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Search of human proteins with 67782319
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|67782319 spectrin beta isoform b [Homo sapiens]
(2137 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|67782319 spectrin beta isoform b [Homo sapiens] 4239 0.0
gi|67782321 spectrin beta isoform a [Homo sapiens] 4192 0.0
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 2648 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 2597 0.0
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 2303 0.0
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 1966 0.0
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 869 0.0
gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [... 577 e-164
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 574 e-163
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 568 e-161
gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens] 513 e-145
gi|12025678 actinin, alpha 4 [Homo sapiens] 439 e-122
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 431 e-120
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 431 e-120
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 431 e-120
gi|4501893 actinin, alpha 2 [Homo sapiens] 416 e-115
gi|4557241 actinin, alpha 3 [Homo sapiens] 409 e-113
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 376 e-103
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 375 e-103
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 374 e-103
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 373 e-103
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 372 e-102
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 372 e-102
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 372 e-102
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 372 e-102
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 337 6e-92
gi|33188445 microfilament and actin filament cross-linker protei... 298 3e-80
gi|221316624 dystonin isoform 4 [Homo sapiens] 298 4e-80
gi|221316622 dystonin isoform 3 [Homo sapiens] 298 4e-80
gi|221316618 dystonin isoform 2 [Homo sapiens] 298 4e-80
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 4239 bits (10993), Expect = 0.0
Identities = 2137/2137 (100%), Positives = 2137/2137 (100%)
Query: 1 MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60
MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF
Sbjct: 1 MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60
Query: 61 TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120
TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL
Sbjct: 61 TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120
Query: 121 QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180
QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL
Sbjct: 121 QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180
Query: 181 LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240
LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV
Sbjct: 181 LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240
Query: 241 AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300
AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET
Sbjct: 241 AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300
Query: 301 EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360
EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG
Sbjct: 301 EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360
Query: 361 NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420
NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL
Sbjct: 361 NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420
Query: 421 EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480
EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA
Sbjct: 421 EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480
Query: 481 LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS
Sbjct: 481 LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
Query: 541 IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY
Sbjct: 541 IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
Query: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY
Sbjct: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
Query: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE
Sbjct: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
Query: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA
Sbjct: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
Query: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR
Sbjct: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
Query: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL
Sbjct: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
Query: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC
Sbjct: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
Query: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ
Sbjct: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
Query: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT
Sbjct: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
Query: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA
Sbjct: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500
QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500
Query: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG
Sbjct: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620
HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620
Query: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE
Sbjct: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
Query: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG
Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
Query: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH
Sbjct: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
Query: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT
Sbjct: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
Query: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME
Sbjct: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980
SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI
Sbjct: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980
Query: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040
REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT
Sbjct: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040
Query: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100
VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG
Sbjct: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100
Query: 2101 EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY 2137
EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY
Sbjct: 2101 EAPVSHHAATERTSPVSLWSRLSSSWESLQPEPSHPY 2137
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 4192 bits (10871), Expect = 0.0
Identities = 2115/2115 (100%), Positives = 2115/2115 (100%)
Query: 1 MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60
MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF
Sbjct: 1 MTSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTF 60
Query: 61 TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120
TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL
Sbjct: 61 TKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKAL 120
Query: 121 QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180
QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL
Sbjct: 121 QFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALL 180
Query: 181 LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240
LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV
Sbjct: 181 LWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNV 240
Query: 241 AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300
AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET
Sbjct: 241 AERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIET 300
Query: 301 EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360
EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG
Sbjct: 301 EKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG 360
Query: 361 NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420
NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL
Sbjct: 361 NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKL 420
Query: 421 EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480
EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA
Sbjct: 421 EQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRA 480
Query: 481 LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS
Sbjct: 481 LEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
Query: 541 IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY
Sbjct: 541 IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
Query: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY
Sbjct: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
Query: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE
Sbjct: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
Query: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA
Sbjct: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
Query: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR
Sbjct: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
Query: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL
Sbjct: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
Query: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC
Sbjct: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
Query: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ
Sbjct: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
Query: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT
Sbjct: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL
Sbjct: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN
Sbjct: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
Query: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA
Sbjct: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS
Sbjct: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA
Sbjct: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500
QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL
Sbjct: 1441 QVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPL 1500
Query: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG
Sbjct: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620
HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI
Sbjct: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAI 1620
Query: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE
Sbjct: 1621 VMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
Query: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG
Sbjct: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
Query: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH
Sbjct: 1741 AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
Query: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT
Sbjct: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
Query: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME
Sbjct: 1861 RLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980
SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI
Sbjct: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEI 1980
Query: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040
REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT
Sbjct: 1981 REKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHT 2040
Query: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100
VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG
Sbjct: 2041 VDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAG 2100
Query: 2101 EAPVSHHAATERTSP 2115
EAPVSHHAATERTSP
Sbjct: 2101 EAPVSHHAATERTSP 2115
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 2648 bits (6864), Expect = 0.0
Identities = 1293/2110 (61%), Positives = 1655/2110 (78%), Gaps = 12/2110 (0%)
Query: 2 TSATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFT 61
T AT+++N+ Q YS +N RWD D+ DN+NSSARLFERSRIKALADERE VQKKTFT
Sbjct: 4 TVATDYDNIEIQQQYSDVNNRWDV--DDWDNENSSARLFERSRIKALADEREAVQKKTFT 61
Query: 62 KWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQ 121
KWVNSHLARVSCRITDLY DLRDGRMLIKLLEVLSGE LPKPTKG+MRIHCLENVDKALQ
Sbjct: 62 KWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHCLENVDKALQ 121
Query: 122 FLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLL 181
FLKEQRVHLENMGSHDIVDGNHRL LGLIWTIILRFQIQDI V+T++ +E +SAKDALLL
Sbjct: 122 FLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEKKSAKDALLL 181
Query: 182 WCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVA 241
WCQMKTAGYP+VN+ NFT+SW+DG+AFNALIHKHRPDLIDFDKLK SNA +NL++AFN+A
Sbjct: 182 WCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLA 241
Query: 242 ERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETE 301
E+ LG+ LLDPED+ ++PDEKSIITYVV +YHYFSKMK LAVEGKR+GKV+D+AIETE
Sbjct: 242 EQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIGKVLDNAIETE 301
Query: 302 KMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGN 361
KMIEKY LASDLL WIEQTI +LN+RKFANSL GVQQQLQAF+TYRTVEKPPKF EKGN
Sbjct: 302 KMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVEKPPKFTEKGN 361
Query: 362 LEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLE 421
LEVLLFTIQS+MRANNQKVY P +GKL+SDIN+AWE LE+AE+ RELALRNELIRQEKLE
Sbjct: 362 LEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALRNELIRQEKLE 421
Query: 422 QLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRAL 481
QLARRFDRKAAMRETWLSENQRLV+QDNFG+DL AVEAA KKHEAIETD AAYEERV+A+
Sbjct: 422 QLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIETDIAAYEERVQAV 481
Query: 482 EDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI 541
+A+ELE ENYHD KRITARKDN++RLW YL ELL++RRQRLE L LQK+FQ+ML+ +
Sbjct: 482 VAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIM 541
Query: 542 DWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGY 600
DWMDE+K +LS ++GKHLL VEDLLQKH L+EADI IQ ++V+ + A+ KF T+G+GY
Sbjct: 542 DWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGY 601
Query: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
+PCDPQVI+DR++H+E C++EL +AA R+A+LE+S+RLWKFFWEM E E WI+EKE+I
Sbjct: 602 KPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKIL 661
Query: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKE 720
SS DYGKDLTSV+ L KH+AFEDE+ G H EQ +E M+A + FG +I RI
Sbjct: 662 SSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIY 721
Query: 721 VSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRA 780
+ QW L+ L+A KK L++A QFQ DADD+ AW+ D +++S DVG DE +T++
Sbjct: 722 IREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQS 781
Query: 781 LGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLR 840
L KKHKD EE+ R ++ L +QA P+E +SPDV RL + E Y++V LR
Sbjct: 782 LVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLR 841
Query: 841 QQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL 900
+Q LQ+ L LY +F E DACELW+ EKE+WL M++P+ LEDLEV+QHRF+ L+ EM
Sbjct: 842 KQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQ 901
Query: 901 MTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYC 960
+++ VN A L+ SGHP +E+K QD LNTRW F+ LV +++A+ SAL + NY
Sbjct: 902 ASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYH 961
Query: 961 VDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQ 1020
++C ET WI +KTKV+EST+DLG DLAG++A+QRKL+G+ERD+ AI+A++ L++E+++
Sbjct: 962 LECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEK 1021
Query: 1021 LMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
L HP+Q + I R + ++W+ ++ +L+ +E LGE S+LQ FL+DLDDFQ+WLS T
Sbjct: 1022 LESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRT 1081
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
Q A+ASEDMP +L EAE+LL QH IK+EID +++ YQ++++ GE V QGQTD +Y+ L
Sbjct: 1082 QTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLR 1141
Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
QRL+ LDTGWN L +MWE+R + L+Q +Q+F +D KQAEA L+NQEY LAH E P +L
Sbjct: 1142 QRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTL 1201
Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNN 1260
E AEA I+K EDF+ +M+ N +K+ + V++G +LV++GN+ SD+I+EKV I+DRHRKN
Sbjct: 1202 EGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNR 1261
Query: 1261 EKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVA 1320
E A E + L+DN +LQ FLQ+CQEL+LWIN+K+LT+QD+SYDEARNLH+KWLKHQAF+A
Sbjct: 1262 ETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMA 1321
Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
ELAS++ WL+ I+ EG QL+ EKP+ A+V +KL LH++W+ L++TT+ K Q L A
Sbjct: 1322 ELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANK 1381
Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
++L Q+ ADL+KW+ +E Q++SDD GKDLTSVN +L K + +E+Q+ VRK+E+ EL +
Sbjct: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQS 1441
Query: 1441 QVPSMGEEGGDAD------LSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWV 1494
Q ++ +EG D L+++ +F++LLEPL RK L +S+ Q +RD+EDE LWV
Sbjct: 1442 QAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWV 1501
Query: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLV-EAAEIDCQ 1553
ER+PLA S D+G NLQTVQL +KKNQTLQ EI GH PR++D+ +R Q +V +++ + +
Sbjct: 1502 GERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAE 1561
Query: 1554 DLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIP 1613
+ +RL L+ W L E R +RL +A+ AQQYY DA EAEAW+ EQELY++S+E
Sbjct: 1562 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA 1621
Query: 1614 KDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYA 1673
KDE+ A+ MLK+H ++AVEDY + QL+ ++ L++ HPE E+I Q +VDK YA
Sbjct: 1622 KDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYA 1681
Query: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
GLKD+AEER+ KL+ + LFQL RE DDLEQWI+E+E+VA S E+GQD++HVT+L+++FR
Sbjct: 1682 GLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFR 1741
Query: 1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
+FAR+TG IGQERVD VN + LI++GHS+AATIAEWKDGLNE WADLLELIDTR Q+L
Sbjct: 1742 EFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQIL 1801
Query: 1794 AASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
AASY+LH++++ EI G I +KH++LPE++G D +T E+ R+HT FE ++ LG QV+
Sbjct: 1802 AASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQVR 1861
Query: 1854 QFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913
Q Q+ A RLQ AYAG+KA+ IQ +E EV AW++LLDAC RR +LVDT DKFRFFSM R
Sbjct: 1862 QLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMVR 1921
Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
DL+ WME +IRQIE QE+PRDVSSVELLM HQGI AEI+ R+ +F+ C+ELG+SLL R+
Sbjct: 1922 DLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARK 1981
Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLA 2033
H ASEEI+EKL Q+ +RKEM +KWE RWE LR++LEV QFSRDASVAEAWL+ QEPYL+
Sbjct: 1982 HYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYLS 2041
Query: 2034 SGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKE--RQIAERPAEETGP 2091
S + G +VD VEKLIKRHEAFEKS A+W ERF+ALE+ TTLEL E RQ E + P
Sbjct: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPP 2101
Query: 2092 QEEEGETAGE 2101
E E
Sbjct: 2102 SPEPSTKVSE 2111
Score = 259 bits (663), Expect = 2e-68
Identities = 277/1456 (19%), Positives = 605/1456 (41%), Gaps = 79/1456 (5%)
Query: 298 IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
+E ++ ++ A D+ W+ + +++S + +ST V+K
Sbjct: 740 LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD---------EYSTQSLVKKHKDVA 790
Query: 358 EK-GNLEVLLFTIQSRMRANNQK-VYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
E+ N L T+ + A Q+ +P +S I ++ + E R+ AL++ L
Sbjct: 791 EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 850
Query: 416 RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
L + F A E W+ E ++ + L +E + + E++E +
Sbjct: 851 -------LYKMFSEADAC-ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA 902
Query: 476 ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
RV + +A++L + +K I A++D + WS +EL+ ++ L + L++Q
Sbjct: 903 SRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHL 962
Query: 536 DMLHSIDWMDE-IKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
+ + W+ E K + + G L V L +K ME D+ K+ + K
Sbjct: 963 ECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1022
Query: 595 TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIK 654
+ P Q I R++ + +EE+ R+A L ++ +L +F ++D+ +SW+
Sbjct: 1023 ---ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1079
Query: 655 EKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFG--HP 712
+ +S D LT L +H+ ++E+ + +++ ++ MV + Q +
Sbjct: 1080 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYM 1138
Query: 713 QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
+ R++ + W++L + + L + + QF D +A+L + +L+ ++
Sbjct: 1139 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1198
Query: 773 QD-EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELY 830
EGA A+ KK +DF+ ++ + + + + + + + D + ++ ++ + +
Sbjct: 1199 TTLEGAEAAI-KKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRH 1257
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
++ A RL++ DL + LW+ EK +M D +L +
Sbjct: 1258 RKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEARNLHSKWLKH 1316
Query: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
E+ + +D + L+ VK+ L+ W+ ++ + + +
Sbjct: 1317 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1376
Query: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
A + + C + KW+ ++S D G+DL + + +K LE + +
Sbjct: 1377 FDANKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNILLKKQQMLENQMEVRKKE 1435
Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
++ L+ ++Q L + +++ ++ ++ + L + L ++ L ++ F +D+
Sbjct: 1436 IEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV 1494
Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
+D W+ S D +L + L++++ ++ EI GHQ + E + ++
Sbjct: 1495 EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTD 1554
Query: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYT 1190
+ + QRL L W L E R L + Q++ DA +AEA +S QE
Sbjct: 1555 SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELY 1614
Query: 1191 LAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
+ E ++A + ++K + ++E+ + V + LVA+ + S++I +
Sbjct: 1615 MMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQS 1674
Query: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQD----VSYDEAR 1306
++ + + A+E L + L + +L WI ++ + + Y+
Sbjct: 1675 KVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVT 1734
Query: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
L ++ + + ++ ++ +L++ A +++ + L+ W +L
Sbjct: 1735 MLQERFREFARDTGNIGQER--VDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1792
Query: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRS--DDPGKDLTSVNRMLAKLKRV 1424
+TQ L+A S +L H D + ++D+ + ++ G+D +V +
Sbjct: 1793 LIDTRTQILAA--SYELHKFYH-DAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1849
Query: 1425 EDQVNVRKEELGELFAQVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQI 1483
E + ++ +L + GD I+KR ++LE ES R +L
Sbjct: 1850 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1909
Query: 1484 SRD-------LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
+ D + D LW+E+ + ++ + ++ +V+L M +Q ++ EI
Sbjct: 1910 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1969
Query: 1537 VLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEA 1596
++ G+ L+ ++++E+L L + + R + LR E Q+ DA A
Sbjct: 1970 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2029
Query: 1597 EAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHP 1656
EAW+ QE Y+ S EI + + ++KRH +++ + L R L
Sbjct: 2030 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL------ 2082
Query: 1657 EGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQW-------ISEK 1709
+++ ++ Q ++ EERKR+ + ++ E + +QW +S+
Sbjct: 2083 ---ELLEVRRQQEE---------EERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQN 2130
Query: 1710 ELVA--SSPEMGQDFD 1723
L A SP M + D
Sbjct: 2131 GLPAEQGSPRMAETVD 2146
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 2597 bits (6732), Expect = 0.0
Identities = 1266/2068 (61%), Positives = 1621/2068 (78%), Gaps = 10/2068 (0%)
Query: 44 RIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKP 103
R K L DERE VQKKTFTKWVNSHLARVSCRITDLY DLRDGRMLIKLLEVLSGE LPKP
Sbjct: 31 RFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKP 90
Query: 104 TKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIV 163
TKG+MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRL LGLIWTIILRFQIQDI
Sbjct: 91 TKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDIS 150
Query: 164 VQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFD 223
V+T++ +E +SAKDALLLWCQMKTAGYP+VN+ NFT+SW+DG+AFNALIHKHRPDLIDFD
Sbjct: 151 VETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFD 210
Query: 224 KLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVL 283
KLK SNA +NL++AFN+AE+ LG+ LLDPED+ ++PDEKSIITYVV +YHYFSKMK L
Sbjct: 211 KLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKAL 270
Query: 284 AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
AVEGKR+GKV+D+AIETEKMIEKY LASDLL WIEQTI +LN+RKFANSL GVQQQLQA
Sbjct: 271 AVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQA 330
Query: 344 FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
F+TYRTVEKPPKF EKGNLEVLLFTIQS+MRANNQKVY P +GKL+SDIN+AWE LE+AE
Sbjct: 331 FNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAE 390
Query: 404 YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKK 463
+ RELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLV+QDNFG+DL AVEAA KK
Sbjct: 391 HERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKK 450
Query: 464 HEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQR 523
HEAIETD AAYEERV+A+ +A+ELE ENYHD KRITARKDN++RLW YL ELL++RRQR
Sbjct: 451 HEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQR 510
Query: 524 LETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDK 583
LE L LQK+FQ+ML+ +DWMDE+K +LS ++GKHLL VEDLLQKH L+EADI IQ ++
Sbjct: 511 LEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKHTLVEADIGIQAER 570
Query: 584 VKAITAATLKF-TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKF 642
V+ + A+ KF T+G+GY+PCDPQVI+DR++H+E C++EL +AA R+A+LE+S+RLWKF
Sbjct: 571 VRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRARLEESRRLWKF 630
Query: 643 FWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHG 702
FWEM E E WI+EKE+I SS DYGKDLTSV+ L KH+AFEDE+ G H EQ +E
Sbjct: 631 FWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGED 690
Query: 703 MVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDA 762
M+A + FG +I RI + QW L+ L+A KK L++A QFQ DADD+ AW+ D
Sbjct: 691 MIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAWMLDI 750
Query: 763 HRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHR 822
+++S DVG DE +T++L KKHKD EE+ R ++ L +QA P+E +SPDV R
Sbjct: 751 LKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPDVRGR 810
Query: 823 LQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLED 882
L + E Y++V LR+Q LQ+ L LY +F E DACELW+ EKE+WL M++P+ LED
Sbjct: 811 LSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 870
Query: 883 LEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942
LEV+QHRF+ L+ EM +++ VN A L+ SGHP +E+K QD LNTRW F+ L
Sbjct: 871 LEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFREL 930
Query: 943 VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLER 1002
V +++A+ SAL + NY ++C ET WI +KTKV+EST+DLG DLAG++A+QRKL+G+ER
Sbjct: 931 VDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMER 990
Query: 1003 DVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ 1062
D+ AI+A++ L++E+++L HP+Q + I R + ++W+ ++ +L+ +E LGE S+
Sbjct: 991 DLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASK 1050
Query: 1063 LQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKE 1122
LQ FL+DLDDFQ+WLS TQ A+ASEDMP +L EAE+LL QH IK+EID +++ YQ++++
Sbjct: 1051 LQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRD 1110
Query: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
GE V QGQTD +Y+ L QRL+ LDTGWN L +MWE+R + L+Q +Q+F +D KQAEA
Sbjct: 1111 MGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEA 1170
Query: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
L+NQEY LAH E P +LE AEA I+K EDF+ +M+ N +K+ + V++G +LV++GN+ S
Sbjct: 1171 FLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINS 1230
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSY 1302
D+I+EKV I+DRHRKN E A E + L+DN +LQ FLQ+CQEL+LWIN+K+LT+QD+SY
Sbjct: 1231 DRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY 1290
Query: 1303 DEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWD 1362
DEARNLH+KWLKHQAF+AELAS++ WL+ I+ EG QL+ EKP+ A+V +KL LH++W+
Sbjct: 1291 DEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWE 1350
Query: 1363 ELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLK 1422
L++TT+ K Q L A ++L Q+ ADL+KW+ +E Q++SDD GKDLTSVN +L K +
Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410
Query: 1423 RVEDQVNVRKEELGELFAQVPSMGEEGGDAD------LSIEKRFLDLLEPLGRRKKQLES 1476
+E+Q+ VRK+E+ EL +Q ++ +EG D L+++ +F++LLEPL RK L +
Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLA 1470
Query: 1477 SRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
S+ Q +RD+EDE LWV ER+PLA S D+G NLQTVQL +KKNQTLQ EI GH PR++D
Sbjct: 1471 SKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDD 1530
Query: 1537 VLQRGQQLV-EAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
+ +R Q +V +++ + + + +RL L+ W L E R +RL +A+ AQQYY DA E
Sbjct: 1531 IFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAE 1590
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
AEAW+ EQELY++S+E KDE+ A+ MLK+H ++AVEDY + QL+ ++ L++ H
Sbjct: 1591 AEAWMSEQELYMMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSH 1650
Query: 1656 PEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASS 1715
PE E+I Q +VDK YAGLKD+AEER+ KL+ + LFQL RE DDLEQWI+E+E+VA S
Sbjct: 1651 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1710
Query: 1716 PEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775
E+GQD++HVT+L+++FR+FAR+TG IGQERVD VN + LI++GHS+AATIAEWKDGL
Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGL 1770
Query: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835
NE WADLLELIDTR Q+LAASY+LH++++ EI G I +KH++LPE++G D +T E+
Sbjct: 1771 NEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQ 1830
Query: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
R+HT FE ++ LG QV+Q Q+ A RLQ AYAG+KA+ IQ +E EV AW++LLDAC R
Sbjct: 1831 RMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESR 1890
Query: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
R +LVDT DKFRFFSM RDL+ WME +IRQIE QE+PRDVSSVELLM HQGI AEI+ R
Sbjct: 1891 RVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDAR 1950
Query: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
+ +F+ C+ELG+SLL R+H ASEEI+EKL Q+ +RKEM +KWE RWE LR++LEV QFS
Sbjct: 1951 NDSFTTCIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFS 2010
Query: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLE 2075
RDASVAEAWL+ QEPYL+S + G +VD VEKLIKRHEAFEKS A+W ERF+ALE+ TTLE
Sbjct: 2011 RDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLE 2070
Query: 2076 LKE--RQIAERPAEETGPQEEEGETAGE 2101
L E RQ E + P E E
Sbjct: 2071 LLEVRRQQEEEERKRRPPSPEPSTKVSE 2098
Score = 259 bits (662), Expect = 2e-68
Identities = 271/1433 (18%), Positives = 597/1433 (41%), Gaps = 70/1433 (4%)
Query: 298 IETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQ 357
+E ++ ++ A D+ W+ + +++S + +ST V+K
Sbjct: 727 LEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHD---------EYSTQSLVKKHKDVA 777
Query: 358 EK-GNLEVLLFTIQSRMRANNQK-VYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
E+ N L T+ + A Q+ +P +S I ++ + E R+ AL++ L
Sbjct: 778 EEIANYRPTLDTLHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA 837
Query: 416 RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
L + F A E W+ E ++ + L +E + + E++E +
Sbjct: 838 -------LYKMFSEADAC-ELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQA 889
Query: 476 ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
RV + +A++L + +K I A++D + WS +EL+ ++ L + L++Q
Sbjct: 890 SRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHL 949
Query: 536 DMLHSIDWMDE-IKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
+ + W+ E K + + G L V L +K ME D+ K+ + K
Sbjct: 950 ECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKL 1009
Query: 595 TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIK 654
+ P Q I R++ + +EE+ R+A L ++ +L +F ++D+ +SW+
Sbjct: 1010 ---ESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLS 1066
Query: 655 EKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFG--HP 712
+ +S D LT L +H+ ++E+ + +++ ++ MV + Q +
Sbjct: 1067 RTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKM-RDMGEMVTQGQTDAQYM 1125
Query: 713 QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
+ R++ + W++L + + L + + QF D +A+L + +L+ ++
Sbjct: 1126 FLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMP 1185
Query: 773 QD-EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELY 830
EGA A+ KK +DF+ ++ + + + + + + + D + ++ ++ + +
Sbjct: 1186 TTLEGAEAAI-KKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRH 1244
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
++ A RL++ DL + LW+ EK +M D +L +
Sbjct: 1245 RKNRETASELLMRLKDNRDLQKFLQDCQELSLWINEKMLTAQDMSY-DEARNLHSKWLKH 1303
Query: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
E+ + +D + L+ VK+ L+ W+ ++ + + +
Sbjct: 1304 QAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL 1363
Query: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
A + + C + KW+ ++S D G+DL + + +K LE + +
Sbjct: 1364 FDANKAELFTQSCADLDKWLHGLESQIQSD-DYGKDLTSVNILLKKQQMLENQMEVRKKE 1422
Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
++ L+ ++Q L + +++ ++ ++ + L + L ++ L ++ F +D+
Sbjct: 1423 IEELQSQAQAL-SQEGKSTDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDV 1481
Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
+D W+ S D +L + L++++ ++ EI GHQ + E + ++
Sbjct: 1482 EDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTD 1541
Query: 1131 QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYT 1190
+ + QRL L W L E R L + Q++ DA +AEA +S QE
Sbjct: 1542 SSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELY 1601
Query: 1191 LAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
+ E ++A + ++K + ++E+ + V + LVA+ + S++I +
Sbjct: 1602 MMSEEKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQS 1661
Query: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQD----VSYDEAR 1306
++ + + A+E L + L + +L WI ++ + + Y+
Sbjct: 1662 KVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVT 1721
Query: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
L ++ + + ++ ++ +L++ A +++ + L+ W +L
Sbjct: 1722 MLQERFREFARDTGNIGQER--VDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLE 1779
Query: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRS--DDPGKDLTSVNRMLAKLKRV 1424
+TQ L+A S +L H D + ++D+ + ++ G+D +V +
Sbjct: 1780 LIDTRTQILAA--SYELHKFYH-DAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTF 1836
Query: 1425 EDQVNVRKEELGELFAQVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQI 1483
E + ++ +L + GD I+KR ++LE ES R +L
Sbjct: 1837 EHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVD 1896
Query: 1484 SRD-------LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVED 1536
+ D + D LW+E+ + ++ + ++ +V+L M +Q ++ EI
Sbjct: 1897 TGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTT 1956
Query: 1537 VLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEA 1596
++ G+ L+ ++++E+L L + + R + LR E Q+ DA A
Sbjct: 1957 CIELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVA 2016
Query: 1597 EAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHP 1656
EAW+ QE Y+ S EI + + ++KRH +++ + L R L
Sbjct: 2017 EAWLLGQEPYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL-ERLTTL------ 2069
Query: 1657 EGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEK 1709
+++ ++ Q ++ EERKR+ + ++ E + +QW + K
Sbjct: 2070 ---ELLEVRRQQEE---------EERKRRPPSPEPSTKVSEEAESQQQWDTSK 2110
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 2303 bits (5969), Expect = 0.0
Identities = 1154/2139 (53%), Positives = 1535/2139 (71%), Gaps = 22/2139 (1%)
Query: 3 SATEFENVGNQPPYSRINARWDAPDDELDNDNSSARLFERSRIKALADEREVVQKKTFTK 62
S T+F+++ Q YS IN RWD PD + DND+SSARLFERSRIKALADERE VQKKTFTK
Sbjct: 6 SPTDFDSLEIQGQYSDINNRWDLPDSDWDNDSSSARLFERSRIKALADEREAVQKKTFTK 65
Query: 63 WVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQF 122
WVNSHLARV+CR+ DLY DLRDGR L++LLEVLSGE+LPKPTKG+MRIHCLENVDKALQF
Sbjct: 66 WVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQF 125
Query: 123 LKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLW 182
LKEQ+VHLENMGSHDIVDGNHRL LGL+WTIILRFQIQDI V+T++ +E +SAKDALLLW
Sbjct: 126 LKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLW 185
Query: 183 CQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAE 242
CQMKTAGYP+VNV NFT+SW+DGLAFNA++HKHRPDL+DF+ LK NA +NL++AFN+AE
Sbjct: 186 CQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAE 245
Query: 243 RQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEK 302
++LG+ LLDPEDV + PDEKSIITYV +YHYFSKMK LAVEGKR+GKV+DHA+E E+
Sbjct: 246 KELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAER 305
Query: 303 MIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNL 362
++EKY LAS+LL WIEQTI LN R+ ANSL+GVQ QLQ+F++YRTVEKPPKF EKGNL
Sbjct: 306 LVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNL 365
Query: 363 EVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQ 422
EVLLFTIQS++RANNQKVYTP +G+L+SDIN+AWE LE+AE+ RELALR ELIRQEKLEQ
Sbjct: 366 EVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQ 425
Query: 423 LARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
LA RFDRKAAMRETWLSENQRLV+QDNFG +LAAVEAA +KHEAIETD AY RV+A++
Sbjct: 426 LAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVD 485
Query: 483 DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
+A EL E YHD KRI AR+ N+ RLW +L++++ +RR+RL L LQK+FQD+L+ +D
Sbjct: 486 AVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMD 545
Query: 543 WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF-TEGKGYQ 601
WM+E+K L S + G+HL VEDLLQ H+L+EADIA+Q ++V+A++A+ L+F GK Y+
Sbjct: 546 WMEEMKGRLQSQDLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR 605
Query: 602 PCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
PCDPQ++ +R++ LEQ +E L +AA R+A+LE+S+RLW+F WE+ EAE+W++E++ + +
Sbjct: 606 PCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLA 665
Query: 662 SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
S D G+DLT L L KH A E+ G L+ ++ +VA G Q AR E+
Sbjct: 666 SADTGRDLTGALRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAEL 725
Query: 722 SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
AQW++L+ LA + L A + +QFQ DA+D++AWL DA RL+S ++G DE +T+AL
Sbjct: 726 QAQWERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQAL 785
Query: 782 GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
++H+ EE+ R ++ L +QA P +P+V R+ L Y+++ A+A R
Sbjct: 786 ARQHRALEEEIRSHRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERA 845
Query: 842 QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
+ L+ AL LYT+ E AC LW+ EKE+WL + +P+ LEDLEVVQ RF+ L+ EM TL
Sbjct: 846 RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLA 905
Query: 902 TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
QI VN A L+++ P + Q+ LN RWQ F+ L ++ A+ SAL + NY +
Sbjct: 906 AQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHL 965
Query: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
+C ET W+ +KTKV+EST+ LG DLAG++A+QRKL+G ERD+ AI ARV L RE+ L
Sbjct: 966 ECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANAL 1025
Query: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
HP Q I R + ++ W+ L+ +++ +E+ LGE +LQ FL+ LDDFQAWL TQ
Sbjct: 1026 AAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQ 1085
Query: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQ 1141
AVASE+ P +LPEAE LL QHA ++ E++ Q Y R++ GE+V + Q DP+ L L Q
Sbjct: 1086 TAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLRALGEEVTRDQADPQCLFLRQ 1145
Query: 1142 RLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLE 1201
RLE L TGW LGRMWESR LAQ GFQ F +DA+QAE +LS+QEY L+H E P +L+
Sbjct: 1146 RLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTLQ 1205
Query: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNE 1261
AA+A I+K EDF+ +M+ N +++ +++G +LV+EGN+++DKI+EK IE RH+KN +
Sbjct: 1206 AADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADSIERRHKKNQD 1265
Query: 1262 KAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAE 1321
AQ+ LRDN E Q+FLQ+C EL LWI++K+LT+QDVSYDEARNLH KW KHQAF+AE
Sbjct: 1266 AAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTKWQKHQAFMAE 1325
Query: 1322 LASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
LA+++ WL+ +D EG++L EKP+ ALVS+KL LHR WDEL+ TT+ K + L A +
Sbjct: 1326 LAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRA 1385
Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
+L Q+ L W+ +++ QL SDD GKDLTSVN +L K + +E ++ VR++E+ + AQ
Sbjct: 1386 ELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQ 1445
Query: 1442 VPSMGEEGGDA------DLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
++ +E A ++E++F L +P+ R ++L++SR + Q RD+EDE LWV
Sbjct: 1446 AKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVT 1505
Query: 1496 ERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDL 1555
ERLP+A S ++G +L +VQL MKKNQTLQ EI GH PR+ D+ +R + L AA
Sbjct: 1506 ERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAA------A 1559
Query: 1556 EERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKD 1615
L LQ W RL R +RL DA AQQ+Y DA EAEAW+GEQEL+++ E KD
Sbjct: 1560 GPELAELQEMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKD 1619
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E A +K+H ++A+ DY + I QLA+ +Q ++ HPE +I Q QVDK YAGL
Sbjct: 1620 ELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGL 1679
Query: 1676 KDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDF 1735
K++A ER+ +L+ L QL+RE DDLEQWI E+E+VA+S E+GQD++HVT+LRDKFR+F
Sbjct: 1680 KELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREF 1739
Query: 1736 ARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAA 1795
+R+T IGQERVD+ NA LI GH+ AT+AEWKD LNE WADLLEL+DTR Q+LAA
Sbjct: 1740 SRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAA 1799
Query: 1796 SYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQF 1855
+Y+L R+ + + L + K ++LP+ G D + AE+ R H A+E ++ L QVQQ
Sbjct: 1800 AYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQV 1859
Query: 1856 QDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDL 1915
QD RLQ AYAG+KAE I Q V+ AW L + A RR L+DT DKFRFF R+L
Sbjct: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVREL 1919
Query: 1916 LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQ 1975
+ WM+ + Q++ QERPRDVSS +L++K QGI AEIE R+ FS+C+++G+ LL R H
Sbjct: 1920 MLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHY 1979
Query: 1976 ASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASG 2035
A+EEI EKL Q+ +RR+E EKW+ + + L+++LEV F RDA +AEAWL +QEP + S
Sbjct: 1980 AAEEISEKLSQLQARRQETAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSA 2039
Query: 2036 DFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQ-IAERPAEETGPQEE 2094
+ G TVD VE LIKRHEAF+KS +W ERF ALEK T LE +E++ +R EE Q
Sbjct: 2040 ELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPP 2099
Query: 2095 EGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEP 2133
E P + S ++W+ QP P
Sbjct: 2100 APEPTASVPPGDLVGGQTAS--------DTTWDGTQPRP 2130
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo
sapiens]
Length = 2564
Score = 1966 bits (5092), Expect = 0.0
Identities = 1029/2124 (48%), Positives = 1421/2124 (66%), Gaps = 50/2124 (2%)
Query: 6 EFENVGNQP-PYSRINARWDAPDDELDNDN-----SSARLFERSRIKALADEREVVQKKT 59
E +N+ P P + ARW++PD + + ++A LFE SRIKALADERE VQKKT
Sbjct: 7 EVDNMEGLPAPNNNPAARWESPDRGWEREQPAASTAAASLFECSRIKALADEREAVQKKT 66
Query: 60 FTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKA 119
FTKWVNSHLARV C I DLY DLRDG +L +LLEVLSGE LP+PT+G+MRIH LENVDKA
Sbjct: 67 FTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHSLENVDKA 126
Query: 120 LQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDAL 179
LQFLKEQRVHLEN+GSHDIVDGNHRL LGL+WTIILRFQIQ I ++T++ RETRSAKDAL
Sbjct: 127 LQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRETRSAKDAL 186
Query: 180 LLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFN 239
LLWCQMKTAGYP VN+ NFT+SW+DGLAFNALIH+HRPDL+DF KL SNA +NL+ AF
Sbjct: 187 LLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANYNLQRAFR 246
Query: 240 VAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIE 299
AE+ LG+ LLDPEDV E PDEKSIITYVV+FYHYFSKMK LAVEGKR+GKV+D +E
Sbjct: 247 TAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIGKVLDQVLE 306
Query: 300 TEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEK 359
K+IE+Y LA++LL WI +T+ +++++KFANSL+GVQQQLQAF+ Y T+EKP KFQEK
Sbjct: 307 VGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLEKPVKFQEK 366
Query: 360 GNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEK 419
GNLEVLLF+IQS++RA N++++ P +G + DI++AW LE+AE+ RE ALR ELIRQEK
Sbjct: 367 GNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALRAELIRQEK 426
Query: 420 LEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVR 479
LE LA+RFD K AMRE+WL+ENQRLV+QDNFGY+L AVEAA KKHEAIE D AAYEERV+
Sbjct: 427 LELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEADIAAYEERVQ 486
Query: 480 ALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH 539
+ +LAQ L E Y+D +R+ A++D++LR W+ L L+ +RR RLE LALQK+FQ+M++
Sbjct: 487 GVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLALQKVFQEMVY 546
Query: 540 SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKG 599
+DWM+E++A LLS E G+HL+E +DLLQKH L+E DIA Q ++V+A+ AA L+F++ +G
Sbjct: 547 MVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQG 606
Query: 600 YQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQI 659
YQPCDPQVI +R++H+ C EL AA R+A+LE S+ LW E++EAESW ++KE++
Sbjct: 607 YQPCDPQVICNRVNHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERL 666
Query: 660 YSSLDYG---------------KDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
+ G DL+S L +HK + EL G A L+Q + +V
Sbjct: 667 LEAAGGGGAAGAAGAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELV 726
Query: 705 ARKQFGHPQIEA--------RIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
A P + R +W +L++ AA ++ LQ+A QF D D L
Sbjct: 727 AAGGAVGPGADTVHLVGLAERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLL 786
Query: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDS 816
WL+DA+RL + D G DE ++R L ++H+ E+E RG + L +Q
Sbjct: 787 DWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAG 846
Query: 817 PDVTH---RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAE 873
P V R+ +L+ +V A LR+Q L++AL +Y +FGE ACELW+GEKE+WL
Sbjct: 847 PLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLS 906
Query: 874 MEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLN 933
M +PD+L+D+EVVQHRF+ LDQEM +LM ++ VN LVE GHP S EV+ QDHLN
Sbjct: 907 MRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLN 966
Query: 934 TRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAI 993
+RW LV +R+E + + L V N+ ++ E + +K + VES G A+
Sbjct: 967 SRWNRIVELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG------AL 1020
Query: 994 QRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQ 1053
Q +LSGLE + A++ R AL E+ L + P Q + Q + L W L + Q
Sbjct: 1021 QWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQAC 1080
Query: 1054 EDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED--MPESLPEAEQLLQQHAGIKDEID 1111
+ + +LQ FL DLD F WL Q+A + +P SL EA+ LL +HA +K+E+D
Sbjct: 1081 GEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVD 1140
Query: 1112 GHQDSYQRVKESGEKVI--QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
++ Y R+ + E ++ G L L + L L+ GW+ L +WE+R L Q
Sbjct: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200
Query: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
+Q F +D +QA +L NQE L+ E P ++E+ E +++ DFL +ME ++ K+ V
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQ 1260
Query: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
+ L+ +GN+Y ++ +E V + +++++N +AQ+ L D LELQ+FL++C EL W
Sbjct: 1261 AAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGW 1320
Query: 1290 INDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL 1349
I++K+L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A
Sbjct: 1321 IHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAAS 1380
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
V +KL + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG
Sbjct: 1381 VRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGG 1440
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDL 1463
DL +VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + L
Sbjct: 1441 DLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL 1500
Query: 1464 LEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTL 1523
LEPL R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L
Sbjct: 1501 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGL 1560
Query: 1524 QNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDA 1583
+ EI H PR+E+VL+R L + + + L LQS+W LREAA R Q L A
Sbjct: 1561 RREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAA 1620
Query: 1584 NEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL 1643
+ +QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL
Sbjct: 1621 FQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQL 1680
Query: 1644 ASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLE 1703
+ + + LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE
Sbjct: 1681 SRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELE 1740
Query: 1704 QWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHS 1763
WI+EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+
Sbjct: 1741 HWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHT 1800
Query: 1764 EAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE- 1822
AAT+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP
Sbjct: 1801 AAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRL 1860
Query: 1823 -DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEV 1881
+A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV
Sbjct: 1861 TTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEV 1920
Query: 1882 SAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELL 1941
W+ LL AC R + TAD RF S RDLLSWM+ I QI ++PRDVSSVE+L
Sbjct: 1921 LQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVL 1980
Query: 1942 MKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEAR 2001
M YHQG+ E+E R + C ELG SLL + ++EI+ +L ++ +R++E++EKW+
Sbjct: 1981 MNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRH 2040
Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
WE L+ +LEV QF+++A VA+AWL AQEP L S + G +VD VE+LI+RHEAF K+ A+W
Sbjct: 2041 WEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAW 2100
Query: 2062 AERFAALEKPTTLELKERQIAERP 2085
ERF++L + TT+E + + +++P
Sbjct: 2101 EERFSSLRRLTTIEKIKAEQSKQP 2124
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 869 bits (2245), Expect = 0.0
Identities = 604/2122 (28%), Positives = 1024/2122 (48%), Gaps = 90/2122 (4%)
Query: 40 FERSRIKALADEREVVQKKTFTKWVNS--HLARVSCRITDLYKDLRDGRMLIKLLEVLSG 97
+E I+ L +Q+KTFTKW+N+ + +I +LY +L DG L++LLE++SG
Sbjct: 5 YETGHIRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISG 64
Query: 98 EMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRF 157
E LP P++G++R+H LEN +AL FL+ +V + +G +IVDG+ L+LGLIW IILRF
Sbjct: 65 EALPPPSRGRLRVHFLENSSRALAFLRA-KVPVPLIGPENIVDGDQTLILGLIWVIILRF 123
Query: 158 QIQDIVVQTQE---GRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHK 214
QI I + +E S K+ALL+WCQ KTA Y +VN+T+F+ SW DGL FNALIH
Sbjct: 124 QISHISLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHA 183
Query: 215 HRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFY 274
HRPDL+D+ L+ HNL AF VAE++LGI LLDPEDV PDE+SI+TYV +Y
Sbjct: 184 HRPDLLDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYY 243
Query: 275 HYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSL 334
HY S++ +R+ K++ ETE + +Y L +DLL WI + L +R F +SL
Sbjct: 244 HYCSRLHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSL 303
Query: 335 TGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINR 394
++Q L AF+ +RT EKPP+ Q++G E LLF +Q+ ++A N++ + PH+G ++++++
Sbjct: 304 PAMRQLLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQ 363
Query: 395 AWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYD 453
W LE AE R AL+ L++ ++LE LARRF KAA+RE++L + ++++ Q
Sbjct: 364 CWAGLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPAS 423
Query: 454 LAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYL 513
LA VEAA ++ +E E R +AL ++A L +E YH + R++ + W L
Sbjct: 424 LATVEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRL 483
Query: 514 QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLM 573
+ LQ +R+++ A+ L Q++ + ++E++ S G+ L EV +LLQ+H L+
Sbjct: 484 LQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLL 543
Query: 574 EADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQL 633
EA ++ G V + T + G +V+Q + L Q + L + R+A L
Sbjct: 544 EAQVSAHGAHVSHLAQQTAELDSSLG---TSVEVLQAKARTLAQLQQSLVALVRARRALL 600
Query: 634 EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHL 693
EQ+ + +F +E E+W+KE Q + G+DL+ + +KHKA E E+ A
Sbjct: 601 EQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVC 660
Query: 694 EQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDAD 753
+ + + AR+ P R + V W L+ LQ A Q+ DA
Sbjct: 661 VDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAA 720
Query: 754 DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF---- 809
+ +WL++ L GQD+ A L ++H L + LE+Q +
Sbjct: 721 EAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARA 780
Query: 810 ------------------------------------------PEEFRDSPDVTHRLQALR 827
P+ D + L
Sbjct: 781 SLFTVNSALSPPGESLRNPGPWSEASCHPGPGDAWKMALPAEPDPDFDPNTILQTQDHLS 840
Query: 828 ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMP--DTLEDLEV 885
+ Y+ + A A LR+ RL+EA+ L+ +LW+ EK+ L + P DTLE +++
Sbjct: 841 QDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWL-EKQTVLLQRVQPQADTLEVMQL 899
Query: 886 VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945
F K L + V+ +A L + S ++++ Q+ L+ RW + L E
Sbjct: 900 KYENFLTALAVGKGLWAE---VSSSAEQLRQRYPGNSTQIQRQQEELSQRWGQLEALKRE 956
Query: 946 RREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK-DLGRDLAGIIAI-QRKLSGLERD 1003
+ + ++ V ++ +C T + D +E+ + D + + Q+K LER
Sbjct: 957 KAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSSEDTCHALQLAQKKTLVLERR 1016
Query: 1004 VAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQL 1063
V +Q+ V ++ E +S P Q GQ + L+ L + +Q+ + + E
Sbjct: 1017 VHFLQSVV--VKVEEPGYAESQPLQ----GQVET-LQGLLKQVQEQVAQRARRQAETQAR 1069
Query: 1064 QAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
Q+FLQ+ W Q + S+++ + A++LL++H + +EI Q+ Q++ ++
Sbjct: 1070 QSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQL-DA 1128
Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
+ + P+ + L L L +WE R L + L Q+F ++ A
Sbjct: 1129 QSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTAT 1188
Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
+N + L + + A + +++ +F + + + G KLV + +
Sbjct: 1189 CANHQAWLHLDNLGEDVREALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAH 1248
Query: 1244 KIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYD 1303
++E++Q I+ + + ++++ L +L+LQ + Q+ EL W+ +K L +
Sbjct: 1249 TVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSG 1308
Query: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDE 1363
RN+ +H+A +EL + +E + G++L+ +P + +L+ L W+
Sbjct: 1309 ARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEA 1368
Query: 1364 LQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKR 1423
L E+ L A + L+ D + + +E L+S + G+DL S R+ + ++
Sbjct: 1369 LNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQ 1428
Query: 1424 VEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEK-RFLDLLE-PLGRRKKQLESSRAKL 1481
+E + ++ L + M + + + R L+LL+ L R QL++S
Sbjct: 1429 LESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHLAIRGLQLQASVELH 1488
Query: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541
Q E WV E +P Y L Q +K++ LQ E+ H +V+ VL G
Sbjct: 1489 QFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSG 1548
Query: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601
+ L + Q + E+ L+ W L A R Q L+ A QQY+LD E E W+
Sbjct: 1549 RSLAASGHPQAQHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVE 1608
Query: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661
E+ V S + +DE + ++ +H Q + Y ++++L AQ L PE +++
Sbjct: 1609 EKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRV 1668
Query: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWI-SEKELVASSPEMGQ 1720
+ Q ++ + L+++A R R+LE L + RE +DL+ W+ S+K+ +G+
Sbjct: 1669 V--QERLREQLRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGE 1726
Query: 1721 DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
D +H L KF F + +G +RV E L++ GHS + + + L W+
Sbjct: 1727 DPEHALHLCTKFAKFQHQV-EMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWS 1785
Query: 1781 DLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTA 1840
+L EL R L + R E+L + EK LP +V D E+ R H
Sbjct: 1786 ELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQG 1845
Query: 1841 FERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLV 1900
EREL Q+Q+ + A R+Q G +A A+Q ++Q V+ AW L RR QL
Sbjct: 1846 LERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLE 1905
Query: 1901 DTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960
RF + RD SW + + ++ +E ++ SS L + HQ + AE+E R K +
Sbjct: 1906 RARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQ 1965
Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
+LG+ L ++E++E+L+ + +R ++ + W + ERL+ + F R+
Sbjct: 1966 QATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGR 2025
Query: 2021 AEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAF-------EKSTASWAERFAALEKPTT 2073
E L AQE L + G +V+ VE+LI++HE F +K A+ ER L +P
Sbjct: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRV 2085
Query: 2074 LE-----LKERQIAERPAEETG 2090
+ L+ R + AE G
Sbjct: 2086 RDRLPILLQRRMRVKELAESRG 2107
Score = 502 bits (1293), Expect = e-141
Identities = 430/1707 (25%), Positives = 753/1707 (44%), Gaps = 66/1707 (3%)
Query: 391 DINRAWESLEEAEYRRELALRNE----LIRQEKLEQLARRFDRKAAMRETWLSENQRLVA 446
D+ AW L E R ALR+ + ++ LE L + ++ ++
Sbjct: 1779 DLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSL------------- 1825
Query: 447 QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR-ITARKDN 505
+N DL +EA + H+ +E + E +++ L + A ++K Q + R+
Sbjct: 1826 PNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
Query: 506 ILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVED 565
+ + W+ LQ ++ RR +LE L + + W ++ L E +
Sbjct: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
Query: 566 LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625
L H+ + A++ + + T + G + +Q+ + L+ +++
Sbjct: 1946 KLSAHQWLRAELEAREKLWQQATQLGQQALLAAG---TPTKEVQEELRALQDQRDQVYQT 2002
Query: 626 AAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDE 685
A ++ +L+ ++ F E E + +E + G + V L RKH+ F
Sbjct: 2003 WARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKV 2062
Query: 686 LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF 745
L D +EA K P++ R+ + + ++K+LA L +
Sbjct: 2063 LTAQDK------KEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLM 2116
Query: 746 FQFQGDADDLKAWLQD-AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ 804
F A + W+Q A +L G + L KH+ F E++ VM + +
Sbjct: 2117 ASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPL-LKHQAFEAEVQAHEEVMTSVAK 2175
Query: 805 QAQGF-PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELW 863
+ + + + +V+ RLQ LR+ ++ + LR Q L++ + D E W
Sbjct: 2176 KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDLAEAW 2235
Query: 864 MGEKEKWLAEMEMPDTLEDLE-VVQHRFDILDQEMKTLMTQIDGVNLAANS--LVESGHP 920
+ EKE +M + D +DLE +Q R + + + + + + S ++ +
Sbjct: 2236 IQEKE---VKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNR 2292
Query: 921 RSREVK---QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV 977
EVK Q + LN RW +F + ++ ++ AL +H + + +K I +K ++
Sbjct: 2293 DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALI 2352
Query: 978 ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQK 1037
++ D G+DL + + RK LER+V IQA+V++LERE +L PE + RQ+
Sbjct: 2353 QAL-DCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQ 2411
Query: 1038 HLEELWQGLQQSLQGQE---DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM---PE 1091
+ E W L+ Q + D L + +LQA LQ+L L Q+ A D P
Sbjct: 2412 EVAESWWQLRSRAQKRREALDALHQAQKLQAMLQEL------LVSAQRLRAQMDTSPAPR 2465
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
S EA ++L++H K E+D DS + +G++++ P + Q L GL+ +
Sbjct: 2466 SPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAG-HPFSSDIRQVLAGLEQELS 2524
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
+L W+ L Q L Q F ++ E L ++E +LA D L E + K +
Sbjct: 2525 SLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHK 2584
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
+E K+ + + L G+ + + Q + R +A L
Sbjct: 2585 MLEWDLEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLE 2644
Query: 1272 DNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLEN 1331
+ +LQ FLQ+ QE+ W+ +K L + + + L + K Q F AEL + +
Sbjct: 2645 ELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQE 2704
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADL 1391
+ EG++L+ + + ++LE L LW ELQ +++K L A + ++ +L
Sbjct: 2705 LQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEEL 2764
Query: 1392 NKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD 1451
W+ +E +LR+ G+ L V +L + +E V+ + + L Q + EG
Sbjct: 2765 ENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHC 2824
Query: 1452 ADLSIEK-------RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
+E+ RF L EPL R+ LE+ L+ RD ++E WV+E+LPLA +
Sbjct: 2825 LAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQ 2884
Query: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
DYG +L V+ +++Q L++E+ H VL G +LV+A ++ R+ L+
Sbjct: 2885 DYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEK 2944
Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLK 1624
+ LR AA R L+ A EAQQ+ + EA +W+ E+ + S+++ E +L+
Sbjct: 2945 AMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLR 3004
Query: 1625 RHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKR 1684
R +R +E + I++L A L S +PE +++ V + +A L AE R
Sbjct: 3005 RLEATKRDLEAFSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGH 3064
Query: 1685 KLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQ 1744
L+ L QL+RET L+ W++ K A S + GQD + V +L +KF F +E ++GQ
Sbjct: 3065 GLQEQLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQ 3124
Query: 1745 ERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804
+V + L I + + W L + I R + LAA++++H +
Sbjct: 3125 AKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184
Query: 1805 TGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQ 1863
AE+ G + EK + ED G S+ + + H EREL + +V + Q A RL
Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRL- 3243
Query: 1864 TAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
G+ A +V AW L R L A F ++LL+W +
Sbjct: 3244 ----GQLHPAAPGGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQ 3299
Query: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK 1983
++E DV+ E L+ H+ + EI + G+ L+ H S E+ E
Sbjct: 3300 ELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTEC 3359
Query: 1984 LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDS 2043
LQ++ R +E+ E W RW+R + + + AEAWL E L D+GH+V
Sbjct: 3360 LQELEGRLQELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSD 3419
Query: 2044 VEKLIKRHEAFEKSTASWAERFAALEK 2070
VE L+ RH+ EK A+ E+FA ++K
Sbjct: 3420 VELLLHRHQDLEKLLAAQEEKFAQMQK 3446
Score = 399 bits (1026), Expect = e-110
Identities = 396/1725 (22%), Positives = 742/1725 (43%), Gaps = 98/1725 (5%)
Query: 384 HDGKLVSDINRAWESLEE------AEYRRELALRNELIRQEKLEQLA-RRFDRKAAMRET 436
H KLV + A ++ E A++ R L R+E R++ L L + + + A
Sbjct: 1235 HGEKLVQSQHPAAHTVREQLQSIQAQWTR-LQGRSEQRRRQLLASLQLQEWKQDVAELMQ 1293
Query: 437 WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ 496
W+ E + A + G ++ K+ HEA E++ A V AL+ + +EL Q
Sbjct: 1294 WMEEKGLMAAHEPSGARRNILQTLKR-HEAAESELLATRRHVEALQQVGRELLSRRPCGQ 1352
Query: 497 KRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEF 556
+ I R + W L + R L+ ++L + + + + +++++ L S+E
Sbjct: 1353 EDIQTRLQGLRSKWEALNRKMTERGDELQQAGQQEQLLRQLQDAKEQLEQLEGALQSSET 1412
Query: 557 GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
G+ L + L ++H+ +E++ K+ A+ + P ++++ HL
Sbjct: 1413 GQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMA-------ASPAILEETQKHLR 1465
Query: 617 QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
+ E L A R QL+ S L +F + SW+ E S Y + L L
Sbjct: 1466 R-LELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLH 1524
Query: 677 RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ---IEARIKEVSAQWDQLKDLAA 733
RKHK + E++ ++++ + A GHPQ I + +E+ W +L+
Sbjct: 1525 RKHKELQVEVKAHQGQVQRVLSSGRSLAAS---GHPQAQHIVEQCQELEGHWAELERACE 1581
Query: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
+ LQ A F Q+ D +L+ W+++ L+S D G+DE AT L KH+ EEL
Sbjct: 1582 ARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELA 1641
Query: 794 ESRGVMEHLEQQAQGF-----PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEA 847
ME L+Q AQ PE+ R + + +L+AL+EL A R + L+
Sbjct: 1642 IYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQEL-------AATRDRELEGT 1694
Query: 848 LDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQI 904
L L+ E + + W+ +++ A ED E H +F +++ ++
Sbjct: 1695 LRLHEFLREAEDLQGWLASQKQ--AAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRV 1752
Query: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV---DSALRVHNYCV 961
L A SL+E GH V+Q Q L T W L R A+ ++ LRVH
Sbjct: 1753 AACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHR--- 1809
Query: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
D E + +K + + ++ RDL G+ A R GLER++ + ++ L + ++
Sbjct: 1810 DLLEVLTQVQEKATSLPN--NVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGRV 1867
Query: 1022 MDSHP-EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSIT 1080
P Q + QRQ+ + + W LQ+ ++ + L L F + D+ +W +
Sbjct: 1868 QKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARV 1927
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLG 1140
++ + E+ + L H ++ E++ + +Q+ + G++ + P +
Sbjct: 1928 RQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPT-KEVQ 1986
Query: 1141 QRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
+ L L + + + W + L Q F ++ + E IL+ QE +L S+
Sbjct: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046
Query: 1201 EAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAE--GNLYSDKIKEKVQLIEDRHRK 1258
E E IRK E FL KVL+ D + E L ++++++ ++ R +
Sbjct: 2047 EEVEQLIRKHEVFL--------KVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR 2098
Query: 1259 NNEKAQEASVLLRDNLELQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQA 1317
E A+ L +L + +F Q + WI + V + R+ LKHQA
Sbjct: 2099 VKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQA 2158
Query: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSA 1377
F AE+ +HE + ++ +G+ L+ + VSQ+L+ L + W++L+ + Q L
Sbjct: 2159 FEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELED 2218
Query: 1378 ARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGE 1437
R+ LQ WI E ++ D G+DL ++ +L+ E + N + +G+
Sbjct: 2219 RRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR--EFRGNSAGDTVGD 2276
Query: 1438 LFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQ--------------- 1482
A + S+ D L ++ R + ++ + +R+ QL + A
Sbjct: 2277 --ACIRSI----SDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALE 2330
Query: 1483 ---ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
+SR+L++ T ++E+ L Q+ D G +L++VQ ++K++ L+ E+ +VE + +
Sbjct: 2331 IHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLER 2390
Query: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAW 1599
+L + + L R + SW +LR A R + L ++AQ+ L A E
Sbjct: 2391 EVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQK--LQAMLQELL 2448
Query: 1600 IGEQELYVISD--EIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE 1657
+ Q L D P+ A ML+ H + ++ + +I S Q LL+AGHP
Sbjct: 2449 VSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPF 2508
Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
I ++ +++ + L+ +E + +L+ L + +E+W+ KE +S
Sbjct: 2509 SSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEG 2568
Query: 1718 MGQDFDHV--TLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGL 1775
+ + L + K ++ E A ++ + A L GH EA + +
Sbjct: 2569 LWDPLAPMEPLLWKHKMLEWDLEVQA---GKISALEATARGLHQGGHPEAQSALGRCQAM 2625
Query: 1776 NEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFH 1835
L TR L L + E+ + EK+ E+ LD + +
Sbjct: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685
Query: 1836 RVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGR 1895
+ F+ EL Q Q+ Q RL +EAIQ + +E+ A W L D +
Sbjct: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQG-GHPASEAIQERLEELGALWGELQDNSQKK 2744
Query: 1896 RTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
+L + R +L +W+E I ++ + + V L+ + + A ++ +
Sbjct: 2745 VAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKK 2804
Query: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFS 2015
++ A L ++ ++ H ++++ E+ ++++ R K + E + R L + +F
Sbjct: 2805 ARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFF 2864
Query: 2016 RDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
RDA AW+ + P A+ D+G ++ +V L ++H+ E +S
Sbjct: 2865 RDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSS 2909
Score = 324 bits (831), Expect = 5e-88
Identities = 369/1779 (20%), Positives = 738/1779 (41%), Gaps = 71/1779 (3%)
Query: 313 DLLTWIE-QTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQS 371
+L W+E QT+ + + A++L +Q + + F T V K + + E L +
Sbjct: 872 ELQLWLEKQTVLLQRVQPQADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQL----RQ 927
Query: 372 RMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKA 431
R N+ ++ + ++++ W LE + + + L + + E L +
Sbjct: 928 RYPGNSTQIQRQQE-----ELSQRWGQLEALKREKAVQLAHSV---EVCSFLQECGPTQV 979
Query: 432 AMRETWLSENQRLVAQDNFGYDLA-AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
+R+ L Q Q D A++ A+KK T E RV L+ + ++E+
Sbjct: 980 QLRDVLL---QLEALQPGSSEDTCHALQLAQKK-------TLVLERRVHFLQSVVVKVEE 1029
Query: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
Y + + + + + + L +QE + R +R T A Q Q+ + W + ++A
Sbjct: 1030 PGYAESQPLQGQVETLQGLLKQVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQ 1089
Query: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
L S E + + LL++H+ + +I + ++++ + A + D Q + +
Sbjct: 1090 LRSKEVSVDVASAQRLLREHQDLLEEIHLWQERLQQLDAQSQPMA---ALDCPDSQEVPN 1146
Query: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
+ L Q +EL + R+ L++ L KF E+D + + + G+D+
Sbjct: 1147 TLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGREVDGFTATCANHQAWLHLDNLGEDVR 1206
Query: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
L L ++H+ F L L E + +V + + +++ + AQW +L+
Sbjct: 1207 EALSLLQQHREFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQG 1266
Query: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
+ ++ L + +++ D +L W+++ + + E G + L K+H+
Sbjct: 1267 RSEQRRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTL-KRHEAAES 1325
Query: 791 ELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
EL +R +E L+Q + D+ RLQ LR ++ + + R LQ+A
Sbjct: 1326 ELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQQAGQ 1385
Query: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
+ + + + + E L E L + +Q R L+ E +TL ++ +
Sbjct: 1386 QEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALAS 1445
Query: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
A+ + S +++ Q HL R + Q ++ R + +++ +H +C W
Sbjct: 1446 MAHGMAAS----PAILEETQKHLR-RLELLQGHLAIRGLQLQASVELHQFCHLSNMELSW 1500
Query: 970 ITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQK 1029
+ + T L G ++ RK L+ +V A Q +V + + L S Q
Sbjct: 1501 VAEHMPHGSPT-SYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQA 1559
Query: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDM 1089
+ I ++ + LE W L+++ + + L + Q + D+ + + W+ + V+S D
Sbjct: 1560 QHIVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDY 1619
Query: 1090 PESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTG 1149
+L+ +H +++E+ + S + + ++ + + G PE + Q E L
Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQ-TLTGPEVPEQQRVVQ--ERLREQ 1676
Query: 1150 WNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP-PDSLEAAEAGIR 1208
AL + +R L L EF ++A+ + L++Q+ E + E A
Sbjct: 1677 LRALQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCT 1736
Query: 1209 KFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASV 1268
KF F +E +V + L+ G+ ++++ Q ++ + E Q
Sbjct: 1737 KFAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGH 1796
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
LRD ++ E+ + +K + + + L + HQ EL E
Sbjct: 1797 ALRDTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQ 1856
Query: 1329 L-ENIDAEGK-QLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ 1386
L E ++ G+ Q + PQ A V Q+ +A+ + W LQ +++ L AR
Sbjct: 1857 LQELLETAGRVQKLCPGPQAHA-VQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRT 1915
Query: 1387 THADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMG 1446
D W + + L+ ++ ++ +S L+ + + ++ R+ +L+ Q +G
Sbjct: 1916 AVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEARE----KLWQQATQLG 1971
Query: 1447 EEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLED------------ETLWV 1494
++ A + K + L L ++ Q+ + A+ Q E E +
Sbjct: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031
Query: 1495 EERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD 1554
+ + L SA G++++ V+ ++K++ ++L + E L+ + + +
Sbjct: 2032 AQEVSLKTSA-LGSSVEEVEQLIRKHEVFL-KVLTAQDKKEAALRERLKTLRRPRV---- 2085
Query: 1555 LEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPK 1614
+RL L R++E A R L + + A +AE WI + P
Sbjct: 2086 -RDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPG 2144
Query: 1615 DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPE-GEQIIRLQGQVDKHYA 1673
D + L +H + V+ + + +A + + LL+ HP GE RLQG + KH+
Sbjct: 2145 DLRDKLKPLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQG-LRKHWE 2203
Query: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
L+ R ++LE+ + + + D E WI EKE+ + ++GQD +H LR + R
Sbjct: 2204 DLRQAMALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLR 2263
Query: 1734 DFARETG--AIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
+F + +G + +++ +L + E I + + LN WA + Q
Sbjct: 2264 EFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQ 2323
Query: 1792 LLAASYDLHRYFYTGAEILGLIDEKHRELPE-DVGLDASTAESFHRVHTAFERELHLLGV 1850
L + ++H + I EK + D G D + + R H ERE+H +
Sbjct: 2324 QLEGALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQA 2383
Query: 1851 QVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS 1910
QV+ + RL + E A +++++QEV+ +W L RR L + +
Sbjct: 2384 QVESLEREVGRL-CQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQA 2442
Query: 1911 MARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
M ++LL + + Q++T PR +++ HQ AE+++ + + S G+ LL
Sbjct: 2443 MLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLL 2502
Query: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEP 2030
H S +IR+ L + + W+ +L+ LE+ F E WL ++E
Sbjct: 2503 TAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKED 2562
Query: 2031 YLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALE 2069
LAS + +E L+ +H+ E A + +ALE
Sbjct: 2563 SLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALE 2601
Score = 299 bits (765), Expect = 2e-80
Identities = 365/1756 (20%), Positives = 723/1756 (41%), Gaps = 91/1756 (5%)
Query: 396 WESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLA 455
WE+L R+ +EL + + EQL R+ L + + + G DL
Sbjct: 1366 WEALN----RKMTERGDELQQAGQQEQLLRQLQDAKEQ----LEQLEGALQSSETGQDLR 1417
Query: 456 AVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQE 515
+ + +K+H+ +E+++ ++ AL +A + I LR LQ
Sbjct: 1418 SSQRLQKRHQQLESESRTLAAKMAALASMAHGMAAS-----PAILEETQKHLRRLELLQG 1472
Query: 516 LLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEA 575
L R +L+ ++ L + + W+ E H + + L + L +KHK ++
Sbjct: 1473 HLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQSLHRKHKELQV 1532
Query: 576 DIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635
++ +V+ + ++ Q Q I ++ LE + EL R L+Q
Sbjct: 1533 EVKAHQGQVQRVLSSGRSLAASGHPQA---QHIVEQCQELEGHWAELERACEARAQCLQQ 1589
Query: 636 SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695
+ ++F ++ E E W++EK + SS DYG+D + L L KH+A ++EL + +E+
Sbjct: 1590 AVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLINKHQALQEELAIYWSSMEE 1649
Query: 696 IFQEAHGMVARKQFGHPQI-EARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADD 754
+ Q A + + ++ + R++E Q L++LAA + L+ +F +A+D
Sbjct: 1650 LDQTAQTLTGPEVPEQQRVVQERLRE---QLRALQELAATRDRELEGTLRLHEFLREAED 1706
Query: 755 LKAWLQDAHRLLSG-EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEF 813
L+ WL + G E +G+D L K F ++E + A+ E
Sbjct: 1707 LQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEMGSQRVAACRLLAESLLERG 1766
Query: 814 RDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLA 872
+ P V R Q L+ + ++ R L++ V + + EK L
Sbjct: 1767 HSAGPMVRQRQQDLQTAWSELWELTQARGHALRDTETTLRVHRDLLEVLTQVQEKATSLP 1826
Query: 873 EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE-SGHPRSREVKQYQDH 931
D L LE L++E+ Q+ + A + + P++ V+Q Q
Sbjct: 1827 NNVARD-LCGLEAQLRSHQGLERELVGTERQLQELLETAGRVQKLCPGPQAHAVQQRQQA 1885
Query: 932 LNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991
+ W Q + +RR ++ A + + + + W + ++ + +G +
Sbjct: 1886 VTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPL 1945
Query: 992 AIQRKLSGLERDVAAIQARVDALERESQ---QLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
KLS + A ++AR ++ +Q Q + + +++ + + L++ + Q
Sbjct: 1946 ----KLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQ 2001
Query: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
+ +++ L Q Q FL++ + L+ + ++ + + S+ E EQL+++H
Sbjct: 2002 TWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLK 2061
Query: 1109 EIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
+ ++E + + + + D +LL +R+ + + ESR H L
Sbjct: 2062 VLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMR--------VKELAESRGHALHAS 2113
Query: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
L F + A QAE + L PP L + K + F ++ + + + S
Sbjct: 2114 LLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFEAEVQAHEEVMTSV 2173
Query: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-LQNFLQNCQEL 1286
G L+A+ + + ++ +++Q + RK+ E ++A L LE +NFL+ Q +
Sbjct: 2174 AKKGEALLAQSHPRAGEVSQRLQGL----RKHWEDLRQAMALRGQELEDRRNFLEFLQRV 2229
Query: 1287 TL---WINDKLLTSQ--DVSYD--EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL 1339
L WI +K + D+ D L + + + A + + +I QL
Sbjct: 2230 DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQL 2289
Query: 1340 MDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAME 1399
+ P+ ++ Q+ L+ W Q L A + + ++ K I E
Sbjct: 2290 KNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKE 2349
Query: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKR 1459
+++ D GKDL SV R+L K + +E +V+ + ++ L +V + + +A + R
Sbjct: 2350 ALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHR 2409
Query: 1460 FLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQS--ADYGTNLQT----- 1512
++ E + + + + R L + ++E L AQ A T+
Sbjct: 2410 QQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVE 2469
Query: 1513 VQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
+ ++++Q + E+ T + GQQL+ A D+ + L L+ L A
Sbjct: 2470 ARRMLEEHQECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGA 2529
Query: 1573 AAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRA 1632
+L+ A E Q + ++ E W+ +E + S+ + +L +H +
Sbjct: 2530 WQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWD 2589
Query: 1633 VEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENMYH 1691
+E I L + A+GL GHPE + + R Q + + A + A R+ +LE +
Sbjct: 2590 LEVQAGKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQ-AGTRRHRLEELRQ 2648
Query: 1692 LFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751
L +++ ++ W+ EK LVA + D + K ++F E A + +
Sbjct: 2649 LQAFLQDSQEVAAWLREKNLVALEEGL-LDTAMLPAQLQKQQNFQAELDA-SMHQQQELQ 2706
Query: 1752 AFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILG 1811
+RL+ GH + I E + L +W +L + ++ L + + R + E+
Sbjct: 2707 REGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELEN 2766
