLQLQELSDTWQAHLAR-GGRWKESPRKLVVGELQDELMSVRLREAQALAEGRELRQRV 594
Query: 588 MEMETQNQINSNHLRRAEQEVISLQEKVQYLSAQNKGLLTQLSEAKRKQAEIECKNKEEV 647
+E+ETQ+ I+ N L R E E +LQEK+QYL+AQNKGL TQLSE++RKQAE ECK+KEEV
Sbjct: 595 VELETQDHIHRNLLNRVEAERAALQEKLQYLAAQNKGLQTQLSESRRKQAEAECKSKEEV 654
Query: 648 MAVRLREADSIAAVAELRQHIAELEIQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHEL 707
MAVRLREADS+AAVAE+RQ IAELEIQ+EEG++QGQLN SDS+QYI ELKDQI EL E+
Sbjct: 655 MAVRLREADSMAAVAEMRQRIAELEIQREEGRIQGQLNHSDSSQYIRELKDQIEELKAEV 714
Query: 708 RCLKGQRGFSGQPPFDGIHIVNHLIGDDESFHSSDEDFI 746
R LKG F FDG+ + HL D++S SSDE+ +
Sbjct: 715 RLLKGPPPFEDPLAFDGLSLARHL--DEDSLPSSDEELL 751
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 269 bits (687), Expect = 9e-72
Identities = 175/532 (32%), Positives = 282/532 (53%), Gaps = 49/532 (9%)
Query: 113 SGSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIV 172
SGS VS A L WG ++++W + KQ+ LV G+P R V
Sbjct: 524 SGSGDVSKECAEKILE--------TWGELLSKWHLNLNVRPKQLSSLVRNGVPEALRGEV 575
Query: 173 WQLLCSAQSMP-IKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVM 231
WQLL + + ++Y L+ SP + I RDI RT+P H++FK+ GQ+ L+ +
Sbjct: 576 WQLLAGCHNNDHLVEKYRILITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKIC 635
Query: 232 KAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCM 291
KAYS+ D E+GYCQG +F+ +LL+ MPEE+AF V VK+M DY LRELFK + +L
Sbjct: 636 KAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKF 695
Query: 292 YQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEI 351
YQ E ++QE++P+L+ HF S MYAS WFLT+F FPL + I D+ + EG+ +
Sbjct: 696 YQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISV 755
Query: 352 VFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPD--KLIQAAYQVKYNSKKMK 409
+F V L LL+ ++ +L+ D EG L+ F+ +P ++ + KL++ A +K + KK+K
Sbjct: 756 IFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEENAKKLMELACNMKISQKKLK 815
Query: 410 KLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYN------------- 456
K EKEY T++ ++ +++ I+R ENR L++ LE+ +
Sbjct: 816 KYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLD 875
Query: 457 --EDFVLQLEKELV--QARLSEAESQ--------CALKEMQDKVLD-----IEKRNNSLP 499
E+ L KEL+ + +L +AE + LKEM + LD I+K ++ +
Sbjct: 876 NAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRRELDKAESEIKKNSSIIG 935
Query: 500 DENNI-ARLQEELIAVKLREAEAIMGLKELRQQVKDLEEHWQRHLARTTGRWK--DPPKK 556
D I ++L E L + ++ + ++++RQ+V D E R GR K K+
Sbjct: 936 DYKQICSQLSERL---EKQQTANKVEIEKIRQKVDDCER--CREFFNKEGRVKGISSTKE 990
Query: 557 NAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEV 608
+ +E T++ + E + E+ + K +++E E + Q +HL A EV
Sbjct: 991 VLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEV 1042
Score = 35.8 bits (81), Expect = 0.16
Identities = 36/164 (21%), Positives = 72/164 (43%), Gaps = 13/164 (7%)
Query: 554 PKKNAMNELQDELMTIRLREAETQAEIREIKQRMMEMETQNQINSNHLRRAEQEVISLQE 613
PK+ E +LM + +Q ++++ ++ M Q + + R E+E LQE
Sbjct: 788 PKRYRSEENAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQE 847
Query: 614 KVQYLSAQNKGLLTQLSEAK--------RKQAEIECKNKEEVMAVRLREADSIAAVAELR 665
L +N L +L +K + + + NKE +M + + D+ L
Sbjct: 848 ANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLM-TKQKLIDAEEEKRRLE 906
Query: 666 QHIAELE--IQKEEGKLQGQLNKSDSNQYIGELKDQIAELNHEL 707
+ A+L+ ++E K + ++ K+ S IG+ K ++L+ L
Sbjct: 907 EESAQLKEMCRRELDKAESEIKKNSS--IIGDYKQICSQLSERL 948
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 246 bits (628), Expect = 6e-65
Identities = 119/299 (39%), Positives = 185/299 (61%), Gaps = 3/299 (1%)
Query: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQ-SMPIKDQYSELLKMTS 196
WG ++ +W + K + LV G+P RA VWQLL + + D+Y L+ S
Sbjct: 513 WGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDS 572
Query: 197 PCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLM 256
E +I RDI RT+P H++FK+ GQE L+ + KAYS+ D ++GYCQG +F+ +LL+
Sbjct: 573 AQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLL 632
Query: 257 QMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHT 316
MPEE+AFCV VK+M DY LR+L++ + +L YQ E ++QE LP+L HF +
Sbjct: 633 HMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEA 692
Query: 317 SMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGML 376
MYAS WFLT+F FPL + I D+ + EGL I+F V LALL+ ++ +L+Q D EG L
Sbjct: 693 HMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752
Query: 377 QHFQKVIPHQFDGVPD--KLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLR 433
+ F+ +P ++ + +L++ A +K +KK+KK EKEY T++ +++++ + R +
Sbjct: 753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEYQTMRESQLQQEDPMDRYK 811
Score = 31.2 bits (69), Expect = 4.0
Identities = 20/44 (45%), Positives = 23/44 (52%), Gaps = 2/44 (4%)
Query: 46 ASQVASPSTSLHTTSSSTTLSTPALSPSSPSQLSPDDLELLAKL 89
ASQ PS L S+T +STP PSSP L +D L KL
