Search of human proteins with 67906195

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|67906195 ankyrin repeat and sterile alpha motif domain
containing 6 [Homo sapiens]
         (871 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|67906195 ankyrin repeat and sterile alpha motif domain contai...  1741   0.0  
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   160   6e-39
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ...   148   2e-35
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]                    148   2e-35
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ...   148   2e-35
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ...   148   2e-35
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap...   145   1e-34
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap...   145   1e-34
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       129   9e-30
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        129   9e-30
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        129   9e-30
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        129   9e-30
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        129   9e-30
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        129   2e-29
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   119   1e-26
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       117   6e-26
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        117   6e-26
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        117   6e-26
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   113   9e-25
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi...   110   7e-24
gi|70995267 ankyrin repeat domain 29 [Homo sapiens]                   103   5e-22
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   103   7e-22
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  102   2e-21
gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled...   101   3e-21
gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled...   101   3e-21
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled...   101   3e-21
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]             96   2e-19
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                    95   2e-19
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]           95   2e-19
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]         95   2e-19

>gi|67906195 ankyrin repeat and sterile alpha motif domain
           containing 6 [Homo sapiens]
          Length = 871

 Score = 1741 bits (4508), Expect = 0.0
 Identities = 871/871 (100%), Positives = 871/871 (100%)

Query: 1   MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAA 60
           MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAA
Sbjct: 1   MGEGGLPPAFQLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAA 60

Query: 61  AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR 120
           AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR
Sbjct: 61  AAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAAR 120

Query: 121 FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQL 180
           FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQL
Sbjct: 121 FGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQL 180

Query: 181 GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV 240
           GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV
Sbjct: 181 GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV 240

Query: 241 AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL 300
           AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL
Sbjct: 241 AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL 300

Query: 301 KMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHG 360
           KMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHG
Sbjct: 301 KMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHG 360

Query: 361 WTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQ 420
           WTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQ
Sbjct: 361 WTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQ 420

Query: 421 VNKDKGRPSHQPPLPHSKVRQPWSIPVLPDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLS 480
           VNKDKGRPSHQPPLPHSKVRQPWSIPVLPDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLS
Sbjct: 421 VNKDKGRPSHQPPLPHSKVRQPWSIPVLPDDKGGLKSWWNRMSNRFRKLKLMQTLPRGLS 480

Query: 481 SNQPLPFSDEPEPALDSTMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTML 540
           SNQPLPFSDEPEPALDSTMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTML
Sbjct: 481 SNQPLPFSDEPEPALDSTMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTML 540

Query: 541 RNGAPLTRLPSDKLKAVIPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPV 600
           RNGAPLTRLPSDKLKAVIPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPV
Sbjct: 541 RNGAPLTRLPSDKLKAVIPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPV 600

Query: 601 GGGGTDTTPVRPVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGS 660
           GGGGTDTTPVRPVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGS
Sbjct: 601 GGGGTDTTPVRPVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGS 660

Query: 661 IDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSK 720
           IDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSK
Sbjct: 661 IDNVLSQIAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGSAPVGKKLETSK 720

Query: 721 RPPSGTSTTSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTG 780
           RPPSGTSTTSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTG
Sbjct: 721 RPPSGTSTTSKSTSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDEDELTG 780

Query: 781 ILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNAGKGRE 840
           ILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNAGKGRE
Sbjct: 781 ILKKLSLEKYQPIFEEQEVDMEAFLTLTDGDLKELGIKTDGSRQQILAAISELNAGKGRE 840

Query: 841 RQILQETIHNFHSSFESSASNTRAPGNSPCA 871
           RQILQETIHNFHSSFESSASNTRAPGNSPCA
Sbjct: 841 RQILQETIHNFHSSFESSASNTRAPGNSPCA 871


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  160 bits (404), Expect = 6e-39
 Identities = 126/401 (31%), Positives = 186/401 (46%), Gaps = 34/401 (8%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
           L  A  QG T+    L+  GA        + +       A   G     +  + A V VD
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANI---NHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVD 638

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
           C+D    TAL+ AA GGHE +V  LL+ GA VN  ++ G +AL+ AA  GH  +   LLD
Sbjct: 639 CADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698

Query: 133 HGADVNAQNRLGASVLTVA-----SRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRD 187
           HGA+VN ++  G + L+VA     +  GH  VV LL++ GA VDH    G          
Sbjct: 699 HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDG---------- 748

Query: 188 EPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEK 247
               +T L+ A   GH  VV LL+E GAD +H     G +PL+ AA  G   V   L+  
Sbjct: 749 ----MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN-GRTPLLAAASMGHASVVNTLLFW 803

Query: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDI----FHALKMG 303
           GA  D +    +T   +A           ++ + T+  +  +E  R D      H     
Sbjct: 804 GAAVDSIDSEGRTVLSIA------SAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFE 857

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
             +L+ E   E  +  N ++ DG  P +LA+  G    VQ+L+E  +++D Q    G  A
Sbjct: 858 GHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNID-QRGYDGRNA 916

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           L  A   G+++IV+ L + GADV  +  +G     ++ L N
Sbjct: 917 LRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957



 Score =  125 bits (314), Expect = 2e-28
 Identities = 103/337 (30%), Positives = 156/337 (46%), Gaps = 26/337 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+  D  G T L  AA  G   +V  L+ RGA +   + +G + L  AAR GH  V + L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD----HHHPSGEQLGLGGSR 186
           +  GA++N  ++ G + L  A+ GGH  VV  LL AG  VD        +      GG  
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHE 657

Query: 187 DEPLDI---------------TALMAAIQHGHEAVVRLLMEWGADPNH----AARTVGWS 227
           D  L++               TAL+AA   GH  +V  L++ GA+ NH        +  +
Sbjct: 658 DIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717

Query: 228 PLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKT 287
            L + A  G   V   L+++GA  DH      T   VA    H D+VD L         T
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHT 777

Query: 288 DEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVE 347
           D   R P +  A  MG+  +V  +     + V+ ++ +G T L +A+  G + +V+ L++
Sbjct: 778 DNNGRTP-LLAAASMGHASVVNTLLFWGAA-VDSIDSEGRTVLSIASAQGNVEVVRTLLD 835

Query: 348 RHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
           R  D + +D   GWT L  A + G++ I + L+ QGA
Sbjct: 836 RGLDENHRDDA-GWTPLHMAAFEGHRLICEALIEQGA 871



 Score =  124 bits (310), Expect = 5e-28
 Identities = 115/374 (30%), Positives = 162/374 (43%), Gaps = 25/374 (6%)

Query: 13   LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
            LL A  +G  +    LLE GA        G  P   A   G           GA      
Sbjct: 752  LLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAA----- 806

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            VD  D  G T L  A+A G+  +VR LL RG   N R+  GW+ L  AA  GH  +   L
Sbjct: 807  VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866

Query: 131  LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
            ++ GA  N  +  G     +AS+ GH   V++LLE  + +D     G             
Sbjct: 867  IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRN----------- 915

Query: 191  DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
               AL  A   GH  +V LL   GAD N      G   L + AL  +L +A+  +E GAN
Sbjct: 916  ---ALRVAALEGHRDIVELLFSHGADVN-CKDADGRPTLYILALENQLTMAEYFLENGAN 971

Query: 251  PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKE 310
             +      +TA  V+    H ++V  L          D EKR   +  A   G+ ++V +
Sbjct: 972  VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSA-LQSAAWQGHVKVV-Q 1029

Query: 311  IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYH 370
            +  E  + V+     GAT L +AA  G + +VQ+L+E  AD +  D   G TA+  A  +
Sbjct: 1030 LLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQF-GRTAMRVAAKN 1088

Query: 371  GNKEIVKYLLNQGA 384
            G+ +I+K L   GA
Sbjct: 1089 GHSQIIKLLEKYGA 1102



 Score =  119 bits (297), Expect = 2e-26
 Identities = 105/329 (31%), Positives = 157/329 (47%), Gaps = 28/329 (8%)

Query: 91  EPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTV 150
           E  +R LL  GASVN  +  G + L  AA  G + V +LL+  GAD+  ++  G + LT+
Sbjct: 525 EDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTL 584

Query: 151 ASRGGHLGVVKLLLEAGAFVDHHHPSG----------------EQLGLGGSRDEPLDI-- 192
           A+R GH  VV  L+  GA ++H    G                  L   G + +  D   
Sbjct: 585 AARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADS 644

Query: 193 -TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
            TAL AA   GHE +V  L++ GA+ N A    G + L+ AA  G   + + L++ GA  
Sbjct: 645 RTALRAAAWGGHEDIVLNLLQHGAEVNKADNE-GRTALIAAAYMGHREIVEHLLDHGAEV 703

Query: 252 DHLSVLEKTAFEVALDC-----KHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQ 306
           +H  V  +TA  VA  C      H  +V  L          D++   P +  A + G+  
Sbjct: 704 NHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE-GHVD 762

Query: 307 LVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQ 366
           +V ++  E  + V+  + +G TPL+ AA  G  ++V  L+   A VD  DS  G T L  
Sbjct: 763 VV-DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDS-EGRTVLSI 820

Query: 367 ATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           A+  GN E+V+ LL++G D   R   G+T
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWT 849



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 62/180 (34%), Positives = 91/180 (50%), Gaps = 15/180 (8%)

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            V+C D  G   L   A      +  + L  GA+V + +  G +AL  +   GH+ +  +L
Sbjct: 939  VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998

Query: 131  LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
            + + ADVNA +    S L  A+  GH+ VV+LL+E GA VDH    G             
Sbjct: 999  IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQG------------- 1045

Query: 191  DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
              TAL  A Q GH  VV++L+E GADPNHA +  G + + +AA  G   + + L + GA+
Sbjct: 1046 -ATALCIAAQEGHIDVVQVLLEHGADPNHADQ-FGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 30/83 (36%), Positives = 50/83 (60%), Gaps = 1/83 (1%)

Query: 314 EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNK 373
           ++ + VN  + +G T L  AA +G L +V LLV R AD++ +D+ HG T L  A   G+ 
Sbjct: 533 DNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDA-HGHTPLTLAARQGHT 591

Query: 374 EIVKYLLNQGADVTLRAKNGYTA 396
           ++V  L+  GA++    ++G+TA
Sbjct: 592 KVVNCLIGCGANINHTDQDGWTA 614



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 30/117 (25%), Positives = 59/117 (50%), Gaps = 5/117 (4%)

Query: 306 QLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALM 365
           Q V ++  +  +HVN  + D  T  ++     +   ++ L++  A V++ DS +G T L 
Sbjct: 494 QEVLQLLVKAGAHVN--SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDS-NGRTLLA 550

Query: 366 QATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVN 422
            A Y G+ ++V  L+++GAD+ +   +G+T   L +      T++V  L      +N
Sbjct: 551 NAAYSGSLDVVNLLVSRGADLEIEDAHGHT--PLTLAARQGHTKVVNCLIGCGANIN 605


>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
           [Homo sapiens]
          Length = 2542

 Score =  148 bits (374), Expect = 2e-35
 Identities = 138/415 (33%), Positives = 188/415 (45%), Gaps = 52/415 (12%)

Query: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 389 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 434

Query: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 435 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 494 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 549

Query: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+   ++ G T
Sbjct: 550 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603



 Score =  132 bits (333), Expect = 1e-30
 Identities = 110/338 (32%), Positives = 161/338 (47%), Gaps = 26/338 (7%)

Query: 69   VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
            V +D   E+ + TAL  A AGGHE LV  L+ R A +  R+  G++ L+ AA  GHV V 
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 128  HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185
             +LLD G D+ AQ+ R   + L++A  GG   VV LLL  GA  +H + S    L L  S
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 186  --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225
                                    L I+ LM A  +GH   V+LL++ G+D N    T  
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 226  WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284
             + L LA   GR  V   L+++ AN +H +    T    A    + ++    LD    V 
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 285  PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344
                   R   +  A   G+++   E+     +H+++ N  G TPL LA+  G   +VQL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 345  LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
            LV+  ADVD  D+    T LM A   G+ ++V+YL+ +
Sbjct: 1344 LVQAGADVDAADN-RKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 81/295 (27%), Positives = 128/295 (43%), Gaps = 61/295 (20%)

Query: 146  SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEA 205
            + LT+A  GGH  +V +L+   A ++H    G               T L+ A   GH  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKG--------------FTPLILAATAGHVG 1102

Query: 206  VVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVA 265
            VV +L++ G D    +     +PL LA   GR  V   L+ +GAN +H +V + T   +A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162

Query: 266  LDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGD 325
                + +++  L                      L  G             + +N   G 
Sbjct: 1163 ASGGYVNIIKIL----------------------LNAG-------------AEINSRTGS 1187

Query: 326  --GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQG 383
              G +PLMLAA+ G +  V+LL++  +D++ Q   +  TAL  A + G  E+V  LL++ 
Sbjct: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247

Query: 384  ADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSK 438
            A+V  RAK G T   L+   +    E+ R+L         DKG   + PP+P S+
Sbjct: 1248 ANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAPPVPSSR 1292



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 75/234 (32%), Positives = 104/234 (44%), Gaps = 19/234 (8%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
           L+ A  +G  E    LL  GA   A+     E     A        A      GA + + 
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
           CS     T L  A+  GH  LV++LL  GA+V++    G +AL  A   GH  VA +LL 
Sbjct: 535 CS-----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
            GAD+  ++  G + L  A+R GHL  V+ L+  GA V+    +              D 
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-------------DH 636

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246
           T +  A   GH AVV LL+  GADP H  +  G + L+ AA  G   V   L++
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTNVVSYLLD 689



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 57/156 (36%), Positives = 73/156 (46%), Gaps = 7/156 (4%)

Query: 13   LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69
            L  AC QG  E    LL+  A     A+ G  P   A   G    G      GA V AP 
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1286

Query: 70   PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
            PV  S +   TAL  AA  GH      L+ RGA ++ RN  G + L  A+  GH  V  L
Sbjct: 1287 PVPSSRD---TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 130  LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
            L+  GADV+A +    + L  A R GH+ VV+ L++
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 51/275 (18%)

Query: 148 LTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVV 207
           L  A   G +  V+ LL+ G  V+ H   GE L              L  A   G+  + 
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESL--------------LCLACSAGYYELA 254

Query: 208 RLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALD 267
           ++L+   A+          +PLM A+  G L + + L+   A+ +  S    TA      
Sbjct: 255 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA------ 308

Query: 268 CKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGA 327
                                       + +A   G   +VK + +E  +++   N +G 
Sbjct: 309 ----------------------------LTYACAGGFVDIVKVLLNEG-ANIEDHNENGH 339

Query: 328 TPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVT 387
           TPLM AA  G + + ++L++  A ++   +    +AL  A Y G+ ++V++LL  GAD  
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 388 LRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVN 422
            +    +TA  L+    D   E+ RLL     QVN
Sbjct: 400 HKTDEMHTA--LMEACMDGHVEVARLLLDSGAQVN 432



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 41/127 (32%), Positives = 58/127 (45%), Gaps = 6/127 (4%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPA-GAEVAGPGAAAAGAVGAPVPV 71
           L  AC+ G T+ A  LL+ GA    +   E E G  P   A  AG        +     V
Sbjct: 572 LTYACENGHTDVADVLLQAGA----DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 627

Query: 72  D-CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +  +    +T +  A AGGH  +V  LL  GA    R   G + L++AA+ GH +V   L
Sbjct: 628 NRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687

Query: 131 LDHGADV 137
           LD+  +V
Sbjct: 688 LDYPNNV 694


>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
          Length = 2617

 Score =  148 bits (374), Expect = 2e-35
 Identities = 138/415 (33%), Positives = 188/415 (45%), Gaps = 52/415 (12%)

Query: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 389 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 434

Query: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 435 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 494 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 549

Query: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+   ++ G T
Sbjct: 550 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 603



 Score =  132 bits (333), Expect = 1e-30
 Identities = 110/338 (32%), Positives = 161/338 (47%), Gaps = 26/338 (7%)

Query: 69   VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
            V +D   E+ + TAL  A AGGHE LV  L+ R A +  R+  G++ L+ AA  GHV V 
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104

Query: 128  HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185
             +LLD G D+ AQ+ R   + L++A  GG   VV LLL  GA  +H + S    L L  S
Sbjct: 1105 EILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAAS 1164

Query: 186  --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225
                                    L I+ LM A  +GH   V+LL++ G+D N    T  
Sbjct: 1165 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNR 1224

Query: 226  WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284
             + L LA   GR  V   L+++ AN +H +    T    A    + ++    LD    V 
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284

Query: 285  PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344
                   R   +  A   G+++   E+     +H+++ N  G TPL LA+  G   +VQL
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFC-ELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 345  LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
            LV+  ADVD  D+    T LM A   G+ ++V+YL+ +
Sbjct: 1344 LVQAGADVDAADN-RKITPLMSAFRKGHVKVVQYLVKE 1380



 Score = 91.3 bits (225), Expect = 4e-18
 Identities = 81/295 (27%), Positives = 128/295 (43%), Gaps = 61/295 (20%)

Query: 146  SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEA 205
            + LT+A  GGH  +V +L+   A ++H    G               T L+ A   GH  
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKG--------------FTPLILAATAGHVG 1102

Query: 206  VVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVA 265
            VV +L++ G D    +     +PL LA   GR  V   L+ +GAN +H +V + T   +A
Sbjct: 1103 VVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLA 1162

Query: 266  LDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGD 325
                + +++  L                      L  G             + +N   G 
Sbjct: 1163 ASGGYVNIIKIL----------------------LNAG-------------AEINSRTGS 1187

Query: 326  --GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQG 383
              G +PLMLAA+ G +  V+LL++  +D++ Q   +  TAL  A + G  E+V  LL++ 
Sbjct: 1188 KLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRK 1247

Query: 384  ADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQPPLPHSK 438
            A+V  RAK G T   L+   +    E+ R+L         DKG   + PP+P S+
Sbjct: 1248 ANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAPPVPSSR 1292



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 75/234 (32%), Positives = 104/234 (44%), Gaps = 19/234 (8%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
           L+ A  +G  E    LL  GA   A+     E     A        A      GA + + 
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELG 534

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
           CS     T L  A+  GH  LV++LL  GA+V++    G +AL  A   GH  VA +LL 
Sbjct: 535 CS-----TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQ 589

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
            GAD+  ++  G + L  A+R GHL  V+ L+  GA V+    +              D 
Sbjct: 590 AGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANN-------------DH 636

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246
           T +  A   GH AVV LL+  GADP H  +  G + L+ AA  G   V   L++
Sbjct: 637 TVVSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTNVVSYLLD 689



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 57/156 (36%), Positives = 73/156 (46%), Gaps = 7/156 (4%)

Query: 13   LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69
            L  AC QG  E    LL+  A     A+ G  P   A   G    G      GA V AP 
Sbjct: 1228 LTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1286

Query: 70   PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
            PV  S +   TAL  AA  GH      L+ RGA ++ RN  G + L  A+  GH  V  L
Sbjct: 1287 PVPSSRD---TALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQL 1343

Query: 130  LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
            L+  GADV+A +    + L  A R GH+ VV+ L++
Sbjct: 1344 LVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 66/275 (24%), Positives = 111/275 (40%), Gaps = 51/275 (18%)

Query: 148 LTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVV 207
           L  A   G +  V+ LL+ G  V+ H   GE L              L  A   G+  + 
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESL--------------LCLACSAGYYELA 254

Query: 208 RLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALD 267
           ++L+   A+          +PLM A+  G L + + L+   A+ +  S    TA      
Sbjct: 255 QVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTA------ 308

Query: 268 CKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGA 327
                                       + +A   G   +VK + +E  +++   N +G 
Sbjct: 309 ----------------------------LTYACAGGFVDIVKVLLNEG-ANIEDHNENGH 339

Query: 328 TPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVT 387
           TPLM AA  G + + ++L++  A ++   +    +AL  A Y G+ ++V++LL  GAD  
Sbjct: 340 TPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

Query: 388 LRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVN 422
            +    +TA  L+    D   E+ RLL     QVN
Sbjct: 400 HKTDEMHTA--LMEACMDGHVEVARLLLDSGAQVN 432



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 41/127 (32%), Positives = 58/127 (45%), Gaps = 6/127 (4%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPA-GAEVAGPGAAAAGAVGAPVPV 71
           L  AC+ G T+ A  LL+ GA    +   E E G  P   A  AG        +     V
Sbjct: 572 LTYACENGHTDVADVLLQAGA----DLEHESEGGRTPLMKAARAGHLCTVQFLISKGANV 627

Query: 72  D-CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +  +    +T +  A AGGH  +V  LL  GA    R   G + L++AA+ GH +V   L
Sbjct: 628 NRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYL 687

Query: 131 LDHGADV 137
           LD+  +V
Sbjct: 688 LDYPNNV 694


>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
           [Homo sapiens]
          Length = 627

 Score =  148 bits (373), Expect = 2e-35
 Identities = 144/446 (32%), Positives = 198/446 (44%), Gaps = 61/446 (13%)

Query: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268

Query: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328

Query: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388

Query: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 389 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 434

Query: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 435 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493

Query: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 494 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 549

Query: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLV 400
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+  +        D+ 
Sbjct: 550 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLDKQE-------DMK 601

Query: 401 MLLN--DPDTELVRLLASVCMQVNKD 424
            +L   DP    VR+    C  + K+
Sbjct: 602 TILEGIDPAKHQVRVAFDACKLLRKE 627


>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
           [Homo sapiens]
          Length = 616

 Score =  148 bits (373), Expect = 2e-35
 Identities = 144/446 (32%), Positives = 198/446 (44%), Gaps = 61/446 (13%)

Query: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
           L  AC  GD    R+LL+ G +  E  E G      A  AG            A V   G
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257

Query: 59  ---------AAAAGAVGAPVP--------VDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
                    AA++G     V         V+     GNTAL +A AGG   +V+ LL  G
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317

Query: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNA-QNRLGASVLTVASRGGHLGVV 160
           A++   N  G + LM+AA  GHV VA +LLDHGA +N   N    S LT+A   GHL +V
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377

Query: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 378 RFLLEAGA--DQEHKTDEM------------HTALMEACMDGHVEVARLLLDSGAQVNMP 423

Query: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPL 280
           A +   SPL LAA  G + +A  L+E+GAN + ++    T    A    H ++V  L   
Sbjct: 424 ADSFE-SPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482

Query: 281 TTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLA 340
                   EE +   +  A   G F  V +   +  + + L     +TPLM A+  G L 
Sbjct: 483 GANINAQTEETQETALTLAC-CGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHLE 538

Query: 341 LVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLV 400
           LV+ L+   A+V    +  G TAL  A  +G+ ++   LL  GAD+  +        D+ 
Sbjct: 539 LVKYLLASGANVHATTAT-GDTALTYACENGHTDVADVLLQAGADLDKQE-------DMK 590

Query: 401 MLLN--DPDTELVRLLASVCMQVNKD 424
            +L   DP    VR+    C  + K+
Sbjct: 591 TILEGIDPAKHQVRVAFDACKLLRKE 616


>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
          Length = 2603

 Score =  145 bits (367), Expect = 1e-34
 Identities = 116/338 (34%), Positives = 169/338 (50%), Gaps = 26/338 (7%)

Query: 69   VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
            + +D   E+ + TAL  A AGGHE LV+ LL RGAS+  R+  G++ L+ AA  GHV V 
Sbjct: 1073 IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 1132

Query: 128  HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185
             +LLD+GAD+ AQ+ R   + L++A  GG   VV+LLL  GA  +H + S    L L  S
Sbjct: 1133 EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 1192

Query: 186  --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225
                                    L I+ LM A  +GH A V+LL++ G+D N    T  
Sbjct: 1193 GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1252

