Search of human proteins with 66267730

Search of human proteins with 66267730

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|66267730 WD repeat domain 34 [Homo sapiens]
         (536 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|66267730 WD repeat domain 34 [Homo sapiens]                       1085   0.0  
gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens]              116   5e-26
gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo ...   110   2e-24
gi|24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo sa...   104   2e-22
gi|4758178 dynein, cytoplasmic 1, intermediate chain 1 isoform a...    99   7e-21
gi|207113124 dynein, cytoplasmic 1, intermediate chain 1 isoform...    99   7e-21
gi|207113122 dynein, cytoplasmic 1, intermediate chain 1 isoform...    99   7e-21
gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]       89   1e-17
gi|155030242 WD repeat domain 60 [Homo sapiens]                        62   1e-09
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      50   4e-06
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    50   7e-06
gi|55741849 WD repeat domain 22 [Homo sapiens]                         49   2e-05
gi|14149987 WD repeat domain 24 [Homo sapiens]                         49   2e-05
gi|14149696 SEC31 homolog B [Homo sapiens]                             48   2e-05
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          47   3e-05
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          47   3e-05
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          47   3e-05
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            47   3e-05
gi|19913367 transducin beta-like 1Y [Homo sapiens]                     45   2e-04
gi|19913365 transducin beta-like 1Y [Homo sapiens]                     45   2e-04
gi|15150805 transducin beta-like 1Y [Homo sapiens]                     45   2e-04
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             45   2e-04
gi|217272887 WD repeat domain 63 [Homo sapiens]                        44   3e-04
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    43   6e-04
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    43   6e-04
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    43   6e-04
gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens]                  43   6e-04
gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens]                  43   6e-04
gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens]                  43   6e-04
gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens]                   43   6e-04

>gi|66267730 WD repeat domain 34 [Homo sapiens]
          Length = 536

 Score = 1085 bits (2807), Expect = 0.0
 Identities = 536/536 (100%), Positives = 536/536 (100%)

Query: 1   MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRW 60
           MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRW
Sbjct: 1   MATRAQPGPLSQAGSAGVAALATVGVASGPGPGRPGPLQDETLGVASVPSQWRAVQGIRW 60

Query: 61  ETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVI 120
           ETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVI
Sbjct: 61  ETKSCQTASIATASASAQARNHVDAQVQTEAPVPVSVQPPSQYDIPRLAAFLRRVEAMVI 120

Query: 121 RELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAY 180
           RELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAY
Sbjct: 121 RELNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVACAY 180

Query: 181 GRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSG 240
           GRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSG
Sbjct: 181 GRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSG 240

Query: 241 EVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQG 300
           EVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQG
Sbjct: 241 EVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQG 300

Query: 301 IGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPL 360
           IGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPL
Sbjct: 301 IGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPL 360

Query: 361 KCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY 420
           KCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY
Sbjct: 361 KCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY 420

Query: 421 SMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQ 480
           SMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQ
Sbjct: 421 SMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQ 480

Query: 481 DESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA 536
           DESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA
Sbjct: 481 DESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLAAEVAA 536


>gi|46276887 WD repeat domain 78 isoform 1 [Homo sapiens]
          Length = 848

 Score =  116 bits (291), Expect = 5e-26
 Identities = 93/369 (25%), Positives = 163/369 (44%), Gaps = 47/369 (12%)

Query: 160 QGLHVTSISWNSTG-SVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPS 218
           +GL+V+S++WN T   ++A  YG    G     +   C W++      P  P  + + P 
Sbjct: 484 KGLNVSSLAWNKTNPDLLAVGYGHF--GFKEQKRGLACCWSIKN----PMWPERIYQSPY 537

Query: 219 AVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEP 278
            V  + F    P+ +A G ++G + ++++    +  +  +  +   H  PV Q+ W+ + 
Sbjct: 538 GVTAVDFSIGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSSESPQKHLGPVWQLQWIEQD 597

