Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 67782319

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|67782319 spectrin beta isoform b [Homo sapiens]
         (2137 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|67782319 spectrin beta isoform b [Homo sapiens]                   4239   0.0  
gi|67782321 spectrin beta isoform a [Homo sapiens]                   4192   0.0  
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...  2648   0.0  
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...  2597   0.0  
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]         2303   0.0  
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...  1966   0.0  
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]        869   0.0  
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [...   577   e-164
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   574   e-163
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ...   568   e-161
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]           513   e-145
gi|12025678 actinin, alpha 4 [Homo sapiens]                           439   e-122
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]                431   e-120
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]                431   e-120
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]                  431   e-120
gi|4501893 actinin, alpha 2 [Homo sapiens]                            416   e-115
gi|4557241 actinin, alpha 3 [Homo sapiens]                            409   e-113
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        376   e-103
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        375   e-103
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        374   e-103
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        373   e-103
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       372   e-102
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       372   e-102
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        372   e-102
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        372   e-102
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   337   6e-92
gi|33188445 microfilament and actin filament cross-linker protei...   298   3e-80
gi|221316624 dystonin isoform 4 [Homo sapiens]                        298   4e-80
gi|221316622 dystonin isoform 3 [Homo sapiens]                        298   4e-80
gi|221316618 dystonin isoform 2 [Homo sapiens]                        298   4e-80

>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score = 4239 bits (10993), Expect = 0.0
 Identities = 2137/2137 (100%), Positives = 2137/2137 (100%)

Query: 1    MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60
            MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF
Sbjct: 1    MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60

Query: 61   TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120
            TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL
Sbjct: 61   TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120

Query: 121  QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180
            QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL
Sbjct: 121  QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180

Query: 181  LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240
            LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV
Sbjct: 181  LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240

Query: 241  AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300
            AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET
Sbjct: 241  AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300

Query: 301  EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360
            EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG
Sbjct: 301  EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360

Query: 361  NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420
            NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL
Sbjct: 361  NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420

Query: 421  EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480
            EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA
Sbjct: 421  EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480

Query: 481  LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
            LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS
Sbjct: 481  LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540

Query: 541  IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
            IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY
Sbjct: 541  IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600

Query: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
            QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY
Sbjct: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660

Query: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
            SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE
Sbjct: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720

Query: 721  VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
            VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA
Sbjct: 721  VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780

Query: 781  LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
            LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR
Sbjct: 781  LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840

Query: 841  QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
            QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL
Sbjct: 841  QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900

Query: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
            MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC
Sbjct: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960

Query: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
            VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ
Sbjct: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020

Query: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
            LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT
Sbjct: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
            QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140

Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
            QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200

Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
            EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260

Query: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
            EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA
Sbjct: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320

Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
            ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380

Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
            SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440

Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500
            QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500

Query: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
            AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG
Sbjct: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560

Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620
            HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620

Query: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
            VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE
Sbjct: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680

Query: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
            ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG
Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740

Query: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
            AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH
Sbjct: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800

Query: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
            RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT
Sbjct: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860

Query: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
            RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME
Sbjct: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920

Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980
            SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI
Sbjct: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980

Query: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040
            REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT
Sbjct: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040

Query: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100
            VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG
Sbjct: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100

Query: 2101 EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY 2137
            EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY
Sbjct: 2101 EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY 2137


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score = 4192 bits (10871), Expect = 0.0
 Identities = 2115/2115 (100%), Positives = 2115/2115 (100%)

Query: 1    MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60
            MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF
Sbjct: 1    MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60

Query: 61   TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120
            TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL
Sbjct: 61   TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120

Query: 121  QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180
            QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL
Sbjct: 121  QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180

Query: 181  LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240
            LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV
Sbjct: 181  LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240

Query: 241  AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300
            AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET
Sbjct: 241  AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300

Query: 301  EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360
            EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG
Sbjct: 301  EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360

Query: 361  NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420
            NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL
Sbjct: 361  NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420

Query: 421  EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480
            EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA
Sbjct: 421  EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480

Query: 481  LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
            LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS
Sbjct: 481  LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540

Query: 541  IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
            IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY
Sbjct: 541  IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600

Query: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
            QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY
Sbjct: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660

Query: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
            SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE
Sbjct: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720

Query: 721  VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
            VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA
Sbjct: 721  VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780

Query: 781  LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
            LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR
Sbjct: 781  LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840

Query: 841  QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
            QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL
Sbjct: 841  QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900

Query: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
            MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC
Sbjct: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960

Query: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
            VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ
Sbjct: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020

Query: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
            LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT
Sbjct: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
            QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140

Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
            QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200

Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
            EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260

Query: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
            EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA
Sbjct: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320

Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
            ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380

Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
            SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440

Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500
            QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500

Query: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
            AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG
Sbjct: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560

Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620
            HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620

Query: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
            VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE
Sbjct: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680

Query: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
            ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG
Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740

Query: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
            AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH
Sbjct: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800

Query: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
            RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT
Sbjct: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860

Query: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
            RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME
Sbjct: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920

Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980
            SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI
Sbjct: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980

Query: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040
            REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT
Sbjct: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040

Query: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100
            VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG
Sbjct: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100

Query: 2101 EAPVSHHAATERTSP 2115
            EAPVSHHAATERTSP
Sbjct: 2101 EAPVSHHAATERTSP 2115


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score = 2648 bits (6864), Expect = 0.0
 Identities = 1293/2110 (61%), Positives = 1655/2110 (78%), Gaps = 12/2110 (0%)

Query: 2    TSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFT 61
            T AT+++N+  Q  YS +N RWD   D+ DN+NSSARLFERSRIKALADERE VQKKTFT
Sbjct: 4    TVATDYDNIEIQQQYSDVNNRWDV--DDWDNENSSARLFERSRIKALADEREAVQKKTFT 61

Query: 62   KWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQ 121
            KWVNSHLARVSCRITDLY DLRDGRMLIKLLEVLSGE LPKPTKG+MRIHCLENVDKALQ
Sbjct: 62   KWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQ 121

Query: 122  FLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLL 181
            FLKEQRVHLENMGSHDIVDGNHRL LGLIWTIILRFQIQDI V+T++ +E +SAKDALLL
Sbjct: 122  FLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLL 181

Query: 182  WCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVA 241
            WCQMKTAGYP+VN+ NFT+SW+DG+AFNALIHKHRPDLIDFDKLK SNA +NL++AFN+A
Sbjct: 182  WCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLA 241

Query: 242  ERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETE 301
            E+ LG+  LLDPED+  ++PDEKSIITYVV +YHYFSKMK LAVEGKR+GKV+D+AIETE
Sbjct: 242  EQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETE 301

Query: 302  KMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGN 361
            KMIEKY  LASDLL WIEQTI +LN+RKFANSL GVQQQLQAF+TYRTVEKPPKF EKGN
Sbjct: 302  KMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361

Query: 362  LEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLE 421
            LEVLLFTIQS+MRANNQKVY P +GKL+SDIN+AWE LE+AE+ RELALRNELIRQEKLE
Sbjct: 362  LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421

Query: 422  QLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRAL 481
            QLARRFDRKAAMRETWLSENQRLV+QDNFG+DL AVEAA KKHEAIETD AAYEERV+A+
Sbjct: 422  QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAV 481

Query: 482  EDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI 541
              +A+ELE ENYHD KRITARKDN++RLW YL ELL++RRQRLE  L LQK+FQ+ML+ +
Sbjct: 482  VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIM 541

Query: 542  DWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGY 600
            DWMDE+K  +LS ++GKHLL VEDLLQKH L+EADI IQ ++V+ + A+  KF T+G+GY
Sbjct: 542  DWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGY 601

Query: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
            +PCDPQVI+DR++H+E C++EL  +AA R+A+LE+S+RLWKFFWEM E E WI+EKE+I 
Sbjct: 602  KPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKIL 661

Query: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
            SS DYGKDLTSV+ L  KH+AFEDE+ G   H EQ  +E   M+A + FG  +I  RI  
Sbjct: 662  SSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721

Query: 721  VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
            +  QW  L+ L+A  KK L++A    QFQ DADD+ AW+ D  +++S  DVG DE +T++
Sbjct: 722  IREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS 781

Query: 781  LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
            L KKHKD  EE+   R  ++ L +QA   P+E  +SPDV  RL  + E Y++V     LR
Sbjct: 782  LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLR 841

Query: 841  QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
            +Q LQ+ L LY +F E DACELW+ EKE+WL  M++P+ LEDLEV+QHRF+ L+ EM   
Sbjct: 842  KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQ 901

Query: 901  MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
             +++  VN  A  L+ SGHP  +E+K  QD LNTRW  F+ LV  +++A+ SAL + NY 
Sbjct: 902  ASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYH 961

Query: 961  VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
            ++C ET  WI +KTKV+EST+DLG DLAG++A+QRKL+G+ERD+ AI+A++  L++E+++
Sbjct: 962  LECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEK 1021

Query: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
            L   HP+Q + I  R   + ++W+ ++ +L+ +E  LGE S+LQ FL+DLDDFQ+WLS T
Sbjct: 1022 LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
            Q A+ASEDMP +L EAE+LL QH  IK+EID +++ YQ++++ GE V QGQTD +Y+ L 
Sbjct: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141

Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
            QRL+ LDTGWN L +MWE+R + L+Q   +Q+F +D KQAEA L+NQEY LAH E P +L
Sbjct: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201

Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
            E AEA I+K EDF+ +M+ N +K+ + V++G +LV++GN+ SD+I+EKV  I+DRHRKN 
Sbjct: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNR 1261

Query: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
            E A E  + L+DN +LQ FLQ+CQEL+LWIN+K+LT+QD+SYDEARNLH+KWLKHQAF+A
Sbjct: 1262 ETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMA 1321

Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
            ELAS++ WL+ I+ EG QL+ EKP+  A+V +KL  LH++W+ L++TT+ K Q L  A  
Sbjct: 1322 ELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK 1381

Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
            ++L  Q+ ADL+KW+  +E Q++SDD GKDLTSVN +L K + +E+Q+ VRK+E+ EL +
Sbjct: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQS 1441

Query: 1441 QVPSMGEEGGDAD------LSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWV 1494
            Q  ++ +EG   D      L+++ +F++LLEPL  RK  L +S+   Q +RD+EDE LWV
Sbjct: 1442 QAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501

Query: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLV-EAAEIDCQ 1553
             ER+PLA S D+G NLQTVQL +KKNQTLQ EI GH PR++D+ +R Q +V +++ +  +
Sbjct: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561

Query: 1554 DLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIP 1613
             + +RL  L+  W  L E    R +RL +A+ AQQYY DA EAEAW+ EQELY++S+E  
Sbjct: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621

Query: 1614 KDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYA 1673
            KDE+ A+ MLK+H   ++AVEDY   + QL+  ++ L++  HPE E+I   Q +VDK YA
Sbjct: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681

Query: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
            GLKD+AEER+ KL+  + LFQL RE DDLEQWI+E+E+VA S E+GQD++HVT+L+++FR
Sbjct: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR 1741

Query: 1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
            +FAR+TG IGQERVD VN   + LI++GHS+AATIAEWKDGLNE WADLLELIDTR Q+L
Sbjct: 1742 EFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQIL 1801

Query: 1794 AASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
            AASY+LH++++   EI G I +KH++LPE++G D +T E+  R+HT FE ++  LG QV+
Sbjct: 1802 AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1861

Query: 1854 QFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913
            Q Q+ A RLQ AYAG+KA+ IQ +E EV  AW++LLDAC  RR +LVDT DKFRFFSM R
Sbjct: 1862 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921

Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
            DL+ WME +IRQIE QE+PRDVSSVELLM  HQGI AEI+ R+ +F+ C+ELG+SLL R+
Sbjct: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981

Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLA 2033
            H ASEEI+EKL Q+  +RKEM +KWE RWE LR++LEV QFSRDASVAEAWL+ QEPYL+
Sbjct: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041

Query: 2034 SGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKE--RQIAERPAEETGP 2091
            S + G +VD VEKLIKRHEAFEKS A+W ERF+ALE+ TTLEL E  RQ  E   +   P
Sbjct: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPP 2101

Query: 2092 QEEEGETAGE 2101
              E      E
Sbjct: 2102 SPEPSTKVSE 2111



 Score =  259 bits (663), Expect = 2e-68
 Identities = 277/1456 (19%), Positives = 605/1456 (41%), Gaps = 79/1456 (5%)

Query: 298  IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
            +E   ++ ++   A D+  W+   + +++S    +           +ST   V+K     
Sbjct: 740  LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD---------EYSTQSLVKKHKDVA 790

Query: 358  EK-GNLEVLLFTIQSRMRANNQK-VYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
            E+  N    L T+  +  A  Q+   +P     +S I   ++ + E    R+ AL++ L 
Sbjct: 791  EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 850

Query: 416  RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
                   L + F    A  E W+ E ++ +        L  +E  + + E++E +     
Sbjct: 851  -------LYKMFSEADAC-ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA 902

Query: 476  ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
             RV  +  +A++L    +  +K I A++D +   WS  +EL+  ++  L + L++Q    
Sbjct: 903  SRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHL 962

Query: 536  DMLHSIDWMDE-IKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
            +   +  W+ E  K    + + G  L  V  L +K   ME D+     K+  +     K 
Sbjct: 963  ECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1022

Query: 595  TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIK 654
               +   P   Q I  R++ +   +EE+      R+A L ++ +L +F  ++D+ +SW+ 
Sbjct: 1023 ---ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1079

Query: 655  EKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFG--HP 712
              +   +S D    LT    L  +H+  ++E+   +   +++ ++   MV + Q    + 
Sbjct: 1080 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYM 1138

Query: 713  QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
             +  R++ +   W++L  +    +  L  +  + QF  D    +A+L +   +L+  ++ 
Sbjct: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198

Query: 773  QD-EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELY 830
               EGA  A+ KK +DF+  ++ +   +  + +  +    +   + D +  ++ ++ + +
Sbjct: 1199 TTLEGAEAAI-KKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRH 1257

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
            ++    A     RL++  DL     +     LW+ EK     +M   D   +L     + 
Sbjct: 1258 RKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEARNLHSKWLKH 1316

Query: 891  DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
                 E+ +    +D +      L+         VK+    L+  W+  ++    + + +
Sbjct: 1317 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1376

Query: 951  DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
              A +   +   C +  KW+      ++S  D G+DL  +  + +K   LE  +   +  
Sbjct: 1377 FDANKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNILLKKQQMLENQMEVRKKE 1435

Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
            ++ L+ ++Q L     +  +++  ++  ++  +  L + L  ++  L    ++  F +D+
Sbjct: 1436 IEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV 1494

Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
            +D   W+        S D   +L   + L++++  ++ EI GHQ     + E  + ++  
Sbjct: 1495 EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTD 1554

Query: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYT 1190
             +      + QRL  L   W  L    E R   L +    Q++  DA +AEA +S QE  
Sbjct: 1555 SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELY 1614

Query: 1191 LAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
            +   E     ++A + ++K +    ++E+  + V     +   LVA+ +  S++I  +  
Sbjct: 1615 MMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQS 1674

Query: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQD----VSYDEAR 1306
             ++  +    + A+E    L +   L    +   +L  WI ++ + +        Y+   
Sbjct: 1675 KVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVT 1734

Query: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
             L  ++ +       +      ++ ++    +L++      A +++  + L+  W +L  
Sbjct: 1735 MLQERFREFARDTGNIGQER--VDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1792

Query: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRS--DDPGKDLTSVNRMLAKLKRV 1424
                +TQ L+A  S +L    H D  +    ++D+ +   ++ G+D  +V  +       
Sbjct: 1793 LIDTRTQILAA--SYELHKFYH-DAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1849

Query: 1425 EDQVNVRKEELGELFAQVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQI 1483
            E  +     ++ +L      +     GD    I+KR  ++LE         ES R +L  
Sbjct: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909

Query: 1484 SRD-------LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
            + D       + D  LW+E+ +   ++ +   ++ +V+L M  +Q ++ EI         
Sbjct: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969

Query: 1537 VLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEA 1596
             ++ G+ L+       ++++E+L  L      + +    R + LR   E  Q+  DA  A
Sbjct: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029

Query: 1597 EAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHP 1656
            EAW+  QE Y+ S EI +  +    ++KRH   +++   +      L  R   L      
Sbjct: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL------ 2082

Query: 1657 EGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQW-------ISEK 1709
               +++ ++ Q ++         EERKR+  +     ++  E +  +QW       +S+ 
Sbjct: 2083 ---ELLEVRRQQEE---------EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQN 2130

Query: 1710 ELVA--SSPEMGQDFD 1723
             L A   SP M +  D
Sbjct: 2131 GLPAEQGSPRMAETVD 2146


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score = 2597 bits (6732), Expect = 0.0
 Identities = 1266/2068 (61%), Positives = 1621/2068 (78%), Gaps = 10/2068 (0%)

Query: 44   RIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKP 103
            R K L DERE VQKKTFTKWVNSHLARVSCRITDLY DLRDGRMLIKLLEVLSGE LPKP
Sbjct: 31   RFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90

Query: 104  TKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIV 163
            TKG+MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRL LGLIWTIILRFQIQDI 
Sbjct: 91   TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS 150

Query: 164  VQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFD 223
            V+T++ +E +SAKDALLLWCQMKTAGYP+VN+ NFT+SW+DG+AFNALIHKHRPDLIDFD
Sbjct: 151  VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD 210

Query: 224  KLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVL 283
            KLK SNA +NL++AFN+AE+ LG+  LLDPED+  ++PDEKSIITYVV +YHYFSKMK L
Sbjct: 211  KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL 270

Query: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
            AVEGKR+GKV+D+AIETEKMIEKY  LASDLL WIEQTI +LN+RKFANSL GVQQQLQA
Sbjct: 271  AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA 330

Query: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
            F+TYRTVEKPPKF EKGNLEVLLFTIQS+MRANNQKVY P +GKL+SDIN+AWE LE+AE
Sbjct: 331  FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE 390

Query: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKK 463
            + RELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV+QDNFG+DL AVEAA KK
Sbjct: 391  HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK 450

Query: 464  HEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQR 523
            HEAIETD AAYEERV+A+  +A+ELE ENYHD KRITARKDN++RLW YL ELL++RRQR
Sbjct: 451  HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR 510

Query: 524  LETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDK 583
            LE  L LQK+FQ+ML+ +DWMDE+K  +LS ++GKHLL VEDLLQKH L+EADI IQ ++
Sbjct: 511  LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER 570

Query: 584  VKAITAATLKF-TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKF 642
            V+ + A+  KF T+G+GY+PCDPQVI+DR++H+E C++EL  +AA R+A+LE+S+RLWKF
Sbjct: 571  VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF 630

Query: 643  FWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHG 702
            FWEM E E WI+EKE+I SS DYGKDLTSV+ L  KH+AFEDE+ G   H EQ  +E   
Sbjct: 631  FWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 690

Query: 703  MVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDA 762
            M+A + FG  +I  RI  +  QW  L+ L+A  KK L++A    QFQ DADD+ AW+ D 
Sbjct: 691  MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDI 750

Query: 763  HRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHR 822
             +++S  DVG DE +T++L KKHKD  EE+   R  ++ L +QA   P+E  +SPDV  R
Sbjct: 751  LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR 810

Query: 823  LQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLED 882
            L  + E Y++V     LR+Q LQ+ L LY +F E DACELW+ EKE+WL  M++P+ LED
Sbjct: 811  LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 870

Query: 883  LEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942
            LEV+QHRF+ L+ EM    +++  VN  A  L+ SGHP  +E+K  QD LNTRW  F+ L
Sbjct: 871  LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 930

Query: 943  VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLER 1002
            V  +++A+ SAL + NY ++C ET  WI +KTKV+EST+DLG DLAG++A+QRKL+G+ER
Sbjct: 931  VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 990

Query: 1003 DVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ 1062
            D+ AI+A++  L++E+++L   HP+Q + I  R   + ++W+ ++ +L+ +E  LGE S+
Sbjct: 991  DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1050

Query: 1063 LQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKE 1122
            LQ FL+DLDDFQ+WLS TQ A+ASEDMP +L EAE+LL QH  IK+EID +++ YQ++++
Sbjct: 1051 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1110

Query: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
             GE V QGQTD +Y+ L QRL+ LDTGWN L +MWE+R + L+Q   +Q+F +D KQAEA
Sbjct: 1111 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1170

Query: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
             L+NQEY LAH E P +LE AEA I+K EDF+ +M+ N +K+ + V++G +LV++GN+ S
Sbjct: 1171 FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1230

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSY 1302
            D+I+EKV  I+DRHRKN E A E  + L+DN +LQ FLQ+CQEL+LWIN+K+LT+QD+SY
Sbjct: 1231 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY 1290

Query: 1303 DEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWD 1362
            DEARNLH+KWLKHQAF+AELAS++ WL+ I+ EG QL+ EKP+  A+V +KL  LH++W+
Sbjct: 1291 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE 1350

Query: 1363 ELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLK 1422
             L++TT+ K Q L  A  ++L  Q+ ADL+KW+  +E Q++SDD GKDLTSVN +L K +
Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410

Query: 1423 RVEDQVNVRKEELGELFAQVPSMGEEGGDAD------LSIEKRFLDLLEPLGRRKKQLES 1476
             +E+Q+ VRK+E+ EL +Q  ++ +EG   D      L+++ +F++LLEPL  RK  L +
Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1470

Query: 1477 SRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
            S+   Q +RD+EDE LWV ER+PLA S D+G NLQTVQL +KKNQTLQ EI GH PR++D
Sbjct: 1471 SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1530

Query: 1537 VLQRGQQLV-EAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
            + +R Q +V +++ +  + + +RL  L+  W  L E    R +RL +A+ AQQYY DA E
Sbjct: 1531 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1590

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
            AEAW+ EQELY++S+E  KDE+ A+ MLK+H   ++AVEDY   + QL+  ++ L++  H
Sbjct: 1591 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSH 1650

Query: 1656 PEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASS 1715
            PE E+I   Q +VDK YAGLKD+AEER+ KL+  + LFQL RE DDLEQWI+E+E+VA S
Sbjct: 1651 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1710

Query: 1716 PEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775
             E+GQD++HVT+L+++FR+FAR+TG IGQERVD VN   + LI++GHS+AATIAEWKDGL
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770

Query: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835
            NE WADLLELIDTR Q+LAASY+LH++++   EI G I +KH++LPE++G D +T E+  
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1830

Query: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
            R+HT FE ++  LG QV+Q Q+ A RLQ AYAG+KA+ IQ +E EV  AW++LLDAC  R
Sbjct: 1831 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1890

Query: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
            R +LVDT DKFRFFSM RDL+ WME +IRQIE QE+PRDVSSVELLM  HQGI AEI+ R
Sbjct: 1891 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1950

Query: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
            + +F+ C+ELG+SLL R+H ASEEI+EKL Q+  +RKEM +KWE RWE LR++LEV QFS
Sbjct: 1951 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2010

Query: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLE 2075
            RDASVAEAWL+ QEPYL+S + G +VD VEKLIKRHEAFEKS A+W ERF+ALE+ TTLE
Sbjct: 2011 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070

Query: 2076 LKE--RQIAERPAEETGPQEEEGETAGE 2101
            L E  RQ  E   +   P  E      E
Sbjct: 2071 LLEVRRQQEEEERKRRPPSPEPSTKVSE 2098



 Score =  259 bits (662), Expect = 2e-68
 Identities = 271/1433 (18%), Positives = 597/1433 (41%), Gaps = 70/1433 (4%)

Query: 298  IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
            +E   ++ ++   A D+  W+   + +++S    +           +ST   V+K     
Sbjct: 727  LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD---------EYSTQSLVKKHKDVA 777

Query: 358  EK-GNLEVLLFTIQSRMRANNQK-VYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
            E+  N    L T+  +  A  Q+   +P     +S I   ++ + E    R+ AL++ L 
Sbjct: 778  EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 837

Query: 416  RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
                   L + F    A  E W+ E ++ +        L  +E  + + E++E +     
Sbjct: 838  -------LYKMFSEADAC-ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA 889

Query: 476  ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
             RV  +  +A++L    +  +K I A++D +   WS  +EL+  ++  L + L++Q    
Sbjct: 890  SRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHL 949

Query: 536  DMLHSIDWMDE-IKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
            +   +  W+ E  K    + + G  L  V  L +K   ME D+     K+  +     K 
Sbjct: 950  ECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1009

Query: 595  TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIK 654
               +   P   Q I  R++ +   +EE+      R+A L ++ +L +F  ++D+ +SW+ 
Sbjct: 1010 ---ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1066

Query: 655  EKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFG--HP 712
              +   +S D    LT    L  +H+  ++E+   +   +++ ++   MV + Q    + 
Sbjct: 1067 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYM 1125

Query: 713  QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
             +  R++ +   W++L  +    +  L  +  + QF  D    +A+L +   +L+  ++ 
Sbjct: 1126 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1185

Query: 773  QD-EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELY 830
               EGA  A+ KK +DF+  ++ +   +  + +  +    +   + D +  ++ ++ + +
Sbjct: 1186 TTLEGAEAAI-KKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRH 1244

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
            ++    A     RL++  DL     +     LW+ EK     +M   D   +L     + 
Sbjct: 1245 RKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEARNLHSKWLKH 1303

Query: 891  DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
                 E+ +    +D +      L+         VK+    L+  W+  ++    + + +
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1363

Query: 951  DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
              A +   +   C +  KW+      ++S  D G+DL  +  + +K   LE  +   +  
Sbjct: 1364 FDANKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNILLKKQQMLENQMEVRKKE 1422

Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
            ++ L+ ++Q L     +  +++  ++  ++  +  L + L  ++  L    ++  F +D+
Sbjct: 1423 IEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV 1481

Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
            +D   W+        S D   +L   + L++++  ++ EI GHQ     + E  + ++  
Sbjct: 1482 EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTD 1541

Query: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYT 1190
             +      + QRL  L   W  L    E R   L +    Q++  DA +AEA +S QE  
Sbjct: 1542 SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELY 1601

Query: 1191 LAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
            +   E     ++A + ++K +    ++E+  + V     +   LVA+ +  S++I  +  
Sbjct: 1602 MMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQS 1661

Query: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQD----VSYDEAR 1306
             ++  +    + A+E    L +   L    +   +L  WI ++ + +        Y+   
Sbjct: 1662 KVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVT 1721

Query: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
             L  ++ +       +      ++ ++    +L++      A +++  + L+  W +L  
Sbjct: 1722 MLQERFREFARDTGNIGQER--VDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1779

Query: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRS--DDPGKDLTSVNRMLAKLKRV 1424
                +TQ L+A  S +L    H D  +    ++D+ +   ++ G+D  +V  +       
Sbjct: 1780 LIDTRTQILAA--SYELHKFYH-DAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1836

Query: 1425 EDQVNVRKEELGELFAQVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQI 1483
            E  +     ++ +L      +     GD    I+KR  ++LE         ES R +L  
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1896

Query: 1484 SRD-------LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
            + D       + D  LW+E+ +   ++ +   ++ +V+L M  +Q ++ EI         
Sbjct: 1897 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1956

Query: 1537 VLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEA 1596
             ++ G+ L+       ++++E+L  L      + +    R + LR   E  Q+  DA  A
Sbjct: 1957 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2016

Query: 1597 EAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHP 1656
            EAW+  QE Y+ S EI +  +    ++KRH   +++   +      L  R   L      
Sbjct: 2017 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL------ 2069

Query: 1657 EGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEK 1709
               +++ ++ Q ++         EERKR+  +     ++  E +  +QW + K
Sbjct: 2070 ---ELLEVRRQQEE---------EERKRRPPSPEPSTKVSEEAESQQQWDTSK 2110


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score = 2303 bits (5969), Expect = 0.0
 Identities = 1154/2139 (53%), Positives = 1535/2139 (71%), Gaps = 22/2139 (1%)

Query: 3    SATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFTK 62
            S T+F+++  Q  YS IN RWD PD + DND+SSARLFERSRIKALADERE VQKKTFTK
Sbjct: 6    SPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTK 65

Query: 63   WVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQF 122
            WVNSHLARV+CR+ DLY DLRDGR L++LLEVLSGE+LPKPTKG+MRIHCLENVDKALQF
Sbjct: 66   WVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQF 125

Query: 123  LKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLW 182
            LKEQ+VHLENMGSHDIVDGNHRL LGL+WTIILRFQIQDI V+T++ +E +SAKDALLLW
Sbjct: 126  LKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLW 185

Query: 183  CQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAE 242
            CQMKTAGYP+VNV NFT+SW+DGLAFNA++HKHRPDL+DF+ LK  NA +NL++AFN+AE
Sbjct: 186  CQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAE 245

Query: 243  RQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEK 302
            ++LG+  LLDPEDV  + PDEKSIITYV  +YHYFSKMK LAVEGKR+GKV+DHA+E E+
Sbjct: 246  KELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAER 305

Query: 303  MIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNL 362
            ++EKY  LAS+LL WIEQTI  LN R+ ANSL+GVQ QLQ+F++YRTVEKPPKF EKGNL
Sbjct: 306  LVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNL 365

Query: 363  EVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQ 422
            EVLLFTIQS++RANNQKVYTP +G+L+SDIN+AWE LE+AE+ RELALR ELIRQEKLEQ
Sbjct: 366  EVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQ 425

Query: 423  LARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
            LA RFDRKAAMRETWLSENQRLV+QDNFG +LAAVEAA +KHEAIETD  AY  RV+A++
Sbjct: 426  LAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485

Query: 483  DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
             +A EL  E YHD KRI AR+ N+ RLW +L++++ +RR+RL   L LQK+FQD+L+ +D
Sbjct: 486  AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545

Query: 543  WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGYQ 601
            WM+E+K  L S + G+HL  VEDLLQ H+L+EADIA+Q ++V+A++A+ L+F   GK Y+
Sbjct: 546  WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605

Query: 602  PCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
            PCDPQ++ +R++ LEQ +E L  +AA R+A+LE+S+RLW+F WE+ EAE+W++E++ + +
Sbjct: 606  PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665

Query: 662  SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
            S D G+DLT  L L  KH A   E+ G    L+   ++   +VA    G  Q  AR  E+
Sbjct: 666  SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL 725

Query: 722  SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
             AQW++L+ LA    + L  A + +QFQ DA+D++AWL DA RL+S  ++G DE +T+AL
Sbjct: 726  QAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL 785

Query: 782  GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
             ++H+   EE+   R  ++ L +QA   P     +P+V  R+  L   Y+++ A+A  R 
Sbjct: 786  ARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERA 845

Query: 842  QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
            + L+ AL LYT+  E  AC LW+ EKE+WL  + +P+ LEDLEVVQ RF+ L+ EM TL 
Sbjct: 846  RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLA 905

Query: 902  TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
             QI  VN  A  L+++  P    +   Q+ LN RWQ F+ L   ++ A+ SAL + NY +
Sbjct: 906  AQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHL 965

Query: 962  DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
            +C ET  W+ +KTKV+EST+ LG DLAG++A+QRKL+G ERD+ AI ARV  L RE+  L
Sbjct: 966  ECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL 1025

Query: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
               HP Q   I  R + ++  W+ L+ +++ +E+ LGE  +LQ FL+ LDDFQAWL  TQ
Sbjct: 1026 AAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1085

Query: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQ 1141
             AVASE+ P +LPEAE LL QHA ++ E++  Q  Y R++  GE+V + Q DP+ L L Q
Sbjct: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145

Query: 1142 RLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLE 1201
            RLE L TGW  LGRMWESR   LAQ  GFQ F +DA+QAE +LS+QEY L+H E P +L+
Sbjct: 1146 RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQ 1205

Query: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNE 1261
            AA+A I+K EDF+ +M+ N +++   +++G +LV+EGN+++DKI+EK   IE RH+KN +
Sbjct: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQD 1265

Query: 1262 KAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAE 1321
             AQ+    LRDN E Q+FLQ+C EL LWI++K+LT+QDVSYDEARNLH KW KHQAF+AE
Sbjct: 1266 AAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAE 1325

Query: 1322 LASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
            LA+++ WL+ +D EG++L  EKP+  ALVS+KL  LHR WDEL+ TT+ K + L  A  +
Sbjct: 1326 LAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRA 1385

Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
            +L  Q+   L  W+ +++ QL SDD GKDLTSVN +L K + +E ++ VR++E+  + AQ
Sbjct: 1386 ELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQ 1445

Query: 1442 VPSMGEEGGDA------DLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
              ++ +E   A        ++E++F  L +P+  R ++L++SR + Q  RD+EDE LWV 
Sbjct: 1446 AKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVT 1505

Query: 1496 ERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDL 1555
            ERLP+A S ++G +L +VQL MKKNQTLQ EI GH PR+ D+ +R + L  AA       
Sbjct: 1506 ERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA------A 1559

Query: 1556 EERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKD 1615
               L  LQ  W RL      R +RL DA  AQQ+Y DA EAEAW+GEQEL+++  E  KD
Sbjct: 1560 GPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
            E  A   +K+H   ++A+ DY + I QLA+ +Q ++   HPE  +I   Q QVDK YAGL
Sbjct: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGL 1679

Query: 1676 KDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDF 1735
            K++A ER+ +L+    L QL+RE DDLEQWI E+E+VA+S E+GQD++HVT+LRDKFR+F
Sbjct: 1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREF 1739

Query: 1736 ARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAA 1795
            +R+T  IGQERVD+ NA    LI  GH+  AT+AEWKD LNE WADLLEL+DTR Q+LAA
Sbjct: 1740 SRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799

Query: 1796 SYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQF 1855
            +Y+L R+ +   + L  +  K ++LP+  G D + AE+  R H A+E ++  L  QVQQ 
Sbjct: 1800 AYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQV 1859

Query: 1856 QDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDL 1915
            QD   RLQ AYAG+KAE I    Q V+ AW  L  + A RR  L+DT DKFRFF   R+L
Sbjct: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVREL 1919

Query: 1916 LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQ 1975
            + WM+ +  Q++ QERPRDVSS +L++K  QGI AEIE R+  FS+C+++G+ LL R H 
Sbjct: 1920 MLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHY 1979

Query: 1976 ASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASG 2035
            A+EEI EKL Q+ +RR+E  EKW+ + + L+++LEV  F RDA +AEAWL +QEP + S 
Sbjct: 1980 AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSA 2039

Query: 2036 DFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQ-IAERPAEETGPQEE 2094
            + G TVD VE LIKRHEAF+KS  +W ERF ALEK T LE +E++   +R  EE   Q  
Sbjct: 2040 ELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPP 2099

Query: 2095 EGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEP 2133
              E     P       +  S         ++W+  QP P
Sbjct: 2100 APEPTASVPPGDLVGGQTAS--------DTTWDGTQPRP 2130


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
            sapiens]
          Length = 2564

 Score = 1966 bits (5092), Expect = 0.0
 Identities = 1029/2124 (48%), Positives = 1421/2124 (66%), Gaps = 50/2124 (2%)

Query: 6    EFENVGNQP-PYSRINARWDAPDDELDNDN-----SSARLFERSRIKALADEREVVQKKT 59
            E +N+   P P +   ARW++PD   + +      ++A LFE SRIKALADERE VQKKT
Sbjct: 7    EVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQKKT 66

Query: 60   FTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKA 119
            FTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE LP+PT+G+MRIH LENVDKA
Sbjct: 67   FTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKA 126

Query: 120  LQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDAL 179
            LQFLKEQRVHLEN+GSHDIVDGNHRL LGL+WTIILRFQIQ I ++T++ RETRSAKDAL
Sbjct: 127  LQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDAL 186

Query: 180  LLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFN 239
            LLWCQMKTAGYP VN+ NFT+SW+DGLAFNALIH+HRPDL+DF KL  SNA +NL+ AF 
Sbjct: 187  LLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFR 246

Query: 240  VAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIE 299
             AE+ LG+  LLDPEDV  E PDEKSIITYVV+FYHYFSKMK LAVEGKR+GKV+D  +E
Sbjct: 247  TAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLE 306

Query: 300  TEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEK 359
              K+IE+Y  LA++LL WI +T+ +++++KFANSL+GVQQQLQAF+ Y T+EKP KFQEK
Sbjct: 307  VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEK 366

Query: 360  GNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEK 419
            GNLEVLLF+IQS++RA N++++ P +G  + DI++AW  LE+AE+ RE ALR ELIRQEK
Sbjct: 367  GNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEK 426

Query: 420  LEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVR 479
            LE LA+RFD K AMRE+WL+ENQRLV+QDNFGY+L AVEAA KKHEAIE D AAYEERV+
Sbjct: 427  LELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQ 486

Query: 480  ALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH 539
             + +LAQ L  E Y+D +R+ A++D++LR W+ L  L+ +RR RLE  LALQK+FQ+M++
Sbjct: 487  GVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVY 546

Query: 540  SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKG 599
             +DWM+E++A LLS E G+HL+E +DLLQKH L+E DIA Q ++V+A+ AA L+F++ +G
Sbjct: 547  MVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQG 606

Query: 600  YQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQI 659
            YQPCDPQVI +R++H+  C  EL   AA R+A+LE S+ LW    E++EAESW ++KE++
Sbjct: 607  YQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 666

Query: 660  YSSLDYG---------------KDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
              +   G                DL+S   L  +HK  + EL G  A L+Q  +    +V
Sbjct: 667  LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELV 726

Query: 705  ARKQFGHPQIEA--------RIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
            A      P  +         R      +W +L++ AA  ++ LQ+A    QF  D D L 
Sbjct: 727  AAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLL 786

Query: 757  AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDS 816
             WL+DA+RL +  D G DE ++R L ++H+    E+E  RG +  L +Q           
Sbjct: 787  DWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAG 846

Query: 817  PDVTH---RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAE 873
            P V     R+    +L+ +V   A LR+Q L++AL +Y +FGE  ACELW+GEKE+WL  
Sbjct: 847  PLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906

Query: 874  MEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLN 933
            M +PD+L+D+EVVQHRF+ LDQEM +LM ++  VN     LVE GHP S EV+  QDHLN
Sbjct: 907  MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966

Query: 934  TRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAI 993
            +RW     LV +R+E + + L V N+ ++  E    + +K + VES    G       A+
Sbjct: 967  SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG------AL 1020

Query: 994  QRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQ 1053
            Q +LSGLE  + A++ R  AL  E+  L +  P Q   + Q  + L   W  L  + Q  
Sbjct: 1021 QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC 1080

Query: 1054 EDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED--MPESLPEAEQLLQQHAGIKDEID 1111
             + +    +LQ FL DLD F  WL   Q+A    +  +P SL EA+ LL +HA +K+E+D
Sbjct: 1081 GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD 1140

Query: 1112 GHQDSYQRVKESGEKVI--QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
              ++ Y R+  + E ++   G      L L + L  L+ GW+ L  +WE+R   L Q   
Sbjct: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200

Query: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
            +Q F +D +QA  +L NQE  L+  E P ++E+ E  +++  DFL +ME ++ K+   V 
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260

Query: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
            +   L+ +GN+Y ++ +E V  + +++++N  +AQ+    L D LELQ+FL++C EL  W
Sbjct: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW 1320

Query: 1290 INDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL 1349
            I++K+L ++D + ++   LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+  A 
Sbjct: 1321 IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 1380

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
            V +KL  + + W EL++TT+ K + L  A  +D  +Q+ A+L+K +  ME QL+  DPG 
Sbjct: 1381 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 1440

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDL 1463
            DL +VN  L KL+ +E QV     E+GEL AQ       P+  E  G+   ++ +R + L
Sbjct: 1441 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 1500

Query: 1464 LEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTL 1523
            LEPL  R++ L +S+   Q++ DL+DE  WV+ERLPLA   + G  LQ VQ  +KKNQ L
Sbjct: 1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 1560

Query: 1524 QNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDA 1583
            + EI  H PR+E+VL+R   L      + + +   L  LQS+W  LREAA  R Q L  A
Sbjct: 1561 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 1620

Query: 1584 NEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL 1643
             + +QYY D  E EAW+GEQEL ++S++  KDE+  + +LK+HL+ ++ VE+Y  +I QL
Sbjct: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 1680

Query: 1644 ASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLE 1703
            + + + LL  GHP+ EQI R Q QVD+ Y  LK++ EER+  LE  Y L+QL R+  +LE
Sbjct: 1681 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740

Query: 1704 QWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHS 1763
             WI+EKE+VA SPE+GQDF+HV++L++KF +FA ETG  G+ER+  VN  ++ LI+ GH+
Sbjct: 1741 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 1800

Query: 1764 EAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE- 1822
             AAT+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F    E+ G I+EK R LP  
Sbjct: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860

Query: 1823 -DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEV 1881
                    +A S  R   AFE +L LL  QV+Q Q+ A +L+T YAGE AEAI ++EQEV
Sbjct: 1861 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 1920

Query: 1882 SAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELL 1941
               W+ LL AC   R  +  TAD  RF S  RDLLSWM+ I  QI   ++PRDVSSVE+L
Sbjct: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980

Query: 1942 MKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEAR 2001
            M YHQG+  E+E R    + C ELG SLL  +   ++EI+ +L ++ +R++E++EKW+  
Sbjct: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040

Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
            WE L+ +LEV QF+++A VA+AWL AQEP L S + G +VD VE+LI+RHEAF K+ A+W
Sbjct: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100

Query: 2062 AERFAALEKPTTLELKERQIAERP 2085
             ERF++L + TT+E  + + +++P
Sbjct: 2101 EERFSSLRRLTTIEKIKAEQSKQP 2124


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score =  869 bits (2245), Expect = 0.0
 Identities = 604/2122 (28%), Positives = 1024/2122 (48%), Gaps = 90/2122 (4%)

Query: 40   FERSRIKALADEREVVQKKTFTKWVNS--HLARVSCRITDLYKDLRDGRMLIKLLEVLSG 97
            +E   I+ L      +Q+KTFTKW+N+     +   +I +LY +L DG  L++LLE++SG
Sbjct: 5    YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64

Query: 98   EMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRF 157
            E LP P++G++R+H LEN  +AL FL+  +V +  +G  +IVDG+  L+LGLIW IILRF
Sbjct: 65   EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123

Query: 158  QIQDIVVQTQE---GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHK 214
            QI  I +  +E        S K+ALL+WCQ KTA Y +VN+T+F+ SW DGL FNALIH 
Sbjct: 124  QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183

Query: 215  HRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFY 274
            HRPDL+D+  L+     HNL  AF VAE++LGI  LLDPEDV    PDE+SI+TYV  +Y
Sbjct: 184  HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243

Query: 275  HYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSL 334
            HY S++       +R+ K++    ETE +  +Y  L +DLL WI +    L +R F +SL
Sbjct: 244  HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303

Query: 335  TGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINR 394
              ++Q L AF+ +RT EKPP+ Q++G  E LLF +Q+ ++A N++ + PH+G  ++++++
Sbjct: 304  PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363

Query: 395  AWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYD 453
             W  LE AE  R  AL+  L++ ++LE LARRF  KAA+RE++L + ++++ Q       
Sbjct: 364  CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423

Query: 454  LAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYL 513
            LA VEAA ++   +E      E R +AL ++A  L +E YH    +  R++ +   W  L
Sbjct: 424  LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483

Query: 514  QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLM 573
             + LQ +R+++    A+  L Q++  +   ++E++    S   G+ L EV +LLQ+H L+
Sbjct: 484  LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543

Query: 574  EADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQL 633
            EA ++  G  V  +   T +     G      +V+Q +   L Q  + L  +   R+A L
Sbjct: 544  EAQVSAHGAHVSHLAQQTAELDSSLG---TSVEVLQAKARTLAQLQQSLVALVRARRALL 600

Query: 634  EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHL 693
            EQ+ +  +F    +E E+W+KE  Q   +   G+DL+ +    +KHKA E E+    A  
Sbjct: 601  EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660

Query: 694  EQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDAD 753
              + +    + AR+    P    R + V   W  L+         LQ A    Q+  DA 
Sbjct: 661  VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720

Query: 754  DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF---- 809
            +  +WL++    L     GQD+ A   L ++H      L      +  LE+Q +      
Sbjct: 721  EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780

Query: 810  ------------------------------------------PEEFRDSPDVTHRLQALR 827
                                                      P+   D   +      L 
Sbjct: 781  SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840

Query: 828  ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMP--DTLEDLEV 885
            + Y+ + A A LR+ RL+EA+ L+         +LW+ EK+  L +   P  DTLE +++
Sbjct: 841  QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL-EKQTVLLQRVQPQADTLEVMQL 899

Query: 886  VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945
                F       K L  +   V+ +A  L +     S ++++ Q+ L+ RW   + L  E
Sbjct: 900  KYENFLTALAVGKGLWAE---VSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956

Query: 946  RREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK-DLGRDLAGIIAI-QRKLSGLERD 1003
            +   +  ++ V ++  +C  T   + D    +E+ +     D    + + Q+K   LER 
Sbjct: 957  KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERR 1016

Query: 1004 VAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQL 1063
            V  +Q+ V  ++ E     +S P Q    GQ +  L+ L + +Q+ +  +     E    
Sbjct: 1017 VHFLQSVV--VKVEEPGYAESQPLQ----GQVET-LQGLLKQVQEQVAQRARRQAETQAR 1069

Query: 1064 QAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
            Q+FLQ+      W    Q  + S+++   +  A++LL++H  + +EI   Q+  Q++ ++
Sbjct: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL-DA 1128

Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
              + +     P+   +   L  L      L  +WE R   L + L  Q+F ++     A 
Sbjct: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188

Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
             +N +  L      + +  A + +++  +F   +     +  +    G KLV   +  + 
Sbjct: 1189 CANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248

Query: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYD 1303
             ++E++Q I+ +  +   ++++    L  +L+LQ + Q+  EL  W+ +K L +      
Sbjct: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308

Query: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDE 1363
              RN+     +H+A  +EL +    +E +   G++L+  +P     +  +L+ L   W+ 
Sbjct: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368

Query: 1364 LQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKR 1423
            L     E+   L  A   +  L+   D  + +  +E  L+S + G+DL S  R+  + ++
Sbjct: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428

Query: 1424 VEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEK-RFLDLLE-PLGRRKKQLESSRAKL 1481
            +E +      ++  L +    M       + + +  R L+LL+  L  R  QL++S    
Sbjct: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELH 1488

Query: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541
            Q       E  WV E +P      Y   L   Q   +K++ LQ E+  H  +V+ VL  G
Sbjct: 1489 QFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548

Query: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601
            + L  +     Q + E+   L+  W  L  A   R Q L+ A   QQY+LD  E E W+ 
Sbjct: 1549 RSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVE 1608

Query: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661
            E+   V S +  +DE   + ++ +H   Q  +  Y  ++++L   AQ L     PE +++
Sbjct: 1609 EKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV 1668

Query: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWI-SEKELVASSPEMGQ 1720
            +  Q ++ +    L+++A  R R+LE    L +  RE +DL+ W+ S+K+       +G+
Sbjct: 1669 V--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGE 1726

Query: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
            D +H   L  KF  F  +   +G +RV       E L++ GHS    + + +  L   W+
Sbjct: 1727 DPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWS 1785

Query: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTA 1840
            +L EL   R   L  +    R      E+L  + EK   LP +V  D    E+  R H  
Sbjct: 1786 ELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQG 1845

Query: 1841 FERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLV 1900
             EREL     Q+Q+  + A R+Q    G +A A+Q ++Q V+ AW  L      RR QL 
Sbjct: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905

Query: 1901 DTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960
                  RF +  RD  SW   + + ++ +E  ++ SS  L +  HQ + AE+E R K + 
Sbjct: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQ 1965

Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
               +LG+  L      ++E++E+L+ +  +R ++ + W  + ERL+   +   F R+   
Sbjct: 1966 QATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGR 2025

Query: 2021 AEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF-------EKSTASWAERFAALEKPTT 2073
             E  L AQE  L +   G +V+ VE+LI++HE F       +K  A+  ER   L +P  
Sbjct: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085

Query: 2074 LE-----LKERQIAERPAEETG 2090
             +     L+ R   +  AE  G
Sbjct: 2086 RDRLPILLQRRMRVKELAESRG 2107



 Score =  502 bits (1293), Expect = e-141
 Identities = 430/1707 (25%), Positives = 753/1707 (44%), Gaps = 66/1707 (3%)

Query: 391  DINRAWESLEEAEYRRELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVA 446
            D+  AW  L E    R  ALR+      + ++ LE L +  ++  ++             
Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825

Query: 447  QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR-ITARKDN 505
             +N   DL  +EA  + H+ +E +    E +++ L + A  ++K     Q   +  R+  
Sbjct: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885

Query: 506  ILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVED 565
            + + W+ LQ  ++ RR +LE    L +    +     W   ++  L   E  +       
Sbjct: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945

Query: 566  LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625
             L  H+ + A++  +    +  T    +     G      + +Q+ +  L+   +++   
Sbjct: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAG---TPTKEVQEELRALQDQRDQVYQT 2002

Query: 626  AAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDE 685
             A ++ +L+  ++   F  E    E  +  +E    +   G  +  V  L RKH+ F   
Sbjct: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKV 2062

Query: 686  LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745
            L   D       +EA      K    P++  R+  +  +  ++K+LA      L  +   
Sbjct: 2063 LTAQDK------KEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLM 2116

Query: 746  FQFQGDADDLKAWLQD-AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ 804
              F   A   + W+Q  A +L      G      + L  KH+ F  E++    VM  + +
Sbjct: 2117 ASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL-LKHQAFEAEVQAHEEVMTSVAK 2175

Query: 805  QAQGF-PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELW 863
            + +    +    + +V+ RLQ LR+ ++ +     LR Q L++  +        D  E W
Sbjct: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235

Query: 864  MGEKEKWLAEMEMPDTLEDLE-VVQHRFDILDQEMKTLMTQIDGVNLAANS--LVESGHP 920
            + EKE    +M + D  +DLE  +Q R  + +    +    +    + + S   ++  + 
Sbjct: 2236 IQEKE---VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292

Query: 921  RSREVK---QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV 977
               EVK   Q +  LN RW +F   +   ++ ++ AL +H    + +  +K I +K  ++
Sbjct: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352

Query: 978  ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037
            ++  D G+DL  +  + RK   LER+V  IQA+V++LERE  +L    PE    +  RQ+
Sbjct: 2353 QAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411

Query: 1038 HLEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM---PE 1091
             + E W  L+   Q +    D L +  +LQA LQ+L      L   Q+  A  D    P 
Sbjct: 2412 EVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL------LVSAQRLRAQMDTSPAPR 2465

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
            S  EA ++L++H   K E+D   DS    + +G++++     P    + Q L GL+   +
Sbjct: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG-HPFSSDIRQVLAGLEQELS 2524

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
            +L   W+     L Q L  Q F    ++ E  L ++E +LA     D L   E  + K +
Sbjct: 2525 SLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHK 2584

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
                 +E    K+ +   +   L   G+  +     + Q +  R      +A      L 
Sbjct: 2585 MLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE 2644

Query: 1272 DNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLEN 1331
            +  +LQ FLQ+ QE+  W+ +K L + +    +   L  +  K Q F AEL +     + 
Sbjct: 2645 ELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQE 2704

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL 1391
            +  EG++L+      +  + ++LE L  LW ELQ  +++K   L  A  +    ++  +L
Sbjct: 2705 LQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEEL 2764

Query: 1392 NKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD 1451
              W+  +E +LR+   G+ L  V  +L   + +E  V+ +  +   L  Q  +   EG  
Sbjct: 2765 ENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824

Query: 1452 ADLSIEK-------RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
                +E+       RF  L EPL  R+  LE+    L+  RD ++E  WV+E+LPLA + 
Sbjct: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQ 2884

Query: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
            DYG +L  V+   +++Q L++E+  H      VL  G +LV+A      ++  R+  L+ 
Sbjct: 2885 DYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944

Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624
            +   LR  AA R   L+ A EAQQ+  +  EA +W+ E+   + S+++    E    +L+
Sbjct: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLR 3004

Query: 1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKR 1684
            R    +R +E +   I++L   A  L S  +PE  +++     V + +A L   AE R  
Sbjct: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064

Query: 1685 KLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQ 1744
             L+    L QL+RET  L+ W++ K   A S + GQD + V +L +KF  F +E  ++GQ
Sbjct: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124

Query: 1745 ERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804
             +V  +      L          I   +  +   W  L + I  R + LAA++++H +  
Sbjct: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184

Query: 1805 TGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQ 1863
              AE+ G + EK   +  ED G   S+  +  + H   EREL  +  +V + Q  A RL 
Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL- 3243

Query: 1864 TAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
                G+   A      +V  AW  L      R   L   A    F    ++LL+W +   
Sbjct: 3244 ----GQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQ 3299

Query: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK 1983
                ++E   DV+  E L+  H+ +  EI           + G+ L+   H  S E+ E 
Sbjct: 3300 ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC 3359

Query: 1984 LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDS 2043
            LQ++  R +E+ E W  RW+R      + +  +    AEAWL   E  L   D+GH+V  
Sbjct: 3360 LQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSD 3419

Query: 2044 VEKLIKRHEAFEKSTASWAERFAALEK 2070
            VE L+ RH+  EK  A+  E+FA ++K
Sbjct: 3420 VELLLHRHQDLEKLLAAQEEKFAQMQK 3446



 Score =  399 bits (1026), Expect = e-110
 Identities = 396/1725 (22%), Positives = 742/1725 (43%), Gaps = 98/1725 (5%)

Query: 384  HDGKLVSDINRAWESLEE------AEYRRELALRNELIRQEKLEQLA-RRFDRKAAMRET 436
            H  KLV   + A  ++ E      A++ R L  R+E  R++ L  L  + + +  A    
Sbjct: 1235 HGEKLVQSQHPAAHTVREQLQSIQAQWTR-LQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293

Query: 437  WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ 496
            W+ E   + A +  G     ++  K+ HEA E++  A    V AL+ + +EL       Q
Sbjct: 1294 WMEEKGLMAAHEPSGARRNILQTLKR-HEAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352

Query: 497  KRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEF 556
            + I  R   +   W  L   +  R   L+     ++L + +  + + +++++  L S+E 
Sbjct: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412

Query: 557  GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
            G+ L   + L ++H+ +E++      K+ A+ +               P ++++   HL 
Sbjct: 1413 GQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLR 1465

Query: 617  QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
            +  E L    A R  QL+ S  L +F    +   SW+ E     S   Y + L     L 
Sbjct: 1466 R-LELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524

Query: 677  RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAA 733
            RKHK  + E++     ++++      + A    GHPQ   I  + +E+   W +L+    
Sbjct: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAAS---GHPQAQHIVEQCQELEGHWAELERACE 1581

Query: 734  FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
               + LQ A  F Q+  D  +L+ W+++   L+S  D G+DE AT  L  KH+   EEL 
Sbjct: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641

Query: 794  ESRGVMEHLEQQAQGF-----PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEA 847
                 ME L+Q AQ       PE+ R   + +  +L+AL+EL       A  R + L+  
Sbjct: 1642 IYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQEL-------AATRDRELEGT 1694

Query: 848  LDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQI 904
            L L+    E +  + W+  +++  A        ED E   H   +F     +++    ++
Sbjct: 1695 LRLHEFLREAEDLQGWLASQKQ--AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752

Query: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV---DSALRVHNYCV 961
                L A SL+E GH     V+Q Q  L T W     L   R  A+   ++ LRVH    
Sbjct: 1753 AACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR--- 1809

Query: 962  DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
            D  E    + +K   + +  ++ RDL G+ A  R   GLER++   + ++  L   + ++
Sbjct: 1810 DLLEVLTQVQEKATSLPN--NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867

Query: 1022 MDSHP-EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
                P  Q   + QRQ+ + + W  LQ+ ++ +   L     L  F   + D+ +W +  
Sbjct: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARV 1927

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
            ++ +  E+  +        L  H  ++ E++  +  +Q+  + G++ +     P    + 
Sbjct: 1928 RQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT-KEVQ 1986

Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
            + L  L    + + + W  +   L      Q F ++  + E IL+ QE +L       S+
Sbjct: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046

Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE--GNLYSDKIKEKVQLIEDRHRK 1258
            E  E  IRK E FL        KVL+  D     + E    L   ++++++ ++  R  +
Sbjct: 2047 EEVEQLIRKHEVFL--------KVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR 2098

Query: 1259 NNEKAQEASVLLRDNLELQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQA 1317
              E A+     L  +L + +F Q   +   WI        + V   + R+     LKHQA
Sbjct: 2099 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158

Query: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA 1377
            F AE+ +HE  + ++  +G+ L+ +       VSQ+L+ L + W++L+     + Q L  
Sbjct: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218

Query: 1378 ARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437
             R+    LQ       WI   E ++   D G+DL    ++  +L+  E + N   + +G+
Sbjct: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR--EFRGNSAGDTVGD 2276

Query: 1438 LFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ--------------- 1482
              A + S+     D  L ++ R  + ++ + +R+ QL +  A                  
Sbjct: 2277 --ACIRSI----SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330

Query: 1483 ---ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
               +SR+L++ T  ++E+  L Q+ D G +L++VQ  ++K++ L+ E+     +VE + +
Sbjct: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390

Query: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAW 1599
               +L + +      L  R   +  SW +LR  A  R + L   ++AQ+  L A   E  
Sbjct: 2391 EVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQK--LQAMLQELL 2448

Query: 1600 IGEQELYVISD--EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE 1657
            +  Q L    D    P+    A  ML+ H   +  ++ +  +I    S  Q LL+AGHP 
Sbjct: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPF 2508

Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
               I ++   +++  + L+   +E + +L+    L       + +E+W+  KE   +S  
Sbjct: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568

Query: 1718 MGQDFDHV--TLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775
            +      +   L + K  ++  E  A    ++  + A    L   GH EA +       +
Sbjct: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQA---GKISALEATARGLHQGGHPEAQSALGRCQAM 2625

Query: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835
                  L     TR   L     L  +     E+   + EK+    E+  LD +   +  
Sbjct: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685

Query: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
            +    F+ EL     Q Q+ Q    RL        +EAIQ + +E+ A W  L D    +
Sbjct: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWGELQDNSQKK 2744

Query: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
              +L    +  R      +L +W+E I  ++      + +  V  L+   + + A ++ +
Sbjct: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKK 2804

Query: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
            ++   A L   ++ ++  H  ++++ E+ ++++ R K + E  + R   L     + +F 
Sbjct: 2805 ARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFF 2864

Query: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
            RDA    AW+  + P  A+ D+G ++ +V  L ++H+  E   +S
Sbjct: 2865 RDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909



 Score =  324 bits (831), Expect = 5e-88
 Identities = 369/1779 (20%), Positives = 738/1779 (41%), Gaps = 71/1779 (3%)

Query: 313  DLLTWIE-QTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQS 371
            +L  W+E QT+ +   +  A++L  +Q + + F T   V K    +   + E L    + 
Sbjct: 872  ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL----RQ 927

Query: 372  RMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKA 431
            R   N+ ++    +     ++++ W  LE  +  + + L + +   E    L      + 
Sbjct: 928  RYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQV 979

Query: 432  AMRETWLSENQRLVAQDNFGYDLA-AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
             +R+  L   Q    Q     D   A++ A+KK       T   E RV  L+ +  ++E+
Sbjct: 980  QLRDVLL---QLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEE 1029

Query: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
              Y + + +  + + +  L   +QE +  R +R   T A Q   Q+    + W + ++A 
Sbjct: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQ 1089

Query: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
            L S E    +   + LL++H+ +  +I +  ++++ + A +            D Q + +
Sbjct: 1090 LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA---ALDCPDSQEVPN 1146

Query: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
             +  L Q  +EL  +   R+  L++   L KF  E+D   +     +      + G+D+ 
Sbjct: 1147 TLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVR 1206

Query: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
              L L ++H+ F   L  L    E +      +V  +      +  +++ + AQW +L+ 
Sbjct: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266

Query: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
             +   ++ L  +    +++ D  +L  W+++   + + E  G      + L K+H+    
Sbjct: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAES 1325

Query: 791  ELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
            EL  +R  +E L+Q  +           D+  RLQ LR  ++ +  +   R   LQ+A  
Sbjct: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385

Query: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
               +  +    +  + + E  L   E    L   + +Q R   L+ E +TL  ++  +  
Sbjct: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445

Query: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
             A+ +  S       +++ Q HL  R +  Q  ++ R   + +++ +H +C        W
Sbjct: 1446 MAHGMAAS----PAILEETQKHLR-RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500

Query: 970  ITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQK 1029
            + +       T      L G  ++ RK   L+ +V A Q +V  +    + L  S   Q 
Sbjct: 1501 VAEHMPHGSPT-SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559

Query: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM 1089
            + I ++ + LE  W  L+++ + +   L +    Q +  D+ + + W+   +  V+S D 
Sbjct: 1560 QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619

Query: 1090 PESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTG 1149
                    +L+ +H  +++E+  +  S + + ++ +  + G   PE   + Q  E L   
Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ-TLTGPEVPEQQRVVQ--ERLREQ 1676

Query: 1150 WNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP-PDSLEAAEAGIR 1208
              AL  +  +R   L   L   EF ++A+  +  L++Q+      E   +  E A     
Sbjct: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736

Query: 1209 KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASV 1268
            KF  F   +E    +V +       L+  G+     ++++ Q ++    +  E  Q    
Sbjct: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
             LRD        ++  E+   + +K  +  +    +   L  +   HQ    EL   E  
Sbjct: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQ 1856

Query: 1329 L-ENIDAEGK-QLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386
            L E ++  G+ Q +   PQ  A V Q+ +A+ + W  LQ   +++   L  AR       
Sbjct: 1857 LQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915

Query: 1387 THADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446
               D   W + +   L+ ++  ++ +S    L+  + +  ++  R+    +L+ Q   +G
Sbjct: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE----KLWQQATQLG 1971

Query: 1447 EEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLED------------ETLWV 1494
            ++   A  +  K   + L  L  ++ Q+  + A+ Q     E             E +  
Sbjct: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031

Query: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD 1554
             + + L  SA  G++++ V+  ++K++    ++L    + E  L+   + +    +    
Sbjct: 2032 AQEVSLKTSA-LGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTLRRPRV---- 2085

Query: 1555 LEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPK 1614
              +RL  L     R++E A  R   L  +     +   A +AE WI      +     P 
Sbjct: 2086 -RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144

Query: 1615 DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYA 1673
            D    +  L +H   +  V+ +   +  +A + + LL+  HP  GE   RLQG + KH+ 
Sbjct: 2145 DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG-LRKHWE 2203

Query: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
             L+     R ++LE+  +  +  +  D  E WI EKE+  +  ++GQD +H   LR + R
Sbjct: 2204 DLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR 2263

Query: 1734 DFARETG--AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
            +F   +    +G   + +++    +L +    E   I + +  LN  WA     +    Q
Sbjct: 2264 EFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQ 2323

Query: 1792 LLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGV 1850
             L  + ++H        +   I EK   +   D G D  + +   R H   ERE+H +  
Sbjct: 2324 QLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQA 2383

Query: 1851 QVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS 1910
            QV+  +    RL    + E A  +++++QEV+ +W  L      RR  L       +  +
Sbjct: 2384 QVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442

Query: 1911 MARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
            M ++LL   + +  Q++T   PR       +++ HQ   AE+++ + + S     G+ LL
Sbjct: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502

Query: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEP 2030
               H  S +IR+ L  +      +   W+    +L+  LE+  F       E WL ++E 
Sbjct: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562

Query: 2031 YLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
             LAS      +  +E L+ +H+  E      A + +ALE
Sbjct: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601



 Score =  299 bits (765), Expect = 2e-80
 Identities = 365/1756 (20%), Positives = 723/1756 (41%), Gaps = 91/1756 (5%)

Query: 396  WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455
            WE+L     R+     +EL +  + EQL R+           L + +  +     G DL 
Sbjct: 1366 WEALN----RKMTERGDELQQAGQQEQLLRQLQDAKEQ----LEQLEGALQSSETGQDLR 1417

Query: 456  AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515
            + +  +K+H+ +E+++     ++ AL  +A  +          I       LR    LQ 
Sbjct: 1418 SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-----PAILEETQKHLRRLELLQG 1472

Query: 516  LLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEA 575
             L  R  +L+ ++ L +        + W+ E   H     + + L   + L +KHK ++ 
Sbjct: 1473 HLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQV 1532

Query: 576  DIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635
            ++     +V+ + ++          Q    Q I ++   LE  + EL      R   L+Q
Sbjct: 1533 EVKAHQGQVQRVLSSGRSLAASGHPQA---QHIVEQCQELEGHWAELERACEARAQCLQQ 1589

Query: 636  SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695
            +    ++F ++ E E W++EK  + SS DYG+D  + L L  KH+A ++EL    + +E+
Sbjct: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649

Query: 696  IFQEAHGMVARKQFGHPQI-EARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADD 754
            + Q A  +   +     ++ + R++E   Q   L++LAA   + L+      +F  +A+D
Sbjct: 1650 LDQTAQTLTGPEVPEQQRVVQERLRE---QLRALQELAATRDRELEGTLRLHEFLREAED 1706

Query: 755  LKAWLQDAHRLLSG-EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEF 813
            L+ WL    +   G E +G+D      L  K   F  ++E     +      A+   E  
Sbjct: 1707 LQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERG 1766

Query: 814  RDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLA 872
              + P V  R Q L+  + ++      R   L++      V  +       + EK   L 
Sbjct: 1767 HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP 1826

Query: 873  EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE-SGHPRSREVKQYQDH 931
                 D L  LE        L++E+     Q+  +   A  + +    P++  V+Q Q  
Sbjct: 1827 NNVARD-LCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885

Query: 932  LNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991
            +   W   Q  + +RR  ++ A  +  +     + + W     + ++  +      +G +
Sbjct: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945

Query: 992  AIQRKLSGLERDVAAIQARVDALERESQ---QLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
                KLS  +   A ++AR    ++ +Q   Q + +     +++ +  + L++    + Q
Sbjct: 1946 ----KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQ 2001

Query: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
            +   +++ L    Q Q FL++    +  L+  + ++ +  +  S+ E EQL+++H     
Sbjct: 2002 TWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLK 2061

Query: 1109 EIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
             +         ++E  + + + +  D   +LL +R+         +  + ESR H L   
Sbjct: 2062 VLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR--------VKELAESRGHALHAS 2113

Query: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
            L    F + A QAE  +      L    PP  L      + K + F   ++ + + + S 
Sbjct: 2114 LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSV 2173

Query: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-LQNFLQNCQEL 1286
               G  L+A+ +  + ++ +++Q +    RK+ E  ++A  L    LE  +NFL+  Q +
Sbjct: 2174 AKKGEALLAQSHPRAGEVSQRLQGL----RKHWEDLRQAMALRGQELEDRRNFLEFLQRV 2229