Query: 226  WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284
             + L LA   GR  V   L+++ AN +H +    T    A    + ++    LD    V 
Sbjct: 1253 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1312

Query: 285  PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344
                   R   +  A   G+++   E+     +H+++ N  G TPL LAA  G L +VQL
Sbjct: 1313 APPVPSSRDTALTIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 345  LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
            LV+  ADVD  D+    T LM A   G+ ++V+YL+ +
Sbjct: 1372 LVQAGADVDAADN-RKITPLMAAFRKGHVKVVRYLVKE 1408



 Score =  142 bits (359), Expect = 1e-33
 Identities = 142/477 (29%), Positives = 196/477 (41%), Gaps = 109/477 (22%)

Query: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAG------------AEVAGPG 58
           L  AC +GD    R+LL  G +  E  E G      A  AG            A V   G
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297

Query: 59  ---------AAAAGA--------VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRG 101
                    AAA G         +     V+     GNTAL +A AGG+  +V+ LL  G
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357

Query: 102 ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQ-NRLGASVLTVASRGGHLGVV 160
           AS+   N  G + LM+A   GHV VA LLL++GA +N   N    S LT+A   GHL +V
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417

Query: 161 KLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHA 220
           + LLEAGA  D  H + E              TALM A   GH  V RLL++ GA  N  
Sbjct: 418 RFLLEAGA--DQEHKTDEMH------------TALMEACMDGHVEVARLLLDSGAQVNMP 463

Query: 221 ARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYL-DP 279
           A +   SPL LAA  G + +A  L+E+GA+ + ++    T    A    H ++V  L   
Sbjct: 464 ADSFE-SPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522

Query: 280 LTTVRPKTDEEKRRP-----------------------------DIFHALKMGNFQLVKE 310
              +  +T+E +                                 +  A + G+ +LVK 
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKY 582

Query: 311 IADEDPS-HVNLVNGD-------------------------------GATPLMLAAVTGQ 338
           +     + H     GD                               G TPLM AA  G 
Sbjct: 583 LLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGH 642

Query: 339 LALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           +  VQ L+ + A+V++  + +  T L  A   G+  +V+ LL  GAD T R K+G T
Sbjct: 643 VCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699



 Score =  101 bits (251), Expect = 3e-21
 Identities = 89/306 (29%), Positives = 137/306 (44%), Gaps = 62/306 (20%)

Query: 136  DVNAQNRLGA-SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITA 194
            D++AQ      + LT+A  GGH  +V+ LLE GA ++H    G               T 
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--------------FTP 1119

Query: 195  LMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHL 254
            L+ A   GH  VV +L++ GAD    +     +PL LA   GR  V + L+ +GAN +H 
Sbjct: 1120 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 1179

Query: 255  SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADE 314
            +V + T   +A    + +++  L                      L  G           
Sbjct: 1180 NVSDYTPLSLAASGGYVNIIKIL----------------------LNAG----------- 1206

Query: 315  DPSHVNLVNGD--GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGN 372
              + +N   G   G +PLMLAA+ G  A V+LL++  +D++ Q   +  TAL  A + G 
Sbjct: 1207 --AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1264

Query: 373  KEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQP 432
             E+V  LL++ A+V  RAK G T   L+   +    E+ R+L         DKG   + P
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAP 1314

Query: 433  PLPHSK 438
            P+P S+
Sbjct: 1315 PVPSSR 1320



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 76/234 (32%), Positives = 104/234 (44%), Gaps = 19/234 (8%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
           L+ A  +G  E    LL  GA   A+     E     A        A      GA + + 
Sbjct: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
           CS     T L  AA  GH  LV++LL  GA+V++    G +AL  A   GH  VA +LL 
Sbjct: 564 CS-----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
            GAD+  ++  G + L  A+R GH+  V+ L+  GA V+    +              D 
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN-------------DH 665

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246
           T L  A   GH AVV LL+  GADP H  +  G + L+ AA  G   V   L++
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTSVVCYLLD 718



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 59/156 (37%), Positives = 75/156 (48%), Gaps = 7/156 (4%)

Query: 13   LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69
            L  AC QG TE    LL+  A     A+ G  P   A   G    G      GA V AP 
Sbjct: 1256 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1314

Query: 70   PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
            PV  S +   TAL  AA  GH      L+ RGA ++ RN  G + L  AA  GH+ V  L
Sbjct: 1315 PVPSSRD---TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1371

Query: 130  LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
            L+  GADV+A +    + L  A R GH+ VV+ L++
Sbjct: 1372 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 42/123 (34%), Positives = 55/123 (44%), Gaps = 6/123 (4%)

Query: 13  LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
           L  AC+ G T+ A  LL+ GA     +E G  P   A  AG         + GA      
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            +      +T L  A AGGH  +V  LL  GA    R   G + L++AA+ GH SV   L
Sbjct: 661 ANND----HTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYL 716

Query: 131 LDH 133
           LD+
Sbjct: 717 LDY 719



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 49/165 (29%), Positives = 68/165 (41%), Gaps = 34/165 (20%)

Query: 615  FPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKK 674
            FP  P SPA + NS      PH         V RH  +  N SG  +++           
Sbjct: 1927 FPVRPLSPARATNSPK----PHM--------VPRHSNQ--NSSGSQVNS----------- 1961

Query: 675  AAGLLEQKPSHR-SSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTT--SK 731
             AG L   P+   SS     PG+S +  P+SP+         ++TS    +  +TT  + 
Sbjct: 1962 -AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNN 2020

Query: 732  STSPT--LTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITD 774
            +T+PT    P P+ K H   SS SS S   Q    GG S  +  D
Sbjct: 2021 NTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ---PGGVSRNSPLD 2062



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 71/328 (21%), Positives = 115/328 (35%), Gaps = 44/328 (13%)

Query: 498  TMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTMLRNGAPLTRLPSDKLKAV 557
            ++ ++P   TS SA     P T  NG  S+   +    +T +  + A  T + +    A 
Sbjct: 1964 SLTSSPTTTTSSSA--STVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTT---AS 2018

Query: 558  IPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVR------ 611
                 P ++     + +     +  + P   A P   SR  P+  G      V       
Sbjct: 2019 NNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQE 2078

Query: 612  ----PVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQ 667
                PV   +  R P SS++SG+   S HS+       VS+     L +S      V   
Sbjct: 2079 AGSPPVVETTNTRPPNSSSSSGS--SSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 2136

Query: 668  IAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSE--LPASPAGGSAPVGKKLETS--KRPP 723
            +              P   SS     P ++P    +P +P G   P   K+ET   + PP
Sbjct: 2137 VP-------------PLATSSAPVAVPSTAPVTYPMPQTPMGCPQPT-PKMETPAIRPPP 2182

Query: 724  SGTSTTSK-------STSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDED 776
             GT+   K       S+   L+ +   + H+  SSV   S+   S  S   +S    ++ 
Sbjct: 2183 HGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPST--LSTQSACQNSVHPANKP 2240

Query: 777  ELTGILKKLSLEKYQPIFEEQEVDMEAF 804
                    L    +  +FE       AF
Sbjct: 2241 IAPNFSAPLPFGPFSTLFENSPTSAHAF 2268


>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
          Length = 2352

 Score =  145 bits (367), Expect = 1e-34
 Identities = 116/338 (34%), Positives = 169/338 (50%), Gaps = 26/338 (7%)

Query: 69   VPVDCSDEAGN-TALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
            + +D   E+ + TAL  A AGGHE LV+ LL RGAS+  R+  G++ L+ AA  GHV V 
Sbjct: 822  IDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVV 881

Query: 128  HLLLDHGADVNAQN-RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGS 185
             +LLD+GAD+ AQ+ R   + L++A  GG   VV+LLL  GA  +H + S    L L  S
Sbjct: 882  EILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAAS 941

Query: 186  --------------------RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVG 225
                                    L I+ LM A  +GH A V+LL++ G+D N    T  
Sbjct: 942  GGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNR 1001

Query: 226  WSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVR 284
             + L LA   GR  V   L+++ AN +H +    T    A    + ++    LD    V 
Sbjct: 1002 NTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1061

Query: 285  PKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQL 344
                   R   +  A   G+++   E+     +H+++ N  G TPL LAA  G L +VQL
Sbjct: 1062 APPVPSSRDTALTIAADKGHYKFC-ELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120

Query: 345  LVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQ 382
            LV+  ADVD  D+    T LM A   G+ ++V+YL+ +
Sbjct: 1121 LVQAGADVDAADN-RKITPLMAAFRKGHVKVVRYLVKE 1157



 Score =  125 bits (313), Expect = 2e-28
 Identities = 122/417 (29%), Positives = 183/417 (43%), Gaps = 25/417 (5%)

Query: 13  LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
           L  AC +GD    R+LL  G +  E  E G      A  AG       A    A+ A V 
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYEL---AQVLLAMHANVE 294

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            D   +   T L  AA GGH  +V+ LL   A VN+++  G +AL  A   G+V V  +L
Sbjct: 295 -DRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L+ GA +   N  G + L  A   GH+ V +LLLE GA ++ H    ++           
Sbjct: 354 LESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKE----------- 402

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
             +AL  A   GH  +VR L+E GAD  H    +  + LM A + G + VA+ L++ GA 
Sbjct: 403 --SALTLACYKGHLEMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQ 459

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKE 310
            +  +   ++   +A    H +L   L        + ++E   P +  A + G+ ++V  
Sbjct: 460 VNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTP-LMEAAREGHEEMVAL 518

Query: 311 IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYH 370
           +  +  +          T L LA   G L +   L++  AD++   S    T LM+A   
Sbjct: 519 LLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS----TPLMEAAQE 574

Query: 371 GNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGR 427
           G+ E+VKYLL  GA+V      G TA          D   V L A   ++   + GR
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGR 631



 Score =  102 bits (253), Expect = 2e-21
 Identities = 108/388 (27%), Positives = 163/388 (42%), Gaps = 29/388 (7%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
           L+ A  +G  E    LL  GA   A+     E     A        A      GA + + 
Sbjct: 504 LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELG 563

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
           CS     T L  AA  GH  LV++LL  GA+V++    G +AL  A   GH  VA +LL 
Sbjct: 564 CS-----TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQ 618

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
            GAD+  ++  G + L  A+R GH+  V+ L+  GA V+    +              D 
Sbjct: 619 AGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANN-------------DH 665

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD 252
           T L  A   GH AVV LL+  GADP H  +  G + L+ AA  G   V   L++   N  
Sbjct: 666 TVLSLACAGGHLAVVELLLAHGADPTHRLKD-GSTMLIEAAKGGHTSVVCYLLDYPNNLL 724

Query: 253 HLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIA 312
                + T         +R     +  L  V P  + +K   ++   L + N  +    +
Sbjct: 725 SAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRAS 784

Query: 313 --DEDPSH---VNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQA 367
                P+H    ++      TP  + + +  L +   +     D+D Q   +  TAL  A
Sbjct: 785 AMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAI-----DIDAQTESNHDTALTLA 839

Query: 368 TYHGNKEIVKYLLNQGADVTLRAKNGYT 395
              G++E+V+ LL +GA +  R K G+T
Sbjct: 840 CAGGHEELVQTLLERGASIEHRDKKGFT 867



 Score =  101 bits (251), Expect = 3e-21
 Identities = 89/306 (29%), Positives = 137/306 (44%), Gaps = 62/306 (20%)

Query: 136  DVNAQNRLGA-SVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITA 194
            D++AQ      + LT+A  GGH  +V+ LLE GA ++H    G               T 
Sbjct: 823  DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKG--------------FTP 868

Query: 195  LMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHL 254
            L+ A   GH  VV +L++ GAD    +     +PL LA   GR  V + L+ +GAN +H 
Sbjct: 869  LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 928

Query: 255  SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADE 314
            +V + T   +A    + +++  L                      L  G           
Sbjct: 929  NVSDYTPLSLAASGGYVNIIKIL----------------------LNAG----------- 955

Query: 315  DPSHVNLVNGD--GATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGN 372
              + +N   G   G +PLMLAA+ G  A V+LL++  +D++ Q   +  TAL  A + G 
Sbjct: 956  --AEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGR 1013

Query: 373  KEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKGRPSHQP 432
             E+V  LL++ A+V  RAK G T   L+   +    E+ R+L         DKG   + P
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLT--PLMEAASGGYAEVGRVLL--------DKGADVNAP 1063

Query: 433  PLPHSK 438
            P+P S+
Sbjct: 1064 PVPSSR 1069



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 59/156 (37%), Positives = 75/156 (48%), Gaps = 7/156 (4%)

Query: 13   LLRACDQGDTETARRLLEPGA--AEPAERGAEPEAGAEPAGAEVAGPGAAAAGA-VGAPV 69
            L  AC QG TE    LL+  A     A+ G  P   A   G    G      GA V AP 
Sbjct: 1005 LTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP- 1063

Query: 70   PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
            PV  S +   TAL  AA  GH      L+ RGA ++ RN  G + L  AA  GH+ V  L
Sbjct: 1064 PVPSSRD---TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQL 1120

Query: 130  LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
            L+  GADV+A +    + L  A R GH+ VV+ L++
Sbjct: 1121 LVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 49/165 (29%), Positives = 68/165 (41%), Gaps = 34/165 (20%)

Query: 615  FPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQIAAQRKK 674
            FP  P SPA + NS      PH         V RH  +  N SG  +++           
Sbjct: 1676 FPVRPLSPARATNSPK----PHM--------VPRHSNQ--NSSGSQVNS----------- 1710

Query: 675  AAGLLEQKPSHR-SSPVGPAPGSSPSELPASPAGGSAPVGKKLETSKRPPSGTSTT--SK 731
             AG L   P+   SS     PG+S +  P+SP+         ++TS    +  +TT  + 
Sbjct: 1711 -AGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTTASNN 1769

Query: 732  STSPT--LTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITD 774
            +T+PT    P P+ K H   SS SS S   Q    GG S  +  D
Sbjct: 1770 NTAPTNATYPMPTAKEHYPVSSPSSPSPPAQ---PGGVSRNSPLD 1811



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 71/328 (21%), Positives = 115/328 (35%), Gaps = 44/328 (13%)

Query: 498  TMRAAPQDKTSRSALPDAAPVTKDNGPGSTRGEKEDTLLTTMLRNGAPLTRLPSDKLKAV 557
            ++ ++P   TS SA     P T  NG  S+   +    +T +  + A  T + +    A 
Sbjct: 1713 SLTSSPTTTTSSSA--STVPGTSTNGSPSSPSVRRQLFVTVVKTSNATTTTVTTT---AS 1767

Query: 558  IPPFLPPSSFELWSSDRSRTRHNGKADPMKTALPQRASRGHPVGGGGTDTTPVR------ 611
                 P ++     + +     +  + P   A P   SR  P+  G      V       
Sbjct: 1768 NNNTAPTNATYPMPTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQE 1827

Query: 612  ----PVKFPSLPRSPASSANSGNFNHSPHSSGGSSGVGVSRHGGELLNRSGGSIDNVLSQ 667
                PV   +  R P SS++SG+   S HS+       VS+     L +S      V   
Sbjct: 1828 AGSPPVVETTNTRPPNSSSSSGS--SSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMT 1885

Query: 668  IAAQRKKAAGLLEQKPSHRSSPVGPAPGSSPSE--LPASPAGGSAPVGKKLETS--KRPP 723
            +              P   SS     P ++P    +P +P G   P   K+ET   + PP
Sbjct: 1886 VP-------------PLATSSAPVAVPSTAPVTYPMPQTPMGCPQPT-PKMETPAIRPPP 1931

Query: 724  SGTSTTSK-------STSPTLTPSPSPKGHTAESSVSSSSSHRQSKSSGGSSSGTITDED 776
             GT+   K       S+   L+ +   + H+  SSV   S+   S  S   +S    ++ 
Sbjct: 1932 HGTTAPHKNSASVQNSSVAVLSVNHIKRPHSVPSSVQLPST--LSTQSACQNSVHPANKP 1989

Query: 777  ELTGILKKLSLEKYQPIFEEQEVDMEAF 804
                    L    +  +FE       AF
Sbjct: 1990 IAPNFSAPLPFGPFSTLFENSPTSAHAF 2017


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  129 bits (325), Expect = 9e-30
 Identities = 106/364 (29%), Positives = 178/364 (48%), Gaps = 27/364 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+ + + G T L  A+  G+  +VR LL RGA + ++     + L  AAR GHV ++ +L
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-----------------HH 173
           LDHGA + A+ + G S + +A++G HL  V+LLL+  A +D                 HH
Sbjct: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 384

Query: 174 HPSGEQLGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLML 231
             +   L  G   +       T L  A +  H  V+ LL++ GA  + A    G +PL +
Sbjct: 385 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID-AVTESGLTPLHV 443

Query: 232 AALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEE 290
           A+  G L + + L+++GA+P+  +V  +T   +A    H ++  Y L     V  K  ++
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 503

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHA 350
             +  +  A ++G+  +VK +  E+ ++ NL    G TPL +AA  G +  V  L+E+ A
Sbjct: 504 --QTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 560

Query: 351 DVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
                 +  G+T L  A  +G   + + LL + A      KNG T   + +  N+ D  +
Sbjct: 561 S-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD--I 617

Query: 411 VRLL 414
           V+LL
Sbjct: 618 VKLL 621



 Score =  121 bits (303), Expect = 3e-27
 Identities = 115/380 (30%), Positives = 169/380 (44%), Gaps = 59/380 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D   E+G T L  A+  GH P+V+ LL+RGAS N  N    + L  AAR GH  VA  L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L + A VNA+ +   + L  A+R GH  +VKLLLE  A  +    +G             
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH------------ 537

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTV-GWSPLMLAALTGRLGVAQQLVEKGA 249
             T L  A + GH   V  L+E   + + A  T  G++PL +AA  G++ VA+ L+E+ A
Sbjct: 538 --TPLHIAAREGHVETVLALLE--KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 593

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYL---------------DPLTTVRPKTDEEKRRP 294
           +P+       T   VA+   + D+V  L                PL     +   E  R 
Sbjct: 594 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 653

Query: 295 DIFHALKMGNFQLVKEIADEDPSHV--------------------NLVNGDGATPLMLAA 334
                L+ G     + +    P H+                    NL N  G TPL L A
Sbjct: 654 ----LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 709

Query: 335 VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY 394
             G + +  +L++    VD    + G+T L  A+++GN ++VK+LL   ADV  + K GY
Sbjct: 710 QEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768

Query: 395 TAFDLVMLLNDPDTELVRLL 414
           +   L        T++V LL
Sbjct: 769 S--PLHQAAQQGHTDIVTLL 786



 Score =  115 bits (287), Expect = 2e-25
 Identities = 98/335 (29%), Positives = 155/335 (46%), Gaps = 18/335 (5%)

Query: 70  PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
           P+    + G + +  AA G H   VR LL+  A ++       + L  AA  GH  VA +
Sbjct: 330 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 389

Query: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
           LLD GA  N++   G + L +A +  H+ V++LLL+ GA +D    SG            
Sbjct: 390 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG------------ 437

Query: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
             +T L  A   GH  +V+ L++ GA PN +   V  +PL +AA  G   VA+ L++  A
Sbjct: 438 --LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKA 494

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
             +  +  ++T    A    H ++V  L       P          +  A + G+ + V 
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVL 553

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
            + +++ S   +    G TPL +AA  G++ + +LL+ER A  +     +G T L  A +
Sbjct: 554 ALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVH 611

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           H N +IVK LL +G      A NGYT   +    N
Sbjct: 612 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 646



 Score =  105 bits (262), Expect = 2e-22
 Identities = 91/335 (27%), Positives = 155/335 (46%), Gaps = 24/335 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++ + + GNTAL  AA  G + +VR L+  GA+VN+++  G++ L  AA+  H+ V   L
Sbjct: 104 LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 163

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L++GA+ N     G + L VA + GH  VV  L+  G                      +
Sbjct: 164 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT------------------KGKV 205

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
            + AL  A ++       +L++   +P+  ++T G++PL +AA    L VAQ L+ +GA+
Sbjct: 206 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGAS 264

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
            +       T   +A    +  +V   LD    +  KT +E       H         + 
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP---LHCAARNGHVRIS 321

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
           EI  +  + +     +G +P+ +AA    L  V+LL++  A++D     H  T L  A +
Sbjct: 322 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAH 380

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
            G+  + K LL++GA    RA NG+T   +    N
Sbjct: 381 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 415



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 105/411 (25%), Positives = 164/411 (39%), Gaps = 54/411 (13%)

Query: 52  AEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
           A +AG        V     V+   + G T L  AA   H  +V+FLL  GA+ N     G
Sbjct: 118 AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177

Query: 112 WSALMQAARFGHVSVAHLLLDHG---------------------ADVNAQN--------R 142
           ++ L  A + GH +V   L+++G                     A V  QN        +
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237

Query: 143 LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDEPL----------- 190
            G + L +A+   +L V +LLL  GA V+    +G   L +   R   +           
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297

Query: 191 -------DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQ 243
                  ++T L  A ++GH  +  +L++ GA P  A    G SP+ +AA    L   + 
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVRL 356

Query: 244 LVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMG 303
           L++  A  D +++   T   VA  C H  +   L  L                 H     
Sbjct: 357 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL--LDKGAKPNSRALNGFTPLHIACKK 414

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
           N   V E+  +  + ++ V   G TPL +A+  G L +V+ L++R A      +V   T 
Sbjct: 415 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETP 473

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
           L  A   G+ E+ KYLL   A V  +AK+  T       +    T +V+LL
Sbjct: 474 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG--HTNMVKLL 522



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 87/291 (29%), Positives = 127/291 (43%), Gaps = 28/291 (9%)

Query: 77  AGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGAD 136
           AG+T L  AA  GH   V  LL + AS       G++ L  AA++G V VA LLL+  A 
Sbjct: 535 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 594

Query: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE------------------ 178
            NA  + G + L VA    +L +VKLLL  G     H P+                    
Sbjct: 595 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--SPHSPAWNGYTPLHIAAKQNQVEVAR 652

Query: 179 ---QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALT 235
              Q G   + +    +T L  A Q GH  +V LL+   A+ N   ++ G +PL L A  
Sbjct: 653 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS-GLTPLHLVAQE 711

Query: 236 GRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRP 294
           G + VA  L++ G   D  + +  T   VA    +  LV + L     V  KT  +    
Sbjct: 712 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT--KLGYS 769

Query: 295 DIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLL 345
            +  A + G+  +V  +     S  N V+ DG TPL +A   G +++  +L
Sbjct: 770 PLHQAAQQGHTDIVTLLLKNGAS-PNEVSSDGTTPLAIAKRLGYISVTDVL 819



 Score = 84.0 bits (206), Expect = 6e-16
 Identities = 85/273 (31%), Positives = 120/273 (43%), Gaps = 38/273 (13%)

Query: 2   GEGGLPPAFQLLLRACDQGDTETARRLLEPGAA--EPAERGAEP-EAGAEPAGAEVAGPG 58
           G+ GL P    L  A    + +  + LL  G +   PA  G  P    A+    EVA   
Sbjct: 599 GKNGLTP----LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 654

Query: 59  AAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQA 118
               G+  A          G T L  AA  GH  +V  LL + A+ N  N  G + L   
Sbjct: 655 LQYGGSANA------ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708

Query: 119 ARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE 178
           A+ GHV VA +L+ HG  V+A  R+G + L VAS  G++ +VK LL+  A V        
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-------- 760

Query: 179 QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRL 238
                 +    L  + L  A Q GH  +V LL++ GA PN  + + G +PL +A   G +
Sbjct: 761 ------NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS-SDGTTPLAIAKRLGYI 813