Sbjct: 93 ASQTNKPSLQLILDPSNTEISTP--RPSSPGGLPEEDSVLFNKL 134
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 181 bits (459), Expect = 2e-45
Identities = 118/427 (27%), Positives = 215/427 (50%), Gaps = 36/427 (8%)
Query: 85 LLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGR-IVN 143
LL ++E++N+ LE L+S + +++ I W + ++N
Sbjct: 852 LLLRMEKENQKLEASRDELQSRK------------VKLDYEEVGACQKEVLITWDKKLLN 899
Query: 144 EWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSA----QSMPIKDQ-----YSELLKM 194
+R E + L+ +G+P R +WQ L +P K Q Y ELLK
Sbjct: 900 CRAKIRCDME-DIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQ 958
Query: 195 TSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLL 254
+ + I D+ RT+P H +F + GQ LFN++KAYSL+D+EVGYCQG +F+ G+L
Sbjct: 959 LTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVL 1018
Query: 255 LMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSF 314
L+ M EE+AF + LM D R+ ++P M L + MYQ ++ ++ +L+ H +
Sbjct: 1019 LLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEI 1078
Query: 315 HTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD-ME 373
S+YA+ WFLT+F + F L R+FDI +G E++F+V L+LL + +M+ + E
Sbjct: 1079 SPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFE 1138
Query: 374 GMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTK------EMEEQV 427
+++ + +P +K+I +++ SK++ E EY ++ + E+
Sbjct: 1139 NIVEFLKNTLPDMNTSEMEKIITQVFEMDI-SKQLHAYEVEYHVLQDELQESSYSCEDSE 1197
Query: 428 EIKRL-RTENRLLKQRIETLEKHKCSSNYNEDFVLQLEKELVQARLSEAESQCALKEMQD 486
+++L R ++L +Q ++ LEK + + + LE L E + + ++ ++
Sbjct: 1198 TLEKLERANSQLKRQNMDLLEKLQVAHTK----IQALESNLENLLTRETKMKSLIRTLEQ 1253
Query: 487 KVLDIEK 493
+ + +K
Sbjct: 1254 EKMAYQK 1260
Score = 30.4 bits (67), Expect = 6.9
Identities = 18/82 (21%), Positives = 43/82 (52%), Gaps = 9/82 (10%)
Query: 409 KKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIETLEKHKCSSNYNE------DFVLQ 462
+K KE ++ K + +Q+ + R+ EN+ L+ + L+ K +Y E + ++
Sbjct: 833 RKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLIT 892
Query: 463 LEKELVQARLSEAESQCALKEM 484
+K+L+ R A+ +C ++++
Sbjct: 893 WDKKLLNCR---AKIRCDMEDI 911
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 181 bits (458), Expect = 3e-45
Identities = 115/389 (29%), Positives = 206/389 (52%), Gaps = 41/389 (10%)
Query: 154 KQVKELVHKGIPHHFRAIVWQLLCSA----QSMPIKDQ-----YSELLKMTSPCEKLIRR 204
+++ V +G+P H R +W+ L P K Q Y ELLK + + I
Sbjct: 791 EKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILI 850
Query: 205 DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAF 264
D+ RT+P H +F + GQ L+N++KAYSL+D+EVGYCQG +F+ G+LL+ M EEEAF
Sbjct: 851 DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAF 910
Query: 265 CVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWF 324
+ LM D LR+ ++P M L + MYQ ++ ++ +L+ H + S+YA+ WF
Sbjct: 911 KMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWF 970
Query: 325 LTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLD-MEGMLQHFQKVI 383
LT+F + FPL R+FD+ +G E++F+V L+LL ++ ++Q + +E ++ + +
Sbjct: 971 LTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTL 1030
Query: 384 PHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRI 443
P+ +K I +++ +K+++ E EY ++ EE ++ L QR+
Sbjct: 1031 PNLGLVQMEKTINQVFEMDI-AKQLQAYEVEYHVLQ----EELIDSSPLSD-----NQRM 1080
Query: 444 ETLEKHKCS-SNYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDIEKRNNSLPDEN 502
+ LEK S N D + QL ++ R+ E+ +K+L E
Sbjct: 1081 DKLEKTNSSLRKQNLDLLEQL--QVANGRIQSLEATI------EKLLSSE---------- 1122
Query: 503 NIARLQEELIAVKLREAEAIMGLKELRQQ 531
++L++ ++ ++L + + ++ELR++
Sbjct: 1123 --SKLKQAMLTLELERSALLQTVEELRRR 1149
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 151 bits (381), Expect = 3e-36
Identities = 93/291 (31%), Positives = 149/291 (51%), Gaps = 10/291 (3%)
Query: 129 HLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMP--IKD 186
HLE + W +++ WE + K ++ ++KGIP R VW LL M +D
Sbjct: 68 HLEIERTTKWLKMLKGWE--KYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 125
Query: 187 QYSELLKMTSPCEKLIRR---DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGY 243
YS+L C IR+ D+ RT+ +H F+++ + Q+ LF+V+ AYS+ + EVGY
Sbjct: 126 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 185
Query: 244 CQGSAFIVGLLLMQMPEEEAFCVFVKLMQ--DYRLRELFKPSMAELGLCMYQFECMIQEH 301
CQG + I LLLM M EE+AF VKL + + F +L E ++ +
Sbjct: 186 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 245
Query: 302 LPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQ 361
L +L H SQ +TS Y WF FL P + RI+DI++ EG ++ + +L+
Sbjct: 246 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 305
Query: 362 MNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLE 412
+++ LM+L ME +++ FQ+ + F D +I+ Q+ K KL+
Sbjct: 306 LHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIE-QLQISMTELKRAKLD 355