Query: 279 ----GHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALV-MQQLPRSTKLKKHPRGET 333
               G   R  ++S++ DG++  W         + +G     + +L R+T       GE 
Sbjct: 598 RGTTGDGKREILVSISADGRISKWV--------IRKGLDCYDLMRLKRTTAASNKKGGEK 649

Query: 334 EVGATAV----------AFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAP 383
           E    A+          AF   D  +++ GTE G   KCS +  E  L            
Sbjct: 650 EKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIHKCSCSYNEQYLD----------- 698

Query: 384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRW 443
              T+  H GP+Y V+ +PF  ++FLS   D  V ++      P  S   +   ++ V W
Sbjct: 699 ---TYRGHKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAW 755

Query: 444 SPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDA 503
           SP    +FAAA+ +  V+++DL  S+  P  LI  T +    +     ++QT  L  GD+
Sbjct: 756 SPKSSYIFAAAN-ENRVEIWDLHISTLDP--LIVNTANPGIKFTTILFAKQTDCLLVGDS 812

Query: 504 QGTVKVWQL 512
            G V V++L
Sbjct: 813 DGQVSVYEL 821


>gi|217416452 dynein, axonemal, intermediate polypeptide 2 [Homo
           sapiens]
          Length = 605

 Score =  110 bits (276), Expect = 2e-24
 Identities = 92/352 (26%), Positives = 157/352 (44%), Gaps = 38/352 (10%)

Query: 165 TSISWNSTGS-VVACAYGRLDHGDWST-LKSFVCAWNLDRRDLRPQQPSAVVEVPSAVLC 222
           T +SW+  G+  +A AY  LD       + S    W+L+     P +P   ++  S ++ 
Sbjct: 166 THLSWHPDGNRKLAVAYSCLDFQRAPVGMSSDSYIWDLEN----PNKPELALKPSSPLVT 221

Query: 223 LAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSH 282
           L F+P     + GG Y+G++  WD  +    L+      + +H DPV   +WL     + 
Sbjct: 222 LEFNPKDSHVLLGGCYNGQIACWDTRK--GSLVAELSTIESSHRDPVYGTIWLQSKTGTE 279

Query: 283 RFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAF 342
            F   S +TDG+V+ W        +++E   +V+  + +  +L      E  +GA ++ F
Sbjct: 280 CF---SASTDGQVMWWD-----IRKMSEPTEVVILDITKKEQL------ENALGAISLEF 325

Query: 343 SSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSP 402
            S  P  F++GTE G  + C+  A  +A                TF  H GPIY++  +P
Sbjct: 326 ESTLPTKFMVGTEQGIVISCNRKAKTSA-----------EKIVCTFPGHHGPIYALQRNP 374

Query: 403 FHRNLFLSAGTDGHVHLYSM-LQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQ 461
           F+   FL+ G D    ++S   +   +   +  + YL    WSPVRP VF      G + 
Sbjct: 375 FYPKNFLTVG-DWTARIWSEDSRESSIMWTKYHMAYLTDAAWSPVRPTVFFTTRMDGTLD 433

Query: 462 LFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQLS 513
           ++D       PT+ +K    +  ++CL        L+A G   GT  + ++S
Sbjct: 434 IWDFMFEQCDPTLSLKVC--DEALFCLRVQDNGC-LIACGSQLGTTTLLEVS 482


>gi|24307879 dynein, cytoplasmic 1, intermediate chain 2 [Homo
           sapiens]
          Length = 638

 Score =  104 bits (259), Expect = 2e-22
 Identities = 80/323 (24%), Positives = 143/323 (44%), Gaps = 41/323 (12%)

Query: 198 WNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWR 257
           WN+  +   P+    V    SAV+   F    P+ V GG YSG++++WD    +   + R
Sbjct: 316 WNMKYKKTTPEY---VFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQR 372

Query: 258 TGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQ 317
           T L+   HT PV  V  +   G  +   ++S++TDGK+  W              +L M 
Sbjct: 373 TPLSAAAHTHPVYCVNVV---GTQNAHNLISISTDGKICSW--------------SLDML 415