Query: 239 GVAQQLVEKGANPDHLSVLEKTAFEVALDCKHR 271
            V   L           V ++T+F +  D KHR
Sbjct: 814 SVTDVL---------KVVTDETSFVLVSD-KHR 836



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 60/204 (29%), Positives = 95/204 (46%), Gaps = 15/204 (7%)

Query: 78  GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
           G T L  AA      + R LL+ G S N+ +  G + L  AA+ GH  +  LLL   A+ 
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694

Query: 138 NAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
           N  N+ G + L + ++ GH+ V  +L++ G  VD     G               T L  
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMG--------------YTPLHV 740

Query: 198 AIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVL 257
           A  +G+  +V+ L++  AD N A   +G+SPL  AA  G   +   L++ GA+P+ +S  
Sbjct: 741 ASHYGNIKLVKFLLQHQADVN-AKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSD 799

Query: 258 EKTAFEVALDCKHRDLVDYLDPLT 281
             T   +A    +  + D L  +T
Sbjct: 800 GTTPLAIAKRLGYISVTDVLKVVT 823



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 46/131 (35%), Positives = 71/131 (54%), Gaps = 11/131 (8%)

Query: 69  VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAH 128
           V VD +   G T L  A+  G+  LV+FLL+  A VN++   G+S L QAA+ GH  +  
Sbjct: 725 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVT 784

Query: 129 LLLDHGADVNAQNRLGASVLTVASRGGHLG---VVKLLLEAGAFV---DHHHPSGEQLGL 182
           LLL +GA  N  +  G + L +A R G++    V+K++ +  +FV   D H  S  +   
Sbjct: 785 LLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKHRMSFPE--- 841

Query: 183 GGSRDEPLDIT 193
             + DE LD++
Sbjct: 842 --TVDEILDVS 850


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  129 bits (325), Expect = 9e-30
 Identities = 106/364 (29%), Positives = 178/364 (48%), Gaps = 27/364 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+ + + G T L  A+  G+  +VR LL RGA + ++     + L  AAR GHV ++ +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-----------------HH 173
           LDHGA + A+ + G S + +A++G HL  V+LLL+  A +D                 HH
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 174 HPSGEQLGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLML 231
             +   L  G   +       T L  A +  H  V+ LL++ GA  + A    G +PL +
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID-AVTESGLTPLHV 410

Query: 232 AALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEE 290
           A+  G L + + L+++GA+P+  +V  +T   +A    H ++  Y L     V  K  ++
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHA 350
             +  +  A ++G+  +VK +  E+ ++ NL    G TPL +AA  G +  V  L+E+ A
Sbjct: 471 --QTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 351 DVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
                 +  G+T L  A  +G   + + LL + A      KNG T   + +  N+ D  +
Sbjct: 528 S-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD--I 584

Query: 411 VRLL 414
           V+LL
Sbjct: 585 VKLL 588



 Score =  121 bits (303), Expect = 3e-27
 Identities = 115/380 (30%), Positives = 169/380 (44%), Gaps = 59/380 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D   E+G T L  A+  GH P+V+ LL+RGAS N  N    + L  AAR GH  VA  L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L + A VNA+ +   + L  A+R GH  +VKLLLE  A  +    +G             
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH------------ 504

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTV-GWSPLMLAALTGRLGVAQQLVEKGA 249
             T L  A + GH   V  L+E   + + A  T  G++PL +AA  G++ VA+ L+E+ A
Sbjct: 505 --TPLHIAAREGHVETVLALLE--KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYL---------------DPLTTVRPKTDEEKRRP 294
           +P+       T   VA+   + D+V  L                PL     +   E  R 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 295 DIFHALKMGNFQLVKEIADEDPSHV--------------------NLVNGDGATPLMLAA 334
                L+ G     + +    P H+                    NL N  G TPL L A
Sbjct: 621 ----LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676

Query: 335 VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY 394
             G + +  +L++    VD    + G+T L  A+++GN ++VK+LL   ADV  + K GY
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 395 TAFDLVMLLNDPDTELVRLL 414
           +   L        T++V LL
Sbjct: 736 S--PLHQAAQQGHTDIVTLL 753



 Score =  115 bits (287), Expect = 2e-25
 Identities = 98/335 (29%), Positives = 155/335 (46%), Gaps = 18/335 (5%)

Query: 70  PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
           P+    + G + +  AA G H   VR LL+  A ++       + L  AA  GH  VA +
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
           LLD GA  N++   G + L +A +  H+ V++LLL+ GA +D    SG            
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG------------ 404

Query: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
             +T L  A   GH  +V+ L++ GA PN +   V  +PL +AA  G   VA+ L++  A
Sbjct: 405 --LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKA 461

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
             +  +  ++T    A    H ++V  L       P          +  A + G+ + V 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVL 520

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
            + +++ S   +    G TPL +AA  G++ + +LL+ER A  +     +G T L  A +
Sbjct: 521 ALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVH 578

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           H N +IVK LL +G      A NGYT   +    N
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613



 Score =  105 bits (262), Expect = 2e-22
 Identities = 91/335 (27%), Positives = 155/335 (46%), Gaps = 24/335 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++ + + GNTAL  AA  G + +VR L+  GA+VN+++  G++ L  AA+  H+ V   L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L++GA+ N     G + L VA + GH  VV  L+  G                      +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT------------------KGKV 172

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
            + AL  A ++       +L++   +P+  ++T G++PL +AA    L VAQ L+ +GA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
            +       T   +A    +  +V   LD    +  KT +E       H         + 
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP---LHCAARNGHVRIS 288

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
           EI  +  + +     +G +P+ +AA    L  V+LL++  A++D     H  T L  A +
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAH 347

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
            G+  + K LL++GA    RA NG+T   +    N
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 105/411 (25%), Positives = 164/411 (39%), Gaps = 54/411 (13%)

Query: 52  AEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
           A +AG        V     V+   + G T L  AA   H  +V+FLL  GA+ N     G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 112 WSALMQAARFGHVSVAHLLLDHG---------------------ADVNAQN--------R 142
           ++ L  A + GH +V   L+++G                     A V  QN        +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 143 LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDEPL----------- 190
            G + L +A+   +L V +LLL  GA V+    +G   L +   R   +           
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 191 -------DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQ 243
                  ++T L  A ++GH  +  +L++ GA P  A    G SP+ +AA    L   + 
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 244 LVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMG 303
           L++  A  D +++   T   VA  C H  +   L  L                 H     
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL--LDKGAKPNSRALNGFTPLHIACKK 381

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
           N   V E+  +  + ++ V   G TPL +A+  G L +V+ L++R A      +V   T 
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETP 440

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
           L  A   G+ E+ KYLL   A V  +AK+  T       +    T +V+LL
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG--HTNMVKLL 489



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 87/291 (29%), Positives = 127/291 (43%), Gaps = 28/291 (9%)

Query: 77  AGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGAD 136
           AG+T L  AA  GH   V  LL + AS       G++ L  AA++G V VA LLL+  A 
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE------------------ 178
            NA  + G + L VA    +L +VKLLL  G     H P+                    
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--SPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 179 ---QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALT 235
              Q G   + +    +T L  A Q GH  +V LL+   A+ N   ++ G +PL L A  
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS-GLTPLHLVAQE 678

Query: 236 GRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRP 294
           G + VA  L++ G   D  + +  T   VA    +  LV + L     V  KT  +    
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT--KLGYS 736

Query: 295 DIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLL 345
            +  A + G+  +V  +     S  N V+ DG TPL +A   G +++  +L
Sbjct: 737 PLHQAAQQGHTDIVTLLLKNGAS-PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 86/292 (29%), Positives = 124/292 (42%), Gaps = 37/292 (12%)

Query: 2   GEGGLPPAFQLLLRACDQGDTETARRLLEPGAA--EPAERGAEP-EAGAEPAGAEVAGPG 58
           G+ GL P    L  A    + +  + LL  G +   PA  G  P    A+    EVA   
Sbjct: 566 GKNGLTP----LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 59  AAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQA 118
               G+  A          G T L  AA  GH  +V  LL + A+ N  N  G + L   
Sbjct: 622 LQYGGSANA------ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 119 ARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE 178
           A+ GHV VA +L+ HG  V+A  R+G + L VAS  G++ +VK LL+  A V        
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-------- 727

Query: 179 QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRL 238
                 +    L  + L  A Q GH  +V LL++ GA PN  + + G +PL +A   G +
Sbjct: 728 ------NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS-SDGTTPLAIAKRLGYI 780

Query: 239 GVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
            V   L           V ++T+F +  D       + +D +  V     EE
Sbjct: 781 SVTDVL---------KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEE 823


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  129 bits (325), Expect = 9e-30
 Identities = 106/364 (29%), Positives = 178/364 (48%), Gaps = 27/364 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+ + + G T L  A+  G+  +VR LL RGA + ++     + L  AAR GHV ++ +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-----------------HH 173
           LDHGA + A+ + G S + +A++G HL  V+LLL+  A +D                 HH
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 174 HPSGEQLGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLML 231
             +   L  G   +       T L  A +  H  V+ LL++ GA  + A    G +PL +
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID-AVTESGLTPLHV 410

Query: 232 AALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEE 290
           A+  G L + + L+++GA+P+  +V  +T   +A    H ++  Y L     V  K  ++
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHA 350
             +  +  A ++G+  +VK +  E+ ++ NL    G TPL +AA  G +  V  L+E+ A
Sbjct: 471 --QTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 351 DVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
                 +  G+T L  A  +G   + + LL + A      KNG T   + +  N+ D  +
Sbjct: 528 S-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD--I 584

Query: 411 VRLL 414
           V+LL
Sbjct: 585 VKLL 588



 Score =  121 bits (303), Expect = 3e-27
 Identities = 115/380 (30%), Positives = 169/380 (44%), Gaps = 59/380 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D   E+G T L  A+  GH P+V+ LL+RGAS N  N    + L  AAR GH  VA  L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L + A VNA+ +   + L  A+R GH  +VKLLLE  A  +    +G             
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH------------ 504

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTV-GWSPLMLAALTGRLGVAQQLVEKGA 249
             T L  A + GH   V  L+E   + + A  T  G++PL +AA  G++ VA+ L+E+ A
Sbjct: 505 --TPLHIAAREGHVETVLALLE--KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYL---------------DPLTTVRPKTDEEKRRP 294
           +P+       T   VA+   + D+V  L                PL     +   E  R 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 295 DIFHALKMGNFQLVKEIADEDPSHV--------------------NLVNGDGATPLMLAA 334
                L+ G     + +    P H+                    NL N  G TPL L A
Sbjct: 621 ----LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676

Query: 335 VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY 394
             G + +  +L++    VD    + G+T L  A+++GN ++VK+LL   ADV  + K GY
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 395 TAFDLVMLLNDPDTELVRLL 414
           +   L        T++V LL
Sbjct: 736 S--PLHQAAQQGHTDIVTLL 753



 Score =  115 bits (287), Expect = 2e-25
 Identities = 98/335 (29%), Positives = 155/335 (46%), Gaps = 18/335 (5%)

Query: 70  PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
           P+    + G + +  AA G H   VR LL+  A ++       + L  AA  GH  VA +
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
           LLD GA  N++   G + L +A +  H+ V++LLL+ GA +D    SG            
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG------------ 404

Query: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
             +T L  A   GH  +V+ L++ GA PN +   V  +PL +AA  G   VA+ L++  A
Sbjct: 405 --LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKA 461

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
             +  +  ++T    A    H ++V  L       P          +  A + G+ + V 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVL 520

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
            + +++ S   +    G TPL +AA  G++ + +LL+ER A  +     +G T L  A +
Sbjct: 521 ALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVH 578

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           H N +IVK LL +G      A NGYT   +    N
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613



 Score =  105 bits (262), Expect = 2e-22
 Identities = 91/335 (27%), Positives = 155/335 (46%), Gaps = 24/335 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++ + + GNTAL  AA  G + +VR L+  GA+VN+++  G++ L  AA+  H+ V   L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L++GA+ N     G + L VA + GH  VV  L+  G                      +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT------------------KGKV 172

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
            + AL  A ++       +L++   +P+  ++T G++PL +AA    L VAQ L+ +GA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
            +       T   +A    +  +V   LD    +  KT +E       H         + 
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP---LHCAARNGHVRIS 288

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
           EI  +  + +     +G +P+ +AA    L  V+LL++  A++D     H  T L  A +
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAH 347

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
            G+  + K LL++GA    RA NG+T   +    N
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 105/411 (25%), Positives = 164/411 (39%), Gaps = 54/411 (13%)

Query: 52  AEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
           A +AG        V     V+   + G T L  AA   H  +V+FLL  GA+ N     G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 112 WSALMQAARFGHVSVAHLLLDHG---------------------ADVNAQN--------R 142
           ++ L  A + GH +V   L+++G                     A V  QN        +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 143 LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDEPL----------- 190
            G + L +A+   +L V +LLL  GA V+    +G   L +   R   +           
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 191 -------DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQ 243
                  ++T L  A ++GH  +  +L++ GA P  A    G SP+ +AA    L   + 
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 244 LVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMG 303
           L++  A  D +++   T   VA  C H  +   L  L                 H     
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL--LDKGAKPNSRALNGFTPLHIACKK 381

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
           N   V E+  +  + ++ V   G TPL +A+  G L +V+ L++R A      +V   T 
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETP 440

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
           L  A   G+ E+ KYLL   A V  +AK+  T       +    T +V+LL
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG--HTNMVKLL 489



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 87/291 (29%), Positives = 127/291 (43%), Gaps = 28/291 (9%)

Query: 77  AGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGAD 136
           AG+T L  AA  GH   V  LL + AS       G++ L  AA++G V VA LLL+  A 
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE------------------ 178
            NA  + G + L VA    +L +VKLLL  G     H P+                    
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--SPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 179 ---QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALT 235
              Q G   + +    +T L  A Q GH  +V LL+   A+ N   ++ G +PL L A  
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS-GLTPLHLVAQE 678

Query: 236 GRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRP 294
           G + VA  L++ G   D  + +  T   VA    +  LV + L     V  KT  +    
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT--KLGYS 736

Query: 295 DIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLL 345
            +  A + G+  +V  +     S  N V+ DG TPL +A   G +++  +L
Sbjct: 737 PLHQAAQQGHTDIVTLLLKNGAS-PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 86/292 (29%), Positives = 124/292 (42%), Gaps = 37/292 (12%)

Query: 2   GEGGLPPAFQLLLRACDQGDTETARRLLEPGAA--EPAERGAEP-EAGAEPAGAEVAGPG 58
           G+ GL P    L  A    + +  + LL  G +   PA  G  P    A+    EVA   
Sbjct: 566 GKNGLTP----LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 59  AAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQA 118
               G+  A          G T L  AA  GH  +V  LL + A+ N  N  G + L   
Sbjct: 622 LQYGGSANA------ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 119 ARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE 178
           A+ GHV VA +L+ HG  V+A  R+G + L VAS  G++ +VK LL+  A V        
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-------- 727

Query: 179 QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRL 238
                 +    L  + L  A Q GH  +V LL++ GA PN  + + G +PL +A   G +
Sbjct: 728 ------NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS-SDGTTPLAIAKRLGYI 780

Query: 239 GVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
            V   L           V ++T+F +  D       + +D +  V     EE
Sbjct: 781 SVTDVL---------KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEE 823


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  129 bits (325), Expect = 9e-30
 Identities = 106/364 (29%), Positives = 178/364 (48%), Gaps = 27/364 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+ + + G T L  A+  G+  +VR LL RGA + ++     + L  AAR GHV ++ +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-----------------HH 173
           LDHGA + A+ + G S + +A++G HL  V+LLL+  A +D                 HH
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 174 HPSGEQLGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLML 231
             +   L  G   +       T L  A +  H  V+ LL++ GA  + A    G +PL +
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID-AVTESGLTPLHV 410

Query: 232 AALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEE 290
           A+  G L + + L+++GA+P+  +V  +T   +A    H ++  Y L     V  K  ++
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHA 350
             +  +  A ++G+  +VK +  E+ ++ NL    G TPL +AA  G +  V  L+E+ A
Sbjct: 471 --QTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 351 DVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
                 +  G+T L  A  +G   + + LL + A      KNG T   + +  N+ D  +
Sbjct: 528 S-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD--I 584

Query: 411 VRLL 414
           V+LL
Sbjct: 585 VKLL 588



 Score =  121 bits (303), Expect = 3e-27
 Identities = 115/380 (30%), Positives = 169/380 (44%), Gaps = 59/380 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D   E+G T L  A+  GH P+V+ LL+RGAS N  N    + L  AAR GH  VA  L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L + A VNA+ +   + L  A+R GH  +VKLLLE  A  +    +G             
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH------------ 504

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTV-GWSPLMLAALTGRLGVAQQLVEKGA 249
             T L  A + GH   V  L+E   + + A  T  G++PL +AA  G++ VA+ L+E+ A
Sbjct: 505 --TPLHIAAREGHVETVLALLE--KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYL---------------DPLTTVRPKTDEEKRRP 294
           +P+       T   VA+   + D+V  L                PL     +   E  R 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 295 DIFHALKMGNFQLVKEIADEDPSHV--------------------NLVNGDGATPLMLAA 334
                L+ G     + +    P H+                    NL N  G TPL L A
Sbjct: 621 ----LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676

Query: 335 VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY 394
             G + +  +L++    VD    + G+T L  A+++GN ++VK+LL   ADV  + K GY
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 395 TAFDLVMLLNDPDTELVRLL 414
           +   L        T++V LL
Sbjct: 736 S--PLHQAAQQGHTDIVTLL 753



 Score =  115 bits (287), Expect = 2e-25
 Identities = 98/335 (29%), Positives = 155/335 (46%), Gaps = 18/335 (5%)

Query: 70  PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
           P+    + G + +  AA G H   VR LL+  A ++       + L  AA  GH  VA +
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
           LLD GA  N++   G + L +A +  H+ V++LLL+ GA +D    SG            
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG------------ 404

Query: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
             +T L  A   GH  +V+ L++ GA PN +   V  +PL +AA  G   VA+ L++  A
Sbjct: 405 --LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKA 461

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
             +  +  ++T    A    H ++V  L       P          +  A + G+ + V 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVL 520

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
            + +++ S   +    G TPL +AA  G++ + +LL+ER A  +     +G T L  A +
Sbjct: 521 ALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVH 578

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           H N +IVK LL +G      A NGYT   +    N
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613



 Score =  105 bits (262), Expect = 2e-22
 Identities = 91/335 (27%), Positives = 155/335 (46%), Gaps = 24/335 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++ + + GNTAL  AA  G + +VR L+  GA+VN+++  G++ L  AA+  H+ V   L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L++GA+ N     G + L VA + GH  VV  L+  G                      +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT------------------KGKV 172

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
            + AL  A ++       +L++   +P+  ++T G++PL +AA    L VAQ L+ +GA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
            +       T   +A    +  +V   LD    +  KT +E       H         + 
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP---LHCAARNGHVRIS 288

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
           EI  +  + +     +G +P+ +AA    L  V+LL++  A++D     H  T L  A +
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAH 347

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
            G+  + K LL++GA    RA NG+T   +    N
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 105/411 (25%), Positives = 164/411 (39%), Gaps = 54/411 (13%)

Query: 52  AEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
           A +AG        V     V+   + G T L  AA   H  +V+FLL  GA+ N     G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 112 WSALMQAARFGHVSVAHLLLDHG---------------------ADVNAQN--------R 142
           ++ L  A + GH +V   L+++G                     A V  QN        +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 143 LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDEPL----------- 190
            G + L +A+   +L V +LLL  GA V+    +G   L +   R   +           
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 191 -------DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQ 243
                  ++T L  A ++GH  +  +L++ GA P  A    G SP+ +AA    L   + 
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 244 LVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMG 303
           L++  A  D +++   T   VA  C H  +   L  L                 H     
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL--LDKGAKPNSRALNGFTPLHIACKK 381

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
           N   V E+  +  + ++ V   G TPL +A+  G L +V+ L++R A      +V   T 
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETP 440

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
           L  A   G+ E+ KYLL   A V  +AK+  T       +    T +V+LL
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG--HTNMVKLL 489



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 87/291 (29%), Positives = 127/291 (43%), Gaps = 28/291 (9%)

Query: 77  AGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGAD 136
           AG+T L  AA  GH   V  LL + AS       G++ L  AA++G V VA LLL+  A 
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE------------------ 178
            NA  + G + L VA    +L +VKLLL  G     H P+                    
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--SPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 179 ---QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALT 235
              Q G   + +    +T L  A Q GH  +V LL+   A+ N   ++ G +PL L A  
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS-GLTPLHLVAQE 678

Query: 236 GRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRP 294
           G + VA  L++ G   D  + +  T   VA    +  LV + L     V  KT  +    
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT--KLGYS 736

Query: 295 DIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLL 345
            +  A + G+  +V  +     S  N V+ DG TPL +A   G +++  +L
Sbjct: 737 PLHQAAQQGHTDIVTLLLKNGAS-PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 86/292 (29%), Positives = 124/292 (42%), Gaps = 37/292 (12%)

Query: 2   GEGGLPPAFQLLLRACDQGDTETARRLLEPGAA--EPAERGAEP-EAGAEPAGAEVAGPG 58
           G+ GL P    L  A    + +  + LL  G +   PA  G  P    A+    EVA   
Sbjct: 566 GKNGLTP----LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 59  AAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQA 118
               G+  A          G T L  AA  GH  +V  LL + A+ N  N  G + L   
Sbjct: 622 LQYGGSANA------ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 119 ARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE 178
           A+ GHV VA +L+ HG  V+A  R+G + L VAS  G++ +VK LL+  A V        
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-------- 727

Query: 179 QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRL 238
                 +    L  + L  A Q GH  +V LL++ GA PN  + + G +PL +A   G +
Sbjct: 728 ------NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS-SDGTTPLAIAKRLGYI 780

Query: 239 GVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
            V   L           V ++T+F +  D       + +D +  V     EE
Sbjct: 781 SVTDVL---------KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEE 823


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  129 bits (325), Expect = 9e-30
 Identities = 106/364 (29%), Positives = 178/364 (48%), Gaps = 27/364 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+ + + G T L  A+  G+  +VR LL RGA + ++     + L  AAR GHV ++ +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD-----------------HH 173
           LDHGA + A+ + G S + +A++G HL  V+LLL+  A +D                 HH
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351

Query: 174 HPSGEQLGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLML 231
             +   L  G   +       T L  A +  H  V+ LL++ GA  + A    G +PL +
Sbjct: 352 RVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID-AVTESGLTPLHV 410

Query: 232 AALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEE 290
           A+  G L + + L+++GA+P+  +V  +T   +A    H ++  Y L     V  K  ++
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDD 470

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHA 350
             +  +  A ++G+  +VK +  E+ ++ NL    G TPL +AA  G +  V  L+E+ A
Sbjct: 471 --QTPLHCAARIGHTNMVKLLL-ENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEA 527

Query: 351 DVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
                 +  G+T L  A  +G   + + LL + A      KNG T   + +  N+ D  +
Sbjct: 528 S-QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLD--I 584

Query: 411 VRLL 414
           V+LL
Sbjct: 585 VKLL 588



 Score =  121 bits (303), Expect = 3e-27
 Identities = 115/380 (30%), Positives = 169/380 (44%), Gaps = 59/380 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D   E+G T L  A+  GH P+V+ LL+RGAS N  N    + L  AAR GH  VA  L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L + A VNA+ +   + L  A+R GH  +VKLLLE  A  +    +G             
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH------------ 504

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTV-GWSPLMLAALTGRLGVAQQLVEKGA 249
             T L  A + GH   V  L+E   + + A  T  G++PL +AA  G++ VA+ L+E+ A
Sbjct: 505 --TPLHIAAREGHVETVLALLE--KEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDA 560