Query: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQ--VQQFQDVATRLQTAYAGE 1869
++ P +V L A T V A LLG Q ++ D R A G+
Sbjct: 2767 WLE------PIEVELRAPT------VGQALPGVGELLGTQRELEAAVDKKARQAEALLGQ 2814
Query: 1870 K----------AEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWM 1919
A+ ++ + + + +++L + RRT L + +FF A + ++W+
Sbjct: 2815 AQAFVREGHCLAQDVEEQARRLLQRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWV 2874
Query: 1920 ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE 1979
+ + Q+ + +S+V L + HQ + +E+ + L G L+Q H A+ E
Sbjct: 2875 QEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE 2934
Query: 1980 IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ ++QQ+ + + R L+ E QF + A +WL + L S D GH
Sbjct: 2935 VAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGH 2994
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP---AEETGPQEEEG 2096
+ ++ + L++R EA ++ +++ R L++ L L+ R+ E P A+ +E
Sbjct: 2995 SAEATQALLRRLEATKRDLEAFSPRIERLQQTAAL-LESRKNPESPKVLAQLQAVREAHA 3053
Query: 2097 ETAGEAPVSHHAATER 2112
E A H E+
Sbjct: 3054 ELLRRAEARGHGLQEQ 3069
Score = 165 bits (417), Expect = 5e-40
Identities = 167/813 (20%), Positives = 334/813 (41%), Gaps = 31/813 (3%)
Query: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
+ ++ W L++ ++ L Q+ E L R R E WL + +
Sbjct: 2727 LEELGALWGELQDNSQKKVAKL------QKACEAL--RLRRSMEELENWLEPIEVELRAP 2778
Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
G L V +E + AL AQ +E + + + + +L+
Sbjct: 2779 TVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQ 2838
Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
+ L+E LQ RR LE L K F+D + W+ E + ++G+ L V L +
Sbjct: 2839 RFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
+H+ +E++++ + + K + + + + R+ LE+ L AA
Sbjct: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHE---VAARVQQLEKAMAHLRAEAAR 2955
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
R+ L+Q++ +F E+ EA SW+ E+ + S D G + L R+ +A + +L
Sbjct: 2956 RRLLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEA 3015
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+E++ Q A + +RK P++ A+++ V +L A LQ+ Q
Sbjct: 3016 FSPRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQL 3075
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
+ + L AWL +D GQD + L +K F +E++ + ++ G
Sbjct: 3076 ERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG 3135
Query: 809 FPEEFRDSPDVTHRLQALRELYQQVVAQAD----LRQQRLQEALDLYTVFGETDACELWM 864
E R +P +QA R + + D R + L A ++++ + M
Sbjct: 3136 TLE--RGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRM 3193
Query: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
EK + + +L + +Q + L++E++ + ++ + A L +
Sbjct: 3194 QEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGG 3253
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
+ + Q+ W Q ER + + A + H + C+E W ++ ++ S+++L
Sbjct: 3254 LAKVQE----AWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELA-SSEELA 3308
Query: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
D+AG + + L +++ + + L +E QQL+D+ ++ + + LE Q
Sbjct: 3309 EDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQ 3368
Query: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
L+++ + E LQ Q L+ +AWL+ + + D S+ + E LL +H
Sbjct: 3369 ELEEAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ 3428
Query: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT- 1163
++ + ++ + +++++ + + E LL Q L+ G + W H
Sbjct: 3429 DLEKLLAAQEEKFAQMQKT-------EMEQELLLQPQELKPGRAGSSLTSFQWRPSGHQG 3481
Query: 1164 LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEP 1196
L L +DAK + + E+ HL P
Sbjct: 3482 LGAQLAETRDPQDAKGTPTMEGSLEFK-QHLLP 3513
Score = 143 bits (361), Expect = 2e-33
Identities = 140/601 (23%), Positives = 259/601 (43%), Gaps = 23/601 (3%)
Query: 297 AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
A+E ++ K+ A + + W+++ + + ++ + SL+ V + LQ ++ +E
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAV-RHLQ--EQHQNLESEMSS 2909
Query: 357 QEKGNLEVLLFTIQSRMRANNQKVYTPHD-GKLVSDINRAWESLEEAEYRRELALRNELI 415
E V+L T ++A + + H+ V + +A A R E A R L+
Sbjct: 2910 HE-ALTRVVLGTGYKLVQAGH---FAAHEVAARVQQLEKAM-----AHLRAEAARRRLLL 2960
Query: 416 RQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYE 475
+Q Q A++F + +WL+E ++ ++ G+ A +A ++ EA + D A+
Sbjct: 2961 QQ---AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017
Query: 476 ERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQ 535
R+ L+ A LE + ++ A+ + + L ++R L+ L L +L +
Sbjct: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLER 3077
Query: 536 DMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFT 595
+ L W+ A S ++G+ L V+ L +K ++ G + K L T
Sbjct: 3078 ETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLG-QAKVYALRKLAGT 3136
Query: 596 EGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE 655
+G P IQ + S +E +E L R L + + F E + ++E
Sbjct: 3137 LERGAPRRYPH-IQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQE 3195
Query: 656 KEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIE 715
K + D G L+SV LQ++H+ E EL ++ + ++ EA R HP
Sbjct: 3196 KTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVARLQTEA----CRLGQLHPAAP 3251
Query: 716 ARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDE 775
+ +V W L+ A + L A F G +L AW Q+ L S E++ +D
Sbjct: 3252 GGLAKVQEAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLAWAQERQELASSEELAEDV 3311
Query: 776 GATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVV 834
L +H++ +E+ E R + L Q+ Q + S +VT LQ L Q++
Sbjct: 3312 AGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELE 3371
Query: 835 AQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILD 894
LR QR E+ L + + E W+ E L + + ++ D+E++ HR L+
Sbjct: 3372 EAWALRWQRCAESWGLQKLRQRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQDLE 3431
Query: 895 Q 895
+
Sbjct: 3432 K 3432
>gi|115430239 spectrin, beta, non-erythrocytic 4 isoform sigma5 [Homo
sapiens]
Length = 678
Score = 577 bits (1488), Expect = e-164
Identities = 304/653 (46%), Positives = 424/653 (64%), Gaps = 8/653 (1%)
Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQK 1353
+L ++D + ++ LH +WL+HQAF+AELA ++ WLE I+ EG+QLM EKP+ A V +K
Sbjct: 1 MLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKK 60
Query: 1354 LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTS 1413
L + + W EL++TT+ K + L A +D +Q+ A+L+K + ME QL+ DPG DL +
Sbjct: 61 LGEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT 120
Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQV------PSMGEEGGDADLSIEKRFLDLLEPL 1467
VN L KL+ +E QV E+GEL AQ P+ E G+ ++ +R + LLEPL
Sbjct: 121 VNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPL 180
Query: 1468 GRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527
R++ L +S+ Q++ DL+DE WV+ERLPLA + G LQ VQ +KKNQ L+ EI
Sbjct: 181 QERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREI 240
Query: 1528 LGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587
H PR+E+VL+R L + + + L LQS+W LREAA R Q L A + +
Sbjct: 241 QAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVE 300
Query: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647
QYY D E EAW+GEQEL ++S++ KDE+ + +LK+HL+ ++ VE+Y +I QL+ +
Sbjct: 301 QYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQC 360
Query: 1648 QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWIS 1707
+ LL GHP+ EQI R Q QVD+ Y LK++ EER+ LE Y L+QL R+ +LE WI+
Sbjct: 361 RALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIA 420
Query: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
EKE+VA SPE+GQDF+HV++L++KF +FA ETG G+ER+ VN ++ LI+ GH+ AAT
Sbjct: 421 EKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAAT 480
Query: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPE--DVG 1825
+AEWKDGLNE WA+LLEL+ TR QLLAAS +LH++F E+ G I+EK R LP
Sbjct: 481 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 540
Query: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAW 1885
+A S R AFE +L LL QV+Q Q+ A +L+T YAGE AEAI ++EQEV W
Sbjct: 541 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGW 600
Query: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSV 1938
+ LL AC R + TAD RF S RDLLSWM+ I QI ++PR SS+
Sbjct: 601 KELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRCPSSL 653
Score = 161 bits (407), Expect = 7e-39
Identities = 131/650 (20%), Positives = 274/650 (42%), Gaps = 7/650 (1%)
Query: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
L+A+D D + +H+A + A +E + +E Q+L +E + +
Sbjct: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
Query: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
I + W+ L+ Q++ ++L +L Q + +++ L + G L V
Sbjct: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATV 121
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
L+K + ME+ + +V + A T +P +++ +R + + + L
Sbjct: 122 NSQLKKLQSMESQVEEWYREVGELQAQTAALP----LEPASKELVGERQNAVGERLVRLL 177
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
R+ L SK L + ++D+ +W++E+ + + G L +V +K++
Sbjct: 178 EPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLR 237
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743
E++ LE++ + A + + + + ++++ + W L++ A ++ L A
Sbjct: 238 REIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDAAF 297
Query: 744 NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLE 803
Q+ D +++AWL + L+ ED G+DE +T L KKH + +E + L
Sbjct: 298 QVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLS 357
Query: 804 QQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACEL 862
+Q + E DS ++ R + LY + + R+ L++ LY + + E
Sbjct: 358 RQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEH 417
Query: 863 WMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTL-MTQIDGVNLAANSLVESGHPR 921
W+ EKE E+ E + V+Q +F E ++ VN + L+E GH
Sbjct: 418 WIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTA 477
Query: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
+ + +++D LN W L+ R + + ++ +H + D E I +K + +
Sbjct: 478 AATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLT 537
Query: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLE 1040
++QR L E D+ + ++V L+ + QL + E E I R++ +
Sbjct: 538 TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL 597
Query: 1041 ELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMP 1090
+ W+ L + + + + F + D +W+ + + D P
Sbjct: 598 QGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKP 647
Score = 105 bits (261), Expect = 6e-22
Identities = 125/664 (18%), Positives = 278/664 (41%), Gaps = 42/664 (6%)
Query: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRD-SPDVTHRL 823
L++ + +D +H+ F+ EL +++ +E +E++ Q +E + + V +L
Sbjct: 2 LMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKL 61
Query: 824 QALRELYQQVVAQADLRQQRLQEAL---DLYTVFGETDACELWMGEKEKWLAEMEMPDTL 880
+R+ + ++ + + ++L EA L F E D L M E L +++ L
Sbjct: 62 GEIRQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHM---ESQLQDVDPGGDL 118
Query: 881 EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAF 939
+ + ++ +++ ++ L A + P S+E V + Q+ + R
Sbjct: 119 ATVNSQLKKLQSMESQVEEWYREVG--ELQAQTAALPLEPASKELVGERQNAVGERLVRL 176
Query: 940 QTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
+ ERR + ++ +H D ++ W+ ++ + T + G L + +K G
Sbjct: 177 LEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT-ERGNGLQAVQQHIKKNQG 235
Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE 1059
L R++ A R++ + + L + E + + + L+ W GL+++ + ++ +L
Sbjct: 236 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 295
Query: 1060 VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQR 1119
Q++ + D+ + +AWL + + SED + QLL++H ++ ++ +++S +
Sbjct: 296 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 355
Query: 1120 VKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK 1178
+ +++ G D E + +R +D + AL + E R L Q + +
Sbjct: 356 LSRQCRALLEMGHPDSEQ--ISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVS 413
Query: 1179 QAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSM-ENNRDKVLSPVDSGNKLVAE 1237
+ E ++ +E E E KF +F R+++ + ++L+
Sbjct: 414 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 473
Query: 1238 GNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK---- 1293
G+ + + E + + + E + LL + EL F + +EL I +K
Sbjct: 474 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 533
Query: 1294 -LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQF------ 1346
LT+ A ++ L + E L+ + ++ +QL + Q
Sbjct: 534 PRLTTPPEPRPSASSMQR----------TLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAG 583
Query: 1347 ---TALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQL 1402
A+ S++ E L W EL + ++ H+S+ + LR + DL W+ + Q+
Sbjct: 584 EHAEAIASREQEVLQG-WKELLSACEDARLHVSSTADA-LRFHSQVRDLLSWMDGIASQI 641
Query: 1403 RSDD 1406
+ D
Sbjct: 642 GAAD 645
Score = 95.9 bits (237), Expect = 4e-19
Identities = 111/483 (22%), Positives = 206/483 (42%), Gaps = 28/483 (5%)
Query: 287 GKRVGKVIDHAIETEKMI---EKYSGLASDL---LTWIEQTITVLNSRKFANSLTGVQQQ 340
G+R+ ++++ E +++ ++ +A DL L W+++ + + + N L VQQ
Sbjct: 170 GERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQH 229
Query: 341 LQAFSTYRTVEKPPKFQEKG-NLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESL 399
++ R + Q G LE +L + + + G + + AW L
Sbjct: 230 IKKNQGLRR-----EIQAHGPRLEEVLERAGALASLRSPEAEAVRRG--LEQLQSAWAGL 282
Query: 400 EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEA 459
EA RR+ L ++EQ FD A E WL E + L+ ++ G D +
Sbjct: 283 REAAERRQQVLDAAF----QVEQYY--FD--VAEVEAWLGEQELLMMSEDKGKDEQSTLQ 334
Query: 460 AKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQS 519
KKH +E YEE + L + L + + D ++I+ R+ + RL+ L+EL +
Sbjct: 335 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEE 394
Query: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
RR LE L +L + + W+ E + S E G+ V L +K ++ +
Sbjct: 395 RRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGM 454
Query: 580 QG-DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKR 638
G +++ A+ + E G+ + + L + + EL + R L S+
Sbjct: 455 AGRERLAAVNQMVDELIE-CGHTAA--ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE 511
Query: 639 LWKFFWEMDEAESWIKEKEQIYSSLDYGKD-LTSVLILQRKHKAFEDELRGLDAHLEQIF 697
L KFF + E + I+EK + L + S +QR +AFE +L+ L + + Q+
Sbjct: 512 LHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQ 571
Query: 698 QEAHGMVARKQFGHPQ-IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ A + H + I +R +EV W +L + ++ + +F DL
Sbjct: 572 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 631
Query: 757 AWL 759
+W+
Sbjct: 632 SWM 634
Score = 87.8 bits (216), Expect = 1e-16
Identities = 98/455 (21%), Positives = 196/455 (43%), Gaps = 14/455 (3%)
Query: 1624 KRHLRQQRAVEDYGRN---IKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAE 1680
KR LR Q + + +N ++++ Q L+ + + G++ + +A L+ +
Sbjct: 17 KRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQ 76
Query: 1681 ERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETG 1740
+ R+L QL + +L++ + E + G D V K + +
Sbjct: 77 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 136
Query: 1741 AIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDL 1799
+E V + A L ++ E + E ++ + E LLE + R +LL AS +L
Sbjct: 137 EWYRE-VGELQAQTAALPLEPASKEL--VGERQNAVGERLVRLLEPLQERRRLLLASKEL 193
Query: 1800 HRYFYTGAEILGLIDEK-HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
H+ + + L + E+ + + G + + + RE+ G ++++ +
Sbjct: 194 HQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLER 253
Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFR--FFSMARDLL 1916
A L + + E AEA++ +++ +AW L +A A RR Q++D A + +F +A ++
Sbjct: 254 AGALASLRSPE-AEAVRRGLEQLQSAWAGLREA-AERRQQVLDAAFQVEQYYFDVA-EVE 310
Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
+W+ + ++++ +D S L+K H + +E ++ + +LL+ H
Sbjct: 311 AWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD 370
Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
SE+I + QV + E E R L + Q SR S E W+ +E S +
Sbjct: 371 SEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPE 430
Query: 2037 FGHTVDSVEKLIKRHEAFEKSTA-SWAERFAALEK 2070
G + V L ++ F T + ER AA+ +
Sbjct: 431 LGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQ 465
Score = 37.7 bits (86), Expect = 0.12
Identities = 25/128 (19%), Positives = 52/128 (40%)
Query: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWER 2004
HQ AE+ + G+ L+Q + + + +R+KL ++ E+ +A+ +
Sbjct: 22 HQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQ 81
Query: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
L + Q + + + L+ E L D G + +V +K+ ++ E W
Sbjct: 82 LFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYRE 141
Query: 2065 FAALEKPT 2072
L+ T
Sbjct: 142 VGELQAQT 149
Score = 35.8 bits (81), Expect = 0.46
Identities = 51/279 (18%), Positives = 106/279 (37%), Gaps = 13/279 (4%)
Query: 278 SKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGV 337
S++ L V K +G+ A+E + + + S S+L WI + V S + V
Sbjct: 379 SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHV 438
Query: 338 QQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWE 397
+ FS + + + L + + + + T + K +N AW
Sbjct: 439 SVLQEKFSEFAS---ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWK--DGLNEAWA 493
Query: 398 SLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAV 457
L E + R +L+ + +L + F ++ + +RL +
Sbjct: 494 ELLEL-----MGTRAQLLAASR--ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSA 546
Query: 458 EAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-KRITARKDNILRLWSYLQEL 516
+ ++ A E D +VR L++ A +L + + I +R+ +L+ W L
Sbjct: 547 SSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSA 606
Query: 517 LQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAE 555
+ R + +T + + + WMD I + + +A+
Sbjct: 607 CEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD 645
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 574 bits (1479), Expect = e-163
Identities = 450/1732 (25%), Positives = 806/1732 (46%), Gaps = 146/1732 (8%)
Query: 355 KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414
K Q+ E L QSR+ A + G+ + D+N + A ++L +L
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663
Query: 415 IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
+ +L+ + R F+R E WL E + +A D++G DL V+ +KKH +
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 468 ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527
E D AA+++R+ + A++ + + D + I +++ ++ + L+E + +R+Q+L +
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
Query: 528 LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587
L LQ+LF+D+ W+ E + S GK L+ V++LL+KH+ ++A+IA ++KA+
Sbjct: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Query: 588 TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647
T E + D ++ ++ L Q +E L A+ R+ LE S + ++F + +
Sbjct: 844 TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 648 EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707
EAESW++EKE I S DYGKD S L +KH+A +L + ++ + ++A R+
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958
Query: 708 QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761
Q E + V A +D Q K K L ++ N ++ + +D + ++
Sbjct: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018
Query: 762 AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821
A+ + L E L E +G + ++Q +++ V+
Sbjct: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064
Query: 822 RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881
R++ + ELY ++ + R+ L+++ + +F E + + W+ EKE L E+ LE
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 882 DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931
+EV+Q +FD +++K +++ +N A L ES + EV+ Q
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 932 ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
LN RW++ Q L ER + + SA V + D +
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
Query: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024
ET +WI +K + + +T + G DLA + A+QRK G ERD+AA+ +V++L +++L+ S
Sbjct: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
Query: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084
HPE ED+ ++ L + W L + ++ LG+ LQ FL D D +W++ + V
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
Query: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142
+S+++ + + AE LL++H + EID ++Q ++ G++++ PE + Q+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419
Query: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202
L+ LD L + W R L QCL Q F +D +QAE ++ +E L + DSL++
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
EA I+K EDF ++ +K+ + ++L+A G+ I + + DR R+ +
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAEL 1322
E L ++ LQ F ++ E+ WI++KL T+ D SY + N+ +K KHQAF AEL
Sbjct: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFEAEL 1599
Query: 1323 ASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
++ + + G L++ + V +L AL W L + EK+Q L A
Sbjct: 1600 HANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEANK 1659
Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
D + W+S +E L S+D GKDL SVN +L K + +E ++ ++ L +L +
Sbjct: 1660 QQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLNS 1719
Query: 1441 QVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLW 1493
Q S+ D +I RF + R+ +L S Q RD++DE W
Sbjct: 1720 QADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDDEESW 1779
Query: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQ 1553
++E+ L S DYG +L VQ KK++ L+ E+ H P ++ VL G++L + I +
Sbjct: 1780 IKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKE 1839
Query: 1554 DLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIP 1613
++++RL W L++ AA R QRL ++ E QQ+ + +E EAWI E+ V S++
Sbjct: 1840 EIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVASEDYG 1899
Query: 1614 KDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYA 1673
+LK+H + + + + + Q L+ + E I ++ +
Sbjct: 1900 DTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLNGKVS 1959
Query: 1674 GLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFR 1733
L+ A +RK KL+ Q + D +E WI EKE + + G+D V L K
Sbjct: 1960 DLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQE 2019
Query: 1734 DFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
F A QE + N+ A ++L+ A H ++ I L + W+ LL R + L
Sbjct: 2020 TFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKL 2079
Query: 1794 AASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
L + H ED+ L +F + +AF
Sbjct: 2080 ------------------LEAQSHFRKVEDLFL------TFAKKASAFN----------S 2105
Query: 1854 QFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR 1913
F++ L E I+ +E A+++ L + QL + + + F +A
Sbjct: 2106 WFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVAS 2164
Query: 1914 DLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA----EIET 1954
+ +W ++ II++ E + E+ R + +L ++ Q NA ET
Sbjct: 2165 NPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQET 2224
Query: 1955 RSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
R+ +C+ L+ Q +A++ ++++ + S+ K++ + A E L
Sbjct: 2225 RTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2276
Score = 519 bits (1337), Expect = e-146
Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)
Query: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
I+ R ++V ++ + K+L+ ++ L+D+ F FQ DA++L+ W+Q+ ++ S E+
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
Query: 774 DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830
+ T GK KH+ F E++ + G + L++ E S + RL L +
Sbjct: 73 -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
+ ++ + + +L +A L E + W+ +KE + E+ LE +EV+Q +F
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
+ +M +++ VN A L++ HP +K QD +N WQ + L +R+ +
Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
Query: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
A V + D +ET WI +K +++ S D GRDLA + A+ RK GLERD+AA++ +
Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310
Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
V AL E+ +L SHP I +++ L W+ ++ + L + +LQ FL D
Sbjct: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
D +W++ + + ++++ + AE LL +H K EID H+DS++ ESG+ ++
Sbjct: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
Query: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
+D + ++L L AL +WE R QC+ Q F +D +Q + +S Q
Sbjct: 431 GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
E L + + DSL++ EA ++K EDF S+ +K+ + + KL+ + + +
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
Query: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
+ + R +E+A L D+ LQ F ++ EL W+N+K+ T+ D +Y + N
Sbjct: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
Query: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367
L K KHQAF AEL++++ ++ ++ G++L+D V+ ++ + LW +L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427
T+ K L A + D+ W+ +E L SDD GKDLT+V + K +E
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480
V ++ + + Q + G +I+K R+ L EP+ RK++L S
Sbjct: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
Q+ RD+EDE W+ E+ P+A S + G +L VQ +KK+Q LQ EI GH PR++ V Q+
Sbjct: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
Query: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
G +VE +D++ +L L W+ L+ A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 847 GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
Query: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
E+E V S + KDE+ A +LK+H + YG +I+ L +AQ +Q
Sbjct: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959
Query: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709
+ + K L D E+ R+ L N + K E +D + ++
Sbjct: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
Query: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769
+ P Q LL ++ + A+ QE++DN + EA +++
Sbjct: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063
Query: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828
+ E++ LLEL + R +L S F E+ I+EK L E+VG D
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
Query: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878
E + F+++L +++ VA L++ E+ +A+Q +E
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912
+E++ W++L A R+QL+ +A + RF A
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242
Query: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972
+ W+E + + T D++SV+ L + H+G ++ ++ E E L+Q
Sbjct: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
Query: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032
+++E+++EK ++ + ++ + R +L ++ +F D +W+ +
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
Query: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
+S + V E L++RH+ + A F A E+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Score = 476 bits (1226), Expect = e-134
Identities = 405/1850 (21%), Positives = 811/1850 (43%), Gaps = 123/1850 (6%)
Query: 274 YHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFAN- 332
YH F ++ L + +E + + A +L WI++ + + + + +
Sbjct: 26 YHRFKELSTLRRQ----------KLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP 75
Query: 333 -SLTGVQQQLQAFSTYRTVEKPP--KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
+L G Q+ QAF K E GNL + S ++ + T +
Sbjct: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI------SEGHFASETIRTR-----L 124
Query: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
+++R WE L E RE ++ L++ +KL Q R + W+++ + +V +
Sbjct: 125 MELHRQWELL--LEKMREKGIK--LLQAQKLVQYLRECEDVM----DWINDKEAIVTSEE 176
Query: 450 FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
G DL VE +KK E +TD AA+EERV + A +L +E + +++ I ++D +
Sbjct: 177 LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
Query: 510 WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
W L+ L R+ +L +Q+ +D+ +I W+ E + + S +FG+ L V+ LL+K
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 570 HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
H+ +E D+A DKVKA+ A + + P IQ + L +E++ +AA R
Sbjct: 297 HEGLERDLAALEDKVKALCAEADRLQQS---HPLSATQIQVKREELITNWEQIRTLAAER 353
Query: 630 KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
A+L S RL +F + + SW+ E + + ++ + D+ L +H+ + E+
Sbjct: 354 HARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAH 413
Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
+ + + ++A + ++ ++ +S + L +L ++ + + F
Sbjct: 414 EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFY 473
Query: 750 GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
D + + W+ L ED+G + AL KKH+DF + L + L++ A
Sbjct: 474 RDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKL 533
Query: 810 PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
+ + DV R AL + +A R+ +L ++ L F ++D + W+ EK
Sbjct: 534 IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
Query: 869 KWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQY 928
K + D +L+ + + E+ ++ID + A L++ H EV
Sbjct: 594 KTATDEAYKDP-SNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652
Query: 929 QDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLA 988
+ + + W+ + + A + + + E+ W+ + + S D G+DL
Sbjct: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLT 711
Query: 989 GIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
+ +Q+K + LE DVAA Q R+D + +++Q D+ E+I ++Q+ L ++ L++
Sbjct: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
Query: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
+ ++ L + +LQ +D++D + W+ + AS + + L + LL++H ++
Sbjct: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
Query: 1109 EIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
EI GH+ + V + G +++ G E + +L L+ W AL R L
Sbjct: 832 EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQRRQDLEDS 889
Query: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
L Q++ DA +AE+ + +E + + ++AEA ++K E + LS
Sbjct: 890 LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD--------LSA 941
Query: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELT 1287
S + + E + +++V +D E +E + L D E ++ +E+T
Sbjct: 942 YGSSIQALRE---QAQSCRQQVAPTDD------ETGKELVLALYDYQE-----KSPREVT 987
Query: 1288 LWIND--KLLTSQDVSYDEARNLHNKWLKHQAFVAEL-----ASHEGWLENID--AEGKQ 1338
+ D LL S + + + + A+V +L AS E LE A ++
Sbjct: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQE 1047
Query: 1339 LMDEKPQFT---ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWI 1395
+D + + T VS +++ + L+ L +++ L + + + +L +WI
Sbjct: 1048 QIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWI 1107
Query: 1396 SAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDAD-- 1453
+ E L S++ G DL V + K + + + L ++ + EG A+
Sbjct: 1108 NEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEV 1167
Query: 1454 -----------------------------------------LSIEKRFLDLLEPLGRRKK 1472
+ +R+ L + R +
Sbjct: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227
Query: 1473 QLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTP 1532
L S+ + RD ++ W+EE+ + +YG +L +VQ +K++ + ++
Sbjct: 1228 LLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD 1287
Query: 1533 RVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
+V + + ++L+++ +DL+E+ L +W L + A R +L D+++ Q++ D
Sbjct: 1288 KVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSD 1347
Query: 1593 ADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652
+ +WI V SDE+ KD GA +L+RH + ++ + Q LL+
Sbjct: 1348 FRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA 1407
Query: 1653 AGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELV 1712
GH +I + +D+ A L+ +R+ L+ L R+ + E W++ +E
Sbjct: 1408 HGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467
Query: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWK 1772
++ + G D V L K DF + + +E++ + AF ++LI AGH I+ +
Sbjct: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
Query: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE 1832
+ + + W L + + L S L ++ EI I EK + ++ D + +
Sbjct: 1527 NEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ 1586
Query: 1833 SFHRVHTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
S H+ H AFE ELH +++ D+ L + A AG + +A++ + ++ WQ L+
Sbjct: 1587 SKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQWQFLVQ 1645
Query: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
A + +L + + F + +D W+ + + +++ +D++SV L+K HQ + A
Sbjct: 1646 KSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEA 1705
Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLE 2010
+I +SL+ + ++++K + R +++ +R +L
Sbjct: 1706 DISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHR 1765
Query: 2011 VCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
+ QF RD E+W+ ++ + S D+G + V+ L K+H+ E A+
Sbjct: 1766 LHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1815
Score = 474 bits (1220), Expect = e-133
Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)
Query: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
IQ+R + + ++ R+ +LE S R F + +E E WI+EK QI S +Y K
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
Query: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
D T++ +KH+AFE E++ + ++ + + M++ F I R+ E+ QW+
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
Query: 728 LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
L + L A+ Q+ + +D+ W+ D +++ E++GQD L KK ++
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 788 FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846
F ++ + + Q A +E ++ Q + +Q++ A RQ +L
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
A ++ + D W+ EKE+ +A + L ++ + + + L++++ L ++
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
Query: 907 VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
+ A+ L +S + +++ ++ L T W+ +TL +ER ++ + R+ + D +
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
Query: 967 SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
+ W+T+ K + + +L D+AG A+ + + ++ A + + + Q L+ +
Sbjct: 374 TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
Query: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
+++ ++ L E L + + + + LQ F +D + W+S + + +
Sbjct: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
Query: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144
ED+ +SL E LL++H + + ++ + E K+IQ Y + + R +
Sbjct: 493 EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549
Query: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202
L + NAL R LA Q+F +D+ + ++ ++ + T + P +L+
Sbjct: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609
Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
++K + F + N+ ++ + +G KL+ + D++ ++ + +K E
Sbjct: 610 K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320
+ + LR+ + Q F +N +++ LW+ + L S D D N+ N KH A
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725
Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
++A+H+ ++ I + +Q D + +K EAL ++ L+ + Q L+ +
Sbjct: 726 DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785
Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
+ D WI E S + GKDL V +L K + ++ ++ + + +
Sbjct: 786 LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493
+ +M EEG A ++ + +L + +R++ LE S Q D + W
Sbjct: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
Query: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549
+ E+ P+ S DYG + + + +KK++ L +++ + ++ + ++ Q Q+ +
Sbjct: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
Query: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608
++L L Q R G + L ++ + ++ ++ + ++ + +
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
Query: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663
S E +E+G+I + +Q +++ R K+ S + +R
Sbjct: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065
Query: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723
++ QV++ Y L ++ E+RK LE F L RE ++L+QWI+EKE +S E+G D +
Sbjct: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762
V +L+ KF DF ++ A + R+ ++N E L G
Sbjct: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807
+++ T + WK LNE W L +L + R QLL +++++ R+
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
Query: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866
E I+EK++ L D G D ++ ++ R H FER+L LG +V + A RL ++
Sbjct: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
Query: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926
E AE +Q K E++ AW +L R+ +L D+ D RF S RDL+SW+ I +
Sbjct: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
Query: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986
+ E +DV+ E L++ HQ EI+ R+ F A + G+ LL H AS EI++KL
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
Query: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
+ R ++ + W R L LE+ F RD AE W+ A+E +L + D G ++DSVE
Sbjct: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
Query: 2047 LIKRHEAFEKSTASWAERFAALE 2069
LIK+HE F+K+ E+ AAL+
Sbjct: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505
Score = 463 bits (1192), Expect = e-130
Identities = 381/1740 (21%), Positives = 781/1740 (44%), Gaps = 100/1740 (5%)
Query: 397 ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447
E+ E+ + RR+ L +R++KLE R F R A E W+ E ++ +
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
Query: 448 DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507
+N+ D ++ +KH+A E + A + L++ + E + + I R +
Sbjct: 70 ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
Query: 508 RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567
R W L E ++ + +L L + ++ +DW+++ +A + S E G+ L VE L
Sbjct: 129 RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
Query: 568 QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627
+K + + D+A ++V + K + Q + ++I+ + + ++ L +A
Sbjct: 189 KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245
Query: 628 GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687
R+ +L + + +F ++DE SWIKEKEQ+ +S D+G+DL SV L RKH+ E +L
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 688 GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747
L+ ++ + EA + QI+ + +E+ W+Q++ LAA L D+ +
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
Query: 748 FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
F D DL +W+ + L++ +++ D AL +H++ E++ + ++ Q
Sbjct: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 808 G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
S +V +L L E ++ +LR+Q+ ++ +DL + +T+ + WM +
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
+E +L ++ D+L+ +E + + + ++ + +I ++ A L+++ H +V
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545
Query: 927 QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
+D L +R A RR + + + + D +E W+ +K K +T + +D
Sbjct: 546 TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603
Query: 987 LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
+ + +K E +++A Q+R+DALE+ Q+L+D + K+++ R + LW+ L
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
Query: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
++ + + L E +Q Q F ++++D + WL + +AS+D + L + L ++HA +
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
+ ++ HQD + ++ + G D E + ++ E L + AL +R LA
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
L Q+ +D + E + +E A L + ++K + + + ++
Sbjct: 782 DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
Query: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
+ GN +V EG+ ++ +K K+ + + KA + L D+L+ Q + + E
Sbjct: 842 AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
Query: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343
W+ +K ++ S D DE + KH+A +++L+++ +I A +Q +
Sbjct: 902 AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957
Query: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401
Q + E + L+D + + +E T + L L + + W + D+
Sbjct: 958 QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013
Query: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
++ DP + + N L + + +R+E++ + +E G L
Sbjct: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064
Query: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511
+E+ + LLE +RK LE S K + R+ + W+ E+ S + G +L+
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560
V++ KK Q ++ + R++D+ + + L + A E+ +E G
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
Query: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
L W L++ A R Q L A+E Q+++ DADE
Sbjct: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
+ WI E+ + +D D + ++H +R + G + L A+ L+ + H
Sbjct: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303
Query: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714
PE E + ++++ ++ L A++RK KL + + L + + DL WI+ + S
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
Query: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771
S E+ +D L ++ ++ E A R AF ++L+ GH + I +
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419
Query: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830
D L++ ADL + R +L +L + + + + L ED G +
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
Query: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
E+ + H F++ +++ ++ Q A +L A K + I ++ EV W+ L
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538
Query: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
+R++L ++ +F ++ +W+ + Q + E +D ++++ + HQ A
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKL-QTASDESYKDPTNIQSKHQKHQAFEA 1597
Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWERLRML 2008
E+ + +++G SL++R A E ++ +L + + + + +K + ++L+
Sbjct: 1598 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEA 1657
Query: 2009 LEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAAL 2068
+ F+ + WL E LAS D+G + SV L+K+H+ E ++ +R L
Sbjct: 1658 NKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDL 1717
Score = 417 bits (1073), Expect = e-116
Identities = 406/1854 (21%), Positives = 795/1854 (42%), Gaps = 140/1854 (7%)
Query: 313 DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
DL +W+ + ++N+ + A+ + G + L + KG ++ + +S
Sbjct: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420
Query: 373 MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430
+ + H SD R E L R L +R+++ EQ + F R
Sbjct: 421 DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
Query: 431 AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
+ W+S+ + + ++ G L +VEA KKHE E +A EE++ AL++ A +L +
Sbjct: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
Query: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
N++ + + R+D +L + L E RR +L + LQ+ F+D W++E K
Sbjct: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594
Query: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
+ E K ++ +QKH+ EA+++ ++ A+ A K + Y + +
Sbjct: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651
Query: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
R++ + +++L + +L ++ + +F +++ E W+ E E +S DYGKDLT
Sbjct: 652 RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711
Query: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
+V LQ+KH E ++ ++ I +A F I+ + + + A+++ LK+
Sbjct: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
Query: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
K+ L D+ Q D +D + W+++ + + + G+D + L KKH+
Sbjct: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
Query: 791 ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
E+ ++ + Q+ EE + DV +L L + ++ + A+A R+Q L+++L
Sbjct: 832 EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
Query: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
F + + E WM EKE + + + E + + + L ++ + I +
Sbjct: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
Query: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
A S + P E + + L +++Y E++ +
Sbjct: 952 QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985
Query: 970 ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018
+T K T + + KD + D G + A +KL D A +R + LE +
Sbjct: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040
Query: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Q+ +D+ ++ G R K +EEL+ L + + ++ +L + + ++
Sbjct: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100
Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127
++ Q W++ + A+ SE++ L + E L ++ + ++ ++ + + + E +
Sbjct: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
Query: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155
+Q E + R ++ L+ W +L +
Sbjct: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
Query: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215
+ E RS L Q F +DA + + + + L L + +A RK E F
Sbjct: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
Query: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275
+ DKV S ++ +L+ ++ ++EK + ++A + L D+ +
Sbjct: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340
Query: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
LQ FL + ++L WIN + L S D + +HQ E+ + G + +
Sbjct: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
G+QL+ + + QKL+ L + +L+ ++ L L + W
Sbjct: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460
Query: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
++A E L ++D G L SV ++ K + + +NV++E++ L A + G A
Sbjct: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520
Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507
I R ++L+ R K Q+ R+KL Q SRD+++ W+ E+L A Y
Sbjct: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580
Query: 1508 --TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGHLQ 1563
TN+Q+ +K+Q + E+ + R+ V+ G L+E + ++ RL L
Sbjct: 1581 DPTNIQSKH---QKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALA 1637
Query: 1564 SSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVML 1623
W L + +A + Q+L++AN+ Q + + + W+ E E + S++ KD +L
Sbjct: 1638 DQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLL 1697
Query: 1624 KRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERK 1683
K+H + + + +K L S+A L+++ + Q+ + ++ + +K +A R+
Sbjct: 1698 KKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRR 1757
Query: 1684 RKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
KL + L Q R+ DD E WI EK+L+ S + G+D V LR K + E A
Sbjct: 1758 AKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA-H 1816
Query: 1744 QERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYF 1803
+ + V ++L D I + E W +L +L R Q L S + ++
Sbjct: 1817 EPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFV 1876
Query: 1804 YTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRL 1862
E I+EK + ED G + + + H AFE + V + DV T
Sbjct: 1877 ANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCTNG 1933
Query: 1863 QTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
Q E I +K + ++ L A A R+ +L + + +F A + SW+
Sbjct: 1934 QDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIG 1993
Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQASEE 1979
++T + RD+SSV+ L+ + +A ++ + + + L + LL +H S+
Sbjct: 1994 EKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKA 2053
Query: 1980 IREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQEPY 2031
I + +M R ++ AR ++L R + ++ F++ AS +W E
Sbjct: 2054 IEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEED 2113
Query: 2032 LASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
L ++++ ++ L + H+AF S +S F L + ++K ++A P
Sbjct: 2114 LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2166
Score = 280 bits (715), Expect = 1e-74
Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)
Query: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
SG KV++ D + +R + + ++ + R L FQ FQ+DA++ E
Sbjct: 4 SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58
Query: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
+ ++ +A E + ++K + F ++ N ++ ++GN +++EG+ S
Sbjct: 59 WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300
+ I+ ++ + + EK +E + L +L +L+ C+++ WINDK ++TS+++
Sbjct: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177
Query: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360
D ++ K + F ++A+HE + ++ +L+ E+ L+ K + ++
Sbjct: 178 GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
Query: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420
W L+ ++ L A + + WI E + SDD G+DL SV +L K
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473
+ +E + ++++ L A+ + + + I+ + +L+ R +
Sbjct: 297 HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356
Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
L S + D D T WV E L + + +++ + + ++Q + EI H
Sbjct: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
Query: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
+ + GQ L+ A ++ E+L L L E R Q+ + Q +Y D
Sbjct: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
Query: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653
++ + W+ +QE +++++++ + +LK+H ++++ I L A L+
Sbjct: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536
Query: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713
H E + + + L + A R+ +L + +HL Q R++D+L+ W++EK A
Sbjct: 537 NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596
Query: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773
+ E +D ++ K + F E A Q R+D + ++LID H +A +
Sbjct: 597 TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
Query: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832
+ +W LLE + + L + ++ +I L L + + +D G D + +
Sbjct: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
Query: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884
+ + H E ++ + +Q +QFQD AG AE I+ K++ + A
Sbjct: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765
Query: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944
++AL + R+ +L D+ + F D +W+ + R +D+ V+ L+K
Sbjct: 766 YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825
Query: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000
HQ + AEI A + G ++++ H A+E+++ KL E+N+KWEA
Sbjct: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878
Query: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057
R + L L+ Q+ DA+ AE+W+ +EP + S D+G DS E L+K+HEA
Sbjct: 879 ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938
Query: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095
+++ AL R+ A+ ++ P ++E
Sbjct: 939 LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966
Score = 219 bits (557), Expect = 3e-56
Identities = 195/860 (22%), Positives = 366/860 (42%), Gaps = 68/860 (7%)
Query: 411 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETD 470
R++L + L+Q +R D E W+SE + + +++ D +++ +KH+A E +
Sbjct: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYK-DPTNIQSKHQKHQAFEAE 1598
Query: 471 TAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
A +R+R + D+ L + + + AR + W +L + + Q+L+
Sbjct: 1599 LHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKLKEAN 1658
Query: 529 ALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAIT 588
Q + W+ E++A L S ++GK L V +LL+KH+L+EADI+ D++K +
Sbjct: 1659 KQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRLKDLN 1718
Query: 589 AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDE 648
+ + D ++D+ + F+++ +MAA R+A+L +S RL +FF +MD+
Sbjct: 1719 SQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMDD 1775
Query: 649 AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
ESWIKEK+ + S DYG+DLT V L++KHK E EL + ++ + +
Sbjct: 1776 EESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNT 1835
Query: 709 FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
G +I+ R+ + W +LK LAA + L+++ + QF + ++ +AW+ + L++
Sbjct: 1836 IGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVAS 1895
Query: 769 EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRLQALR 827
ED G A + L KKH+ F + + + + Q + +++ +++ L
Sbjct: 1896 EDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGLN 1955
Query: 828 ELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQ 887
+ A R+ +L E + D E W+GEKE L + L ++ +
Sbjct: 1956 GKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTLL 2015
Query: 888 HRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSER 946
+ + D ++ + I + + L+ + H +S+ ++ L RW + R
Sbjct: 2016 TKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAAR 2075
Query: 947 REAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIAIQRK 996
++ + L ++ E+ K S +DL L I A++
Sbjct: 2076 KKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2132
Query: 997 LSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ-------S 1049
+++ QA + L +Q+ + LEE W+ LQ+
Sbjct: 2133 HDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELE 2192
Query: 1050 LQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQHAGIK 1107
LQ ++ E +L Q F Q + F W+ T+ + M E E L+
Sbjct: 2193 LQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKH 2252
Query: 1108 DEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWESRSH 1162
EI + +++++ G + E L+L + GL W+ L ++ H
Sbjct: 2253 QEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQH 2306
Query: 1163 TLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
L Q + F+ F KD L++QE+ L E
Sbjct: 2307 NLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDLPMVE 2363
Query: 1205 AG--IRKFEDFLGSMENNRD 1222
G +FE L +++ NRD
Sbjct: 2364 EGEPDPEFEAILDTVDPNRD 2383
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)
Query: 284 AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
A K++ + H + E + ++ AS +W E L NSL ++ +A
Sbjct: 2073 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2132
Query: 344 FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
+R+ + + L L I+S A+N P+ + + W +L++
Sbjct: 2133 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2186
Query: 404 YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458
REL L+ E RQE+ ++L + F + A W+ E + + + G + +E
Sbjct: 2187 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2246
Query: 459 AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
A K+KH+ I A +++ +EDL +E+ D K + + W L +L
Sbjct: 2247 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2302
Query: 519 SRRQRLE 525
+ LE
Sbjct: 2303 RMQHNLE 2309
Score = 45.1 bits (105), Expect = 8e-04
Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)
Query: 316 TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373
+WI + L + + L+ VQ L T+ + FQ++G N+ L + +
Sbjct: 1990 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2047
Query: 374 RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433
++ + H + + + W L R+ L K+E L F +KA+
Sbjct: 2048 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2102
Query: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
+W + + L ++A ++ H+A + ++ + L +L ++++
Sbjct: 2103 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2162
Query: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545
+ + W LQ++++ R L+ Q KL Q+ + W+
Sbjct: 2163 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2222
Query: 546 EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
E + +LL E G ++E +KH+ + A + Q K++ + AA +
Sbjct: 2223 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2275
Query: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
D + + L Q +++L + + LEQ + +EA +KE ++
Sbjct: 2276 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2332
Query: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696
D KD + L H+ F+ LR L L +
Sbjct: 2333 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2362
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 568 bits (1463), Expect = e-161
Identities = 450/1737 (25%), Positives = 806/1737 (46%), Gaps = 151/1737 (8%)
Query: 355 KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNEL 414
K Q+ E L QSR+ A + G+ + D+N + A ++L +L
Sbjct: 610 KVQKHQAFEAELSANQSRIDALEKA------GQKLIDVNHYAKDEVAARMNEVISLWKKL 663
Query: 415 IRQEKLEQLARR-------FDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAI 467
+ +L+ + R F+R E WL E + +A D++G DL V+ +KKH +
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 468 ETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETT 527
E D AA+++R+ + A++ + + D + I +++ ++ + L+E + +R+Q+L +
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADS 783
Query: 528 LALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAI 587
L LQ+LF+D+ W+ E + S GK L+ V++LL+KH+ ++A+IA ++KA+
Sbjct: 784 LRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAV 843
Query: 588 TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMD 647
T E + D ++ ++ L Q +E L A+ R+ LE S + ++F + +
Sbjct: 844 TQKGNAMVEEGHFAAED---VKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADAN 900
Query: 648 EAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARK 707
EAESW++EKE I S DYGKD S L +KH+A +L + ++ + ++A R+
Sbjct: 901 EAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQS--CRQ 958
Query: 708 QFGHPQIEARIKEVSAQWD-QLKDLAAFCKKN-----LQDAENFFQFQGDADDLKAWLQD 761
Q E + V A +D Q K K L ++ N ++ + +D + ++
Sbjct: 959 QVAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPA 1018
Query: 762 AHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTH 821
A+ + L E L E +G + ++Q +++ V+
Sbjct: 1019 AY--------------VKKLDPAQSASRENLLEEQGSIALRQEQIDNQTRITKEAGSVSL 1064
Query: 822 RLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLE 881
R++ + ELY ++ + R+ L+++ + +F E + + W+ EKE L E+ LE
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 882 DLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDH---------- 931
+EV+Q +FD +++K +++ +N A L ES + EV+ Q
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDL-ESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 932 ---------------------------LNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
LN RW++ Q L ER + + SA V + D +
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
Query: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDS 1024
ET +WI +K + + +T + G DLA + A+QRK G ERD+AA+ +V++L +++L+ S
Sbjct: 1244 ETKEWIEEKNQAL-NTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
Query: 1025 HPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAV 1084
HPE ED+ ++ L + W L + ++ LG+ LQ FL D D +W++ + V
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
Query: 1085 ASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQR 1142
+S+++ + + AE LL++H + EID ++Q ++ G++++ PE + Q+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPE---IKQK 1419
Query: 1143 LEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEA 1202
L+ LD L + W R L QCL Q F +D +QAE ++ +E L + DSL++
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
EA I+K EDF ++ +K+ + ++L+A G+ I + + DR R+ +
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGDISSRRNEVLDRWRRLKAQ 1539
Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH-----NKWLKHQA 1317
E L ++ LQ F ++ E+ WI++KL T+ D SY + N+ +K KHQA
Sbjct: 1540 MIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
Query: 1318 FVAELASHEGWLENIDAEGKQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHL 1375
F AEL ++ + + G L++ + V +L AL W L + EK+Q L
Sbjct: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEEL 1435
A D + W+S +E L S+D GKDL SVN +L K + +E ++ ++ L
Sbjct: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
Query: 1436 GELFAQVPSMGEEGG-------DADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLE 1488
+L +Q S+ D +I RF + R+ +L S Q RD++
Sbjct: 1720 KDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFRDMD 1779
Query: 1489 DETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA 1548
DE W++E+ L S DYG +L VQ KK++ L+ E+ H P ++ VL G++L +
Sbjct: 1780 DEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDN 1839
Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI 1608
I +++++RL W L++ AA R QRL ++ E QQ+ + +E EAWI E+ V
Sbjct: 1840 TIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMTLVA 1899
Query: 1609 SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQV 1668
S++ +LK+H + + + + + Q L+ + E I +
Sbjct: 1900 SEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKMKGL 1959
Query: 1669 DKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLL 1728
+ + L+ A +RK KL+ Q + D +E WI EKE + + G+D V L
Sbjct: 1960 NGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSVQTL 2019
Query: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788
K F A QE + N+ A ++L+ A H ++ I L + W+ LL
Sbjct: 2020 LTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAA 2079
Query: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLL 1848
R + L L + H ED+ L +F + +AF
Sbjct: 2080 RKKKL------------------LEAQSHFRKVEDLFL------TFAKKASAFN------ 2109
Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
F++ L E I+ +E A+++ L + QL + + +
Sbjct: 2110 ----SWFENAEEDLTDPVRCNSLEEIK-ALREAHDAFRSSLSSAQADFNQLAELDRQIKS 2164
Query: 1909 FSMARDLLSW------------MESIIRQIETQ---ERPRDVSSVELLMKYHQGINA--- 1950
F +A + +W ++ II++ E + E+ R + +L ++ Q NA
Sbjct: 2165 FRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQ 2224
Query: 1951 -EIETRSKNF-SACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
ETR+ +C+ L+ Q +A++ ++++ + S+ K++ + A E L
Sbjct: 2225 WIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAAMEEAL 2281
Score = 519 bits (1337), Expect = e-146
Identities = 376/1418 (26%), Positives = 673/1418 (47%), Gaps = 93/1418 (6%)
Query: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
I+ R ++V ++ + K+L+ ++ L+D+ F FQ DA++L+ W+Q+ ++ S E+
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-- 72
Query: 774 DEGATRALGK--KHKDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELY 830
+ T GK KH+ F E++ + G + L++ E S + RL L +
Sbjct: 73 -KDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQW 131
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRF 890
+ ++ + + +L +A L E + W+ +KE + E+ LE +EV+Q +F
Sbjct: 132 ELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKF 191
Query: 891 DILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV 950
+ +M +++ VN A L++ HP +K QD +N WQ + L +R+ +
Sbjct: 192 EEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKL 251
Query: 951 DSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQAR 1010
A V + D +ET WI +K +++ S D GRDLA + A+ RK GLERD+AA++ +
Sbjct: 252 FGAAEVQRFNRDVDETISWIKEKEQLMASD-DFGRDLASVQALLRKHEGLERDLAALEDK 310
Query: 1011 VDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
V AL E+ +L SHP I +++ L W+ ++ + L + +LQ FL D
Sbjct: 311 VKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADF 370
Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQG 1130
D +W++ + + ++++ + AE LL +H K EID H+DS++ ESG+ ++
Sbjct: 371 RDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAA 430
Query: 1131 ---QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
+D + ++L L AL +WE R QC+ Q F +D +Q + +S Q
Sbjct: 431 GHYASDE----VREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQ 486
Query: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
E L + + DSL++ EA ++K EDF S+ +K+ + + KL+ + + +
Sbjct: 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVAT 546
Query: 1248 KVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
+ + R +E+A L D+ LQ F ++ EL W+N+K+ T+ D +Y + N
Sbjct: 547 RRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSN 606
Query: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQAT 1367
L K KHQAF AEL++++ ++ ++ G++L+D V+ ++ + LW +L
Sbjct: 607 LQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1368 TKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ 1427
T+ K L A + D+ W+ +E L SDD GKDLT+V + K +E
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEAD 726
Query: 1428 VNVRKEELGELFAQVPSMGEEGGDADLSIEK-------RFLDLLEPLGRRKKQLESSRAK 1480
V ++ + + Q + G +I+K R+ L EP+ RK++L S
Sbjct: 727 VAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLRL 786
Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
Q+ RD+EDE W+ E+ P+A S + G +L VQ +KK+Q LQ EI GH PR++ V Q+
Sbjct: 787 QQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQK 846
Query: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
G +VE +D++ +L L W+ L+ A+ R Q L D+ +AQQY+ DA+EAE+W+
Sbjct: 847 GNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESWM 906
Query: 1601 GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQ 1660
E+E V S + KDE+ A +LK+H + YG +I+ L +AQ +Q
Sbjct: 907 REKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCR-------QQ 959
Query: 1661 IIRLQGQVDKHYA-GLKDVAEERKRK----------LENMYHLFQLKRETDDLEQWISEK 1709
+ + K L D E+ R+ L N + K E +D + ++
Sbjct: 960 VAPTDDETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAA 1019
Query: 1710 ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIA 1769
+ P Q LL ++ + A+ QE++DN + EA +++
Sbjct: 1020 YVKKLDP--AQSASRENLLEEQ------GSIALRQEQIDNQTRITK--------EAGSVS 1063
Query: 1770 EWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP-EDVGLDA 1828
+ E++ LLEL + R +L S F E+ I+EK L E+VG D
Sbjct: 1064 LRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADL 1123
Query: 1829 STAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT-AYAGEKAEAIQNKE--------- 1878
E + F+++L +++ VA L++ E+ +A+Q +E
Sbjct: 1124 EQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 1879 -------------------------QEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMA 1912
+E++ W++L A R+QL+ +A + RF A
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSL-QQLAEERSQLLGSAHEVQRFHRDA 1242
Query: 1913 RDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQR 1972
+ W+E + + T D++SV+ L + H+G ++ ++ E E L+Q
Sbjct: 1243 DETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS 1302
Query: 1973 QHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYL 2032
+++E+++EK ++ + ++ + R +L ++ +F D +W+ +
Sbjct: 1303 HPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
Query: 2033 ASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
+S + V E L++RH+ + A F A E+
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Score = 474 bits (1220), Expect = e-133
Identities = 363/1523 (23%), Positives = 705/1523 (46%), Gaps = 93/1523 (6%)
Query: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGK 667
IQ+R + + ++ R+ +LE S R F + +E E WI+EK QI S +Y K
Sbjct: 15 IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASDENY-K 73
Query: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQ 727
D T++ +KH+AFE E++ + ++ + + M++ F I R+ E+ QW+
Sbjct: 74 DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWEL 133
Query: 728 LKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKD 787
L + L A+ Q+ + +D+ W+ D +++ E++GQD L KK ++
Sbjct: 134 LLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEE 193
Query: 788 FLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ-ALRELYQQVVAQADLRQQRLQE 846
F ++ + + Q A +E ++ Q + +Q++ A RQ +L
Sbjct: 194 FQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQRQGKLFG 253
Query: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDG 906
A ++ + D W+ EKE+ +A + L ++ + + + L++++ L ++
Sbjct: 254 AAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLAALEDKVKA 313
Query: 907 VNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEET 966
+ A+ L +S + +++ ++ L T W+ +TL +ER ++ + R+ + D +
Sbjct: 314 LCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQRFLADFRDL 373
Query: 967 SKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
+ W+T+ K + + +L D+AG A+ + + ++ A + + + Q L+ +
Sbjct: 374 TSWVTEM-KALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQALLAAGH 432
Query: 1027 EQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS 1086
+++ ++ L E L + + + + LQ F +D + W+S + + +
Sbjct: 433 YASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLN 492
Query: 1087 EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--LGQRLE 1144
ED+ +SL E LL++H + + ++ + E K+IQ Y + + R +
Sbjct: 493 EDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNN---HYAMEDVATRRD 549
Query: 1145 GLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAH--LEPPDSLEA 1202
L + NAL R LA Q+F +D+ + ++ ++ + T + P +L+
Sbjct: 550 ALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQG 609
Query: 1203 AEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEK 1262
++K + F + N+ ++ + +G KL+ + D++ ++ + +K E
Sbjct: 610 K---VQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEA 666
Query: 1263 AQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNLHNKWLKHQAFVA 1320
+ + LR+ + Q F +N +++ LW+ + L S D D N+ N KH A
Sbjct: 667 TELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKD-LTNVQNLQKKHALLEA 725
Query: 1321 ELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS 1380
++A+H+ ++ I + +Q D + +K EAL ++ L+ + Q L+ +
Sbjct: 726 DVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVARKQKLADSLR 785
Query: 1381 SDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
+ D WI E S + GKDL V +L K + ++ ++ + + +
Sbjct: 786 LQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQ 845
Query: 1441 QVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQLESSRAKLQISRDLEDETLW 1493
+ +M EEG A ++ + +L + +R++ LE S Q D + W
Sbjct: 846 KGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANEAESW 905
Query: 1494 VEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQ----QLVEAAE 1549
+ E+ P+ S DYG + + + +KK++ L +++ + ++ + ++ Q Q+ +
Sbjct: 906 MREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALREQAQSCRQQVAPTDD 965
Query: 1550 IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVI- 1608
++L L Q R G + L ++ + ++ ++ + ++ + +
Sbjct: 966 ETGKELVLALYDYQEKSPREVTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLD 1025
Query: 1609 -----SDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIR 1663
S E +E+G+I + +Q +++ R K+ S + +R
Sbjct: 1026 PAQSASRENLLEEQGSIAL------RQEQIDNQTRITKEAGSVS--------------LR 1065
Query: 1664 LQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFD 1723
++ QV++ Y L ++ E+RK LE F L RE ++L+QWI+EKE +S E+G D +
Sbjct: 1066 MK-QVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 1724 HVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG---------------------H 1762
V +L+ KF DF ++ A + R+ ++N E L G
Sbjct: 1125 QVEVLQKKFDDFQKDLKA-NESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDE 1183
Query: 1763 SEAATIAEWKDG---------------LNEMWADLLELIDTRMQLLAASYDLHRYFYTGA 1807
+++ T + WK LNE W L +L + R QLL +++++ R+
Sbjct: 1184 TDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDAD 1243
Query: 1808 EILGLIDEKHRELPED-VGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAY 1866
E I+EK++ L D G D ++ ++ R H FER+L LG +V + A RL ++
Sbjct: 1244 ETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQSH 1303
Query: 1867 AGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI 1926
E AE +Q K E++ AW +L R+ +L D+ D RF S RDL+SW+ I +
Sbjct: 1304 P-ESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLV 1362
Query: 1927 ETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQ 1986
+ E +DV+ E L++ HQ EI+ R+ F A + G+ LL H AS EI++KL
Sbjct: 1363 SSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLDI 1422
Query: 1987 VMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
+ R ++ + W R L LE+ F RD AE W+ A+E +L + D G ++DSVE
Sbjct: 1423 LDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEA 1482
Query: 2047 LIKRHEAFEKSTASWAERFAALE 2069
LIK+HE F+K+ E+ AAL+
Sbjct: 1483 LIKKHEDFDKAINVQEEKIAALQ 1505
Score = 470 bits (1210), Expect = e-132
Identities = 405/1855 (21%), Positives = 811/1855 (43%), Gaps = 128/1855 (6%)
Query: 274 YHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFAN- 332
YH F ++ L + +E + + A +L WI++ + + + + +
Sbjct: 26 YHRFKELSTLRRQ----------KLEDSYRFQFFQRDAEELEKWIQEKLQIASDENYKDP 75
Query: 333 -SLTGVQQQLQAFSTYRTVEKPP--KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
+L G Q+ QAF K E GNL + S ++ + T +
Sbjct: 76 TNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMI------SEGHFASETIRTR-----L 124
Query: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
+++R WE L E RE ++ L++ +KL Q R + W+++ + +V +
Sbjct: 125 MELHRQWELL--LEKMREKGIK--LLQAQKLVQYLRECEDVM----DWINDKEAIVTSEE 176
Query: 450 FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
G DL VE +KK E +TD AA+EERV + A +L +E + +++ I ++D +
Sbjct: 177 LGQDLEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
Query: 510 WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
W L+ L R+ +L +Q+ +D+ +I W+ E + + S +FG+ L V+ LL+K
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 570 HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
H+ +E D+A DKVKA+ A + + P IQ + L +E++ +AA R
Sbjct: 297 HEGLERDLAALEDKVKALCAEADRLQQS---HPLSATQIQVKREELITNWEQIRTLAAER 353
Query: 630 KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
A+L S RL +F + + SW+ E + + ++ + D+ L +H+ + E+
Sbjct: 354 HARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAH 413
Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
+ + + ++A + ++ ++ +S + L +L ++ + + F
Sbjct: 414 EDSFKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFY 473
Query: 750 GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
D + + W+ L ED+G + AL KKH+DF + L + L++ A
Sbjct: 474 RDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKL 533
Query: 810 PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
+ + DV R AL + +A R+ +L ++ L F ++D + W+ EK
Sbjct: 534 IQNNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKM 593
Query: 869 KWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQY 928
K + D +L+ + + E+ ++ID + A L++ H EV
Sbjct: 594 KTATDEAYKDP-SNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAAR 652
Query: 929 QDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLA 988
+ + + W+ + + A + + + E+ W+ + + S D G+DL
Sbjct: 653 MNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASD-DYGKDLT 711
Query: 989 GIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ 1048
+ +Q+K + LE DVAA Q R+D + +++Q D+ E+I ++Q+ L ++ L++
Sbjct: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
Query: 1049 SLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKD 1108
+ ++ L + +LQ +D++D + W+ + AS + + L + LL++H ++
Sbjct: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
Query: 1109 EIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQC 1167
EI GH+ + V + G +++ G E + +L L+ W AL R L
Sbjct: 832 EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKA--KLHELNQKWEALKAKASQRRQDLEDS 889
Query: 1168 LGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSP 1227
L Q++ DA +AE+ + +E + + ++AEA ++K E + LS
Sbjct: 890 LQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD--------LSA 941
Query: 1228 VDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELT 1287
S + + E + +++V +D E +E + L D E ++ +E+T
Sbjct: 942 YGSSIQALRE---QAQSCRQQVAPTDD------ETGKELVLALYDYQE-----KSPREVT 987
Query: 1288 LWIND--KLLTSQDVSYDEARNLHNKWLKHQAFVAEL-----ASHEGWLENID--AEGKQ 1338
+ D LL S + + + + A+V +L AS E LE A ++
Sbjct: 988 MKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKLDPAQSASRENLLEEQGSIALRQE 1047
Query: 1339 LMDEKPQFT---ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWI 1395
+D + + T VS +++ + L+ L +++ L + + + +L +WI
Sbjct: 1048 QIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWI 1107
Query: 1396 SAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDAD-- 1453
+ E L S++ G DL V + K + + + L ++ + EG A+
Sbjct: 1108 NEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEV 1167
Query: 1454 -----------------------------------------LSIEKRFLDLLEPLGRRKK 1472
+ +R+ L + R +
Sbjct: 1168 QAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQ 1227
Query: 1473 QLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTP 1532
L S+ + RD ++ W+EE+ + +YG +L +VQ +K++ + ++
Sbjct: 1228 LLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGD 1287
Query: 1533 RVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
+V + + ++L+++ +DL+E+ L +W L + A R +L D+++ Q++ D
Sbjct: 1288 KVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSD 1347
Query: 1593 ADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLS 1652
+ +WI V SDE+ KD GA +L+RH + ++ + Q LL+
Sbjct: 1348 FRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQFGQQLLA 1407
Query: 1653 AGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELV 1712
GH +I + +D+ A L+ +R+ L+ L R+ + E W++ +E
Sbjct: 1408 HGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAF 1467
Query: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWK 1772
++ + G D V L K DF + + +E++ + AF ++LI AGH I+ +
Sbjct: 1468 LNTEDKGDSLDSVEALIKKHEDFDKAIN-VQEEKIAALQAFADQLIAAGHYAKGDISSRR 1526
Query: 1773 DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAE 1832
+ + + W L + + L S L ++ EI I EK + ++ D + +
Sbjct: 1527 NEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQ 1586
Query: 1833 -----SFHRVHTAFERELHLLGVQVQQFQDVATRL--QTAYAGEKAEAIQNKEQEVSAAW 1885
S H+ H AFE ELH +++ D+ L + A AG + +A++ + ++ W
Sbjct: 1587 LSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSE-DAVKARLAALADQW 1645
Query: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYH 1945
Q L+ A + +L + + F + +D W+ + + +++ +D++SV L+K H
Sbjct: 1646 QFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKH 1705
Query: 1946 QGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
Q + A+I +SL+ + ++++K + R +++ +R +L
Sbjct: 1706 QLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKL 1765
Query: 2006 RMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
+ QF RD E+W+ ++ + S D+G + V+ L K+H+ E A+
Sbjct: 1766 NESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
Score = 463 bits (1191), Expect = e-130
Identities = 383/1744 (21%), Positives = 783/1744 (44%), Gaps = 103/1744 (5%)
Query: 397 ESLEEAEYRRELALRN-------ELIRQEKLEQLARR--FDRKAAMRETWLSENQRLVAQ 447
E+ E+ + RR+ L +R++KLE R F R A E W+ E ++ +
Sbjct: 10 ETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQEKLQIASD 69
Query: 448 DNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNIL 507
+N+ D ++ +KH+A E + A + L++ + E + + I R +
Sbjct: 70 ENYK-DPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELH 128
Query: 508 RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLL 567
R W L E ++ + +L L + ++ +DW+++ +A + S E G+ L VE L
Sbjct: 129 RQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQ 188
Query: 568 QKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAA 627
+K + + D+A ++V + K + Q + ++I+ + + ++ L +A
Sbjct: 189 KKFEEFQTDMAAHEERVNEVNQFAAKLIQE---QHPEEELIKTKQDEVNAAWQRLKGLAL 245
Query: 628 GRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELR 687
R+ +L + + +F ++DE SWIKEKEQ+ +S D+G+DL SV L RKH+ E +L
Sbjct: 246 QRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKHEGLERDLA 305
Query: 688 GLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQ 747
L+ ++ + EA + QI+ + +E+ W+Q++ LAA L D+ +
Sbjct: 306 ALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHARLNDSYRLQR 365
Query: 748 FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
F D DL +W+ + L++ +++ D AL +H++ E++ + ++ Q
Sbjct: 366 FLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDSFKSADESGQ 425
Query: 808 G-FPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
S +V +L L E ++ +LR+Q+ ++ +DL + +T+ + WM +
Sbjct: 426 ALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDTEQVDNWMSK 485
Query: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
+E +L ++ D+L+ +E + + + ++ + +I ++ A L+++ H +V
Sbjct: 486 QEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQNNHYAMEDVA 545
Query: 927 QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
+D L +R A RR + + + + D +E W+ +K K +T + +D
Sbjct: 546 TRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKT--ATDEAYKD 603
Query: 987 LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
+ + +K E +++A Q+R+DALE+ Q+L+D + K+++ R + LW+ L
Sbjct: 604 PSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKL 663
Query: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI 1106
++ + + L E +Q Q F ++++D + WL + +AS+D + L + L ++HA +
Sbjct: 664 LEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALL 723
Query: 1107 KDEIDGHQDSYQRVK-ESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
+ ++ HQD + ++ + G D E + ++ E L + AL +R LA
Sbjct: 724 EADVAAHQDRIDGITIQARQFQDAGHFDAEN--IKKKQEALVARYEALKEPMVARKQKLA 781
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
L Q+ +D + E + +E A L + ++K + + + ++
Sbjct: 782 DSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIK 841
Query: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
+ GN +V EG+ ++ +K K+ + + KA + L D+L+ Q + + E
Sbjct: 842 AVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQQYFADANE 901
Query: 1286 LTLWINDK--LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEK 1343
W+ +K ++ S D DE + KH+A +++L+++ +I A +Q +
Sbjct: 902 AESWMREKEPIVGSTDYGKDE-DSAEALLKKHEALMSDLSAYG---SSIQALREQAQSCR 957
Query: 1344 PQFTALVSQK-LEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ- 1401
Q + E + L+D + + +E T + L L + + W + D+
Sbjct: 958 QQVAPTDDETGKELVLALYDYQEKSPREVTM----KKGDILTLLNSTNKDWWKVEVNDRQ 1013
Query: 1402 -------LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
++ DP + + N L + + +R+E++ + +E G L
Sbjct: 1014 GFVPAAYVKKLDPAQSASREN-----LLEEQGSIALRQEQID----NQTRITKEAGSVSL 1064
Query: 1455 ---SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQ 1511
+E+ + LLE +RK LE S K + R+ + W+ E+ S + G +L+
Sbjct: 1065 RMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLE 1124
Query: 1512 TVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQL----VEAAEIDCQDLEERLG------- 1560
V++ KK Q ++ + R++D+ + + L + A E+ +E G
Sbjct: 1125 QVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDET 1184
Query: 1561 -------------------------HLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
L W L++ A R Q L A+E Q+++ DADE
Sbjct: 1185 DSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADE 1244
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGH 1655
+ WI E+ + +D D + ++H +R + G + L A+ L+ + H
Sbjct: 1245 TKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFERDLAALGDKVNSLGETAERLIQS-H 1303
Query: 1656 PE-GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVAS 1714
PE E + ++++ ++ L A++RK KL + + L + + DL WI+ + S
Sbjct: 1304 PESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVS 1363
Query: 1715 SPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI---ERLIDAGHSEAATIAEW 1771
S E+ +D L ++ ++ E A R AF ++L+ GH + I +
Sbjct: 1364 SDELAKDVTGAEALLERHQEHRTEIDA----RAGTFQAFEQFGQQLLAHGHYASPEIKQK 1419