Query: 318 QLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSS 377
             P+ +    H + +  V  T+++F   D   F++G+E G          +A ++ M   
Sbjct: 416 SHPQDSMELVHKQSKA-VAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEM--- 471

Query: 378 VPLRAPAQFTFSPHGGPIYSVSCSPF-----HRNLFLSAGTDGHVHLYSMLQAPPLTSLQ 432
                     F  H GPI  + C          +LF+++  D  V L++     PL S +
Sbjct: 472 ----------FEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFE 521

Query: 433 LSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNS 492
            +  Y++ V WSP  P +FA   G G + L++L   ++ PT  I  + + +P       +
Sbjct: 522 DNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASI--SVEGNPALNRVRWT 579

Query: 493 QQTQLLAAGDAQGTVKVWQLSTE 515
              + +A GD++G + ++ +  +
Sbjct: 580 HSGREIAVGDSEGQIVIYDVGEQ 602


>gi|4758178 dynein, cytoplasmic 1, intermediate chain 1 isoform a
           [Homo sapiens]
          Length = 645

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 80/320 (25%), Positives = 146/320 (45%), Gaps = 41/320 (12%)

Query: 198 WNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWR 257
           WN+  +   P+    V    S+V+ + F    P+ V GG YSG++++WD        + R
Sbjct: 324 WNMKFKKTTPEY---VFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQR 380

Query: 258 TGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQ 317
           T L+   HT PV  V  +   G  +   +++V+TDGK+  W              +L M 
Sbjct: 381 TPLSAAAHTHPVYCVNVV---GTQNAHNLITVSTDGKMCSW--------------SLDML 423

Query: 318 QLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSS 377
             P+ +    + + +  V  T +AF + D   F++G+E G          +A +  +   
Sbjct: 424 STPQESMELVYNKSKP-VAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEV--- 479

Query: 378 VPLRAPAQFTFSPHGGPIYSVSC----SPFH-RNLFLSAGTDGHVHLYSMLQAPPLTSLQ 432
                     F  H GP+  ++C     P    +LF+++  D  V L++     PL S +
Sbjct: 480 ----------FEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFE 529

Query: 433 LSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNS 492
            +  Y++ V WSPV P +FA   G G + L++L   ++ PT  +   +  S +  + + +
Sbjct: 530 DNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASV-AIEGASALNRVRW-A 587

Query: 493 QQTQLLAAGDAQGTVKVWQL 512
           Q  + +A GD++G + V+ +
Sbjct: 588 QAGKEVAVGDSEGRIWVYDV 607


>gi|207113124 dynein, cytoplasmic 1, intermediate chain 1 isoform c
           [Homo sapiens]
          Length = 608

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 80/320 (25%), Positives = 146/320 (45%), Gaps = 41/320 (12%)

Query: 198 WNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWR 257
           WN+  +   P+    V    S+V+ + F    P+ V GG YSG++++WD        + R
Sbjct: 287 WNMKFKKTTPEY---VFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQR 343

Query: 258 TGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQ 317
           T L+   HT PV  V  +   G  +   +++V+TDGK+  W              +L M 
Sbjct: 344 TPLSAAAHTHPVYCVNVV---GTQNAHNLITVSTDGKMCSW--------------SLDML 386

Query: 318 QLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSS 377
             P+ +    + + +  V  T +AF + D   F++G+E G          +A +  +   
Sbjct: 387 STPQESMELVYNKSKP-VAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEV--- 442

Query: 378 VPLRAPAQFTFSPHGGPIYSVSC----SPFH-RNLFLSAGTDGHVHLYSMLQAPPLTSLQ 432
                     F  H GP+  ++C     P    +LF+++  D  V L++     PL S +
Sbjct: 443 ----------FEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFE 492

Query: 433 LSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNS 492
            +  Y++ V WSPV P +FA   G G + L++L   ++ PT  +   +  S +  + + +
Sbjct: 493 DNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASV-AIEGASALNRVRW-A 550