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYL---------------DPLTTVRPKTDEEKRRP 294
           +P+       T   VA+   + D+V  L                PL     +   E  R 
Sbjct: 561 HPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARS 620

Query: 295 DIFHALKMGNFQLVKEIADEDPSHV--------------------NLVNGDGATPLMLAA 334
                L+ G     + +    P H+                    NL N  G TPL L A
Sbjct: 621 ----LLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676

Query: 335 VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY 394
             G + +  +L++    VD    + G+T L  A+++GN ++VK+LL   ADV  + K GY
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM-GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 395 TAFDLVMLLNDPDTELVRLL 414
           +   L        T++V LL
Sbjct: 736 S--PLHQAAQQGHTDIVTLL 753



 Score =  115 bits (287), Expect = 2e-25
 Identities = 98/335 (29%), Positives = 155/335 (46%), Gaps = 18/335 (5%)

Query: 70  PVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHL 129
           P+    + G + +  AA G H   VR LL+  A ++       + L  AA  GH  VA +
Sbjct: 297 PIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKV 356

Query: 130 LLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
           LLD GA  N++   G + L +A +  H+ V++LLL+ GA +D    SG            
Sbjct: 357 LLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESG------------ 404

Query: 190 LDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
             +T L  A   GH  +V+ L++ GA PN +   V  +PL +AA  G   VA+ L++  A
Sbjct: 405 --LTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVE-TPLHMAARAGHTEVAKYLLQNKA 461

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
             +  +  ++T    A    H ++V  L       P          +  A + G+ + V 
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLE-NNANPNLATTAGHTPLHIAAREGHVETVL 520

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
            + +++ S   +    G TPL +AA  G++ + +LL+ER A  +     +G T L  A +
Sbjct: 521 ALLEKEASQACMTK-KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGK-NGLTPLHVAVH 578

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           H N +IVK LL +G      A NGYT   +    N
Sbjct: 579 HNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613



 Score =  105 bits (262), Expect = 2e-22
 Identities = 91/335 (27%), Positives = 155/335 (46%), Gaps = 24/335 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++ + + GNTAL  AA  G + +VR L+  GA+VN+++  G++ L  AA+  H+ V   L
Sbjct: 71  LETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFL 130

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L++GA+ N     G + L VA + GH  VV  L+  G                      +
Sbjct: 131 LENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT------------------KGKV 172

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
            + AL  A ++       +L++   +P+  ++T G++PL +AA    L VAQ L+ +GA+
Sbjct: 173 RLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGAS 231

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
            +       T   +A    +  +V   LD    +  KT +E       H         + 
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP---LHCAARNGHVRIS 288

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
           EI  +  + +     +G +P+ +AA    L  V+LL++  A++D     H  T L  A +
Sbjct: 289 EILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAH 347

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
            G+  + K LL++GA    RA NG+T   +    N
Sbjct: 348 CGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKN 382



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 105/411 (25%), Positives = 164/411 (39%), Gaps = 54/411 (13%)

Query: 52  AEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
           A +AG        V     V+   + G T L  AA   H  +V+FLL  GA+ N     G
Sbjct: 85  AALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 112 WSALMQAARFGHVSVAHLLLDHG---------------------ADVNAQN--------R 142
           ++ L  A + GH +V   L+++G                     A V  QN        +
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 143 LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDEPL----------- 190
            G + L +A+   +L V +LLL  GA V+    +G   L +   R   +           
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 191 -------DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQ 243
                  ++T L  A ++GH  +  +L++ GA P  A    G SP+ +AA    L   + 
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGA-PIQAKTKNGLSPIHMAAQGDHLDCVRL 323

Query: 244 LVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMG 303
           L++  A  D +++   T   VA  C H  +   L  L                 H     
Sbjct: 324 LLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL--LDKGAKPNSRALNGFTPLHIACKK 381

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
           N   V E+  +  + ++ V   G TPL +A+  G L +V+ L++R A      +V   T 
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETP 440

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
           L  A   G+ E+ KYLL   A V  +AK+  T       +    T +V+LL
Sbjct: 441 LHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG--HTNMVKLL 489



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 87/291 (29%), Positives = 127/291 (43%), Gaps = 28/291 (9%)

Query: 77  AGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGAD 136
           AG+T L  AA  GH   V  LL + AS       G++ L  AA++G V VA LLL+  A 
Sbjct: 502 AGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAH 561

Query: 137 VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE------------------ 178
            NA  + G + L VA    +L +VKLLL  G     H P+                    
Sbjct: 562 PNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGG--SPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 179 ---QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALT 235
              Q G   + +    +T L  A Q GH  +V LL+   A+ N   ++ G +PL L A  
Sbjct: 620 SLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS-GLTPLHLVAQE 678

Query: 236 GRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRP 294
           G + VA  L++ G   D  + +  T   VA    +  LV + L     V  KT  +    
Sbjct: 679 GHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKT--KLGYS 736

Query: 295 DIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLL 345
            +  A + G+  +V  +     S  N V+ DG TPL +A   G +++  +L
Sbjct: 737 PLHQAAQQGHTDIVTLLLKNGAS-PNEVSSDGTTPLAIAKRLGYISVTDVL 786



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 86/292 (29%), Positives = 124/292 (42%), Gaps = 37/292 (12%)

Query: 2   GEGGLPPAFQLLLRACDQGDTETARRLLEPGAA--EPAERGAEP-EAGAEPAGAEVAGPG 58
           G+ GL P    L  A    + +  + LL  G +   PA  G  P    A+    EVA   
Sbjct: 566 GKNGLTP----LHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSL 621

Query: 59  AAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQA 118
               G+  A          G T L  AA  GH  +V  LL + A+ N  N  G + L   
Sbjct: 622 LQYGGSANA------ESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 119 ARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE 178
           A+ GHV VA +L+ HG  V+A  R+G + L VAS  G++ +VK LL+  A V        
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADV-------- 727

Query: 179 QLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRL 238
                 +    L  + L  A Q GH  +V LL++ GA PN  + + G +PL +A   G +
Sbjct: 728 ------NAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVS-SDGTTPLAIAKRLGYI 780

Query: 239 GVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
            V   L           V ++T+F +  D       + +D +  V     EE
Sbjct: 781 SVTDVL---------KVVTDETSFVLVSDKHRMSFPETVDEILDVSEDEGEE 823


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  129 bits (323), Expect = 2e-29
 Identities = 104/330 (31%), Positives = 158/330 (47%), Gaps = 53/330 (16%)

Query: 66  GAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVS 125
           GA V     D+   T L  +A  G   +V+ LL++GAS N+    G++ L  +AR GH  
Sbjct: 489 GAQVEAKAKDD--QTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHED 546

Query: 126 VAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGS 185
           VA  LLDHGA ++   + G + L VA++ G L V  LLL+  A  D    SG        
Sbjct: 547 VAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSG-------- 598

Query: 186 RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLV 245
                 +T L  A  + ++ V  LL++ GA P HAA   G++PL +AA   ++ +A  L+
Sbjct: 599 ------LTPLHVAAHYDNQKVALLLLDQGASP-HAAAKNGYTPLHIAAKKNQMDIATTLL 651

Query: 246 EKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNF 305
           E GA+ + ++     +  +A    H D+V                        +L +G  
Sbjct: 652 EYGADANAVTRQGIASVHLAAQEGHVDMV------------------------SLLLGR- 686

Query: 306 QLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALM 365
                      ++VNL N  G TPL LAA   ++ + ++LV + A VD Q  + G+T L 
Sbjct: 687 ----------NANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKM-GYTPLH 735

Query: 366 QATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
              ++GN +IV +LL   A V  + KNGYT
Sbjct: 736 VGCHYGNIKIVNFLLQHSAKVNAKTKNGYT 765



 Score =  110 bits (275), Expect = 6e-24
 Identities = 94/339 (27%), Positives = 150/339 (44%), Gaps = 51/339 (15%)

Query: 69  VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAH 128
           VPVD       TAL  AA  GH  + + LL + A+ N++   G++ L  A +   + V  
Sbjct: 358 VPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVME 417

Query: 129 LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE 188
           LLL HGA + A    G + + VA+  GH+ +V  L+  GA  +  +  GE          
Sbjct: 418 LLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE---------- 467

Query: 189 PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKG 248
               TAL  A + G   VVR L++ GA     A+    +PL ++A  G+  + QQL+++G
Sbjct: 468 ----TALHMAARSGQAEVVRYLVQDGAQVEAKAKD-DQTPLHISARLGKADIVQQLLQQG 522

Query: 249 ANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLV 308
           A+P+  +    T   ++    H D+  +L                  + H          
Sbjct: 523 ASPNAATTSGYTPLHLSAREGHEDVAAFL------------------LDHG--------- 555

Query: 309 KEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQAT 368
                   + +++    G TPL +AA  G+L +  LL+++ A  D      G T L  A 
Sbjct: 556 --------ASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGK-SGLTPLHVAA 606

Query: 369 YHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPD 407
           ++ N+++   LL+QGA     AKNGYT   +    N  D
Sbjct: 607 HYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645



 Score =  104 bits (259), Expect = 4e-22
 Identities = 108/396 (27%), Positives = 178/396 (44%), Gaps = 47/396 (11%)

Query: 38  ERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFL 97
           +R  + +A A    A  AG    A   +   V ++  ++ G  AL  A+  GH  +V  L
Sbjct: 34  DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93

Query: 98  LRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHL 157
           L+R A+V++    G +AL  A+  G   V  +L+ +GA+VNAQ++ G + L +A++  HL
Sbjct: 94  LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHL 153

Query: 158 GVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGA-- 215
            VVK LL+ GA        G               T L  A+Q GH+ VV LL+E     
Sbjct: 154 EVVKFLLDNGASQSLATEDG--------------FTPLAVALQQGHDQVVSLLLENDTKG 199

Query: 216 -------------DPNHAARTV-------------GWSPLMLAALTGRLGVAQQLVEKGA 249
                        D   AA  +             G++PL +AA  G + VA  L+ + A
Sbjct: 200 KVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAA 259

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLV 308
             D  +  + T   VA    + ++V   LD    +  KT +      +    + G+ Q+V
Sbjct: 260 AVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD--GLTPLHCGARSGHEQVV 317

Query: 309 KEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQAT 368
           + + D     ++    +G +PL +A     L  VQLL++ +  VD   + +  TAL  A 
Sbjct: 318 EMLLDRAAPILSKTK-NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY-LTALHVAA 375

Query: 369 YHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           + G+ ++ K LL++ A+   +A NG+T   +    N
Sbjct: 376 HCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKN 411



 Score =  101 bits (251), Expect = 3e-21
 Identities = 98/357 (27%), Positives = 152/357 (42%), Gaps = 53/357 (14%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           VD +     T L  A+  G+  +V+ LL RGA ++++   G + L   AR GH  V  +L
Sbjct: 261 VDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEML 320

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           LD  A + ++ + G S L +A++G HL  V+LLL+    VD               D   
Sbjct: 321 LDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVD---------------DVTN 365

Query: 191 D-ITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA 249
           D +TAL  A   GH  V ++L++  A+PN  A   G++PL +A    R+ V + L++ GA
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALN-GFTPLHIACKKNRIKVMELLLKHGA 424

Query: 250 NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVK 309
           +   ++    T   VA                                    MG+  +V 
Sbjct: 425 SIQAVTESGLTPIHVAAF----------------------------------MGHVNIVS 450

Query: 310 EIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATY 369
           ++     S  N  N  G T L +AA +GQ  +V+ LV+  A V+ + +    T L  +  
Sbjct: 451 QLMHHGASP-NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK-AKDDQTPLHISAR 508

Query: 370 HGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKG 426
            G  +IV+ LL QGA       +GYT   L       D     L     + +   KG
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKG 565



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 70/271 (25%), Positives = 121/271 (44%), Gaps = 26/271 (9%)

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLL 131
           D + ++G T L  AA   ++ +   LL +GAS ++    G++ L  AA+   + +A  LL
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651

Query: 132 DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDE-- 188
           ++GAD NA  R G + + +A++ GH+ +V LLL   A V+  + SG   L L    D   
Sbjct: 652 EYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711

Query: 189 ----------------PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLA 232
                            +  T L     +G+  +V  L++  A  N   +  G++PL  A
Sbjct: 712 VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN-GYTPLHQA 770

Query: 233 ALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKR 292
           A  G   +   L++  A+P+ L+V   TA  +A        + Y+  + T++  T+E   
Sbjct: 771 AQQGHTHIINVLLQNNASPNELTVNGNTALGIA------RRLGYISVVDTLKIVTEETMT 824

Query: 293 RPDIFHALKMGNFQLVKEIADEDPSHVNLVN 323
              +    KM   + + E+ D     V   N
Sbjct: 825 TTTVTEKHKMNVPETMNEVLDMSDDEVRKAN 855



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 41/146 (28%), Positives = 74/146 (50%), Gaps = 14/146 (9%)

Query: 65  VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV 124
           +G    V+ S+++G T L  AA      +   L+ +GA V+++   G++ L     +G++
Sbjct: 684 LGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNI 743

Query: 125 SVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGG 184
            + + LL H A VNA+ + G + L  A++ GH  ++ +LL+  A       S  +L + G
Sbjct: 744 KIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNA-------SPNELTVNG 796

Query: 185 SRDEPLDITALMAAIQHGHEAVVRLL 210
           +       TAL  A + G+ +VV  L
Sbjct: 797 N-------TALGIARRLGYISVVDTL 815



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 3/98 (3%)

Query: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
           D     + AA  G L      ++   D++  +  +G  AL  A+  G+ E+V  LL + A
Sbjct: 40  DANASYLRAARAGHLEKALDYIKNGVDINICNQ-NGLNALHLASKEGHVEVVSELLQREA 98

Query: 385 DVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVN 422
           +V    K G TA  +  L      E+V++L +    VN
Sbjct: 99  NVDAATKKGNTALHIASLAG--QAEVVKVLVTNGANVN 134


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  119 bits (298), Expect = 1e-26
 Identities = 103/333 (30%), Positives = 147/333 (44%), Gaps = 51/333 (15%)

Query: 69  VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAH 128
           V VDC   +G T L  AA      L   LL  GA  N  +  GW+ L  AA+ G    A 
Sbjct: 386 VDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTAR 445

Query: 129 LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE 188
           LLLDHGA V+AQ R G + L +A++     V +LL+   A  + H   G+          
Sbjct: 446 LLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGK---------- 495

Query: 189 PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKG 248
               T L  A   GH ++V+LL   GA+ +   R +  +PL LA   G++   Q L++ G
Sbjct: 496 ----TPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR-TPLHLAVERGKVRAIQHLLKSG 550

Query: 249 ANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLV 308
           A PD    L+++ +                PL T                A   G + + 
Sbjct: 551 AVPD---ALDQSGY---------------GPLHT----------------AAARGKYLIC 576

Query: 309 KEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQAT 368
           K +     S + L    G TPL LAA  G L ++ LL E HA++    +V+ WT L  A 
Sbjct: 577 KMLLRYGAS-LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVN-WTPLHLAA 634

Query: 369 YHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM 401
            HG + +V  LL  GAD     ++G+T   L +
Sbjct: 635 RHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667



 Score =  101 bits (252), Expect = 3e-21
 Identities = 95/312 (30%), Positives = 139/312 (44%), Gaps = 24/312 (7%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           VD  +  G T L  AA    E + R L+ R A  N     G + L  AA FGHVS+  LL
Sbjct: 454 VDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLL 513

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
              GA+++AQ R   + L +A   G +  ++ LL++GA  D    + +Q G G       
Sbjct: 514 TSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPD----ALDQSGYG------- 562

Query: 191 DITALMAAIQHGHEAVVRLLMEWGAD---PNHAARTVGWSPLMLAALTGRLGVAQQLVEK 247
               L  A   G   + ++L+ +GA    P H     GW+PL LAA  G L +   L E 
Sbjct: 563 ---PLHTAAARGKYLICKMLLRYGASLELPTHQ----GWTPLHLAAYKGHLEIIHLLAES 615

Query: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQL 307
            AN   L  +  T   +A       +V  L       P   E+     +  A++   F  
Sbjct: 616 HANMGALGAVNWTPLHLAARHGEEAVVSAL-LQCGADPNAAEQSGWTPLHLAVQRSTFLS 674

Query: 308 VKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQA 367
           V  +  E  ++V+  N  G TP  LAA+ G  A++++LVE  A +D QD V   T L  A
Sbjct: 675 VINLL-EHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGV-SCTPLQLA 732

Query: 368 TYHGNKEIVKYL 379
                + I+ +L
Sbjct: 733 LRSRKQGIMSFL 744



 Score =  100 bits (248), Expect = 8e-21
 Identities = 96/329 (29%), Positives = 143/329 (43%), Gaps = 22/329 (6%)

Query: 75  DEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHG 134
           DE G   L FAA  G +   R LL  GA V+++   GW+ L  AA+    +VA LL+   
Sbjct: 425 DEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQ 484

Query: 135 ADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITA 194
           AD N     G + L VA+  GH+ +VKLL   GA +D      +Q  L          T 
Sbjct: 485 ADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELD-----AQQRNLR---------TP 530

Query: 195 LMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHL 254
           L  A++ G    ++ L++ GA P+ A    G+ PL  AA  G+  + + L+  GA+ +  
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPD-ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELP 589

Query: 255 SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD- 313
           +    T   +A    H +++  L                P +  A + G   +V  +   
Sbjct: 590 THQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP-LHLAARHGEEAVVSALLQC 648

Query: 314 -EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGN 372
             DP   N     G TPL LA        V  L+E HA+V  ++ V GWT    A   GN
Sbjct: 649 GADP---NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKV-GWTPAHLAALKGN 704

Query: 373 KEIVKYLLNQGADVTLRAKNGYTAFDLVM 401
             I+K L+  GA + ++     T   L +
Sbjct: 705 TAILKVLVEAGAQLDVQDGVSCTPLQLAL 733



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 68/207 (32%), Positives = 100/207 (48%), Gaps = 15/207 (7%)

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLL 131
           D  D++G   L  AAA G   + + LLR GAS+    H GW+ L  AA  GH+ + HLL 
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613

Query: 132 DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLD 191
           +  A++ A   +  + L +A+R G   VV  LL+ GA  +    SG              
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSG-------------- 659

Query: 192 ITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
            T L  A+Q      V  L+E  A+  HA   VGW+P  LAAL G   + + LVE GA  
Sbjct: 660 WTPLHLAVQRSTFLSVINLLEHHANV-HARNKVGWTPAHLAALKGNTAILKVLVEAGAQL 718

Query: 252 DHLSVLEKTAFEVALDCKHRDLVDYLD 278
           D    +  T  ++AL  + + ++ +L+
Sbjct: 719 DVQDGVSCTPLQLALRSRKQGIMSFLE 745



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 31/126 (24%), Positives = 59/126 (46%), Gaps = 7/126 (5%)

Query: 56  GPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSAL 115
           G  A  +  +      + ++++G T L  A        V  LL   A+V++RN  GW+  
Sbjct: 637 GEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPA 696

Query: 116 MQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHP 175
             AA  G+ ++  +L++ GA ++ Q+ +  + L +A R    G++       +F++   P
Sbjct: 697 HLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIM-------SFLEGKEP 749

Query: 176 SGEQLG 181
           S   LG
Sbjct: 750 SVATLG 755



 Score = 37.7 bits (86), Expect = 0.047
 Identities = 26/99 (26%), Positives = 41/99 (41%), Gaps = 1/99 (1%)

Query: 328 TPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVT 387
           TPL      G +  V+LL+    DVD Q +  G+T L+ A      ++   LL  GAD  
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQ-TASGYTPLLIAAQDQQPDLCALLLAHGADAN 422

Query: 388 LRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKG 426
              ++G+          D  T  + L    C+   + +G
Sbjct: 423 RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREG 461


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  117 bits (292), Expect = 6e-26
 Identities = 98/324 (30%), Positives = 156/324 (48%), Gaps = 18/324 (5%)

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLL 131
           D ++  G TAL  AA  G   +VR LLR GA V++R     + L  A+R G   +  LLL
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496

Query: 132 DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLD 191
            H A  +A    G + L +++R G + V  +LLEAGA     H    + G          
Sbjct: 497 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA----AHSLATKKG---------- 542

Query: 192 ITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
            T L  A ++G   V +LL++  A  + A +  G +PL +AA      VA  L+EKGA+P
Sbjct: 543 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASP 601

Query: 252 DHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEI 311
              +    T   +A       +   L           ++   P +  A + G+  +V  +
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP-LHLASQEGHTDMVTLL 660

Query: 312 ADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHG 371
            D+  +++++    G T L LAA   ++ +  +L +  AD D    + G+T L+ A ++G
Sbjct: 661 LDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYG 718

Query: 372 NKEIVKYLLNQGADVTLRAKNGYT 395
           N ++V +LL QGA+V  + KNGYT
Sbjct: 719 NVKMVNFLLKQGANVNAKTKNGYT 742



 Score =  105 bits (263), Expect = 1e-22
 Identities = 108/391 (27%), Positives = 171/391 (43%), Gaps = 25/391 (6%)

Query: 16  ACDQGDTETARRLLEPGAAEPAER--GAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVDC 73
           A  +G+T   + LL+ G    A+   G  P   A  +G +         GA     P+  
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-----PLLA 306

Query: 74  SDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDH 133
             + G + L  AA G H   V+ LL+  A V+       +AL  AA  GH  V  LLLD 
Sbjct: 307 RTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDK 366

Query: 134 GADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193
            A+ NA+   G + L +A +   + V++LL++ GA +     SG           P+ + 
Sbjct: 367 RANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL---------TPIHVA 417

Query: 194 ALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDH 253
           A M     GH  +V LL++ GA P+      G + L +AA  G++ V + L+  GA  D 
Sbjct: 418 AFM-----GHLNIVLLLLQNGASPD-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 471

Query: 254 LSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD 313
            +  E+T   +A      ++V  L       P          +  + + G   +   + +
Sbjct: 472 RAREEQTPLHIASRLGKTEIVQLL-LQHMAHPDAATTNGYTPLHISAREGQVDVASVLLE 530

Query: 314 EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNK 373
              +H +L    G TPL +AA  G L + +LL++R A  D     +G T L  A ++ N+
Sbjct: 531 AGAAH-SLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQ 588

Query: 374 EIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           ++   LL +GA     AKNGYT   +    N
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKN 619



 Score =  103 bits (256), Expect = 9e-22
 Identities = 115/422 (27%), Positives = 171/422 (40%), Gaps = 68/422 (16%)

Query: 52  AEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYG 111
           A +AG        V     ++   + G T L  AA   H  +V++LL  GA+ ++    G
Sbjct: 83  ASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG 142

Query: 112 WSALMQAARFGHVSVAHLLL-------------------------------DHGAD---- 136
           ++ L  A + GH     +LL                               DH AD    
Sbjct: 143 FTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSK 202

Query: 137 --VNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQ--------------- 179
             VN     G + L +A+  G++ V  LLL  GA VD    +G                 
Sbjct: 203 MMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVK 262

Query: 180 --LGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALT 235
             L  GG  D      +T L  A + GH+ VV LL+E GA P  A    G SPL +AA  
Sbjct: 263 LLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLLARTKNGLSPLHMAAQG 321

Query: 236 GRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPD 295
             +   + L++  A  D +++   TA  VA  C H  +   L     +  + +   R  +
Sbjct: 322 DHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL-----LDKRANPNARALN 376

Query: 296 IFHALKMG---NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADV 352
            F  L +    N   V E+  +  + +  +   G TP+ +AA  G L +V LL++  A  
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436