Query: 1287 TL---WINDKLLTSQ--DVSYD--EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL 1339
             L   WI +K +     D+  D      L  +  + +   A     +  + +I     QL
Sbjct: 2230 DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQL 2289

Query: 1340 MDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAME 1399
             +  P+   ++ Q+   L+  W           Q L  A    +  +   ++ K I   E
Sbjct: 2290 KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKE 2349

Query: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR 1459
              +++ D GKDL SV R+L K + +E +V+  + ++  L  +V  + +   +A   +  R
Sbjct: 2350 ALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHR 2409

Query: 1460 FLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQS--ADYGTNLQT----- 1512
              ++ E   + + + +  R  L      +     ++E L  AQ   A   T+        
Sbjct: 2410 QQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE 2469

Query: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
             +  ++++Q  + E+   T  +      GQQL+ A      D+ + L  L+     L  A
Sbjct: 2470 ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2529

Query: 1573 AAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRA 1632
                  +L+ A E Q +    ++ E W+  +E  + S+ +         +L +H   +  
Sbjct: 2530 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589

Query: 1633 VEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENMYH 1691
            +E     I  L + A+GL   GHPE +  + R Q  + +  A  +  A  R+ +LE +  
Sbjct: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ-AGTRRHRLEELRQ 2648

Query: 1692 LFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751
            L    +++ ++  W+ EK LVA    +  D   +     K ++F  E  A    +   + 
Sbjct: 2649 LQAFLQDSQEVAAWLREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDA-SMHQQQELQ 2706

Query: 1752 AFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILG 1811
               +RL+  GH  +  I E  + L  +W +L +    ++  L  + +  R   +  E+  
Sbjct: 2707 REGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELEN 2766

Query: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQ--VQQFQDVATRLQTAYAGE 1869
             ++      P +V L A T      V  A      LLG Q  ++   D   R   A  G+
Sbjct: 2767 WLE------PIEVELRAPT------VGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ 2814

Query: 1870 K----------AEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWM 1919
                       A+ ++ + + +   +++L +    RRT L   +   +FF  A + ++W+
Sbjct: 2815 AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWV 2874

Query: 1920 ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE 1979
            +  +     Q+  + +S+V  L + HQ + +E+ +        L  G  L+Q  H A+ E
Sbjct: 2875 QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE 2934

Query: 1980 IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  ++QQ+      +  +   R   L+   E  QF  +   A +WL  +   L S D GH
Sbjct: 2935 VAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH 2994

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP---AEETGPQEEEG 2096
            + ++ + L++R EA ++   +++ R   L++   L L+ R+  E P   A+    +E   
Sbjct: 2995 SAEATQALLRRLEATKRDLEAFSPRIERLQQTAAL-LESRKNPESPKVLAQLQAVREAHA 3053

Query: 2097 ETAGEAPVSHHAATER 2112
            E    A    H   E+
Sbjct: 3054 ELLRRAEARGHGLQEQ 3069



 Score =  165 bits (417), Expect = 5e-40
 Identities = 167/813 (20%), Positives = 334/813 (41%), Gaps = 31/813 (3%)

Query: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
            + ++   W  L++   ++   L      Q+  E L  R  R     E WL   +  +   
Sbjct: 2727 LEELGALWGELQDNSQKKVAKL------QKACEAL--RLRRSMEELENWLEPIEVELRAP 2778

Query: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
              G  L  V         +E        +  AL   AQ   +E +   + +  +   +L+
Sbjct: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838

Query: 509  LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
             +  L+E LQ RR  LE    L K F+D    + W+ E      + ++G+ L  V  L +
Sbjct: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
            +H+ +E++++      + +     K  +   +   +   +  R+  LE+    L   AA 
Sbjct: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---VAARVQQLEKAMAHLRAEAAR 2955

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
            R+  L+Q++   +F  E+ EA SW+ E+  +  S D G    +   L R+ +A + +L  
Sbjct: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
                +E++ Q A  + +RK    P++ A+++ V     +L   A      LQ+     Q 
Sbjct: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
            + +   L AWL         +D GQD    + L +K   F +E++       +  ++  G
Sbjct: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135

Query: 809  FPEEFRDSPDVTHRLQALRELYQQVVAQAD----LRQQRLQEALDLYTVFGETDACELWM 864
              E  R +P     +QA R   +    + D     R + L  A ++++        +  M
Sbjct: 3136 TLE--RGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193

Query: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
             EK   +   +   +L  +  +Q +   L++E++ +  ++  +   A  L +        
Sbjct: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG 3253

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
            + + Q+     W   Q    ER + +  A + H +   C+E   W  ++ ++  S+++L 
Sbjct: 3254 LAKVQE----AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA-SSEELA 3308

Query: 985  RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
             D+AG   +  +   L +++   + +   L +E QQL+D+      ++ +  + LE   Q
Sbjct: 3309 EDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQ 3368

Query: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
             L+++   +     E   LQ   Q L+  +AWL+  +  +   D   S+ + E LL +H 
Sbjct: 3369 ELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ 3428

Query: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT- 1163
             ++  +   ++ + +++++       + + E LL  Q L+    G +     W    H  
Sbjct: 3429 DLEKLLAAQEEKFAQMQKT-------EMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQG 3481

Query: 1164 LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196
            L   L      +DAK    +  + E+   HL P
Sbjct: 3482 LGAQLAETRDPQDAKGTPTMEGSLEFK-QHLLP 3513



 Score =  143 bits (361), Expect = 2e-33
 Identities = 140/601 (23%), Positives = 259/601 (43%), Gaps = 23/601 (3%)

Query: 297  AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
            A+E   ++ K+   A + + W+++ + +  ++ +  SL+ V + LQ    ++ +E     
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--EQHQNLESEMSS 2909

Query: 357  QEKGNLEVLLFTIQSRMRANNQKVYTPHD-GKLVSDINRAWESLEEAEYRRELALRNELI 415
             E     V+L T    ++A +   +  H+    V  + +A      A  R E A R  L+
Sbjct: 2910 HE-ALTRVVLGTGYKLVQAGH---FAAHEVAARVQQLEKAM-----AHLRAEAARRRLLL 2960

Query: 416  RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
            +Q    Q A++F  +     +WL+E   ++  ++ G+   A +A  ++ EA + D  A+ 
Sbjct: 2961 QQ---AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017

Query: 476  ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
             R+  L+  A  LE     +  ++ A+   +    + L    ++R   L+  L L +L +
Sbjct: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLER 3077

Query: 536  DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFT 595
            + L    W+    A   S ++G+ L  V+ L +K      ++   G + K      L  T
Sbjct: 3078 ETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG-QAKVYALRKLAGT 3136

Query: 596  EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655
              +G     P  IQ + S +E  +E L      R   L  +  +  F     E +  ++E
Sbjct: 3137 LERGAPRRYPH-IQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195

Query: 656  KEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIE 715
            K  +    D G  L+SV  LQ++H+  E EL  ++  + ++  EA     R    HP   
Sbjct: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----CRLGQLHPAAP 3251

Query: 716  ARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDE 775
              + +V   W  L+  A    + L  A     F G   +L AW Q+   L S E++ +D 
Sbjct: 3252 GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311

Query: 776  GATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVV 834
                 L  +H++  +E+ E R   + L Q+ Q   +     S +VT  LQ L    Q++ 
Sbjct: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371

Query: 835  AQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILD 894
                LR QR  E+  L  +    +  E W+   E  L + +   ++ D+E++ HR   L+
Sbjct: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431

Query: 895  Q 895
            +
Sbjct: 3432 K 3432


>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
            sapiens]
          Length = 678

 Score =  577 bits (1488), Expect = e-164
 Identities = 304/653 (46%), Positives = 424/653 (64%), Gaps = 8/653 (1%)

Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353
            +L ++D + ++   LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+  A V +K
Sbjct: 1    MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60

Query: 1354 LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTS 1413
            L  + + W EL++TT+ K + L  A  +D  +Q+ A+L+K +  ME QL+  DPG DL +
Sbjct: 61   LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120

Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDLLEPL 1467
            VN  L KL+ +E QV     E+GEL AQ       P+  E  G+   ++ +R + LLEPL
Sbjct: 121  VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180

Query: 1468 GRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527
              R++ L +S+   Q++ DL+DE  WV+ERLPLA   + G  LQ VQ  +KKNQ L+ EI
Sbjct: 181  QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240

Query: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587
              H PR+E+VL+R   L      + + +   L  LQS+W  LREAA  R Q L  A + +
Sbjct: 241  QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300

Query: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647
            QYY D  E EAW+GEQEL ++S++  KDE+  + +LK+HL+ ++ VE+Y  +I QL+ + 
Sbjct: 301  QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360

Query: 1648 QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWIS 1707
            + LL  GHP+ EQI R Q QVD+ Y  LK++ EER+  LE  Y L+QL R+  +LE WI+
Sbjct: 361  RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420

Query: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
            EKE+VA SPE+GQDF+HV++L++KF +FA ETG  G+ER+  VN  ++ LI+ GH+ AAT
Sbjct: 421  EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480

Query: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE--DVG 1825
            +AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F    E+ G I+EK R LP      
Sbjct: 481  MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540

Query: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAW 1885
                +A S  R   AFE +L LL  QV+Q Q+ A +L+T YAGE AEAI ++EQEV   W
Sbjct: 541  EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600

Query: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSV 1938
            + LL AC   R  +  TAD  RF S  RDLLSWM+ I  QI   ++PR  SS+
Sbjct: 601  KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653



 Score =  161 bits (407), Expect = 7e-39
 Identities = 131/650 (20%), Positives = 274/650 (42%), Gaps = 7/650 (1%)

Query: 444  LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
            L+A+D    D   +     +H+A   + A  +E +  +E   Q+L +E       +  + 
Sbjct: 2    LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61

Query: 504  DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
              I + W+ L+   Q++ ++L       +L Q        +  +++ L   + G  L  V
Sbjct: 62   GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
               L+K + ME+ +     +V  + A T         +P   +++ +R + + +    L 
Sbjct: 122  NSQLKKLQSMESQVEEWYREVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLL 177

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
                 R+  L  SK L +   ++D+  +W++E+  +    + G  L +V    +K++   
Sbjct: 178  EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743
             E++     LE++ + A  + + +      +   ++++ + W  L++ A   ++ L  A 
Sbjct: 238  REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297

Query: 744  NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLE 803
               Q+  D  +++AWL +   L+  ED G+DE +T  L KKH    + +E     +  L 
Sbjct: 298  QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357

Query: 804  QQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL 862
            +Q +   E    DS  ++ R   +  LY  +    + R+  L++   LY +  +    E 
Sbjct: 358  RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH 417

Query: 863  WMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL-MTQIDGVNLAANSLVESGHPR 921
            W+ EKE      E+    E + V+Q +F     E       ++  VN   + L+E GH  
Sbjct: 418  WIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTA 477

Query: 922  SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
            +  + +++D LN  W     L+  R + + ++  +H +  D  E    I +K + +    
Sbjct: 478  AATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537

Query: 982  DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLE 1040
                      ++QR L   E D+  + ++V  L+  + QL   +  E  E I  R++ + 
Sbjct: 538  TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL 597

Query: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090
            + W+ L  + +     +   +    F   + D  +W+      + + D P
Sbjct: 598  QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647



 Score =  105 bits (261), Expect = 6e-22
 Identities = 125/664 (18%), Positives = 278/664 (41%), Gaps = 42/664 (6%)

Query: 765  LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRD-SPDVTHRL 823
            L++ +   +D         +H+ F+ EL +++  +E +E++ Q   +E  + +  V  +L
Sbjct: 2    LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61

Query: 824  QALRELYQQVVAQADLRQQRLQEAL---DLYTVFGETDACELWMGEKEKWLAEMEMPDTL 880
              +R+ + ++ +    + ++L EA     L   F E D   L M   E  L +++    L
Sbjct: 62   GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM---ESQLQDVDPGGDL 118

Query: 881  EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAF 939
              +     +   ++ +++    ++    L A +      P S+E V + Q+ +  R    
Sbjct: 119  ATVNSQLKKLQSMESQVEEWYREVG--ELQAQTAALPLEPASKELVGERQNAVGERLVRL 176

Query: 940  QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
               + ERR  + ++  +H    D ++   W+ ++  +   T + G  L  +    +K  G
Sbjct: 177  LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT-ERGNGLQAVQQHIKKNQG 235

Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE 1059
            L R++ A   R++ +   +  L      + E + +  + L+  W GL+++ + ++ +L  
Sbjct: 236  LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 295

Query: 1060 VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQR 1119
              Q++ +  D+ + +AWL   +  + SED  +      QLL++H  ++  ++ +++S  +
Sbjct: 296  AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355

Query: 1120 VKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK 1178
            +      +++ G  D E   + +R   +D  + AL  + E R   L Q     +  +   
Sbjct: 356  LSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS 413

Query: 1179 QAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSM-ENNRDKVLSPVDSGNKLVAE 1237
            + E  ++ +E      E     E       KF +F        R+++ +     ++L+  
Sbjct: 414  ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 473

Query: 1238 GNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK---- 1293
            G+  +  + E    + +   +  E     + LL  + EL  F  + +EL   I +K    
Sbjct: 474  GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533

Query: 1294 -LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQF------ 1346
              LT+       A ++             L + E  L+ + ++ +QL +   Q       
Sbjct: 534  PRLTTPPEPRPSASSMQR----------TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 583

Query: 1347 ---TALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQL 1402
                A+ S++ E L   W EL +  ++   H+S+   + LR  +   DL  W+  +  Q+
Sbjct: 584  EHAEAIASREQEVLQG-WKELLSACEDARLHVSSTADA-LRFHSQVRDLLSWMDGIASQI 641

Query: 1403 RSDD 1406
             + D
Sbjct: 642  GAAD 645



 Score = 95.9 bits (237), Expect = 4e-19
 Identities = 111/483 (22%), Positives = 206/483 (42%), Gaps = 28/483 (5%)

Query: 287 GKRVGKVIDHAIETEKMI---EKYSGLASDL---LTWIEQTITVLNSRKFANSLTGVQQQ 340
           G+R+ ++++   E  +++   ++   +A DL   L W+++ + +    +  N L  VQQ 
Sbjct: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229

Query: 341 LQAFSTYRTVEKPPKFQEKG-NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESL 399
           ++     R      + Q  G  LE +L    +     + +      G  +  +  AW  L
Sbjct: 230 IKKNQGLRR-----EIQAHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGL 282

Query: 400 EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEA 459
            EA  RR+  L        ++EQ    FD   A  E WL E + L+  ++ G D  +   
Sbjct: 283 REAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334

Query: 460 AKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQS 519
             KKH  +E     YEE +  L    + L +  + D ++I+ R+  + RL+  L+EL + 
Sbjct: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394

Query: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
           RR  LE    L +L + +     W+ E +    S E G+    V  L +K     ++  +
Sbjct: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454

Query: 580 QG-DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKR 638
            G +++ A+     +  E  G+       + +    L + + EL  +   R   L  S+ 
Sbjct: 455 AGRERLAAVNQMVDELIE-CGHTAA--ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511

Query: 639 LWKFFWEMDEAESWIKEKEQIYSSLDYGKD-LTSVLILQRKHKAFEDELRGLDAHLEQIF 697
           L KFF +  E +  I+EK +    L    +   S   +QR  +AFE +L+ L + + Q+ 
Sbjct: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571

Query: 698 QEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
           + A  +       H + I +R +EV   W +L       + ++    +  +F     DL 
Sbjct: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631

Query: 757 AWL 759
           +W+
Sbjct: 632 SWM 634



 Score = 87.8 bits (216), Expect = 1e-16
 Identities = 98/455 (21%), Positives = 196/455 (43%), Gaps = 14/455 (3%)

Query: 1624 KRHLRQQRAVEDYGRN---IKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
            KR LR Q  + +  +N   ++++    Q L+         + +  G++ + +A L+   +
Sbjct: 17   KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76

Query: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
             + R+L       QL +   +L++ +   E      + G D   V     K +    +  
Sbjct: 77   AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136

Query: 1741 AIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDL 1799
               +E V  + A    L ++    E   + E ++ + E    LLE +  R +LL AS +L
Sbjct: 137  EWYRE-VGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKEL 193

Query: 1800 HRYFYTGAEILGLIDEK-HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
            H+  +   + L  + E+    +  + G      +   + +    RE+   G ++++  + 
Sbjct: 194  HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253

Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFR--FFSMARDLL 1916
            A  L +  + E AEA++   +++ +AW  L +A A RR Q++D A +    +F +A ++ 
Sbjct: 254  AGALASLRSPE-AEAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVA-EVE 310

Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
            +W+      + ++++ +D  S   L+K H  +   +E   ++ +       +LL+  H  
Sbjct: 311  AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370

Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
            SE+I  +  QV      + E  E R   L     + Q SR  S  E W+  +E    S +
Sbjct: 371  SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430

Query: 2037 FGHTVDSVEKLIKRHEAFEKSTA-SWAERFAALEK 2070
             G   + V  L ++   F   T  +  ER AA+ +
Sbjct: 431  LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 465



 Score = 37.7 bits (86), Expect = 0.12
 Identities = 25/128 (19%), Positives = 52/128 (40%)

Query: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWER 2004
            HQ   AE+    +        G+ L+Q + + +  +R+KL ++     E+    +A+  +
Sbjct: 22   HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81

Query: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
            L    +  Q  +  +  +  L+  E  L   D G  + +V   +K+ ++ E     W   
Sbjct: 82   LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141

Query: 2065 FAALEKPT 2072
               L+  T
Sbjct: 142  VGELQAQT 149



 Score = 35.8 bits (81), Expect = 0.46
 Identities = 51/279 (18%), Positives = 106/279 (37%), Gaps = 13/279 (4%)

Query: 278 SKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337
           S++  L V  K +G+    A+E +  + + S   S+L  WI +   V  S +       V
Sbjct: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438

Query: 338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWE 397
               + FS + +         +  L  +   +   +   +    T  + K    +N AW 
Sbjct: 439 SVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK--DGLNEAWA 493

Query: 398 SLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAV 457
            L E      +  R +L+   +  +L + F     ++     + +RL           + 
Sbjct: 494 ELLEL-----MGTRAQLLAASR--ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 546

Query: 458 EAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-KRITARKDNILRLWSYLQEL 516
            + ++   A E D      +VR L++ A +L      +  + I +R+  +L+ W  L   
Sbjct: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606

Query: 517 LQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAE 555
            +  R  + +T    +    +   + WMD I + + +A+
Sbjct: 607 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645


>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 2 [Homo sapiens]
          Length = 2472

 Score =  574 bits (1479), Expect = e-163
 Identities = 450/1732 (25%), Positives = 806/1732 (46%), Gaps = 146/1732 (8%)

Query: 355  KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414
            K Q+    E  L   QSR+ A  +       G+ + D+N   +    A     ++L  +L
Sbjct: 610  KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663

Query: 415  IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
            +   +L+ +  R       F+R     E WL E +  +A D++G DL  V+  +KKH  +
Sbjct: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723

Query: 468  ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527
            E D AA+++R+  +   A++ +   + D + I  +++ ++  +  L+E + +R+Q+L  +
Sbjct: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783

Query: 528  LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587
            L LQ+LF+D+     W+ E +    S   GK L+ V++LL+KH+ ++A+IA    ++KA+
Sbjct: 784  LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843

Query: 588  TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647
            T       E   +   D   ++ ++  L Q +E L   A+ R+  LE S +  ++F + +
Sbjct: 844  TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900

Query: 648  EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707
            EAESW++EKE I  S DYGKD  S   L +KH+A   +L    + ++ + ++A     R+
Sbjct: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958

Query: 708  QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761
            Q      E   + V A +D Q K       K      L ++ N   ++ + +D + ++  
Sbjct: 959  QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018

Query: 762  AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821
            A+               + L        E L E +G +   ++Q        +++  V+ 
Sbjct: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064

Query: 822  RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881
            R++ + ELY  ++   + R+  L+++   + +F E +  + W+ EKE  L   E+   LE
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124

Query: 882  DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931
             +EV+Q +FD   +++K   +++  +N  A  L ES    + EV+  Q            
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183

Query: 932  ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
                                       LN RW++ Q L  ER + + SA  V  +  D +
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243

Query: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024
            ET +WI +K + + +T + G DLA + A+QRK  G ERD+AA+  +V++L   +++L+ S
Sbjct: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302

Query: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084
            HPE  ED+ ++   L + W  L +    ++  LG+   LQ FL D  D  +W++  +  V
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362

Query: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142
            +S+++ + +  AE LL++H   + EID    ++Q  ++ G++++       PE   + Q+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419

Query: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202
            L+ LD     L + W  R   L QCL  Q F +D +QAE  ++ +E  L   +  DSL++
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479

Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
             EA I+K EDF  ++    +K+ +     ++L+A G+     I  +   + DR R+   +
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539

Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAEL 1322
              E    L ++  LQ F ++  E+  WI++KL T+ D SY +  N+ +K  KHQAF AEL
Sbjct: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAEL 1599

Query: 1323 ASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
             ++   +  +   G  L++      +   V  +L AL   W  L   + EK+Q L  A  
Sbjct: 1600 HANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK 1659

Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
                     D + W+S +E  L S+D GKDL SVN +L K + +E  ++  ++ L +L +
Sbjct: 1660 QQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNS 1719

Query: 1441 QVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLW 1493
            Q  S+            D   +I  RF  +      R+ +L  S    Q  RD++DE  W
Sbjct: 1720 QADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1779

Query: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQ 1553
            ++E+  L  S DYG +L  VQ   KK++ L+ E+  H P ++ VL  G++L +   I  +
Sbjct: 1780 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1839

Query: 1554 DLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIP 1613
            ++++RL      W  L++ AA R QRL ++ E QQ+  + +E EAWI E+   V S++  
Sbjct: 1840 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1899

Query: 1614 KDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYA 1673
                    +LK+H   +     +   +  + +  Q L+   +   E I      ++   +
Sbjct: 1900 DTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVS 1959

Query: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
             L+  A +RK KL+      Q   + D +E WI EKE    + + G+D   V  L  K  
Sbjct: 1960 DLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQE 2019

Query: 1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
             F     A  QE + N+ A  ++L+ A H ++  I      L + W+ LL     R + L
Sbjct: 2020 TFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL 2079

Query: 1794 AASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
                              L  + H    ED+ L      +F +  +AF            
Sbjct: 2080 ------------------LEAQSHFRKVEDLFL------TFAKKASAFN----------S 2105

Query: 1854 QFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913
             F++    L         E I+   +E   A+++ L +      QL +   + + F +A 
Sbjct: 2106 WFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVAS 2164

Query: 1914 DLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA----EIET 1954
            +  +W            ++ II++ E +   E+ R   + +L  ++ Q  NA      ET
Sbjct: 2165 NPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQET 2224

Query: 1955 RSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
            R+     +C+      L+ Q +A++   ++++ + S+ K++ +   A  E L
Sbjct: 2225 RTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2276



 Score =  519 bits (1337), Expect = e-146
 Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)

Query: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
            I+ R ++V  ++ + K+L+   ++ L+D+  F  FQ DA++L+ W+Q+  ++ S E+   
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72

Query: 774  DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830
             +  T   GK  KH+ F  E++ + G +  L++       E    S  +  RL  L   +
Sbjct: 73   -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
            + ++ +   +  +L +A  L     E +    W+ +KE  +   E+   LE +EV+Q +F
Sbjct: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191

Query: 891  DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
            +    +M     +++ VN  A  L++  HP    +K  QD +N  WQ  + L  +R+  +
Sbjct: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251

Query: 951  DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
              A  V  +  D +ET  WI +K +++ S  D GRDLA + A+ RK  GLERD+AA++ +
Sbjct: 252  FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310

Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
            V AL  E+ +L  SHP     I  +++ L   W+ ++     +   L +  +LQ FL D 
Sbjct: 311  VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370

Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
             D  +W++  +  + ++++   +  AE LL +H   K EID H+DS++   ESG+ ++  
Sbjct: 371  RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430

Query: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
                +D     + ++L  L     AL  +WE R     QC+  Q F +D +Q +  +S Q
Sbjct: 431  GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486

Query: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
            E  L + +  DSL++ EA ++K EDF  S+    +K+ +  +   KL+   +   + +  
Sbjct: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546

Query: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
            +   +  R    +E+A      L D+  LQ F ++  EL  W+N+K+ T+ D +Y +  N
Sbjct: 547  RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606

Query: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367
            L  K  KHQAF AEL++++  ++ ++  G++L+D        V+ ++  +  LW +L   
Sbjct: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666

Query: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427
            T+ K   L  A       +   D+  W+  +E  L SDD GKDLT+V  +  K   +E  
Sbjct: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726

Query: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480
            V   ++ +  +  Q     + G     +I+K       R+  L EP+  RK++L  S   
Sbjct: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786

Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
             Q+ RD+EDE  W+ E+ P+A S + G +L  VQ  +KK+Q LQ EI GH PR++ V Q+
Sbjct: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846

Query: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
            G  +VE      +D++ +L  L   W+ L+  A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 847  GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906

Query: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
             E+E  V S +  KDE+ A  +LK+H      +  YG +I+ L  +AQ          +Q
Sbjct: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959

Query: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709
            +     +  K     L D  E+  R+          L N  +    K E +D + ++   
Sbjct: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019

Query: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769
             +    P   Q      LL ++       + A+ QE++DN     +        EA +++
Sbjct: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063

Query: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828
                 + E++  LLEL + R  +L  S      F    E+   I+EK   L  E+VG D 
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123

Query: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878
               E   +    F+++L     +++    VA  L++     E+ +A+Q +E         
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183

Query: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912
                                     +E++  W++L    A  R+QL+ +A +  RF   A
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242

Query: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972
             +   W+E   + + T     D++SV+ L + H+G   ++       ++  E  E L+Q 
Sbjct: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302

Query: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032
              +++E+++EK  ++      + ++ + R  +L    ++ +F  D     +W+      +
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362

Query: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
            +S +    V   E L++RH+       + A  F A E+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400



 Score =  476 bits (1226), Expect = e-134
 Identities = 405/1850 (21%), Positives = 811/1850 (43%), Gaps = 123/1850 (6%)

Query: 274  YHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFAN- 332
            YH F ++  L  +           +E     + +   A +L  WI++ + + +   + + 
Sbjct: 26   YHRFKELSTLRRQ----------KLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP 75

Query: 333  -SLTGVQQQLQAFSTYRTVEKPP--KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
             +L G  Q+ QAF            K  E GNL +      S     ++ + T      +
Sbjct: 76   TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI------SEGHFASETIRTR-----L 124

Query: 390  SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
             +++R WE L   E  RE  ++  L++ +KL Q  R  +        W+++ + +V  + 
Sbjct: 125  MELHRQWELL--LEKMREKGIK--LLQAQKLVQYLRECEDVM----DWINDKEAIVTSEE 176

Query: 450  FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
             G DL  VE  +KK E  +TD AA+EERV  +   A +L +E + +++ I  ++D +   
Sbjct: 177  LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236

Query: 510  WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
            W  L+ L   R+ +L     +Q+  +D+  +I W+ E +  + S +FG+ L  V+ LL+K
Sbjct: 237  WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296

Query: 570  HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
            H+ +E D+A   DKVKA+ A   +  +     P     IQ +   L   +E++  +AA R
Sbjct: 297  HEGLERDLAALEDKVKALCAEADRLQQS---HPLSATQIQVKREELITNWEQIRTLAAER 353

Query: 630  KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
             A+L  S RL +F  +  +  SW+ E + + ++ +   D+     L  +H+  + E+   
Sbjct: 354  HARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAH 413

Query: 690  DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
            +   +   +    ++A   +   ++  ++  +S +   L +L    ++  +   +   F 
Sbjct: 414  EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFY 473

Query: 750  GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
             D + +  W+      L  ED+G    +  AL KKH+DF + L      +  L++ A   
Sbjct: 474  RDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKL 533

Query: 810  PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
             +    +  DV  R  AL      +  +A  R+ +L ++  L   F ++D  + W+ EK 
Sbjct: 534  IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKM 593

Query: 869  KWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQY 928
            K   +    D   +L+    +    + E+    ++ID +  A   L++  H    EV   
Sbjct: 594  KTATDEAYKDP-SNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652

Query: 929  QDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLA 988
             + + + W+        +   +  A +   +  + E+   W+ +    + S  D G+DL 
Sbjct: 653  MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLT 711

Query: 989  GIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
             +  +Q+K + LE DVAA Q R+D +  +++Q  D+     E+I ++Q+ L   ++ L++
Sbjct: 712  NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771

Query: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
             +  ++  L +  +LQ   +D++D + W+   +   AS +  + L   + LL++H  ++ 
Sbjct: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831

Query: 1109 EIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
            EI GH+   + V + G  +++ G    E +    +L  L+  W AL      R   L   
Sbjct: 832  EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQRRQDLEDS 889

Query: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
            L  Q++  DA +AE+ +  +E  +   +     ++AEA ++K E  +          LS 
Sbjct: 890  LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD--------LSA 941

Query: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELT 1287
              S  + + E    +   +++V   +D      E  +E  + L D  E     ++ +E+T
Sbjct: 942  YGSSIQALRE---QAQSCRQQVAPTDD------ETGKELVLALYDYQE-----KSPREVT 987

Query: 1288 LWIND--KLLTSQDVSYDEARNLHNKWLKHQAFVAEL-----ASHEGWLENID--AEGKQ 1338
            +   D   LL S +  + +      +     A+V +L     AS E  LE     A  ++
Sbjct: 988  MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQE 1047

Query: 1339 LMDEKPQFT---ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWI 1395
             +D + + T     VS +++ +  L+  L    +++   L  +    +  +   +L +WI
Sbjct: 1048 QIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWI 1107

Query: 1396 SAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDAD-- 1453
            +  E  L S++ G DL  V  +  K    +  +   +  L ++      +  EG  A+  
Sbjct: 1108 NEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEV 1167

Query: 1454 -----------------------------------------LSIEKRFLDLLEPLGRRKK 1472
                                                       + +R+  L +    R +
Sbjct: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227

Query: 1473 QLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTP 1532
             L S+    +  RD ++   W+EE+     + +YG +L +VQ   +K++  + ++     
Sbjct: 1228 LLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD 1287

Query: 1533 RVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
            +V  + +  ++L+++     +DL+E+   L  +W  L + A  R  +L D+++ Q++  D
Sbjct: 1288 KVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSD 1347

Query: 1593 ADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652
              +  +WI      V SDE+ KD  GA  +L+RH   +  ++      +      Q LL+
Sbjct: 1348 FRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA 1407

Query: 1653 AGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELV 1712
             GH    +I +    +D+  A L+    +R+  L+    L    R+ +  E W++ +E  
Sbjct: 1408 HGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467

Query: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWK 1772
             ++ + G   D V  L  K  DF +    + +E++  + AF ++LI AGH     I+  +
Sbjct: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526

Query: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE 1832
            + + + W  L   +  +   L  S  L ++     EI   I EK +   ++   D +  +
Sbjct: 1527 NEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ 1586

Query: 1833 SFHRVHTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
            S H+ H AFE ELH    +++   D+   L  + A AG + +A++ +   ++  WQ L+ 
Sbjct: 1587 SKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQ 1645

Query: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
              A +  +L +   +  F +  +D   W+  +   + +++  +D++SV  L+K HQ + A
Sbjct: 1646 KSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEA 1705

Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLE 2010
            +I              +SL+      + ++++K   +  R +++     +R  +L     
Sbjct: 1706 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR 1765

Query: 2011 VCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
            + QF RD    E+W+  ++  + S D+G  +  V+ L K+H+  E   A+
Sbjct: 1766 LHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1815



 Score =  474 bits (1220), Expect = e-133
 Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)

Query: 608  IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
            IQ+R   +   +     ++  R+ +LE S R   F  + +E E WI+EK QI S  +Y K
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73

Query: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
            D T++    +KH+AFE E++     + ++ +  + M++   F    I  R+ E+  QW+ 
Sbjct: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133

Query: 728  LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
            L +        L  A+   Q+  + +D+  W+ D   +++ E++GQD      L KK ++
Sbjct: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193

Query: 788  FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846
            F  ++      +  + Q A    +E     ++    Q  +   +Q++   A  RQ +L  
Sbjct: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253

Query: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
            A ++     + D    W+ EKE+ +A  +    L  ++ +  + + L++++  L  ++  
Sbjct: 254  AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313

Query: 907  VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
            +   A+ L +S    + +++  ++ L T W+  +TL +ER   ++ + R+  +  D  + 
Sbjct: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373

Query: 967  SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
            + W+T+  K + +  +L  D+AG  A+  +    + ++ A +    + +   Q L+ +  
Sbjct: 374  TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432

Query: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
               +++ ++   L E    L +  + +     +   LQ F +D +    W+S  +  + +
Sbjct: 433  YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492

Query: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144
            ED+ +SL   E LL++H   +  +   ++    + E   K+IQ      Y +  +  R +
Sbjct: 493  EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549

Query: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202
             L +  NAL      R   LA     Q+F +D+ + ++ ++ +  T      + P +L+ 
Sbjct: 550  ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609

Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
                ++K + F   +  N+ ++ +   +G KL+   +   D++  ++  +    +K  E 
Sbjct: 610  K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666

Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320
             +   + LR+  + Q F +N +++ LW+ +    L S D   D   N+ N   KH    A
Sbjct: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725

Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
            ++A+H+  ++ I  + +Q  D        + +K EAL   ++ L+     + Q L+ +  
Sbjct: 726  DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785

Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
                 +   D   WI   E    S + GKDL  V  +L K + ++ ++   +  +  +  
Sbjct: 786  LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845

Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493
            +  +M EEG  A   ++ +  +L +          +R++ LE S    Q   D  +   W
Sbjct: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905

Query: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549
            + E+ P+  S DYG +  + +  +KK++ L +++  +   ++ + ++ Q    Q+    +
Sbjct: 906  MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965

Query: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608
               ++L   L   Q    R      G +  L ++     + ++ ++ + ++    +  + 
Sbjct: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025

Query: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663
                 S E   +E+G+I +      +Q  +++  R  K+  S +              +R
Sbjct: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065

Query: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723
            ++ QV++ Y  L ++ E+RK  LE     F L RE ++L+QWI+EKE   +S E+G D +
Sbjct: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124

Query: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762
             V +L+ KF DF ++  A  + R+ ++N   E L   G                      
Sbjct: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183

Query: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807
            +++ T + WK                 LNE W  L +L + R QLL +++++ R+     
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243

Query: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866
            E    I+EK++ L  D  G D ++ ++  R H  FER+L  LG +V    + A RL  ++
Sbjct: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303

Query: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926
              E AE +Q K  E++ AW +L      R+ +L D+ D  RF S  RDL+SW+  I   +
Sbjct: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362

Query: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986
             + E  +DV+  E L++ HQ    EI+ R+  F A  + G+ LL   H AS EI++KL  
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422

Query: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
            +   R ++ + W  R   L   LE+  F RD   AE W+ A+E +L + D G ++DSVE 
Sbjct: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482

Query: 2047 LIKRHEAFEKSTASWAERFAALE 2069
            LIK+HE F+K+     E+ AAL+
Sbjct: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505



 Score =  463 bits (1192), Expect = e-130
 Identities = 381/1740 (21%), Positives = 781/1740 (44%), Gaps = 100/1740 (5%)

Query: 397  ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447
            E+ E+ + RR+  L           +R++KLE   R   F R A   E W+ E  ++ + 
Sbjct: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69

Query: 448  DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507
            +N+  D   ++   +KH+A E +  A    +  L++    +  E +   + I  R   + 
Sbjct: 70   ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128

Query: 508  RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567
            R W  L E ++ +  +L     L +  ++    +DW+++ +A + S E G+ L  VE L 
Sbjct: 129  RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188

Query: 568  QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627
            +K +  + D+A   ++V  +     K  +    Q  + ++I+ +   +   ++ L  +A 
Sbjct: 189  KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245

Query: 628  GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687
             R+ +L  +  + +F  ++DE  SWIKEKEQ+ +S D+G+DL SV  L RKH+  E +L 
Sbjct: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305

Query: 688  GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747
             L+  ++ +  EA  +         QI+ + +E+   W+Q++ LAA     L D+    +
Sbjct: 306  ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365

Query: 748  FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
            F  D  DL +W+ +   L++ +++  D     AL  +H++   E++      +  ++  Q
Sbjct: 366  FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425

Query: 808  G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
                     S +V  +L  L E    ++   +LR+Q+ ++ +DL   + +T+  + WM +
Sbjct: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485

Query: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
            +E +L   ++ D+L+ +E +  + +  ++ +     +I  ++  A  L+++ H    +V 
Sbjct: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545

Query: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
              +D L +R  A       RR  +  +  +  +  D +E   W+ +K K   +T +  +D
Sbjct: 546  TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603

Query: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
             + +    +K    E +++A Q+R+DALE+  Q+L+D +   K+++  R   +  LW+ L
Sbjct: 604  PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663

Query: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
             ++ + +   L E +Q Q F ++++D + WL   +  +AS+D  + L   + L ++HA +
Sbjct: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723

Query: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            + ++  HQD    +  ++ +    G  D E   + ++ E L   + AL     +R   LA
Sbjct: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
              L  Q+  +D +  E  +  +E   A       L   +  ++K +     +  +  ++ 
Sbjct: 782  DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841

Query: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
            +    GN +V EG+  ++ +K K+  +  +      KA +    L D+L+ Q +  +  E
Sbjct: 842  AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901

Query: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343
               W+ +K  ++ S D   DE  +      KH+A +++L+++     +I A  +Q    +
Sbjct: 902  AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957

Query: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401
             Q      +   E +  L+D  + + +E T      +   L L    + + W   + D+ 
Sbjct: 958  QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013

Query: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
                   ++  DP +  +  N     L   +  + +R+E++         + +E G   L
Sbjct: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064

Query: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511
                +E+ +  LLE   +RK  LE S  K  + R+  +   W+ E+     S + G +L+
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124

Query: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560
             V++  KK    Q ++  +  R++D+ +  + L    + A E+     +E  G       
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184

Query: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
                                      L   W  L++ A  R Q L  A+E Q+++ DADE
Sbjct: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
             + WI E+   + +D    D      + ++H   +R +   G  +  L   A+ L+ + H
Sbjct: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303

Query: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714
            PE  E +     ++++ ++ L   A++RK KL + + L +   +  DL  WI+    + S
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363

Query: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771
            S E+ +D      L ++ ++   E  A    R     AF    ++L+  GH  +  I + 
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419

Query: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830
             D L++  ADL +    R  +L    +L  +     +    +  +   L  ED G    +
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479

Query: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
             E+  + H  F++ +++   ++   Q  A +L  A    K + I ++  EV   W+ L  
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538

Query: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
                +R++L ++    +F     ++ +W+   + Q  + E  +D ++++   + HQ   A
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKL-QTASDESYKDPTNIQSKHQKHQAFEA 1597

Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWERLRML 2008
            E+   +      +++G SL++R   A  E  ++ +L  +  + + + +K   + ++L+  
Sbjct: 1598 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA 1657

Query: 2009 LEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAAL 2068
             +   F+      + WL   E  LAS D+G  + SV  L+K+H+  E   ++  +R   L
Sbjct: 1658 NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1717



 Score =  417 bits (1073), Expect = e-116
 Identities = 406/1854 (21%), Positives = 795/1854 (42%), Gaps = 140/1854 (7%)

Query: 313  DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
            DL +W+ +   ++N+ + A+ + G +  L               + KG ++    + +S 
Sbjct: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420

Query: 373  MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430
              +    +   H     SD  R  E L      R   L    +R+++ EQ    + F R 
Sbjct: 421  DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475

Query: 431  AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
                + W+S+ +  +  ++ G  L +VEA  KKHE  E   +A EE++ AL++ A +L +
Sbjct: 476  TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535

Query: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
             N++  + +  R+D +L   + L E    RR +L  +  LQ+ F+D      W++E K  
Sbjct: 536  NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594

Query: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
              + E  K    ++  +QKH+  EA+++    ++ A+  A  K  +   Y   +   +  
Sbjct: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651

Query: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
            R++ +   +++L      +  +L ++ +  +F   +++ E W+ E E   +S DYGKDLT
Sbjct: 652  RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711

Query: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
            +V  LQ+KH   E ++      ++ I  +A        F    I+ + + + A+++ LK+
Sbjct: 712  NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771

Query: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
                 K+ L D+    Q   D +D + W+++   + +  + G+D    + L KKH+    
Sbjct: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831

Query: 791  ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
            E+      ++ + Q+     EE    + DV  +L  L + ++ + A+A  R+Q L+++L 
Sbjct: 832  EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891

Query: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
                F + +  E WM EKE  +   +     +  E +  + + L  ++    + I  +  
Sbjct: 892  AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951

Query: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
             A S  +   P   E  +                       +  L +++Y    E++ + 
Sbjct: 952  QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985

Query: 970  ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018
            +T K     T +  + KD  +    D  G +  A  +KL     D A   +R + LE + 
Sbjct: 986  VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040

Query: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
                 Q+ +D+     ++ G    R K +EEL+  L +  + ++ +L +  +     ++ 
Sbjct: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100

Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127
            ++ Q W++  + A+ SE++   L + E L ++    + ++  ++   + + +  E +   
Sbjct: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160

Query: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155
                  +Q     E   +  R                          ++ L+  W +L +
Sbjct: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220

Query: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215
            + E RS  L      Q F +DA + +  +  +   L        L + +A  RK E F  
Sbjct: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280

Query: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275
             +    DKV S  ++  +L+      ++ ++EK   +        ++A +    L D+ +
Sbjct: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340

Query: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
            LQ FL + ++L  WIN  + L S D    +         +HQ    E+ +  G  +  + 
Sbjct: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
             G+QL+      +  + QKL+ L +   +L+    ++   L       L  +       W
Sbjct: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460

Query: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
            ++A E  L ++D G  L SV  ++ K +  +  +NV++E++  L A    +   G  A  
Sbjct: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520

Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507
             I  R  ++L+   R K Q+   R+KL       Q SRD+++   W+ E+L  A    Y 
Sbjct: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580

Query: 1508 --TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGHLQ 1563
              TN+Q+     +K+Q  + E+  +  R+  V+  G  L+E       +  ++ RL  L 
Sbjct: 1581 DPTNIQSKH---QKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALA 1637

Query: 1564 SSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVML 1623
              W  L + +A + Q+L++AN+ Q +     + + W+ E E  + S++  KD      +L
Sbjct: 1638 DQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLL 1697

Query: 1624 KRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERK 1683
            K+H   +  +  +   +K L S+A  L+++   +  Q+   +  ++  +  +K +A  R+
Sbjct: 1698 KKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRR 1757

Query: 1684 RKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
             KL   + L Q  R+ DD E WI EK+L+  S + G+D   V  LR K +    E  A  
Sbjct: 1758 AKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA-H 1816

Query: 1744 QERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYF 1803
            +  +  V    ++L D        I +      E W +L +L   R Q L  S +  ++ 
Sbjct: 1817 EPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFV 1876

Query: 1804 YTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRL 1862
                E    I+EK   +  ED G   +  +   + H AFE +     V   +  DV T  
Sbjct: 1877 ANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCTNG 1933

Query: 1863 QTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
            Q          E I +K + ++     L  A A R+ +L + +   +F   A  + SW+ 
Sbjct: 1934 QDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIG 1993

Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQASEE 1979
                 ++T +  RD+SSV+ L+   +  +A ++  + +  +    L + LL  +H  S+ 
Sbjct: 1994 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKA 2053

Query: 1980 IREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQEPY 2031
            I  +   +M R  ++     AR ++L       R + ++   F++ AS   +W    E  
Sbjct: 2054 IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED 2113

Query: 2032 LASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
            L      ++++ ++ L + H+AF  S +S    F  L +    ++K  ++A  P
Sbjct: 2114 LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2166



 Score =  280 bits (715), Expect = 1e-74
 Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)

Query: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
            SG KV++   D     + +R + +   ++    +   R   L     FQ FQ+DA++ E 
Sbjct: 4    SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58

Query: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
             +  ++  +A  E        +  ++K + F   ++ N   ++   ++GN +++EG+  S
Sbjct: 59   WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300
            + I+ ++  +  +     EK +E  + L    +L  +L+ C+++  WINDK  ++TS+++
Sbjct: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177

Query: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360
              D   ++     K + F  ++A+HE  +  ++    +L+ E+     L+  K + ++  
Sbjct: 178  GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236

Query: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420
            W  L+    ++   L  A       +   +   WI   E  + SDD G+DL SV  +L K
Sbjct: 237  WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296

Query: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473
             + +E  +   ++++  L A+   + +    +   I+ +  +L+            R  +
Sbjct: 297  HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356

Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
            L  S    +   D  D T WV E   L  + +  +++   +  + ++Q  + EI  H   
Sbjct: 357  LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416

Query: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
             +   + GQ L+ A      ++ E+L  L      L E    R Q+     + Q +Y D 
Sbjct: 417  FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476

Query: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653
            ++ + W+ +QE +++++++    +    +LK+H   ++++      I  L   A  L+  
Sbjct: 477  EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536

Query: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713
             H   E +   +  +      L + A  R+ +L + +HL Q  R++D+L+ W++EK   A
Sbjct: 537  NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596

Query: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773
            +  E  +D  ++     K + F  E  A  Q R+D +    ++LID  H     +A   +
Sbjct: 597  TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654

Query: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832
             +  +W  LLE  + +   L  +    ++     +I L L + +     +D G D +  +
Sbjct: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714

Query: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884
            +  + H   E ++         + +Q +QFQD         AG   AE I+ K++ + A 
Sbjct: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765

Query: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944
            ++AL +    R+ +L D+    + F    D  +W+        +  R +D+  V+ L+K 
Sbjct: 766  YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825

Query: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000
            HQ + AEI        A  + G ++++  H A+E+++ KL        E+N+KWEA    
Sbjct: 826  HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878

Query: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057
               R + L   L+  Q+  DA+ AE+W+  +EP + S D+G   DS E L+K+HEA    
Sbjct: 879  ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938

Query: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095
             +++     AL          R+ A+   ++  P ++E
Sbjct: 939  LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966



 Score =  219 bits (557), Expect = 3e-56
 Identities = 195/860 (22%), Positives = 366/860 (42%), Gaps = 68/860 (7%)

Query: 411  RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETD 470
            R++L   + L+Q +R  D      E W+SE  +  + +++  D   +++  +KH+A E +
Sbjct: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYK-DPTNIQSKHQKHQAFEAE 1598

Query: 471  TAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
              A  +R+R + D+   L +       +  + AR   +   W +L +    + Q+L+   
Sbjct: 1599 LHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1658

Query: 529  ALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAIT 588
              Q     +     W+ E++A L S ++GK L  V +LL+KH+L+EADI+   D++K + 
Sbjct: 1659 KQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLN 1718

Query: 589  AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDE 648
            +          +   D   ++D+   +   F+++ +MAA R+A+L +S RL +FF +MD+
Sbjct: 1719 SQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDD 1775

Query: 649  AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
             ESWIKEK+ +  S DYG+DLT V  L++KHK  E EL   +  ++ +      +     
Sbjct: 1776 EESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT 1835

Query: 709  FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
             G  +I+ R+ +    W +LK LAA   + L+++  + QF  + ++ +AW+ +   L++ 
Sbjct: 1836 IGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVAS 1895

Query: 769  EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALR 827
            ED G    A + L KKH+ F  +    +  +  +    Q    +      +++ +++ L 
Sbjct: 1896 EDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLN 1955

Query: 828  ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQ 887
                 +   A  R+ +L E         + D  E W+GEKE  L   +    L  ++ + 
Sbjct: 1956 GKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLL 2015

Query: 888  HRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSER 946
             + +  D  ++    + I  +    + L+ + H +S+ ++     L  RW       + R
Sbjct: 2016 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2075

Query: 947  REAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIAIQRK 996
            ++ +   L   ++    E+       K     S      +DL        L  I A++  
Sbjct: 2076 KKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2132

Query: 997  LSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ-------S 1049
                   +++ QA  + L    +Q+               + LEE W+ LQ+        
Sbjct: 2133 HDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELE 2192

Query: 1050 LQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQHAGIK 1107
            LQ ++    E  +L Q F Q  + F  W+  T+  +     M E     E  L+      
Sbjct: 2193 LQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH 2252

Query: 1108 DEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWESRSH 1162
             EI   +   +++++ G  +       E L+L  +       GL   W+ L ++     H
Sbjct: 2253 QEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2306

Query: 1163 TLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
             L Q                   + F+ F KD       L++QE+          L   E
Sbjct: 2307 NLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDLPMVE 2363

Query: 1205 AG--IRKFEDFLGSMENNRD 1222
             G    +FE  L +++ NRD
Sbjct: 2364 EGEPDPEFEAILDTVDPNRD 2383



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)

Query: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
            A   K++ +   H  + E +   ++  AS   +W E     L      NSL  ++   +A
Sbjct: 2073 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2132

Query: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
               +R+     +  +   L  L   I+S   A+N     P+    +  +   W +L++  
Sbjct: 2133 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2186

Query: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458
              REL L+ E  RQE+ ++L + F + A     W+ E +  +       +  G   + +E
Sbjct: 2187 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2246

Query: 459  AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
            A K+KH+ I     A   +++ +EDL   +E+    D K        + + W  L +L  
Sbjct: 2247 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2302

Query: 519  SRRQRLE 525
              +  LE
Sbjct: 2303 RMQHNLE 2309



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)

Query: 316  TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373
            +WI +    L +  +   L+ VQ  L    T+    +   FQ++G  N+  L   + +  
Sbjct: 1990 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2047

Query: 374  RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433
               ++ +   H     + + + W  L      R+  L        K+E L   F +KA+ 
Sbjct: 2048 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2102

Query: 434  RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
              +W    +  +        L  ++A ++ H+A  +  ++ +     L +L ++++    
Sbjct: 2103 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2162

Query: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545
                      + +   W  LQ++++ R   L+     Q    KL Q+     +    W+ 
Sbjct: 2163 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2222

Query: 546  EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
            E + +LL       E G    ++E   +KH+ + A +  Q  K++ + AA       +  
Sbjct: 2223 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2275

Query: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
               D +  +     L Q +++L  +    +  LEQ  +        +EA   +KE   ++
Sbjct: 2276 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2332

Query: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696
               D  KD +  L     H+ F+  LR L   L  +
Sbjct: 2333 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2362


>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
            isoform 1 [Homo sapiens]
          Length = 2477

 Score =  568 bits (1463), Expect = e-161
 Identities = 450/1737 (25%), Positives = 806/1737 (46%), Gaps = 151/1737 (8%)

Query: 355  KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414
            K Q+    E  L   QSR+ A  +       G+ + D+N   +    A     ++L  +L
Sbjct: 610  KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663

Query: 415  IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
            +   +L+ +  R       F+R     E WL E +  +A D++G DL  V+  +KKH  +
Sbjct: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723

Query: 468  ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527
            E D AA+++R+  +   A++ +   + D + I  +++ ++  +  L+E + +R+Q+L  +
Sbjct: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783

Query: 528  LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587
            L LQ+LF+D+     W+ E +    S   GK L+ V++LL+KH+ ++A+IA    ++KA+
Sbjct: 784  LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843

Query: 588  TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647
            T       E   +   D   ++ ++  L Q +E L   A+ R+  LE S +  ++F + +
Sbjct: 844  TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900

Query: 648  EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707
            EAESW++EKE I  S DYGKD  S   L +KH+A   +L    + ++ + ++A     R+
Sbjct: 901  EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958

Query: 708  QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761
            Q      E   + V A +D Q K       K      L ++ N   ++ + +D + ++  
Sbjct: 959  QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018

Query: 762  AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821
            A+               + L        E L E +G +   ++Q        +++  V+ 
Sbjct: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064

Query: 822  RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881
            R++ + ELY  ++   + R+  L+++   + +F E +  + W+ EKE  L   E+   LE
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124

Query: 882  DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931
             +EV+Q +FD   +++K   +++  +N  A  L ES    + EV+  Q            
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183

Query: 932  ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
                                       LN RW++ Q L  ER + + SA  V  +  D +
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243

Query: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024
            ET +WI +K + + +T + G DLA + A+QRK  G ERD+AA+  +V++L   +++L+ S
Sbjct: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302

Query: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084
            HPE  ED+ ++   L + W  L +    ++  LG+   LQ FL D  D  +W++  +  V
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362

Query: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142
            +S+++ + +  AE LL++H   + EID    ++Q  ++ G++++       PE   + Q+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419

Query: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202
            L+ LD     L + W  R   L QCL  Q F +D +QAE  ++ +E  L   +  DSL++
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479

Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
             EA I+K EDF  ++    +K+ +     ++L+A G+     I  +   + DR R+   +
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539

Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH-----NKWLKHQA 1317
              E    L ++  LQ F ++  E+  WI++KL T+ D SY +  N+      +K  KHQA
Sbjct: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599

Query: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHL 1375
            F AEL ++   +  +   G  L++      +   V  +L AL   W  L   + EK+Q L
Sbjct: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659

Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEEL 1435
              A           D + W+S +E  L S+D GKDL SVN +L K + +E  ++  ++ L
Sbjct: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719

Query: 1436 GELFAQVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLE 1488
             +L +Q  S+            D   +I  RF  +      R+ +L  S    Q  RD++
Sbjct: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779

Query: 1489 DETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA 1548
            DE  W++E+  L  S DYG +L  VQ   KK++ L+ E+  H P ++ VL  G++L +  
Sbjct: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839

Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI 1608
             I  +++++RL      W  L++ AA R QRL ++ E QQ+  + +E EAWI E+   V 
Sbjct: 1840 TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVA 1899

Query: 1609 SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQV 1668
            S++          +LK+H   +     +   +  + +  Q L+   +   E I      +
Sbjct: 1900 SEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL 1959

Query: 1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLL 1728
            +   + L+  A +RK KL+      Q   + D +E WI EKE    + + G+D   V  L
Sbjct: 1960 NGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTL 2019

Query: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788
              K   F     A  QE + N+ A  ++L+ A H ++  I      L + W+ LL     
Sbjct: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079

Query: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLL 1848
            R + L                  L  + H    ED+ L      +F +  +AF       
Sbjct: 2080 RKKKL------------------LEAQSHFRKVEDLFL------TFAKKASAFN------ 2109

Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
                  F++    L         E I+   +E   A+++ L +      QL +   + + 
Sbjct: 2110 ----SWFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2164

Query: 1909 FSMARDLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA--- 1950
            F +A +  +W            ++ II++ E +   E+ R   + +L  ++ Q  NA   
Sbjct: 2165 FRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQ 2224

Query: 1951 -EIETRSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
               ETR+     +C+      L+ Q +A++   ++++ + S+ K++ +   A  E L
Sbjct: 2225 WIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2281



 Score =  519 bits (1337), Expect = e-146
 Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)

Query: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
            I+ R ++V  ++ + K+L+   ++ L+D+  F  FQ DA++L+ W+Q+  ++ S E+   
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72

Query: 774  DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830
             +  T   GK  KH+ F  E++ + G +  L++       E    S  +  RL  L   +
Sbjct: 73   -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
            + ++ +   +  +L +A  L     E +    W+ +KE  +   E+   LE +EV+Q +F
Sbjct: 132  ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191

Query: 891  DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
            +    +M     +++ VN  A  L++  HP    +K  QD +N  WQ  + L  +R+  +
Sbjct: 192  EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251

Query: 951  DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
              A  V  +  D +ET  WI +K +++ S  D GRDLA + A+ RK  GLERD+AA++ +
Sbjct: 252  FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310

Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
            V AL  E+ +L  SHP     I  +++ L   W+ ++     +   L +  +LQ FL D 
Sbjct: 311  VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370

Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
             D  +W++  +  + ++++   +  AE LL +H   K EID H+DS++   ESG+ ++  
Sbjct: 371  RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430

Query: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
                +D     + ++L  L     AL  +WE R     QC+  Q F +D +Q +  +S Q
Sbjct: 431  GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486

Query: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
            E  L + +  DSL++ EA ++K EDF  S+    +K+ +  +   KL+   +   + +  
Sbjct: 487  EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546

Query: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
            +   +  R    +E+A      L D+  LQ F ++  EL  W+N+K+ T+ D +Y +  N
Sbjct: 547  RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606

Query: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367
            L  K  KHQAF AEL++++  ++ ++  G++L+D        V+ ++  +  LW +L   
Sbjct: 607  LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666

Query: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427
            T+ K   L  A       +   D+  W+  +E  L SDD GKDLT+V  +  K   +E  
Sbjct: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726

Query: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480
            V   ++ +  +  Q     + G     +I+K       R+  L EP+  RK++L  S   
Sbjct: 727  VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786

Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
             Q+ RD+EDE  W+ E+ P+A S + G +L  VQ  +KK+Q LQ EI GH PR++ V Q+
Sbjct: 787  QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846

Query: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
            G  +VE      +D++ +L  L   W+ L+  A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 847  GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906

Query: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
             E+E  V S +  KDE+ A  +LK+H      +  YG +I+ L  +AQ          +Q
Sbjct: 907  REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959

Query: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709
            +     +  K     L D  E+  R+          L N  +    K E +D + ++   
Sbjct: 960  VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019

Query: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769
             +    P   Q      LL ++       + A+ QE++DN     +        EA +++
Sbjct: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063

Query: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828
                 + E++  LLEL + R  +L  S      F    E+   I+EK   L  E+VG D 
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123

Query: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878
               E   +    F+++L     +++    VA  L++     E+ +A+Q +E         
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183

Query: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912
                                     +E++  W++L    A  R+QL+ +A +  RF   A
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242

Query: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972
             +   W+E   + + T     D++SV+ L + H+G   ++       ++  E  E L+Q 
Sbjct: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302

Query: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032
              +++E+++EK  ++      + ++ + R  +L    ++ +F  D     +W+      +
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362

Query: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
            +S +    V   E L++RH+       + A  F A E+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400



 Score =  474 bits (1220), Expect = e-133
 Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)

Query: 608  IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
            IQ+R   +   +     ++  R+ +LE S R   F  + +E E WI+EK QI S  +Y K
Sbjct: 15   IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73

Query: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
            D T++    +KH+AFE E++     + ++ +  + M++   F    I  R+ E+  QW+ 
Sbjct: 74   DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133

Query: 728  LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
            L +        L  A+   Q+  + +D+  W+ D   +++ E++GQD      L KK ++
Sbjct: 134  LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193

Query: 788  FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846
            F  ++      +  + Q A    +E     ++    Q  +   +Q++   A  RQ +L  
Sbjct: 194  FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253

Query: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
            A ++     + D    W+ EKE+ +A  +    L  ++ +  + + L++++  L  ++  
Sbjct: 254  AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313

Query: 907  VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
            +   A+ L +S    + +++  ++ L T W+  +TL +ER   ++ + R+  +  D  + 
Sbjct: 314  LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373

Query: 967  SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
            + W+T+  K + +  +L  D+AG  A+  +    + ++ A +    + +   Q L+ +  
Sbjct: 374  TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432

Query: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
               +++ ++   L E    L +  + +     +   LQ F +D +    W+S  +  + +
Sbjct: 433  YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492

Query: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144
            ED+ +SL   E LL++H   +  +   ++    + E   K+IQ      Y +  +  R +
Sbjct: 493  EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549

Query: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202
             L +  NAL      R   LA     Q+F +D+ + ++ ++ +  T      + P +L+ 
Sbjct: 550  ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609

Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
                ++K + F   +  N+ ++ +   +G KL+   +   D++  ++  +    +K  E 
Sbjct: 610  K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666

Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320
             +   + LR+  + Q F +N +++ LW+ +    L S D   D   N+ N   KH    A
Sbjct: 667  TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725

Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
            ++A+H+  ++ I  + +Q  D        + +K EAL   ++ L+     + Q L+ +  
Sbjct: 726  DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785

Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
                 +   D   WI   E    S + GKDL  V  +L K + ++ ++   +  +  +  
Sbjct: 786  LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845

Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493
            +  +M EEG  A   ++ +  +L +          +R++ LE S    Q   D  +   W
Sbjct: 846  KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905

Query: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549
            + E+ P+  S DYG +  + +  +KK++ L +++  +   ++ + ++ Q    Q+    +
Sbjct: 906  MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965

Query: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608
               ++L   L   Q    R      G +  L ++     + ++ ++ + ++    +  + 
Sbjct: 966  ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025

Query: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663
                 S E   +E+G+I +      +Q  +++  R  K+  S +              +R
Sbjct: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065

Query: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723
            ++ QV++ Y  L ++ E+RK  LE     F L RE ++L+QWI+EKE   +S E+G D +
Sbjct: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124

Query: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762
             V +L+ KF DF ++  A  + R+ ++N   E L   G                      
Sbjct: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183

Query: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807
            +++ T + WK                 LNE W  L +L + R QLL +++++ R+     
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243

Query: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866
            E    I+EK++ L  D  G D ++ ++  R H  FER+L  LG +V    + A RL  ++
Sbjct: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303

Query: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926
              E AE +Q K  E++ AW +L      R+ +L D+ D  RF S  RDL+SW+  I   +
Sbjct: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362

Query: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986
             + E  +DV+  E L++ HQ    EI+ R+  F A  + G+ LL   H AS EI++KL  
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422

Query: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
            +   R ++ + W  R   L   LE+  F RD   AE W+ A+E +L + D G ++DSVE 
Sbjct: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482

Query: 2047 LIKRHEAFEKSTASWAERFAALE 2069
            LIK+HE F+K+     E+ AAL+
Sbjct: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505



 Score =  470 bits (1210), Expect = e-132
 Identities = 405/1855 (21%), Positives = 811/1855 (43%), Gaps = 128/1855 (6%)

Query: 274  YHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFAN- 332
            YH F ++  L  +           +E     + +   A +L  WI++ + + +   + + 
Sbjct: 26   YHRFKELSTLRRQ----------KLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP 75

Query: 333  -SLTGVQQQLQAFSTYRTVEKPP--KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
             +L G  Q+ QAF            K  E GNL +      S     ++ + T      +
Sbjct: 76   TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI------SEGHFASETIRTR-----L 124

Query: 390  SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
             +++R WE L   E  RE  ++  L++ +KL Q  R  +        W+++ + +V  + 
Sbjct: 125  MELHRQWELL--LEKMREKGIK--LLQAQKLVQYLRECEDVM----DWINDKEAIVTSEE 176

Query: 450  FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
             G DL  VE  +KK E  +TD AA+EERV  +   A +L +E + +++ I  ++D +   
Sbjct: 177  LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236

Query: 510  WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
            W  L+ L   R+ +L     +Q+  +D+  +I W+ E +  + S +FG+ L  V+ LL+K
Sbjct: 237  WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296

Query: 570  HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
            H+ +E D+A   DKVKA+ A   +  +     P     IQ +   L   +E++  +AA R
Sbjct: 297  HEGLERDLAALEDKVKALCAEADRLQQS---HPLSATQIQVKREELITNWEQIRTLAAER 353

Query: 630  KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
             A+L  S RL +F  +  +  SW+ E + + ++ +   D+     L  +H+  + E+   
Sbjct: 354  HARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAH 413

Query: 690  DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
            +   +   +    ++A   +   ++  ++  +S +   L +L    ++  +   +   F 
Sbjct: 414  EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFY 473

Query: 750  GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
             D + +  W+      L  ED+G    +  AL KKH+DF + L      +  L++ A   
Sbjct: 474  RDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKL 533

Query: 810  PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
             +    +  DV  R  AL      +  +A  R+ +L ++  L   F ++D  + W+ EK 
Sbjct: 534  IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKM 593

Query: 869  KWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQY 928
            K   +    D   +L+    +    + E+    ++ID +  A   L++  H    EV   
Sbjct: 594  KTATDEAYKDP-SNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652

Query: 929  QDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLA 988
             + + + W+        +   +  A +   +  + E+   W+ +    + S  D G+DL 
Sbjct: 653  MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLT 711

Query: 989  GIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
             +  +Q+K + LE DVAA Q R+D +  +++Q  D+     E+I ++Q+ L   ++ L++
Sbjct: 712  NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771

Query: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
             +  ++  L +  +LQ   +D++D + W+   +   AS +  + L   + LL++H  ++ 
Sbjct: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831

Query: 1109 EIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
            EI GH+   + V + G  +++ G    E +    +L  L+  W AL      R   L   
Sbjct: 832  EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQRRQDLEDS 889

Query: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
            L  Q++  DA +AE+ +  +E  +   +     ++AEA ++K E  +          LS 
Sbjct: 890  LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD--------LSA 941

Query: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELT 1287
              S  + + E    +   +++V   +D      E  +E  + L D  E     ++ +E+T
Sbjct: 942  YGSSIQALRE---QAQSCRQQVAPTDD------ETGKELVLALYDYQE-----KSPREVT 987

Query: 1288 LWIND--KLLTSQDVSYDEARNLHNKWLKHQAFVAEL-----ASHEGWLENID--AEGKQ 1338
            +   D   LL S +  + +      +     A+V +L     AS E  LE     A  ++
Sbjct: 988  MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQE 1047

Query: 1339 LMDEKPQFT---ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWI 1395
             +D + + T     VS +++ +  L+  L    +++   L  +    +  +   +L +WI
Sbjct: 1048 QIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWI 1107

Query: 1396 SAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDAD-- 1453
            +  E  L S++ G DL  V  +  K    +  +   +  L ++      +  EG  A+  
Sbjct: 1108 NEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEV 1167

Query: 1454 -----------------------------------------LSIEKRFLDLLEPLGRRKK 1472
                                                       + +R+  L +    R +
Sbjct: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227

Query: 1473 QLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTP 1532
             L S+    +  RD ++   W+EE+     + +YG +L +VQ   +K++  + ++     
Sbjct: 1228 LLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD 1287

Query: 1533 RVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
            +V  + +  ++L+++     +DL+E+   L  +W  L + A  R  +L D+++ Q++  D
Sbjct: 1288 KVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSD 1347

Query: 1593 ADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652
              +  +WI      V SDE+ KD  GA  +L+RH   +  ++      +      Q LL+
Sbjct: 1348 FRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA 1407

Query: 1653 AGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELV 1712
             GH    +I +    +D+  A L+    +R+  L+    L    R+ +  E W++ +E  
Sbjct: 1408 HGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467

Query: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWK 1772
             ++ + G   D V  L  K  DF +    + +E++  + AF ++LI AGH     I+  +
Sbjct: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526

Query: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE 1832
            + + + W  L   +  +   L  S  L ++     EI   I EK +   ++   D +  +
Sbjct: 1527 NEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ 1586

Query: 1833 -----SFHRVHTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAW 1885
                 S H+ H AFE ELH    +++   D+   L  + A AG + +A++ +   ++  W
Sbjct: 1587 LSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQW 1645

Query: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYH 1945
            Q L+   A +  +L +   +  F +  +D   W+  +   + +++  +D++SV  L+K H
Sbjct: 1646 QFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKH 1705