Query: 493 QQTQLLAAGDAQGTVKVWQL 512
           Q  + +A GD++G + V+ +
Sbjct: 551 QAGKEVAVGDSEGRIWVYDV 570


>gi|207113122 dynein, cytoplasmic 1, intermediate chain 1 isoform b
           [Homo sapiens]
          Length = 628

 Score = 99.4 bits (246), Expect = 7e-21
 Identities = 80/320 (25%), Positives = 146/320 (45%), Gaps = 41/320 (12%)

Query: 198 WNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWR 257
           WN+  +   P+    V    S+V+ + F    P+ V GG YSG++++WD        + R
Sbjct: 307 WNMKFKKTTPEY---VFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQR 363

Query: 258 TGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFALVMQ 317
           T L+   HT PV  V  +   G  +   +++V+TDGK+  W              +L M 
Sbjct: 364 TPLSAAAHTHPVYCVNVV---GTQNAHNLITVSTDGKMCSW--------------SLDML 406

Query: 318 QLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSS 377
             P+ +    + + +  V  T +AF + D   F++G+E G          +A +  +   
Sbjct: 407 STPQESMELVYNKSKP-VAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEV--- 462

Query: 378 VPLRAPAQFTFSPHGGPIYSVSC----SPFH-RNLFLSAGTDGHVHLYSMLQAPPLTSLQ 432
                     F  H GP+  ++C     P    +LF+++  D  V L++     PL S +
Sbjct: 463 ----------FEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFE 512

Query: 433 LSLKYLFAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNS 492
            +  Y++ V WSPV P +FA   G G + L++L   ++ PT  +   +  S +  + + +
Sbjct: 513 DNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASV-AIEGASALNRVRW-A 570

Query: 493 QQTQLLAAGDAQGTVKVWQL 512
           Q  + +A GD++G + V+ +
Sbjct: 571 QAGKEVAVGDSEGRIWVYDV 590


>gi|6912338 dynein, axonemal, intermediate chain 1 [Homo sapiens]
          Length = 699

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 82/315 (26%), Positives = 134/315 (42%), Gaps = 38/315 (12%)

Query: 158 QAQGLHVTSISWNST-GSVVACAYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEV 216
           +A+ L VT++ WN     + A  YG  D    S  +  +  ++L      P  P  +   
Sbjct: 329 KAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQS--RGMLLLYSLKN----PSFPEYMFSS 382

Query: 217 PSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLP 276
            S V+CL  H   P  VA G Y G V +++L +      + +      H+DPV QV W  
Sbjct: 383 NSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQPSFCSSAKSGKHSDPVWQVKW-Q 441

Query: 277 EPGHSHRFQVLSVATDGKVLLW-----QGIGVGQLQL-TEGFALVMQQLPRSTKLKKHPR 330
           +          SV++DG+++ W     + + +  ++L  EG      ++P   +L  HP 
Sbjct: 442 KDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGST---TEVPEGLQL--HPV 496

Query: 331 GETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSP 390
           G      TA  F      +F++GTE G   KCS +     L               T+  
Sbjct: 497 G----CGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLD--------------TYDA 538

Query: 391 HGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLV 450
           H   + +VS +P+H  +F+S  +D  V ++      P+    L+   +  V W+P    V
Sbjct: 539 HNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLN-SAVGDVAWAPYSSTV 597

Query: 451 FAAASGKGDVQLFDL 465
           FAA +  G   +FDL
Sbjct: 598 FAAVTTDGKAHIFDL 612


>gi|155030242 WD repeat domain 60 [Homo sapiens]
          Length = 1066

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 103/433 (23%), Positives = 161/433 (37%), Gaps = 89/433 (20%)

Query: 104 DIPRLAAFLR---RVEAMVIRE----LNKNWQSHAFDGFEVNWTEQQQMVSCLYTLGYPP 156
           D PRL +FLR   +V A+++ E       +W   A D          Q+ + L  L    
Sbjct: 584 DTPRLCSFLRAACQVMAVLLEEDRLAAEPSWNLRAQDRALYFSDSSSQLNTSLPFL---- 639

