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Search of human proteins with 66529203
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|66529203 hypothetical protein LOC57714 [Homo sapiens]
(1063 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|66529203 hypothetical protein LOC57714 [Homo sapiens] 2174 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 55 4e-07
gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens] 55 5e-07
gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens] 55 5e-07
gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens] 55 5e-07
gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens] 55 5e-07
gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens] 55 5e-07
gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens] 55 5e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 54 8e-07
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 51 5e-06
gi|150170670 piccolo isoform 2 [Homo sapiens] 50 1e-05
gi|150378539 piccolo isoform 1 [Homo sapiens] 50 1e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 50 1e-05
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 49 3e-05
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 47 1e-04
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 47 1e-04
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 47 1e-04
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 47 1e-04
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 47 1e-04
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 47 1e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 46 2e-04
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 46 2e-04
gi|4557719 DNA ligase I [Homo sapiens] 46 2e-04
gi|217330641 IWS1 homolog [Homo sapiens] 45 4e-04
gi|27894378 chloride intracellular channel 6 [Homo sapiens] 45 5e-04
gi|125656165 THO complex 2 [Homo sapiens] 44 6e-04
gi|157738619 smoothelin-like 1 [Homo sapiens] 44 6e-04
gi|95147555 microtubule-associated protein 1A [Homo sapiens] 44 8e-04
gi|19923084 polycystin-1L1 [Homo sapiens] 44 8e-04
gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens] 43 0.001
>gi|66529203 hypothetical protein LOC57714 [Homo sapiens]
Length = 1063
Score = 2174 bits (5634), Expect = 0.0
Identities = 1063/1063 (100%), Positives = 1063/1063 (100%)
Query: 1 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 60
MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
Sbjct: 1 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG 60
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL 120
PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL
Sbjct: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL 120
Query: 121 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG 180
TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
Sbjct: 121 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG 180
Query: 181 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE 240
EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE
Sbjct: 181 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE 240
Query: 241 LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP
Sbjct: 241 LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN 360
ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
Sbjct: 301 ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN 360
Query: 361 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL 420
QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL
Sbjct: 361 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL 420
Query: 421 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL 480
HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL
Sbjct: 421 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL 480
Query: 481 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI 540
FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
Sbjct: 481 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI 540
Query: 541 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP 600
LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP
Sbjct: 541 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP 600
Query: 601 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR 660
LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR
Sbjct: 601 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR 660
Query: 661 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA 720
DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
Sbjct: 661 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA 720
Query: 721 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH 780
ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH
Sbjct: 721 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH 780
Query: 781 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL 840
LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL
Sbjct: 781 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL 840
Query: 841 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ 900
SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
Sbjct: 841 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ 900
Query: 901 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD 960
TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD
Sbjct: 901 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD 960
Query: 961 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQVNNLSSWETDSG 1020
MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQVNNLSSWETDSG
Sbjct: 961 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQVNNLSSWETDSG 1020
Query: 1021 SQLCSAMTQLRAMKHPLGLSSSANSEIGKWAPSSLAKGNGAEI 1063
SQLCSAMTQLRAMKHPLGLSSSANSEIGKWAPSSLAKGNGAEI
Sbjct: 1021 SQLCSAMTQLRAMKHPLGLSSSANSEIGKWAPSSLAKGNGAEI 1063
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 55.1 bits (131), Expect = 4e-07
Identities = 79/354 (22%), Positives = 139/354 (39%), Gaps = 33/354 (9%)
Query: 33 DSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKKKK 92
+ E + A+ E E +KEE S + ++PE+ +K+ V+ +K K
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAK------SPAEAKSPEKEEAKSPAEVKSPEKAK 551
Query: 93 RKKKKKGN-----KSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQP 147
K++ KS E A P SP + + A S + P +
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE 611
Query: 148 SQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDA 207
++ P A +P++ + S P EV SP +A++ + A E SP+ ++ E +
Sbjct: 612 AKSPAEAKSPVKEEAKS-PAEV-KSPEKAKSPTKEE-AKSPEKAKSPEKEEAKSPEKAKS 668
Query: 208 SIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPES-----KGGSSEPGTELQTTEQ 262
+ + + + + A +E PE K + P ++
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728
Query: 263 QAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTP-------PFKTHCQEAET 315
+A + A V E A + + A K KT +K P A TP P ++A++
Sbjct: 729 EA-KTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKS 787
Query: 316 KTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKN--EKEQKNQEADVQE 367
K+E+ + E K + ED K PE + VK+ ++E+K QE V+E
Sbjct: 788 PVKEEVKSPE----KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKE 837
Score = 50.1 bits (118), Expect = 1e-05
Identities = 79/345 (22%), Positives = 132/345 (38%), Gaps = 37/345 (10%)
Query: 42 ASASEG-EMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQESKK--KKRKKKKK 98
A EG E E G+E + EGG +E P +A+ +E+K K+ K
Sbjct: 478 AKEEEGKEEEGGEEEEAEGGE---------EETKSPPAEEAASPEKEAKSPVKEEAKSPA 528
Query: 99 GNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPL 158
KS E A P SP +P ++ P + P + ++ P +P
Sbjct: 529 EAKSPEKEEAKSPAEVKSP---EKAKSPAKEEAKSP---PEAKSPEKEEAKSPAEVKSPE 582
Query: 159 EGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQ---DASIPSGGRG 215
+ S E SP +A++ +A EA+S + + + E + + P +
Sbjct: 583 KAK--SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKS 640
Query: 216 LSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAV 275
++E P A + + E + E K + P + +A S A V
Sbjct: 641 PTKEEAKSPEKA-KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA-KSPEKAKSPV 698
Query: 276 AEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTK-----DEMAAAEEKVGK 330
E A + + A +KE+ K P P K +EA+T K E A + EK
Sbjct: 699 KEEAKSPEKAKSPVKEEA---KSPEKAKSPVK---EEAKTPEKAKSPVKEEAKSPEKAKS 752
Query: 331 NEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSP 375
E+ + D+K PE K + ++ ++ ++A VK SP
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAK-SPVKEEVKSP 796
Score = 45.8 bits (107), Expect = 2e-04
Identities = 75/362 (20%), Positives = 130/362 (35%), Gaps = 33/362 (9%)
Query: 23 ERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENP--EEPCSK 80
E A + E S ++ E KEE S ++P EE S
Sbjct: 536 EEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSP 595
Query: 81 ASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQ 140
A E K K++ K A S + SPA +P ++ P +
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE---KA 652
Query: 141 SGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG--EAGVATGSEAQSSPQFQD 198
P + ++ P A +P++ + S E SP++A+A +A EA+S + +
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSP--EKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKS 710
Query: 199 HTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQ 258
+ ++A P + +E P A + ++ PE E +
Sbjct: 711 PVK---EEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK 767
Query: 259 TTEQQAGASAS-----MAVDAVAEPANAVKGAGKEMKE----------KTQRMKQP-PAT 302
T ++ S + A V E + + A +KE K + +K P
Sbjct: 768 TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE 827
Query: 303 TPPFKTHCQEAETKTKDEMAAA-----EEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKE 357
P + +E K ++E A A E+K K E+ ++ KP+ + + AV+ KE
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKE 887
Query: 358 QK 359
K
Sbjct: 888 SK 889
Score = 36.6 bits (83), Expect = 0.13
Identities = 49/250 (19%), Positives = 87/250 (34%), Gaps = 13/250 (5%)
Query: 129 QDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGS 188
++T + Q +++ T + ++ EG E G +A+ E + +
Sbjct: 452 KETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK-----EEEGGEEEEAEGGEEETKSPPA 506
Query: 189 EAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKG 248
E +SP+ ++ ++A P+ + +E P A +E P
Sbjct: 507 EEAASPE-KEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAK 565
Query: 249 GSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKT 308
+ + + + S A + PA A K K + K P P K
Sbjct: 566 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA-KSPEKAKSPVKEEAKSPAEAKSPVK- 623
Query: 309 HCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKP---EGKNRSAAAVKNEKEQKNQEADV 365