Query: 1946 QGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
            Q + A+I              +SL+      + ++++K   +  R +++     +R  +L
Sbjct: 1706 QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKL 1765

Query: 2006 RMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
                 + QF RD    E+W+  ++  + S D+G  +  V+ L K+H+  E   A+
Sbjct: 1766 NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820



 Score =  463 bits (1191), Expect = e-130
 Identities = 383/1744 (21%), Positives = 783/1744 (44%), Gaps = 103/1744 (5%)

Query: 397  ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447
            E+ E+ + RR+  L           +R++KLE   R   F R A   E W+ E  ++ + 
Sbjct: 10   ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69

Query: 448  DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507
            +N+  D   ++   +KH+A E +  A    +  L++    +  E +   + I  R   + 
Sbjct: 70   ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128

Query: 508  RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567
            R W  L E ++ +  +L     L +  ++    +DW+++ +A + S E G+ L  VE L 
Sbjct: 129  RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188

Query: 568  QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627
            +K +  + D+A   ++V  +     K  +    Q  + ++I+ +   +   ++ L  +A 
Sbjct: 189  KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245

Query: 628  GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687
             R+ +L  +  + +F  ++DE  SWIKEKEQ+ +S D+G+DL SV  L RKH+  E +L 
Sbjct: 246  QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305

Query: 688  GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747
             L+  ++ +  EA  +         QI+ + +E+   W+Q++ LAA     L D+    +
Sbjct: 306  ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365

Query: 748  FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
            F  D  DL +W+ +   L++ +++  D     AL  +H++   E++      +  ++  Q
Sbjct: 366  FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425

Query: 808  G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
                     S +V  +L  L E    ++   +LR+Q+ ++ +DL   + +T+  + WM +
Sbjct: 426  ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485

Query: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
            +E +L   ++ D+L+ +E +  + +  ++ +     +I  ++  A  L+++ H    +V 
Sbjct: 486  QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545

Query: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
              +D L +R  A       RR  +  +  +  +  D +E   W+ +K K   +T +  +D
Sbjct: 546  TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603

Query: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
             + +    +K    E +++A Q+R+DALE+  Q+L+D +   K+++  R   +  LW+ L
Sbjct: 604  PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663

Query: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
             ++ + +   L E +Q Q F ++++D + WL   +  +AS+D  + L   + L ++HA +
Sbjct: 664  LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723

Query: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            + ++  HQD    +  ++ +    G  D E   + ++ E L   + AL     +R   LA
Sbjct: 724  EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
              L  Q+  +D +  E  +  +E   A       L   +  ++K +     +  +  ++ 
Sbjct: 782  DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841

Query: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
            +    GN +V EG+  ++ +K K+  +  +      KA +    L D+L+ Q +  +  E
Sbjct: 842  AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901

Query: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343
               W+ +K  ++ S D   DE  +      KH+A +++L+++     +I A  +Q    +
Sbjct: 902  AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957

Query: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401
             Q      +   E +  L+D  + + +E T      +   L L    + + W   + D+ 
Sbjct: 958  QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013

Query: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
                   ++  DP +  +  N     L   +  + +R+E++         + +E G   L
Sbjct: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064

Query: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511
                +E+ +  LLE   +RK  LE S  K  + R+  +   W+ E+     S + G +L+
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124

Query: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560
             V++  KK    Q ++  +  R++D+ +  + L    + A E+     +E  G       
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184

Query: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
                                      L   W  L++ A  R Q L  A+E Q+++ DADE
Sbjct: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
             + WI E+   + +D    D      + ++H   +R +   G  +  L   A+ L+ + H
Sbjct: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303

Query: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714
            PE  E +     ++++ ++ L   A++RK KL + + L +   +  DL  WI+    + S
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363

Query: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771
            S E+ +D      L ++ ++   E  A    R     AF    ++L+  GH  +  I + 
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419

Query: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830
             D L++  ADL +    R  +L    +L  +     +    +  +   L  ED G    +
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479

Query: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
             E+  + H  F++ +++   ++   Q  A +L  A    K + I ++  EV   W+ L  
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538

Query: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI--ETQERPRDVSSVELLMKY--HQ 1946
                +R++L ++    +F     ++ +W+   ++    E+ + P ++   +LL K+  HQ
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598

Query: 1947 GINAEIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWER 2004
               AE+   +      +++G SL++R   A  E  ++ +L  +  + + + +K   + ++
Sbjct: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658

Query: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
            L+   +   F+      + WL   E  LAS D+G  + SV  L+K+H+  E   ++  +R
Sbjct: 1659 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718

Query: 2065 FAAL 2068
               L
Sbjct: 1719 LKDL 1722



 Score =  420 bits (1080), Expect = e-117
 Identities = 408/1856 (21%), Positives = 796/1856 (42%), Gaps = 139/1856 (7%)

Query: 313  DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
            DL +W+ +   ++N+ + A+ + G +  L               + KG ++    + +S 
Sbjct: 372  DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420

Query: 373  MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430
              +    +   H     SD  R  E L      R   L    +R+++ EQ    + F R 
Sbjct: 421  DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475

Query: 431  AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
                + W+S+ +  +  ++ G  L +VEA  KKHE  E   +A EE++ AL++ A +L +
Sbjct: 476  TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535

Query: 491  ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
             N++  + +  R+D +L   + L E    RR +L  +  LQ+ F+D      W++E K  
Sbjct: 536  NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594

Query: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
              + E  K    ++  +QKH+  EA+++    ++ A+  A  K  +   Y   +   +  
Sbjct: 595  TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651

Query: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
            R++ +   +++L      +  +L ++ +  +F   +++ E W+ E E   +S DYGKDLT
Sbjct: 652  RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711

Query: 671  SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
            +V  LQ+KH   E ++      ++ I  +A        F    I+ + + + A+++ LK+
Sbjct: 712  NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771

Query: 731  LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
                 K+ L D+    Q   D +D + W+++   + +  + G+D    + L KKH+    
Sbjct: 772  PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831

Query: 791  ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
            E+      ++ + Q+     EE    + DV  +L  L + ++ + A+A  R+Q L+++L 
Sbjct: 832  EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891

Query: 850  LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
                F + +  E WM EKE  +   +     +  E +  + + L  ++    + I  +  
Sbjct: 892  AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951

Query: 910  AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
             A S  +   P   E  +                       +  L +++Y    E++ + 
Sbjct: 952  QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985

Query: 970  ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018
            +T K     T +  + KD  +    D  G +  A  +KL     D A   +R + LE + 
Sbjct: 986  VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040

Query: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
                 Q+ +D+     ++ G    R K +EEL+  L +  + ++ +L +  +     ++ 
Sbjct: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100

Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127
            ++ Q W++  + A+ SE++   L + E L ++    + ++  ++   + + +  E +   
Sbjct: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160

Query: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155
                  +Q     E   +  R                          ++ L+  W +L +
Sbjct: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220

Query: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215
            + E RS  L      Q F +DA + +  +  +   L        L + +A  RK E F  
Sbjct: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280

Query: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275
             +    DKV S  ++  +L+      ++ ++EK   +        ++A +    L D+ +
Sbjct: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340

Query: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
            LQ FL + ++L  WIN  + L S D    +         +HQ    E+ +  G  +  + 
Sbjct: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
             G+QL+      +  + QKL+ L +   +L+    ++   L       L  +       W
Sbjct: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460

Query: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
            ++A E  L ++D G  L SV  ++ K +  +  +NV++E++  L A    +   G  A  
Sbjct: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520

Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507
             I  R  ++L+   R K Q+   R+KL       Q SRD+++   W+ E+L  A    Y 
Sbjct: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580

Query: 1508 --TNLQTVQLFMK--KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGH 1561
              TN+Q  +L  K  K+Q  + E+  +  R+  V+  G  L+E       +  ++ RL  
Sbjct: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640

Query: 1562 LQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIV 1621
            L   W  L + +A + Q+L++AN+ Q +     + + W+ E E  + S++  KD      
Sbjct: 1641 LADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNN 1700

Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE 1681
            +LK+H   +  +  +   +K L S+A  L+++   +  Q+   +  ++  +  +K +A  
Sbjct: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760

Query: 1682 RKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA 1741
            R+ KL   + L Q  R+ DD E WI EK+L+  S + G+D   V  LR K +    E  A
Sbjct: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              +  +  V    ++L D        I +      E W +L +L   R Q L  S +  +
Sbjct: 1821 -HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQ 1879

Query: 1802 YFYTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
            +     E    I+EK   +  ED G   +  +   + H AFE +     V   +  DV T
Sbjct: 1880 FVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCT 1936

Query: 1861 RLQTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSW 1918
              Q          E I +K + ++     L  A A R+ +L + +   +F   A  + SW
Sbjct: 1937 NGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESW 1996

Query: 1919 MESIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQAS 1977
            +      ++T +  RD+SSV+ L+   +  +A ++  + +  +    L + LL  +H  S
Sbjct: 1997 IGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQS 2056

Query: 1978 EEIREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQE 2029
            + I  +   +M R  ++     AR ++L       R + ++   F++ AS   +W    E
Sbjct: 2057 KAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAE 2116

Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
              L      ++++ ++ L + H+AF  S +S    F  L +    ++K  ++A  P
Sbjct: 2117 EDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2171



 Score =  280 bits (715), Expect = 1e-74
 Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)

Query: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
            SG KV++   D     + +R + +   ++    +   R   L     FQ FQ+DA++ E 
Sbjct: 4    SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58

Query: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
             +  ++  +A  E        +  ++K + F   ++ N   ++   ++GN +++EG+  S
Sbjct: 59   WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300
            + I+ ++  +  +     EK +E  + L    +L  +L+ C+++  WINDK  ++TS+++
Sbjct: 118  ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177

Query: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360
              D   ++     K + F  ++A+HE  +  ++    +L+ E+     L+  K + ++  
Sbjct: 178  GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236

Query: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420
            W  L+    ++   L  A       +   +   WI   E  + SDD G+DL SV  +L K
Sbjct: 237  WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296

Query: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473
             + +E  +   ++++  L A+   + +    +   I+ +  +L+            R  +
Sbjct: 297  HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356

Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
            L  S    +   D  D T WV E   L  + +  +++   +  + ++Q  + EI  H   
Sbjct: 357  LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416

Query: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
             +   + GQ L+ A      ++ E+L  L      L E    R Q+     + Q +Y D 
Sbjct: 417  FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476

Query: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653
            ++ + W+ +QE +++++++    +    +LK+H   ++++      I  L   A  L+  
Sbjct: 477  EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536

Query: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713
             H   E +   +  +      L + A  R+ +L + +HL Q  R++D+L+ W++EK   A
Sbjct: 537  NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596

Query: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773
            +  E  +D  ++     K + F  E  A  Q R+D +    ++LID  H     +A   +
Sbjct: 597  TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654

Query: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832
             +  +W  LLE  + +   L  +    ++     +I L L + +     +D G D +  +
Sbjct: 655  EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714

Query: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884
            +  + H   E ++         + +Q +QFQD         AG   AE I+ K++ + A 
Sbjct: 715  NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765

Query: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944
            ++AL +    R+ +L D+    + F    D  +W+        +  R +D+  V+ L+K 
Sbjct: 766  YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825

Query: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000
            HQ + AEI        A  + G ++++  H A+E+++ KL        E+N+KWEA    
Sbjct: 826  HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878

Query: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057
               R + L   L+  Q+  DA+ AE+W+  +EP + S D+G   DS E L+K+HEA    
Sbjct: 879  ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938

Query: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095
             +++     AL          R+ A+   ++  P ++E
Sbjct: 939  LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966



 Score =  216 bits (551), Expect = 1e-55
 Identities = 195/864 (22%), Positives = 366/864 (42%), Gaps = 71/864 (8%)

Query: 411  RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF----GYDLAAVEAAKKKHEA 466
            R++L   + L+Q +R  D      E W+SE  +  + +++       L+ + +  +KH+A
Sbjct: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599

Query: 467  IETDTAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRL 524
             E +  A  +R+R + D+   L +       +  + AR   +   W +L +    + Q+L
Sbjct: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659

Query: 525  ETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKV 584
            +     Q     +     W+ E++A L S ++GK L  V +LL+KH+L+EADI+   D++
Sbjct: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719

Query: 585  KAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFW 644
            K + +          +   D   ++D+   +   F+++ +MAA R+A+L +S RL +FF 
Sbjct: 1720 KDLNSQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1776

Query: 645  EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
            +MD+ ESWIKEK+ +  S DYG+DLT V  L++KHK  E EL   +  ++ +      + 
Sbjct: 1777 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1836

Query: 705  ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHR 764
                 G  +I+ R+ +    W +LK LAA   + L+++  + QF  + ++ +AW+ +   
Sbjct: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896

Query: 765  LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRL 823
            L++ ED G    A + L KKH+ F  +    +  +  +    Q    +      +++ ++
Sbjct: 1897 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1956

Query: 824  QALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDL 883
            + L      +   A  R+ +L E         + D  E W+GEKE  L   +    L  +
Sbjct: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2016

Query: 884  EVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942
            + +  + +  D  ++    + I  +    + L+ + H +S+ ++     L  RW      
Sbjct: 2017 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2076

Query: 943  VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIA 992
             + R++ +   L   ++    E+       K     S      +DL        L  I A
Sbjct: 2077 SAARKKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133

Query: 993  IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ---- 1048
            ++         +++ QA  + L    +Q+               + LEE W+ LQ+    
Sbjct: 2134 LREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193

Query: 1049 ---SLQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQH 1103
                LQ ++    E  +L Q F Q  + F  W+  T+  +     M E     E  L+  
Sbjct: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT 2253

Query: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWE 1158
                 EI   +   +++++ G  +       E L+L  +       GL   W+ L ++  
Sbjct: 2254 KRKHQEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307

Query: 1159 SRSHTLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
               H L Q                   + F+ F KD       L++QE+          L
Sbjct: 2308 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDL 2364

Query: 1201 EAAEAG--IRKFEDFLGSMENNRD 1222
               E G    +FE  L +++ NRD
Sbjct: 2365 PMVEEGEPDPEFEAILDTVDPNRD 2388



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)

Query: 284  AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
            A   K++ +   H  + E +   ++  AS   +W E     L      NSL  ++   +A
Sbjct: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137

Query: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
               +R+     +  +   L  L   I+S   A+N     P+    +  +   W +L++  
Sbjct: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2191

Query: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458
              REL L+ E  RQE+ ++L + F + A     W+ E +  +       +  G   + +E
Sbjct: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251

Query: 459  AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
            A K+KH+ I     A   +++ +EDL   +E+    D K        + + W  L +L  
Sbjct: 2252 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307

Query: 519  SRRQRLE 525
              +  LE
Sbjct: 2308 RMQHNLE 2314



 Score = 45.1 bits (105), Expect = 8e-04
 Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)

Query: 316  TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373
            +WI +    L +  +   L+ VQ  L    T+    +   FQ++G  N+  L   + +  
Sbjct: 1995 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2052

Query: 374  RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433
               ++ +   H     + + + W  L      R+  L        K+E L   F +KA+ 
Sbjct: 2053 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107

Query: 434  RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
              +W    +  +        L  ++A ++ H+A  +  ++ +     L +L ++++    
Sbjct: 2108 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2167

Query: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545
                      + +   W  LQ++++ R   L+     Q    KL Q+     +    W+ 
Sbjct: 2168 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2227

Query: 546  EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
            E + +LL       E G    ++E   +KH+ + A +  Q  K++ + AA       +  
Sbjct: 2228 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2280

Query: 601  QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
               D +  +     L Q +++L  +    +  LEQ  +        +EA   +KE   ++
Sbjct: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2337

Query: 661  SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696
               D  KD +  L     H+ F+  LR L   L  +
Sbjct: 2338 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2367


>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
          Length = 2419

 Score =  513 bits (1321), Expect = e-145
 Identities = 384/1449 (26%), Positives = 674/1449 (46%), Gaps = 109/1449 (7%)

Query: 713  QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
            +I+ R +EV  ++   K+  A   + L+D+ +   F+ DADDL  W+ +   +L+ +   
Sbjct: 23   EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY- 81

Query: 773  QDEGATRALGK--KHKDFLEELEESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALREL 829
              E  T   GK  KH+    E++    +M  LE+ + + F        +    ++ LR L
Sbjct: 82   --EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139

Query: 830  YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHR 889
            +  ++     +  +L  AL       E      W+G+KE     +E+ +  E  EV+  +
Sbjct: 140  WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199

Query: 890  FDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREA 949
            F+    E+     ++  VN  AN   E  HP    ++  Q+ +N  W+  + L  +R++A
Sbjct: 200  FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259

Query: 950  VDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
            + +A  +  +  D  E  +WI +K  V+ S +D G+DL     +     GLER++A +  
Sbjct: 260  LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318

Query: 1010 RVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQD 1069
            +V  L  ++++L  SHP     I + ++ L   W+ ++     + + L        F  D
Sbjct: 319  KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378

Query: 1070 LDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ 1129
             D+   W++    A+ ++++P  +   E LL +H   K EID + D +Q   E+G+ ++ 
Sbjct: 379  FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438

Query: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189
               +    +  +++E LD  W AL  +W+ R     QCL F  F +D++Q ++ +S QE 
Sbjct: 439  ANHEASDEVR-EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497

Query: 1190 TLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
             L + +  +SL +AEA ++K EDF  +     +K+++   +  KL+ + +  S+ IK   
Sbjct: 498  FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557

Query: 1250 QLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH 1309
              +  R     EKA     LL+++L LQ   ++  +L  WIN K   + D  Y + +NL 
Sbjct: 558  DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617

Query: 1310 NKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTK 1369
            ++  K Q F  ELA ++  LENI   G+++++     +  V+ +L  +  LW+EL   TK
Sbjct: 618  SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677

Query: 1370 EKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV 1428
            +K   L  A +  L+ + +A DL +W+  +E Q+ S+D GK L  V   L K   +E  V
Sbjct: 678  QKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736

Query: 1429 NVRKEELGELFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLGRRKKQLESSRAK 1480
              R++++ ++   + +  EE G  D         S+  RF  L EPL  RKK+L      
Sbjct: 737  AARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795

Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
              I RD EDE  W++E  P A S   G +L   +  + +++ +   I  H PR++++ +R
Sbjct: 796  QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855

Query: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRL----------QRLRDANEAQ--- 1587
            G ++VE      +D+  R+  L  + + LR  AA R           Q L D +EA+   
Sbjct: 856  GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915

Query: 1588 ----------QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYG 1637
                       Y  D + A A + + E +++      D   A+       +QQ+A    G
Sbjct: 916  REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEG 975

Query: 1638 ------------------RNI-------------------KQLASRAQGLLSAGH----- 1655
                              R +                   K  A+  QG++ A +     
Sbjct: 976  VAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035

Query: 1656 ------------PEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLE 1703
                         E   I + Q Q++  Y  L D AEER+R+L   Y+ F L  E  D+ 
Sbjct: 1036 HDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDML 1095

Query: 1704 QWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG-- 1761
            +WI EK+    +   G + D V  L+ KF +F ++     + R+ ++N   + L+  G  
Sbjct: 1096 EWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDLLFEGLL 1150

Query: 1762 HSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP 1821
              E A I   +  LN  W  L  L D + QLL +++ +  +     +    I++K + L 
Sbjct: 1151 TPEGAQI---RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS 1207

Query: 1822 E-DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQE 1880
              D G D  + ++  R H  FER+L  LG +V    + A RL  ++  +  E +Q ++ E
Sbjct: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKME 1266

Query: 1881 VSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVEL 1940
            ++ AW+ L      R+  L +    + F S ARDL +W+ SI   + +QE   D++ +E+
Sbjct: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326

Query: 1941 LMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA 2000
            L++ HQ   A++E  +  F A  +    L+   H AS EI +KLQ V   R ++ + WE 
Sbjct: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386

Query: 2001 RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
            R + L   LE+  F  +    E+W++A+E  L S D   ++DS+E L+K+ +  +K+  +
Sbjct: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITA 1445

Query: 2061 WAERFAALE 2069
               +   LE
Sbjct: 1446 QEGKITDLE 1454



 Score =  471 bits (1211), Expect = e-132
 Identities = 357/1423 (25%), Positives = 669/1423 (47%), Gaps = 71/1423 (4%)

Query: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
            +S++   WE L EA  ++   L       E  +QL  +F+  A   + WL + +  V  +
Sbjct: 662  LSEVASLWEELLEATKQKGTQLH------EANQQL--QFENNAEDLQRWLEDVEWQVTSE 713

Query: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
            ++G  LA V+   +KH  +E+  AA +++V  L DLA   E+  + D K I AR+++++ 
Sbjct: 714  DYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773

Query: 509  LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
             +  L+E L +R+++L   L LQ + +D      W+ E +    S   GK L+  + LL 
Sbjct: 774  RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
            +H+++  +IA    +++ IT    K  E   +   D   +  R+  L Q  E L   AA 
Sbjct: 834  RHRVILENIASHEPRIQEITERGNKMVEEGHFAAED---VASRVKSLNQNMESLRARAAR 890

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
            R+  LE + +  ++  ++ EAE+WI+EKE I  + +YG D  +   L +KH+AF  +L  
Sbjct: 891  RQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNS 950

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
                ++ +  +A+           Q  A ++ V+ +               Q     + F
Sbjct: 951  FGDSMKALRNQANAC-------QQQQAAPVEGVAGE---------------QRVMALYDF 988

Query: 749  QGDAD-DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
            Q  +  ++     D   LLS   + +D     A    H+  +  +   R   +       
Sbjct: 989  QARSPREVTMKKGDVLTLLSS--INKDWWKVEAAD--HQGIVPAVYVRRLAHDEFPM--- 1041

Query: 808  GFPEEFRDSP-DVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
              P+  R+ P ++T R + +   Y+ ++ +A+ R++RL +  + + +  E      W+ E
Sbjct: 1042 -LPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQE 1100

Query: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG--HPRSRE 924
            K+     +E+ D  E    +Q +FD   +++ T   ++  +N  A+ L+  G   P   +
Sbjct: 1101 KKAENTGVELDDVWE----LQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ 1156

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
            ++Q    LN+RW + Q L  E+R+ + SA  V  +  + ++T + I  K + + S  D G
Sbjct: 1157 IRQ---ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQAL-SAADPG 1212

Query: 985  RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
             DL  + A+QR+  G ERD+  +  +V  L   +++L +SHP+  ED+ +++  L E W+
Sbjct: 1213 SDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWE 1272

Query: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
             LQ   + +++ L E  +   FL    D Q W+S     V+S+++ E L   E LL++H 
Sbjct: 1273 DLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ 1332

Query: 1105 GIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162
              + +++    ++Q +++   ++I       PE   + ++L+ +    + L + WE R  
Sbjct: 1333 EHRADMEAEAPTFQALEDFSAELIDSGHHASPE---IEKKLQAVKLERDDLEKAWEKRKK 1389

Query: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222
             L QCL  Q FQ +  Q E+ +  +E +L   +   SL++ EA ++K +D   ++     
Sbjct: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEG 1448

Query: 1223 KVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQN 1282
            K+         L+A+ +   ++I  ++Q + DR +    +  +    L D   L+ F ++
Sbjct: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508

Query: 1283 CQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE 1342
             +EL  WI++ L T+ D SY +A N+  K+LKHQ F  E+      +  +   G  L++ 
Sbjct: 1509 LEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568

Query: 1343 KP--QFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
                     + ++LE L   WD L   T +K + L+ A        +  D   W+S  E 
Sbjct: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628

Query: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE---ELGELFAQVPSMGEEGGDADL--- 1454
             L   D  +DL S   +L K + +E ++  R++   +L  L   + S G    D  +   
Sbjct: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688

Query: 1455 -SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTV 1513
             ++ KRFL++ E      ++L+ + A  Q  +DL+DE  W+EE+L    S DYG +LQ V
Sbjct: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748

Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAA 1573
            Q  +KK++ L+ E++ H P +++VL   ++L + A +  ++++ RL      W++L+E A
Sbjct: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808

Query: 1574 AGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAV 1633
              R  +L ++ E  Q+  +A+E EAWI E+    +  +          +L +H   +   
Sbjct: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868

Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDVAEERKRKLENMY 1690
              +   ++ + ++ + +L+    E  Q   +  +++   +    L       K +LE+ Y
Sbjct: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY 1928

Query: 1691 HLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNV 1750
               +   + D +E WI++KE    +   G D      L  K         +  QER+  +
Sbjct: 1929 AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988

Query: 1751 NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
                ++LI A H+++  I E    L + W  LLE      Q L
Sbjct: 1989 TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031



 Score =  367 bits (942), Expect = e-101
 Identities = 373/1695 (22%), Positives = 735/1695 (43%), Gaps = 90/1695 (5%)

Query: 390  SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
            +++N AWE L     +R+ AL N    Q        RF R       W+ E + ++  ++
Sbjct: 240  NEVNAAWERLRGLALQRQKALSNAANLQ--------RFKRDVTEAIQWIKEKEPVLTSED 291

Query: 450  FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
            +G DL A E     H+ +E + A   ++V+ L   A++L   +  D  +I   K++++  
Sbjct: 292  YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351

Query: 510  WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
            W +++ L  SR ++L+ T    +   D      WM+E  A + + E    +   E LL +
Sbjct: 352  WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411

Query: 570  HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
            H+  + +I    D+ ++             ++  D   +++++  L+  +  L  +   R
Sbjct: 412  HQQHKHEIDSYDDRFQSADETGQDLVNAN-HEASDE--VREKMEILDNNWTALLELWDER 468

Query: 630  KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
              Q EQ      F+ + ++ +SW+  +E    + D G  L S   L +KH+ FE+     
Sbjct: 469  HRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQ 528

Query: 690  DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
            +  +  + + A  ++    +    I+A    + A+ D L++ AA  ++ L+++    +  
Sbjct: 529  EEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLY 588

Query: 750  GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
             D+DDLK W+    +L   ED  +D    ++  +K + F +EL  ++  +E++++  Q  
Sbjct: 589  EDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEM 647

Query: 810  PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
             E    + D VT RL  +  L+++++     +  +L EA        E +A +L     +
Sbjct: 648  IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF--ENNAEDL-----Q 700

Query: 869  KWLAEMEMPDTLED----LEVVQHRF---DILDQEMKTLMTQIDGVNLAANSLVESGHPR 921
            +WL ++E   T ED    L  VQ+R     +L+  +     Q+D +   A    E GHP 
Sbjct: 701  RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760

Query: 922  SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
            S++++  Q+ L  R++A +  ++ R++ +   L +   C D E+   WI +      ST 
Sbjct: 761  SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820

Query: 982  DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEE 1041
             LG+DL     +  +   +  ++A+ + R+  +     ++++      ED+  R K L +
Sbjct: 821  -LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879

Query: 1042 LWQGLQ-QSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLL 1100
              + L+ ++ + Q DL   V Q Q +L DL + + W+   +  V + +       A  LL
Sbjct: 880  NMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALL 938

Query: 1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESR 1160
            ++H     +++   DS + ++       Q Q  P   + G++                  
Sbjct: 939  KKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQ------------------ 980

Query: 1161 SHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
                 + +   +FQ  + +   +      TL      D  +   A  +     +      
Sbjct: 981  -----RVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035

Query: 1221 RDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFL 1280
             D+   P+    +    GN     I ++ + IE+++R   ++A+E    L          
Sbjct: 1036 HDEF--PMLPQRRREEPGN-----ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA 1088

Query: 1281 QNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM 1340
                ++  WI +K   +  V  D+   L  K+     F  +L ++E  L +I+     L+
Sbjct: 1089 YEAGDMLEWIQEKKAENTGVELDDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLL 1145

Query: 1341 DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
             E    T   +Q  + L+  W  LQ    E+ Q L +A + ++  +   D  + I     
Sbjct: 1146 FEG-LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ 1204

Query: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRF 1460
             L + DPG DL SV  +  + +  E  +    +++  L      + E   DA   ++++ 
Sbjct: 1205 ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264

Query: 1461 LDLLEPL----GRRKKQLESSRAK------LQISRDLEDETLWVEERLPLAQSADYGTNL 1510
            ++L E      GR K + ES          L  +RDL++   W+     +  S +   +L
Sbjct: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQN---WISSIGGMVSSQELAEDL 1321

Query: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570
              +++ ++++Q  + ++    P  + +     +L+++      ++E++L  ++   D L 
Sbjct: 1322 TGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLE 1381

Query: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
            +A   R + L    E Q +  + D+ E+W+  +E  + SD+    +    +M KR    +
Sbjct: 1382 KAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK 1441

Query: 1631 RAVEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENM 1689
                  G+ I  L   A+ L++  H   E+I  RLQ  +D+ +  LK    + + KL + 
Sbjct: 1442 AITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVLDR-WKALKAQLIDERTKLGDY 1499

Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
             +L Q  R+ ++LE+WISE  L  +  E  +D  ++     K + FA E      E+V  
Sbjct: 1500 ANLKQFYRDLEELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDG-RSEQVHG 1557

Query: 1750 V----NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYT 1805
            V    N+ IE     G+ EA  + E  + L E W  LLE  + + + L  +    R+  +
Sbjct: 1558 VINLGNSLIECSACDGNEEA--MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615

Query: 1806 GAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT 1864
              +    + E    L  +D   D ++A +  + H   ERE+      ++    +A  L +
Sbjct: 1616 IRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS 1675

Query: 1865 AYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIR 1924
            +      + I  K+  V+  +  + +  A    +L +    F+FF    D  SW+E  + 
Sbjct: 1676 S-GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLI 1734

Query: 1925 QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKL 1984
            ++ +Q+  RD+  V+ L+K H+ +  E+          L++ E L  +     EEI+ +L
Sbjct: 1735 RVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRL 1794

Query: 1985 QQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSV 2044
             Q +   +++ E  +AR  +L   LE  QF ++A   EAW+  +      GD G T+ + 
Sbjct: 1795 AQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAAT 1854

Query: 2045 EKLIKRHEAFEKSTA 2059
            + L+ +HEA E   A
Sbjct: 1855 QSLLMKHEALENDFA 1869



 Score =  362 bits (929), Expect = 2e-99
 Identities = 341/1698 (20%), Positives = 712/1698 (41%), Gaps = 72/1698 (4%)

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---------FDRKAAM 433
            P +  + S   +  E+ EE + RR+  L      +E++ +  ++         F R A  
Sbjct: 5    PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64

Query: 434  RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
               W+ E   ++   ++  D   ++   +KH+++E +       +  LE   +E     +
Sbjct: 65   LGKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123

Query: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
               +   A  + +  LW  L EL   +  +L   L  Q+  Q+    ++W+ + +A   S
Sbjct: 124  SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATS 183

Query: 554  AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
             E G+     E L +K +  + ++  +  +V  +     +  E     P D  +IQ + +
Sbjct: 184  VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEEN--HP-DLPLIQSKQN 240

Query: 614  HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
             +   +E L  +A  R+  L  +  L +F  ++ EA  WIKEKE + +S DYGKDL +  
Sbjct: 241  EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE 300

Query: 674  ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
             L   HK  E  L  +   ++++  +A  +        PQI+   +++ + W+ ++ LA 
Sbjct: 301  GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT 360

Query: 734  FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
               + LQ    + +F  D D+L  W+ +    ++ +++  D      L  +H+    E++
Sbjct: 361  SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID 420

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
                  +  ++  Q       ++ D V  +++ L   +  ++   D R ++ ++ LD + 
Sbjct: 421  SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL 480

Query: 853  VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
             + +++  + WM  +E +L   ++ ++L   E +  + +  ++       +I  V+  A 
Sbjct: 481  FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540

Query: 913  SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
             L+   H  S  +K  +D L  R  A +   + RR  +  +L +     D ++   WI  
Sbjct: 541  KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600

Query: 973  KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            K K+ +   +  +D+  + +  +K    E+++A  + +++ +++  Q++++      +++
Sbjct: 601  KKKLADD--EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNV 658

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPES 1092
              R   +  LW+ L ++ + +   L E +Q   F  + +D Q WL   +  V SED  + 
Sbjct: 659  TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG 718

Query: 1093 LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNA 1152
            L E +  L++H  ++  +   QD    + +      +    P+   +  R E L   + A
Sbjct: 719  LAEVQNRLRKHGLLESAVAARQDQVDILTDLA-AYFEEIGHPDSKDIRARQESLVCRFEA 777

Query: 1153 LGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFED 1212
            L     +R   L   L  Q   +D +  EA +   E +         L A++  + +   
Sbjct: 778  LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837

Query: 1213 FLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRD 1272
             L ++ ++  ++    + GNK+V EG+  ++ +  +V+ +         +A      L  
Sbjct: 838  ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897

Query: 1273 NLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENI 1332
            N++ Q +L +  E   WI +K     + +Y             +A  A L  HE +L ++
Sbjct: 898  NVQFQQYLADLHEAETWIREKEPIVDNTNYG---------ADEEAAGALLKKHEAFLLDL 948

Query: 1333 DAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLN 1392
            ++ G  +   + Q  A   Q+   +  +  E         Q + A      R        
Sbjct: 949  NSFGDSMKALRNQANACQQQQAAPVEGVAGE---------QRVMALYDFQAR-------- 991

Query: 1393 KWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ-----VNVRKEELGELFAQVPSMGE 1447
               S  E  ++  D    L+S+N+   K++  + Q     V VR+    E         E
Sbjct: 992  ---SPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE 1048

Query: 1448 EGGD---ADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
            E G+       IE ++  LL+    R+++L     +  ++ +  D   W++E+    ++ 
Sbjct: 1049 EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAE 1104

Query: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
            + G  L  V    KK    Q ++  + PR+ D+ +    L+    +  +  + R   L S
Sbjct: 1105 NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNS 1163

Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVML- 1623
             W  L+  A  + Q L  A+  + ++ +AD+ +  I E++   +S   P  +  ++  L 
Sbjct: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI-EKKCQALSAADPGSDLFSVQALQ 1222

Query: 1624 KRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-EQIIRLQGQVDKHYAGLKDVAEER 1682
            +RH   +R +   G  +  L   A+  LS  HP+  E + R + ++++ +  L+   ++R
Sbjct: 1223 RRHEGFERDLVPLGDKVTILGETAE-RLSESHPDATEDLQRQKMELNEAWEDLQGRTKDR 1281

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAI 1742
            K  L      +    +  DL+ WIS    + SS E+ +D   + +L ++ ++   +  A 
Sbjct: 1282 KESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA- 1340

Query: 1743 GQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRY 1802
                   +  F   LID+GH  +  I +    +     DL +  + R ++L    +L  +
Sbjct: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400

Query: 1803 FYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRL 1862
                 ++   +  +   L  D   D S+ +S   +    +     +  Q  +  D+    
Sbjct: 1401 QGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA 1457

Query: 1863 QTAYAGE--KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
            ++  A E    E I  + Q V   W+AL       RT+L D A+  +F+    +L  W+ 
Sbjct: 1458 ESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517

Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ--HQASE 1978
             ++      E  +D ++++     HQ    E++ RS+     + LG SL++        E
Sbjct: 1518 EML-PTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576

Query: 1979 EIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
             ++E+L+Q+      + E+   + ++L       +F+      E WL   E  LA  D  
Sbjct: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636

Query: 2039 HTVDSVEKLIKRHEAFEK 2056
              + S   L+K+H+  E+
Sbjct: 1637 RDLASAGNLLKKHQLLER 1654



 Score =  328 bits (842), Expect = 3e-89
 Identities = 370/1832 (20%), Positives = 733/1832 (40%), Gaps = 117/1832 (6%)

Query: 297  AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
            A+     ++++    ++ + WI++   VL S  +   L   +     F +++ +E+    
Sbjct: 259  ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEG---LFHSHKGLER---- 311

Query: 357  QEKGNLEVLLFTIQSRM-RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
                NL V+   ++    +A    +  P D   + ++    + +   E+ R LA      
Sbjct: 312  ----NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE--DLVSSWEHIRALATS---- 361

Query: 416  RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473
            R EKL+      RF         W++E    +  D    D+A  E    +H+  + +  +
Sbjct: 362  RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421

Query: 474  YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
            Y++R ++ ++  Q+L   N+     +  + + +   W+ L EL   R ++ E  L     
Sbjct: 422  YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481

Query: 534  FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593
            ++D      WM   +A L + + G  L   E LLQKH+  E     Q +K+  +     K
Sbjct: 482  YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541

Query: 594  FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653
                  Y   + + I+D +        E    AA R+  L++S  L K + + D+ ++WI
Sbjct: 542  LIGDDHYDSENIKAIRDGLLARRDALRE---KAATRRRLLKESLLLQKLYEDSDDLKNWI 598

Query: 654  KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713
             +K+++    DY KD+ ++    +K + FE EL      LE I +    M+    +    
Sbjct: 599  NKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN 657

Query: 714  IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
            +  R+ EV++ W++L +        L +A    QF+ +A+DL+ WL+D    ++ ED G+
Sbjct: 658  VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGK 717

Query: 774  DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE-EFRDSPDVTHRLQALRELYQQ 832
                 +   +KH      +   +  ++ L   A  F E    DS D+  R ++L   ++ 
Sbjct: 718  GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777

Query: 833  VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892
            +      R+++L + L L  +  +T+  E W+ E E       +   L   + + +R  +
Sbjct: 778  LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837

Query: 893  LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
            + + + +   +I  +    N +VE GH  + +V      LN   ++ +   + R+  +++
Sbjct: 838  ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897

Query: 953  ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
             ++   Y  D  E   WI +K  +V++T + G D     A+ +K      D+ +    + 
Sbjct: 898  NVQFQQYLADLHEAETWIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMK 956

Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD 1072
            AL  ++           E +   Q+ +  L+    +S +      G+V  L + +     
Sbjct: 957  ALRNQANACQQQQAAPVEGVAGEQRVMA-LYDFQARSPREVTMKKGDVLTLLSSIN---- 1011

Query: 1073 FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQT 1132
             + W  +                       H GI   +       +R+      ++  + 
Sbjct: 1012 -KDWWKVEAA-------------------DHQGIVPAV-----YVRRLAHDEFPMLPQRR 1046

Query: 1133 DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLA 1192
              E   + QR E ++  + +L    E R   L Q   + EF    +  + +   QE    
Sbjct: 1047 REEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ--RYNEFLLAYEAGDMLEWIQEKKAE 1104

Query: 1193 H--LEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
            +  +E  D  E      +KF++F   +  N  ++       + L+ EG L  +  + + +
Sbjct: 1105 NTGVELDDVWELQ----KKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160

Query: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNL 1308
            L   R       A E   LL     ++ F +   +    I  K   L++ D   D   ++
Sbjct: 1161 L-NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSD-LFSV 1218

Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATT 1368
                 +H+ F  +L      +  +    ++L +  P  T  + ++   L+  W++LQ  T
Sbjct: 1219 QALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRT 1278

Query: 1369 KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV 1428
            K++ + L+ A+   L L    DL  WIS++   + S +  +DLT +  +L + +     +
Sbjct: 1279 KDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADM 1338

Query: 1429 NVRKEELGELFAQVPSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKL 1481
                     L      + + G  A   IEK+         DL +   +RKK L+      
Sbjct: 1339 EAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ 1398

Query: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541
                + +    W+  R    +S D  ++L +++  MKK   L   I     ++ D+    
Sbjct: 1399 MFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA 1457

Query: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601
            + L+       +++  RL  +   W  L+        +L D    +Q+Y D +E E WI 
Sbjct: 1458 ESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517

Query: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-EQ 1660
            E  L    DE  KD         +H      V+     +  + +    L+     +G E+
Sbjct: 1518 EM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576

Query: 1661 IIRLQ-GQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMG 1719
             ++ Q  Q+ +H+  L +   ++ +KL       +      D E W+SE E + +  +  
Sbjct: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636

Query: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMW 1779
            +D      L  K +   RE  A  ++ + ++N   E L+ +G      I + KD +N+ +
Sbjct: 1637 RDLASAGNLLKKHQLLEREMLA-REDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF 1695

Query: 1780 ADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKH-RELPEDVGLDASTAESFHRVH 1838
             ++ EL     + L  +Y L ++F    +    I+EK  R   +D G D    ++  + H
Sbjct: 1696 LNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKH 1755

Query: 1839 TAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQ 1898
               E EL      +Q   D+A +L+   A    E IQ +  +    W+ L +    R  +
Sbjct: 1756 KRLEGELVAHEPAIQNVLDMAEKLKDK-AAVGQEEIQLRLAQFVEHWEKLKELAKARGLK 1814

Query: 1899 LVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI---ETR 1955
            L ++ +  +F   A +  +W+          +    +++ + L+  H+ +  +    ETR
Sbjct: 1815 LEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETR 1874

Query: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVC--- 2012
             +N  A                E+I  K+ Q  S+ KE++ K EA  E+   L +     
Sbjct: 1875 VQNVCA--------------QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920

Query: 2013 -----------QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
                       +F+  A V EAW+  +E  L +   G  +     L+ + +  + S  S+
Sbjct: 1921 KLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF 1980

Query: 2062 AERFAALEKPTTLELKERQIAERPAEETGPQE 2093
             +       P   +LK++ I+ +  +    +E
Sbjct: 1981 QQE----RLPEITDLKDKLISAQHNQSKAIEE 2008



 Score =  270 bits (689), Expect = 1e-71
 Identities = 197/857 (22%), Positives = 385/857 (44%), Gaps = 27/857 (3%)

Query: 1242 SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS 1301
            +++I+E+ Q +  R++   E+  E    L D+  LQ F ++  +L  WI +K+    D S
Sbjct: 21   AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80

Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLW 1361
            Y++  N+  K+ KHQ+  AE+ +    +  ++   ++               +E L  LW
Sbjct: 81   YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140

Query: 1362 DELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVN------ 1415
            D L   T EK   L  A      +Q  AD+ +WI   E    S + G+D           
Sbjct: 141  DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200

Query: 1416 -----RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470
                  ++AK  RV +      E   E    +P +  +  + + + E+     L  L  +
Sbjct: 201  EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWER-----LRGLALQ 255

Query: 1471 KKQLESSRAKLQ-ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            +++  S+ A LQ   RD+ +   W++E+ P+  S DYG +L   +     ++ L+  +  
Sbjct: 256  RQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAV 315

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQY 1589
             + +V+++  + ++L  +   D   ++E    L SSW+ +R  A  R ++L+      ++
Sbjct: 316  MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRF 375

Query: 1590 YLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQG 1649
              D DE   W+ E+   + +DE+P D  G  V+L RH + +  ++ Y    +      Q 
Sbjct: 376  SSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435

Query: 1650 LLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM--YHLFQLKRETDDLEQWIS 1707
            L++A H   +++      +D ++  L ++ +ER R+ E    +HLF   R+++ ++ W+S
Sbjct: 436  LVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY--RDSEQVDSWMS 493

Query: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
             +E    + ++G        L  K  DF  E     +E++  V+    +LI   H ++  
Sbjct: 494  RQEAFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSEN 552

Query: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLD 1827
            I   +DGL      L E   TR +LL  S  L + +    ++   I++K +   ++   D
Sbjct: 553  IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612

Query: 1828 ASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA--YAGEKAEAIQNKEQEVSAAW 1885
                +S  +    FE+EL +   Q++  Q     +     YA +    +  +  EV++ W
Sbjct: 613  IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN---VTTRLSEVASLW 669

Query: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYH 1945
            + LL+A   + TQL +   + +F + A DL  W+E +  Q+ +++  + ++ V+  ++ H
Sbjct: 670  EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729

Query: 1946 QGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
              + + +  R        +L     +  H  S++IR + + ++ R + + E    R ++L
Sbjct: 730  GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789

Query: 2006 RMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERF 2065
              LL +    RD    EAW+   EP   S   G  + + +KL+ RH    ++ AS   R 
Sbjct: 790  LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849

Query: 2066 AALEKPTTLELKERQIA 2082
              + +     ++E   A
Sbjct: 850  QEITERGNKMVEEGHFA 866



 Score =  244 bits (623), Expect = 7e-64
 Identities = 285/1461 (19%), Positives = 593/1461 (40%), Gaps = 94/1461 (6%)

Query: 306  KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
            ++   A DL  W+E     + S  +   L  VQ +L+      +     + Q        
Sbjct: 691  QFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQ-------- 742

Query: 366  LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI-RQEKLEQLA 424
               I + + A  +++  P D K   DI    ESL      R  AL+  L  R++KL  L 
Sbjct: 743  -VDILTDLAAYFEEIGHP-DSK---DIRARQESL----VCRFEALKEPLATRKKKLLDLL 793

Query: 425  --RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
              +   R     E W+ E +        G DL A +    +H  I  + A++E R++ + 
Sbjct: 794  HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853

Query: 483  DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
            +   ++ +E +   + + +R  ++ +    L+     R+  LE  +  Q+   D+  +  
Sbjct: 854  ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913

Query: 543  WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQP 602
            W+ E +  + +  +G        LL+KH+    D+   GD +KA+        + +   P
Sbjct: 914  WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA-AP 972

Query: 603  CDPQVIQDRISHLEQCFEELSNMAAGRKAQ-LEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
             +    + R+  L             +K   L     + K +W+++ A            
Sbjct: 973  VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA------------ 1020

Query: 662  SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
              D+   + +V + +  H  F          L Q  +E  G + ++Q          +++
Sbjct: 1021 --DHQGIVPAVYVRRLAHDEFP--------MLPQRRREEPGNITQRQ----------EQI 1060

Query: 722  SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
              Q+  L D A   ++ L    N F    +A D+  W+Q+       E+ G +      L
Sbjct: 1061 ENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWEL 1116

Query: 782  GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
             KK  +F ++L  +   +  + + A     E   +P+     Q L   +  +   AD ++
Sbjct: 1117 QKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQR 1176

Query: 842  QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
            Q L  A  +     E D  +  + +K + L+  +    L  ++ +Q R +  ++++  L 
Sbjct: 1177 QLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLG 1236

Query: 902  TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
             ++  +   A  L ES    + ++++ +  LN  W+  Q    +R+E+++ A + + +  
Sbjct: 1237 DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296

Query: 962  DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
               +   WI+    +V S+++L  DL GI  +  +      D+ A      ALE  S +L
Sbjct: 1297 KARDLQNWISSIGGMV-SSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL 1355

Query: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
            +DS      +I ++ + ++     L+++ + ++ +L +  +LQ F  + D  ++W+   +
Sbjct: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415

Query: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--L 1139
             ++ S+D   SL   E L+++   +   I   +     ++   E +I    D  Y    +
Sbjct: 1416 NSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLI---ADEHYAKEEI 1471

Query: 1140 GQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS 1199
              RL+ +   W AL          L      ++F +D ++ E  +S    T       D+
Sbjct: 1472 ATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDA 1531

Query: 1200 LEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLV----AEGNLYSDKIKEKVQLIEDR 1255
                   + K + F   ++   ++V   ++ GN L+     +GN   + +KE+++ +++ 
Sbjct: 1532 TNIQRKYL-KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGN--EEAMKEQLEQLKEH 1588

Query: 1256 HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWIN--DKLLTSQDVSYDEARNLHNKWL 1313
                 E+  +    L +    Q F  + ++   W++  + LL  +D + D A +  N   
Sbjct: 1589 WDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLA-SAGNLLK 1647

Query: 1314 KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ 1373
            KHQ    E+ + E  L++++   + L+         + +K + +++ +  +Q       +
Sbjct: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHE 1707

Query: 1374 HLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE 1433
             L  A +     Q   D   WI     ++ S D G+DL  V  +L K KR+E ++   + 
Sbjct: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEP 1767

Query: 1434 ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKK-------QLESSRAKLQISRD 1486
             +  +      + ++       I+ R    +E   + K+       +LE S   LQ  ++
Sbjct: 1768 AIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQN 1827

Query: 1487 LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVE 1546
             E+E  W+ E+  LA   D G  L   Q  + K++ L+N+   H  RV++V  +G+ ++ 
Sbjct: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN 1887

Query: 1547 AA---EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQ 1603
                 E   +++  ++  L      L +A A    +L D    Q++   AD  EAWI ++
Sbjct: 1888 KVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADK 1947

Query: 1604 ELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR-NIKQLASRAQGLLSAGHPEGEQII 1662
            E  + ++    D    + +L +      +++ + +  + ++      L+SA H + + I 
Sbjct: 1948 ETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIE 2007

Query: 1663 RLQGQVDKHYAGLKDVAEERKRK-------LENMYHLF-QLKRETDDLEQWISEKELVAS 1714
                 + K +  L + +   ++K       L+    LF +   +   L  W  + E   S
Sbjct: 2008 ERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLS 2067

Query: 1715 SPEMGQDFDHVTLLRDKFRDF 1735
             P      + +  L+    DF
Sbjct: 2068 EPVHCVSLNEIRQLQKDHEDF 2088



 Score =  241 bits (614), Expect = 7e-63
 Identities = 265/1344 (19%), Positives = 527/1344 (39%), Gaps = 106/1344 (7%)

Query: 810  PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEK 869
            P+    + ++  R Q +   YQ    +   R Q+L+++  L     + D    W+ EK  
Sbjct: 15   PKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVN 74

Query: 870  WLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQ 929
             L +    D   +++    +   L+ E++T    +  +          GH    E K + 
Sbjct: 75   ILTDKSYEDPT-NIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI 133

Query: 930  DHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAG 989
            + L   W     L  E+ + +  AL+   Y  +C +  +WI DK  +  S  +LG D   
Sbjct: 134  EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSV-ELGEDWER 192

Query: 990  IIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQS 1049
               + +K    + ++ A + RV  + + + +  + +      I  +Q  +   W+ L+  
Sbjct: 193  TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGL 252

Query: 1050 LQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDE 1109
               ++  L   + LQ F +D+ +   W+   +  + SED  + L  +E L   H G++  
Sbjct: 253  ALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERN 312

Query: 1110 IDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
            +    D  + +    EK+       +   + +  E L + W  +  +  SR   L     
Sbjct: 313  LAVMSDKVKELCAKAEKLTLSHPS-DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYW 371

Query: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
            +  F  D  +    ++ +   +   E P  +   E  + + +     +++  D+  S  +
Sbjct: 372  YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE 431

Query: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
            +G  LV   +  SD+++EK++++++      E   E        L+   F ++ +++  W
Sbjct: 432  TGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSW 491

Query: 1290 IN--DKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFT 1347
            ++  +  L ++D+  +   +      KH+ F     + E  +  +D    +L+ +    +
Sbjct: 492  MSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDS 550

Query: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDP 1407
              +    + L    D L+     + + L  +       +   DL  WI+  + +L  D+ 
Sbjct: 551  ENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADDED 609

Query: 1408 GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLD----- 1462
             KD+ ++   + K +  E ++ V K +L  +      M E G  A  ++  R  +     
Sbjct: 610  YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669

Query: 1463 --LLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKN 1520
              LLE   ++  QL  +  +LQ   + ED   W+E+      S DYG  L  VQ  ++K+
Sbjct: 670  EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729

Query: 1521 QTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL 1580
              L++ +     +V+ +        E    D +D+  R   L   ++ L+E  A R ++L
Sbjct: 730  GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789

Query: 1581 RDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNI 1640
             D    Q    D ++ EAWI E E    S  + KD   +  +L RH      +  +   I
Sbjct: 790  LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849

Query: 1641 KQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD 1700
            +++  R   ++  GH   E +      ++++   L+  A  R+  LE      Q   +  
Sbjct: 850  QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909

Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
            + E WI EKE +  +   G D +    L  K   F  +  + G    D++ A   +    
Sbjct: 910  EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFG----DSMKALRNQANAC 965

Query: 1761 GHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL 1820
               +AA +    +G+               Q + A YD                   RE+
Sbjct: 966  QQQQAAPV----EGV------------AGEQRVMALYDFQA-------------RSPREV 996

Query: 1821 PEDVG----LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQN 1876
                G    L +S  + + +V  A  + + +  V V++       +      E+   I  
Sbjct: 997  TMKKGDVLTLLSSINKDWWKVEAADHQGI-VPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055

Query: 1877 KEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVS 1936
            +++++   +++LLD    RR +L+   ++F     A D+L W+         QE+  + +
Sbjct: 1056 RQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI---------QEKKAENT 1106

Query: 1937 SVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK---LQQVMSRRKE 1993
             VEL   +      E++ +   F   L   E  L+  ++ ++++  +     +    R+E
Sbjct: 1107 GVELDDVW------ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160

Query: 1994 MNEKW---EARWERLRMLL----EVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
            +N +W   +   +  R LL     V  F R+A   +  +  +   L++ D G  + SV+ 
Sbjct: 1161 LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQA 1220

Query: 2047 LIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVSH 2106
            L +RHE FE+      ++   L                           GETA     SH
Sbjct: 1221 LQRRHEGFERDLVPLGDKVTIL---------------------------GETAERLSESH 1253

Query: 2107 HAATERTSPVSLWSRLSSSWESLQ 2130
              ATE      +   L+ +WE LQ
Sbjct: 1254 PDATEDLQRQKM--ELNEAWEDLQ 1275



 Score =  227 bits (578), Expect = 1e-58
 Identities = 262/1268 (20%), Positives = 522/1268 (41%), Gaps = 83/1268 (6%)

Query: 434  RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
            RE  + +   L    +   D   VEAA   H+ I    A Y  R+    D    L +   
Sbjct: 994  REVTMKKGDVLTLLSSINKDWWKVEAAD--HQGIVP--AVYVRRLA--HDEFPMLPQRRR 1047

Query: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
             +   IT R++ I   +  L +  + RR+RL        L  +    ++W+ E KA    
Sbjct: 1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE--- 1104

Query: 554  AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
               G  L +V +L +K    + D+     +++ I              P   Q+ Q+   
Sbjct: 1105 -NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE--- 1160

Query: 614  HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
             L   +  L  +A  ++  L  +  +  F  E D+ +  I++K Q  S+ D G DL SV 
Sbjct: 1161 -LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQ 1219

Query: 674  ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
             LQR+H+ FE +L  L   +  + + A  +          ++ +  E++  W+ L+    
Sbjct: 1220 ALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK 1279

Query: 734  FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
              K++L +A+ F+ F   A DL+ W+     ++S +++ +D      L ++H++   ++E
Sbjct: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339

Query: 794  ESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
                  + LE   A+        SP++  +LQA++     +    + R++ L + L+L  
Sbjct: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQM 1399

Query: 853  VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
              G  D  E WM  +E  L   +   +L+ LE +  + D LD+ +     +I  +   A 
Sbjct: 1400 FQGNCDQVESWMVARENSL-RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAE 1458

Query: 913  SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
            SL+   H    E+      +  RW+A +  + + R  +     +  +  D EE  +WI++
Sbjct: 1459 SLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE 1518

Query: 973  --KTKVVESTKDLGRDLAGIIAIQRKL---SGLERDVAAIQARVDALERESQQLMD--SH 1025
               T   ES KD          IQRK         +V     +V  +      L++  + 
Sbjct: 1519 MLPTACDESYKDATN-------IQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571

Query: 1026 PEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVA 1085
               +E + ++ + L+E W  L +    +   L E S+ Q F   + DF+ WLS  +  +A
Sbjct: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631

Query: 1086 SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEG 1145
             +D    L  A  LL++H  ++ E+   +D+ + +    E ++   T     ++ ++ + 
Sbjct: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIV-KKKDN 1690

Query: 1146 LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEA 1205
            ++  +  +  +  +    L +     +F +D    E+ +  +   ++  +    L+  + 
Sbjct: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQN 1750

Query: 1206 GIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQE 1265
             ++K +   G +  +   + + +D   KL  +  +  ++I+ ++    +   K  E A+ 
Sbjct: 1751 LLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKA 1810

Query: 1266 ASVLLRDNLELQNFLQNCQELTLWINDK-LLTSQDVSYDEARNLHNKWLKHQAFVAELAS 1324
              + L ++LE   F+QN +E   WIN+K  L  +    D      +  +KH+A   + A 
Sbjct: 1811 RGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870

Query: 1325 HEGWLENIDAEGKQLMDEKPQFTAL---VSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
            HE  ++N+ A+G+ ++++  Q  +    +S K+EAL+           EKT  L+ A ++
Sbjct: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN-----------EKTPSLAKAIAA 1919

Query: 1382 DLRLQTHAD------------LNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV- 1428
              +LQ   D            +  WI+  E  L+++  G DL     +LAK   ++  + 
Sbjct: 1920 -WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQ 1978

Query: 1429 NVRKEELGELFAQVPSMGEEGGDADLSIE-------KRFLDLLEPLGRRKKQLESSRAKL 1481
            + ++E L E+      +     +   +IE       KR+  LLE     +++L   +  L
Sbjct: 1979 SFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPL 2038

Query: 1482 QISRDLEDE--------TLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
            Q + DL  E          W E+         +  +L  ++   K ++     +      
Sbjct: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098

Query: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL--------RDANE 1585
             + +L+  QQ+              +  L+ +W  L +    R Q L        ++   
Sbjct: 2099 FKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158

Query: 1586 AQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLAS 1645
             Q++  +A     WI E   Y +   + K+       L+ + R+Q+ ++   R + ++  
Sbjct: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218

Query: 1646 RAQGLLSA 1653
                L  A
Sbjct: 2219 LGDNLEDA 2226



 Score =  208 bits (530), Expect = 4e-53
 Identities = 197/977 (20%), Positives = 422/977 (43%), Gaps = 56/977 (5%)

Query: 1120 VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK- 1178
            V+ SG KV++   +     + +R + + T + +       R   L      Q F++DA  
Sbjct: 10   VESSGPKVLETAEE-----IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64

Query: 1179 ------QAEAILSNQEYTLAHLEPPDSLE-------AAEAGIRKFEDFLGSMENNRDKVL 1225
                  +   IL+++ Y     E P +++       + EA ++     +  +E  R++  
Sbjct: 65   LGKWIMEKVNILTDKSY-----EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119

Query: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
            +    G+    E   + ++++    L+ +   +  ++   A       L+ Q ++Q C +
Sbjct: 120  T---MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRA-------LKFQQYVQECAD 169

Query: 1286 LTLWINDK--LLTSQDVSYDEARN--LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD 1341
            +  WI DK  + TS ++  D  R   LH K+   + F  EL + EG +  ++    +  +
Sbjct: 170  ILEWIGDKEAIATSVELGEDWERTEVLHKKF---EDFQVELVAKEGRVVEVNQYANECAE 226

Query: 1342 EKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ 1401
            E      L+  K   ++  W+ L+    ++ + LS A +     +   +  +WI   E  
Sbjct: 227  ENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPV 286

Query: 1402 LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFL 1461
            L S+D GKDL +   +    K +E  + V  +++ EL A+   +          I++   
Sbjct: 287  LTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE 346

Query: 1462 DLLEPLGRRKKQLESSRAKLQ-------ISRDLEDETLWVEERLPLAQSADYGTNLQTVQ 1514
            DL+      +    S   KLQ        S D ++ + W+ E+     + +  T++   +
Sbjct: 347  DLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406

Query: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
            + + ++Q  ++EI  +  R +   + GQ LV A      ++ E++  L ++W  L E   
Sbjct: 407  VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466

Query: 1575 GRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVE 1634
             R ++     +   +Y D+++ ++W+  QE ++ ++++      A  +L++H   + A  
Sbjct: 467  ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526

Query: 1635 DYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQ 1694
                 I  +   A  L+   H + E I  ++  +      L++ A  R+R L+    L +
Sbjct: 527  AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586

Query: 1695 LKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754
            L  ++DDL+ WI++K+ +A   +  +D  ++     K + F +E  A+ + +++N+    
Sbjct: 587  LYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTG 644

Query: 1755 ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTR-MQLLAASYDLHRYFYTGAEILG-- 1811
            + +I+ GH  +  +      +  +W +LLE    +  QL  A+  L   F   AE L   
Sbjct: 645  QEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ--FENNAEDLQRW 702

Query: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKA 1871
            L D + +   ED G   +  ++  R H   E  +     QV    D+A   +     +  
Sbjct: 703  LEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762

Query: 1872 EAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQER 1931
            + I+ +++ +   ++AL +  A R+ +L+D            D  +W++       +   
Sbjct: 763  D-IRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821

Query: 1932 PRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRR 1991
             +D+ + + L+  H+ I   I +         E G  +++  H A+E++  +++ +    
Sbjct: 822  GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881

Query: 1992 KEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRH 2051
            + +  +   R   L   ++  Q+  D   AE W+  +EP + + ++G   ++   L+K+H
Sbjct: 882  ESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKH 941

Query: 2052 EAFEKSTASWAERFAAL 2068
            EAF     S+ +   AL
Sbjct: 942  EAFLLDLNSFGDSMKAL 958



 Score =  171 bits (433), Expect = 7e-42
 Identities = 202/962 (20%), Positives = 402/962 (41%), Gaps = 74/962 (7%)

Query: 311  ASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT--VEKPPKFQEKGNLEVLLFT 368
            A DL  WI     +++S++ A  LTG++  L+    +R     + P FQ   +    L  
Sbjct: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL-- 1355

Query: 369  IQSRMRANNQKVYTPHDGKLV-SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRF 427
            I S   A+ +        KL   D+ +AWE             + + I  + LE   + F
Sbjct: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWE-------------KRKKILDQCLE--LQMF 1400

Query: 428  DRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE 487
                   E+W+   +  +  D+    L ++EA  KK + ++    A E ++  LE  A+ 
Sbjct: 1401 QGNCDQVESWMVARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459

Query: 488  LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEI 547
            L  + ++ ++ I  R   +L  W  L+  L   R +L     L++ ++D+    +W+ E+
Sbjct: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519

Query: 548  KAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCD--P 605
                    + K    ++    KH+    ++  + ++V  +        E      CD   
Sbjct: 1520 LPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE---CSACDGNE 1575

Query: 606  QVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDY 665
            + +++++  L++ ++ L      +  +L ++ R  +F   + + E W+ E E + +  D 
Sbjct: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQ 1635

Query: 666  GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQW 725
             +DL S   L +KH+  E E+   +  L+ +   A  +++   F   QI  +   V+ ++
Sbjct: 1636 ARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF 1695

Query: 726  DQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKH 785
              +++LAA   + L++A   FQF  D DD ++W+++    +S +D G+D    + L KKH
Sbjct: 1696 LNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKH 1755

Query: 786  KDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRL 844
            K    EL      ++++   A+   ++      ++  RL    E ++++   A  R  +L
Sbjct: 1756 KRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL 1815

Query: 845  QEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQI 904
            +E+L+        +  E W+ EK       +  DTL   + +  + + L+ +     T++
Sbjct: 1816 EESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRV 1875

Query: 905  DGVNLAANSL---VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV--DSALRVHNY 959
              V      +   V     +++E+    + LN +  +    ++  +  +  D A +  N+
Sbjct: 1876 QNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNW 1935

Query: 960  CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAI-QARVDALERES 1018
              D  E   WI DK   ++ T   G DL   + +  K   L+  + +  Q R+  +    
Sbjct: 1936 KADVVEA--WIADKETSLK-TNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1992

Query: 1019 QQLMDSHPEQKEDIGQRQKHLEELWQGL--------------QQSLQGQEDLLGEVSQLQ 1064
             +L+ +   Q + I +R   L + W+ L              Q  LQ  EDL  E +   
Sbjct: 1993 DKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKA 2052

Query: 1065 AFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESG 1124
            + L +      W    ++ ++      SL E  QL + H      +   Q  ++ + E  
Sbjct: 2053 SALNN------WCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106

Query: 1125 EKV-IQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL-----AQCLGF---QEFQK 1175
            +++   G     Y  L   +E L+  W  L  + E R   L      Q   F   QEF++
Sbjct: 2107 QQIKALGVPSSPYTWL--TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQ 2164

Query: 1176 DAKQ-AEAILSNQEYTL--AHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGN 1232
            +A    + IL  + Y L  + L+   +LE+     ++ +  + +M+    K+   VD G+
Sbjct: 2165 NASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKI---VDLGD 2221

Query: 1233 KL 1234
             L
Sbjct: 2222 NL 2223



 Score =  164 bits (414), Expect = 1e-39
 Identities = 204/1037 (19%), Positives = 417/1037 (40%), Gaps = 84/1037 (8%)

Query: 299  ETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQE 358
            E EK ++       DL    E+   +L+         G   Q++++   R  E   +  +
Sbjct: 1365 EIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVAR--ENSLRSDD 1422

Query: 359  KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEY--RRELALRNELI- 415
            K +L+ L   ++ R   +  K  T  +GK ++D+    ESL   E+  + E+A R + + 
Sbjct: 1423 KSSLDSLEALMKKR--DDLDKAITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVL 1479

Query: 416  ------------RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461
                         + KL   A  ++F R     E W+SE       +++  D   ++   
Sbjct: 1480 DRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYK-DATNIQRKY 1538

Query: 462  KKHEAIETDTAAYEERVRALEDLAQELEKENYHD--QKRITARKDNILRLWSYLQELLQS 519
             KH+    +     E+V  + +L   L + +  D  ++ +  + + +   W +L E    
Sbjct: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598

Query: 520  RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
            + ++L      Q+    +     W+ E +  L   +  + L    +LL+KH+L+E ++  
Sbjct: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658

Query: 580  QGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRL 639
            + D +K +            +     Q+++ +  ++ + F  +  +AA    +L+++  L
Sbjct: 1659 REDALKDLNTLAEDLLSSGTFNV--DQIVKKK-DNVNKRFLNVQELAAAHHEKLKEAYAL 1715

Query: 640  WKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQE 699
            ++FF ++D+ ESWI+EK    SS DYG+DL  V  L +KHK  E EL   +  ++ +   
Sbjct: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775

Query: 700  AHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWL 759
            A  +  +   G  +I+ R+ +    W++LK+LA      L+++  + QF  +A++ +AW+
Sbjct: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWI 1835

Query: 760  QDAHRLLSGEDVGQDEGATRALGKKHK----DFLEELEESRGVMEHLEQQAQGFPEEFRD 815
             + + L    D G    AT++L  KH+    DF       + V    E       +E   
Sbjct: 1836 NEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQ 1895

Query: 816  SPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEME 875
            + +++ +++AL E    +       + +L++         + D  E W+ +KE  L    
Sbjct: 1896 NKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNG 1955

Query: 876  MPDTLEDLEVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNT 934
                L D   +  + D LD  +++   + +  +    + L+ + H +S+ +++    L  
Sbjct: 1956 NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK 2015

Query: 935  RWQAFQTLVSERR------------------EAVDSALRVHNYCVDCEETSKWITDKTKV 976
            RW+      +  R                  E    A  ++N+C   EE    +++    
Sbjct: 2016 RWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEEN---LSEPVHC 2072

Query: 977  VESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL----MDSHPE---QK 1029
            V         L  I  +Q+        +A  QA    L    QQ+    + S P      
Sbjct: 2073 V--------SLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTV 2124