Query: 157 AQAQGLHVTSISWNSTGSVVACAYGRLDHGDWSTL---KSFVCAWNLDRRDLRPQQPSAV 213
              Q   V+S+  +     +  +   L    +  L   K  +C W++     +P  P  V
Sbjct: 640 ---QNRKVSSLHTSRVQRQMVVSVHDLPEKSFVPLLDSKYVLCVWDI----WQPSGPQKV 692

Query: 214 VEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDL---SRLEDPLLWRTG----------- 259
           +   S V C    P +   +  G   G V+VWDL   SRL   +    G           
Sbjct: 693 LICESQVTCCCLSPLKAFLLFAGTAHGSVVVWDLREDSRLHYSVTLSDGFWTFRTATFST 752

Query: 260 ---LTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEGFAL-- 314
              LT   H  P+  V  +    H  +  VLS  +  + +   G+      L E   L  
Sbjct: 753 DGILTSVNHRSPLQAVEPISTSVHKKQSFVLSPFSTQEEM--SGLSFHIASLDESGVLNV 810

Query: 315 -VMQQLPRS------TKLKKHPRGETEVGATA-----------------------VAFSS 344
            V+ +LP++      + L   P G  ++  +A                       V F  
Sbjct: 811 WVVVELPKADIAGSISDLGLMPGGRVKLVHSALIQLGDSLSHKGNEFWGTTQTLNVKFLP 870

Query: 345 FDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHG---GPIYSVSCS 401
            DP  FI+GT+ G      ++ G    TR    V   AP  F    HG     +  +  S
Sbjct: 871 SDPNHFIIGTDMGL-----ISHG----TRQDLRV---APKLFKPQQHGIRPVKVNVIDFS 918

Query: 402 PFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKY--LFAVRWSPVRPLVFAAASGKGD 459
           PF   +FL+  +DG + L+ +  A PL     S     +  ++WSP RP VF       +
Sbjct: 919 PFGEPIFLAGCSDGSIRLHQLSSAFPLLQWDSSTDSHAVTGLQWSPTRPAVFLVQDDTSN 978

Query: 460 VQLFDLQKSSQKP 472
           + ++DL +S   P
Sbjct: 979 IYIWDLLQSDLGP 991


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 50.4 bits (119), Expect = 4e-06
 Identities = 32/134 (23%), Positives = 64/134 (47%), Gaps = 11/134 (8%)

Query: 386 FTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSM-------LQAPPLTSLQLSLKYL 438
           F+F+ H G  +++  SP      L+     ++HL++        +   P      S++ L
Sbjct: 208 FSFAGHMGEGFALDWSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDL 267

Query: 439 FAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
              +WSP    VFA+ S    ++++D++ +  K  +L   T  +  V  + ++ ++  LL
Sbjct: 268 ---QWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLL 324

Query: 499 AAGDAQGTVKVWQL 512
           + GD  G +K+W L
Sbjct: 325 SGGD-DGALKIWDL 337



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 36/147 (24%), Positives = 63/147 (42%), Gaps = 9/147 (6%)

Query: 385 QFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPP----LTSLQLSLKYLFA 440
           Q  F  H   +  +  SP    +F S   D  + ++ +  AP     LT+       +  
Sbjct: 254 QRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNV 313

Query: 441 VRWSPVRPLVFAAASGKGDVQLFDLQK-SSQKPTVLIKQTQDESPVYCLEFNSQQTQLLA 499
           + WS   P + +     G ++++DL++  S  P    KQ    +PV  +E++ Q + + A
Sbjct: 314 ISWSRREPFLLSGGDD-GALKIWDLRQFKSGSPVATFKQ--HVAPVTSVEWHPQDSGVFA 370

Query: 500 AGDAQGTVKVWQLSTE-FTEQGPREAE 525
           A  A   +  W L+ E   E G  EA+
Sbjct: 371 ASGADHQITQWDLAVERDPEAGDVEAD 397


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 49.7 bits (117), Expect = 7e-06
 Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 14/136 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P   NL  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 344 TFQGHTNEVNAIKWDPTG-NLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPT 402