Query: 1772 KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL-PEDVGLDAST 1830
D L++ ADL + R +L +L + + + + L ED G +
Sbjct: 1420 LDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDS 1479
Query: 1831 AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLD 1890
E+ + H F++ +++ ++ Q A +L A K + I ++ EV W+ L
Sbjct: 1480 VEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKGD-ISSRRNEVLDRWRRLKA 1538
Query: 1891 ACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQI--ETQERPRDVSSVELLMKY--HQ 1946
+R++L ++ +F ++ +W+ ++ E+ + P ++ +LL K+ HQ
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
Query: 1947 GINAEIETRSKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWER 2004
AE+ + +++G SL++R A E ++ +L + + + + +K + ++
Sbjct: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQK 1658
Query: 2005 LRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAER 2064
L+ + F+ + WL E LAS D+G + SV L+K+H+ E ++ +R
Sbjct: 1659 LKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDR 1718
Query: 2065 FAAL 2068
L
Sbjct: 1719 LKDL 1722
Score = 420 bits (1080), Expect = e-117
Identities = 408/1856 (21%), Positives = 796/1856 (42%), Gaps = 139/1856 (7%)
Query: 313 DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
DL +W+ + ++N+ + A+ + G + L + KG ++ + +S
Sbjct: 372 DLTSWVTEMKALINADELASDVAGAEALLDRHQ-----------EHKGEIDAHEDSFKSA 420
Query: 373 MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLA--RRFDRK 430
+ + H SD R E L R L +R+++ EQ + F R
Sbjct: 421 DESGQALLAAGH---YASDEVR--EKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRD 475
Query: 431 AAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEK 490
+ W+S+ + + ++ G L +VEA KKHE E +A EE++ AL++ A +L +
Sbjct: 476 TEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQ 535
Query: 491 ENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAH 550
N++ + + R+D +L + L E RR +L + LQ+ F+D W++E K
Sbjct: 536 NNHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNE-KMK 594
Query: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
+ E K ++ +QKH+ EA+++ ++ A+ A K + Y + +
Sbjct: 595 TATDEAYKDPSNLQGKVQKHQAFEAELSANQSRIDALEKAGQKLIDVNHYAKDE---VAA 651
Query: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLT 670
R++ + +++L + +L ++ + +F +++ E W+ E E +S DYGKDLT
Sbjct: 652 RMNEVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLT 711
Query: 671 SVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKD 730
+V LQ+KH E ++ ++ I +A F I+ + + + A+++ LK+
Sbjct: 712 NVQNLQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKE 771
Query: 731 LAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLE 790
K+ L D+ Q D +D + W+++ + + + G+D + L KKH+
Sbjct: 772 PMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQA 831
Query: 791 ELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRLQEALD 849
E+ ++ + Q+ EE + DV +L L + ++ + A+A R+Q L+++L
Sbjct: 832 EIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQ 891
Query: 850 LYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNL 909
F + + E WM EKE + + + E + + + L ++ + I +
Sbjct: 892 AQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSDLSAYGSSIQALRE 951
Query: 910 AANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKW 969
A S + P E + + L +++Y E++ +
Sbjct: 952 QAQSCRQQVAPTDDETGK-----------------------ELVLALYDYQ---EKSPRE 985
Query: 970 ITDK-----TKVVESTKDLGR----DLAGII--AIQRKLSGLERDVAAIQARVDALERES 1018
+T K T + + KD + D G + A +KL D A +R + LE +
Sbjct: 986 VTMKKGDILTLLNSTNKDWWKVEVNDRQGFVPAAYVKKL-----DPAQSASRENLLEEQG 1040
Query: 1019 -----QQLMDSHPEQKEDIGQ---RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDL 1070
Q+ +D+ ++ G R K +EEL+ L + + ++ +L + + ++
Sbjct: 1041 SIALRQEQIDNQTRITKEAGSVSLRMKQVEELYHSLLELGEKRKGMLEKSCKKFMLFREA 1100
Query: 1071 DDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--- 1127
++ Q W++ + A+ SE++ L + E L ++ + ++ ++ + + + E +
Sbjct: 1101 NELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQKDLKANESRLKDINKVAEDLESE 1160
Query: 1128 ------IQGQTDPEYLLLGQR--------------------------LEGLDTGWNALGR 1155
+Q E + R ++ L+ W +L +
Sbjct: 1161 GLMAEEVQAVQQQEVYGMMPRDETDSKTASPWKSARLMVHTVATFNSIKELNERWRSLQQ 1220
Query: 1156 MWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLG 1215
+ E RS L Q F +DA + + + + L L + +A RK E F
Sbjct: 1221 LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFER 1280
Query: 1216 SMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE 1275
+ DKV S ++ +L+ ++ ++EK + ++A + L D+ +
Sbjct: 1281 DLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELNQAWSSLGKRADQRKAKLGDSHD 1340
Query: 1276 LQNFLQNCQELTLWIND-KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
LQ FL + ++L WIN + L S D + +HQ E+ + G + +
Sbjct: 1341 LQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERHQEHRTEIDARAGTFQAFEQ 1400
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
G+QL+ + + QKL+ L + +L+ ++ L L + W
Sbjct: 1401 FGQQLLAHGHYASPEIKQKLDILDQERADLEKAWVQRRMMLDQCLELQLFHRDCEQAENW 1460
Query: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
++A E L ++D G L SV ++ K + + +NV++E++ L A + G A
Sbjct: 1461 MAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIAALQAFADQLIAAGHYAKG 1520
Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKL-------QISRDLEDETLWVEERLPLAQSADYG 1507
I R ++L+ R K Q+ R+KL Q SRD+++ W+ E+L A Y
Sbjct: 1521 DISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYK 1580
Query: 1508 --TNLQTVQLFMK--KNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD--LEERLGH 1561
TN+Q +L K K+Q + E+ + R+ V+ G L+E + ++ RL
Sbjct: 1581 DPTNIQLSKLLSKHQKHQAFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAA 1640
Query: 1562 LQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIV 1621
L W L + +A + Q+L++AN+ Q + + + W+ E E + S++ KD
Sbjct: 1641 LADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNN 1700
Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEE 1681
+LK+H + + + +K L S+A L+++ + Q+ + ++ + +K +A
Sbjct: 1701 LLKKHQLLEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAAS 1760
Query: 1682 RKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGA 1741
R+ KL + L Q R+ DD E WI EK+L+ S + G+D V LR K + E A
Sbjct: 1761 RRAKLNESHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAA 1820
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ + V ++L D I + E W +L +L R Q L S + +
Sbjct: 1821 -HEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQ 1879
Query: 1802 YFYTGAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
+ E I+EK + ED G + + + H AFE + V + DV T
Sbjct: 1880 FVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFT---VHKDRVNDVCT 1936
Query: 1861 RLQTAYA--GEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSW 1918
Q E I +K + ++ L A A R+ +L + + +F A + SW
Sbjct: 1937 NGQDLIKKNNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESW 1996
Query: 1919 MESIIRQIETQERPRDVSSVELLMKYHQGINAEIET-RSKNFSACLELGESLLQRQHQAS 1977
+ ++T + RD+SSV+ L+ + +A ++ + + + L + LL +H S
Sbjct: 1997 IGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQS 2056
Query: 1978 EEIREKLQQVMSRRKEMNEKWEARWERL-------RMLLEV-CQFSRDASVAEAWLIAQE 2029
+ I + +M R ++ AR ++L R + ++ F++ AS +W E
Sbjct: 2057 KAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAE 2116
Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
L ++++ ++ L + H+AF S +S F L + ++K ++A P
Sbjct: 2117 EDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE-LDRQIKSFRVASNP 2171
Score = 280 bits (715), Expect = 1e-74
Identities = 224/998 (22%), Positives = 448/998 (44%), Gaps = 60/998 (6%)
Query: 1123 SGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEA 1182
SG KV++ D + +R + + ++ + R L FQ FQ+DA++ E
Sbjct: 4 SGVKVLETAED-----IQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEK 58
Query: 1183 ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
+ ++ +A E + ++K + F ++ N ++ ++GN +++EG+ S
Sbjct: 59 WIQ-EKLQIASDENYKDPTNLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFAS 117
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDK--LLTSQDV 1300
+ I+ ++ + + EK +E + L +L +L+ C+++ WINDK ++TS+++
Sbjct: 118 ETIRTRLMELHRQWELLLEKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEEL 177
Query: 1301 SYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRL 1360
D ++ K + F ++A+HE + ++ +L+ E+ L+ K + ++
Sbjct: 178 GQD-LEHVEVLQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAA 236
Query: 1361 WDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK 1420
W L+ ++ L A + + WI E + SDD G+DL SV +L K
Sbjct: 237 WQRLKGLALQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRK 296
Query: 1421 LKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEP-------LGRRKKQ 1473
+ +E + ++++ L A+ + + + I+ + +L+ R +
Sbjct: 297 HEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAERHAR 356
Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
L S + D D T WV E L + + +++ + + ++Q + EI H
Sbjct: 357 LNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRHQEHKGEIDAHEDS 416
Query: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
+ + GQ L+ A ++ E+L L L E R Q+ + Q +Y D
Sbjct: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCMDLQLFYRDT 476
Query: 1594 DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA 1653
++ + W+ +QE +++++++ + +LK+H ++++ I L A L+
Sbjct: 477 EQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITALDEFATKLIQN 536
Query: 1654 GHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVA 1713
H E + + + L + A R+ +L + +HL Q R++D+L+ W++EK A
Sbjct: 537 NHYAMEDVATRRDALLSRRNALHERAMRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTA 596
Query: 1714 SSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD 1773
+ E +D ++ K + F E A Q R+D + ++LID H +A +
Sbjct: 597 TD-EAYKDPSNLQGKVQKHQAFEAELSA-NQSRIDALEKAGQKLIDVNHYAKDEVAARMN 654
Query: 1774 GLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI-LGLIDEKHRELPEDVGLDASTAE 1832
+ +W LLE + + L + ++ +I L L + + +D G D + +
Sbjct: 655 EVISLWKKLLEATELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQ 714
Query: 1833 SFHRVHTAFERELHL-------LGVQVQQFQDVATRLQTAYAGE-KAEAIQNKEQEVSAA 1884
+ + H E ++ + +Q +QFQD AG AE I+ K++ + A
Sbjct: 715 NLQKKHALLEADVAAHQDRIDGITIQARQFQD---------AGHFDAENIKKKQEALVAR 765
Query: 1885 WQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKY 1944
++AL + R+ +L D+ + F D +W+ + R +D+ V+ L+K
Sbjct: 766 YEALKEPMVARKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKK 825
Query: 1945 HQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA---- 2000
HQ + AEI A + G ++++ H A+E+++ KL E+N+KWEA
Sbjct: 826 HQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLH-------ELNQKWEALKAK 878
Query: 2001 ---RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKS 2057
R + L L+ Q+ DA+ AE+W+ +EP + S D+G DS E L+K+HEA
Sbjct: 879 ASQRRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKHEALMSD 938
Query: 2058 TASWAERFAALEKPTTLELKERQIAERPAEETGPQEEE 2095
+++ AL R+ A+ ++ P ++E
Sbjct: 939 LSAYGSSIQAL----------REQAQSCRQQVAPTDDE 966
Score = 216 bits (551), Expect = 1e-55
Identities = 195/864 (22%), Positives = 366/864 (42%), Gaps = 71/864 (8%)
Query: 411 RNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF----GYDLAAVEAAKKKHEA 466
R++L + L+Q +R D E W+SE + + +++ L+ + + +KH+A
Sbjct: 1544 RSKLGESQTLQQFSRDVDEI----EAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQA 1599
Query: 467 IETDTAAYEERVRALEDLAQELEKENY--HDQKRITARKDNILRLWSYLQELLQSRRQRL 524
E + A +R+R + D+ L + + + AR + W +L + + Q+L
Sbjct: 1600 FEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQKSAEKSQKL 1659
Query: 525 ETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKV 584
+ Q + W+ E++A L S ++GK L V +LL+KH+L+EADI+ D++
Sbjct: 1660 KEANKQQNFNTGIKDFDFWLSEVEALLASEDYGKDLASVNNLLKKHQLLEADISAHEDRL 1719
Query: 585 KAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFW 644
K + + + D ++D+ + F+++ +MAA R+A+L +S RL +FF
Sbjct: 1720 KDLNSQADSLMTSSAF---DTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRLHQFFR 1776
Query: 645 EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
+MD+ ESWIKEK+ + S DYG+DLT V L++KHK E EL + ++ + +
Sbjct: 1777 DMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEAELAAHEPAIQGVLDTGKKLS 1836
Query: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHR 764
G +I+ R+ + W +LK LAA + L+++ + QF + ++ +AW+ +
Sbjct: 1837 DDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEEEAWINEKMT 1896
Query: 765 LLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG-FPEEFRDSPDVTHRL 823
L++ ED G A + L KKH+ F + + + + Q + +++ ++
Sbjct: 1897 LVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQDLIKKNNHHEENISSKM 1956
Query: 824 QALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDL 883
+ L + A R+ +L E + D E W+GEKE L + L +
Sbjct: 1957 KGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWKADVVESWIGEKENSLKTDDYGRDLSSV 2016
Query: 884 EVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTL 942
+ + + + D ++ + I + + L+ + H +S+ ++ L RW
Sbjct: 2017 QTLLTKQETFDAGLQAFQQEGIANITALKDQLLAAKHVQSKAIEARHASLMKRWSQLLAN 2076
Query: 943 VSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES-----TKDLG-----RDLAGIIA 992
+ R++ + L ++ E+ K S +DL L I A
Sbjct: 2077 SAARKKKL---LEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKA 2133
Query: 993 IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQ---- 1048
++ +++ QA + L +Q+ + LEE W+ LQ+
Sbjct: 2134 LREAHDAFRSSLSSAQADFNQLAELDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKE 2193
Query: 1049 ---SLQGQEDLLGEVSQL-QAFLQDLDDFQAWLSITQKAVASED-MPESLPEAEQLLQQH 1103
LQ ++ E +L Q F Q + F W+ T+ + M E E L+
Sbjct: 2194 RELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEAT 2253
Query: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLE-----GLDTGWNALGRMWE 1158
EI + +++++ G + E L+L + GL W+ L ++
Sbjct: 2254 KRKHQEIRAMRSQLKKIEDLGAAM------EEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
Query: 1159 SRSHTLAQ------------------CLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSL 1200
H L Q + F+ F KD L++QE+ L
Sbjct: 2308 RMQHNLEQQIQARNTTGVTEEALKEFSMMFKHFDKD---KSGRLNHQEFKSCLRSLGYDL 2364
Query: 1201 EAAEAG--IRKFEDFLGSMENNRD 1222
E G +FE L +++ NRD
Sbjct: 2365 PMVEEGEPDPEFEAILDTVDPNRD 2388
Score = 57.0 bits (136), Expect = 2e-07
Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 15/247 (6%)
Query: 284 AVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQA 343
A K++ + H + E + ++ AS +W E L NSL ++ +A
Sbjct: 2078 AARKKKLLEAQSHFRKVEDLFLTFAKKASAFNSWFENAEEDLTDPVRCNSLEEIKALREA 2137
Query: 344 FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
+R+ + + L L I+S A+N P+ + + W +L++
Sbjct: 2138 HDAFRSSLSSAQ-ADFNQLAELDRQIKSFRVASN-----PYTWFTMEALEETWRNLQKII 2191
Query: 404 YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-----DNFGYDLAAVE 458
REL L+ E RQE+ ++L + F + A W+ E + + + G + +E
Sbjct: 2192 KERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLE 2251
Query: 459 AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
A K+KH+ I A +++ +EDL +E+ D K + + W L +L
Sbjct: 2252 ATKRKHQEIR----AMRSQLKKIEDLGAAMEEALILDNKYTEHSTVGLAQQWDQLDQLGM 2307
Query: 519 SRRQRLE 525
+ LE
Sbjct: 2308 RMQHNLE 2314
Score = 45.1 bits (105), Expect = 8e-04
Identities = 75/396 (18%), Positives = 152/396 (38%), Gaps = 38/396 (9%)
Query: 316 TWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKG--NLEVLLFTIQSRM 373
+WI + L + + L+ VQ L T+ + FQ++G N+ L + +
Sbjct: 1995 SWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQA--FQQEGIANITALKDQLLAAK 2052
Query: 374 RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAM 433
++ + H + + + W L R+ L K+E L F +KA+
Sbjct: 2053 HVQSKAIEARH-----ASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAKKASA 2107
Query: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
+W + + L ++A ++ H+A + ++ + L +L ++++
Sbjct: 2108 FNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIKSFRV 2167
Query: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQ----KLFQDMLHSID----WMD 545
+ + W LQ++++ R L+ Q KL Q+ + W+
Sbjct: 2168 ASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQHANAFHQWIQ 2227
Query: 546 EIKAHLLSA-----EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGY 600
E + +LL E G ++E +KH+ + A + Q K++ + AA +
Sbjct: 2228 ETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRA-MRSQLKKIEDLGAAM------EEA 2280
Query: 601 QPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIY 660
D + + L Q +++L + + LEQ + +EA +KE ++
Sbjct: 2281 LILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEA---LKEFSMMF 2337
Query: 661 SSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQI 696
D KD + L H+ F+ LR L L +
Sbjct: 2338 KHFD--KDKSGRL----NHQEFKSCLRSLGYDLPMV 2367
>gi|115298659 spectrin, alpha, erythrocytic 1 [Homo sapiens]
Length = 2419
Score = 513 bits (1321), Expect = e-145
Identities = 384/1449 (26%), Positives = 674/1449 (46%), Gaps = 109/1449 (7%)
Query: 713 QIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVG 772
+I+ R +EV ++ K+ A + L+D+ + F+ DADDL W+ + +L+ +
Sbjct: 23 EIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKSY- 81
Query: 773 QDEGATRALGK--KHKDFLEELEESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALREL 829
E T GK KH+ E++ +M LE+ + + F + ++ LR L
Sbjct: 82 --EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHL 139
Query: 830 YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHR 889
+ ++ + +L AL E W+G+KE +E+ + E EV+ +
Sbjct: 140 WDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKK 199
Query: 890 FDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREA 949
F+ E+ ++ VN AN E HP ++ Q+ +N W+ + L +R++A
Sbjct: 200 FEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGLALQRQKA 259
Query: 950 VDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ +A + + D E +WI +K V+ S +D G+DL + GLER++A +
Sbjct: 260 LSNAANLQRFKRDVTEAIQWIKEKEPVLTS-EDYGKDLVASEGLFHSHKGLERNLAVMSD 318
Query: 1010 RVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQD 1069
+V L ++++L SHP I + ++ L W+ ++ + + L F D
Sbjct: 319 KVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRFSSD 378
Query: 1070 LDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ 1129
D+ W++ A+ ++++P + E LL +H K EID + D +Q E+G+ ++
Sbjct: 379 FDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQDLVN 438
Query: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEY 1189
+ + +++E LD W AL +W+ R QCL F F +D++Q ++ +S QE
Sbjct: 439 ANHEASDEVR-EKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSWMSRQEA 497
Query: 1190 TLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
L + + +SL +AEA ++K EDF + +K+++ + KL+ + + S+ IK
Sbjct: 498 FLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDSENIKAIR 557
Query: 1250 QLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLH 1309
+ R EKA LL+++L LQ ++ +L WIN K + D Y + +NL
Sbjct: 558 DGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKDIQNLK 617
Query: 1310 NKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTK 1369
++ K Q F ELA ++ LENI G+++++ + V+ +L + LW+EL TK
Sbjct: 618 SRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLWEELLEATK 677
Query: 1370 EKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV 1428
+K L A + L+ + +A DL +W+ +E Q+ S+D GK L V L K +E V
Sbjct: 678 QKGTQLHEA-NQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAV 736
Query: 1429 NVRKEELGELFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLGRRKKQLESSRAK 1480
R++++ ++ + + EE G D S+ RF L EPL RKK+L
Sbjct: 737 AARQDQV-DILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKLLDLLHL 795
Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
I RD EDE W++E P A S G +L + + +++ + I H PR++++ +R
Sbjct: 796 QLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEITER 855
Query: 1541 GQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRL----------QRLRDANEAQ--- 1587
G ++VE +D+ R+ L + + LR AA R Q L D +EA+
Sbjct: 856 GNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAETWI 915
Query: 1588 ----------QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYG 1637
Y D + A A + + E +++ D A+ +QQ+A G
Sbjct: 916 REKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEG 975
Query: 1638 ------------------RNI-------------------KQLASRAQGLLSAGH----- 1655
R + K A+ QG++ A +
Sbjct: 976 VAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
Query: 1656 ------------PEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLE 1703
E I + Q Q++ Y L D AEER+R+L Y+ F L E D+
Sbjct: 1036 HDEFPMLPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDML 1095
Query: 1704 QWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAG-- 1761
+WI EK+ + G + D V L+ KF +F ++ + R+ ++N + L+ G
Sbjct: 1096 EWIQEKK----AENTGVELDDVWELQKKFDEFQKDLNT-NEPRLRDINKVADDLLFEGLL 1150
Query: 1762 HSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELP 1821
E A I + LN W L L D + QLL +++ + + + I++K + L
Sbjct: 1151 TPEGAQI---RQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALS 1207
Query: 1822 E-DVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQE 1880
D G D + ++ R H FER+L LG +V + A RL ++ + E +Q ++ E
Sbjct: 1208 AADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHP-DATEDLQRQKME 1266
Query: 1881 VSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVEL 1940
++ AW+ L R+ L + + F S ARDL +W+ SI + +QE D++ +E+
Sbjct: 1267 LNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEI 1326
Query: 1941 LMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA 2000
L++ HQ A++E + F A + L+ H AS EI +KLQ V R ++ + WE
Sbjct: 1327 LLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEK 1386
Query: 2001 RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
R + L LE+ F + E+W++A+E L S D ++DS+E L+K+ + +K+ +
Sbjct: 1387 RKKILDQCLELQMFQGNCDQVESWMVARENSLRSDD-KSSLDSLEALMKKRDDLDKAITA 1445
Query: 2061 WAERFAALE 2069
+ LE
Sbjct: 1446 QEGKITDLE 1454
Score = 471 bits (1211), Expect = e-132
Identities = 357/1423 (25%), Positives = 669/1423 (47%), Gaps = 71/1423 (4%)
Query: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
+S++ WE L EA ++ L E +QL +F+ A + WL + + V +
Sbjct: 662 LSEVASLWEELLEATKQKGTQLH------EANQQL--QFENNAEDLQRWLEDVEWQVTSE 713
Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
++G LA V+ +KH +E+ AA +++V L DLA E+ + D K I AR+++++
Sbjct: 714 DYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVC 773
Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
+ L+E L +R+++L L LQ + +D W+ E + S GK L+ + LL
Sbjct: 774 RFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLN 833
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
+H+++ +IA +++ IT K E + D + R+ L Q E L AA
Sbjct: 834 RHRVILENIASHEPRIQEITERGNKMVEEGHFAAED---VASRVKSLNQNMESLRARAAR 890
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
R+ LE + + ++ ++ EAE+WI+EKE I + +YG D + L +KH+AF +L
Sbjct: 891 RQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNS 950
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
++ + +A+ Q A ++ V+ + Q + F
Sbjct: 951 FGDSMKALRNQANAC-------QQQQAAPVEGVAGE---------------QRVMALYDF 988
Query: 749 QGDAD-DLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQ 807
Q + ++ D LLS + +D A H+ + + R +
Sbjct: 989 QARSPREVTMKKGDVLTLLSS--INKDWWKVEAAD--HQGIVPAVYVRRLAHDEFPM--- 1041
Query: 808 GFPEEFRDSP-DVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
P+ R+ P ++T R + + Y+ ++ +A+ R++RL + + + + E W+ E
Sbjct: 1042 -LPQRRREEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQE 1100
Query: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG--HPRSRE 924
K+ +E+ D E +Q +FD +++ T ++ +N A+ L+ G P +
Sbjct: 1101 KKAENTGVELDDVWE----LQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQ 1156
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
++Q LN+RW + Q L E+R+ + SA V + + ++T + I K + + S D G
Sbjct: 1157 IRQ---ELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQAL-SAADPG 1212
Query: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ 1044
DL + A+QR+ G ERD+ + +V L +++L +SHP+ ED+ +++ L E W+
Sbjct: 1213 SDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWE 1272
Query: 1045 GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA 1104
LQ + +++ L E + FL D Q W+S V+S+++ E L E LL++H
Sbjct: 1273 DLQGRTKDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQ 1332
Query: 1105 GIKDEIDGHQDSYQRVKESGEKVIQG--QTDPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162
+ +++ ++Q +++ ++I PE + ++L+ + + L + WE R
Sbjct: 1333 EHRADMEAEAPTFQALEDFSAELIDSGHHASPE---IEKKLQAVKLERDDLEKAWEKRKK 1389
Query: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222
L QCL Q FQ + Q E+ + +E +L + SL++ EA ++K +D ++
Sbjct: 1390 ILDQCLELQMFQGNCDQVESWMVARENSLRS-DDKSSLDSLEALMKKRDDLDKAITAQEG 1448
Query: 1223 KVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQN 1282
K+ L+A+ + ++I ++Q + DR + + + L D L+ F ++
Sbjct: 1449 KITDLEHFAESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRD 1508
Query: 1283 CQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE 1342
+EL WI++ L T+ D SY +A N+ K+LKHQ F E+ + + G L++
Sbjct: 1509 LEELEEWISEMLPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIEC 1568
Query: 1343 KP--QFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
+ ++LE L WD L T +K + L+ A + D W+S E
Sbjct: 1569 SACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAET 1628
Query: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE---ELGELFAQVPSMGEEGGDADL--- 1454
L D +DL S +L K + +E ++ R++ +L L + S G D +
Sbjct: 1629 LLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKK 1688
Query: 1455 -SIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTV 1513
++ KRFL++ E ++L+ + A Q +DL+DE W+EE+L S DYG +LQ V
Sbjct: 1689 DNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGV 1748
Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAA 1573
Q +KK++ L+ E++ H P +++VL ++L + A + ++++ RL W++L+E A
Sbjct: 1749 QNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELA 1808
Query: 1574 AGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAV 1633
R +L ++ E Q+ +A+E EAWI E+ + + +L +H +
Sbjct: 1809 KARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDF 1868
Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDVAEERKRKLENMY 1690
+ ++ + ++ + +L+ E Q + +++ + L K +LE+ Y
Sbjct: 1869 AVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDY 1928
Query: 1691 HLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNV 1750
+ + D +E WI++KE + G D L K + QER+ +
Sbjct: 1929 AFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEI 1988
Query: 1751 NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL 1793
++LI A H+++ I E L + W LLE Q L
Sbjct: 1989 TDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKL 2031
Score = 367 bits (942), Expect = e-101
Identities = 373/1695 (22%), Positives = 735/1695 (43%), Gaps = 90/1695 (5%)
Query: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
+++N AWE L +R+ AL N Q RF R W+ E + ++ ++
Sbjct: 240 NEVNAAWERLRGLALQRQKALSNAANLQ--------RFKRDVTEAIQWIKEKEPVLTSED 291
Query: 450 FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRL 509
+G DL A E H+ +E + A ++V+ L A++L + D +I K++++
Sbjct: 292 YGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSS 351
Query: 510 WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQK 569
W +++ L SR ++L+ T + D WM+E A + + E + E LL +
Sbjct: 352 WEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDR 411
Query: 570 HKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
H+ + +I D+ ++ ++ D +++++ L+ + L + R
Sbjct: 412 HQQHKHEIDSYDDRFQSADETGQDLVNAN-HEASDE--VREKMEILDNNWTALLELWDER 468
Query: 630 KAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGL 689
Q EQ F+ + ++ +SW+ +E + D G L S L +KH+ FE+
Sbjct: 469 HRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQ 528
Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQ 749
+ + + + A ++ + I+A + A+ D L++ AA ++ L+++ +
Sbjct: 529 EEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLY 588
Query: 750 GDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
D+DDLK W+ +L ED +D ++ +K + F +EL ++ +E++++ Q
Sbjct: 589 EDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEM 647
Query: 810 PEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKE 868
E + D VT RL + L+++++ + +L EA E +A +L +
Sbjct: 648 IEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQF--ENNAEDL-----Q 700
Query: 869 KWLAEMEMPDTLED----LEVVQHRF---DILDQEMKTLMTQIDGVNLAANSLVESGHPR 921
+WL ++E T ED L VQ+R +L+ + Q+D + A E GHP
Sbjct: 701 RWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPD 760
Query: 922 SREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTK 981
S++++ Q+ L R++A + ++ R++ + L + C D E+ WI + ST
Sbjct: 761 SKDIRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTY 820
Query: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEE 1041
LG+DL + + + ++A+ + R+ + ++++ ED+ R K L +
Sbjct: 821 -LGKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQ 879
Query: 1042 LWQGLQ-QSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLL 1100
+ L+ ++ + Q DL V Q Q +L DL + + W+ + V + + A LL
Sbjct: 880 NMESLRARAARRQNDLEANV-QFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALL 938
Query: 1101 QQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESR 1160
++H +++ DS + ++ Q Q P + G++
Sbjct: 939 KKHEAFLLDLNSFGDSMKALRNQANACQQQQAAPVEGVAGEQ------------------ 980
Query: 1161 SHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
+ + +FQ + + + TL D + A + +
Sbjct: 981 -----RVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLA 1035
Query: 1221 RDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFL 1280
D+ P+ + GN I ++ + IE+++R ++A+E L
Sbjct: 1036 HDEF--PMLPQRRREEPGN-----ITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLA 1088
Query: 1281 QNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM 1340
++ WI +K + V D+ L K+ F +L ++E L +I+ L+
Sbjct: 1089 YEAGDMLEWIQEKKAENTGVELDDVWELQKKF---DEFQKDLNTNEPRLRDINKVADDLL 1145
Query: 1341 DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMED 1400
E T +Q + L+ W LQ E+ Q L +A + ++ + D + I
Sbjct: 1146 FEG-LLTPEGAQIRQELNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQ 1204
Query: 1401 QLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRF 1460
L + DPG DL SV + + + E + +++ L + E DA ++++
Sbjct: 1205 ALSAADPGSDLFSVQALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQK 1264
Query: 1461 LDLLEPL----GRRKKQLESSRAK------LQISRDLEDETLWVEERLPLAQSADYGTNL 1510
++L E GR K + ES L +RDL++ W+ + S + +L
Sbjct: 1265 MELNEAWEDLQGRTKDRKESLNEAQKFYLFLSKARDLQN---WISSIGGMVSSQELAEDL 1321
Query: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570
+++ ++++Q + ++ P + + +L+++ ++E++L ++ D L
Sbjct: 1322 TGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLE 1381
Query: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
+A R + L E Q + + D+ E+W+ +E + SD+ + +M KR +
Sbjct: 1382 KAWEKRKKILDQCLELQMFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKRDDLDK 1441
Query: 1631 RAVEDYGRNIKQLASRAQGLLSAGHPEGEQII-RLQGQVDKHYAGLKDVAEERKRKLENM 1689
G+ I L A+ L++ H E+I RLQ +D+ + LK + + KL +
Sbjct: 1442 AITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVLDR-WKALKAQLIDERTKLGDY 1499
Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
+L Q R+ ++LE+WISE L + E +D ++ K + FA E E+V
Sbjct: 1500 ANLKQFYRDLEELEEWISEM-LPTACDESYKDATNIQRKYLKHQTFAHEVDG-RSEQVHG 1557
Query: 1750 V----NAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYT 1805
V N+ IE G+ EA + E + L E W LLE + + + L + R+ +
Sbjct: 1558 VINLGNSLIECSACDGNEEA--MKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTS 1615
Query: 1806 GAEILGLIDEKHRELP-EDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT 1864
+ + E L +D D ++A + + H ERE+ ++ +A L +
Sbjct: 1616 IRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLS 1675
Query: 1865 AYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIR 1924
+ + I K+ V+ + + + A +L + F+FF D SW+E +
Sbjct: 1676 S-GTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLI 1734
Query: 1925 QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKL 1984
++ +Q+ RD+ V+ L+K H+ + E+ L++ E L + EEI+ +L
Sbjct: 1735 RVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRL 1794
Query: 1985 QQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSV 2044
Q + +++ E +AR +L LE QF ++A EAW+ + GD G T+ +
Sbjct: 1795 AQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAAT 1854
Query: 2045 EKLIKRHEAFEKSTA 2059
+ L+ +HEA E A
Sbjct: 1855 QSLLMKHEALENDFA 1869
Score = 362 bits (929), Expect = 2e-99
Identities = 341/1698 (20%), Positives = 712/1698 (41%), Gaps = 72/1698 (4%)
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---------FDRKAAM 433
P + + S + E+ EE + RR+ L +E++ + ++ F R A
Sbjct: 5 PKETVVESSGPKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
Query: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
W+ E ++ ++ D ++ +KH+++E + + LE +E +
Sbjct: 65 LGKWIMEKVNILTDKSYE-DPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGH 123
Query: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
+ A + + LW L EL + +L L Q+ Q+ ++W+ + +A S
Sbjct: 124 SAHEETKAHIEELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATS 183
Query: 554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
E G+ E L +K + + ++ + +V + + E P D +IQ + +
Sbjct: 184 VELGEDWERTEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEEN--HP-DLPLIQSKQN 240
Query: 614 HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
+ +E L +A R+ L + L +F ++ EA WIKEKE + +S DYGKDL +
Sbjct: 241 EVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASE 300
Query: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
L HK E L + ++++ +A + PQI+ +++ + W+ ++ LA
Sbjct: 301 GLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALAT 360
Query: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
+ LQ + +F D D+L W+ + ++ +++ D L +H+ E++
Sbjct: 361 SRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEID 420
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
+ ++ Q ++ D V +++ L + ++ D R ++ ++ LD +
Sbjct: 421 SYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHL 480
Query: 853 VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
+ +++ + WM +E +L ++ ++L E + + + ++ +I V+ A
Sbjct: 481 FYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTAT 540
Query: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
L+ H S +K +D L R A + + RR + +L + D ++ WI
Sbjct: 541 KLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINK 600
Query: 973 KTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
K K+ + + +D+ + + +K E+++A + +++ +++ Q++++ +++
Sbjct: 601 KKKLADD--EDYKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNV 658
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPES 1092
R + LW+ L ++ + + L E +Q F + +D Q WL + V SED +
Sbjct: 659 TTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKG 718
Query: 1093 LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNA 1152
L E + L++H ++ + QD + + + P+ + R E L + A
Sbjct: 719 LAEVQNRLRKHGLLESAVAARQDQVDILTDLA-AYFEEIGHPDSKDIRARQESLVCRFEA 777
Query: 1153 LGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFED 1212
L +R L L Q +D + EA + E + L A++ + +
Sbjct: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
Query: 1213 FLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRD 1272
L ++ ++ ++ + GNK+V EG+ ++ + +V+ + +A L
Sbjct: 838 ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897
Query: 1273 NLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENI 1332
N++ Q +L + E WI +K + +Y +A A L HE +L ++
Sbjct: 898 NVQFQQYLADLHEAETWIREKEPIVDNTNYG---------ADEEAAGALLKKHEAFLLDL 948
Query: 1333 DAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLN 1392
++ G + + Q A Q+ + + E Q + A R
Sbjct: 949 NSFGDSMKALRNQANACQQQQAAPVEGVAGE---------QRVMALYDFQAR-------- 991
Query: 1393 KWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQ-----VNVRKEELGELFAQVPSMGE 1447
S E ++ D L+S+N+ K++ + Q V VR+ E E
Sbjct: 992 ---SPREVTMKKGDVLTLLSSINKDWWKVEAADHQGIVPAVYVRRLAHDEFPMLPQRRRE 1048
Query: 1448 EGGD---ADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSA 1504
E G+ IE ++ LL+ R+++L + ++ + D W++E+ ++
Sbjct: 1049 EPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAE 1104
Query: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQS 1564
+ G L V KK Q ++ + PR+ D+ + L+ + + + R L S
Sbjct: 1105 NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIR-QELNS 1163
Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVML- 1623
W L+ A + Q L A+ + ++ +AD+ + I E++ +S P + ++ L
Sbjct: 1164 RWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQI-EKKCQALSAADPGSDLFSVQALQ 1222
Query: 1624 KRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-EQIIRLQGQVDKHYAGLKDVAEER 1682
+RH +R + G + L A+ LS HP+ E + R + ++++ + L+ ++R
Sbjct: 1223 RRHEGFERDLVPLGDKVTILGETAE-RLSESHPDATEDLQRQKMELNEAWEDLQGRTKDR 1281
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAI 1742
K L + + DL+ WIS + SS E+ +D + +L ++ ++ + A
Sbjct: 1282 KESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEA- 1340
Query: 1743 GQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRY 1802
+ F LID+GH + I + + DL + + R ++L +L +
Sbjct: 1341 EAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMF 1400
Query: 1803 FYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRL 1862
++ + + L D D S+ +S + + + Q + D+
Sbjct: 1401 QGNCDQVESWMVARENSLRSD---DKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA 1457
Query: 1863 QTAYAGE--KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWME 1920
++ A E E I + Q V W+AL RT+L D A+ +F+ +L W+
Sbjct: 1458 ESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
Query: 1921 SIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ--HQASE 1978
++ E +D ++++ HQ E++ RS+ + LG SL++ E
Sbjct: 1518 EML-PTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576
Query: 1979 EIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
++E+L+Q+ + E+ + ++L +F+ E WL E LA D
Sbjct: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636
Query: 2039 HTVDSVEKLIKRHEAFEK 2056
+ S L+K+H+ E+
Sbjct: 1637 RDLASAGNLLKKHQLLER 1654
Score = 328 bits (842), Expect = 3e-89
Identities = 370/1832 (20%), Positives = 733/1832 (40%), Gaps = 117/1832 (6%)
Query: 297 AIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKF 356
A+ ++++ ++ + WI++ VL S + L + F +++ +E+
Sbjct: 259 ALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEG---LFHSHKGLER---- 311
Query: 357 QEKGNLEVLLFTIQSRM-RANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI 415
NL V+ ++ +A + P D + ++ + + E+ R LA
Sbjct: 312 ----NLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE--DLVSSWEHIRALATS---- 361
Query: 416 RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAA 473
R EKL+ RF W++E + D D+A E +H+ + + +
Sbjct: 362 RYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDS 421
Query: 474 YEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
Y++R ++ ++ Q+L N+ + + + + W+ L EL R ++ E L
Sbjct: 422 YDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLF 481
Query: 534 FQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLK 593
++D WM +A L + + G L E LLQKH+ E Q +K+ + K
Sbjct: 482 YRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATK 541
Query: 594 FTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWI 653
Y + + I+D + E AA R+ L++S L K + + D+ ++WI
Sbjct: 542 LIGDDHYDSENIKAIRDGLLARRDALRE---KAATRRRLLKESLLLQKLYEDSDDLKNWI 598
Query: 654 KEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQ 713
+K+++ DY KD+ ++ +K + FE EL LE I + M+ +
Sbjct: 599 NKKKKLADDEDY-KDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN 657
Query: 714 IEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQ 773
+ R+ EV++ W++L + L +A QF+ +A+DL+ WL+D ++ ED G+
Sbjct: 658 VTTRLSEVASLWEELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGK 717
Query: 774 DEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE-EFRDSPDVTHRLQALRELYQQ 832
+ +KH + + ++ L A F E DS D+ R ++L ++
Sbjct: 718 GLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEA 777
Query: 833 VVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDI 892
+ R+++L + L L + +T+ E W+ E E + L + + +R +
Sbjct: 778 LKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRV 837
Query: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDS 952
+ + + + +I + N +VE GH + +V LN ++ + + R+ +++
Sbjct: 838 ILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEA 897
Query: 953 ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
++ Y D E WI +K +V++T + G D A+ +K D+ + +
Sbjct: 898 NVQFQQYLADLHEAETWIREKEPIVDNT-NYGADEEAAGALLKKHEAFLLDLNSFGDSMK 956
Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD 1072
AL ++ E + Q+ + L+ +S + G+V L + +
Sbjct: 957 ALRNQANACQQQQAAPVEGVAGEQRVMA-LYDFQARSPREVTMKKGDVLTLLSSIN---- 1011
Query: 1073 FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQT 1132
+ W + H GI + +R+ ++ +
Sbjct: 1012 -KDWWKVEAA-------------------DHQGIVPAV-----YVRRLAHDEFPMLPQRR 1046
Query: 1133 DPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLA 1192
E + QR E ++ + +L E R L Q + EF + + + QE
Sbjct: 1047 REEPGNITQRQEQIENQYRSLLDRAEERRRRLLQ--RYNEFLLAYEAGDMLEWIQEKKAE 1104
Query: 1193 H--LEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQ 1250
+ +E D E +KF++F + N ++ + L+ EG L + + + +
Sbjct: 1105 NTGVELDDVWELQ----KKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160
Query: 1251 LIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL--LTSQDVSYDEARNL 1308
L R A E LL ++ F + + I K L++ D D ++
Sbjct: 1161 L-NSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSD-LFSV 1218
Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATT 1368
+H+ F +L + + ++L + P T + ++ L+ W++LQ T
Sbjct: 1219 QALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRT 1278
Query: 1369 KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV 1428
K++ + L+ A+ L L DL WIS++ + S + +DLT + +L + + +
Sbjct: 1279 KDRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADM 1338
Query: 1429 NVRKEELGELFAQVPSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKL 1481
L + + G A IEK+ DL + +RKK L+
Sbjct: 1339 EAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQ 1398
Query: 1482 QISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRG 1541
+ + W+ R +S D ++L +++ MKK L I ++ D+
Sbjct: 1399 MFQGNCDQVESWMVARENSLRSDDK-SSLDSLEALMKKRDDLDKAITAQEGKITDLEHFA 1457
Query: 1542 QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIG 1601
+ L+ +++ RL + W L+ +L D +Q+Y D +E E WI
Sbjct: 1458 ESLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWIS 1517
Query: 1602 EQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-EQ 1660
E L DE KD +H V+ + + + L+ +G E+
Sbjct: 1518 EM-LPTACDESYKDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEE 1576
Query: 1661 IIRLQ-GQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMG 1719
++ Q Q+ +H+ L + ++ +KL + D E W+SE E + + +
Sbjct: 1577 AMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQA 1636
Query: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMW 1779
+D L K + RE A ++ + ++N E L+ +G I + KD +N+ +
Sbjct: 1637 RDLASAGNLLKKHQLLEREMLA-REDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF 1695
Query: 1780 ADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKH-RELPEDVGLDASTAESFHRVH 1838
++ EL + L +Y L ++F + I+EK R +D G D ++ + H
Sbjct: 1696 LNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKH 1755
Query: 1839 TAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQ 1898
E EL +Q D+A +L+ A E IQ + + W+ L + R +
Sbjct: 1756 KRLEGELVAHEPAIQNVLDMAEKLKDK-AAVGQEEIQLRLAQFVEHWEKLKELAKARGLK 1814
Query: 1899 LVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI---ETR 1955
L ++ + +F A + +W+ + +++ + L+ H+ + + ETR
Sbjct: 1815 LEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETR 1874
Query: 1956 SKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVC--- 2012
+N A E+I K+ Q S+ KE++ K EA E+ L +
Sbjct: 1875 VQNVCA--------------QGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAW 1920
Query: 2013 -----------QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
+F+ A V EAW+ +E L + G + L+ + + + S S+
Sbjct: 1921 KLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQSF 1980
Query: 2062 AERFAALEKPTTLELKERQIAERPAEETGPQE 2093
+ P +LK++ I+ + + +E
Sbjct: 1981 QQE----RLPEITDLKDKLISAQHNQSKAIEE 2008
Score = 270 bits (689), Expect = 1e-71
Identities = 197/857 (22%), Positives = 385/857 (44%), Gaps = 27/857 (3%)
Query: 1242 SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS 1301
+++I+E+ Q + R++ E+ E L D+ LQ F ++ +L WI +K+ D S
Sbjct: 21 AEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVNILTDKS 80
Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLW 1361
Y++ N+ K+ KHQ+ AE+ + + ++ ++ +E L LW
Sbjct: 81 YEDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHIEELRHLW 140
Query: 1362 DELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVN------ 1415
D L T EK L A +Q AD+ +WI E S + G+D
Sbjct: 141 DLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSVELGEDWERTEVLHKKF 200
Query: 1416 -----RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470
++AK RV + E E +P + + + + + E+ L L +
Sbjct: 201 EDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWER-----LRGLALQ 255
Query: 1471 KKQLESSRAKLQ-ISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
+++ S+ A LQ RD+ + W++E+ P+ S DYG +L + ++ L+ +
Sbjct: 256 RQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERNLAV 315
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQY 1589
+ +V+++ + ++L + D ++E L SSW+ +R A R ++L+ ++
Sbjct: 316 MSDKVKELCAKAEKLTLSHPSDAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYWYHRF 375
Query: 1590 YLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQG 1649
D DE W+ E+ + +DE+P D G V+L RH + + ++ Y + Q
Sbjct: 376 SSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADETGQD 435
Query: 1650 LLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM--YHLFQLKRETDDLEQWIS 1707
L++A H +++ +D ++ L ++ +ER R+ E +HLF R+++ ++ W+S
Sbjct: 436 LVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFY--RDSEQVDSWMS 493
Query: 1708 EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT 1767
+E + ++G L K DF E +E++ V+ +LI H ++
Sbjct: 494 RQEAFLENEDLGNSLGSAEALLQKHEDF-EEAFTAQEEKIITVDKTATKLIGDDHYDSEN 552
Query: 1768 IAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLD 1827
I +DGL L E TR +LL S L + + ++ I++K + ++ D
Sbjct: 553 IKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKKKLADDEDYKD 612
Query: 1828 ASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA--YAGEKAEAIQNKEQEVSAAW 1885
+S + FE+EL + Q++ Q + YA + + + EV++ W
Sbjct: 613 IQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDN---VTTRLSEVASLW 669
Query: 1886 QALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYH 1945
+ LL+A + TQL + + +F + A DL W+E + Q+ +++ + ++ V+ ++ H
Sbjct: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
Query: 1946 QGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERL 2005
+ + + R +L + H S++IR + + ++ R + + E R ++L
Sbjct: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
Query: 2006 RMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERF 2065
LL + RD EAW+ EP S G + + +KL+ RH ++ AS R
Sbjct: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
Query: 2066 AALEKPTTLELKERQIA 2082
+ + ++E A
Sbjct: 850 QEITERGNKMVEEGHFA 866
Score = 244 bits (623), Expect = 7e-64
Identities = 285/1461 (19%), Positives = 593/1461 (40%), Gaps = 94/1461 (6%)
Query: 306 KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
++ A DL W+E + S + L VQ +L+ + + Q
Sbjct: 691 QFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQ-------- 742
Query: 366 LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELI-RQEKLEQLA 424
I + + A +++ P D K DI ESL R AL+ L R++KL L
Sbjct: 743 -VDILTDLAAYFEEIGHP-DSK---DIRARQESL----VCRFEALKEPLATRKKKLLDLL 793
Query: 425 --RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALE 482
+ R E W+ E + G DL A + +H I + A++E R++ +
Sbjct: 794 HLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRIQEIT 853
Query: 483 DLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSID 542
+ ++ +E + + + +R ++ + L+ R+ LE + Q+ D+ +
Sbjct: 854 ERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLHEAET 913
Query: 543 WMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQP 602
W+ E + + + +G LL+KH+ D+ GD +KA+ + + P
Sbjct: 914 WIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFGDSMKALRNQANACQQQQA-AP 972
Query: 603 CDPQVIQDRISHLEQCFEELSNMAAGRKAQ-LEQSKRLWKFFWEMDEAESWIKEKEQIYS 661
+ + R+ L +K L + K +W+++ A
Sbjct: 973 VEGVAGEQRVMALYDFQARSPREVTMKKGDVLTLLSSINKDWWKVEAA------------ 1020
Query: 662 SLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEV 721
D+ + +V + + H F L Q +E G + ++Q +++
Sbjct: 1021 --DHQGIVPAVYVRRLAHDEFP--------MLPQRRREEPGNITQRQ----------EQI 1060
Query: 722 SAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRAL 781
Q+ L D A ++ L N F +A D+ W+Q+ E+ G + L
Sbjct: 1061 ENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEK----KAENTGVELDDVWEL 1116
Query: 782 GKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQ 841
KK +F ++L + + + + A E +P+ Q L + + AD ++
Sbjct: 1117 QKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQELNSRWGSLQRLADEQR 1176
Query: 842 QRLQEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLM 901
Q L A + E D + + +K + L+ + L ++ +Q R + ++++ L
Sbjct: 1177 QLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQALQRRHEGFERDLVPLG 1236
Query: 902 TQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCV 961
++ + A L ES + ++++ + LN W+ Q +R+E+++ A + + +
Sbjct: 1237 DKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTKDRKESLNEAQKFYLFLS 1296
Query: 962 DCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL 1021
+ WI+ +V S+++L DL GI + + D+ A ALE S +L
Sbjct: 1297 KARDLQNWISSIGGMV-SSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL 1355
Query: 1022 MDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ 1081
+DS +I ++ + ++ L+++ + ++ +L + +LQ F + D ++W+ +
Sbjct: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVARE 1415
Query: 1082 KAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLL--L 1139
++ S+D SL E L+++ + I + ++ E +I D Y +
Sbjct: 1416 NSLRSDD-KSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAESLI---ADEHYAKEEI 1471
Query: 1140 GQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS 1199
RL+ + W AL L ++F +D ++ E +S T D+
Sbjct: 1472 ATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYKDA 1531
Query: 1200 LEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLV----AEGNLYSDKIKEKVQLIEDR 1255
+ K + F ++ ++V ++ GN L+ +GN + +KE+++ +++
Sbjct: 1532 TNIQRKYL-KHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGN--EEAMKEQLEQLKEH 1588
Query: 1256 HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWIN--DKLLTSQDVSYDEARNLHNKWL 1313
E+ + L + Q F + ++ W++ + LL +D + D A + N
Sbjct: 1589 WDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLA-SAGNLLK 1647
Query: 1314 KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ 1373
KHQ E+ + E L++++ + L+ + +K + +++ + +Q +
Sbjct: 1648 KHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHE 1707
Query: 1374 HLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE 1433
L A + Q D WI ++ S D G+DL V +L K KR+E ++ +
Sbjct: 1708 KLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEP 1767
Query: 1434 ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKK-------QLESSRAKLQISRD 1486
+ + + ++ I+ R +E + K+ +LE S LQ ++
Sbjct: 1768 AIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQN 1827
Query: 1487 LEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVE 1546
E+E W+ E+ LA D G L Q + K++ L+N+ H RV++V +G+ ++
Sbjct: 1828 AEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILN 1887
Query: 1547 AA---EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQ 1603
E +++ ++ L L +A A +L D Q++ AD EAWI ++
Sbjct: 1888 KVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADK 1947
Query: 1604 ELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR-NIKQLASRAQGLLSAGHPEGEQII 1662
E + ++ D + +L + +++ + + + ++ L+SA H + + I
Sbjct: 1948 ETSLKTNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIE 2007
Query: 1663 RLQGQVDKHYAGLKDVAEERKRK-------LENMYHLF-QLKRETDDLEQWISEKELVAS 1714
+ K + L + + ++K L+ LF + + L W + E S
Sbjct: 2008 ERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLS 2067
Query: 1715 SPEMGQDFDHVTLLRDKFRDF 1735
P + + L+ DF
Sbjct: 2068 EPVHCVSLNEIRQLQKDHEDF 2088
Score = 241 bits (614), Expect = 7e-63
Identities = 265/1344 (19%), Positives = 527/1344 (39%), Gaps = 106/1344 (7%)
Query: 810 PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEK 869
P+ + ++ R Q + YQ + R Q+L+++ L + D W+ EK
Sbjct: 15 PKVLETAEEIQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADDLGKWIMEKVN 74
Query: 870 WLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQ 929
L + D +++ + L+ E++T + + GH E K +
Sbjct: 75 ILTDKSYEDPT-NIQGKYQKHQSLEAEVQTKSRLMSELEKTREERFTMGHSAHEETKAHI 133
Query: 930 DHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAG 989
+ L W L E+ + + AL+ Y +C + +WI DK + S +LG D
Sbjct: 134 EELRHLWDLLLELTLEKGDQLLRALKFQQYVQECADILEWIGDKEAIATSV-ELGEDWER 192
Query: 990 IIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQS 1049
+ +K + ++ A + RV + + + + + + I +Q + W+ L+
Sbjct: 193 TEVLHKKFEDFQVELVAKEGRVVEVNQYANECAEENHPDLPLIQSKQNEVNAAWERLRGL 252
Query: 1050 LQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDE 1109
++ L + LQ F +D+ + W+ + + SED + L +E L H G++
Sbjct: 253 ALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPVLTSEDYGKDLVASEGLFHSHKGLERN 312
Query: 1110 IDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLG 1169
+ D + + EK+ + + + E L + W + + SR L
Sbjct: 313 LAVMSDKVKELCAKAEKLTLSHPS-DAPQIQEMKEDLVSSWEHIRALATSRYEKLQATYW 371
Query: 1170 FQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVD 1229
+ F D + ++ + + E P + E + + + +++ D+ S +
Sbjct: 372 YHRFSSDFDELSGWMNEKTAAINADELPTDVAGGEVLLDRHQQHKHEIDSYDDRFQSADE 431
Query: 1230 SGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
+G LV + SD+++EK++++++ E E L+ F ++ +++ W
Sbjct: 432 TGQDLVNANHEASDEVREKMEILDNNWTALLELWDERHRQYEQCLDFHLFYRDSEQVDSW 491
Query: 1290 IN--DKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFT 1347
++ + L ++D+ + + KH+ F + E + +D +L+ + +
Sbjct: 492 MSRQEAFLENEDLG-NSLGSAEALLQKHEDFEEAFTAQEEKIITVDKTATKLIGDDHYDS 550
Query: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDP 1407
+ + L D L+ + + L + + DL WI+ + +L D+
Sbjct: 551 ENIKAIRDGLLARRDALREKAATRRRLLKESLLLQKLYEDSDDLKNWINKKK-KLADDED 609
Query: 1408 GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLD----- 1462
KD+ ++ + K + E ++ V K +L + M E G A ++ R +
Sbjct: 610 YKDIQNLKSRVQKQQVFEKELAVNKTQLENIQKTGQEMIEGGHYASDNVTTRLSEVASLW 669
Query: 1463 --LLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKN 1520
LLE ++ QL + +LQ + ED W+E+ S DYG L VQ ++K+
Sbjct: 670 EELLEATKQKGTQLHEANQQLQFENNAEDLQRWLEDVEWQVTSEDYGKGLAEVQNRLRKH 729
Query: 1521 QTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL 1580
L++ + +V+ + E D +D+ R L ++ L+E A R ++L
Sbjct: 730 GLLESAVAARQDQVDILTDLAAYFEEIGHPDSKDIRARQESLVCRFEALKEPLATRKKKL 789
Query: 1581 RDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNI 1640
D Q D ++ EAWI E E S + KD + +L RH + + I
Sbjct: 790 LDLLHLQLICRDTEDEEAWIQETEPSATSTYLGKDLIASKKLLNRHRVILENIASHEPRI 849
Query: 1641 KQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD 1700
+++ R ++ GH E + ++++ L+ A R+ LE Q +
Sbjct: 850 QEITERGNKMVEEGHFAAEDVASRVKSLNQNMESLRARAARRQNDLEANVQFQQYLADLH 909
Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
+ E WI EKE + + G D + L K F + + G D++ A +
Sbjct: 910 EAETWIREKEPIVDNTNYGADEEAAGALLKKHEAFLLDLNSFG----DSMKALRNQANAC 965
Query: 1761 GHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHREL 1820
+AA + +G+ Q + A YD RE+
Sbjct: 966 QQQQAAPV----EGV------------AGEQRVMALYDFQA-------------RSPREV 996
Query: 1821 PEDVG----LDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQN 1876
G L +S + + +V A + + + V V++ + E+ I
Sbjct: 997 TMKKGDVLTLLSSINKDWWKVEAADHQGI-VPAVYVRRLAHDEFPMLPQRRREEPGNITQ 1055
Query: 1877 KEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVS 1936
+++++ +++LLD RR +L+ ++F A D+L W+ QE+ + +
Sbjct: 1056 RQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWI---------QEKKAENT 1106
Query: 1937 SVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREK---LQQVMSRRKE 1993
VEL + E++ + F L E L+ ++ ++++ + + R+E
Sbjct: 1107 GVELDDVW------ELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE 1160
Query: 1994 MNEKW---EARWERLRMLL----EVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEK 2046
+N +W + + R LL V F R+A + + + L++ D G + SV+
Sbjct: 1161 LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQA 1220
Query: 2047 LIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVSH 2106
L +RHE FE+ ++ L GETA SH
Sbjct: 1221 LQRRHEGFERDLVPLGDKVTIL---------------------------GETAERLSESH 1253
Query: 2107 HAATERTSPVSLWSRLSSSWESLQ 2130
ATE + L+ +WE LQ
Sbjct: 1254 PDATEDLQRQKM--ELNEAWEDLQ 1275
Score = 227 bits (578), Expect = 1e-58
Identities = 262/1268 (20%), Positives = 522/1268 (41%), Gaps = 83/1268 (6%)
Query: 434 RETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENY 493
RE + + L + D VEAA H+ I A Y R+ D L +
Sbjct: 994 REVTMKKGDVLTLLSSINKDWWKVEAAD--HQGIVP--AVYVRRLA--HDEFPMLPQRRR 1047
Query: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLS 553
+ IT R++ I + L + + RR+RL L + ++W+ E KA
Sbjct: 1048 EEPGNITQRQEQIENQYRSLLDRAEERRRRLLQRYNEFLLAYEAGDMLEWIQEKKAE--- 1104
Query: 554 AEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRIS 613
G L +V +L +K + D+ +++ I P Q+ Q+
Sbjct: 1105 -NTGVELDDVWELQKKFDEFQKDLNTNEPRLRDINKVADDLLFEGLLTPEGAQIRQE--- 1160
Query: 614 HLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVL 673
L + L +A ++ L + + F E D+ + I++K Q S+ D G DL SV
Sbjct: 1161 -LNSRWGSLQRLADEQRQLLGSAHAVEVFHREADDTKEQIEKKCQALSAADPGSDLFSVQ 1219
Query: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAA 733
LQR+H+ FE +L L + + + A + ++ + E++ W+ L+
Sbjct: 1220 ALQRRHEGFERDLVPLGDKVTILGETAERLSESHPDATEDLQRQKMELNEAWEDLQGRTK 1279
Query: 734 FCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
K++L +A+ F+ F A DL+ W+ ++S +++ +D L ++H++ ++E
Sbjct: 1280 DRKESLNEAQKFYLFLSKARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADME 1339
Query: 794 ESRGVMEHLEQ-QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYT 852
+ LE A+ SP++ +LQA++ + + R++ L + L+L
Sbjct: 1340 AEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQM 1399
Query: 853 VFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAAN 912
G D E WM +E L + +L+ LE + + D LD+ + +I + A
Sbjct: 1400 FQGNCDQVESWMVARENSL-RSDDKSSLDSLEALMKKRDDLDKAITAQEGKITDLEHFAE 1458
Query: 913 SLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITD 972
SL+ H E+ + RW+A + + + R + + + D EE +WI++
Sbjct: 1459 SLIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISE 1518
Query: 973 --KTKVVESTKDLGRDLAGIIAIQRKL---SGLERDVAAIQARVDALERESQQLMD--SH 1025
T ES KD IQRK +V +V + L++ +
Sbjct: 1519 MLPTACDESYKDATN-------IQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIECSAC 1571
Query: 1026 PEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVA 1085
+E + ++ + L+E W L + + L E S+ Q F + DF+ WLS + +A
Sbjct: 1572 DGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLA 1631
Query: 1086 SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEG 1145
+D L A LL++H ++ E+ +D+ + + E ++ T ++ ++ +
Sbjct: 1632 MKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIV-KKKDN 1690
Query: 1146 LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEA 1205
++ + + + + L + +F +D E+ + + ++ + L+ +
Sbjct: 1691 VNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQN 1750
Query: 1206 GIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQE 1265
++K + G + + + + +D KL + + ++I+ ++ + K E A+
Sbjct: 1751 LLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKA 1810
Query: 1266 ASVLLRDNLELQNFLQNCQELTLWINDK-LLTSQDVSYDEARNLHNKWLKHQAFVAELAS 1324
+ L ++LE F+QN +E WIN+K L + D + +KH+A + A
Sbjct: 1811 RGLKLEESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAV 1870
Query: 1325 HEGWLENIDAEGKQLMDEKPQFTAL---VSQKLEALHRLWDELQATTKEKTQHLSAARSS 1381
HE ++N+ A+G+ ++++ Q + +S K+EAL+ EKT L+ A ++
Sbjct: 1871 HETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALN-----------EKTPSLAKAIAA 1919
Query: 1382 DLRLQTHAD------------LNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQV- 1428
+LQ D + WI+ E L+++ G DL +LAK ++ +
Sbjct: 1920 -WKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLAKQDTLDASLQ 1978
Query: 1429 NVRKEELGELFAQVPSMGEEGGDADLSIE-------KRFLDLLEPLGRRKKQLESSRAKL 1481
+ ++E L E+ + + +IE KR+ LLE +++L + L
Sbjct: 1979 SFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPL 2038
Query: 1482 QISRDLEDE--------TLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
Q + DL E W E+ + +L ++ K ++ +
Sbjct: 2039 QKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQAD 2098
Query: 1534 VEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRL--------RDANE 1585
+ +L+ QQ+ + L+ +W L + R Q L ++
Sbjct: 2099 FKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEM 2158
Query: 1586 AQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLAS 1645
Q++ +A WI E Y + + K+ L+ + R+Q+ ++ R + ++
Sbjct: 2159 CQEFEQNASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKIVD 2218
Query: 1646 RAQGLLSA 1653
L A
Sbjct: 2219 LGDNLEDA 2226
Score = 208 bits (530), Expect = 4e-53
Identities = 197/977 (20%), Positives = 422/977 (43%), Gaps = 56/977 (5%)
Query: 1120 VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAK- 1178
V+ SG KV++ + + +R + + T + + R L Q F++DA
Sbjct: 10 VESSGPKVLETAEE-----IQERRQEVLTRYQSFKERVAERGQKLEDSYHLQVFKRDADD 64
Query: 1179 ------QAEAILSNQEYTLAHLEPPDSLE-------AAEAGIRKFEDFLGSMENNRDKVL 1225
+ IL+++ Y E P +++ + EA ++ + +E R++
Sbjct: 65 LGKWIMEKVNILTDKSY-----EDPTNIQGKYQKHQSLEAEVQTKSRLMSELEKTREERF 119
Query: 1226 SPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQE 1285
+ G+ E + ++++ L+ + + ++ A L+ Q ++Q C +
Sbjct: 120 T---MGHSAHEETKAHIEELRHLWDLLLELTLEKGDQLLRA-------LKFQQYVQECAD 169
Query: 1286 LTLWINDK--LLTSQDVSYDEARN--LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD 1341
+ WI DK + TS ++ D R LH K+ + F EL + EG + ++ + +
Sbjct: 170 ILEWIGDKEAIATSVELGEDWERTEVLHKKF---EDFQVELVAKEGRVVEVNQYANECAE 226
Query: 1342 EKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQ 1401
E L+ K ++ W+ L+ ++ + LS A + + + +WI E
Sbjct: 227 ENHPDLPLIQSKQNEVNAAWERLRGLALQRQKALSNAANLQRFKRDVTEAIQWIKEKEPV 286
Query: 1402 LRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFL 1461
L S+D GKDL + + K +E + V +++ EL A+ + I++
Sbjct: 287 LTSEDYGKDLVASEGLFHSHKGLERNLAVMSDKVKELCAKAEKLTLSHPSDAPQIQEMKE 346
Query: 1462 DLLEPLGRRKKQLESSRAKLQ-------ISRDLEDETLWVEERLPLAQSADYGTNLQTVQ 1514
DL+ + S KLQ S D ++ + W+ E+ + + T++ +
Sbjct: 347 DLVSSWEHIRALATSRYEKLQATYWYHRFSSDFDELSGWMNEKTAAINADELPTDVAGGE 406
Query: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
+ + ++Q ++EI + R + + GQ LV A ++ E++ L ++W L E
Sbjct: 407 VLLDRHQQHKHEIDSYDDRFQSADETGQDLVNANHEASDEVREKMEILDNNWTALLELWD 466
Query: 1575 GRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVE 1634
R ++ + +Y D+++ ++W+ QE ++ ++++ A +L++H + A
Sbjct: 467 ERHRQYEQCLDFHLFYRDSEQVDSWMSRQEAFLENEDLGNSLGSAEALLQKHEDFEEAFT 526
Query: 1635 DYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQ 1694
I + A L+ H + E I ++ + L++ A R+R L+ L +
Sbjct: 527 AQEEKIITVDKTATKLIGDDHYDSENIKAIRDGLLARRDALREKAATRRRLLKESLLLQK 586
Query: 1695 LKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFI 1754
L ++DDL+ WI++K+ +A + +D ++ K + F +E A+ + +++N+
Sbjct: 587 LYEDSDDLKNWINKKKKLADDEDY-KDIQNLKSRVQKQQVFEKEL-AVNKTQLENIQKTG 644
Query: 1755 ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTR-MQLLAASYDLHRYFYTGAEILG-- 1811
+ +I+ GH + + + +W +LLE + QL A+ L F AE L
Sbjct: 645 QEMIEGGHYASDNVTTRLSEVASLWEELLEATKQKGTQLHEANQQLQ--FENNAEDLQRW 702
Query: 1812 LIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKA 1871
L D + + ED G + ++ R H E + QV D+A + +
Sbjct: 703 LEDVEWQVTSEDYGKGLAEVQNRLRKHGLLESAVAARQDQVDILTDLAAYFEEIGHPDSK 762
Query: 1872 EAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQER 1931
+ I+ +++ + ++AL + A R+ +L+D D +W++ +
Sbjct: 763 D-IRARQESLVCRFEALKEPLATRKKKLLDLLHLQLICRDTEDEEAWIQETEPSATSTYL 821
Query: 1932 PRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRR 1991
+D+ + + L+ H+ I I + E G +++ H A+E++ +++ +
Sbjct: 822 GKDLIASKKLLNRHRVILENIASHEPRIQEITERGNKMVEEGHFAAEDVASRVKSLNQNM 881
Query: 1992 KEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRH 2051
+ + + R L ++ Q+ D AE W+ +EP + + ++G ++ L+K+H
Sbjct: 882 ESLRARAARRQNDLEANVQFQQYLADLHEAETWIREKEPIVDNTNYGADEEAAGALLKKH 941
Query: 2052 EAFEKSTASWAERFAAL 2068
EAF S+ + AL
Sbjct: 942 EAFLLDLNSFGDSMKAL 958
Score = 171 bits (433), Expect = 7e-42
Identities = 202/962 (20%), Positives = 402/962 (41%), Gaps = 74/962 (7%)
Query: 311 ASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT--VEKPPKFQEKGNLEVLLFT 368
A DL WI +++S++ A LTG++ L+ +R + P FQ + L
Sbjct: 1298 ARDLQNWISSIGGMVSSQELAEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAEL-- 1355
Query: 369 IQSRMRANNQKVYTPHDGKLV-SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRF 427
I S A+ + KL D+ +AWE + + I + LE + F
Sbjct: 1356 IDSGHHASPEIEKKLQAVKLERDDLEKAWE-------------KRKKILDQCLE--LQMF 1400
Query: 428 DRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE 487
E+W+ + + D+ L ++EA KK + ++ A E ++ LE A+
Sbjct: 1401 QGNCDQVESWMVARENSLRSDDKS-SLDSLEALMKKRDDLDKAITAQEGKITDLEHFAES 1459
Query: 488 LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEI 547
L + ++ ++ I R +L W L+ L R +L L++ ++D+ +W+ E+
Sbjct: 1460 LIADEHYAKEEIATRLQRVLDRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEM 1519
Query: 548 KAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCD--P 605
+ K ++ KH+ ++ + ++V + E CD
Sbjct: 1520 LPTACDESY-KDATNIQRKYLKHQTFAHEVDGRSEQVHGVINLGNSLIE---CSACDGNE 1575
Query: 606 QVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDY 665
+ +++++ L++ ++ L + +L ++ R +F + + E W+ E E + + D
Sbjct: 1576 EAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQ 1635
Query: 666 GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQW 725
+DL S L +KH+ E E+ + L+ + A +++ F QI + V+ ++
Sbjct: 1636 ARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAEDLLSSGTFNVDQIVKKKDNVNKRF 1695
Query: 726 DQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKH 785
+++LAA + L++A FQF D DD ++W+++ +S +D G+D + L KKH
Sbjct: 1696 LNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKH 1755
Query: 786 KDFLEELEESRGVMEHLEQQAQGFPEEFR-DSPDVTHRLQALRELYQQVVAQADLRQQRL 844
K EL ++++ A+ ++ ++ RL E ++++ A R +L
Sbjct: 1756 KRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKL 1815
Query: 845 QEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQI 904
+E+L+ + E W+ EK + DTL + + + + L+ + T++
Sbjct: 1816 EESLEYLQFMQNAEEEEAWINEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRV 1875
Query: 905 DGVNLAANSL---VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAV--DSALRVHNY 959
V + V +++E+ + LN + + ++ + + D A + N+
Sbjct: 1876 QNVCAQGEDILNKVLQEESQNKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNW 1935
Query: 960 CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAI-QARVDALERES 1018
D E WI DK ++ T G DL + + K L+ + + Q R+ +
Sbjct: 1936 KADVVEA--WIADKETSLK-TNGNGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLK 1992
Query: 1019 QQLMDSHPEQKEDIGQRQKHLEELWQGL--------------QQSLQGQEDLLGEVSQLQ 1064
+L+ + Q + I +R L + W+ L Q LQ EDL E +
Sbjct: 1993 DKLISAQHNQSKAIEERYAALLKRWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKA 2052
Query: 1065 AFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESG 1124
+ L + W ++ ++ SL E QL + H + Q ++ + E
Sbjct: 2053 SALNN------WCEKMEENLSEPVHCVSLNEIRQLQKDHEDFLASLARAQADFKCLLELD 2106
Query: 1125 EKV-IQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL-----AQCLGF---QEFQK 1175
+++ G Y L +E L+ W L + E R L Q F QEF++
Sbjct: 2107 QQIKALGVPSSPYTWL--TVEVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQ 2164
Query: 1176 DAKQ-AEAILSNQEYTL--AHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGN 1232
+A + IL + Y L + L+ +LE+ ++ + + +M+ K+ VD G+
Sbjct: 2165 NASTFLQWILETRAYFLDGSLLKETGTLESQLEANKRKQKEIQAMKRQLTKI---VDLGD 2221
Query: 1233 KL 1234
L
Sbjct: 2222 NL 2223
Score = 164 bits (414), Expect = 1e-39
Identities = 204/1037 (19%), Positives = 417/1037 (40%), Gaps = 84/1037 (8%)
Query: 299 ETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQE 358
E EK ++ DL E+ +L+ G Q++++ R E + +
Sbjct: 1365 EIEKKLQAVKLERDDLEKAWEKRKKILDQCLELQMFQGNCDQVESWMVAR--ENSLRSDD 1422
Query: 359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEY--RRELALRNELI- 415
K +L+ L ++ R + K T +GK ++D+ ESL E+ + E+A R + +
Sbjct: 1423 KSSLDSLEALMKKR--DDLDKAITAQEGK-ITDLEHFAESLIADEHYAKEEIATRLQRVL 1479
Query: 416 ------------RQEKLEQLA--RRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461
+ KL A ++F R E W+SE +++ D ++
Sbjct: 1480 DRWKALKAQLIDERTKLGDYANLKQFYRDLEELEEWISEMLPTACDESYK-DATNIQRKY 1538
Query: 462 KKHEAIETDTAAYEERVRALEDLAQELEKENYHD--QKRITARKDNILRLWSYLQELLQS 519
KH+ + E+V + +L L + + D ++ + + + + W +L E
Sbjct: 1539 LKHQTFAHEVDGRSEQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTND 1598
Query: 520 RRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAI 579
+ ++L Q+ + W+ E + L + + L +LL+KH+L+E ++
Sbjct: 1599 KGKKLNEASRQQRFNTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLA 1658
Query: 580 QGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRL 639
+ D +K + + Q+++ + ++ + F + +AA +L+++ L
Sbjct: 1659 REDALKDLNTLAEDLLSSGTFNV--DQIVKKK-DNVNKRFLNVQELAAAHHEKLKEAYAL 1715
Query: 640 WKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQE 699
++FF ++D+ ESWI+EK SS DYG+DL V L +KHK E EL + ++ +
Sbjct: 1716 FQFFQDLDDEESWIEEKLIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDM 1775
Query: 700 AHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWL 759
A + + G +I+ R+ + W++LK+LA L+++ + QF +A++ +AW+
Sbjct: 1776 AEKLKDKAAVGQEEIQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWI 1835
Query: 760 QDAHRLLSGEDVGQDEGATRALGKKHK----DFLEELEESRGVMEHLEQQAQGFPEEFRD 815
+ + L D G AT++L KH+ DF + V E +E
Sbjct: 1836 NEKNALAVRGDCGDTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQ 1895
Query: 816 SPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEKEKWLAEME 875
+ +++ +++AL E + + +L++ + D E W+ +KE L
Sbjct: 1896 NKEISSKIEALNEKTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNG 1955
Query: 876 MPDTLEDLEVVQHRFDILDQEMKTLMTQ-IDGVNLAANSLVESGHPRSREVKQYQDHLNT 934
L D + + D LD +++ + + + + L+ + H +S+ +++ L
Sbjct: 1956 NGADLGDFLTLLAKQDTLDASLQSFQQERLPEITDLKDKLISAQHNQSKAIEERYAALLK 2015
Query: 935 RWQAFQTLVSERR------------------EAVDSALRVHNYCVDCEETSKWITDKTKV 976
RW+ + R E A ++N+C EE +++
Sbjct: 2016 RWEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEEN---LSEPVHC 2072
Query: 977 VESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQL----MDSHPE---QK 1029
V L I +Q+ +A QA L QQ+ + S P
Sbjct: 2073 V--------SLNEIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTV 2124
Query: 1030 EDIGQRQKHLEELWQGLQQSLQGQE-DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASED 1088
E + + KHL ++ + +Q LQ +E + Q F Q+ F W+ T+
Sbjct: 2125 EVLERTWKHLSDIIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWILETRAYFLDGS 2184
Query: 1089 MPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDT 1148
+ + E L+ + + EI + ++ + G+ + D L + GL
Sbjct: 2185 LLKETGTLESQLEANKRKQKEIQAMKRQLTKIVDLGDNL----EDALILDIKYSTIGLAQ 2240
Query: 1149 GWNALGRMWESRSHTLAQCLGFQEF----QKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
W+ L ++ H L Q + ++ ++ K+ I + + L +
Sbjct: 2241 QWDQLYQLGLRMQHNLEQQIQAKDIKGVSEETLKEFSTIYKHFDENLTGRLTHKEFRSCL 2300
Query: 1205 AGIRKFEDFLGSMENNR--DKVLSPVDSGNKLVAEGNLYS----DKIKEKVQLIEDRHRK 1258
G+ + + E+ +K L VD G K Y+ DK E ++ ++
Sbjct: 2301 RGLNYYLPMVEEDEHEPKFEKFLDAVDPGRKGYVSLEDYTAFLIDKESENIKSSDEIENA 2360
Query: 1259 NNEKAQEASVLLRDNLE 1275
A+ S + +++++
Sbjct: 2361 FQALAEGKSYITKEDMK 2377
Score = 149 bits (377), Expect = 2e-35
Identities = 191/937 (20%), Positives = 367/937 (39%), Gaps = 66/937 (7%)
Query: 391 DINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF 450
++N AWE L+ R+ +L Q F KA + W+S +V+
Sbjct: 1266 ELNEAWEDLQGRTKDRKESLNEA--------QKFYLFLSKARDLQNWISSIGGMVSSQEL 1317
Query: 451 GYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLW 510
DL +E ++H+ D A +ALED + EL +H I + +
Sbjct: 1318 AEDLTGIEILLERHQEHRADMEAEAPTFQALEDFSAELIDSGHHASPEIEKKLQAVKLER 1377
Query: 511 SYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570
L++ + R++ L+ L LQ +FQ ++ + + L ++ L +E L++K
Sbjct: 1378 DDLEKAWEKRKKILDQCLELQ-MFQGNCDQVESWMVARENSLRSDDKSSLDSLEALMKKR 1436
Query: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
++ I Q K+ + + Y + I R+ + ++ L +
Sbjct: 1437 DDLDKAITAQEGKITDLEHFAESLIADEHYA---KEEIATRLQRVLDRWKALKAQLIDER 1493
Query: 631 AQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLD 690
+L L +F+ +++E E WI E Y KD T++ KH+ F E+ G
Sbjct: 1494 TKLGDYANLKQFYRDLEELEEWISEMLPTACDESY-KDATNIQRKYLKHQTFAHEVDGRS 1552
Query: 691 AHLEQIFQEAHGMV--ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+ + + ++ + ++ +++++ WD L + K L +A +F
Sbjct: 1553 EQVHGVINLGNSLIECSACDGNEEAMKEQLEQLKEHWDHLLERTNDKGKKLNEASRQQRF 1612
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQG 808
D + WL +A LL+ +D +D + L KKH+ E+ ++ L A+
Sbjct: 1613 NTSIRDFEFWLSEAETLLAMKDQARDLASAGNLLKKHQLLEREMLAREDALKDLNTLAED 1672
Query: 809 FPEEFRDSPD-VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGEK 867
+ D + + + + + V A ++L+EA L+ F + D E W+ EK
Sbjct: 1673 LLSSGTFNVDQIVKKKDNVNKRFLNVQELAAAHHEKLKEAYALFQFFQDLDDEESWIEEK 1732
Query: 868 EKWLAEMEMPDTLEDLEVVQH---RFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
L + D DL+ VQ+ + L+ E+ I V A L + E
Sbjct: 1733 ---LIRVSSQDYGRDLQGVQNLLKKHKRLEGELVAHEPAIQNVLDMAEKLKDKAAVGQEE 1789
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
++ W+ + L R ++ +L + + EE WI +K + D G
Sbjct: 1790 IQLRLAQFVEHWEKLKELAKARGLKLEESLEYLQFMQNAEEEEAWINEK-NALAVRGDCG 1848
Query: 985 RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD---SHPEQKEDIGQRQKHLEE 1041
LA ++ K LE D A + RV + + + +++ Q ++I + + L E
Sbjct: 1849 DTLAATQSLLMKHEALENDFAVHETRVQNVCAQGEDILNKVLQEESQNKEISSKIEALNE 1908
Query: 1042 LWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQ 1101
L +++ + L + Q F D +AW++ + ++ + L + LL
Sbjct: 1909 KTPSLAKAIAAWKLQLEDDYAFQEFNWKADVVEAWIADKETSLKTNGNGADLGDFLTLLA 1968
Query: 1102 QHAGIKDEIDGHQDSYQR-----VKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
+ +D +D S+Q+ + + +K+I Q + + + ++ + AL +
Sbjct: 1969 K----QDTLDASLQSFQQERLPEITDLKDKLISAQHN--------QSKAIEERYAALLKR 2016
Query: 1157 WES--------RSHTLAQCLGFQE----FQKDAKQAEAILSNQEYTLAHLEPP---DSLE 1201
WE R L + L Q+ F + A +A A+ + E +L P SL
Sbjct: 2017 WEQLLEASAVHRQKLLEKQLPLQKAEDLFVEFAHKASALNNWCEKMEENLSEPVHCVSLN 2076
Query: 1202 AAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIE-------D 1254
+ EDFL S+ + ++ ++ A G S V+++E D
Sbjct: 2077 EIRQLQKDHEDFLASLARAQADFKCLLELDQQIKALGVPSSPYTWLTVEVLERTWKHLSD 2136
Query: 1255 RHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLWI 1290
+ ++ Q+ N E+ Q F QN WI
Sbjct: 2137 IIEEREQELQKEEARQVKNFEMCQEFEQNASTFLQWI 2173
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 439 bits (1129), Expect = e-122
Identities = 265/716 (37%), Positives = 397/716 (55%), Gaps = 36/716 (5%)
Query: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE LPKP +GKMR+H
Sbjct: 49 EKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHK 108
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 109 INNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISV------EE 162
Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
SAK+ LLLWCQ KTA Y +VNV NF SWKDGLAFNALIH+HRP+LI++DKL+ +
Sbjct: 163 TSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVT 222
Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
NL +AF VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 223 NLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 282
Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
KV+ E E ++E Y LASDLL WI +TI L R ++ +QQ+L+ F YR V
Sbjct: 283 KVLAVNQENEHLMEDYEKLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVH 342
Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
KPPK QEK LE+ T+Q+++R +N+ + P +GK+VSDIN W+ LE+AE E L
Sbjct: 343 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLL 402
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVA-QDNFGYDLAAVEAAKKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ +D L+ ++A +KHEA E+D
Sbjct: 403 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESD 462
Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
AA+++RV + +AQEL + +Y+D + R I W L L SRR+ LE T
Sbjct: 463 LAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKT-EK 521
Query: 531 QKLFQDMLH---------SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH----------- 570
Q D LH +WM+ L + E+E L+ H
Sbjct: 522 QLEAIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDAD 581
Query: 571 KLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRK 630
+ EA +AI + + + +K + Y PQ+I + ++Q + + +
Sbjct: 582 REREAILAIHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQ 641
Query: 631 AQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRG 688
++ + ++ L + F + + WI+ K + + ++ L Q H K +E +
Sbjct: 642 SKQQSNEHLRRQFASQANVVGPWIQTKMEEIGRISI--EMNGTLEDQLSHLKQYERSIVD 699
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
+L+ + Q+ + F + ++ + W+QL A + + + EN
Sbjct: 700 YKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 752
Score = 48.1 bits (113), Expect = 9e-05
Identities = 71/334 (21%), Positives = 137/334 (41%), Gaps = 45/334 (13%)
Query: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
+F+ A +AW +L D E AT +AL +KH+ F +L + +E +
Sbjct: 417 KFRQKASIHEAWTDGKEAMLKHRDY---ETATLSDIKALIRKHEAFESDLAAHQDRVEQI 473
Query: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
AQ E ++ DS +V R Q + + + + + R++ L+ EA+D L+ +
Sbjct: 474 AAIAQELNELDYYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEY 533
Query: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDIL-------DQEMKTLMTQIDG 906
+ A WM + L +M + T+E++E + D D+E + ++
Sbjct: 534 AKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILA---- 589
Query: 907 VNLAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV---------DSA 953
++ A + ES H + Y +N++W+ Q LV +R A+ +
Sbjct: 590 IHKEAQRIAESNHIKLSGSNPYTTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEH 649
Query: 954 LRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVD 1012
LR + WI K +E + ++ G + Q L ER + + +D
Sbjct: 650 LR-RQFASQANVVGPWIQTK---MEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLD 705
Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
LE++ Q + ++ + +H+ W+ L
Sbjct: 706 LLEQQHQLIQEALIFDNKHTNYTMEHIRVGWEQL 739
Score = 44.3 bits (103), Expect = 0.001
Identities = 66/270 (24%), Positives = 106/270 (39%), Gaps = 38/270 (14%)
Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
A++G +KAE N+ +V A Q L++ +K +A DLL W+ I
Sbjct: 267 AFSGAQKAETAANRICKVLAVNQ--------ENEHLMEDYEK-----LASDLLEWIRRTI 313
Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
+E + E RD V K + EI + L + +
Sbjct: 314 PWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 373
Query: 1971 QRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAEAWLI 2026
+ + +I Q + K E+W R ERL L E +F + AS+ EAW
Sbjct: 374 PSEGKMVSDINNGWQHLEQAEKGY-EEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTD 430
Query: 2027 AQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERP 2085
+E L D+ T+ ++ LI++HEAFE A+ +R + EL E +
Sbjct: 431 GKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSH 489
Query: 2086 AEETGPQE--EEGETAGEAPVSHHAATERT 2113
T Q+ ++ + G S A E+T
Sbjct: 490 NVNTRCQKICDQWDALGSLTHSRREALEKT 519
Score = 42.7 bits (99), Expect = 0.004
Identities = 84/422 (19%), Positives = 159/422 (37%), Gaps = 48/422 (11%)
Query: 1236 AEGNLYSDKIKEKVQLIEDRHRKNNE-KAQEASVLLRDNLELQNFLQNCQELTLWINDKL 1294
+EG + SD I Q +E + E E L R + + F Q W + K
Sbjct: 375 SEGKMVSD-INNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKE 433
Query: 1295 LTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQ 1352
+ Y+ A K L KH+AF ++LA+H+ +E I A ++L + + V+
Sbjct: 434 AMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNT 493
Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSS-----DLRLQ---THADLNKWI-SAMED--- 1400
+ + + WD L + T + + L L L+ A N W+ SAMED
Sbjct: 494 RCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDLQD 553
Query: 1401 ------------------QLRSD--DPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
Q +S D ++ ++ + + +R+ + +++
Sbjct: 554 MFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTT 613
Query: 1441 QVPSM-GEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLP 1499
P + + + KR LLE + KQ + + Q + W++ ++
Sbjct: 614 VTPQIINSKWEKVQQLVPKRDHALLE---EQSKQQSNEHLRRQFASQANVVGPWIQTKME 670
Query: 1500 LAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERL 1559
N T++ + + + I+ + P ++ + Q+ Q + EA D + +
Sbjct: 671 EIGRISIEMN-GTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTM 729
Query: 1560 GHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDAD-EAEAWIGEQELYVISDEIPKDEEG 1618
H++ W++L A R NE + L D + + QE + KD G
Sbjct: 730 EHIRVGWEQLLTTIA------RTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGG 783
Query: 1619 AI 1620
A+
Sbjct: 784 AL 785
Score = 42.0 bits (97), Expect = 0.006
Identities = 55/305 (18%), Positives = 124/305 (40%), Gaps = 38/305 (12%)
Query: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
W K +++ L+ I A+ RK E D+AA Q RV+ + +Q+L +
Sbjct: 428 WTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 487
Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
++ R + + + W L +++L+ E L + QL + + F W+