Query: 1030 EDIGQRQKHLEELWQGLQQSLQGQE-DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED 1088
            E + +  KHL ++ +  +Q LQ +E   +      Q F Q+   F  W+  T+       
Sbjct: 2125 EVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGS 2184

Query: 1089 MPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDT 1148
            + +     E  L+ +   + EI   +    ++ + G+ +     D   L +     GL  
Sbjct: 2185 LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL----EDALILDIKYSTIGLAQ 2240

Query: 1149 GWNALGRMWESRSHTLAQCLGFQEF----QKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
             W+ L ++     H L Q +  ++     ++  K+   I  + +  L          +  
Sbjct: 2241 QWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCL 2300

Query: 1205 AGIRKFEDFLGSMENNR--DKVLSPVDSGNKLVAEGNLYS----DKIKEKVQLIEDRHRK 1258
             G+  +   +   E+    +K L  VD G K       Y+    DK  E ++  ++    
Sbjct: 2301 RGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENA 2360

Query: 1259 NNEKAQEASVLLRDNLE 1275
                A+  S + +++++
Sbjct: 2361 FQALAEGKSYITKEDMK 2377



 Score =  149 bits (377), Expect = 2e-35
 Identities = 191/937 (20%), Positives = 367/937 (39%), Gaps = 66/937 (7%)

Query: 391  DINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF 450
            ++N AWE L+     R+ +L           Q    F  KA   + W+S    +V+    
Sbjct: 1266 ELNEAWEDLQGRTKDRKESLNEA--------QKFYLFLSKARDLQNWISSIGGMVSSQEL 1317

Query: 451  GYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLW 510
              DL  +E   ++H+    D  A     +ALED + EL    +H    I  +   +    
Sbjct: 1318 AEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLER 1377

Query: 511  SYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570
              L++  + R++ L+  L LQ +FQ     ++     + + L ++    L  +E L++K 
Sbjct: 1378 DDLEKAWEKRKKILDQCLELQ-MFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKR 1436

Query: 571  KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
              ++  I  Q  K+  +          + Y     + I  R+  +   ++ L       +
Sbjct: 1437 DDLDKAITAQEGKITDLEHFAESLIADEHYA---KEEIATRLQRVLDRWKALKAQLIDER 1493

Query: 631  AQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLD 690
             +L     L +F+ +++E E WI E         Y KD T++     KH+ F  E+ G  
Sbjct: 1494 TKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRS 1552

Query: 691  AHLEQIFQEAHGMV--ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
              +  +    + ++  +        ++ +++++   WD L +      K L +A    +F
Sbjct: 1553 EQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRF 1612

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
                 D + WL +A  LL+ +D  +D  +   L KKH+    E+      ++ L   A+ 
Sbjct: 1613 NTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAED 1672

Query: 809  FPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEK 867
                   + D +  +   + + +  V   A    ++L+EA  L+  F + D  E W+ EK
Sbjct: 1673 LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK 1732

Query: 868  EKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
               L  +   D   DL+ VQ+   +   L+ E+      I  V   A  L +       E
Sbjct: 1733 ---LIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE 1789

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
            ++         W+  + L   R   ++ +L    +  + EE   WI +K   +    D G
Sbjct: 1790 IQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK-NALAVRGDCG 1848

Query: 985  RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD---SHPEQKEDIGQRQKHLEE 1041
              LA   ++  K   LE D A  + RV  +  + + +++       Q ++I  + + L E
Sbjct: 1849 DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNE 1908

Query: 1042 LWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQ 1101
                L +++   +  L +    Q F    D  +AW++  + ++ +      L +   LL 
Sbjct: 1909 KTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLA 1968

Query: 1102 QHAGIKDEIDGHQDSYQR-----VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            +    +D +D    S+Q+     + +  +K+I  Q +        + + ++  + AL + 
Sbjct: 1969 K----QDTLDASLQSFQQERLPEITDLKDKLISAQHN--------QSKAIEERYAALLKR 2016

Query: 1157 WES--------RSHTLAQCLGFQE----FQKDAKQAEAILSNQEYTLAHLEPP---DSLE 1201
            WE         R   L + L  Q+    F + A +A A+ +  E    +L  P    SL 
Sbjct: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076

Query: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIE-------D 1254
                  +  EDFL S+   +      ++   ++ A G   S      V+++E       D
Sbjct: 2077 EIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSD 2136

Query: 1255 RHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLWI 1290
               +  ++ Q+       N E+ Q F QN      WI
Sbjct: 2137 IIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173


>gi|12025678 actinin, alpha 4 [Homo sapiens]
          Length = 911

 Score =  439 bits (1129), Expect = e-122
 Identities = 265/716 (37%), Positives = 397/716 (55%), Gaps = 36/716 (5%)

Query: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
           E  Q+KTFT W NSHL +   +I ++ +D RDG  L+ LLEV+SGE LPKP +GKMR+H 
Sbjct: 49  EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108

Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV------EE 162

Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
            SAK+ LLLWCQ KTA Y +VNV NF  SWKDGLAFNALIH+HRP+LI++DKL+  +   
Sbjct: 163 TSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222

Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
           NL +AF VAE+ L I  +LD ED+  T  PDEK+I+TYV +FYH FS  +       R+ 
Sbjct: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282

Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
           KV+    E E ++E Y  LASDLL WI +TI  L  R    ++  +QQ+L+ F  YR V 
Sbjct: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342

Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
           KPPK QEK  LE+   T+Q+++R +N+  + P +GK+VSDIN  W+ LE+AE   E  L 
Sbjct: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402

Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVA-QDNFGYDLAAVEAAKKKHEAIETD 470
           NE+ R E+L+ LA +F +KA++ E W    + ++  +D     L+ ++A  +KHEA E+D
Sbjct: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462

Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
            AA+++RV  +  +AQEL + +Y+D   +  R   I   W  L  L  SRR+ LE T   
Sbjct: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT-EK 521

Query: 531 QKLFQDMLH---------SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH----------- 570
           Q    D LH           +WM+     L        + E+E L+  H           
Sbjct: 522 QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581

Query: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
           +  EA +AI  +  +   +  +K +    Y    PQ+I  +   ++Q   +  +     +
Sbjct: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641

Query: 631 AQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRG 688
           ++ + ++ L + F  + +    WI+ K +    +    ++   L  Q  H K +E  +  
Sbjct: 642 SKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI--EMNGTLEDQLSHLKQYERSIVD 699

Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
              +L+ + Q+   +     F +      ++ +   W+QL    A   + + + EN
Sbjct: 700 YKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 752



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 71/334 (21%), Positives = 137/334 (41%), Gaps = 45/334 (13%)

Query: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
            +F+  A   +AW      +L   D    E AT    +AL +KH+ F  +L   +  +E +
Sbjct: 417  KFRQKASIHEAWTDGKEAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQI 473

Query: 803  EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
               AQ   E ++ DS +V  R Q + + +  + +    R++ L+      EA+D L+  +
Sbjct: 474  AAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEY 533

Query: 855  GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDIL-------DQEMKTLMTQIDG 906
             +  A    WM    + L +M +  T+E++E +    D         D+E + ++     
Sbjct: 534  AKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILA---- 589

Query: 907  VNLAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV---------DSA 953
            ++  A  + ES H +      Y       +N++W+  Q LV +R  A+         +  
Sbjct: 590  IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649

Query: 954  LRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVD 1012
            LR   +         WI  K   +E    +  ++ G +  Q   L   ER +   +  +D
Sbjct: 650  LR-RQFASQANVVGPWIQTK---MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLD 705

Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
             LE++ Q + ++     +      +H+   W+ L
Sbjct: 706  LLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739



 Score = 44.3 bits (103), Expect = 0.001
 Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 38/270 (14%)

Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
            A++G +KAE   N+  +V A  Q            L++  +K     +A DLL W+   I
Sbjct: 267  AFSGAQKAETAANRICKVLAVNQ--------ENEHLMEDYEK-----LASDLLEWIRRTI 313

Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
              +E +             E  RD   V    K  +    EI   +      L    + +
Sbjct: 314  PWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 373

Query: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAEAWLI 2026
              + +   +I    Q +    K   E+W      R ERL  L E  +F + AS+ EAW  
Sbjct: 374  PSEGKMVSDINNGWQHLEQAEKGY-EEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTD 430

Query: 2027 AQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
             +E  L   D+   T+  ++ LI++HEAFE   A+  +R   +      EL E    +  
Sbjct: 431  GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSH 489

Query: 2086 AEETGPQE--EEGETAGEAPVSHHAATERT 2113
               T  Q+  ++ +  G    S   A E+T
Sbjct: 490  NVNTRCQKICDQWDALGSLTHSRREALEKT 519



 Score = 42.7 bits (99), Expect = 0.004
 Identities = 84/422 (19%), Positives = 159/422 (37%), Gaps = 48/422 (11%)

Query: 1236 AEGNLYSDKIKEKVQLIEDRHRKNNE-KAQEASVLLRDNLELQNFLQNCQELTLWINDKL 1294
            +EG + SD I    Q +E   +   E    E   L R +   + F Q       W + K 
Sbjct: 375  SEGKMVSD-INNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 433

Query: 1295 LTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQ 1352
               +   Y+ A     K L  KH+AF ++LA+H+  +E I A  ++L +     +  V+ 
Sbjct: 434  AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNT 493

Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSS-----DLRLQ---THADLNKWI-SAMED--- 1400
            + + +   WD L + T  + + L            L L+     A  N W+ SAMED   
Sbjct: 494  RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553

Query: 1401 ------------------QLRSD--DPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
                              Q +S   D  ++  ++  +  + +R+ +  +++         
Sbjct: 554  MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613

Query: 1441 QVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLP 1499
              P +   +       + KR   LLE    + KQ  +   + Q +        W++ ++ 
Sbjct: 614  VTPQIINSKWEKVQQLVPKRDHALLE---EQSKQQSNEHLRRQFASQANVVGPWIQTKME 670

Query: 1500 LAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERL 1559
                     N  T++  +   +  +  I+ + P ++ + Q+ Q + EA   D +     +
Sbjct: 671  EIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTM 729

Query: 1560 GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDAD-EAEAWIGEQELYVISDEIPKDEEG 1618
             H++  W++L    A      R  NE +   L  D +  +    QE     +   KD  G
Sbjct: 730  EHIRVGWEQLLTTIA------RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGG 783

Query: 1619 AI 1620
            A+
Sbjct: 784  AL 785



 Score = 42.0 bits (97), Expect = 0.006
 Identities = 55/305 (18%), Positives = 124/305 (40%), Gaps = 38/305 (12%)

Query: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
            W   K  +++        L+ I A+ RK    E D+AA Q RV+ +   +Q+L +     
Sbjct: 428  WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 487

Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
              ++  R + + + W  L       +++L+  E  L  + QL   + +    F  W+   
Sbjct: 488  SHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA 547

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDG-----------HQDSYQRVKESGEKVIQ 1129
             + +    +  ++ E E L+  H   K  +             H+++ QR+ ES    + 
Sbjct: 548  MEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA-QRIAESNHIKLS 606

Query: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN--- 1186
            G     Y  +  ++  +++ W  + ++   R H L +    Q+  +  ++  A  +N   
Sbjct: 607  GSN--PYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVG 662

Query: 1187 -------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGN 1239
                   +E     +E   +LE   + ++++E  +   + N D     ++  ++L+ E  
Sbjct: 663  PWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDL----LEQQHQLIQEAL 718

Query: 1240 LYSDK 1244
            ++ +K
Sbjct: 719  IFDNK 723



 Score = 40.0 bits (92), Expect = 0.024
 Identities = 41/206 (19%), Positives = 88/206 (42%), Gaps = 26/206 (12%)

Query: 1880 EVSAAWQALLDACAG---------RRTQLVD-TADKFRFFSMARDLLSWMESIIRQIETQ 1929
            +++  WQ L  A  G         RR + +D  A+KFR  +   +  +W +     ++ +
Sbjct: 382  DINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLKHR 439

Query: 1930 E-RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988
            +     +S ++ L++ H+   +++            + + L +  +  S  +  + Q++ 
Sbjct: 440  DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499

Query: 1989 SR----------RKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
             +          R+E  EK E + E +  L    ++++ A+    W+ +    L      
Sbjct: 500  DQWDALGSLTHSRREALEKTEKQLEAIDQLH--LEYAKRAAPFNNWMESAMEDLQDMFIV 557

Query: 2039 HTVDSVEKLIKRHEAFEKSTASWAER 2064
            HT++ +E LI  H+ F KST   A+R
Sbjct: 558  HTIEEIEGLISAHDQF-KSTLPDADR 582



 Score = 37.4 bits (85), Expect = 0.16
 Identities = 43/240 (17%), Positives = 90/240 (37%), Gaps = 40/240 (16%)

Query: 800  EHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDA 859
            +HLEQ  +G+ E   +      RL  L E ++Q                       +   
Sbjct: 388  QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ-----------------------KASI 424

Query: 860  CELWMGEKEKWLAEMEMPD-TLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG 918
             E W   KE  L   +    TL D++ +  + +  + ++     +++ +   A  L E  
Sbjct: 425  HEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELD 484

Query: 919  HPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALR-------VH-NYCVDCEETSKWI 970
            +  S  V      +  +W A  +L   RREA++   +       +H  Y       + W+
Sbjct: 485  YYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM 544

Query: 971  TDKTKVVESTKDLG-----RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSH 1025
                  +E  +D+       ++ G+I+   +      D    +  + A+ +E+Q++ +S+
Sbjct: 545  ---ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESN 601


>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
          Length = 887

 Score =  431 bits (1107), Expect = e-120
 Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)

Query: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
           E  Q+KTFT W NSHL +   +I ++ +D RDG  L+ LLEV+SGE L KP +GKMR+H 
Sbjct: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89

Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143

Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
            SAK+ LLLWCQ KTA Y +VN+ NF  SWKDGL F ALIH+HRP+LID+ KL+  +   
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203

Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
           NL  AF+VAE+ L I  +LD ED+  T  PDEK+I+TYV +FYH FS  +       R+ 
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263

Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
           KV+    E E+++E Y  LASDLL WI +TI  L +R   N++  +QQ+L+ F  YR + 
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323

Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
           KPPK QEK  LE+   T+Q+++R +N+  + P +G++VSDIN AW  LE+ E   E  L 
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383

Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
           NE+ R E+L+ LA +F +KA++ E W    + ++ Q ++    L+ ++A  KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443

Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
            AA+++RV  +  +AQEL + +Y+D   + AR   I   W  L  L Q RR+ LE T  L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503

Query: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
            +    +            +WM+     L        + E++ L   H+     L +AD 
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563

Query: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
                + I  +  K +    +       Y    PQ I  +  H+ Q             A
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623

Query: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
           + + ++RL K F  + +    WI+ K +    +    ++   L  Q  H + +E  +   
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681

Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
              ++Q+  +   +     F +      ++ +   W+QL    A   + + + EN
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)

Query: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
           +KL  D+L     +I W++            + L +  D  + HK  +     Q +    
Sbjct: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339

Query: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
                L+ +    + P + +++ D I++   C E++             +LE+   L  K
Sbjct: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398

Query: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
           F  +    E+W   KE +    DY    L+ +  L +KH+AFE +L      +EQI   A
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458

Query: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
             +     +  P + AR +++  QWD L  L    ++ L+  E         + ++   A
Sbjct: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518

Query: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
                W++ A   L    +       + L   H+ F   L + ++ R    G+   + + 
Sbjct: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578

Query: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
            Q +              P+E     D   +L   R+   Q + +   RQQ  +    L 
Sbjct: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632

Query: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
             FG + +    W+  K + +    +EM  TLED      +++      K  + Q++G +
Sbjct: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

Query: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
            L   +L+      ++      +H+   W+   T ++     V++ +
Sbjct: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)

Query: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
            +F+  A   +AW      +L  +D    E AT    +AL KKH+ F  +L   +  +E +
Sbjct: 398  KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454

Query: 803  EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
               AQ   E ++ DSP V  R Q + + +  + A    R++ L+      E +D LY  +
Sbjct: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514

Query: 855  GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
             +  A    WM    + L +  +  T+E+++ +     Q +  + D + + L   I G++
Sbjct: 515  AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572

Query: 909  LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
               + +V++ H        Y       +N +W   + LV  R +A+  + A + HN    
Sbjct: 573  NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632

Query: 959  --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
              +         WI  K   +E    +  ++ G +  Q   L   E+ +   + ++D LE
Sbjct: 633  KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689

Query: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
             + Q + ++     +      +H+   W+ L
Sbjct: 690  GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
            ++ E +QLM++   +  L S  LE + R    L+    E T H    +  D R       
Sbjct: 268  VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324

Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
               +Q    L    + ++ +LR  +    + S  RM++ +      +            Q
Sbjct: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373

Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
            V    E+G +  L  E R L+ L+ L  + +Q  S                W + +  + 
Sbjct: 374  V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417

Query: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
            +  DY T  L  ++  +KK++  ++++  H  RVE +    Q+L E    D   +  R  
Sbjct: 418  RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477

Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
             +   WD L        Q+ R+A E  +  L+
Sbjct: 478  KICDQWDNL----GALTQKRREALERTEKLLE 505



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)

Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
            A++G +KAE   N+  +V A  Q           QL++  +K     +A DLL W+   I
Sbjct: 248  AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294

Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
              +E +             E  RD   +    K  +    EI   +      L    + +
Sbjct: 295  PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354

Query: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
              + +   +I      L+QV    +E       R ERL  L E  +F + AS+ EAW   
Sbjct: 355  PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412

Query: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
            +E  L   D+   T+  ++ L+K+HEAFE   A+  +R   +      EL E    + P+
Sbjct: 413  KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471

Query: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
                 Q+  ++ +  G        A ERT
Sbjct: 472  VNARCQKICDQWDNLGALTQKRREALERT 500



 Score = 38.5 bits (88), Expect = 0.071
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)

Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
            + F Q       W + K    +   Y+ A     K L  KH+AF ++LA+H+  +E I A
Sbjct: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
              ++L +     +  V+ + + +   WD L A T+++ + L            L L+   
Sbjct: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516

Query: 1387 THADLNKWI-SAMED 1400
              A  N W+  AMED
Sbjct: 517  RAAPFNNWMEGAMED 531



 Score = 37.4 bits (85), Expect = 0.16
 Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)

Query: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
            W   K  ++         L+ I A+ +K    E D+AA Q RV+ +   +Q+L +     
Sbjct: 409  WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468

Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
               +  R + + + W  L       +++L+  E LL  + QL               +  
Sbjct: 469  SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528

Query: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
            ++DL D         I     A E    +LP+A++      GI +E+     +Y      
Sbjct: 529  MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583

Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
               V    T+P   +  Q + G    W+ + ++   R   L +    Q+  +  ++    
Sbjct: 584  ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637

Query: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
             +N          +E     +E   +LE   + +R++E    S+ N + K+   ++  ++
Sbjct: 638  QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693

Query: 1234 LVAEGNLYSDK 1244
            L+ E  ++ +K
Sbjct: 694  LIQEALIFDNK 704



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)

Query: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
            RR + +D  A+KFR  +   +  +W    E+++RQ + +     +S ++ L+K H+   +
Sbjct: 387  RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442

Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
            ++            + + L +  +  S  +  + Q++  +   +    +K     ER   
Sbjct: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502

Query: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
            LLE       ++++ A+    W+      L      HT++ ++ L   HE F+
Sbjct: 503  LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555


>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
          Length = 914

 Score =  431 bits (1107), Expect = e-120
 Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)

Query: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
           E  Q+KTFT W NSHL +   +I ++ +D RDG  L+ LLEV+SGE L KP +GKMR+H 
Sbjct: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89

Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143

Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
            SAK+ LLLWCQ KTA Y +VN+ NF  SWKDGL F ALIH+HRP+LID+ KL+  +   
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203

Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
           NL  AF+VAE+ L I  +LD ED+  T  PDEK+I+TYV +FYH FS  +       R+ 
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263

Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
           KV+    E E+++E Y  LASDLL WI +TI  L +R   N++  +QQ+L+ F  YR + 
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323

Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
           KPPK QEK  LE+   T+Q+++R +N+  + P +G++VSDIN AW  LE+ E   E  L 
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383

Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
           NE+ R E+L+ LA +F +KA++ E W    + ++ Q ++    L+ ++A  KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443

Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
            AA+++RV  +  +AQEL + +Y+D   + AR   I   W  L  L Q RR+ LE T  L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503

Query: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
            +    +            +WM+     L        + E++ L   H+     L +AD 
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563

Query: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
                + I  +  K +    +       Y    PQ I  +  H+ Q             A
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623

Query: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
           + + ++RL K F  + +    WI+ K +    +    ++   L  Q  H + +E  +   
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681

Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
              ++Q+  +   +     F +      ++ +   W+QL    A   + + + EN
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)

Query: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
           +KL  D+L     +I W++            + L +  D  + HK  +     Q +    
Sbjct: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339

Query: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
                L+ +    + P + +++ D I++   C E++             +LE+   L  K
Sbjct: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398

Query: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
           F  +    E+W   KE +    DY    L+ +  L +KH+AFE +L      +EQI   A
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458

Query: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
             +     +  P + AR +++  QWD L  L    ++ L+  E         + ++   A
Sbjct: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518

Query: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
                W++ A   L    +       + L   H+ F   L + ++ R    G+   + + 
Sbjct: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578

Query: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
            Q +              P+E     D   +L   R+   Q + +   RQQ  +    L 
Sbjct: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632

Query: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
             FG + +    W+  K + +    +EM  TLED      +++      K  + Q++G +
Sbjct: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

Query: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
            L   +L+      ++      +H+   W+   T ++     V++ +
Sbjct: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)

Query: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
            +F+  A   +AW      +L  +D    E AT    +AL KKH+ F  +L   +  +E +
Sbjct: 398  KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454

Query: 803  EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
               AQ   E ++ DSP V  R Q + + +  + A    R++ L+      E +D LY  +
Sbjct: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514

Query: 855  GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
             +  A    WM    + L +  +  T+E+++ +     Q +  + D + + L   I G++
Sbjct: 515  AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572

Query: 909  LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
               + +V++ H        Y       +N +W   + LV  R +A+  + A + HN    
Sbjct: 573  NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632

Query: 959  --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
              +         WI  K   +E    +  ++ G +  Q   L   E+ +   + ++D LE
Sbjct: 633  KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689

Query: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
             + Q + ++     +      +H+   W+ L
Sbjct: 690  GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
            ++ E +QLM++   +  L S  LE + R    L+    E T H    +  D R       
Sbjct: 268  VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324

Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
               +Q    L    + ++ +LR  +    + S  RM++ +      +            Q
Sbjct: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373

Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
            V    E+G +  L  E R L+ L+ L  + +Q  S                W + +  + 
Sbjct: 374  V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417

Query: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
            +  DY T  L  ++  +KK++  ++++  H  RVE +    Q+L E    D   +  R  
Sbjct: 418  RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477

Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
             +   WD L        Q+ R+A E  +  L+
Sbjct: 478  KICDQWDNL----GALTQKRREALERTEKLLE 505



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)

Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
            A++G +KAE   N+  +V A  Q           QL++  +K     +A DLL W+   I
Sbjct: 248  AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294

Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
              +E +             E  RD   +    K  +    EI   +      L    + +
Sbjct: 295  PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354

Query: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
              + +   +I      L+QV    +E       R ERL  L E  +F + AS+ EAW   
Sbjct: 355  PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412

Query: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
            +E  L   D+   T+  ++ L+K+HEAFE   A+  +R   +      EL E    + P+
Sbjct: 413  KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471

Query: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
                 Q+  ++ +  G        A ERT
Sbjct: 472  VNARCQKICDQWDNLGALTQKRREALERT 500



 Score = 38.5 bits (88), Expect = 0.071
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)

Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
            + F Q       W + K    +   Y+ A     K L  KH+AF ++LA+H+  +E I A
Sbjct: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
              ++L +     +  V+ + + +   WD L A T+++ + L            L L+   
Sbjct: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516

Query: 1387 THADLNKWI-SAMED 1400
              A  N W+  AMED
Sbjct: 517  RAAPFNNWMEGAMED 531



 Score = 37.4 bits (85), Expect = 0.16
 Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)

Query: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
            W   K  ++         L+ I A+ +K    E D+AA Q RV+ +   +Q+L +     
Sbjct: 409  WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468

Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
               +  R + + + W  L       +++L+  E LL  + QL               +  
Sbjct: 469  SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528

Query: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
            ++DL D         I     A E    +LP+A++      GI +E+     +Y      
Sbjct: 529  MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583

Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
               V    T+P   +  Q + G    W+ + ++   R   L +    Q+  +  ++    
Sbjct: 584  ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637

Query: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
             +N          +E     +E   +LE   + +R++E    S+ N + K+   ++  ++
Sbjct: 638  QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693

Query: 1234 LVAEGNLYSDK 1244
            L+ E  ++ +K
Sbjct: 694  LIQEALIFDNK 704



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)

Query: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
            RR + +D  A+KFR  +   +  +W    E+++RQ + +     +S ++ L+K H+   +
Sbjct: 387  RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442

Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
            ++            + + L +  +  S  +  + Q++  +   +    +K     ER   
Sbjct: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502

Query: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
            LLE       ++++ A+    W+      L      HT++ ++ L   HE F+
Sbjct: 503  LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555


>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
          Length = 892

 Score =  431 bits (1107), Expect = e-120
 Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)

Query: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
           E  Q+KTFT W NSHL +   +I ++ +D RDG  L+ LLEV+SGE L KP +GKMR+H 
Sbjct: 30  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89

Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 90  ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143

Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
            SAK+ LLLWCQ KTA Y +VN+ NF  SWKDGL F ALIH+HRP+LID+ KL+  +   
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203

Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
           NL  AF+VAE+ L I  +LD ED+  T  PDEK+I+TYV +FYH FS  +       R+ 
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263

Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
           KV+    E E+++E Y  LASDLL WI +TI  L +R   N++  +QQ+L+ F  YR + 
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323

Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
           KPPK QEK  LE+   T+Q+++R +N+  + P +G++VSDIN AW  LE+ E   E  L 
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383

Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
           NE+ R E+L+ LA +F +KA++ E W    + ++ Q ++    L+ ++A  KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443

Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
            AA+++RV  +  +AQEL + +Y+D   + AR   I   W  L  L Q RR+ LE T  L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503

Query: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
            +    +            +WM+     L        + E++ L   H+     L +AD 
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563

Query: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
                + I  +  K +    +       Y    PQ I  +  H+ Q             A
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623

Query: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
           + + ++RL K F  + +    WI+ K +    +    ++   L  Q  H + +E  +   
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681

Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
              ++Q+  +   +     F +      ++ +   W+QL    A   + + + EN
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733



 Score = 55.8 bits (133), Expect = 4e-07
 Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)

Query: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
           +KL  D+L     +I W++            + L +  D  + HK  +     Q +    
Sbjct: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339

Query: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
                L+ +    + P + +++ D I++   C E++             +LE+   L  K
Sbjct: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398

Query: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
           F  +    E+W   KE +    DY    L+ +  L +KH+AFE +L      +EQI   A
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458

Query: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
             +     +  P + AR +++  QWD L  L    ++ L+  E         + ++   A
Sbjct: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518

Query: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
                W++ A   L    +       + L   H+ F   L + ++ R    G+   + + 
Sbjct: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578

Query: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
            Q +              P+E     D   +L   R+   Q + +   RQQ  +    L 
Sbjct: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632

Query: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
             FG + +    W+  K + +    +EM  TLED      +++      K  + Q++G +
Sbjct: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692

Query: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
            L   +L+      ++      +H+   W+   T ++     V++ +
Sbjct: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)

Query: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
            +F+  A   +AW      +L  +D    E AT    +AL KKH+ F  +L   +  +E +
Sbjct: 398  KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454

Query: 803  EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
               AQ   E ++ DSP V  R Q + + +  + A    R++ L+      E +D LY  +
Sbjct: 455  AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514

Query: 855  GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
             +  A    WM    + L +  +  T+E+++ +     Q +  + D + + L   I G++
Sbjct: 515  AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572

Query: 909  LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
               + +V++ H        Y       +N +W   + LV  R +A+  + A + HN    
Sbjct: 573  NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632

Query: 959  --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
              +         WI  K   +E    +  ++ G +  Q   L   E+ +   + ++D LE
Sbjct: 633  KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689

Query: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
             + Q + ++     +      +H+   W+ L
Sbjct: 690  GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720



 Score = 48.5 bits (114), Expect = 7e-05
 Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
            ++ E +QLM++   +  L S  LE + R    L+    E T H    +  D R       
Sbjct: 268  VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324

Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
               +Q    L    + ++ +LR  +    + S  RM++ +      +            Q
Sbjct: 325  PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373

Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
            V    E+G +  L  E R L+ L+ L  + +Q  S                W + +  + 
Sbjct: 374  V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417

Query: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
            +  DY T  L  ++  +KK++  ++++  H  RVE +    Q+L E    D   +  R  
Sbjct: 418  RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477

Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
             +   WD L        Q+ R+A E  +  L+
Sbjct: 478  KICDQWDNL----GALTQKRREALERTEKLLE 505



 Score = 48.1 bits (113), Expect = 9e-05
 Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)

Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
            A++G +KAE   N+  +V A  Q           QL++  +K     +A DLL W+   I
Sbjct: 248  AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294

Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
              +E +             E  RD   +    K  +    EI   +      L    + +
Sbjct: 295  PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354

Query: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
              + +   +I      L+QV    +E       R ERL  L E  +F + AS+ EAW   
Sbjct: 355  PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412

Query: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
            +E  L   D+   T+  ++ L+K+HEAFE   A+  +R   +      EL E    + P+
Sbjct: 413  KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471

Query: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
                 Q+  ++ +  G        A ERT
Sbjct: 472  VNARCQKICDQWDNLGALTQKRREALERT 500



 Score = 38.5 bits (88), Expect = 0.071
 Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)

Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
            + F Q       W + K    +   Y+ A     K L  KH+AF ++LA+H+  +E I A
Sbjct: 397  EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
              ++L +     +  V+ + + +   WD L A T+++ + L            L L+   
Sbjct: 457  IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516

Query: 1387 THADLNKWI-SAMED 1400
              A  N W+  AMED
Sbjct: 517  RAAPFNNWMEGAMED 531



 Score = 37.4 bits (85), Expect = 0.16
 Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)

Query: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
            W   K  ++         L+ I A+ +K    E D+AA Q RV+ +   +Q+L +     
Sbjct: 409  WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468

Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
               +  R + + + W  L       +++L+  E LL  + QL               +  
Sbjct: 469  SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528

Query: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
            ++DL D         I     A E    +LP+A++      GI +E+     +Y      
Sbjct: 529  MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583

Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
               V    T+P   +  Q + G    W+ + ++   R   L +    Q+  +  ++    
Sbjct: 584  ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637

Query: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
             +N          +E     +E   +LE   + +R++E    S+ N + K+   ++  ++
Sbjct: 638  QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693

Query: 1234 LVAEGNLYSDK 1244
            L+ E  ++ +K
Sbjct: 694  LIQEALIFDNK 704



 Score = 36.2 bits (82), Expect = 0.35
 Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)

Query: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
            RR + +D  A+KFR  +   +  +W    E+++RQ + +     +S ++ L+K H+   +
Sbjct: 387  RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442

Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
            ++            + + L +  +  S  +  + Q++  +   +    +K     ER   
Sbjct: 443  DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502

Query: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
            LLE       ++++ A+    W+      L      HT++ ++ L   HE F+
Sbjct: 503  LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555


>gi|4501893 actinin, alpha 2 [Homo sapiens]
          Length = 894

 Score =  416 bits (1070), Expect = e-115
 Identities = 252/653 (38%), Positives = 367/653 (56%), Gaps = 38/653 (5%)

Query: 31  DNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIK 90
           D D    +  E  R   L    E  Q+KTFT W NSHL +   +I ++ +D R+G  L+ 
Sbjct: 15  DEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLML 74

Query: 91  LLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLI 150
           LLEV+SGE LPKP +GKMR H + NV+KAL ++  + V L ++G+ +IVDGN ++ LG+I
Sbjct: 75  LLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMI 134

Query: 151 WTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNA 210
           WTIILRF IQDI V      E  SAK+ LLLWCQ KTA Y +VN+ NF +SWKDGL   A
Sbjct: 135 WTIILRFAIQDISV------EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCA 188

Query: 211 LIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITY 269
           LIH+HRPDLID+ KL   +   N+  A  +AE+ L I  +LD ED+  T  PDE++I+TY
Sbjct: 189 LIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTY 248

Query: 270 VVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRK 329
           V  FYH F+  +       R+ KV+    E E+++E+Y  LAS+LL WI +TI  L +R 
Sbjct: 249 VSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRT 308

Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
              ++  +Q++L+ F  YR   KPPK QEK  LE+   T+Q+++R +N+  + P +GK+V
Sbjct: 309 PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMV 368

Query: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETW-LSENQRLVAQD 448
           SDI  AW+ LE+AE   E  L NE+ R E+LE LA +F +KA+  ETW   + Q L+ +D
Sbjct: 369 SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428

Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
                L  V A  +KHEA E+D AA+++RV  +  +AQEL + +YHD   +  R   I  
Sbjct: 429 YESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488

Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQ--DMLH---------SIDWMDEIKAHLLSAEFG 557
            W  L  L Q RR+ LE    ++KL +  D LH           +WM+     L      
Sbjct: 489 QWDRLGTLTQKRREALE---RMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIV 545

Query: 558 KHLLEVEDLLQKHK-----LMEAD------IAIQGDKVKAITAATLKFTEGKGYQPCDPQ 606
             + E++ L+  H+     L EAD      +AIQ +  K I +  ++ +    Y      
Sbjct: 546 HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD 605

Query: 607 VIQ---DRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEK 656
            ++   D++  L    ++       R+   E+ +R  +F  + +    WI+ K
Sbjct: 606 ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRR--QFAAQANAIGPWIQNK 656



 Score = 71.6 bits (174), Expect = 8e-12
 Identities = 98/459 (21%), Positives = 179/459 (38%), Gaps = 44/459 (9%)

Query: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591
           +L + +  +I W++            K L +  D  +KHK  +     Q +         
Sbjct: 292 ELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTK 351

Query: 592 LKFTEGKGYQPCDPQVIQD------RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWE 645
           L+ +    + P + +++ D      R+   E+ +EE       R  +LE      KF  +
Sbjct: 352 LRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQK 409

Query: 646 MDEAESWIKEKEQIYSSLDY-GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
               E+W   KEQI    DY    LT V  L RKH+AFE +L      +EQI   A  + 
Sbjct: 410 ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469

Query: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLK 756
                    +  R +++  QWD+L  L    ++ L+  E           +F   A    
Sbjct: 470 ELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFN 529

Query: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRG-------VMEHLEQQAQGF 809
            W++ A   L    +       ++L   H+ F   L E+ G       +   +E+  Q +
Sbjct: 530 NWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY 589

Query: 810 PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEAL-------DLYTVF-GETDAC 860
                 S P  T  +  LR  + +V     +R Q LQE L        L   F  + +A 
Sbjct: 590 NIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAI 649

Query: 861 ELWMGEKEKWLA--EMEMPDTLEDL--EVVQHRFDILDQEMKTLMTQIDGVN-LAANSLV 915
             W+  K + +A   +++   LED   ++ Q+  +I++   K  + +++G + L   +LV
Sbjct: 650 GPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIIN--YKNNIDKLEGDHQLIQEALV 707

Query: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
                 ++      +H+   W+   T ++     V++ +
Sbjct: 708 FD----NKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742



 Score = 58.9 bits (141), Expect = 5e-08
 Identities = 62/303 (20%), Positives = 129/303 (42%), Gaps = 34/303 (11%)

Query: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
            W   K +++         L  + A+ RK    E D+AA Q RV+ +   +Q+L +     
Sbjct: 416  WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD 475

Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
              ++  R + + + W  L       +++L+  E LL  + QL   F +    F  W+   
Sbjct: 476  AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQ------GQ 1131
             + +    +  S+ E + L+  H   K    E DG + S   ++   EKVIQ        
Sbjct: 536  MEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISS 595

Query: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN----- 1186
            ++P   +    ++ L T W+ + ++   R  +L + L  Q   +  ++  A  +N     
Sbjct: 596  SNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652

Query: 1187 -----QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241
                 +E   + ++   +LE     ++++E  + + +NN DK    ++  ++L+ E  ++
Sbjct: 653  IQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDK----LEGDHQLIQEALVF 708

Query: 1242 SDK 1244
             +K
Sbjct: 709  DNK 711



 Score = 50.8 bits (120), Expect = 1e-05
 Identities = 58/266 (21%), Positives = 108/266 (40%), Gaps = 47/266 (17%)

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
            ++ E ++LM+E   +  L S+ LE + R    L+  T EKT      +  D R       
Sbjct: 275  VNQENERLMEE---YERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331

Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
               +Q    L    + ++ +LR  +    + S  +M++ +     ++             
Sbjct: 332  PPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE------------ 379

Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
                 E+G +  L  E R L+ LE L  + +Q  S+            ET W   +  + 
Sbjct: 380  ---QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTH-----------ET-WAYGKEQIL 424

Query: 1502 QSADY-GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
               DY   +L  V+  ++K++  ++++  H  RVE +    Q+L E    D  ++ +R  
Sbjct: 425  LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484

Query: 1561 HLQSSWDRL------REAAAGRLQRL 1580
             +   WDRL      R  A  R+++L
Sbjct: 485  KICDQWDRLGTLTQKRREALERMEKL 510



 Score = 47.4 bits (111), Expect = 2e-04
 Identities = 42/237 (17%), Positives = 100/237 (42%), Gaps = 11/237 (4%)

Query: 301 EKMIE-------KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKP 353
           EK++E       +++  A+    W+E  +  L      +S+  +Q  + A   ++    P
Sbjct: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566

Query: 354 PKFQEKGNLEVLLFTIQSRMRANNQKVYT--PHDGKLVSDINRAWESLEEAEYRRELALR 411
               E+ ++  +   ++  +++ N ++ +  P+    + ++   W+ +++    R+ +L+
Sbjct: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626

Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDT 471
            EL RQ   E+L R+F  +A     W+      +A+ +      A+E    + +  E + 
Sbjct: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685

Query: 472 AAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
             Y+  +  LE   Q +++    D K      ++I   W  L   +      +ET +
Sbjct: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 37/195 (18%), Positives = 81/195 (41%), Gaps = 21/195 (10%)

Query: 1880 EVSAAWQALLDACAG----------RRTQLVDTADKFRFFSMARDLLSW-MESIIRQIET 1928
            +++ AWQ L  A  G          R  +L   A+KFR  +   +  ++  E I+ Q + 
Sbjct: 370  DIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDY 429

Query: 1929 QERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988
            +     ++ V  L++ H+   +++            + + L +  +  +  + ++ Q++ 
Sbjct: 430  ESA--SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487

Query: 1989 S---RRKEMNEKWEARWERLRMLLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHT 2040
                R   + +K     ER+  LLE       +F++ A+    W+      L      H+
Sbjct: 488  DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547

Query: 2041 VDSVEKLIKRHEAFE 2055
            ++ ++ LI  HE F+
Sbjct: 548  IEEIQSLITAHEQFK 562



 Score = 40.0 bits (92), Expect = 0.024
 Identities = 50/218 (22%), Positives = 93/218 (42%), Gaps = 33/218 (15%)

Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
            A+AG E+AE   N+  +V A  Q           +L++  ++     +A +LL W+   I
Sbjct: 255  AFAGAEQAETAANRICKVLAVNQ--------ENERLMEEYER-----LASELLEWIRRTI 301

Query: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE---- 1979
              +E +   + + +++  ++  +    + +         LE+  + LQ + + S      
Sbjct: 302  PWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM 361

Query: 1980 -IREKLQQVMS---RRKEMNEKWEARW--------ERLRMLLEVCQFSRDASVAEAWLIA 2027
                K+   ++   +R E  EK    W        ERL  L E  +F + AS  E W   
Sbjct: 362  PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYG 419

Query: 2028 QEPYLASGDF-GHTVDSVEKLIKRHEAFEKSTASWAER 2064
            +E  L   D+   ++  V  L+++HEAFE   A+  +R
Sbjct: 420  KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457



 Score = 36.6 bits (83), Expect = 0.27
 Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 11/135 (8%)

Query: 1277 QNFLQNCQELTLWI--NDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
            + F Q       W    +++L  +D        +     KH+AF ++LA+H+  +E I A
Sbjct: 404  EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
              ++L +        V+ + + +   WD L   T+++ + L            L L+   
Sbjct: 464  IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523

Query: 1387 THADLNKWI-SAMED 1400
              A  N W+  AMED
Sbjct: 524  RAAPFNNWMEGAMED 538


>gi|4557241 actinin, alpha 3 [Homo sapiens]
          Length = 901

 Score =  409 bits (1052), Expect = e-113
 Identities = 248/638 (38%), Positives = 358/638 (56%), Gaps = 32/638 (5%)

Query: 53  EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
           E  Q+KTFT W NSHL +   +I ++ +D R+G  L+ LLEV+SGE LP+P KGKMR H 
Sbjct: 44  EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103

Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
           + NV+KAL F+  + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V      E 
Sbjct: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EE 157

Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
            SAK+ LLLWCQ KTA Y +VNV NF +SWKDGLA  ALIH+HRPDLID+ KL+  +   
Sbjct: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217

Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
           NL  AF VAE+ L I  +LD ED+  T  PDEK+I+TYV  FYH F+  +       R+ 
Sbjct: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277

Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
           KV+    E EK++E+Y  LAS+LL WI +T+  L +R    S++ +Q++L+ F  YR + 
Sbjct: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337

Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
           KPP+ QEK  LE+   T+Q+++R +++  + P +GKLVSDI  AW  LE+ E   E  L 
Sbjct: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397

Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYD---LAAVEAAKKKHEAIE 468
           +E+ R ++L+ LA +F +KA++ E W    + +++Q +  YD   L  V A  ++HEA E
Sbjct: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRD--YDSALLQEVRALLRRHEAFE 455

Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
           +D AA+++RV  +  LAQEL + +YH+   + +R   I   W  L  L Q RR  LE   
Sbjct: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515

Query: 529 ALQKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKH-----KLMEA 575
            L +    +            +W+D     L        + E + LL  H      L EA
Sbjct: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575

Query: 576 D------IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
           D      + IQG+  K      L+      Y    PQ I  +   + +            
Sbjct: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEE 635

Query: 630 KAQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYG 666
            A+ + ++RL + F  + +    WI+ K +    L  G
Sbjct: 636 LARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAG 673



 Score = 54.7 bits (130), Expect = 1e-06
 Identities = 66/303 (21%), Positives = 130/303 (42%), Gaps = 34/303 (11%)

Query: 969  WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
            W   K +++         L  + A+ R+    E D+AA Q RV+ +   +Q+L +    +
Sbjct: 423  WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHE 482

Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
               +  R + + + W  L       + +L+  E LL  + QLQ  F +    F  WL   
Sbjct: 483  AASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGA 542

Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQG------Q 1131
             + +    +  S+ E + LL  H   K    E D  + +   ++   +K+ Q        
Sbjct: 543  VEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCS 602

Query: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ--EY 1189
            T+P Y+ L    + ++T W+ + ++  SR  TL + L  Q+  +  ++  A  +N    +
Sbjct: 603  TNP-YITLSP--QDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPW 659

Query: 1190 TLAHLEP--------PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241
              A +E           SLE   AG+R+ E  + + + N D+    ++  ++L+ E  ++
Sbjct: 660  IQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR----LEGDHQLLQESLVF 715

Query: 1242 SDK 1244
             +K
Sbjct: 716  DNK 718



 Score = 52.8 bits (125), Expect = 4e-06
 Identities = 69/338 (20%), Positives = 126/338 (37%), Gaps = 21/338 (6%)

Query: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591
           +L + +  ++ W++        +   + L +  D  + HK        Q +         
Sbjct: 299 ELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTK 358

Query: 592 LKFTEGKGYQPCDPQVIQDRISH---LEQCFEELSNMAAGRKAQLEQSKRLW-KFFWEMD 647
           L+ +    + P + +++ D  +    LEQ  +   +       +L++ + L  KF  +  
Sbjct: 359 LRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKAS 418

Query: 648 EAESWIKEKEQIYSSLDYGKDLTS-VLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVAR 706
             E+W + KE++ S  DY   L   V  L R+H+AFE +L      +E I   A  +   
Sbjct: 419 LHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNEL 478

Query: 707 KQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLKAW 758
                  + +R + +  QWD L  L    +  L+  E           +F   A     W
Sbjct: 479 DYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNW 538

Query: 759 LQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESRGVMEHLEQQAQGFPEEF-- 813
           L  A   L    +      T++L   H  F   L E +  RG +  ++ + Q   + +  
Sbjct: 539 LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGL 598

Query: 814 ---RDSPDVTHRLQALRELYQQVVAQADLRQQRLQEAL 848
                +P +T   Q +   +  V      R Q LQE L
Sbjct: 599 RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL 636



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 79/338 (23%), Positives = 137/338 (40%), Gaps = 45/338 (13%)

Query: 747  QFQGDADDLKAWLQDAHRLLSGEDVGQDE-GATRALGKKHKDFLEELEESRGVMEHLEQQ 805
            +F+  A   +AW +    +LS  D         RAL ++H+ F  +L   +  +EH+   
Sbjct: 412  KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAAL 471

Query: 806  AQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELW 863
            AQ   E ++ ++  V  R QA+ + +  +     L Q+R ++AL+      ET D  +L 
Sbjct: 472  AQELNELDYHEAASVNSRCQAICDQWDNL---GTLTQKR-RDALERMEKLLETIDQLQLE 527

Query: 864  MGEK----EKWL--AEMEMPDT--LEDLEVVQHRFDILDQEMKTLMTQ------IDGVNL 909
               +      WL  A  ++ D   +  +E  Q      DQ   TL         I G+  
Sbjct: 528  FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQG 587

Query: 910  AANSLVESGHPRSREVKQY-----QDHLNTRWQAFQTLVSER---------REAVDSALR 955
                + ++   R      Y     QD +NT+W   + LV  R         R+ V+  LR
Sbjct: 588  EIQKICQTYGLRPCSTNPYITLSPQD-INTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646

Query: 956  VHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGL---ERDVAAIQARVD 1012
               +         WI  K   VE    L   LAG  +++ +++GL   E+++   +  +D
Sbjct: 647  -RQFAAQANAIGPWIQAK---VEEVGRLAAGLAG--SLEEQMAGLRQQEQNIINYKTNID 700

Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
             LE + Q L +S     +      +H+   W+ L  S+
Sbjct: 701  RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI 738



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 12/142 (8%)

Query: 1033 GQRQKHLEELWQGLQQSLQGQED-LLGEVSQLQ-------AFLQDLDDFQAWLSITQKAV 1084
            G+    +   W+GL+Q  +G ED LL E+ +LQ        F Q     +AW    ++ +
Sbjct: 372  GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431

Query: 1085 ASEDMPES-LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTD-PEYLLLGQR 1142
            +  D   + L E   LL++H   + ++  HQD  + +    +++   + D  E   +  R
Sbjct: 432  SQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL--NELDYHEAASVNSR 489

Query: 1143 LEGLDTGWNALGRMWESRSHTL 1164
             + +   W+ LG + + R   L
Sbjct: 490  CQAICDQWDNLGTLTQKRRDAL 511



 Score = 42.4 bits (98), Expect = 0.005
 Identities = 32/138 (23%), Positives = 60/138 (43%), Gaps = 7/138 (5%)

Query: 1456 IEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL-QTVQ 1514
            +EK + D L    RR ++L+    K +    L +   W   +  +    DY + L Q V+
Sbjct: 388  VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVR 445

Query: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
              +++++  ++++  H  RVE +    Q+L E    +   +  R   +   WD L     
Sbjct: 446  ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT- 504

Query: 1575 GRLQRLRDANEAQQYYLD 1592
               Q+ RDA E  +  L+
Sbjct: 505  ---QKRRDALERMEKLLE 519



 Score = 40.0 bits (92), Expect = 0.024
 Identities = 24/65 (36%), Positives = 37/65 (56%), Gaps = 3/65 (4%)

Query: 2001 RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTV-DSVEKLIKRHEAFEKSTA 2059
            R +RL+ L E  +F + AS+ EAW   +E  L+  D+   +   V  L++RHEAFE   A
Sbjct: 402  RLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLA 459

Query: 2060 SWAER 2064
            +  +R
Sbjct: 460  AHQDR 464



 Score = 38.1 bits (87), Expect = 0.093
 Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 11/135 (8%)

Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEA--RNLHNKWLKHQAFVAELASHEGWLENIDA 1334
            + F Q       W   K        YD A  + +     +H+AF ++LA+H+  +E+I A
Sbjct: 411  EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470

Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
              ++L +      A V+ + +A+   WD L   T+++   L            L+L+   
Sbjct: 471  LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530

Query: 1387 THADLNKWI-SAMED 1400
              A  N W+  A+ED
Sbjct: 531  RAAPFNNWLDGAVED 545



 Score = 35.0 bits (79), Expect = 0.79
 Identities = 27/146 (18%), Positives = 62/146 (42%), Gaps = 6/146 (4%)

Query: 810 PEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
           P E +   D+ +  + L ++   Y+  +     R QRLQ   + +    +    E W   
Sbjct: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQ--KASLHEAWTRG 426

Query: 867 KEKWLAEMEMPDTL-EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREV 925
           KE+ L++ +    L +++  +  R +  + ++     +++ +   A  L E  +  +  V
Sbjct: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486

Query: 926 KQYQDHLNTRWQAFQTLVSERREAVD 951
                 +  +W    TL  +RR+A++
Sbjct: 487 NSRCQAICDQWDNLGTLTQKRRDALE 512



 Score = 35.0 bits (79), Expect = 0.79
 Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 14/133 (10%)

Query: 1667 QVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL-EQWISEKELVASSPEMGQDFDHV 1725
            QV+K Y   +D      R+L+ + HL +  R+   L E W   KE + S     +D+D  
Sbjct: 387  QVEKGY---EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQ----RDYDSA 439

Query: 1726 TL-----LRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
             L     L  +   F  +  A  Q+RV+++ A  + L +  + EAA++      + + W 
Sbjct: 440  LLQEVRALLRRHEAFESDLAA-HQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498

Query: 1781 DLLELIDTRMQLL 1793
            +L  L   R   L
Sbjct: 499  NLGTLTQKRRDAL 511


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  376 bits (966), Expect = e-103
 Identities = 532/2209 (24%), Positives = 910/2209 (41%), Gaps = 280/2209 (12%)

Query: 42   RSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLP 101
            ++ I +L DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP
Sbjct: 8    QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67

Query: 102  KPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQD 161
            +  KG+MR H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI D
Sbjct: 68   RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126

Query: 162  IVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLID 221
            I V  Q   E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID
Sbjct: 127  IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184

Query: 222  FDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMK 281
             +K+       NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++ 
Sbjct: 185  MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244

Query: 282  VLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQL 341
             +  +G R       A E +   ++Y  L   LL W+         R+F +S   ++   
Sbjct: 245  DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296

Query: 342  QAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEE 401
              F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  
Sbjct: 297  SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353

Query: 402  AEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461
            A   RE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A     
Sbjct: 354  AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410

Query: 462  KKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILR 508
            ++   +E D    +  +R L +  Q L K+  H Q             + +  R +  LR
Sbjct: 411  QRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469

Query: 509  L--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHL 560
            L            Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L
Sbjct: 470  LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDL 526

Query: 561  LEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFE 620
              VE  L  H+ +   I     K++       +  EG+   P      +D +  L+  + 
Sbjct: 527  PSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYA 580

Query: 621  ELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHK 680
            +L N +   KA+L   + L  F     +   W+ EKE+     D+    T++   +  + 
Sbjct: 581  KLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637

Query: 681  AFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQ 740
            A   EL   +  ++++      ++       P +E+    +  QW  +  L    + +L+
Sbjct: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697

Query: 741  DAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESR 796
            +   +FQF  D  + +  LQ     L       D  AT      L +  +D  E+L E +
Sbjct: 698  ENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756

Query: 797  GVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGE 856
            G +  L ++A+   +     P   H ++    L    +A  D +Q        +     +
Sbjct: 757  GHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHK 802

Query: 857  TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE 916
             D C+L +G  +                             K L +   G   A  S+  
Sbjct: 803  GDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCF 834

Query: 917  SGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKV 976
               P ++E ++    L  + QA  TL              H   VD +    W       
Sbjct: 835  LVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------- 874

Query: 977  VESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK- 1029
                + L RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE + 
Sbjct: 875  ----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 930

Query: 1030 ---EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVA 1085
                + G    H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V 
Sbjct: 931  MAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVH 983

Query: 1086 SEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQ 1141
               +P   E   E  Q + +    + E++G      R+    EKV+   +  P    L  
Sbjct: 984  RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1043

Query: 1142 RLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPD 1198
             LE        LG++ + RS +   L +        +  + AE +L   E  L   +   
Sbjct: 1044 ELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1097

Query: 1199 S----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKE 1247
            +    LEA +A ++K     E    + +  RD++    + G +L     E ++  ++ +E
Sbjct: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157

Query: 1248 KVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS-- 1301
            +V  + +R +    + + + +E   L R   +L+ + ++   L  W+ D     + +   
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAM 1214

Query: 1302 -YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHR 1359
               +++ +  +  + QA + E+  H   +E      KQ ++  K     LV+ K +    
Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL--- 1271

Query: 1360 LWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDL 1411
               E  A+  +K +  S + S     + L+TH        +++I  + + LR  +  + L
Sbjct: 1272 ---EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328

Query: 1412 TSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470
                R   + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R 
Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRRE 1383

Query: 1471 KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH 1530
            +  +++ + K  I  +L        ++L  +  A+     +  +   +    ++ EI   
Sbjct: 1384 EAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435

Query: 1531 TPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587
              ++E    QRG  +  ++A     ++ E +    Q   +RLR       QR R A    
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495

Query: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647
               + A EAEA   +Q      +E+    E A    +R LRQ  A  +  R ++     A
Sbjct: 1496 ASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETA 1548

Query: 1648 Q-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-D 1701
            Q      L S      E+  +L+  + + +  +  + EE +R+ +      + + E + +
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608

Query: 1702 LEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVD 1748
            LE+W            + E VA    + Q   +       R+  R    E  A+ Q  + 
Sbjct: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668

Query: 1749 NVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
                  +R +  G ++    AE        +    E    LLE    R+Q  AA+    R
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                      L  E  +   E   L AS A +     +  E+    L  +  +F+++A  
Sbjct: 1729 Q--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780

Query: 1862 LQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRF 1908
                 A  E+A+  +   +E +A  +A  +       A  G  T+L   A     +K   
Sbjct: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1840

Query: 1909 FSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGES 1968
                R L        R++E Q         E L +  +  ++E+E R K       L E 
Sbjct: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVED 1893

Query: 1969 LLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQ 2028
             L+++ Q  EEI   L+    +      + E    R+R   E    S++ +  EA   A+
Sbjct: 1894 TLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---AR 1949

Query: 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERP 2085
            +  LA+ +     ++ E++ K   A E++     +R AALE+   L+ K    R++ ER 
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERA 2006

Query: 2086 AEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
             +E+  Q    + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2007 EQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1240

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1241 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1298

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1299 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1358

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1359 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1477 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1527

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1702

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1703 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1758

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 1996

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2177 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2226

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2282

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2323

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2324 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2377

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2378 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2415

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2466

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2527 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2584 RAALAHS 2590



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1308

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1417

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1418 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1474 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1513

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1514 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1556

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1557 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1598

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1599 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1650 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1695 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1867

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2035

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2086

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2267 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2320

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2378

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2379 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2424

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2425 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2479

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEEL 2564



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1766

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1827 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1881

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1933

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1934 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1990

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 1991 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2044

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2045 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2160

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2161 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2211

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2212 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2269 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2438

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2439 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2492

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2549 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2594



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1978

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2034

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2035 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2089

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2144

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2145 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2186

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2187 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2303 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2471

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2532 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2590 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2650 LAQGHTTVDEL 2660



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1010 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1069

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1070 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1129

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1189

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1190 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1249

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1306

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1307 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1408

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1409 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1456

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1457 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1511

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1512 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1564

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1621

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1737

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1792

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1793 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1845

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1846 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2083

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2084 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2137

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2138 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2183 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2220

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2277

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2397

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2398 TELATQEKVT 2407


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  375 bits (964), Expect = e-103
 Identities = 534/2210 (24%), Positives = 912/2210 (41%), Gaps = 281/2210 (12%)

Query: 41   ERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML 100
            ER+ I+ +ADER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ L
Sbjct: 57   ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115

Query: 101  PKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQ 160
            P+  KG+MR H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI 
Sbjct: 116  PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174

Query: 161  DIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLI 220
            DI V  Q   E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LI
Sbjct: 175  DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232

Query: 221  DFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKM 280
            D +K+       NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++
Sbjct: 233  DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292

Query: 281  KVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQ 340
              +  +G R       A E +   ++Y  L   LL W+         R+F +S   ++  
Sbjct: 293  PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344

Query: 341  LQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLE 400
               F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L 
Sbjct: 345  WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
             A   RE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A    
Sbjct: 402  VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458

Query: 461  KKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNIL 507
             ++   +E D    +  +R L +  Q L K+  H Q             + +  R +  L
Sbjct: 459  PQRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 517

Query: 508  RL--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKH 559
            RL            Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  
Sbjct: 518  RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVD 574

Query: 560  LLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCF 619
            L  VE  L  H+ +   I     K++       +  EG+   P      +D +  L+  +
Sbjct: 575  LPSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQY 628

Query: 620  EELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH 679
             +L N +   KA+L   + L  F     +   W+ EKE+     D+    T++   +  +
Sbjct: 629  AKLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685

Query: 680  KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNL 739
             A   EL   +  ++++      ++       P +E+    +  QW  +  L    + +L
Sbjct: 686  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745

Query: 740  QDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEES 795
            ++   +FQF  D  + +  LQ     L       D  AT      L +  +D  E+L E 
Sbjct: 746  KENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804

Query: 796  RGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFG 855
            +G +  L ++A+   +     P   H ++    L    +A  D +Q        +     
Sbjct: 805  KGHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVH 850

Query: 856  ETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLV 915
            + D C+L +G  +                             K L +   G   A  S+ 
Sbjct: 851  KGDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVC 882

Query: 916  ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTK 975
                P ++E ++    L  + QA  TL              H   VD +    W      
Sbjct: 883  FLVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------ 923

Query: 976  VVESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK 1029
                 + L RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +
Sbjct: 924  -----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 978

Query: 1030 ----EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAV 1084
                 + G    H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V
Sbjct: 979  LMAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTV 1031

Query: 1085 ASEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLG 1140
                +P   E   E  Q + +    + E++G      R+    EKV+   +  P    L 
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR 1091

Query: 1141 QRLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP 1197
              LE        LG++ + RS +   L +        +  + AE +L   E  L   +  
Sbjct: 1092 SELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145

Query: 1198 DS----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIK 1246
             +    LEA +A ++K     E    + +  RD++    + G +L     E ++  ++ +
Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205

Query: 1247 EKVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS- 1301
            E+V  + +R +    + + + +E   L R   +L+ + ++   L  W+ D     + +  
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQA 1262

Query: 1302 --YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALH 1358
                +++ +  +  + QA + E+  H   +E      KQ ++  K     LV+ K +   
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1320

Query: 1359 RLWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKD 1410
                E  A+  +K +  S + S     + L+TH        +++I  + + LR  +  + 
Sbjct: 1321 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376

Query: 1411 LTSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
            L    R   + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRR 1431

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
             +  +++ + K  I  +L        ++L  +  A+     +  +   +    ++ EI  
Sbjct: 1432 EEAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483

Query: 1530 HTPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEA 1586
               ++E    QRG  +  ++A     ++ E +    Q   +RLR       QR R A   
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR 1646
                + A EAEA   +Q      +E+    E A    +R LRQ  A  +  R ++     
Sbjct: 1544 LASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALET 1596

Query: 1647 AQ-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD- 1700
            AQ      L S      E+  +L+  + + +  +  + EE +R+ +      + + E + 
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656

Query: 1701 DLEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERV 1747
            +LE+W            + E VA    + Q   +       R+  R    E  A+ Q  +
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716

Query: 1748 DNVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLH 1800
                   +R +  G ++    AE        +    E    LLE    R+Q  AA+    
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776

Query: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
            R          L  E  +   E   L AS A +     +  E+    L  +  +F+++A 
Sbjct: 1777 RQ--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828

Query: 1861 RLQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFR 1907
                  A  E+A+  +   +E +A  +A  +       A  G  T+L   A     +K  
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888

Query: 1908 FFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGE 1967
                 R L        R++E Q         E L +  +  ++E+E R K       L E
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVE 1941

Query: 1968 SLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
              L+++ Q  EEI   L+    +      + E    R+R   E    S++ +  EA   A
Sbjct: 1942 DTLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---A 1997

Query: 2028 QEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAER 2084
            ++  LA+ +     ++ E++ K   A E++     +R AALE+   L+ K    R++ ER
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRER 2054

Query: 2085 PAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
              +E+  Q    + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2055 AEQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1289

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1290 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1347

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1348 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1407

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1408 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1526 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1576

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1751

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1752 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1807

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2045

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2226 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2275

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2331

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2372

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2373 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2426

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2427 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2464

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2515

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2576 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2633 RAALAHS 2639



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1357

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1466

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1467 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1523 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1562

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1563 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1605

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1606 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1647

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1648 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1699 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1744 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1916

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2084

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2135

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2316 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2369

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2427

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2428 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2473

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2474 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2528

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEEL 2613



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1815

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1876 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1930

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1982

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1983 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2039

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 2040 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2093

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2094 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2209

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2210 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2260

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2261 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2318 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2487

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2488 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2541

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2598 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2643



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2027

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2083

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2084 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2138

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2193

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2194 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2235

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2236 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2352 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2520

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2581 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2639 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2699 LAQGHTTVDEL 2709



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1059 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1118

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1119 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1178

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1238

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1239 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1298

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1355

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1356 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1457

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1458 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1505

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1506 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1560

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1561 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1613

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1670

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1786

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1841

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1842 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1894

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1895 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2132

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2133 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2186

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2187 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2232 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2269

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2326

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2387 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2446

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2447 TELATQEKVT 2456


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  374 bits (961), Expect = e-103
 Identities = 531/2206 (24%), Positives = 908/2206 (41%), Gaps = 280/2206 (12%)

Query: 45   IKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPT 104
            +K + DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  
Sbjct: 1    MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE- 59

Query: 105  KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVV 164
            KG+MR H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V
Sbjct: 60   KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119

Query: 165  QTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDK 224
              Q   E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K
Sbjct: 120  SGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNK 177

Query: 225  LKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLA 284
            +       NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  + 
Sbjct: 178  VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 237

Query: 285  VEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAF 344
             +G R       A E +   ++Y  L   LL W+         R+F +S   ++     F
Sbjct: 238  -DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQF 289

Query: 345  STYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEY 404
              ++ +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A  
Sbjct: 290  LKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAIL 346

Query: 405  RRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKH 464
             RE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A     ++ 
Sbjct: 347  EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRA 403

Query: 465  EAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL-- 509
              +E D    +  +R L +  Q L K+  H Q             + +  R +  LRL  
Sbjct: 404  GEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 462

Query: 510  ------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
                      Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  V
Sbjct: 463  GVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSV 519

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            E  L  H+ +   I     K++       +  EG+   P      +D +  L+  + +L 
Sbjct: 520  EAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLL 573

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
            N +   KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A  
Sbjct: 574  NSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 630

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743
             EL   +  ++++      ++       P +E+    +  QW  +  L    + +L++  
Sbjct: 631  RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 690

Query: 744  NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVM 799
             +FQF  D  + +  LQ     L       D  AT      L +  +D  E+L E +G +
Sbjct: 691  AYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHL 749

Query: 800  EHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDA 859
              L ++A+   +     P   H ++    L    +A  D +Q        +     + D 
Sbjct: 750  SGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDE 795

Query: 860  CELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGH 919
            C+L +G  +                             K L +   G   A  S+     
Sbjct: 796  CQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVP 827

Query: 920  PRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES 979
            P ++E ++    L  + QA  TL              H   VD +    W          
Sbjct: 828  PPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW---------- 864

Query: 980  TKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK---- 1029
             + L RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +    
Sbjct: 865  -QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 923

Query: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASED 1088
             + G    H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    
Sbjct: 924  REYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLR 976

Query: 1089 MP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLE 1144
            +P   E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE
Sbjct: 977  LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1036

Query: 1145 GLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS-- 1199
                    LG++ + RS +   L +        +  + AE +L   E  L   +   +  
Sbjct: 1037 ------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090

Query: 1200 --LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQ 1250
              LEA +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V 
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150

Query: 1251 LIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YD 1303
             + +R +    + + + +E   L R   +L+ + ++   L  W+ D     + +      
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207

Query: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWD 1362
            +++ +  +  + QA + E+  H   +E      KQ ++  K     LV+ K +       
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------ 1261

Query: 1363 ELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSV 1414
            E  A+  +K +  S + S     + L+TH        +++I  + + LR  +  + L   
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1321

Query: 1415 NRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
             R   + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R +  
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAA 1376

Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
            +++ + K  I  +L        ++L  +  A+     +  +   +    ++ EI     +
Sbjct: 1377 VDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428

Query: 1534 VEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYY 1590
            +E    QRG  +  ++A     ++ E +    Q   +RLR       QR R A       
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488

Query: 1591 LDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-- 1648
            + A EAEA   +Q      +E+    E A    +R LRQ  A  +  R ++     AQ  
Sbjct: 1489 VKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRS 1541

Query: 1649 ---GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQ 1704
                L S      E+  +L+  + + +  +  + EE +R+ +      + + E + +LE+
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601

Query: 1705 W----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751
            W            + E VA    + Q   +       R+  R    E  A+ Q  +    
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661

Query: 1752 AFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804
               +R +  G ++    AE        +    E    LLE    R+Q  AA+    R   
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1719

Query: 1805 TGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT 1864
                   L  E  +   E   L AS A +     +  E+    L  +  +F+++A     
Sbjct: 1720 ------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773

Query: 1865 AYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSM 1911
              A  E+A+  +   +E +A  +A  +       A  G  T+L   A     +K      
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833

Query: 1912 ARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
             R L        R++E Q         E L +  +  ++E+E R K       L E  L+
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLR 1886

Query: 1972 RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPY 2031
            ++ Q  EEI   L+    +      + E    R+R   E    S++ +  EA   A++  
Sbjct: 1887 QRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQ 1942

Query: 2032 LASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEE 2088
            LA+ +     ++ E++ K   A E++     +R AALE+   L+ K    R++ ER  +E
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQE 1999

Query: 2089 TGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
            +  Q    + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2000 SARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1119 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1178

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1230

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1231 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1288

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1289 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1348