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        L+ A+AS    V+L+D+ +     T+    T+ + PVY + F S   + L
Sbjct: 403 GPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTL----TKHQEPVYSVAF-SPDGRYL 457

Query: 499 AAGDAQGTVKVWQLST 514
           A+G     V +W   T
Sbjct: 458 ASGSFDKCVHIWNTQT 473



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 41/157 (26%), Positives = 62/157 (39%), Gaps = 17/157 (10%)

Query: 364 LAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
           L+AG    T +  +    A  QF F  H  P   V       N F S  TD  +H+  + 
Sbjct: 282 LSAGVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQS--NNTFASCSTDMCIHVCKLG 337

Query: 424 QAPPLTSLQLSLKYLFAVRWSPVRPLVFAAA--------SGKGDVQLFDLQKSSQKPTVL 475
           Q  P+ + Q     + A++W P   L+ + +        S K D  + DLQ +  K    
Sbjct: 338 QDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQ-AHNKEIYT 396

Query: 476 IKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQL 512
           IK     SP      N     +LA+     TV++W +
Sbjct: 397 IKW----SPTGPGTNNPNANLMLASASFDSTVRLWDV 429


>gi|55741849 WD repeat domain 22 [Homo sapiens]
          Length = 942

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 54/216 (25%), Positives = 88/216 (40%), Gaps = 36/216 (16%)

Query: 286 VLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRSTKLKKHPRGETEVGATAVAFSSF 345
           ++S   D +VLLW                 M+Q   S       +GE       +AF+S 
Sbjct: 69  LVSGGDDRRVLLWH----------------MEQAIHSRVKPIQLKGEHHSNIFCLAFNSG 112

Query: 346 DPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHR 405
           + ++F  G +            +  L  + SS  L   A      H   +Y +S SP + 
Sbjct: 113 NTKVFSGGNDE-----------QVILHDVESSETLDVFA------HEDAVYGLSVSPVND 155

Query: 406 NLFLSAGTDGHVHLYSMLQAPPLTSLQLS--LKYLFAVRWSPVRPLVFAAASGKGDVQLF 463
           N+F S+  DG V ++ + ++P      L+       +V ++PV P + A A+ K  V L+
Sbjct: 156 NIFASSSDDGRVLIWDIRESPHGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLW 215

Query: 464 DLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLA 499
           D++K  Q   +             + FNS  TQLLA
Sbjct: 216 DIRK-PQSSLLRYGGNLSLQSAMSVRFNSNGTQLLA 250


>gi|14149987 WD repeat domain 24 [Homo sapiens]
          Length = 790

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/136 (22%), Positives = 61/136 (44%), Gaps = 3/136 (2%)

Query: 379 PLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYL 438
           P R      F+ H   +  V   P   ++ LS   DG +  + + +   +++     + +
Sbjct: 107 PSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESV 166

Query: 439 FAVRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
             V++S      FA+    G+VQL+D+++  +   +    T    PV+C +++ +    L
Sbjct: 167 RDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMF---TAHNGPVFCCDWHPEDRGWL 223

Query: 499 AAGDAQGTVKVWQLST 514
           A G     VKVW ++T
Sbjct: 224 ATGGRDKMVKVWDMTT 239


>gi|14149696 SEC31 homolog B [Homo sapiens]
          Length = 1179

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 63/254 (24%), Positives = 97/254 (38%), Gaps = 42/254 (16%)

Query: 219 AVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEP 278
           AV  L  +P Q + +A G    E+ +WDL+ L  P+    G       + +  + W  + 
Sbjct: 123 AVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMT--LGSKSQQPPEDIKALSWNRQA 180

Query: 279 GHSHRFQVLSVA-TDGKVLLWQGIGVGQLQLTEGFALVMQQLPRS--TKLKKHPRGETEV 335
            H     +LS A   GK ++W       L+  E    V     R   + L  HP      
Sbjct: 181 QH-----ILSSAHPSGKAVVWD------LRKNEPIIKVSDHSNRMHCSGLAWHPDI---- 225