+EA++ + + + K E PE K P E K+ A + E K+ E
Sbjct: 624 --EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAK 681
Query: 366 QEVKASTLSP 375
VKA SP
Sbjct: 682 SPVKAEAKSP 691
>gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]
Length = 2852
Score = 54.7 bits (130), Expect = 5e-07
Identities = 84/373 (22%), Positives = 126/373 (33%), Gaps = 29/373 (7%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
Q S TP + P +P+A + + S +GE Q + P P
Sbjct: 1627 QSASSPSTPLTVAGTAAEQVPVSPLAT--RSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1684
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ P P + + +A+ LA+ P + L +
Sbjct: 1685 PSA----PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG 1740
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDS--PLQAQALGEAGV 184
P DT+LP ++ S P P TTPL+ + P + P A+ +A
Sbjct: 1741 LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1800
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA---QEL 241
T +P G A++P+ G EGT S S T A +++
Sbjct: 1801 PT----HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV 1856
Query: 242 LLPESKGGSSEPG-TELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LP S GS+E G TEL A++ VAEP A G + +
Sbjct: 1857 SLPTSMYGSAEGGPTEL------TPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSA 1910
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAE-EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQK 359
T P Q++ ++A A G + EP D E RSA A+ +
Sbjct: 1911 RTAP------QDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLA 1964
Query: 360 NQEADVQEVKAST 372
A E ST
Sbjct: 1965 EALATTTEANTST 1977
>gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]
Length = 2924
Score = 54.7 bits (130), Expect = 5e-07
Identities = 84/373 (22%), Positives = 126/373 (33%), Gaps = 29/373 (7%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
Q S TP + P +P+A + + S +GE Q + P P
Sbjct: 1699 QSASSPSTPLTVAGTAAEQVPVSPLAT--RSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1756
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ P P + + +A+ LA+ P + L +
Sbjct: 1757 PSA----PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG 1812
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDS--PLQAQALGEAGV 184
P DT+LP ++ S P P TTPL+ + P + P A+ +A
Sbjct: 1813 LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1872
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA---QEL 241
T +P G A++P+ G EGT S S T A +++
Sbjct: 1873 PT----HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV 1928
Query: 242 LLPESKGGSSEPG-TELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LP S GS+E G TEL A++ VAEP A G + +
Sbjct: 1929 SLPTSMYGSAEGGPTEL------TPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSA 1982
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAE-EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQK 359
T P Q++ ++A A G + EP D E RSA A+ +
Sbjct: 1983 RTAP------QDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLA 2036
Query: 360 NQEADVQEVKAST 372
A E ST
Sbjct: 2037 EALATTTEANTST 2049
>gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]
Length = 2852
Score = 54.7 bits (130), Expect = 5e-07
Identities = 84/373 (22%), Positives = 126/373 (33%), Gaps = 29/373 (7%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
Q S TP + P +P+A + + S +GE Q + P P
Sbjct: 1627 QSASSPSTPLTVAGTAAEQVPVSPLAT--RSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1684
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ P P + + +A+ LA+ P + L +
Sbjct: 1685 PSA----PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG 1740
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDS--PLQAQALGEAGV 184
P DT+LP ++ S P P TTPL+ + P + P A+ +A
Sbjct: 1741 LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1800
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA---QEL 241
T +P G A++P+ G EGT S S T A +++
Sbjct: 1801 PT----HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV 1856
Query: 242 LLPESKGGSSEPG-TELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LP S GS+E G TEL A++ VAEP A G + +
Sbjct: 1857 SLPTSMYGSAEGGPTEL------TPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSA 1910
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAE-EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQK 359
T P Q++ ++A A G + EP D E RSA A+ +
Sbjct: 1911 RTAP------QDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLA 1964
Query: 360 NQEADVQEVKAST 372
A E ST
Sbjct: 1965 EALATTTEANTST 1977
>gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]
Length = 2924
Score = 54.7 bits (130), Expect = 5e-07
Identities = 84/373 (22%), Positives = 126/373 (33%), Gaps = 29/373 (7%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
Q S TP + P +P+A + + S +GE Q + P P
Sbjct: 1699 QSASSPSTPLTVAGTAAEQVPVSPLAT--RSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1756
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ P P + + +A+ LA+ P + L +
Sbjct: 1757 PSA----PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG 1812
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDS--PLQAQALGEAGV 184
P DT+LP ++ S P P TTPL+ + P + P A+ +A
Sbjct: 1813 LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1872
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA---QEL 241
T +P G A++P+ G EGT S S T A +++
Sbjct: 1873 PT----HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV 1928
Query: 242 LLPESKGGSSEPG-TELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LP S GS+E G TEL A++ VAEP A G + +
Sbjct: 1929 SLPTSMYGSAEGGPTEL------TPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSA 1982
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAE-EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQK 359
T P Q++ ++A A G + EP D E RSA A+ +
Sbjct: 1983 RTAP------QDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLA 2036
Query: 360 NQEADVQEVKAST 372
A E ST
Sbjct: 2037 EALATTTEANTST 2049
>gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens]
Length = 2852
Score = 54.7 bits (130), Expect = 5e-07
Identities = 84/373 (22%), Positives = 126/373 (33%), Gaps = 29/373 (7%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
Q S TP + P +P+A + + S +GE Q + P P
Sbjct: 1627 QSASSPSTPLTVAGTAAEQVPVSPLAT--RSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1684
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ P P + + +A+ LA+ P + L +
Sbjct: 1685 PSA----PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG 1740
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDS--PLQAQALGEAGV 184
P DT+LP ++ S P P TTPL+ + P + P A+ +A
Sbjct: 1741 LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1800
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA---QEL 241
T +P G A++P+ G EGT S S T A +++
Sbjct: 1801 PT----HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV 1856
Query: 242 LLPESKGGSSEPG-TELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LP S GS+E G TEL A++ VAEP A G + +
Sbjct: 1857 SLPTSMYGSAEGGPTEL------TPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSA 1910
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAE-EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQK 359
T P Q++ ++A A G + EP D E RSA A+ +
Sbjct: 1911 RTAP------QDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLA 1964
Query: 360 NQEADVQEVKAST 372
A E ST
Sbjct: 1965 EALATTTEANTST 1977
>gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens]
Length = 2924
Score = 54.7 bits (130), Expect = 5e-07
Identities = 84/373 (22%), Positives = 126/373 (33%), Gaps = 29/373 (7%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
Q S TP + P +P+A + + S +GE Q + P P
Sbjct: 1699 QSASSPSTPLTVAGTAAEQVPVSPLAT--RSLEIVLSTEKGEAGHSQPMGSPASPQPHPL 1756
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ P P + + +A+ LA+ P + L +
Sbjct: 1757 PSA----PPRPAQHTTMATRSPALPPETPAAASLSTATDGLAATPFMSLESTRPSQLLSG 1812
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDS--PLQAQALGEAGV 184
P DT+LP ++ S P P TTPL+ + P + P A+ +A
Sbjct: 1813 LPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPAQTLSPVLPFTPAAMTQAHP 1872
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA---QEL 241
T +P G A++P+ G EGT S S T A +++
Sbjct: 1873 PT----HIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSVVPRKSTTGKVAILSKQV 1928
Query: 242 LLPESKGGSSEPG-TELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
LP S GS+E G TEL A++ VAEP A G + +
Sbjct: 1929 SLPTSMYGSAEGGPTEL------TPATSHPLTPLVAEPEGAQAGTALPVPTSYALSRVSA 1982
Query: 301 ATTPPFKTHCQEAETKTKDEMAAAE-EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQK 359
T P Q++ ++A A G + EP D E RSA A+ +
Sbjct: 1983 RTAP------QDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAPALSIVEGLA 2036
Query: 360 NQEADVQEVKAST 372
A E ST
Sbjct: 2037 EALATTTEANTST 2049
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 53.9 bits (128), Expect = 8e-07
Identities = 50/221 (22%), Positives = 84/221 (38%), Gaps = 12/221 (5%)
Query: 159 EGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQ 218
E +G+ AP GD+ +A GEA SE +P+ + + E +D P +
Sbjct: 1847 ESEGVEAPEAEGDAQ---EAEGEA--QPESEDVEAPEAEGEAQPESEDVETPEAEWEVQP 1901
Query: 219 EGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEP 278
E G E ++ E + E L E + G E Q E+ A+ + +P
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEE-----AAQEAEGQTQP 1956
Query: 279 ANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPED 338
+ V + + +E + A +T QEAE + + E E + E E E+
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVET--QEAEGEAQPESEDVEAPEAEGEMQEAEE 2014
Query: 339 LKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGV 379
+PE A +E + E + Q+ + GV
Sbjct: 2015 EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGV 2055
Score = 46.6 bits (109), Expect = 1e-04
Identities = 81/419 (19%), Positives = 152/419 (36%), Gaps = 50/419 (11%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMEC-GQELKEEG------ 59
Q +++++ PK G+ + A +N+ T A + GE E G+ + E G
Sbjct: 1750 QRLNRDKDPKLGEAEGDAM--AQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQG 1807
Query: 60 -------------GPCLFPGSDSWQENPEEPCSKA-----SWTVQESKKKKRKKKKKGNK 101
G PG E E P ++ S V+ + + ++ +G
Sbjct: 1808 SGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEA 1867
Query: 102 SASSELASLPLSP--ASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLE 159
SE P + A P + P + P S+ ++ + +QP + LE
Sbjct: 1868 QPESEDVEAPEAEGEAQP-ESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALE 1926
Query: 160 GDGLSAPTEVGDSPLQAQALG---EAGVATGSEAQSSPQFQDHTEGEDQDA-SIPSGGRG 215
+G P G +A+ E SE S + ++ + E +D ++