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1349 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1407 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1466

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1467 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1517

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1577

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1692

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1693 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1748

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 1986

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2167 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2216

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2272

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2313

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2314 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2367

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2368 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2405

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2456

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2457 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2517 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2574 RAALAHS 2580



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1298

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1358

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1359 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1407

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1408 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1463

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1464 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1503

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1504 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1546

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1547 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1588

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1589 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1640 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1684

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1685 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1857

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2025

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2076

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2196

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2256

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2257 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2310

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2368

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2369 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2414

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2415 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2469

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEEL 2554



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1756

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1817 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1871

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1923

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1924 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1980

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 1981 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2034

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2035 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2150

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2151 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2201

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2202 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2259 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2428

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2429 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2482

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2539 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2584



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1968

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2024

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2025 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2079

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2134

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2135 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2176

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2177 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2293 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2461

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2522 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2579

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2580 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2639

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2640 LAQGHTTVDEL 2650



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1000 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1059

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1060 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1119

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1120 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1179

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1180 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1239

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1296

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1297 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1398

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1399 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1446

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1447 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1501

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1502 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1554

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1611

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1672 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1727

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1782

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1783 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1835

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1836 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2013

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2073

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2074 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2127

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2128 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2173 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2210

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2267

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2387

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2388 TELATQEKVT 2397


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  373 bits (958), Expect = e-103
 Identities = 534/2221 (24%), Positives = 913/2221 (41%), Gaps = 281/2221 (12%)

Query: 30   LDNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLI 89
            L ++    + +E  R K   DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI
Sbjct: 5    LPDEQDFIQAYEEVREK-YKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLI 63

Query: 90   KLLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGL 149
             LLEVLSG+ LP+  KG+MR H L+NV  AL +L+ ++V L N+ + DI DGN +L LGL
Sbjct: 64   SLLEVLSGDSLPRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGL 122

Query: 150  IWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFN 209
            IWTIIL FQI DI V  Q   E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FN
Sbjct: 123  IWTIILHFQISDIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFN 180

Query: 210  ALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITY 269
            A+IH+H+P LID +K+       NL+ AF+VAER LG+  LLDPEDV    PDEKSIITY
Sbjct: 181  AIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITY 240

Query: 270  VVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRK 329
            V + Y    ++  +  +G R       A E +   ++Y  L   LL W+         R+
Sbjct: 241  VSSLYDAMPRVPDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERR 292

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
            F +S   ++     F  ++ +E P K  +K   + +  +++  ++A   KV     G   
Sbjct: 293  FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHP 349

Query: 390  SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
             D+ + W  L  A   RE  LR+E  R E L+++  +   +A + E  L++   L+  D 
Sbjct: 350  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD- 408

Query: 450  FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ------------- 496
                L A     ++   +E D    +  +R L +  Q L K+  H Q             
Sbjct: 409  --VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHE 465

Query: 497  KRITARKDNILRL--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIK 548
            + +  R +  LRL            Q  LQS ++R E   +  +  QD+L    W++E +
Sbjct: 466  RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQ 522

Query: 549  AHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVI 608
              +  AE+G  L  VE  L  H+ +   I     K++       +  EG+   P      
Sbjct: 523  HRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAY 576

Query: 609  QDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKD 668
            +D +  L+  + +L N +   KA+L   + L  F     +   W+ EKE+     D+   
Sbjct: 577  RDCLGRLDLQYAKLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 633

Query: 669  LTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQL 728
             T++   +  + A   EL   +  ++++      ++       P +E+    +  QW  +
Sbjct: 634  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 693

Query: 729  KDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKK 784
              L    + +L++   +FQF  D  + +  LQ     L       D  AT      L + 
Sbjct: 694  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQD 752

Query: 785  HKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRL 844
             +D  E+L E +G +  L ++A+   +     P   H ++    L    +A  D +Q   
Sbjct: 753  AQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--- 803

Query: 845  QEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQI 904
                 +     + D C+L +G  +                             K L +  
Sbjct: 804  -----VEVTVHKGDECQL-VGPAQ-------------------------PSHWKVLSS-- 830

Query: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
             G   A  S+     P ++E ++    L  + QA  TL              H   VD +
Sbjct: 831  SGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMK 877

Query: 965  ETSKWITDKTKVVESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERES 1018
                W           + L RD+  I    +A  R L   E+  A  +++    A  R+S
Sbjct: 878  SLLAW-----------QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDS 926

Query: 1019 QQLMDSHPEQK----EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQ 1074
            Q      PE +     + G    H ++L Q L+Q  Q       E S+ Q  + +L D +
Sbjct: 927  QDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIR 979

Query: 1075 AWLSITQ-KAVASEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ- 1129
              L   + + V    +P   E   E  Q + +    + E++G      R+    EKV+  
Sbjct: 980  LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1039

Query: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSN 1186
             +  P    L   LE        LG++ + RS +   L +        +  + AE +L  
Sbjct: 1040 PEPSPAAPTLRSELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093

Query: 1187 QEYTLAHLEPPDS----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV--- 1235
             E  L   +   +    LEA +A ++K     E    + +  RD++    + G +L    
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153

Query: 1236 AEGNLYSDKIKEKVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWIN 1291
             E ++  ++ +E+V  + +R +    + + + +E   L R   +L+ + ++   L  W+ 
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQ 1210

Query: 1292 DKLLTSQDVS---YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFT 1347
            D     + +      +++ +  +  + QA + E+  H   +E      KQ ++  K    
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1270

Query: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAME 1399
             LV+ K +       E  A+  +K +  S + S     + L+TH        +++I  + 
Sbjct: 1271 QLVTYKAQL------EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324

Query: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEK 1458
            + LR  +  + L    R   + +  E +  + K+ +L E  AQ  +  E        +++
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQ 1381

Query: 1459 RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMK 1518
            R  +  E + R +  +++ + K  I  +L        ++L  +  A+     +  +   +
Sbjct: 1382 RMQE--EVVRREEAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAER 1431

Query: 1519 KNQTLQNEILGHTPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAG 1575
                ++ EI     ++E    QRG  +  ++A     ++ E +    Q   +RLR     
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1491

Query: 1576 RLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVED 1635
              QR R A       + A EAEA   +Q      +E+    E A    +R LRQ  A  +
Sbjct: 1492 ESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVE 1544

Query: 1636 YGRNIKQLASRAQ-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMY 1690
              R ++     AQ      L S      E+  +L+  + + +  +  + EE +R+ +   
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604

Query: 1691 HLFQLKRETD-DLEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFA 1736
               + + E + +LE+W            + E VA    + Q   +       R+  R   
Sbjct: 1605 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664

Query: 1737 RETGAIGQERVDNVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTR 1789
             E  A+ Q  +       +R +  G ++    AE        +    E    LLE    R
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724

Query: 1790 MQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLG 1849
            +Q  AA+    R          L  E  +   E   L AS A +     +  E+    L 
Sbjct: 1725 LQREAAAATQKRQ--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776

Query: 1850 VQVQQFQDVATRLQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVD 1901
             +  +F+++A       A  E+A+  +   +E +A  +A  +       A  G  T+L  
Sbjct: 1777 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836

Query: 1902 TA-----DKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRS 1956
             A     +K       R L        R++E Q         E L +  +  ++E+E R 
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQ 1895

Query: 1957 KNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
            K       L E  L+++ Q  EEI   L+    +      + E    R+R   E    S+
Sbjct: 1896 KG------LVEDTLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948

Query: 2017 DASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLEL 2076
            + +  EA   A++  LA+ +     ++ E++ K   A E++     +R AALE+   L+ 
Sbjct: 1949 EQAELEA---ARQRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKA 2002

Query: 2077 K---ERQIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEP 2133
            K    R++ ER  +E+  Q    + A EA      A E+    ++  +     ++LQ E 
Sbjct: 2003 KVEEARRLRERAEQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059

Query: 2134 S 2134
            S
Sbjct: 2060 S 2060



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1137 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1196

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1248

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1249 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1306

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1307 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1366

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1367 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1425 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1484

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1485 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1535

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1595

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1710

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1711 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1766

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2004

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2185 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2234

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2290

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2291 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2331

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2332 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2385

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2386 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2423

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2474

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2475 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2535 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2592 RAALAHS 2598



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1258 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1316

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1376

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1377 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1425

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1426 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1481

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1482 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1521

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1522 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1564

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1565 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1606

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1607 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1658 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1702

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1703 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1875

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2043

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2094

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2214

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2274

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2275 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2328

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2386

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2387 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2432

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2433 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2487

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEEL 2572



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1774

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1835 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1889

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1941

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1942 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1998

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 1999 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2052

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2053 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2168

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2169 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2219

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2220 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2277 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2446

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2447 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2500

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2557 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2602



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1986

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2042

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2043 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2097

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2152

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2153 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2194

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2195 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2311 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2423

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2479

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2540 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2597

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2598 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2657

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2658 LAQGHTTVDEL 2668



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1018 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1077

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1078 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1137

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1138 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1197

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1198 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1257

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1258 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1314

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1315 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1416

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1417 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1464

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1465 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1519

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1520 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1572

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1629

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1690 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1745

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1800

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1801 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1853

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1854 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2031

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2091

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2092 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2145

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2146 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2191 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2228

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2285

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2405

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2406 TELATQEKVT 2415


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  372 bits (956), Expect = e-102
 Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)

Query: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
            DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 38   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96

Query: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 97   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155

Query: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 156  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214

Query: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 215  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273

Query: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 274  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326

Query: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 327  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383

Query: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
            LR+E  R E L+++  +   +A + E  L++   L+  D     L A     ++   +E 
Sbjct: 384  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440

Query: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 441  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 499

Query: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 500  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 556

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 557  SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 608

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 609  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 668  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
              D  + +  LQ     L       D  AT      L +  +D  E+L E +G +  L +
Sbjct: 728  FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786

Query: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 787  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 831

Query: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 832  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 864

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
             ++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 865  AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 900

Query: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 901  RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 960

Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 961  CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013

Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1068

Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1069 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127

Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187

Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
             +    + + + +E   L R   +L+ + ++   L  W+ D     + +      +++ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244

Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
              +  + QA + E+  H   +E      KQ ++  K     LV+ K +       E  A+
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1298

Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
              +K +  S + S     + L+TH        +++I  + + LR  +  + L    R   
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358

Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
            + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R +  +++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1413

Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
             K  I  +L        ++L  +  A+     +  +   +    ++ EI     ++E   
Sbjct: 1414 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465

Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
             QRG  +  ++A     ++ E +    Q   +RLR       QR R A       + A E
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1524

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
            AEA   +Q      +E+    E A    +R LRQ  A  +  R ++     AQ      L
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1578

Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
             S      E+  +L+  + + +  +  + EE +R+ +      + + E + +LE+W    
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638

Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
                    + E VA    + Q   +       R+  R    E  A+ Q  +       +R
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
             +  G ++    AE        +    E    LLE    R+Q  AA+    R        
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1751

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
              L  E  +   E   L AS A +     +  E+    L  +  +F+++A       A  
Sbjct: 1752 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810

Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
            E+A+  +   +E +A  +A  +       A  G  T+L   A     +K       R L 
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870

Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
                   R++E Q         E L +  +  ++E+E R K       L E  L+++ Q 
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 1923

Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
             EEI   L+    +      + E    R+R   E    S++ +  EA   A++  LA+ +
Sbjct: 1924 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 1979

Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
                 ++ E++ K   A E++     +R AALE+   L+ K    R++ ER  +E+  Q 
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036

Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
               + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2037 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1262

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1263 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1320

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1380

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1381 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1499 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1549

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1724

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1725 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1780

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2018

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2199 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2248

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2304

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2345

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2346 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2399

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2400 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2437

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2488

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2549 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2606 RAALAHS 2612



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1330

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1439

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1440 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1535

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1536 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1578

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1579 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1620

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1621 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1672 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1717 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1889

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2057

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2108

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2289 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2342

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2400

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2401 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2446

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2447 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2501

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEEL 2586



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1788

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1849 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1903

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1955

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1956 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2012

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 2013 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2066

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2182

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2183 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2234 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2291 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2460

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2461 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2571 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2616



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2000

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2056

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2057 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2111

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2166

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2167 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2208

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2209 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2325 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2493

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2554 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2612 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2672 LAQGHTTVDEL 2682



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1091

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1092 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1211

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1271

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1328

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1329 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1430

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1431 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1478

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1479 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1533

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1534 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1643

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1759

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1814

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1815 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1867

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1868 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2106 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2159

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2160 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2205 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2242

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2299

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2420 TELATQEKVT 2429


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  372 bits (956), Expect = e-102
 Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)

Query: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
            DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 42   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 100

Query: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 101  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 159

Query: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 160  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 218

Query: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 219  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 277

Query: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 278  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 330

Query: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 331  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 387

Query: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
            LR+E  R E L+++  +   +A + E  L++   L+  D     L A     ++   +E 
Sbjct: 388  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 444

Query: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 445  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 503

Query: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 504  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 560

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 561  SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 612

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 613  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 671

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 672  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 731

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
              D  + +  LQ     L       D  AT      L +  +D  E+L E +G +  L +
Sbjct: 732  FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 790

Query: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 791  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 835

Query: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 836  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 868

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
             ++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 869  AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 904

Query: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 905  RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 964

Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 965  CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017

Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1072

Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1073 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1131

Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1132 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191

Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
             +    + + + +E   L R   +L+ + ++   L  W+ D     + +      +++ +
Sbjct: 1192 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248

Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
              +  + QA + E+  H   +E      KQ ++  K     LV+ K +       E  A+
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1302

Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
              +K +  S + S     + L+TH        +++I  + + LR  +  + L    R   
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362

Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
            + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R +  +++ +
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1417

Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
             K  I  +L        ++L  +  A+     +  +   +    ++ EI     ++E   
Sbjct: 1418 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1469

Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
             QRG  +  ++A     ++ E +    Q   +RLR       QR R A       + A E
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1528

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
            AEA   +Q      +E+    E A    +R LRQ  A  +  R ++     AQ      L
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1582

Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
             S      E+  +L+  + + +  +  + EE +R+ +      + + E + +LE+W    
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642

Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
                    + E VA    + Q   +       R+  R    E  A+ Q  +       +R
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702

Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
             +  G ++    AE        +    E    LLE    R+Q  AA+    R        
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1755

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
              L  E  +   E   L AS A +     +  E+    L  +  +F+++A       A  
Sbjct: 1756 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814

Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
            E+A+  +   +E +A  +A  +       A  G  T+L   A     +K       R L 
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874

Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
                   R++E Q         E L +  +  ++E+E R K       L E  L+++ Q 
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 1927

Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
             EEI   L+    +      + E    R+R   E    S++ +  EA   A++  LA+ +
Sbjct: 1928 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 1983

Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
                 ++ E++ K   A E++     +R AALE+   L+ K    R++ ER  +E+  Q 
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040

Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
               + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2041 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1155 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1214

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1266

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1267 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1324

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1325 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1384

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1385 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1443 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1502

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1503 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1553

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1613

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1728

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1729 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1784

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2022

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2203 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2252

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2308

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2349

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2350 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2403

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2404 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2441

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2492

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2493 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2553 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2610 RAALAHS 2616



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1334

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1394

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1395 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1443

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1444 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1499

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1500 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1539

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1540 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1582

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1583 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1624

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1625 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1676 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1720

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1721 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1893

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2061

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2112

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2232

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2292

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2293 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2346

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2404

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2405 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2450

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2451 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2505

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEEL 2590



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1792

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1853 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1907

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1959

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1960 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2016

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 2017 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2070

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2071 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2186

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2187 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2237

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2238 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2295 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2464

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2465 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2518

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2575 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2620



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2004

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2060

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2061 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2115

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2170

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2171 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2212

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2213 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2329 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2497

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2558 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2615

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2616 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2676 LAQGHTTVDEL 2686



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1036 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1095

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1096 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1155

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1156 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1215

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1216 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1275

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1332

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1333 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1434

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1435 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1482

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1483 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1537

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1538 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1590

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1647

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1708 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1763

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1818

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1819 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1871

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1872 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2049

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2109

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2110 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2163

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2164 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2209 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2246

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2303

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2423

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2424 TELATQEKVT 2433


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  372 bits (956), Expect = e-102
 Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)

Query: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
            DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 38   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96

Query: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 97   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155

Query: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 156  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214

Query: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 215  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273

Query: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 274  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326

Query: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 327  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383

Query: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
            LR+E  R E L+++  +   +A + E  L++   L+  D     L A     ++   +E 
Sbjct: 384  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440

Query: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 441  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 499

Query: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 500  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 556

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 557  SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 608

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 609  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 668  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
              D  + +  LQ     L       D  AT      L +  +D  E+L E +G +  L +
Sbjct: 728  FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786

Query: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 787  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 831

Query: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 832  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 864

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
             ++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 865  AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 900

Query: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 901  RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 960

Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 961  CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013

Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1068

Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1069 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127

Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187

Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
             +    + + + +E   L R   +L+ + ++   L  W+ D     + +      +++ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244

Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
              +  + QA + E+  H   +E      KQ ++  K     LV+ K +       E  A+
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1298

Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
              +K +  S + S     + L+TH        +++I  + + LR  +  + L    R   
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358

Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
            + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R +  +++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1413

Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
             K  I  +L        ++L  +  A+     +  +   +    ++ EI     ++E   
Sbjct: 1414 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465

Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
             QRG  +  ++A     ++ E +    Q   +RLR       QR R A       + A E
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1524

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
            AEA   +Q      +E+    E A    +R LRQ  A  +  R ++     AQ      L
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1578

Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
             S      E+  +L+  + + +  +  + EE +R+ +      + + E + +LE+W    
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638

Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
                    + E VA    + Q   +       R+  R    E  A+ Q  +       +R
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
             +  G ++    AE        +    E    LLE    R+Q  AA+    R        
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1751

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
              L  E  +   E   L AS A +     +  E+    L  +  +F+++A       A  
Sbjct: 1752 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810

Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
            E+A+  +   +E +A  +A  +       A  G  T+L   A     +K       R L 
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870

Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
                   R++E Q         E L +  +  ++E+E R K       L E  L+++ Q 
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 1923

Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
             EEI   L+    +      + E    R+R   E    S++ +  EA   A++  LA+ +
Sbjct: 1924 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 1979

Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
                 ++ E++ K   A E++     +R AALE+   L+ K    R++ ER  +E+  Q 
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036

Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
               + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2037 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1262

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1263 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1320

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1380

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1381 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1499 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1549

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1724

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1725 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1780

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2018

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2199 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2248

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2304

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2345

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2346 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2399

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2400 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2437

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2488

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2549 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2606 RAALAHS 2612



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1330

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1439

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1440 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1535

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1536 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1578

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1579 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1620

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1621 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1672 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1717 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1889

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2057

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2108

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2289 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2342

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2400

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2401 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2446

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2447 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2501

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEEL 2586



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1788

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1849 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1903

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1955

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 1956 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2012

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 2013 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2066

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2182

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2183 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2234 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2291 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2460

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2461 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2514

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2571 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2616



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2000

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2056

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2057 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2111

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2166

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2167 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2208

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2209 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2325 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2493

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2554 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2612 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2672 LAQGHTTVDEL 2682



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1091

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1092 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1211

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1271

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1328

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1329 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1430

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1431 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1478

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1479 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1533

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1534 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1643

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1759

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1814

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1815 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1867

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1868 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2106 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2159

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2160 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2205 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2242

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2299

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2420 TELATQEKVT 2429


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  372 bits (956), Expect = e-102
 Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)

Query: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
            DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 175  DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233

Query: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 234  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292

Query: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 293  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351

Query: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 352  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410

Query: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 411  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463

Query: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 464  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520

Query: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
            LR+E  R E L+++  +   +A + E  L++   L+  D     L A     ++   +E 
Sbjct: 521  LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577

Query: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 578  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 636

Query: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 637  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 693

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 694  SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 745

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 746  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 805  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
              D  + +  LQ     L       D  AT      L +  +D  E+L E +G +  L +
Sbjct: 865  FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923

Query: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 924  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 968

Query: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 969  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 1001

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
             ++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 1002 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1037

Query: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 1038 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1097

Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 1098 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150

Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1205

Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1206 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264

Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324

Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
             +    + + + +E   L R   +L+ + ++   L  W+ D     + +      +++ +
Sbjct: 1325 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381

Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
              +  + QA + E+  H   +E      KQ ++  K     LV+ K +       E  A+
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1435

Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
              +K +  S + S     + L+TH        +++I  + + LR  +  + L    R   
Sbjct: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495

Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
            + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R +  +++ +
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1550

Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
             K  I  +L        ++L  +  A+     +  +   +    ++ EI     ++E   
Sbjct: 1551 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602

Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
             QRG  +  ++A     ++ E +    Q   +RLR       QR R A       + A E
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1661

Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
            AEA   +Q      +E+    E A    +R LRQ  A  +  R ++     AQ      L
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1715

Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
             S      E+  +L+  + + +  +  + EE +R+ +      + + E + +LE+W    
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775

Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
                    + E VA    + Q   +       R+  R    E  A+ Q  +       +R
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835

Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
             +  G ++    AE        +    E    LLE    R+Q  AA+    R        
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1888

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
              L  E  +   E   L AS A +     +  E+    L  +  +F+++A       A  
Sbjct: 1889 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947

Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
            E+A+  +   +E +A  +A  +       A  G  T+L   A     +K       R L 
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007

Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
                   R++E Q         E L +  +  ++E+E R K       L E  L+++ Q 
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 2060

Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
             EEI   L+    +      + E    R+R   E    S++ +  EA   A++  LA+ +
Sbjct: 2061 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 2116

Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
                 ++ E++ K   A E++     +R AALE+   L+ K    R++ ER  +E+  Q 
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173

Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
               + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2174 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211



 Score =  101 bits (251), Expect = 9e-21
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347

Query: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1399

Query: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 1400 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1457

Query: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 1458 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1517

Query: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 1518 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575

Query: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635

Query: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 1636 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1686

Query: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746

Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806

Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1861

Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1862 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1917

Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977

Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037

Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097

Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2155

Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215

Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275

Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335

Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 2336 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2385

Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2441

Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2482

Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 2483 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2536

Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 2537 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2574

Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2625

Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685

Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 2686 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742

Query: 2017 DASVAEA 2023
             A++A +
Sbjct: 2743 RAALAHS 2749



 Score = 78.2 bits (191), Expect = 8e-14
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1467

Query: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527

Query: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1576

Query: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 1577 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632

Query: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 1633 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1672

Query: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 1673 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1715

Query: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 1716 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1757

Query: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 1758 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808

Query: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 1809 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853

Query: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 1854 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908

Query: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968

Query: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 2026

Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086

Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146

Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2194

Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2245

Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305

Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365

Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425

Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 2426 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2479

Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2537

Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 2538 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2583

Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 2584 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2638

Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698

Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
              E  +RK E +  L Q +R+ ++L
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEEL 2723



 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868

Query: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1925

Query: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 1986 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 2040

Query: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 2092

Query: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 2093 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2149

Query: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 2150 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2203

Query: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 2204 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260

Query: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2319

Query: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 2320 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2370

Query: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 2371 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427

Query: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 2428 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480

Query: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540

Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2597

Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 2598 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2651

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 2708 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2753



 Score = 75.1 bits (183), Expect = 7e-13
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2137

Query: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2193

Query: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 2194 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2248

Query: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2303

Query: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 2304 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2345

Query: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 2346 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401

Query: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461

Query: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 2462 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574

Query: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2630

Query: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690

Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 2691 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748

Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 2749 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808

Query: 1127 VIQGQTDPEYL 1137
            + QG T  + L
Sbjct: 2809 LAQGHTTVDEL 2819



 Score = 74.3 bits (181), Expect = 1e-12
 Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)

Query: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 1169 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1228

Query: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 1229 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1288

Query: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1348

Query: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 1349 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1408

Query: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1465

Query: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 1466 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512

Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1567

Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1568 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1615

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1616 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1670

Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1671 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1723

Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1780

Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1896

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1951

Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1952 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 2004

Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 2005 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062

Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122

Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
               R Q  L+A            E++ RL+ +V++                 L   A ++
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182

Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
            + + E   H F ++++  +L+Q + +++ V        +         ++ R  A    A
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2242

Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
              + +V+      ERL  +   +A   A+ +    ++  +  +    R Q   A+  L +
Sbjct: 2243 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2296

Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
                 AE+     EKH++           AE   R     E+EL  L +Q+++       
Sbjct: 2297 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L       KAEA +                 A +R+Q+ +       FS+ R  +  +  
Sbjct: 2342 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2379

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
            +  +IE + R   +   +   ++ Q   AE   +    +A L +      R  Q +EE  
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2436

Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
            +  QQ     K + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +     
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496

Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
                 ++ ++     +   ++ AER     A + +      ++ Q   + AEE G +   
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2556

Query: 2096 GETAGEAPVS 2105
             E A +  V+
Sbjct: 2557 TELATQEKVT 2566


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  337 bits (865), Expect = 6e-92
 Identities = 348/1301 (26%), Positives = 564/1301 (43%), Gaps = 171/1301 (13%)

Query: 50   DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
            DER+ VQKKT TKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP+  KG+MR
Sbjct: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229

Query: 110  IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
             H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  Q  
Sbjct: 230  FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288

Query: 170  RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
             E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID +K+    
Sbjct: 289  -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347

Query: 230  ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
               NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++  +  +G R
Sbjct: 348  NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406

Query: 290  VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
                   A E +   ++Y  L   LL W+         R+F +S   ++     F  ++ 
Sbjct: 407  -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459

Query: 350  VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
            +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  A   RE  
Sbjct: 460  MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516

Query: 410  LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
            LR+E  R E L+++  +   +A + E  L +   L+  D     L A     ++   +E 
Sbjct: 517  LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573

Query: 470  DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
            D    +  +R L +  Q L K+  H Q             + +  R +  LRL       
Sbjct: 574  DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632

Query: 510  -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
                 Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L  VE  L 
Sbjct: 633  ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 689

Query: 569  KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
             H+ +   I     K++       +  EG+   P      +D +  L+  + +L N +  
Sbjct: 690  SHRGLHQSIEEFQAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 741

Query: 629  RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
             KA+L   + L  F     +   W+ EKE+     D+    T++   +  + A   EL  
Sbjct: 742  -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800

Query: 689  LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
             +  ++++      ++       P +E+    +  QW  +  L    + +L++   +FQF
Sbjct: 801  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860

Query: 749  QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
              D  + +  LQ     L  ++   D  AT      L +  +D  E+L E +G +  L +
Sbjct: 861  FSDVREAEGQLQKLQEALRRKN-SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 919

Query: 805  QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
            +A+   +     P   H ++    L    +A  D +Q        +     + D C+L +
Sbjct: 920  RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 964

Query: 865  GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
            G  +                             K L +   G   A  S+     P ++E
Sbjct: 965  GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 997

Query: 925  VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
            V++    L  + QA  TL              H   VD +    W           + L 
Sbjct: 998  VQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1033

Query: 985  RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
            RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE +     + G 
Sbjct: 1034 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1093

Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
               H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V    +P   
Sbjct: 1094 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1146

Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
            E   E  Q + +    + E++G      R+    EKV+   +  P    L   LE     
Sbjct: 1147 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1201

Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
               LG++ + RS +   L +        +  + AE +L   E  L   +   +    LEA
Sbjct: 1202 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260

Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
             +A ++K     E    + +  RD++    + G +L     E ++  ++ +E+V  + +R
Sbjct: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320

Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWIND 1292
             +    + + + +E   L R   +L+ + ++   L  W+ D
Sbjct: 1321 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQD 1358



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 88/440 (20%), Positives = 175/440 (39%), Gaps = 42/440 (9%)

Query: 1562 LQSSWDRLREAAAGRLQRLR---DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEE- 1617
            ++  W +L  A   R ++LR   +  E  Q  +   + EA + E++L+     +  D   
Sbjct: 499  VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL 558

Query: 1618 -GAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLK 1676
              A  + +R    +R ++     I+ L +  Q L    HP+GEQ+ R   ++ +    ++
Sbjct: 559  LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 618

Query: 1677 DVAEERKRK-------------LENMYHLFQLKRET----DDLEQWISEKELVASSPEMG 1719
                 R +              L+++    +L+  T     DL  W+ E +      E G
Sbjct: 619  TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWG 678

Query: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEM 1778
             D   V       R           + ++   A IER   D G    AT   ++D L  +
Sbjct: 679  VDLPSVEAQLGSHRGL--------HQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL 730

Query: 1779 WADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDAS----TAESF 1834
                 +L+++    L +   LH +     + L  ++EK     E+VG D S       + 
Sbjct: 731  DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWSDRNTNMTAK 787

Query: 1835 HRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAG 1894
               ++A  REL L   ++++ Q+   RL       +   +++ +  +   W  +L  C  
Sbjct: 788  KESYSALMRELELKEKKIKELQNAGDRLLREDHPAR-PTVESFQAALQTQWSWMLQLCCC 846

Query: 1895 RRTQLVDTADKFRFFSMARDL---LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951
                L + A  F+FFS  R+    L  ++  +R+  + +R   V+ +E L++  Q    +
Sbjct: 847  IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQ 906

Query: 1952 IETRSKNFSACLELGESLLQ 1971
            +     + S   +  ++++Q
Sbjct: 907  LNEYKGHLSGLAKRAKAVVQ 926



 Score = 49.3 bits (116), Expect = 4e-05
 Identities = 196/982 (19%), Positives = 359/982 (36%), Gaps = 180/982 (18%)

Query: 701  HGMVARKQFG--HPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAW 758
            H +   K++G  H  I  R K++ +++++L+ L     K   +A    +    AD L   
Sbjct: 495  HPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADAL--- 551

Query: 759  LQDAHRLLSGEDVGQDEGAT-RALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSP 817
            LQ   RLL+   V Q  G   R L K          + + + +    Q +   + +R   
Sbjct: 552  LQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGE---QMYRRVY 608

Query: 818  DVTHRLQALRELYQ-----------QVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
             +  RL A+R  Y              VAQ  L+  + +  L+  T+    D    W+ E
Sbjct: 609  RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-WVEE 667

Query: 867  KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
             +  +   E    L  +E        L Q ++    +I+        L     P +R   
Sbjct: 668  NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL----SPATRGA- 722

Query: 927  QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
             Y+D L      +  L++  +  + S   +H++     +   W+ +K +  E   D    
Sbjct: 723  -YRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDR 780

Query: 987  LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
               + A +   S L R++   + ++  L+    +L+      +  +   Q  L+  W  +
Sbjct: 781  NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840

Query: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASE---DMPESLPEAEQLLQQH 1103
             Q     E  L E +    F  D+ + +  L   Q+A+  +   D   ++   E LLQ  
Sbjct: 841  LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900

Query: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162
               K++++ ++     + +  + V+Q +   P + + G                   R  
Sbjct: 901  QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRG-------------------RLP 941

Query: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222
             LA C        D KQ E  +   +                         +G  + +  
Sbjct: 942  LLAVC--------DYKQVEVTVHKGDEC---------------------QLVGPAQPSHW 972

Query: 1223 KVLSPVDSGNKLVAEGNLY-----SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ 1277
            KVLS   SG++       +     + +++E V  +E +H+       +  V ++  L  Q
Sbjct: 973  KVLS--SSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ 1030

Query: 1278 NFLQNCQELTLWINDKLLTSQDVSYDEARN-LHNKWLKHQAFVAELASHEGWLENIDAEG 1336
            +  ++ Q +  W    L T + +  +E R  LH+  L +QAF+ +     G+        
Sbjct: 1031 SLRRDVQLIRSW---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGF-----GPE 1082

Query: 1337 KQLMDEKPQFTAL--VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
             +LM E+   +      Q L++L       Q   +E       +   D+RLQ  A   + 
Sbjct: 1083 DRLMAEREYGSCSHHYQQLLQSLE------QGAQEESRCQRCISELKDIRLQLEACETRT 1136

Query: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
            +  +   L   +P ++           +R+ +Q   +        A+V  +G+  G A L
Sbjct: 1137 VHRLRLPL-DKEPARECA---------QRIAEQQKAQ--------AEVEGLGK--GVARL 1176

Query: 1455 SIE-KRFLDLLEPLGRR---KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL 1510
            S E ++ L L EP       + +LE +  KL+  R L               SA Y   L
Sbjct: 1177 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL---------------SAIYLEKL 1221

Query: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570
            +T+ L ++  Q  +  +  H           +QL EA     Q +   L  L        
Sbjct: 1222 KTISLVIRGTQGAEEVLRAHE----------EQLKEA-----QAVPATLPEL-------- 1258

Query: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
            EA    L++LR   EAQQ   DA              + DE+   +E    + +RH  + 
Sbjct: 1259 EATKASLKKLRAQAEAQQPTFDA--------------LRDELRGAQEVGERLQQRHGERD 1304

Query: 1631 RAVEDYGRNIKQLASRAQGLLS 1652
              VE +   + QL  R Q +L+
Sbjct: 1305 VEVERWRERVAQLLERWQAVLA 1326



 Score = 45.4 bits (106), Expect = 6e-04
 Identities = 72/370 (19%), Positives = 144/370 (38%), Gaps = 28/370 (7%)

Query: 1352 QKLEALHRLWDELQATT---KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPG 1408
            ++LE L R+  +LQ      +E+     A   SD+RL         ++A +   R+ +  
Sbjct: 522  ERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL---------LAAGKVPQRAGEVE 572

Query: 1409 KDLTSVNRMLAKL-KRVEDQVNVRKEELGELFAQVPSMGEE----GGDADLSIEKRFLDL 1463
            +DL   + M+  L   V+   + R  +  +++ +V  + E       + +L ++      
Sbjct: 573  RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632

Query: 1464 LEPLGRRKKQLESSRAKLQIS--RDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQ 1521
               + +   Q    R +L+ S  R L+D   WVEE       A++G +L +V+  +  ++
Sbjct: 633  ATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 692

Query: 1522 TLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLR 1581
             L   I     ++E       QL  A     +D    LG L   + +L  ++  RL+ L 
Sbjct: 693  GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSLE 749

Query: 1582 DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIK 1641
              +    +   A +   W+ E+E   +  +            + +    R +E   + IK
Sbjct: 750  SLH---SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 806

Query: 1642 QLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVA---EERKRKLENMYHLFQLKRE 1698
            +L +    LL   HP    +   Q  +   ++ +  +    E   ++    +  F   RE
Sbjct: 807  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866

Query: 1699 TDDLEQWISE 1708
             +   Q + E
Sbjct: 867  AEGQLQKLQE 876



 Score = 35.0 bits (79), Expect = 0.79
 Identities = 46/190 (24%), Positives = 78/190 (41%), Gaps = 29/190 (15%)

Query: 1895 RRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIET 1954
            RR +L D+  ++      +DLL+W+E    +++  E   D+ SVE  +  H+G++  IE 
Sbjct: 646  RRPELEDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE- 699

Query: 1955 RSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEK-WEARWERLRMLLEVCQ 2013
                F A +E   S    + Q S   R   +  + R      K   +   RLR L  +  
Sbjct: 700  ---EFQAKIERARS---DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753

Query: 2014 FSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTT 2073
            F   A+    WL  +E      D+                 +++T   A++ +       
Sbjct: 754  FVAAATKELMWLNEKEEEEVGFDWS----------------DRNTNMTAKKESYSALMRE 797

Query: 2074 LELKERQIAE 2083
            LELKE++I E
Sbjct: 798  LELKEKKIKE 807


>gi|33188445 microfilament and actin filament cross-linker protein
           isoform a [Homo sapiens]
          Length = 5430

 Score =  298 bits (764), Expect = 3e-80
 Identities = 244/786 (31%), Positives = 375/786 (47%), Gaps = 73/786 (9%)

Query: 23  WDAPDDELDNDNSSARLFERSR--IKALADEREVVQKKTFTKWVNSHLARVSCRITDLYK 80
           W+ P  E     S   + + +   +  +ADER+ VQKKTFTKWVN HL +V   I DLY+
Sbjct: 45  WNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYE 104

Query: 81  DLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVD 140
           DLRDG  LI LLEVLSG  LP+  KG+MR H L+NV  AL FLK+++V L N+ + DI D
Sbjct: 105 DLRDGHNLISLLEVLSGIKLPRE-KGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITD 163

Query: 141 GNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTS 200
           GN +L LGLIWTIIL FQI DI +  + G    SAK+ LLLW Q  TAGY  +  TNF+S
Sbjct: 164 GNPKLTLGLIWTIILHFQISDIYISGESG--DMSAKEKLLLWTQKVTAGYTGIKCTNFSS 221

Query: 201 SWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTEN 260
            W DG  FNALIH++RPDL+D ++++  + R NLE AF VAER LG+  LLD EDV   +
Sbjct: 222 CWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPS 280

Query: 261 PDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQ 320
           PDEKS+ITYV + Y  F K+     EG   G+ I  A E +   ++Y      L+ WI+Q
Sbjct: 281 PDEKSVITYVSSIYDAFPKVP----EG---GEGIS-ATEVDSRWQEYQSRVDSLIPWIKQ 332

Query: 321 TITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKV 380
              +++ + F  +   ++     +  ++  E   K +EKG +E L   ++  +     K+
Sbjct: 333 HTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKL 392

Query: 381 YTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE 440
                G   +D+   W  L      RE +LR  + R E L Q+A +    A   E  L+ 
Sbjct: 393 ---PQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLT- 448

Query: 441 NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAY----EERVRALEDLAQELEKENYHDQ 496
               +A++    D A +E+ +      E+D   Y    E  +R L+   Q L  ENY+  
Sbjct: 449 ----LAKNTLQADAAHLESGQPVQ--CESDVIMYIQECEGLIRQLQVDLQILRDENYYQL 502

Query: 497 KRITAR----KDNILRLWSYLQELLQSRR---------QRLETTLALQKLFQDMLH--SI 541
           + +  R    +D ++ L      L +              L TT    +      H  S 
Sbjct: 503 EELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSST 562

Query: 542 DWMDE--IKAHLL---SAEFGKHLLEVEDLLQ--KHKLMEADIAIQGDKVKAI------- 587
            W  +   +A L+   S+E   +L  V +LL   +   M+ + A  G+ + ++       
Sbjct: 563 SWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQ 622

Query: 588 ------------TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635
                       +    +  EGK  Q       +  +  LE  + +L   ++ R   L+ 
Sbjct: 623 QHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAE-TLGKLETQYCKLKETSSFRMRHLQS 681

Query: 636 SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695
              L KF         W+ EKE+   + D+  + +++   +        EL         
Sbjct: 682 ---LHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRS 738

Query: 696 IFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDL 755
           +   A  +          +EA    V +Q   +K L    ++++++   +FQF  DA +L
Sbjct: 739 LQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDAREL 798

Query: 756 KAWLQD 761
           +++L++
Sbjct: 799 ESFLRN 804



 Score =  159 bits (401), Expect = 4e-38
 Identities = 324/1660 (19%), Positives = 683/1660 (41%), Gaps = 133/1660 (8%)

Query: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQ---LARRFDRKAAMRETWLSENQRLV 445
            ++D  +    LE  E R    L     RQ++LE    LA++F   A     +LS  ++ +
Sbjct: 3350 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3409

Query: 446  AQDN-FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK- 503
            A     G   A ++    +H+A+E D   +   V     + Q L       ++ + + K 
Sbjct: 3410 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3469

Query: 504  DNILRLWSYLQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEI------------KAH 550
            D++   +S +Q+    +   L+  L+  +LF +D +  ++W+ E+            K  
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529

Query: 551  LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
            +L  +   HL   E+++ + K    D AI+  +      A LK T G+     +  +IQ+
Sbjct: 3530 VLHRQHADHLALNEEIVNRKK--NVDQAIKNGQ------ALLKQTTGE-----EVLLIQE 3576

Query: 611  RISHLEQCFEELSNMAAGRKAQLEQSKRL-WKFFWEMDEAESWIKE-KEQIYSSLDYGKD 668
            ++  ++  + +++  ++     LEQ+++L  KF    +E   W++E +E++ +S      
Sbjct: 3577 KLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT 3636

Query: 669  LTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQ 727
               +   Q++ K  + E+      L+ + + +  ++    +     ++  + + + Q+  
Sbjct: 3637 GEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKL 3696

Query: 728  LKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKH 785
            + D        +  A +   Q++  AD   AW+ +  R L++   +  ++  T A  +  
Sbjct: 3697 VSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQ 3756

Query: 786  KDFLEELEESRGVMEHL-EQQAQGFPEEFRDSPDVTH-RLQALRELYQQVVAQADLRQQR 843
            K F  ++   +  M+ L   +++ F     +   V   + ++L + Y+ +      R  R
Sbjct: 3757 KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYAR 3816

Query: 844  LQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMT 902
            L+ A  L   F ET +    W+ E    +A++  P    D E ++ +     +EM+ L  
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI--DHEQLRQQ----QEEMRQLRE 3870

Query: 903  QIDGVNLAANSLVESGHPRSREVKQYQDHL-NTRWQAFQTLVSERREAV-DSALRVHNYC 960
             I       + L++ G P+ +E+   +  +   ++Q  + + ++ +E V   AL +    
Sbjct: 3871 SIAEHKPHIDKLLKIG-PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 3929

Query: 961  VDCEETSKWITDKTKVVESTKDLGRDL-------AGIIAIQRKLSGLER---DVAAIQAR 1010
                + +++      ++E+ ++L   L       A +  I+  +S  +    ++  +Q  
Sbjct: 3930 SQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPS 3989

Query: 1011 VDALERESQQLMDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-Q 1064
             +AL+R  ++L+       +D+  +  Q  L+++   W+ ++   + +E    +V +L +
Sbjct: 3990 FEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAE 4049

Query: 1065 AFLQDLDDFQAWLSITQKAVASEDMPESLPEA-EQLLQQHAGIKDEIDGHQDSYQRVKES 1123
             F  D+      +  TQ  V   + P   P   +Q ++    IK+E DG  +  + ++  
Sbjct: 4050 KFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRIL 4109

Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
            G  +I    + E   + + ++ ++  W  L + W+ R   L   +      +D  QA   
Sbjct: 4110 GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFD 4169

Query: 1184 -LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
             L N    L  + P  +       +   +D L  M+  + +V        KL  +G L  
Sbjct: 4170 WLDNTVIKLCTMPPVGT------DLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELML 4223

Query: 1243 DKIKEKVQ-------LIEDRHRKNN--EK-AQEASVLLRDNLELQNFLQNCQELTLWIN- 1291
             K  ++         L E +H   N  EK A     L    L L  F    +EL  W+  
Sbjct: 4224 KKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTH 4283

Query: 1292 -DKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL- 1349
             ++LL +Q     + + +  +  KH     ++ +H+  +E ++  G +L++      A  
Sbjct: 4284 TEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS 4343

Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQLRSDDPG 1408
            +  +LEA+++ W+ +   T+E+ Q L +         +   D    ++ ME QL +  P 
Sbjct: 4344 LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT 4403

Query: 1409 KDLTSVNR--------MLAKLKRVEDQVN--VRKEELGELFAQVPSMGEEGGDADLSIEK 1458
              L    R        + ++LK  E+  N  + K  L  L       G +   +   +E+
Sbjct: 4404 GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ 4463

Query: 1459 RFLDLLEPLGRRKKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQ 1514
            ++  +   +  RK +LE +     +    L++   W+   E+ L +A       N  TV 
Sbjct: 4464 KWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVL 4521

Query: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEI-DCQDLEERLGHLQSSWDRLREAA 1573
              +++++   NE+  H  ++ ++ Q G QL   ++  D   ++  L  +QS W+++ + +
Sbjct: 4522 SQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS 4581

Query: 1574 AGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQR 1631
              R + L DA + A+Q++    +   W+ + E ++ S+ EI  D +   + L +H   Q+
Sbjct: 4582 IERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK 4641

Query: 1632 AVED----YGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
             +      Y   I+    RA    +    + +++    G+V   +  +   + ER+ KLE
Sbjct: 4642 TLGGKQPVYDTTIR--TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699

Query: 1688 NMYHLF--QLKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
                LF  Q       L  W+   E +L    P  G D D V  L D  + F +E G   
Sbjct: 4700 EAL-LFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELG--- 4754

Query: 1744 QERVDNVNAFIE---RLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
             +R   V         LI+    +   +      L+  W  + +L  ++   L  +    
Sbjct: 4755 -KRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQA 4813

Query: 1801 RYFY-TGAEILGLIDEKHRELPEDVGL--DASTAESFHRVHTAFERELHLLGVQVQQFQD 1857
              F  T   +L  + E  + L     L  D    +S    H  F +++    V V     
Sbjct: 4814 EVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVA 4873

Query: 1858 VATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA--DKFRFFSMARDL 1915
            +   +      +    I++    + A ++ +L   A +  Q ++TA  +      +  +L
Sbjct: 4874 MGEVILAVCHPDCITTIKHWITIIRARFEEVL-TWAKQHQQRLETALSELVANAELLEEL 4932

Query: 1916 LSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
            L+W+   E+ + Q + +  P+++  V+ L+  HQ    E+
Sbjct: 4933 LAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEM 4972



 Score =  157 bits (397), Expect = 1e-37
 Identities = 375/1913 (19%), Positives = 765/1913 (39%), Gaps = 235/1913 (12%)

Query: 288  KRVGKVIDHAIETEKMIEKYSGLASDL---LTWIEQTITVLNSRKFANSLTG-----VQQ 339
            K+ GK+ +     ++ +E   G   D    L  +    T     +    + G     + Q
Sbjct: 3145 KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQ 3204

Query: 340  QLQAFSTYRTVEKPP---KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAW 396
            QL  F  ++  +  P   K Q+   L   L  IQS  +  + +    HD   + +IN  W
Sbjct: 3205 QLADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HD---MEEINARW 3258

Query: 397  ESLEEAEYRRELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLVA-QDNFG 451
             +L +   +R   L+  L+     Q+ LE L            +WL++ + L+A Q    
Sbjct: 3259 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLL-----------SWLADTEELIANQKPPS 3307

Query: 452  YDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE----LEKENYHDQKRITARKDNIL 507
             +   V+A  ++ + ++      ++R   ++ L  E     +     D+++IT + +++ 
Sbjct: 3308 AEYKVVKAQIQEQKLLQR---LLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE 3364

Query: 508  RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAE-FGKHLLEVED 565
              W+ L     +R+++LE  L L K F +    I D++   +  L ++E  G    +++ 
Sbjct: 3365 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3424

Query: 566  LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625
             + +HK +E DI      V    A  +  +      P +  V+ ++I  L+  + E+ + 
Sbjct: 3425 QIIRHKALEEDIENHATDVHQ--AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482

Query: 626  AAGRKAQLEQSKRLWKFFWEMDEAE--SWIKEKEQIYSSL---DYGKDLTSVLILQRKHK 680
               + A L+Q+    + F E DE E  +W+ E E   SS+   D+ +D     +L R+H 
Sbjct: 3483 CCRKAALLDQALSNARLFGE-DEVEVLNWLAEVEDKLSSVFVKDFKQD-----VLHRQHA 3536

Query: 681  ---AFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKK 737
               A  +E+     +++Q  +  +G    KQ    ++    +++     +  D+     K
Sbjct: 3537 DHLALNEEIVNRKKNVDQAIK--NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSK 3594

Query: 738  NLQDAENFFQ----FQGDADDLKAWLQDAHRLLS--------GEDVGQDEGATRALGKK- 784
             L+  E   Q    FQ   ++L  WL++    L+        GE + Q +   + L K+ 
Sbjct: 3595 ALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEV 3654

Query: 785  --HKDFLEELEE-SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADL-- 839
              H+  L+ + E SR ++E +  +A+   ++     D   + + + +   Q V + D   
Sbjct: 3655 MEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS--DANEQYKLVSDTIGQRVDEIDAAI 3712

Query: 840  -RQQRLQEALDLYTVF-GETDACELWMG----EKEKWLAEMEMPDTLEDLEVVQHRFDIL 893
             R Q+ ++A D    +  ET    + +G    E+++  A++++      +++++H+ D +
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS-IDIIRHK-DSM 3770

Query: 894  DQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSA 953
            D E+ +  ++I G           G  +   +++  + L  +++A   L SER   ++ A
Sbjct: 3771 D-ELFSHRSEIFGT---------CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 3820

Query: 954  -LRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
             + V+ +    EE S WI +   ++        D   +   Q ++  L   +A  +  +D
Sbjct: 3821 QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 3880

Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE-VSQLQAFLQDLD 1071
             L +   QL + +PE+ E + ++ +  E ++  +++ ++ +   L E VSQ     +  D
Sbjct: 3881 KLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 3940

Query: 1072 DFQAWLSITQKAVASEDMPESLP----EAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV 1127
              +  L   +   +   MP  +P    +  + +  +     E++  Q S++ +K  GE++
Sbjct: 3941 KIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL 4000

Query: 1128 I---QG-QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQE-FQKDAKQAEA 1182
            I   QG   D     +  +L+ +   W  +    E R       L   E F  D      
Sbjct: 4001 IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLT 4060

Query: 1183 ILSNQEYTLAHLEPP--------DSLEAAEA------GIRKFEDFLGSM---------EN 1219
             + + +  +  LE P          +EAAE       G+ +  +F+  +         E 
Sbjct: 4061 TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET 4120

Query: 1220 NRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNF 1279
             + +V   +D  N   A  NL +   KE+++ +ED        A +A+V  +D L     
Sbjct: 4121 EKPEVRKSIDEMNN--AWENL-NKTWKERLEKLED--------AMQAAVQYQDTL----- 4164

Query: 1280 LQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEG 1336
                Q +  W+++   KL T   V  D    + ++  + + F  E+   +  +E ++ +G
Sbjct: 4165 ----QAMFDWLDNTVIKLCTMPPVGTD-LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG 4219

Query: 1337 KQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA--DLN 1392
            + ++ +    T   ++ + L  L  LW+ L      +   L  A  +  + Q HA  +L 
Sbjct: 4220 ELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQ-HALEELM 4278

Query: 1393 KWISAMEDQLRSDDP------------GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
             W++  E+ L +  P             K     N +LA    VE  VN    EL E   
Sbjct: 4279 SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVET-VNKAGNELLE--- 4334

Query: 1441 QVPSMGEEGGDADLSIEKR---FLDLLEPLGRRKKQLESSRAKLQ-ISRDLEDETLWVEE 1496
               S G++       +E     +  +L+    R++QL+S+  + Q    ++ED  L +  
Sbjct: 4335 --SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTR 4392

Query: 1497 -RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD- 1554
                L+ S   G   +T +  +  +  L +++         +L +G+ ++ + +      
Sbjct: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4452

Query: 1555 -LEERLGHLQSSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWI--GEQELYVISD 1610
              E+ +  L+  W  +      R  +L +A N A ++     E   W+   EQ L + S 
Sbjct: 4453 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASP 4512

Query: 1611 E-------IPKDEEGAIVM--LKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661
                    + + EE  +    +  H  Q   ++  G  +K L+ +   +L         I
Sbjct: 4513 PSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL---------I 4563

Query: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMY-HLFQLKRETDDLEQWISEKEL-VASSPEMG 1719
              L   V   +  +   + ER R L++      Q       L  W+ + E  + S  E+ 
Sbjct: 4564 KNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS 4623

Query: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMW 1779
             D D + L   K ++F +  G  G++ V +      R +     E   + E    L+   
Sbjct: 4624 NDPDKIKLQLSKHKEFQKTLG--GKQPVYDTTIRTGRAL----KEKTLLPEDSQKLDNFL 4677

Query: 1780 ADLLELIDTRM-QLLAASYDLHRYFYTGAEIL----GLIDEKHR---ELPED--VGLDAS 1829
             ++ +  DT   + +   + L        + +     L+D  ++   +L ED  V  D  
Sbjct: 4678 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 4737

Query: 1830 TAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALL 1889
               +    H  F++EL      VQ  +     L    + +    ++ + QE+S  W  + 
Sbjct: 4738 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGREL-IENSRDDTTWVKGQLQELSTRWDTVC 4796

Query: 1890 DACAGRRTQLVDTADKFRFF-SMARDLLSWMESIIRQIETQER-PRDVSSVELLMKYHQG 1947
                 ++++L     +   F      LL W+    + +  +   P D  +++ L+  H+ 
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKE 4856

Query: 1948 INAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRM 2007
               ++E +  + ++ + +GE +L   H       +    ++  R E    W A+  + R+
Sbjct: 4857 FMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW-AKQHQQRL 4915

Query: 2008 LLEVCQFSRDASVAE---AWLIAQEPYLASGD---FGHTVDSVEKLIKRHEAF 2054
               + +   +A + E   AW+   E  L   D       +D V+ LI  H+ F
Sbjct: 4916 ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTF 4968



 Score =  154 bits (390), Expect = 7e-37
 Identities = 331/1658 (19%), Positives = 663/1658 (39%), Gaps = 142/1658 (8%)

Query: 494  HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLL 552
            HD + I AR       W+ L + +  R  +L+  L     FQD L  +  W+ + +  + 
Sbjct: 3249 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301

Query: 553  -----SAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQV 607
                 SAE+      V+  +Q+ KL++  +  +   V  + A   +  +    +  D + 
Sbjct: 3302 NQKPPSAEYKV----VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSA--ELADREK 3355

Query: 608  IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE--KEQIYSSLDY 665
            I  ++  LE  + EL + AA R+ QLE    L K F E  E  S      ++++ +S   
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415

Query: 666  GKDLTSVLILQRKHKAFEDELRGLDAHLEQ---IFQEAHGMVARKQFGHPQIEARIKEVS 722
            G     +     +HKA E+++      + Q   I Q    + +  + G   +  +I  + 
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQG--VLSEKIDSLQ 3473

Query: 723  AQWDQLKDLAAFCKKNL---QDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEG 776
            A++ +++D    C+K     Q   N   F  D  ++  WL +    LS    +D  QD  
Sbjct: 3474 ARYSEIQDRC--CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 3529

Query: 777  ATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-----VTHRLQALRELYQ 831
                L ++H D L   EE     ++++Q  +      + +       +  +L  ++  Y 
Sbjct: 3530 ---VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 3586

Query: 832  QVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME-MPDTLEDLEVVQHR 889
             +   +    + L++A  L T F  T +    W+ E E+ LA       T E +   Q R
Sbjct: 3587 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQR 3646

Query: 890  FDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAFQTLVSERRE 948
               L +E+      +D VN  + +L+E    R+RE + +     N +++     + +R +
Sbjct: 3647 QKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 3706

Query: 949  AVDSAL-RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAI 1007
             +D+A+ R   Y    +    W+ +  + + +   +  +     A  +       D+   
Sbjct: 3707 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 3766

Query: 1008 QARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQA-- 1065
            +  +D L     ++  +  E+++ +   Q+  E L Q  +       +    + + Q   
Sbjct: 3767 KDSMDELFSHRSEIFGTCGEEQKTV--LQEKTESLIQQYEAISLLNSERYARLERAQVLV 3824

Query: 1066 --FLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAG---IKDEIDGHQDSYQRV 1120
              F +  ++   W+  T+  +A   +P    + EQL QQ      +++ I  H+    ++
Sbjct: 3825 NQFWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL 3882

Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQ-EFQKDAKQ 1179
             + G ++ +   + E  ++ ++ +  +  +  +      R+  L + +    +  +   +
Sbjct: 3883 LKIGPQLKELNPE-EGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK 3941

Query: 1180 AEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDS----GNKLV 1235
             E +L   E   + L  P  + A    IR+      S     +K+    ++    G +L+
Sbjct: 3942 IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001

Query: 1236 -----AEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLW 1289
                 A+ +L + +I++K+  +         +A+E  +   D LEL + F  +   L   
Sbjct: 4002 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4061

Query: 1290 INDKLLTSQDVSYD-EARNLHNKWLKHQAFVAELASHEG-----WLENIDAEGKQLM--- 1340
            I D    +QD+ +D E+  +    +K Q   AE    E       LE I   G  L+   
Sbjct: 4062 IKD----TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4117

Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISA 1397
               EKP+    V + ++ ++  W+ L  T KE+ + L  A  + ++ Q T   +  W+  
Sbjct: 4118 GETEKPE----VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4173

Query: 1398 MEDQLRSDDP-GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD-ADLS 1455
               +L +  P G DL +V   L ++K  + +V  ++ E+ +L  Q   M ++  D  D  
Sbjct: 4174 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRD 4233

Query: 1456 IEKRFL--------DLLEPLGRRKKQLESSRAKL-QISRDLEDETLWVE--ERLPLAQSA 1504
            I +  L        +L E +  R+ +LE +   L Q    LE+   W+   E L  AQ  
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293

Query: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEA-AEIDCQDLEERLGHLQ 1563
              G + + +++ + K+  L+N++L H   VE V + G +L+E+ A  D   L  RL  + 
Sbjct: 4294 ISG-DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMN 4352

Query: 1564 SSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWIGEQELYVISDEIPKD-EEGAIV 1621
              W+ + +    R Q+L+    +AQ ++ + ++    +   E  + + +      E A  
Sbjct: 4353 QCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE 4412

Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-----EQIIRLQGQVDKHYAGLK 1676
             L  H+     ++       QL  + + +L +    G     EQ + L   +++ +  + 
Sbjct: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL---LEQKWHVVS 4469

Query: 1677 DVAEERKRKLENMYHLF-QLKRETDDLEQWISEKEL---VASSPEMGQDFDHVTLLRDKF 1732
               EERK KLE   +L  + +    +   W++  E    +AS P +    + V    ++ 
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL--ILNTVLSQIEEH 4527

Query: 1733 RDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQL 1792
            + FA E  A   + ++      +    +   +   I      +   W  +++    R + 
Sbjct: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 4587

Query: 1793 LAASYDLHRYFYTGAEILGLID-----EKHRELPEDVGLDASTAESFHRVHTAFERELHL 1847
            L  +    + F+   +   LID     E H +   ++  D    +     H  F++ L  
Sbjct: 4588 LDDARKRAKQFHEAWK--KLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG- 4644

Query: 1848 LGVQVQQFQDVATRLQTAYAG-----EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
                 Q   D   R   A        E ++ + N   EV   W  +      R+ +L + 
Sbjct: 4645 ---GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEA 4701

Query: 1903 A-DKFRFFSMARDLLSWMESIIRQI-ETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960
                 +F    + L+ W+  +  Q+ E Q    D+  V  LM  H+    E+  R+    
Sbjct: 4702 LLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761

Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRD-AS 2019
                 G  L++     +  ++ +LQ++ +R   + +   ++  RL   L+  +  RD   
Sbjct: 4762 VLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 4821

Query: 2020 VAEAWLIAQEPYLA-SGDFGHTVDSVEKLIKRHEAFEK 2056
            +   WL   E  L   G      ++++ LI  H+ F K
Sbjct: 4822 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMK 4859



 Score =  134 bits (336), Expect = 1e-30
 Identities = 259/1325 (19%), Positives = 533/1325 (40%), Gaps = 118/1325 (8%)

Query: 287  GKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQT---ITVLNSRKFANSLTGVQQQLQA 343
            G+RV + ID AI+     ++Y   A   L W+ +T   +  L   +     T  Q Q+Q 
Sbjct: 3702 GQRVDE-IDAAIQRS---QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757

Query: 344  FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
              +   +       E       LF+ +S       +++     +  + +    ESL +  
Sbjct: 3758 AFSIDIIRHKDSMDE-------LFSHRS-------EIFGTCGEEQKTVLQEKTESLIQQY 3803

Query: 404  YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-DNFGYDLAAVEAAKK 462
                L       R E+ + L  +F         W+ E + L+AQ  +   D   +   ++
Sbjct: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 3863

Query: 463  KHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQ 522
            +   +    A ++  +  L  +  +L++ N  + + +  +      +++ ++E ++ R  
Sbjct: 3864 EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRAL 3923

Query: 523  RLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVE-DLLQKHKLMEADIAIQG 581
             L+  ++      +    I+ M E   +L S      L+  E D +++         ++ 
Sbjct: 3924 ALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 3983

Query: 582  DKVKAITAATLKFTE---GKGYQPCDPQV----IQDRISHLEQCFEELSNMAAGRKAQ-L 633
            +K++    A  +  E   G+  Q  D  +    IQD++  +   +E++   A  R+ + L
Sbjct: 3984 EKLQPSFEALKRRGEELIGRS-QGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042

Query: 634  EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDY-GKDLTSVLILQRKHKAFEDELRGLDAH 692
            +  +   KF+++M    + IK+ + I   L+  G D + +       +  ++E  GL   
Sbjct: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEE 4102

Query: 693  LEQI-FQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQG 750
            LE I    A  + A  +   P++   I E++  W+ L        + L+DA +   Q+Q 
Sbjct: 4103 LEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD 4162

Query: 751  DADDLKAWLQDAH-RLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
                +  WL +   +L +   VG D    +    + K+F  E+ + +  ME L  Q +  
Sbjct: 4163 TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELM 4222

Query: 810  PEEFRDSPD---VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMG 865
             ++  D  D   +   L  L+ L++ +  +   RQ +L+ AL     F    +    W+ 
Sbjct: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282

Query: 866  EKEKWL-AEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGH-PRSR 923
              E+ L A+  +    + +EV   +  +L  ++      ++ VN A N L+ES     + 
Sbjct: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS 4342

Query: 924  EVKQYQDHLNTRWQAFQTLVSERREAVDSALR-VHNYCVDCEETSKWITDKTKVVESTKD 982
             ++   + +N  W++      ER + + S L+    +  + E+    +T     + ++K 
Sbjct: 4343 SLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKP 4402

Query: 983  LGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ---KEDIGQRQKH- 1038
             G    G+    R+      +   + +++ A E    QL+D        ++D G   K  
Sbjct: 4403 TG----GLPETAREQLDTHME---LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE 4455

Query: 1039 -----LEELWQGLQQSLQGQEDLLGEVSQLQA-FLQDLDDFQAWLSITQKAVASEDMPES 1092
                 LE+ W  +   ++ ++  L E   L   F   L +F  WL++ ++++     P  
Sbjct: 4456 QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL 4515

Query: 1093 -LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
             L      +++H    +E++ H+D    + ++G ++       + +L+   L  + + W 
Sbjct: 4516 ILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE 4575

Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQA----EAILSNQEYTLAHLEP-------PDSL 1200
             + +    R  +L       + +K AKQ     + ++   E   +HL+        PD +
Sbjct: 4576 KVVQRSIERGRSL------DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 4629

Query: 1201 EAAEAGIRKFEDFLGSMENNRD-----------KVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
            +   +  ++F+  LG  +   D           K L P DS  KL    + +  ++++K 
Sbjct: 4630 KLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKL----DNFLGEVRDKW 4684

Query: 1250 QLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW---INDKLLTSQDVSYDEAR 1306
              +  +  +   K +EA +          F+   Q L  W   +  +L   Q V + +  
Sbjct: 4685 DTVCGKSVERQHKLEEALLFSGQ------FMDALQALVDWLYKVEPQLAEDQPV-HGDLD 4737

Query: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
             + N    H+ F  EL    G ++ +   G++L++     T  V  +L+ L   WD +  
Sbjct: 4738 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 4797

Query: 1367 TTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK----- 1420
             +  K   L  A + +++   T   L +W+S  E  LR      D T   + L       
Sbjct: 4798 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 4857

Query: 1421 LKRVEDQ-VNVRKE-ELGELFAQV--PSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLES 1476
            +K+VE++ V+V     +GE+   V  P            I  RF ++L    + +++LE+
Sbjct: 4858 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917

Query: 1477 SRAKLQISRDLEDETL----WVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTP 1532
            + ++L  + +L +E L    W E  L          N+  V+  + ++QT   E+    P
Sbjct: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977

Query: 1533 RVEDV 1537
             V+ V
Sbjct: 4978 DVDRV 4982



 Score =  119 bits (299), Expect = 2e-26
 Identities = 319/1693 (18%), Positives = 678/1693 (40%), Gaps = 149/1693 (8%)

Query: 421  EQLARRFDRKAAMRETWLSENQRLVAQD-NFGYDLAAVEAAKKKHE----AIETDTAAYE 475
            +Q  + FD       TWL + Q   A++      L  +++  +++E    ++   + +YE
Sbjct: 2734 QQFQQMFDEL----RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE 2789

Query: 476  ERVRALEDLAQELE--KENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
              V   E L   +   +E    Q ++   K++    W  L +    R+ RL+  +   + 
Sbjct: 2790 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNH----WEELSKKTADRQSRLKDCMQKAQK 2845

Query: 534  FQDMLHS-IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATL 592
            +Q  +   + W+++ KA +         +++E  L + K M  ++  +   ++ + +A  
Sbjct: 2846 YQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 2905

Query: 593  KFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKF---FWEMDE 648
                       D   I+D  + + Q  + ++     +   LE+ ++RL +F   F  +++
Sbjct: 2906 ILINSS---EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEK 2962

Query: 649  AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
                 K + +I+ +L  G    S   L+ K +A ++ L+ L+  ++ +     G+V    
Sbjct: 2963 KVEGAKHQLEIFDAL--GSQACSNKNLE-KLRAQQEVLQALEPQVDYLRNFTQGLVEDAP 3019

Query: 709  FGHPQIEARIKEVSAQWDQLK---DLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRL 765
             G    +   +   AQ + L+    + + C       E   QF     ++ + L D    
Sbjct: 3020 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDE 3079

Query: 766  LSGED-VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE--FRDSPDVTHR 822
            L G   +G+D  + ++  +  + FL ++   +  +E  E + +   EE    D   +   
Sbjct: 3080 LDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRE 3139

Query: 823  LQALRELYQQVVAQADLRQQRLQEAL----DLYTVFGETDACELWMGEKE--KWLAEMEM 876
            L+AL +   ++  +   RQ++L+  L    D Y      +       E E  +W+   E+
Sbjct: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199

Query: 877  P---DTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRS--REVKQYQDH 931
                  L D ++ Q       +++  L  ++  VN     L++S       + ++   + 
Sbjct: 3200 EIINQQLADFKMFQK------EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253

Query: 932  LNTRWQAFQTLVSERREAVDSALRVHNYCVDC-EETSKWITDKTKVVESTKDLGRDLAGI 990
            +N RW      V++R   +  AL       D  E    W+ D  +++ + K    +   +
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313

Query: 991  IAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQS 1049
             A  ++   L+R +   +A VD L+ E  ++  S     +E I  + + LE  W  L   
Sbjct: 3314 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3373

Query: 1050 LQGQ----EDLLGEVSQLQAFLQDLDDFQAWLSITQKAVA-SEDMPESLPEAEQLLQQHA 1104
               +    ED+L    Q     + + DF   LS+T+K +A SE +     + +Q + +H 
Sbjct: 3374 AAARQKQLEDILVLAKQFHETAEPISDF---LSVTEKKLANSEPVGTQTAKIQQQIIRHK 3430

Query: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL 1164
             ++++I+ H     +  + G+ +    +  E  +L ++++ L   ++ +      ++  L
Sbjct: 3431 ALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALL 3490

Query: 1165 AQCLGFQE-FQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NN 1220
             Q L     F +D  +    L+  E  L+ +   D  +  +   R+  D L   E   N 
Sbjct: 3491 DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ--DVLHRQHADHLALNEEIVNR 3548