Query: 353 DKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVR 412
           D   ++ G TAL  A   G  E+V+ LL  GA V  RA+   T   +   L    TE+V+
Sbjct: 437 D-VTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG--KTEIVQ 493

Query: 413 LL 414
           LL
Sbjct: 494 LL 495



 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 96/341 (28%), Positives = 164/341 (48%), Gaps = 16/341 (4%)

Query: 65  VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV 124
           +G    VD + + GNTAL  A+  G   +V+ L++ GA++N+++  G++ L  AA+  H+
Sbjct: 63  LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122

Query: 125 SVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGG 184
            V   LL++GA+ +     G + L VA + GH   V +LLE         P+   L +  
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPA---LHIAA 179

Query: 185 SRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQL 244
            +D   D  +    +Q+ H A V+  M      N    + G++PL +AA  G + VA  L
Sbjct: 180 RKD---DTKSAALLLQNDHNADVQSKMM----VNRTTES-GFTPLHIAAHYGNVNVATLL 231

Query: 245 VEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRRPDIFHALKMG 303
           + +GA  D  +    T   VA    + ++V   LD    +  KT +      +  A + G
Sbjct: 232 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD--GLTPLHCAARSG 289

Query: 304 NFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTA 363
           + Q+V E+  E  + +     +G +PL +AA    +  V+ L++  A VD   ++   TA
Sbjct: 290 HDQVV-ELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVD-DVTLDYLTA 347

Query: 364 LMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLN 404
           L  A + G+  + K LL++ A+   RA NG+T   +    N
Sbjct: 348 LHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKN 388



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 100/330 (30%), Positives = 147/330 (44%), Gaps = 31/330 (9%)

Query: 69  VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAH 128
           + ++  ++ G  AL  AA  GH  LV+ LL RG+SV+S    G +AL  A+  G   V  
Sbjct: 34  IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 93

Query: 129 LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE 188
           +L+  GA++NAQ++ G + L +A++  H+ VVK LLE GA        G           
Sbjct: 94  VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDG----------- 142

Query: 189 PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKG 248
               T L  A+Q GH   V +L+E     N     V    L +AA       A  L++  
Sbjct: 143 ---FTPLAVALQQGHNQAVAILLE-----NDTKGKVRLPALHIAARKDDTKSAALLLQND 194

Query: 249 ANPDHLSVL-----EKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRR--PDIFHALK 301
            N D  S +      ++ F       H   V+    L       D   R     +  A K
Sbjct: 195 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 254

Query: 302 MGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGW 361
            GN  +VK + D     ++    DG TPL  AA +G   +V+LL+ER A +  + + +G 
Sbjct: 255 RGNTNMVKLLLDRG-GQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGL 312

Query: 362 TALMQATYHGNKEIVKYLLNQGA---DVTL 388
           + L  A    + E VK+LL   A   DVTL
Sbjct: 313 SPLHMAAQGDHVECVKHLLQHKAPVDDVTL 342



 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 89/318 (27%), Positives = 147/318 (46%), Gaps = 27/318 (8%)

Query: 82  LQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQN 141
           L+ A AG  + +V +L + G  +N+ N  G +AL  AA+ GHV +   LL  G+ V++  
Sbjct: 15  LRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSAT 73

Query: 142 RLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQH 201
           + G + L +AS  G   VVK+L++ GA ++    +G               T L  A Q 
Sbjct: 74  KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNG--------------FTPLYMAAQE 119

Query: 202 GHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD------HLS 255
            H  VV+ L+E GA+ + A    G++PL +A   G       L+E            H++
Sbjct: 120 NHIDVVKYLLENGANQSTATED-GFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIA 178

Query: 256 VLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADED 315
             +      AL  ++    D    +   R  T E    P +  A   GN  +   + +  
Sbjct: 179 ARKDDTKSAALLLQNDHNADVQSKMMVNR--TTESGFTP-LHIAAHYGNVNVATLLLNRG 235

Query: 316 PSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEI 375
            + V+    +G TPL +A+  G   +V+LL++R   +D + +  G T L  A   G+ ++
Sbjct: 236 AA-VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK-TRDGLTPLHCAARSGHDQV 293

Query: 376 VKYLLNQGADVTLRAKNG 393
           V+ LL +GA +  R KNG
Sbjct: 294 VELLLERGAPLLARTKNG 311



 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 84/290 (28%), Positives = 136/290 (46%), Gaps = 28/290 (9%)

Query: 113 SALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDH 172
           ++ ++AAR G++      L  G D+N  N+ G + L +A++ GH+G+V+ LL  G+ VD 
Sbjct: 12  ASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS 71

Query: 173 HHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLA 232
               G               TAL  A   G   VV++L++ GA+ N  ++  G++PL +A
Sbjct: 72  ATKKGN--------------TALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMA 116

Query: 233 ALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKR 292
           A    + V + L+E GAN    +    T   VAL   H   V  L     +   T  + R
Sbjct: 117 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL-----LENDTKGKVR 171

Query: 293 RPDIFHALKMGNFQLVKEIADEDPS-------HVNLVNGDGATPLMLAAVTGQLALVQLL 345
            P +  A +  + +    +   D +        VN     G TPL +AA  G + +  LL
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231

Query: 346 VERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           + R A VD   + +G T L  A+  GN  +VK LL++G  +  + ++G T
Sbjct: 232 LNRGAAVD-FTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLT 280



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 91/336 (27%), Positives = 150/336 (44%), Gaps = 45/336 (13%)

Query: 19  QGDTETARRLLEPGAAEP--AERGAEPEAGAEPAG----AEVAGPGAAAAGAVGAPVPVD 72
           +G  + A  LLE GAA     ++G  P   A   G    A++     AAA + G      
Sbjct: 519 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG------ 572

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
              + G T L  AA   ++ +   LL +GAS ++    G++ L  AA+   + +A  LL+
Sbjct: 573 ---KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 629

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDE--- 188
           +GA+ N   + G + L +AS+ GH  +V LLL+ GA +     SG   L L    D+   
Sbjct: 630 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 689

Query: 189 ---------------PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAA 233
                           L  T L+ A  +G+  +V  L++ GA+ N   +  G++PL  AA
Sbjct: 690 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAA 748

Query: 234 LTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLT---TVRPKTDEE 290
             G   +   L++ GA P+  +    TA  +A    +  +VD L  +T   T    T  E
Sbjct: 749 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITE 808

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDG 326
           K + ++   +       V +++DE+    + + GDG
Sbjct: 809 KHKLNVPETMTE-----VLDVSDEEGD--DTMTGDG 837


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  117 bits (292), Expect = 6e-26
 Identities = 98/324 (30%), Positives = 156/324 (48%), Gaps = 18/324 (5%)

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLL 131
           D ++  G TAL  AA  G   +VR LLR GA V++R     + L  A+R G   +  LLL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 132 DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLD 191
            H A  +A    G + L +++R G + V  +LLEAGA     H    + G          
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA----AHSLATKKG---------- 563

Query: 192 ITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
            T L  A ++G   V +LL++  A  + A +  G +PL +AA      VA  L+EKGA+P
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 252 DHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEI 311
              +    T   +A       +   L           ++   P +  A + G+  +V  +
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP-LHLASQEGHTDMVTLL 681

Query: 312 ADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHG 371
            D+  +++++    G T L LAA   ++ +  +L +  AD D    + G+T L+ A ++G
Sbjct: 682 LDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYG 739

Query: 372 NKEIVKYLLNQGADVTLRAKNGYT 395
           N ++V +LL QGA+V  + KNGYT
Sbjct: 740 NVKMVNFLLKQGANVNAKTKNGYT 763



 Score =  110 bits (275), Expect = 6e-24
 Identities = 104/366 (28%), Positives = 159/366 (43%), Gaps = 49/366 (13%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D     G T L  AA  GH+ +V  LL RGA + +R   G S L  AA+  HV     L
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L H A V+       + L VA+  GH  V KLLL+  A     +P+   L          
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA-----NPNARALN--------- 397

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
             T L  A +     V+ LL+++GA    A    G +P+ +AA  G L +   L++ GA+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLV-- 308
           PD  ++  +TA  +A      ++V  L     +      E++ P +  A ++G  ++V  
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP-LHIASRLGKTEIVQL 515

Query: 309 --KEIADED--------PSHVNLVNGD--------------------GATPLMLAAVTGQ 338
             + +A  D        P H++   G                     G TPL +AA  G 
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575

Query: 339 LALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFD 398
           L + +LL++R A  D     +G T L  A ++ N+++   LL +GA     AKNGYT   
Sbjct: 576 LDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634

Query: 399 LVMLLN 404
           +    N
Sbjct: 635 IAAKKN 640



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 106/367 (28%), Positives = 161/367 (43%), Gaps = 31/367 (8%)

Query: 32  GAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHE 91
           G+++  +R  + ++ A    A  AG        +   + ++  ++ G  AL  AA  GH 
Sbjct: 18  GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHV 77

Query: 92  PLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVA 151
            LV+ LL RG+SV+S    G +AL  A+  G   V  +L+  GA++NAQ++ G + L +A
Sbjct: 78  GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137

Query: 152 SRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM 211
           ++  H+ VVK LLE GA        G               T L  A+Q GH   V +L+
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDG--------------FTPLAVALQQGHNQAVAILL 183

Query: 212 EWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVL-----EKTAFEVAL 266
           E     N     V    L +AA       A  L++   N D  S +      ++ F    
Sbjct: 184 E-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH 238

Query: 267 DCKHRDLVDYLDPLTTVRPKTDEEKRR--PDIFHALKMGNFQLVKEIADEDPSHVNLVNG 324
              H   V+    L       D   R     +  A K GN  +VK + D     ++    
Sbjct: 239 IAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG-GQIDAKTR 297

Query: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
           DG TPL  AA +G   +V+LL+ER A +  + + +G + L  A    + E VK+LL   A
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVECVKHLLQHKA 356

Query: 385 ---DVTL 388
              DVTL
Sbjct: 357 PVDDVTL 363



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 91/336 (27%), Positives = 150/336 (44%), Gaps = 45/336 (13%)

Query: 19  QGDTETARRLLEPGAAEP--AERGAEPEAGAEPAG----AEVAGPGAAAAGAVGAPVPVD 72
           +G  + A  LLE GAA     ++G  P   A   G    A++     AAA + G      
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG------ 593

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
              + G T L  AA   ++ +   LL +GAS ++    G++ L  AA+   + +A  LL+
Sbjct: 594 ---KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDE--- 188
           +GA+ N   + G + L +AS+ GH  +V LLL+ GA +     SG   L L    D+   
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 189 ---------------PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAA 233
                           L  T L+ A  +G+  +V  L++ GA+ N   +  G++PL  AA
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAA 769

Query: 234 LTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLT---TVRPKTDEE 290
             G   +   L++ GA P+  +    TA  +A    +  +VD L  +T   T    T  E
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITE 829

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDG 326
           K + ++   +       V +++DE+    + + GDG
Sbjct: 830 KHKLNVPETMTE-----VLDVSDEEGD--DTMTGDG 858



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 81/302 (26%), Positives = 131/302 (43%), Gaps = 49/302 (16%)

Query: 113 SALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDH 172
           ++ ++AAR G++      L  G D+N  N+ G + L +A++ GH+G+V+ LL  G+ VD 
Sbjct: 33  ASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS 92

Query: 173 HHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLA 232
               G               TAL  A   G   VV++L++ GA+ N  ++  G++PL +A
Sbjct: 93  ATKKGN--------------TALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMA 137

Query: 233 ALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKR 292
           A    + V + L+E GAN    +    T   VAL   H   V  L     +   T  + R
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL-----LENDTKGKVR 192

Query: 293 RPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADV 352
            P +  A +  + +    +   D       N D  + +M+   T                
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDH------NADVQSKMMVNRTTES-------------- 232

Query: 353 DKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVR 412
                  G+T L  A ++GN  +   LLN+GA V   A+NG T   L +     +T +V+
Sbjct: 233 -------GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT--PLHVASKRGNTNMVK 283

Query: 413 LL 414
           LL
Sbjct: 284 LL 285



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 42/131 (32%), Positives = 64/131 (48%), Gaps = 6/131 (4%)

Query: 284 RPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQ 343
           RPK  +         A + GN   V E   +    +N  N +G   L LAA  G + LVQ
Sbjct: 25  RPKKSDSNA--SFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQ 81

Query: 344 LLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLL 403
            L+ R + VD      G TAL  A+  G  E+VK L+ +GA++  +++NG+T   L M  
Sbjct: 82  ELLGRGSSVDSATK-KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT--PLYMAA 138

Query: 404 NDPDTELVRLL 414
            +   ++V+ L
Sbjct: 139 QENHIDVVKYL 149


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  117 bits (292), Expect = 6e-26
 Identities = 98/324 (30%), Positives = 156/324 (48%), Gaps = 18/324 (5%)

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLL 131
           D ++  G TAL  AA  G   +VR LLR GA V++R     + L  A+R G   +  LLL
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517

Query: 132 DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLD 191
            H A  +A    G + L +++R G + V  +LLEAGA     H    + G          
Sbjct: 518 QHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGA----AHSLATKKG---------- 563

Query: 192 ITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
            T L  A ++G   V +LL++  A  + A +  G +PL +AA      VA  L+EKGA+P
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKN-GLTPLHVAAHYDNQKVALLLLEKGASP 622

Query: 252 DHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEI 311
              +    T   +A       +   L           ++   P +  A + G+  +V  +
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTP-LHLASQEGHTDMVTLL 681

Query: 312 ADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHG 371
            D+  +++++    G T L LAA   ++ +  +L +  AD D    + G+T L+ A ++G
Sbjct: 682 LDKG-ANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKL-GYTPLIVACHYG 739

Query: 372 NKEIVKYLLNQGADVTLRAKNGYT 395
           N ++V +LL QGA+V  + KNGYT
Sbjct: 740 NVKMVNFLLKQGANVNAKTKNGYT 763



 Score =  110 bits (275), Expect = 6e-24
 Identities = 104/366 (28%), Positives = 159/366 (43%), Gaps = 49/366 (13%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D     G T L  AA  GH+ +V  LL RGA + +R   G S L  AA+  HV     L
Sbjct: 292 IDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHL 351

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L H A V+       + L VA+  GH  V KLLL+  A     +P+   L          
Sbjct: 352 LQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA-----NPNARALN--------- 397

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
             T L  A +     V+ LL+++GA    A    G +P+ +AA  G L +   L++ GA+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGAS-IQAITESGLTPIHVAAFMGHLNIVLLLLQNGAS 456

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLV-- 308
           PD  ++  +TA  +A      ++V  L     +      E++ P +  A ++G  ++V  
Sbjct: 457 PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTP-LHIASRLGKTEIVQL 515

Query: 309 --KEIADED--------PSHVNLVNGD--------------------GATPLMLAAVTGQ 338
             + +A  D        P H++   G                     G TPL +AA  G 
Sbjct: 516 LLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGS 575

Query: 339 LALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFD 398
           L + +LL++R A  D     +G T L  A ++ N+++   LL +GA     AKNGYT   
Sbjct: 576 LDVAKLLLQRRAAADSAGK-NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLH 634

Query: 399 LVMLLN 404
           +    N
Sbjct: 635 IAAKKN 640



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 106/367 (28%), Positives = 161/367 (43%), Gaps = 31/367 (8%)

Query: 32  GAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHE 91
           G+++  +R  + ++ A    A  AG        +   + ++  ++ G  AL  AA  GH 
Sbjct: 18  GSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHV 77

Query: 92  PLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVA 151
            LV+ LL RG+SV+S    G +AL  A+  G   V  +L+  GA++NAQ++ G + L +A
Sbjct: 78  GLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMA 137

Query: 152 SRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM 211
           ++  H+ VVK LLE GA        G               T L  A+Q GH   V +L+
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDG--------------FTPLAVALQQGHNQAVAILL 183

Query: 212 EWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVL-----EKTAFEVAL 266
           E     N     V    L +AA       A  L++   N D  S +      ++ F    
Sbjct: 184 E-----NDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLH 238

Query: 267 DCKHRDLVDYLDPLTTVRPKTDEEKRR--PDIFHALKMGNFQLVKEIADEDPSHVNLVNG 324
              H   V+    L       D   R     +  A K GN  +VK + D     ++    
Sbjct: 239 IAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG-GQIDAKTR 297

Query: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
           DG TPL  AA +G   +V+LL+ER A +  + + +G + L  A    + E VK+LL   A
Sbjct: 298 DGLTPLHCAARSGHDQVVELLLERGAPLLAR-TKNGLSPLHMAAQGDHVECVKHLLQHKA 356

Query: 385 ---DVTL 388
              DVTL
Sbjct: 357 PVDDVTL 363



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 91/336 (27%), Positives = 150/336 (44%), Gaps = 45/336 (13%)

Query: 19  QGDTETARRLLEPGAAEP--AERGAEPEAGAEPAG----AEVAGPGAAAAGAVGAPVPVD 72
           +G  + A  LLE GAA     ++G  P   A   G    A++     AAA + G      
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG------ 593

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
              + G T L  AA   ++ +   LL +GAS ++    G++ L  AA+   + +A  LL+
Sbjct: 594 ---KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLN 650

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG-EQLGLGGSRDE--- 188
           +GA+ N   + G + L +AS+ GH  +V LLL+ GA +     SG   L L    D+   
Sbjct: 651 YGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNV 710

Query: 189 ---------------PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAA 233
                           L  T L+ A  +G+  +V  L++ GA+ N   +  G++PL  AA
Sbjct: 711 ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKN-GYTPLHQAA 769

Query: 234 LTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLT---TVRPKTDEE 290
             G   +   L++ GA P+  +    TA  +A    +  +VD L  +T   T    T  E
Sbjct: 770 QQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITE 829

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDG 326
           K + ++   +       V +++DE+    + + GDG
Sbjct: 830 KHKLNVPETMTE-----VLDVSDEEGD--DTMTGDG 858



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 81/302 (26%), Positives = 131/302 (43%), Gaps = 49/302 (16%)

Query: 113 SALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDH 172
           ++ ++AAR G++      L  G D+N  N+ G + L +A++ GH+G+V+ LL  G+ VD 
Sbjct: 33  ASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS 92

Query: 173 HHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLA 232
               G               TAL  A   G   VV++L++ GA+ N  ++  G++PL +A
Sbjct: 93  ATKKGN--------------TALHIASLAGQAEVVKVLVKEGANINAQSQN-GFTPLYMA 137

Query: 233 ALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKR 292
           A    + V + L+E GAN    +    T   VAL   H   V  L     +   T  + R
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAIL-----LENDTKGKVR 192

Query: 293 RPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADV 352
            P +  A +  + +    +   D       N D  + +M+   T                
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDH------NADVQSKMMVNRTTES-------------- 232

Query: 353 DKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVR 412
                  G+T L  A ++GN  +   LLN+GA V   A+NG T   L +     +T +V+
Sbjct: 233 -------GFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGIT--PLHVASKRGNTNMVK 283

Query: 413 LL 414
           LL
Sbjct: 284 LL 285



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 42/131 (32%), Positives = 64/131 (48%), Gaps = 6/131 (4%)

Query: 284 RPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQ 343
           RPK  +         A + GN   V E   +    +N  N +G   L LAA  G + LVQ
Sbjct: 25  RPKKSDSNA--SFLRAARAGNLDKVVEYL-KGGIDINTCNQNGLNALHLAAKEGHVGLVQ 81

Query: 344 LLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLL 403
            L+ R + VD      G TAL  A+  G  E+VK L+ +GA++  +++NG+T   L M  
Sbjct: 82  ELLGRGSSVDSATK-KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFT--PLYMAA 138

Query: 404 NDPDTELVRLL 414
            +   ++V+ L
Sbjct: 139 QENHIDVVKYL 149



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 23/90 (25%), Positives = 40/90 (44%), Gaps = 4/90 (4%)

Query: 672  RKKAAGLLEQKPSHRSSPVGPAPGSSPSELPASPAGGS---APVGKKLETSKRPPSGTST 728
            R K    + +K +HR  P       S    P SP+  +   + +    +T + PP   S+
Sbjct: 1790 RVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSS 1849

Query: 729  TSKSTSPTLTPSPSPKGHTAESSVSSSSSH 758
             ++  SP ++PS   + H+  SS S +  H
Sbjct: 1850 KTEKHSP-VSPSAKTERHSPASSSSKTEKH 1878



 Score = 30.4 bits (67), Expect = 7.4
 Identities = 28/127 (22%), Positives = 48/127 (37%), Gaps = 20/127 (15%)

Query: 683  PSHRSSPVGP-APGSSPSELPASPAGGS---------------APVGKKLETSKRPPSGT 726
            PS R+    P +PG +   LP SP+G +                PV    +T K+PP   
Sbjct: 1918 PSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSP 1977

Query: 727  STTSKSTSPTLTPSPSPKGHTAESSVSSSSS----HRQSKSSGGSSSGTITDEDELTGIL 782
            ++ ++    T++     K   +    S   +    H+ +K       G +  E E   IL
Sbjct: 1978 TSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQEKGKVRVEKEKGPIL 2037

Query: 783  KKLSLEK 789
             +   +K
Sbjct: 2038 TQREAQK 2044


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  113 bits (282), Expect = 9e-25
 Identities = 106/376 (28%), Positives = 168/376 (44%), Gaps = 30/376 (7%)

Query: 65  VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVN----------SRNHYGWSA 114
           +G  V     +  G  AL +AA  GHE  VR LL   A+V+          +R  +G +A
Sbjct: 35  IGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNA 94

Query: 115 LMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHH 174
           L+ +A FGH+ +  +L++ GA ++ +++ G ++L  A++ GH+ V+  ++E    V   H
Sbjct: 95  LLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMEDLEDVALDH 154

Query: 175 PSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAAL 234
                        + L  TA   A +HG    +  L+  G D N   +  G + L LAA 
Sbjct: 155 V------------DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKE-GNTALHLAAG 201

Query: 235 TGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVD-YLDPLTTVRPKTDEEKRR 293
            G + V Q+LV+ G + +  +    TA   A    H D V   L   +TV   T   ++ 
Sbjct: 202 RGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALT---QKN 258

Query: 294 PDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
               H   +   + V  +        N+V+  GA+PL LA      ALV+LL+   +DV+
Sbjct: 259 LSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVN 318

Query: 354 KQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRL 413
             D+    T L  A  H  ++I   LL  G D+ LR K G TA  L + +      LV +
Sbjct: 319 AVDN-RQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTA--LAVAVRSNHVSLVDM 375

Query: 414 LASVCMQVNKDKGRPS 429
           +         +K  PS
Sbjct: 376 IIKADRFYRWEKDHPS 391



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 82/316 (25%), Positives = 131/316 (41%), Gaps = 47/316 (14%)

Query: 115 LMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHH 174
           L +AAR  +V     L+    +  A+N +G   L  A+  GH   V+LLLE  A VD   
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVD--- 75

Query: 175 PSGEQLGLGGSRDEPL--DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLA 232
              E+  +G   +  L   + AL+ +   GH  ++++L+  GA   H     G + L  A
Sbjct: 76  ---EEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGA-KIHCESKDGLTLLHCA 131

Query: 233 ALTGRLGVAQQLVE--KGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEE 290
           A  G + V   ++E  +    DH+  L +TAF  A +    D +D+L     V    D  
Sbjct: 132 AQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFL-----VGSGCDH- 185

Query: 291 KRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHA 350
                                        N+ + +G T L LAA  G +A++Q LV+   
Sbjct: 186 -----------------------------NVKDKEGNTALHLAAGRGHMAVLQRLVDIGL 216

Query: 351 DVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
           D+++Q++  G TAL  A    + + V+ LL  G+ V    +   +      L    D   
Sbjct: 217 DLEEQNA-EGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 275