Sbjct: 1927 TEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVET 1986
Query: 216 LSQEGTGPPTS----AGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMA 271
EG P S A E ++A +E PES G ++P +E + ++ G +
Sbjct: 1987 QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ-PESDGVEAQPKSEGEEAQEVEGETQKTE 2045
Query: 272 VDAVAEPANA-VKGAGKEMKEKTQRMKQPPATTPPFK--THCQEAETKTKDEMAAAEEKV 328
DA E A +E +E +++ P QEAE + + E E
Sbjct: 2046 GDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPE 2105
Query: 329 GKNEQGEPEDLK--------KPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGV 379
+ E + E ++ +PE + A + E + +++ + Q+ + G+
Sbjct: 2106 AEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGI 2164
Score = 33.5 bits (75), Expect = 1.1
Identities = 43/162 (26%), Positives = 61/162 (37%), Gaps = 25/162 (15%)
Query: 129 QDTALPHSQAQQSGPTGQPSQPPGTATTPLEG-DGLSAPTEVGDSPLQAQALGEA----- 182
QD+A P S P G + TP +G D S ++G +LGE
Sbjct: 450 QDSASPASSTGL--PEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCI 507
Query: 183 -GVATGSEAQS---SPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAA 238
G G Q +P+ + EG D+S +G S E G P G +R E +
Sbjct: 508 DGAGLGGPEQGGRLTPRARSE-EGASSDSSASTGSHEGSSEWGGRPQGC-PGKARAETSQ 565
Query: 239 QE-----------LLLPESKGGSSEPGTELQTTEQQAGASAS 269
QE L L + + T+ Q TEQ GA+ +
Sbjct: 566 QEASEGGDPASPALSLSSLRSDDLQAETQGQGTEQATGAAVT 607
Score = 32.7 bits (73), Expect = 1.9
Identities = 78/334 (23%), Positives = 115/334 (34%), Gaps = 76/334 (22%)
Query: 9 VSKEETPK--FCSQCGERLPPAAPIADSENNN-STMASASEGE-------------MECG 52
VS P + G R API +++ S +AS GE ++ G
Sbjct: 752 VSPHNAPSAGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASLGEEARDTPQPSSPLVLQVG 811
Query: 53 QELKEEGGP-----CLFPGSDSWQENPEEPCSKASW-------TVQESKKKKRKKKKKGN 100
+ + GP C PG+ QE P +ASW T + +++
Sbjct: 812 RPEQGAVGPHRSHCCSQPGTQPAQEAQRGPSPEASWLCGRYCPTPPRGRPCPQRRSSSCG 871
Query: 101 KSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEG 160
+ SS ++ SP T P P + + S G S+ T G
Sbjct: 872 STGSSHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSG 931
Query: 161 DGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSP-----QFQDHTEGED-------QDAS 208
G E +GV+ S +SSP ++ D+ E D +
Sbjct: 932 GGPQGQEEA------------SGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADET 979
Query: 209 IPSGGRGL-----------SQEGTGPPTSAGEGHSRTEDAAQELLLPESKG---GSSEPG 254
+ G GL S EG G P AG+ S D Q+ PE +G GSS+ G
Sbjct: 980 TGAAGGGLRGPEVDPGDDHSLEGLGEPAQAGQ-QSLEGDPGQD---PEPEGALLGSSDTG 1035
Query: 255 TELQTTEQQAGASASMAVDAVAEPANAVKGAGKE 288
+ G A + V+E A A GA +E
Sbjct: 1036 -----PQSGEGVPQGAAPEGVSE-APAEAGADRE 1063
Score = 32.7 bits (73), Expect = 1.9
Identities = 58/276 (21%), Positives = 101/276 (36%), Gaps = 32/276 (11%)
Query: 1 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEG----EMECGQELK 56
+E P + ++E + GE P + + D++ SEG E E G+ K
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDV-DAQEAEGEAQPESEGVEAPEAE-GEAQK 2112
Query: 57 EEGGPCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSE-LASLPLSPA 115
EG ++ E+ +A Q + + +G SE + +
Sbjct: 2113 AEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEE 2172
Query: 116 SPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
+ L + P + A P S+ ++ +QP E +G+ AP ++ +
Sbjct: 2173 AQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQP--------ELEGVEAP----EAEEE 2220
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTE 235
AQ E +E ++ P+ + T+GE + + S G G S+E + + E
Sbjct: 2221 AQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTP- 2279
Query: 236 DAAQELLLPESKGGSSEPGTELQTTEQQAGASASMA 271
P S GG T Q Q G S+S A
Sbjct: 2280 --------PPSPGGD----TPHQRPGSQTGPSSSRA 2303
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 51.2 bits (121), Expect = 5e-06
Identities = 57/256 (22%), Positives = 103/256 (40%), Gaps = 27/256 (10%)
Query: 137 QAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQF 196
++ ++G +G+P GT EGD + V S + AL +A E P
Sbjct: 10 ESVKAGASGKPEMRLGTQEETSEGDANESSLLVLSSNVPLLALEFLEIAQAKEKAFLPMV 69
Query: 197 QD--HTEGEDQDASIPSGGRGLSQEGTG-PPTSAGEGHSRTEDA---AQELLLPESKGGS 250
H E+ DAS QEG P +SA H + +D+ ++E + P+
Sbjct: 70 SHTFHMRTEESDAS---------QEGDDLPKSSANTSHPKQDDSPKSSEETIQPKEGDIP 120
Query: 251 SEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPF---- 306
P +Q+ ++ S+ A+ + +N K + K ++ K + P A+ P
Sbjct: 121 KAPEETIQSKKEDLPKSSEKAIQP--KESNIPKSSAKPIQPKLGNI--PKASVKPSQPKE 176
Query: 307 ----KTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQE 362
K + ++K +D ++EE + E P+ KP A + K + +E
Sbjct: 177 GDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKE 236
Query: 363 ADVQEVKASTLSPGGG 378
+D+ + T+ P G
Sbjct: 237 SDIPKSPEETIQPKEG 252
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 49.7 bits (117), Expect = 1e-05
Identities = 63/284 (22%), Positives = 104/284 (36%), Gaps = 33/284 (11%)
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASP--- 117
P PG + Q P +P ++ S + ++ K +++ + PL PA P
Sbjct: 315 PAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQ 374
Query: 118 ---CHLTLLSNPWPQDTALP----HSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEV- 169
P P+ A P + AQQ GP P+Q GT + GL +P +
Sbjct: 375 QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434
Query: 170 --GDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQE---GTGPP 224
+P+Q G+ ++S Q T+ Q +P + Q+ PP
Sbjct: 435 GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ---LPGPAKPPPQQPGPAKPPP 491
Query: 225 TSAGEGHSRTEDAAQELLLPESKG----GSSEPGTELQTTEQQAGASASMAVDAVAEPAN 280
G ++ P+ G +PG+ ++Q A S + A+P+
Sbjct: 492 QQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSA 551
Query: 281 -------AVKGAGKEMKEKT--QRMKQPPATTPPFKTHCQEAET 315
+ G+GK ++ T KQPP+ P KT C T
Sbjct: 552 QQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP-KTICPLCNT 594
Score = 41.2 bits (95), Expect = 0.005
Identities = 56/235 (23%), Positives = 80/235 (34%), Gaps = 27/235 (11%)
Query: 14 TPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQEL--KEEGGPCLFPGSDSWQ 71
T Q G PP P ++ + A + G E E+ GP
Sbjct: 339 TKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG 398
Query: 72 ENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWP--- 128
+ P + A Q+ K ++ G +S P P T + P P
Sbjct: 399 KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQS--------PAKAPGPTK-TPVQQPGPGKI 449
Query: 129 --QDTALPHSQAQQSGPTGQPSQPPGTATTPLE--GDGLSAPTEVGDS--PLQAQALGEA 182
Q + AQQ+GPT PSQ PG A P + G P + G + P Q +
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP 509
Query: 183 GVATGSEAQSSPQFQDHTEGEDQ-------DASIPSGGRGLSQEGTGPPTSAGEG 230
A+ SPQ T+ Q A PS + +Q+ T P + G G
Sbjct: 510 PPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 564
Score = 38.5 bits (88), Expect = 0.034
Identities = 53/246 (21%), Positives = 81/246 (32%), Gaps = 26/246 (10%)
Query: 124 SNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAG 183
+ P Q + L AQQ G P QPPGT P + G + P P Q
Sbjct: 329 AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKP------PAQ-------- 374
Query: 184 VATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQE-GTGPPTSAGEGHSRTEDAAQELL 242
TGSE SS Q G A P G+ +Q+ G P + G + L
Sbjct: 375 -QTGSEKPSSEQ-----PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQ 428
Query: 243 LPESKGGSS-----EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMK 297
P G + +PG +Q S +P + + G K ++ K
Sbjct: 429 SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK 488
Query: 298 QPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKE 357
PP K Q+ + K + G + + G + +A + +
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 358 QKNQEA 363
Q++
Sbjct: 549 PSAQQS 554
Score = 37.0 bits (84), Expect = 0.099
Identities = 41/200 (20%), Positives = 75/200 (37%), Gaps = 22/200 (11%)
Query: 161 DGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEG 220
+GL+A G A + + G EA S Q E Q A++ S +GL + G
Sbjct: 14 EGLAAAAAAGGGASGAGSPSHTAIPAGMEADLS---QLSEEERRQIAAVMSRAQGLPK-G 69
Query: 221 TGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPAN 280
+ PP +A + P+ G +PG Q ++ + + + +
Sbjct: 70 SVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRS 129
Query: 281 AVKGAGKEMKEKTQRMKQPPATTPP------------------FKTHCQEAETKTKDEMA 322
+ KE K +T ++ ++ P F ++++ E
Sbjct: 130 PSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEET 189
Query: 323 AAEEKVGKNEQGEPEDLKKP 342
++KV + EQG+PE + KP
Sbjct: 190 TKKQKVVQKEQGKPEGIIKP 209
Score = 34.7 bits (78), Expect = 0.49
Identities = 73/329 (22%), Positives = 117/329 (35%), Gaps = 49/329 (14%)
Query: 72 ENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELAS----LPLSPASPCHLTLLSNPW 127
+ P P + V + K K+ K K SS A+ +P S + P
Sbjct: 736 KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795
Query: 128 PQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATG 187
D+A P +Q PTG+ P + P + G S +++ G+ V
Sbjct: 796 KTDSAKP---SQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPS---SESKGQKQVDPV 849
Query: 188 SEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESK 247
+ + + Q + +P G S GP +AG+ T Q+ P+ +
Sbjct: 850 QKKEEPKKAQTKMSPKPDAKPMPKG----SPTPPGPRPTAGQ----TVPTPQQSPKPQEQ 901
Query: 248 G-------GS------SEPGTELQTTEQQA---GAS----ASMAVDAVAEPA-NAVKGAG 286
GS S+P T +T + GAS AS + +P ++ G G
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961
Query: 287 KEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKN 346
MK+ QPP + P K+ Q K E K E+ EP K
Sbjct: 962 APMKQ-APAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEP--------KA 1012
Query: 347 RSAAAVKNEKEQKNQEADVQEVKASTLSP 375
A VK + +K + +++ K+ T P
Sbjct: 1013 EQAPTVKRTETEK-KPPPIKDSKSLTAEP 1040
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 49.7 bits (117), Expect = 1e-05
Identities = 63/284 (22%), Positives = 104/284 (36%), Gaps = 33/284 (11%)
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASP--- 117
P PG + Q P +P ++ S + ++ K +++ + PL PA P
Sbjct: 315 PAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQ 374
Query: 118 ---CHLTLLSNPWPQDTALP----HSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEV- 169
P P+ A P + AQQ GP P+Q GT + GL +P +
Sbjct: 375 QTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQSPAKAP 434
Query: 170 --GDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQE---GTGPP 224
+P+Q G+ ++S Q T+ Q +P + Q+ PP
Sbjct: 435 GPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQ---LPGPAKPPPQQPGPAKPPP 491
Query: 225 TSAGEGHSRTEDAAQELLLPESKG----GSSEPGTELQTTEQQAGASASMAVDAVAEPAN 280
G ++ P+ G +PG+ ++Q A S + A+P+
Sbjct: 492 QQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSA 551
Query: 281 -------AVKGAGKEMKEKT--QRMKQPPATTPPFKTHCQEAET 315
+ G+GK ++ T KQPP+ P KT C T