Query: 1221 RDKVLSPVDSGNKLVAEGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNF 1279
            +  V   + +G  L+ +        I+EK+  I+ R+      + +A   L    +L   
Sbjct: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608

Query: 1280 LQNC-QELTLW---INDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAE 1335
             Q+  +ELT W   + ++L TS   S      +     + +    E+  H   L+ ++  
Sbjct: 3609 FQSTYEELTGWLREVEEELATSGGQS-PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 3667

Query: 1336 GKQLMDEKPQFTALVSQKLEA-LHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLN-K 1393
             + L++  P        KL +  +  +  +  T  ++   + AA     + +  AD    
Sbjct: 3668 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 3727

Query: 1394 WISAMEDQLRSDDP---GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSM-GEEG 1449
            W++  + +L +  P    +D T+    + K   ++  +   K+ + ELF+    + G  G
Sbjct: 3728 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID--IIRHKDSMDELFSHRSEIFGTCG 3785

Query: 1450 GDADLSIEKRFLDLLEPL-------GRRKKQLESSRAKL-QISRDLEDETLWVEE-RLPL 1500
             +    ++++   L++           R  +LE ++  + Q     E+ + W+EE R  +
Sbjct: 3786 EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALI 3845

Query: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
            AQ      + + ++   ++ + L+  I  H P ++ +L+ G QL E    + + +EE+  
Sbjct: 3846 AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ 3905

Query: 1561 HLQSSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWIGEQELY--------VISDE 1611
              ++ + +++E    R   L +A +++ Q     D+ E  +   E          +I  E
Sbjct: 3906 KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE 3965

Query: 1612 IPK------DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQ 1665
            + K      D + A V L+   + Q + E   R  ++L  R+QG  +      ++I    
Sbjct: 3966 VDKIRECISDNKSATVELE---KLQPSFEALKRRGEELIGRSQG--ADKDLAAKEIQDKL 4020

Query: 1666 GQVDKHYAGLKDVAEERKRKLENMYHLFQ------------LKRETD---DLEQWISEKE 1710
             Q+   +  +K  AEER+ K  ++  L +            +K   D   DLE    +  
Sbjct: 4021 DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4080

Query: 1711 LVASSPEMGQDFDHVTLLRDKFRDFARETG-----AIGQERVDNVNAFIERLIDAGHSEA 1765
            ++    E  +     T    +  +F R  G     A G+     V   I+ + +A     
Sbjct: 4081 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA----- 4135

Query: 1766 ATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVG 1825
                 W + LN+ W + LE ++  MQ      D  +  +   +   +   K   +P  VG
Sbjct: 4136 -----W-ENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVI---KLCTMP-PVG 4185

Query: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVA-TRLQTAYAGEKAEAIQNKEQEVSAA 1884
             D +T +        F+ E++   +++++        L+ A      + I+    E+   
Sbjct: 4186 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4245

Query: 1885 WQALLDACAGRRTQLVDTADKFRFFSMA-RDLLSWMESIIRQIETQERP--RDVSSVELL 1941
            W+ L +  A R+ +L         F  A  +L+SW+      ++ Q RP   D   +E+ 
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ-RPISGDPKVIEVE 4304

Query: 1942 MKYHQGINAEIETRSKNFSACLELGESLLQRQ-HQASEEIREKLQQVMSRRKEMNEKWEA 2000
            +  H  +  ++           + G  LL+      +  +R +L+ +    + + +K E 
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364

Query: 2001 RWERLRMLLEVCQ 2013
            R ++L+  L+  Q
Sbjct: 4365 REQQLQSTLQQAQ 4377



 Score =  117 bits (293), Expect = 1e-25
 Identities = 271/1399 (19%), Positives = 558/1399 (39%), Gaps = 137/1399 (9%)

Query: 417  QEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEE 476
            Q+ ++  A  F       E ++ ENQ  ++          +  AK+++EA++ +T   ++
Sbjct: 1596 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 1655

Query: 477  RVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
             +      A + E E     K +   K  I  L  ++  +  S  Q L     +++L   
Sbjct: 1656 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 1715

Query: 537  MLH--SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
             L   ++D  D       + E      +++   +  K    ++  Q       T +   F
Sbjct: 1716 SLEKGALDTTDGYMGVNQAPE------KLDKQCEMMKARHQELLSQQQNFILATQSAQAF 1769

Query: 595  TEGKGYQ--PCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSK----RLWKFFWEMDE 648
             +  G+   P + Q++Q ++  L+   E+ S   A  +A+L+Q +     L KF  +  E
Sbjct: 1770 LDQHGHNLTPEEQQMLQQKLGELK---EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 1826

Query: 649  AESWIKEKEQIYSSLDYGKDLTSVL--ILQRKHKAFED------ELRGLDAHLEQIFQEA 700
             ESW++  E+   ++  G      L  +L+R+    ED      +LR +    +++    
Sbjct: 1827 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886

Query: 701  HGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKA 757
            +     K+       ++ ++K+ + ++  L         +L      + QFQ  AD L+A
Sbjct: 1887 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 1946

Query: 758  WLQ----DAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE-E 812
            W+Q    +  +LLS + V  D G  +      K   EEL E +  +E L++ A+   E E
Sbjct: 1947 WMQACEANVEKLLS-DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2005

Query: 813  FRDSPDVTH---RLQALRELYQQVVAQADLRQQRLQEAL-DLYTVFGETDACELWMGEKE 868
               +PD  H      ++   +Q +      R   LQ+A+    +V    ++    +GE E
Sbjct: 2006 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2065

Query: 869  KWLAEMEMPDTLEDLEVVQHRFDI---LDQEMKTLMTQIDGVNLAANSLVESGHPRSREV 925
            + L   ++        V+Q        L Q++    + ++         +E+    +  V
Sbjct: 2066 QNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2123

Query: 926  KQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS----KWITDKTKVVESTK 981
               Q  L    Q F+ L  +++E   S  ++       E  S    +++ +K++++ S  
Sbjct: 2124 --LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181

Query: 982  DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEE 1041
               +D+       +++  L  ++   Q  +D LE    +L  S      D+ Q Q  ++ 
Sbjct: 2182 QPDQDITHFF---QQIQELNLEMEDQQENLDTLEHLVTEL--SSCGFALDLCQHQDRVQN 2236

Query: 1042 L---WQGLQQSLQGQE-DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAE 1097
            L   +  LQ++++ +E D      QL  F + +  FQ WL  T+ ++   +   S  E E
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELE 2296

Query: 1098 QLLQQHAGIKDEIDGHQDSYQRVKESG---EKVI--------QGQTDPEYLLLGQR---- 1142
            + ++    + D+        + +   G   E +I        QG+T      +G      
Sbjct: 2297 KQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSV 2356

Query: 1143 ---------------LEGLDTGWNALGRMWESRSHTLAQCLG-FQEFQKDAKQAEAILSN 1186
                           +  ++  +  LG +   R  +L   L   +E  K+A      L +
Sbjct: 2357 NGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLES 2416

Query: 1187 QEYTLAHLE---PPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDS-GNKLVAEGNLYS 1242
            +E  L  ++    P   E  +A     + FL  +E N  K+    ++    LV   N   
Sbjct: 2417 KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN--- 2473

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-----LQNFLQNCQELTLWINDKLL-- 1295
             +  E  + I++      E+A E +V  +  LE     L  F     +L  W+ +K L  
Sbjct: 2474 SQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMM 2533

Query: 1296 -TSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM---DEKPQFTALVS 1351
                 +S D    L+ +  + Q  + E  +     E ++   + ++    +    T+ V 
Sbjct: 2534 GVLGPLSID-PNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592

Query: 1352 QKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRSDDP-GK 1409
            ++L+++++ W EL      ++  +  A     + Q    DL++ + A+  +L        
Sbjct: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652

Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL--SIEKRFLDLLEPL 1467
               +V + L +   +   +     E+ E       +    G+  L   ++KR   +  PL
Sbjct: 2653 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 2712

Query: 1468 -------GRRKKQLESSRAKLQISRDLEDE-TLWVEER-LPLAQSADYGTNLQTVQLFMK 1518
                     R  +L+++ A  Q  + + DE   W++++    A++      L+ +Q  ++
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772

Query: 1519 KNQTLQNEILGHTPRVEDVLQRGQQLVEAAE--IDCQDLEERLGHLQSSWDRLREAAAGR 1576
            +N+  Q  +  H+   E ++  G+ L+ +     + + L+ +L  L++ W+ L +  A R
Sbjct: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 2832

Query: 1577 LQRLRDA-NEAQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
              RL+D   +AQ+Y    ++   WI +      EL V  D  P   E +++  K  L + 
Sbjct: 2833 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLD--PVQLESSLLRSKAMLNE- 2889

Query: 1631 RAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMY 1690
              VE     ++ L S A  L+++   + + I   +  ++++   +  V EE + K  ++ 
Sbjct: 2890 --VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN---MDAVTEELQAKTGSLE 2944

Query: 1691 HLFQLKRETDDLEQWISEK 1709
             + Q  RE  +  + I +K
Sbjct: 2945 EMTQRLREFQESFKNIEKK 2963



 Score =  108 bits (271), Expect = 4e-23
 Identities = 332/1869 (17%), Positives = 737/1869 (39%), Gaps = 182/1869 (9%)

Query: 333  SLTGVQQQLQAFSTYRTVEKPPKFQEKGN--LEVLLFTIQSRMRANN--QKVYTPHDGK- 387
            +L   QQ  Q F   RT     + Q+  N  +   L  +QS+++ N   QK    H G  
Sbjct: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788

Query: 388  --LVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRF-DRKAAMRET------- 436
              +V++      S+   E +R   L+N+L+  +   E+L+++  DR++ +++        
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKR--TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 2846

Query: 437  ---------WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE 487
                     W+ + +  +++     D   +E++  + +A+  +       +  L   A  
Sbjct: 2847 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906

Query: 488  LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEI 547
            L   +  D+  I   K  I +    + E LQ++   LE      + FQ+   +I+     
Sbjct: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE----- 2961

Query: 548  KAHLLSAEFGKHLLEVEDLLQKHKLMEADIA---IQGDKVKAITAAT---LKFTEGKGYQ 601
                   E  KH LE+ D L        ++     Q + ++A+         FT+G    
Sbjct: 2962 ----KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED 3017

Query: 602  PCD----PQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKE 657
              D     Q++       ++  E    + +G      + + + +F   + E  S + + +
Sbjct: 3018 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3077

Query: 658  QIYSSLD-YGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ----FG-H 711
                 +   G+D  S+       + F +++  L   +E    E   M+  +      G  
Sbjct: 3078 DELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK 3137

Query: 712  PQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRL-----L 766
             ++EA  K+     ++ K      +  L   E+F++     +D     ++A  L      
Sbjct: 3138 RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT 3197

Query: 767  SGEDVGQDEGATRALGKKHKDFLE-ELEESRGVMEHLEQQA------QGFPEEFRDSPDV 819
              E + Q     +   K+  D L+ +L++  G+ + L Q A      QG      D  ++
Sbjct: 3198 EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEH---DMEEI 3254

Query: 820  THRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACE---LWMGEKEKWLAEMEM 876
              R   L +   Q +AQ       LQEAL     F   DA E    W+ + E+ +A  + 
Sbjct: 3255 NARWNTLNKKVAQRIAQ-------LQEALLHCGKF--QDALEPLLSWLADTEELIANQKP 3305

Query: 877  PDTLEDLEVVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHL 932
            P    + +VV+ +     +L + +      +D +      + +S     RE +    + L
Sbjct: 3306 PSA--EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363

Query: 933  NTRWQAFQTLVSERREAVDSALRV-HNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991
             +RW    +  + R++ ++  L +   +    E  S +++   K + +++ +G   A I 
Sbjct: 3364 ESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ 3423

Query: 992  AIQRKLSGLERDVAAIQARVDALERESQQLMD-SHPEQKEDIGQRQKHLEELWQGLQQSL 1050
                +   LE D+      V    +  Q L   + P ++  + ++   L+  +  +Q   
Sbjct: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483

Query: 1051 QGQEDLLGE-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA---GI 1106
              +  LL + +S  + F +D  +   WL+  +  ++S  + +   + + L +QHA    +
Sbjct: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF--KQDVLHRQHADHLAL 3541

Query: 1107 KDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ 1166
             +EI   + +  +  ++G+ +++  T  E LL+ ++L+G+ T +  +         TL Q
Sbjct: 3542 NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQ 3601

Query: 1167 CLGFQ-EFQKDAKQAEAILSNQEYTLAHL--EPPDSLEAAEAGIRKFEDFLGSME----- 1218
                  +FQ   ++    L   E  LA    + P   +  +   R+ E     ME     
Sbjct: 3602 ARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL 3661

Query: 1219 ---NNRDKVLSPV------DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQE 1265
               N   + L  +      +  +KLV++ N    L SD I ++V  I+   +++ +  Q 
Sbjct: 3662 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 3721

Query: 1266 ASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASH 1325
            A   L    E +  L     + L   ++  T+  +   +A ++    ++H+  + EL SH
Sbjct: 3722 ADAELAWVAETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI--IRHKDSMDELFSH 3776

Query: 1326 EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRL 1385
               +     E ++          ++ +K E+L + ++ +     E+   L  A+    + 
Sbjct: 3777 RSEIFGTCGEEQK---------TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 3827

Query: 1386 -QTHADLNKWIS---AMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
             +T+ +L+ WI    A+  QL S  P  D   + +   +++++ + +   K  + +L   
Sbjct: 3828 WETYEELSPWIEETRALIAQLPS--PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 3885

Query: 1442 VPSMGEEGGDADLSIEKRF-------LDLLEPLGRRKKQLESSRAKLQISRDLED----- 1489
             P + E   +    +E+++         + E + +R   L+ + ++     +  D     
Sbjct: 3886 GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945

Query: 1490 ----ETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLV 1545
                E L    R+P    A+    +  ++  +  N++   E+    P  E + +RG++L+
Sbjct: 3946 LETLENLSSRLRMPPLIPAE----VDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001

Query: 1546 EAAE-----IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAW 1599
              ++     +  ++++++L  +   W+ ++  A  R  +  D  E A++++ D       
Sbjct: 4002 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4061

Query: 1600 IGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLAS-----RAQGLLSAG 1654
            I + +  V   E P  +   I   K+ +     +++    + +         A  + + G
Sbjct: 4062 IKDTQDIVHDLESPGIDPSII---KQQVEAAETIKEETDGLHEELEFIRILGADLIFACG 4118

Query: 1655 HPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQWISEKEL-V 1712
              E  ++ +   +++  +  L    +ER  KLE+ M    Q +     +  W+    + +
Sbjct: 4119 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4178

Query: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT--IAE 1770
             + P +G D + V    ++ ++F  E     Q  ++ +N   E ++     E     I E
Sbjct: 4179 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-QQIEMEKLNHQGELMLKKATDETDRDIIRE 4237

Query: 1771 WKDGLNEMWADLLELIDTRMQLL-AASYDLHRYFYTGAEILGLID--EKHRELPEDVGLD 1827
                L  +W +L E I  R   L  A   L ++ +   E++  +   E+  +    +  D
Sbjct: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297

Query: 1828 ASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQA 1887
                E     H   + ++      V+        L  + AG+ A +++++ + ++  W++
Sbjct: 4298 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4357

Query: 1888 LLDACAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYH 1945
            +L     R  QL  T  + + F S   D L  +  +  Q+   +    +  +    +  H
Sbjct: 4358 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417

Query: 1946 QGINAEIETRSKNFSACLELGE-SLLQRQHQASEEIREKLQQVMSRR-KEMNEKWEARWE 2003
              + ++++ + + ++  L+ G   LL R    S    E+   ++ ++   ++ K E R  
Sbjct: 4418 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477

Query: 2004 RLRMLLEVC-QFSRDASVAEAWL-IAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
            +L   L +  +F         WL +A++    +      +++V   I+ H+ F     + 
Sbjct: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH 4537

Query: 2062 AERFAALEK 2070
             ++   L++
Sbjct: 4538 RDQIIELDQ 4546



 Score =  107 bits (267), Expect = 1e-22
 Identities = 323/1777 (18%), Positives = 666/1777 (37%), Gaps = 244/1777 (13%)

Query: 391  DINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF 450
            D+ R  E   + + R    +    IRQ +LE +        A   T +   +   AQ   
Sbjct: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEM 1300

Query: 451  GYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLW 510
                   E ++   E +   TA + E    +E    +L++     Q+  T  KD  L+L 
Sbjct: 1301 -MKPGQAEDSRVLSEQLSQQTALFAE----IERNQTKLDQCQKFSQQYSTIVKDYELQLM 1355

Query: 511  SYL------QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVE 564
            +Y       Q+    RR+ L ++ A+ + F D+          +   L     +H+  + 
Sbjct: 1356 TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDL--------RTRYTALVTLTTQHVKYIS 1407

Query: 565  DLLQK----HKLMEADIAIQGDKVKAI---TAATLKFTEGKGYQPCDPQVIQDRISHLEQ 617
            D L++     K++E +     +KVK +    +   + T+GK       +      + LEQ
Sbjct: 1408 DALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQ 1467

Query: 618  CFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQR 677
              + LS     +K Q+ ++ +  + F      +   KEK+QI   L+             
Sbjct: 1468 --QVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLN------------A 1513

Query: 678  KHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKK 737
             +KA+ D   G    L+Q+         + Q  H            Q +Q         K
Sbjct: 1514 LNKAYHDLCDGSANQLQQL---------QSQLAH------------QTEQ---------K 1543

Query: 738  NLQDAENFFQFQGDADDLKAWLQDAHRLLSGED---VGQDEGATRALGKKHKDFLEELEE 794
             LQ  +N    Q   +DL +W+  A R L+G       QD  A +      KD  ++++ 
Sbjct: 1544 TLQKQQNTCHQQ--LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 1601

Query: 795  SRGVMEHLEQQAQGFPEEF------RDSPDVTHRLQALRELYQQVVAQADLRQQRLQEAL 848
                   + +  +GF EE       R+   +  +L   +E Y+ +  +  + Q+ L+EA+
Sbjct: 1602 RATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 1661

Query: 849  ---------------DLYTVFGETDACELWM-------GEKEKWLAEMEM---------- 876
                           +L     + DA   W+       G+    L  ME           
Sbjct: 1662 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 1721

Query: 877  PDTLEDLEVVQHRFDILDQEM-------KTLMTQIDGVNLAANS----LVESGHPRSREV 925
             DT +    V    + LD++        + L++Q     LA  S    L + GH  + E 
Sbjct: 1722 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781

Query: 926  KQ-YQDHLNTRWQAFQTLV----SERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
            +Q  Q  L    + + T +    +E ++       +  +  D +E   W+    K +E+ 
Sbjct: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841

Query: 981  KDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKE-----DIGQR 1035
               G     + ++ ++      DV + +  +  +    Q+++D     KE     +IG  
Sbjct: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 1901

Query: 1036 QKHLEELWQGLQQSLQGQEDLLGE-----VSQLQAFLQDLDDFQAWLSITQ---KAVASE 1087
             K   +       +L  +   LG      + Q   F    D  QAW+   +   + + S+
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961

Query: 1088 DMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--IQGQTDPEYLLLGQRLEG 1145
             +       ++ L     +++E+  HQ   +++++    +  I+G+  P++  + +  + 
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021

Query: 1146 LDTGWNALGRMWESRS-----------------HTLAQCLGFQEFQKDAKQA-------- 1180
            + + + +L      RS                  +L Q +G  E   + KQ         
Sbjct: 2022 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2081

Query: 1181 -EAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGS-----MENNRDKVLSPVDSGNKL 1234
             EA+ +N +          SLEA    + +F +   S     ++    +V    +     
Sbjct: 2082 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ 2141

Query: 1235 VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLL----RDNLELQNFLQNCQELTLWI 1290
              E      K+  + ++ E    K  +  +  S +L    + + ++ +F Q  QEL L +
Sbjct: 2142 QQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEM 2201

Query: 1291 NDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL---MDEKPQFT 1347
             D     Q  + D   +L  + L    F  +L  H+  ++N+  +  +L   + E+ +  
Sbjct: 2202 ED-----QQENLDTLEHLVTE-LSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2255

Query: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDP 1407
            +   ++L+   +L    Q   KE    +    +S     +  +L K I  ++  L  DD 
Sbjct: 2256 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS----MSAKELEKQIEHLKSLL--DDW 2309

Query: 1408 GKDLTSVNRMLAKLKRVEDQVN--VRKEELGELFAQVPSMGEEGG--------------D 1451
                T V  +  K   +E+ +      +  G+  + +PS+G   G               
Sbjct: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369

Query: 1452 ADLS-IEKRFLDLLEPLGRRKKQLESSRAKL-QISRDLEDETLWVEERLPLAQSAD---Y 1506
             D+S +  ++  L   L  R++ L++   ++ ++ ++      W+E +  + +S D    
Sbjct: 2370 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2429

Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ--RGQQLVEAAEIDCQDLEERLGHLQS 1564
             T  +TV+   + N+    E+  ++P+++ V +   G  +      + ++ ++    L S
Sbjct: 2430 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2489

Query: 1565 SWDRLREAAAGRLQRLRD-ANEAQQYYLDADEAEAWIGEQELYV-ISDEIPKDEEGAIVM 1622
             W+R  E    R ++L + A+    +     +   W+ E+EL + +   +  D       
Sbjct: 2490 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 2549

Query: 1623 LKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQ---VDKHYAGLKDVA 1679
             ++     +  E   +  +QL   AQG+L+          ++Q +   +++ +  L D  
Sbjct: 2550 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 2609

Query: 1680 EERKRKLE------NMYH--LFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRD 1730
              R  +++        Y   L  L  +   + Q +S +  +++ PE + Q  +  + +R 
Sbjct: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669

Query: 1731 KFRDFARETGAIGQERVDNVNAFI--ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788
                   E     Q   D ++  I  + L D       T+A    GL ++ AD +     
Sbjct: 2670 DLEQLDHEVKE-AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRI----N 2724

Query: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDA--STAESFHRVHTAFERELH 1846
            R+Q   AS    +  +   E+   +D+K  +  ++  + A     +S  + +  F++ L+
Sbjct: 2725 RLQAALASTQQFQQMFD--ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782

Query: 1847 L-LGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADK 1905
               G       +  + L +   GE+   +QN+  E+   W+ L    A R+++L D   K
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842

Query: 1906 FRFFSM-ARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLE 1964
             + +     DL+ W+E    ++       D   +E  +   + +  E+E R         
Sbjct: 2843 AQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNS 2902

Query: 1965 LGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEAR 2001
              + L+       + IR++   +      + E+ +A+
Sbjct: 2903 AADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 2939



 Score = 98.2 bits (243), Expect = 8e-20
 Identities = 313/1620 (19%), Positives = 627/1620 (38%), Gaps = 241/1620 (14%)

Query: 578  AIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSK 637
            A  G  +K I   T +    K  Q  D +V+ +++S     F E+       + +L+Q +
Sbjct: 1282 ACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER----NQTKLDQCQ 1337

Query: 638  RL-----------------WKFFWEMDEAESWIKEKEQIYSS-------LDYGKDLTSVL 673
            +                  +K F E  + +S  K +  + SS       +D     T+++
Sbjct: 1338 KFSQQYSTIVKDYELQLMTYKAFVESQQ-KSPGKRRRMLSSSDAITQEFMDLRTRYTALV 1396

Query: 674  ILQRKH-KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLA 732
             L  +H K   D LR L+   E++ +E             + +  +++V      +  LA
Sbjct: 1397 TLTTQHVKYISDALRRLEEE-EKVVEE-------------EKQEHVEKVKELLGWVSTLA 1442

Query: 733  AFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGK------KHK 786
                +N Q      + +   D  KA L+   ++LS E   + E  + A+        KH 
Sbjct: 1443 ----RNTQGKATSSETKESTDIEKAILEQ--QVLSEELTTKKEQVSEAIKTSQIFLAKHG 1496

Query: 787  DFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
              L E E+ +     + +Q     + + D  D +     L++L  Q+  Q +  Q+ LQ+
Sbjct: 1497 HKLSEKEKKQ-----ISEQLNALNKAYHDLCDGS--ANQLQQLQSQLAHQTE--QKTLQK 1547

Query: 847  ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQ-HRFDILD--QEMKTLMTQ 903
              +  T   + +    W+G+ E+ LA  +   T +DL  +Q ++ D+ D   +++   T 
Sbjct: 1548 QQN--TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATS 1605

Query: 904  IDGVNLAANSLVESGHPR--SREVKQYQDHLNTRWQAFQTLVSERR-------EAVDSAL 954
               V       +E    +   RE+   ++ L+   + ++ L  E R       EAV SAL
Sbjct: 1606 FATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 1665

Query: 955  RVHNY----CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG----------- 999
            +          +  E  K I      V S    G  L   +    +LSG           
Sbjct: 1666 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTT 1725

Query: 1000 ------------LERDVAAIQARVDAL----------ERESQQLMDSH-----PEQKEDI 1032
                        L++    ++AR   L           + +Q  +D H     PE+++ +
Sbjct: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785

Query: 1033 GQRQKHLEELWQ-GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPE 1091
             Q+   L+E +   L QS    + +     +LQ FLQD  +F++WL  ++K + +     
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845

Query: 1092 SLPEA-EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQT------DPEYL--LLGQR 1142
            S PE    LL++     +++  H+   + V  SG+KV+  +       +P  +  L+  +
Sbjct: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK 1905

Query: 1143 LEGLDTGWNALGRMWESRSHTLAQCLG-FQEFQKDAKQAEAILSNQEYTLAHL------E 1195
            L+     + AL          L   LG + +FQ  A   +A +   E  +  L       
Sbjct: 1906 LKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVAS 1965

Query: 1196 PPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDR 1255
             P  L+   A  ++ ++ L   +   +K+        ++  E       ++E    I   
Sbjct: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH 2025

Query: 1256 HRKNNEKAQEASVLLRDNL--------ELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
             +  +    E S LL+  +         L++ LQ+  E+   +  K ++S      +   
Sbjct: 2026 FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEAL 2085

Query: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQ-KLEALHRLWDELQA 1366
              N  LK      ++A  +  LE       + M+     TA V Q KL  + + +++L  
Sbjct: 2086 ATNMKLKQ-----DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2140

Query: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISA-----MEDQLR----SDDPGKDLTSVNRM 1417
              +EK   L        +L   A++ + +S      ME++ R     + P +D+T   + 
Sbjct: 2141 QQQEKESSLK-------KLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQ 2193

Query: 1418 LAKLK-RVEDQVNVRKEELGELFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLG 1468
            + +L   +EDQ    +E L  L   V  +   G   DL        ++ K F +L + + 
Sbjct: 2194 IQELNLEMEDQ----QENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVK 2249

Query: 1469 RRKKQLESSRAKLQISRDL-EDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527
             R+K   S + +L   R L      W++E        +   + + ++  ++  ++L ++ 
Sbjct: 2250 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2309

Query: 1528 LGHTPRVEDVLQRGQQL----VEAAEID------------------------CQDLEE-- 1557
                  VE++  +G  L    +E    D                        C+DL E  
Sbjct: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369

Query: 1558 -RLGHLQSSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWIGEQELYVISDEI--- 1612
              +  +   +++L      R + L+   N  ++ + +A+    W+  +E  + S +    
Sbjct: 2370 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2429

Query: 1613 PKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA--GHPEGEQIIRLQGQVDK 1670
            P   E      + +      +E     I+++     GLL       E E   ++Q +++ 
Sbjct: 2430 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2489

Query: 1671 HYAGLKDVAEERKRKLE-NMYHLFQLKRETDDLEQWISEKELVAS-SPEMGQDFDHVTLL 1728
             +    +V   R+R+LE +  HL   +     L  W+ EKEL+      +  D + +   
Sbjct: 2490 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 2549

Query: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD--GLNEMWADLLELI 1786
            + + +   +E  A  Q+      A    L   G    +T    K+   +N+ W +L + +
Sbjct: 2550 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 2609

Query: 1787 DTR-MQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFER-- 1843
            ++R  Q+  A     +Y     E+L  + EK R + + + + ++ +     V    E   
Sbjct: 2610 NSRSSQIDQAIVKSTQY----QELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665

Query: 1844 ----ELHLLGVQVQQFQDVATRLQTAYAGEK--AEAIQNKEQEVSAAWQALLDACAGRRT 1897
                +L  L  +V++ Q +   L +   GE+   + ++ + + V+   Q L D  A R  
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDEL-SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN 2724

Query: 1898 QL-VDTADKFRFFSMARDLLSWM-ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
            +L    A   +F  M  +L +W+ +   +Q +       +  ++  ++ ++     +   
Sbjct: 2725 RLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQH 2784

Query: 1956 SKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
            S ++   +  GESLL       E+  ++ +L ++ +  +E+++K   R  RL+  ++  Q
Sbjct: 2785 SGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQ 2844



 Score = 68.2 bits (165), Expect = 8e-11
 Identities = 346/1927 (17%), Positives = 696/1927 (36%), Gaps = 306/1927 (15%)

Query: 313  DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
            +LL+W+E+    L   ++ N L  V+ QL+      T       +E G+        + +
Sbjct: 591  ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHT-----SVEELGSSVKEARLYEGK 645

Query: 373  MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAA 432
            M  N    Y    GKL +   +  E+                 R   L+ L  +F  +A 
Sbjct: 646  MSQNFHTSYAETLGKLETQYCKLKETSS--------------FRMRHLQSL-HKFVSRAT 690

Query: 433  MRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN 492
                WL+E +      ++  + + + A +     +  +    ++  R+L+D A+ L  EN
Sbjct: 691  AELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLEN 750

Query: 493  YHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDM--LHSI--DWMDEIK 548
            +  ++ + A    +     ++++L     Q ++   A  + F D   L S   +  D IK
Sbjct: 751  HPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK 810

Query: 549  AHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQP------ 602
                S +    L  +EDLLQ     +  +      V ++   +    + K   P      
Sbjct: 811  -RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKN 869

Query: 603  -------CDPQVIQDRISHLEQCFEELSNM-----------------------------A 626
                   CD + I+  I   ++C  E ++                              A
Sbjct: 870  TISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDA 929

Query: 627  AGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQI-YSSLDYGKDLTSVLILQRKHKAFEDE 685
                +++EQS +     W     +  +  K  I ++ L    DL     L++   +   E
Sbjct: 930  IEMASRVEQSYQKVMALWH----QLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGE 985

Query: 686  ----LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDL-------AAF 734
                ++ L AH E   Q++   V        ++E  ++   A++  L             
Sbjct: 986  CHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETV 1045

Query: 735  CKKNLQDAENF-FQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
             K  + + +N   + +     +   +Q      +  D  QD  A R   ++H    E+L+
Sbjct: 1046 AKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQD-NALRIAEQEHTQ--EDLQ 1102

Query: 794  ESRGVMEHLEQQAQGFPEEFRDS---PDVTHRLQALRELYQQVVAQADLRQQRLQEALDL 850
            + R  ++ +  +   F  +   S   P +   L  L E    V   + +   +L+    +
Sbjct: 1103 QLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVI 1162

Query: 851  YTVFGETD----ACELWMGEKEKWLAEMEMPDT--------LEDLEVVQHRFDILDQEMK 898
                 + +      E+ + ++E  LA++   +         L D++     F +LD+E  
Sbjct: 1163 VRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEE-- 1220

Query: 899  TLMTQIDGVNLAANSLVESGHPRSREVKQYQD---HLNTRWQAFQTLVSERREAVDSALR 955
                 I    + A  +      R+ ++++YQ+    L  RW      +  R+  ++S   
Sbjct: 1221 -----IAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQE 1275

Query: 956  VHNYCVDCEET-SKWITDKTKVVESTKDLGRDLAGIIAIQ-RKLSGLERDVAAIQARVDA 1013
            V      C  T  KWI + T   E  K    + + +++ Q  + + L  ++   Q ++D 
Sbjct: 1276 VLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQ 1335

Query: 1014 LERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD- 1072
             ++ SQQ      + +  +   +  +E      QQ   G+   +  +S   A  Q+  D 
Sbjct: 1336 CQKFSQQYSTIVKDYELQLMTYKAFVES-----QQKSPGKRRRM--LSSSDAITQEFMDL 1388

Query: 1073 ---FQAWLSITQKAVA-SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVI 1128
               + A +++T + V    D    L E E+++++           Q+  ++VKE      
Sbjct: 1389 RTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE---------KQEHVEKVKEL----- 1434

Query: 1129 QGQTDPEYLLLGQRLEGLDTGW-NALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
                                GW + L R  + ++ T ++     + +K   + + +  ++
Sbjct: 1435 -------------------LGWVSTLARNTQGKA-TSSETKESTDIEKAILEQQVL--SE 1472

Query: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
            E T    +  ++++ ++  + K    L   E  + ++   +++ NK   +     D    
Sbjct: 1473 ELTTKKEQVSEAIKTSQIFLAKHGHKLS--EKEKKQISEQLNALNKAYHD---LCDGSAN 1527

Query: 1248 KVQLIEDR--HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEA 1305
            ++Q ++ +  H+   +  Q+        LE         E  L  +    T QD+S  + 
Sbjct: 1528 QLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQK 1587

Query: 1306 RNLHNKWLKHQ------AFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHR 1359
                 K L+        +F   +   EG++E       Q      + TAL  +KL     
Sbjct: 1588 NQSDLKDLQDDIQNRATSFATVVKDIEGFMEE-----NQTKLSPRELTAL-REKLHQAKE 1641

Query: 1360 LWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
             ++ LQ  T+   + L  A +               SA++ +       K+L    +   
Sbjct: 1642 QYEALQEETRVAQKELEEAVT---------------SALQQETEKSKAAKELAENKK--- 1683

Query: 1420 KLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRA 1479
            K+  + D V       G+L   +P M +  G    S+EK  LD  +        +  +  
Sbjct: 1684 KIDALLDWVTSVGSSGGQLLTNLPGMEQLSG---ASLEKGALDTTDGY----MGVNQAPE 1736

Query: 1480 KLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
            KL    D + E +    +  L+Q  ++    Q+ Q F+ ++        GH    E+   
Sbjct: 1737 KL----DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQH--------GHNLTPEE--- 1781

Query: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWD---RLREAAAGRLQRLRDANEAQQYYLDADEA 1596
              QQ+          L+++LG L+  +       EA   ++Q L+D  E Q++  D  E 
Sbjct: 1782 --QQM----------LQQKLGELKEQYSTSLAQSEAELKQVQTLQD--ELQKFLQDHKEF 1827

Query: 1597 EAWI--GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA- 1653
            E+W+   E+EL  +  +     E    +LKR       V  +  +++ +    Q +L   
Sbjct: 1828 ESWLERSEKELENM-HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886

Query: 1654 -GHPEGEQIIRLQGQV-DKHYAGLKDVAE-------------ERKRKLENMYHLFQLKRE 1698
                EG++   +   V DK    LKD  E                  L   YH FQ    
Sbjct: 1887 NSFKEGKEPSEIGNLVKDK----LKDATERYTALHSKCTRLGSHLNMLLGQYHQFQ--NS 1940

Query: 1699 TDDLEQWISE---------KELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
             D L+ W+            + VAS P + Q  + +   +    + A     +  E++  
Sbjct: 1941 ADSLQAWMQACEANVEKLLSDTVASDPGVLQ--EQLATTKQLQEELAEH--QVPVEKLQK 1996

Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL----AASYDLHRYFYT 1805
            V   I  +      +   + E  D +   +  L   +  R  LL    A S  +     +
Sbjct: 1997 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2056

Query: 1806 GAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA 1865
              + +G + E++ E  +   L +   +     +   ++++      ++  +++ TR    
Sbjct: 2057 LLQSIGEV-EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2115

Query: 1866 YAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS-MARDLLSWMESIIR 1924
                 A  +Q K  EVS  ++ L      + + L     +   F  ++  L  +ME+  R
Sbjct: 2116 ADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSR 2175

Query: 1925 QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLEL-------GESLLQRQHQ-A 1976
             + +  +P     +    +  Q +N E+E + +N      L       G +L   QHQ  
Sbjct: 2176 MLASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2233

Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
             + +R+   ++    KE  +   +  E+L       +F +     + WL   E  +   +
Sbjct: 2234 VQNLRKDFTELQKTVKEREKDASSCQEQLD------EFRKLVRTFQKWLKETEGSIPPTE 2287

Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEG 2096
               T  S ++L K+ E  +     WA +   +E+   +  K   +     E T P + +G
Sbjct: 2288 ---TSMSAKELEKQIEHLKSLLDDWASKGTLVEE---INCKGTSLENLIMEITAP-DSQG 2340

Query: 2097 ETAGEAP 2103
            +T    P
Sbjct: 2341 KTGSILP 2347



 Score = 54.3 bits (129), Expect = 1e-06
 Identities = 102/497 (20%), Positives = 193/497 (38%), Gaps = 63/497 (12%)

Query: 292  KVIDHAIE-------TEKMIEKYSGLASDLLTWIEQTITVLNSR-KFANSLTGVQQQLQA 343
            KV+  +IE         K  +++      L+ W+E   + L+S  + +N    ++ QL  
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLS- 4634

Query: 344  FSTYRTVEKPPKFQEK-GNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEA 402
                    K  +FQ+  G  + +  T     RA  +K   P D + + +       L E 
Sbjct: 4635 --------KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF------LGEV 4680

Query: 403  EYRRELALRNELIRQEKLEQ---LARRFDRKAAMRETWLSENQRLVAQDNFGY-DLAAVE 458
              + +      + RQ KLE+    + +F         WL + +  +A+D   + DL  V 
Sbjct: 4681 RDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVM 4740

Query: 459  AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
                 H+  + +       V+ L+   +EL + +  D   +  +   +   W  + +L  
Sbjct: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800

Query: 519  SRRQRLETTLALQKLFQDMLHS-IDWMDEIKAHL-LSAEFGKHLLEVEDLLQKHKLMEAD 576
            S++ RLE  L   ++F+D +H  ++W+ E +  L            ++ L+  HK  E  
Sbjct: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK--EFM 4858

Query: 577  IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQS 636
              ++  +V   +A  +         P     I+  I+ +   FEE+   A   + +LE +
Sbjct: 4859 KKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETA 4918

Query: 637  -KRLWKFFWEMDEAESWIKEKEQIYSSLD---YGKDLTSVLILQRKHKAFEDELRGLDAH 692
               L      ++E  +WI+  E      D     +++  V  L  +H+ F +E+      
Sbjct: 4919 LSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPD 4978

Query: 693  LEQI---------------FQEAHGMVARKQFGHP---------QIEA---RIKEVSAQW 725
            ++++               F E      RK    P         Q EA   RI ++SA+W
Sbjct: 4979 VDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARW 5038

Query: 726  DQLKDLAAFCKKNLQDA 742
             Q+  LA   ++ L DA
Sbjct: 5039 QQVWLLALERQRKLNDA 5055


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  298 bits (763), Expect = 4e-80
 Identities = 172/388 (44%), Positives = 234/388 (60%), Gaps = 15/388 (3%)

Query: 48  LADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGK 107
           +ADER+ VQKKTFTKW+N HL +V   + DLY+DLRDG  LI LLEVLSG+ LP+  KG+
Sbjct: 58  IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 116

Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ 167
           MR H L+NV  AL +LK ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  +
Sbjct: 117 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 176

Query: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKD 227
              E  SAK+ LLLW Q  T GY  +   NFT+ W+DG  FNA+IHK+RPDLID + +  
Sbjct: 177 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 234

Query: 228 SNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEG 287
            +   NLEHAF VAE+ +G+I LLDPEDV   +PDEKS+ITYV + Y  F K   +   G
Sbjct: 235 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK---VPEGG 290

Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTY 347
           + +G     A + E    +Y  + + L+ WI   +T ++ R F N+   ++     +  +
Sbjct: 291 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 345

Query: 348 RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRE 407
           +  E PPK  EK  ++ L   ++  +     K+     G   +DI + W  L  A   RE
Sbjct: 346 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 402

Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRE 435
            ALR E+ R E L+Q+A R  R + + E
Sbjct: 403 KALRPEVERLEMLQQIANRVQRDSVICE 430



 Score =  171 bits (432), Expect = 9e-42
 Identities = 321/1659 (19%), Positives = 676/1659 (40%), Gaps = 141/1659 (8%)

Query: 387  KLVSDINRAWESL-EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRL 444
            K +S ++  WE+L  +AE R          + E +  +A++F         WL+   +RL
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNR--------QLEGISVVAQQFHETLEPLNEWLTTIEKRL 3467

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
            V  +  G   + +E    +H+A+E D   + + +     + Q L+  +  + K +   K 
Sbjct: 3468 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3527

Query: 505  NILRLWSY-LQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEIKAHLLSAEFGKHLLE 562
            +  ++W   +QE   SR + L+  L   K+F +D +  ++W++E+   L       +  E
Sbjct: 3528 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3587

Query: 563  VEDLLQKH-KLMEADIAIQGDKVKAITA---ATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
                 Q   ++++ DI ++   V          LK T G      +  +IQD++  ++  
Sbjct: 3588 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGD-----EVLIIQDKLEAIKAR 3642

Query: 619  FEELSNMAAGRKAQLEQSKRLWKFFWEM-DEAESWIKEKEQIYSSLDY----GKDLTSVL 673
            +++++ ++      LEQ+ +L +      +E  +W+ + E    S +     G++ +   
Sbjct: 3643 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA- 3701

Query: 674  ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQLKDLA 732
              Q + K  + E +   A L+ + + +  ++    +     +E  + E + ++  + D  
Sbjct: 3702 --QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3759

Query: 733  AFCKKNLQDAE-NFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKHKDFLE 790
                + +  A     QF   AD   +W+ +  + L+S  D+  ++  T A  +  K F  
Sbjct: 3760 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3819

Query: 791  ELEESRGVMEHLEQQAQGF----PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
            E+   + +++ L +          EE + S  +  +L  + + Y  +      R  +L+ 
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLER 3877

Query: 847  ALDLYTVFGET-DACELWMGEKEKWLAEMEMPDT-LEDLEVVQHRFDILDQEMKTLMTQI 904
            A  L   F ET +    W+ E +  ++++  P    E L   Q     L + +      I
Sbjct: 3878 AQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3937

Query: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
            D +N     L+E        +++     +T +   +  V +R  A+D A+       D  
Sbjct: 3938 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD-- 3995

Query: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLS---GLERDVAAIQARVDALERESQQL 1021
            +  + +    ++VE  +      A +  I+ ++S    +  D+  +Q   + L++  +++
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 1022 MDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-QAFLQDLDDFQA 1075
            +       +DI  +  Q  L+++   W+ +   ++ +E  L +V +L + F  D      
Sbjct: 4056 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4115

Query: 1076 WLSITQKAVASEDMPESLPEAEQLLQQHAG-IKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134
             +  TQ  +   + P   P   +  Q+ A  I++EIDG Q+    V   G ++I    +P
Sbjct: 4116 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4175

Query: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAE-AILSNQEYTLAH 1193
            +  ++ + ++ L++ W++L + W+ R   L + +      +D  QA    +      LA 
Sbjct: 4176 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLAS 4235

Query: 1194 LEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-------- 1244
            + P    LE  +  I + + F       + ++         L+ +    SDK        
Sbjct: 4236 MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLM 4295

Query: 1245 -IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI--NDKLLTSQDVS 1301
             +K     +E+R      K + A       L L  F     EL  W+   + LL+ Q   
Sbjct: 4296 ELKLIWDSLEERIINRQHKLEGAL------LALGQFQHALDELLAWLTHTEGLLSEQKPV 4349

Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP-QFTALVSQKLEALHRL 1360
              + + +  +  KH     ++ +H+  +E ++  G  L++    +  + +  KLE L++ 
Sbjct: 4350 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4409

Query: 1361 WDELQATTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDP-------GKDLT 1412
            W  +   T+++ Q L  A R +        DL +W++  E  L +  P        K+  
Sbjct: 4410 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4469

Query: 1413 SVN-RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL-SIEKRFLDLLEPLGRR 1470
            +V+  + A  +  E+      ++  ++ A+ P   E   D D+ ++++++  +   L  R
Sbjct: 4470 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4529

Query: 1471 KKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
            K +LE +    ++    L+D   W+   E+ L +A        L TV   + +++   NE
Sbjct: 4530 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP--SLILDTVLFQIDEHKVFANE 4587

Query: 1527 ILGHTPRVEDVLQRGQQL-VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE 1585
            +  H  ++ ++ + G  L   + + D   ++  L  +QS W+++ +    R + L DA +
Sbjct: 4588 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4647

Query: 1586 -AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQRAV---------- 1633
             A+Q++    +   W+ E E  + S+ EI  D +     L +H   Q+++          
Sbjct: 4648 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4707

Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693
               GR++K+  S A   L       + +  L+ + D     +   + ER+ KLE    L 
Sbjct: 4708 NRTGRSLKEKTSLADDNLKL----DDMLSELRDKWDT----ICGKSVERQNKLEEA--LL 4757

Query: 1694 QLKRETDDLEQWIS-----EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVD 1748
               + TD L+  I      E +L    P  G D D V  L D  + F +E G    +R  
Sbjct: 4758 FSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELG----KRTS 4812

Query: 1749 NVNAF---IERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY----DLHR 1801
            +V A       LI+    +++ +      L+  W  +  L  ++   L A+     + H 
Sbjct: 4813 SVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHS 4872

Query: 1802 YFYTGAEILGLIDEK---HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
              +   E L   ++    H  LP+    D     +    H  F ++L     ++ +   +
Sbjct: 4873 VVHALLEWLAEAEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4928

Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA-----DKFRFFSMAR 1913
               +      +    I++    + A ++ +L A A +  Q + +A      K        
Sbjct: 4929 GDTVLAICHPDSITTIKHWITIIRARFEEVL-AWAKQHQQRLASALAGLIAKQELLEALL 4987

Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
              L W E+ +   + +  P+++  V+ L+  HQ    E+
Sbjct: 4988 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026



 Score =  157 bits (397), Expect = 1e-37
 Identities = 322/1813 (17%), Positives = 717/1813 (39%), Gaps = 209/1813 (11%)

Query: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
            ++ I   W++  +    RE  L+  L       + A ++  +      W+ + Q  + + 
Sbjct: 2872 LNTIKTNWDTFNKQVKERENKLKESL-------EKALKYKEQVETLWPWIDKCQNNLEEI 2924

Query: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
             F  D A  E +  K ++++ +   +   V  L + A  L      D++ +T    ++++
Sbjct: 2925 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2984

Query: 509  LWSYLQELLQSRRQRLETTLALQKLFQDML-----------HSIDWMDEIKAHLLSAEFG 557
                + E L S++  LE      K FQ++              +D  D + +   S ++ 
Sbjct: 2985 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3044

Query: 558  KHLLEVEDLLQ--KH-----KLMEADIAIQGDKVKAITAATLKF-TEGKGYQPCDPQV-- 607
              L   +  LQ  KH     K +  D+ ++    K  +   L+  T  + +     QV  
Sbjct: 3045 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3104

Query: 608  ------------------IQDRISHLEQCFEELSNMA-AGRKAQLEQSKRLWKFFWEMDE 648
                              I++  S   +  +EL +MA  GR A+  Q ++        + 
Sbjct: 3105 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQK--------ET 3156

Query: 649  AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
             ++++K+ E + +S D       +++   +      +L G+   LE + ++ + ++ R Q
Sbjct: 3157 IKAFLKKLEALMASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDRAQ 3213

Query: 709  FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
                Q+E  IK +   + +LK+ +      LQ AE   + QG               +  
Sbjct: 3214 AREEQVEGTIKRLEEFYSKLKEFSIL----LQKAEEHEESQGPVG------------MET 3257

Query: 769  EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD---VTHRLQA 825
            E + Q     +   K      EE+E  +G  + +    QG  +    S     + H L  
Sbjct: 3258 ETINQQLNMFKVFQK------EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3311

Query: 826  LRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLE 884
            +   ++ +  +   R  +LQEAL     F +  ++   WM + E+ +A  + P    + +
Sbjct: 3312 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA--EFK 3369

Query: 885  VVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EVKQYQDHLNTRWQAFQ 940
            VV+ +     +L + +    + ++ +      +  +  P  + ++ +    L++RW+A  
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3429

Query: 941  TLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
                 R   ++  ++    +    E  ++W+T   K + + + +G   + +     +   
Sbjct: 3430 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKA 3489

Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ-GLQQSLQGQEDLLG 1058
            LE D+      +       Q L      + +D+ Q +    ++W   +Q+    + +LL 
Sbjct: 3490 LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQ 3549

Query: 1059 E-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI-KDEIDGHQDS 1116
            + +   + F +D  +   WL+     ++   + +   E     Q    + +++I   + +
Sbjct: 3550 QALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQN 3609

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ---------- 1166
              +   +G ++++  T  E L++  +LE +   +  + ++    + TL Q          
Sbjct: 3610 VDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHS 3669

Query: 1167 -----CLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
                 C    + + +    E  +L  +E + A + P +  + A    +  +  L S+   
Sbjct: 3670 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA----KNNKALLDSLNEV 3725

Query: 1221 RDKVLSPV-----DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
               +L  V     +   K+VAE N    L SD I +KV+ I+             + +LR
Sbjct: 3726 SSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-------------AAILR 3772

Query: 1272 DNLELQNFLQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
                 Q F Q       WI +   KL++  D+  ++ +      ++ + F  E+  H+  
Sbjct: 3773 S----QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQ-KTFTMEILRHKDI 3827

Query: 1329 LENIDAEGKQLM----DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
            ++++   G ++M    +E+ Q    + +KL+ + + +D +     E+   L  A+S   +
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQ---SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3884

Query: 1385 L-QTHADLNKWISAMEDQL-RSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV 1442
              +T+ +L  W++  +  + +   P  +  ++ +   + +++ + +   K  + ++    
Sbjct: 3885 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3944

Query: 1443 PSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
            P + E       SI+++++        + E + +R   L+ + ++     D  D+ L   
Sbjct: 3945 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4004

Query: 1496 ERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA----- 1548
            ER+   L Q       ++ ++  + +N+ +  ++    P  E + QRG++++  +     
Sbjct: 4005 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4064

Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYV 1607
            +I  + ++++L  +   W+ +      R  +L D  E A++++ D       I + + ++
Sbjct: 4065 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4124

Query: 1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR--------AQGLLSAGHPEGE 1659
               E P  +   +       +QQ A E     I  L           ++ + + G P+  
Sbjct: 4125 RDLEDPGIDPSVV------KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4178

Query: 1660 QIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQW--ISEKELVASSP 1716
             + +   +++  +  L    ++R  KLE  M    Q +     +  W  I+  +L + SP
Sbjct: 4179 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4238

Query: 1717 EMGQDFDHVTLLRDKFRDFARET--GAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDG 1774
             +G D + V    ++ + F  E     I  ER+++    + + +    S+  T+ +    
Sbjct: 4239 -IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV-TEESDKHTVQDPLME 4296

Query: 1775 LNEMWADLLE-LIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPED--VGLDASTA 1831
            L  +W  L E +I+ + +L  A   L ++ +   E+L  +      L E   VG D    
Sbjct: 4297 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356

Query: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
            E     H   + ++      V+        L  + AGE+A  +QNK + ++  WQ +L+ 
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416

Query: 1892 CAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYHQGIN 1949
               R+ QL     + + F     DL  W+    R +   +    +  + +  +  H  + 
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4476

Query: 1950 AEIETRSKNFSACLELGESLLQRQHQASE--------EIREKLQQVMSRRKEMNEKWEAR 2001
            A  E + + + + ++ G+ +L R  +++E         ++EK + V ++  E   K E  
Sbjct: 4477 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE-- 4534

Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYL-ASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
             E L + +E   F         WL   E  L  +      +D+V   I  H+ F     S
Sbjct: 4535 -EALNLAME---FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4590

Query: 2061 WAERFAALEKPTT 2073
              E+   L+K  T
Sbjct: 4591 HREQIIELDKTGT 4603



 Score =  155 bits (393), Expect = 3e-37
 Identities = 308/1553 (19%), Positives = 632/1553 (40%), Gaps = 124/1553 (7%)

Query: 606  QVIQDRISHLEQCFEELSNMAAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLD 664
            Q ++  +  +   ++ L+   A R AQL+++     +F   ++   SW+ + E++ ++  
Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362

Query: 665  YGKDLTSVLILQ-RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHP-QIEARIKEVS 722
                   V+  Q ++ K  +  L    + +E I +E   +    +     +I  ++  + 
Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3422

Query: 723  AQWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAH-RLLSGEDVGQDEGATRA 780
            ++W+ L + A    + L+      Q F    + L  WL     RL++ E +G        
Sbjct: 3423 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3482

Query: 781  LGKKHKDFLEELEESRGVMEHLEQ-----QAQGFPEEFRDSPDVTHRLQALRELYQQVVA 835
               +HK   +++       +HL Q     Q+        D   V  +L   +  Y ++  
Sbjct: 3483 QIAQHKALEDDIINHN---KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539

Query: 836  QADLRQQRLQEALDLYTVFGETDACEL--WMGEKEKWLAEMEMPD-TLEDLEVVQHRFDI 892
            ++  R + LQ+AL    +FGE D  EL  W+ E    L+++ + D + E L   Q    +
Sbjct: 3540 KSHSRSELLQQALCNAKIFGE-DEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3598

Query: 893  LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNT---RWQAFQTLVSERREA 949
            L +++      +D   L    L++       EV   QD L     R++    L ++  + 
Sbjct: 3599 LQEDILLRKQNVDQALLNGLELLKQ--TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656

Query: 950  VDSAL----RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKL--SGLERD 1003
            ++ AL    R+H+     EE   W+ DK +V E      + L G  A Q ++    L+++
Sbjct: 3657 LEQALQLARRLHS---THEELCTWL-DKVEV-ELLSYETQVLKGEEASQAQMRPKELKKE 3711

Query: 1004 VAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQSL-QGQEDLLGEVS 1061
                +A +D+L   S  L++  P   +E + +      E ++ +  ++ Q  E++   + 
Sbjct: 3712 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3771

Query: 1062 QLQAFLQDLDDFQAWLSITQKAVAS-EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRV 1120
            + Q F Q  D   +W++ T+K + S  D+     +    LQ       EI  H+D    +
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3831

Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGF-QEFQKDAKQ 1179
             +SG K++   ++ E   + ++L+ +   ++ + ++   R   L +      +F +  ++
Sbjct: 3832 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3891

Query: 1180 AEAILSNQEYTLAHLEPP----DSLEAAEAGIRKFEDFLGSMENNRDKV---------LS 1226
                L+  +  ++ L  P    ++L   +   R+  + +   + + DK+         LS
Sbjct: 3892 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3951

Query: 1227 PVDSGN---KLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNC 1283
            P +  +   K VA   LYS +IKE V+          ++A      +  + +  + +   
Sbjct: 3952 PGEGFSIQEKYVAADTLYS-QIKEDVK----------KRAVALDEAISQSTQFHDKIDQI 4000

Query: 1284 QELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM--- 1340
             E    I ++L     +S  E   +  +  +++    ++   +   E +   G++++   
Sbjct: 4001 LESLERIVERLRQPPSISA-EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4059

Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEK-TQHLSAARSSDLRLQTHADLNKWISA 1397
               +K      V  KL+ +  +W+ +    +E+  + L     ++     H  L   I  
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4119

Query: 1398 MEDQLRS-DDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSI 1456
             +D +R  +DPG D + V +     + + ++++  +EEL  +      +    G+ D  I
Sbjct: 4120 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4179

Query: 1457 EKRFLDLLEPL---------GRRKKQLESSRAKLQISRDLEDETLWVE-ERLPLAQSADY 1506
             K+ +D L             R  K  E+ +A +Q    L+    WV+     LA  +  
Sbjct: 4180 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4239

Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQS 1564
            GT+L+TV+  +++ +  ++E       +E +  + + L++    E D   +++ L  L+ 
Sbjct: 4240 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299

Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAEAWIGEQELYVISDEIPK--DEEGAIV 1621
             WD L E    R  +L  A  A   +  A DE  AW+   E  ++S++ P   D +   +
Sbjct: 4300 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE-GLLSEQKPVGGDPKAIEI 4358

Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDV 1678
             L +H   Q  V  +   ++ +      L+ +    GE+   LQ +++   + +  + + 
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS--AGEEASNLQNKLEVLNQRWQNVLEK 4416

Query: 1679 AEERKRKLENMYHLFQ-LKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDF 1735
             E+RK++L+      +    E +DL+QW++  E+ L+AS P  G        L     + 
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL-----NV 4471

Query: 1736 ARETGAIGQERVDNVNAFIER----LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
              E  A  + + +   + +++    L     S    I +  + L E W  +   ++ R  
Sbjct: 4472 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4531

Query: 1792 LLAASYDLHRYFYTGAE-ILGLIDEKHREL--PEDVGLDASTAESFHRVHTAFERELHLL 1848
             L  + +L   F+   +  +  + +  + L       L   T       H  F  E++  
Sbjct: 4532 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4591

Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
              Q+ +     T L+     +    I+N    V + W+ ++     R   L D   + + 
Sbjct: 4592 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4651

Query: 1909 FSMA-RDLLSWMESIIRQIETQ-ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELG 1966
            F  A   L+ W+E   + ++++ E   D   ++  +  H+     +  +   +      G
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711

Query: 1967 ESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAE 2022
             SL ++   A + +  KL  ++S   E+ +KW+       ER   L E   FS   + A 
Sbjct: 4712 RSLKEKTSLADDNL--KLDDMLS---ELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766

Query: 2023 A----WLIAQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
                 WL   EP LA     H  +D V  LI  H+AF+K          AL++
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819



 Score =  149 bits (375), Expect = 4e-35
 Identities = 358/1838 (19%), Positives = 731/1838 (39%), Gaps = 212/1838 (11%)

Query: 359  KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE 418
            K   EVLL    S + A N    T  D  +V       +S+ E   + ++ L   L  Q+
Sbjct: 2050 KKTAEVLLDARGSLLPAKNDIQKTLDD--IVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2107

Query: 419  KLEQLARRFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEER 477
             L+++             W+      L  Q     +  A++    K+  +E D A  +  
Sbjct: 2108 GLDEML-----------DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2156

Query: 478  VRALEDLAQE-LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
            + A+ +  ++ +E  +      + A+  ++   +S      +    ++E      +LF++
Sbjct: 2157 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2216

Query: 537  MLHSIDWMDEIKAHLLSAEF--GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
            +   +    E K   L+     GK + E+   +Q+         ++  K   +  + LK 
Sbjct: 2217 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQE----STSEFLEHKKHLEVLHSLLKE 2272

Query: 595  TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKFFWEMDEAESWI 653
                G  P D  ++ ++ ++L + F+E+ +    +K  +    ++L  F   +   +SWI
Sbjct: 2273 ISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWI 2331

Query: 654  KEK-------EQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------LEQIFQE 699
            KE        +  + + D GK L     LQ K      E++ ++         +  +   
Sbjct: 2332 KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP 2391

Query: 700  AHGMVARKQFGH--------------------PQIEARIKEVSAQWDQL----KDLAAFC 735
            A  + A K  G                       I+  + ++S  ++ L    KD  A  
Sbjct: 2392 AKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAEL 2451

Query: 736  KKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEGATRALGKKHKDFLEEL 792
               L   +   + Q ++  +  WLQ  ++  +         D  A +   +++K F  EL
Sbjct: 2452 NTKLSKLQ---KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2508

Query: 793  EESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALD 849
            +++   ++ L+ +     EE  D+P+     Q L E+   +Q++      RQQ+L+E+ +
Sbjct: 2509 KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSN 2568

Query: 850  LYTVFGETDA-CELWMGEKEKWLAEMEMPDTLED--LEVVQHRFDILDQEMKTLMTQIDG 906
              T F   +A  + W+ EKE  ++ +  P +++   L   + +  IL QE  T   Q + 
Sbjct: 2569 NLTQFQTVEAQLKQWLVEKELMVSVLG-PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2627

Query: 907  VNLAANSLVES-GHPRSRE--VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDC 963
            +  A   ++   G   S    VK+    +  +W +    +S+R + +D A+         
Sbjct: 2628 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAI--------- 2678

Query: 964  EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
             +++++ +    + +   DL   L+  +A+      + + +   Q     +++E +Q+  
Sbjct: 2679 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2738

Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQG--------QEDLLGEVSQLQA-------FLQ 1068
            +     ED+    K  E L   L + L+G        ++     V  LQ+       F Q
Sbjct: 2739 AQA-LCEDLSALVKE-EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2796

Query: 1069 DLDDFQAWLSITQKAVASEDMPES--LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEK 1126
               DFQAWL  T+K   ++  P S  L   E L++ H      +      Y++    GE 
Sbjct: 2797 MSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN 2855

Query: 1127 VIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI--- 1183
            ++      E   L  +L  + T W+   +  + R + L + L  ++  K  +Q E +   
Sbjct: 2856 LLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL--EKALKYKEQVETLWPW 2913

Query: 1184 -------LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NNRDKVLSPVDSGNK 1233
                   L   ++ L   E  +S+   ++  ++ +   G +E   N  + +LS  +   +
Sbjct: 2914 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 2973

Query: 1234 LVAEGNLYSDKIKEKVQLI-EDRHRKN---NEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
            +V + N     + +KV ++ E  H K        Q+       + E +  LQ C +  L 
Sbjct: 2974 VVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ-CAKEQLD 3029

Query: 1290 INDKL----LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ 1345
            I+D L     +++ ++  + +    + LKHQ  +A+  + +  +E  D++G         
Sbjct: 3030 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--------- 3080

Query: 1346 FTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS 1404
             T+ V  ++E + +    L     EK   L          Q T  ++    +  +D+L S
Sbjct: 3081 -TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDS 3139

Query: 1405 DDP-GKDLTSVNR----MLAKLKRVE----DQVNVRKEELGELFAQVPSMGEEGGDADL- 1454
              P G+D  ++ +    + A LK++E       N  K     L  +  S    G   DL 
Sbjct: 3140 MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLE 3199

Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKLQ--ISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
            ++ K+   LL+    R++Q+E +  +L+   S+  E   L  +           G   +T
Sbjct: 3200 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3259

Query: 1513 VQLFMKKNQTLQ-NEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRL 1569
            +   +   +  Q  EI     + +DV   GQ L+++A      Q LE  L  + + W  L
Sbjct: 3260 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3319

Query: 1570 REAAAGRLQRLRDANEAQQYYLDADEA-EAWIGEQELYVISDEIPKDEEGAI-VMLKRHL 1627
             +  A R  +L++A      + DA E+  +W+ + E  V + + P  E   +   ++   
Sbjct: 3320 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3379

Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGE-QIIRLQGQVDKHYAGLKDVAEERKRKL 1686
              QR ++D    ++ +    + + +   P  + +I++    +D  +  L + AE R R+L
Sbjct: 3380 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3439

Query: 1687 ENMYHLFQLKRET-DDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
            E +  + Q   ET + L +W++  EK LV   P        +     K  +   +  A+ 
Sbjct: 3440 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP--------IGTQASKLEEQIAQHKAL- 3490

Query: 1744 QERVDNVNAFIERLIDAGHS-------EAATIAEWKDGLNEMW-ADLLELIDTRMQLLAA 1795
            ++ + N N  + + +  G S       E   + + K   +++W  ++ E   +R +LL  
Sbjct: 3491 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3550

Query: 1796 SYDLHRYF-YTGAEILGLIDEKHRELPEDVGLDASTAESFHRVH--TAFERELHLLGVQV 1852
            +    + F     E++  ++E H +L +    D ST   + +       + ++ L    V
Sbjct: 3551 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3610

Query: 1853 QQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-----R 1907
             Q       L     G++   IQ+K + + A ++ +        T +  T ++      R
Sbjct: 3611 DQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL----STDVAKTLEQALQLARR 3666

Query: 1908 FFSMARDLLSWMESI---IRQIETQE-RPRDVSSVELLMKYHQGINAEIETRSKNFSACL 1963
              S   +L +W++ +   +   ETQ  +  + S  ++  K       E++  +KN  A L
Sbjct: 3667 LHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-------ELKKEAKNNKALL 3719

Query: 1964 ----ELGESLLQR-QHQASEEIREKLQQVMSRRKEMNEKWEARWERL-RMLLEVCQFSRD 2017
                E+  +LL+    +A E + + + +   R + +++    + E +   +L   QF + 
Sbjct: 3720 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3779

Query: 2018 ASVAEAWLIAQEPYLAS-GDFGHTVDSVEKLIKRHEAF 2054
            A    +W+   E  L S GD     D     ++  + F
Sbjct: 3780 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3817



 Score =  129 bits (325), Expect = 2e-29
 Identities = 389/2030 (19%), Positives = 780/2030 (38%), Gaps = 278/2030 (13%)

Query: 277  FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSG--LASDLLTWIEQTITVLNSRK---FA 331
            FSK K+ + E     + +  A++T ++     G  +  +    +E+ +  L       F+
Sbjct: 1500 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1559

Query: 332  NSLTGVQQQLQAFSTYRTV--------EKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTP 383
             SL    +QLQ   T   V        E+  +++EK      L T        +Q+ +  
Sbjct: 1560 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1615

Query: 384  HDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
             DG +              E ++  + + EL  Q+ ++  A+         E +L EN  
Sbjct: 1616 GDGTV--------------ELKKYQSKQEEL--QKDMQGSAQALAEVVKNTENFLKENGE 1659

Query: 444  LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
             ++Q++       +  AK K E +       ++ +  +   A + E E     K++   K
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1719

Query: 504  DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH--------SIDWMDEIKAHLLSAE 555
              I  L  +L  +   +      T   Q + Q+  H        +I   DE+  +LL  +
Sbjct: 1720 TKIENLLDWLSNV--DKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1777

Query: 556  FGKHLLEVEDLL----QKHKLMEADIAIQGDKVKAIT--AATLKFTEGKGYQPCDPQVIQ 609
                +   ++ L    QK K     I  Q   V   T  A  L   +G+   P + + +Q
Sbjct: 1778 VDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ 1837

Query: 610  DRISHLEQCFEE-LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYG-K 667
              +  L+  +E  L+      K      + L KF  +  E E W+++ EQ   +L+ G  
Sbjct: 1838 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897

Query: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQI------FQEAHGMVARKQFGHPQIEARIKEV 721
            D+  ++   ++ K+F +++      L  I        EA    +++  G     A  +EV
Sbjct: 1898 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1957

Query: 722  SAQWDQLKD----LAAFCK---KNLQDAENFFQFQGDAD-DLKAWLQDAHRLLS---GED 770
              + D   D    L + C     NL+D  + +Q   DA   L A LQ      S    E 
Sbjct: 1958 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2017