Query: 411 VRLLASVCMQVNKDKG 426
           V + A  C  V   +G
Sbjct: 276 VLIHAGGCANVVDHQG 291



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 5/111 (4%)

Query: 75  DEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHG 134
           D  G + L  A       LVR L+   + VN+ ++   + L  AA      +A +LL  G
Sbjct: 288 DHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAG 347

Query: 135 ADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFV----DH-HHPSGEQL 180
            D+N +++ G + L VA R  H+ +V ++++A  F     DH   PSG+ L
Sbjct: 348 VDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSL 398


>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
           sapiens]
          Length = 1771

 Score =  110 bits (274), Expect = 7e-24
 Identities = 100/326 (30%), Positives = 150/326 (46%), Gaps = 51/326 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           VD  +E G T L  AA  G+  +V+ L++ GA+ N  +   W+AL+ A++ GHV +   L
Sbjct: 31  VDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEEL 90

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L  G ++  ++  G + L  A   G   VV+LLL  GA     +PS   L          
Sbjct: 91  LKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA-----NPSVTGL---------Y 136

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
            +  ++ A   GH  +V LL++ GA  N  +   G +PL+ AA  G L   + L+  GA+
Sbjct: 137 SVYPIIWAAGRGHADIVHLLLQNGAKVN-CSDKYGTTPLVWAARKGHLECVKHLLAMGAD 195

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKE 310
            D       TA  V                                  A+K G  Q VKE
Sbjct: 196 VDQEGANSMTALIV----------------------------------AVKGGYTQSVKE 221

Query: 311 IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYH 370
           I   +P +VNL + DG T LM+A+  G   +VQ L++    V+  D   G T L+ A   
Sbjct: 222 ILKRNP-NVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDR-SGDTVLIGAVRG 279

Query: 371 GNKEIVKYLLNQGADVTLRAKNGYTA 396
           G+ EIV+ LL + AD+ +R ++  TA
Sbjct: 280 GHVEIVRALLQKYADIDIRGQDNKTA 305



 Score =  103 bits (256), Expect = 9e-22
 Identities = 96/375 (25%), Positives = 170/375 (45%), Gaps = 25/375 (6%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVPVD 72
           L+ A +QG+ E  + L++ GA    E   + +       A   G        +   V ++
Sbjct: 42  LMIAAEQGNLEIVKELIKNGANCNLE---DLDNWTALISASKEGHVHIVEELLKCGVNLE 98

Query: 73  CSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLD 132
             D  G TAL +A   G   +V  LL  GA+ +    Y    ++ AA  GH  + HLLL 
Sbjct: 99  HRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLLLQ 158

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
           +GA VN  ++ G + L  A+R GHL  VK LL  GA VD    +               +
Sbjct: 159 NGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGAN--------------SM 204

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD 252
           TAL+ A++ G+   V+ +++   + N   +  G + LM+A+  G   + Q L++ G    
Sbjct: 205 TALIVAVKGGYTQSVKEILKRNPNVNLTDKD-GNTALMIASKEGHTEIVQDLLDAGT--- 260

Query: 253 HLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTD--EEKRRPDIFHALKMGNFQLVKE 310
           ++++ +++   V +       V+ +  L       D   +  +  ++ A++ GN  +V++
Sbjct: 261 YVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRD 320

Query: 311 IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYH 370
           I   +P    +   DG TPL+ A     + +V+LL+++ A V   D   G T L  A   
Sbjct: 321 ILQCNPD-TEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK-KGDTPLHIAIRG 378

Query: 371 GNKEIVKYLLNQGAD 385
            ++++ + LL    D
Sbjct: 379 RSRKLAELLLRNPKD 393


>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
          Length = 301

 Score =  103 bits (258), Expect = 5e-22
 Identities = 74/205 (36%), Positives = 107/205 (52%), Gaps = 24/205 (11%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++   E+G TAL FAA  GH  +VRFL   GAS   R   G +AL+ A+++GH+ V   L
Sbjct: 72  INLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETL 131

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L HGA+++ Q   GA+ L +A++GG+L V++LLL +GA V+     G             
Sbjct: 132 LKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDG------------- 178

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQL------ 244
               L  A Q GH  VVR+++  GAD   AAR  G + L+ AA  G   V ++L      
Sbjct: 179 -TAPLWIASQMGHSEVVRVMLLRGAD-RDAARNDGTTALLKAANKGYNDVIKELLKFSPT 236

Query: 245 ---VEKGANPDHLSVLEKTAFEVAL 266
              ++ G +  H +VL      VAL
Sbjct: 237 LGILKNGTSALHAAVLSGNIKTVAL 261



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 82/273 (30%), Positives = 122/273 (44%), Gaps = 27/273 (9%)

Query: 84  FAAAGGHEPLVRFLLRRG-ASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNR 142
           +AA  G+  L++ LL  G   V+ R+ +G + LM AA  GH+     L+  GAD+N Q  
Sbjct: 18  WAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77

Query: 143 LGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHG 202
            G + L  A++ GH  VV+ L   GA  +     G               TAL+AA Q+G
Sbjct: 78  SGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGG--------------TALLAASQYG 123

Query: 203 HEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAF 262
           H  VV  L++ GA+  H     G + L LAA  G L V + L+  GA  +          
Sbjct: 124 HMQVVETLLKHGAN-IHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPL 182

Query: 263 EVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPD----IFHALKMGNFQLVKEIADEDPSH 318
            +A    H ++V  +     +    D +  R D    +  A   G   ++KE+    P+ 
Sbjct: 183 WIASQMGHSEVVRVM-----LLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTL 237

Query: 319 VNLVNGDGATPLMLAAVTGQLALVQLLVERHAD 351
             L NG  A  L  A ++G +  V LL+E  AD
Sbjct: 238 GILKNGTSA--LHAAVLSGNIKTVALLLEAGAD 268



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 64/215 (29%), Positives = 102/215 (47%), Gaps = 12/215 (5%)

Query: 186 RDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLV 245
           ++ PL   A  AA + G+ A+++LL+  G        + G + LM+AA  G +   ++LV
Sbjct: 8   KETPLANAAFWAA-RRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELV 66

Query: 246 EKGANPDHLSVLEKTAFEVALDCKHRDLVDYL---DPLTTVRPKTDEEKRRPDIFHALKM 302
            +GA+ +       TA   A    H D+V +L      T  R K         +  A + 
Sbjct: 67  LQGADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTA----LLAASQY 122

Query: 303 GNFQLVKEIADEDPS-HVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGW 361
           G+ Q+V+ +     + H  L   DGAT L LAA  G L +++LL+   A V+ Q    G 
Sbjct: 123 GHMQVVETLLKHGANIHDQLY--DGATALFLAAQGGYLDVIRLLLASGAKVN-QPRQDGT 179

Query: 362 TALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTA 396
             L  A+  G+ E+V+ +L +GAD      +G TA
Sbjct: 180 APLWIASQMGHSEVVRVMLLRGADRDAARNDGTTA 214



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 35/83 (42%), Positives = 49/83 (59%), Gaps = 4/83 (4%)

Query: 333 AAVTGQLALVQLLVER-HADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAK 391
           AA  G LAL++LL+     DVD +DS HG T LM A Y G+ + V+ L+ QGAD+ L+ +
Sbjct: 19  AARRGNLALLKLLLNSGRVDVDCRDS-HGTTLLMVAAYAGHIDCVRELVLQGADINLQRE 77

Query: 392 NGYTAFDLVMLLNDPDTELVRLL 414
           +G TA  L         ++VR L
Sbjct: 78  SGTTA--LFFAAQQGHNDVVRFL 98



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 42/161 (26%), Positives = 73/161 (45%), Gaps = 34/161 (21%)

Query: 297 FHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQ- 355
           F A + GN  L+K + +     V+  +  G T LM+AA  G +  V+ LV + AD++ Q 
Sbjct: 17  FWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINLQR 76

Query: 356 ----------------DSVH---------------GWTALMQATYHGNKEIVKYLLNQGA 384
                           D V                G TAL+ A+ +G+ ++V+ LL  GA
Sbjct: 77  ESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHGA 136

Query: 385 DVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDK 425
           ++  +  +G TA  L +       +++RLL +   +VN+ +
Sbjct: 137 NIHDQLYDGATA--LFLAAQGGYLDVIRLLLASGAKVNQPR 175


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  103 bits (257), Expect = 7e-22
 Identities = 100/344 (29%), Positives = 147/344 (42%), Gaps = 59/344 (17%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+ SD AG TAL  AA  GH  +V+ LL RGA++N+ +     A+  AA  GH+ V  LL
Sbjct: 133 VNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLL 192

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGE---QLGLGGSRD 187
           + HGA+V  +++   + L  A+  G + VVK LL+ G  ++  +  G     +     +D
Sbjct: 193 VSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQD 252

Query: 188 ----EPLDITALM--------------AAIQHGHEAVVRLLMEWGADPNHAARTVGWSPL 229
               E +D  A++              AA  HG    + LL+  GAD N  ++  G +PL
Sbjct: 253 VVVNELIDCGAIVNQKNEKGFTPLHFAAASTHG-ALCLELLVGNGADVNMKSKD-GKTPL 310

Query: 230 MLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDE 289
            + AL GR   +Q +++ GA  D       T   +A    H  L++     T +    D 
Sbjct: 311 HMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLIN-----TLITSGADT 365

Query: 290 EKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERH 349
            KR                                 G  PL LAA++G     + L+   
Sbjct: 366 AKR------------------------------GIHGMFPLHLAALSGFSDCCRKLLSSG 395

Query: 350 ADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNG 393
            D+D  D   G T L  A   GN E +  LLN GAD   + K G
Sbjct: 396 FDIDTPDD-FGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFG 438



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 87/339 (25%), Positives = 144/339 (42%), Gaps = 37/339 (10%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           VD  D  G T L  +   GH   V  LL +GA+V++++ +G +AL + A  GH      L
Sbjct: 646 VDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDAL 705

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           L HGA    ++  G + + +++  GH+GV+  LL++ A +D +  + +  G         
Sbjct: 706 LQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG--------- 756

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE---- 246
             TAL  A  +GHE  V LL+E   +         +SPL  A +    G A+ L++    
Sbjct: 757 -YTALHWACYNGHETCVELLLE--QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGA 813

Query: 247 --------KGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFH 298
                   KG  P H +        + L   H   V+ +D              +  +  
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVD-----------STGKTPLMM 862

Query: 299 ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSV 358
           A + G    V+ +     + + L +    T L LA   G      L++E+  D +  ++ 
Sbjct: 863 AAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINAT 922

Query: 359 HG--WTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           +    T L  A  +G   +V+ LL +GA V    +NGYT
Sbjct: 923 NAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961



 Score = 94.4 bits (233), Expect = 4e-19
 Identities = 93/334 (27%), Positives = 152/334 (45%), Gaps = 21/334 (6%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+  D    T L  A A   E  V+ LL+  A VN+R+    + L  AA    V  A  L
Sbjct: 67  VNAKDSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           +   ++VN  +R G + L  A+  GH  +VKLLL  GA ++                +  
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAF--------------DKK 172

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
           D  A+  A   GH  VV+LL+  GA+     +   ++PL  AA +G + V + L++ G +
Sbjct: 173 DRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKK-SYTPLHAAASSGMISVVKYLLDLGVD 231

Query: 251 PDHLSVLEKTAFEVALDCKHRDLV--DYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLV 308
            +  +    T   VA     +D+V  + +D    V  K   EK    +  A    +  L 
Sbjct: 232 MNEPNAYGNTPLHVAC-YNGQDVVVNELIDCGAIVNQK--NEKGFTPLHFAAASTHGALC 288

Query: 309 KEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQAT 368
            E+   + + VN+ + DG TPL + A+ G+ +  Q +++  A +D +D  +G T L  A 
Sbjct: 289 LELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDK-NGNTPLHIAA 347

Query: 369 YHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVML 402
            +G++ ++  L+  GAD   R  +G     L  L
Sbjct: 348 RYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381



 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 99/343 (28%), Positives = 151/343 (44%), Gaps = 29/343 (8%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           +D  D+ G T L  AAAGG+   +  LL  GA  N ++ +G S L  AA   +      L
Sbjct: 398 IDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFAL 457

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLG-VVKLLLEAGAFVDHHHPSGEQLGLGGSRDEP 189
           +  GA VN  +  G + L  A+     G  ++ LL   A     +P        G RD+ 
Sbjct: 458 VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDA-----NP--------GIRDKQ 504

Query: 190 LDITALMAAIQHGHEAVVRL---------LMEW-GADP-NHAARTVGWSPLMLAALTGRL 238
               A+  +  +GH   ++L         LME  G D  + +      SPL LAA  G  
Sbjct: 505 -GYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHH 563

Query: 239 GVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFH 298
              + LV+   + D  +   +T  ++A    H + VD L          D   +R  I  
Sbjct: 564 QALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHA 623

Query: 299 ALKMGNFQLVK-EIADEDPSH-VNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQD 356
           A   G+ + ++  I + +P + V++ +G+G TPLML+ + G    V  L+ + A+VD +D
Sbjct: 624 AATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKD 683

Query: 357 SVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDL 399
              G TAL +    G++E V  LL  GA   LR   G T   L
Sbjct: 684 K-WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 92/357 (25%), Positives = 150/357 (42%), Gaps = 75/357 (21%)

Query: 65  VGAPVPVDCSDEAGNTALQFAAAGGHE-PLVRFLLRRGASVNSRNHYGWSALMQAARFGH 123
           VG+   V+  DE G T L +AA    +   + +LLR  A+   R+  G++A+  +A +GH
Sbjct: 458 VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH 517

Query: 124 VSVAHLLLDH----------GADV--NAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVD 171
                L+             G D+  ++ NR   S L +A+  GH   +++L+++   +D
Sbjct: 518 RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD 577

Query: 172 HHHPSGEQ-----------------LGLGGS---RDEPLDITALMAAIQHGHEAVVRLLM 211
             + SG                   +  G S   +D  L  T + AA  +GH   +RLL+
Sbjct: 578 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLI 637

Query: 212 EWGADPNHAARTV---GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDC 268
              A+P +A       G +PLML+ L G       L+ KGAN D      +TA       
Sbjct: 638 -GNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT 696

Query: 269 KHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGAT 328
            H + VD L                      L+ G   L+++               G T
Sbjct: 697 GHEECVDAL----------------------LQHGAKCLLRD-------------SRGRT 721

Query: 329 PLMLAAVTGQLALVQLLVERHADVDKQDSV---HGWTALMQATYHGNKEIVKYLLNQ 382
           P+ L+A  G + ++  L++  A +D   +    HG+TAL  A Y+G++  V+ LL Q
Sbjct: 722 PIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 98/340 (28%), Positives = 145/340 (42%), Gaps = 30/340 (8%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHY-GWSALMQAARFGHVSVAHL 129
           +D  + +G T L  AA  GH   V  L+ +GAS+  +++    + +  AA  GH     L
Sbjct: 576 LDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL 635

Query: 130 LLDHGADVNA---QNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSR 186
           L+ +    NA   Q+  G + L ++   GH   V  LL  GA VD     G         
Sbjct: 636 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGR-------- 687

Query: 187 DEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVE 246
                 TAL      GHE  V  L++ GA       + G +P+ L+A  G +GV   L++
Sbjct: 688 ------TALHRGAVTGHEECVDALLQHGAKCL-LRDSRGRTPIHLSAACGHIGVLGALLQ 740

Query: 247 KGA----NPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKM 302
             A    NP        TA   A    H   V+ L     V  KT+     P   H   +
Sbjct: 741 SAASMDANPATADNHGYTALHWACYNGHETCVELLLE-QEVFQKTEGNAFSP--LHCAVI 797

Query: 303 GNFQLVKEIADED--PSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHG 360
            + +   E+  +    S VN  +  G TPL  AA T  +  +QLL+  +A V+  DS  G
Sbjct: 798 NDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDST-G 856

Query: 361 WTALMQATYHGNKEIVKYLLNQ-GADVTLRAKNGYTAFDL 399
            T LM A  +G    V+ L++   A++TL+  +  TA  L
Sbjct: 857 KTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHL 896



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 76/283 (26%), Positives = 132/283 (46%), Gaps = 20/283 (7%)

Query: 114 ALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHH 173
           +L+QA   G       L+    DVN Q+    + L  A+  G   +++LL+ +GA V+  
Sbjct: 11  SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVN-- 68

Query: 174 HPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGW-SPLMLA 232
                      ++D    +T L  A+    E  V++L++  AD N  AR   W +PL +A
Sbjct: 69  -----------AKDSKW-LTPLHRAVASCSEEAVQVLLKHSADVN--ARDKNWQTPLHIA 114

Query: 233 ALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKR 292
           A    +  A+ LV   +N +      +TA   A    H ++V  L          D++ R
Sbjct: 115 AANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDR 174

Query: 293 RPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADV 352
           R  I  A  MG+ ++VK +     + V   +    TPL  AA +G +++V+ L++   D+
Sbjct: 175 RA-IHWAAYMGHIEVVKLLVSHG-AEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232

Query: 353 DKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           + + + +G T L  A Y+G   +V  L++ GA V  + + G+T
Sbjct: 233 N-EPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFT 274



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 94/361 (26%), Positives = 141/361 (39%), Gaps = 64/361 (17%)

Query: 13   LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
            L R    G  E    LL+ GA       RG  P   +   G  +   GA    A      
Sbjct: 690  LHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACG-HIGVLGALLQSAASMDAN 748

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRR------------------------------ 100
               +D  G TAL +A   GHE  V  LL +                              
Sbjct: 749  PATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLI 808

Query: 101  ---GAS-VNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGH 156
               GAS VN+ +  G + L  AA   HV    LLL H A VN+ +  G + L +A+  G 
Sbjct: 809  DTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQ 868

Query: 157  LGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGAD 216
               V++L+ +         S E      S++     TAL  A   GHE    L++E   D
Sbjct: 869  TNTVEMLVSSA--------SAELTLQDNSKN-----TALHLACSKGHETSALLILEKITD 915

Query: 217  PN--HAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDC-KHRDL 273
             N  +A      +PL +AA  G   V Q+L+ KGA+   +  +++  +  AL C  ++D+
Sbjct: 916  RNLINATNAALQTPLHVAARNGLTMVVQELLGKGAS---VLAVDENGYTPALACAPNKDV 972

Query: 274  VDYLD-PLTTVRPKTDEEKRRPDIFHAL-------KMGNFQLVKEIADEDPSHVNLVNGD 325
             D L   L T+ P +         F+A+       K  +F+ +  + +E  S+ +  N  
Sbjct: 973  ADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPSSYCSFNNIG 1032

Query: 326  G 326
            G
Sbjct: 1033 G 1033


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  102 bits (254), Expect = 2e-21
 Identities = 112/390 (28%), Positives = 168/390 (43%), Gaps = 54/390 (13%)

Query: 34  AEPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPV--PVDCSDEAGNTALQFAAAGGHE 91
           A  A+  A  +    P     A      A A+ AP+   ++ +D +G +AL  A   GH 
Sbjct: 95  AHSADVNARDKLWQTPLHVAAANRATKCAEAL-APLLSSLNVADRSGRSALHHAVHSGHL 153

Query: 92  PLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVA 151
             V  LL +GAS+N  +      L  AA  GH+ V  LL+  GAD+  ++R G  +L  A
Sbjct: 154 ETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTA 213

Query: 152 SRGGHLGVVKLLLEAGAFVDHHHPSG-----------------EQLGLGGSRDEPLD--I 192
           +  G + VVK LL  GA +D  +  G                 E +  G + ++P D   
Sbjct: 214 AASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGF 273

Query: 193 TAL-MAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANP 251
           T L +AA+       + LL+  GAD N+ ++  G SPL +AA+ GR   +Q L++ G+  
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKE-GKSPLHMAAIHGRFTRSQILIQNGSEI 332

Query: 252 DHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEI 311
           D       T   VA    H  L+      T +    D  +R                  I
Sbjct: 333 DCADKFGNTPLHVAARYGHELLIS-----TLMTNGADTARR-----------------GI 370

Query: 312 ADEDPSHVNLVNGDGATPLMLAAVTGQL-ALVQLLVERHA-----DVDKQDSVHGWTALM 365
            D  P H+ ++ G       L + +GQL ++V  L   H      D++  D++ G T L 
Sbjct: 371 HDMFPLHLAVLFGFSDCCRKLLS-SGQLYSIVSSLSNEHVLSAGFDINTPDNL-GRTCLH 428

Query: 366 QATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
            A   GN E +  LL+ GAD+  R K G T
Sbjct: 429 AAASGGNVECLNLLLSSGADLRRRDKFGRT 458



 Score = 94.7 bits (234), Expect = 3e-19
 Identities = 99/374 (26%), Positives = 156/374 (41%), Gaps = 58/374 (15%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           ++  D+   T L  AA  G  P+++ LL  GA+VN+++    + L +AA   +  V  LL
Sbjct: 34  INVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLL 93

Query: 131 LDHGADVNAQNRL---------------------------------GASVLTVASRGGHL 157
           L H ADVNA+++L                                 G S L  A   GHL
Sbjct: 94  LAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHL 153

Query: 158 GVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADP 217
             V LLL  GA ++       Q         PL   A +     GH  V++LL+  GAD 
Sbjct: 154 ETVNLLLNKGASLNVCDKKERQ---------PLHWAAFL-----GHLEVLKLLVARGADL 199

Query: 218 NHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVAL----DCKHRDL 273
               R  G+  L  AA +G++ V + L+  GA  D  +    TA  +A     D    +L
Sbjct: 200 GCKDRK-GYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIEL 258

Query: 274 VDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLA 333
           V+              +K    +  A    N  L  E+   + + VN  + +G +PL +A
Sbjct: 259 VN-----AGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMA 313

Query: 334 AVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNG 393
           A+ G+    Q+L++  +++D  D   G T L  A  +G++ ++  L+  GAD   R  + 
Sbjct: 314 AIHGRFTRSQILIQNGSEIDCADK-FGNTPLHVAARYGHELLISTLMTNGADTARRGIHD 372

Query: 394 YTAFDLVMLLNDPD 407
                L +L    D
Sbjct: 373 MFPLHLAVLFGFSD 386



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 88/352 (25%), Positives = 141/352 (40%), Gaps = 18/352 (5%)

Query: 65  VGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHV 124
           + A   ++  D  G T L  AA+GG+   +  LL  GA +  R+ +G + L  AA  G  
Sbjct: 410 LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSY 469

Query: 125 SVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQL---- 180
             A  L+  GA VN  +  G S L  A+        +    +    +   P  E      
Sbjct: 470 QCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEA 529

Query: 181 ----------GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGAD-PNHAARTVGWSPL 229
                     G   S  +    TA+  A  +G+   + LL+E   +       T+  SPL
Sbjct: 530 FFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPL 589

Query: 230 MLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDE 289
            LAA  G     + L E   N D      +TA  +A +    + V+ L          + 
Sbjct: 590 HLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKER 649

Query: 290 EKRRPDIFHALKMGNFQLVKEIAD--EDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVE 347
           +++   +  A   G+   +  + D  E     ++++  G TPLMLA + G +  V LL+E
Sbjct: 650 KRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLE 709

Query: 348 RHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDL 399
           + +  D  D + G TAL +    G ++ +  LL+  A V  R   G T   L
Sbjct: 710 KGSTADAAD-LRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL 760



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 67/234 (28%), Positives = 105/234 (44%), Gaps = 4/234 (1%)

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD 252
           T L AA   G   +++LL+  GA+ N A  T+  +PL  AA +    V   L+   A+ +
Sbjct: 43  TPLHAAAYVGDVPILQLLLMSGANVN-AKDTLWLTPLHRAAASRNEKVLGLLLAHSADVN 101