Sbjct: 488 SHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESA 547
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIKDEIDG-----------HQDSYQRVKESGEKVIQ 1129
+ + + ++ E E L+ H K + H+++ QR+ ES +
Sbjct: 548 MEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEA-QRIAESNHIKLS 606
Query: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN--- 1186
G Y + ++ +++ W + ++ R H L + Q+ + ++ A +N
Sbjct: 607 GSN--PYTTVTPQI--INSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVG 662
Query: 1187 -------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGN 1239
+E +E +LE + ++++E + + N D ++ ++L+ E
Sbjct: 663 PWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDL----LEQQHQLIQEAL 718
Query: 1240 LYSDK 1244
++ +K
Sbjct: 719 IFDNK 723
Score = 40.0 bits (92), Expect = 0.024
Identities = 41/206 (19%), Positives = 88/206 (42%), Gaps = 26/206 (12%)
Query: 1880 EVSAAWQALLDACAG---------RRTQLVD-TADKFRFFSMARDLLSWMESIIRQIETQ 1929
+++ WQ L A G RR + +D A+KFR + + +W + ++ +
Sbjct: 382 DINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHE--AWTDGKEAMLKHR 439
Query: 1930 E-RPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988
+ +S ++ L++ H+ +++ + + L + + S + + Q++
Sbjct: 440 DYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKIC 499
Query: 1989 SR----------RKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFG 2038
+ R+E EK E + E + L ++++ A+ W+ + L
Sbjct: 500 DQWDALGSLTHSRREALEKTEKQLEAIDQLH--LEYAKRAAPFNNWMESAMEDLQDMFIV 557
Query: 2039 HTVDSVEKLIKRHEAFEKSTASWAER 2064
HT++ +E LI H+ F KST A+R
Sbjct: 558 HTIEEIEGLISAHDQF-KSTLPDADR 582
Score = 37.4 bits (85), Expect = 0.16
Identities = 43/240 (17%), Positives = 90/240 (37%), Gaps = 40/240 (16%)
Query: 800 EHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDA 859
+HLEQ +G+ E + RL L E ++Q +
Sbjct: 388 QHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQ-----------------------KASI 424
Query: 860 CELWMGEKEKWLAEMEMPD-TLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESG 918
E W KE L + TL D++ + + + + ++ +++ + A L E
Sbjct: 425 HEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELD 484
Query: 919 HPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALR-------VH-NYCVDCEETSKWI 970
+ S V + +W A +L RREA++ + +H Y + W+
Sbjct: 485 YYDSHNVNTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWM 544
Query: 971 TDKTKVVESTKDLG-----RDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSH 1025
+E +D+ ++ G+I+ + D + + A+ +E+Q++ +S+
Sbjct: 545 ---ESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESN 601
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 431 bits (1107), Expect = e-120
Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)
Query: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE L KP +GKMR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
SAK+ LLLWCQ KTA Y +VN+ NF SWKDGL F ALIH+HRP+LID+ KL+ +
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
NL AF+VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
KV+ E E+++E Y LASDLL WI +TI L +R N++ +QQ+L+ F YR +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
KPPK QEK LE+ T+Q+++R +N+ + P +G++VSDIN AW LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L+ ++A KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
AA+++RV + +AQEL + +Y+D + AR I W L L Q RR+ LE T L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
+ + +WM+ L + E++ L H+ L +AD
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
Query: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
+ I + K + + Y PQ I + H+ Q A
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
Query: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
+ + ++RL K F + + WI+ K + + ++ L Q H + +E +
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
++Q+ + + F + ++ + W+QL A + + + EN
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
Score = 55.8 bits (133), Expect = 4e-07
Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)
Query: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
+KL D+L +I W++ + L + D + HK + Q +
Sbjct: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
Query: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
L+ + + P + +++ D I++ C E++ +LE+ L K
Sbjct: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
Query: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
F + E+W KE + DY L+ + L +KH+AFE +L +EQI A
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
Query: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
+ + P + AR +++ QWD L L ++ L+ E + ++ A
Sbjct: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
Query: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
W++ A L + + L H+ F L + ++ R G+ + +
Sbjct: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
Query: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Q + P+E D +L R+ Q + + RQQ + L
Sbjct: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
Query: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
FG + + W+ K + + +EM TLED +++ K + Q++G +
Sbjct: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
Query: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
L +L+ ++ +H+ W+ T ++ V++ +
Sbjct: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
Score = 50.8 bits (120), Expect = 1e-05
Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
+F+ A +AW +L +D E AT +AL KKH+ F +L + +E +
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
Query: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
AQ E ++ DSP V R Q + + + + A R++ L+ E +D LY +
Sbjct: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
Query: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
+ A WM + L + + T+E+++ + Q + + D + + L I G++
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
Query: 909 LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
+ +V++ H Y +N +W + LV R +A+ + A + HN
Sbjct: 573 NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
Query: 959 --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
+ WI K +E + ++ G + Q L E+ + + ++D LE
Sbjct: 633 KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
Query: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
+ Q + ++ + +H+ W+ L
Sbjct: 690 GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
Score = 48.5 bits (114), Expect = 7e-05
Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
++ E +QLM++ + L S LE + R L+ E T H + D R
Sbjct: 268 VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
+Q L + ++ +LR + + S RM++ + + Q
Sbjct: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
V E+G + L E R L+ L+ L + +Q S W + + +
Sbjct: 374 V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
Query: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
+ DY T L ++ +KK++ ++++ H RVE + Q+L E D + R
Sbjct: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
+ WD L Q+ R+A E + L+
Sbjct: 478 KICDQWDNL----GALTQKRREALERTEKLLE 505
Score = 48.1 bits (113), Expect = 9e-05
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)
Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
A++G +KAE N+ +V A Q QL++ +K +A DLL W+ I
Sbjct: 248 AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
+E + E RD + K + EI + L + +
Sbjct: 295 PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
Query: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
+ + +I L+QV +E R ERL L E +F + AS+ EAW
Sbjct: 355 PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
Query: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
+E L D+ T+ ++ L+K+HEAFE A+ +R + EL E + P+
Sbjct: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
Query: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
Q+ ++ + G A ERT
Sbjct: 472 VNARCQKICDQWDNLGALTQKRREALERT 500
Score = 38.5 bits (88), Expect = 0.071
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)
Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
+ F Q W + K + Y+ A K L KH+AF ++LA+H+ +E I A
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
++L + + V+ + + + WD L A T+++ + L L L+
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 1387 THADLNKWI-SAMED 1400
A N W+ AMED
Sbjct: 517 RAAPFNNWMEGAMED 531
Score = 37.4 bits (85), Expect = 0.16
Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)
Query: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
W K ++ L+ I A+ +K E D+AA Q RV+ + +Q+L +
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
+ R + + + W L +++L+ E LL + QL +
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
Query: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
++DL D I A E +LP+A++ GI +E+ +Y
Sbjct: 529 MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
V T+P + Q + G W+ + ++ R L + Q+ + ++
Sbjct: 584 ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
Query: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
+N +E +E +LE + +R++E S+ N + K+ ++ ++
Sbjct: 638 QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
Query: 1234 LVAEGNLYSDK 1244
L+ E ++ +K
Sbjct: 694 LIQEALIFDNK 704
Score = 36.2 bits (82), Expect = 0.35
Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)
Query: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
RR + +D A+KFR + + +W E+++RQ + + +S ++ L+K H+ +
Sbjct: 387 RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
++ + + L + + S + + Q++ + + +K ER
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
LLE ++++ A+ W+ L HT++ ++ L HE F+
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 431 bits (1107), Expect = e-120
Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)
Query: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE L KP +GKMR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
SAK+ LLLWCQ KTA Y +VN+ NF SWKDGL F ALIH+HRP+LID+ KL+ +
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
NL AF+VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
KV+ E E+++E Y LASDLL WI +TI L +R N++ +QQ+L+ F YR +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
KPPK QEK LE+ T+Q+++R +N+ + P +G++VSDIN AW LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L+ ++A KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
AA+++RV + +AQEL + +Y+D + AR I W L L Q RR+ LE T L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
+ + +WM+ L + E++ L H+ L +AD
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
Query: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
+ I + K + + Y PQ I + H+ Q A
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
Query: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
+ + ++RL K F + + WI+ K + + ++ L Q H + +E +
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
++Q+ + + F + ++ + W+QL A + + + EN
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
Score = 55.8 bits (133), Expect = 4e-07
Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)
Query: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
+KL D+L +I W++ + L + D + HK + Q +
Sbjct: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
Query: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
L+ + + P + +++ D I++ C E++ +LE+ L K
Sbjct: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
Query: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
F + E+W KE + DY L+ + L +KH+AFE +L +EQI A
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
Query: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
+ + P + AR +++ QWD L L ++ L+ E + ++ A
Sbjct: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
Query: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
W++ A L + + L H+ F L + ++ R G+ + +
Sbjct: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
Query: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Q + P+E D +L R+ Q + + RQQ + L
Sbjct: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
Query: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
FG + + W+ K + + +EM TLED +++ K + Q++G +
Sbjct: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
Query: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
L +L+ ++ +H+ W+ T ++ V++ +
Sbjct: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
Score = 50.8 bits (120), Expect = 1e-05
Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
+F+ A +AW +L +D E AT +AL KKH+ F +L + +E +
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
Query: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
AQ E ++ DSP V R Q + + + + A R++ L+ E +D LY +
Sbjct: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
Query: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
+ A WM + L + + T+E+++ + Q + + D + + L I G++
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
Query: 909 LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
+ +V++ H Y +N +W + LV R +A+ + A + HN
Sbjct: 573 NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
Query: 959 --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
+ WI K +E + ++ G + Q L E+ + + ++D LE
Sbjct: 633 KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
Query: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
+ Q + ++ + +H+ W+ L
Sbjct: 690 GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
Score = 48.5 bits (114), Expect = 7e-05
Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
++ E +QLM++ + L S LE + R L+ E T H + D R
Sbjct: 268 VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
+Q L + ++ +LR + + S RM++ + + Q
Sbjct: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
V E+G + L E R L+ L+ L + +Q S W + + +
Sbjct: 374 V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
Query: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
+ DY T L ++ +KK++ ++++ H RVE + Q+L E D + R
Sbjct: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
+ WD L Q+ R+A E + L+
Sbjct: 478 KICDQWDNL----GALTQKRREALERTEKLLE 505
Score = 48.1 bits (113), Expect = 9e-05
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)
Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
A++G +KAE N+ +V A Q QL++ +K +A DLL W+ I
Sbjct: 248 AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
+E + E RD + K + EI + L + +
Sbjct: 295 PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
Query: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
+ + +I L+QV +E R ERL L E +F + AS+ EAW
Sbjct: 355 PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
Query: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
+E L D+ T+ ++ L+K+HEAFE A+ +R + EL E + P+
Sbjct: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
Query: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
Q+ ++ + G A ERT
Sbjct: 472 VNARCQKICDQWDNLGALTQKRREALERT 500
Score = 38.5 bits (88), Expect = 0.071
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)
Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
+ F Q W + K + Y+ A K L KH+AF ++LA+H+ +E I A
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
++L + + V+ + + + WD L A T+++ + L L L+
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 1387 THADLNKWI-SAMED 1400
A N W+ AMED
Sbjct: 517 RAAPFNNWMEGAMED 531
Score = 37.4 bits (85), Expect = 0.16
Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)
Query: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
W K ++ L+ I A+ +K E D+AA Q RV+ + +Q+L +
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
+ R + + + W L +++L+ E LL + QL +
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
Query: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
++DL D I A E +LP+A++ GI +E+ +Y
Sbjct: 529 MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
V T+P + Q + G W+ + ++ R L + Q+ + ++
Sbjct: 584 ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
Query: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
+N +E +E +LE + +R++E S+ N + K+ ++ ++
Sbjct: 638 QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
Query: 1234 LVAEGNLYSDK 1244
L+ E ++ +K
Sbjct: 694 LIQEALIFDNK 704
Score = 36.2 bits (82), Expect = 0.35
Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)
Query: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
RR + +D A+KFR + + +W E+++RQ + + +S ++ L+K H+ +
Sbjct: 387 RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
++ + + L + + S + + Q++ + + +K ER
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
LLE ++++ A+ W+ L HT++ ++ L HE F+
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 431 bits (1107), Expect = e-120
Identities = 260/715 (36%), Positives = 390/715 (54%), Gaps = 34/715 (4%)
Query: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
E Q+KTFT W NSHL + +I ++ +D RDG L+ LLEV+SGE L KP +GKMR+H
Sbjct: 30 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHK 89
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 90 ISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISV------EE 143
Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
SAK+ LLLWCQ KTA Y +VN+ NF SWKDGL F ALIH+HRP+LID+ KL+ +
Sbjct: 144 TSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLT 203
Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
NL AF+VAE+ L I +LD ED+ T PDEK+I+TYV +FYH FS + R+
Sbjct: 204 NLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRIC 263
Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
KV+ E E+++E Y LASDLL WI +TI L +R N++ +QQ+L+ F YR +
Sbjct: 264 KVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLH 323
Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
KPPK QEK LE+ T+Q+++R +N+ + P +G++VSDIN AW LE+ E E L
Sbjct: 324 KPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLL 383
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF-GYDLAAVEAAKKKHEAIETD 470
NE+ R E+L+ LA +F +KA++ E W + ++ Q ++ L+ ++A KKHEA E+D
Sbjct: 384 NEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESD 443
Query: 471 TAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLAL 530
AA+++RV + +AQEL + +Y+D + AR I W L L Q RR+ LE T L
Sbjct: 444 LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL 503
Query: 531 QKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKHK-----LMEAD- 576
+ + +WM+ L + E++ L H+ L +AD
Sbjct: 504 LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADK 563
Query: 577 -----IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKA 631
+ I + K + + Y PQ I + H+ Q A
Sbjct: 564 ERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHA 623
Query: 632 QLEQSKRLWKFFW-EMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH-KAFEDELRGL 689
+ + ++RL K F + + WI+ K + + ++ L Q H + +E +
Sbjct: 624 RQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI--EMHGTLEDQLSHLRQYEKSIVNY 681
Query: 690 DAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN 744
++Q+ + + F + ++ + W+QL A + + + EN
Sbjct: 682 KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIA---RTINEVEN 733
Score = 55.8 bits (133), Expect = 4e-07
Identities = 90/467 (19%), Positives = 177/467 (37%), Gaps = 54/467 (11%)
Query: 531 QKLFQDMLH----SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKA 586
+KL D+L +I W++ + L + D + HK + Q +
Sbjct: 280 EKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFN 339
Query: 587 ITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSN----MAAGRKAQLEQSKRLW-K 641
L+ + + P + +++ D I++ C E++ +LE+ L K
Sbjct: 340 TLQTKLRLSNRPAFMPSEGRMVSD-INNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEK 398
Query: 642 FFWEMDEAESWIKEKEQIYSSLDYGK-DLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
F + E+W KE + DY L+ + L +KH+AFE +L +EQI A
Sbjct: 399 FRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIA 458
Query: 701 HGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAEN--------FFQFQGDA 752
+ + P + AR +++ QWD L L ++ L+ E + ++ A
Sbjct: 459 QELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRA 518
Query: 753 DDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESR----GVMEHLEQQ 805
W++ A L + + L H+ F L + ++ R G+ + +
Sbjct: 519 APFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKI 578
Query: 806 AQGF--------------PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
Q + P+E D +L R+ Q + + RQQ + L
Sbjct: 579 VQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRD---QALTEEHARQQHNER---LR 632
Query: 852 TVFG-ETDACELWMGEKEKWLA--EMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVN 908
FG + + W+ K + + +EM TLED +++ K + Q++G +
Sbjct: 633 KQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDH 692
Query: 909 -LAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
L +L+ ++ +H+ W+ T ++ V++ +
Sbjct: 693 QLIQEALIFD----NKHTNYTMEHIRVGWEQLLTTIARTINEVENQI 735
Score = 50.8 bits (120), Expect = 1e-05
Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 39/331 (11%)
Query: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHL 802
+F+ A +AW +L +D E AT +AL KKH+ F +L + +E +
Sbjct: 398 KFRQKASIHEAWTDGKEAMLRQKDY---ETATLSEIKALLKKHEAFESDLAAHQDRVEQI 454
Query: 803 EQQAQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQ------EALD-LYTVF 854
AQ E ++ DSP V R Q + + + + A R++ L+ E +D LY +
Sbjct: 455 AAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEY 514
Query: 855 GETDA-CELWMGEKEKWLAEMEMPDTLEDLEVV-----QHRFDILDQEMKTLMTQIDGVN 908
+ A WM + L + + T+E+++ + Q + + D + + L I G++
Sbjct: 515 AKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLA--ILGIH 572
Query: 909 LAANSLVESGHPRSREVKQYQ----DHLNTRWQAFQTLVSERREAV--DSALRVHN---- 958
+ +V++ H Y +N +W + LV R +A+ + A + HN
Sbjct: 573 NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLR 632
Query: 959 --YCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK-LSGLERDVAAIQARVDALE 1015
+ WI K +E + ++ G + Q L E+ + + ++D LE
Sbjct: 633 KQFGAQANVIGPWIQTK---MEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLE 689
Query: 1016 RESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
+ Q + ++ + +H+ W+ L
Sbjct: 690 GDHQLIQEALIFDNKHTNYTMEHIRVGWEQL 720
Score = 48.5 bits (114), Expect = 7e-05
Identities = 58/272 (21%), Positives = 105/272 (38%), Gaps = 45/272 (16%)
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
++ E +QLM++ + L S LE + R L+ E T H + D R
Sbjct: 268 VNQENEQLMED---YEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHK 324
Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
+Q L + ++ +LR + + S RM++ + + Q
Sbjct: 325 PPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLE-----------Q 373
Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
V E+G + L E R L+ L+ L + +Q S W + + +
Sbjct: 374 V----EKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEA------------WTDGKEAML 417
Query: 1502 QSADYGT-NLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
+ DY T L ++ +KK++ ++++ H RVE + Q+L E D + R
Sbjct: 418 RQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQ 477
Query: 1561 HLQSSWDRLREAAAGRLQRLRDANEAQQYYLD 1592
+ WD L Q+ R+A E + L+
Sbjct: 478 KICDQWDNL----GALTQKRREALERTEKLLE 505
Score = 48.1 bits (113), Expect = 9e-05
Identities = 66/269 (24%), Positives = 107/269 (39%), Gaps = 36/269 (13%)
Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
A++G +KAE N+ +V A Q QL++ +K +A DLL W+ I
Sbjct: 248 AFSGAQKAETAANRICKVLAVNQ--------ENEQLMEDYEK-----LASDLLEWIRRTI 294
Query: 1924 RQIETQ-------------ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLL 1970
+E + E RD + K + EI + L + +
Sbjct: 295 PWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFM 354
Query: 1971 QRQHQASEEIREK---LQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
+ + +I L+QV +E R ERL L E +F + AS+ EAW
Sbjct: 355 PSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAE--KFRQKASIHEAWTDG 412
Query: 2028 QEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPA 2086
+E L D+ T+ ++ L+K+HEAFE A+ +R + EL E + P+
Sbjct: 413 KEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQI-AAIAQELNELDYYDSPS 471
Query: 2087 EETGPQE--EEGETAGEAPVSHHAATERT 2113
Q+ ++ + G A ERT
Sbjct: 472 VNARCQKICDQWDNLGALTQKRREALERT 500
Score = 38.5 bits (88), Expect = 0.071
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 11/135 (8%)
Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWL--KHQAFVAELASHEGWLENIDA 1334
+ F Q W + K + Y+ A K L KH+AF ++LA+H+ +E I A
Sbjct: 397 EKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAA 456
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
++L + + V+ + + + WD L A T+++ + L L L+
Sbjct: 457 IAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAK 516
Query: 1387 THADLNKWI-SAMED 1400
A N W+ AMED
Sbjct: 517 RAAPFNNWMEGAMED 531
Score = 37.4 bits (85), Expect = 0.16
Identities = 59/311 (18%), Positives = 120/311 (38%), Gaps = 50/311 (16%)
Query: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
W K ++ L+ I A+ +K E D+AA Q RV+ + +Q+L +
Sbjct: 409 WTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYD 468
Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQL---------------QAF 1066
+ R + + + W L +++L+ E LL + QL +
Sbjct: 469 SPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGA 528
Query: 1067 LQDLDD---FQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKES 1123
++DL D I A E +LP+A++ GI +E+ +Y
Sbjct: 529 MEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYH----- 583
Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
V T+P + Q + G W+ + ++ R L + Q+ + ++
Sbjct: 584 ---VNMAGTNPYTTITPQEING---KWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGA 637
Query: 1184 LSN----------QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNK 1233
+N +E +E +LE + +R++E S+ N + K+ ++ ++
Sbjct: 638 QANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEK---SIVNYKPKI-DQLEGDHQ 693
Query: 1234 LVAEGNLYSDK 1244
L+ E ++ +K
Sbjct: 694 LIQEALIFDNK 704
Score = 36.2 bits (82), Expect = 0.35
Identities = 33/173 (19%), Positives = 74/173 (42%), Gaps = 16/173 (9%)
Query: 1895 RRTQLVD-TADKFRFFSMARDLLSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINA 1950
RR + +D A+KFR + + +W E+++RQ + + +S ++ L+K H+ +
Sbjct: 387 RRLERLDHLAEKFRQKASIHE--AWTDGKEAMLRQKDYETAT--LSEIKALLKKHEAFES 442
Query: 1951 EIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMN---EKWEARWERLRM 2007
++ + + L + + S + + Q++ + + +K ER
Sbjct: 443 DLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK 502
Query: 2008 LLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFE 2055
LLE ++++ A+ W+ L HT++ ++ L HE F+
Sbjct: 503 LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFK 555
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 416 bits (1070), Expect = e-115
Identities = 252/653 (38%), Positives = 367/653 (56%), Gaps = 38/653 (5%)
Query: 31 DNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIK 90
D D + E R L E Q+KTFT W NSHL + +I ++ +D R+G L+
Sbjct: 15 DEDEYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLML 74
Query: 91 LLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLI 150
LLEV+SGE LPKP +GKMR H + NV+KAL ++ + V L ++G+ +IVDGN ++ LG+I
Sbjct: 75 LLEVISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMI 134
Query: 151 WTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNA 210
WTIILRF IQDI V E SAK+ LLLWCQ KTA Y +VN+ NF +SWKDGL A
Sbjct: 135 WTIILRFAIQDISV------EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCA 188
Query: 211 LIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITY 269
LIH+HRPDLID+ KL + N+ A +AE+ L I +LD ED+ T PDE++I+TY
Sbjct: 189 LIHRHRPDLIDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTY 248
Query: 270 VVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRK 329
V FYH F+ + R+ KV+ E E+++E+Y LAS+LL WI +TI L +R
Sbjct: 249 VSCFYHAFAGAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRT 308
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
++ +Q++L+ F YR KPPK QEK LE+ T+Q+++R +N+ + P +GK+V
Sbjct: 309 PEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMV 368
Query: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETW-LSENQRLVAQD 448
SDI AW+ LE+AE E L NE+ R E+LE LA +F +KA+ ETW + Q L+ +D
Sbjct: 369 SDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKD 428
Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
L V A +KHEA E+D AA+++RV + +AQEL + +YHD + R I
Sbjct: 429 YESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICD 488
Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQ--DMLH---------SIDWMDEIKAHLLSAEFG 557
W L L Q RR+ LE ++KL + D LH +WM+ L
Sbjct: 489 QWDRLGTLTQKRREALE---RMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIV 545
Query: 558 KHLLEVEDLLQKHK-----LMEAD------IAIQGDKVKAITAATLKFTEGKGYQPCDPQ 606
+ E++ L+ H+ L EAD +AIQ + K I + ++ + Y
Sbjct: 546 HSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMD 605
Query: 607 VIQ---DRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEK 656
++ D++ L ++ R+ E+ +R +F + + WI+ K
Sbjct: 606 ELRTKWDKVKQLVPIRDQSLQEELARQHANERLRR--QFAAQANAIGPWIQNK 656
Score = 71.6 bits (174), Expect = 8e-12
Identities = 98/459 (21%), Positives = 179/459 (38%), Gaps = 44/459 (9%)
Query: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591
+L + + +I W++ K L + D +KHK + Q +
Sbjct: 292 ELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTK 351
Query: 592 LKFTEGKGYQPCDPQVIQD------RISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWE 645
L+ + + P + +++ D R+ E+ +EE R +LE KF +
Sbjct: 352 LRISNRPAFMPSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQK 409
Query: 646 MDEAESWIKEKEQIYSSLDY-GKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMV 704
E+W KEQI DY LT V L RKH+AFE +L +EQI A +
Sbjct: 410 ASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELN 469
Query: 705 ARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLK 756
+ R +++ QWD+L L ++ L+ E +F A
Sbjct: 470 ELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFN 529
Query: 757 AWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRG-------VMEHLEQQAQGF 809
W++ A L + ++L H+ F L E+ G + +E+ Q +
Sbjct: 530 NWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSY 589
Query: 810 PEEFRDS-PDVTHRLQALRELYQQVVAQADLRQQRLQEAL-------DLYTVF-GETDAC 860
S P T + LR + +V +R Q LQE L L F + +A
Sbjct: 590 NIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAI 649
Query: 861 ELWMGEKEKWLA--EMEMPDTLEDL--EVVQHRFDILDQEMKTLMTQIDGVN-LAANSLV 915
W+ K + +A +++ LED ++ Q+ +I++ K + +++G + L +LV
Sbjct: 650 GPWIQNKMEEIARSSIQITGALEDQMNQLKQYEHNIIN--YKNNIDKLEGDHQLIQEALV 707
Query: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSAL 954
++ +H+ W+ T ++ V++ +
Sbjct: 708 FD----NKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
Score = 58.9 bits (141), Expect = 5e-08
Identities = 62/303 (20%), Positives = 129/303 (42%), Gaps = 34/303 (11%)
Query: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
W K +++ L + A+ RK E D+AA Q RV+ + +Q+L +
Sbjct: 416 WAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHD 475
Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
++ R + + + W L +++L+ E LL + QL F + F W+
Sbjct: 476 AVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGA 535
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQ------GQ 1131
+ + + S+ E + L+ H K E DG + S ++ EKVIQ
Sbjct: 536 MEDLQDMFIVHSIEEIQSLITAHEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISS 595
Query: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSN----- 1186
++P + ++ L T W+ + ++ R +L + L Q + ++ A +N
Sbjct: 596 SNPYSTV---TMDELRTKWDKVKQLVPIRDQSLQEELARQHANERLRRQFAAQANAIGPW 652
Query: 1187 -----QEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241
+E + ++ +LE ++++E + + +NN DK ++ ++L+ E ++
Sbjct: 653 IQNKMEEIARSSIQITGALEDQMNQLKQYEHNIINYKNNIDK----LEGDHQLIQEALVF 708
Query: 1242 SDK 1244
+K
Sbjct: 709 DNK 711
Score = 50.8 bits (120), Expect = 1e-05
Identities = 58/266 (21%), Positives = 108/266 (40%), Gaps = 47/266 (17%)
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR------- 1384
++ E ++LM+E + L S+ LE + R L+ T EKT + D R
Sbjct: 275 VNQENERLMEE---YERLASELLEWIRRTIPWLENRTPEKTMQAMQKKLEDFRDYRRKHK 331
Query: 1385 ---LQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
+Q L + ++ +LR + + S +M++ + ++
Sbjct: 332 PPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQRLE------------ 379
Query: 1442 VPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLA 1501
E+G + L E R L+ LE L + +Q S+ ET W + +
Sbjct: 380 ---QAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTH-----------ET-WAYGKEQIL 424
Query: 1502 QSADY-GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
DY +L V+ ++K++ ++++ H RVE + Q+L E D ++ +R
Sbjct: 425 LQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQ 484
Query: 1561 HLQSSWDRL------REAAAGRLQRL 1580
+ WDRL R A R+++L
Sbjct: 485 KICDQWDRLGTLTQKRREALERMEKL 510
Score = 47.4 bits (111), Expect = 2e-04
Identities = 42/237 (17%), Positives = 100/237 (42%), Gaps = 11/237 (4%)
Query: 301 EKMIE-------KYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKP 353
EK++E +++ A+ W+E + L +S+ +Q + A ++ P
Sbjct: 508 EKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITAHEQFKAT-LP 566
Query: 354 PKFQEKGNLEVLLFTIQSRMRANNQKVYT--PHDGKLVSDINRAWESLEEAEYRRELALR 411
E+ ++ + ++ +++ N ++ + P+ + ++ W+ +++ R+ +L+
Sbjct: 567 EADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQLVPIRDQSLQ 626
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDT 471
EL RQ E+L R+F +A W+ +A+ + A+E + + E +
Sbjct: 627 EELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQI-TGALEDQMNQLKQYEHNI 685
Query: 472 AAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
Y+ + LE Q +++ D K ++I W L + +ET +
Sbjct: 686 INYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINEVETQI 742
Score = 42.4 bits (98), Expect = 0.005
Identities = 37/195 (18%), Positives = 81/195 (41%), Gaps = 21/195 (10%)
Query: 1880 EVSAAWQALLDACAG----------RRTQLVDTADKFRFFSMARDLLSW-MESIIRQIET 1928
+++ AWQ L A G R +L A+KFR + + ++ E I+ Q +
Sbjct: 370 DIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDY 429
Query: 1929 QERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVM 1988
+ ++ V L++ H+ +++ + + L + + + + ++ Q++
Sbjct: 430 ESA--SLTEVRALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKIC 487
Query: 1989 S---RRKEMNEKWEARWERLRMLLEVC-----QFSRDASVAEAWLIAQEPYLASGDFGHT 2040
R + +K ER+ LLE +F++ A+ W+ L H+
Sbjct: 488 DQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHS 547
Query: 2041 VDSVEKLIKRHEAFE 2055
++ ++ LI HE F+
Sbjct: 548 IEEIQSLITAHEQFK 562
Score = 40.0 bits (92), Expect = 0.024
Identities = 50/218 (22%), Positives = 93/218 (42%), Gaps = 33/218 (15%)
Query: 1865 AYAG-EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESII 1923
A+AG E+AE N+ +V A Q +L++ ++ +A +LL W+ I
Sbjct: 255 AFAGAEQAETAANRICKVLAVNQ--------ENERLMEEYER-----LASELLEWIRRTI 301
Query: 1924 RQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEE---- 1979
+E + + + +++ ++ + + + LE+ + LQ + + S
Sbjct: 302 PWLENRTPEKTMQAMQKKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFM 361
Query: 1980 -IREKLQQVMS---RRKEMNEKWEARW--------ERLRMLLEVCQFSRDASVAEAWLIA 2027
K+ ++ +R E EK W ERL L E +F + AS E W
Sbjct: 362 PSEGKMVSDIAGAWQRLEQAEKGYEEWLLNEIRRLERLEHLAE--KFRQKASTHETWAYG 419
Query: 2028 QEPYLASGDF-GHTVDSVEKLIKRHEAFEKSTASWAER 2064
+E L D+ ++ V L+++HEAFE A+ +R
Sbjct: 420 KEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDR 457
Score = 36.6 bits (83), Expect = 0.27
Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 11/135 (8%)
Query: 1277 QNFLQNCQELTLWI--NDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDA 1334
+ F Q W +++L +D + KH+AF ++LA+H+ +E I A
Sbjct: 404 EKFRQKASTHETWAYGKEQILLQKDYESASLTEVRALLRKHEAFESDLAAHQDRVEQIAA 463
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
++L + V+ + + + WD L T+++ + L L L+
Sbjct: 464 IAQELNELDYHDAVNVNDRCQKICDQWDRLGTLTQKRREALERMEKLLETIDQLHLEFAK 523
Query: 1387 THADLNKWI-SAMED 1400
A N W+ AMED
Sbjct: 524 RAAPFNNWMEGAMED 538
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 409 bits (1052), Expect = e-113
Identities = 248/638 (38%), Positives = 358/638 (56%), Gaps = 32/638 (5%)
Query: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
E Q+KTFT W NSHL + +I ++ +D R+G L+ LLEV+SGE LP+P KGKMR H
Sbjct: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
Query: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EE 157
Query: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
SAK+ LLLWCQ KTA Y +VNV NF +SWKDGLA ALIH+HRPDLID+ KL+ +
Sbjct: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
Query: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
NL AF VAE+ L I +LD ED+ T PDEK+I+TYV FYH F+ + R+
Sbjct: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
Query: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
KV+ E EK++E+Y LAS+LL WI +T+ L +R S++ +Q++L+ F YR +
Sbjct: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
Query: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
KPP+ QEK LE+ T+Q+++R +++ + P +GKLVSDI AW LE+ E E L
Sbjct: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
Query: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYD---LAAVEAAKKKHEAIE 468
+E+ R ++L+ LA +F +KA++ E W + +++Q + YD L V A ++HEA E
Sbjct: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRD--YDSALLQEVRALLRRHEAFE 455
Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
+D AA+++RV + LAQEL + +YH+ + +R I W L L Q RR LE
Sbjct: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515
Query: 529 ALQKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKH-----KLMEA 575
L + + +W+D L + E + LL H L EA
Sbjct: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575
Query: 576 D------IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
D + IQG+ K L+ Y PQ I + + +
Sbjct: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEE 635
Query: 630 KAQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYG 666
A+ + ++RL + F + + WI+ K + L G
Sbjct: 636 LARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAG 673
Score = 54.7 bits (130), Expect = 1e-06
Identities = 66/303 (21%), Positives = 130/303 (42%), Gaps = 34/303 (11%)
Query: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
W K +++ L + A+ R+ E D+AA Q RV+ + +Q+L + +
Sbjct: 423 WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHE 482
Query: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
+ R + + + W L + +L+ E LL + QLQ F + F WL
Sbjct: 483 AASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGA 542
Query: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQG------Q 1131
+ + + S+ E + LL H K E D + + ++ +K+ Q
Sbjct: 543 VEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCS 602
Query: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ--EY 1189
T+P Y+ L + ++T W+ + ++ SR TL + L Q+ + ++ A +N +
Sbjct: 603 TNP-YITLSP--QDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPW 659
Query: 1190 TLAHLEP--------PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241
A +E SLE AG+R+ E + + + N D+ ++ ++L+ E ++
Sbjct: 660 IQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR----LEGDHQLLQESLVF 715
Query: 1242 SDK 1244
+K
Sbjct: 716 DNK 718
Score = 52.8 bits (125), Expect = 4e-06
Identities = 69/338 (20%), Positives = 126/338 (37%), Gaps = 21/338 (6%)
Query: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591
+L + + ++ W++ + + L + D + HK Q +
Sbjct: 299 ELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTK 358
Query: 592 LKFTEGKGYQPCDPQVIQDRISH---LEQCFEELSNMAAGRKAQLEQSKRLW-KFFWEMD 647
L+ + + P + +++ D + LEQ + + +L++ + L KF +
Sbjct: 359 LRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKAS 418
Query: 648 EAESWIKEKEQIYSSLDYGKDLTS-VLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVAR 706
E+W + KE++ S DY L V L R+H+AFE +L +E I A +
Sbjct: 419 LHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNEL 478
Query: 707 KQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLKAW 758
+ +R + + QWD L L + L+ E +F A W
Sbjct: 479 DYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNW 538
Query: 759 LQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESRGVMEHLEQQAQGFPEEF-- 813
L A L + T++L H F L E + RG + ++ + Q + +
Sbjct: 539 LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGL 598
Query: 814 ---RDSPDVTHRLQALRELYQQVVAQADLRQQRLQEAL 848
+P +T Q + + V R Q LQE L
Sbjct: 599 RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL 636
Score = 49.3 bits (116), Expect = 4e-05
Identities = 79/338 (23%), Positives = 137/338 (40%), Gaps = 45/338 (13%)
Query: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDE-GATRALGKKHKDFLEELEESRGVMEHLEQQ 805
+F+ A +AW + +LS D RAL ++H+ F +L + +EH+
Sbjct: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAAL 471
Query: 806 AQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELW 863
AQ E ++ ++ V R QA+ + + + L Q+R ++AL+ ET D +L
Sbjct: 472 AQELNELDYHEAASVNSRCQAICDQWDNL---GTLTQKR-RDALERMEKLLETIDQLQLE 527
Query: 864 MGEK----EKWL--AEMEMPDT--LEDLEVVQHRFDILDQEMKTLMTQ------IDGVNL 909
+ WL A ++ D + +E Q DQ TL I G+
Sbjct: 528 FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQG 587
Query: 910 AANSLVESGHPRSREVKQY-----QDHLNTRWQAFQTLVSER---------REAVDSALR 955
+ ++ R Y QD +NT+W + LV R R+ V+ LR
Sbjct: 588 EIQKICQTYGLRPCSTNPYITLSPQD-INTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646
Query: 956 VHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGL---ERDVAAIQARVD 1012
+ WI K VE L LAG +++ +++GL E+++ + +D
Sbjct: 647 -RQFAAQANAIGPWIQAK---VEEVGRLAAGLAG--SLEEQMAGLRQQEQNIINYKTNID 700
Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
LE + Q L +S + +H+ W+ L S+
Sbjct: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI 738
Score = 45.4 bits (106), Expect = 6e-04
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 12/142 (8%)
Query: 1033 GQRQKHLEELWQGLQQSLQGQED-LLGEVSQLQ-------AFLQDLDDFQAWLSITQKAV 1084
G+ + W+GL+Q +G ED LL E+ +LQ F Q +AW ++ +
Sbjct: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
Query: 1085 ASEDMPES-LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTD-PEYLLLGQR 1142
+ D + L E LL++H + ++ HQD + + +++ + D E + R
Sbjct: 432 SQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL--NELDYHEAASVNSR 489
Query: 1143 LEGLDTGWNALGRMWESRSHTL 1164
+ + W+ LG + + R L
Sbjct: 490 CQAICDQWDNLGTLTQKRRDAL 511
Score = 42.4 bits (98), Expect = 0.005
Identities = 32/138 (23%), Positives = 60/138 (43%), Gaps = 7/138 (5%)
Query: 1456 IEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL-QTVQ 1514
+EK + D L RR ++L+ K + L + W + + DY + L Q V+
Sbjct: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVR 445
Query: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
+++++ ++++ H RVE + Q+L E + + R + WD L
Sbjct: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT- 504
Query: 1575 GRLQRLRDANEAQQYYLD 1592
Q+ RDA E + L+
Sbjct: 505 ---QKRRDALERMEKLLE 519
Score = 40.0 bits (92), Expect = 0.024
Identities = 24/65 (36%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 2001 RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTV-DSVEKLIKRHEAFEKSTA 2059
R +RL+ L E +F + AS+ EAW +E L+ D+ + V L++RHEAFE A
Sbjct: 402 RLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLA 459
Query: 2060 SWAER 2064
+ +R
Sbjct: 460 AHQDR 464
Score = 38.1 bits (87), Expect = 0.093
Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 11/135 (8%)
Query: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEA--RNLHNKWLKHQAFVAELASHEGWLENIDA 1334
+ F Q W K YD A + + +H+AF ++LA+H+ +E+I A
Sbjct: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
Query: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
++L + A V+ + +A+ WD L T+++ L L+L+
Sbjct: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
Query: 1387 THADLNKWI-SAMED 1400
A N W+ A+ED
Sbjct: 531 RAAPFNNWLDGAVED 545
Score = 35.0 bits (79), Expect = 0.79
Identities = 27/146 (18%), Positives = 62/146 (42%), Gaps = 6/146 (4%)
Query: 810 PEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
P E + D+ + + L ++ Y+ + R QRLQ + + + E W
Sbjct: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQ--KASLHEAWTRG 426
Query: 867 KEKWLAEMEMPDTL-EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREV 925
KE+ L++ + L +++ + R + + ++ +++ + A L E + + V
Sbjct: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
Query: 926 KQYQDHLNTRWQAFQTLVSERREAVD 951
+ +W TL +RR+A++
Sbjct: 487 NSRCQAICDQWDNLGTLTQKRRDALE 512
Score = 35.0 bits (79), Expect = 0.79
Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 14/133 (10%)
Query: 1667 QVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL-EQWISEKELVASSPEMGQDFDHV 1725
QV+K Y +D R+L+ + HL + R+ L E W KE + S +D+D
Sbjct: 387 QVEKGY---EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQ----RDYDSA 439
Query: 1726 TL-----LRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
L L + F + A Q+RV+++ A + L + + EAA++ + + W
Sbjct: 440 LLQEVRALLRRHEAFESDLAA-HQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498
Query: 1781 DLLELIDTRMQLL 1793
+L L R L
Sbjct: 499 NLGTLTQKRRDAL 511
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 376 bits (966), Expect = e-103
Identities = 532/2209 (24%), Positives = 910/2209 (41%), Gaps = 280/2209 (12%)
Query: 42 RSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLP 101
++ I +L DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP
Sbjct: 8 QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
Query: 102 KPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQD 161
+ KG+MR H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI D
Sbjct: 68 RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
Query: 162 IVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLID 221
I V Q E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID
Sbjct: 127 IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
Query: 222 FDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMK 281
+K+ NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++
Sbjct: 185 MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
Query: 282 VLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQL 341
+ +G R A E + ++Y L LL W+ R+F +S ++
Sbjct: 245 DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
Query: 342 QAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEE 401
F ++ +E P K +K + + +++ ++A KV G D+ + W L
Sbjct: 297 SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
Query: 402 AEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461
A RE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 354 AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
Query: 462 KKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILR 508
++ +E D + +R L + Q L K+ H Q + + R + LR
Sbjct: 411 QRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469
Query: 509 L--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHL 560
L Q LQS ++R E + + QD+L W++E + + AE+G L
Sbjct: 470 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDL 526
Query: 561 LEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFE 620
VE L H+ + I K++ + EG+ P +D + L+ +
Sbjct: 527 PSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYA 580
Query: 621 ELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHK 680
+L N + KA+L + L F + W+ EKE+ D+ T++ + +
Sbjct: 581 KLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637
Query: 681 AFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQ 740
A EL + ++++ ++ P +E+ + QW + L + +L+
Sbjct: 638 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
Query: 741 DAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESR 796
+ +FQF D + + LQ L D AT L + +D E+L E +
Sbjct: 698 ENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
Query: 797 GVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGE 856
G + L ++A+ + P H ++ L +A D +Q + +
Sbjct: 757 GHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHK 802
Query: 857 TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE 916
D C+L +G + K L + G A S+
Sbjct: 803 GDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCF 834
Query: 917 SGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKV 976
P ++E ++ L + QA TL H VD + W
Sbjct: 835 LVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------- 874
Query: 977 VESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK- 1029
+ L RD+ I +A R L E+ A +++ A R+SQ PE +
Sbjct: 875 ----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 930
Query: 1030 ---EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVA 1085
+ G H ++L Q L+Q Q E S+ Q + +L D + L + + V
Sbjct: 931 MAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVH 983
Query: 1086 SEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQ 1141
+P E E Q + + + E++G R+ EKV+ + P L
Sbjct: 984 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1043
Query: 1142 RLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPD 1198
LE LG++ + RS + L + + + AE +L E L +
Sbjct: 1044 ELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1097
Query: 1199 S----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKE 1247
+ LEA +A ++K E + + RD++ + G +L E ++ ++ +E
Sbjct: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
Query: 1248 KVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS-- 1301
+V + +R + + + + +E L R +L+ + ++ L W+ D + +
Sbjct: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAM 1214
Query: 1302 -YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHR 1359
+++ + + + QA + E+ H +E KQ ++ K LV+ K +
Sbjct: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL--- 1271
Query: 1360 LWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDL 1411
E A+ +K + S + S + L+TH +++I + + LR + + L
Sbjct: 1272 ---EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328
Query: 1412 TSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470
R + + E + + K+ +L E AQ + E +++R + E + R
Sbjct: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRRE 1383
Query: 1471 KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH 1530
+ +++ + K I +L ++L + A+ + + + ++ EI
Sbjct: 1384 EAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
Query: 1531 TPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587
++E QRG + ++A ++ E + Q +RLR QR R A
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647
+ A EAEA +Q +E+ E A +R LRQ A + R ++ A
Sbjct: 1496 ASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETA 1548
Query: 1648 Q-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-D 1701
Q L S E+ +L+ + + + + + EE +R+ + + + E + +
Sbjct: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608
Query: 1702 LEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVD 1748
LE+W + E VA + Q + R+ R E A+ Q +
Sbjct: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
Query: 1749 NVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+R + G ++ AE + E LLE R+Q AA+ R
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
L E + E L AS A + + E+ L + +F+++A
Sbjct: 1729 Q--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
Query: 1862 LQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRF 1908
A E+A+ + +E +A +A + A G T+L A +K
Sbjct: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1840
Query: 1909 FSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGES 1968
R L R++E Q E L + + ++E+E R K L E
Sbjct: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVED 1893
Query: 1969 LLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQ 2028
L+++ Q EEI L+ + + E R+R E S++ + EA A+
Sbjct: 1894 TLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---AR 1949
Query: 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERP 2085
+ LA+ + ++ E++ K A E++ +R AALE+ L+ K R++ ER
Sbjct: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERA 2006
Query: 2086 AEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+E+ Q + A EA A E+ ++ + ++LQ E S
Sbjct: 2007 EQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1240
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1241 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1298
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1299 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1358
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1359 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1477 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1527
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1702
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1703 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1758
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 1996
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2177 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2226
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2282
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2323
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2324 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2377
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2378 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2415
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2466
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2527 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2584 RAALAHS 2590
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1308
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1417
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1418 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1474 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1513
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1514 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1556
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1557 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1598
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1599 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1650 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1695 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1867
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2035
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2086
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2267 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2320
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2378
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2379 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2424
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2425 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2479
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2540 AEEGVRRKQEELQQLEQQRRQQEEL 2564
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1766
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1827 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1881
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1933
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1934 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1990
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 1991 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2044
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2045 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2160
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2161 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2211
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2212 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2269 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2438
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2439 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2548
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2549 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2594
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1978
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2034
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2035 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2144
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2145 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2186
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2187 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2303 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2471
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2532 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2590 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2650 LAQGHTTVDEL 2660
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1010 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1069
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1070 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1129
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1189
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1190 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1249
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1306
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1307 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1408
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1409 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1456
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1457 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1511
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1512 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1564
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1621
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1737
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1792
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1793 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1845
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1846 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2083
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2084 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2137
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2138 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2183 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2220
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2277
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2338 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2397
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2398 TELATQEKVT 2407
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 375 bits (964), Expect = e-103
Identities = 534/2210 (24%), Positives = 912/2210 (41%), Gaps = 281/2210 (12%)
Query: 41 ERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML 100
ER+ I+ +ADER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ L
Sbjct: 57 ERAVIR-IADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 115
Query: 101 PKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQ 160
P+ KG+MR H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI
Sbjct: 116 PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 174
Query: 161 DIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLI 220
DI V Q E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LI
Sbjct: 175 DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 232
Query: 221 DFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKM 280
D +K+ NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++
Sbjct: 233 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 292
Query: 281 KVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQ 340
+ +G R A E + ++Y L LL W+ R+F +S ++
Sbjct: 293 PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 344
Query: 341 LQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLE 400
F ++ +E P K +K + + +++ ++A KV G D+ + W L
Sbjct: 345 WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 401
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
A RE LR+E R E L+++ + +A + E L++ L+ D L A
Sbjct: 402 VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 458
Query: 461 KKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNIL 507
++ +E D + +R L + Q L K+ H Q + + R + L
Sbjct: 459 PQRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNL 517
Query: 508 RL--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKH 559
RL Q LQS ++R E + + QD+L W++E + + AE+G
Sbjct: 518 RLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVD 574
Query: 560 LLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCF 619
L VE L H+ + I K++ + EG+ P +D + L+ +
Sbjct: 575 LPSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQY 628
Query: 620 EELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKH 679
+L N + KA+L + L F + W+ EKE+ D+ T++ + +
Sbjct: 629 AKLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 685
Query: 680 KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNL 739
A EL + ++++ ++ P +E+ + QW + L + +L
Sbjct: 686 SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 745
Query: 740 QDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEES 795
++ +FQF D + + LQ L D AT L + +D E+L E
Sbjct: 746 KENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEY 804
Query: 796 RGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFG 855
+G + L ++A+ + P H ++ L +A D +Q +
Sbjct: 805 KGHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVH 850
Query: 856 ETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLV 915
+ D C+L +G + K L + G A S+
Sbjct: 851 KGDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVC 882
Query: 916 ESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTK 975
P ++E ++ L + QA TL H VD + W
Sbjct: 883 FLVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------ 923
Query: 976 VVESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK 1029
+ L RD+ I +A R L E+ A +++ A R+SQ PE +
Sbjct: 924 -----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDR 978
Query: 1030 ----EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAV 1084
+ G H ++L Q L+Q Q E S+ Q + +L D + L + + V
Sbjct: 979 LMAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTV 1031
Query: 1085 ASEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLG 1140
+P E E Q + + + E++G R+ EKV+ + P L
Sbjct: 1032 HRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR 1091
Query: 1141 QRLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP 1197
LE LG++ + RS + L + + + AE +L E L +
Sbjct: 1092 SELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAV 1145
Query: 1198 DS----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIK 1246
+ LEA +A ++K E + + RD++ + G +L E ++ ++ +
Sbjct: 1146 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR 1205
Query: 1247 EKVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS- 1301
E+V + +R + + + + +E L R +L+ + ++ L W+ D + +
Sbjct: 1206 ERVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQA 1262
Query: 1302 --YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALH 1358
+++ + + + QA + E+ H +E KQ ++ K LV+ K +
Sbjct: 1263 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-- 1320
Query: 1359 RLWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKD 1410
E A+ +K + S + S + L+TH +++I + + LR + +
Sbjct: 1321 ----EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEER 1376
Query: 1411 LTSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
L R + + E + + K+ +L E AQ + E +++R + E + R
Sbjct: 1377 LAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRR 1431
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
+ +++ + K I +L ++L + A+ + + + ++ EI
Sbjct: 1432 EEAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1483
Query: 1530 HTPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEA 1586
++E QRG + ++A ++ E + Q +RLR QR R A
Sbjct: 1484 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR 1646
+ A EAEA +Q +E+ E A +R LRQ A + R ++
Sbjct: 1544 LASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALET 1596
Query: 1647 AQ-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD- 1700
AQ L S E+ +L+ + + + + + EE +R+ + + + E +
Sbjct: 1597 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1656
Query: 1701 DLEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERV 1747
+LE+W + E VA + Q + R+ R E A+ Q +
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
Query: 1748 DNVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLH 1800
+R + G ++ AE + E LLE R+Q AA+
Sbjct: 1717 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 1801 RYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVAT 1860
R L E + E L AS A + + E+ L + +F+++A
Sbjct: 1777 RQ--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Query: 1861 RLQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFR 1907
A E+A+ + +E +A +A + A G T+L A +K
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888
Query: 1908 FFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGE 1967
R L R++E Q E L + + ++E+E R K L E
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVE 1941
Query: 1968 SLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIA 2027
L+++ Q EEI L+ + + E R+R E S++ + EA A
Sbjct: 1942 DTLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---A 1997
Query: 2028 QEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAER 2084
++ LA+ + ++ E++ K A E++ +R AALE+ L+ K R++ ER
Sbjct: 1998 RQRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRER 2054
Query: 2085 PAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+E+ Q + A EA A E+ ++ + ++LQ E S
Sbjct: 2055 AEQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1178 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1237
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1238 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1289
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1290 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1347
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1348 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1407
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1408 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1465
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1525
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1526 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1576
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1577 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1636
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1696
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1697 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1751
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1752 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1807
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2045
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 2046 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2105
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2106 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2165
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2166 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2226 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2275
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2276 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2331
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2332 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2372
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2373 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2426
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2427 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2464
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2515
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2576 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2633 RAALAHS 2639
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1357
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1358 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1417
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1418 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1466
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1467 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1522
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1523 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1562
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1563 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1605
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1606 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1647
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1648 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1699 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1743
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1744 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1798
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1799 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1858
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1859 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1916
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1917 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1976
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1977 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2036
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 2037 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2084
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2135
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2195
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2316 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2369
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2370 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2427
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2428 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2473
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2474 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2528
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2588
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2589 AEEGVRRKQEELQQLEQQRRQQEEL 2613
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1699 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1758
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1815
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1816 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1875
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1876 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1930
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1982
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1983 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2039
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 2040 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2093
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2094 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2150
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2209
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2210 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2260
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2261 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2318 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2487
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2488 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2597
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2598 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2643
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1972 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2027
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 2028 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2083
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2084 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2138
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2193
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2194 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2235
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2236 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2351
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2352 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2520
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2580
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2581 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2638
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2639 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2699 LAQGHTTVDEL 2709
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1059 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1118
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1119 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1178
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1179 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1238
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1239 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1298
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1299 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1355
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1356 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1402
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1457
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1458 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1505
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1506 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1560
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1561 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1613
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1614 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1670
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1730
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1731 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1786
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1841
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1842 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1894
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1895 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1952
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1953 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2132
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2133 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2186
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2187 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2231
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2232 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2269
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2326
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2327 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2386
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2387 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2446
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2447 TELATQEKVT 2456
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 374 bits (961), Expect = e-103
Identities = 531/2206 (24%), Positives = 908/2206 (41%), Gaps = 280/2206 (12%)
Query: 45 IKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPT 104
+K + DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+
Sbjct: 1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE- 59
Query: 105 KGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVV 164
KG+MR H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V
Sbjct: 60 KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119
Query: 165 QTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDK 224
Q E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K
Sbjct: 120 SGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNK 177
Query: 225 LKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLA 284
+ NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ +
Sbjct: 178 VYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ 237
Query: 285 VEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAF 344
+G R A E + ++Y L LL W+ R+F +S ++ F
Sbjct: 238 -DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQF 289
Query: 345 STYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEY 404
++ +E P K +K + + +++ ++A KV G D+ + W L A
Sbjct: 290 LKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAIL 346
Query: 405 RRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKH 464
RE LR+E R E L+++ + +A + E L++ L+ D L A ++
Sbjct: 347 EREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRA 403
Query: 465 EAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL-- 509
+E D + +R L + Q L K+ H Q + + R + LRL
Sbjct: 404 GEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 462
Query: 510 ------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
Q LQS ++R E + + QD+L W++E + + AE+G L V
Sbjct: 463 GVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSV 519
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
E L H+ + I K++ + EG+ P +D + L+ + +L
Sbjct: 520 EAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLL 573
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
N + KA+L + L F + W+ EKE+ D+ T++ + + A
Sbjct: 574 NSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALM 630
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAE 743
EL + ++++ ++ P +E+ + QW + L + +L++
Sbjct: 631 RELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENA 690
Query: 744 NFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVM 799
+FQF D + + LQ L D AT L + +D E+L E +G +
Sbjct: 691 AYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHL 749
Query: 800 EHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDA 859
L ++A+ + P H ++ L +A D +Q + + D
Sbjct: 750 SGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDE 795
Query: 860 CELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGH 919
C+L +G + K L + G A S+
Sbjct: 796 CQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVP 827
Query: 920 PRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVES 979
P ++E ++ L + QA TL H VD + W
Sbjct: 828 PPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW---------- 864
Query: 980 TKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK---- 1029
+ L RD+ I +A R L E+ A +++ A R+SQ PE +
Sbjct: 865 -QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 923
Query: 1030 EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASED 1088
+ G H ++L Q L+Q Q E S+ Q + +L D + L + + V
Sbjct: 924 REYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLR 976
Query: 1089 MP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLE 1144
+P E E Q + + + E++G R+ EKV+ + P L LE
Sbjct: 977 LPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE 1036
Query: 1145 GLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS-- 1199
LG++ + RS + L + + + AE +L E L + +
Sbjct: 1037 ------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATL 1090
Query: 1200 --LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQ 1250
LEA +A ++K E + + RD++ + G +L E ++ ++ +E+V
Sbjct: 1091 PELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 1251 LIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YD 1303
+ +R + + + + +E L R +L+ + ++ L W+ D + +
Sbjct: 1151 QLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1207
Query: 1304 EARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWD 1362
+++ + + + QA + E+ H +E KQ ++ K LV+ K +
Sbjct: 1208 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------ 1261
Query: 1363 ELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSV 1414
E A+ +K + S + S + L+TH +++I + + LR + + L
Sbjct: 1262 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1321
Query: 1415 NRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
R + + E + + K+ +L E AQ + E +++R + E + R +
Sbjct: 1322 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAA 1376
Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPR 1533
+++ + K I +L ++L + A+ + + + ++ EI +
Sbjct: 1377 VDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 1534 VEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYY 1590
+E QRG + ++A ++ E + Q +RLR QR R A
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 1591 LDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-- 1648
+ A EAEA +Q +E+ E A +R LRQ A + R ++ AQ
Sbjct: 1489 VKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRS 1541
Query: 1649 ---GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQ 1704
L S E+ +L+ + + + + + EE +R+ + + + E + +LE+
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 1705 W----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVN 1751
W + E VA + Q + R+ R E A+ Q +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 1752 AFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFY 1804
+R + G ++ AE + E LLE R+Q AA+ R
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ-- 1719
Query: 1805 TGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQT 1864
L E + E L AS A + + E+ L + +F+++A
Sbjct: 1720 ------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 1865 AYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSM 1911
A E+A+ + +E +A +A + A G T+L A +K
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833
Query: 1912 ARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
R L R++E Q E L + + ++E+E R K L E L+
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLR 1886
Query: 1972 RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPY 2031
++ Q EEI L+ + + E R+R E S++ + EA A++
Sbjct: 1887 QRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQ 1942
Query: 2032 LASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEE 2088
LA+ + ++ E++ K A E++ +R AALE+ L+ K R++ ER +E
Sbjct: 1943 LAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQE 1999
Query: 2089 TGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+ Q + A EA A E+ ++ + ++LQ E S