Query: 771  VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE----FRDSPDVTHRLQAL 826
            +  D    +   ++ K    ++   +  +E L++ A+   +          D+   L  +
Sbjct: 2018 IAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI 2077

Query: 827  RELYQQVVAQADLRQQRLQEALD-LYTVFGETDACELWMGEKEKWLAEM-EMPDTLEDLE 884
               Y+ +    + R ++LQ  L    +V    D    WMG  E  L E  ++P     L+
Sbjct: 2078 VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ 2137

Query: 885  VVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP----------------------RS 922
             +  +  +L+Q++    + I+ +N      +E+  P                      + 
Sbjct: 2138 DIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKH 2197

Query: 923  REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV-ESTK 981
            +E     + L T+ + F+ L  + +  +++  +      + +   K +T+ ++ + EST 
Sbjct: 2198 KETLAKMEELKTKVELFENLSEKLQTFLETKTQA---LTEVDVPGKDVTELSQYMQESTS 2254

Query: 982  DL---GRDLAGIIAIQRKLS--GLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ 1036
            +     + L  + ++ +++S  GL  D A +  + + L ++ +++ D+  E+KE +   Q
Sbjct: 2255 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQ 2314

Query: 1037 KHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
            + L + +Q L +SL+                  + +    + I Q +  +ED+ +SL + 
Sbjct: 2315 EQL-DAFQVLVKSLKSW----------------IKETTKKVPIVQPSFGAEDLGKSLEDT 2357

Query: 1097 EQLLQQHAGIKDEIDGHQDS----------------YQRVKESGEKVIQGQ---TDPEYL 1137
            ++L ++ +    EI    +S                     +SG  V+ G+   T+ E  
Sbjct: 2358 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2417

Query: 1138 LLGQRLEG-------LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS----- 1185
               + L         +  G+  LG + + +   L   L   + QK  +++ A++      
Sbjct: 2418 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL--SKLQKAQEESSAMMQWLQKM 2475

Query: 1186 NQEYTLAHLEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEG--NLYS 1242
            N+  T     P P   EA +  + + + F   ++ N +KV    D   +L+ E      +
Sbjct: 2476 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2535

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQ--- 1298
             + K+ +  I+ + ++ N+   +    L ++   L  F     +L  W+ +K L      
Sbjct: 2536 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2595

Query: 1299 DVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD---EKPQFTALVSQKLE 1355
             +S D    L+ +  + Q  + E A+ +   E + A G+ ++    E P    +V ++L 
Sbjct: 2596 PLSID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2654

Query: 1356 ALHRLWDELQATTKEK-----------TQHLSAARSSDLRLQTHADL-NKWISAMEDQLR 1403
            A+ + WD L     ++           TQ+ S  RS   +L   +DL NK  S++     
Sbjct: 2655 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL---SDLDNKLSSSLAVSTH 2711

Query: 1404 SDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLS-----IEK 1458
             D   + L +  +M  ++++ + Q+ V +    +L A V    EE   A+LS     I K
Sbjct: 2712 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK---EEYLKAELSRQLEGILK 2768

Query: 1459 RFLDLLEPLGRRKKQLESSRAK----LQISRDLEDETLWVE-ERLPLAQSADYGTNLQTV 1513
             F D+ +      + L+S+ A      Q+SRD +    W++ ++    +S      L  +
Sbjct: 2769 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVL 2825

Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQ-LVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
            +  +K ++     +   +   E  +  G+  L++    +   L+ +L  ++++WD   + 
Sbjct: 2826 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2885

Query: 1573 AAGRLQRLRDANE-AQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRH 1626
               R  +L+++ E A +Y    +    WI +     +E+    D  P + E +I  LK  
Sbjct: 2886 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLK-- 2941

Query: 1627 LRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKL 1686
               Q+ ++ +   ++ L + A  LLS    + E +      + +    + +    +K  L
Sbjct: 2942 -SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3000

Query: 1687 ENMYHLFQLKRET--DDLEQWISEKELVASSPEMGQDF---DHVTLLRDKFRDFARETGA 1741
            ENM   F+  +E   +   Q    KE +     +G       ++T+L+ + +        
Sbjct: 3001 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060

Query: 1742 IGQERVDNVNAFIERLIDAGHS----EAATIAEWKDGLNEMWADLLELIDTRMQLLAASY 1797
            +   +    +  +E     G S    +  TIA+    L++   +    ++T++Q +    
Sbjct: 3061 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3120

Query: 1798 DLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELH-LLGVQVQQFQ 1856
            +  R  +  ++     DE     P  VG DA T +       AF ++L  L+       +
Sbjct: 3121 NTIREMF--SQFAEFDDELDSMAP--VGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3176

Query: 1857 DVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMARDL 1915
                 L T         I+   + +S     LLD    R  Q+  T  +   F+S  ++ 
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3236

Query: 1916 LSWMESIIRQIETQ----ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
               ++      E+Q         ++    + K  Q    EIE           LG+ L+Q
Sbjct: 3237 SILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQ 3294

Query: 1972 --RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQE 2029
               +  +++ +   L  V +R K +N+K   R  +L+  L  C                 
Sbjct: 3295 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC----------------- 3337

Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASW---AERFAALEKPTTLELK-------ER 2079
                    G   D++E L+           SW    E   A +KP + E K       E+
Sbjct: 3338 --------GRFQDALESLL-----------SWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3378

Query: 2080 QIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESL 2129
            ++ +R  ++     E  +  GE   +     ++   +   S L S WE+L
Sbjct: 3379 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3428



 Score =  102 bits (254), Expect = 4e-21
 Identities = 315/1749 (18%), Positives = 686/1749 (39%), Gaps = 177/1749 (10%)

Query: 387  KLVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRFDRKAAMRETWLSENQRLV 445
            K ++DI+  +E L        L L++++     KL +L +  +  +AM + WL +  +  
Sbjct: 2428 KDMTDISHGYEDLG-------LLLKDKIAELNTKLSKLQKAQEESSAMMQ-WLQKMNKTA 2479

Query: 446  A---QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN--YHDQKRIT 500
                Q     D  AV+   +++++ E +      +V+ L+D   EL +EN    +  R  
Sbjct: 2480 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2539

Query: 501  ARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFGKH 559
                 I   W  L +L   R+Q+LE +      FQ +   +  W+  ++  L+ +  G  
Sbjct: 2540 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPL 2597

Query: 560  LLEVEDL---LQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
             ++   L    Q+ +++  + A +  + + +TAA        G  P    +++++++ + 
Sbjct: 2598 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2657

Query: 617  QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
            Q ++ L+   + R   ++Q+        +  + +S ++      S LD    L+S L + 
Sbjct: 2658 QKWDSLTGQLSDRCDWIDQA------IVKSTQYQSLLRSLSDKLSDLD--NKLSSSLAVS 2709

Query: 677  RKHKAFEDELRGLDAHLEQIFQEAH------------GMVARKQFGHPQIEARIKEVSAQ 724
                A   +L       ++I QE                + ++++   ++  +++ +   
Sbjct: 2710 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2769

Query: 725  WDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQ-DAHRLLSGEDVGQDEGATRALG 782
            +  ++  A    ++LQ A  +  QFQ  + D +AWL            +        +L 
Sbjct: 2770 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLI 2829

Query: 783  KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ--ALRELYQQVVAQADLR 840
            K HKDF + L     + E    + +    + + S     +LQ   ++  +     Q   R
Sbjct: 2830 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2889

Query: 841  QQRLQEALDLYTVFGE-TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKT 899
            + +L+E+L+    + E  +    W+ + +  L E++      + E    +   L +EM  
Sbjct: 2890 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2949

Query: 900  LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNY 959
                ++ +N  ANSL+         V      L  +       +  ++  +++  +    
Sbjct: 2950 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK- 3008

Query: 960  CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK----LSGLERDVAAIQARVDALE 1015
              + +E SK    + +  +   D+  D  G  A   K    L   ++ + A++ +VD  +
Sbjct: 3009 --EFQEVSKESKRQLQCAKEQLDI-HDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3065

Query: 1016 RESQQLMDSHPEQK--EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDF 1073
            R +Q L+    + K   D+  + + + +    L Q +        + S L+  LQ +  F
Sbjct: 3066 RLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD------EKCSFLETKLQGIGHF 3119

Query: 1074 QAWL--SITQKAVASEDMPESLP---EAEQLLQQHAGIK---DEIDGHQDSYQRVKESGE 1125
            Q  +    +Q A   +++    P   +AE L +Q   IK    +++    S     ++ +
Sbjct: 3120 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3179

Query: 1126 KVI-QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCL-GFQEFQKDAKQAEAI 1183
             ++   +T P+ + + + LE L    N L    ++R   +   +   +EF    K+   +
Sbjct: 3180 MMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSIL 3239

Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
            L   E    H E    +      I +  +     +    + L         + +G + S 
Sbjct: 3240 LQKAE---EHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA 3296

Query: 1244 KIKEKVQLIED-------RHRKNNEK-AQEASVLLRDNLELQNFLQNCQELTLWIND--K 1293
                  Q +E        R +  N+K AQ A+ L    L    F    + L  W+ D  +
Sbjct: 3297 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3356

Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL-MDEKPQFTALVSQ 1352
            L+ +Q     E + +  +  + +     L   +  +E I  EG+++    +P     + +
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3416

Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTH---ADLNKWISAMEDQLRSDDP-G 1408
            +L  L   W+ L    K +T++      S +  Q H     LN+W++ +E +L + +P G
Sbjct: 3417 QLSLLDSRWEAL--LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3474

Query: 1409 KDLTSVNRMLAKLKRVEDQVNVRKEELGEL--FAQVPSMGEEGGDADLSIEKR------F 1460
               + +   +A+ K +ED +    + L +     Q   +     D D+   K       +
Sbjct: 3475 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3534

Query: 1461 LDLLEPLGRRKKQLESSRAKLQISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLF 1516
            +++ E    R + L+ +    +I  + E E + W   V ++L      DY T     Q  
Sbjct: 3535 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ-- 3592

Query: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEID-CQDLEERLGHLQSSWDRLREAAAG 1575
              + + LQ +IL     V+  L  G +L++    D    ++++L  +++ +  + + +  
Sbjct: 3593 QSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3652

Query: 1576 RLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISDE--IPKDEEGAIVM-----LKRHL 1627
              + L  A + A++ +   +E   W+ + E+ ++S E  + K EE +        LK+  
Sbjct: 3653 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3712

Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
            +  +A+ D   ++ +++S    L+     EG  + ++  + ++ Y  + D   ++  +++
Sbjct: 3713 KNNKALLD---SLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEID 3767

Query: 1688 NMYHLFQLKRETDDLE-QWISEKE-LVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQE 1745
                  Q   +  D E  WI+E E  + S  ++  + D  +      + F  E       
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME------- 3820

Query: 1746 RVDNVNAFIERLIDAGHS-EAATIAEWKDGLNEMWADLLELIDT--------RMQLLAAS 1796
             +      I+ L+ +GH    A   E K  + +    +L+  DT         +QL  A 
Sbjct: 3821 -ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3879

Query: 1797 YDLHRYFYTGAEILGLIDEKH---RELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
              +++++ T  E+   + E      +LP    L+  T       H      +      + 
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAP-ALEYETLRQQQEEHRQLRELIAEHKPHID 3938

Query: 1854 QFQDVATRLQTAYAGE---------KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD 1904
            +      +L     GE          A+ + ++ +E        LD    + TQ  D  D
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3998

Query: 1905 KFRFFSMARDLLSWMESIIRQIETQERPRDVSS----VELLMKYHQGINAEIETRSKNFS 1960
            +             +ES+ R +E   +P  +S+    ++  +  ++ ++ ++E     + 
Sbjct: 3999 QI------------LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYE 4046

Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
               + GE ++ R     ++I  K  Q      +  ++    WE +  L+E     R+A +
Sbjct: 4047 TLKQRGEEMIARSGGTDKDISAKAVQ------DKLDQMVFIWENIHTLVE----EREAKL 4096

Query: 2021 AEAWLIAQE 2029
             +   +A++
Sbjct: 4097 LDVMELAEK 4105



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 157/754 (20%), Positives = 293/754 (38%), Gaps = 78/754 (10%)

Query: 307  YSGLASDLLTWIEQTIT-VLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
            + G   DL  W+  T   +L S+         ++QL        +E    F+ K      
Sbjct: 4434 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH-----MEVCAAFEAKEETYKS 4488

Query: 366  LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLAR 425
            L     +M A   K    +  + ++++   WES+E     R+  L   L        LA 
Sbjct: 4489 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL-------NLAM 4541

Query: 426  RFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDL 484
             F         WL++  Q L         L  V     +H+    +  ++ E++  L+  
Sbjct: 4542 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4601

Query: 485  AQELEKENYHDQKRITARKDNIL----RLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
               L+   Y  QK+      N+L      W  + + L  R + L+      K F +    
Sbjct: 4602 GTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4658

Query: 541  I-DWMDEIKAHLLSA-EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGK 598
            + +W++E +  L S  E      +++  L +HK  +  +  +   V   T  T +  + K
Sbjct: 4659 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK-HSVYDTTNRTGRSLKEK 4717

Query: 599  GYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAE-SWIKEKE 657
                 D   + D +S L   ++ +   +  R+ +LE++      F +  +A   W+   E
Sbjct: 4718 TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4777

Query: 658  -QIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEA 716
             Q+        D+  V+ L   HKAF+ EL    + ++ + + A  ++   +     ++ 
Sbjct: 4778 PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV 4837

Query: 717  RIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHRLLSGEDV-GQD 774
            +++E+S +W+ +  L+   +  L+ A     +F      L  WL +A + L    V   D
Sbjct: 4838 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4897

Query: 775  EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD----VTHRLQALRELY 830
            E A R L  +HK+F+++LEE R  +   +    G        PD    + H +  +R  +
Sbjct: 4898 EDALRTLIDQHKEFMKKLEEKRAELN--KATTMGDTVLAICHPDSITTIKHWITIIRARF 4955

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME---MPDTLEDLEVV 886
            ++V+A A   QQRL  AL       E  +A   W+   E  L + +   +P  +E+++ +
Sbjct: 4956 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5015

Query: 887  QHRFDILDQEMKTLMTQIDGVN-----------------------------LAANSLVES 917
                    +EM      +D V                                A+SL  S
Sbjct: 5016 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5075

Query: 918  GHPRSREVKQYQDHLN-TRWQAFQTLVSERREAVDSAL-------RVHNYCVDC--EETS 967
            G     E K  + +L  ++WQ    L  ERR  ++ AL          N+  D   ++  
Sbjct: 5076 GSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYM 5135

Query: 968  KWIT-DKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
            +W+   K++V++  + + +D  G I  Q  + G+
Sbjct: 5136 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5169



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 59/292 (20%), Positives = 127/292 (43%), Gaps = 27/292 (9%)

Query: 515 ELLQSRRQRLETTLALQKLFQDMLHS------IDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
           +L+Q R+  L+++L  Q L ++ ++       ++W+DE++  L   E+G  L  VE  L+
Sbjct: 609 KLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE 668

Query: 569 KHK-----LMEADIAIQGDKVKAIT-AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEEL 622
            HK     + E + +++  K+  I   A LK T              +++  LE  + +L
Sbjct: 669 NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA------------EKLHRLESQYAKL 716

Query: 623 SNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF 682
            N +  ++  L+    L  F         W+ EKE+   + D+ +  T++   +  H   
Sbjct: 717 LNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL 773

Query: 683 EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
             EL   + +++ + + A  ++         IEA    +  QW  +  L    ++++++ 
Sbjct: 774 MRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN 833

Query: 743 ENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEE 794
             +F+F  DA +   +L++    +  +       +   L    ++ +EE EE
Sbjct: 834 TAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 885



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 68/313 (21%), Positives = 135/313 (43%), Gaps = 39/313 (12%)

Query: 293 VIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEK 352
           ++D  +  E++  K+     DLL W+++    L+  ++ + L  V+  L+    ++ V +
Sbjct: 622 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE---NHKNVHR 675

Query: 353 PPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRN 412
             +  E    E  +  IQ  M A  +  Y     +L            E++Y +   L N
Sbjct: 676 AIEEFESSLKEAKISEIQ--MTAPLKLTYAEKLHRL------------ESQYAK---LLN 718

Query: 413 ELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA--VEAAKKK--HEAIE 468
               QE+       F  +A     WL+E +    ++   YD +      A+KK  H  + 
Sbjct: 719 TSRNQERHLDTLHNFVSRATNELIWLNEKE----EEEVAYDWSERNTNIARKKDYHAELM 774

Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
            +    EE +++++++A++L  EN+  +  I A +  +   WS++ +L Q   Q ++   
Sbjct: 775 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 834

Query: 529 ALQKLFQDMLHSIDWMDEIKAHL---LSAEFGKHLLEVEDLLQ-----KHKLMEADIAIQ 580
           A  + F D   + D++  +K  +    S +    + ++EDL+Q     K +L++    I 
Sbjct: 835 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 894

Query: 581 GDKVKAITAATLK 593
               KA T   LK
Sbjct: 895 NLMGKAKTIIQLK 907



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 48/248 (19%), Positives = 103/248 (41%), Gaps = 11/248 (4%)

Query: 1599 WIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL-ASRAQGLLSAGHPE 1657
            W+ E ++ +   E   D       L+ H    RA+E++  ++K+   S  Q         
Sbjct: 643  WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTY 702

Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
             E++ RL+ Q    YA L + +  ++R L+ +++   + R T++L  W++EKE    + +
Sbjct: 703  AEKLHRLESQ----YAKLLNTSRNQERHLDTLHNF--VSRATNEL-IWLNEKEEEEVAYD 755

Query: 1718 MGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNE 1777
              +   ++   +D   +  RE     +E + +V    E+L+   H    TI  ++  +  
Sbjct: 756  WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 814

Query: 1778 MWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRV 1837
             W+ +L+L     Q +  +     +F    E    +      +      D S+  S H++
Sbjct: 815  QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS--SIHKL 872

Query: 1838 HTAFEREL 1845
                +  +
Sbjct: 873  EDLVQESM 880



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 147/816 (18%), Positives = 311/816 (38%), Gaps = 106/816 (12%)

Query: 1249 VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNL 1308
            +Q +E   RK  E   E S  L   L  Q  L +  E+      K+   Q  +   +  +
Sbjct: 1335 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATV 1391

Query: 1309 HNKWLKHQAFVAELASHEG-------WLENIDAEGKQLMDEKPQFTALVSQKLE------ 1355
             +  L+   + A + S +           + D   ++ MD + ++TALV+   +      
Sbjct: 1392 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1451

Query: 1356 -ALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLR-SDDPGKDLTS 1413
             +L RL +E ++  +EK +H+  A+          +L KW+S +   L+ ++  GK   S
Sbjct: 1452 DSLKRLEEEEKSLEEEKKEHVEKAK----------ELQKWVSNISKTLKDAEKAGKPPFS 1501

Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
                  K K   ++++ +KE+L E    +     + GD     E+  L+      +    
Sbjct: 1502 ------KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1555

Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH--- 1530
            L  S +  Q+        + VEE++   +  +Y   LQ +   + +    +N ++GH   
Sbjct: 1556 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQT---ENRLIGHQEA 1612

Query: 1531 ------TPRVEDVLQRGQQLVEAAEIDCQDLEERL----GHLQSSWDRL-REAAAGRLQR 1579
                  T  ++    + ++L +  +   Q L E +      L+ + ++L +E  A   Q+
Sbjct: 1613 FMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQK 1672

Query: 1580 LRDAN-EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR 1638
            L +A  + +Q  L A++++  + +     I +E  K    A+  L+    +   + D+  
Sbjct: 1673 LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK--VAAVKQLEESKTKIENLLDWLS 1730

Query: 1639 NIKQLASRA---------QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
            N+ + + RA         Q        +G+  I  + +V+ +     DV  +     EN+
Sbjct: 1731 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-TDVDGQVGTTQENL 1789

Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
               +Q  +     E+ IS+ + V  + +  Q      LL  + +  + E     Q+ +  
Sbjct: 1790 NQQYQKVKAQH--EKIISQHQAVIIATQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKE 1842

Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
            +    E  +     +       ++ L +  AD  E       L  +  +L        +I
Sbjct: 1843 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF---EHWLQQSEQELENLEAGADDI 1899

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869
             GL+ +  R+            +SF     + + +L  + +   +  + A        G+
Sbjct: 1900 NGLMTKLKRQ------------KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947

Query: 1870 -----KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR-DLLSWMESII 1923
                     +Q K    +  +++L   C      L D  DK++ +  A   LL+ +++  
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007

Query: 1924 R----------QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
                        ++ +   R +   + L          +E   K     L+   SLL   
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL--- 2064

Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLL 2009
              A  +I++ L  ++ R +++++    R E+L++ L
Sbjct: 2065 -PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2099



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 136/759 (17%), Positives = 292/759 (38%), Gaps = 123/759 (16%)

Query: 964  EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
            ++   W+ D+ +V     + G DL  + +       + R +   ++ +   E +  ++  
Sbjct: 638  QDLLNWV-DEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK--EAKISEIQM 694

Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
            + P  K    ++   LE  +  L  + + QE  L     L  F+    +   WL+  ++ 
Sbjct: 695  TAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEE 750

Query: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
              + D  E      +    HA +  E+D  +++ + V+E  E+++  +  P  L +    
Sbjct: 751  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL-ENHPARLTIEAYR 809

Query: 1144 EGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAA 1203
              + T W+ + ++ +     + +   + EF  DAK+A   L N +  +      D     
Sbjct: 810  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCD----R 865

Query: 1204 EAGIRKFEDFLGSMENNRDKVLS-------------------------PVDSGNKLVA-- 1236
             + I K ED +      ++++L                          P+ +   + A  
Sbjct: 866  SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAIC 925

Query: 1237 -----EGNLYSDKIKEKVQLIEDRHR-------KNNEKAQEASVLL------RDNLELQN 1278
                 E  +Y D   ++  L  + HR           +A   SV        ++ ++L N
Sbjct: 926  DYRQIEITIYKD---DECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN 982

Query: 1279 FLQNCQE--LTLW----INDKLLTSQDVSYDEARNLHNKWL---------KHQAFVAELA 1323
             ++   +  LTLW    IN K + S     +E   +    +         +HQ  ++ L 
Sbjct: 983  RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQ 1042

Query: 1324 SH-EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ-------HL 1375
            S  E +LE  D++  Q+          + +++    + + EL  + + + Q       ++
Sbjct: 1043 SRFEDFLE--DSQESQVFSGSD--ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI 1098

Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKD---LTSVNRMLAKLKRVEDQVNVRK 1432
            S  R+  LRL+   D  + I  +   L  DD  +    +T   ++  +L+R++D +    
Sbjct: 1099 SEVRNIRLRLENCED--RLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 1156

Query: 1433 EELGELFAQ------VPSMGEE------GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480
             +  E F+Q      VP++  E        +   S+   ++D L+ +    K  +++ A 
Sbjct: 1157 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1216

Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
            +++      ET   EE   +A       N++ +   +K+ ++  +E       +ED LQ+
Sbjct: 1217 VKLY-----ETKLCEEEAVIADK----NNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1267

Query: 1541 GQQL-------VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
             + +        +  ++D    +E+   L   W  +      RL+ L    ++ +YY D 
Sbjct: 1268 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1327

Query: 1594 -DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQR 1631
                + WI  Q++     +I +++      L   L QQ+
Sbjct: 1328 YHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQK 1364



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 9/224 (4%)

Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV-----EDQVNVRKEELG 1436
            ++ ++   DL  W+  M+ QL   + G DL SV   L   K V     E + ++++ ++ 
Sbjct: 631  EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 690

Query: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEE 1496
            E+    P +     +    +E ++  LL     +++ L++      +SR   +E +W+ E
Sbjct: 691  EIQMTAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN--FVSR-ATNELIWLNE 746

Query: 1497 RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLE 1556
            +     + D+      +      +  L  E+      ++ V +  +QL+         +E
Sbjct: 747  KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 806

Query: 1557 ERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
                 +Q+ W  + +      Q +++     +++ DA EA  ++
Sbjct: 807  AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 850



 Score = 33.9 bits (76), Expect = 1.8
 Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 32/212 (15%)

Query: 1808 EILGLIDEKHRELPE-----DVGLDASTAESFHRVHTAFER-ELHLLGVQVQQFQDVATR 1861
            ++L  +DE   +L       D+    S  E+   VH A E  E  L   ++ + Q  A  
Sbjct: 639  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP- 697

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L+  YA         K   + + +  LL+    +   L DT   F   S A + L W+  
Sbjct: 698  LKLTYA--------EKLHRLESQYAKLLNTSRNQERHL-DTLHNF--VSRATNELIWLNE 746

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
               +    +     +++     YH  +  E++ + +N  +  E+ E LL   H A   I 
Sbjct: 747  KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 806

Query: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
                   + R  M  +W   W     +L++CQ
Sbjct: 807  -------AYRAAMQTQWS--W-----ILQLCQ 824



 Score = 32.0 bits (71), Expect = 6.7
 Identities = 47/286 (16%), Positives = 105/286 (36%), Gaps = 20/286 (6%)

Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
            DL  W+ E ++     E G D   V    +  ++  R            +  F   L +A
Sbjct: 639  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA-----------IEEFESSLKEA 687

Query: 1761 GHSEAATIAEWK----DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGA-EILGLIDE 1815
              SE    A  K    + L+ + +   +L++T          LH +      E++ L ++
Sbjct: 688  KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 747

Query: 1816 KHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQ 1875
            +  E+  D     +        H    REL      ++  Q++A +L       +   I+
Sbjct: 748  EEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL-TIE 806

Query: 1876 NKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQ---ERP 1932
                 +   W  +L  C      + +    F FF+ A++   ++ ++   I+ +   +R 
Sbjct: 807  AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS 866

Query: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASE 1978
              +  +E L++       E+       +  +   ++++Q + + S+
Sbjct: 867  SSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 912


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  298 bits (763), Expect = 4e-80
 Identities = 172/388 (44%), Positives = 234/388 (60%), Gaps = 15/388 (3%)

Query: 48  LADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGK 107
           +ADER+ VQKKTFTKW+N HL +V   + DLY+DLRDG  LI LLEVLSG+ LP+  KG+
Sbjct: 69  IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 127

Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ 167
           MR H L+NV  AL +LK ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  +
Sbjct: 128 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 187

Query: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKD 227
              E  SAK+ LLLW Q  T GY  +   NFT+ W+DG  FNA+IHK+RPDLID + +  
Sbjct: 188 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245

Query: 228 SNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEG 287
            +   NLEHAF VAE+ +G+I LLDPEDV   +PDEKS+ITYV + Y  F K   +   G
Sbjct: 246 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK---VPEGG 301

Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTY 347
           + +G     A + E    +Y  + + L+ WI   +T ++ R F N+   ++     +  +
Sbjct: 302 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 356

Query: 348 RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRE 407
           +  E PPK  EK  ++ L   ++  +     K+     G   +DI + W  L  A   RE
Sbjct: 357 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 413

Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRE 435
            ALR E+ R E L+Q+A R  R + + E
Sbjct: 414 KALRPEVERLEMLQQIANRVQRDSVICE 441



 Score =  171 bits (432), Expect = 9e-42
 Identities = 321/1659 (19%), Positives = 676/1659 (40%), Gaps = 141/1659 (8%)

Query: 387  KLVSDINRAWESL-EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRL 444
            K +S ++  WE+L  +AE R          + E +  +A++F         WL+   +RL
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNR--------QLEGISVVAQQFHETLEPLNEWLTTIEKRL 3478

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
            V  +  G   + +E    +H+A+E D   + + +     + Q L+  +  + K +   K 
Sbjct: 3479 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3538

Query: 505  NILRLWSY-LQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEIKAHLLSAEFGKHLLE 562
            +  ++W   +QE   SR + L+  L   K+F +D +  ++W++E+   L       +  E
Sbjct: 3539 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598

Query: 563  VEDLLQKH-KLMEADIAIQGDKVKAITA---ATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
                 Q   ++++ DI ++   V          LK T G      +  +IQD++  ++  
Sbjct: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGD-----EVLIIQDKLEAIKAR 3653

Query: 619  FEELSNMAAGRKAQLEQSKRLWKFFWEM-DEAESWIKEKEQIYSSLDY----GKDLTSVL 673
            +++++ ++      LEQ+ +L +      +E  +W+ + E    S +     G++ +   
Sbjct: 3654 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA- 3712

Query: 674  ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQLKDLA 732
              Q + K  + E +   A L+ + + +  ++    +     +E  + E + ++  + D  
Sbjct: 3713 --QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3770

Query: 733  AFCKKNLQDAE-NFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKHKDFLE 790
                + +  A     QF   AD   +W+ +  + L+S  D+  ++  T A  +  K F  
Sbjct: 3771 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3830

Query: 791  ELEESRGVMEHLEQQAQGF----PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
            E+   + +++ L +          EE + S  +  +L  + + Y  +      R  +L+ 
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLER 3888

Query: 847  ALDLYTVFGET-DACELWMGEKEKWLAEMEMPDT-LEDLEVVQHRFDILDQEMKTLMTQI 904
            A  L   F ET +    W+ E +  ++++  P    E L   Q     L + +      I
Sbjct: 3889 AQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3948

Query: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
            D +N     L+E        +++     +T +   +  V +R  A+D A+       D  
Sbjct: 3949 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD-- 4006

Query: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLS---GLERDVAAIQARVDALERESQQL 1021
            +  + +    ++VE  +      A +  I+ ++S    +  D+  +Q   + L++  +++
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 1022 MDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-QAFLQDLDDFQA 1075
            +       +DI  +  Q  L+++   W+ +   ++ +E  L +V +L + F  D      
Sbjct: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126

Query: 1076 WLSITQKAVASEDMPESLPEAEQLLQQHAG-IKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134
             +  TQ  +   + P   P   +  Q+ A  I++EIDG Q+    V   G ++I    +P
Sbjct: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4186

Query: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAE-AILSNQEYTLAH 1193
            +  ++ + ++ L++ W++L + W+ R   L + +      +D  QA    +      LA 
Sbjct: 4187 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLAS 4246

Query: 1194 LEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-------- 1244
            + P    LE  +  I + + F       + ++         L+ +    SDK        
Sbjct: 4247 MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLM 4306

Query: 1245 -IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI--NDKLLTSQDVS 1301
             +K     +E+R      K + A       L L  F     EL  W+   + LL+ Q   
Sbjct: 4307 ELKLIWDSLEERIINRQHKLEGAL------LALGQFQHALDELLAWLTHTEGLLSEQKPV 4360

Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP-QFTALVSQKLEALHRL 1360
              + + +  +  KH     ++ +H+  +E ++  G  L++    +  + +  KLE L++ 
Sbjct: 4361 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4420

Query: 1361 WDELQATTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDP-------GKDLT 1412
            W  +   T+++ Q L  A R +        DL +W++  E  L +  P        K+  
Sbjct: 4421 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4480

Query: 1413 SVN-RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL-SIEKRFLDLLEPLGRR 1470
            +V+  + A  +  E+      ++  ++ A+ P   E   D D+ ++++++  +   L  R
Sbjct: 4481 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4540

Query: 1471 KKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
            K +LE +    ++    L+D   W+   E+ L +A        L TV   + +++   NE
Sbjct: 4541 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP--SLILDTVLFQIDEHKVFANE 4598

Query: 1527 ILGHTPRVEDVLQRGQQL-VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE 1585
            +  H  ++ ++ + G  L   + + D   ++  L  +QS W+++ +    R + L DA +
Sbjct: 4599 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4658

Query: 1586 -AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQRAV---------- 1633
             A+Q++    +   W+ E E  + S+ EI  D +     L +H   Q+++          
Sbjct: 4659 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4718

Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693
               GR++K+  S A   L       + +  L+ + D     +   + ER+ KLE    L 
Sbjct: 4719 NRTGRSLKEKTSLADDNLKL----DDMLSELRDKWDT----ICGKSVERQNKLEEA--LL 4768

Query: 1694 QLKRETDDLEQWIS-----EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVD 1748
               + TD L+  I      E +L    P  G D D V  L D  + F +E G    +R  
Sbjct: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELG----KRTS 4823

Query: 1749 NVNAF---IERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY----DLHR 1801
            +V A       LI+    +++ +      L+  W  +  L  ++   L A+     + H 
Sbjct: 4824 SVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHS 4883

Query: 1802 YFYTGAEILGLIDEK---HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
              +   E L   ++    H  LP+    D     +    H  F ++L     ++ +   +
Sbjct: 4884 VVHALLEWLAEAEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4939

Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA-----DKFRFFSMAR 1913
               +      +    I++    + A ++ +L A A +  Q + +A      K        
Sbjct: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVL-AWAKQHQQRLASALAGLIAKQELLEALL 4998

Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
              L W E+ +   + +  P+++  V+ L+  HQ    E+
Sbjct: 4999 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037



 Score =  157 bits (397), Expect = 1e-37
 Identities = 322/1813 (17%), Positives = 717/1813 (39%), Gaps = 209/1813 (11%)

Query: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
            ++ I   W++  +    RE  L+  L       + A ++  +      W+ + Q  + + 
Sbjct: 2883 LNTIKTNWDTFNKQVKERENKLKESL-------EKALKYKEQVETLWPWIDKCQNNLEEI 2935

Query: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
             F  D A  E +  K ++++ +   +   V  L + A  L      D++ +T    ++++
Sbjct: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2995

Query: 509  LWSYLQELLQSRRQRLETTLALQKLFQDML-----------HSIDWMDEIKAHLLSAEFG 557
                + E L S++  LE      K FQ++              +D  D + +   S ++ 
Sbjct: 2996 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3055

Query: 558  KHLLEVEDLLQ--KH-----KLMEADIAIQGDKVKAITAATLKF-TEGKGYQPCDPQV-- 607
              L   +  LQ  KH     K +  D+ ++    K  +   L+  T  + +     QV  
Sbjct: 3056 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3115

Query: 608  ------------------IQDRISHLEQCFEELSNMA-AGRKAQLEQSKRLWKFFWEMDE 648
                              I++  S   +  +EL +MA  GR A+  Q ++        + 
Sbjct: 3116 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQK--------ET 3167

Query: 649  AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
             ++++K+ E + +S D       +++   +      +L G+   LE + ++ + ++ R Q
Sbjct: 3168 IKAFLKKLEALMASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDRAQ 3224

Query: 709  FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
                Q+E  IK +   + +LK+ +      LQ AE   + QG               +  
Sbjct: 3225 AREEQVEGTIKRLEEFYSKLKEFSIL----LQKAEEHEESQGPVG------------MET 3268

Query: 769  EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD---VTHRLQA 825
            E + Q     +   K      EE+E  +G  + +    QG  +    S     + H L  
Sbjct: 3269 ETINQQLNMFKVFQK------EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3322

Query: 826  LRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLE 884
            +   ++ +  +   R  +LQEAL     F +  ++   WM + E+ +A  + P    + +
Sbjct: 3323 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA--EFK 3380

Query: 885  VVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EVKQYQDHLNTRWQAFQ 940
            VV+ +     +L + +    + ++ +      +  +  P  + ++ +    L++RW+A  
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3440

Query: 941  TLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
                 R   ++  ++    +    E  ++W+T   K + + + +G   + +     +   
Sbjct: 3441 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKA 3500

Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ-GLQQSLQGQEDLLG 1058
            LE D+      +       Q L      + +D+ Q +    ++W   +Q+    + +LL 
Sbjct: 3501 LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQ 3560

Query: 1059 E-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI-KDEIDGHQDS 1116
            + +   + F +D  +   WL+     ++   + +   E     Q    + +++I   + +
Sbjct: 3561 QALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQN 3620

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ---------- 1166
              +   +G ++++  T  E L++  +LE +   +  + ++    + TL Q          
Sbjct: 3621 VDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHS 3680

Query: 1167 -----CLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
                 C    + + +    E  +L  +E + A + P +  + A    +  +  L S+   
Sbjct: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA----KNNKALLDSLNEV 3736

Query: 1221 RDKVLSPV-----DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
               +L  V     +   K+VAE N    L SD I +KV+ I+             + +LR
Sbjct: 3737 SSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-------------AAILR 3783

Query: 1272 DNLELQNFLQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
                 Q F Q       WI +   KL++  D+  ++ +      ++ + F  E+  H+  
Sbjct: 3784 S----QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQ-KTFTMEILRHKDI 3838

Query: 1329 LENIDAEGKQLM----DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
            ++++   G ++M    +E+ Q    + +KL+ + + +D +     E+   L  A+S   +
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQ---SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3895

Query: 1385 L-QTHADLNKWISAMEDQL-RSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV 1442
              +T+ +L  W++  +  + +   P  +  ++ +   + +++ + +   K  + ++    
Sbjct: 3896 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3955

Query: 1443 PSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
            P + E       SI+++++        + E + +R   L+ + ++     D  D+ L   
Sbjct: 3956 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4015

Query: 1496 ERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA----- 1548
            ER+   L Q       ++ ++  + +N+ +  ++    P  E + QRG++++  +     
Sbjct: 4016 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4075

Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYV 1607
            +I  + ++++L  +   W+ +      R  +L D  E A++++ D       I + + ++
Sbjct: 4076 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4135

Query: 1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR--------AQGLLSAGHPEGE 1659
               E P  +   +       +QQ A E     I  L           ++ + + G P+  
Sbjct: 4136 RDLEDPGIDPSVV------KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4189

Query: 1660 QIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQW--ISEKELVASSP 1716
             + +   +++  +  L    ++R  KLE  M    Q +     +  W  I+  +L + SP
Sbjct: 4190 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4249

Query: 1717 EMGQDFDHVTLLRDKFRDFARET--GAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDG 1774
             +G D + V    ++ + F  E     I  ER+++    + + +    S+  T+ +    
Sbjct: 4250 -IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV-TEESDKHTVQDPLME 4307

Query: 1775 LNEMWADLLE-LIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPED--VGLDASTA 1831
            L  +W  L E +I+ + +L  A   L ++ +   E+L  +      L E   VG D    
Sbjct: 4308 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367

Query: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
            E     H   + ++      V+        L  + AGE+A  +QNK + ++  WQ +L+ 
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427

Query: 1892 CAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYHQGIN 1949
               R+ QL     + + F     DL  W+    R +   +    +  + +  +  H  + 
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4487

Query: 1950 AEIETRSKNFSACLELGESLLQRQHQASE--------EIREKLQQVMSRRKEMNEKWEAR 2001
            A  E + + + + ++ G+ +L R  +++E         ++EK + V ++  E   K E  
Sbjct: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE-- 4545

Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYL-ASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
             E L + +E   F         WL   E  L  +      +D+V   I  H+ F     S
Sbjct: 4546 -EALNLAME---FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601

Query: 2061 WAERFAALEKPTT 2073
              E+   L+K  T
Sbjct: 4602 HREQIIELDKTGT 4614



 Score =  155 bits (393), Expect = 3e-37
 Identities = 308/1553 (19%), Positives = 632/1553 (40%), Gaps = 124/1553 (7%)

Query: 606  QVIQDRISHLEQCFEELSNMAAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLD 664
            Q ++  +  +   ++ L+   A R AQL+++     +F   ++   SW+ + E++ ++  
Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373

Query: 665  YGKDLTSVLILQ-RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHP-QIEARIKEVS 722
                   V+  Q ++ K  +  L    + +E I +E   +    +     +I  ++  + 
Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433

Query: 723  AQWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAH-RLLSGEDVGQDEGATRA 780
            ++W+ L + A    + L+      Q F    + L  WL     RL++ E +G        
Sbjct: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493

Query: 781  LGKKHKDFLEELEESRGVMEHLEQ-----QAQGFPEEFRDSPDVTHRLQALRELYQQVVA 835
               +HK   +++       +HL Q     Q+        D   V  +L   +  Y ++  
Sbjct: 3494 QIAQHKALEDDIINHN---KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550

Query: 836  QADLRQQRLQEALDLYTVFGETDACEL--WMGEKEKWLAEMEMPD-TLEDLEVVQHRFDI 892
            ++  R + LQ+AL    +FGE D  EL  W+ E    L+++ + D + E L   Q    +
Sbjct: 3551 KSHSRSELLQQALCNAKIFGE-DEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3609

Query: 893  LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNT---RWQAFQTLVSERREA 949
            L +++      +D   L    L++       EV   QD L     R++    L ++  + 
Sbjct: 3610 LQEDILLRKQNVDQALLNGLELLKQ--TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667

Query: 950  VDSAL----RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKL--SGLERD 1003
            ++ AL    R+H+     EE   W+ DK +V E      + L G  A Q ++    L+++
Sbjct: 3668 LEQALQLARRLHS---THEELCTWL-DKVEV-ELLSYETQVLKGEEASQAQMRPKELKKE 3722

Query: 1004 VAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQSL-QGQEDLLGEVS 1061
                +A +D+L   S  L++  P   +E + +      E ++ +  ++ Q  E++   + 
Sbjct: 3723 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782

Query: 1062 QLQAFLQDLDDFQAWLSITQKAVAS-EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRV 1120
            + Q F Q  D   +W++ T+K + S  D+     +    LQ       EI  H+D    +
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842

Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGF-QEFQKDAKQ 1179
             +SG K++   ++ E   + ++L+ +   ++ + ++   R   L +      +F +  ++
Sbjct: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902

Query: 1180 AEAILSNQEYTLAHLEPP----DSLEAAEAGIRKFEDFLGSMENNRDKV---------LS 1226
                L+  +  ++ L  P    ++L   +   R+  + +   + + DK+         LS
Sbjct: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962

Query: 1227 PVDSGN---KLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNC 1283
            P +  +   K VA   LYS +IKE V+          ++A      +  + +  + +   
Sbjct: 3963 PGEGFSIQEKYVAADTLYS-QIKEDVK----------KRAVALDEAISQSTQFHDKIDQI 4011

Query: 1284 QELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM--- 1340
             E    I ++L     +S  E   +  +  +++    ++   +   E +   G++++   
Sbjct: 4012 LESLERIVERLRQPPSISA-EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4070

Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEK-TQHLSAARSSDLRLQTHADLNKWISA 1397
               +K      V  KL+ +  +W+ +    +E+  + L     ++     H  L   I  
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4130

Query: 1398 MEDQLRS-DDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSI 1456
             +D +R  +DPG D + V +     + + ++++  +EEL  +      +    G+ D  I
Sbjct: 4131 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4190

Query: 1457 EKRFLDLLEPL---------GRRKKQLESSRAKLQISRDLEDETLWVE-ERLPLAQSADY 1506
             K+ +D L             R  K  E+ +A +Q    L+    WV+     LA  +  
Sbjct: 4191 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250

Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQS 1564
            GT+L+TV+  +++ +  ++E       +E +  + + L++    E D   +++ L  L+ 
Sbjct: 4251 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310

Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAEAWIGEQELYVISDEIPK--DEEGAIV 1621
             WD L E    R  +L  A  A   +  A DE  AW+   E  ++S++ P   D +   +
Sbjct: 4311 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE-GLLSEQKPVGGDPKAIEI 4369

Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDV 1678
             L +H   Q  V  +   ++ +      L+ +    GE+   LQ +++   + +  + + 
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS--AGEEASNLQNKLEVLNQRWQNVLEK 4427

Query: 1679 AEERKRKLENMYHLFQ-LKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDF 1735
             E+RK++L+      +    E +DL+QW++  E+ L+AS P  G        L     + 
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL-----NV 4482

Query: 1736 ARETGAIGQERVDNVNAFIER----LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
              E  A  + + +   + +++    L     S    I +  + L E W  +   ++ R  
Sbjct: 4483 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4542

Query: 1792 LLAASYDLHRYFYTGAE-ILGLIDEKHREL--PEDVGLDASTAESFHRVHTAFERELHLL 1848
             L  + +L   F+   +  +  + +  + L       L   T       H  F  E++  
Sbjct: 4543 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4602

Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
              Q+ +     T L+     +    I+N    V + W+ ++     R   L D   + + 
Sbjct: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662

Query: 1909 FSMA-RDLLSWMESIIRQIETQ-ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELG 1966
            F  A   L+ W+E   + ++++ E   D   ++  +  H+     +  +   +      G
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722

Query: 1967 ESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAE 2022
             SL ++   A + +  KL  ++S   E+ +KW+       ER   L E   FS   + A 
Sbjct: 4723 RSLKEKTSLADDNL--KLDDMLS---ELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777

Query: 2023 A----WLIAQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
                 WL   EP LA     H  +D V  LI  H+AF+K          AL++
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830



 Score =  149 bits (375), Expect = 4e-35
 Identities = 358/1838 (19%), Positives = 731/1838 (39%), Gaps = 212/1838 (11%)

Query: 359  KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE 418
            K   EVLL    S + A N    T  D  +V       +S+ E   + ++ L   L  Q+
Sbjct: 2061 KKTAEVLLDARGSLLPAKNDIQKTLDD--IVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118

Query: 419  KLEQLARRFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEER 477
             L+++             W+      L  Q     +  A++    K+  +E D A  +  
Sbjct: 2119 GLDEML-----------DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2167

Query: 478  VRALEDLAQE-LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
            + A+ +  ++ +E  +      + A+  ++   +S      +    ++E      +LF++
Sbjct: 2168 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2227

Query: 537  MLHSIDWMDEIKAHLLSAEF--GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
            +   +    E K   L+     GK + E+   +Q+         ++  K   +  + LK 
Sbjct: 2228 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQE----STSEFLEHKKHLEVLHSLLKE 2283

Query: 595  TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKFFWEMDEAESWI 653
                G  P D  ++ ++ ++L + F+E+ +    +K  +    ++L  F   +   +SWI
Sbjct: 2284 ISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWI 2342

Query: 654  KEK-------EQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------LEQIFQE 699
            KE        +  + + D GK L     LQ K      E++ ++         +  +   
Sbjct: 2343 KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP 2402

Query: 700  AHGMVARKQFGH--------------------PQIEARIKEVSAQWDQL----KDLAAFC 735
            A  + A K  G                       I+  + ++S  ++ L    KD  A  
Sbjct: 2403 AKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAEL 2462

Query: 736  KKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEGATRALGKKHKDFLEEL 792
               L   +   + Q ++  +  WLQ  ++  +         D  A +   +++K F  EL
Sbjct: 2463 NTKLSKLQ---KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2519

Query: 793  EESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALD 849
            +++   ++ L+ +     EE  D+P+     Q L E+   +Q++      RQQ+L+E+ +
Sbjct: 2520 KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSN 2579

Query: 850  LYTVFGETDA-CELWMGEKEKWLAEMEMPDTLED--LEVVQHRFDILDQEMKTLMTQIDG 906
              T F   +A  + W+ EKE  ++ +  P +++   L   + +  IL QE  T   Q + 
Sbjct: 2580 NLTQFQTVEAQLKQWLVEKELMVSVLG-PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638

Query: 907  VNLAANSLVES-GHPRSRE--VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDC 963
            +  A   ++   G   S    VK+    +  +W +    +S+R + +D A+         
Sbjct: 2639 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAI--------- 2689

Query: 964  EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
             +++++ +    + +   DL   L+  +A+      + + +   Q     +++E +Q+  
Sbjct: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749

Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQG--------QEDLLGEVSQLQA-------FLQ 1068
            +     ED+    K  E L   L + L+G        ++     V  LQ+       F Q
Sbjct: 2750 AQA-LCEDLSALVKE-EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807

Query: 1069 DLDDFQAWLSITQKAVASEDMPES--LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEK 1126
               DFQAWL  T+K   ++  P S  L   E L++ H      +      Y++    GE 
Sbjct: 2808 MSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN 2866

Query: 1127 VIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI--- 1183
            ++      E   L  +L  + T W+   +  + R + L + L  ++  K  +Q E +   
Sbjct: 2867 LLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL--EKALKYKEQVETLWPW 2924

Query: 1184 -------LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NNRDKVLSPVDSGNK 1233
                   L   ++ L   E  +S+   ++  ++ +   G +E   N  + +LS  +   +
Sbjct: 2925 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 2984

Query: 1234 LVAEGNLYSDKIKEKVQLI-EDRHRKN---NEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
            +V + N     + +KV ++ E  H K        Q+       + E +  LQ C +  L 
Sbjct: 2985 VVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ-CAKEQLD 3040

Query: 1290 INDKL----LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ 1345
            I+D L     +++ ++  + +    + LKHQ  +A+  + +  +E  D++G         
Sbjct: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--------- 3091

Query: 1346 FTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS 1404
             T+ V  ++E + +    L     EK   L          Q T  ++    +  +D+L S
Sbjct: 3092 -TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDS 3150

Query: 1405 DDP-GKDLTSVNR----MLAKLKRVE----DQVNVRKEELGELFAQVPSMGEEGGDADL- 1454
              P G+D  ++ +    + A LK++E       N  K     L  +  S    G   DL 
Sbjct: 3151 MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLE 3210

Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKLQ--ISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
            ++ K+   LL+    R++Q+E +  +L+   S+  E   L  +           G   +T
Sbjct: 3211 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3270

Query: 1513 VQLFMKKNQTLQ-NEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRL 1569
            +   +   +  Q  EI     + +DV   GQ L+++A      Q LE  L  + + W  L
Sbjct: 3271 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3330

Query: 1570 REAAAGRLQRLRDANEAQQYYLDADEA-EAWIGEQELYVISDEIPKDEEGAI-VMLKRHL 1627
             +  A R  +L++A      + DA E+  +W+ + E  V + + P  E   +   ++   
Sbjct: 3331 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3390

Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGE-QIIRLQGQVDKHYAGLKDVAEERKRKL 1686
              QR ++D    ++ +    + + +   P  + +I++    +D  +  L + AE R R+L
Sbjct: 3391 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3450

Query: 1687 ENMYHLFQLKRET-DDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
            E +  + Q   ET + L +W++  EK LV   P        +     K  +   +  A+ 
Sbjct: 3451 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP--------IGTQASKLEEQIAQHKAL- 3501

Query: 1744 QERVDNVNAFIERLIDAGHS-------EAATIAEWKDGLNEMW-ADLLELIDTRMQLLAA 1795
            ++ + N N  + + +  G S       E   + + K   +++W  ++ E   +R +LL  
Sbjct: 3502 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3561

Query: 1796 SYDLHRYF-YTGAEILGLIDEKHRELPEDVGLDASTAESFHRVH--TAFERELHLLGVQV 1852
            +    + F     E++  ++E H +L +    D ST   + +       + ++ L    V
Sbjct: 3562 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3621

Query: 1853 QQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-----R 1907
             Q       L     G++   IQ+K + + A ++ +        T +  T ++      R
Sbjct: 3622 DQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL----STDVAKTLEQALQLARR 3677

Query: 1908 FFSMARDLLSWMESI---IRQIETQE-RPRDVSSVELLMKYHQGINAEIETRSKNFSACL 1963
              S   +L +W++ +   +   ETQ  +  + S  ++  K       E++  +KN  A L
Sbjct: 3678 LHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-------ELKKEAKNNKALL 3730

Query: 1964 ----ELGESLLQR-QHQASEEIREKLQQVMSRRKEMNEKWEARWERL-RMLLEVCQFSRD 2017
                E+  +LL+    +A E + + + +   R + +++    + E +   +L   QF + 
Sbjct: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790

Query: 2018 ASVAEAWLIAQEPYLAS-GDFGHTVDSVEKLIKRHEAF 2054
            A    +W+   E  L S GD     D     ++  + F
Sbjct: 3791 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3828



 Score =  129 bits (325), Expect = 2e-29
 Identities = 389/2030 (19%), Positives = 780/2030 (38%), Gaps = 278/2030 (13%)

Query: 277  FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSG--LASDLLTWIEQTITVLNSRK---FA 331
            FSK K+ + E     + +  A++T ++     G  +  +    +E+ +  L       F+
Sbjct: 1511 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1570

Query: 332  NSLTGVQQQLQAFSTYRTV--------EKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTP 383
             SL    +QLQ   T   V        E+  +++EK      L T        +Q+ +  
Sbjct: 1571 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1626

Query: 384  HDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
             DG +              E ++  + + EL  Q+ ++  A+         E +L EN  
Sbjct: 1627 GDGTV--------------ELKKYQSKQEEL--QKDMQGSAQALAEVVKNTENFLKENGE 1670

Query: 444  LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
             ++Q++       +  AK K E +       ++ +  +   A + E E     K++   K
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1730

Query: 504  DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH--------SIDWMDEIKAHLLSAE 555
              I  L  +L  +   +      T   Q + Q+  H        +I   DE+  +LL  +
Sbjct: 1731 TKIENLLDWLSNV--DKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788

Query: 556  FGKHLLEVEDLL----QKHKLMEADIAIQGDKVKAIT--AATLKFTEGKGYQPCDPQVIQ 609
                +   ++ L    QK K     I  Q   V   T  A  L   +G+   P + + +Q
Sbjct: 1789 VDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ 1848

Query: 610  DRISHLEQCFEE-LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYG-K 667
              +  L+  +E  L+      K      + L KF  +  E E W+++ EQ   +L+ G  
Sbjct: 1849 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908

Query: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQI------FQEAHGMVARKQFGHPQIEARIKEV 721
            D+  ++   ++ K+F +++      L  I        EA    +++  G     A  +EV
Sbjct: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1968

Query: 722  SAQWDQLKD----LAAFCK---KNLQDAENFFQFQGDAD-DLKAWLQDAHRLLS---GED 770
              + D   D    L + C     NL+D  + +Q   DA   L A LQ      S    E 
Sbjct: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2028

Query: 771  VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE----FRDSPDVTHRLQAL 826
            +  D    +   ++ K    ++   +  +E L++ A+   +          D+   L  +
Sbjct: 2029 IAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI 2088

Query: 827  RELYQQVVAQADLRQQRLQEALD-LYTVFGETDACELWMGEKEKWLAEM-EMPDTLEDLE 884
               Y+ +    + R ++LQ  L    +V    D    WMG  E  L E  ++P     L+
Sbjct: 2089 VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ 2148

Query: 885  VVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP----------------------RS 922
             +  +  +L+Q++    + I+ +N      +E+  P                      + 
Sbjct: 2149 DIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKH 2208

Query: 923  REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV-ESTK 981
            +E     + L T+ + F+ L  + +  +++  +      + +   K +T+ ++ + EST 
Sbjct: 2209 KETLAKMEELKTKVELFENLSEKLQTFLETKTQA---LTEVDVPGKDVTELSQYMQESTS 2265

Query: 982  DL---GRDLAGIIAIQRKLS--GLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ 1036
            +     + L  + ++ +++S  GL  D A +  + + L ++ +++ D+  E+KE +   Q
Sbjct: 2266 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQ 2325

Query: 1037 KHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
            + L + +Q L +SL+                  + +    + I Q +  +ED+ +SL + 
Sbjct: 2326 EQL-DAFQVLVKSLKSW----------------IKETTKKVPIVQPSFGAEDLGKSLEDT 2368

Query: 1097 EQLLQQHAGIKDEIDGHQDS----------------YQRVKESGEKVIQGQ---TDPEYL 1137
            ++L ++ +    EI    +S                     +SG  V+ G+   T+ E  
Sbjct: 2369 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2428

Query: 1138 LLGQRLEG-------LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS----- 1185
               + L         +  G+  LG + + +   L   L   + QK  +++ A++      
Sbjct: 2429 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL--SKLQKAQEESSAMMQWLQKM 2486

Query: 1186 NQEYTLAHLEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEG--NLYS 1242
            N+  T     P P   EA +  + + + F   ++ N +KV    D   +L+ E      +
Sbjct: 2487 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2546

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQ--- 1298
             + K+ +  I+ + ++ N+   +    L ++   L  F     +L  W+ +K L      
Sbjct: 2547 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2606

Query: 1299 DVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD---EKPQFTALVSQKLE 1355
             +S D    L+ +  + Q  + E A+ +   E + A G+ ++    E P    +V ++L 
Sbjct: 2607 PLSID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665

Query: 1356 ALHRLWDELQATTKEK-----------TQHLSAARSSDLRLQTHADL-NKWISAMEDQLR 1403
            A+ + WD L     ++           TQ+ S  RS   +L   +DL NK  S++     
Sbjct: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL---SDLDNKLSSSLAVSTH 2722

Query: 1404 SDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLS-----IEK 1458
             D   + L +  +M  ++++ + Q+ V +    +L A V    EE   A+LS     I K
Sbjct: 2723 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK---EEYLKAELSRQLEGILK 2779

Query: 1459 RFLDLLEPLGRRKKQLESSRAK----LQISRDLEDETLWVE-ERLPLAQSADYGTNLQTV 1513
             F D+ +      + L+S+ A      Q+SRD +    W++ ++    +S      L  +
Sbjct: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVL 2836

Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQ-LVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
            +  +K ++     +   +   E  +  G+  L++    +   L+ +L  ++++WD   + 
Sbjct: 2837 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2896

Query: 1573 AAGRLQRLRDANE-AQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRH 1626
               R  +L+++ E A +Y    +    WI +     +E+    D  P + E +I  LK  
Sbjct: 2897 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLK-- 2952

Query: 1627 LRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKL 1686
               Q+ ++ +   ++ L + A  LLS    + E +      + +    + +    +K  L
Sbjct: 2953 -SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3011

Query: 1687 ENMYHLFQLKRET--DDLEQWISEKELVASSPEMGQDF---DHVTLLRDKFRDFARETGA 1741
            ENM   F+  +E   +   Q    KE +     +G       ++T+L+ + +        
Sbjct: 3012 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071

Query: 1742 IGQERVDNVNAFIERLIDAGHS----EAATIAEWKDGLNEMWADLLELIDTRMQLLAASY 1797
            +   +    +  +E     G S    +  TIA+    L++   +    ++T++Q +    
Sbjct: 3072 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3131

Query: 1798 DLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELH-LLGVQVQQFQ 1856
            +  R  +  ++     DE     P  VG DA T +       AF ++L  L+       +
Sbjct: 3132 NTIREMF--SQFAEFDDELDSMAP--VGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3187

Query: 1857 DVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMARDL 1915
                 L T         I+   + +S     LLD    R  Q+  T  +   F+S  ++ 
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3247

Query: 1916 LSWMESIIRQIETQ----ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
               ++      E+Q         ++    + K  Q    EIE           LG+ L+Q
Sbjct: 3248 SILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQ 3305

Query: 1972 --RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQE 2029
               +  +++ +   L  V +R K +N+K   R  +L+  L  C                 
Sbjct: 3306 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC----------------- 3348

Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASW---AERFAALEKPTTLELK-------ER 2079
                    G   D++E L+           SW    E   A +KP + E K       E+
Sbjct: 3349 --------GRFQDALESLL-----------SWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389

Query: 2080 QIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESL 2129
            ++ +R  ++     E  +  GE   +     ++   +   S L S WE+L
Sbjct: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3439



 Score =  102 bits (254), Expect = 4e-21
 Identities = 315/1749 (18%), Positives = 686/1749 (39%), Gaps = 177/1749 (10%)

Query: 387  KLVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRFDRKAAMRETWLSENQRLV 445
            K ++DI+  +E L        L L++++     KL +L +  +  +AM + WL +  +  
Sbjct: 2439 KDMTDISHGYEDLG-------LLLKDKIAELNTKLSKLQKAQEESSAMMQ-WLQKMNKTA 2490

Query: 446  A---QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN--YHDQKRIT 500
                Q     D  AV+   +++++ E +      +V+ L+D   EL +EN    +  R  
Sbjct: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2550

Query: 501  ARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFGKH 559
                 I   W  L +L   R+Q+LE +      FQ +   +  W+  ++  L+ +  G  
Sbjct: 2551 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPL 2608

Query: 560  LLEVEDL---LQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
             ++   L    Q+ +++  + A +  + + +TAA        G  P    +++++++ + 
Sbjct: 2609 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2668

Query: 617  QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
            Q ++ L+   + R   ++Q+        +  + +S ++      S LD    L+S L + 
Sbjct: 2669 QKWDSLTGQLSDRCDWIDQA------IVKSTQYQSLLRSLSDKLSDLD--NKLSSSLAVS 2720

Query: 677  RKHKAFEDELRGLDAHLEQIFQEAH------------GMVARKQFGHPQIEARIKEVSAQ 724
                A   +L       ++I QE                + ++++   ++  +++ +   
Sbjct: 2721 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2780

Query: 725  WDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQ-DAHRLLSGEDVGQDEGATRALG 782
            +  ++  A    ++LQ A  +  QFQ  + D +AWL            +        +L 
Sbjct: 2781 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLI 2840

Query: 783  KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ--ALRELYQQVVAQADLR 840
            K HKDF + L     + E    + +    + + S     +LQ   ++  +     Q   R
Sbjct: 2841 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2900

Query: 841  QQRLQEALDLYTVFGE-TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKT 899
            + +L+E+L+    + E  +    W+ + +  L E++      + E    +   L +EM  
Sbjct: 2901 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960

Query: 900  LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNY 959
                ++ +N  ANSL+         V      L  +       +  ++  +++  +    
Sbjct: 2961 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK- 3019

Query: 960  CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK----LSGLERDVAAIQARVDALE 1015
              + +E SK    + +  +   D+  D  G  A   K    L   ++ + A++ +VD  +
Sbjct: 3020 --EFQEVSKESKRQLQCAKEQLDI-HDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3076

Query: 1016 RESQQLMDSHPEQK--EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDF 1073
            R +Q L+    + K   D+  + + + +    L Q +        + S L+  LQ +  F
Sbjct: 3077 RLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD------EKCSFLETKLQGIGHF 3130

Query: 1074 QAWL--SITQKAVASEDMPESLP---EAEQLLQQHAGIK---DEIDGHQDSYQRVKESGE 1125
            Q  +    +Q A   +++    P   +AE L +Q   IK    +++    S     ++ +
Sbjct: 3131 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3190

Query: 1126 KVI-QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCL-GFQEFQKDAKQAEAI 1183
             ++   +T P+ + + + LE L    N L    ++R   +   +   +EF    K+   +
Sbjct: 3191 MMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSIL 3250

Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
            L   E    H E    +      I +  +     +    + L         + +G + S 
Sbjct: 3251 LQKAE---EHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA 3307

Query: 1244 KIKEKVQLIED-------RHRKNNEK-AQEASVLLRDNLELQNFLQNCQELTLWIND--K 1293
                  Q +E        R +  N+K AQ A+ L    L    F    + L  W+ D  +
Sbjct: 3308 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3367

Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL-MDEKPQFTALVSQ 1352
            L+ +Q     E + +  +  + +     L   +  +E I  EG+++    +P     + +
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3427

Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTH---ADLNKWISAMEDQLRSDDP-G 1408
            +L  L   W+ L    K +T++      S +  Q H     LN+W++ +E +L + +P G
Sbjct: 3428 QLSLLDSRWEAL--LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3485

Query: 1409 KDLTSVNRMLAKLKRVEDQVNVRKEELGEL--FAQVPSMGEEGGDADLSIEKR------F 1460
               + +   +A+ K +ED +    + L +     Q   +     D D+   K       +
Sbjct: 3486 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3545

Query: 1461 LDLLEPLGRRKKQLESSRAKLQISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLF 1516
            +++ E    R + L+ +    +I  + E E + W   V ++L      DY T     Q  
Sbjct: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ-- 3603

Query: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEID-CQDLEERLGHLQSSWDRLREAAAG 1575
              + + LQ +IL     V+  L  G +L++    D    ++++L  +++ +  + + +  
Sbjct: 3604 QSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3663

Query: 1576 RLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISDE--IPKDEEGAIVM-----LKRHL 1627
              + L  A + A++ +   +E   W+ + E+ ++S E  + K EE +        LK+  
Sbjct: 3664 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3723

Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
            +  +A+ D   ++ +++S    L+     EG  + ++  + ++ Y  + D   ++  +++
Sbjct: 3724 KNNKALLD---SLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEID 3778

Query: 1688 NMYHLFQLKRETDDLE-QWISEKE-LVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQE 1745
                  Q   +  D E  WI+E E  + S  ++  + D  +      + F  E       
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME------- 3831

Query: 1746 RVDNVNAFIERLIDAGHS-EAATIAEWKDGLNEMWADLLELIDT--------RMQLLAAS 1796
             +      I+ L+ +GH    A   E K  + +    +L+  DT         +QL  A 
Sbjct: 3832 -ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3890

Query: 1797 YDLHRYFYTGAEILGLIDEKH---RELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
              +++++ T  E+   + E      +LP    L+  T       H      +      + 
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAP-ALEYETLRQQQEEHRQLRELIAEHKPHID 3949

Query: 1854 QFQDVATRLQTAYAGE---------KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD 1904
            +      +L     GE          A+ + ++ +E        LD    + TQ  D  D
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4009

Query: 1905 KFRFFSMARDLLSWMESIIRQIETQERPRDVSS----VELLMKYHQGINAEIETRSKNFS 1960
            +             +ES+ R +E   +P  +S+    ++  +  ++ ++ ++E     + 
Sbjct: 4010 QI------------LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYE 4057

Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
               + GE ++ R     ++I  K  Q      +  ++    WE +  L+E     R+A +
Sbjct: 4058 TLKQRGEEMIARSGGTDKDISAKAVQ------DKLDQMVFIWENIHTLVE----EREAKL 4107

Query: 2021 AEAWLIAQE 2029
             +   +A++
Sbjct: 4108 LDVMELAEK 4116



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 157/754 (20%), Positives = 293/754 (38%), Gaps = 78/754 (10%)

Query: 307  YSGLASDLLTWIEQTIT-VLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
            + G   DL  W+  T   +L S+         ++QL        +E    F+ K      
Sbjct: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH-----MEVCAAFEAKEETYKS 4499

Query: 366  LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLAR 425
            L     +M A   K    +  + ++++   WES+E     R+  L   L        LA 
Sbjct: 4500 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL-------NLAM 4552

Query: 426  RFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDL 484
             F         WL++  Q L         L  V     +H+    +  ++ E++  L+  
Sbjct: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612

Query: 485  AQELEKENYHDQKRITARKDNIL----RLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
               L+   Y  QK+      N+L      W  + + L  R + L+      K F +    
Sbjct: 4613 GTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4669

Query: 541  I-DWMDEIKAHLLSA-EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGK 598
            + +W++E +  L S  E      +++  L +HK  +  +  +   V   T  T +  + K
Sbjct: 4670 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK-HSVYDTTNRTGRSLKEK 4728

Query: 599  GYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAE-SWIKEKE 657
                 D   + D +S L   ++ +   +  R+ +LE++      F +  +A   W+   E
Sbjct: 4729 TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4788

Query: 658  -QIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEA 716
             Q+        D+  V+ L   HKAF+ EL    + ++ + + A  ++   +     ++ 
Sbjct: 4789 PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV 4848

Query: 717  RIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHRLLSGEDV-GQD 774
            +++E+S +W+ +  L+   +  L+ A     +F      L  WL +A + L    V   D
Sbjct: 4849 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4908