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 151 bits (381), Expect = 3e-36
Identities = 93/291 (31%), Positives = 149/291 (51%), Gaps = 10/291 (3%)
Query: 129 HLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMP--IKD 186
HLE + W +++ WE + K ++ ++KGIP R VW LL M +D
Sbjct: 85 HLEIERTTKWLKMLKGWE--KYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRD 142
Query: 187 QYSELLKMTSPCEKLIRR---DIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGY 243
YS+L C IR+ D+ RT+ +H F+++ + Q+ LF+V+ AYS+ + EVGY
Sbjct: 143 LYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGY 202
Query: 244 CQGSAFIVGLLLMQMPEEEAFCVFVKLMQ--DYRLRELFKPSMAELGLCMYQFECMIQEH 301
CQG + I LLLM M EE+AF VKL + + F +L E ++ +
Sbjct: 203 CQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKF 262
Query: 302 LPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQ 361
L +L H SQ +TS Y WF FL P + RI+DI++ EG ++ + +L+
Sbjct: 263 LSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILK 322
Query: 362 MNQAELMQLDMEGMLQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLE 412
+++ LM+L ME +++ FQ+ + F D +I+ Q+ K KL+
Sbjct: 323 LHKKHLMKLSMEELVEFFQETLAKDFFFEDDFVIE-QLQISMTELKRAKLD 372
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 142 bits (359), Expect = 1e-33
Identities = 92/295 (31%), Positives = 139/295 (47%), Gaps = 10/295 (3%)
Query: 76 SQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEED-- 133
+Q +DL +L++ + L +DS+ L R+ + SSA H D
Sbjct: 2 AQALGEDLVQPPELQDDSSSLGSDSE-LSGPGPYRQADRYGFIGGSSAEPGPGHPPADLI 60
Query: 134 --SWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ--YS 189
+ W + + WE ++ K+VK KGIP RA W LLC A Y
Sbjct: 61 RQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQ 120
Query: 190 ELLKMTSPCE--KLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGS 247
EL + + + I RD+ R +P H F GQ+ L V+KAY+L E GYCQ
Sbjct: 121 ELAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQ 180
Query: 248 AFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFV 307
+ +LLM +P EEAF V++ + Y L + P M + L F +++ LP +
Sbjct: 181 GPVAAVLLMHLPPEEAFWCLVQICEVY-LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHK 239
Query: 308 HFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQM 362
H Q +Y WFL +F + P P R++D F+SEG ++FRVGL L+++
Sbjct: 240 HLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVRL 294
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 129 bits (325), Expect = 8e-30
Identities = 86/291 (29%), Positives = 129/291 (44%), Gaps = 12/291 (4%)
Query: 75 PSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLEEDS 134
P + D+L L E N E + GS+ G+ + E
Sbjct: 30 PDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGAL----EEVPLEVLRQRESK 85
Query: 135 WILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSA----QSMPIKDQYSE 190
W+ ++N W+ KK K+++ KGIP R WQ L Q P K +
Sbjct: 86 WL---DMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELD 142
Query: 191 LLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFI 250
+ +I RD+ R +P H F + GQ+ LF V+KAY+L E GYCQ A I
Sbjct: 143 MSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPI 202
Query: 251 VGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310
+LLM MP E+AF V++ + Y L + + + L ++Q+ P H
Sbjct: 203 AAVLLMHMPAEQAFWCLVQICEKY-LPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLS 261
Query: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQ 361
Q +Y + WF+ F T P R++D+F EG++I+FRVGL LL+
Sbjct: 262 RQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLK 312
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 129 bits (323), Expect = 1e-29
Identities = 96/343 (27%), Positives = 163/343 (47%), Gaps = 23/343 (6%)
Query: 66 STPALSP--SSPSQLSPDDLELLAKLEEQNRLLET---DSKSLRS---VNGSRRNS---- 113
ST +L P S P +PD L L + + LE+ D S+ S +NG
Sbjct: 248 STSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLALRKTDKY 307
Query: 114 ---GSSLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRA 170
G S S S SS + + W + + W+ ++ ++VK KGIP RA
Sbjct: 308 GFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRA 367
Query: 171 IVWQLLCSAQSMPIKD--QYSELLKMTSPCEKL--IRRDIARTYPEHNFFKEKDSLGQEV 226
WQ L +++ + ++ ++ EL + + L I +D+ R +P H F + GQ+
Sbjct: 368 KAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQD 427
Query: 227 LFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAE 286
L+ ++KAY++ + GYCQ A + +LLM MP E+AF V++ Y L + +
Sbjct: 428 LYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKY-LPGYYSAGLEA 486
Query: 287 LGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMS 346
+ L F +++ P H + Q +Y + WF+ IF T P R++D+F
Sbjct: 487 IQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFC 546
Query: 347 EGLEIVFRVGLALLQMNQAELMQL-DMEGMLQHFQKV--IPHQ 386
EG++I+FRV L LL+ + +L +GM + +++ +P Q