Query: 253 HLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIA 312
               L +T   VA   +     + L PL +     D   R   + HA+  G+ + V  + 
Sbjct: 102 ARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGRSA-LHHAVHSGHLETVNLLL 160

Query: 313 DEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGN 372
           ++  S +N+ +     PL  AA  G L +++LLV R AD+  +D   G+  L  A   G 
Sbjct: 161 NKGAS-LNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDR-KGYGLLHTAAASGQ 218

Query: 373 KEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLLASVCMQVNKDKG 426
            E+VKYLL  GA++      G TA  +   L      +  + A   +    DKG
Sbjct: 219 IEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKG 272



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 33/310 (10%)

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLL 131
           D  D  G T L  A   GH   V  LL +G++ ++ +  G +AL + A  G       LL
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741

Query: 132 DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLG-------- 183
           DH A V  ++  G + + +AS  GH  V++ LL+A    D      +  G          
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801

Query: 184 GSRD--------------EPLDITALMAAIQHGHEAVVRLLM-EWGADPNHAARTVGWSP 228
           G  D              E    T L  A+ +  ++   +L+   GA   ++    G +P
Sbjct: 802 GHEDCLELLLEHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861

Query: 229 LMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTD 288
           L  AA    +   + L++  A  +      +TA   A +      V++L      R K D
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFL----LYRGKAD 917

Query: 289 ----EEKRRPDIFHALKMGNFQLVKEIADE--DPSHVNLVNGDGATPLMLAAVTGQLALV 342
               +E +   +  A   G+ +    I  E  D   +N  N     PL +AA  G  ++V
Sbjct: 918 LTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVV 977

Query: 343 QLLVERHADV 352
           Q L+   A V
Sbjct: 978 QALLSHGATV 987



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 47/154 (30%), Positives = 73/154 (47%), Gaps = 13/154 (8%)

Query: 63  GAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFG 122
           GA+GA + V+  D  G T L  AA   +   +R LL+  A VN+ +H G +ALM AA  G
Sbjct: 844 GALGAKI-VNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENG 902

Query: 123 HVSVAHLLLDHG-ADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLG 181
             +    LL  G AD+   +    + L +A   GH     ++L             + LG
Sbjct: 903 QTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL----------AETQDLG 952

Query: 182 LGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGA 215
           L  + +  L +   +AA ++G  +VV+ L+  GA
Sbjct: 953 LINATNSALQMPLHIAA-RNGLASVVQALLSHGA 985


>gi|225543463 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 2 [Homo sapiens]
          Length = 1390

 Score =  101 bits (252), Expect = 3e-21
 Identities = 99/334 (29%), Positives = 150/334 (44%), Gaps = 40/334 (11%)

Query: 95   RFLLRRGASVNSRNHYGWSA--LMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVAS 152
            R L+  GA+VN R     +A  L   +  GH  V  LLL+ GA ++  +  G + L  A+
Sbjct: 909  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 968

Query: 153  RGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM- 211
              GH+ +V LL + G  VDH    G+               AL+ +   GH  +++ L+ 
Sbjct: 969  AAGHMKLVCLLTKKGVRVDHLDKKGQ--------------CALVHSALRGHGDILQYLLT 1014

Query: 212  -EWGADP--------NHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAF 262
             EW   P        +HA +      L  AA  G   V Q L+  G   +H   +  T  
Sbjct: 1015 CEWSPGPPQPGTLRKSHALQ----QALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDT 1068

Query: 263  ---EVALD-CKHRDLVDYLDPLTTVRPKTDEEKRR--PDIFHALKMGNFQLVKEIADEDP 316
               E AL     R  ++  + L           RR  P +F A + G++Q+V+ +  E  
Sbjct: 1069 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLL-ERG 1127

Query: 317  SHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
              VNL +  G TPLM+AA  G L+ V+ L+ + A +   D   G +AL  A   G++ +V
Sbjct: 1128 CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDK-EGLSALSWACLKGHRAVV 1186

Query: 377  KYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
            +YL+ +GA +    KNG T  DL     D +T L
Sbjct: 1187 QYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVL 1220



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 99/328 (30%), Positives = 137/328 (41%), Gaps = 63/328 (19%)

Query: 69   VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVN-------SRNHYGWSALMQAARF 121
            V VD  D+ G  AL  +A  GH  ++++LL    S          ++H    AL  AA  
Sbjct: 984  VRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASM 1043

Query: 122  GHVSVAHLLL----DHGADVNAQNRL-GASVLTVASRGGHLGVVKLLLEAGAFVDHHHPS 176
            GH SV   LL    +H  +VN  + L G + LT A+  G L V +LLL  GA V      
Sbjct: 1044 GHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAV------ 1097

Query: 177  GEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTG 236
                    SR     +  L  A + GH  +VRLL+E G D N + +  G +PLM+AA  G
Sbjct: 1098 --------SRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ-GRTPLMVAACEG 1148

Query: 237  RLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDI 296
             L   + L+ KGA    L     +A   A    HR +V YL                   
Sbjct: 1149 HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL------------------- 1189

Query: 297  FHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQD 356
                             E+ + ++  + +G TPL LAA  G    V  LVE+ A ++  D
Sbjct: 1190 ----------------VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD 1233

Query: 357  SVHGWTALMQATYHGNKEIVKYLLNQGA 384
               G   L +A    N  +V  LL +GA
Sbjct: 1234 H-SGMRPLDRAIGCRNTSVVVALLRKGA 1260



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 74/241 (30%), Positives = 98/241 (40%), Gaps = 17/241 (7%)

Query: 11   QLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAV--GAP 68
            Q L  A   G +   + LL        E         E A    AG G      +  G  
Sbjct: 1035 QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHG 1094

Query: 69   VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAH 128
              V  ++  G   L  AA  GH  +VR LL RG  VN  +  G + LM AA  GH+S   
Sbjct: 1095 AAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVE 1154

Query: 129  LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE 188
             LL  GA +++ ++ G S L+ A   GH  VV+ L+E GA +D    +G           
Sbjct: 1155 FLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR---------T 1205

Query: 189  PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKG 248
            PLD+ A      +G    V  L+E GA   H   + G  PL  A       V   L+ KG
Sbjct: 1206 PLDLAAF-----YGDAETVLYLVEKGAVIEHVDHS-GMRPLDRAIGCRNTSVVVALLRKG 1259

Query: 249  A 249
            A
Sbjct: 1260 A 1260



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 60/179 (33%), Positives = 90/179 (50%), Gaps = 21/179 (11%)

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            V+ SD+ G T L  AA  GH   V FLL +GA+++S +  G SAL  A   GH +V   L
Sbjct: 1130 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1189

Query: 131  LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
            ++ GA ++  ++ G + L +A+  G    V  L+E GA ++H   SG +         PL
Sbjct: 1190 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR---------PL 1240

Query: 191  DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWS-PLMLAALTGRLGVAQQLVEKG 248
            D      AI   + +VV  L+  GA   +AA  +  S P +L  L       Q+L+E+G
Sbjct: 1241 D-----RAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIIL------LQKLMEEG 1288


>gi|225543461 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 1 isoform 1 [Homo sapiens]
          Length = 1861

 Score =  101 bits (252), Expect = 3e-21
 Identities = 99/334 (29%), Positives = 150/334 (44%), Gaps = 40/334 (11%)

Query: 95   RFLLRRGASVNSRNHYGWSA--LMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVAS 152
            R L+  GA+VN R     +A  L   +  GH  V  LLL+ GA ++  +  G + L  A+
Sbjct: 917  RLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGTSENGMTALCYAA 976

Query: 153  RGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLM- 211
              GH+ +V LL + G  VDH    G+               AL+ +   GH  +++ L+ 
Sbjct: 977  AAGHMKLVCLLTKKGVRVDHLDKKGQ--------------CALVHSALRGHGDILQYLLT 1022

Query: 212  -EWGADP--------NHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAF 262
             EW   P        +HA +      L  AA  G   V Q L+  G   +H   +  T  
Sbjct: 1023 CEWSPGPPQPGTLRKSHALQ----QALTAAASMGHSSVVQCLL--GMEKEHEVEVNGTDT 1076

Query: 263  ---EVALD-CKHRDLVDYLDPLTTVRPKTDEEKRR--PDIFHALKMGNFQLVKEIADEDP 316
               E AL     R  ++  + L           RR  P +F A + G++Q+V+ +  E  
Sbjct: 1077 LWGETALTAAAGRGKLEVCELLLGHGAAVSRTNRRGVPPLFCAARQGHWQIVRLLL-ERG 1135

Query: 317  SHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
              VNL +  G TPLM+AA  G L+ V+ L+ + A +   D   G +AL  A   G++ +V
Sbjct: 1136 CDVNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDK-EGLSALSWACLKGHRAVV 1194

Query: 377  KYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTEL 410
            +YL+ +GA +    KNG T  DL     D +T L
Sbjct: 1195 QYLVEEGAAIDQTDKNGRTPLDLAAFYGDAETVL 1228



 Score = 90.9 bits (224), Expect = 5e-18
 Identities = 99/328 (30%), Positives = 137/328 (41%), Gaps = 63/328 (19%)

Query: 69   VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVN-------SRNHYGWSALMQAARF 121
            V VD  D+ G  AL  +A  GH  ++++LL    S          ++H    AL  AA  
Sbjct: 992  VRVDHLDKKGQCALVHSALRGHGDILQYLLTCEWSPGPPQPGTLRKSHALQQALTAAASM 1051

Query: 122  GHVSVAHLLL----DHGADVNAQNRL-GASVLTVASRGGHLGVVKLLLEAGAFVDHHHPS 176
            GH SV   LL    +H  +VN  + L G + LT A+  G L V +LLL  GA V      
Sbjct: 1052 GHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHGAAV------ 1105

Query: 177  GEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTG 236
                    SR     +  L  A + GH  +VRLL+E G D N + +  G +PLM+AA  G
Sbjct: 1106 --------SRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQ-GRTPLMVAACEG 1156

Query: 237  RLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDI 296
             L   + L+ KGA    L     +A   A    HR +V YL                   
Sbjct: 1157 HLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL------------------- 1197

Query: 297  FHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQD 356
                             E+ + ++  + +G TPL LAA  G    V  LVE+ A ++  D
Sbjct: 1198 ----------------VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD 1241

Query: 357  SVHGWTALMQATYHGNKEIVKYLLNQGA 384
               G   L +A    N  +V  LL +GA
Sbjct: 1242 H-SGMRPLDRAIGCRNTSVVVALLRKGA 1268



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 74/241 (30%), Positives = 98/241 (40%), Gaps = 17/241 (7%)

Query: 11   QLLLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAGAEVAGPGAAAAGAV--GAP 68
            Q L  A   G +   + LL        E         E A    AG G      +  G  
Sbjct: 1043 QALTAAASMGHSSVVQCLLGMEKEHEVEVNGTDTLWGETALTAAAGRGKLEVCELLLGHG 1102

Query: 69   VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAH 128
              V  ++  G   L  AA  GH  +VR LL RG  VN  +  G + LM AA  GH+S   
Sbjct: 1103 AAVSRTNRRGVPPLFCAARQGHWQIVRLLLERGCDVNLSDKQGRTPLMVAACEGHLSTVE 1162

Query: 129  LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE 188
             LL  GA +++ ++ G S L+ A   GH  VV+ L+E GA +D    +G           
Sbjct: 1163 FLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAAIDQTDKNGR---------T 1213

Query: 189  PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKG 248
            PLD+ A      +G    V  L+E GA   H   + G  PL  A       V   L+ KG
Sbjct: 1214 PLDLAAF-----YGDAETVLYLVEKGAVIEHVDHS-GMRPLDRAIGCRNTSVVVALLRKG 1267

Query: 249  A 249
            A
Sbjct: 1268 A 1268



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 60/179 (33%), Positives = 90/179 (50%), Gaps = 21/179 (11%)

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            V+ SD+ G T L  AA  GH   V FLL +GA+++S +  G SAL  A   GH +V   L
Sbjct: 1138 VNLSDKQGRTPLMVAACEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYL 1197

Query: 131  LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
            ++ GA ++  ++ G + L +A+  G    V  L+E GA ++H   SG +         PL
Sbjct: 1198 VEEGAAIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMR---------PL 1248

Query: 191  DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWS-PLMLAALTGRLGVAQQLVEKG 248
            D      AI   + +VV  L+  GA   +AA  +  S P +L  L       Q+L+E+G
Sbjct: 1249 D-----RAIGCRNTSVVVALLRKGAKLGNAAWAMATSKPDILIIL------LQKLMEEG 1296


>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
            containing 2 [Homo sapiens]
          Length = 1990

 Score =  101 bits (251), Expect = 3e-21
 Identities = 72/197 (36%), Positives = 97/197 (49%), Gaps = 15/197 (7%)

Query: 78   GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
            G TAL  AA  G   + R LL +GA+V   N  G   L    R GH  +  LLL HGADV
Sbjct: 1034 GETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGADV 1093

Query: 138  NAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
            N  ++ G + L +A+  GHLG V  LL  GA +      G              +TAL  
Sbjct: 1094 NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEG--------------LTALSW 1139

Query: 198  AIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVL 257
            A   GH +VVR L++ GA  +HA +  G +PL LAA  G   V Q LV+ GA  +H+   
Sbjct: 1140 ACLKGHLSVVRSLVDNGAATDHADKN-GRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYS 1198

Query: 258  EKTAFEVALDCKHRDLV 274
                 + A+ C++  +V
Sbjct: 1199 GMRPLDRAVGCRNTSVV 1215



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 90/335 (26%), Positives = 145/335 (43%), Gaps = 54/335 (16%)

Query: 89   GHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVL 148
            G+  +V  LL  GA+V++ +  G + L  AA  G++S+  LL    A V+  ++ G   L
Sbjct: 896  GYTEMVALLLEFGANVDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCAL 955

Query: 149  TVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVR 208
              A+  GHL VVK L++    +     +G+Q G+   +       AL+AA   G+  +V 
Sbjct: 956  VHAALRGHLEVVKFLIQCDWTM-----AGQQQGV--FKKSHAIQQALIAAASMGYTEIVS 1008

Query: 209  LLMEW---------GADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEK 259
             L++           A  N      G + L  AA  G+L V + L+E+GA          
Sbjct: 1009 YLLDLPEKDEEEVERAQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGA---------- 1058

Query: 260  TAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHV 319
                                    +P     +    +F  ++ G++Q+V ++     + V
Sbjct: 1059 ---------------------AVAQP---NRRGAVPLFSTVRQGHWQIV-DLLLTHGADV 1093

Query: 320  NLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYL 379
            N+ +  G TPLM+AA  G L  V  L+ + A +   D   G TAL  A   G+  +V+ L
Sbjct: 1094 NMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDK-EGLTALSWACLKGHLSVVRSL 1152

Query: 380  LNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
            ++ GA      KNG T  DL       D E+V+ L
Sbjct: 1153 VDNGAATDHADKNGRTPLDLAAFYG--DAEVVQFL 1185



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 93/326 (28%), Positives = 137/326 (42%), Gaps = 21/326 (6%)

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            VD S E+G T L +AAA G+  +V  L ++ A V+  +  G  AL+ AA  GH+ V   L
Sbjct: 911  VDASSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFL 970

Query: 131  LD-------HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLG 183
            +            V  ++      L  A+  G+  +V  LL+     D       Q+   
Sbjct: 971  IQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE-KDEEEVERAQI--- 1026

Query: 184  GSRDEPLDITALMAAIQHGHEAVVRLLMEWG---ADPNHAARTVGWSPLMLAALTGRLGV 240
             S D     TAL AA   G   V RLL+E G   A PN      G  PL      G   +
Sbjct: 1027 NSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRR----GAVPLFSTVRQGHWQI 1082

Query: 241  AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL 300
               L+  GA+ +      +T   +A    H   VD+L          D+E      +  L
Sbjct: 1083 VDLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACL 1142

Query: 301  KMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHG 360
            K G+  +V+ + D   +  +  + +G TPL LAA  G   +VQ LV+  A ++  D   G
Sbjct: 1143 K-GHLSVVRSLVDNGAA-TDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVD-YSG 1199

Query: 361  WTALMQATYHGNKEIVKYLLNQGADV 386
               L +A    N  +V  LL +GA +
Sbjct: 1200 MRPLDRAVGCRNTSVVVTLLKKGAKI 1225



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 59/167 (35%), Positives = 83/167 (49%), Gaps = 7/167 (4%)

Query: 13   LLRACDQGDTETARRLLEPGAA--EPAERGAEPEAGAEPAGAEVAGPGAAAAGAVGAPVP 70
            L  A  +G  E  R LLE GAA  +P  RGA P       G           GA      
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIVDLLLTHGA-----D 1092

Query: 71   VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
            V+ +D+ G T L  AA+ GH   V FLL +GAS+   +  G +AL  A   GH+SV   L
Sbjct: 1093 VNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSL 1152

Query: 131  LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSG 177
            +D+GA  +  ++ G + L +A+  G   VV+ L++ GA ++H   SG
Sbjct: 1153 VDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGAMIEHVDYSG 1199



 Score = 73.6 bits (179), Expect = 8e-13
 Identities = 87/301 (28%), Positives = 128/301 (42%), Gaps = 41/301 (13%)

Query: 123  HVSVAHLLLDHGADVNAQNRL--GASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQL 180
            ++ V+ LL+  GA++N +  +   A +L V S  G+  +V LLLE GA VD    SG   
Sbjct: 862  NIKVSRLLILGGANINYRTEVLNNAPILCVQSHLGYTEMVALLLEFGANVDASSESG--- 918

Query: 181  GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV 240
                       +T L  A   G+ ++V LL +  A  +H  +  G   L+ AAL G L V
Sbjct: 919  -----------LTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKN-GQCALVHAALRGHLEV 966

Query: 241  AQQLVEKGANP--DHLSVLEKT-----AFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRR 293
             + L++           V +K+     A   A    + ++V YL  L     K +EE  R
Sbjct: 967  VKFLIQCDWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPE---KDEEEVER 1023

Query: 294  PDIFH------------ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLAL 341
              I              A   G  ++ + + ++  + V   N  GA PL      G   +
Sbjct: 1024 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAA-VAQPNRRGAVPLFSTVRQGHWQI 1082

Query: 342  VQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVM 401
            V LL+   ADV+  D   G T LM A   G+   V +LL QGA + L  K G TA     
Sbjct: 1083 VDLLLTHGADVNMADK-QGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWAC 1141

Query: 402  L 402
            L
Sbjct: 1142 L 1142


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 104/342 (30%), Positives = 145/342 (42%), Gaps = 33/342 (9%)

Query: 56  GPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSAL 115
           GP       +     V+  D AG T L  A   GH PLVR LL+RGA V + +  G +AL
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 116 MQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHP 175
            +AA  GH  VA LLL  GA   A++  G + L  A+  GH  +   LLEA         
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP-------- 163

Query: 176 SGEQLGLGGSRDEPLDI---TALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLA 232
                G G +  E  D    TA   A   G  AV+ LL   GA  + A        L++A
Sbjct: 164 -----GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGA--------LLVA 210

Query: 233 ALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKR 292
           A  GR    + L+ +GA  D       TA  +A        ++ L       P   +   
Sbjct: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLG-HGADPGIRDRHG 269

Query: 293 RPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADV 352
           R  +  A   G+   V+ +  +  + V+  +  G TPL  A+  G + +   L++R A V
Sbjct: 270 RSALHRAAARGHLLAVQLLVTQG-AEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV 328

Query: 353 DKQDSVHGW---TALMQATYHGNKEIVKYLLNQGADVTLRAK 391
           D      GW   T L  A   G+   V  LL++GA  TLR +
Sbjct: 329 D----ATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 80/225 (35%), Positives = 97/225 (43%), Gaps = 41/225 (18%)

Query: 20  GDTETARRLLEPGAAEPAERGAEPEAG--------------------AEPAG-------A 52
           G T  A RLLE     PA   AE   G                    A  AG       A
Sbjct: 151 GHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVA 210

Query: 53  EVAGPGAAAAGAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGW 112
             AG GAA    +     VD  D AG TAL  AAA G    +  LL  GA    R+ +G 
Sbjct: 211 AAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGR 270

Query: 113 SALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDH 172
           SAL +AA  GH+    LL+  GA+V+A++ LG + L  ASR GH+ V   LL+ GA VD 
Sbjct: 271 SALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVD- 329

Query: 173 HHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADP 217
                     G  R  PL + A     + GH   V LL+  GA P
Sbjct: 330 --------ATGWLRKTPLHLAA-----ERGHGPTVGLLLSRGASP 361



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 94/311 (30%), Positives = 128/311 (41%), Gaps = 62/311 (19%)

Query: 89  GHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVL 148
           G   LV  LLR+GASV  R+H G + L  A   GH  +  LLL  GA V A +R G + L
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTAL 111

Query: 149 TVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVR 208
             A+  GH  V +LLL+ GA       +G              +T L  A   GH  +  
Sbjct: 112 HEAAWHGHSRVAELLLQRGASAAARSGTG--------------LTPLHWAAALGHTLLAA 157

Query: 209 LLMEWGADPNHAARTV----GWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEV 264
            L+E    P  AA       GW+    AA  GRL V + L   GA  D   ++   A   
Sbjct: 158 RLLE-APGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRG 216

Query: 265 ALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNG 324
           A                                 AL+   F L +       + V+  +G
Sbjct: 217 A---------------------------------ALR---FLLARG------ARVDARDG 234

Query: 325 DGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGA 384
            GAT L LAA  G+   +++L+   AD   +D  HG +AL +A   G+   V+ L+ QGA
Sbjct: 235 AGATALGLAAALGRSQDIEVLLGHGADPGIRDR-HGRSALHRAAARGHLLAVQLLVTQGA 293

Query: 385 DVTLRAKNGYT 395
           +V  R   G T
Sbjct: 294 EVDARDTLGLT 304



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 86/288 (29%), Positives = 121/288 (42%), Gaps = 58/288 (20%)

Query: 111 GWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFV 170
           GW  L+QA   G   +   LL  GA V  ++  G + L +A   GH  +V+LLL+ GA V
Sbjct: 41  GWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV 100

Query: 171 DHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAART-VGWSPL 229
                +G               TAL  A  HGH  V  LL++ GA    AAR+  G +PL
Sbjct: 101 GAVDRAGR--------------TALHEAAWHGHSRVAELLLQRGASA--AARSGTGLTPL 144

Query: 230 MLAALTGRLGVAQQLVEK-GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTD 288
             AA  G   +A +L+E  G  P         A E                         
Sbjct: 145 HWAAALGHTLLAARLLEAPGPGP--------AAAEA------------------------ 172

Query: 289 EEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVER 348
           E+ R     H    G    V E+     + +     DGA  L++AA  G+ A ++ L+ R
Sbjct: 173 EDARGWTAAHWAAAGGRLAVLELLAAGGAGL-----DGA--LLVAAAAGRGAALRFLLAR 225

Query: 349 HADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTA 396
            A VD +D   G TAL  A   G  + ++ LL  GAD  +R ++G +A
Sbjct: 226 GARVDARDGA-GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSA 272



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 66/249 (26%), Positives = 91/249 (36%), Gaps = 54/249 (21%)

Query: 155 GHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWG 214
           G  G+V  LL  GA V+    +G               T L  A+  GH  +VRLL++ G
Sbjct: 52  GPAGLVTQLLRQGASVEERDHAGR--------------TPLHLAVLRGHAPLVRLLLQRG 97

Query: 215 ADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLV 274
           A P  A    G + L  AA  G   VA+ L+++GA+    S    T    A    H  L 
Sbjct: 98  A-PVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLA 156

Query: 275 DYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAA 334
             L                                E     P+     +  G T    AA
Sbjct: 157 ARL-------------------------------LEAPGPGPAAAEAEDARGWTAAHWAA 185