Sbjct: 2000 SARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1119 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1178
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1179 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1230
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1231 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1288
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1289 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1348
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1349 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1406
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1407 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1466
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1467 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1517
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1518 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1577
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1637
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1638 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1692
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1693 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1748
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 1986
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 1987 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2046
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2047 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2106
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2107 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2167 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2216
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2217 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2272
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2273 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2313
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2314 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2367
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2368 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2405
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2456
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2457 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2517 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2574 RAALAHS 2580
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1298
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1299 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1358
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1359 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1407
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1408 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1463
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1464 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1503
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1504 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1546
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1547 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1588
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1589 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1640 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1684
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1685 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1739
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1740 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1799
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1800 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1857
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1858 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1917
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1918 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1977
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 1978 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2025
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2076
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2136
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2196
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2256
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2257 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2310
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2311 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2368
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2369 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2414
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2415 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2469
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2529
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2530 AEEGVRRKQEELQQLEQQRRQQEEL 2554
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1640 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1699
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1756
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1757 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1816
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1817 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1871
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1872 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1923
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1924 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1980
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 1981 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2034
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2035 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2091
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2150
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2151 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2201
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2202 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2259 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2428
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2429 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2538
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2539 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2584
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1913 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1968
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 1969 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2024
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2025 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2079
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2134
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2135 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2176
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2177 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2292
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2293 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2461
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2521
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2522 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2579
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2580 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2639
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2640 LAQGHTTVDEL 2650
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1000 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1059
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1060 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1119
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1120 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1179
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1180 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1239
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1240 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1296
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1297 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1343
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1398
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1399 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1446
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1447 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1501
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1502 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1554
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1555 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1611
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1671
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1672 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1727
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1782
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1783 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1835
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1836 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1893
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1894 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2013
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2073
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2074 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2127
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2128 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2172
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2173 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2210
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2267
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2268 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2327
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2328 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2387
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2388 TELATQEKVT 2397
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 373 bits (958), Expect = e-103
Identities = 534/2221 (24%), Positives = 913/2221 (41%), Gaps = 281/2221 (12%)
Query: 30 LDNDNSSARLFERSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLI 89
L ++ + +E R K DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI
Sbjct: 5 LPDEQDFIQAYEEVREK-YKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLI 63
Query: 90 KLLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGL 149
LLEVLSG+ LP+ KG+MR H L+NV AL +L+ ++V L N+ + DI DGN +L LGL
Sbjct: 64 SLLEVLSGDSLPRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGL 122
Query: 150 IWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFN 209
IWTIIL FQI DI V Q E +AK+ LLLW Q GY + NFTSSW+DG FN
Sbjct: 123 IWTIILHFQISDIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFN 180
Query: 210 ALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITY 269
A+IH+H+P LID +K+ NL+ AF+VAER LG+ LLDPEDV PDEKSIITY
Sbjct: 181 AIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITY 240
Query: 270 VVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRK 329
V + Y ++ + +G R A E + ++Y L LL W+ R+
Sbjct: 241 VSSLYDAMPRVPDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERR 292
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLV 389
F +S ++ F ++ +E P K +K + + +++ ++A KV G
Sbjct: 293 FPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHP 349
Query: 390 SDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDN 449
D+ + W L A RE LR+E R E L+++ + +A + E L++ L+ D
Sbjct: 350 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD- 408
Query: 450 FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ------------- 496
L A ++ +E D + +R L + Q L K+ H Q
Sbjct: 409 --VRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHE 465
Query: 497 KRITARKDNILRL--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIK 548
+ + R + LRL Q LQS ++R E + + QD+L W++E +
Sbjct: 466 RLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQ 522
Query: 549 AHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVI 608
+ AE+G L VE L H+ + I K++ + EG+ P
Sbjct: 523 HRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAY 576
Query: 609 QDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKD 668
+D + L+ + +L N + KA+L + L F + W+ EKE+ D+
Sbjct: 577 RDCLGRLDLQYAKLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 633
Query: 669 LTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQL 728
T++ + + A EL + ++++ ++ P +E+ + QW +
Sbjct: 634 NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 693
Query: 729 KDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKK 784
L + +L++ +FQF D + + LQ L D AT L +
Sbjct: 694 LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQD 752
Query: 785 HKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRL 844
+D E+L E +G + L ++A+ + P H ++ L +A D +Q
Sbjct: 753 AQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--- 803
Query: 845 QEALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQI 904
+ + D C+L +G + K L +
Sbjct: 804 -----VEVTVHKGDECQL-VGPAQ-------------------------PSHWKVLSS-- 830
Query: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
G A S+ P ++E ++ L + QA TL H VD +
Sbjct: 831 SGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMK 877
Query: 965 ETSKWITDKTKVVESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERES 1018
W + L RD+ I +A R L E+ A +++ A R+S
Sbjct: 878 SLLAW-----------QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDS 926
Query: 1019 QQLMDSHPEQK----EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQ 1074
Q PE + + G H ++L Q L+Q Q E S+ Q + +L D +
Sbjct: 927 QDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIR 979
Query: 1075 AWLSITQ-KAVASEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ- 1129
L + + V +P E E Q + + + E++G R+ EKV+
Sbjct: 980 LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAL 1039
Query: 1130 GQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSN 1186
+ P L LE LG++ + RS + L + + + AE +L
Sbjct: 1040 PEPSPAAPTLRSELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRA 1093
Query: 1187 QEYTLAHLEPPDS----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV--- 1235
E L + + LEA +A ++K E + + RD++ + G +L
Sbjct: 1094 HEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRH 1153
Query: 1236 AEGNLYSDKIKEKVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWIN 1291
E ++ ++ +E+V + +R + + + + +E L R +L+ + ++ L W+
Sbjct: 1154 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQ 1210
Query: 1292 DKLLTSQDVS---YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFT 1347
D + + +++ + + + QA + E+ H +E KQ ++ K
Sbjct: 1211 DARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1270
Query: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAME 1399
LV+ K + E A+ +K + S + S + L+TH +++I +
Sbjct: 1271 QLVTYKAQL------EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 1400 DQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEK 1458
+ LR + + L R + + E + + K+ +L E AQ + E +++
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQ 1381
Query: 1459 RFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMK 1518
R + E + R + +++ + K I +L ++L + A+ + + +
Sbjct: 1382 RMQE--EVVRREEAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAER 1431
Query: 1519 KNQTLQNEILGHTPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAG 1575
++ EI ++E QRG + ++A ++ E + Q +RLR
Sbjct: 1432 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1491
Query: 1576 RLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVED 1635
QR R A + A EAEA +Q +E+ E A +R LRQ A +
Sbjct: 1492 ESQRKRQAEVELASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVE 1544
Query: 1636 YGRNIKQLASRAQ-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMY 1690
R ++ AQ L S E+ +L+ + + + + + EE +R+ +
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604
Query: 1691 HLFQLKRETD-DLEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFA 1736
+ + E + +LE+W + E VA + Q + R+ R
Sbjct: 1605 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664
Query: 1737 RETGAIGQERVDNVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTR 1789
E A+ Q + +R + G ++ AE + E LLE R
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1724
Query: 1790 MQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLG 1849
+Q AA+ R L E + E L AS A + + E+ L
Sbjct: 1725 LQREAAAATQKRQ--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776
Query: 1850 VQVQQFQDVATRLQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVD 1901
+ +F+++A A E+A+ + +E +A +A + A G T+L
Sbjct: 1777 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836
Query: 1902 TA-----DKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRS 1956
A +K R L R++E Q E L + + ++E+E R
Sbjct: 1837 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQ 1895
Query: 1957 KNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
K L E L+++ Q EEI L+ + + E R+R E S+
Sbjct: 1896 KG------LVEDTLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSK 1948
Query: 2017 DASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLEL 2076
+ + EA A++ LA+ + ++ E++ K A E++ +R AALE+ L+
Sbjct: 1949 EQAELEA---ARQRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKA 2002
Query: 2077 K---ERQIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEP 2133
K R++ ER +E+ Q + A EA A E+ ++ + ++LQ E
Sbjct: 2003 KVEEARRLRERAEQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 2134 S 2134
S
Sbjct: 2060 S 2060
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1137 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1196
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1197 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1248
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1249 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1306
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1307 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1366
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1367 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1424
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1425 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1484
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1485 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1535
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1536 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1595
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1655
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1656 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1710
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1711 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1766
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2004
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 2005 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2064
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2065 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2124
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2125 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2185 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2234
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2235 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2290
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2291 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2331
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2332 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2385
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2386 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2423
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2474
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2475 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2535 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2592 RAALAHS 2598
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1258 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1316
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1317 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1376
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1377 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1425
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1426 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1481
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1482 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1521
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1522 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1564
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1565 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1606
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1607 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1658 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1702
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1703 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1757
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1758 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1817
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1818 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1875
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1876 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1935
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1936 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1995
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 1996 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2043
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2094
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2154
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2214
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2274
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2275 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2328
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2329 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2386
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2387 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2432
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2433 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2487
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2547
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2548 AEEGVRRKQEELQQLEQQRRQQEEL 2572
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1658 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1717
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1774
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1775 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1834
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1835 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1889
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1890 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1941
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1942 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1998
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 1999 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2052
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2053 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2109
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2168
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2169 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2219
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2220 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2277 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2446
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2447 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2556
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2557 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2602
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1931 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1986
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 1987 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2042
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2043 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2097
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2152
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2153 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2194
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2195 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2310
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2311 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2423
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2479
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2539
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2540 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2597
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2598 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2657
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2658 LAQGHTTVDEL 2668
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1018 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1077
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1078 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1137
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1138 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1197
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1198 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1257
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1258 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1314
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1315 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1361
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1416
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1417 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1464
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1465 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1519
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1520 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1572
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1573 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1629
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1689
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1690 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1745
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1800
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1801 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1853
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1854 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1911
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1912 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2031
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2091
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2092 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2145
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2146 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2190
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2191 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2228
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2285
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2286 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2345
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2346 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2405
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2406 TELATQEKVT 2415
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 372 bits (956), Expect = e-102
Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)
Query: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
A E + ++Y L LL W+ R+F +S ++ F ++
Sbjct: 274 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
+E P K +K + + +++ ++A KV G D+ + W L A RE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
D + +R L + Q L K+ H Q + + R + LRL
Sbjct: 441 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 499
Query: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Q LQS ++R E + + QD+L W++E + + AE+G L VE L
Sbjct: 500 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 556
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
H+ + I K++ + EG+ P +D + L+ + +L N +
Sbjct: 557 SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 608
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
KA+L + L F + W+ EKE+ D+ T++ + + A EL
Sbjct: 609 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+ ++++ ++ P +E+ + QW + L + +L++ +FQF
Sbjct: 668 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
D + + LQ L D AT L + +D E+L E +G + L +
Sbjct: 728 FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786
Query: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
+A+ + P H ++ L +A D +Q + + D C+L +
Sbjct: 787 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 831
Query: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
G + K L + G A S+ P ++E
Sbjct: 832 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 864
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
++ L + QA TL H VD + W + L
Sbjct: 865 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 900
Query: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
RD+ I +A R L E+ A +++ A R+SQ PE + + G
Sbjct: 901 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 960
Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
H ++L Q L+Q Q E S+ Q + +L D + L + + V +P
Sbjct: 961 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
E E Q + + + E++G R+ EKV+ + P L LE
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1068
Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
LG++ + RS + L + + + AE +L E L + + LEA
Sbjct: 1069 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127
Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
+A ++K E + + RD++ + G +L E ++ ++ +E+V + +R
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
+ + + + +E L R +L+ + ++ L W+ D + + +++ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
+ + QA + E+ H +E KQ ++ K LV+ K + E A+
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1298
Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
+K + S + S + L+TH +++I + + LR + + L R
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
+ + E + + K+ +L E AQ + E +++R + E + R + +++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1413
Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
K I +L ++L + A+ + + + ++ EI ++E
Sbjct: 1414 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
QRG + ++A ++ E + Q +RLR QR R A + A E
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1524
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
AEA +Q +E+ E A +R LRQ A + R ++ AQ L
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1578
Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
S E+ +L+ + + + + + EE +R+ + + + E + +LE+W
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
+ E VA + Q + R+ R E A+ Q + +R
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ G ++ AE + E LLE R+Q AA+ R
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1751
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
L E + E L AS A + + E+ L + +F+++A A
Sbjct: 1752 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
E+A+ + +E +A +A + A G T+L A +K R L
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
R++E Q E L + + ++E+E R K L E L+++ Q
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 1923
Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
EEI L+ + + E R+R E S++ + EA A++ LA+ +
Sbjct: 1924 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 1979
Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
++ E++ K A E++ +R AALE+ L+ K R++ ER +E+ Q
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+ A EA A E+ ++ + ++LQ E S
Sbjct: 2037 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1262
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1263 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1320
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1380
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1381 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1499 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1549
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1724
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1725 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1780
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2018
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2199 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2248
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2304
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2345
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2346 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2399
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2400 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2437
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2488
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2549 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2606 RAALAHS 2612
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1330
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1439
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1440 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1535
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1536 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1578
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1579 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1620
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1621 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1672 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1717 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1889
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2057
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2289 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2342
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2400
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2401 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2446
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2447 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2501
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEEL 2586
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1788
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1849 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1903
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1955
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1956 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2012
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 2013 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2066
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2182
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2183 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2234 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2291 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2460
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2461 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2571 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2616
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2000
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2056
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2057 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2166
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2167 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2208
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2209 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2325 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2493
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2554 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2612 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2672 LAQGHTTVDEL 2682
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1091
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1092 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1211
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1271
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1328
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1329 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1430
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1431 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1478
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1479 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1533
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1534 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1643
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1759
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1814
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1815 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1867
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1868 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2106 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2159
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2160 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2205 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2242
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2299
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2420 TELATQEKVT 2429
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 372 bits (956), Expect = e-102
Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)
Query: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR
Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 100
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q
Sbjct: 101 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 159
Query: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+
Sbjct: 160 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 218
Query: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R
Sbjct: 219 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 277
Query: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
A E + ++Y L LL W+ R+F +S ++ F ++
Sbjct: 278 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 330
Query: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
+E P K +K + + +++ ++A KV G D+ + W L A RE
Sbjct: 331 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 387
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 388 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 444
Query: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
D + +R L + Q L K+ H Q + + R + LRL
Sbjct: 445 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 503
Query: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Q LQS ++R E + + QD+L W++E + + AE+G L VE L
Sbjct: 504 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 560
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
H+ + I K++ + EG+ P +D + L+ + +L N +
Sbjct: 561 SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 612
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
KA+L + L F + W+ EKE+ D+ T++ + + A EL
Sbjct: 613 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 671
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+ ++++ ++ P +E+ + QW + L + +L++ +FQF
Sbjct: 672 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 731
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
D + + LQ L D AT L + +D E+L E +G + L +
Sbjct: 732 FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 790
Query: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
+A+ + P H ++ L +A D +Q + + D C+L +
Sbjct: 791 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 835
Query: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
G + K L + G A S+ P ++E
Sbjct: 836 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 868
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
++ L + QA TL H VD + W + L
Sbjct: 869 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 904
Query: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
RD+ I +A R L E+ A +++ A R+SQ PE + + G
Sbjct: 905 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 964
Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
H ++L Q L+Q Q E S+ Q + +L D + L + + V +P
Sbjct: 965 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1017
Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
E E Q + + + E++G R+ EKV+ + P L LE
Sbjct: 1018 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1072
Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
LG++ + RS + L + + + AE +L E L + + LEA
Sbjct: 1073 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1131
Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
+A ++K E + + RD++ + G +L E ++ ++ +E+V + +R
Sbjct: 1132 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1191
Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
+ + + + +E L R +L+ + ++ L W+ D + + +++ +
Sbjct: 1192 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1248
Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
+ + QA + E+ H +E KQ ++ K LV+ K + E A+
Sbjct: 1249 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1302
Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
+K + S + S + L+TH +++I + + LR + + L R
Sbjct: 1303 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
+ + E + + K+ +L E AQ + E +++R + E + R + +++ +
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1417
Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
K I +L ++L + A+ + + + ++ EI ++E
Sbjct: 1418 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1469
Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
QRG + ++A ++ E + Q +RLR QR R A + A E
Sbjct: 1470 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1528
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
AEA +Q +E+ E A +R LRQ A + R ++ AQ L
Sbjct: 1529 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1582
Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
S E+ +L+ + + + + + EE +R+ + + + E + +LE+W
Sbjct: 1583 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1642
Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
+ E VA + Q + R+ R E A+ Q + +R
Sbjct: 1643 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ G ++ AE + E LLE R+Q AA+ R
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1755
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
L E + E L AS A + + E+ L + +F+++A A
Sbjct: 1756 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1814
Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
E+A+ + +E +A +A + A G T+L A +K R L
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874
Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
R++E Q E L + + ++E+E R K L E L+++ Q
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 1927
Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
EEI L+ + + E R+R E S++ + EA A++ LA+ +
Sbjct: 1928 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 1983
Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
++ E++ K A E++ +R AALE+ L+ K R++ ER +E+ Q
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+ A EA A E+ ++ + ++LQ E S
Sbjct: 2041 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1155 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1214
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1215 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1266
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1267 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1324
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1325 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1384
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1385 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1442
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1443 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1502
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1503 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1553
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1554 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1613
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1728
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1729 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1784
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2022
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 2023 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2082
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2083 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2142
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2143 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2203 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2252
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2253 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2308
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2309 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2349
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2350 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2403
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2404 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2441
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2492
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2493 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2553 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2610 RAALAHS 2616
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1334
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1335 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1394
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1395 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1443
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1444 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1499
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1500 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1539
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1540 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1582
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1583 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1624
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1625 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1676 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1720
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1721 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1775
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1776 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1893
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1894 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1953
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1954 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2013
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 2014 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2061
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2112
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2172
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2232
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2292
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2293 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2346
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2347 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2404
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2405 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2450
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2451 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2505
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2566 AEEGVRRKQEELQQLEQQRRQQEEL 2590
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1676 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1735
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1792
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1793 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1852
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1853 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1907
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1908 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1959
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1960 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2016
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 2017 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2070
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2071 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2127
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2186
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2187 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2237
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2238 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2295 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2464
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2465 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2574
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2575 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2620
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1949 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2004
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 2005 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2060
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2061 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2170
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2171 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2212
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2213 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2328
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2329 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2497
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2557
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2558 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2615
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2616 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2676 LAQGHTTVDEL 2686
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1036 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1095
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1096 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1155
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1156 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1215
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1216 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1275
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1276 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1332
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1333 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1379
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1434
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1435 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1482
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1483 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1537
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1538 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1590
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1591 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1647
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1707
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1708 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1763
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1818
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1819 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1871
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1872 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1929
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1930 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2049
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2109
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2110 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2163
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2164 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2208
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2209 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2246
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2303
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2304 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2363
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2364 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2423
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2424 TELATQEKVT 2433
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 372 bits (956), Expect = e-102
Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)
Query: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR
Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 96
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q
Sbjct: 97 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 155
Query: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+
Sbjct: 156 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 214
Query: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R
Sbjct: 215 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 273
Query: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
A E + ++Y L LL W+ R+F +S ++ F ++
Sbjct: 274 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 326
Query: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
+E P K +K + + +++ ++A KV G D+ + W L A RE
Sbjct: 327 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 383
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 384 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 440
Query: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
D + +R L + Q L K+ H Q + + R + LRL
Sbjct: 441 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 499
Query: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Q LQS ++R E + + QD+L W++E + + AE+G L VE L
Sbjct: 500 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 556
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
H+ + I K++ + EG+ P +D + L+ + +L N +
Sbjct: 557 SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 608
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
KA+L + L F + W+ EKE+ D+ T++ + + A EL
Sbjct: 609 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 667
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+ ++++ ++ P +E+ + QW + L + +L++ +FQF
Sbjct: 668 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 727
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
D + + LQ L D AT L + +D E+L E +G + L +
Sbjct: 728 FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 786
Query: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
+A+ + P H ++ L +A D +Q + + D C+L +
Sbjct: 787 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 831
Query: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
G + K L + G A S+ P ++E
Sbjct: 832 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 864
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
++ L + QA TL H VD + W + L
Sbjct: 865 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 900
Query: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
RD+ I +A R L E+ A +++ A R+SQ PE + + G
Sbjct: 901 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 960
Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
H ++L Q L+Q Q E S+ Q + +L D + L + + V +P
Sbjct: 961 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1013
Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
E E Q + + + E++G R+ EKV+ + P L LE
Sbjct: 1014 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1068
Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
LG++ + RS + L + + + AE +L E L + + LEA
Sbjct: 1069 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1127
Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
+A ++K E + + RD++ + G +L E ++ ++ +E+V + +R
Sbjct: 1128 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1187
Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
+ + + + +E L R +L+ + ++ L W+ D + + +++ +
Sbjct: 1188 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1244
Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
+ + QA + E+ H +E KQ ++ K LV+ K + E A+
Sbjct: 1245 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1298
Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
+K + S + S + L+TH +++I + + LR + + L R
Sbjct: 1299 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
+ + E + + K+ +L E AQ + E +++R + E + R + +++ +
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1413
Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
K I +L ++L + A+ + + + ++ EI ++E
Sbjct: 1414 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1465
Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
QRG + ++A ++ E + Q +RLR QR R A + A E
Sbjct: 1466 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1524
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
AEA +Q +E+ E A +R LRQ A + R ++ AQ L
Sbjct: 1525 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1578
Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
S E+ +L+ + + + + + EE +R+ + + + E + +LE+W
Sbjct: 1579 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1638
Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
+ E VA + Q + R+ R E A+ Q + +R
Sbjct: 1639 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ G ++ AE + E LLE R+Q AA+ R
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1751
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
L E + E L AS A + + E+ L + +F+++A A
Sbjct: 1752 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1810
Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
E+A+ + +E +A +A + A G T+L A +K R L
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870
Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
R++E Q E L + + ++E+E R K L E L+++ Q
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 1923
Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
EEI L+ + + E R+R E S++ + EA A++ LA+ +
Sbjct: 1924 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 1979
Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
++ E++ K A E++ +R AALE+ L+ K R++ ER +E+ Q
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+ A EA A E+ ++ + ++LQ E S
Sbjct: 2037 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1151 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1210
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1211 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1262
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1263 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1320
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1321 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1380
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1381 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1438
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1498
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1499 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1549
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1550 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1609
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1724
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1725 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1780
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2018
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 2019 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2078
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2079 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2138
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2139 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2199 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2248
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2249 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2304
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2305 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2345
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2346 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2399
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2400 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2437
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2488
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2549 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2606 RAALAHS 2612
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1330
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1331 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1390
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1391 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1439
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1440 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1495
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1496 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1535
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1536 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1578
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1579 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1620
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1621 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1672 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1717 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1771
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1772 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1889
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 1890 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1949
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 1950 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2009
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 2010 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2057
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2168
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2289 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2342
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2343 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2400
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2401 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2446
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2447 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2501
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2562 AEEGVRRKQEELQQLEQQRRQQEEL 2586
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1672 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1731
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1788
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1789 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1849 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1903
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 1904 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1955
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 1956 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2012
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 2013 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2066
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2067 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2123
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2182
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2183 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2233
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2234 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2291 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2460
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2461 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2570
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2571 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2616
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 1945 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2000
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 2001 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2056
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2057 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2166
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2167 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2208
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2209 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2324
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2325 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2493
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2553
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2554 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2611
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2612 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2672 LAQGHTTVDEL 2682
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1032 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1091
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1092 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1151
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1152 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1211
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1212 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1271
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1272 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1328
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1329 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1375
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1430
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1431 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1478
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1479 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1533
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1534 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1586
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1587 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1643
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1703
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1704 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1759
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1814
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1815 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1867
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 1868 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1925
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 1926 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2106 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2159
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2160 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2204
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2205 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2242
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2299
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2300 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2359
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2360 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2420 TELATQEKVT 2429
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 372 bits (956), Expect = e-102
Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%)
Query: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR
Sbjct: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q
Sbjct: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292
Query: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+
Sbjct: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351
Query: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R
Sbjct: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410
Query: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
A E + ++Y L LL W+ R+F +S ++ F ++
Sbjct: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463
Query: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
+E P K +K + + +++ ++A KV G D+ + W L A RE
Sbjct: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
LR+E R E L+++ + +A + E L++ L+ D L A ++ +E
Sbjct: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577
Query: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
D + +R L + Q L K+ H Q + + R + LRL
Sbjct: 578 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 636
Query: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Q LQS ++R E + + QD+L W++E + + AE+G L VE L
Sbjct: 637 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 693
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
H+ + I K++ + EG+ P +D + L+ + +L N +
Sbjct: 694 SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 745
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
KA+L + L F + W+ EKE+ D+ T++ + + A EL
Sbjct: 746 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+ ++++ ++ P +E+ + QW + L + +L++ +FQF
Sbjct: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
D + + LQ L D AT L + +D E+L E +G + L +
Sbjct: 865 FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923
Query: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
+A+ + P H ++ L +A D +Q + + D C+L +
Sbjct: 924 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 968
Query: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
G + K L + G A S+ P ++E
Sbjct: 969 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 1001
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
++ L + QA TL H VD + W + L
Sbjct: 1002 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1037
Query: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
RD+ I +A R L E+ A +++ A R+SQ PE + + G
Sbjct: 1038 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1097
Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
H ++L Q L+Q Q E S+ Q + +L D + L + + V +P
Sbjct: 1098 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150
Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
E E Q + + + E++G R+ EKV+ + P L LE
Sbjct: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1205
Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
LG++ + RS + L + + + AE +L E L + + LEA
Sbjct: 1206 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264
Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
+A ++K E + + RD++ + G +L E ++ ++ +E+V + +R
Sbjct: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324
Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308
+ + + + +E L R +L+ + ++ L W+ D + + +++ +
Sbjct: 1325 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381
Query: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367
+ + QA + E+ H +E KQ ++ K LV+ K + E A+
Sbjct: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1435
Query: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
+K + S + S + L+TH +++I + + LR + + L R
Sbjct: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495
Query: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478
+ + E + + K+ +L E AQ + E +++R + E + R + +++ +
Sbjct: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1550
Query: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537
K I +L ++L + A+ + + + ++ EI ++E
Sbjct: 1551 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602
Query: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595
QRG + ++A ++ E + Q +RLR QR R A + A E
Sbjct: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1661
Query: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650
AEA +Q +E+ E A +R LRQ A + R ++ AQ L
Sbjct: 1662 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1715
Query: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705
S E+ +L+ + + + + + EE +R+ + + + E + +LE+W
Sbjct: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775
Query: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756
+ E VA + Q + R+ R E A+ Q + +R
Sbjct: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ G ++ AE + E LLE R+Q AA+ R
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1888
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868
L E + E L AS A + + E+ L + +F+++A A
Sbjct: 1889 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947
Query: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916
E+A+ + +E +A +A + A G T+L A +K R L
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007
Query: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976
R++E Q E L + + ++E+E R K L E L+++ Q
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 2060
Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
EEI L+ + + E R+R E S++ + EA A++ LA+ +
Sbjct: 2061 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 2116
Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093
++ E++ K A E++ +R AALE+ L+ K R++ ER +E+ Q
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134
+ A EA A E+ ++ + ++LQ E S
Sbjct: 2174 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Score = 101 bits (251), Expect = 9e-21
Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)
Query: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641
D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R +
Sbjct: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347
Query: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700
++ E D +W+++ + + S +A ++LR A LE+I +
Sbjct: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1399
Query: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756
+ ++F I A IK+ Q QL+ +A+ KK + + Q + DL+
Sbjct: 1400 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1457
Query: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806
+ L S E + + E R ++ + E L E +E Q A
Sbjct: 1458 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1517
Query: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860
Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A
Sbjct: 1518 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575
Query: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920
+ E+ + E E+ LE + + + E++ L + + E
Sbjct: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635
Query: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
R+V QD + QA L S + ++A EE + + E+
Sbjct: 1636 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1686
Query: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038
+ L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++
Sbjct: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746
Query: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
E Q ++ + +E+ E+ QL+A QA QK++A + + EA
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806
Query: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156
E+ ++ +++ ++ ++ E ++ +G T + L Q L L A
Sbjct: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1861
Query: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215
E + L + L Q++A A E LA + + L A++A R E+
Sbjct: 1862 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1917
Query: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268
+ E ++ ++ + +L E +++ K + QL E+ + +A+ E
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319
+ + L+ + + N++L + + R L + +H+A +
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369
+EL +G +E+ + +Q+ +E K F + K E L R+ + T +
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097
Query: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421
K Q L AAR L R + + K ++A E+ R L V R+ AK+
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2155
Query: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463
+ +Q + R+ +L + AQ EE A L E+ LD
Sbjct: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215
Query: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506
L E R+ E+ A++Q R+ VEE L QSA+
Sbjct: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275
Query: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558
Q Q +++ Q E+ H E L++ Q+ + LEE
Sbjct: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
Query: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615
D + LQRL+ +A EA Q+ ++ + + +EL + I +
Sbjct: 2336 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2385
Query: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675
E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A
Sbjct: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2441
Query: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734
+ +AE+ K K++ + +LK E + L+Q +KEL +++ R
Sbjct: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2482
Query: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794
+ + Q+ + F +R ++A ++ + L A++ +R Q A
Sbjct: 2483 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2536
Query: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851
D R+ R+ E++G E HR A + ++ L L +Q
Sbjct: 2537 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2574
Query: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
QQ A RL+ A A ++A+ +Q K +E+ Q L L +T
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2625
Query: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959
+ F +D L E I Q + Q +V+ + L + Q ++E +
Sbjct: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685
Query: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016
A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ +
Sbjct: 2686 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742
Query: 2017 DASVAEA 2023
A++A +
Sbjct: 2743 RAALAHS 2749
Score = 78.2 bits (191), Expect = 8e-14
Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)
Query: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382
++++ N++ + QL + + K PK Q G+ V+ + R + T
Sbjct: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1467
Query: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438
K +S+ R E E ++ R L E K QLA + A E
Sbjct: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527
Query: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498
E Q+ + ++ + AAV+A ++K E L+ L Q E E ++
Sbjct: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1576
Query: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557
A + + LR ++E ++ R +LE T + + L ++ +E +A A+
Sbjct: 1577 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632
Query: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615
L +V+D Q+ + E ++A +VKA + + +++ L
Sbjct: 1633 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1672
Query: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675
Q EEL A + +L Q++ ++ Q+ +L+ + ++ L
Sbjct: 1673 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1715
Query: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735
Q K +F ++ A LE+ QE H VA+ + + E R ++ A
Sbjct: 1716 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1757
Query: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791
++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E
Sbjct: 1758 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851
RG E+QA V R A +EL +Q QQRL +L
Sbjct: 1809 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853
Query: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911
+ ET+ GE+++ L E E+ + + L+ E+ + +++ + +
Sbjct: 1854 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908
Query: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966
E S + KQ + R++ + R + A R + E
Sbjct: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968
Query: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009
+ + +K + E+ + R LA A QR+ LE A +A
Sbjct: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 2026
Query: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061
++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+
Sbjct: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086
Query: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108
++++ +D QA L + Q+ +A+E+ + +SL E+ +Q +
Sbjct: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146
Query: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165
E++ + +R++E E+ Q +RL+ E ++H A
Sbjct: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2194
Query: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225
QE Q+ +Q +++L EAA + E+ E +