Sbjct: 547 EGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQ 589
>gi|148806902 TBC1 domain family, member 12 [Homo sapiens]
Length = 775
Score = 122 bits (306), Expect = 1e-27
Identities = 100/386 (25%), Positives = 171/386 (44%), Gaps = 44/386 (11%)
Query: 52 PSTSLHTTSSSTTLSTPALS-PSSPSQLSPDDLE--LLAKLEEQNRLLETDSKSLRSVNG 108
P +S LST AL PS L +E L + E + E + ++ +
Sbjct: 379 PQSSRRKNFEFEPLSTTALILEDRPSNLPAKSVEEALRHRQEYDEMVAEAKKREIKEAHK 438
Query: 109 SRRNSGSSLVSSSSASSNLSHLEEDSWILW-GRIVNEWEDVRKKKEKQVKELVHKGIPHH 167
+R + +S + ++W I+ WE +R + +V+EL +G+P
Sbjct: 439 RKRIMKERFKQEENIASAM--------VIWINEILPNWEVMRSTR--RVRELWWQGLPPS 488
Query: 168 FRAIVWQLLCSAQSMPIKDQYSELLKMTSPCEK------------------------LIR 203
R VW L + + Y L K LI+
Sbjct: 489 VRGKVWSLAVGNELNITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIK 548
Query: 204 RDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEA 263
DI+RT+P F +K +VL +++ AY+ +VGY QG +FI +L++ + E +A
Sbjct: 549 LDISRTFPSLYIF-QKGGPYHDVLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLEEADA 607
Query: 264 FCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSW 323
F F L+ F+ + + FE +E+L +LF+HF+S S +Y W
Sbjct: 608 FIAFANLLNKPCQLAFFRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDW 667
Query: 324 FLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVI 383
T++ + PL +A R++D+F +G E +FR GL +L++ + L+Q+D + Q K +
Sbjct: 668 IFTLYSKSLPLDLACRVWDVFCRDGEEFLFRTGLGILRLYEDILLQMDFIHIAQFLTK-L 726
Query: 384 PHQFDGVPDKLIQ--AAYQVKYNSKK 407
P D +KL AA Q++ ++KK
Sbjct: 727 PE--DITSEKLFSCIAAIQMQNSTKK 750
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 120 bits (302), Expect = 4e-27
Identities = 96/374 (25%), Positives = 163/374 (43%), Gaps = 34/374 (9%)
Query: 67 TPALSPSSPSQLSPDDLELLAKLEEQNRLLET-----DSKSLRSVNGSRRNSGSSLVSSS 121
TPA P S S E+LAK ++ E D R GSSL+++S
Sbjct: 6 TPACGPFSALTPSIWPQEILAKYTQKEESAEQPEFYYDEFGFRVYKEEGDEPGSSLLANS 65
Query: 122 ------------SASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFR 169
A +H + + W +I V + ++++ LV GIPH R
Sbjct: 66 PLMEDAPQRLRWQAHLEFTHNHDVGDLTWDKIA-----VSLPRSEKLRSLVLAGIPHGMR 120
Query: 170 AIVWQLLCSAQSMPIKDQ--YSELLKMTSPCE----KLIRRDIARTYPEHNFFKEKDSLG 223
+W L A + Y E++K +S E K I +D+ RT P + F S+G
Sbjct: 121 PQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQIEKDLLRTMPSNACFASMGSIG 180
Query: 224 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPS 283
L V++A + + E+GYCQG+ + LL+ + EE+AF + +++D F +
Sbjct: 181 VPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAIIEDLLPASYFSTT 240
Query: 284 MAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDI 343
+ + +I ++LP L Q S+ WFLT F + + + RI+D+
Sbjct: 241 LLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFASVVDIKLLLRIWDL 300
Query: 344 FMSEGLEIVFRVGLALLQMNQAELMQLDMEGMLQHFQKVIPHQFD------GVPDKLIQA 397
F EG ++F++ L +L + + EL+Q + + + IP Q + GV +L +
Sbjct: 301 FFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDAELLLGVAMRLAGS 360
Query: 398 AYQVKYNSKKMKKL 411
V +++ K L
Sbjct: 361 LTDVAVETQRRKHL 374
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 119 bits (299), Expect = 9e-27
Identities = 118/486 (24%), Positives = 220/486 (45%), Gaps = 62/486 (12%)
Query: 13 PSGKQVATDKVAEKLSSTLSWVKNTVS---HTVSQMASQVA-------SPSTSLHTTSSS 62
P + +A DK + S + +K + H V VA + ST H S+
Sbjct: 342 PLREVLAIDKTNDSSKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTE 401
Query: 63 TTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSS 122
+S+ + PS D+ E+ + ++ ++++L +V + + + +
Sbjct: 402 LAISSESTEPS-------DNFEVQSLTSQRECSKTVNTEALMTVFHPQN------LETLN 448
Query: 123 ASSNLSHLEEDSW-ILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQS 181
+ ++E SW IL+ V + K+ ++LV +GIP R +W L A +
Sbjct: 449 SKMLKEKMKEQSWKILFAEC---GRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVN 505
Query: 182 --MPIKDQYSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYS 235
D Y+E+++ + L I RD+ R+ PEH F+ G L V+ AY+
Sbjct: 506 DMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQS--DTGISALRRVLTAYA 563
Query: 236 LVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV----KLMQDYRLRELFKPSMAELGLCM 291
+ ++GYCQ + +LL+ EEEAF + V +++ DY R + +G +
Sbjct: 564 YRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI-------IGALV 616
Query: 292 YQ--FECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGL 349
Q FE +I++HLP+L H +F +S+ + SWFLT+F++ P+ A + D F +G+
Sbjct: 617 DQAVFEELIRDHLPQLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGI 675
Query: 350 EIVFRVGLALLQMNQAELMQL--DMEGM--LQHFQKVIPHQFDGVPDKLIQAAYQVKYNS 405
+ + ++GLA+L N +L+ D E + L F + ++ +P + Q + +
Sbjct: 676 KAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGS---NVSD 732
Query: 406 KKMKKLEKEYTTIKTKEMEE-----QVEIKRLRTENRL-LKQRIETLEKHKCSSNYNEDF 459
+K + T + + E+ +I +R NRL + Q +E K ++D