Sbjct: 552 QQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLP-KTICPLCNT 594
Score = 41.2 bits (95), Expect = 0.005
Identities = 56/235 (23%), Positives = 80/235 (34%), Gaps = 27/235 (11%)
Query: 14 TPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQEL--KEEGGPCLFPGSDSWQ 71
T Q G PP P ++ + A + G E E+ GP
Sbjct: 339 TKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVG 398
Query: 72 ENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWP--- 128
+ P + A Q+ K ++ G +S P P T + P P
Sbjct: 399 KTPAQQPGPAKPPTQQVGTPKPLAQQPGLQS--------PAKAPGPTK-TPVQQPGPGKI 449
Query: 129 --QDTALPHSQAQQSGPTGQPSQPPGTATTPLE--GDGLSAPTEVGDS--PLQAQALGEA 182
Q + AQQ+GPT PSQ PG A P + G P + G + P Q +
Sbjct: 450 PAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKP 509
Query: 183 GVATGSEAQSSPQFQDHTEGEDQ-------DASIPSGGRGLSQEGTGPPTSAGEG 230
A+ SPQ T+ Q A PS + +Q+ T P + G G
Sbjct: 510 PPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAKPSAQQSTKPVSQTGSG 564
Score = 38.5 bits (88), Expect = 0.034
Identities = 53/246 (21%), Positives = 81/246 (32%), Gaps = 26/246 (10%)
Query: 124 SNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAG 183
+ P Q + L AQQ G P QPPGT P + G + P P Q
Sbjct: 329 AKPPAQPSGLTKPLAQQPGTVKPPVQPPGTTKPPAQPLGPAKP------PAQ-------- 374
Query: 184 VATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQE-GTGPPTSAGEGHSRTEDAAQELL 242
TGSE SS Q G A P G+ +Q+ G P + G + L
Sbjct: 375 -QTGSEKPSSEQ-----PGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPGLQ 428
Query: 243 LPESKGGSS-----EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMK 297
P G + +PG +Q S +P + + G K ++ K
Sbjct: 429 SPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGPAK 488
Query: 298 QPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKE 357
PP K Q+ + K + G + + G + +A + +
Sbjct: 489 PPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQQPGSTKPPSQQPGSAKPSAQQPSPAK 548
Query: 358 QKNQEA 363
Q++
Sbjct: 549 PSAQQS 554
Score = 37.0 bits (84), Expect = 0.099
Identities = 41/200 (20%), Positives = 75/200 (37%), Gaps = 22/200 (11%)
Query: 161 DGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEG 220
+GL+A G A + + G EA S Q E Q A++ S +GL + G
Sbjct: 14 EGLAAAAAAGGGASGAGSPSHTAIPAGMEADLS---QLSEEERRQIAAVMSRAQGLPK-G 69
Query: 221 TGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPAN 280
+ PP +A + P+ G +PG Q ++ + + + +
Sbjct: 70 SVPPAAAESPSMHRKQELDSSHPPKQSGRPPDPGRPAQPGLSKSRTTDTFRSEQKLPGRS 129
Query: 281 AVKGAGKEMKEKTQRMKQPPATTPP------------------FKTHCQEAETKTKDEMA 322
+ KE K +T ++ ++ P F ++++ E
Sbjct: 130 PSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFNPFDLISDSEASQEET 189
Query: 323 AAEEKVGKNEQGEPEDLKKP 342
++KV + EQG+PE + KP
Sbjct: 190 TKKQKVVQKEQGKPEGIIKP 209
Score = 34.7 bits (78), Expect = 0.49
Identities = 73/329 (22%), Positives = 117/329 (35%), Gaps = 49/329 (14%)
Query: 72 ENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELAS----LPLSPASPCHLTLLSNPW 127
+ P P + V + K K+ K K SS A+ +P S + P
Sbjct: 736 KEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPL 795
Query: 128 PQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATG 187
D+A P +Q PTG+ P + P + G S +++ G+ V
Sbjct: 796 KTDSAKP---SQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPS---SESKGQKQVDPV 849
Query: 188 SEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESK 247
+ + + Q + +P G S GP +AG+ T Q+ P+ +
Sbjct: 850 QKKEEPKKAQTKMSPKPDAKPMPKG----SPTPPGPRPTAGQ----TVPTPQQSPKPQEQ 901
Query: 248 G-------GS------SEPGTELQTTEQQA---GAS----ASMAVDAVAEPA-NAVKGAG 286
GS S+P T +T + GAS AS + +P ++ G G
Sbjct: 902 SRRFSLNLGSITDAPKSQPTTPQETVTGKLFGFGASIFSQASNLISTAGQPGPHSQSGPG 961
Query: 287 KEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKN 346
MK+ QPP + P K+ Q K E K E+ EP K
Sbjct: 962 APMKQ-APAPSQPPTSQGPPKSTGQAPPAPAKSIPVKKETKAPAAEKLEP--------KA 1012
Query: 347 RSAAAVKNEKEQKNQEADVQEVKASTLSP 375
A VK + +K + +++ K+ T P
Sbjct: 1013 EQAPTVKRTETEK-KPPPIKDSKSLTAEP 1040
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 49.7 bits (117), Expect = 1e-05
Identities = 72/355 (20%), Positives = 128/355 (36%), Gaps = 26/355 (7%)
Query: 24 RLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASW 83
R A+P+ S A GE G+ K G P + +P
Sbjct: 363 RSASASPLTPCSVTRSVHRCAPAGER--GERRKPNAGGSPAPVRRRPEASP--------- 411
Query: 84 TVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGP 143
VQ+ +KK ++++ + KSA + SL + P + P S+A+ S P
Sbjct: 412 -VQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSP 470
Query: 144 TGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSP--------- 194
+ +P +P G G + P + SP A + V EA+ SP
Sbjct: 471 STSWHRPASPCPSP--GPGHTLPPK-PPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKS 527
Query: 195 QFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPG 254
Q + E + A+ S + T P + + T A L P + P
Sbjct: 528 QSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPS 587
Query: 255 TELQTTEQQAGASASMAVD--AVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQE 312
+ T + A+ +A E + + E+ +RM++ +E
Sbjct: 588 KPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAERE 647
Query: 313 AETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQE 367
AE + ++E A E+ + E+ E +K E + RS + ++ ++ + QE
Sbjct: 648 AEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQE 702
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 48.5 bits (114), Expect = 3e-05
Identities = 67/258 (25%), Positives = 96/258 (37%), Gaps = 16/258 (6%)
Query: 103 ASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDG 162
AS+ AS+PL+PAS P P + AQ T +P Q P T+
Sbjct: 1895 ASAPTASVPLAPASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTS----QS 1950
Query: 163 LSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGE--DQDASIPSGGRGLSQE- 219
P P G VA+G Q +PQ E D + P+ +S++
Sbjct: 1951 SKQPPPSIRLPSAQTPNGTDYVASGKSIQ-TPQSHGTLTAELWDNKVAPPAVLNDISKKL 2009
Query: 220 GTGPPTSAGEGHSRTEDAAQELLLPESKGGSS--EPGTELQTTEQQAGASASMAVDAVAE 277
G P + + P S+G + E G E+ T Q GA AS +
Sbjct: 2010 GPISPPQPPSVSAWNKPLTSFGSAPSSEGAKNGQESGLEIGTDTIQFGAPASNGNENEVV 2069
Query: 278 PANAVKGAGKEMKEKTQRMKQPPATTPPFKTH----CQEAETKTKDEMAAAEEKVGKNEQ 333
P + K A K + K QR KQP A P K E K +E+ KN +
Sbjct: 2070 PVLSEKSADKIPEPKEQRQKQPRA--GPIKAQKLPDLSPVENKEHKPGPIGKERSLKNRK 2127
Query: 334 GEPEDLKKPEGKNRSAAA 351
+ +PEG+ + + A
Sbjct: 2128 VKDAQQVEPEGQEKPSPA 2145
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/388 (19%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 24 RLPPAAPIA-------DSENNNSTMASASEGEMECGQELKEEG----------------G 60
++ PA P A DSE+++ + +S+GE+ +E G
Sbjct: 451 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 510
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELA-SLPLSPASPCH 119
P G + Q E+P + + + S ++ +A ++ A +P + A P
Sbjct: 511 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 570
Query: 120 LTLLSN----PWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
++ P T P + P G G P E S+ +E DS +
Sbjct: 571 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED---SSSSEESDSEEE 627
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSR 233
L V G Q S+ G + TGP + E
Sbjct: 628 KTGLA---VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 684
Query: 234 TEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDA---VAEPANAVKGAGKEMK 290
+E + +E E+ ++ T ++ T+ +A +A+ A A ++ P V A + +
Sbjct: 685 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 744
Query: 291 EKTQRMKQP-------------PATTPPFK---THCQEAETKTKDEMAAAEEKVGKNEQG 334
++K P PA+ P +A+T +++ ++EE+ E+
Sbjct: 745 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804
Query: 335 EPEDLKKPEGKN---RSAAAVKNEKEQK 359
E KP GK R+A A E +K
Sbjct: 805 ETLAQVKPSGKTHQIRAALAPAKESPRK 832
Score = 33.5 bits (75), Expect = 1.1
Identities = 69/370 (18%), Positives = 124/370 (33%), Gaps = 76/370 (20%)
Query: 47 GEMECGQELKEEGGPCLFPGSD--------SWQENPE---EPCSKASWTVQESKKKKRKK 95
G + +E+KE+ G F WQ+ E + ++ +Q K +
Sbjct: 22 GYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDP 81
Query: 96 KKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHS-------QAQQSGPTGQPS 148
S E A + A+P + S+ D LP S + +++G TG
Sbjct: 82 ISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSM 139
Query: 149 QPPGTATT---------------PLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSS 193
P T T P L + TE S A + G+ + +A SS
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 194 PQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSRTEDAAQELLLPESKGGSS 251
+ + ++ D + + + L P G+G + + ++K G
Sbjct: 200 SE-DTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 258
Query: 252 EPGTELQTTE----QQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFK 307
E +E + E ++ +A + A A + GA +++ R PA PP K
Sbjct: 259 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA--PPGK 316
Query: 308 THCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQE 367
T A A+ + GK E+ + + ++E+D +E
Sbjct: 317 TG-----------PAVAKAQAGKREE---------------------DSQSSSEESDSEE 344
Query: 368 VKASTLSPGG 377
+ P G
Sbjct: 345 EAPAQAKPSG 354
Score = 31.2 bits (69), Expect = 5.4
Identities = 81/383 (21%), Positives = 132/383 (34%), Gaps = 84/383 (21%)
Query: 22 GERLPPAAPIADSENNNSTMA-SASEGE----MECGQELKEEGGPCLFPGSDSWQENPEE 76
G+ P AA +++ S+ S S+GE + Q +K P +F + +P
Sbjct: 840 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP---PLIFVDPN---RSPAG 893
Query: 77 PCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLT--LLSNPWPQDTALP 134
P + + S +K + + +S+SSE + PA+ C LT + +N TA P
Sbjct: 894 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC-LTPGIRTNVVTMPTAHP 952
Query: 135 H--------------------SQAQQSGPTGQPS------------------------QP 150
+Q GP Q S QP
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 151 PGTATTPLEGDGLSAPTEVGDSP----LQAQA---LGEAGVATGSEAQSSPQFQDHTEGE 203
P T P G + T SP +QA+ L + + +A +P+ D +E
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDS 1072
Query: 204 DQDASIPSGGRGLSQEGTGPP------TSAGEGHSRTEDAAQELLLPESKGGSSEPGTEL 257
+S G ++G GP T G SRTE +E S+ P L
Sbjct: 1073 SDSSS------GSEEDGEGPQGAKSAHTLVGPTPSRTETLVEETAAESSEDDVVAPSQSL 1126
Query: 258 QTTEQQAGASASMAVDAVAEP-------ANAVKGAGKEMKEKTQRMKQPPATTPPFKTHC 310
+ G + + + + A P ++ A + K + Q A KT
Sbjct: 1127 LSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGG 1186
Query: 311 QEAETKTKDEMAAAEEKVGKNEQ 333
+EA + T + + +K N Q
Sbjct: 1187 KEAASGTTPQKSRKPKKGAGNPQ 1209
Score = 30.8 bits (68), Expect = 7.1
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 35 ENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQ---ESKKK 91
E ++T ++ + G +++G L GS ++ PEE K TV+ +S K