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277
V+ +L A+ + EK++ ++ +A++A++ + + +
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305
Query: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331
F + + +L T Q D +NL ++ L+ +A E A +E
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365
Query: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390
+ M+E + A + + AL R D Q +E+ + + RL A
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425
Query: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448
+A QL +D + +ML K++ V++ ++ E EL Q + E+
Sbjct: 2426 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2479
Query: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507
E+ L E ++ LE+ R + L++S + E L V E A+
Sbjct: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2537
Query: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567
+ Q F K+ + + ++ R E Q LV+ EI Q + +
Sbjct: 2538 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2583
Query: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625
RLREA A L+R ++ EA+ L ++E + EQ L E ++ +
Sbjct: 2584 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2638
Query: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677
L+++R +E ++QL ++AQ L + +Q+ RL +++ +
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698
Query: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702
E +RK E + L Q +R+ ++L
Sbjct: 2699 AEEGVRRKQEELQQLEQQRRQQEEL 2723
Score = 77.8 bits (190), Expect = 1e-13
Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)
Query: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329
E +R GK + A+ E EK + G A L ++ I + +
Sbjct: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868
Query: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387
L +Q++ A + R + + + +EVLL S+ RA + T K
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1925
Query: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444
L ++ R E EEA R LA + RQ E AR+ +R A + + E RL
Sbjct: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
+ L EA ++ + D A R LE+ A + + + ++ D
Sbjct: 1986 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 2040
Query: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563
+ L R +++ L+ RRQ E LAL+ F+ KA L E G+
Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 2092
Query: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623
ED L+ + E + A Q ++ A + E + + + ++ + EE+
Sbjct: 2093 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2149
Query: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683
+ KA++E+++RL + E + A +E L ++ +Q+K + +
Sbjct: 2150 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2203
Query: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740
L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + +
Sbjct: 2204 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260
Query: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798
A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ +
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2319
Query: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857
+EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V
Sbjct: 2320 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2370
Query: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914
+ M E K A +E + L D + Q ++MK + + +++AA
Sbjct: 2371 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974
R R++ + + L + + ++ E+ +AV A R+ ++ + ++
Sbjct: 2428 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480
Query: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032
+ ++ K+ + + LA QR L + + A + L+ ++ + +ED
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540
Query: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091
+ +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2597
Query: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L + +LLQ +K E Q ++E+ + +Q E L QR ++
Sbjct: 2598 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211
L ++++ Q Q+ Q+ + E Q + E AE G+R+ +
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2707
Query: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267
+ L +E R + +L+AE N +++E++QL+E++HR ++E +
Sbjct: 2708 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2753
Score = 75.1 bits (183), Expect = 7e-13
Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)
Query: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460
E E R + + +R ++ +L R+ A E E +R A++ LAA E A
Sbjct: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2137
Query: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512
++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++
Sbjct: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2193
Query: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572
+Q + Q L+ TL ++ D L + + AE + E E + ++
Sbjct: 2194 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2248
Query: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632
EA+ Q + +A A + K + + + R + EQ A A+
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2303
Query: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692
+E+ K+ AE +++K Q+ L + L LQ + + L LD
Sbjct: 2304 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2345
Query: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747
L+++ EA ++ Q+E + V Q ++L L A + L+D +N +
Sbjct: 2346 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794
F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461
Query: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852
+ E L+QQ + E+ R RLQ +E Q +A+ QR EA
Sbjct: 2462 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514
Query: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907
+ E + +L + E + A E E++ HR ++ QE TL+ ++
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574
Query: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967
++ E E+++ ++ L + Q E + L +
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2630
Query: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026
++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690
Query: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079
E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+
Sbjct: 2691 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748
Query: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126
+++ AS+ ++LP L A + DG + S QR++E+G ++
Sbjct: 2749 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808
Query: 1127 VIQGQTDPEYL 1137
+ QG T + L
Sbjct: 2809 LAQGHTTVDEL 2819
Score = 74.3 bits (181), Expect = 1e-12
Identities = 300/1510 (19%), Positives = 574/1510 (38%), Gaps = 201/1510 (13%)
Query: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+
Sbjct: 1169 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1228
Query: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793
+ QG + L+A + + + AT+A KK + E +
Sbjct: 1229 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1288
Query: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853
E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++
Sbjct: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1348
Query: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884
+ E+ D W+ + +++ + M + D+ LE++E
Sbjct: 1349 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1408
Query: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941
Q+ I D E++ T Q++ V + A V+SG S V Q L T + T
Sbjct: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1465
Query: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000
L S+ Y ET + + ++ ++ E + R+ LA + A K L
Sbjct: 1466 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512
Query: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056
A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS +
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1567
Query: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116
+++QA + QA + + E++ + E +Q G + E+ Q
Sbjct: 1568 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1615
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176
R +E+ + Q Q + E L R + D E S A+ +E Q+
Sbjct: 1616 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1670
Query: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236
A+ + +E L E L AE + + ++E + + + S A
Sbjct: 1671 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1723
Query: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294
E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L
Sbjct: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1780
Query: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349
L Q + ++L + Q AE A G E ++L ++++ Q
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409
+Q+ A + L+A T++ Q RLQ A + + Q + K
Sbjct: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1896
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469
+ +LA R E++ E+ + E G +L+ E L L +
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1951
Query: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529
R++QL A Q + E E + E+ + ++ T L+T K + +NE L
Sbjct: 1952 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 2004
Query: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586
ED + ++L E A D+EERL L+ + D E G ++ R R E
Sbjct: 2005 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062
Query: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642
+ L A +A G+ EL + I + E + ++ RQ++ + R ++
Sbjct: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122
Query: 1643 LASRAQGLLSAGHPEG-------EQIIRLQGQVDK-------------HYAGLKDVAEER 1682
R Q L+A E++ RL+ +V++ L A ++
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182
Query: 1683 KRKLENMYHLFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRDKFRDFARETGA 1741
+ + E H F ++++ +L+Q + +++ V + ++ R A A
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2242
Query: 1742 IGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHR 1801
+ +V+ ERL + +A A+ + ++ + + R Q A+ L +
Sbjct: 2243 QSRRQVEEA----ERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAA--LRQ 2296
Query: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861
AE+ EKH++ AE R E+EL L +Q+++
Sbjct: 2297 KQAADAEM-----EKHKKF----------AEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L KAEA + A +R+Q+ + FS+ R + +
Sbjct: 2342 LDEELQRLKAEATE----------------AARQRSQVEE-----ELFSV-RVQMEELSK 2379
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ +IE + R + + ++ Q AE + +A L + R Q +EE
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE-- 2436
Query: 1982 EKLQQVMSRRKEMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGH 2039
+ QQ K + EK +A E RL+ E+ Q ++ + +A + ++ +
Sbjct: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2496
Query: 2040 TVDSVEKLIKRHEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEE 2095
++ ++ + ++ AER A + + ++ Q + AEE G +
Sbjct: 2497 ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2556
Query: 2096 GETAGEAPVS 2105
E A + V+
Sbjct: 2557 TELATQEKVT 2566
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
Length = 1369
Score = 337 bits (865), Expect = 6e-92
Identities = 348/1301 (26%), Positives = 564/1301 (43%), Gaps = 171/1301 (13%)
Query: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109
DER+ VQKKT TKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR
Sbjct: 171 DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 229
Query: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169
H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q
Sbjct: 230 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 288
Query: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229
E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+
Sbjct: 289 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 347
Query: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289
NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R
Sbjct: 348 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 406
Query: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349
A E + ++Y L LL W+ R+F +S ++ F ++
Sbjct: 407 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 459
Query: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409
+E P K +K + + +++ ++A KV G D+ + W L A RE
Sbjct: 460 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 516
Query: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469
LR+E R E L+++ + +A + E L + L+ D L A ++ +E
Sbjct: 517 LRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSD---IRLLAAGKVPQRAGEVER 573
Query: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509
D + +R L + Q L K+ H Q + + R + LRL
Sbjct: 574 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632
Query: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
Q LQS ++R E + + QD+L W++E + + AE+G L VE L
Sbjct: 633 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 689
Query: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628
H+ + I K++ + EG+ P +D + L+ + +L N +
Sbjct: 690 SHRGLHQSIEEFQAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 741
Query: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688
KA+L + L F + W+ EKE+ D+ T++ + + A EL
Sbjct: 742 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 800
Query: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748
+ ++++ ++ P +E+ + QW + L + +L++ +FQF
Sbjct: 801 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 860
Query: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804
D + + LQ L ++ D AT L + +D E+L E +G + L +
Sbjct: 861 FSDVREAEGQLQKLQEALRRKN-SCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 919
Query: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864
+A+ + P H ++ L +A D +Q + + D C+L +
Sbjct: 920 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 964
Query: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924
G + K L + G A S+ P ++E
Sbjct: 965 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 997
Query: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984
V++ L + QA TL H VD + W + L
Sbjct: 998 VQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1033
Query: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034
RD+ I +A R L E+ A +++ A R+SQ PE + + G
Sbjct: 1034 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1093
Query: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090
H ++L Q L+Q Q E S+ Q + +L D + L + + V +P
Sbjct: 1094 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1146
Query: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149
E E Q + + + E++G R+ EKV+ + P L LE
Sbjct: 1147 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1201
Query: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202
LG++ + RS + L + + + AE +L E L + + LEA
Sbjct: 1202 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260
Query: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255
+A ++K E + + RD++ + G +L E ++ ++ +E+V + +R
Sbjct: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320
Query: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWIND 1292
+ + + + +E L R +L+ + ++ L W+ D
Sbjct: 1321 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQD 1358
Score = 64.3 bits (155), Expect = 1e-09
Identities = 88/440 (20%), Positives = 175/440 (39%), Gaps = 42/440 (9%)
Query: 1562 LQSSWDRLREAAAGRLQRLR---DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEE- 1617
++ W +L A R ++LR + E Q + + EA + E++L+ + D
Sbjct: 499 VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL 558
Query: 1618 -GAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLK 1676
A + +R +R ++ I+ L + Q L HP+GEQ+ R ++ + ++
Sbjct: 559 LAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR 618
Query: 1677 DVAEERKRK-------------LENMYHLFQLKRET----DDLEQWISEKELVASSPEMG 1719
R + L+++ +L+ T DL W+ E + E G
Sbjct: 619 TEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWG 678
Query: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERL-IDAGHSEAATIAEWKDGLNEM 1778
D V R + ++ A IER D G AT ++D L +
Sbjct: 679 VDLPSVEAQLGSHRGL--------HQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRL 730
Query: 1779 WADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDAS----TAESF 1834
+L+++ L + LH + + L ++EK E+VG D S +
Sbjct: 731 DLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE---EEVGFDWSDRNTNMTAK 787
Query: 1835 HRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAG 1894
++A REL L ++++ Q+ RL + +++ + + W +L C
Sbjct: 788 KESYSALMRELELKEKKIKELQNAGDRLLREDHPAR-PTVESFQAALQTQWSWMLQLCCC 846
Query: 1895 RRTQLVDTADKFRFFSMARDL---LSWMESIIRQIETQERPRDVSSVELLMKYHQGINAE 1951
L + A F+FFS R+ L ++ +R+ + +R V+ +E L++ Q +
Sbjct: 847 IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQ 906
Query: 1952 IETRSKNFSACLELGESLLQ 1971
+ + S + ++++Q
Sbjct: 907 LNEYKGHLSGLAKRAKAVVQ 926
Score = 49.3 bits (116), Expect = 4e-05
Identities = 196/982 (19%), Positives = 359/982 (36%), Gaps = 180/982 (18%)
Query: 701 HGMVARKQFG--HPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAW 758
H + K++G H I R K++ +++++L+ L K +A + AD L
Sbjct: 495 HPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADAL--- 551
Query: 759 LQDAHRLLSGEDVGQDEGAT-RALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSP 817
LQ RLL+ V Q G R L K + + + + Q + + +R
Sbjct: 552 LQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGE---QMYRRVY 608
Query: 818 DVTHRLQALRELYQ-----------QVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
+ RL A+R Y VAQ L+ + + L+ T+ D W+ E
Sbjct: 609 RLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-WVEE 667
Query: 867 KEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVK 926
+ + E L +E L Q ++ +I+ L P +R
Sbjct: 668 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQL----SPATRGA- 722
Query: 927 QYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD 986
Y+D L + L++ + + S +H++ + W+ +K + E D
Sbjct: 723 -YRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDR 780
Query: 987 LAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGL 1046
+ A + S L R++ + ++ L+ +L+ + + Q L+ W +
Sbjct: 781 NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840
Query: 1047 QQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASE---DMPESLPEAEQLLQQH 1103
Q E L E + F D+ + + L Q+A+ + D ++ E LLQ
Sbjct: 841 LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900
Query: 1104 AGIKDEIDGHQDSYQRVKESGEKVIQGQT-DPEYLLLGQRLEGLDTGWNALGRMWESRSH 1162
K++++ ++ + + + V+Q + P + + G R
Sbjct: 901 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRG-------------------RLP 941
Query: 1163 TLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRD 1222
LA C D KQ E + + +G + +
Sbjct: 942 LLAVC--------DYKQVEVTVHKGDEC---------------------QLVGPAQPSHW 972
Query: 1223 KVLSPVDSGNKLVAEGNLY-----SDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ 1277
KVLS SG++ + + +++E V +E +H+ + V ++ L Q
Sbjct: 973 KVLS--SSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQ 1030
Query: 1278 NFLQNCQELTLWINDKLLTSQDVSYDEARN-LHNKWLKHQAFVAELASHEGWLENIDAEG 1336
+ ++ Q + W L T + + +E R LH+ L +QAF+ + G+
Sbjct: 1031 SLRRDVQLIRSW---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGF-----GPE 1082
Query: 1337 KQLMDEKPQFTAL--VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKW 1394
+LM E+ + Q L++L Q +E + D+RLQ A +
Sbjct: 1083 DRLMAEREYGSCSHHYQQLLQSLE------QGAQEESRCQRCISELKDIRLQLEACETRT 1136
Query: 1395 ISAMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL 1454
+ + L +P ++ +R+ +Q + A+V +G+ G A L
Sbjct: 1137 VHRLRLPL-DKEPARECA---------QRIAEQQKAQ--------AEVEGLGK--GVARL 1176
Query: 1455 SIE-KRFLDLLEPLGRR---KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL 1510
S E ++ L L EP + +LE + KL+ R L SA Y L
Sbjct: 1177 SAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSL---------------SAIYLEKL 1221
Query: 1511 QTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLR 1570
+T+ L ++ Q + + H +QL EA Q + L L
Sbjct: 1222 KTISLVIRGTQGAEEVLRAHE----------EQLKEA-----QAVPATLPEL-------- 1258
Query: 1571 EAAAGRLQRLRDANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
EA L++LR EAQQ DA + DE+ +E + +RH +
Sbjct: 1259 EATKASLKKLRAQAEAQQPTFDA--------------LRDELRGAQEVGERLQQRHGERD 1304
Query: 1631 RAVEDYGRNIKQLASRAQGLLS 1652
VE + + QL R Q +L+
Sbjct: 1305 VEVERWRERVAQLLERWQAVLA 1326
Score = 45.4 bits (106), Expect = 6e-04
Identities = 72/370 (19%), Positives = 144/370 (38%), Gaps = 28/370 (7%)
Query: 1352 QKLEALHRLWDELQATT---KEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPG 1408
++LE L R+ +LQ +E+ A SD+RL ++A + R+ +
Sbjct: 522 ERLECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRL---------LAAGKVPQRAGEVE 572
Query: 1409 KDLTSVNRMLAKL-KRVEDQVNVRKEELGELFAQVPSMGEE----GGDADLSIEKRFLDL 1463
+DL + M+ L V+ + R + +++ +V + E + +L ++
Sbjct: 573 RDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 632
Query: 1464 LEPLGRRKKQLESSRAKLQIS--RDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQ 1521
+ + Q R +L+ S R L+D WVEE A++G +L +V+ + ++
Sbjct: 633 ATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 692
Query: 1522 TLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLR 1581
L I ++E QL A +D LG L + +L ++ RL+ L
Sbjct: 693 GLHQSIEEFQAKIERARSDEGQLSPATRGAYRDC---LGRLDLQYAKLLNSSKARLRSLE 749
Query: 1582 DANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIK 1641
+ + A + W+ E+E + + + + R +E + IK
Sbjct: 750 SLH---SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIK 806
Query: 1642 QLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVA---EERKRKLENMYHLFQLKRE 1698
+L + LL HP + Q + ++ + + E ++ + F RE
Sbjct: 807 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 866
Query: 1699 TDDLEQWISE 1708
+ Q + E
Sbjct: 867 AEGQLQKLQE 876
Score = 35.0 bits (79), Expect = 0.79
Identities = 46/190 (24%), Positives = 78/190 (41%), Gaps = 29/190 (15%)
Query: 1895 RRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIET 1954
RR +L D+ ++ +DLL+W+E +++ E D+ SVE + H+G++ IE
Sbjct: 646 RRPELEDSTLRY-----LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE- 699
Query: 1955 RSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEK-WEARWERLRMLLEVCQ 2013
F A +E S + Q S R + + R K + RLR L +
Sbjct: 700 ---EFQAKIERARS---DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 753
Query: 2014 FSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTT 2073
F A+ WL +E D+ +++T A++ +
Sbjct: 754 FVAAATKELMWLNEKEEEEVGFDWS----------------DRNTNMTAKKESYSALMRE 797
Query: 2074 LELKERQIAE 2083
LELKE++I E
Sbjct: 798 LELKEKKIKE 807
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 298 bits (764), Expect = 3e-80
Identities = 244/786 (31%), Positives = 375/786 (47%), Gaps = 73/786 (9%)
Query: 23 WDAPDDELDNDNSSARLFERSR--IKALADEREVVQKKTFTKWVNSHLARVSCRITDLYK 80
W+ P E S + + + + +ADER+ VQKKTFTKWVN HL +V I DLY+
Sbjct: 45 WNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYE 104
Query: 81 DLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVD 140
DLRDG LI LLEVLSG LP+ KG+MR H L+NV AL FLK+++V L N+ + DI D
Sbjct: 105 DLRDGHNLISLLEVLSGIKLPRE-KGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITD 163
Query: 141 GNHRLVLGLIWTIILRFQIQDIVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTS 200
GN +L LGLIWTIIL FQI DI + + G SAK+ LLLW Q TAGY + TNF+S
Sbjct: 164 GNPKLTLGLIWTIILHFQISDIYISGESG--DMSAKEKLLLWTQKVTAGYTGIKCTNFSS 221
Query: 201 SWKDGLAFNALIHKHRPDLIDFDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTEN 260
W DG FNALIH++RPDL+D ++++ + R NLE AF VAER LG+ LLD EDV +
Sbjct: 222 CWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPS 280
Query: 261 PDEKSIITYVVAFYHYFSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQ 320
PDEKS+ITYV + Y F K+ EG G+ I A E + ++Y L+ WI+Q
Sbjct: 281 PDEKSVITYVSSIYDAFPKVP----EG---GEGIS-ATEVDSRWQEYQSRVDSLIPWIKQ 332
Query: 321 TITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKV 380
+++ + F + ++ + ++ E K +EKG +E L ++ + K+
Sbjct: 333 HTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKL 392
Query: 381 YTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE 440
G +D+ W L RE +LR + R E L Q+A + A E L+
Sbjct: 393 ---PQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLT- 448
Query: 441 NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAY----EERVRALEDLAQELEKENYHDQ 496
+A++ D A +E+ + E+D Y E +R L+ Q L ENY+
Sbjct: 449 ----LAKNTLQADAAHLESGQPVQ--CESDVIMYIQECEGLIRQLQVDLQILRDENYYQL 502
Query: 497 KRITAR----KDNILRLWSYLQELLQSRR---------QRLETTLALQKLFQDMLH--SI 541
+ + R +D ++ L L + L TT + H S
Sbjct: 503 EELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSST 562
Query: 542 DWMDE--IKAHLL---SAEFGKHLLEVEDLLQ--KHKLMEADIAIQGDKVKAI------- 587
W + +A L+ S+E +L V +LL + M+ + A G+ + ++
Sbjct: 563 SWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQ 622
Query: 588 ------------TAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ 635
+ + EGK Q + + LE + +L ++ R L+
Sbjct: 623 QHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAE-TLGKLETQYCKLKETSSFRMRHLQS 681
Query: 636 SKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQ 695
L KF W+ EKE+ + D+ + +++ + EL
Sbjct: 682 ---LHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRS 738
Query: 696 IFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDL 755
+ A + +EA V +Q +K L ++++++ +FQF DA +L
Sbjct: 739 LQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDAREL 798
Query: 756 KAWLQD 761
+++L++
Sbjct: 799 ESFLRN 804
Score = 159 bits (401), Expect = 4e-38
Identities = 324/1660 (19%), Positives = 683/1660 (41%), Gaps = 133/1660 (8%)
Query: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQ---LARRFDRKAAMRETWLSENQRLV 445
++D + LE E R L RQ++LE LA++F A +LS ++ +
Sbjct: 3350 LADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKL 3409
Query: 446 AQDN-FGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK- 503
A G A ++ +H+A+E D + V + Q L ++ + + K
Sbjct: 3410 ANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKI 3469
Query: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEI------------KAH 550
D++ +S +Q+ + L+ L+ +LF +D + ++W+ E+ K
Sbjct: 3470 DSLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD 3529
Query: 551 LLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQD 610
+L + HL E+++ + K D AI+ + A LK T G+ + +IQ+
Sbjct: 3530 VLHRQHADHLALNEEIVNRKK--NVDQAIKNGQ------ALLKQTTGE-----EVLLIQE 3576
Query: 611 RISHLEQCFEELSNMAAGRKAQLEQSKRL-WKFFWEMDEAESWIKE-KEQIYSSLDYGKD 668
++ ++ + +++ ++ LEQ+++L KF +E W++E +E++ +S
Sbjct: 3577 KLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPT 3636
Query: 669 LTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQ 727
+ Q++ K + E+ L+ + + + ++ + ++ + + + Q+
Sbjct: 3637 GEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKL 3696
Query: 728 LKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKH 785
+ D + A + Q++ AD AW+ + R L++ + ++ T A +
Sbjct: 3697 VSDTIGQRVDEIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQ 3756
Query: 786 KDFLEELEESRGVMEHL-EQQAQGFPEEFRDSPDVTH-RLQALRELYQQVVAQADLRQQR 843
K F ++ + M+ L +++ F + V + ++L + Y+ + R R
Sbjct: 3757 KAFSIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYAR 3816
Query: 844 LQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMT 902
L+ A L F ET + W+ E +A++ P D E ++ + +EM+ L
Sbjct: 3817 LERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI--DHEQLRQQ----QEEMRQLRE 3870
Query: 903 QIDGVNLAANSLVESGHPRSREVKQYQDHL-NTRWQAFQTLVSERREAV-DSALRVHNYC 960
I + L++ G P+ +E+ + + ++Q + + ++ +E V AL +
Sbjct: 3871 SIAEHKPHIDKLLKIG-PQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAV 3929
Query: 961 VDCEETSKWITDKTKVVESTKDLGRDL-------AGIIAIQRKLSGLER---DVAAIQAR 1010
+ +++ ++E+ ++L L A + I+ +S + ++ +Q
Sbjct: 3930 SQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPS 3989
Query: 1011 VDALERESQQLMDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-Q 1064
+AL+R ++L+ +D+ + Q L+++ W+ ++ + +E +V +L +
Sbjct: 3990 FEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAE 4049
Query: 1065 AFLQDLDDFQAWLSITQKAVASEDMPESLPEA-EQLLQQHAGIKDEIDGHQDSYQRVKES 1123
F D+ + TQ V + P P +Q ++ IK+E DG + + ++
Sbjct: 4050 KFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRIL 4109
Query: 1124 GEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI 1183
G +I + E + + ++ ++ W L + W+ R L + +D QA
Sbjct: 4110 GADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFD 4169
Query: 1184 -LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYS 1242
L N L + P + + +D L M+ + +V KL +G L
Sbjct: 4170 WLDNTVIKLCTMPPVGT------DLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELML 4223
Query: 1243 DKIKEKVQ-------LIEDRHRKNN--EK-AQEASVLLRDNLELQNFLQNCQELTLWIN- 1291
K ++ L E +H N EK A L L L F +EL W+
Sbjct: 4224 KKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTH 4283
Query: 1292 -DKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTAL- 1349
++LL +Q + + + + KH ++ +H+ +E ++ G +L++ A
Sbjct: 4284 TEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASS 4343
Query: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA-DLNKWISAMEDQLRSDDPG 1408
+ +LEA+++ W+ + T+E+ Q L + + D ++ ME QL + P
Sbjct: 4344 LRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPT 4403
Query: 1409 KDLTSVNR--------MLAKLKRVEDQVN--VRKEELGELFAQVPSMGEEGGDADLSIEK 1458
L R + ++LK E+ N + K L L G + + +E+
Sbjct: 4404 GGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQ 4463
Query: 1459 RFLDLLEPLGRRKKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQ 1514
++ + + RK +LE + + L++ W+ E+ L +A N TV
Sbjct: 4464 KWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILN--TVL 4521
Query: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEI-DCQDLEERLGHLQSSWDRLREAA 1573
+++++ NE+ H ++ ++ Q G QL ++ D ++ L +QS W+++ + +
Sbjct: 4522 SQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRS 4581
Query: 1574 AGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQR 1631
R + L DA + A+Q++ + W+ + E ++ S+ EI D + + L +H Q+
Sbjct: 4582 IERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQK 4641
Query: 1632 AVED----YGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
+ Y I+ RA + + +++ G+V + + + ER+ KLE
Sbjct: 4642 TLGGKQPVYDTTIR--TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLE 4699
Query: 1688 NMYHLF--QLKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
LF Q L W+ E +L P G D D V L D + F +E G
Sbjct: 4700 EAL-LFSGQFMDALQALVDWLYKVEPQLAEDQPVHG-DLDLVMNLMDAHKVFQKELG--- 4754
Query: 1744 QERVDNVNAFIE---RLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLH 1800
+R V LI+ + + L+ W + +L ++ L +
Sbjct: 4755 -KRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQA 4813
Query: 1801 RYFY-TGAEILGLIDEKHRELPEDVGL--DASTAESFHRVHTAFERELHLLGVQVQQFQD 1857
F T +L + E + L L D +S H F +++ V V
Sbjct: 4814 EVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVA 4873
Query: 1858 VATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA--DKFRFFSMARDL 1915
+ + + I++ + A ++ +L A + Q ++TA + + +L
Sbjct: 4874 MGEVILAVCHPDCITTIKHWITIIRARFEEVL-TWAKQHQQRLETALSELVANAELLEEL 4932
Query: 1916 LSWM---ESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
L+W+ E+ + Q + + P+++ V+ L+ HQ E+
Sbjct: 4933 LAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEM 4972
Score = 157 bits (397), Expect = 1e-37
Identities = 375/1913 (19%), Positives = 765/1913 (39%), Gaps = 235/1913 (12%)
Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDL---LTWIEQTITVLNSRKFANSLTG-----VQQ 339
K+ GK+ + ++ +E G D L + T + + G + Q
Sbjct: 3145 KQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQ 3204
Query: 340 QLQAFSTYRTVEKPP---KFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAW 396
QL F ++ + P K Q+ L L IQS + + + HD + +IN W
Sbjct: 3205 QLADFKMFQKEQVDPLQMKLQQVNGLGQGL--IQSAGKDCDVQGLE-HD---MEEINARW 3258
Query: 397 ESLEEAEYRRELALRNELIR----QEKLEQLARRFDRKAAMRETWLSENQRLVA-QDNFG 451
+L + +R L+ L+ Q+ LE L +WL++ + L+A Q
Sbjct: 3259 NTLNKKVAQRIAQLQEALLHCGKFQDALEPLL-----------SWLADTEELIANQKPPS 3307
Query: 452 YDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE----LEKENYHDQKRITARKDNIL 507
+ V+A ++ + ++ ++R ++ L E + D+++IT + +++
Sbjct: 3308 AEYKVVKAQIQEQKLLQR---LLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLE 3364
Query: 508 RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAE-FGKHLLEVED 565
W+ L +R+++LE L L K F + I D++ + L ++E G +++
Sbjct: 3365 SRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQQ 3424
Query: 566 LLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNM 625
+ +HK +E DI V A + + P + V+ ++I L+ + E+ +
Sbjct: 3425 QIIRHKALEEDIENHATDVHQ--AVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDR 3482
Query: 626 AAGRKAQLEQSKRLWKFFWEMDEAE--SWIKEKEQIYSSL---DYGKDLTSVLILQRKHK 680
+ A L+Q+ + F E DE E +W+ E E SS+ D+ +D +L R+H
Sbjct: 3483 CCRKAALLDQALSNARLFGE-DEVEVLNWLAEVEDKLSSVFVKDFKQD-----VLHRQHA 3536
Query: 681 ---AFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKK 737
A +E+ +++Q + +G KQ ++ +++ + D+ K
Sbjct: 3537 DHLALNEEIVNRKKNVDQAIK--NGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSK 3594
Query: 738 NLQDAENFFQ----FQGDADDLKAWLQDAHRLLS--------GEDVGQDEGATRALGKK- 784
L+ E Q FQ ++L WL++ L+ GE + Q + + L K+
Sbjct: 3595 ALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEV 3654
Query: 785 --HKDFLEELEE-SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADL-- 839
H+ L+ + E SR ++E + +A+ ++ D + + + + Q V + D
Sbjct: 3655 MEHRLVLDTVNEVSRALLELVPWRAREGLDKLVS--DANEQYKLVSDTIGQRVDEIDAAI 3712
Query: 840 -RQQRLQEALDLYTVF-GETDACELWMG----EKEKWLAEMEMPDTLEDLEVVQHRFDIL 893
R Q+ ++A D + ET + +G E+++ A++++ +++++H+ D +
Sbjct: 3713 QRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS-IDIIRHK-DSM 3770
Query: 894 DQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSA 953
D E+ + ++I G G + +++ + L +++A L SER ++ A
Sbjct: 3771 D-ELFSHRSEIFGT---------CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 3820
Query: 954 -LRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVD 1012
+ V+ + EE S WI + ++ D + Q ++ L +A + +D
Sbjct: 3821 QVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHID 3880
Query: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGE-VSQLQAFLQDLD 1071
L + QL + +PE+ E + ++ + E ++ +++ ++ + L E VSQ + D
Sbjct: 3881 KLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHD 3940
Query: 1072 DFQAWLSITQKAVASEDMPESLP----EAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV 1127
+ L + + MP +P + + + + E++ Q S++ +K GE++
Sbjct: 3941 KIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL 4000
Query: 1128 I---QG-QTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQE-FQKDAKQAEA 1182
I QG D + +L+ + W + E R L E F D
Sbjct: 4001 IGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLT 4060
Query: 1183 ILSNQEYTLAHLEPP--------DSLEAAEA------GIRKFEDFLGSM---------EN 1219
+ + + + LE P +EAAE G+ + +F+ + E
Sbjct: 4061 TIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGET 4120
Query: 1220 NRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNF 1279
+ +V +D N A NL + KE+++ +ED A +A+V +D L
Sbjct: 4121 EKPEVRKSIDEMNN--AWENL-NKTWKERLEKLED--------AMQAAVQYQDTL----- 4164
Query: 1280 LQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEG 1336
Q + W+++ KL T V D + ++ + + F E+ + +E ++ +G
Sbjct: 4165 ----QAMFDWLDNTVIKLCTMPPVGTD-LNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQG 4219
Query: 1337 KQLMDEKPQFTA--LVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHA--DLN 1392
+ ++ + T ++ + L L LW+ L + L A + + Q HA +L
Sbjct: 4220 ELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQ-HALEELM 4278
Query: 1393 KWISAMEDQLRSDDP------------GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFA 1440
W++ E+ L + P K N +LA VE VN EL E
Sbjct: 4279 SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVET-VNKAGNELLE--- 4334
Query: 1441 QVPSMGEEGGDADLSIEKR---FLDLLEPLGRRKKQLESSRAKLQ-ISRDLEDETLWVEE 1496
S G++ +E + +L+ R++QL+S+ + Q ++ED L +
Sbjct: 4335 --SSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTR 4392
Query: 1497 -RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQD- 1554
L+ S G +T + + + L +++ +L +G+ ++ + +
Sbjct: 4393 MESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGS 4452
Query: 1555 -LEERLGHLQSSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWI--GEQELYVISD 1610
E+ + L+ W + R +L +A N A ++ E W+ EQ L + S
Sbjct: 4453 KTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASP 4512
Query: 1611 E-------IPKDEEGAIVM--LKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQI 1661
+ + EE + + H Q ++ G +K L+ + +L I
Sbjct: 4513 PSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVL---------I 4563
Query: 1662 IRLQGQVDKHYAGLKDVAEERKRKLENMY-HLFQLKRETDDLEQWISEKEL-VASSPEMG 1719
L V + + + ER R L++ Q L W+ + E + S E+
Sbjct: 4564 KNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEIS 4623
Query: 1720 QDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMW 1779
D D + L K ++F + G G++ V + R + E + E L+
Sbjct: 4624 NDPDKIKLQLSKHKEFQKTLG--GKQPVYDTTIRTGRAL----KEKTLLPEDSQKLDNFL 4677
Query: 1780 ADLLELIDTRM-QLLAASYDLHRYFYTGAEIL----GLIDEKHR---ELPED--VGLDAS 1829
++ + DT + + + L + + L+D ++ +L ED V D
Sbjct: 4678 GEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLD 4737
Query: 1830 TAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALL 1889
+ H F++EL VQ + L + + ++ + QE+S W +
Sbjct: 4738 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGREL-IENSRDDTTWVKGQLQELSTRWDTVC 4796
Query: 1890 DACAGRRTQLVDTADKFRFF-SMARDLLSWMESIIRQIETQER-PRDVSSVELLMKYHQG 1947
++++L + F LL W+ + + + P D +++ L+ H+
Sbjct: 4797 KLSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKE 4856
Query: 1948 INAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRM 2007
++E + + ++ + +GE +L H + ++ R E W A+ + R+
Sbjct: 4857 FMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTW-AKQHQQRL 4915
Query: 2008 LLEVCQFSRDASVAE---AWLIAQEPYLASGD---FGHTVDSVEKLIKRHEAF 2054
+ + +A + E AW+ E L D +D V+ LI H+ F
Sbjct: 4916 ETALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTF 4968
Score = 154 bits (390), Expect = 7e-37
Identities = 331/1658 (19%), Positives = 663/1658 (39%), Gaps = 142/1658 (8%)
Query: 494 HDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLL 552
HD + I AR W+ L + + R +L+ L FQD L + W+ + + +
Sbjct: 3249 HDMEEINAR-------WNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIA 3301
Query: 553 -----SAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQV 607
SAE+ V+ +Q+ KL++ + + V + A + + + D +
Sbjct: 3302 NQKPPSAEYKV----VKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSA--ELADREK 3355
Query: 608 IQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKE--KEQIYSSLDY 665
I ++ LE + EL + AA R+ QLE L K F E E S ++++ +S
Sbjct: 3356 ITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPV 3415
Query: 666 GKDLTSVLILQRKHKAFEDELRGLDAHLEQ---IFQEAHGMVARKQFGHPQIEARIKEVS 722
G + +HKA E+++ + Q I Q + + + G + +I +
Sbjct: 3416 GTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQG--VLSEKIDSLQ 3473
Query: 723 AQWDQLKDLAAFCKKNL---QDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEG 776
A++ +++D C+K Q N F D ++ WL + LS +D QD
Sbjct: 3474 ARYSEIQDRC--CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQD-- 3529
Query: 777 ATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD-----VTHRLQALRELYQ 831
L ++H D L EE ++++Q + + + + +L ++ Y
Sbjct: 3530 ---VLHRQHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYA 3586
Query: 832 QVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME-MPDTLEDLEVVQHR 889
+ + + L++A L T F T + W+ E E+ LA T E + Q R
Sbjct: 3587 DITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQR 3646
Query: 890 FDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHLNTRWQAFQTLVSERRE 948
L +E+ +D VN + +L+E R+RE + + N +++ + +R +
Sbjct: 3647 QKELKKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVD 3706
Query: 949 AVDSAL-RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAI 1007
+D+A+ R Y + W+ + + + + + + A + D+
Sbjct: 3707 EIDAAIQRSQQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSIDIIRH 3766
Query: 1008 QARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQA-- 1065
+ +D L ++ + E+++ + Q+ E L Q + + + + Q
Sbjct: 3767 KDSMDELFSHRSEIFGTCGEEQKTV--LQEKTESLIQQYEAISLLNSERYARLERAQVLV 3824
Query: 1066 --FLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAG---IKDEIDGHQDSYQRV 1120
F + ++ W+ T+ +A +P + EQL QQ +++ I H+ ++
Sbjct: 3825 NQFWETYEELSPWIEETRALIAQ--LPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKL 3882
Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQ-EFQKDAKQ 1179
+ G ++ + + E ++ ++ + + + + R+ L + + + + +
Sbjct: 3883 LKIGPQLKELNPE-EGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDK 3941
Query: 1180 AEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDS----GNKLV 1235
E +L E + L P + A IR+ S +K+ ++ G +L+
Sbjct: 3942 IEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001
Query: 1236 -----AEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLEL-QNFLQNCQELTLW 1289
A+ +L + +I++K+ + +A+E + D LEL + F + L
Sbjct: 4002 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4061
Query: 1290 INDKLLTSQDVSYD-EARNLHNKWLKHQAFVAELASHEG-----WLENIDAEGKQLM--- 1340
I D +QD+ +D E+ + +K Q AE E LE I G L+
Sbjct: 4062 IKD----TQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLIFAC 4117
Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISA 1397
EKP+ V + ++ ++ W+ L T KE+ + L A + ++ Q T + W+
Sbjct: 4118 GETEKPE----VRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDN 4173
Query: 1398 MEDQLRSDDP-GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGD-ADLS 1455
+L + P G DL +V L ++K + +V ++ E+ +L Q M ++ D D
Sbjct: 4174 TVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRD 4233
Query: 1456 IEKRFL--------DLLEPLGRRKKQLESSRAKL-QISRDLEDETLWVE--ERLPLAQSA 1504
I + L +L E + R+ +LE + L Q LE+ W+ E L AQ
Sbjct: 4234 IIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRP 4293
Query: 1505 DYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEA-AEIDCQDLEERLGHLQ 1563
G + + +++ + K+ L+N++L H VE V + G +L+E+ A D L RL +
Sbjct: 4294 ISG-DPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMN 4352
Query: 1564 SSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWIGEQELYVISDEIPKD-EEGAIV 1621
W+ + + R Q+L+ +AQ ++ + ++ + E + + + E A
Sbjct: 4353 QCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETARE 4412
Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEG-----EQIIRLQGQVDKHYAGLK 1676
L H+ ++ QL + + +L + G EQ + L +++ + +
Sbjct: 4413 QLDTHMELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVAL---LEQKWHVVS 4469
Query: 1677 DVAEERKRKLENMYHLF-QLKRETDDLEQWISEKEL---VASSPEMGQDFDHVTLLRDKF 1732
EERK KLE +L + + + W++ E +AS P + + V ++
Sbjct: 4470 SKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL--ILNTVLSQIEEH 4527
Query: 1733 RDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQL 1792
+ FA E A + ++ + + + I + W +++ R +
Sbjct: 4528 KVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRS 4587
Query: 1793 LAASYDLHRYFYTGAEILGLID-----EKHRELPEDVGLDASTAESFHRVHTAFERELHL 1847
L + + F+ + LID E H + ++ D + H F++ L
Sbjct: 4588 LDDARKRAKQFHEAWK--KLIDWLEDAESHLDSELEISNDPDKIKLQLSKHKEFQKTLG- 4644
Query: 1848 LGVQVQQFQDVATRLQTAYAG-----EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902
Q D R A E ++ + N EV W + R+ +L +
Sbjct: 4645 ---GKQPVYDTTIRTGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEA 4701
Query: 1903 A-DKFRFFSMARDLLSWMESIIRQI-ETQERPRDVSSVELLMKYHQGINAEIETRSKNFS 1960
+F + L+ W+ + Q+ E Q D+ V LM H+ E+ R+
Sbjct: 4702 LLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQ 4761
Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRD-AS 2019
G L++ + ++ +LQ++ +R + + ++ RL L+ + RD
Sbjct: 4762 VLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVFRDTVH 4821
Query: 2020 VAEAWLIAQEPYLA-SGDFGHTVDSVEKLIKRHEAFEK 2056
+ WL E L G ++++ LI H+ F K
Sbjct: 4822 MLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEFMK 4859
Score = 134 bits (336), Expect = 1e-30
Identities = 259/1325 (19%), Positives = 533/1325 (40%), Gaps = 118/1325 (8%)
Query: 287 GKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQT---ITVLNSRKFANSLTGVQQQLQA 343
G+RV + ID AI+ ++Y A L W+ +T + L + T Q Q+Q
Sbjct: 3702 GQRVDE-IDAAIQRS---QQYEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQK 3757
Query: 344 FSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAE 403
+ + E LF+ +S +++ + + + ESL +
Sbjct: 3758 AFSIDIIRHKDSMDE-------LFSHRS-------EIFGTCGEEQKTVLQEKTESLIQQY 3803
Query: 404 YRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQ-DNFGYDLAAVEAAKK 462
L R E+ + L +F W+ E + L+AQ + D + ++
Sbjct: 3804 EAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQE 3863
Query: 463 KHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQ 522
+ + A ++ + L + +L++ N + + + + +++ ++E ++ R
Sbjct: 3864 EMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRAL 3923
Query: 523 RLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVE-DLLQKHKLMEADIAIQG 581
L+ ++ + I+ M E +L S L+ E D +++ ++
Sbjct: 3924 ALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVEL 3983
Query: 582 DKVKAITAATLKFTE---GKGYQPCDPQV----IQDRISHLEQCFEELSNMAAGRKAQ-L 633
+K++ A + E G+ Q D + IQD++ + +E++ A R+ + L
Sbjct: 3984 EKLQPSFEALKRRGEELIGRS-QGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL 4042
Query: 634 EQSKRLWKFFWEMDEAESWIKEKEQIYSSLDY-GKDLTSVLILQRKHKAFEDELRGLDAH 692
+ + KF+++M + IK+ + I L+ G D + + + ++E GL
Sbjct: 4043 DVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEE 4102
Query: 693 LEQI-FQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQG 750
LE I A + A + P++ I E++ W+ L + L+DA + Q+Q
Sbjct: 4103 LEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQD 4162
Query: 751 DADDLKAWLQDAH-RLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGF 809
+ WL + +L + VG D + + K+F E+ + + ME L Q +
Sbjct: 4163 TLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELM 4222
Query: 810 PEEFRDSPD---VTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMG 865
++ D D + L L+ L++ + + RQ +L+ AL F + W+
Sbjct: 4223 LKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLT 4282
Query: 866 EKEKWL-AEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGH-PRSR 923
E+ L A+ + + +EV + +L ++ ++ VN A N L+ES +
Sbjct: 4283 HTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDAS 4342
Query: 924 EVKQYQDHLNTRWQAFQTLVSERREAVDSALR-VHNYCVDCEETSKWITDKTKVVESTKD 982
++ + +N W++ ER + + S L+ + + E+ +T + ++K
Sbjct: 4343 SLRSRLEAMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKP 4402
Query: 983 LGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ---KEDIGQRQKH- 1038
G G+ R+ + + +++ A E QL+D ++D G K
Sbjct: 4403 TG----GLPETAREQLDTHME---LYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTE 4455
Query: 1039 -----LEELWQGLQQSLQGQEDLLGEVSQLQA-FLQDLDDFQAWLSITQKAVASEDMPES 1092
LE+ W + ++ ++ L E L F L +F WL++ ++++ P
Sbjct: 4456 QSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSL 4515
Query: 1093 -LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151
L +++H +E++ H+D + ++G ++ + +L+ L + + W
Sbjct: 4516 ILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWE 4575
Query: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQA----EAILSNQEYTLAHLEP-------PDSL 1200
+ + R +L + +K AKQ + ++ E +HL+ PD +
Sbjct: 4576 KVVQRSIERGRSL------DDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKI 4629
Query: 1201 EAAEAGIRKFEDFLGSMENNRD-----------KVLSPVDSGNKLVAEGNLYSDKIKEKV 1249
+ + ++F+ LG + D K L P DS KL + + ++++K
Sbjct: 4630 KLQLSKHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDS-QKL----DNFLGEVRDKW 4684
Query: 1250 QLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLW---INDKLLTSQDVSYDEAR 1306
+ + + K +EA + F+ Q L W + +L Q V + +
Sbjct: 4685 DTVCGKSVERQHKLEEALLFSGQ------FMDALQALVDWLYKVEPQLAEDQPV-HGDLD 4737
Query: 1307 NLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQA 1366
+ N H+ F EL G ++ + G++L++ T V +L+ L WD +
Sbjct: 4738 LVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCK 4797
Query: 1367 TTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAK----- 1420
+ K L A + +++ T L +W+S E LR D T + L
Sbjct: 4798 LSVSKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHKEF 4857
Query: 1421 LKRVEDQ-VNVRKE-ELGELFAQV--PSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLES 1476
+K+VE++ V+V +GE+ V P I RF ++L + +++LE+
Sbjct: 4858 MKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLET 4917
Query: 1477 SRAKLQISRDLEDETL----WVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTP 1532
+ ++L + +L +E L W E L N+ V+ + ++QT E+ P
Sbjct: 4918 ALSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQP 4977
Query: 1533 RVEDV 1537
V+ V
Sbjct: 4978 DVDRV 4982
Score = 119 bits (299), Expect = 2e-26
Identities = 319/1693 (18%), Positives = 678/1693 (40%), Gaps = 149/1693 (8%)
Query: 421 EQLARRFDRKAAMRETWLSENQRLVAQD-NFGYDLAAVEAAKKKHE----AIETDTAAYE 475
+Q + FD TWL + Q A++ L +++ +++E ++ + +YE
Sbjct: 2734 QQFQQMFDEL----RTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYE 2789
Query: 476 ERVRALEDLAQELE--KENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKL 533
V E L + +E Q ++ K++ W L + R+ RL+ + +
Sbjct: 2790 VIVAEGESLLLSVPPGEEKRTLQNQLVELKNH----WEELSKKTADRQSRLKDCMQKAQK 2845
Query: 534 FQDMLHS-IDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATL 592
+Q + + W+++ KA + +++E L + K M ++ + ++ + +A
Sbjct: 2846 YQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAAD 2905
Query: 593 KFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKF---FWEMDE 648
D I+D + + Q + ++ + LE+ ++RL +F F +++
Sbjct: 2906 ILINSS---EADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEK 2962
Query: 649 AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
K + +I+ +L G S L+ K +A ++ L+ L+ ++ + G+V
Sbjct: 2963 KVEGAKHQLEIFDAL--GSQACSNKNLE-KLRAQQEVLQALEPQVDYLRNFTQGLVEDAP 3019
Query: 709 FGHPQIEARIKEVSAQWDQLK---DLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRL 765
G + + AQ + L+ + + C E QF ++ + L D
Sbjct: 3020 DGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDDE 3079
Query: 766 LSGED-VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE--FRDSPDVTHR 822
L G +G+D + ++ + + FL ++ + +E E + + EE D +
Sbjct: 3080 LDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRE 3139
Query: 823 LQALRELYQQVVAQADLRQQRLQEAL----DLYTVFGETDACELWMGEKE--KWLAEMEM 876
L+AL + ++ + RQ++L+ L D Y + E E +W+ E+
Sbjct: 3140 LEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEV 3199
Query: 877 P---DTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRS--REVKQYQDH 931
L D ++ Q +++ L ++ VN L++S + ++ +
Sbjct: 3200 EIINQQLADFKMFQK------EQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEE 3253
Query: 932 LNTRWQAFQTLVSERREAVDSALRVHNYCVDC-EETSKWITDKTKVVESTKDLGRDLAGI 990
+N RW V++R + AL D E W+ D +++ + K + +
Sbjct: 3254 INARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLLSWLADTEELIANQKPPSAEYKVV 3313
Query: 991 IAIQRKLSGLERDVAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQS 1049
A ++ L+R + +A VD L+ E ++ S +E I + + LE W L
Sbjct: 3314 KAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTELLSK 3373
Query: 1050 LQGQ----EDLLGEVSQLQAFLQDLDDFQAWLSITQKAVA-SEDMPESLPEAEQLLQQHA 1104
+ ED+L Q + + DF LS+T+K +A SE + + +Q + +H
Sbjct: 3374 AAARQKQLEDILVLAKQFHETAEPISDF---LSVTEKKLANSEPVGTQTAKIQQQIIRHK 3430
Query: 1105 GIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTL 1164
++++I+ H + + G+ + + E +L ++++ L ++ + ++ L
Sbjct: 3431 ALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALL 3490
Query: 1165 AQCLGFQE-FQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NN 1220
Q L F +D + L+ E L+ + D + + R+ D L E N
Sbjct: 3491 DQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ--DVLHRQHADHLALNEEIVNR 3548
Query: 1221 RDKVLSPVDSGNKLVAEGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNF 1279
+ V + +G L+ + I+EK+ I+ R+ + +A L +L
Sbjct: 3549 KKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATK 3608
Query: 1280 LQNC-QELTLW---INDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAE 1335
Q+ +ELT W + ++L TS S + + + E+ H L+ ++
Sbjct: 3609 FQSTYEELTGWLREVEEELATSGGQS-PTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEV 3667
Query: 1336 GKQLMDEKPQFTALVSQKLEA-LHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLN-K 1393
+ L++ P KL + + + + T ++ + AA + + AD
Sbjct: 3668 SRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELA 3727
Query: 1394 WISAMEDQLRSDDP---GKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSM-GEEG 1449
W++ + +L + P +D T+ + K ++ + K+ + ELF+ + G G
Sbjct: 3728 WVAETKRKLMALGPIRLEQDQTTAQLQVQKAFSID--IIRHKDSMDELFSHRSEIFGTCG 3785
Query: 1450 GDADLSIEKRFLDLLEPL-------GRRKKQLESSRAKL-QISRDLEDETLWVEE-RLPL 1500
+ ++++ L++ R +LE ++ + Q E+ + W+EE R +
Sbjct: 3786 EEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALI 3845
Query: 1501 AQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLG 1560
AQ + + ++ ++ + L+ I H P ++ +L+ G QL E + + +EE+
Sbjct: 3846 AQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQ 3905
Query: 1561 HLQSSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWIGEQELY--------VISDE 1611
++ + +++E R L +A +++ Q D+ E + E +I E
Sbjct: 3906 KAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAE 3965
Query: 1612 IPK------DEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQ 1665
+ K D + A V L+ + Q + E R ++L R+QG + ++I
Sbjct: 3966 VDKIRECISDNKSATVELE---KLQPSFEALKRRGEELIGRSQG--ADKDLAAKEIQDKL 4020
Query: 1666 GQVDKHYAGLKDVAEERKRKLENMYHLFQ------------LKRETD---DLEQWISEKE 1710
Q+ + +K AEER+ K ++ L + +K D DLE +
Sbjct: 4021 DQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPS 4080
Query: 1711 LVASSPEMGQDFDHVTLLRDKFRDFARETG-----AIGQERVDNVNAFIERLIDAGHSEA 1765
++ E + T + +F R G A G+ V I+ + +A
Sbjct: 4081 IIKQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNA----- 4135
Query: 1766 ATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVG 1825
W + LN+ W + LE ++ MQ D + + + + K +P VG
Sbjct: 4136 -----W-ENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVI---KLCTMP-PVG 4185
Query: 1826 LDASTAESFHRVHTAFERELHLLGVQVQQFQDVA-TRLQTAYAGEKAEAIQNKEQEVSAA 1884
D +T + F+ E++ +++++ L+ A + I+ E+
Sbjct: 4186 TDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHL 4245
Query: 1885 WQALLDACAGRRTQLVDTADKFRFFSMA-RDLLSWMESIIRQIETQERP--RDVSSVELL 1941
W+ L + A R+ +L F A +L+SW+ ++ Q RP D +E+
Sbjct: 4246 WENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQ-RPISGDPKVIEVE 4304
Query: 1942 MKYHQGINAEIETRSKNFSACLELGESLLQRQ-HQASEEIREKLQQVMSRRKEMNEKWEA 2000
+ H + ++ + G LL+ + +R +L+ + + + +K E
Sbjct: 4305 LAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTEE 4364
Query: 2001 RWERLRMLLEVCQ 2013
R ++L+ L+ Q
Sbjct: 4365 REQQLQSTLQQAQ 4377
Score = 117 bits (293), Expect = 1e-25
Identities = 271/1399 (19%), Positives = 558/1399 (39%), Gaps = 137/1399 (9%)
Query: 417 QEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEE 476
Q+ ++ A F E ++ ENQ ++ + AK+++EA++ +T ++
Sbjct: 1596 QDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQK 1655
Query: 477 RVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
+ A + E E K + K I L ++ + S Q L +++L
Sbjct: 1656 ELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA 1715
Query: 537 MLH--SIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
L ++D D + E +++ + K ++ Q T + F
Sbjct: 1716 SLEKGALDTTDGYMGVNQAPE------KLDKQCEMMKARHQELLSQQQNFILATQSAQAF 1769
Query: 595 TEGKGYQ--PCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSK----RLWKFFWEMDE 648
+ G+ P + Q++Q ++ L+ E+ S A +A+L+Q + L KF + E
Sbjct: 1770 LDQHGHNLTPEEQQMLQQKLGELK---EQYSTSLAQSEAELKQVQTLQDELQKFLQDHKE 1826
Query: 649 AESWIKEKEQIYSSLDYGKDLTSVL--ILQRKHKAFED------ELRGLDAHLEQIFQEA 700
ESW++ E+ ++ G L +L+R+ ED +LR + +++
Sbjct: 1827 FESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886
Query: 701 HGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKA 757
+ K+ ++ ++K+ + ++ L +L + QFQ AD L+A
Sbjct: 1887 NSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQA 1946
Query: 758 WLQ----DAHRLLSGEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPE-E 812
W+Q + +LLS + V D G + K EEL E + +E L++ A+ E E
Sbjct: 1947 WMQACEANVEKLLS-DTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIE 2005
Query: 813 FRDSPDVTH---RLQALRELYQQVVAQADLRQQRLQEAL-DLYTVFGETDACELWMGEKE 868
+PD H ++ +Q + R LQ+A+ +V ++ +GE E
Sbjct: 2006 GEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVE 2065
Query: 869 KWLAEMEMPDTLEDLEVVQHRFDI---LDQEMKTLMTQIDGVNLAANSLVESGHPRSREV 925
+ L ++ V+Q L Q++ + ++ +E+ + V
Sbjct: 2066 QNLEGKQVSSLSSG--VIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAV 2123
Query: 926 KQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS----KWITDKTKVVESTK 981
Q L Q F+ L +++E S ++ E S +++ +K++++ S
Sbjct: 2124 --LQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181
Query: 982 DLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEE 1041
+D+ +++ L ++ Q +D LE +L S D+ Q Q ++
Sbjct: 2182 QPDQDITHFF---QQIQELNLEMEDQQENLDTLEHLVTEL--SSCGFALDLCQHQDRVQN 2236
Query: 1042 L---WQGLQQSLQGQE-DLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAE 1097
L + LQ++++ +E D QL F + + FQ WL T+ ++ + S E E
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELE 2296
Query: 1098 QLLQQHAGIKDEIDGHQDSYQRVKESG---EKVI--------QGQTDPEYLLLGQR---- 1142
+ ++ + D+ + + G E +I QG+T +G
Sbjct: 2297 KQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSV 2356
Query: 1143 ---------------LEGLDTGWNALGRMWESRSHTLAQCLG-FQEFQKDAKQAEAILSN 1186
+ ++ + LG + R +L L +E K+A L +
Sbjct: 2357 NGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLES 2416
Query: 1187 QEYTLAHLE---PPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDS-GNKLVAEGNLYS 1242
+E L ++ P E +A + FL +E N K+ ++ LV N
Sbjct: 2417 KEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPN--- 2473
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLE-----LQNFLQNCQELTLWINDKLL-- 1295
+ E + I++ E+A E +V + LE L F +L W+ +K L
Sbjct: 2474 SQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMM 2533
Query: 1296 -TSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM---DEKPQFTALVS 1351
+S D L+ + + Q + E + E ++ + ++ + T+ V
Sbjct: 2534 GVLGPLSID-PNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQ 2592
Query: 1352 QKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRSDDP-GK 1409
++L+++++ W EL ++ + A + Q DL++ + A+ +L
Sbjct: 2593 KELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAIST 2652
Query: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL--SIEKRFLDLLEPL 1467
+V + L + + + E+ E + G+ L ++KR + PL
Sbjct: 2653 QPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKKRLETVALPL 2712
Query: 1468 -------GRRKKQLESSRAKLQISRDLEDE-TLWVEER-LPLAQSADYGTNLQTVQLFMK 1518
R +L+++ A Q + + DE W++++ A++ L+ +Q ++
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772
Query: 1519 KNQTLQNEILGHTPRVEDVLQRGQQLVEAAE--IDCQDLEERLGHLQSSWDRLREAAAGR 1576
+N+ Q + H+ E ++ G+ L+ + + + L+ +L L++ W+ L + A R
Sbjct: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 2832
Query: 1577 LQRLRDA-NEAQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRHLRQQ 1630
RL+D +AQ+Y ++ WI + EL V D P E +++ K L +
Sbjct: 2833 QSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLD--PVQLESSLLRSKAMLNE- 2889
Query: 1631 RAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMY 1690
VE ++ L S A L+++ + + I + ++++ + V EE + K ++
Sbjct: 2890 --VEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN---MDAVTEELQAKTGSLE 2944
Query: 1691 HLFQLKRETDDLEQWISEK 1709
+ Q RE + + I +K
Sbjct: 2945 EMTQRLREFQESFKNIEKK 2963
Score = 108 bits (271), Expect = 4e-23
Identities = 332/1869 (17%), Positives = 737/1869 (39%), Gaps = 182/1869 (9%)
Query: 333 SLTGVQQQLQAFSTYRTVEKPPKFQEKGN--LEVLLFTIQSRMRANN--QKVYTPHDGK- 387
+L QQ Q F RT + Q+ N + L +QS+++ N QK H G
Sbjct: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSY 2788
Query: 388 --LVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRF-DRKAAMRET------- 436
+V++ S+ E +R L+N+L+ + E+L+++ DR++ +++
Sbjct: 2789 EVIVAEGESLLLSVPPGEEKR--TLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKY 2846
Query: 437 ---------WLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQE 487
W+ + + +++ D +E++ + +A+ + + L A
Sbjct: 2847 QWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADI 2906
Query: 488 LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEI 547
L + D+ I K I + + E LQ++ LE + FQ+ +I+
Sbjct: 2907 LINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIE----- 2961
Query: 548 KAHLLSAEFGKHLLEVEDLLQKHKLMEADIA---IQGDKVKAITAAT---LKFTEGKGYQ 601
E KH LE+ D L ++ Q + ++A+ FT+G
Sbjct: 2962 ----KKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVED 3017
Query: 602 PCD----PQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKE 657
D Q++ ++ E + +G + + + +F + E S + + +
Sbjct: 3018 APDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLD 3077
Query: 658 QIYSSLD-YGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ----FG-H 711
+ G+D S+ + F +++ L +E E M+ + G
Sbjct: 3078 DELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLK 3137
Query: 712 PQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRL-----L 766
++EA K+ ++ K + L E+F++ +D ++A L
Sbjct: 3138 RELEALNKQCGKLTERGKARQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGT 3197
Query: 767 SGEDVGQDEGATRALGKKHKDFLE-ELEESRGVMEHLEQQA------QGFPEEFRDSPDV 819
E + Q + K+ D L+ +L++ G+ + L Q A QG D ++
Sbjct: 3198 EVEIINQQLADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEH---DMEEI 3254
Query: 820 THRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACE---LWMGEKEKWLAEMEM 876
R L + Q +AQ LQEAL F DA E W+ + E+ +A +
Sbjct: 3255 NARWNTLNKKVAQRIAQ-------LQEALLHCGKF--QDALEPLLSWLADTEELIANQKP 3305
Query: 877 PDTLEDLEVVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE-VKQYQDHL 932
P + +VV+ + +L + + +D + + +S RE + + L
Sbjct: 3306 PSA--EYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQLESL 3363
Query: 933 NTRWQAFQTLVSERREAVDSALRV-HNYCVDCEETSKWITDKTKVVESTKDLGRDLAGII 991
+RW + + R++ ++ L + + E S +++ K + +++ +G A I
Sbjct: 3364 ESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQTAKIQ 3423
Query: 992 AIQRKLSGLERDVAAIQARVDALERESQQLMD-SHPEQKEDIGQRQKHLEELWQGLQQSL 1050
+ LE D+ V + Q L + P ++ + ++ L+ + +Q
Sbjct: 3424 QQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRC 3483
Query: 1051 QGQEDLLGE-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHA---GI 1106
+ LL + +S + F +D + WL+ + ++S + + + + L +QHA +
Sbjct: 3484 CRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDF--KQDVLHRQHADHLAL 3541
Query: 1107 KDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ 1166
+EI + + + ++G+ +++ T E LL+ ++L+G+ T + + TL Q
Sbjct: 3542 NEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQ 3601
Query: 1167 CLGFQ-EFQKDAKQAEAILSNQEYTLAHL--EPPDSLEAAEAGIRKFEDFLGSME----- 1218
+FQ ++ L E LA + P + + R+ E ME
Sbjct: 3602 ARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVL 3661
Query: 1219 ---NNRDKVLSPV------DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQE 1265
N + L + + +KLV++ N L SD I ++V I+ +++ + Q
Sbjct: 3662 DTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQA 3721
Query: 1266 ASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASH 1325
A L E + L + L ++ T+ + +A ++ ++H+ + EL SH
Sbjct: 3722 ADAELAWVAETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI--IRHKDSMDELFSH 3776
Query: 1326 EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRL 1385
+ E ++ ++ +K E+L + ++ + E+ L A+ +
Sbjct: 3777 RSEIFGTCGEEQK---------TVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQF 3827
Query: 1386 -QTHADLNKWIS---AMEDQLRSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQ 1441
+T+ +L+ WI A+ QL S P D + + +++++ + + K + +L
Sbjct: 3828 WETYEELSPWIEETRALIAQLPS--PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKI 3885
Query: 1442 VPSMGEEGGDADLSIEKRF-------LDLLEPLGRRKKQLESSRAKLQISRDLED----- 1489
P + E + +E+++ + E + +R L+ + ++ + D
Sbjct: 3886 GPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPM 3945
Query: 1490 ----ETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLV 1545
E L R+P A+ + ++ + N++ E+ P E + +RG++L+
Sbjct: 3946 LETLENLSSRLRMPPLIPAE----VDKIRECISDNKSATVELEKLQPSFEALKRRGEELI 4001
Query: 1546 EAAE-----IDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAW 1599
++ + ++++++L + W+ ++ A R + D E A++++ D
Sbjct: 4002 GRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTT 4061
Query: 1600 IGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLAS-----RAQGLLSAG 1654
I + + V E P + I K+ + +++ + + A + + G
Sbjct: 4062 IKDTQDIVHDLESPGIDPSII---KQQVEAAETIKEETDGLHEELEFIRILGADLIFACG 4118
Query: 1655 HPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQWISEKEL-V 1712
E ++ + +++ + L +ER KLE+ M Q + + W+ + +
Sbjct: 4119 ETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKL 4178
Query: 1713 ASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAAT--IAE 1770
+ P +G D + V ++ ++F E Q ++ +N E ++ E I E
Sbjct: 4179 CTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-QQIEMEKLNHQGELMLKKATDETDRDIIRE 4237
Query: 1771 WKDGLNEMWADLLELIDTRMQLL-AASYDLHRYFYTGAEILGLID--EKHRELPEDVGLD 1827
L +W +L E I R L A L ++ + E++ + E+ + + D
Sbjct: 4238 PLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGD 4297
Query: 1828 ASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQA 1887
E H + ++ V+ L + AG+ A +++++ + ++ W++
Sbjct: 4298 PKVIEVELAKHHVLKNDVLAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWES 4357
Query: 1888 LLDACAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYH 1945
+L R QL T + + F S D L + + Q+ + + + + H
Sbjct: 4358 VLQKTEEREQQLQSTLQQAQGFHSEIEDFLLELTRMESQLSASKPTGGLPETAREQLDTH 4417
Query: 1946 QGINAEIETRSKNFSACLELGE-SLLQRQHQASEEIREKLQQVMSRR-KEMNEKWEARWE 2003
+ ++++ + + ++ L+ G LL R S E+ ++ ++ ++ K E R
Sbjct: 4418 MELYSQLKAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKS 4477
Query: 2004 RLRMLLEVC-QFSRDASVAEAWL-IAQEPYLASGDFGHTVDSVEKLIKRHEAFEKSTASW 2061
+L L + +F WL +A++ + +++V I+ H+ F +
Sbjct: 4478 KLEEALNLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFANEVNAH 4537
Query: 2062 AERFAALEK 2070
++ L++
Sbjct: 4538 RDQIIELDQ 4546
Score = 107 bits (267), Expect = 1e-22
Identities = 323/1777 (18%), Positives = 666/1777 (37%), Gaps = 244/1777 (13%)
Query: 391 DINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNF 450
D+ R E + + R + IRQ +LE + A T + + AQ
Sbjct: 1241 DLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEM 1300
Query: 451 GYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLW 510
E ++ E + TA + E +E +L++ Q+ T KD L+L
Sbjct: 1301 -MKPGQAEDSRVLSEQLSQQTALFAE----IERNQTKLDQCQKFSQQYSTIVKDYELQLM 1355
Query: 511 SYL------QELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVE 564
+Y Q+ RR+ L ++ A+ + F D+ + L +H+ +
Sbjct: 1356 TYKAFVESQQKSPGKRRRMLSSSDAITQEFMDL--------RTRYTALVTLTTQHVKYIS 1407
Query: 565 DLLQK----HKLMEADIAIQGDKVKAI---TAATLKFTEGKGYQPCDPQVIQDRISHLEQ 617
D L++ K++E + +KVK + + + T+GK + + LEQ
Sbjct: 1408 DALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQ 1467
Query: 618 CFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQR 677
+ LS +K Q+ ++ + + F + KEK+QI L+
Sbjct: 1468 --QVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLN------------A 1513
Query: 678 KHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKK 737
+KA+ D G L+Q+ + Q H Q +Q K
Sbjct: 1514 LNKAYHDLCDGSANQLQQL---------QSQLAH------------QTEQ---------K 1543
Query: 738 NLQDAENFFQFQGDADDLKAWLQDAHRLLSGED---VGQDEGATRALGKKHKDFLEELEE 794
LQ +N Q +DL +W+ A R L+G QD A + KD ++++
Sbjct: 1544 TLQKQQNTCHQQ--LEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQN 1601
Query: 795 SRGVMEHLEQQAQGFPEEF------RDSPDVTHRLQALRELYQQVVAQADLRQQRLQEAL 848
+ + +GF EE R+ + +L +E Y+ + + + Q+ L+EA+
Sbjct: 1602 RATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAV 1661
Query: 849 ---------------DLYTVFGETDACELWM-------GEKEKWLAEMEM---------- 876
+L + DA W+ G+ L ME
Sbjct: 1662 TSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGA 1721
Query: 877 PDTLEDLEVVQHRFDILDQEM-------KTLMTQIDGVNLAANS----LVESGHPRSREV 925
DT + V + LD++ + L++Q LA S L + GH + E
Sbjct: 1722 LDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEE 1781
Query: 926 KQ-YQDHLNTRWQAFQTLV----SERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980
+Q Q L + + T + +E ++ + + D +E W+ K +E+
Sbjct: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841
Query: 981 KDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKE-----DIGQR 1035
G + ++ ++ DV + + + + Q+++D KE +IG
Sbjct: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 1901
Query: 1036 QKHLEELWQGLQQSLQGQEDLLGE-----VSQLQAFLQDLDDFQAWLSITQ---KAVASE 1087
K + +L + LG + Q F D QAW+ + + + S+
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961
Query: 1088 DMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKV--IQGQTDPEYLLLGQRLEG 1145
+ ++ L +++E+ HQ +++++ + I+G+ P++ + + +
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDS 2021
Query: 1146 LDTGWNALGRMWESRS-----------------HTLAQCLGFQEFQKDAKQA-------- 1180
+ + + +L RS +L Q +G E + KQ
Sbjct: 2022 ILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVI 2081
Query: 1181 -EAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGS-----MENNRDKVLSPVDSGNKL 1234
EA+ +N + SLEA + +F + S ++ +V +
Sbjct: 2082 QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQ 2141
Query: 1235 VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLL----RDNLELQNFLQNCQELTLWI 1290
E K+ + ++ E K + + S +L + + ++ +F Q QEL L +
Sbjct: 2142 QQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEM 2201
Query: 1291 NDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL---MDEKPQFT 1347
D Q + D +L + L F +L H+ ++N+ + +L + E+ +
Sbjct: 2202 ED-----QQENLDTLEHLVTE-LSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDA 2255
Query: 1348 ALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDP 1407
+ ++L+ +L Q KE + +S + +L K I ++ L DD
Sbjct: 2256 SSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS----MSAKELEKQIEHLKSLL--DDW 2309
Query: 1408 GKDLTSVNRMLAKLKRVEDQVN--VRKEELGELFAQVPSMGEEGG--------------D 1451
T V + K +E+ + + G+ + +PS+G G
Sbjct: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369
Query: 1452 ADLS-IEKRFLDLLEPLGRRKKQLESSRAKL-QISRDLEDETLWVEERLPLAQSAD---Y 1506
D+S + ++ L L R++ L++ ++ ++ ++ W+E + + +S D
Sbjct: 2370 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2429
Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ--RGQQLVEAAEIDCQDLEERLGHLQS 1564
T +TV+ + N+ E+ ++P+++ V + G + + ++ ++ L S
Sbjct: 2430 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2489
Query: 1565 SWDRLREAAAGRLQRLRD-ANEAQQYYLDADEAEAWIGEQELYV-ISDEIPKDEEGAIVM 1622
W+R E R ++L + A+ + + W+ E+EL + + + D
Sbjct: 2490 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 2549
Query: 1623 LKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQ---VDKHYAGLKDVA 1679
++ + E + +QL AQG+L+ ++Q + +++ + L D
Sbjct: 2550 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 2609
Query: 1680 EERKRKLE------NMYH--LFQLKRETDDLEQWISEKELVASSPE-MGQDFDHVTLLRD 1730
R +++ Y L L + + Q +S + +++ PE + Q + + +R
Sbjct: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669
Query: 1731 KFRDFARETGAIGQERVDNVNAFI--ERLIDAGHSEAATIAEWKDGLNEMWADLLELIDT 1788
E Q D ++ I + L D T+A GL ++ AD +
Sbjct: 2670 DLEQLDHEVKE-AQTLCDELSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRI----N 2724
Query: 1789 RMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDA--STAESFHRVHTAFERELH 1846
R+Q AS + + E+ +D+K + ++ + A +S + + F++ L+
Sbjct: 2725 RLQAALASTQQFQQMFD--ELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782
Query: 1847 L-LGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADK 1905
G + + L + GE+ +QN+ E+ W+ L A R+++L D K
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQK 2842
Query: 1906 FRFFSM-ARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLE 1964
+ + DL+ W+E ++ D +E + + + E+E R
Sbjct: 2843 AQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVEKRRSLLEILNS 2902
Query: 1965 LGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEAR 2001
+ L+ + IR++ + + E+ +A+
Sbjct: 2903 AADILINSSEADEDGIRDEKAGINQNMDAVTEELQAK 2939
Score = 98.2 bits (243), Expect = 8e-20
Identities = 313/1620 (19%), Positives = 627/1620 (38%), Gaps = 241/1620 (14%)
Query: 578 AIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSK 637
A G +K I T + K Q D +V+ +++S F E+ + +L+Q +
Sbjct: 1282 ACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIER----NQTKLDQCQ 1337
Query: 638 RL-----------------WKFFWEMDEAESWIKEKEQIYSS-------LDYGKDLTSVL 673
+ +K F E + +S K + + SS +D T+++
Sbjct: 1338 KFSQQYSTIVKDYELQLMTYKAFVESQQ-KSPGKRRRMLSSSDAITQEFMDLRTRYTALV 1396
Query: 674 ILQRKH-KAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLA 732
L +H K D LR L+ E++ +E + + +++V + LA
Sbjct: 1397 TLTTQHVKYISDALRRLEEE-EKVVEE-------------EKQEHVEKVKELLGWVSTLA 1442
Query: 733 AFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGK------KHK 786
+N Q + + D KA L+ ++LS E + E + A+ KH
Sbjct: 1443 ----RNTQGKATSSETKESTDIEKAILEQ--QVLSEELTTKKEQVSEAIKTSQIFLAKHG 1496
Query: 787 DFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
L E E+ + + +Q + + D D + L++L Q+ Q + Q+ LQ+
Sbjct: 1497 HKLSEKEKKQ-----ISEQLNALNKAYHDLCDGS--ANQLQQLQSQLAHQTE--QKTLQK 1547
Query: 847 ALDLYTVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQ-HRFDILD--QEMKTLMTQ 903
+ T + + W+G+ E+ LA + T +DL +Q ++ D+ D +++ T
Sbjct: 1548 QQN--TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATS 1605
Query: 904 IDGVNLAANSLVESGHPR--SREVKQYQDHLNTRWQAFQTLVSERR-------EAVDSAL 954
V +E + RE+ ++ L+ + ++ L E R EAV SAL
Sbjct: 1606 FATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSAL 1665
Query: 955 RVHNY----CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG----------- 999
+ + E K I V S G L + +LSG
Sbjct: 1666 QQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTT 1725
Query: 1000 ------------LERDVAAIQARVDAL----------ERESQQLMDSH-----PEQKEDI 1032
L++ ++AR L + +Q +D H PE+++ +
Sbjct: 1726 DGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQML 1785
Query: 1033 GQRQKHLEELWQ-GLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPE 1091
Q+ L+E + L QS + + +LQ FLQD +F++WL ++K + +
Sbjct: 1786 QQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGG 1845
Query: 1092 SLPEA-EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQT------DPEYL--LLGQR 1142
S PE LL++ +++ H+ + V SG+KV+ + +P + L+ +
Sbjct: 1846 SSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK 1905
Query: 1143 LEGLDTGWNALGRMWESRSHTLAQCLG-FQEFQKDAKQAEAILSNQEYTLAHL------E 1195
L+ + AL L LG + +FQ A +A + E + L
Sbjct: 1906 LKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVAS 1965
Query: 1196 PPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDR 1255
P L+ A ++ ++ L + +K+ ++ E ++E I
Sbjct: 1966 DPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSH 2025
Query: 1256 HRKNNEKAQEASVLLRDNL--------ELQNFLQNCQELTLWINDKLLTSQDVSYDEARN 1307
+ + E S LL+ + L++ LQ+ E+ + K ++S +
Sbjct: 2026 FQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEAL 2085
Query: 1308 LHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQ-KLEALHRLWDELQA 1366
N LK ++A + LE + M+ TA V Q KL + + +++L
Sbjct: 2086 ATNMKLKQ-----DIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCL 2140
Query: 1367 TTKEKTQHLSAARSSDLRLQTHADLNKWISA-----MEDQLR----SDDPGKDLTSVNRM 1417
+EK L +L A++ + +S ME++ R + P +D+T +
Sbjct: 2141 QQQEKESSLK-------KLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQ 2193
Query: 1418 LAKLK-RVEDQVNVRKEELGELFAQVPSMGEEGGDADL--------SIEKRFLDLLEPLG 1468
+ +L +EDQ +E L L V + G DL ++ K F +L + +
Sbjct: 2194 IQELNLEMEDQ----QENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVK 2249
Query: 1469 RRKKQLESSRAKLQISRDL-EDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEI 1527
R+K S + +L R L W++E + + + ++ ++ ++L ++
Sbjct: 2250 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2309
Query: 1528 LGHTPRVEDVLQRGQQL----VEAAEID------------------------CQDLEE-- 1557
VE++ +G L +E D C+DL E
Sbjct: 2310 ASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQ 2369
Query: 1558 -RLGHLQSSWDRLREAAAGRLQRLRDA-NEAQQYYLDADEAEAWIGEQELYVISDEI--- 1612
+ + +++L R + L+ N ++ + +A+ W+ +E + S +
Sbjct: 2370 CDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSS 2429
Query: 1613 PKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA--GHPEGEQIIRLQGQVDK 1670
P E + + +E I+++ GLL E E ++Q +++
Sbjct: 2430 PTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNS 2489
Query: 1671 HYAGLKDVAEERKRKLE-NMYHLFQLKRETDDLEQWISEKELVAS-SPEMGQDFDHVTLL 1728
+ +V R+R+LE + HL + L W+ EKEL+ + D + +
Sbjct: 2490 RWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ 2549
Query: 1729 RDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKD--GLNEMWADLLELI 1786
+ + + +E A Q+ A L G +T K+ +N+ W +L + +
Sbjct: 2550 KQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKL 2609
Query: 1787 DTR-MQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFER-- 1843
++R Q+ A +Y E+L + EK R + + + + ++ + V E
Sbjct: 2610 NSRSSQIDQAIVKSTQY----QELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETS 2665
Query: 1844 ----ELHLLGVQVQQFQDVATRLQTAYAGEK--AEAIQNKEQEVSAAWQALLDACAGRRT 1897
+L L +V++ Q + L + GE+ + ++ + + V+ Q L D A R
Sbjct: 2666 EIRSDLEQLDHEVKEAQTLCDEL-SVLIGEQYLKDELKKRLETVALPLQGLEDLAADRIN 2724
Query: 1898 QL-VDTADKFRFFSMARDLLSWM-ESIIRQIETQERPRDVSSVELLMKYHQGINAEIETR 1955
+L A +F M +L +W+ + +Q + + ++ ++ ++ +
Sbjct: 2725 RLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQH 2784
Query: 1956 SKNFSACLELGESLLQRQHQASEE--IREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
S ++ + GESLL E+ ++ +L ++ + +E+++K R RL+ ++ Q
Sbjct: 2785 SGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQ 2844
Score = 68.2 bits (165), Expect = 8e-11
Identities = 346/1927 (17%), Positives = 696/1927 (36%), Gaps = 306/1927 (15%)
Query: 313 DLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSR 372
+LL+W+E+ L ++ N L V+ QL+ T +E G+ + +
Sbjct: 591 ELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHT-----SVEELGSSVKEARLYEGK 645
Query: 373 MRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAA 432
M N Y GKL + + E+ R L+ L +F +A
Sbjct: 646 MSQNFHTSYAETLGKLETQYCKLKETSS--------------FRMRHLQSL-HKFVSRAT 690
Query: 433 MRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN 492
WL+E + ++ + + + A + + + ++ R+L+D A+ L EN
Sbjct: 691 AELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLEN 750
Query: 493 YHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDM--LHSI--DWMDEIK 548
+ ++ + A + ++++L Q ++ A + F D L S + D IK
Sbjct: 751 HPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK 810
Query: 549 AHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQP------ 602
S + L +EDLLQ + + V ++ + + K P
Sbjct: 811 -RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKN 869
Query: 603 -------CDPQVIQDRISHLEQCFEELSNM-----------------------------A 626
CD + I+ I ++C E ++ A
Sbjct: 870 TISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDA 929
Query: 627 AGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQI-YSSLDYGKDLTSVLILQRKHKAFEDE 685
+++EQS + W + + K I ++ L DL L++ + E
Sbjct: 930 IEMASRVEQSYQKVMALWH----QLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGE 985
Query: 686 ----LRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDL-------AAF 734
++ L AH E Q++ V ++E ++ A++ L
Sbjct: 986 CHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETV 1045
Query: 735 CKKNLQDAENF-FQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE 793
K + + +N + + + +Q + D QD A R ++H E+L+
Sbjct: 1046 AKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQD-NALRIAEQEHTQ--EDLQ 1102
Query: 794 ESRGVMEHLEQQAQGFPEEFRDS---PDVTHRLQALRELYQQVVAQADLRQQRLQEALDL 850
+ R ++ + + F + S P + L L E V + + +L+ +
Sbjct: 1103 QLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVI 1162
Query: 851 YTVFGETD----ACELWMGEKEKWLAEMEMPDT--------LEDLEVVQHRFDILDQEMK 898
+ + E+ + ++E LA++ + L D++ F +LD+E
Sbjct: 1163 VRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEE-- 1220
Query: 899 TLMTQIDGVNLAANSLVESGHPRSREVKQYQD---HLNTRWQAFQTLVSERREAVDSALR 955
I + A + R+ ++++YQ+ L RW + R+ ++S
Sbjct: 1221 -----IAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQE 1275
Query: 956 VHNYCVDCEET-SKWITDKTKVVESTKDLGRDLAGIIAIQ-RKLSGLERDVAAIQARVDA 1013
V C T KWI + T E K + + +++ Q + + L ++ Q ++D
Sbjct: 1276 VLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQ 1335
Query: 1014 LERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDD- 1072
++ SQQ + + + + +E QQ G+ + +S A Q+ D
Sbjct: 1336 CQKFSQQYSTIVKDYELQLMTYKAFVES-----QQKSPGKRRRM--LSSSDAITQEFMDL 1388
Query: 1073 ---FQAWLSITQKAVA-SEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVI 1128
+ A +++T + V D L E E+++++ Q+ ++VKE
Sbjct: 1389 RTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEE---------KQEHVEKVKEL----- 1434
Query: 1129 QGQTDPEYLLLGQRLEGLDTGW-NALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ 1187
GW + L R + ++ T ++ + +K + + + ++
Sbjct: 1435 -------------------LGWVSTLARNTQGKA-TSSETKESTDIEKAILEQQVL--SE 1472
Query: 1188 EYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKE 1247
E T + ++++ ++ + K L E + ++ +++ NK + D
Sbjct: 1473 ELTTKKEQVSEAIKTSQIFLAKHGHKLS--EKEKKQISEQLNALNKAYHD---LCDGSAN 1527
Query: 1248 KVQLIEDR--HRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEA 1305
++Q ++ + H+ + Q+ LE E L + T QD+S +
Sbjct: 1528 QLQQLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQK 1587
Query: 1306 RNLHNKWLKHQ------AFVAELASHEGWLENIDAEGKQLMDEKPQFTALVSQKLEALHR 1359
K L+ +F + EG++E Q + TAL +KL
Sbjct: 1588 NQSDLKDLQDDIQNRATSFATVVKDIEGFMEE-----NQTKLSPRELTAL-REKLHQAKE 1641
Query: 1360 LWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419
++ LQ T+ + L A + SA++ + K+L +