Sbjct: 733 EKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDV 792
Query: 460 VLQLEK 465
L L++
Sbjct: 793 KLSLQE 798
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 115 bits (287), Expect = 2e-25
Identities = 78/314 (24%), Positives = 151/314 (48%), Gaps = 15/314 (4%)
Query: 155 QVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ---------YSELLKMTSPCEKLIRRD 205
++K L+ GIPH R+ VW+ + KD + L+ +P K I D
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELD 713
Query: 206 IARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFC 265
+ RT P + + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 714 LLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFW 773
Query: 266 VFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 325
V +++ + R+ + ++ + F ++ E LP L HF+ ++ +WFL
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833
Query: 326 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL-DMEGMLQHFQKVIP 384
+F+ + I +I+D F+ EG +++FR LAL + + E+++L D + ++ +
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTR 893
Query: 385 HQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIE 444
D KLI ++ N ++++ K E E++ +R + L++R
Sbjct: 894 TILDA--RKLISISFG-DLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED--FLRERDT 948
Query: 445 TLEKHKCSSNYNED 458
+ +K + S+ ED
Sbjct: 949 SPDKGELVSDEEED 962
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 114 bits (285), Expect = 4e-25
Identities = 62/225 (27%), Positives = 115/225 (51%), Gaps = 9/225 (4%)
Query: 155 QVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ---------YSELLKMTSPCEKLIRRD 205
++K L+ GIPH R+ VW+ + KD + L+ +P K I D
Sbjct: 654 ELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELD 713
Query: 206 IARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFC 265
+ RT P + + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 714 LLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFW 773
Query: 266 VFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 325
V +++ + R+ + ++ + F ++ E LP L HF+ ++ +WFL
Sbjct: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833
Query: 326 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370
+F+ + I +I+D F+ EG +++FR LAL + + E+++L
Sbjct: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKL 878
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 111 bits (277), Expect = 3e-24
Identities = 98/396 (24%), Positives = 177/396 (44%), Gaps = 33/396 (8%)
Query: 4 NKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSST 63
N+MT F N + ++++ L T S + ++ + A S +++ SS
Sbjct: 376 NRMTFLFANLKDRDFLVQRISDFLQQTTSKI-----YSDKEFAGSYNSSDDEVYSRPSSL 430
Query: 64 TLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSSA 123
S+P S SS D + + + T +++L ++ RR S +
Sbjct: 431 VSSSPQRSTSS-------DADGERQFNLNGNSVPTATQTLMTMY--RRRSPEEFNPKLAK 481
Query: 124 SSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSA--QS 181
L+E +W + + + + ++ +ELV KGIP R +W LL A +
Sbjct: 482 E----FLKEQAWKI--HFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEK 535
Query: 182 MPIKDQYSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLV 237
Y +L++ + L I RD+ R+ PEH F+ + +G L V+ AY+
Sbjct: 536 ATHPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNE--MGIAALRRVLTAYAFR 593
Query: 238 DREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECM 297
+ +GYCQ + +LL+ EEEAF + V L + L + + + + FE +
Sbjct: 594 NPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERM-LPDYYNTRVVGALVDQGVFEEL 652
Query: 298 IQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGL 357
++++P+L+ Q S + SWFLT+FL+ P A + D F EG++++F++ L
Sbjct: 653 ARDYVPQLYDCMQDLGV-ISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLAL 711
Query: 358 ALLQMNQAELMQLDMEGMLQHFQKVIPHQFDGVPDK 393
A+L N +L+ +G V+ D V +K
Sbjct: 712 AVLDANVDKLLNCKDDG---EAMTVLGRYLDSVTNK 744
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 108 bits (270), Expect = 2e-23
Identities = 103/385 (26%), Positives = 171/385 (44%), Gaps = 48/385 (12%)
Query: 4 NKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSST 63
+KMT F N + ++++ L T S ++ S+ AS V PST ++ +
Sbjct: 371 SKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIG---SRKAS-VVDPSTE--SSPAPQ 424
Query: 64 TLSTPALSPSSP--------SQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGS 115
S SP+SP +Q +P + L KL ++N +E
Sbjct: 425 EGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPME------------------ 466
Query: 116 SLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQL 175
A ++E+SW + V + + + LV KGIP R +W L
Sbjct: 467 ----DLGAKGAKEKMKEESWHI--HFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLL 520
Query: 176 LCSAQSMPIKDQ--YSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFN 229
A + + Y+EL++ ++ L I RD+ R+ PEH F+ + LG L
Sbjct: 521 FSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNE--LGIAALRR 578