Query: 775  EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD----VTHRLQALRELY 830
            E A R L  +HK+F+++LEE R  +   +    G        PD    + H +  +R  +
Sbjct: 4909 EDALRTLIDQHKEFMKKLEEKRAELN--KATTMGDTVLAICHPDSITTIKHWITIIRARF 4966

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME---MPDTLEDLEVV 886
            ++V+A A   QQRL  AL       E  +A   W+   E  L + +   +P  +E+++ +
Sbjct: 4967 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5026

Query: 887  QHRFDILDQEMKTLMTQIDGVN-----------------------------LAANSLVES 917
                    +EM      +D V                                A+SL  S
Sbjct: 5027 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5086

Query: 918  GHPRSREVKQYQDHLN-TRWQAFQTLVSERREAVDSAL-------RVHNYCVDC--EETS 967
            G     E K  + +L  ++WQ    L  ERR  ++ AL          N+  D   ++  
Sbjct: 5087 GSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYM 5146

Query: 968  KWIT-DKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
            +W+   K++V++  + + +D  G I  Q  + G+
Sbjct: 5147 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5180



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 59/292 (20%), Positives = 127/292 (43%), Gaps = 27/292 (9%)

Query: 515 ELLQSRRQRLETTLALQKLFQDMLHS------IDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
           +L+Q R+  L+++L  Q L ++ ++       ++W+DE++  L   E+G  L  VE  L+
Sbjct: 620 KLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE 679

Query: 569 KHK-----LMEADIAIQGDKVKAIT-AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEEL 622
            HK     + E + +++  K+  I   A LK T              +++  LE  + +L
Sbjct: 680 NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA------------EKLHRLESQYAKL 727

Query: 623 SNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF 682
            N +  ++  L+    L  F         W+ EKE+   + D+ +  T++   +  H   
Sbjct: 728 LNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL 784

Query: 683 EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
             EL   + +++ + + A  ++         IEA    +  QW  +  L    ++++++ 
Sbjct: 785 MRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN 844

Query: 743 ENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEE 794
             +F+F  DA +   +L++    +  +       +   L    ++ +EE EE
Sbjct: 845 TAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 896



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 68/313 (21%), Positives = 135/313 (43%), Gaps = 39/313 (12%)

Query: 293 VIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEK 352
           ++D  +  E++  K+     DLL W+++    L+  ++ + L  V+  L+    ++ V +
Sbjct: 633 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE---NHKNVHR 686

Query: 353 PPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRN 412
             +  E    E  +  IQ  M A  +  Y     +L            E++Y +   L N
Sbjct: 687 AIEEFESSLKEAKISEIQ--MTAPLKLTYAEKLHRL------------ESQYAK---LLN 729

Query: 413 ELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA--VEAAKKK--HEAIE 468
               QE+       F  +A     WL+E +    ++   YD +      A+KK  H  + 
Sbjct: 730 TSRNQERHLDTLHNFVSRATNELIWLNEKE----EEEVAYDWSERNTNIARKKDYHAELM 785

Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
            +    EE +++++++A++L  EN+  +  I A +  +   WS++ +L Q   Q ++   
Sbjct: 786 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 845

Query: 529 ALQKLFQDMLHSIDWMDEIKAHL---LSAEFGKHLLEVEDLLQ-----KHKLMEADIAIQ 580
           A  + F D   + D++  +K  +    S +    + ++EDL+Q     K +L++    I 
Sbjct: 846 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 905

Query: 581 GDKVKAITAATLK 593
               KA T   LK
Sbjct: 906 NLMGKAKTIIQLK 918



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 48/248 (19%), Positives = 103/248 (41%), Gaps = 11/248 (4%)

Query: 1599 WIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL-ASRAQGLLSAGHPE 1657
            W+ E ++ +   E   D       L+ H    RA+E++  ++K+   S  Q         
Sbjct: 654  WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTY 713

Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
             E++ RL+ Q    YA L + +  ++R L+ +++   + R T++L  W++EKE    + +
Sbjct: 714  AEKLHRLESQ----YAKLLNTSRNQERHLDTLHNF--VSRATNEL-IWLNEKEEEEVAYD 766

Query: 1718 MGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNE 1777
              +   ++   +D   +  RE     +E + +V    E+L+   H    TI  ++  +  
Sbjct: 767  WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 825

Query: 1778 MWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRV 1837
             W+ +L+L     Q +  +     +F    E    +      +      D S+  S H++
Sbjct: 826  QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS--SIHKL 883

Query: 1838 HTAFEREL 1845
                +  +
Sbjct: 884  EDLVQESM 891



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 147/816 (18%), Positives = 311/816 (38%), Gaps = 106/816 (12%)

Query: 1249 VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNL 1308
            +Q +E   RK  E   E S  L   L  Q  L +  E+      K+   Q  +   +  +
Sbjct: 1346 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATV 1402

Query: 1309 HNKWLKHQAFVAELASHEG-------WLENIDAEGKQLMDEKPQFTALVSQKLE------ 1355
             +  L+   + A + S +           + D   ++ MD + ++TALV+   +      
Sbjct: 1403 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1462

Query: 1356 -ALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLR-SDDPGKDLTS 1413
             +L RL +E ++  +EK +H+  A+          +L KW+S +   L+ ++  GK   S
Sbjct: 1463 DSLKRLEEEEKSLEEEKKEHVEKAK----------ELQKWVSNISKTLKDAEKAGKPPFS 1512

Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
                  K K   ++++ +KE+L E    +     + GD     E+  L+      +    
Sbjct: 1513 ------KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1566

Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH--- 1530
            L  S +  Q+        + VEE++   +  +Y   LQ +   + +    +N ++GH   
Sbjct: 1567 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQT---ENRLIGHQEA 1623

Query: 1531 ------TPRVEDVLQRGQQLVEAAEIDCQDLEERL----GHLQSSWDRL-REAAAGRLQR 1579
                  T  ++    + ++L +  +   Q L E +      L+ + ++L +E  A   Q+
Sbjct: 1624 FMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQK 1683

Query: 1580 LRDAN-EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR 1638
            L +A  + +Q  L A++++  + +     I +E  K    A+  L+    +   + D+  
Sbjct: 1684 LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK--VAAVKQLEESKTKIENLLDWLS 1741

Query: 1639 NIKQLASRA---------QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
            N+ + + RA         Q        +G+  I  + +V+ +     DV  +     EN+
Sbjct: 1742 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-TDVDGQVGTTQENL 1800

Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
               +Q  +     E+ IS+ + V  + +  Q      LL  + +  + E     Q+ +  
Sbjct: 1801 NQQYQKVKAQH--EKIISQHQAVIIATQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKE 1853

Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
            +    E  +     +       ++ L +  AD  E       L  +  +L        +I
Sbjct: 1854 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF---EHWLQQSEQELENLEAGADDI 1910

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869
             GL+ +  R+            +SF     + + +L  + +   +  + A        G+
Sbjct: 1911 NGLMTKLKRQ------------KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958

Query: 1870 -----KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR-DLLSWMESII 1923
                     +Q K    +  +++L   C      L D  DK++ +  A   LL+ +++  
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018

Query: 1924 R----------QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
                        ++ +   R +   + L          +E   K     L+   SLL   
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL--- 2075

Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLL 2009
              A  +I++ L  ++ R +++++    R E+L++ L
Sbjct: 2076 -PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2110



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 136/759 (17%), Positives = 292/759 (38%), Gaps = 123/759 (16%)

Query: 964  EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
            ++   W+ D+ +V     + G DL  + +       + R +   ++ +   E +  ++  
Sbjct: 649  QDLLNWV-DEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK--EAKISEIQM 705

Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
            + P  K    ++   LE  +  L  + + QE  L     L  F+    +   WL+  ++ 
Sbjct: 706  TAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEE 761

Query: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
              + D  E      +    HA +  E+D  +++ + V+E  E+++  +  P  L +    
Sbjct: 762  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL-ENHPARLTIEAYR 820

Query: 1144 EGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAA 1203
              + T W+ + ++ +     + +   + EF  DAK+A   L N +  +      D     
Sbjct: 821  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCD----R 876

Query: 1204 EAGIRKFEDFLGSMENNRDKVLS-------------------------PVDSGNKLVA-- 1236
             + I K ED +      ++++L                          P+ +   + A  
Sbjct: 877  SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAIC 936

Query: 1237 -----EGNLYSDKIKEKVQLIEDRHR-------KNNEKAQEASVLL------RDNLELQN 1278
                 E  +Y D   ++  L  + HR           +A   SV        ++ ++L N
Sbjct: 937  DYRQIEITIYKD---DECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN 993

Query: 1279 FLQNCQE--LTLW----INDKLLTSQDVSYDEARNLHNKWL---------KHQAFVAELA 1323
             ++   +  LTLW    IN K + S     +E   +    +         +HQ  ++ L 
Sbjct: 994  RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQ 1053

Query: 1324 SH-EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ-------HL 1375
            S  E +LE  D++  Q+          + +++    + + EL  + + + Q       ++
Sbjct: 1054 SRFEDFLE--DSQESQVFSGSD--ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI 1109

Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKD---LTSVNRMLAKLKRVEDQVNVRK 1432
            S  R+  LRL+   D  + I  +   L  DD  +    +T   ++  +L+R++D +    
Sbjct: 1110 SEVRNIRLRLENCED--RLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 1167

Query: 1433 EELGELFAQ------VPSMGEE------GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480
             +  E F+Q      VP++  E        +   S+   ++D L+ +    K  +++ A 
Sbjct: 1168 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1227

Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
            +++      ET   EE   +A       N++ +   +K+ ++  +E       +ED LQ+
Sbjct: 1228 VKLY-----ETKLCEEEAVIADK----NNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1278

Query: 1541 GQQL-------VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
             + +        +  ++D    +E+   L   W  +      RL+ L    ++ +YY D 
Sbjct: 1279 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1338

Query: 1594 -DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQR 1631
                + WI  Q++     +I +++      L   L QQ+
Sbjct: 1339 YHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQK 1375



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 9/224 (4%)

Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV-----EDQVNVRKEELG 1436
            ++ ++   DL  W+  M+ QL   + G DL SV   L   K V     E + ++++ ++ 
Sbjct: 642  EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 701

Query: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEE 1496
            E+    P +     +    +E ++  LL     +++ L++      +SR   +E +W+ E
Sbjct: 702  EIQMTAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN--FVSR-ATNELIWLNE 757

Query: 1497 RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLE 1556
            +     + D+      +      +  L  E+      ++ V +  +QL+         +E
Sbjct: 758  KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 817

Query: 1557 ERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
                 +Q+ W  + +      Q +++     +++ DA EA  ++
Sbjct: 818  AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 861



 Score = 33.9 bits (76), Expect = 1.8
 Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 32/212 (15%)

Query: 1808 EILGLIDEKHRELPE-----DVGLDASTAESFHRVHTAFER-ELHLLGVQVQQFQDVATR 1861
            ++L  +DE   +L       D+    S  E+   VH A E  E  L   ++ + Q  A  
Sbjct: 650  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP- 708

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L+  YA         K   + + +  LL+    +   L DT   F   S A + L W+  
Sbjct: 709  LKLTYA--------EKLHRLESQYAKLLNTSRNQERHL-DTLHNF--VSRATNELIWLNE 757

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
               +    +     +++     YH  +  E++ + +N  +  E+ E LL   H A   I 
Sbjct: 758  KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 817

Query: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
                   + R  M  +W   W     +L++CQ
Sbjct: 818  -------AYRAAMQTQWS--W-----ILQLCQ 835



 Score = 32.0 bits (71), Expect = 6.7
 Identities = 47/286 (16%), Positives = 105/286 (36%), Gaps = 20/286 (6%)

Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
            DL  W+ E ++     E G D   V    +  ++  R            +  F   L +A
Sbjct: 650  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA-----------IEEFESSLKEA 698

Query: 1761 GHSEAATIAEWK----DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGA-EILGLIDE 1815
              SE    A  K    + L+ + +   +L++T          LH +      E++ L ++
Sbjct: 699  KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 758

Query: 1816 KHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQ 1875
            +  E+  D     +        H    REL      ++  Q++A +L       +   I+
Sbjct: 759  EEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL-TIE 817

Query: 1876 NKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQ---ERP 1932
                 +   W  +L  C      + +    F FF+ A++   ++ ++   I+ +   +R 
Sbjct: 818  AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS 877

Query: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASE 1978
              +  +E L++       E+       +  +   ++++Q + + S+
Sbjct: 878  SSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 923


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  298 bits (763), Expect = 4e-80
 Identities = 172/388 (44%), Positives = 234/388 (60%), Gaps = 15/388 (3%)

Query: 48  LADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGK 107
           +ADER+ VQKKTFTKW+N HL +V   + DLY+DLRDG  LI LLEVLSG+ LP+  KG+
Sbjct: 207 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 265

Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ 167
           MR H L+NV  AL +LK ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V  +
Sbjct: 266 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 325

Query: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKD 227
              E  SAK+ LLLW Q  T GY  +   NFT+ W+DG  FNA+IHK+RPDLID + +  
Sbjct: 326 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 383

Query: 228 SNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEG 287
            +   NLEHAF VAE+ +G+I LLDPEDV   +PDEKS+ITYV + Y  F K   +   G
Sbjct: 384 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK---VPEGG 439

Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTY 347
           + +G     A + E    +Y  + + L+ WI   +T ++ R F N+   ++     +  +
Sbjct: 440 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 494

Query: 348 RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRE 407
           +  E PPK  EK  ++ L   ++  +     K+     G   +DI + W  L  A   RE
Sbjct: 495 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 551

Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRE 435
            ALR E+ R E L+Q+A R  R + + E
Sbjct: 552 KALRPEVERLEMLQQIANRVQRDSVICE 579



 Score =  171 bits (432), Expect = 9e-42
 Identities = 321/1659 (19%), Positives = 676/1659 (40%), Gaps = 141/1659 (8%)

Query: 387  KLVSDINRAWESL-EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRL 444
            K +S ++  WE+L  +AE R          + E +  +A++F         WL+   +RL
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNR--------QLEGISVVAQQFHETLEPLNEWLTTIEKRL 3616

Query: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
            V  +  G   + +E    +H+A+E D   + + +     + Q L+  +  + K +   K 
Sbjct: 3617 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3676

Query: 505  NILRLWSY-LQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEIKAHLLSAEFGKHLLE 562
            +  ++W   +QE   SR + L+  L   K+F +D +  ++W++E+   L       +  E
Sbjct: 3677 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3736

Query: 563  VEDLLQKH-KLMEADIAIQGDKVKAITA---ATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
                 Q   ++++ DI ++   V          LK T G      +  +IQD++  ++  
Sbjct: 3737 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGD-----EVLIIQDKLEAIKAR 3791

Query: 619  FEELSNMAAGRKAQLEQSKRLWKFFWEM-DEAESWIKEKEQIYSSLDY----GKDLTSVL 673
            +++++ ++      LEQ+ +L +      +E  +W+ + E    S +     G++ +   
Sbjct: 3792 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA- 3850

Query: 674  ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQLKDLA 732
              Q + K  + E +   A L+ + + +  ++    +     +E  + E + ++  + D  
Sbjct: 3851 --QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3908

Query: 733  AFCKKNLQDAE-NFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKHKDFLE 790
                + +  A     QF   AD   +W+ +  + L+S  D+  ++  T A  +  K F  
Sbjct: 3909 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3968

Query: 791  ELEESRGVMEHLEQQAQGF----PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
            E+   + +++ L +          EE + S  +  +L  + + Y  +      R  +L+ 
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLER 4026

Query: 847  ALDLYTVFGET-DACELWMGEKEKWLAEMEMPDT-LEDLEVVQHRFDILDQEMKTLMTQI 904
            A  L   F ET +    W+ E +  ++++  P    E L   Q     L + +      I
Sbjct: 4027 AQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 4086

Query: 905  DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
            D +N     L+E        +++     +T +   +  V +R  A+D A+       D  
Sbjct: 4087 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD-- 4144

Query: 965  ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLS---GLERDVAAIQARVDALERESQQL 1021
            +  + +    ++VE  +      A +  I+ ++S    +  D+  +Q   + L++  +++
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 1022 MDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-QAFLQDLDDFQA 1075
            +       +DI  +  Q  L+++   W+ +   ++ +E  L +V +L + F  D      
Sbjct: 4205 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4264

Query: 1076 WLSITQKAVASEDMPESLPEAEQLLQQHAG-IKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134
             +  TQ  +   + P   P   +  Q+ A  I++EIDG Q+    V   G ++I    +P
Sbjct: 4265 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4324

Query: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAE-AILSNQEYTLAH 1193
            +  ++ + ++ L++ W++L + W+ R   L + +      +D  QA    +      LA 
Sbjct: 4325 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLAS 4384

Query: 1194 LEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-------- 1244
            + P    LE  +  I + + F       + ++         L+ +    SDK        
Sbjct: 4385 MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLM 4444

Query: 1245 -IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI--NDKLLTSQDVS 1301
             +K     +E+R      K + A       L L  F     EL  W+   + LL+ Q   
Sbjct: 4445 ELKLIWDSLEERIINRQHKLEGAL------LALGQFQHALDELLAWLTHTEGLLSEQKPV 4498

Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP-QFTALVSQKLEALHRL 1360
              + + +  +  KH     ++ +H+  +E ++  G  L++    +  + +  KLE L++ 
Sbjct: 4499 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4558

Query: 1361 WDELQATTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDP-------GKDLT 1412
            W  +   T+++ Q L  A R +        DL +W++  E  L +  P        K+  
Sbjct: 4559 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4618

Query: 1413 SVN-RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL-SIEKRFLDLLEPLGRR 1470
            +V+  + A  +  E+      ++  ++ A+ P   E   D D+ ++++++  +   L  R
Sbjct: 4619 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4678

Query: 1471 KKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
            K +LE +    ++    L+D   W+   E+ L +A        L TV   + +++   NE
Sbjct: 4679 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP--SLILDTVLFQIDEHKVFANE 4736

Query: 1527 ILGHTPRVEDVLQRGQQL-VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE 1585
            +  H  ++ ++ + G  L   + + D   ++  L  +QS W+++ +    R + L DA +
Sbjct: 4737 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4796

Query: 1586 -AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQRAV---------- 1633
             A+Q++    +   W+ E E  + S+ EI  D +     L +H   Q+++          
Sbjct: 4797 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4856

Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693
               GR++K+  S A   L       + +  L+ + D     +   + ER+ KLE    L 
Sbjct: 4857 NRTGRSLKEKTSLADDNLKL----DDMLSELRDKWDT----ICGKSVERQNKLEEA--LL 4906

Query: 1694 QLKRETDDLEQWIS-----EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVD 1748
               + TD L+  I      E +L    P  G D D V  L D  + F +E G    +R  
Sbjct: 4907 FSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELG----KRTS 4961

Query: 1749 NVNAF---IERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY----DLHR 1801
            +V A       LI+    +++ +      L+  W  +  L  ++   L A+     + H 
Sbjct: 4962 SVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHS 5021

Query: 1802 YFYTGAEILGLIDEK---HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
              +   E L   ++    H  LP+    D     +    H  F ++L     ++ +   +
Sbjct: 5022 VVHALLEWLAEAEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTM 5077

Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA-----DKFRFFSMAR 1913
               +      +    I++    + A ++ +L A A +  Q + +A      K        
Sbjct: 5078 GDTVLAICHPDSITTIKHWITIIRARFEEVL-AWAKQHQQRLASALAGLIAKQELLEALL 5136

Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
              L W E+ +   + +  P+++  V+ L+  HQ    E+
Sbjct: 5137 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175



 Score =  157 bits (397), Expect = 1e-37
 Identities = 322/1813 (17%), Positives = 717/1813 (39%), Gaps = 209/1813 (11%)

Query: 389  VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
            ++ I   W++  +    RE  L+  L       + A ++  +      W+ + Q  + + 
Sbjct: 3021 LNTIKTNWDTFNKQVKERENKLKESL-------EKALKYKEQVETLWPWIDKCQNNLEEI 3073

Query: 449  NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
             F  D A  E +  K ++++ +   +   V  L + A  L      D++ +T    ++++
Sbjct: 3074 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 3133

Query: 509  LWSYLQELLQSRRQRLETTLALQKLFQDML-----------HSIDWMDEIKAHLLSAEFG 557
                + E L S++  LE      K FQ++              +D  D + +   S ++ 
Sbjct: 3134 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3193

Query: 558  KHLLEVEDLLQ--KH-----KLMEADIAIQGDKVKAITAATLKF-TEGKGYQPCDPQV-- 607
              L   +  LQ  KH     K +  D+ ++    K  +   L+  T  + +     QV  
Sbjct: 3194 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3253

Query: 608  ------------------IQDRISHLEQCFEELSNMA-AGRKAQLEQSKRLWKFFWEMDE 648
                              I++  S   +  +EL +MA  GR A+  Q ++        + 
Sbjct: 3254 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQK--------ET 3305

Query: 649  AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
             ++++K+ E + +S D       +++   +      +L G+   LE + ++ + ++ R Q
Sbjct: 3306 IKAFLKKLEALMASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDRAQ 3362

Query: 709  FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
                Q+E  IK +   + +LK+ +      LQ AE   + QG               +  
Sbjct: 3363 AREEQVEGTIKRLEEFYSKLKEFSIL----LQKAEEHEESQGPVG------------MET 3406

Query: 769  EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD---VTHRLQA 825
            E + Q     +   K      EE+E  +G  + +    QG  +    S     + H L  
Sbjct: 3407 ETINQQLNMFKVFQK------EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3460

Query: 826  LRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLE 884
            +   ++ +  +   R  +LQEAL     F +  ++   WM + E+ +A  + P    + +
Sbjct: 3461 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA--EFK 3518

Query: 885  VVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EVKQYQDHLNTRWQAFQ 940
            VV+ +     +L + +    + ++ +      +  +  P  + ++ +    L++RW+A  
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3578

Query: 941  TLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
                 R   ++  ++    +    E  ++W+T   K + + + +G   + +     +   
Sbjct: 3579 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKA 3638

Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ-GLQQSLQGQEDLLG 1058
            LE D+      +       Q L      + +D+ Q +    ++W   +Q+    + +LL 
Sbjct: 3639 LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQ 3698

Query: 1059 E-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI-KDEIDGHQDS 1116
            + +   + F +D  +   WL+     ++   + +   E     Q    + +++I   + +
Sbjct: 3699 QALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQN 3758

Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ---------- 1166
              +   +G ++++  T  E L++  +LE +   +  + ++    + TL Q          
Sbjct: 3759 VDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHS 3818

Query: 1167 -----CLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
                 C    + + +    E  +L  +E + A + P +  + A    +  +  L S+   
Sbjct: 3819 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA----KNNKALLDSLNEV 3874

Query: 1221 RDKVLSPV-----DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
               +L  V     +   K+VAE N    L SD I +KV+ I+             + +LR
Sbjct: 3875 SSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-------------AAILR 3921

Query: 1272 DNLELQNFLQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
                 Q F Q       WI +   KL++  D+  ++ +      ++ + F  E+  H+  
Sbjct: 3922 S----QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQ-KTFTMEILRHKDI 3976

Query: 1329 LENIDAEGKQLM----DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
            ++++   G ++M    +E+ Q    + +KL+ + + +D +     E+   L  A+S   +
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQ---SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 4033

Query: 1385 L-QTHADLNKWISAMEDQL-RSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV 1442
              +T+ +L  W++  +  + +   P  +  ++ +   + +++ + +   K  + ++    
Sbjct: 4034 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 4093

Query: 1443 PSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
            P + E       SI+++++        + E + +R   L+ + ++     D  D+ L   
Sbjct: 4094 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4153

Query: 1496 ERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA----- 1548
            ER+   L Q       ++ ++  + +N+ +  ++    P  E + QRG++++  +     
Sbjct: 4154 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4213

Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYV 1607
            +I  + ++++L  +   W+ +      R  +L D  E A++++ D       I + + ++
Sbjct: 4214 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4273

Query: 1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR--------AQGLLSAGHPEGE 1659
               E P  +   +       +QQ A E     I  L           ++ + + G P+  
Sbjct: 4274 RDLEDPGIDPSVV------KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4327

Query: 1660 QIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQW--ISEKELVASSP 1716
             + +   +++  +  L    ++R  KLE  M    Q +     +  W  I+  +L + SP
Sbjct: 4328 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4387

Query: 1717 EMGQDFDHVTLLRDKFRDFARET--GAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDG 1774
             +G D + V    ++ + F  E     I  ER+++    + + +    S+  T+ +    
Sbjct: 4388 -IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV-TEESDKHTVQDPLME 4445

Query: 1775 LNEMWADLLE-LIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPED--VGLDASTA 1831
            L  +W  L E +I+ + +L  A   L ++ +   E+L  +      L E   VG D    
Sbjct: 4446 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505

Query: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
            E     H   + ++      V+        L  + AGE+A  +QNK + ++  WQ +L+ 
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565

Query: 1892 CAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYHQGIN 1949
               R+ QL     + + F     DL  W+    R +   +    +  + +  +  H  + 
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4625

Query: 1950 AEIETRSKNFSACLELGESLLQRQHQASE--------EIREKLQQVMSRRKEMNEKWEAR 2001
            A  E + + + + ++ G+ +L R  +++E         ++EK + V ++  E   K E  
Sbjct: 4626 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE-- 4683

Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYL-ASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
             E L + +E   F         WL   E  L  +      +D+V   I  H+ F     S
Sbjct: 4684 -EALNLAME---FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4739

Query: 2061 WAERFAALEKPTT 2073
              E+   L+K  T
Sbjct: 4740 HREQIIELDKTGT 4752



 Score =  155 bits (393), Expect = 3e-37
 Identities = 308/1553 (19%), Positives = 632/1553 (40%), Gaps = 124/1553 (7%)

Query: 606  QVIQDRISHLEQCFEELSNMAAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLD 664
            Q ++  +  +   ++ L+   A R AQL+++     +F   ++   SW+ + E++ ++  
Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511

Query: 665  YGKDLTSVLILQ-RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHP-QIEARIKEVS 722
                   V+  Q ++ K  +  L    + +E I +E   +    +     +I  ++  + 
Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3571

Query: 723  AQWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAH-RLLSGEDVGQDEGATRA 780
            ++W+ L + A    + L+      Q F    + L  WL     RL++ E +G        
Sbjct: 3572 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3631

Query: 781  LGKKHKDFLEELEESRGVMEHLEQ-----QAQGFPEEFRDSPDVTHRLQALRELYQQVVA 835
               +HK   +++       +HL Q     Q+        D   V  +L   +  Y ++  
Sbjct: 3632 QIAQHKALEDDIINHN---KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688

Query: 836  QADLRQQRLQEALDLYTVFGETDACEL--WMGEKEKWLAEMEMPD-TLEDLEVVQHRFDI 892
            ++  R + LQ+AL    +FGE D  EL  W+ E    L+++ + D + E L   Q    +
Sbjct: 3689 KSHSRSELLQQALCNAKIFGE-DEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3747

Query: 893  LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNT---RWQAFQTLVSERREA 949
            L +++      +D   L    L++       EV   QD L     R++    L ++  + 
Sbjct: 3748 LQEDILLRKQNVDQALLNGLELLKQ--TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805

Query: 950  VDSAL----RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKL--SGLERD 1003
            ++ AL    R+H+     EE   W+ DK +V E      + L G  A Q ++    L+++
Sbjct: 3806 LEQALQLARRLHS---THEELCTWL-DKVEV-ELLSYETQVLKGEEASQAQMRPKELKKE 3860

Query: 1004 VAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQSL-QGQEDLLGEVS 1061
                +A +D+L   S  L++  P   +E + +      E ++ +  ++ Q  E++   + 
Sbjct: 3861 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3920

Query: 1062 QLQAFLQDLDDFQAWLSITQKAVAS-EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRV 1120
            + Q F Q  D   +W++ T+K + S  D+     +    LQ       EI  H+D    +
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3980

Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGF-QEFQKDAKQ 1179
             +SG K++   ++ E   + ++L+ +   ++ + ++   R   L +      +F +  ++
Sbjct: 3981 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 4040

Query: 1180 AEAILSNQEYTLAHLEPP----DSLEAAEAGIRKFEDFLGSMENNRDKV---------LS 1226
                L+  +  ++ L  P    ++L   +   R+  + +   + + DK+         LS
Sbjct: 4041 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 4100

Query: 1227 PVDSGN---KLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNC 1283
            P +  +   K VA   LYS +IKE V+          ++A      +  + +  + +   
Sbjct: 4101 PGEGFSIQEKYVAADTLYS-QIKEDVK----------KRAVALDEAISQSTQFHDKIDQI 4149

Query: 1284 QELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM--- 1340
             E    I ++L     +S  E   +  +  +++    ++   +   E +   G++++   
Sbjct: 4150 LESLERIVERLRQPPSISA-EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4208

Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEK-TQHLSAARSSDLRLQTHADLNKWISA 1397
               +K      V  KL+ +  +W+ +    +E+  + L     ++     H  L   I  
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4268

Query: 1398 MEDQLRS-DDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSI 1456
             +D +R  +DPG D + V +     + + ++++  +EEL  +      +    G+ D  I
Sbjct: 4269 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4328

Query: 1457 EKRFLDLLEPL---------GRRKKQLESSRAKLQISRDLEDETLWVE-ERLPLAQSADY 1506
             K+ +D L             R  K  E+ +A +Q    L+    WV+     LA  +  
Sbjct: 4329 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4388

Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQS 1564
            GT+L+TV+  +++ +  ++E       +E +  + + L++    E D   +++ L  L+ 
Sbjct: 4389 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448

Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAEAWIGEQELYVISDEIPK--DEEGAIV 1621
             WD L E    R  +L  A  A   +  A DE  AW+   E  ++S++ P   D +   +
Sbjct: 4449 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE-GLLSEQKPVGGDPKAIEI 4507

Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDV 1678
             L +H   Q  V  +   ++ +      L+ +    GE+   LQ +++   + +  + + 
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS--AGEEASNLQNKLEVLNQRWQNVLEK 4565

Query: 1679 AEERKRKLENMYHLFQ-LKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDF 1735
             E+RK++L+      +    E +DL+QW++  E+ L+AS P  G        L     + 
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL-----NV 4620

Query: 1736 ARETGAIGQERVDNVNAFIER----LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
              E  A  + + +   + +++    L     S    I +  + L E W  +   ++ R  
Sbjct: 4621 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4680

Query: 1792 LLAASYDLHRYFYTGAE-ILGLIDEKHREL--PEDVGLDASTAESFHRVHTAFERELHLL 1848
             L  + +L   F+   +  +  + +  + L       L   T       H  F  E++  
Sbjct: 4681 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4740

Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
              Q+ +     T L+     +    I+N    V + W+ ++     R   L D   + + 
Sbjct: 4741 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4800

Query: 1909 FSMA-RDLLSWMESIIRQIETQ-ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELG 1966
            F  A   L+ W+E   + ++++ E   D   ++  +  H+     +  +   +      G
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860

Query: 1967 ESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAE 2022
             SL ++   A + +  KL  ++S   E+ +KW+       ER   L E   FS   + A 
Sbjct: 4861 RSLKEKTSLADDNL--KLDDMLS---ELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915

Query: 2023 A----WLIAQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
                 WL   EP LA     H  +D V  LI  H+AF+K          AL++
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968



 Score =  149 bits (375), Expect = 4e-35
 Identities = 358/1838 (19%), Positives = 731/1838 (39%), Gaps = 212/1838 (11%)

Query: 359  KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE 418
            K   EVLL    S + A N    T  D  +V       +S+ E   + ++ L   L  Q+
Sbjct: 2199 KKTAEVLLDARGSLLPAKNDIQKTLDD--IVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2256

Query: 419  KLEQLARRFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEER 477
             L+++             W+      L  Q     +  A++    K+  +E D A  +  
Sbjct: 2257 GLDEML-----------DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2305

Query: 478  VRALEDLAQE-LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
            + A+ +  ++ +E  +      + A+  ++   +S      +    ++E      +LF++
Sbjct: 2306 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2365

Query: 537  MLHSIDWMDEIKAHLLSAEF--GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
            +   +    E K   L+     GK + E+   +Q+         ++  K   +  + LK 
Sbjct: 2366 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQE----STSEFLEHKKHLEVLHSLLKE 2421

Query: 595  TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKFFWEMDEAESWI 653
                G  P D  ++ ++ ++L + F+E+ +    +K  +    ++L  F   +   +SWI
Sbjct: 2422 ISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWI 2480

Query: 654  KEK-------EQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------LEQIFQE 699
            KE        +  + + D GK L     LQ K      E++ ++         +  +   
Sbjct: 2481 KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP 2540

Query: 700  AHGMVARKQFGH--------------------PQIEARIKEVSAQWDQL----KDLAAFC 735
            A  + A K  G                       I+  + ++S  ++ L    KD  A  
Sbjct: 2541 AKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAEL 2600

Query: 736  KKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEGATRALGKKHKDFLEEL 792
               L   +   + Q ++  +  WLQ  ++  +         D  A +   +++K F  EL
Sbjct: 2601 NTKLSKLQ---KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2657

Query: 793  EESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALD 849
            +++   ++ L+ +     EE  D+P+     Q L E+   +Q++      RQQ+L+E+ +
Sbjct: 2658 KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSN 2717

Query: 850  LYTVFGETDA-CELWMGEKEKWLAEMEMPDTLED--LEVVQHRFDILDQEMKTLMTQIDG 906
              T F   +A  + W+ EKE  ++ +  P +++   L   + +  IL QE  T   Q + 
Sbjct: 2718 NLTQFQTVEAQLKQWLVEKELMVSVLG-PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2776

Query: 907  VNLAANSLVES-GHPRSRE--VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDC 963
            +  A   ++   G   S    VK+    +  +W +    +S+R + +D A+         
Sbjct: 2777 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAI--------- 2827

Query: 964  EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
             +++++ +    + +   DL   L+  +A+      + + +   Q     +++E +Q+  
Sbjct: 2828 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2887

Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQG--------QEDLLGEVSQLQA-------FLQ 1068
            +     ED+    K  E L   L + L+G        ++     V  LQ+       F Q
Sbjct: 2888 AQA-LCEDLSALVKE-EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2945

Query: 1069 DLDDFQAWLSITQKAVASEDMPES--LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEK 1126
               DFQAWL  T+K   ++  P S  L   E L++ H      +      Y++    GE 
Sbjct: 2946 MSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN 3004

Query: 1127 VIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI--- 1183
            ++      E   L  +L  + T W+   +  + R + L + L  ++  K  +Q E +   
Sbjct: 3005 LLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL--EKALKYKEQVETLWPW 3062

Query: 1184 -------LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NNRDKVLSPVDSGNK 1233
                   L   ++ L   E  +S+   ++  ++ +   G +E   N  + +LS  +   +
Sbjct: 3063 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 3122

Query: 1234 LVAEGNLYSDKIKEKVQLI-EDRHRKN---NEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
            +V + N     + +KV ++ E  H K        Q+       + E +  LQ C +  L 
Sbjct: 3123 VVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ-CAKEQLD 3178

Query: 1290 INDKL----LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ 1345
            I+D L     +++ ++  + +    + LKHQ  +A+  + +  +E  D++G         
Sbjct: 3179 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--------- 3229

Query: 1346 FTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS 1404
             T+ V  ++E + +    L     EK   L          Q T  ++    +  +D+L S
Sbjct: 3230 -TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDS 3288

Query: 1405 DDP-GKDLTSVNR----MLAKLKRVE----DQVNVRKEELGELFAQVPSMGEEGGDADL- 1454
              P G+D  ++ +    + A LK++E       N  K     L  +  S    G   DL 
Sbjct: 3289 MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLE 3348

Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKLQ--ISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
            ++ K+   LL+    R++Q+E +  +L+   S+  E   L  +           G   +T
Sbjct: 3349 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3408

Query: 1513 VQLFMKKNQTLQ-NEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRL 1569
            +   +   +  Q  EI     + +DV   GQ L+++A      Q LE  L  + + W  L
Sbjct: 3409 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3468

Query: 1570 REAAAGRLQRLRDANEAQQYYLDADEA-EAWIGEQELYVISDEIPKDEEGAI-VMLKRHL 1627
             +  A R  +L++A      + DA E+  +W+ + E  V + + P  E   +   ++   
Sbjct: 3469 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3528

Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGE-QIIRLQGQVDKHYAGLKDVAEERKRKL 1686
              QR ++D    ++ +    + + +   P  + +I++    +D  +  L + AE R R+L
Sbjct: 3529 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3588

Query: 1687 ENMYHLFQLKRET-DDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
            E +  + Q   ET + L +W++  EK LV   P        +     K  +   +  A+ 
Sbjct: 3589 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP--------IGTQASKLEEQIAQHKAL- 3639

Query: 1744 QERVDNVNAFIERLIDAGHS-------EAATIAEWKDGLNEMW-ADLLELIDTRMQLLAA 1795
            ++ + N N  + + +  G S       E   + + K   +++W  ++ E   +R +LL  
Sbjct: 3640 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3699

Query: 1796 SYDLHRYF-YTGAEILGLIDEKHRELPEDVGLDASTAESFHRVH--TAFERELHLLGVQV 1852
            +    + F     E++  ++E H +L +    D ST   + +       + ++ L    V
Sbjct: 3700 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3759

Query: 1853 QQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-----R 1907
             Q       L     G++   IQ+K + + A ++ +        T +  T ++      R
Sbjct: 3760 DQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL----STDVAKTLEQALQLARR 3815

Query: 1908 FFSMARDLLSWMESI---IRQIETQE-RPRDVSSVELLMKYHQGINAEIETRSKNFSACL 1963
              S   +L +W++ +   +   ETQ  +  + S  ++  K       E++  +KN  A L
Sbjct: 3816 LHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-------ELKKEAKNNKALL 3868

Query: 1964 ----ELGESLLQR-QHQASEEIREKLQQVMSRRKEMNEKWEARWERL-RMLLEVCQFSRD 2017
                E+  +LL+    +A E + + + +   R + +++    + E +   +L   QF + 
Sbjct: 3869 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3928

Query: 2018 ASVAEAWLIAQEPYLAS-GDFGHTVDSVEKLIKRHEAF 2054
            A    +W+   E  L S GD     D     ++  + F
Sbjct: 3929 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3966



 Score =  129 bits (325), Expect = 2e-29
 Identities = 389/2030 (19%), Positives = 780/2030 (38%), Gaps = 278/2030 (13%)

Query: 277  FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSG--LASDLLTWIEQTITVLNSRK---FA 331
            FSK K+ + E     + +  A++T ++     G  +  +    +E+ +  L       F+
Sbjct: 1649 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1708

Query: 332  NSLTGVQQQLQAFSTYRTV--------EKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTP 383
             SL    +QLQ   T   V        E+  +++EK      L T        +Q+ +  
Sbjct: 1709 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1764

Query: 384  HDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
             DG +              E ++  + + EL  Q+ ++  A+         E +L EN  
Sbjct: 1765 GDGTV--------------ELKKYQSKQEEL--QKDMQGSAQALAEVVKNTENFLKENGE 1808

Query: 444  LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
             ++Q++       +  AK K E +       ++ +  +   A + E E     K++   K
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1868

Query: 504  DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH--------SIDWMDEIKAHLLSAE 555
              I  L  +L  +   +      T   Q + Q+  H        +I   DE+  +LL  +
Sbjct: 1869 TKIENLLDWLSNV--DKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1926

Query: 556  FGKHLLEVEDLL----QKHKLMEADIAIQGDKVKAIT--AATLKFTEGKGYQPCDPQVIQ 609
                +   ++ L    QK K     I  Q   V   T  A  L   +G+   P + + +Q
Sbjct: 1927 VDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ 1986

Query: 610  DRISHLEQCFEE-LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYG-K 667
              +  L+  +E  L+      K      + L KF  +  E E W+++ EQ   +L+ G  
Sbjct: 1987 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046

Query: 668  DLTSVLILQRKHKAFEDELRGLDAHLEQI------FQEAHGMVARKQFGHPQIEARIKEV 721
            D+  ++   ++ K+F +++      L  I        EA    +++  G     A  +EV
Sbjct: 2047 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 2106

Query: 722  SAQWDQLKD----LAAFCK---KNLQDAENFFQFQGDAD-DLKAWLQDAHRLLS---GED 770
              + D   D    L + C     NL+D  + +Q   DA   L A LQ      S    E 
Sbjct: 2107 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2166

Query: 771  VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE----FRDSPDVTHRLQAL 826
            +  D    +   ++ K    ++   +  +E L++ A+   +          D+   L  +
Sbjct: 2167 IAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI 2226

Query: 827  RELYQQVVAQADLRQQRLQEALD-LYTVFGETDACELWMGEKEKWLAEM-EMPDTLEDLE 884
               Y+ +    + R ++LQ  L    +V    D    WMG  E  L E  ++P     L+
Sbjct: 2227 VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ 2286

Query: 885  VVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP----------------------RS 922
             +  +  +L+Q++    + I+ +N      +E+  P                      + 
Sbjct: 2287 DIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKH 2346

Query: 923  REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV-ESTK 981
            +E     + L T+ + F+ L  + +  +++  +      + +   K +T+ ++ + EST 
Sbjct: 2347 KETLAKMEELKTKVELFENLSEKLQTFLETKTQA---LTEVDVPGKDVTELSQYMQESTS 2403

Query: 982  DL---GRDLAGIIAIQRKLS--GLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ 1036
            +     + L  + ++ +++S  GL  D A +  + + L ++ +++ D+  E+KE +   Q
Sbjct: 2404 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQ 2463

Query: 1037 KHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
            + L + +Q L +SL+                  + +    + I Q +  +ED+ +SL + 
Sbjct: 2464 EQL-DAFQVLVKSLKSW----------------IKETTKKVPIVQPSFGAEDLGKSLEDT 2506

Query: 1097 EQLLQQHAGIKDEIDGHQDS----------------YQRVKESGEKVIQGQ---TDPEYL 1137
            ++L ++ +    EI    +S                     +SG  V+ G+   T+ E  
Sbjct: 2507 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2566

Query: 1138 LLGQRLEG-------LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS----- 1185
               + L         +  G+  LG + + +   L   L   + QK  +++ A++      
Sbjct: 2567 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL--SKLQKAQEESSAMMQWLQKM 2624

Query: 1186 NQEYTLAHLEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEG--NLYS 1242
            N+  T     P P   EA +  + + + F   ++ N +KV    D   +L+ E      +
Sbjct: 2625 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2684

Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQ--- 1298
             + K+ +  I+ + ++ N+   +    L ++   L  F     +L  W+ +K L      
Sbjct: 2685 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2744

Query: 1299 DVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD---EKPQFTALVSQKLE 1355
             +S D    L+ +  + Q  + E A+ +   E + A G+ ++    E P    +V ++L 
Sbjct: 2745 PLSID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2803

Query: 1356 ALHRLWDELQATTKEK-----------TQHLSAARSSDLRLQTHADL-NKWISAMEDQLR 1403
            A+ + WD L     ++           TQ+ S  RS   +L   +DL NK  S++     
Sbjct: 2804 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL---SDLDNKLSSSLAVSTH 2860

Query: 1404 SDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLS-----IEK 1458
             D   + L +  +M  ++++ + Q+ V +    +L A V    EE   A+LS     I K
Sbjct: 2861 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK---EEYLKAELSRQLEGILK 2917

Query: 1459 RFLDLLEPLGRRKKQLESSRAK----LQISRDLEDETLWVE-ERLPLAQSADYGTNLQTV 1513
             F D+ +      + L+S+ A      Q+SRD +    W++ ++    +S      L  +
Sbjct: 2918 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVL 2974

Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQ-LVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
            +  +K ++     +   +   E  +  G+  L++    +   L+ +L  ++++WD   + 
Sbjct: 2975 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 3034

Query: 1573 AAGRLQRLRDANE-AQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRH 1626
               R  +L+++ E A +Y    +    WI +     +E+    D  P + E +I  LK  
Sbjct: 3035 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLK-- 3090

Query: 1627 LRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKL 1686
               Q+ ++ +   ++ L + A  LLS    + E +      + +    + +    +K  L
Sbjct: 3091 -SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3149

Query: 1687 ENMYHLFQLKRET--DDLEQWISEKELVASSPEMGQDF---DHVTLLRDKFRDFARETGA 1741
            ENM   F+  +E   +   Q    KE +     +G       ++T+L+ + +        
Sbjct: 3150 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3209

Query: 1742 IGQERVDNVNAFIERLIDAGHS----EAATIAEWKDGLNEMWADLLELIDTRMQLLAASY 1797
            +   +    +  +E     G S    +  TIA+    L++   +    ++T++Q +    
Sbjct: 3210 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3269

Query: 1798 DLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELH-LLGVQVQQFQ 1856
            +  R  +  ++     DE     P  VG DA T +       AF ++L  L+       +
Sbjct: 3270 NTIREMF--SQFAEFDDELDSMAP--VGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3325

Query: 1857 DVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMARDL 1915
                 L T         I+   + +S     LLD    R  Q+  T  +   F+S  ++ 
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3385

Query: 1916 LSWMESIIRQIETQ----ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
               ++      E+Q         ++    + K  Q    EIE           LG+ L+Q
Sbjct: 3386 SILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQ 3443

Query: 1972 --RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQE 2029
               +  +++ +   L  V +R K +N+K   R  +L+  L  C                 
Sbjct: 3444 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC----------------- 3486

Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASW---AERFAALEKPTTLELK-------ER 2079
                    G   D++E L+           SW    E   A +KP + E K       E+
Sbjct: 3487 --------GRFQDALESLL-----------SWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3527

Query: 2080 QIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESL 2129
            ++ +R  ++     E  +  GE   +     ++   +   S L S WE+L
Sbjct: 3528 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3577



 Score =  102 bits (254), Expect = 4e-21
 Identities = 315/1749 (18%), Positives = 686/1749 (39%), Gaps = 177/1749 (10%)

Query: 387  KLVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRFDRKAAMRETWLSENQRLV 445
            K ++DI+  +E L        L L++++     KL +L +  +  +AM + WL +  +  
Sbjct: 2577 KDMTDISHGYEDLG-------LLLKDKIAELNTKLSKLQKAQEESSAMMQ-WLQKMNKTA 2628

Query: 446  A---QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN--YHDQKRIT 500
                Q     D  AV+   +++++ E +      +V+ L+D   EL +EN    +  R  
Sbjct: 2629 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2688

Query: 501  ARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFGKH 559
                 I   W  L +L   R+Q+LE +      FQ +   +  W+  ++  L+ +  G  
Sbjct: 2689 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPL 2746

Query: 560  LLEVEDL---LQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
             ++   L    Q+ +++  + A +  + + +TAA        G  P    +++++++ + 
Sbjct: 2747 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2806

Query: 617  QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
            Q ++ L+   + R   ++Q+        +  + +S ++      S LD    L+S L + 
Sbjct: 2807 QKWDSLTGQLSDRCDWIDQA------IVKSTQYQSLLRSLSDKLSDLD--NKLSSSLAVS 2858

Query: 677  RKHKAFEDELRGLDAHLEQIFQEAH------------GMVARKQFGHPQIEARIKEVSAQ 724
                A   +L       ++I QE                + ++++   ++  +++ +   
Sbjct: 2859 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2918

Query: 725  WDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQ-DAHRLLSGEDVGQDEGATRALG 782
            +  ++  A    ++LQ A  +  QFQ  + D +AWL            +        +L 
Sbjct: 2919 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLI 2978

Query: 783  KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ--ALRELYQQVVAQADLR 840
            K HKDF + L     + E    + +    + + S     +LQ   ++  +     Q   R
Sbjct: 2979 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 3038

Query: 841  QQRLQEALDLYTVFGE-TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKT 899
            + +L+E+L+    + E  +    W+ + +  L E++      + E    +   L +EM  
Sbjct: 3039 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 3098

Query: 900  LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNY 959
                ++ +N  ANSL+         V      L  +       +  ++  +++  +    
Sbjct: 3099 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK- 3157

Query: 960  CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK----LSGLERDVAAIQARVDALE 1015
              + +E SK    + +  +   D+  D  G  A   K    L   ++ + A++ +VD  +
Sbjct: 3158 --EFQEVSKESKRQLQCAKEQLDI-HDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3214

Query: 1016 RESQQLMDSHPEQK--EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDF 1073
            R +Q L+    + K   D+  + + + +    L Q +        + S L+  LQ +  F
Sbjct: 3215 RLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD------EKCSFLETKLQGIGHF 3268

Query: 1074 QAWL--SITQKAVASEDMPESLP---EAEQLLQQHAGIK---DEIDGHQDSYQRVKESGE 1125
            Q  +    +Q A   +++    P   +AE L +Q   IK    +++    S     ++ +
Sbjct: 3269 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3328

Query: 1126 KVI-QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCL-GFQEFQKDAKQAEAI 1183
             ++   +T P+ + + + LE L    N L    ++R   +   +   +EF    K+   +
Sbjct: 3329 MMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSIL 3388

Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
            L   E    H E    +      I +  +     +    + L         + +G + S 
Sbjct: 3389 LQKAE---EHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA 3445

Query: 1244 KIKEKVQLIED-------RHRKNNEK-AQEASVLLRDNLELQNFLQNCQELTLWIND--K 1293
                  Q +E        R +  N+K AQ A+ L    L    F    + L  W+ D  +
Sbjct: 3446 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3505

Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL-MDEKPQFTALVSQ 1352
            L+ +Q     E + +  +  + +     L   +  +E I  EG+++    +P     + +
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3565

Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTH---ADLNKWISAMEDQLRSDDP-G 1408
            +L  L   W+ L    K +T++      S +  Q H     LN+W++ +E +L + +P G
Sbjct: 3566 QLSLLDSRWEAL--LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3623

Query: 1409 KDLTSVNRMLAKLKRVEDQVNVRKEELGEL--FAQVPSMGEEGGDADLSIEKR------F 1460
               + +   +A+ K +ED +    + L +     Q   +     D D+   K       +
Sbjct: 3624 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3683

Query: 1461 LDLLEPLGRRKKQLESSRAKLQISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLF 1516
            +++ E    R + L+ +    +I  + E E + W   V ++L      DY T     Q  
Sbjct: 3684 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ-- 3741

Query: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEID-CQDLEERLGHLQSSWDRLREAAAG 1575
              + + LQ +IL     V+  L  G +L++    D    ++++L  +++ +  + + +  
Sbjct: 3742 QSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3801

Query: 1576 RLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISDE--IPKDEEGAIVM-----LKRHL 1627
              + L  A + A++ +   +E   W+ + E+ ++S E  + K EE +        LK+  
Sbjct: 3802 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3861

Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
            +  +A+ D   ++ +++S    L+     EG  + ++  + ++ Y  + D   ++  +++
Sbjct: 3862 KNNKALLD---SLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEID 3916

Query: 1688 NMYHLFQLKRETDDLE-QWISEKE-LVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQE 1745
                  Q   +  D E  WI+E E  + S  ++  + D  +      + F  E       
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME------- 3969

Query: 1746 RVDNVNAFIERLIDAGHS-EAATIAEWKDGLNEMWADLLELIDT--------RMQLLAAS 1796
             +      I+ L+ +GH    A   E K  + +    +L+  DT         +QL  A 
Sbjct: 3970 -ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 4028

Query: 1797 YDLHRYFYTGAEILGLIDEKH---RELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
              +++++ T  E+   + E      +LP    L+  T       H      +      + 
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAP-ALEYETLRQQQEEHRQLRELIAEHKPHID 4087

Query: 1854 QFQDVATRLQTAYAGE---------KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD 1904
            +      +L     GE          A+ + ++ +E        LD    + TQ  D  D
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4147

Query: 1905 KFRFFSMARDLLSWMESIIRQIETQERPRDVSS----VELLMKYHQGINAEIETRSKNFS 1960
            +             +ES+ R +E   +P  +S+    ++  +  ++ ++ ++E     + 
Sbjct: 4148 QI------------LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYE 4195

Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
               + GE ++ R     ++I  K  Q      +  ++    WE +  L+E     R+A +
Sbjct: 4196 TLKQRGEEMIARSGGTDKDISAKAVQ------DKLDQMVFIWENIHTLVE----EREAKL 4245

Query: 2021 AEAWLIAQE 2029
             +   +A++
Sbjct: 4246 LDVMELAEK 4254



 Score = 94.7 bits (234), Expect = 8e-19
 Identities = 157/754 (20%), Positives = 293/754 (38%), Gaps = 78/754 (10%)

Query: 307  YSGLASDLLTWIEQTIT-VLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
            + G   DL  W+  T   +L S+         ++QL        +E    F+ K      
Sbjct: 4583 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH-----MEVCAAFEAKEETYKS 4637

Query: 366  LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLAR 425
            L     +M A   K    +  + ++++   WES+E     R+  L   L        LA 
Sbjct: 4638 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL-------NLAM 4690

Query: 426  RFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDL 484
             F         WL++  Q L         L  V     +H+    +  ++ E++  L+  
Sbjct: 4691 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4750

Query: 485  AQELEKENYHDQKRITARKDNIL----RLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
               L+   Y  QK+      N+L      W  + + L  R + L+      K F +    
Sbjct: 4751 GTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4807

Query: 541  I-DWMDEIKAHLLSA-EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGK 598
            + +W++E +  L S  E      +++  L +HK  +  +  +   V   T  T +  + K
Sbjct: 4808 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK-HSVYDTTNRTGRSLKEK 4866

Query: 599  GYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAE-SWIKEKE 657
                 D   + D +S L   ++ +   +  R+ +LE++      F +  +A   W+   E
Sbjct: 4867 TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4926

Query: 658  -QIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEA 716
             Q+        D+  V+ L   HKAF+ EL    + ++ + + A  ++   +     ++ 
Sbjct: 4927 PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV 4986

Query: 717  RIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHRLLSGEDV-GQD 774
            +++E+S +W+ +  L+   +  L+ A     +F      L  WL +A + L    V   D
Sbjct: 4987 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 5046

Query: 775  EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD----VTHRLQALRELY 830
            E A R L  +HK+F+++LEE R  +   +    G        PD    + H +  +R  +
Sbjct: 5047 EDALRTLIDQHKEFMKKLEEKRAELN--KATTMGDTVLAICHPDSITTIKHWITIIRARF 5104

Query: 831  QQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME---MPDTLEDLEVV 886
            ++V+A A   QQRL  AL       E  +A   W+   E  L + +   +P  +E+++ +
Sbjct: 5105 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5164

Query: 887  QHRFDILDQEMKTLMTQIDGVN-----------------------------LAANSLVES 917
                    +EM      +D V                                A+SL  S
Sbjct: 5165 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5224

Query: 918  GHPRSREVKQYQDHLN-TRWQAFQTLVSERREAVDSAL-------RVHNYCVDC--EETS 967
            G     E K  + +L  ++WQ    L  ERR  ++ AL          N+  D   ++  
Sbjct: 5225 GSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYM 5284

Query: 968  KWIT-DKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
            +W+   K++V++  + + +D  G I  Q  + G+
Sbjct: 5285 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5318



 Score = 62.8 bits (151), Expect = 4e-09
 Identities = 59/292 (20%), Positives = 127/292 (43%), Gaps = 27/292 (9%)

Query: 515  ELLQSRRQRLETTLALQKLFQDMLHS------IDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
            +L+Q R+  L+++L  Q L ++ ++       ++W+DE++  L   E+G  L  VE  L+
Sbjct: 758  KLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE 817

Query: 569  KHK-----LMEADIAIQGDKVKAIT-AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEEL 622
             HK     + E + +++  K+  I   A LK T              +++  LE  + +L
Sbjct: 818  NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA------------EKLHRLESQYAKL 865

Query: 623  SNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF 682
             N +  ++  L+    L  F         W+ EKE+   + D+ +  T++   +  H   
Sbjct: 866  LNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL 922

Query: 683  EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
              EL   + +++ + + A  ++         IEA    +  QW  +  L    ++++++ 
Sbjct: 923  MRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN 982

Query: 743  ENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEE 794
              +F+F  DA +   +L++    +  +       +   L    ++ +EE EE
Sbjct: 983  TAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 1034



 Score = 59.7 bits (143), Expect = 3e-08
 Identities = 68/313 (21%), Positives = 135/313 (43%), Gaps = 39/313 (12%)

Query: 293  VIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEK 352
            ++D  +  E++  K+     DLL W+++    L+  ++ + L  V+  L+    ++ V +
Sbjct: 771  LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE---NHKNVHR 824

Query: 353  PPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRN 412
              +  E    E  +  IQ  M A  +  Y     +L            E++Y +   L N
Sbjct: 825  AIEEFESSLKEAKISEIQ--MTAPLKLTYAEKLHRL------------ESQYAK---LLN 867

Query: 413  ELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA--VEAAKKK--HEAIE 468
                QE+       F  +A     WL+E +    ++   YD +      A+KK  H  + 
Sbjct: 868  TSRNQERHLDTLHNFVSRATNELIWLNEKE----EEEVAYDWSERNTNIARKKDYHAELM 923

Query: 469  TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
             +    EE +++++++A++L  EN+  +  I A +  +   WS++ +L Q   Q ++   
Sbjct: 924  RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 983

Query: 529  ALQKLFQDMLHSIDWMDEIKAHL---LSAEFGKHLLEVEDLLQ-----KHKLMEADIAIQ 580
            A  + F D   + D++  +K  +    S +    + ++EDL+Q     K +L++    I 
Sbjct: 984  AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 1043

Query: 581  GDKVKAITAATLK 593
                KA T   LK
Sbjct: 1044 NLMGKAKTIIQLK 1056



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 48/248 (19%), Positives = 103/248 (41%), Gaps = 11/248 (4%)

Query: 1599 WIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL-ASRAQGLLSAGHPE 1657
            W+ E ++ +   E   D       L+ H    RA+E++  ++K+   S  Q         
Sbjct: 792  WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTY 851

Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
             E++ RL+ Q    YA L + +  ++R L+ +++   + R T++L  W++EKE    + +
Sbjct: 852  AEKLHRLESQ----YAKLLNTSRNQERHLDTLHNF--VSRATNEL-IWLNEKEEEEVAYD 904

Query: 1718 MGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNE 1777
              +   ++   +D   +  RE     +E + +V    E+L+   H    TI  ++  +  
Sbjct: 905  WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 963

Query: 1778 MWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRV 1837
             W+ +L+L     Q +  +     +F    E    +      +      D S+  S H++
Sbjct: 964  QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS--SIHKL 1021

Query: 1838 HTAFEREL 1845
                +  +
Sbjct: 1022 EDLVQESM 1029



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 147/816 (18%), Positives = 311/816 (38%), Gaps = 106/816 (12%)

Query: 1249 VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNL 1308
            +Q +E   RK  E   E S  L   L  Q  L +  E+      K+   Q  +   +  +
Sbjct: 1484 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATV 1540

Query: 1309 HNKWLKHQAFVAELASHEG-------WLENIDAEGKQLMDEKPQFTALVSQKLE------ 1355
             +  L+   + A + S +           + D   ++ MD + ++TALV+   +      
Sbjct: 1541 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1600

Query: 1356 -ALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLR-SDDPGKDLTS 1413
             +L RL +E ++  +EK +H+  A+          +L KW+S +   L+ ++  GK   S
Sbjct: 1601 DSLKRLEEEEKSLEEEKKEHVEKAK----------ELQKWVSNISKTLKDAEKAGKPPFS 1650

Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
                  K K   ++++ +KE+L E    +     + GD     E+  L+      +    
Sbjct: 1651 ------KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1704

Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH--- 1530
            L  S +  Q+        + VEE++   +  +Y   LQ +   + +    +N ++GH   
Sbjct: 1705 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQT---ENRLIGHQEA 1761

Query: 1531 ------TPRVEDVLQRGQQLVEAAEIDCQDLEERL----GHLQSSWDRL-REAAAGRLQR 1579
                  T  ++    + ++L +  +   Q L E +      L+ + ++L +E  A   Q+
Sbjct: 1762 FMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQK 1821

Query: 1580 LRDAN-EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR 1638
            L +A  + +Q  L A++++  + +     I +E  K    A+  L+    +   + D+  
Sbjct: 1822 LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK--VAAVKQLEESKTKIENLLDWLS 1879

Query: 1639 NIKQLASRA---------QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
            N+ + + RA         Q        +G+  I  + +V+ +     DV  +     EN+
Sbjct: 1880 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-TDVDGQVGTTQENL 1938

Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
               +Q  +     E+ IS+ + V  + +  Q      LL  + +  + E     Q+ +  
Sbjct: 1939 NQQYQKVKAQH--EKIISQHQAVIIATQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKE 1991

Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
            +    E  +     +       ++ L +  AD  E       L  +  +L        +I
Sbjct: 1992 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF---EHWLQQSEQELENLEAGADDI 2048

Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869
             GL+ +  R+            +SF     + + +L  + +   +  + A        G+
Sbjct: 2049 NGLMTKLKRQ------------KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096

Query: 1870 -----KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR-DLLSWMESII 1923
                     +Q K    +  +++L   C      L D  DK++ +  A   LL+ +++  
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156

Query: 1924 R----------QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
                        ++ +   R +   + L          +E   K     L+   SLL   
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL--- 2213

Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLL 2009
              A  +I++ L  ++ R +++++    R E+L++ L
Sbjct: 2214 -PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2248



 Score = 50.4 bits (119), Expect = 2e-05
 Identities = 136/759 (17%), Positives = 292/759 (38%), Gaps = 123/759 (16%)

Query: 964  EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
            ++   W+ D+ +V     + G DL  + +       + R +   ++ +   E +  ++  
Sbjct: 787  QDLLNWV-DEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK--EAKISEIQM 843

Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
            + P  K    ++   LE  +  L  + + QE  L     L  F+    +   WL+  ++ 
Sbjct: 844  TAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEE 899

Query: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
              + D  E      +    HA +  E+D  +++ + V+E  E+++  +  P  L +    
Sbjct: 900  EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL-ENHPARLTIEAYR 958

Query: 1144 EGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAA 1203
              + T W+ + ++ +     + +   + EF  DAK+A   L N +  +      D     
Sbjct: 959  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCD----R 1014

Query: 1204 EAGIRKFEDFLGSMENNRDKVLS-------------------------PVDSGNKLVA-- 1236
             + I K ED +      ++++L                          P+ +   + A  
Sbjct: 1015 SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAIC 1074

Query: 1237 -----EGNLYSDKIKEKVQLIEDRHR-------KNNEKAQEASVLL------RDNLELQN 1278
                 E  +Y D   ++  L  + HR           +A   SV        ++ ++L N
Sbjct: 1075 DYRQIEITIYKD---DECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN 1131

Query: 1279 FLQNCQE--LTLW----INDKLLTSQDVSYDEARNLHNKWL---------KHQAFVAELA 1323
             ++   +  LTLW    IN K + S     +E   +    +         +HQ  ++ L 
Sbjct: 1132 RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQ 1191

Query: 1324 SH-EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ-------HL 1375
            S  E +LE  D++  Q+          + +++    + + EL  + + + Q       ++
Sbjct: 1192 SRFEDFLE--DSQESQVFSGSD--ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI 1247

Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKD---LTSVNRMLAKLKRVEDQVNVRK 1432
            S  R+  LRL+   D  + I  +   L  DD  +    +T   ++  +L+R++D +    
Sbjct: 1248 SEVRNIRLRLENCED--RLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 1305

Query: 1433 EELGELFAQ------VPSMGEE------GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480
             +  E F+Q      VP++  E        +   S+   ++D L+ +    K  +++ A 
Sbjct: 1306 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1365

Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
            +++      ET   EE   +A       N++ +   +K+ ++  +E       +ED LQ+
Sbjct: 1366 VKLY-----ETKLCEEEAVIADK----NNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1416

Query: 1541 GQQL-------VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
             + +        +  ++D    +E+   L   W  +      RL+ L    ++ +YY D 
Sbjct: 1417 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1476

Query: 1594 -DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQR 1631
                + WI  Q++     +I +++      L   L QQ+
Sbjct: 1477 YHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQK 1513



 Score = 35.4 bits (80), Expect = 0.60
 Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 9/224 (4%)

Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV-----EDQVNVRKEELG 1436
            ++ ++   DL  W+  M+ QL   + G DL SV   L   K V     E + ++++ ++ 
Sbjct: 780  EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 839

Query: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEE 1496
            E+    P +     +    +E ++  LL     +++ L++      +SR   +E +W+ E
Sbjct: 840  EIQMTAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN--FVSR-ATNELIWLNE 895

Query: 1497 RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLE 1556
            +     + D+      +      +  L  E+      ++ V +  +QL+         +E
Sbjct: 896  KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 955

Query: 1557 ERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
                 +Q+ W  + +      Q +++     +++ DA EA  ++
Sbjct: 956  AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 999



 Score = 33.9 bits (76), Expect = 1.8
 Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 32/212 (15%)

Query: 1808 EILGLIDEKHRELPE-----DVGLDASTAESFHRVHTAFER-ELHLLGVQVQQFQDVATR 1861
            ++L  +DE   +L       D+    S  E+   VH A E  E  L   ++ + Q  A  
Sbjct: 788  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP- 846

Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
            L+  YA         K   + + +  LL+    +   L DT   F   S A + L W+  
Sbjct: 847  LKLTYA--------EKLHRLESQYAKLLNTSRNQERHL-DTLHNF--VSRATNELIWLNE 895

Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
               +    +     +++     YH  +  E++ + +N  +  E+ E LL   H A   I 
Sbjct: 896  KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 955

Query: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
                   + R  M  +W   W     +L++CQ
Sbjct: 956  -------AYRAAMQTQWS--W-----ILQLCQ 973



 Score = 32.0 bits (71), Expect = 6.7
 Identities = 47/286 (16%), Positives = 105/286 (36%), Gaps = 20/286 (6%)

Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
            DL  W+ E ++     E G D   V    +  ++  R            +  F   L +A
Sbjct: 788  DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA-----------IEEFESSLKEA 836

Query: 1761 GHSEAATIAEWK----DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGA-EILGLIDE 1815
              SE    A  K    + L+ + +   +L++T          LH +      E++ L ++
Sbjct: 837  KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 896

Query: 1816 KHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQ 1875
            +  E+  D     +        H    REL      ++  Q++A +L       +   I+
Sbjct: 897  EEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL-TIE 955

Query: 1876 NKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQ---ERP 1932
                 +   W  +L  C      + +    F FF+ A++   ++ ++   I+ +   +R 
Sbjct: 956  AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS 1015

Query: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASE 1978
              +  +E L++       E+       +  +   ++++Q + + S+
Sbjct: 1016 SSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 1061


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.131    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,065,171
Number of Sequences: 37866
Number of extensions: 3397505
Number of successful extensions: 21658
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 133
Number of HSP's successfully gapped in prelim test: 547
Number of HSP's that attempted gapping in prelim test: 13476
Number of HSP's gapped (non-prelim): 4215
length of query: 2137
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2019
effective length of database: 13,779,330
effective search space: 27820467270
effective search space used: 27820467270
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press