Sbjct: 1642 QYEALQEETRVAQKELEEAVT---------------SALQQETEKSKAAKELAENKK--- 1683
Query: 1420 KLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRA 1479
K+ + D V G+L +P M + G S+EK LD + + +
Sbjct: 1684 KIDALLDWVTSVGSSGGQLLTNLPGMEQLSG---ASLEKGALDTTDGY----MGVNQAPE 1736
Query: 1480 KLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQ 1539
KL D + E + + L+Q ++ Q+ Q F+ ++ GH E+
Sbjct: 1737 KL----DKQCEMMKARHQELLSQQQNFILATQSAQAFLDQH--------GHNLTPEE--- 1781
Query: 1540 RGQQLVEAAEIDCQDLEERLGHLQSSWD---RLREAAAGRLQRLRDANEAQQYYLDADEA 1596
QQ+ L+++LG L+ + EA ++Q L+D E Q++ D E
Sbjct: 1782 --QQM----------LQQKLGELKEQYSTSLAQSEAELKQVQTLQD--ELQKFLQDHKEF 1827
Query: 1597 EAWI--GEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSA- 1653
E+W+ E+EL + + E +LKR V + +++ + Q +L
Sbjct: 1828 ESWLERSEKELENM-HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME 1886
Query: 1654 -GHPEGEQIIRLQGQV-DKHYAGLKDVAE-------------ERKRKLENMYHLFQLKRE 1698
EG++ + V DK LKD E L YH FQ
Sbjct: 1887 NSFKEGKEPSEIGNLVKDK----LKDATERYTALHSKCTRLGSHLNMLLGQYHQFQ--NS 1940
Query: 1699 TDDLEQWISE---------KELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
D L+ W+ + VAS P + Q + + + + A + E++
Sbjct: 1941 ADSLQAWMQACEANVEKLLSDTVASDPGVLQ--EQLATTKQLQEELAEH--QVPVEKLQK 1996
Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLL----AASYDLHRYFYT 1805
V I + + + E D + + L + R LL A S + +
Sbjct: 1997 VARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLES 2056
Query: 1806 GAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTA 1865
+ +G + E++ E + L + + + ++++ ++ +++ TR
Sbjct: 2057 LLQSIGEV-EQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMET 2115
Query: 1866 YAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFS-MARDLLSWMESIIR 1924
A +Q K EVS ++ L + + L + F ++ L +ME+ R
Sbjct: 2116 ADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSR 2175
Query: 1925 QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLEL-------GESLLQRQHQ-A 1976
+ + +P + + Q +N E+E + +N L G +L QHQ
Sbjct: 2176 MLASGNQPD--QDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDR 2233
Query: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036
+ +R+ ++ KE + + E+L +F + + WL E + +
Sbjct: 2234 VQNLRKDFTELQKTVKEREKDASSCQEQLD------EFRKLVRTFQKWLKETEGSIPPTE 2287
Query: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEETGPQEEEG 2096
T S ++L K+ E + WA + +E+ + K + E T P + +G
Sbjct: 2288 ---TSMSAKELEKQIEHLKSLLDDWASKGTLVEE---INCKGTSLENLIMEITAP-DSQG 2340
Query: 2097 ETAGEAP 2103
+T P
Sbjct: 2341 KTGSILP 2347
Score = 54.3 bits (129), Expect = 1e-06
Identities = 102/497 (20%), Positives = 193/497 (38%), Gaps = 63/497 (12%)
Query: 292 KVIDHAIE-------TEKMIEKYSGLASDLLTWIEQTITVLNSR-KFANSLTGVQQQLQA 343
KV+ +IE K +++ L+ W+E + L+S + +N ++ QL
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLS- 4634
Query: 344 FSTYRTVEKPPKFQEK-GNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEA 402
K +FQ+ G + + T RA +K P D + + + L E
Sbjct: 4635 --------KHKEFQKTLGGKQPVYDTTIRTGRALKEKTLLPEDSQKLDNF------LGEV 4680
Query: 403 EYRRELALRNELIRQEKLEQ---LARRFDRKAAMRETWLSENQRLVAQDNFGY-DLAAVE 458
+ + + RQ KLE+ + +F WL + + +A+D + DL V
Sbjct: 4681 RDKWDTVCGKSVERQHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVM 4740
Query: 459 AAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQ 518
H+ + + V+ L+ +EL + + D + + + W + +L
Sbjct: 4741 NLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSV 4800
Query: 519 SRRQRLETTLALQKLFQDMLHS-IDWMDEIKAHL-LSAEFGKHLLEVEDLLQKHKLMEAD 576
S++ RLE L ++F+D +H ++W+ E + L ++ L+ HK E
Sbjct: 4801 SKQSRLEQALKQAEVFRDTVHMLLEWLSEAEQTLRFRGALPDDTEALQSLIDTHK--EFM 4858
Query: 577 IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQS 636
++ +V +A + P I+ I+ + FEE+ A + +LE +
Sbjct: 4859 KKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKHWITIIRARFEEVLTWAKQHQQRLETA 4918
Query: 637 -KRLWKFFWEMDEAESWIKEKEQIYSSLD---YGKDLTSVLILQRKHKAFEDELRGLDAH 692
L ++E +WI+ E D +++ V L +H+ F +E+
Sbjct: 4919 LSELVANAELLEELLAWIQWAETTLIQRDQEPIPQNIDRVKALIAEHQTFMEEMTRKQPD 4978
Query: 693 LEQI---------------FQEAHGMVARKQFGHP---------QIEA---RIKEVSAQW 725
++++ F E RK P Q EA RI ++SA+W
Sbjct: 4979 VDRVTKTYKRKNIEPTHAPFIEKSRSGGRKSLSQPTPPPMPILSQSEAKNPRINQLSARW 5038
Query: 726 DQLKDLAAFCKKNLQDA 742
Q+ LA ++ L DA
Sbjct: 5039 QQVWLLALERQRKLNDA 5055
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 298 bits (763), Expect = 4e-80
Identities = 172/388 (44%), Positives = 234/388 (60%), Gaps = 15/388 (3%)
Query: 48 LADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGK 107
+ADER+ VQKKTFTKW+N HL +V + DLY+DLRDG LI LLEVLSG+ LP+ KG+
Sbjct: 58 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 116
Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ 167
MR H L+NV AL +LK ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V +
Sbjct: 117 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 176
Query: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKD 227
E SAK+ LLLW Q T GY + NFT+ W+DG FNA+IHK+RPDLID + +
Sbjct: 177 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 234
Query: 228 SNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEG 287
+ NLEHAF VAE+ +G+I LLDPEDV +PDEKS+ITYV + Y F K + G
Sbjct: 235 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK---VPEGG 290
Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTY 347
+ +G A + E +Y + + L+ WI +T ++ R F N+ ++ + +
Sbjct: 291 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 345
Query: 348 RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRE 407
+ E PPK EK ++ L ++ + K+ G +DI + W L A RE
Sbjct: 346 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 402
Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRE 435
ALR E+ R E L+Q+A R R + + E
Sbjct: 403 KALRPEVERLEMLQQIANRVQRDSVICE 430
Score = 171 bits (432), Expect = 9e-42
Identities = 321/1659 (19%), Positives = 676/1659 (40%), Gaps = 141/1659 (8%)
Query: 387 KLVSDINRAWESL-EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRL 444
K +S ++ WE+L +AE R + E + +A++F WL+ +RL
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNR--------QLEGISVVAQQFHETLEPLNEWLTTIEKRL 3467
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
V + G + +E +H+A+E D + + + + Q L+ + + K + K
Sbjct: 3468 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3527
Query: 505 NILRLWSY-LQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEIKAHLLSAEFGKHLLE 562
+ ++W +QE SR + L+ L K+F +D + ++W++E+ L + E
Sbjct: 3528 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3587
Query: 563 VEDLLQKH-KLMEADIAIQGDKVKAITA---ATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
Q ++++ DI ++ V LK T G + +IQD++ ++
Sbjct: 3588 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGD-----EVLIIQDKLEAIKAR 3642
Query: 619 FEELSNMAAGRKAQLEQSKRLWKFFWEM-DEAESWIKEKEQIYSSLDY----GKDLTSVL 673
+++++ ++ LEQ+ +L + +E +W+ + E S + G++ +
Sbjct: 3643 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA- 3701
Query: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQLKDLA 732
Q + K + E + A L+ + + + ++ + +E + E + ++ + D
Sbjct: 3702 --QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3759
Query: 733 AFCKKNLQDAE-NFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKHKDFLE 790
+ + A QF AD +W+ + + L+S D+ ++ T A + K F
Sbjct: 3760 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3819
Query: 791 ELEESRGVMEHLEQQAQGF----PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
E+ + +++ L + EE + S + +L + + Y + R +L+
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLER 3877
Query: 847 ALDLYTVFGET-DACELWMGEKEKWLAEMEMPDT-LEDLEVVQHRFDILDQEMKTLMTQI 904
A L F ET + W+ E + ++++ P E L Q L + + I
Sbjct: 3878 AQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3937
Query: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
D +N L+E +++ +T + + V +R A+D A+ D
Sbjct: 3938 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD-- 3995
Query: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLS---GLERDVAAIQARVDALERESQQL 1021
+ + + ++VE + A + I+ ++S + D+ +Q + L++ +++
Sbjct: 3996 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055
Query: 1022 MDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-QAFLQDLDDFQA 1075
+ +DI + Q L+++ W+ + ++ +E L +V +L + F D
Sbjct: 4056 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4115
Query: 1076 WLSITQKAVASEDMPESLPEAEQLLQQHAG-IKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134
+ TQ + + P P + Q+ A I++EIDG Q+ V G ++I +P
Sbjct: 4116 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4175
Query: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAE-AILSNQEYTLAH 1193
+ ++ + ++ L++ W++L + W+ R L + + +D QA + LA
Sbjct: 4176 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLAS 4235
Query: 1194 LEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-------- 1244
+ P LE + I + + F + ++ L+ + SDK
Sbjct: 4236 MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLM 4295
Query: 1245 -IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI--NDKLLTSQDVS 1301
+K +E+R K + A L L F EL W+ + LL+ Q
Sbjct: 4296 ELKLIWDSLEERIINRQHKLEGAL------LALGQFQHALDELLAWLTHTEGLLSEQKPV 4349
Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP-QFTALVSQKLEALHRL 1360
+ + + + KH ++ +H+ +E ++ G L++ + + + KLE L++
Sbjct: 4350 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4409
Query: 1361 WDELQATTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDP-------GKDLT 1412
W + T+++ Q L A R + DL +W++ E L + P K+
Sbjct: 4410 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4469
Query: 1413 SVN-RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL-SIEKRFLDLLEPLGRR 1470
+V+ + A + E+ ++ ++ A+ P E D D+ ++++++ + L R
Sbjct: 4470 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4529
Query: 1471 KKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
K +LE + ++ L+D W+ E+ L +A L TV + +++ NE
Sbjct: 4530 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP--SLILDTVLFQIDEHKVFANE 4587
Query: 1527 ILGHTPRVEDVLQRGQQL-VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE 1585
+ H ++ ++ + G L + + D ++ L +QS W+++ + R + L DA +
Sbjct: 4588 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4647
Query: 1586 -AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQRAV---------- 1633
A+Q++ + W+ E E + S+ EI D + L +H Q+++
Sbjct: 4648 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4707
Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693
GR++K+ S A L + + L+ + D + + ER+ KLE L
Sbjct: 4708 NRTGRSLKEKTSLADDNLKL----DDMLSELRDKWDT----ICGKSVERQNKLEEA--LL 4757
Query: 1694 QLKRETDDLEQWIS-----EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVD 1748
+ TD L+ I E +L P G D D V L D + F +E G +R
Sbjct: 4758 FSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELG----KRTS 4812
Query: 1749 NVNAF---IERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY----DLHR 1801
+V A LI+ +++ + L+ W + L ++ L A+ + H
Sbjct: 4813 SVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHS 4872
Query: 1802 YFYTGAEILGLIDEK---HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
+ E L ++ H LP+ D + H F ++L ++ + +
Sbjct: 4873 VVHALLEWLAEAEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4928
Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA-----DKFRFFSMAR 1913
+ + I++ + A ++ +L A A + Q + +A K
Sbjct: 4929 GDTVLAICHPDSITTIKHWITIIRARFEEVL-AWAKQHQQRLASALAGLIAKQELLEALL 4987
Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
L W E+ + + + P+++ V+ L+ HQ E+
Sbjct: 4988 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026
Score = 157 bits (397), Expect = 1e-37
Identities = 322/1813 (17%), Positives = 717/1813 (39%), Gaps = 209/1813 (11%)
Query: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
++ I W++ + RE L+ L + A ++ + W+ + Q + +
Sbjct: 2872 LNTIKTNWDTFNKQVKERENKLKESL-------EKALKYKEQVETLWPWIDKCQNNLEEI 2924
Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
F D A E + K ++++ + + V L + A L D++ +T ++++
Sbjct: 2925 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2984
Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQDML-----------HSIDWMDEIKAHLLSAEFG 557
+ E L S++ LE K FQ++ +D D + + S ++
Sbjct: 2985 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3044
Query: 558 KHLLEVEDLLQ--KH-----KLMEADIAIQGDKVKAITAATLKF-TEGKGYQPCDPQV-- 607
L + LQ KH K + D+ ++ K + L+ T + + QV
Sbjct: 3045 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3104
Query: 608 ------------------IQDRISHLEQCFEELSNMA-AGRKAQLEQSKRLWKFFWEMDE 648
I++ S + +EL +MA GR A+ Q ++ +
Sbjct: 3105 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQK--------ET 3156
Query: 649 AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
++++K+ E + +S D +++ + +L G+ LE + ++ + ++ R Q
Sbjct: 3157 IKAFLKKLEALMASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDRAQ 3213
Query: 709 FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
Q+E IK + + +LK+ + LQ AE + QG +
Sbjct: 3214 AREEQVEGTIKRLEEFYSKLKEFSIL----LQKAEEHEESQGPVG------------MET 3257
Query: 769 EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD---VTHRLQA 825
E + Q + K EE+E +G + + QG + S + H L
Sbjct: 3258 ETINQQLNMFKVFQK------EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3311
Query: 826 LRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLE 884
+ ++ + + R +LQEAL F + ++ WM + E+ +A + P + +
Sbjct: 3312 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA--EFK 3369
Query: 885 VVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EVKQYQDHLNTRWQAFQ 940
VV+ + +L + + + ++ + + + P + ++ + L++RW+A
Sbjct: 3370 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3429
Query: 941 TLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
R ++ ++ + E ++W+T K + + + +G + + +
Sbjct: 3430 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKA 3489
Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ-GLQQSLQGQEDLLG 1058
LE D+ + Q L + +D+ Q + ++W +Q+ + +LL
Sbjct: 3490 LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQ 3549
Query: 1059 E-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI-KDEIDGHQDS 1116
+ + + F +D + WL+ ++ + + E Q + +++I + +
Sbjct: 3550 QALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQN 3609
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ---------- 1166
+ +G ++++ T E L++ +LE + + + ++ + TL Q
Sbjct: 3610 VDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHS 3669
Query: 1167 -----CLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
C + + + E +L +E + A + P + + A + + L S+
Sbjct: 3670 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA----KNNKALLDSLNEV 3725
Query: 1221 RDKVLSPV-----DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
+L V + K+VAE N L SD I +KV+ I+ + +LR
Sbjct: 3726 SSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-------------AAILR 3772
Query: 1272 DNLELQNFLQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
Q F Q WI + KL++ D+ ++ + ++ + F E+ H+
Sbjct: 3773 S----QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQ-KTFTMEILRHKDI 3827
Query: 1329 LENIDAEGKQLM----DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
++++ G ++M +E+ Q + +KL+ + + +D + E+ L A+S +
Sbjct: 3828 IDDLVKSGHKIMTACSEEEKQ---SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3884
Query: 1385 L-QTHADLNKWISAMEDQL-RSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV 1442
+T+ +L W++ + + + P + ++ + + +++ + + K + ++
Sbjct: 3885 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3944
Query: 1443 PSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
P + E SI+++++ + E + +R L+ + ++ D D+ L
Sbjct: 3945 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4004
Query: 1496 ERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA----- 1548
ER+ L Q ++ ++ + +N+ + ++ P E + QRG++++ +
Sbjct: 4005 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4064
Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYV 1607
+I + ++++L + W+ + R +L D E A++++ D I + + ++
Sbjct: 4065 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4124
Query: 1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR--------AQGLLSAGHPEGE 1659
E P + + +QQ A E I L ++ + + G P+
Sbjct: 4125 RDLEDPGIDPSVV------KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4178
Query: 1660 QIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQW--ISEKELVASSP 1716
+ + +++ + L ++R KLE M Q + + W I+ +L + SP
Sbjct: 4179 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4238
Query: 1717 EMGQDFDHVTLLRDKFRDFARET--GAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDG 1774
+G D + V ++ + F E I ER+++ + + + S+ T+ +
Sbjct: 4239 -IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV-TEESDKHTVQDPLME 4296
Query: 1775 LNEMWADLLE-LIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPED--VGLDASTA 1831
L +W L E +I+ + +L A L ++ + E+L + L E VG D
Sbjct: 4297 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356
Query: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
E H + ++ V+ L + AGE+A +QNK + ++ WQ +L+
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4416
Query: 1892 CAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYHQGIN 1949
R+ QL + + F DL W+ R + + + + + + H +
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4476
Query: 1950 AEIETRSKNFSACLELGESLLQRQHQASE--------EIREKLQQVMSRRKEMNEKWEAR 2001
A E + + + + ++ G+ +L R +++E ++EK + V ++ E K E
Sbjct: 4477 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE-- 4534
Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYL-ASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
E L + +E F WL E L + +D+V I H+ F S
Sbjct: 4535 -EALNLAME---FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4590
Query: 2061 WAERFAALEKPTT 2073
E+ L+K T
Sbjct: 4591 HREQIIELDKTGT 4603
Score = 155 bits (393), Expect = 3e-37
Identities = 308/1553 (19%), Positives = 632/1553 (40%), Gaps = 124/1553 (7%)
Query: 606 QVIQDRISHLEQCFEELSNMAAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLD 664
Q ++ + + ++ L+ A R AQL+++ +F ++ SW+ + E++ ++
Sbjct: 3303 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3362
Query: 665 YGKDLTSVLILQ-RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHP-QIEARIKEVS 722
V+ Q ++ K + L + +E I +E + + +I ++ +
Sbjct: 3363 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3422
Query: 723 AQWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAH-RLLSGEDVGQDEGATRA 780
++W+ L + A + L+ Q F + L WL RL++ E +G
Sbjct: 3423 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3482
Query: 781 LGKKHKDFLEELEESRGVMEHLEQ-----QAQGFPEEFRDSPDVTHRLQALRELYQQVVA 835
+HK +++ +HL Q Q+ D V +L + Y ++
Sbjct: 3483 QIAQHKALEDDIINHN---KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3539
Query: 836 QADLRQQRLQEALDLYTVFGETDACEL--WMGEKEKWLAEMEMPD-TLEDLEVVQHRFDI 892
++ R + LQ+AL +FGE D EL W+ E L+++ + D + E L Q +
Sbjct: 3540 KSHSRSELLQQALCNAKIFGE-DEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3598
Query: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNT---RWQAFQTLVSERREA 949
L +++ +D L L++ EV QD L R++ L ++ +
Sbjct: 3599 LQEDILLRKQNVDQALLNGLELLKQ--TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3656
Query: 950 VDSAL----RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKL--SGLERD 1003
++ AL R+H+ EE W+ DK +V E + L G A Q ++ L+++
Sbjct: 3657 LEQALQLARRLHS---THEELCTWL-DKVEV-ELLSYETQVLKGEEASQAQMRPKELKKE 3711
Query: 1004 VAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQSL-QGQEDLLGEVS 1061
+A +D+L S L++ P +E + + E ++ + ++ Q E++ +
Sbjct: 3712 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3771
Query: 1062 QLQAFLQDLDDFQAWLSITQKAVAS-EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRV 1120
+ Q F Q D +W++ T+K + S D+ + LQ EI H+D +
Sbjct: 3772 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3831
Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGF-QEFQKDAKQ 1179
+SG K++ ++ E + ++L+ + ++ + ++ R L + +F + ++
Sbjct: 3832 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3891
Query: 1180 AEAILSNQEYTLAHLEPP----DSLEAAEAGIRKFEDFLGSMENNRDKV---------LS 1226
L+ + ++ L P ++L + R+ + + + + DK+ LS
Sbjct: 3892 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3951
Query: 1227 PVDSGN---KLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNC 1283
P + + K VA LYS +IKE V+ ++A + + + + +
Sbjct: 3952 PGEGFSIQEKYVAADTLYS-QIKEDVK----------KRAVALDEAISQSTQFHDKIDQI 4000
Query: 1284 QELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM--- 1340
E I ++L +S E + + +++ ++ + E + G++++
Sbjct: 4001 LESLERIVERLRQPPSISA-EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4059
Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEK-TQHLSAARSSDLRLQTHADLNKWISA 1397
+K V KL+ + +W+ + +E+ + L ++ H L I
Sbjct: 4060 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4119
Query: 1398 MEDQLRS-DDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSI 1456
+D +R +DPG D + V + + + ++++ +EEL + + G+ D I
Sbjct: 4120 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4179
Query: 1457 EKRFLDLLEPL---------GRRKKQLESSRAKLQISRDLEDETLWVE-ERLPLAQSADY 1506
K+ +D L R K E+ +A +Q L+ WV+ LA +
Sbjct: 4180 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4239
Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQS 1564
GT+L+TV+ +++ + ++E +E + + + L++ E D +++ L L+
Sbjct: 4240 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299
Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAEAWIGEQELYVISDEIPK--DEEGAIV 1621
WD L E R +L A A + A DE AW+ E ++S++ P D + +
Sbjct: 4300 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE-GLLSEQKPVGGDPKAIEI 4358
Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDV 1678
L +H Q V + ++ + L+ + GE+ LQ +++ + + + +
Sbjct: 4359 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS--AGEEASNLQNKLEVLNQRWQNVLEK 4416
Query: 1679 AEERKRKLENMYHLFQ-LKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDF 1735
E+RK++L+ + E +DL+QW++ E+ L+AS P G L +
Sbjct: 4417 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL-----NV 4471
Query: 1736 ARETGAIGQERVDNVNAFIER----LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
E A + + + + +++ L S I + + L E W + ++ R
Sbjct: 4472 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4531
Query: 1792 LLAASYDLHRYFYTGAE-ILGLIDEKHREL--PEDVGLDASTAESFHRVHTAFERELHLL 1848
L + +L F+ + + + + + L L T H F E++
Sbjct: 4532 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4591
Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
Q+ + T L+ + I+N V + W+ ++ R L D + +
Sbjct: 4592 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4651
Query: 1909 FSMA-RDLLSWMESIIRQIETQ-ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELG 1966
F A L+ W+E + ++++ E D ++ + H+ + + + G
Sbjct: 4652 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4711
Query: 1967 ESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAE 2022
SL ++ A + + KL ++S E+ +KW+ ER L E FS + A
Sbjct: 4712 RSLKEKTSLADDNL--KLDDMLS---ELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4766
Query: 2023 A----WLIAQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
WL EP LA H +D V LI H+AF+K AL++
Sbjct: 4767 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819
Score = 149 bits (375), Expect = 4e-35
Identities = 358/1838 (19%), Positives = 731/1838 (39%), Gaps = 212/1838 (11%)
Query: 359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE 418
K EVLL S + A N T D +V +S+ E + ++ L L Q+
Sbjct: 2050 KKTAEVLLDARGSLLPAKNDIQKTLDD--IVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2107
Query: 419 KLEQLARRFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEER 477
L+++ W+ L Q + A++ K+ +E D A +
Sbjct: 2108 GLDEML-----------DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2156
Query: 478 VRALEDLAQE-LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
+ A+ + ++ +E + + A+ ++ +S + ++E +LF++
Sbjct: 2157 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2216
Query: 537 MLHSIDWMDEIKAHLLSAEF--GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
+ + E K L+ GK + E+ +Q+ ++ K + + LK
Sbjct: 2217 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQE----STSEFLEHKKHLEVLHSLLKE 2272
Query: 595 TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKFFWEMDEAESWI 653
G P D ++ ++ ++L + F+E+ + +K + ++L F + +SWI
Sbjct: 2273 ISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWI 2331
Query: 654 KEK-------EQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------LEQIFQE 699
KE + + + D GK L LQ K E++ ++ + +
Sbjct: 2332 KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP 2391
Query: 700 AHGMVARKQFGH--------------------PQIEARIKEVSAQWDQL----KDLAAFC 735
A + A K G I+ + ++S ++ L KD A
Sbjct: 2392 AKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAEL 2451
Query: 736 KKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEGATRALGKKHKDFLEEL 792
L + + Q ++ + WLQ ++ + D A + +++K F EL
Sbjct: 2452 NTKLSKLQ---KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2508
Query: 793 EESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALD 849
+++ ++ L+ + EE D+P+ Q L E+ +Q++ RQQ+L+E+ +
Sbjct: 2509 KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSN 2568
Query: 850 LYTVFGETDA-CELWMGEKEKWLAEMEMPDTLED--LEVVQHRFDILDQEMKTLMTQIDG 906
T F +A + W+ EKE ++ + P +++ L + + IL QE T Q +
Sbjct: 2569 NLTQFQTVEAQLKQWLVEKELMVSVLG-PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2627
Query: 907 VNLAANSLVES-GHPRSRE--VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDC 963
+ A ++ G S VK+ + +W + +S+R + +D A+
Sbjct: 2628 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAI--------- 2678
Query: 964 EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
+++++ + + + DL L+ +A+ + + + Q +++E +Q+
Sbjct: 2679 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2738
Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQG--------QEDLLGEVSQLQA-------FLQ 1068
+ ED+ K E L L + L+G ++ V LQ+ F Q
Sbjct: 2739 AQA-LCEDLSALVKE-EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2796
Query: 1069 DLDDFQAWLSITQKAVASEDMPES--LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEK 1126
DFQAWL T+K ++ P S L E L++ H + Y++ GE
Sbjct: 2797 MSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN 2855
Query: 1127 VIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI--- 1183
++ E L +L + T W+ + + R + L + L ++ K +Q E +
Sbjct: 2856 LLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL--EKALKYKEQVETLWPW 2913
Query: 1184 -------LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NNRDKVLSPVDSGNK 1233
L ++ L E +S+ ++ ++ + G +E N + +LS + +
Sbjct: 2914 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 2973
Query: 1234 LVAEGNLYSDKIKEKVQLI-EDRHRKN---NEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
+V + N + +KV ++ E H K Q+ + E + LQ C + L
Sbjct: 2974 VVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ-CAKEQLD 3029
Query: 1290 INDKL----LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ 1345
I+D L +++ ++ + + + LKHQ +A+ + + +E D++G
Sbjct: 3030 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--------- 3080
Query: 1346 FTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS 1404
T+ V ++E + + L EK L Q T ++ + +D+L S
Sbjct: 3081 -TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDS 3139
Query: 1405 DDP-GKDLTSVNR----MLAKLKRVE----DQVNVRKEELGELFAQVPSMGEEGGDADL- 1454
P G+D ++ + + A LK++E N K L + S G DL
Sbjct: 3140 MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLE 3199
Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKLQ--ISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
++ K+ LL+ R++Q+E + +L+ S+ E L + G +T
Sbjct: 3200 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3259
Query: 1513 VQLFMKKNQTLQ-NEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRL 1569
+ + + Q EI + +DV GQ L+++A Q LE L + + W L
Sbjct: 3260 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3319
Query: 1570 REAAAGRLQRLRDANEAQQYYLDADEA-EAWIGEQELYVISDEIPKDEEGAI-VMLKRHL 1627
+ A R +L++A + DA E+ +W+ + E V + + P E + ++
Sbjct: 3320 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3379
Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGE-QIIRLQGQVDKHYAGLKDVAEERKRKL 1686
QR ++D ++ + + + + P + +I++ +D + L + AE R R+L
Sbjct: 3380 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3439
Query: 1687 ENMYHLFQLKRET-DDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
E + + Q ET + L +W++ EK LV P + K + + A+
Sbjct: 3440 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP--------IGTQASKLEEQIAQHKAL- 3490
Query: 1744 QERVDNVNAFIERLIDAGHS-------EAATIAEWKDGLNEMW-ADLLELIDTRMQLLAA 1795
++ + N N + + + G S E + + K +++W ++ E +R +LL
Sbjct: 3491 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3550
Query: 1796 SYDLHRYF-YTGAEILGLIDEKHRELPEDVGLDASTAESFHRVH--TAFERELHLLGVQV 1852
+ + F E++ ++E H +L + D ST + + + ++ L V
Sbjct: 3551 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3610
Query: 1853 QQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-----R 1907
Q L G++ IQ+K + + A ++ + T + T ++ R
Sbjct: 3611 DQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL----STDVAKTLEQALQLARR 3666
Query: 1908 FFSMARDLLSWMESI---IRQIETQE-RPRDVSSVELLMKYHQGINAEIETRSKNFSACL 1963
S +L +W++ + + ETQ + + S ++ K E++ +KN A L
Sbjct: 3667 LHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-------ELKKEAKNNKALL 3719
Query: 1964 ----ELGESLLQR-QHQASEEIREKLQQVMSRRKEMNEKWEARWERL-RMLLEVCQFSRD 2017
E+ +LL+ +A E + + + + R + +++ + E + +L QF +
Sbjct: 3720 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3779
Query: 2018 ASVAEAWLIAQEPYLAS-GDFGHTVDSVEKLIKRHEAF 2054
A +W+ E L S GD D ++ + F
Sbjct: 3780 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3817
Score = 129 bits (325), Expect = 2e-29
Identities = 389/2030 (19%), Positives = 780/2030 (38%), Gaps = 278/2030 (13%)
Query: 277 FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSG--LASDLLTWIEQTITVLNSRK---FA 331
FSK K+ + E + + A++T ++ G + + +E+ + L F+
Sbjct: 1500 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1559
Query: 332 NSLTGVQQQLQAFSTYRTV--------EKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTP 383
SL +QLQ T V E+ +++EK L T +Q+ +
Sbjct: 1560 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1615
Query: 384 HDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
DG + E ++ + + EL Q+ ++ A+ E +L EN
Sbjct: 1616 GDGTV--------------ELKKYQSKQEEL--QKDMQGSAQALAEVVKNTENFLKENGE 1659
Query: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
++Q++ + AK K E + ++ + + A + E E K++ K
Sbjct: 1660 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1719
Query: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH--------SIDWMDEIKAHLLSAE 555
I L +L + + T Q + Q+ H +I DE+ +LL +
Sbjct: 1720 TKIENLLDWLSNV--DKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1777
Query: 556 FGKHLLEVEDLL----QKHKLMEADIAIQGDKVKAIT--AATLKFTEGKGYQPCDPQVIQ 609
+ ++ L QK K I Q V T A L +G+ P + + +Q
Sbjct: 1778 VDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ 1837
Query: 610 DRISHLEQCFEE-LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYG-K 667
+ L+ +E L+ K + L KF + E E W+++ EQ +L+ G
Sbjct: 1838 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897
Query: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQI------FQEAHGMVARKQFGHPQIEARIKEV 721
D+ ++ ++ K+F +++ L I EA +++ G A +EV
Sbjct: 1898 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1957
Query: 722 SAQWDQLKD----LAAFCK---KNLQDAENFFQFQGDAD-DLKAWLQDAHRLLS---GED 770
+ D D L + C NL+D + +Q DA L A LQ S E
Sbjct: 1958 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2017
Query: 771 VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE----FRDSPDVTHRLQAL 826
+ D + ++ K ++ + +E L++ A+ + D+ L +
Sbjct: 2018 IAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI 2077
Query: 827 RELYQQVVAQADLRQQRLQEALD-LYTVFGETDACELWMGEKEKWLAEM-EMPDTLEDLE 884
Y+ + + R ++LQ L +V D WMG E L E ++P L+
Sbjct: 2078 VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ 2137
Query: 885 VVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP----------------------RS 922
+ + +L+Q++ + I+ +N +E+ P +
Sbjct: 2138 DIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKH 2197
Query: 923 REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV-ESTK 981
+E + L T+ + F+ L + + +++ + + + K +T+ ++ + EST
Sbjct: 2198 KETLAKMEELKTKVELFENLSEKLQTFLETKTQA---LTEVDVPGKDVTELSQYMQESTS 2254
Query: 982 DL---GRDLAGIIAIQRKLS--GLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ 1036
+ + L + ++ +++S GL D A + + + L ++ +++ D+ E+KE + Q
Sbjct: 2255 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQ 2314
Query: 1037 KHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
+ L + +Q L +SL+ + + + I Q + +ED+ +SL +
Sbjct: 2315 EQL-DAFQVLVKSLKSW----------------IKETTKKVPIVQPSFGAEDLGKSLEDT 2357
Query: 1097 EQLLQQHAGIKDEIDGHQDS----------------YQRVKESGEKVIQGQ---TDPEYL 1137
++L ++ + EI +S +SG V+ G+ T+ E
Sbjct: 2358 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2417
Query: 1138 LLGQRLEG-------LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS----- 1185
+ L + G+ LG + + + L L + QK +++ A++
Sbjct: 2418 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL--SKLQKAQEESSAMMQWLQKM 2475
Query: 1186 NQEYTLAHLEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEG--NLYS 1242
N+ T P P EA + + + + F ++ N +KV D +L+ E +
Sbjct: 2476 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2535
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQ--- 1298
+ K+ + I+ + ++ N+ + L ++ L F +L W+ +K L
Sbjct: 2536 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2595
Query: 1299 DVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD---EKPQFTALVSQKLE 1355
+S D L+ + + Q + E A+ + E + A G+ ++ E P +V ++L
Sbjct: 2596 PLSID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2654
Query: 1356 ALHRLWDELQATTKEK-----------TQHLSAARSSDLRLQTHADL-NKWISAMEDQLR 1403
A+ + WD L ++ TQ+ S RS +L +DL NK S++
Sbjct: 2655 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL---SDLDNKLSSSLAVSTH 2711
Query: 1404 SDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLS-----IEK 1458
D + L + +M ++++ + Q+ V + +L A V EE A+LS I K
Sbjct: 2712 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK---EEYLKAELSRQLEGILK 2768
Query: 1459 RFLDLLEPLGRRKKQLESSRAK----LQISRDLEDETLWVE-ERLPLAQSADYGTNLQTV 1513
F D+ + + L+S+ A Q+SRD + W++ ++ +S L +
Sbjct: 2769 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVL 2825
Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQ-LVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
+ +K ++ + + E + G+ L++ + L+ +L ++++WD +
Sbjct: 2826 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2885
Query: 1573 AAGRLQRLRDANE-AQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRH 1626
R +L+++ E A +Y + WI + +E+ D P + E +I LK
Sbjct: 2886 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLK-- 2941
Query: 1627 LRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKL 1686
Q+ ++ + ++ L + A LLS + E + + + + + +K L
Sbjct: 2942 -SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3000
Query: 1687 ENMYHLFQLKRET--DDLEQWISEKELVASSPEMGQDF---DHVTLLRDKFRDFARETGA 1741
ENM F+ +E + Q KE + +G ++T+L+ + +
Sbjct: 3001 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3060
Query: 1742 IGQERVDNVNAFIERLIDAGHS----EAATIAEWKDGLNEMWADLLELIDTRMQLLAASY 1797
+ + + +E G S + TIA+ L++ + ++T++Q +
Sbjct: 3061 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3120
Query: 1798 DLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELH-LLGVQVQQFQ 1856
+ R + ++ DE P VG DA T + AF ++L L+ +
Sbjct: 3121 NTIREMF--SQFAEFDDELDSMAP--VGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3176
Query: 1857 DVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMARDL 1915
L T I+ + +S LLD R Q+ T + F+S ++
Sbjct: 3177 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3236
Query: 1916 LSWMESIIRQIETQ----ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
++ E+Q ++ + K Q EIE LG+ L+Q
Sbjct: 3237 SILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQ 3294
Query: 1972 --RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQE 2029
+ +++ + L V +R K +N+K R +L+ L C
Sbjct: 3295 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC----------------- 3337
Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASW---AERFAALEKPTTLELK-------ER 2079
G D++E L+ SW E A +KP + E K E+
Sbjct: 3338 --------GRFQDALESLL-----------SWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3378
Query: 2080 QIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESL 2129
++ +R ++ E + GE + ++ + S L S WE+L
Sbjct: 3379 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3428
Score = 102 bits (254), Expect = 4e-21
Identities = 315/1749 (18%), Positives = 686/1749 (39%), Gaps = 177/1749 (10%)
Query: 387 KLVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRFDRKAAMRETWLSENQRLV 445
K ++DI+ +E L L L++++ KL +L + + +AM + WL + +
Sbjct: 2428 KDMTDISHGYEDLG-------LLLKDKIAELNTKLSKLQKAQEESSAMMQ-WLQKMNKTA 2479
Query: 446 A---QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN--YHDQKRIT 500
Q D AV+ +++++ E + +V+ L+D EL +EN + R
Sbjct: 2480 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2539
Query: 501 ARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFGKH 559
I W L +L R+Q+LE + FQ + + W+ ++ L+ + G
Sbjct: 2540 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPL 2597
Query: 560 LLEVEDL---LQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
++ L Q+ +++ + A + + + +TAA G P +++++++ +
Sbjct: 2598 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2657
Query: 617 QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
Q ++ L+ + R ++Q+ + + +S ++ S LD L+S L +
Sbjct: 2658 QKWDSLTGQLSDRCDWIDQA------IVKSTQYQSLLRSLSDKLSDLD--NKLSSSLAVS 2709
Query: 677 RKHKAFEDELRGLDAHLEQIFQEAH------------GMVARKQFGHPQIEARIKEVSAQ 724
A +L ++I QE + ++++ ++ +++ +
Sbjct: 2710 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2769
Query: 725 WDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQ-DAHRLLSGEDVGQDEGATRALG 782
+ ++ A ++LQ A + QFQ + D +AWL + +L
Sbjct: 2770 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLI 2829
Query: 783 KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ--ALRELYQQVVAQADLR 840
K HKDF + L + E + + + + S +LQ ++ + Q R
Sbjct: 2830 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2889
Query: 841 QQRLQEALDLYTVFGE-TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKT 899
+ +L+E+L+ + E + W+ + + L E++ + E + L +EM
Sbjct: 2890 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2949
Query: 900 LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNY 959
++ +N ANSL+ V L + + ++ +++ +
Sbjct: 2950 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK- 3008
Query: 960 CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK----LSGLERDVAAIQARVDALE 1015
+ +E SK + + + D+ D G A K L ++ + A++ +VD +
Sbjct: 3009 --EFQEVSKESKRQLQCAKEQLDI-HDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3065
Query: 1016 RESQQLMDSHPEQK--EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDF 1073
R +Q L+ + K D+ + + + + L Q + + S L+ LQ + F
Sbjct: 3066 RLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD------EKCSFLETKLQGIGHF 3119
Query: 1074 QAWL--SITQKAVASEDMPESLP---EAEQLLQQHAGIK---DEIDGHQDSYQRVKESGE 1125
Q + +Q A +++ P +AE L +Q IK +++ S ++ +
Sbjct: 3120 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3179
Query: 1126 KVI-QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCL-GFQEFQKDAKQAEAI 1183
++ +T P+ + + + LE L N L ++R + + +EF K+ +
Sbjct: 3180 MMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSIL 3239
Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
L E H E + I + + + + L + +G + S
Sbjct: 3240 LQKAE---EHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA 3296
Query: 1244 KIKEKVQLIED-------RHRKNNEK-AQEASVLLRDNLELQNFLQNCQELTLWIND--K 1293
Q +E R + N+K AQ A+ L L F + L W+ D +
Sbjct: 3297 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3356
Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL-MDEKPQFTALVSQ 1352
L+ +Q E + + + + + L + +E I EG+++ +P + +
Sbjct: 3357 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3416
Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTH---ADLNKWISAMEDQLRSDDP-G 1408
+L L W+ L K +T++ S + Q H LN+W++ +E +L + +P G
Sbjct: 3417 QLSLLDSRWEAL--LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3474
Query: 1409 KDLTSVNRMLAKLKRVEDQVNVRKEELGEL--FAQVPSMGEEGGDADLSIEKR------F 1460
+ + +A+ K +ED + + L + Q + D D+ K +
Sbjct: 3475 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3534
Query: 1461 LDLLEPLGRRKKQLESSRAKLQISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLF 1516
+++ E R + L+ + +I + E E + W V ++L DY T Q
Sbjct: 3535 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ-- 3592
Query: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEID-CQDLEERLGHLQSSWDRLREAAAG 1575
+ + LQ +IL V+ L G +L++ D ++++L +++ + + + +
Sbjct: 3593 QSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3652
Query: 1576 RLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISDE--IPKDEEGAIVM-----LKRHL 1627
+ L A + A++ + +E W+ + E+ ++S E + K EE + LK+
Sbjct: 3653 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3712
Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
+ +A+ D ++ +++S L+ EG + ++ + ++ Y + D ++ +++
Sbjct: 3713 KNNKALLD---SLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEID 3767
Query: 1688 NMYHLFQLKRETDDLE-QWISEKE-LVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQE 1745
Q + D E WI+E E + S ++ + D + + F E
Sbjct: 3768 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME------- 3820
Query: 1746 RVDNVNAFIERLIDAGHS-EAATIAEWKDGLNEMWADLLELIDT--------RMQLLAAS 1796
+ I+ L+ +GH A E K + + +L+ DT +QL A
Sbjct: 3821 -ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3879
Query: 1797 YDLHRYFYTGAEILGLIDEKH---RELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
+++++ T E+ + E +LP L+ T H + +
Sbjct: 3880 SLVNQFWETYEELWPWLTETQSIISQLPAP-ALEYETLRQQQEEHRQLRELIAEHKPHID 3938
Query: 1854 QFQDVATRLQTAYAGE---------KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD 1904
+ +L GE A+ + ++ +E LD + TQ D D
Sbjct: 3939 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 3998
Query: 1905 KFRFFSMARDLLSWMESIIRQIETQERPRDVSS----VELLMKYHQGINAEIETRSKNFS 1960
+ +ES+ R +E +P +S+ ++ + ++ ++ ++E +
Sbjct: 3999 QI------------LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYE 4046
Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
+ GE ++ R ++I K Q + ++ WE + L+E R+A +
Sbjct: 4047 TLKQRGEEMIARSGGTDKDISAKAVQ------DKLDQMVFIWENIHTLVE----EREAKL 4096
Query: 2021 AEAWLIAQE 2029
+ +A++
Sbjct: 4097 LDVMELAEK 4105
Score = 94.7 bits (234), Expect = 8e-19
Identities = 157/754 (20%), Positives = 293/754 (38%), Gaps = 78/754 (10%)
Query: 307 YSGLASDLLTWIEQTIT-VLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
+ G DL W+ T +L S+ ++QL +E F+ K
Sbjct: 4434 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH-----MEVCAAFEAKEETYKS 4488
Query: 366 LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLAR 425
L +M A K + + ++++ WES+E R+ L L LA
Sbjct: 4489 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL-------NLAM 4541
Query: 426 RFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDL 484
F WL++ Q L L V +H+ + ++ E++ L+
Sbjct: 4542 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4601
Query: 485 AQELEKENYHDQKRITARKDNIL----RLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
L+ Y QK+ N+L W + + L R + L+ K F +
Sbjct: 4602 GTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4658
Query: 541 I-DWMDEIKAHLLSA-EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGK 598
+ +W++E + L S E +++ L +HK + + + V T T + + K
Sbjct: 4659 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK-HSVYDTTNRTGRSLKEK 4717
Query: 599 GYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAE-SWIKEKE 657
D + D +S L ++ + + R+ +LE++ F + +A W+ E
Sbjct: 4718 TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4777
Query: 658 -QIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEA 716
Q+ D+ V+ L HKAF+ EL + ++ + + A ++ + ++
Sbjct: 4778 PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV 4837
Query: 717 RIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHRLLSGEDV-GQD 774
+++E+S +W+ + L+ + L+ A +F L WL +A + L V D
Sbjct: 4838 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4897
Query: 775 EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD----VTHRLQALRELY 830
E A R L +HK+F+++LEE R + + G PD + H + +R +
Sbjct: 4898 EDALRTLIDQHKEFMKKLEEKRAELN--KATTMGDTVLAICHPDSITTIKHWITIIRARF 4955
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME---MPDTLEDLEVV 886
++V+A A QQRL AL E +A W+ E L + + +P +E+++ +
Sbjct: 4956 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5015
Query: 887 QHRFDILDQEMKTLMTQIDGVN-----------------------------LAANSLVES 917
+EM +D V A+SL S
Sbjct: 5016 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5075
Query: 918 GHPRSREVKQYQDHLN-TRWQAFQTLVSERREAVDSAL-------RVHNYCVDC--EETS 967
G E K + +L ++WQ L ERR ++ AL N+ D ++
Sbjct: 5076 GSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYM 5135
Query: 968 KWIT-DKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
+W+ K++V++ + + +D G I Q + G+
Sbjct: 5136 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5169
Score = 62.8 bits (151), Expect = 4e-09
Identities = 59/292 (20%), Positives = 127/292 (43%), Gaps = 27/292 (9%)
Query: 515 ELLQSRRQRLETTLALQKLFQDMLHS------IDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
+L+Q R+ L+++L Q L ++ ++ ++W+DE++ L E+G L VE L+
Sbjct: 609 KLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE 668
Query: 569 KHK-----LMEADIAIQGDKVKAIT-AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEEL 622
HK + E + +++ K+ I A LK T +++ LE + +L
Sbjct: 669 NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA------------EKLHRLESQYAKL 716
Query: 623 SNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF 682
N + ++ L+ L F W+ EKE+ + D+ + T++ + H
Sbjct: 717 LNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL 773
Query: 683 EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
EL + +++ + + A ++ IEA + QW + L ++++++
Sbjct: 774 MRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN 833
Query: 743 ENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEE 794
+F+F DA + +L++ + + + L ++ +EE EE
Sbjct: 834 TAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 885
Score = 59.7 bits (143), Expect = 3e-08
Identities = 68/313 (21%), Positives = 135/313 (43%), Gaps = 39/313 (12%)
Query: 293 VIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEK 352
++D + E++ K+ DLL W+++ L+ ++ + L V+ L+ ++ V +
Sbjct: 622 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE---NHKNVHR 675
Query: 353 PPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRN 412
+ E E + IQ M A + Y +L E++Y + L N
Sbjct: 676 AIEEFESSLKEAKISEIQ--MTAPLKLTYAEKLHRL------------ESQYAK---LLN 718
Query: 413 ELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA--VEAAKKK--HEAIE 468
QE+ F +A WL+E + ++ YD + A+KK H +
Sbjct: 719 TSRNQERHLDTLHNFVSRATNELIWLNEKE----EEEVAYDWSERNTNIARKKDYHAELM 774
Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
+ EE +++++++A++L EN+ + I A + + WS++ +L Q Q ++
Sbjct: 775 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 834
Query: 529 ALQKLFQDMLHSIDWMDEIKAHL---LSAEFGKHLLEVEDLLQ-----KHKLMEADIAIQ 580
A + F D + D++ +K + S + + ++EDL+Q K +L++ I
Sbjct: 835 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 894
Query: 581 GDKVKAITAATLK 593
KA T LK
Sbjct: 895 NLMGKAKTIIQLK 907
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/248 (19%), Positives = 103/248 (41%), Gaps = 11/248 (4%)
Query: 1599 WIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL-ASRAQGLLSAGHPE 1657
W+ E ++ + E D L+ H RA+E++ ++K+ S Q
Sbjct: 643 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTY 702
Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
E++ RL+ Q YA L + + ++R L+ +++ + R T++L W++EKE + +
Sbjct: 703 AEKLHRLESQ----YAKLLNTSRNQERHLDTLHNF--VSRATNEL-IWLNEKEEEEVAYD 755
Query: 1718 MGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNE 1777
+ ++ +D + RE +E + +V E+L+ H TI ++ +
Sbjct: 756 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 814
Query: 1778 MWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRV 1837
W+ +L+L Q + + +F E + + D S+ S H++
Sbjct: 815 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS--SIHKL 872
Query: 1838 HTAFEREL 1845
+ +
Sbjct: 873 EDLVQESM 880
Score = 51.2 bits (121), Expect = 1e-05
Identities = 147/816 (18%), Positives = 311/816 (38%), Gaps = 106/816 (12%)
Query: 1249 VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNL 1308
+Q +E RK E E S L L Q L + E+ K+ Q + + +
Sbjct: 1335 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATV 1391
Query: 1309 HNKWLKHQAFVAELASHEG-------WLENIDAEGKQLMDEKPQFTALVSQKLE------ 1355
+ L+ + A + S + + D ++ MD + ++TALV+ +
Sbjct: 1392 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1451
Query: 1356 -ALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLR-SDDPGKDLTS 1413
+L RL +E ++ +EK +H+ A+ +L KW+S + L+ ++ GK S
Sbjct: 1452 DSLKRLEEEEKSLEEEKKEHVEKAK----------ELQKWVSNISKTLKDAEKAGKPPFS 1501
Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
K K ++++ +KE+L E + + GD E+ L+ +
Sbjct: 1502 ------KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1555
Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH--- 1530
L S + Q+ + VEE++ + +Y LQ + + + +N ++GH
Sbjct: 1556 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQT---ENRLIGHQEA 1612
Query: 1531 ------TPRVEDVLQRGQQLVEAAEIDCQDLEERL----GHLQSSWDRL-REAAAGRLQR 1579
T ++ + ++L + + Q L E + L+ + ++L +E A Q+
Sbjct: 1613 FMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQK 1672
Query: 1580 LRDAN-EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR 1638
L +A + +Q L A++++ + + I +E K A+ L+ + + D+
Sbjct: 1673 LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK--VAAVKQLEESKTKIENLLDWLS 1730
Query: 1639 NIKQLASRA---------QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
N+ + + RA Q +G+ I + +V+ + DV + EN+
Sbjct: 1731 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-TDVDGQVGTTQENL 1789
Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
+Q + E+ IS+ + V + + Q LL + + + E Q+ +
Sbjct: 1790 NQQYQKVKAQH--EKIISQHQAVIIATQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKE 1842
Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ E + + ++ L + AD E L + +L +I
Sbjct: 1843 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF---EHWLQQSEQELENLEAGADDI 1899
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869
GL+ + R+ +SF + + +L + + + + A G+
Sbjct: 1900 NGLMTKLKRQ------------KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1947
Query: 1870 -----KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR-DLLSWMESII 1923
+Q K + +++L C L D DK++ + A LL+ +++
Sbjct: 1948 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2007
Query: 1924 R----------QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
++ + R + + L +E K L+ SLL
Sbjct: 2008 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL--- 2064
Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLL 2009
A +I++ L ++ R +++++ R E+L++ L
Sbjct: 2065 -PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2099
Score = 50.4 bits (119), Expect = 2e-05
Identities = 136/759 (17%), Positives = 292/759 (38%), Gaps = 123/759 (16%)
Query: 964 EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
++ W+ D+ +V + G DL + + + R + ++ + E + ++
Sbjct: 638 QDLLNWV-DEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK--EAKISEIQM 694
Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
+ P K ++ LE + L + + QE L L F+ + WL+ ++
Sbjct: 695 TAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEE 750
Query: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
+ D E + HA + E+D +++ + V+E E+++ + P L +
Sbjct: 751 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL-ENHPARLTIEAYR 809
Query: 1144 EGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAA 1203
+ T W+ + ++ + + + + EF DAK+A L N + + D
Sbjct: 810 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCD----R 865
Query: 1204 EAGIRKFEDFLGSMENNRDKVLS-------------------------PVDSGNKLVA-- 1236
+ I K ED + ++++L P+ + + A
Sbjct: 866 SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAIC 925
Query: 1237 -----EGNLYSDKIKEKVQLIEDRHR-------KNNEKAQEASVLL------RDNLELQN 1278
E +Y D ++ L + HR +A SV ++ ++L N
Sbjct: 926 DYRQIEITIYKD---DECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN 982
Query: 1279 FLQNCQE--LTLW----INDKLLTSQDVSYDEARNLHNKWL---------KHQAFVAELA 1323
++ + LTLW IN K + S +E + + +HQ ++ L
Sbjct: 983 RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQ 1042
Query: 1324 SH-EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ-------HL 1375
S E +LE D++ Q+ + +++ + + EL + + + Q ++
Sbjct: 1043 SRFEDFLE--DSQESQVFSGSD--ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI 1098
Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKD---LTSVNRMLAKLKRVEDQVNVRK 1432
S R+ LRL+ D + I + L DD + +T ++ +L+R++D +
Sbjct: 1099 SEVRNIRLRLENCED--RLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 1156
Query: 1433 EELGELFAQ------VPSMGEE------GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480
+ E F+Q VP++ E + S+ ++D L+ + K +++ A
Sbjct: 1157 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1216
Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
+++ ET EE +A N++ + +K+ ++ +E +ED LQ+
Sbjct: 1217 VKLY-----ETKLCEEEAVIADK----NNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1267
Query: 1541 GQQL-------VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
+ + + ++D +E+ L W + RL+ L ++ +YY D
Sbjct: 1268 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1327
Query: 1594 -DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQR 1631
+ WI Q++ +I +++ L L QQ+
Sbjct: 1328 YHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQK 1364
Score = 35.4 bits (80), Expect = 0.60
Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 9/224 (4%)
Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV-----EDQVNVRKEELG 1436
++ ++ DL W+ M+ QL + G DL SV L K V E + ++++ ++
Sbjct: 631 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 690
Query: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEE 1496
E+ P + + +E ++ LL +++ L++ +SR +E +W+ E
Sbjct: 691 EIQMTAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN--FVSR-ATNELIWLNE 746
Query: 1497 RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLE 1556
+ + D+ + + L E+ ++ V + +QL+ +E
Sbjct: 747 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 806
Query: 1557 ERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
+Q+ W + + Q +++ +++ DA EA ++
Sbjct: 807 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 850
Score = 33.9 bits (76), Expect = 1.8
Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 32/212 (15%)
Query: 1808 EILGLIDEKHRELPE-----DVGLDASTAESFHRVHTAFER-ELHLLGVQVQQFQDVATR 1861
++L +DE +L D+ S E+ VH A E E L ++ + Q A
Sbjct: 639 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP- 697
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L+ YA K + + + LL+ + L DT F S A + L W+
Sbjct: 698 LKLTYA--------EKLHRLESQYAKLLNTSRNQERHL-DTLHNF--VSRATNELIWLNE 746
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ + +++ YH + E++ + +N + E+ E LL H A I
Sbjct: 747 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 806
Query: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
+ R M +W W +L++CQ
Sbjct: 807 -------AYRAAMQTQWS--W-----ILQLCQ 824
Score = 32.0 bits (71), Expect = 6.7
Identities = 47/286 (16%), Positives = 105/286 (36%), Gaps = 20/286 (6%)
Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
DL W+ E ++ E G D V + ++ R + F L +A
Sbjct: 639 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA-----------IEEFESSLKEA 687
Query: 1761 GHSEAATIAEWK----DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGA-EILGLIDE 1815
SE A K + L+ + + +L++T LH + E++ L ++
Sbjct: 688 KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 747
Query: 1816 KHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQ 1875
+ E+ D + H REL ++ Q++A +L + I+
Sbjct: 748 EEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL-TIE 806
Query: 1876 NKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQ---ERP 1932
+ W +L C + + F FF+ A++ ++ ++ I+ + +R
Sbjct: 807 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS 866
Query: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASE 1978
+ +E L++ E+ + + ++++Q + + S+
Sbjct: 867 SSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 912
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 298 bits (763), Expect = 4e-80
Identities = 172/388 (44%), Positives = 234/388 (60%), Gaps = 15/388 (3%)
Query: 48 LADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGK 107
+ADER+ VQKKTFTKW+N HL +V + DLY+DLRDG LI LLEVLSG+ LP+ KG+
Sbjct: 69 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 127
Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ 167
MR H L+NV AL +LK ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V +
Sbjct: 128 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 187
Query: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKD 227
E SAK+ LLLW Q T GY + NFT+ W+DG FNA+IHK+RPDLID + +
Sbjct: 188 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 245
Query: 228 SNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEG 287
+ NLEHAF VAE+ +G+I LLDPEDV +PDEKS+ITYV + Y F K + G
Sbjct: 246 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK---VPEGG 301
Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTY 347
+ +G A + E +Y + + L+ WI +T ++ R F N+ ++ + +
Sbjct: 302 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 356
Query: 348 RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRE 407
+ E PPK EK ++ L ++ + K+ G +DI + W L A RE
Sbjct: 357 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 413
Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRE 435
ALR E+ R E L+Q+A R R + + E
Sbjct: 414 KALRPEVERLEMLQQIANRVQRDSVICE 441
Score = 171 bits (432), Expect = 9e-42
Identities = 321/1659 (19%), Positives = 676/1659 (40%), Gaps = 141/1659 (8%)
Query: 387 KLVSDINRAWESL-EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRL 444
K +S ++ WE+L +AE R + E + +A++F WL+ +RL
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNR--------QLEGISVVAQQFHETLEPLNEWLTTIEKRL 3478
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
V + G + +E +H+A+E D + + + + Q L+ + + K + K
Sbjct: 3479 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3538
Query: 505 NILRLWSY-LQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEIKAHLLSAEFGKHLLE 562
+ ++W +QE SR + L+ L K+F +D + ++W++E+ L + E
Sbjct: 3539 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3598
Query: 563 VEDLLQKH-KLMEADIAIQGDKVKAITA---ATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
Q ++++ DI ++ V LK T G + +IQD++ ++
Sbjct: 3599 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGD-----EVLIIQDKLEAIKAR 3653
Query: 619 FEELSNMAAGRKAQLEQSKRLWKFFWEM-DEAESWIKEKEQIYSSLDY----GKDLTSVL 673
+++++ ++ LEQ+ +L + +E +W+ + E S + G++ +
Sbjct: 3654 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA- 3712
Query: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQLKDLA 732
Q + K + E + A L+ + + + ++ + +E + E + ++ + D
Sbjct: 3713 --QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3770
Query: 733 AFCKKNLQDAE-NFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKHKDFLE 790
+ + A QF AD +W+ + + L+S D+ ++ T A + K F
Sbjct: 3771 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3830
Query: 791 ELEESRGVMEHLEQQAQGF----PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
E+ + +++ L + EE + S + +L + + Y + R +L+
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLER 3888
Query: 847 ALDLYTVFGET-DACELWMGEKEKWLAEMEMPDT-LEDLEVVQHRFDILDQEMKTLMTQI 904
A L F ET + W+ E + ++++ P E L Q L + + I
Sbjct: 3889 AQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 3948
Query: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
D +N L+E +++ +T + + V +R A+D A+ D
Sbjct: 3949 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD-- 4006
Query: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLS---GLERDVAAIQARVDALERESQQL 1021
+ + + ++VE + A + I+ ++S + D+ +Q + L++ +++
Sbjct: 4007 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066
Query: 1022 MDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-QAFLQDLDDFQA 1075
+ +DI + Q L+++ W+ + ++ +E L +V +L + F D
Sbjct: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126
Query: 1076 WLSITQKAVASEDMPESLPEAEQLLQQHAG-IKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134
+ TQ + + P P + Q+ A I++EIDG Q+ V G ++I +P
Sbjct: 4127 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4186
Query: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAE-AILSNQEYTLAH 1193
+ ++ + ++ L++ W++L + W+ R L + + +D QA + LA
Sbjct: 4187 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLAS 4246
Query: 1194 LEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-------- 1244
+ P LE + I + + F + ++ L+ + SDK
Sbjct: 4247 MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLM 4306
Query: 1245 -IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI--NDKLLTSQDVS 1301
+K +E+R K + A L L F EL W+ + LL+ Q
Sbjct: 4307 ELKLIWDSLEERIINRQHKLEGAL------LALGQFQHALDELLAWLTHTEGLLSEQKPV 4360
Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP-QFTALVSQKLEALHRL 1360
+ + + + KH ++ +H+ +E ++ G L++ + + + KLE L++
Sbjct: 4361 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4420
Query: 1361 WDELQATTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDP-------GKDLT 1412
W + T+++ Q L A R + DL +W++ E L + P K+
Sbjct: 4421 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4480
Query: 1413 SVN-RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL-SIEKRFLDLLEPLGRR 1470
+V+ + A + E+ ++ ++ A+ P E D D+ ++++++ + L R
Sbjct: 4481 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4540
Query: 1471 KKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
K +LE + ++ L+D W+ E+ L +A L TV + +++ NE
Sbjct: 4541 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP--SLILDTVLFQIDEHKVFANE 4598
Query: 1527 ILGHTPRVEDVLQRGQQL-VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE 1585
+ H ++ ++ + G L + + D ++ L +QS W+++ + R + L DA +
Sbjct: 4599 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4658
Query: 1586 -AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQRAV---------- 1633
A+Q++ + W+ E E + S+ EI D + L +H Q+++
Sbjct: 4659 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4718
Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693
GR++K+ S A L + + L+ + D + + ER+ KLE L
Sbjct: 4719 NRTGRSLKEKTSLADDNLKL----DDMLSELRDKWDT----ICGKSVERQNKLEEA--LL 4768
Query: 1694 QLKRETDDLEQWIS-----EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVD 1748
+ TD L+ I E +L P G D D V L D + F +E G +R
Sbjct: 4769 FSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELG----KRTS 4823
Query: 1749 NVNAF---IERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY----DLHR 1801
+V A LI+ +++ + L+ W + L ++ L A+ + H
Sbjct: 4824 SVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHS 4883
Query: 1802 YFYTGAEILGLIDEK---HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
+ E L ++ H LP+ D + H F ++L ++ + +
Sbjct: 4884 VVHALLEWLAEAEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTM 4939
Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA-----DKFRFFSMAR 1913
+ + I++ + A ++ +L A A + Q + +A K
Sbjct: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVL-AWAKQHQQRLASALAGLIAKQELLEALL 4998
Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
L W E+ + + + P+++ V+ L+ HQ E+
Sbjct: 4999 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037
Score = 157 bits (397), Expect = 1e-37
Identities = 322/1813 (17%), Positives = 717/1813 (39%), Gaps = 209/1813 (11%)
Query: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
++ I W++ + RE L+ L + A ++ + W+ + Q + +
Sbjct: 2883 LNTIKTNWDTFNKQVKERENKLKESL-------EKALKYKEQVETLWPWIDKCQNNLEEI 2935
Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
F D A E + K ++++ + + V L + A L D++ +T ++++
Sbjct: 2936 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 2995
Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQDML-----------HSIDWMDEIKAHLLSAEFG 557
+ E L S++ LE K FQ++ +D D + + S ++
Sbjct: 2996 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3055
Query: 558 KHLLEVEDLLQ--KH-----KLMEADIAIQGDKVKAITAATLKF-TEGKGYQPCDPQV-- 607
L + LQ KH K + D+ ++ K + L+ T + + QV
Sbjct: 3056 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3115
Query: 608 ------------------IQDRISHLEQCFEELSNMA-AGRKAQLEQSKRLWKFFWEMDE 648
I++ S + +EL +MA GR A+ Q ++ +
Sbjct: 3116 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQK--------ET 3167
Query: 649 AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
++++K+ E + +S D +++ + +L G+ LE + ++ + ++ R Q
Sbjct: 3168 IKAFLKKLEALMASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDRAQ 3224
Query: 709 FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
Q+E IK + + +LK+ + LQ AE + QG +
Sbjct: 3225 AREEQVEGTIKRLEEFYSKLKEFSIL----LQKAEEHEESQGPVG------------MET 3268
Query: 769 EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD---VTHRLQA 825
E + Q + K EE+E +G + + QG + S + H L
Sbjct: 3269 ETINQQLNMFKVFQK------EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3322
Query: 826 LRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLE 884
+ ++ + + R +LQEAL F + ++ WM + E+ +A + P + +
Sbjct: 3323 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA--EFK 3380
Query: 885 VVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EVKQYQDHLNTRWQAFQ 940
VV+ + +L + + + ++ + + + P + ++ + L++RW+A
Sbjct: 3381 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3440
Query: 941 TLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
R ++ ++ + E ++W+T K + + + +G + + +
Sbjct: 3441 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKA 3500
Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ-GLQQSLQGQEDLLG 1058
LE D+ + Q L + +D+ Q + ++W +Q+ + +LL
Sbjct: 3501 LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQ 3560
Query: 1059 E-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI-KDEIDGHQDS 1116
+ + + F +D + WL+ ++ + + E Q + +++I + +
Sbjct: 3561 QALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQN 3620
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ---------- 1166
+ +G ++++ T E L++ +LE + + + ++ + TL Q
Sbjct: 3621 VDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHS 3680
Query: 1167 -----CLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
C + + + E +L +E + A + P + + A + + L S+
Sbjct: 3681 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA----KNNKALLDSLNEV 3736
Query: 1221 RDKVLSPV-----DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
+L V + K+VAE N L SD I +KV+ I+ + +LR
Sbjct: 3737 SSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-------------AAILR 3783
Query: 1272 DNLELQNFLQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
Q F Q WI + KL++ D+ ++ + ++ + F E+ H+
Sbjct: 3784 S----QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQ-KTFTMEILRHKDI 3838
Query: 1329 LENIDAEGKQLM----DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
++++ G ++M +E+ Q + +KL+ + + +D + E+ L A+S +
Sbjct: 3839 IDDLVKSGHKIMTACSEEEKQ---SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 3895
Query: 1385 L-QTHADLNKWISAMEDQL-RSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV 1442
+T+ +L W++ + + + P + ++ + + +++ + + K + ++
Sbjct: 3896 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 3955
Query: 1443 PSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
P + E SI+++++ + E + +R L+ + ++ D D+ L
Sbjct: 3956 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4015
Query: 1496 ERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA----- 1548
ER+ L Q ++ ++ + +N+ + ++ P E + QRG++++ +
Sbjct: 4016 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4075
Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYV 1607
+I + ++++L + W+ + R +L D E A++++ D I + + ++
Sbjct: 4076 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4135
Query: 1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR--------AQGLLSAGHPEGE 1659
E P + + +QQ A E I L ++ + + G P+
Sbjct: 4136 RDLEDPGIDPSVV------KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4189
Query: 1660 QIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQW--ISEKELVASSP 1716
+ + +++ + L ++R KLE M Q + + W I+ +L + SP
Sbjct: 4190 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4249
Query: 1717 EMGQDFDHVTLLRDKFRDFARET--GAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDG 1774
+G D + V ++ + F E I ER+++ + + + S+ T+ +
Sbjct: 4250 -IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV-TEESDKHTVQDPLME 4307
Query: 1775 LNEMWADLLE-LIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPED--VGLDASTA 1831
L +W L E +I+ + +L A L ++ + E+L + L E VG D
Sbjct: 4308 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367
Query: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
E H + ++ V+ L + AGE+A +QNK + ++ WQ +L+
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4427
Query: 1892 CAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYHQGIN 1949
R+ QL + + F DL W+ R + + + + + + H +
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4487
Query: 1950 AEIETRSKNFSACLELGESLLQRQHQASE--------EIREKLQQVMSRRKEMNEKWEAR 2001
A E + + + + ++ G+ +L R +++E ++EK + V ++ E K E
Sbjct: 4488 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE-- 4545
Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYL-ASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
E L + +E F WL E L + +D+V I H+ F S
Sbjct: 4546 -EALNLAME---FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4601
Query: 2061 WAERFAALEKPTT 2073
E+ L+K T
Sbjct: 4602 HREQIIELDKTGT 4614
Score = 155 bits (393), Expect = 3e-37
Identities = 308/1553 (19%), Positives = 632/1553 (40%), Gaps = 124/1553 (7%)
Query: 606 QVIQDRISHLEQCFEELSNMAAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLD 664
Q ++ + + ++ L+ A R AQL+++ +F ++ SW+ + E++ ++
Sbjct: 3314 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3373
Query: 665 YGKDLTSVLILQ-RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHP-QIEARIKEVS 722
V+ Q ++ K + L + +E I +E + + +I ++ +
Sbjct: 3374 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3433
Query: 723 AQWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAH-RLLSGEDVGQDEGATRA 780
++W+ L + A + L+ Q F + L WL RL++ E +G
Sbjct: 3434 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3493
Query: 781 LGKKHKDFLEELEESRGVMEHLEQ-----QAQGFPEEFRDSPDVTHRLQALRELYQQVVA 835
+HK +++ +HL Q Q+ D V +L + Y ++
Sbjct: 3494 QIAQHKALEDDIINHN---KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3550
Query: 836 QADLRQQRLQEALDLYTVFGETDACEL--WMGEKEKWLAEMEMPD-TLEDLEVVQHRFDI 892
++ R + LQ+AL +FGE D EL W+ E L+++ + D + E L Q +
Sbjct: 3551 KSHSRSELLQQALCNAKIFGE-DEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3609
Query: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNT---RWQAFQTLVSERREA 949
L +++ +D L L++ EV QD L R++ L ++ +
Sbjct: 3610 LQEDILLRKQNVDQALLNGLELLKQ--TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3667
Query: 950 VDSAL----RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKL--SGLERD 1003
++ AL R+H+ EE W+ DK +V E + L G A Q ++ L+++
Sbjct: 3668 LEQALQLARRLHS---THEELCTWL-DKVEV-ELLSYETQVLKGEEASQAQMRPKELKKE 3722
Query: 1004 VAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQSL-QGQEDLLGEVS 1061
+A +D+L S L++ P +E + + E ++ + ++ Q E++ +
Sbjct: 3723 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3782
Query: 1062 QLQAFLQDLDDFQAWLSITQKAVAS-EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRV 1120
+ Q F Q D +W++ T+K + S D+ + LQ EI H+D +
Sbjct: 3783 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3842
Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGF-QEFQKDAKQ 1179
+SG K++ ++ E + ++L+ + ++ + ++ R L + +F + ++
Sbjct: 3843 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 3902
Query: 1180 AEAILSNQEYTLAHLEPP----DSLEAAEAGIRKFEDFLGSMENNRDKV---------LS 1226
L+ + ++ L P ++L + R+ + + + + DK+ LS
Sbjct: 3903 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 3962
Query: 1227 PVDSGN---KLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNC 1283
P + + K VA LYS +IKE V+ ++A + + + + +
Sbjct: 3963 PGEGFSIQEKYVAADTLYS-QIKEDVK----------KRAVALDEAISQSTQFHDKIDQI 4011
Query: 1284 QELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM--- 1340
E I ++L +S E + + +++ ++ + E + G++++
Sbjct: 4012 LESLERIVERLRQPPSISA-EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4070
Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEK-TQHLSAARSSDLRLQTHADLNKWISA 1397
+K V KL+ + +W+ + +E+ + L ++ H L I
Sbjct: 4071 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4130
Query: 1398 MEDQLRS-DDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSI 1456
+D +R +DPG D + V + + + ++++ +EEL + + G+ D I
Sbjct: 4131 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4190
Query: 1457 EKRFLDLLEPL---------GRRKKQLESSRAKLQISRDLEDETLWVE-ERLPLAQSADY 1506
K+ +D L R K E+ +A +Q L+ WV+ LA +
Sbjct: 4191 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4250
Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQS 1564
GT+L+TV+ +++ + ++E +E + + + L++ E D +++ L L+
Sbjct: 4251 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310
Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAEAWIGEQELYVISDEIPK--DEEGAIV 1621
WD L E R +L A A + A DE AW+ E ++S++ P D + +
Sbjct: 4311 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE-GLLSEQKPVGGDPKAIEI 4369
Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDV 1678
L +H Q V + ++ + L+ + GE+ LQ +++ + + + +
Sbjct: 4370 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS--AGEEASNLQNKLEVLNQRWQNVLEK 4427
Query: 1679 AEERKRKLENMYHLFQ-LKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDF 1735
E+RK++L+ + E +DL+QW++ E+ L+AS P G L +
Sbjct: 4428 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL-----NV 4482
Query: 1736 ARETGAIGQERVDNVNAFIER----LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
E A + + + + +++ L S I + + L E W + ++ R
Sbjct: 4483 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4542
Query: 1792 LLAASYDLHRYFYTGAE-ILGLIDEKHREL--PEDVGLDASTAESFHRVHTAFERELHLL 1848
L + +L F+ + + + + + L L T H F E++
Sbjct: 4543 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4602
Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
Q+ + T L+ + I+N V + W+ ++ R L D + +
Sbjct: 4603 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4662
Query: 1909 FSMA-RDLLSWMESIIRQIETQ-ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELG 1966
F A L+ W+E + ++++ E D ++ + H+ + + + G
Sbjct: 4663 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4722
Query: 1967 ESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAE 2022
SL ++ A + + KL ++S E+ +KW+ ER L E FS + A
Sbjct: 4723 RSLKEKTSLADDNL--KLDDMLS---ELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4777
Query: 2023 A----WLIAQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
WL EP LA H +D V LI H+AF+K AL++
Sbjct: 4778 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830
Score = 149 bits (375), Expect = 4e-35
Identities = 358/1838 (19%), Positives = 731/1838 (39%), Gaps = 212/1838 (11%)
Query: 359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE 418
K EVLL S + A N T D +V +S+ E + ++ L L Q+
Sbjct: 2061 KKTAEVLLDARGSLLPAKNDIQKTLDD--IVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2118
Query: 419 KLEQLARRFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEER 477
L+++ W+ L Q + A++ K+ +E D A +
Sbjct: 2119 GLDEML-----------DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2167
Query: 478 VRALEDLAQE-LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
+ A+ + ++ +E + + A+ ++ +S + ++E +LF++
Sbjct: 2168 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2227
Query: 537 MLHSIDWMDEIKAHLLSAEF--GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
+ + E K L+ GK + E+ +Q+ ++ K + + LK
Sbjct: 2228 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQE----STSEFLEHKKHLEVLHSLLKE 2283
Query: 595 TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKFFWEMDEAESWI 653
G P D ++ ++ ++L + F+E+ + +K + ++L F + +SWI
Sbjct: 2284 ISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWI 2342
Query: 654 KEK-------EQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------LEQIFQE 699
KE + + + D GK L LQ K E++ ++ + +
Sbjct: 2343 KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP 2402
Query: 700 AHGMVARKQFGH--------------------PQIEARIKEVSAQWDQL----KDLAAFC 735
A + A K G I+ + ++S ++ L KD A
Sbjct: 2403 AKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAEL 2462
Query: 736 KKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEGATRALGKKHKDFLEEL 792
L + + Q ++ + WLQ ++ + D A + +++K F EL
Sbjct: 2463 NTKLSKLQ---KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2519
Query: 793 EESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALD 849
+++ ++ L+ + EE D+P+ Q L E+ +Q++ RQQ+L+E+ +
Sbjct: 2520 KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSN 2579
Query: 850 LYTVFGETDA-CELWMGEKEKWLAEMEMPDTLED--LEVVQHRFDILDQEMKTLMTQIDG 906
T F +A + W+ EKE ++ + P +++ L + + IL QE T Q +
Sbjct: 2580 NLTQFQTVEAQLKQWLVEKELMVSVLG-PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2638
Query: 907 VNLAANSLVES-GHPRSRE--VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDC 963
+ A ++ G S VK+ + +W + +S+R + +D A+
Sbjct: 2639 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAI--------- 2689
Query: 964 EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
+++++ + + + DL L+ +A+ + + + Q +++E +Q+
Sbjct: 2690 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2749
Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQG--------QEDLLGEVSQLQA-------FLQ 1068
+ ED+ K E L L + L+G ++ V LQ+ F Q
Sbjct: 2750 AQA-LCEDLSALVKE-EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2807
Query: 1069 DLDDFQAWLSITQKAVASEDMPES--LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEK 1126
DFQAWL T+K ++ P S L E L++ H + Y++ GE
Sbjct: 2808 MSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN 2866
Query: 1127 VIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI--- 1183
++ E L +L + T W+ + + R + L + L ++ K +Q E +
Sbjct: 2867 LLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL--EKALKYKEQVETLWPW 2924
Query: 1184 -------LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NNRDKVLSPVDSGNK 1233
L ++ L E +S+ ++ ++ + G +E N + +LS + +
Sbjct: 2925 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 2984
Query: 1234 LVAEGNLYSDKIKEKVQLI-EDRHRKN---NEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
+V + N + +KV ++ E H K Q+ + E + LQ C + L
Sbjct: 2985 VVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ-CAKEQLD 3040
Query: 1290 INDKL----LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ 1345
I+D L +++ ++ + + + LKHQ +A+ + + +E D++G
Sbjct: 3041 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--------- 3091
Query: 1346 FTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS 1404
T+ V ++E + + L EK L Q T ++ + +D+L S
Sbjct: 3092 -TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDS 3150
Query: 1405 DDP-GKDLTSVNR----MLAKLKRVE----DQVNVRKEELGELFAQVPSMGEEGGDADL- 1454
P G+D ++ + + A LK++E N K L + S G DL
Sbjct: 3151 MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLE 3210
Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKLQ--ISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
++ K+ LL+ R++Q+E + +L+ S+ E L + G +T
Sbjct: 3211 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3270
Query: 1513 VQLFMKKNQTLQ-NEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRL 1569
+ + + Q EI + +DV GQ L+++A Q LE L + + W L
Sbjct: 3271 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3330
Query: 1570 REAAAGRLQRLRDANEAQQYYLDADEA-EAWIGEQELYVISDEIPKDEEGAI-VMLKRHL 1627
+ A R +L++A + DA E+ +W+ + E V + + P E + ++
Sbjct: 3331 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3390
Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGE-QIIRLQGQVDKHYAGLKDVAEERKRKL 1686
QR ++D ++ + + + + P + +I++ +D + L + AE R R+L
Sbjct: 3391 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3450
Query: 1687 ENMYHLFQLKRET-DDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
E + + Q ET + L +W++ EK LV P + K + + A+
Sbjct: 3451 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP--------IGTQASKLEEQIAQHKAL- 3501
Query: 1744 QERVDNVNAFIERLIDAGHS-------EAATIAEWKDGLNEMW-ADLLELIDTRMQLLAA 1795
++ + N N + + + G S E + + K +++W ++ E +R +LL
Sbjct: 3502 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3561
Query: 1796 SYDLHRYF-YTGAEILGLIDEKHRELPEDVGLDASTAESFHRVH--TAFERELHLLGVQV 1852
+ + F E++ ++E H +L + D ST + + + ++ L V
Sbjct: 3562 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3621
Query: 1853 QQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-----R 1907
Q L G++ IQ+K + + A ++ + T + T ++ R
Sbjct: 3622 DQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL----STDVAKTLEQALQLARR 3677
Query: 1908 FFSMARDLLSWMESI---IRQIETQE-RPRDVSSVELLMKYHQGINAEIETRSKNFSACL 1963
S +L +W++ + + ETQ + + S ++ K E++ +KN A L
Sbjct: 3678 LHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-------ELKKEAKNNKALL 3730
Query: 1964 ----ELGESLLQR-QHQASEEIREKLQQVMSRRKEMNEKWEARWERL-RMLLEVCQFSRD 2017
E+ +LL+ +A E + + + + R + +++ + E + +L QF +
Sbjct: 3731 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3790
Query: 2018 ASVAEAWLIAQEPYLAS-GDFGHTVDSVEKLIKRHEAF 2054