Query: 230 VMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGL 289
V+ AY+ + +GYCQ + +LL+ EEEAF + V L + L + + + +
Sbjct: 579 VLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERM-LPDYYNTRVVGALV 637
Query: 290 CMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGL 349
FE + ++ LP+L Q +S+ + SWFLT+FL+ P A I D F EG+
Sbjct: 638 DQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLFLSVMPFESAVVIVDCFFYEGI 696
Query: 350 EIVFRVGLALLQMNQAELMQLDMEG 374
+++ +V LA+L N +L+ EG
Sbjct: 697 KVILQVALAVLDANMEQLLGCSDEG 721
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 108 bits (270), Expect = 2e-23
Identities = 103/385 (26%), Positives = 171/385 (44%), Gaps = 48/385 (12%)
Query: 4 NKMTAAFRNPSGKQVATDKVAEKLSSTLSWVKNTVSHTVSQMASQVASPSTSLHTTSSST 63
+KMT F N + ++++ L T S ++ S+ AS V PST ++ +
Sbjct: 371 SKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIG---SRKAS-VVDPSTE--SSPAPQ 424
Query: 64 TLSTPALSPSSP--------SQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGS 115
S SP+SP +Q +P + L KL ++N +E
Sbjct: 425 EGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPME------------------ 466
Query: 116 SLVSSSSASSNLSHLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQL 175
A ++E+SW + V + + + LV KGIP R +W L
Sbjct: 467 ----DLGAKGAKEKMKEESWHI--HFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLL 520
Query: 176 LCSAQSMPIKDQ--YSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFN 229
A + + Y+EL++ ++ L I RD+ R+ PEH F+ + LG L
Sbjct: 521 FSGAWNEMVTHPGYYAELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNE--LGIAALRR 578
Query: 230 VMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGL 289
V+ AY+ + +GYCQ + +LL+ EEEAF + V L + L + + + +
Sbjct: 579 VLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERM-LPDYYNTRVVGALV 637
Query: 290 CMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGL 349
FE + ++ LP+L Q +S+ + SWFLT+FL+ P A I D F EG+
Sbjct: 638 DQGIFEELTRDFLPQLSEKMQDLGVISSI-SLSWFLTLFLSVMPFESAVVIVDCFFYEGI 696
Query: 350 EIVFRVGLALLQMNQAELMQLDMEG 374
+++ +V LA+L N +L+ EG
Sbjct: 697 KVILQVALAVLDANMEQLLGCSDEG 721
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 107 bits (267), Expect = 4e-23
Identities = 71/224 (31%), Positives = 117/224 (52%), Gaps = 7/224 (3%)
Query: 152 KEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ--YSELLK--MTSPCEKLIRRDIA 207
+ + VK V KG+P RA VW +L AQ+ ++ Y +LL+ E IR D+
Sbjct: 57 RSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLN 116
Query: 208 RTYPEH-NFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG-LLLMQMPEEEAFC 265
RT+P++ F K D Q L+NV+ AY ++ VGYCQG FI G L+L+ EEE+F
Sbjct: 117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFW 176
Query: 266 VFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 325
+ L+ L + + P+M L +++ LP + + ++ S WF+
Sbjct: 177 LLDALVGRI-LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFI 235
Query: 326 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQ 369
+F+ P+ RI+D +EG +I+FRV L L++ +Q +++
Sbjct: 236 CLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILE 279
>gi|164565381 TBC1 domain family, member 14 isoform b [Homo sapiens]
Length = 413
Score = 107 bits (267), Expect = 4e-23
Identities = 97/412 (23%), Positives = 178/412 (43%), Gaps = 49/412 (11%)
Query: 47 SQVASPSTSLHTTSSSTTLSTPALS-PSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRS 105
S+ SP ++ LST AL P+ L E K +Q + +K
Sbjct: 11 SKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKREL 70
Query: 106 VNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGR-IVNEWEDVRKKKEKQVKELVHKGI 164
RR L ++ + + + W I+ WE + ++ V++L +GI
Sbjct: 71 KEAQRRKK--QLEERCRVEESIGN----AVLTWNNEILPNWETMWCSRK--VRDLWWQGI 122
Query: 165 PHHFRAIVWQL--------------LCSAQSMPIKDQYSELLKMTSPCE----------- 199
P R VW L +C A++ K+++ L S E
Sbjct: 123 PPSVRGKVWSLAIGNELNITHELFDICLARA---KERWRSLSTGGSEVENEDAGFSAADR 179
Query: 200 ----KLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 255
+LI+ DI+RT+P F++ ++L +++ AY+ +VGY QG +FI +L+
Sbjct: 180 EASLELIKLDISRTFPNLCIFQQGGPY-HDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 238
Query: 256 MQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFH 315
+ + +AF F L+ F+ + FE +E+LP+LF HF+ +
Sbjct: 239 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 298
Query: 316 TSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGM 375
+Y W T++ + PL +A RI+D+F +G E +FR L +L++ + L ++D M
Sbjct: 299 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHM 358
Query: 376 LQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIK--TKEMEE 425
Q ++ + +P + + A+ + KK + T ++ ++EME+
Sbjct: 359 AQFLTRLP----EDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK 406
>gi|164565368 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 107 bits (267), Expect = 4e-23