Sbjct: 1304 EKTSTTSKGKAKRDKASGDVKEKKGKGSL--GSQGAKDEPEEELQKGMGTVEGGDQSNPK 1361
Query: 92 KRKKKKKGNK 101
+K+KKK +K
Sbjct: 1362 SKKEKKKSDK 1371
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/388 (19%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 24 RLPPAAPIA-------DSENNNSTMASASEGEMECGQELKEEG----------------G 60
++ PA P A DSE+++ + +S+GE+ +E G
Sbjct: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELA-SLPLSPASPCH 119
P G + Q E+P + + + S ++ +A ++ A +P + A P
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 120 LTLLSN----PWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
++ P T P + P G G P E S+ +E DS +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED---SSSSEESDSEEE 704
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSR 233
L V G Q S+ G + TGP + E
Sbjct: 705 KTGLA---VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761
Query: 234 TEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDA---VAEPANAVKGAGKEMK 290
+E + +E E+ ++ T ++ T+ +A +A+ A A ++ P V A + +
Sbjct: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 291 EKTQRMKQP-------------PATTPPFK---THCQEAETKTKDEMAAAEEKVGKNEQG 334
++K P PA+ P +A+T +++ ++EE+ E+
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Query: 335 EPEDLKKPEGKN---RSAAAVKNEKEQK 359
E KP GK R+A A E +K
Sbjct: 882 ETLAQVKPSGKTHQIRAALAPAKESPRK 909
Score = 38.1 bits (87), Expect = 0.044
Identities = 74/345 (21%), Positives = 128/345 (37%), Gaps = 46/345 (13%)
Query: 22 GERLPPAAPIADSENNNSTMA-SASEGE----MECGQELKEEGGPCLFPGSDSWQENPEE 76
G+ P AA +++ S+ S S+GE + Q +K P +F + +P
Sbjct: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP---PLIFVDPN---RSPAG 970
Query: 77 PCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLT--LLSNPWPQDTALP 134
P + + S +K + + +S+SSE + PA+ C LT + +N TA P
Sbjct: 971 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC-LTPGIRTNVVTMPTAHP 1029
Query: 135 H----------SQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQA---LGE 181
S +++S + G AT G T + +QA+ L +
Sbjct: 1030 RIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRK 1089
Query: 182 AGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPP------TSAGEGHSRTE 235
+ +A +P+ D +E +S G ++G GP T G SRTE
Sbjct: 1090 PKLPEVQQATKAPESSDDSEDSSDSSS------GSEEDGEGPQGAKSAHTLVGPTPSRTE 1143
Query: 236 DAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEP-------ANAVKGAGKE 288
+E S+ P L + G + + + + A P ++ A +
Sbjct: 1144 TLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDD 1203
Query: 289 MKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQ 333
K + Q A KT +EA + T + + +K N Q
Sbjct: 1204 PDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1248
Score = 34.7 bits (78), Expect = 0.49
Identities = 81/412 (19%), Positives = 133/412 (32%), Gaps = 83/412 (20%)
Query: 47 GEMECGQELKEEGGPCLFPGSD--------SWQENPE---EPCSKASWTVQESKKKKRKK 95
G + +E+KE+ G F WQ+ E + ++ +Q K +
Sbjct: 22 GYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDP 81
Query: 96 KKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHS-------QAQQSGPTGQPS 148
S E A + A+P + S+ D LP S + +++G TG
Sbjct: 82 ISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSM 139
Query: 149 QPPGTATT---------------PLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSS 193
P T T P L + TE S A + G+ + +A SS
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 194 PQ----FQDHTEGEDQDASIPSGGRGLS-QEGTGPPTSAGEGHSRTEDA----------- 237
+ D T+ E + + P+ + S P A + D
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 238 AQELLLPESKGGSSEPGTELQ------TTEQQAGASASMAVDAVAEPANAVKGAG----- 286
A+ PE + SSE G+E + T Q + + V A + PA G G
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 287 -----------------KEMKEKTQRMKQPPATTPPFKTHCQ-EAETKTKDEMAA---AE 325
++ + ++ TP K Q +A KT AA A+
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK 379
Query: 326 EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGG 377
E K P P A + + + ++E+D +E + P G
Sbjct: 380 ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Score = 30.8 bits (68), Expect = 7.1
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 35 ENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQ---ESKKK 91
E ++T ++ + G +++G L GS ++ PEE K TV+ +S K
Sbjct: 1343 EKTSTTSKGKAKRDKASGDVKEKKGKGSL--GSQGAKDEPEEELQKGMGTVEGGDQSNPK 1400
Query: 92 KRKKKKKGNK 101
+K+KKK +K
Sbjct: 1401 SKKEKKKSDK 1410
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/388 (19%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 24 RLPPAAPIA-------DSENNNSTMASASEGEMECGQELKEEG----------------G 60
++ PA P A DSE+++ + +S+GE+ +E G
Sbjct: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELA-SLPLSPASPCH 119
P G + Q E+P + + + S ++ +A ++ A +P + A P
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 120 LTLLSN----PWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
++ P T P + P G G P E S+ +E DS +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED---SSSSEESDSEEE 704
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSR 233
L V G Q S+ G + TGP + E
Sbjct: 705 KTGLA---VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761
Query: 234 TEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDA---VAEPANAVKGAGKEMK 290
+E + +E E+ ++ T ++ T+ +A +A+ A A ++ P V A + +
Sbjct: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 291 EKTQRMKQP-------------PATTPPFK---THCQEAETKTKDEMAAAEEKVGKNEQG 334
++K P PA+ P +A+T +++ ++EE+ E+
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Query: 335 EPEDLKKPEGKN---RSAAAVKNEKEQK 359
E KP GK R+A A E +K
Sbjct: 882 ETLAQVKPSGKTHQIRAALAPAKESPRK 909
Score = 34.7 bits (78), Expect = 0.49
Identities = 81/412 (19%), Positives = 133/412 (32%), Gaps = 83/412 (20%)
Query: 47 GEMECGQELKEEGGPCLFPGSD--------SWQENPE---EPCSKASWTVQESKKKKRKK 95
G + +E+KE+ G F WQ+ E + ++ +Q K +
Sbjct: 22 GYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDP 81
Query: 96 KKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHS-------QAQQSGPTGQPS 148
S E A + A+P + S+ D LP S + +++G TG
Sbjct: 82 ISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSM 139
Query: 149 QPPGTATT---------------PLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSS 193
P T T P L + TE S A + G+ + +A SS
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 194 PQ----FQDHTEGEDQDASIPSGGRGLS-QEGTGPPTSAGEGHSRTEDA----------- 237
+ D T+ E + + P+ + S P A + D
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 238 AQELLLPESKGGSSEPGTELQ------TTEQQAGASASMAVDAVAEPANAVKGAG----- 286
A+ PE + SSE G+E + T Q + + V A + PA G G
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 287 -----------------KEMKEKTQRMKQPPATTPPFKTHCQ-EAETKTKDEMAA---AE 325
++ + ++ TP K Q +A KT AA A+
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK 379
Query: 326 EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGG 377
E K P P A + + + ++E+D +E + P G
Sbjct: 380 ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Score = 31.6 bits (70), Expect = 4.2
Identities = 80/377 (21%), Positives = 132/377 (35%), Gaps = 73/377 (19%)
Query: 22 GERLPPAAPIADSENNNSTMA-SASEGE----MECGQELKEEGGPCLFPGSDSWQENPEE 76
G+ P AA +++ S+ S S+GE + Q +K P +F + +P
Sbjct: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP---PLIFVDPN---RSPAG 970
Query: 77 PCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLT--LLSNPWPQDTALP 134
P + + S +K + + +S+SSE + PA+ C LT + +N TA P
Sbjct: 971 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC-LTPGIRTNVVTMPTAHP 1029
Query: 135 H--------------------SQAQQSGPTGQPS------------------------QP 150
+Q GP Q S QP
Sbjct: 1030 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1089
Query: 151 PGTATTPLEGDGLSAPTEVGDSP----LQAQA---LGEAGVATGSEAQSSPQFQDHTEGE 203
P T P G + T SP +QA+ L + + +A +P+ D +E +
Sbjct: 1090 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSE-D 1148
Query: 204 DQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQ 263
D+S S G +G + G SRTE +E S+ P L +
Sbjct: 1149 SSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMT 1208
Query: 264 AGASASMAVDAVAEP-------ANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETK 316
G + + + + A P ++ A + K + Q A KT +EA +
Sbjct: 1209 PGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1268
Query: 317 TKDEMAAAEEKVGKNEQ 333
T + + +K N Q
Sbjct: 1269 TTPQKSRKPKKGAGNPQ 1285
Score = 30.8 bits (68), Expect = 7.1
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 35 ENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQ---ESKKK 91
E ++T ++ + G +++G L GS ++ PEE K TV+ +S K
Sbjct: 1380 EKTSTTSKGKAKRDKASGDVKEKKGKGSL--GSQGAKDEPEEELQKGMGTVEGGDQSNPK 1437
Query: 92 KRKKKKKGNK 101
+K+KKK +K
Sbjct: 1438 SKKEKKKSDK 1447
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/388 (19%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 24 RLPPAAPIA-------DSENNNSTMASASEGEMECGQELKEEG----------------G 60
++ PA P A DSE+++ + +S+GE+ +E G
Sbjct: 451 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 510
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELA-SLPLSPASPCH 119
P G + Q E+P + + + S ++ +A ++ A +P + A P
Sbjct: 511 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 570
Query: 120 LTLLSN----PWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
++ P T P + P G G P E S+ +E DS +
Sbjct: 571 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED---SSSSEESDSEEE 627
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSR 233
L V G Q S+ G + TGP + E
Sbjct: 628 KTGLA---VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 684
Query: 234 TEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDA---VAEPANAVKGAGKEMK 290
+E + +E E+ ++ T ++ T+ +A +A+ A A ++ P V A + +
Sbjct: 685 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 744
Query: 291 EKTQRMKQP-------------PATTPPFK---THCQEAETKTKDEMAAAEEKVGKNEQG 334
++K P PA+ P +A+T +++ ++EE+ E+
Sbjct: 745 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804
Query: 335 EPEDLKKPEGKN---RSAAAVKNEKEQK 359
E KP GK R+A A E +K
Sbjct: 805 ETLAQVKPSGKTHQIRAALAPAKESPRK 832
Score = 33.5 bits (75), Expect = 1.1
Identities = 69/370 (18%), Positives = 124/370 (33%), Gaps = 76/370 (20%)
Query: 47 GEMECGQELKEEGGPCLFPGSD--------SWQENPE---EPCSKASWTVQESKKKKRKK 95
G + +E+KE+ G F WQ+ E + ++ +Q K +
Sbjct: 22 GYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDP 81
Query: 96 KKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHS-------QAQQSGPTGQPS 148
S E A + A+P + S+ D LP S + +++G TG
Sbjct: 82 ISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSM 139
Query: 149 QPPGTATT---------------PLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSS 193
P T T P L + TE S A + G+ + +A SS