A +W+ E L S GD D ++ + F
Sbjct: 3791 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3828
Score = 129 bits (325), Expect = 2e-29
Identities = 389/2030 (19%), Positives = 780/2030 (38%), Gaps = 278/2030 (13%)
Query: 277 FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSG--LASDLLTWIEQTITVLNSRK---FA 331
FSK K+ + E + + A++T ++ G + + +E+ + L F+
Sbjct: 1511 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1570
Query: 332 NSLTGVQQQLQAFSTYRTV--------EKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTP 383
SL +QLQ T V E+ +++EK L T +Q+ +
Sbjct: 1571 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1626
Query: 384 HDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
DG + E ++ + + EL Q+ ++ A+ E +L EN
Sbjct: 1627 GDGTV--------------ELKKYQSKQEEL--QKDMQGSAQALAEVVKNTENFLKENGE 1670
Query: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
++Q++ + AK K E + ++ + + A + E E K++ K
Sbjct: 1671 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1730
Query: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH--------SIDWMDEIKAHLLSAE 555
I L +L + + T Q + Q+ H +I DE+ +LL +
Sbjct: 1731 TKIENLLDWLSNV--DKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1788
Query: 556 FGKHLLEVEDLL----QKHKLMEADIAIQGDKVKAIT--AATLKFTEGKGYQPCDPQVIQ 609
+ ++ L QK K I Q V T A L +G+ P + + +Q
Sbjct: 1789 VDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ 1848
Query: 610 DRISHLEQCFEE-LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYG-K 667
+ L+ +E L+ K + L KF + E E W+++ EQ +L+ G
Sbjct: 1849 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908
Query: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQI------FQEAHGMVARKQFGHPQIEARIKEV 721
D+ ++ ++ K+F +++ L I EA +++ G A +EV
Sbjct: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 1968
Query: 722 SAQWDQLKD----LAAFCK---KNLQDAENFFQFQGDAD-DLKAWLQDAHRLLS---GED 770
+ D D L + C NL+D + +Q DA L A LQ S E
Sbjct: 1969 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2028
Query: 771 VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE----FRDSPDVTHRLQAL 826
+ D + ++ K ++ + +E L++ A+ + D+ L +
Sbjct: 2029 IAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI 2088
Query: 827 RELYQQVVAQADLRQQRLQEALD-LYTVFGETDACELWMGEKEKWLAEM-EMPDTLEDLE 884
Y+ + + R ++LQ L +V D WMG E L E ++P L+
Sbjct: 2089 VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ 2148
Query: 885 VVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP----------------------RS 922
+ + +L+Q++ + I+ +N +E+ P +
Sbjct: 2149 DIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKH 2208
Query: 923 REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV-ESTK 981
+E + L T+ + F+ L + + +++ + + + K +T+ ++ + EST
Sbjct: 2209 KETLAKMEELKTKVELFENLSEKLQTFLETKTQA---LTEVDVPGKDVTELSQYMQESTS 2265
Query: 982 DL---GRDLAGIIAIQRKLS--GLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ 1036
+ + L + ++ +++S GL D A + + + L ++ +++ D+ E+KE + Q
Sbjct: 2266 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQ 2325
Query: 1037 KHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
+ L + +Q L +SL+ + + + I Q + +ED+ +SL +
Sbjct: 2326 EQL-DAFQVLVKSLKSW----------------IKETTKKVPIVQPSFGAEDLGKSLEDT 2368
Query: 1097 EQLLQQHAGIKDEIDGHQDS----------------YQRVKESGEKVIQGQ---TDPEYL 1137
++L ++ + EI +S +SG V+ G+ T+ E
Sbjct: 2369 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2428
Query: 1138 LLGQRLEG-------LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS----- 1185
+ L + G+ LG + + + L L + QK +++ A++
Sbjct: 2429 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL--SKLQKAQEESSAMMQWLQKM 2486
Query: 1186 NQEYTLAHLEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEG--NLYS 1242
N+ T P P EA + + + + F ++ N +KV D +L+ E +
Sbjct: 2487 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2546
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQ--- 1298
+ K+ + I+ + ++ N+ + L ++ L F +L W+ +K L
Sbjct: 2547 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2606
Query: 1299 DVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD---EKPQFTALVSQKLE 1355
+S D L+ + + Q + E A+ + E + A G+ ++ E P +V ++L
Sbjct: 2607 PLSID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2665
Query: 1356 ALHRLWDELQATTKEK-----------TQHLSAARSSDLRLQTHADL-NKWISAMEDQLR 1403
A+ + WD L ++ TQ+ S RS +L +DL NK S++
Sbjct: 2666 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL---SDLDNKLSSSLAVSTH 2722
Query: 1404 SDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLS-----IEK 1458
D + L + +M ++++ + Q+ V + +L A V EE A+LS I K
Sbjct: 2723 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK---EEYLKAELSRQLEGILK 2779
Query: 1459 RFLDLLEPLGRRKKQLESSRAK----LQISRDLEDETLWVE-ERLPLAQSADYGTNLQTV 1513
F D+ + + L+S+ A Q+SRD + W++ ++ +S L +
Sbjct: 2780 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVL 2836
Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQ-LVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
+ +K ++ + + E + G+ L++ + L+ +L ++++WD +
Sbjct: 2837 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 2896
Query: 1573 AAGRLQRLRDANE-AQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRH 1626
R +L+++ E A +Y + WI + +E+ D P + E +I LK
Sbjct: 2897 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLK-- 2952
Query: 1627 LRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKL 1686
Q+ ++ + ++ L + A LLS + E + + + + + +K L
Sbjct: 2953 -SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3011
Query: 1687 ENMYHLFQLKRET--DDLEQWISEKELVASSPEMGQDF---DHVTLLRDKFRDFARETGA 1741
ENM F+ +E + Q KE + +G ++T+L+ + +
Sbjct: 3012 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3071
Query: 1742 IGQERVDNVNAFIERLIDAGHS----EAATIAEWKDGLNEMWADLLELIDTRMQLLAASY 1797
+ + + +E G S + TIA+ L++ + ++T++Q +
Sbjct: 3072 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3131
Query: 1798 DLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELH-LLGVQVQQFQ 1856
+ R + ++ DE P VG DA T + AF ++L L+ +
Sbjct: 3132 NTIREMF--SQFAEFDDELDSMAP--VGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3187
Query: 1857 DVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMARDL 1915
L T I+ + +S LLD R Q+ T + F+S ++
Sbjct: 3188 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3247
Query: 1916 LSWMESIIRQIETQ----ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
++ E+Q ++ + K Q EIE LG+ L+Q
Sbjct: 3248 SILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQ 3305
Query: 1972 --RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQE 2029
+ +++ + L V +R K +N+K R +L+ L C
Sbjct: 3306 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC----------------- 3348
Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASW---AERFAALEKPTTLELK-------ER 2079
G D++E L+ SW E A +KP + E K E+
Sbjct: 3349 --------GRFQDALESLL-----------SWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3389
Query: 2080 QIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESL 2129
++ +R ++ E + GE + ++ + S L S WE+L
Sbjct: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3439
Score = 102 bits (254), Expect = 4e-21
Identities = 315/1749 (18%), Positives = 686/1749 (39%), Gaps = 177/1749 (10%)
Query: 387 KLVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRFDRKAAMRETWLSENQRLV 445
K ++DI+ +E L L L++++ KL +L + + +AM + WL + +
Sbjct: 2439 KDMTDISHGYEDLG-------LLLKDKIAELNTKLSKLQKAQEESSAMMQ-WLQKMNKTA 2490
Query: 446 A---QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN--YHDQKRIT 500
Q D AV+ +++++ E + +V+ L+D EL +EN + R
Sbjct: 2491 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2550
Query: 501 ARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFGKH 559
I W L +L R+Q+LE + FQ + + W+ ++ L+ + G
Sbjct: 2551 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPL 2608
Query: 560 LLEVEDL---LQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
++ L Q+ +++ + A + + + +TAA G P +++++++ +
Sbjct: 2609 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2668
Query: 617 QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
Q ++ L+ + R ++Q+ + + +S ++ S LD L+S L +
Sbjct: 2669 QKWDSLTGQLSDRCDWIDQA------IVKSTQYQSLLRSLSDKLSDLD--NKLSSSLAVS 2720
Query: 677 RKHKAFEDELRGLDAHLEQIFQEAH------------GMVARKQFGHPQIEARIKEVSAQ 724
A +L ++I QE + ++++ ++ +++ +
Sbjct: 2721 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2780
Query: 725 WDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQ-DAHRLLSGEDVGQDEGATRALG 782
+ ++ A ++LQ A + QFQ + D +AWL + +L
Sbjct: 2781 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLI 2840
Query: 783 KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ--ALRELYQQVVAQADLR 840
K HKDF + L + E + + + + S +LQ ++ + Q R
Sbjct: 2841 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 2900
Query: 841 QQRLQEALDLYTVFGE-TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKT 899
+ +L+E+L+ + E + W+ + + L E++ + E + L +EM
Sbjct: 2901 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 2960
Query: 900 LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNY 959
++ +N ANSL+ V L + + ++ +++ +
Sbjct: 2961 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK- 3019
Query: 960 CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK----LSGLERDVAAIQARVDALE 1015
+ +E SK + + + D+ D G A K L ++ + A++ +VD +
Sbjct: 3020 --EFQEVSKESKRQLQCAKEQLDI-HDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3076
Query: 1016 RESQQLMDSHPEQK--EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDF 1073
R +Q L+ + K D+ + + + + L Q + + S L+ LQ + F
Sbjct: 3077 RLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD------EKCSFLETKLQGIGHF 3130
Query: 1074 QAWL--SITQKAVASEDMPESLP---EAEQLLQQHAGIK---DEIDGHQDSYQRVKESGE 1125
Q + +Q A +++ P +AE L +Q IK +++ S ++ +
Sbjct: 3131 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3190
Query: 1126 KVI-QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCL-GFQEFQKDAKQAEAI 1183
++ +T P+ + + + LE L N L ++R + + +EF K+ +
Sbjct: 3191 MMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSIL 3250
Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
L E H E + I + + + + L + +G + S
Sbjct: 3251 LQKAE---EHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA 3307
Query: 1244 KIKEKVQLIED-------RHRKNNEK-AQEASVLLRDNLELQNFLQNCQELTLWIND--K 1293
Q +E R + N+K AQ A+ L L F + L W+ D +
Sbjct: 3308 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3367
Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL-MDEKPQFTALVSQ 1352
L+ +Q E + + + + + L + +E I EG+++ +P + +
Sbjct: 3368 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3427
Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTH---ADLNKWISAMEDQLRSDDP-G 1408
+L L W+ L K +T++ S + Q H LN+W++ +E +L + +P G
Sbjct: 3428 QLSLLDSRWEAL--LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3485
Query: 1409 KDLTSVNRMLAKLKRVEDQVNVRKEELGEL--FAQVPSMGEEGGDADLSIEKR------F 1460
+ + +A+ K +ED + + L + Q + D D+ K +
Sbjct: 3486 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3545
Query: 1461 LDLLEPLGRRKKQLESSRAKLQISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLF 1516
+++ E R + L+ + +I + E E + W V ++L DY T Q
Sbjct: 3546 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ-- 3603
Query: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEID-CQDLEERLGHLQSSWDRLREAAAG 1575
+ + LQ +IL V+ L G +L++ D ++++L +++ + + + +
Sbjct: 3604 QSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3663
Query: 1576 RLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISDE--IPKDEEGAIVM-----LKRHL 1627
+ L A + A++ + +E W+ + E+ ++S E + K EE + LK+
Sbjct: 3664 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3723
Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
+ +A+ D ++ +++S L+ EG + ++ + ++ Y + D ++ +++
Sbjct: 3724 KNNKALLD---SLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEID 3778
Query: 1688 NMYHLFQLKRETDDLE-QWISEKE-LVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQE 1745
Q + D E WI+E E + S ++ + D + + F E
Sbjct: 3779 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME------- 3831
Query: 1746 RVDNVNAFIERLIDAGHS-EAATIAEWKDGLNEMWADLLELIDT--------RMQLLAAS 1796
+ I+ L+ +GH A E K + + +L+ DT +QL A
Sbjct: 3832 -ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 3890
Query: 1797 YDLHRYFYTGAEILGLIDEKH---RELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
+++++ T E+ + E +LP L+ T H + +
Sbjct: 3891 SLVNQFWETYEELWPWLTETQSIISQLPAP-ALEYETLRQQQEEHRQLRELIAEHKPHID 3949
Query: 1854 QFQDVATRLQTAYAGE---------KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD 1904
+ +L GE A+ + ++ +E LD + TQ D D
Sbjct: 3950 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4009
Query: 1905 KFRFFSMARDLLSWMESIIRQIETQERPRDVSS----VELLMKYHQGINAEIETRSKNFS 1960
+ +ES+ R +E +P +S+ ++ + ++ ++ ++E +
Sbjct: 4010 QI------------LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYE 4057
Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
+ GE ++ R ++I K Q + ++ WE + L+E R+A +
Sbjct: 4058 TLKQRGEEMIARSGGTDKDISAKAVQ------DKLDQMVFIWENIHTLVE----EREAKL 4107
Query: 2021 AEAWLIAQE 2029
+ +A++
Sbjct: 4108 LDVMELAEK 4116
Score = 94.7 bits (234), Expect = 8e-19
Identities = 157/754 (20%), Positives = 293/754 (38%), Gaps = 78/754 (10%)
Query: 307 YSGLASDLLTWIEQTIT-VLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
+ G DL W+ T +L S+ ++QL +E F+ K
Sbjct: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH-----MEVCAAFEAKEETYKS 4499
Query: 366 LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLAR 425
L +M A K + + ++++ WES+E R+ L L LA
Sbjct: 4500 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL-------NLAM 4552
Query: 426 RFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDL 484
F WL++ Q L L V +H+ + ++ E++ L+
Sbjct: 4553 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4612
Query: 485 AQELEKENYHDQKRITARKDNIL----RLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
L+ Y QK+ N+L W + + L R + L+ K F +
Sbjct: 4613 GTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4669
Query: 541 I-DWMDEIKAHLLSA-EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGK 598
+ +W++E + L S E +++ L +HK + + + V T T + + K
Sbjct: 4670 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK-HSVYDTTNRTGRSLKEK 4728
Query: 599 GYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAE-SWIKEKE 657
D + D +S L ++ + + R+ +LE++ F + +A W+ E
Sbjct: 4729 TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4788
Query: 658 -QIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEA 716
Q+ D+ V+ L HKAF+ EL + ++ + + A ++ + ++
Sbjct: 4789 PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV 4848
Query: 717 RIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHRLLSGEDV-GQD 774
+++E+S +W+ + L+ + L+ A +F L WL +A + L V D
Sbjct: 4849 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 4908
Query: 775 EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD----VTHRLQALRELY 830
E A R L +HK+F+++LEE R + + G PD + H + +R +
Sbjct: 4909 EDALRTLIDQHKEFMKKLEEKRAELN--KATTMGDTVLAICHPDSITTIKHWITIIRARF 4966
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME---MPDTLEDLEVV 886
++V+A A QQRL AL E +A W+ E L + + +P +E+++ +
Sbjct: 4967 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5026
Query: 887 QHRFDILDQEMKTLMTQIDGVN-----------------------------LAANSLVES 917
+EM +D V A+SL S
Sbjct: 5027 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5086
Query: 918 GHPRSREVKQYQDHLN-TRWQAFQTLVSERREAVDSAL-------RVHNYCVDC--EETS 967
G E K + +L ++WQ L ERR ++ AL N+ D ++
Sbjct: 5087 GSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYM 5146
Query: 968 KWIT-DKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
+W+ K++V++ + + +D G I Q + G+
Sbjct: 5147 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5180
Score = 62.8 bits (151), Expect = 4e-09
Identities = 59/292 (20%), Positives = 127/292 (43%), Gaps = 27/292 (9%)
Query: 515 ELLQSRRQRLETTLALQKLFQDMLHS------IDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
+L+Q R+ L+++L Q L ++ ++ ++W+DE++ L E+G L VE L+
Sbjct: 620 KLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE 679
Query: 569 KHK-----LMEADIAIQGDKVKAIT-AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEEL 622
HK + E + +++ K+ I A LK T +++ LE + +L
Sbjct: 680 NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA------------EKLHRLESQYAKL 727
Query: 623 SNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF 682
N + ++ L+ L F W+ EKE+ + D+ + T++ + H
Sbjct: 728 LNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL 784
Query: 683 EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
EL + +++ + + A ++ IEA + QW + L ++++++
Sbjct: 785 MRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN 844
Query: 743 ENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEE 794
+F+F DA + +L++ + + + L ++ +EE EE
Sbjct: 845 TAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 896
Score = 59.7 bits (143), Expect = 3e-08
Identities = 68/313 (21%), Positives = 135/313 (43%), Gaps = 39/313 (12%)
Query: 293 VIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEK 352
++D + E++ K+ DLL W+++ L+ ++ + L V+ L+ ++ V +
Sbjct: 633 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE---NHKNVHR 686
Query: 353 PPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRN 412
+ E E + IQ M A + Y +L E++Y + L N
Sbjct: 687 AIEEFESSLKEAKISEIQ--MTAPLKLTYAEKLHRL------------ESQYAK---LLN 729
Query: 413 ELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA--VEAAKKK--HEAIE 468
QE+ F +A WL+E + ++ YD + A+KK H +
Sbjct: 730 TSRNQERHLDTLHNFVSRATNELIWLNEKE----EEEVAYDWSERNTNIARKKDYHAELM 785
Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
+ EE +++++++A++L EN+ + I A + + WS++ +L Q Q ++
Sbjct: 786 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 845
Query: 529 ALQKLFQDMLHSIDWMDEIKAHL---LSAEFGKHLLEVEDLLQ-----KHKLMEADIAIQ 580
A + F D + D++ +K + S + + ++EDL+Q K +L++ I
Sbjct: 846 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 905
Query: 581 GDKVKAITAATLK 593
KA T LK
Sbjct: 906 NLMGKAKTIIQLK 918
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/248 (19%), Positives = 103/248 (41%), Gaps = 11/248 (4%)
Query: 1599 WIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL-ASRAQGLLSAGHPE 1657
W+ E ++ + E D L+ H RA+E++ ++K+ S Q
Sbjct: 654 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTY 713
Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
E++ RL+ Q YA L + + ++R L+ +++ + R T++L W++EKE + +
Sbjct: 714 AEKLHRLESQ----YAKLLNTSRNQERHLDTLHNF--VSRATNEL-IWLNEKEEEEVAYD 766
Query: 1718 MGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNE 1777
+ ++ +D + RE +E + +V E+L+ H TI ++ +
Sbjct: 767 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 825
Query: 1778 MWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRV 1837
W+ +L+L Q + + +F E + + D S+ S H++
Sbjct: 826 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS--SIHKL 883
Query: 1838 HTAFEREL 1845
+ +
Sbjct: 884 EDLVQESM 891
Score = 51.2 bits (121), Expect = 1e-05
Identities = 147/816 (18%), Positives = 311/816 (38%), Gaps = 106/816 (12%)
Query: 1249 VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNL 1308
+Q +E RK E E S L L Q L + E+ K+ Q + + +
Sbjct: 1346 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATV 1402
Query: 1309 HNKWLKHQAFVAELASHEG-------WLENIDAEGKQLMDEKPQFTALVSQKLE------ 1355
+ L+ + A + S + + D ++ MD + ++TALV+ +
Sbjct: 1403 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1462
Query: 1356 -ALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLR-SDDPGKDLTS 1413
+L RL +E ++ +EK +H+ A+ +L KW+S + L+ ++ GK S
Sbjct: 1463 DSLKRLEEEEKSLEEEKKEHVEKAK----------ELQKWVSNISKTLKDAEKAGKPPFS 1512
Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
K K ++++ +KE+L E + + GD E+ L+ +
Sbjct: 1513 ------KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1566
Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH--- 1530
L S + Q+ + VEE++ + +Y LQ + + + +N ++GH
Sbjct: 1567 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQT---ENRLIGHQEA 1623
Query: 1531 ------TPRVEDVLQRGQQLVEAAEIDCQDLEERL----GHLQSSWDRL-REAAAGRLQR 1579
T ++ + ++L + + Q L E + L+ + ++L +E A Q+
Sbjct: 1624 FMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQK 1683
Query: 1580 LRDAN-EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR 1638
L +A + +Q L A++++ + + I +E K A+ L+ + + D+
Sbjct: 1684 LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK--VAAVKQLEESKTKIENLLDWLS 1741
Query: 1639 NIKQLASRA---------QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
N+ + + RA Q +G+ I + +V+ + DV + EN+
Sbjct: 1742 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-TDVDGQVGTTQENL 1800
Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
+Q + E+ IS+ + V + + Q LL + + + E Q+ +
Sbjct: 1801 NQQYQKVKAQH--EKIISQHQAVIIATQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKE 1853
Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ E + + ++ L + AD E L + +L +I
Sbjct: 1854 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF---EHWLQQSEQELENLEAGADDI 1910
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869
GL+ + R+ +SF + + +L + + + + A G+
Sbjct: 1911 NGLMTKLKRQ------------KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 1958
Query: 1870 -----KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR-DLLSWMESII 1923
+Q K + +++L C L D DK++ + A LL+ +++
Sbjct: 1959 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2018
Query: 1924 R----------QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
++ + R + + L +E K L+ SLL
Sbjct: 2019 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL--- 2075
Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLL 2009
A +I++ L ++ R +++++ R E+L++ L
Sbjct: 2076 -PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2110
Score = 50.4 bits (119), Expect = 2e-05
Identities = 136/759 (17%), Positives = 292/759 (38%), Gaps = 123/759 (16%)
Query: 964 EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
++ W+ D+ +V + G DL + + + R + ++ + E + ++
Sbjct: 649 QDLLNWV-DEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK--EAKISEIQM 705
Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
+ P K ++ LE + L + + QE L L F+ + WL+ ++
Sbjct: 706 TAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEE 761
Query: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
+ D E + HA + E+D +++ + V+E E+++ + P L +
Sbjct: 762 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL-ENHPARLTIEAYR 820
Query: 1144 EGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAA 1203
+ T W+ + ++ + + + + EF DAK+A L N + + D
Sbjct: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCD----R 876
Query: 1204 EAGIRKFEDFLGSMENNRDKVLS-------------------------PVDSGNKLVA-- 1236
+ I K ED + ++++L P+ + + A
Sbjct: 877 SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAIC 936
Query: 1237 -----EGNLYSDKIKEKVQLIEDRHR-------KNNEKAQEASVLL------RDNLELQN 1278
E +Y D ++ L + HR +A SV ++ ++L N
Sbjct: 937 DYRQIEITIYKD---DECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN 993
Query: 1279 FLQNCQE--LTLW----INDKLLTSQDVSYDEARNLHNKWL---------KHQAFVAELA 1323
++ + LTLW IN K + S +E + + +HQ ++ L
Sbjct: 994 RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQ 1053
Query: 1324 SH-EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ-------HL 1375
S E +LE D++ Q+ + +++ + + EL + + + Q ++
Sbjct: 1054 SRFEDFLE--DSQESQVFSGSD--ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI 1109
Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKD---LTSVNRMLAKLKRVEDQVNVRK 1432
S R+ LRL+ D + I + L DD + +T ++ +L+R++D +
Sbjct: 1110 SEVRNIRLRLENCED--RLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 1167
Query: 1433 EELGELFAQ------VPSMGEE------GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480
+ E F+Q VP++ E + S+ ++D L+ + K +++ A
Sbjct: 1168 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1227
Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
+++ ET EE +A N++ + +K+ ++ +E +ED LQ+
Sbjct: 1228 VKLY-----ETKLCEEEAVIADK----NNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1278
Query: 1541 GQQL-------VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
+ + + ++D +E+ L W + RL+ L ++ +YY D
Sbjct: 1279 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1338
Query: 1594 -DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQR 1631
+ WI Q++ +I +++ L L QQ+
Sbjct: 1339 YHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQK 1375
Score = 35.4 bits (80), Expect = 0.60
Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 9/224 (4%)
Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV-----EDQVNVRKEELG 1436
++ ++ DL W+ M+ QL + G DL SV L K V E + ++++ ++
Sbjct: 642 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 701
Query: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEE 1496
E+ P + + +E ++ LL +++ L++ +SR +E +W+ E
Sbjct: 702 EIQMTAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN--FVSR-ATNELIWLNE 757
Query: 1497 RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLE 1556
+ + D+ + + L E+ ++ V + +QL+ +E
Sbjct: 758 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 817
Query: 1557 ERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
+Q+ W + + Q +++ +++ DA EA ++
Sbjct: 818 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 861
Score = 33.9 bits (76), Expect = 1.8
Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 32/212 (15%)
Query: 1808 EILGLIDEKHRELPE-----DVGLDASTAESFHRVHTAFER-ELHLLGVQVQQFQDVATR 1861
++L +DE +L D+ S E+ VH A E E L ++ + Q A
Sbjct: 650 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP- 708
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L+ YA K + + + LL+ + L DT F S A + L W+
Sbjct: 709 LKLTYA--------EKLHRLESQYAKLLNTSRNQERHL-DTLHNF--VSRATNELIWLNE 757
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ + +++ YH + E++ + +N + E+ E LL H A I
Sbjct: 758 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 817
Query: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
+ R M +W W +L++CQ
Sbjct: 818 -------AYRAAMQTQWS--W-----ILQLCQ 835
Score = 32.0 bits (71), Expect = 6.7
Identities = 47/286 (16%), Positives = 105/286 (36%), Gaps = 20/286 (6%)
Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
DL W+ E ++ E G D V + ++ R + F L +A
Sbjct: 650 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA-----------IEEFESSLKEA 698
Query: 1761 GHSEAATIAEWK----DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGA-EILGLIDE 1815
SE A K + L+ + + +L++T LH + E++ L ++
Sbjct: 699 KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 758
Query: 1816 KHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQ 1875
+ E+ D + H REL ++ Q++A +L + I+
Sbjct: 759 EEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL-TIE 817
Query: 1876 NKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQ---ERP 1932
+ W +L C + + F FF+ A++ ++ ++ I+ + +R
Sbjct: 818 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS 877
Query: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASE 1978
+ +E L++ E+ + + ++++Q + + S+
Sbjct: 878 SSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 923
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 298 bits (763), Expect = 4e-80
Identities = 172/388 (44%), Positives = 234/388 (60%), Gaps = 15/388 (3%)
Query: 48 LADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGK 107
+ADER+ VQKKTFTKW+N HL +V + DLY+DLRDG LI LLEVLSG+ LP+ KG+
Sbjct: 207 IADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPRE-KGR 265
Query: 108 MRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ 167
MR H L+NV AL +LK ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V +
Sbjct: 266 MRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 325
Query: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKD 227
E SAK+ LLLW Q T GY + NFT+ W+DG FNA+IHK+RPDLID + +
Sbjct: 326 S--EDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAV 383
Query: 228 SNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEG 287
+ NLEHAF VAE+ +G+I LLDPEDV +PDEKS+ITYV + Y F K + G
Sbjct: 384 QSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK---VPEGG 439
Query: 288 KRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTY 347
+ +G A + E +Y + + L+ WI +T ++ R F N+ ++ + +
Sbjct: 440 EGIG-----ANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQF 494
Query: 348 RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRE 407
+ E PPK EK ++ L ++ + K+ G +DI + W L A RE
Sbjct: 495 KETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLERE 551
Query: 408 LALRNELIRQEKLEQLARRFDRKAAMRE 435
ALR E+ R E L+Q+A R R + + E
Sbjct: 552 KALRPEVERLEMLQQIANRVQRDSVICE 579
Score = 171 bits (432), Expect = 9e-42
Identities = 321/1659 (19%), Positives = 676/1659 (40%), Gaps = 141/1659 (8%)
Query: 387 KLVSDINRAWESL-EEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSE-NQRL 444
K +S ++ WE+L +AE R + E + +A++F WL+ +RL
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNR--------QLEGISVVAQQFHETLEPLNEWLTTIEKRL 3616
Query: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504
V + G + +E +H+A+E D + + + + Q L+ + + K + K
Sbjct: 3617 VNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKL 3676
Query: 505 NILRLWSY-LQELLQSRRQRLETTLALQKLF-QDMLHSIDWMDEIKAHLLSAEFGKHLLE 562
+ ++W +QE SR + L+ L K+F +D + ++W++E+ L + E
Sbjct: 3677 DFSQVWYIEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTE 3736
Query: 563 VEDLLQKH-KLMEADIAIQGDKVKAITA---ATLKFTEGKGYQPCDPQVIQDRISHLEQC 618
Q ++++ DI ++ V LK T G + +IQD++ ++
Sbjct: 3737 GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGD-----EVLIIQDKLEAIKAR 3791
Query: 619 FEELSNMAAGRKAQLEQSKRLWKFFWEM-DEAESWIKEKEQIYSSLDY----GKDLTSVL 673
+++++ ++ LEQ+ +L + +E +W+ + E S + G++ +
Sbjct: 3792 YKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA- 3850
Query: 674 ILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQF-GHPQIEARIKEVSAQWDQLKDLA 732
Q + K + E + A L+ + + + ++ + +E + E + ++ + D
Sbjct: 3851 --QMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTI 3908
Query: 733 AFCKKNLQDAE-NFFQFQGDADDLKAWLQDAHR-LLSGEDVGQDEGATRALGKKHKDFLE 790
+ + A QF AD +W+ + + L+S D+ ++ T A + K F
Sbjct: 3909 TQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTM 3968
Query: 791 ELEESRGVMEHLEQQAQGF----PEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQE 846
E+ + +++ L + EE + S + +L + + Y + R +L+
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACSEEEKQS--MKKKLDKVLKNYDTICQINSERYLQLER 4026
Query: 847 ALDLYTVFGET-DACELWMGEKEKWLAEMEMPDT-LEDLEVVQHRFDILDQEMKTLMTQI 904
A L F ET + W+ E + ++++ P E L Q L + + I
Sbjct: 4027 AQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHI 4086
Query: 905 DGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCE 964
D +N L+E +++ +T + + V +R A+D A+ D
Sbjct: 4087 DKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHD-- 4144
Query: 965 ETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLS---GLERDVAAIQARVDALERESQQL 1021
+ + + ++VE + A + I+ ++S + D+ +Q + L++ +++
Sbjct: 4145 KIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204
Query: 1022 MDSHPEQKEDIGQR--QKHLEEL---WQGLQQSLQGQEDLLGEVSQL-QAFLQDLDDFQA 1075
+ +DI + Q L+++ W+ + ++ +E L +V +L + F D
Sbjct: 4205 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4264
Query: 1076 WLSITQKAVASEDMPESLPEAEQLLQQHAG-IKDEIDGHQDSYQRVKESGEKVIQGQTDP 1134
+ TQ + + P P + Q+ A I++EIDG Q+ V G ++I +P
Sbjct: 4265 TIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEP 4324
Query: 1135 EYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAE-AILSNQEYTLAH 1193
+ ++ + ++ L++ W++L + W+ R L + + +D QA + LA
Sbjct: 4325 DKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLAS 4384
Query: 1194 LEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDK-------- 1244
+ P LE + I + + F + ++ L+ + SDK
Sbjct: 4385 MSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLM 4444
Query: 1245 -IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWI--NDKLLTSQDVS 1301
+K +E+R K + A L L F EL W+ + LL+ Q
Sbjct: 4445 ELKLIWDSLEERIINRQHKLEGAL------LALGQFQHALDELLAWLTHTEGLLSEQKPV 4498
Query: 1302 YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKP-QFTALVSQKLEALHRL 1360
+ + + + KH ++ +H+ +E ++ G L++ + + + KLE L++
Sbjct: 4499 GGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQR 4558
Query: 1361 WDELQATTKEKTQHLSAA-RSSDLRLQTHADLNKWISAMEDQLRSDDP-------GKDLT 1412
W + T+++ Q L A R + DL +W++ E L + P K+
Sbjct: 4559 WQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL 4618
Query: 1413 SVN-RMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADL-SIEKRFLDLLEPLGRR 1470
+V+ + A + E+ ++ ++ A+ P E D D+ ++++++ + L R
Sbjct: 4619 NVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNER 4678
Query: 1471 KKQLESS-RAKLQISRDLEDETLWV---EERLPLAQSADYGTNLQTVQLFMKKNQTLQNE 1526
K +LE + ++ L+D W+ E+ L +A L TV + +++ NE
Sbjct: 4679 KTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP--SLILDTVLFQIDEHKVFANE 4736
Query: 1527 ILGHTPRVEDVLQRGQQL-VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE 1585
+ H ++ ++ + G L + + D ++ L +QS W+++ + R + L DA +
Sbjct: 4737 VNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARK 4796
Query: 1586 -AQQYYLDADEAEAWIGEQELYVISD-EIPKDEEGAIVMLKRHLRQQRAV---------- 1633
A+Q++ + W+ E E + S+ EI D + L +H Q+++
Sbjct: 4797 RAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTT 4856
Query: 1634 EDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLF 1693
GR++K+ S A L + + L+ + D + + ER+ KLE L
Sbjct: 4857 NRTGRSLKEKTSLADDNLKL----DDMLSELRDKWDT----ICGKSVERQNKLEEA--LL 4906
Query: 1694 QLKRETDDLEQWIS-----EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVD 1748
+ TD L+ I E +L P G D D V L D + F +E G +R
Sbjct: 4907 FSGQFTDALQALIDWLYRVEPQLAEDQPVHG-DIDLVMNLIDNHKAFQKELG----KRTS 4961
Query: 1749 NVNAF---IERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASY----DLHR 1801
+V A LI+ +++ + L+ W + L ++ L A+ + H
Sbjct: 4962 SVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHS 5021
Query: 1802 YFYTGAEILGLIDEK---HRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDV 1858
+ E L ++ H LP+ D + H F ++L ++ + +
Sbjct: 5022 VVHALLEWLAEAEQTLRFHGVLPD----DEDALRTLIDQHKEFMKKLEEKRAELNKATTM 5077
Query: 1859 ATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTA-----DKFRFFSMAR 1913
+ + I++ + A ++ +L A A + Q + +A K
Sbjct: 5078 GDTVLAICHPDSITTIKHWITIIRARFEEVL-AWAKQHQQRLASALAGLIAKQELLEALL 5136
Query: 1914 DLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEI 1952
L W E+ + + + P+++ V+ L+ HQ E+
Sbjct: 5137 AWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175
Score = 157 bits (397), Expect = 1e-37
Identities = 322/1813 (17%), Positives = 717/1813 (39%), Gaps = 209/1813 (11%)
Query: 389 VSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQD 448
++ I W++ + RE L+ L + A ++ + W+ + Q + +
Sbjct: 3021 LNTIKTNWDTFNKQVKERENKLKESL-------EKALKYKEQVETLWPWIDKCQNNLEEI 3073
Query: 449 NFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILR 508
F D A E + K ++++ + + V L + A L D++ +T ++++
Sbjct: 3074 KFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQ 3133
Query: 509 LWSYLQELLQSRRQRLETTLALQKLFQDML-----------HSIDWMDEIKAHLLSAEFG 557
+ E L S++ LE K FQ++ +D D + + S ++
Sbjct: 3134 KVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYL 3193
Query: 558 KHLLEVEDLLQ--KH-----KLMEADIAIQGDKVKAITAATLKF-TEGKGYQPCDPQV-- 607
L + LQ KH K + D+ ++ K + L+ T + + QV
Sbjct: 3194 TMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDE 3253
Query: 608 ------------------IQDRISHLEQCFEELSNMA-AGRKAQLEQSKRLWKFFWEMDE 648
I++ S + +EL +MA GR A+ Q ++ +
Sbjct: 3254 KCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQK--------ET 3305
Query: 649 AESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQ 708
++++K+ E + +S D +++ + +L G+ LE + ++ + ++ R Q
Sbjct: 3306 IKAFLKKLEALMASNDNANKTCKMMLATEETSP---DLVGIKRDLEALSKQCNKLLDRAQ 3362
Query: 709 FGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG 768
Q+E IK + + +LK+ + LQ AE + QG +
Sbjct: 3363 AREEQVEGTIKRLEEFYSKLKEFSIL----LQKAEEHEESQGPVG------------MET 3406
Query: 769 EDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD---VTHRLQA 825
E + Q + K EE+E +G + + QG + S + H L
Sbjct: 3407 ETINQQLNMFKVFQK------EEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDD 3460
Query: 826 LRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEMEMPDTLEDLE 884
+ ++ + + R +LQEAL F + ++ WM + E+ +A + P + +
Sbjct: 3461 VNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSA--EFK 3518
Query: 885 VVQHRFD---ILDQEMKTLMTQIDGVNLAANSLVESGHPRSR-EVKQYQDHLNTRWQAFQ 940
VV+ + +L + + + ++ + + + P + ++ + L++RW+A
Sbjct: 3519 VVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALL 3578
Query: 941 TLVSERREAVDS-ALRVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSG 999
R ++ ++ + E ++W+T K + + + +G + + +
Sbjct: 3579 NKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKA 3638
Query: 1000 LERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQKHLEELWQ-GLQQSLQGQEDLLG 1058
LE D+ + Q L + +D+ Q + ++W +Q+ + +LL
Sbjct: 3639 LEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQ 3698
Query: 1059 E-VSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGI-KDEIDGHQDS 1116
+ + + F +D + WL+ ++ + + E Q + +++I + +
Sbjct: 3699 QALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQN 3758
Query: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQ---------- 1166
+ +G ++++ T E L++ +LE + + + ++ + TL Q
Sbjct: 3759 VDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHS 3818
Query: 1167 -----CLGFQEFQKDAKQAEA-ILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENN 1220
C + + + E +L +E + A + P + + A + + L S+
Sbjct: 3819 THEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA----KNNKALLDSLNEV 3874
Query: 1221 RDKVLSPV-----DSGNKLVAEGN----LYSDKIKEKVQLIEDRHRKNNEKAQEASVLLR 1271
+L V + K+VAE N L SD I +KV+ I+ + +LR
Sbjct: 3875 SSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEID-------------AAILR 3921
Query: 1272 DNLELQNFLQNCQELTLWIND---KLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGW 1328
Q F Q WI + KL++ D+ ++ + ++ + F E+ H+
Sbjct: 3922 S----QQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQ-KTFTMEILRHKDI 3976
Query: 1329 LENIDAEGKQLM----DEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLR 1384
++++ G ++M +E+ Q + +KL+ + + +D + E+ L A+S +
Sbjct: 3977 IDDLVKSGHKIMTACSEEEKQ---SMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQ 4033
Query: 1385 L-QTHADLNKWISAMEDQL-RSDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQV 1442
+T+ +L W++ + + + P + ++ + + +++ + + K + ++
Sbjct: 4034 FWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTG 4093
Query: 1443 PSMGEEGGDADLSIEKRFL-------DLLEPLGRRKKQLESSRAKLQISRDLEDETLWVE 1495
P + E SI+++++ + E + +R L+ + ++ D D+ L
Sbjct: 4094 PQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESL 4153
Query: 1496 ERL--PLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA----- 1548
ER+ L Q ++ ++ + +N+ + ++ P E + QRG++++ +
Sbjct: 4154 ERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTDK 4213
Query: 1549 EIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANE-AQQYYLDADEAEAWIGEQELYV 1607
+I + ++++L + W+ + R +L D E A++++ D I + + ++
Sbjct: 4214 DISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFI 4273
Query: 1608 ISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASR--------AQGLLSAGHPEGE 1659
E P + + +QQ A E I L ++ + + G P+
Sbjct: 4274 RDLEDPGIDPSVV------KQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKP 4327
Query: 1660 QIIRLQGQVDKHYAGLKDVAEERKRKLEN-MYHLFQLKRETDDLEQW--ISEKELVASSP 1716
+ + +++ + L ++R KLE M Q + + W I+ +L + SP
Sbjct: 4328 IVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSP 4387
Query: 1717 EMGQDFDHVTLLRDKFRDFARET--GAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDG 1774
+G D + V ++ + F E I ER+++ + + + S+ T+ +
Sbjct: 4388 -IGTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKV-TEESDKHTVQDPLME 4445
Query: 1775 LNEMWADLLE-LIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPED--VGLDASTA 1831
L +W L E +I+ + +L A L ++ + E+L + L E VG D
Sbjct: 4446 LKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505
Query: 1832 ESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDA 1891
E H + ++ V+ L + AGE+A +QNK + ++ WQ +L+
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEK 4565
Query: 1892 CAGRRTQLVDTADKFR-FFSMARDLLSWMESIIRQIETQERPRDV-SSVELLMKYHQGIN 1949
R+ QL + + F DL W+ R + + + + + + H +
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVC 4625
Query: 1950 AEIETRSKNFSACLELGESLLQRQHQASE--------EIREKLQQVMSRRKEMNEKWEAR 2001
A E + + + + ++ G+ +L R +++E ++EK + V ++ E K E
Sbjct: 4626 AAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLE-- 4683
Query: 2002 WERLRMLLEVCQFSRDASVAEAWLIAQEPYL-ASGDFGHTVDSVEKLIKRHEAFEKSTAS 2060
E L + +E F WL E L + +D+V I H+ F S
Sbjct: 4684 -EALNLAME---FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNS 4739
Query: 2061 WAERFAALEKPTT 2073
E+ L+K T
Sbjct: 4740 HREQIIELDKTGT 4752
Score = 155 bits (393), Expect = 3e-37
Identities = 308/1553 (19%), Positives = 632/1553 (40%), Gaps = 124/1553 (7%)
Query: 606 QVIQDRISHLEQCFEELSNMAAGRKAQLEQSK-RLWKFFWEMDEAESWIKEKEQIYSSLD 664
Q ++ + + ++ L+ A R AQL+++ +F ++ SW+ + E++ ++
Sbjct: 3452 QGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQK 3511
Query: 665 YGKDLTSVLILQ-RKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHP-QIEARIKEVS 722
V+ Q ++ K + L + +E I +E + + +I ++ +
Sbjct: 3512 PPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLD 3571
Query: 723 AQWDQLKDLAAFCKKNLQDAENFFQ-FQGDADDLKAWLQDAH-RLLSGEDVGQDEGATRA 780
++W+ L + A + L+ Q F + L WL RL++ E +G
Sbjct: 3572 SRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEE 3631
Query: 781 LGKKHKDFLEELEESRGVMEHLEQ-----QAQGFPEEFRDSPDVTHRLQALRELYQQVVA 835
+HK +++ +HL Q Q+ D V +L + Y ++
Sbjct: 3632 QIAQHKALEDDIINHN---KHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQE 3688
Query: 836 QADLRQQRLQEALDLYTVFGETDACEL--WMGEKEKWLAEMEMPD-TLEDLEVVQHRFDI 892
++ R + LQ+AL +FGE D EL W+ E L+++ + D + E L Q +
Sbjct: 3689 KSHSRSELLQQALCNAKIFGE-DEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRV 3747
Query: 893 LDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNT---RWQAFQTLVSERREA 949
L +++ +D L L++ EV QD L R++ L ++ +
Sbjct: 3748 LQEDILLRKQNVDQALLNGLELLKQ--TTGDEVLIIQDKLEAIKARYKDITKLSTDVAKT 3805
Query: 950 VDSAL----RVHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKL--SGLERD 1003
++ AL R+H+ EE W+ DK +V E + L G A Q ++ L+++
Sbjct: 3806 LEQALQLARRLHS---THEELCTWL-DKVEV-ELLSYETQVLKGEEASQAQMRPKELKKE 3860
Query: 1004 VAAIQARVDALERESQQLMDSHP-EQKEDIGQRQKHLEELWQGLQQSL-QGQEDLLGEVS 1061
+A +D+L S L++ P +E + + E ++ + ++ Q E++ +
Sbjct: 3861 AKNNKALLDSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAIL 3920
Query: 1062 QLQAFLQDLDDFQAWLSITQKAVAS-EDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRV 1120
+ Q F Q D +W++ T+K + S D+ + LQ EI H+D +
Sbjct: 3921 RSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILRHKDIIDDL 3980
Query: 1121 KESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGF-QEFQKDAKQ 1179
+SG K++ ++ E + ++L+ + ++ + ++ R L + +F + ++
Sbjct: 3981 VKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEE 4040
Query: 1180 AEAILSNQEYTLAHLEPP----DSLEAAEAGIRKFEDFLGSMENNRDKV---------LS 1226
L+ + ++ L P ++L + R+ + + + + DK+ LS
Sbjct: 4041 LWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLELS 4100
Query: 1227 PVDSGN---KLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNC 1283
P + + K VA LYS +IKE V+ ++A + + + + +
Sbjct: 4101 PGEGFSIQEKYVAADTLYS-QIKEDVK----------KRAVALDEAISQSTQFHDKIDQI 4149
Query: 1284 QELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLM--- 1340
E I ++L +S E + + +++ ++ + E + G++++
Sbjct: 4150 LESLERIVERLRQPPSISA-EVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARS 4208
Query: 1341 --DEKPQFTALVSQKLEALHRLWDELQATTKEK-TQHLSAARSSDLRLQTHADLNKWISA 1397
+K V KL+ + +W+ + +E+ + L ++ H L I
Sbjct: 4209 GGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKD 4268
Query: 1398 MEDQLRS-DDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSI 1456
+D +R +DPG D + V + + + ++++ +EEL + + G+ D I
Sbjct: 4269 TQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPI 4328
Query: 1457 EKRFLDLLEPL---------GRRKKQLESSRAKLQISRDLEDETLWVE-ERLPLAQSADY 1506
K+ +D L R K E+ +A +Q L+ WV+ LA +
Sbjct: 4329 VKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPI 4388
Query: 1507 GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQS 1564
GT+L+TV+ +++ + ++E +E + + + L++ E D +++ L L+
Sbjct: 4389 GTDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448
Query: 1565 SWDRLREAAAGRLQRLRDANEAQQYYLDA-DEAEAWIGEQELYVISDEIPK--DEEGAIV 1621
WD L E R +L A A + A DE AW+ E ++S++ P D + +
Sbjct: 4449 IWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTE-GLLSEQKPVGGDPKAIEI 4507
Query: 1622 MLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVD---KHYAGLKDV 1678
L +H Q V + ++ + L+ + GE+ LQ +++ + + + +
Sbjct: 4508 ELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESS--AGEEASNLQNKLEVLNQRWQNVLEK 4565
Query: 1679 AEERKRKLENMYHLFQ-LKRETDDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDF 1735
E+RK++L+ + E +DL+QW++ E+ L+AS P G L +
Sbjct: 4566 TEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQL-----NV 4620
Query: 1736 ARETGAIGQERVDNVNAFIER----LIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQ 1791
E A + + + + +++ L S I + + L E W + ++ R
Sbjct: 4621 HMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4680
Query: 1792 LLAASYDLHRYFYTGAE-ILGLIDEKHREL--PEDVGLDASTAESFHRVHTAFERELHLL 1848
L + +L F+ + + + + + L L T H F E++
Sbjct: 4681 KLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSH 4740
Query: 1849 GVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRF 1908
Q+ + T L+ + I+N V + W+ ++ R L D + +
Sbjct: 4741 REQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQ 4800
Query: 1909 FSMA-RDLLSWMESIIRQIETQ-ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELG 1966
F A L+ W+E + ++++ E D ++ + H+ + + + G
Sbjct: 4801 FHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTG 4860
Query: 1967 ESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEA----RWERLRMLLEVCQFSRDASVAE 2022
SL ++ A + + KL ++S E+ +KW+ ER L E FS + A
Sbjct: 4861 RSLKEKTSLADDNL--KLDDMLS---ELRDKWDTICGKSVERQNKLEEALLFSGQFTDAL 4915
Query: 2023 A----WLIAQEPYLASGDFGH-TVDSVEKLIKRHEAFEKSTASWAERFAALEK 2070
WL EP LA H +D V LI H+AF+K AL++
Sbjct: 4916 QALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968
Score = 149 bits (375), Expect = 4e-35
Identities = 358/1838 (19%), Positives = 731/1838 (39%), Gaps = 212/1838 (11%)
Query: 359 KGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE 418
K EVLL S + A N T D +V +S+ E + ++ L L Q+
Sbjct: 2199 KKTAEVLLDARGSLLPAKNDIQKTLDD--IVGRYEDLSKSVNERNEKLQITLTRSLSVQD 2256
Query: 419 KLEQLARRFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEER 477
L+++ W+ L Q + A++ K+ +E D A +
Sbjct: 2257 GLDEML-----------DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSS 2305
Query: 478 VRALEDLAQE-LEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQD 536
+ A+ + ++ +E + + A+ ++ +S + ++E +LF++
Sbjct: 2306 INAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFEN 2365
Query: 537 MLHSIDWMDEIKAHLLSAEF--GKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKF 594
+ + E K L+ GK + E+ +Q+ ++ K + + LK
Sbjct: 2366 LSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQE----STSEFLEHKKHLEVLHSLLKE 2421
Query: 595 TEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQ-SKRLWKFFWEMDEAESWI 653
G P D ++ ++ ++L + F+E+ + +K + ++L F + +SWI
Sbjct: 2422 ISSHGL-PSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWI 2480
Query: 654 KEK-------EQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH-------LEQIFQE 699
KE + + + D GK L LQ K E++ ++ + +
Sbjct: 2481 KETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTP 2540
Query: 700 AHGMVARKQFGH--------------------PQIEARIKEVSAQWDQL----KDLAAFC 735
A + A K G I+ + ++S ++ L KD A
Sbjct: 2541 AKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAEL 2600
Query: 736 KKNLQDAENFFQFQGDADDLKAWLQDAHRLLSG---EDVGQDEGATRALGKKHKDFLEEL 792
L + + Q ++ + WLQ ++ + D A + +++K F EL
Sbjct: 2601 NTKLSKLQ---KAQEESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAEL 2657
Query: 793 EESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALD 849
+++ ++ L+ + EE D+P+ Q L E+ +Q++ RQQ+L+E+ +
Sbjct: 2658 KQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSN 2717
Query: 850 LYTVFGETDA-CELWMGEKEKWLAEMEMPDTLED--LEVVQHRFDILDQEMKTLMTQIDG 906
T F +A + W+ EKE ++ + P +++ L + + IL QE T Q +
Sbjct: 2718 NLTQFQTVEAQLKQWLVEKELMVSVLG-PLSIDPNMLNTQRQQVQILLQEFATRKPQYEQ 2776
Query: 907 VNLAANSLVES-GHPRSRE--VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDC 963
+ A ++ G S VK+ + +W + +S+R + +D A+
Sbjct: 2777 LTAAGQGILSRPGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAI--------- 2827
Query: 964 EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
+++++ + + + DL L+ +A+ + + + Q +++E +Q+
Sbjct: 2828 VKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKV 2887
Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQG--------QEDLLGEVSQLQA-------FLQ 1068
+ ED+ K E L L + L+G ++ V LQ+ F Q
Sbjct: 2888 AQA-LCEDLSALVKE-EYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQ 2945
Query: 1069 DLDDFQAWLSITQKAVASEDMPES--LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEK 1126
DFQAWL T+K ++ P S L E L++ H + Y++ GE
Sbjct: 2946 MSRDFQAWLD-TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGEN 3004
Query: 1127 VIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAI--- 1183
++ E L +L + T W+ + + R + L + L ++ K +Q E +
Sbjct: 3005 LLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESL--EKALKYKEQVETLWPW 3062
Query: 1184 -------LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSME---NNRDKVLSPVDSGNK 1233
L ++ L E +S+ ++ ++ + G +E N + +LS + +
Sbjct: 3063 IDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKE 3122
Query: 1234 LVAEGNLYSDKIKEKVQLI-EDRHRKN---NEKAQEASVLLRDNLELQNFLQNCQELTLW 1289
+V + N + +KV ++ E H K Q+ + E + LQ C + L
Sbjct: 3123 VVTDEN---KSLIQKVDMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQ-CAKEQLD 3178
Query: 1290 INDKL----LTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDEKPQ 1345
I+D L +++ ++ + + + LKHQ +A+ + + +E D++G
Sbjct: 3179 IHDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKG--------- 3229
Query: 1346 FTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQ-THADLNKWISAMEDQLRS 1404
T+ V ++E + + L EK L Q T ++ + +D+L S
Sbjct: 3230 -TSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDS 3288
Query: 1405 DDP-GKDLTSVNR----MLAKLKRVE----DQVNVRKEELGELFAQVPSMGEEGGDADL- 1454
P G+D ++ + + A LK++E N K L + S G DL
Sbjct: 3289 MAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKMMLATEETSPDLVGIKRDLE 3348
Query: 1455 SIEKRFLDLLEPLGRRKKQLESSRAKLQ--ISRDLEDETLWVEERLPLAQSADYGTNLQT 1512
++ K+ LL+ R++Q+E + +L+ S+ E L + G +T
Sbjct: 3349 ALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETET 3408
Query: 1513 VQLFMKKNQTLQ-NEILGHTPRVEDVLQRGQQLVEAA--EIDCQDLEERLGHLQSSWDRL 1569
+ + + Q EI + +DV GQ L+++A Q LE L + + W L
Sbjct: 3409 INQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLDDVNARWKTL 3468
Query: 1570 REAAAGRLQRLRDANEAQQYYLDADEA-EAWIGEQELYVISDEIPKDEEGAI-VMLKRHL 1627
+ A R +L++A + DA E+ +W+ + E V + + P E + ++
Sbjct: 3469 NKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQK 3528
Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGE-QIIRLQGQVDKHYAGLKDVAEERKRKL 1686
QR ++D ++ + + + + P + +I++ +D + L + AE R R+L
Sbjct: 3529 LLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQL 3588
Query: 1687 ENMYHLFQLKRET-DDLEQWIS--EKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIG 1743
E + + Q ET + L +W++ EK LV P + K + + A+
Sbjct: 3589 EGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP--------IGTQASKLEEQIAQHKAL- 3639
Query: 1744 QERVDNVNAFIERLIDAGHS-------EAATIAEWKDGLNEMW-ADLLELIDTRMQLLAA 1795
++ + N N + + + G S E + + K +++W ++ E +R +LL
Sbjct: 3640 EDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQ 3699
Query: 1796 SYDLHRYF-YTGAEILGLIDEKHRELPEDVGLDASTAESFHRVH--TAFERELHLLGVQV 1852
+ + F E++ ++E H +L + D ST + + + ++ L V
Sbjct: 3700 ALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNV 3759
Query: 1853 QQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-----R 1907
Q L G++ IQ+K + + A ++ + T + T ++ R
Sbjct: 3760 DQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKL----STDVAKTLEQALQLARR 3815
Query: 1908 FFSMARDLLSWMESI---IRQIETQE-RPRDVSSVELLMKYHQGINAEIETRSKNFSACL 1963
S +L +W++ + + ETQ + + S ++ K E++ +KN A L
Sbjct: 3816 LHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPK-------ELKKEAKNNKALL 3868
Query: 1964 ----ELGESLLQR-QHQASEEIREKLQQVMSRRKEMNEKWEARWERL-RMLLEVCQFSRD 2017
E+ +LL+ +A E + + + + R + +++ + E + +L QF +
Sbjct: 3869 DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQA 3928
Query: 2018 ASVAEAWLIAQEPYLAS-GDFGHTVDSVEKLIKRHEAF 2054
A +W+ E L S GD D ++ + F
Sbjct: 3929 ADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTF 3966
Score = 129 bits (325), Expect = 2e-29
Identities = 389/2030 (19%), Positives = 780/2030 (38%), Gaps = 278/2030 (13%)
Query: 277 FSKMKVLAVEGKRVGKVIDHAIETEKMIEKYSG--LASDLLTWIEQTITVLNSRK---FA 331
FSK K+ + E + + A++T ++ G + + +E+ + L F+
Sbjct: 1649 FSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFS 1708
Query: 332 NSLTGVQQQLQAFSTYRTV--------EKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTP 383
SL +QLQ T V E+ +++EK L T +Q+ +
Sbjct: 1709 ESL----KQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQTENRLIGHQEAFMI 1764
Query: 384 HDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQR 443
DG + E ++ + + EL Q+ ++ A+ E +L EN
Sbjct: 1765 GDGTV--------------ELKKYQSKQEEL--QKDMQGSAQALAEVVKNTENFLKENGE 1808
Query: 444 LVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARK 503
++Q++ + AK K E + ++ + + A + E E K++ K
Sbjct: 1809 KLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESK 1868
Query: 504 DNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLH--------SIDWMDEIKAHLLSAE 555
I L +L + + T Q + Q+ H +I DE+ +LL +
Sbjct: 1869 TKIENLLDWLSNV--DKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETD 1926
Query: 556 FGKHLLEVEDLL----QKHKLMEADIAIQGDKVKAIT--AATLKFTEGKGYQPCDPQVIQ 609
+ ++ L QK K I Q V T A L +G+ P + + +Q
Sbjct: 1927 VDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQ 1986
Query: 610 DRISHLEQCFEE-LSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYG-K 667
+ L+ +E L+ K + L KF + E E W+++ EQ +L+ G
Sbjct: 1987 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046
Query: 668 DLTSVLILQRKHKAFEDELRGLDAHLEQI------FQEAHGMVARKQFGHPQIEARIKEV 721
D+ ++ ++ K+F +++ L I EA +++ G A +EV
Sbjct: 2047 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREV 2106
Query: 722 SAQWDQLKD----LAAFCK---KNLQDAENFFQFQGDAD-DLKAWLQDAHRLLS---GED 770
+ D D L + C NL+D + +Q DA L A LQ S E
Sbjct: 2107 QRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEP 2166
Query: 771 VGQDEGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEE----FRDSPDVTHRLQAL 826
+ D + ++ K ++ + +E L++ A+ + D+ L +
Sbjct: 2167 IAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDI 2226
Query: 827 RELYQQVVAQADLRQQRLQEALD-LYTVFGETDACELWMGEKEKWLAEM-EMPDTLEDLE 884
Y+ + + R ++LQ L +V D WMG E L E ++P L+
Sbjct: 2227 VGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQ 2286
Query: 885 VVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP----------------------RS 922
+ + +L+Q++ + I+ +N +E+ P +
Sbjct: 2287 DIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKH 2346
Query: 923 REVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVV-ESTK 981
+E + L T+ + F+ L + + +++ + + + K +T+ ++ + EST
Sbjct: 2347 KETLAKMEELKTKVELFENLSEKLQTFLETKTQA---LTEVDVPGKDVTELSQYMQESTS 2403
Query: 982 DL---GRDLAGIIAIQRKLS--GLERDVAAIQARVDALERESQQLMDSHPEQKEDIGQRQ 1036
+ + L + ++ +++S GL D A + + + L ++ +++ D+ E+KE + Q
Sbjct: 2404 EFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSCQ 2463
Query: 1037 KHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096
+ L + +Q L +SL+ + + + I Q + +ED+ +SL +
Sbjct: 2464 EQL-DAFQVLVKSLKSW----------------IKETTKKVPIVQPSFGAEDLGKSLEDT 2506
Query: 1097 EQLLQQHAGIKDEIDGHQDS----------------YQRVKESGEKVIQGQ---TDPEYL 1137
++L ++ + EI +S +SG V+ G+ T+ E
Sbjct: 2507 KKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEF 2566
Query: 1138 LLGQRLEG-------LDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILS----- 1185
+ L + G+ LG + + + L L + QK +++ A++
Sbjct: 2567 WANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKL--SKLQKAQEESSAMMQWLQKM 2624
Query: 1186 NQEYTLAHLEP-PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEG--NLYS 1242
N+ T P P EA + + + + F ++ N +KV D +L+ E +
Sbjct: 2625 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2684
Query: 1243 DKIKEKVQLIEDRHRKNNEKAQEASVLLRDNL-ELQNFLQNCQELTLWINDKLLTSQ--- 1298
+ K+ + I+ + ++ N+ + L ++ L F +L W+ +K L
Sbjct: 2685 PRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELMVSVLG 2744
Query: 1299 DVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMD---EKPQFTALVSQKLE 1355
+S D L+ + + Q + E A+ + E + A G+ ++ E P +V ++L
Sbjct: 2745 PLSID-PNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLA 2803
Query: 1356 ALHRLWDELQATTKEK-----------TQHLSAARSSDLRLQTHADL-NKWISAMEDQLR 1403
A+ + WD L ++ TQ+ S RS +L +DL NK S++
Sbjct: 2804 AVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKL---SDLDNKLSSSLAVSTH 2860
Query: 1404 SDDPGKDLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLS-----IEK 1458
D + L + +M ++++ + Q+ V + +L A V EE A+LS I K
Sbjct: 2861 PDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVK---EEYLKAELSRQLEGILK 2917
Query: 1459 RFLDLLEPLGRRKKQLESSRAK----LQISRDLEDETLWVE-ERLPLAQSADYGTNLQTV 1513
F D+ + + L+S+ A Q+SRD + W++ ++ +S L +
Sbjct: 2918 SFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQ---AWLDTKKEEQNKSHPISAKLDVL 2974
Query: 1514 QLFMKKNQTLQNEILGHTPRVEDVLQRGQQ-LVEAAEIDCQDLEERLGHLQSSWDRLREA 1572
+ +K ++ + + E + G+ L++ + L+ +L ++++WD +
Sbjct: 2975 ESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQ 3034
Query: 1573 AAGRLQRLRDANE-AQQYYLDADEAEAWIGE-----QELYVISDEIPKDEEGAIVMLKRH 1626
R +L+++ E A +Y + WI + +E+ D P + E +I LK
Sbjct: 3035 VKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLD--PAEGENSIAKLK-- 3090
Query: 1627 LRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKL 1686
Q+ ++ + ++ L + A LLS + E + + + + + +K L
Sbjct: 3091 -SLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCL 3149
Query: 1687 ENMYHLFQLKRET--DDLEQWISEKELVASSPEMGQDF---DHVTLLRDKFRDFARETGA 1741
ENM F+ +E + Q KE + +G ++T+L+ + +
Sbjct: 3150 ENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQALKHQ 3209
Query: 1742 IGQERVDNVNAFIERLIDAGHS----EAATIAEWKDGLNEMWADLLELIDTRMQLLAASY 1797
+ + + +E G S + TIA+ L++ + ++T++Q +
Sbjct: 3210 VDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKCSFLETKLQGIGHFQ 3269
Query: 1798 DLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELH-LLGVQVQQFQ 1856
+ R + ++ DE P VG DA T + AF ++L L+ +
Sbjct: 3270 NTIREMF--SQFAEFDDELDSMAP--VGRDAETLQKQKETIKAFLKKLEALMASNDNANK 3325
Query: 1857 DVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKF-RFFSMARDL 1915
L T I+ + +S LLD R Q+ T + F+S ++
Sbjct: 3326 TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEF 3385
Query: 1916 LSWMESIIRQIETQ----ERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQ 1971
++ E+Q ++ + K Q EIE LG+ L+Q
Sbjct: 3386 SILLQKAEEHEESQGPVGMETETINQQLNMFKVFQ--KEEIEPLQGKQQDVNWLGQGLIQ 3443
Query: 1972 --RQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQE 2029
+ +++ + L V +R K +N+K R +L+ L C
Sbjct: 3444 SAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHC----------------- 3486
Query: 2030 PYLASGDFGHTVDSVEKLIKRHEAFEKSTASW---AERFAALEKPTTLELK-------ER 2079
G D++E L+ SW E A +KP + E K E+
Sbjct: 3487 --------GRFQDALESLL-----------SWMVDTEELVANQKPPSAEFKVVKAQIQEQ 3527
Query: 2080 QIAERPAEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESL 2129
++ +R ++ E + GE + ++ + S L S WE+L
Sbjct: 3528 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEAL 3577
Score = 102 bits (254), Expect = 4e-21
Identities = 315/1749 (18%), Positives = 686/1749 (39%), Gaps = 177/1749 (10%)
Query: 387 KLVSDINRAWESLEEAEYRRELALRNELIR-QEKLEQLARRFDRKAAMRETWLSENQRLV 445
K ++DI+ +E L L L++++ KL +L + + +AM + WL + +
Sbjct: 2577 KDMTDISHGYEDLG-------LLLKDKIAELNTKLSKLQKAQEESSAMMQ-WLQKMNKTA 2628
Query: 446 A---QDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKEN--YHDQKRIT 500
Q D AV+ +++++ E + +V+ L+D EL +EN + R
Sbjct: 2629 TKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWK 2688
Query: 501 ARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFGKH 559
I W L +L R+Q+LE + FQ + + W+ ++ L+ + G
Sbjct: 2689 QMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQTVEAQLKQWL--VEKELMVSVLGPL 2746
Query: 560 LLEVEDL---LQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLE 616
++ L Q+ +++ + A + + + +TAA G P +++++++ +
Sbjct: 2747 SIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQLAAVT 2806
Query: 617 QCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQ 676
Q ++ L+ + R ++Q+ + + +S ++ S LD L+S L +
Sbjct: 2807 QKWDSLTGQLSDRCDWIDQA------IVKSTQYQSLLRSLSDKLSDLD--NKLSSSLAVS 2858
Query: 677 RKHKAFEDELRGLDAHLEQIFQEAH------------GMVARKQFGHPQIEARIKEVSAQ 724
A +L ++I QE + ++++ ++ +++ +
Sbjct: 2859 THPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKS 2918
Query: 725 WDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQ-DAHRLLSGEDVGQDEGATRALG 782
+ ++ A ++LQ A + QFQ + D +AWL + +L
Sbjct: 2919 FKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLI 2978
Query: 783 KKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQ--ALRELYQQVVAQADLR 840
K HKDF + L + E + + + + S +LQ ++ + Q R
Sbjct: 2979 KDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKER 3038
Query: 841 QQRLQEALDLYTVFGE-TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKT 899
+ +L+E+L+ + E + W+ + + L E++ + E + L +EM
Sbjct: 3039 ENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMDQ 3098
Query: 900 LMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNY 959
++ +N ANSL+ V L + + ++ +++ +
Sbjct: 3099 HFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQKFK- 3157
Query: 960 CVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRK----LSGLERDVAAIQARVDALE 1015
+ +E SK + + + D+ D G A K L ++ + A++ +VD +
Sbjct: 3158 --EFQEVSKESKRQLQCAKEQLDI-HDSLGSQAYSNKYLTMLQTQQKSLQALKHQVDLAK 3214
Query: 1016 RESQQLMDSHPEQK--EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDF 1073
R +Q L+ + K D+ + + + + L Q + + S L+ LQ + F
Sbjct: 3215 RLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVD------EKCSFLETKLQGIGHF 3268
Query: 1074 QAWL--SITQKAVASEDMPESLP---EAEQLLQQHAGIK---DEIDGHQDSYQRVKESGE 1125
Q + +Q A +++ P +AE L +Q IK +++ S ++ +
Sbjct: 3269 QNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCK 3328
Query: 1126 KVI-QGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCL-GFQEFQKDAKQAEAI 1183
++ +T P+ + + + LE L N L ++R + + +EF K+ +
Sbjct: 3329 MMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKLKEFSIL 3388
Query: 1184 LSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLYSD 1243
L E H E + I + + + + L + +G + S
Sbjct: 3389 LQKAE---EHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSA 3445
Query: 1244 KIKEKVQLIED-------RHRKNNEK-AQEASVLLRDNLELQNFLQNCQELTLWIND--K 1293
Q +E R + N+K AQ A+ L L F + L W+ D +
Sbjct: 3446 AKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEE 3505
Query: 1294 LLTSQDVSYDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQL-MDEKPQFTALVSQ 1352
L+ +Q E + + + + + L + +E I EG+++ +P + +
Sbjct: 3506 LVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKILK 3565
Query: 1353 KLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTH---ADLNKWISAMEDQLRSDDP-G 1408
+L L W+ L K +T++ S + Q H LN+W++ +E +L + +P G
Sbjct: 3566 QLSLLDSRWEAL--LNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEPIG 3623
Query: 1409 KDLTSVNRMLAKLKRVEDQVNVRKEELGEL--FAQVPSMGEEGGDADLSIEKR------F 1460
+ + +A+ K +ED + + L + Q + D D+ K +
Sbjct: 3624 TQASKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDFSQVWY 3683
Query: 1461 LDLLEPLGRRKKQLESSRAKLQISRDLEDETL-W---VEERLPLAQSADYGTNLQTVQLF 1516
+++ E R + L+ + +I + E E + W V ++L DY T Q
Sbjct: 3684 IEIQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQDYSTEGLWKQ-- 3741
Query: 1517 MKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEID-CQDLEERLGHLQSSWDRLREAAAG 1575
+ + LQ +IL V+ L G +L++ D ++++L +++ + + + +
Sbjct: 3742 QSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITKLSTD 3801
Query: 1576 RLQRLRDANE-AQQYYLDADEAEAWIGEQELYVISDE--IPKDEEGAIVM-----LKRHL 1627
+ L A + A++ + +E W+ + E+ ++S E + K EE + LK+
Sbjct: 3802 VAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKELKKEA 3861
Query: 1628 RQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLE 1687
+ +A+ D ++ +++S L+ EG + ++ + ++ Y + D ++ +++
Sbjct: 3862 KNNKALLD---SLNEVSSALLELVPWRAREG--LEKMVAEDNERYRLVSDTITQKVEEID 3916
Query: 1688 NMYHLFQLKRETDDLE-QWISEKE-LVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQE 1745
Q + D E WI+E E + S ++ + D + + F E
Sbjct: 3917 AAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME------- 3969
Query: 1746 RVDNVNAFIERLIDAGHS-EAATIAEWKDGLNEMWADLLELIDT--------RMQLLAAS 1796
+ I+ L+ +GH A E K + + +L+ DT +QL A
Sbjct: 3970 -ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQ 4028
Query: 1797 YDLHRYFYTGAEILGLIDEKH---RELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQ 1853
+++++ T E+ + E +LP L+ T H + +
Sbjct: 4029 SLVNQFWETYEELWPWLTETQSIISQLPAP-ALEYETLRQQQEEHRQLRELIAEHKPHID 4087
Query: 1854 QFQDVATRLQTAYAGE---------KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTAD 1904
+ +L GE A+ + ++ +E LD + TQ D D
Sbjct: 4088 KMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKID 4147
Query: 1905 KFRFFSMARDLLSWMESIIRQIETQERPRDVSS----VELLMKYHQGINAEIETRSKNFS 1960
+ +ES+ R +E +P +S+ ++ + ++ ++ ++E +
Sbjct: 4148 QI------------LESLERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYE 4195
Query: 1961 ACLELGESLLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASV 2020
+ GE ++ R ++I K Q + ++ WE + L+E R+A +
Sbjct: 4196 TLKQRGEEMIARSGGTDKDISAKAVQ------DKLDQMVFIWENIHTLVE----EREAKL 4245
Query: 2021 AEAWLIAQE 2029
+ +A++
Sbjct: 4246 LDVMELAEK 4254
Score = 94.7 bits (234), Expect = 8e-19
Identities = 157/754 (20%), Positives = 293/754 (38%), Gaps = 78/754 (10%)
Query: 307 YSGLASDLLTWIEQTIT-VLNSRKFANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVL 365
+ G DL W+ T +L S+ ++QL +E F+ K
Sbjct: 4583 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVH-----MEVCAAFEAKEETYKS 4637
Query: 366 LFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLAR 425
L +M A K + + ++++ WES+E R+ L L LA
Sbjct: 4638 LMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEAL-------NLAM 4690
Query: 426 RFDRKAAMRETWLSE-NQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDL 484
F WL++ Q L L V +H+ + ++ E++ L+
Sbjct: 4691 EFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKT 4750
Query: 485 AQELEKENYHDQKRITARKDNIL----RLWSYLQELLQSRRQRLETTLALQKLFQDMLHS 540
L+ Y QK+ N+L W + + L R + L+ K F +
Sbjct: 4751 GTHLK---YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSK 4807
Query: 541 I-DWMDEIKAHLLSA-EFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGK 598
+ +W++E + L S E +++ L +HK + + + V T T + + K
Sbjct: 4808 LMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAK-HSVYDTTNRTGRSLKEK 4866
Query: 599 GYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAE-SWIKEKE 657
D + D +S L ++ + + R+ +LE++ F + +A W+ E
Sbjct: 4867 TSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVE 4926
Query: 658 -QIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEA 716
Q+ D+ V+ L HKAF+ EL + ++ + + A ++ + ++
Sbjct: 4927 PQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKV 4986
Query: 717 RIKEVSAQWDQLKDLAAFCKKNLQDA-ENFFQFQGDADDLKAWLQDAHRLLSGEDV-GQD 774
+++E+S +W+ + L+ + L+ A +F L WL +A + L V D
Sbjct: 4987 QMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDD 5046
Query: 775 EGATRALGKKHKDFLEELEESRGVMEHLEQQAQGFPEEFRDSPD----VTHRLQALRELY 830
E A R L +HK+F+++LEE R + + G PD + H + +R +
Sbjct: 5047 EDALRTLIDQHKEFMKKLEEKRAELN--KATTMGDTVLAICHPDSITTIKHWITIIRARF 5104
Query: 831 QQVVAQADLRQQRLQEALDLYTVFGET-DACELWMGEKEKWLAEME---MPDTLEDLEVV 886
++V+A A QQRL AL E +A W+ E L + + +P +E+++ +
Sbjct: 5105 EEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKAL 5164
Query: 887 QHRFDILDQEMKTLMTQIDGVN-----------------------------LAANSLVES 917
+EM +D V A+SL S
Sbjct: 5165 IAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPS 5224
Query: 918 GHPRSREVKQYQDHLN-TRWQAFQTLVSERREAVDSAL-------RVHNYCVDC--EETS 967
G E K + +L ++WQ L ERR ++ AL N+ D ++
Sbjct: 5225 GSQTQIETKNPRVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYM 5284
Query: 968 KWIT-DKTKVVESTKDLGRDLAGIIAIQRKLSGL 1000
+W+ K++V++ + + +D G I Q + G+
Sbjct: 5285 RWMNHKKSRVMDFFRRIDKDQDGKITRQEFIDGI 5318
Score = 62.8 bits (151), Expect = 4e-09
Identities = 59/292 (20%), Positives = 127/292 (43%), Gaps = 27/292 (9%)
Query: 515 ELLQSRRQRLETTLALQKLFQDMLHS------IDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568
+L+Q R+ L+++L Q L ++ ++ ++W+DE++ L E+G L VE L+
Sbjct: 758 KLMQIRKPLLKSSLLDQNLTEEEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE 817
Query: 569 KHK-----LMEADIAIQGDKVKAIT-AATLKFTEGKGYQPCDPQVIQDRISHLEQCFEEL 622
HK + E + +++ K+ I A LK T +++ LE + +L
Sbjct: 818 NHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYA------------EKLHRLESQYAKL 865
Query: 623 SNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAF 682
N + ++ L+ L F W+ EKE+ + D+ + T++ + H
Sbjct: 866 LNTSRNQERHLDT---LHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAEL 922
Query: 683 EDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742
EL + +++ + + A ++ IEA + QW + L ++++++
Sbjct: 923 MRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKEN 982
Query: 743 ENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELEE 794
+F+F DA + +L++ + + + L ++ +EE EE
Sbjct: 983 TAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEE 1034
Score = 59.7 bits (143), Expect = 3e-08
Identities = 68/313 (21%), Positives = 135/313 (43%), Gaps = 39/313 (12%)
Query: 293 VIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVEK 352
++D + E++ K+ DLL W+++ L+ ++ + L V+ L+ ++ V +
Sbjct: 771 LLDQNLTEEEINMKF---VQDLLNWVDEMQVQLDRTEWGSDLPSVESHLE---NHKNVHR 824
Query: 353 PPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALRN 412
+ E E + IQ M A + Y +L E++Y + L N
Sbjct: 825 AIEEFESSLKEAKISEIQ--MTAPLKLTYAEKLHRL------------ESQYAK---LLN 867
Query: 413 ELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAA--VEAAKKK--HEAIE 468
QE+ F +A WL+E + ++ YD + A+KK H +
Sbjct: 868 TSRNQERHLDTLHNFVSRATNELIWLNEKE----EEEVAYDWSERNTNIARKKDYHAELM 923
Query: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
+ EE +++++++A++L EN+ + I A + + WS++ +L Q Q ++
Sbjct: 924 RELDQKEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENT 983
Query: 529 ALQKLFQDMLHSIDWMDEIKAHL---LSAEFGKHLLEVEDLLQ-----KHKLMEADIAIQ 580
A + F D + D++ +K + S + + ++EDL+Q K +L++ I
Sbjct: 984 AYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIA 1043
Query: 581 GDKVKAITAATLK 593
KA T LK
Sbjct: 1044 NLMGKAKTIIQLK 1056
Score = 51.2 bits (121), Expect = 1e-05
Identities = 48/248 (19%), Positives = 103/248 (41%), Gaps = 11/248 (4%)
Query: 1599 WIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQL-ASRAQGLLSAGHPE 1657
W+ E ++ + E D L+ H RA+E++ ++K+ S Q
Sbjct: 792 WVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTY 851
Query: 1658 GEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDLEQWISEKELVASSPE 1717
E++ RL+ Q YA L + + ++R L+ +++ + R T++L W++EKE + +
Sbjct: 852 AEKLHRLESQ----YAKLLNTSRNQERHLDTLHNF--VSRATNEL-IWLNEKEEEEVAYD 904
Query: 1718 MGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNE 1777
+ ++ +D + RE +E + +V E+L+ H TI ++ +
Sbjct: 905 WSERNTNIARKKDYHAELMRELDQ-KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQT 963
Query: 1778 MWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRV 1837
W+ +L+L Q + + +F E + + D S+ S H++
Sbjct: 964 QWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSS--SIHKL 1021
Query: 1838 HTAFEREL 1845
+ +
Sbjct: 1022 EDLVQESM 1029
Score = 51.2 bits (121), Expect = 1e-05
Identities = 147/816 (18%), Positives = 311/816 (38%), Gaps = 106/816 (12%)
Query: 1249 VQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNL 1308
+Q +E RK E E S L L Q L + E+ K+ Q + + +
Sbjct: 1484 IQQVETTQRKIQENQPENSKTLATQLNQQKMLVSEIEMK---QSKMDECQKYAEQYSATV 1540
Query: 1309 HNKWLKHQAFVAELASHEG-------WLENIDAEGKQLMDEKPQFTALVSQKLE------ 1355
+ L+ + A + S + + D ++ MD + ++TALV+ +
Sbjct: 1541 KDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAG 1600
Query: 1356 -ALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLR-SDDPGKDLTS 1413
+L RL +E ++ +EK +H+ A+ +L KW+S + L+ ++ GK S
Sbjct: 1601 DSLKRLEEEEKSLEEEKKEHVEKAK----------ELQKWVSNISKTLKDAEKAGKPPFS 1650
Query: 1414 VNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQ 1473
K K ++++ +KE+L E + + GD E+ L+ +
Sbjct: 1651 ------KQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYN 1704
Query: 1474 LESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH--- 1530
L S + Q+ + VEE++ + +Y LQ + + + +N ++GH
Sbjct: 1705 LLFSESLKQLQESQTSGDVKVEEKIVAERQQEYKEKLQGICDLLTQT---ENRLIGHQEA 1761
Query: 1531 ------TPRVEDVLQRGQQLVEAAEIDCQDLEERL----GHLQSSWDRL-REAAAGRLQR 1579
T ++ + ++L + + Q L E + L+ + ++L +E A Q+
Sbjct: 1762 FMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDKALIEQK 1821
Query: 1580 LRDAN-EAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGR 1638
L +A + +Q L A++++ + + I +E K A+ L+ + + D+
Sbjct: 1822 LNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEK--VAAVKQLEESKTKIENLLDWLS 1879
Query: 1639 NIKQLASRA---------QGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENM 1689
N+ + + RA Q +G+ I + +V+ + DV + EN+
Sbjct: 1880 NVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLE-TDVDGQVGTTQENL 1938
Query: 1690 YHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDN 1749
+Q + E+ IS+ + V + + Q LL + + + E Q+ +
Sbjct: 1939 NQQYQKVKAQH--EKIISQHQAVIIATQSAQ-----VLLEKQGQYLSPEEKEKLQKNMKE 1991
Query: 1750 VNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809
+ E + + ++ L + AD E L + +L +I
Sbjct: 1992 LKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF---EHWLQQSEQELENLEAGADDI 2048
Query: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGE 1869
GL+ + R+ +SF + + +L + + + + A G+
Sbjct: 2049 NGLMTKLKRQ------------KSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGK 2096
Query: 1870 -----KAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMAR-DLLSWMESII 1923
+Q K + +++L C L D DK++ + A LL+ +++
Sbjct: 2097 VDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACE 2156
Query: 1924 R----------QIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQ 1973
++ + R + + L +E K L+ SLL
Sbjct: 2157 ATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLL--- 2213
Query: 1974 HQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLL 2009
A +I++ L ++ R +++++ R E+L++ L
Sbjct: 2214 -PAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITL 2248
Score = 50.4 bits (119), Expect = 2e-05
Identities = 136/759 (17%), Positives = 292/759 (38%), Gaps = 123/759 (16%)
Query: 964 EETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMD 1023
++ W+ D+ +V + G DL + + + R + ++ + E + ++
Sbjct: 787 QDLLNWV-DEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLK--EAKISEIQM 843
Query: 1024 SHPEQKEDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKA 1083
+ P K ++ LE + L + + QE L L F+ + WL+ ++
Sbjct: 844 TAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHL---DTLHNFVSRATNELIWLNEKEEE 899
Query: 1084 VASEDMPESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRL 1143
+ D E + HA + E+D +++ + V+E E+++ + P L +
Sbjct: 900 EVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLL-ENHPARLTIEAYR 958
Query: 1144 EGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAA 1203
+ T W+ + ++ + + + + EF DAK+A L N + + D
Sbjct: 959 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCD----R 1014
Query: 1204 EAGIRKFEDFLGSMENNRDKVLS-------------------------PVDSGNKLVA-- 1236
+ I K ED + ++++L P+ + + A
Sbjct: 1015 SSSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAIC 1074
Query: 1237 -----EGNLYSDKIKEKVQLIEDRHR-------KNNEKAQEASVLL------RDNLELQN 1278
E +Y D ++ L + HR +A SV ++ ++L N
Sbjct: 1075 DYRQIEITIYKD---DECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN 1131
Query: 1279 FLQNCQE--LTLW----INDKLLTSQDVSYDEARNLHNKWL---------KHQAFVAELA 1323
++ + LTLW IN K + S +E + + +HQ ++ L
Sbjct: 1132 RIEQQYQNVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQ 1191
Query: 1324 SH-EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQ-------HL 1375
S E +LE D++ Q+ + +++ + + EL + + + Q ++
Sbjct: 1192 SRFEDFLE--DSQESQVFSGSD--ITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYI 1247
Query: 1376 SAARSSDLRLQTHADLNKWISAMEDQLRSDDPGKD---LTSVNRMLAKLKRVEDQVNVRK 1432
S R+ LRL+ D + I + L DD + +T ++ +L+R++D +
Sbjct: 1248 SEVRNIRLRLENCED--RLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTIT 1305
Query: 1433 EELGELFAQ------VPSMGEE------GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK 1480
+ E F+Q VP++ E + S+ ++D L+ + K +++ A
Sbjct: 1306 NKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEAL 1365
Query: 1481 LQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQR 1540
+++ ET EE +A N++ + +K+ ++ +E +ED LQ+
Sbjct: 1366 VKLY-----ETKLCEEEAVIADK----NNIENLISTLKQWRSEVDEKRQVFHALEDELQK 1416
Query: 1541 GQQL-------VEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDA 1593
+ + + ++D +E+ L W + RL+ L ++ +YY D
Sbjct: 1417 AKAISDEMFKTYKERDLDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDT 1476
Query: 1594 -DEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQR 1631
+ WI Q++ +I +++ L L QQ+
Sbjct: 1477 YHPLDDWI--QQVETTQRKIQENQPENSKTLATQLNQQK 1513
Score = 35.4 bits (80), Expect = 0.60
Identities = 40/224 (17%), Positives = 93/224 (41%), Gaps = 9/224 (4%)
Query: 1382 DLRLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKLKRV-----EDQVNVRKEELG 1436
++ ++ DL W+ M+ QL + G DL SV L K V E + ++++ ++
Sbjct: 780 EINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 839
Query: 1437 ELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEE 1496
E+ P + + +E ++ LL +++ L++ +SR +E +W+ E
Sbjct: 840 EIQMTAP-LKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHN--FVSR-ATNELIWLNE 895
Query: 1497 RLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLE 1556
+ + D+ + + L E+ ++ V + +QL+ +E
Sbjct: 896 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 955
Query: 1557 ERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADEAEAWI 1600
+Q+ W + + Q +++ +++ DA EA ++
Sbjct: 956 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYL 999
Score = 33.9 bits (76), Expect = 1.8
Identities = 47/212 (22%), Positives = 81/212 (38%), Gaps = 32/212 (15%)
Query: 1808 EILGLIDEKHRELPE-----DVGLDASTAESFHRVHTAFER-ELHLLGVQVQQFQDVATR 1861
++L +DE +L D+ S E+ VH A E E L ++ + Q A
Sbjct: 788 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAP- 846
Query: 1862 LQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMES 1921
L+ YA K + + + LL+ + L DT F S A + L W+
Sbjct: 847 LKLTYA--------EKLHRLESQYAKLLNTSRNQERHL-DTLHNF--VSRATNELIWLNE 895
Query: 1922 IIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIR 1981
+ + +++ YH + E++ + +N + E+ E LL H A I
Sbjct: 896 KEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIE 955
Query: 1982 EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQ 2013
+ R M +W W +L++CQ
Sbjct: 956 -------AYRAAMQTQWS--W-----ILQLCQ 973
Score = 32.0 bits (71), Expect = 6.7
Identities = 47/286 (16%), Positives = 105/286 (36%), Gaps = 20/286 (6%)
Query: 1701 DLEQWISEKELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLIDA 1760
DL W+ E ++ E G D V + ++ R + F L +A
Sbjct: 788 DLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRA-----------IEEFESSLKEA 836
Query: 1761 GHSEAATIAEWK----DGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGA-EILGLIDE 1815
SE A K + L+ + + +L++T LH + E++ L ++
Sbjct: 837 KISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEK 896
Query: 1816 KHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQ 1875
+ E+ D + H REL ++ Q++A +L + I+
Sbjct: 897 EEEEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARL-TIE 955
Query: 1876 NKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQ---ERP 1932
+ W +L C + + F FF+ A++ ++ ++ I+ + +R
Sbjct: 956 AYRAAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRS 1015
Query: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASE 1978
+ +E L++ E+ + + ++++Q + + S+
Sbjct: 1016 SSIHKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSD 1061
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,065,171
Number of Sequences: 37866
Number of extensions: 3397505
Number of successful extensions: 21658
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 133
Number of HSP's successfully gapped in prelim test: 547
Number of HSP's that attempted gapping in prelim test: 13476
Number of HSP's gapped (non-prelim): 4215
length of query: 2137
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2019
effective length of database: 13,779,330
effective search space: 27820467270
effective search space used: 27820467270
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.