Identities = 97/412 (23%), Positives = 178/412 (43%), Gaps = 49/412 (11%)
Query: 47 SQVASPSTSLHTTSSSTTLSTPALS-PSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRS 105
S+ SP ++ LST AL P+ L E K +Q + +K
Sbjct: 291 SKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKREL 350
Query: 106 VNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGR-IVNEWEDVRKKKEKQVKELVHKGI 164
RR L ++ + + + W I+ WE + ++ V++L +GI
Sbjct: 351 KEAQRRKK--QLEERCRVEESIGN----AVLTWNNEILPNWETMWCSRK--VRDLWWQGI 402
Query: 165 PHHFRAIVWQL--------------LCSAQSMPIKDQYSELLKMTSPCE----------- 199
P R VW L +C A++ K+++ L S E
Sbjct: 403 PPSVRGKVWSLAIGNELNITHELFDICLARA---KERWRSLSTGGSEVENEDAGFSAADR 459
Query: 200 ----KLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 255
+LI+ DI+RT+P F++ ++L +++ AY+ +VGY QG +FI +L+
Sbjct: 460 EASLELIKLDISRTFPNLCIFQQGGPY-HDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518
Query: 256 MQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFH 315
+ + +AF F L+ F+ + FE +E+LP+LF HF+ +
Sbjct: 519 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 578
Query: 316 TSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGM 375
+Y W T++ + PL +A RI+D+F +G E +FR L +L++ + L ++D M
Sbjct: 579 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHM 638
Query: 376 LQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIK--TKEMEE 425
Q ++ + +P + + A+ + KK + T ++ ++EME+
Sbjct: 639 AQFLTRLP----EDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK 686
>gi|164565366 TBC1 domain family, member 14 isoform a [Homo sapiens]
Length = 693
Score = 107 bits (267), Expect = 4e-23
Identities = 97/412 (23%), Positives = 178/412 (43%), Gaps = 49/412 (11%)
Query: 47 SQVASPSTSLHTTSSSTTLSTPALS-PSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRS 105
S+ SP ++ LST AL P+ L E K +Q + +K
Sbjct: 291 SKPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAEEAQKHRQQYEEMVVQAKKREL 350
Query: 106 VNGSRRNSGSSLVSSSSASSNLSHLEEDSWILWGR-IVNEWEDVRKKKEKQVKELVHKGI 164
RR L ++ + + + W I+ WE + ++ V++L +GI
Sbjct: 351 KEAQRRKK--QLEERCRVEESIGN----AVLTWNNEILPNWETMWCSRK--VRDLWWQGI 402
Query: 165 PHHFRAIVWQL--------------LCSAQSMPIKDQYSELLKMTSPCE----------- 199
P R VW L +C A++ K+++ L S E
Sbjct: 403 PPSVRGKVWSLAIGNELNITHELFDICLARA---KERWRSLSTGGSEVENEDAGFSAADR 459
Query: 200 ----KLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLL 255
+LI+ DI+RT+P F++ ++L +++ AY+ +VGY QG +FI +L+
Sbjct: 460 EASLELIKLDISRTFPNLCIFQQGGPY-HDMLHSILGAYTCYRPDVGYVQGMSFIAAVLI 518
Query: 256 MQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFH 315
+ + +AF F L+ F+ + FE +E+LP+LF HF+ +
Sbjct: 519 LNLDTADAFIAFSNLLNKPCQMAFFRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLT 578
Query: 316 TSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQLDMEGM 375
+Y W T++ + PL +A RI+D+F +G E +FR L +L++ + L ++D M
Sbjct: 579 PDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDILTKMDFIHM 638
Query: 376 LQHFQKVIPHQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIK--TKEMEE 425
Q ++ + +P + + A+ + KK + T ++ ++EME+
Sbjct: 639 AQFLTRLP----EDLPAEELFASIATIQMQSRNKKWAQVLTALQKDSREMEK 686
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 105 bits (263), Expect = 1e-22
Identities = 80/271 (29%), Positives = 132/271 (48%), Gaps = 17/271 (6%)
Query: 111 RNSGSSLVSSSSASSNLS-HLEEDSWILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFR 169
+ SGS S + + L D ++ +GR V + + +++++LV GIP R
Sbjct: 458 QQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMF------RTEKIRKLVAMGIPESLR 511
Query: 170 AIVWQLLCSA----QSMP--IKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLG 223
+W L A S P + E L + I RD+ R+ PEH F+ + +
Sbjct: 512 GRLWLLFSDAVTDLASHPGYYGNLVEESLGKCCLVTEEIERDLHRSLPEHPAFQNETGIA 571
Query: 224 QEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPS 283
L V+ AY+ + ++GYCQ + +LL+ EEEAF + V + + L + F
Sbjct: 572 --ALRRVLTAYAHRNPKIGYCQSMNILTSVLLLYTKEEEAFWLLVAVCERM-LPDYFNHR 628
Query: 284 MAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDI 343
+ + FE +I+ HLPEL H S S+ + SWFLT+FL+ PL A + D
Sbjct: 629 VIGAQVDQSVFEELIKGHLPELAEHMNDLSALASV-SLSWFLTLFLSIMPLESAVNVVDC 687
Query: 344 FMSEGLEIVFRVGLALLQMNQAELMQLDMEG 374
F +G++ +F++GLA+L+ N +L +G
Sbjct: 688 FFYDGIKAIFQLGLAVLEANAEDLCSSKDDG 718
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 93.6 bits (231), Expect = 7e-19
Identities = 64/245 (26%), Positives = 114/245 (46%), Gaps = 9/245 (3%)
Query: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ-----YSELL 192
W ++ EWE K ++ + V+KGIP + R VW +L + Q + +K+ E
Sbjct: 77 WMEMLGEWETY--KHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERG 134
Query: 193 KMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 252
K +S I D+ T H FF+++ Q LF ++ AYS + EVGYC+ + I
Sbjct: 135 KRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITA 194