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 194 PQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSRTEDAAQELLLPESKGGSS 251
+ + ++ D + + + L P G+G + + ++K G
Sbjct: 200 SE-DTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKP 258
Query: 252 EPGTELQTTE----QQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFK 307
E +E + E ++ +A + A A + GA +++ R PA PP K
Sbjct: 259 EEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPA--PPGK 316
Query: 308 THCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQE 367
T A A+ + GK E+ + + ++E+D +E
Sbjct: 317 TG-----------PAVAKAQAGKREE---------------------DSQSSSEESDSEE 344
Query: 368 VKASTLSPGG 377
+ P G
Sbjct: 345 EAPAQAKPSG 354
Score = 31.6 bits (70), Expect = 4.2
Identities = 80/377 (21%), Positives = 132/377 (35%), Gaps = 73/377 (19%)
Query: 22 GERLPPAAPIADSENNNSTMA-SASEGE----MECGQELKEEGGPCLFPGSDSWQENPEE 76
G+ P AA +++ S+ S S+GE + Q +K P +F + +P
Sbjct: 840 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP---PLIFVDPN---RSPAG 893
Query: 77 PCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLT--LLSNPWPQDTALP 134
P + + S +K + + +S+SSE + PA+ C LT + +N TA P
Sbjct: 894 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC-LTPGIRTNVVTMPTAHP 952
Query: 135 H--------------------SQAQQSGPTGQPS------------------------QP 150
+Q GP Q S QP
Sbjct: 953 RIAPKASMAGASSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQP 1012
Query: 151 PGTATTPLEGDGLSAPTEVGDSP----LQAQA---LGEAGVATGSEAQSSPQFQDHTEGE 203
P T P G + T SP +QA+ L + + +A +P+ D +E +
Sbjct: 1013 PVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSE-D 1071
Query: 204 DQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQ 263
D+S S G +G + G SRTE +E S+ P L +
Sbjct: 1072 SSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMT 1131
Query: 264 AGASASMAVDAVAEP-------ANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETK 316
G + + + + A P ++ A + K + Q A KT +EA +
Sbjct: 1132 PGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1191
Query: 317 TKDEMAAAEEKVGKNEQ 333
T + + +K N Q
Sbjct: 1192 TTPQKSRKPKKGAGNPQ 1208
Score = 30.8 bits (68), Expect = 7.1
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 35 ENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQ---ESKKK 91
E ++T ++ + G +++G L GS ++ PEE K TV+ +S K
Sbjct: 1303 EKTSTTSKGKAKRDKASGDVKEKKGKGSL--GSQGAKDEPEEELQKGMGTVEGGDQSNPK 1360
Query: 92 KRKKKKKGNK 101
+K+KKK +K
Sbjct: 1361 SKKEKKKSDK 1370
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/388 (19%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 24 RLPPAAPIA-------DSENNNSTMASASEGEMECGQELKEEG----------------G 60
++ PA P A DSE+++ + +S+GE+ +E G
Sbjct: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELA-SLPLSPASPCH 119
P G + Q E+P + + + S ++ +A ++ A +P + A P
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 120 LTLLSN----PWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
++ P T P + P G G P E S+ +E DS +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED---SSSSEESDSEEE 704
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSR 233
L V G Q S+ G + TGP + E
Sbjct: 705 KTGLA---VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761
Query: 234 TEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDA---VAEPANAVKGAGKEMK 290
+E + +E E+ ++ T ++ T+ +A +A+ A A ++ P V A + +
Sbjct: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 291 EKTQRMKQP-------------PATTPPFK---THCQEAETKTKDEMAAAEEKVGKNEQG 334
++K P PA+ P +A+T +++ ++EE+ E+
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Query: 335 EPEDLKKPEGKN---RSAAAVKNEKEQK 359
E KP GK R+A A E +K
Sbjct: 882 ETLAQVKPSGKTHQIRAALAPAKESPRK 909
Score = 38.5 bits (88), Expect = 0.034
Identities = 73/339 (21%), Positives = 128/339 (37%), Gaps = 35/339 (10%)
Query: 22 GERLPPAAPIADSENNNSTMA-SASEGE----MECGQELKEEGGPCLFPGSDSWQENPEE 76
G+ P AA +++ S+ S S+GE + Q +K P +F + +P
Sbjct: 917 GKTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKP---PLIFVDPN---RSPAG 970
Query: 77 PCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLT--LLSNPWPQDTALP 134
P + + S +K + + +S+SSE + PA+ C LT + +N TA P
Sbjct: 971 PAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQC-LTPGIRTNVVTMPTAHP 1029
Query: 135 H----------SQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQA---LGE 181
S +++S + G AT G T + +QA+ L +
Sbjct: 1030 RIAPKASMAGASSSKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRK 1089
Query: 182 AGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQEL 241
+ +A +P+ D +E + D+S S G +G + G SRTE +E
Sbjct: 1090 PKLPEVQQATKAPESSDDSE-DSSDSSSGSEEDGEGPQGAKSAHTLGPTPSRTETLVEET 1148
Query: 242 LLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEP-------ANAVKGAGKEMKEKTQ 294
S+ P L + G + + + + A P ++ A + K +
Sbjct: 1149 AAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQE 1208
Query: 295 RMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQ 333
Q A KT +EA + T + + +K N Q
Sbjct: 1209 AKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKGAGNPQ 1247
Score = 34.7 bits (78), Expect = 0.49
Identities = 81/412 (19%), Positives = 133/412 (32%), Gaps = 83/412 (20%)
Query: 47 GEMECGQELKEEGGPCLFPGSD--------SWQENPE---EPCSKASWTVQESKKKKRKK 95
G + +E+KE+ G F WQ+ E + ++ +Q K +
Sbjct: 22 GYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDP 81
Query: 96 KKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHS-------QAQQSGPTGQPS 148
S E A + A+P + S+ D LP S + +++G TG
Sbjct: 82 ISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSM 139
Query: 149 QPPGTATT---------------PLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSS 193
P T T P L + TE S A + G+ + +A SS
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 194 PQ----FQDHTEGEDQDASIPSGGRGLS-QEGTGPPTSAGEGHSRTEDA----------- 237
+ D T+ E + + P+ + S P A + D
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 238 AQELLLPESKGGSSEPGTELQ------TTEQQAGASASMAVDAVAEPANAVKGAG----- 286
A+ PE + SSE G+E + T Q + + V A + PA G G
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 287 -----------------KEMKEKTQRMKQPPATTPPFKTHCQ-EAETKTKDEMAA---AE 325
++ + ++ TP K Q +A KT AA A+
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK 379
Query: 326 EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGG 377
E K P P A + + + ++E+D +E + P G
Sbjct: 380 ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Score = 30.8 bits (68), Expect = 7.1
Identities = 20/70 (28%), Positives = 35/70 (50%), Gaps = 5/70 (7%)
Query: 35 ENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPCSKASWTVQ---ESKKK 91
E ++T ++ + G +++G L GS ++ PEE K TV+ +S K
Sbjct: 1342 EKTSTTSKGKAKRDKASGDVKEKKGKGSL--GSQGAKDEPEEELQKGMGTVEGGDQSNPK 1399
Query: 92 KRKKKKKGNK 101
+K+KKK +K
Sbjct: 1400 SKKEKKKSDK 1409
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/388 (19%), Positives = 138/388 (35%), Gaps = 58/388 (14%)
Query: 24 RLPPAAPIA-------DSENNNSTMASASEGEMECGQELKEEG----------------G 60
++ PA P A DSE+++ + +S+GE+ +E G
Sbjct: 528 KVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG 587
Query: 61 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELA-SLPLSPASPCH 119
P G + Q E+P + + + S ++ +A ++ A +P + A P
Sbjct: 588 PPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKK 647
Query: 120 LTLLSN----PWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQ 175
++ P T P + P G G P E S+ +E DS +
Sbjct: 648 TNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAED---SSSSEESDSEEE 704
Query: 176 AQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSA--GEGHSR 233
L V G Q S+ G + TGP + E
Sbjct: 705 KTGLA---VTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQED 761
Query: 234 TEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDA---VAEPANAVKGAGKEMK 290
+E + +E E+ ++ T ++ T+ +A +A+ A A ++ P V A + +
Sbjct: 762 SESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQ 821
Query: 291 EKTQRMKQP-------------PATTPPFK---THCQEAETKTKDEMAAAEEKVGKNEQG 334
++K P PA+ P +A+T +++ ++EE+ E+
Sbjct: 822 RSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Query: 335 EPEDLKKPEGKN---RSAAAVKNEKEQK 359
E KP GK R+A A E +K
Sbjct: 882 ETLAQVKPSGKTHQIRAALAPAKESPRK 909
Score = 34.7 bits (78), Expect = 0.49
Identities = 81/412 (19%), Positives = 133/412 (32%), Gaps = 83/412 (20%)
Query: 47 GEMECGQELKEEGGPCLFPGSD--------SWQENPE---EPCSKASWTVQESKKKKRKK 95
G + +E+KE+ G F WQ+ E + ++ +Q K +
Sbjct: 22 GYVRAAREVKEQSGQKCFLAQPVTLLDIYTHWQQTSELGRKRKAEEDAALQAKKTRVSDP 81
Query: 96 KKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHS-------QAQQSGPTGQPS 148
S E A + A+P + S+ D LP S + +++G TG
Sbjct: 82 ISTSESSEEEEEAEAETAKATPRLASTNSSVLGAD--LPSSMKEKAKAETEKAGKTGNSM 139
Query: 149 QPPGTATT---------------PLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSS 193
P T T P L + TE S A + G+ + +A SS
Sbjct: 140 PHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSS 199
Query: 194 PQ----FQDHTEGEDQDASIPSGGRGLS-QEGTGPPTSAGEGHSRTEDA----------- 237
+ D T+ E + + P+ + S P A + D
Sbjct: 200 SEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGALPP 259
Query: 238 AQELLLPESKGGSSEPGTELQ------TTEQQAGASASMAVDAVAEPANAVKGAG----- 286
A+ PE + SSE G+E + T Q + + V A + PA G G
Sbjct: 260 AKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAP 319
Query: 287 -----------------KEMKEKTQRMKQPPATTPPFKTHCQ-EAETKTKDEMAA---AE 325
++ + ++ TP K Q +A KT AA A+
Sbjct: 320 PGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAK 379
Query: 326 EKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGG 377
E K P P A + + + ++E+D +E + P G
Sbjct: 380 ESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 46.2 bits (108), Expect = 2e-04
Identities = 61/263 (23%), Positives = 94/263 (35%), Gaps = 38/263 (14%)
Query: 10 SKEETPKFCSQCGERLPPAAPIADSENNNS----------TMASASEGEMECGQELKEEG 59
S+ TP S+ R A + S+ + S T A A E
Sbjct: 248 SRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGD 307
Query: 60 GPCLFPGSDSWQE-NPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPC 118
P PG+ S Q + E +K + E K K +K+K S S E +S P +P
Sbjct: 308 APFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPT 367
Query: 119 HLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQA 178
L A++ G + QP ATTPL + ++ P+E + ++
Sbjct: 368 PLL----------------AERHGGSPQP-----LATTPLSQEPVNPPSEASPTRDRSPP 406
Query: 179 LGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGR-----GLSQEGTGPPTSAGEGHSR 233
+ S ++SSP T+ +S P + G +E + PTS H R
Sbjct: 407 KSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGR 466
Query: 234 TEDAAQELLLPESK-GGSSEPGT 255
+ P + G S P T
Sbjct: 467 AKRDKSHSHTPSRRMGRSRSPAT 489
Score = 42.0 bits (97), Expect = 0.003
Identities = 68/321 (21%), Positives = 111/321 (34%), Gaps = 49/321 (15%)