Query: 335 VTGQLALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY 394
             G+LA+++LL    A +D         AL+ A   G    +++LL +GA V  R   G 
Sbjct: 186 AGGRLAVLELLAAGGAGLDG--------ALLVAAAAGRGAALRFLLARGARVDARDGAGA 237

Query: 395 TAFDLVMLL 403
           TA  L   L
Sbjct: 238 TALGLAAAL 246



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 24/57 (42%), Positives = 28/57 (49%), Gaps = 2/57 (3%)

Query: 358 VHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL 414
           V GW  L+QA + G   +V  LL QGA V  R   G T   L +L       LVRLL
Sbjct: 39  VQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRG--HAPLVRLL 93



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 33/105 (31%), Positives = 39/105 (37%), Gaps = 5/105 (4%)

Query: 13  LLRACDQGDTETARRLLEPGAAEPAERGAEPEAGAEPAG-AEVAGPGAAAAGAVGAPVPV 71
           L RA  +G     + L+  GA    E  A    G  P   A   G    A   +     V
Sbjct: 273 LHRAAARGHLLAVQLLVTQGA----EVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQV 328

Query: 72  DCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALM 116
           D +     T L  AA  GH P V  LL RGAS   R  +   A M
Sbjct: 329 DATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVAQM 373


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 95/357 (26%), Positives = 156/357 (43%), Gaps = 29/357 (8%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLL 130
           V+  D    T L  A A   E  V+ L++  A VN+R+    + L  AA    V  A ++
Sbjct: 42  VNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101

Query: 131 LDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPL 190
           +   + VN  +R G + L  A+  GH+ +V LLL  GA ++                +  
Sbjct: 102 IPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAF--------------DKK 147

Query: 191 DITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
           D  AL  A   GH  VV LL+  GA+     +  G++PL  AA  G++ V + L+  G  
Sbjct: 148 DRRALHWAAYMGHLDVVALLINHGAEVTCKDKK-GYTPLHAAASNGQINVVKHLLNLGVE 206

Query: 251 PDHLSVLEKTAFEVAL----DCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQ 306
            D ++V   TA  +A     D    +L+DY                   +  A    +  
Sbjct: 207 IDEINVYGNTALHIACYNGQDAVVNELIDY-----GANVNQPNNNGFTPLHFAAASTHGA 261

Query: 307 LVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQ 366
           L  E+   + + VN+ + DG +PL + AV G+    Q L++   ++D  D   G T L  
Sbjct: 262 LCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDK-DGNTPLHV 320

Query: 367 ATYHGNKEIVKYLLNQGADVTLRAKNG-YTAFDLVMLLNDPDTELVRLLASVCMQVN 422
           A  +G++ ++  L   GAD    AK G ++ F L +   +  ++  R L S   +++
Sbjct: 321 AARYGHELLINTLRTSGADT---AKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEID 374



 Score = 87.0 bits (214), Expect = 7e-17
 Identities = 108/420 (25%), Positives = 168/420 (40%), Gaps = 68/420 (16%)

Query: 69  VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA- 127
           V +D  +  GNTAL  A   G + +V  L+  GA+VN  N+ G++ L  AA   H ++  
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCL 264

Query: 128 HLLLDHGADVNAQNRLGAS---------------------------------VLTVASRG 154
            LL+++GADVN Q++ G S                                  L VA+R 
Sbjct: 265 ELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARY 324

Query: 155 GHLGVVKLLLEAG-----------------AFVDHHHPSGEQLGLGGSRDEP--LDITAL 195
           GH  ++  L  +G                 A   H     + L  G   D P     T L
Sbjct: 325 GHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCL 384

Query: 196 MAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLS 255
            AA   G+   ++LL   GAD  H     G +PL  AA        + LV  GAN +   
Sbjct: 385 HAAAAGGNVECIKLLQSSGAD-FHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD 443

Query: 256 VLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADED 315
              +TA        H      +D   T+     +     +    LK     L  E   ++
Sbjct: 444 DWGRTAL-------HYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQN 496

Query: 316 PSHVNLVNGDGATPLMLAAVTGQLALVQLLVER-HADVDKQDSVHGWTALMQATYHGNKE 374
            ++ ++ + +G   +  AA  G    ++LL+ER ++  ++ DS    + L  A Y+G+ +
Sbjct: 497 DANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQ 556

Query: 375 IVKYLLNQGADVTLRAKNGYTAFDLVMLLNDPDTELVRLL----ASVCMQVNKDKGRPSH 430
            ++ LL    D+ +R + G TA DL        TE V  L    AS+ ++ N  K  P H
Sbjct: 557 ALEVLLQSLVDLDIRDEKGRTALDLAAFKG--HTECVEALINPGASIFVKDNVTKRTPLH 614



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 99/412 (24%), Positives = 164/412 (39%), Gaps = 92/412 (22%)

Query: 71  VDCSDEAGNTALQFAAAGGHEPLV---------------------------------RFL 97
           +DC D+ GNT L  AA  GHE L+                                 R L
Sbjct: 307 IDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKL 366

Query: 98  LRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVLTVASRGGHL 157
           L  G  +++ + +G + L  AA  G+V    LL   GAD + +++ G + L  A+   H 
Sbjct: 367 LSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHF 426

Query: 158 GVVKLLLEAGAFVDH---------HHPSGEQLG-----LGGSRDEPLDITALMAAIQHGH 203
             ++ L+  GA V+          H+ +   +      LG + D   ++       +   
Sbjct: 427 HCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEA 486

Query: 204 EAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEK----------GANPDH 253
              +  L++  A+P+   +  G++ +  AA  G     + L+E+          GA    
Sbjct: 487 TLCLEFLLQNDANPSIRDKE-GYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSP 545

Query: 254 LSVLEKTAFEVALDCKHRDLVD--------------------------YLDPLTTVRPKT 287
           L +        AL+   + LVD                           ++P  ++  K 
Sbjct: 546 LHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKD 605

Query: 288 DEEKRRPDIFHALKMGN----FQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQ 343
           +  KR P   HA  +       +L+ EIAD +P  V++ +  G TPLMLA   G +  V 
Sbjct: 606 NVTKRTP--LHASVINGHTLCLRLLLEIAD-NPEAVDVKDAKGQTPLMLAVAYGHIDAVS 662

Query: 344 LLVERHADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYT 395
           LL+E+ A+VD  D + G TAL +    G++E V+ LL Q   +  +   G T
Sbjct: 663 LLLEKEANVDTVD-ILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRT 713



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 82/315 (26%), Positives = 128/315 (40%), Gaps = 56/315 (17%)

Query: 75  DEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGW--SALMQAARFGHVSVAHLLLD 132
           D+ G  ++ +AAA GH   +  LL R  S    +  G   S L  AA  GH     +LL 
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563

Query: 133 HGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDI 192
              D++ ++  G + L +A+  GH   V+ L+  GA +               +D     
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIF-------------VKDNVTKR 610

Query: 193 TALMAAIQHGHEAVVRLLMEWGADPN--HAARTVGWSPLMLAALTGRLGVAQQLVEKGAN 250
           T L A++ +GH   +RLL+E   +P         G +PLMLA   G +     L+EK AN
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 251 PDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKE 310
            D + +L  TA    +   H + V  L                             L +E
Sbjct: 671 VDTVDILGCTALHRGIMTGHEECVQML-----------------------------LEQE 701

Query: 311 IADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVER---HADVDKQDSVHGWTALMQA 367
           ++      +   +  G TPL  AA  G    +  L++      D   +D+  G+T L  A
Sbjct: 702 VS------ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDN-QGYTPLHWA 754

Query: 368 TYHGNKEIVKYLLNQ 382
            Y+GN+  ++ LL Q
Sbjct: 755 CYNGNENCIEVLLEQ 769



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 99/352 (28%), Positives = 146/352 (41%), Gaps = 51/352 (14%)

Query: 69  VPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARF-GHVSVA 127
           V +D  DE G TAL  AA  GH   V  L+  GAS+  +++      + A+   GH    
Sbjct: 566 VDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCL 625

Query: 128 HLLL---DHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGG 184
            LLL   D+   V+ ++  G + L +A   GH+  V LLLE  A VD             
Sbjct: 626 RLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD------------- 672

Query: 185 SRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQL 244
              + L  TAL   I  GHE  V++L+E          + G +PL  AA  G      +L
Sbjct: 673 -TVDILGCTALHRGIMTGHEECVQMLLEQEVS-ILCKDSRGRTPLHYAAARGHATWLSEL 730

Query: 245 VE-------------KGANPDHLSVL--EKTAFEVALDCK-HRDLVDYLDPLTTVRPKTD 288
           ++             +G  P H +     +   EV L+ K  R  +   +P T +     
Sbjct: 731 LQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIG--NPFTPLHCAII 788

Query: 289 EEKRRPDIFHALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVER 348
            +            GN   +  +   D S V+  +  G TPL  AA    +  +QLL+  
Sbjct: 789 NDH-----------GNCASLL-LGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRH 836

Query: 349 HADVDKQDSVHGWTALMQATYHGNKEIVKYLLNQG-ADVTLRAKNGYTAFDL 399
            A V+  D+  G TALM A  +G    V  L+N   AD+T++ K+  T   L
Sbjct: 837 SAPVNAVDN-SGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHL 887



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 71/268 (26%), Positives = 127/268 (47%), Gaps = 20/268 (7%)

Query: 129 LLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDE 188
           +L+    DVN  +    + L VA+  G   +++LL+ +GA V              +  +
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARV--------------NAKD 46

Query: 189 PLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGW-SPLMLAALTGRLGVAQQLVEK 247
            + +T L  A+    E  V++L++  AD N  AR   W +PL +AA    +  A+ ++  
Sbjct: 47  NMWLTPLHRAVASRSEEAVQVLIKHSADVN--ARDKNWQTPLHVAAANKAVKCAEVIIPL 104

Query: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQL 307
            ++ +      +TA   A    H ++V+ L          D++ RR  +  A  MG+  +
Sbjct: 105 LSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRA-LHWAAYMGHLDV 163

Query: 308 VKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQDSVHGWTALMQA 367
           V  + +   + V   +  G TPL  AA  GQ+ +V+ L+    ++D + +V+G TAL  A
Sbjct: 164 VALLINHG-AEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEID-EINVYGNTALHIA 221

Query: 368 TYHGNKEIVKYLLNQGADVTLRAKNGYT 395
            Y+G   +V  L++ GA+V     NG+T
Sbjct: 222 CYNGQDAVVNELIDYGANVNQPNNNGFT 249



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 81/302 (26%), Positives = 139/302 (46%), Gaps = 27/302 (8%)

Query: 97  LLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASVL--TVASRG 154
           L+ +   VN+ +    + L  AA  G   +  LL+  GA VNA++ +  + L   VASR 
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 155 GHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWG 214
                V++L++  A V+    + +          PL + A   A++   E ++ LL    
Sbjct: 62  EE--AVQVLIKHSADVNARDKNWQ---------TPLHVAAANKAVKCA-EVIIPLLSSVN 109

Query: 215 ADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLV 274
                     G + L  AAL G + +   L+ KGAN +     ++ A   A    H D+V
Sbjct: 110 VSDRG-----GRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVV 164

Query: 275 DYLDPLTTVRPKTDEEKRRPDIFH-ALKMGNFQLVKEIADEDPSHVNLVNGDGATPLMLA 333
             L  +      T ++K+     H A   G   +VK + +     ++ +N  G T L +A
Sbjct: 165 ALL--INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLG-VEIDEINVYGNTALHIA 221

Query: 334 AVTGQLALVQLLVERHADVDKQDSVHGWTAL--MQATYHGNKEIVKYLLNQGADVTLRAK 391
              GQ A+V  L++  A+V+ Q + +G+T L    A+ HG    ++ L+N GADV +++K
Sbjct: 222 CYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAAASTHG-ALCLELLVNNGADVNIQSK 279

Query: 392 NG 393
           +G
Sbjct: 280 DG 281



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 33/104 (31%), Positives = 55/104 (52%), Gaps = 2/104 (1%)

Query: 63  GAVGAPVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFG 122
           GA+ + + V C D+ G T L+ AA   H   ++ LLR  A VN+ ++ G +ALM AA  G
Sbjct: 800 GAIDSSI-VSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENG 858

Query: 123 HVSVAHLLLDHG-ADVNAQNRLGASVLTVASRGGHLGVVKLLLE 165
                 +L++   AD+  +++   + L +A   GH     L+L+
Sbjct: 859 QAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILD 902



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 73/322 (22%), Positives = 121/322 (37%), Gaps = 48/322 (14%)

Query: 68  PVPVDCSDEAGNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVA 127
           P  VD  D  G T L  A A GH   V  LL + A+V++ +  G +AL +    GH    
Sbjct: 635 PEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECV 694

Query: 128 HLLLDHGADVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRD 187
            +LL+    +  ++  G + L  A+  GH   +  LL+     +       Q        
Sbjct: 695 QMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQ-------- 746

Query: 188 EPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEK 247
                T L  A  +G+E  + +L+E             ++PL  A +      A  L   
Sbjct: 747 ---GYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP--FTPLHCAIINDHGNCASLL--- 798

Query: 248 GANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQL 307
                 L  ++ +     + C+                  D++ R P    A    +   
Sbjct: 799 ------LGAIDSS----IVSCR------------------DDKGRTP--LRAAAFADHVE 828

Query: 308 VKEIADEDPSHVNLVNGDGATPLMLAAVTGQLALVQLLV-ERHADVDKQDSVHGWTALMQ 366
             ++     + VN V+  G T LM+AA  GQ   V +LV    AD+  +D     T L  
Sbjct: 829 CLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLN-TPLHL 887

Query: 367 ATYHGNKEIVKYLLNQGADVTL 388
           A   G+++    +L++  D +L
Sbjct: 888 ACSKGHEKCALLILDKIQDESL 909


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 90/314 (28%), Positives = 141/314 (44%), Gaps = 32/314 (10%)

Query: 88  GGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASV 147
           GG +  +R L+ +G   +     G++AL  A    +  +   LL  GAD+      G + 
Sbjct: 78  GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTA 137

Query: 148 LTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVV 207
           L +A+  GHL    +LL+ GA V              +  + +  T L  A  +GHE V 
Sbjct: 138 LHIATIAGHLEAADVLLQHGANV--------------NIQDAVFFTPLHIAAYYGHEQVT 183

Query: 208 RLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA--------NPDHLSVLEK 259
           RLL+++GAD N  +  VG  PL LA+  G L +A+ L+E+G+        N DH+ +   
Sbjct: 184 RLLLKFGADVN-VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 242

Query: 260 TAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD-EDPS 317
           + F       H D+V Y L     V+P          +  A   G F++ KEI       
Sbjct: 243 SRF------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 296

Query: 318 HVNLVNGDGATPLMLAAVTGQ-LALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
            +   N    T    A   G+ + LV+ L++++          G T L  A YHG+  +V
Sbjct: 297 SLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLV 356

Query: 377 KYLLNQGADVTLRA 390
           ++LL+ GAD+ L A
Sbjct: 357 QFLLDNGADMNLVA 370



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 78/279 (27%), Positives = 119/279 (42%), Gaps = 48/279 (17%)

Query: 78  GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
           G TAL  A   GH      LL+ GA+VN ++   ++ L  AA +GH  V  LLL  GADV
Sbjct: 134 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV 193

Query: 138 NAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
           N    +G   L +AS  G L + KLL+E G+  D +    E            D   L  
Sbjct: 194 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE------------DHVPLHF 241

Query: 198 AIQHGHEAVVRLLMEWGADPN-HAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD--HL 254
             + GH  +V+ L++   +   H     G +PL LA   G+  VA+++++          
Sbjct: 242 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKE 301

Query: 255 SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADE 314
           ++  +TAF  A  C +   +D                               LVK + D+
Sbjct: 302 NIFSETAFHSA--CTYGKSID-------------------------------LVKFLLDQ 328

Query: 315 DPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
           +  ++N    DG T L  A   G + LVQ L++  AD++
Sbjct: 329 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 367



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 9/140 (6%)

Query: 78  GNTALQFAAAGGHEPLVRFLLRRGA--SVNSRNHYGWSALMQAARFGH-VSVAHLLLDHG 134
           G+T L  A   G   + + +++     S+   N +  +A   A  +G  + +   LLD  
Sbjct: 270 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 329

Query: 135 A-DVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193
             ++N Q R G + L  A   GH+ +V+ LL+ GA  D +  + +     G +DE    T
Sbjct: 330 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA--DMNLVACDPSRSSGEKDEQ---T 384

Query: 194 ALMAAIQHGHEAVVRLLMEW 213
            LM A + GH+A+V LL  +
Sbjct: 385 CLMWAYEKGHDAIVTLLKHY 404



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 54/221 (24%), Positives = 92/221 (41%), Gaps = 6/221 (2%)

Query: 181 GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV 240
           GL  SR      TAL  A+   +  ++  L+  GAD        G + L +A + G L  
Sbjct: 91  GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYG-GLTALHIATIAGHLEA 149

Query: 241 AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL 300
           A  L++ GAN +    +  T   +A    H  +   L         + E   RP +  A 
Sbjct: 150 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP-LHLAS 208

Query: 301 KMGNFQLVKEIADE-DPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQD-SV 358
             G   + K + +E   + VN  + +   PL   +  G   +V+ L++   +V     ++
Sbjct: 209 AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 268

Query: 359 HGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY--TAF 397
           +G T L  A Y+G  E+ K ++      +L  +N +  TAF
Sbjct: 269 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAF 309



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 16/44 (36%), Positives = 24/44 (54%)

Query: 359 HGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVML 402
           +G+TAL  A Y  N E++  LL+ GAD+      G TA  +  +
Sbjct: 100 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 143


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 90/314 (28%), Positives = 141/314 (44%), Gaps = 32/314 (10%)

Query: 88  GGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADVNAQNRLGASV 147
           GG +  +R L+ +G   +     G++AL  A    +  +   LL  GAD+      G + 
Sbjct: 179 GGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTA 238

Query: 148 LTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMAAIQHGHEAVV 207
           L +A+  GHL    +LL+ GA V              +  + +  T L  A  +GHE V 
Sbjct: 239 LHIATIAGHLEAADVLLQHGANV--------------NIQDAVFFTPLHIAAYYGHEQVT 284

Query: 208 RLLMEWGADPNHAARTVGWSPLMLAALTGRLGVAQQLVEKGA--------NPDHLSVLEK 259
           RLL+++GAD N  +  VG  PL LA+  G L +A+ L+E+G+        N DH+ +   
Sbjct: 285 RLLLKFGADVN-VSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFC 343

Query: 260 TAFEVALDCKHRDLVDY-LDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIAD-EDPS 317
           + F       H D+V Y L     V+P          +  A   G F++ KEI       
Sbjct: 344 SRF------GHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTE 397

Query: 318 HVNLVNGDGATPLMLAAVTGQ-LALVQLLVERHADVDKQDSVHGWTALMQATYHGNKEIV 376
            +   N    T    A   G+ + LV+ L++++          G T L  A YHG+  +V
Sbjct: 398 SLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYHGHIRLV 457

Query: 377 KYLLNQGADVTLRA 390
           ++LL+ GAD+ L A
Sbjct: 458 QFLLDNGADMNLVA 471



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 78/279 (27%), Positives = 119/279 (42%), Gaps = 48/279 (17%)

Query: 78  GNTALQFAAAGGHEPLVRFLLRRGASVNSRNHYGWSALMQAARFGHVSVAHLLLDHGADV 137
           G TAL  A   GH      LL+ GA+VN ++   ++ L  AA +GH  V  LLL  GADV
Sbjct: 235 GLTALHIATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADV 294

Query: 138 NAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDITALMA 197
           N    +G   L +AS  G L + KLL+E G+  D +    E            D   L  
Sbjct: 295 NVSGEVGDRPLHLASAKGFLNIAKLLMEEGSKADVNAQDNE------------DHVPLHF 342

Query: 198 AIQHGHEAVVRLLMEWGADPN-HAARTVGWSPLMLAALTGRLGVAQQLVEKGANPD--HL 254
             + GH  +V+ L++   +   H     G +PL LA   G+  VA+++++          
Sbjct: 343 CSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLTKE 402

Query: 255 SVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHALKMGNFQLVKEIADE 314
           ++  +TAF  A  C +   +D                               LVK + D+
Sbjct: 403 NIFSETAFHSA--CTYGKSID-------------------------------LVKFLLDQ 429

Query: 315 DPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVD 353
           +  ++N    DG T L  A   G + LVQ L++  AD++
Sbjct: 430 NVININHQGRDGHTGLHSACYHGHIRLVQFLLDNGADMN 468



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 40/140 (28%), Positives = 67/140 (47%), Gaps = 9/140 (6%)

Query: 78  GNTALQFAAAGGHEPLVRFLLRRGA--SVNSRNHYGWSALMQAARFGH-VSVAHLLLDHG 134
           G+T L  A   G   + + +++     S+   N +  +A   A  +G  + +   LLD  
Sbjct: 371 GDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQN 430

Query: 135 A-DVNAQNRLGASVLTVASRGGHLGVVKLLLEAGAFVDHHHPSGEQLGLGGSRDEPLDIT 193
             ++N Q R G + L  A   GH+ +V+ LL+ GA  D +  + +     G +DE    T
Sbjct: 431 VININHQGRDGHTGLHSACYHGHIRLVQFLLDNGA--DMNLVACDPSRSSGEKDEQ---T 485

Query: 194 ALMAAIQHGHEAVVRLLMEW 213
            LM A + GH+A+V LL  +
Sbjct: 486 CLMWAYEKGHDAIVTLLKHY 505



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 54/221 (24%), Positives = 92/221 (41%), Gaps = 6/221 (2%)

Query: 181 GLGGSRDEPLDITALMAAIQHGHEAVVRLLMEWGADPNHAARTVGWSPLMLAALTGRLGV 240
           GL  SR      TAL  A+   +  ++  L+  GAD        G + L +A + G L  
Sbjct: 192 GLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYG-GLTALHIATIAGHLEA 250

Query: 241 AQQLVEKGANPDHLSVLEKTAFEVALDCKHRDLVDYLDPLTTVRPKTDEEKRRPDIFHAL 300
           A  L++ GAN +    +  T   +A    H  +   L         + E   RP +  A 
Sbjct: 251 ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRP-LHLAS 309

Query: 301 KMGNFQLVKEIADE-DPSHVNLVNGDGATPLMLAAVTGQLALVQLLVERHADVDKQD-SV 358
             G   + K + +E   + VN  + +   PL   +  G   +V+ L++   +V     ++
Sbjct: 310 AKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNI 369

Query: 359 HGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGY--TAF 397
           +G T L  A Y+G  E+ K ++      +L  +N +  TAF
Sbjct: 370 YGDTPLHLACYNGKFEVAKEIIQISGTESLTKENIFSETAF 410



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 16/44 (36%), Positives = 24/44 (54%)

Query: 359 HGWTALMQATYHGNKEIVKYLLNQGADVTLRAKNGYTAFDLVML 402
           +G+TAL  A Y  N E++  LL+ GAD+      G TA  +  +
Sbjct: 201 NGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHIATI 244


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.130    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,531,512
Number of Sequences: 37866
Number of extensions: 2041221
Number of successful extensions: 22190
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 532
Number of HSP's successfully gapped in prelim test: 862
Number of HSP's that attempted gapping in prelim test: 11849
Number of HSP's gapped (non-prelim): 7153
length of query: 871
length of database: 18,247,518
effective HSP length: 111
effective length of query: 760
effective length of database: 14,044,392
effective search space: 10673737920
effective search space used: 10673737920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.