Query: 253 LLLMQMPEEEAFCVFVKLMQDYR--LRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310
L L+ +PEE+AF V+L+ R L P+ + Q E ++ + P+ H
Sbjct: 195 LFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQD 254
Query: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370
+ + L + L + R++D+++ EG +++ + L++ Q LM+
Sbjct: 255 KEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKT 314
Query: 371 DMEGM 375
G+
Sbjct: 315 SRCGL 319
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 88.2 bits (217), Expect = 3e-17
Identities = 59/249 (23%), Positives = 115/249 (46%), Gaps = 9/249 (3%)
Query: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ-----YSELL 192
W ++ +WE + K +++ + +KG+P + R +W +L + + M +K+ E
Sbjct: 78 WVDMLGDWE--KYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
Query: 193 KMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 252
K +S + I RDI+ T +H FF+++ Q L +++ AY + EVGYC+ + I
Sbjct: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 253 LLLMQMPEEEAFCVFVKLMQDYR--LRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310
L L+ +PEE+AF V+L+ R L+ P+ + Q E ++ P+ H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370
+ + I + L + R++D+++ EG + + + ++ Q L +
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKT 315
Query: 371 DMEGMLQHF 379
G F
Sbjct: 316 SRCGPWARF 324
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 88.2 bits (217), Expect = 3e-17
Identities = 59/249 (23%), Positives = 115/249 (46%), Gaps = 9/249 (3%)
Query: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ-----YSELL 192
W ++ +WE + K +++ + +KG+P + R +W +L + + M +K+ E
Sbjct: 78 WVDMLGDWE--KYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
Query: 193 KMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 252
K +S + I RDI+ T +H FF+++ Q L +++ AY + EVGYC+ + I
Sbjct: 136 KRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 253 LLLMQMPEEEAFCVFVKLMQDYR--LRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310
L L+ +PEE+AF V+L+ R L+ P+ + Q E ++ P+ H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370
+ + I + L + R++D+++ EG + + + ++ Q L +
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKT 315
Query: 371 DMEGMLQHF 379
G F
Sbjct: 316 SRCGPWARF 324
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 87.8 bits (216), Expect = 4e-17
Identities = 58/249 (23%), Positives = 115/249 (46%), Gaps = 9/249 (3%)
Query: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ-----YSELL 192
W ++ +WE + K +++ + +KG+P + R +W +L + + M +K+ E
Sbjct: 78 WVDMLGDWE--KYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKG 135
Query: 193 KMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 252
K +S + I RD++ T +H FF+++ Q L +++ AY + EVGYC+ + I
Sbjct: 136 KKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 253 LLLMQMPEEEAFCVFVKLMQDYR--LRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310
L L+ +PEE+AF V+L+ R L+ P+ + Q E ++ P+ H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370
+ + I + L + R++D+++ EG + + + ++ Q L +
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKT 315
Query: 371 DMEGMLQHF 379
G F
Sbjct: 316 SRCGPWARF 324
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 87.4 bits (215), Expect = 5e-17
Identities = 58/249 (23%), Positives = 115/249 (46%), Gaps = 9/249 (3%)
Query: 138 WGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ-----YSELL 192
W ++ +WE + K +++ + +KG+P + R +W +L + + M +K+ E
Sbjct: 78 WVDMLGDWE--KYKSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG 135
Query: 193 KMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVG 252
K +S + I RD++ T +H FF+++ Q L +++ AY + EVGYC+ + I
Sbjct: 136 KRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAA 195
Query: 253 LLLMQMPEEEAFCVFVKLMQDYR--LRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQ 310
L L+ +PEE+AF V+L+ R L+ P+ + Q E ++ P+ H
Sbjct: 196 LFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQD 255
Query: 311 SQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL 370
+ + I + L + R++D+++ EG + + + ++ Q L +
Sbjct: 256 KKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKT 315
Query: 371 DMEGMLQHF 379
G F
Sbjct: 316 SRCGPWARF 324
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,971,764
Number of Sequences: 37866
Number of extensions: 1305737
Number of successful extensions: 13061
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 923
Number of HSP's that attempted gapping in prelim test: 8202
Number of HSP's gapped (non-prelim): 3960
length of query: 810
length of database: 18,247,518
effective HSP length: 110
effective length of query: 700
effective length of database: 14,082,258
effective search space: 9857580600
effective search space used: 9857580600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.