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRK---------KKKKGNKSASSELASLP------ 111
S+S + P K+ ++SK KKRK K ++ ++S S++ AS
Sbjct: 222 SESKKRKHRSPTPKSK---RKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSR 278
Query: 112 -LSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVG 170
S A+ H T L+ P + + G P PGT +T S+P
Sbjct: 279 SRSAAAKTHTTALAGRSPSPAS------GRRGEGDAPFSEPGTTSTQRP----SSPETAT 328
Query: 171 DSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIP-----SGGRG-------LSQ 218
P + S + SP + + G + A P GG LSQ
Sbjct: 329 KQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQ 388
Query: 219 EGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEP 278
E PP+ A R+ + E L S SS P + + A +S A A
Sbjct: 389 EPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPA-- 446
Query: 279 ANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPED 338
G+ +E+ + K+H + + A K G++ P
Sbjct: 447 ----PGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTP-- 500
Query: 339 LKKPEGKNRSAAAVKNEKEQK 359
K+ ++RS ++ Q+
Sbjct: 501 TKRGHSRSRSPQWRRSRSAQR 521
Score = 38.9 bits (89), Expect = 0.026
Identities = 61/299 (20%), Positives = 106/299 (35%), Gaps = 25/299 (8%)
Query: 7 QHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPG 66
+ VS +P + R PP+AP + T A GQ + L P
Sbjct: 2391 ERVSGRTSPPLLDRARSRTPPSAP----SQSRMTSERAPSPSSRMGQAPSQS----LLPP 2442
Query: 67 SDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNP 126
+ Q+ P P A ++ Q + G++S SS + S A H +LS P
Sbjct: 2443 A---QDQPRSPVPSA-FSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGD-HNGMLSVP 2497
Query: 127 WPQDTALPHSQAQQSGPTGQPSQPPGTAT--TPLEGDGLSAPTEVGDSPLQAQALGEAGV 184
P +PHS + + QP A E S+ + S + + +
Sbjct: 2498 AP---GVPHSDVGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSS 2554
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPS---GGRGLSQEGTGPPTSAGEGHSRTEDAAQEL 241
++GS + S + E +PS + +EG P + + R+ ++
Sbjct: 2555 SSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSS 2614
Query: 242 LLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP 300
S SS + ++ + +S+S + + PA G + K K+PP
Sbjct: 2615 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAK----PGPQALPKPASPKKPP 2669
Score = 32.0 bits (71), Expect = 3.2
Identities = 64/313 (20%), Positives = 102/313 (32%), Gaps = 45/313 (14%)
Query: 79 SKASWTVQESKKKKRKKKKKGNKS-ASSELASLPLSPASPCHLTLLS-------NPWPQD 130
S +S + +KKK+KKK +G +S +SS S H + +P P+
Sbjct: 177 SSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKHRSPTPKS 236
Query: 131 TALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEA 190
+ ++ + P+ A D S+ D+ A T + A
Sbjct: 237 KRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASS----SDTSRSRSRSAAAKTHTTALA 292
Query: 191 QSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTED---------AAQEL 241
SP GE DA G +Q + P T+ + S ED A +
Sbjct: 293 GRSPSPASGRRGEG-DAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPS 351
Query: 242 LLPE-SKGGSSEPGTELQTTEQQAGASASMAVDAVA-EPANAVKGAG-----------KE 288
PE S G P E+ G+ +A ++ EP N A ++
Sbjct: 352 PSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEK 411
Query: 289 MKEKTQRMKQPPATTP-PFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNR 347
+ + + PP+ P H + K A + E P KNR
Sbjct: 412 LPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHR---------EISSSPTSKNR 462
Query: 348 SAAAVKNEKEQKN 360
S K +K +
Sbjct: 463 SHGRAKRDKSHSH 475
Score = 31.6 bits (70), Expect = 4.2
Identities = 32/156 (20%), Positives = 58/156 (37%), Gaps = 15/156 (9%)
Query: 79 SKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQA 138
S +S + S G+ S+ SE +SLP+ P + L P P T P
Sbjct: 2537 SSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQP----EVALKRVPSP--TPAPKEAV 2590
Query: 139 QQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQD 198
++ G+P +P TP + S+ + S + + + ++ S + SS
Sbjct: 2591 RE----GRPPEP-----TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2641
Query: 199 HTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRT 234
+ + G + L + + GE SR+
Sbjct: 2642 SSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRS 2677
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 46.2 bits (108), Expect = 2e-04
Identities = 68/238 (28%), Positives = 100/238 (42%), Gaps = 34/238 (14%)
Query: 159 EGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQ 218
+G A EVG+ QA+ G + EA+ SP+ T+ E AS G G SQ
Sbjct: 647 QGGEEQACWEVGEDK-QAEPGGRLDIR--EEAEGSPE----TKVEAGKASEDRGEAGGSQ 699
Query: 219 E-------GTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMA 271
E G+ T A E S+ + A + E+KG EPG + T E++
Sbjct: 700 ETKVRLREGSREETEAKEEKSKGQKKADSM---EAKG-VEEPGGDEYTDEKEK--EIERE 753
Query: 272 VDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEK---V 328
D E A AG+++++ Q + A QEAE +DE EK
Sbjct: 754 EDEQREEAQVE--AGRDLEQGAQ--EDQVAEEKWEVVQKQEAEGVREDEDKGQREKGYHE 809
Query: 329 GKNEQGEPEDLKKPEGKNRSAAA-VKNEKEQKNQEADVQE------VKASTLSPGGGV 379
+ +QG+ ED + PE A V E+E + EA+ + ++ TLS G GV
Sbjct: 810 ARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYLEEDTLSEGSGV 867
>gi|4557719 DNA ligase I [Homo sapiens]
Length = 919
Score = 45.8 bits (107), Expect = 2e-04
Identities = 65/282 (23%), Positives = 106/282 (37%), Gaps = 25/282 (8%)
Query: 65 PGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLS 124
P + + PE+ S +S +E++ + K+ N SE S P L S
Sbjct: 11 PKKEGKAKKPEKEASNSS---RETEPPPKAALKEWN-GVVSESDSPVKRPGRKAARVLGS 66
Query: 125 NPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGV 184
+D AL ++ Q+ PP AT+P LS SP+ + G
Sbjct: 67 EGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLS-----DTSPMDSSPSGIPKR 121
Query: 185 ATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLP 244
T + Q+ E + +D + + +E P S E TE ++ P
Sbjct: 122 RTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQP 181
Query: 245 ESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTP 304
+ P L+T++ A ++V+EP A K +E +E+T+ ++ P T
Sbjct: 182 TT------PPKPLKTSK------AETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLS 229
Query: 305 PFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKN 346
F T + A K E EE ++G E P G N
Sbjct: 230 SFFTPRKPAVKKEVKE----EEPGAPGKEGAAEGPLDPSGYN 267
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 45.1 bits (105), Expect = 4e-04
Identities = 85/384 (22%), Positives = 139/384 (36%), Gaps = 57/384 (14%)
Query: 19 SQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEEPC 78
S+ ER P P +DSEN + S+ E E ++L PGSDS EN E
Sbjct: 95 SESEERAEP--PASDSENEDVNQ-HGSDSESEETRKL---------PGSDS--ENEELLN 140
Query: 79 SKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQA 138
AS + E K + ++ SE+ L SPAS P D+
Sbjct: 141 GHASDSENEDVGK--------HPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPR 192
Query: 139 QQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQD 198
Q+ + + +PP + E + L P +V DS + +A + E P+ D
Sbjct: 193 HQASDS-ENEEPPKPRMSDSESEELPKP-QVSDSESEEPPRHQASDSENEELPK-PRISD 249
Query: 199 --------HTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGS 250
H + ++ +P R E PP + E + ES+G
Sbjct: 250 SESEDPPRHQASDSENEELPKP-RISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
Query: 251 SEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKT------QRMKQPPATTP 304
P ++ +T + + D + KG EM+ + K+ ++
Sbjct: 309 KGPASDSETEDASRHKQKPESDD---DSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDS 365
Query: 305 PFKTHCQEAETKTKDEMAAAEEKVGKNEQ---GEPEDLKKPEGK-----------NRSAA 350
+ H ++ +DE EEKV K + + ED +K K + A
Sbjct: 366 EEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAV 425
Query: 351 AVKNEKEQKNQEADVQEVKASTLS 374
+ K+ K +K +D +E LS
Sbjct: 426 SDKSGKREKTIASDSEEEAGKELS 449
Score = 30.8 bits (68), Expect = 7.1
Identities = 38/182 (20%), Positives = 78/182 (42%), Gaps = 18/182 (9%)
Query: 188 SEAQSSPQFQDH--TEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPE 245
SE S Q D T +D+ S G ++++ +G T + E HS E + +E LP+
Sbjct: 3 SEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVERHSENETSDREDGLPK 62
Query: 246 SKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPAT--- 302
G + +E + + A D+ +E + K + E +E+ +PPA+
Sbjct: 63 --------GHHVTDSENDEPLNLN-ASDSESEELHRQKDSDSESEERA----EPPASDSE 109
Query: 303 TPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQE 362
H ++E++ ++ ++ + + G D + + A+ + E+ QK+
Sbjct: 110 NEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPA 169
Query: 363 AD 364
+D
Sbjct: 170 SD 171
>gi|27894378 chloride intracellular channel 6 [Homo sapiens]
Length = 686
Score = 44.7 bits (104), Expect = 5e-04
Identities = 57/234 (24%), Positives = 87/234 (37%), Gaps = 33/234 (14%)
Query: 139 QQSGPTGQPSQPPGTATTPLE-----GDGLSAPTEVGDSPLQAQALG---EAGVATGSEA 190
Q GP G G ++ GD + A VGDS G EAGV G
Sbjct: 211 QAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSV 270
Query: 191 QSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGS 250
++ EG D+ G G ++ +G P +G+G + A E+ ES G S
Sbjct: 271 EA--------EGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRS 322
Query: 251 SEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHC 310
PG EL + + A P +A AG++ R+ P P
Sbjct: 323 --PG-ELAWDAAEEAEVPGVKGSEEAAPGDARADAGED------RVGDGPQQEPG----- 368
Query: 311 QEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEAD 364
++ E + + EE+ E+ P+ P G+ S A + E + N A+
Sbjct: 369 EDEERRERSPEGPREEEAAGGEEESPD--SSPHGE-ASRGAAEPEAQLSNHLAE 419
Score = 38.9 bits (89), Expect = 0.026
Identities = 56/205 (27%), Positives = 83/205 (40%), Gaps = 36/205 (17%)
Query: 146 QPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQ 205
+ ++P G A P P EV +PL A+ GE G A G EA+ EG +
Sbjct: 3 EAAEPEGVAPGP------QGPPEV-PAPL-AERPGEPGAA-GGEAEGP-------EGSEG 46
Query: 206 DASIPSGGRGLSQEGTGPPTSAGEGHSR-TEDAAQELLLPESKGGSSEPGTELQTTEQQA 264
P G + + G G P E +R T A E E++ G+ E Q E+ +
Sbjct: 47 AEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGE---TEAEEGAPEGAEVPQGGEETS 103
Query: 265 GASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAA 324
GA E A+ +GA E + + QR +P + P + +EAE + +
Sbjct: 104 GAQQ-------VEGASPGRGAQGEPRGEAQR--EPEDSAAPERQ--EEAEQRPE-----V 147
Query: 325 EEKVGKNEQGEPEDLKKPEGKNRSA 349
E E G+ D + P G N A
Sbjct: 148 PEGSASGEAGDSVDAEGPLGDNIEA 172
Score = 34.3 bits (77), Expect = 0.64
Identities = 56/230 (24%), Positives = 86/230 (37%), Gaps = 20/230 (8%)
Query: 139 QQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPL--QAQALGEAGVATGSEAQSSPQF 196
+ GP G + G ++ +G + + + PL QA G AG + +E +
Sbjct: 171 EAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSV 230
Query: 197 QDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSE---P 253
EG D+ G G S E P AG+G A + G S + P
Sbjct: 231 D--AEGPAGDSVDAEGRVGDSVEAGDP---AGDGVEAGVPAGDSVEAEGPAGDSMDAEGP 285
Query: 254 GTELQ--TTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ 311
+ + E Q S++ A A A + AG+ E + A P K +
Sbjct: 286 AGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAE-EAEVPGVKGSEE 344
Query: 312 EAETKTKDEMAAAEEKVGKNEQGEP-EDLKK----PEGKNRSAAAVKNEK 356
A + + A E++VG Q EP ED ++ PEG AA E+
Sbjct: 345 AAPGDARAD--AGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEE 392
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 44.3 bits (103), Expect = 6e-04
Identities = 51/230 (22%), Positives = 94/230 (40%), Gaps = 29/230 (12%)
Query: 174 LQAQALGEAGVATGSEAQSSPQFQDHTEG---EDQDASIPSG-GRGLSQEGTGPPTSAGE 229
L A A+G +G ++ P+ + H + + AS+ +G G G S G + + E
Sbjct: 1162 LYALAMGYSGQLKSRKSYMIPENEFHHKDPPPRNAVASVQNGPGGGPSSSSIGSASKSDE 1221
Query: 230 GHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEM 289
+ D ++E S+ G TT + ++ + ++ K GKE
Sbjct: 1222 SSTEETDKSRE----RSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKE- 1276
Query: 290 KEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKK-------- 341
KEK ++ K PATTP + ++ + K K+E +EK + ++ P+ K+
Sbjct: 1277 KEKEKKEKT-PATTPEARVLGKDGKEKPKEERPNKDEKARETKERTPKSDKEKEKFKKEE 1335
Query: 342 -----------PEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVT 380
P +++S + EKE + +E+K+ GG T
Sbjct: 1336 KAKDEKFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKT 1385
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 44.3 bits (103), Expect = 6e-04
Identities = 56/230 (24%), Positives = 87/230 (37%), Gaps = 24/230 (10%)
Query: 145 GQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGED 204
G P++ P E DG+SA + +A L E V + EA + + ED
Sbjct: 63 GPPTESGKQEKAPAE-DGMSAELQG-----EANGLDEVKVESQREAGGKEDAEAELKKED 116
Query: 205 QDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQA 264
+ + G SQE TG R E+ E E K S+ + + E++A
Sbjct: 117 GEKEETTVG---SQEMTG----------RKEETKSEPKEAEEKE-STLASEKQKAEEKEA 162
Query: 265 GASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAA 324
+ DA K +E KT ++ T K E + K DE A A
Sbjct: 163 KPESGQKADANDRDKPEPKATVEEEDAKTASQEE----TGQRKECSTEPKEKATDEEAKA 218
Query: 325 EEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLS 374
E + E + K+P+GK + K E + K + D +E + + S
Sbjct: 219 ESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPS 268
Score = 40.0 bits (92), Expect = 0.012
Identities = 69/317 (21%), Positives = 115/317 (36%), Gaps = 49/317 (15%)
Query: 41 MASASEGEMECGQELKE----------EGGPCLFPGSDSWQENPEEPCSKASWTVQESKK 90
M + GE +C E +E E G + P +D NPE S +E+K
Sbjct: 1 MLPGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAAD----NPE--MSGGGAPAEETKG 54
Query: 91 KKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQP 150
K +G + S + P L +N D SQ + G ++
Sbjct: 55 TAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGL--DEVKVESQREAGGKEDAEAEL 112
Query: 151 PGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDASIP 210
+ DG T VG + + +E + S + + E+++A
Sbjct: 113 K-------KEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPE 165
Query: 211 SGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASM 270
SG + + + P A + A+QE + K S+EP + + T+++A A +
Sbjct: 166 SGQKADANDRDKPEPKATVEEEDAKTASQEET-GQRKECSTEP--KEKATDEEAKAESQK 222
Query: 271 AV---DAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEK 327
AV +A AEP K+P +EA+ K + E A E
Sbjct: 223 AVVEDEAKAEP------------------KEPDGKEEAKHGAKEEADAKEEAEDAEEAEP 264
Query: 328 VGKNEQGEPEDLKKPEG 344
+E+ E + K+PEG
Sbjct: 265 GSPSEEQEQDVEKEPEG 281
Score = 35.4 bits (80), Expect = 0.29
Identities = 39/158 (24%), Positives = 59/158 (37%), Gaps = 16/158 (10%)
Query: 224 PTSAGEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVK 283
P + GE E + + + +G SE GT + S A PA K
Sbjct: 3 PGAVGESDCSAEAREK---MEQKEGKLSEDGTTVSPAADNPEMSGGGA------PAEETK 53
Query: 284 G-AGKEMKE--KTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLK 340
G AGK + E T+ KQ A + + E DE+ ++ ++ +LK
Sbjct: 54 GTAGKAINEGPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELK 113
Query: 341 KPEGKNRSAAAVKNE----KEQKNQEADVQEVKASTLS 374
K +G+ E KE+ E E K STL+
Sbjct: 114 KEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLA 151
>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
Length = 2803
Score = 43.9 bits (102), Expect = 8e-04
Identities = 30/137 (21%), Positives = 68/137 (49%), Gaps = 8/137 (5%)
Query: 239 QELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQ 298
+E++ +K SE EL TE++A S+ + A+P + + +K + +++ +
Sbjct: 338 EEVVEEGAKEARSELAKELAKTEKKAKESSEKPPEKPAKPERVKTESSEALKAEKRKLIK 397
Query: 299 PPATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQ 358
K H +E +K +++ ++K K + E ++LKK EG+ K E+++
Sbjct: 398 DKVG----KKHLKEKISKLEEK----KDKEKKEIKKERKELKKDEGRKEEKKDAKKEEKR 449
Query: 359 KNQEADVQEVKASTLSP 375
K+ + +++++ L P
Sbjct: 450 KDTKPELKKISKPDLKP 466
Score = 35.4 bits (80), Expect = 0.29
Identities = 54/235 (22%), Positives = 69/235 (29%), Gaps = 63/235 (26%)
Query: 10 SKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDS 69
S E T S ER P+ A+ E+ GE++ G E P + S
Sbjct: 2260 SSEATTPVISSVAERFSPSLEAAEQES----------GELDPGME----------PAAHS 2299
Query: 70 -WQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPAS------PCHLTL 122
W P P AS + LA P P PCHL
Sbjct: 2300 LWDLTPLSPAPPASLDLA--------------------LAPAPSLPGDMGDGILPCHLEC 2339
Query: 123 --LSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG 180
+ P +P +GPT PPG A E + +A A
Sbjct: 2340 SEAATEKPSPFQVPSEDCAANGPTETSPNPPGPAPAKAENEEAAA----------CPAWE 2389
Query: 181 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTE 235
G+E S P T + P+GG G P AG TE
Sbjct: 2390 RGAWPEGAERSSRPD----TLLSPEQPVCPAGGSGGPPSSASPEVEAGPQGCATE 2440
Score = 32.0 bits (71), Expect = 3.2
Identities = 57/269 (21%), Positives = 93/269 (34%), Gaps = 47/269 (17%)
Query: 128 PQDTALPHSQAQQSG-PTGQPSQPPGTATTPL-EGDGLSAPTEVGDSPLQAQALGEAGVA 185
P D+A+P + + G P + + P PL E + +S+ T + + +
Sbjct: 789 PADSAVPATSGKVYGTPETELTYPTNIVAAPLAEEEHVSSATSITECDKLSSFATSVAED 848
Query: 186 TGSEAQSSPQFQDHTEGE---DQDASIPSGGRGLSQ-------EGTGPPTSA-------- 227
+ ++PQ ++ + D SIPS +Q GT PTS+
Sbjct: 849 QSVASLTAPQTEETGKSSLLLDTVTSIPSSRTEATQGLDYVPSAGTISPTSSLEEDKGFK 908
Query: 228 ----------GEGHSRTEDAAQELLLPESKGGSSEPGTELQTTEQ---QAGASASMAVDA 274
GE R E + L + E ++ +E+ Q G A
Sbjct: 909 SPPCEDFSVTGESEKRGEIIGKGLSGERAVEEEEEETANVEMSEKLCSQYGTPVFSAPGH 968
Query: 275 VAEPANAVKGAGKEM----KEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKVGK 330
P G +E + T +M PP + PP TH T + EEK
Sbjct: 969 ALHPGEPALGEAEERCLSPDDSTVKMASPPPSGPPSATH-------TPFHQSPVEEKSEP 1021
Query: 331 NEQGEPE---DLKKPEGKNRSAAAVKNEK 356
+ E + D K+ G + AA + K
Sbjct: 1022 QDFQEADSWGDTKRTPGVGKEDAAEETVK 1050
Score = 30.8 bits (68), Expect = 7.1
Identities = 61/272 (22%), Positives = 100/272 (36%), Gaps = 43/272 (15%)
Query: 86 QESKKKKRKKKKKGNKSASSELASLPLSPASP-CHLTLLSNPWPQDTALPHSQAQQSGPT 144
+E K K+++K+K K +++ L P +P TL P + S+A + G
Sbjct: 438 EEKKDAKKEEKRKDTKPELKKISKPDLKPFTPEVRKTLYKAKVPGRVKIDRSRAIR-GEK 496
Query: 145 GQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTE--- 201
S+P TP P + G PL + G + S + F++
Sbjct: 497 ELSSEP----QTP--------PAQKGTVPLPTIS-GHRELVLSSPEDLTQDFEEMKREER 543
Query: 202 ---GEDQDASIPSGGRGLSQEGTGPPTSAGEG-HSRTEDAAQELLLPESKGGSSEPGTEL 257
E +D + L GPP++A +G QE + + K EL
Sbjct: 544 ALLAEQRDTGLGDKPFPLDTAEEGPPSTAIQGTPPSVPGLGQEEHVMKEK--------EL 595
Query: 258 QTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHC-QEAETK 316
+ S +D+ AE +E K+ + KQ A P +T +E+E +
Sbjct: 596 VPEVPEEQGSKDRGLDSGAET--------EEEKDTWEEKKQREAERLPDRTEAREESEPE 647
Query: 317 TKDEMAAAEEKVGKNE----QGEPEDLKKPEG 344
K+++ E E E ED K EG
Sbjct: 648 VKEDVIEKAELEEMEEVHPSDEEEEDATKAEG 679
>gi|19923084 polycystin-1L1 [Homo sapiens]
Length = 2849
Score = 43.9 bits (102), Expect = 8e-04
Identities = 50/171 (29%), Positives = 67/171 (39%), Gaps = 22/171 (12%)
Query: 99 GNKSASSELASLPLSP--ASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQP-PGTAT 155
G S SS+L LP P A P T + P L Q S P G P++P G
Sbjct: 961 GAISESSQLNLLPTEPGTADPDATTTPFSREPSPVTL--GQPATSAPRGTPTEPMTGVYW 1018
Query: 156 TPLEGDG--LSAPTEVGDSPLQAQALGEAGVATGSEAQSSPQFQDHTEGEDQDA------ 207
P GD L E G L+ + + TG +S P D +A
Sbjct: 1019 IPPAGDSAVLGEAPEEGSLDLEPGPQSKGSLMTGRSERSQPTHSPDPHLSDFEAYYSDIQ 1078
Query: 208 -SIPSGGRGLSQE----GTGPPTSAGEGHSRTEDAAQELLLPESKGGSSEP 253
+IPSGGR +++ G+GP SA E + L+ P G +EP
Sbjct: 1079 EAIPSGGRQPAKDTSFPGSGPSLSAEE----SPGDGDNLVDPSLSAGRAEP 1125
>gi|120587027 ubiquitin specific peptidase 31 [Homo sapiens]
Length = 1352
Score = 43.1 bits (100), Expect = 0.001
Identities = 80/380 (21%), Positives = 129/380 (33%), Gaps = 60/380 (15%)
Query: 22 GERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGGPCLFPGSDSWQENPEE----- 76
G+RLPP + D NN+ +A + + +KE P PGS + + PE
Sbjct: 973 GDRLPPLSGPFD---NNNQIAYVDQSDSVDSSPVKEVKAPS-HPGSLA--KKPESTTKRS 1026
Query: 77 PCSKASWTVQESKKKKRKKKKKGNKSASSELASLPL------------------------ 112
P SK + ++S +K R S SS S PL
Sbjct: 1027 PSSKGTSEPEKSLRKGRPALASQESSLSSTSPSSPLPVKVSLKPSRSRSKADSSSRGSGR 1086
Query: 113 -SPASPCHLTLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGD 171
S +P S+P QD+ S +Q + T+ G +P G
Sbjct: 1087 HSSPAPAQPKKESSPKSQDSVSSPSPQKQKSASALTYTASSTSAKKASGPATRSPFPPGK 1146
Query: 172 SPLQAQALGEAG----------VATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGT 221
S +L G AT + +SP+ GE + A ++
Sbjct: 1147 SRTSDHSLSREGSRQSLGSDRASATSTSKPNSPRVSQARAGEGRGAGKHVRSSSMASL-R 1205
Query: 222 GPPTSAGEG---HSRTEDAAQELLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEP 278
P TS G S++ED + + T+L T + + +V +V
Sbjct: 1206 SPSTSIKSGLKRDSKSEDKGLSFFKSALRQKETRRSTDLGKTALLSKKAGGSSVKSVC-- 1263
Query: 279 ANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDEMAAAEEKV-GKNEQGEPE 337
K G ++ +R QPPA+ P + + TKD +A + + +
Sbjct: 1264 ----KNTG---DDEAERGHQPPASQQPNANTTGKEQLVTKDPASAKHSLLSARKSKSSQL 1316
Query: 338 DLKKPEGKNRSAAAVKNEKE 357
D P +A K+ K+
Sbjct: 1317 DSGVPSSPGGRQSAEKSSKK 1336
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,106,910
Number of Sequences: 37866
Number of extensions: 2392037
Number of successful extensions: 11322
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 526
Number of HSP's that attempted gapping in prelim test: 10001
Number of HSP's gapped (non-prelim): 1635
length of query: 1063
length of database: 18,247,518
effective HSP length: 113
effective length of query: 950
effective length of database: 13,968,660
effective search space: 13270227000
effective search space used: 13270227000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.