Query: 336 GATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPI 395
            AT +   S D RL ++               +    R  SS PL+         H   I
Sbjct: 226 -ATQLVLCSEDDRLPVI---------------QLWDLRFASS-PLKV-----LESHSRGI 263

Query: 396 YSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAAS 455
            SVS S     L L++  D  +   ++  +  +  L     + F V+W P  P VF+AAS
Sbjct: 264 LSVSWSQADAELLLTSAKDSQILCRNLGSSEVVYKLPTQSSWCFDVQWCPRDPSVFSAAS 323

Query: 456 GKGDVQLFDLQKSS 469
             G + L+ +   S
Sbjct: 324 FNGWISLYSVMGRS 337



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 26/131 (19%), Positives = 57/131 (43%), Gaps = 13/131 (9%)

Query: 391 HGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSM--LQAPPL--TSLQLSLKYLFAVRWSPV 446
           H G + ++  +PF  NL  S  +D  + ++ +  L  P    +  Q   + + A+ W+  
Sbjct: 120 HTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQPPEDIKALSWNRQ 179

Query: 447 RPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFN-----SQQTQLLAAG 501
              + ++A   G   ++DL+K+      +IK +   + ++C         + Q  L +  
Sbjct: 180 AQHILSSAHPSGKAVVWDLRKNEP----IIKVSDHSNRMHCSGLAWHPDIATQLVLCSED 235

Query: 502 DAQGTVKVWQL 512
           D    +++W L
Sbjct: 236 DRLPVIQLWDL 246


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 356 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T+    T+ + PVY + F S   + L
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL----TKHQEPVYSVAF-SPDGKYL 469

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 470 ASGSFDKCVHIW 481


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 356 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 414

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T+    T+ + PVY + F S   + L
Sbjct: 415 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL----TKHQEPVYSVAF-SPDGKYL 469

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 470 ASGSFDKCVHIW 481


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 407 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T+    T+ + PVY + F S   + L
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL----TKHQEPVYSVAF-SPDGKYL 520

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 521 ASGSFDKCVHIW 532


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 35/132 (26%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 407 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPT 465

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T+    T+ + PVY + F S   + L
Sbjct: 466 GPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTL----TKHQEPVYSVAF-SPDGKYL 520

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 521 ASGSFDKCVHIW 532


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 34/132 (25%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 354 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T++    + + PVY + F S   + L
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLM----KHQEPVYSVAF-SPDGKYL 467

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 468 ASGSFDKYVHIW 479



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 40/157 (25%), Positives = 62/157 (39%), Gaps = 17/157 (10%)

Query: 364 LAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
           L+AG    T +  +    A  QF F  H  P   V     +   F S  TD  +H+  + 
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQ--NNMTFASCSTDMCIHVCRLG 347

Query: 424 QAPPLTSLQLSLKYLFAVRWSPVRPLVFAAA--------SGKGDVQLFDLQKSSQKPTVL 475
              P+ + Q     + A++W P   L+ + +        S K D  + DLQ  S K    
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS-KEIYT 406

Query: 476 IKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQL 512
           IK     SP      N   + +LA+     TV++W +
Sbjct: 407 IKW----SPTGPATSNPNSSIMLASASFDSTVRLWDV 439


>gi|19913365 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 34/132 (25%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 354 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T++    + + PVY + F S   + L
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLM----KHQEPVYSVAF-SPDGKYL 467

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 468 ASGSFDKYVHIW 479



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 40/157 (25%), Positives = 62/157 (39%), Gaps = 17/157 (10%)

Query: 364 LAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
           L+AG    T +  +    A  QF F  H  P   V     +   F S  TD  +H+  + 
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQ--NNMTFASCSTDMCIHVCRLG 347

Query: 424 QAPPLTSLQLSLKYLFAVRWSPVRPLVFAAA--------SGKGDVQLFDLQKSSQKPTVL 475
              P+ + Q     + A++W P   L+ + +        S K D  + DLQ  S K    
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS-KEIYT 406

Query: 476 IKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQL 512
           IK     SP      N   + +LA+     TV++W +
Sbjct: 407 IKW----SPTGPATSNPNSSIMLASASFDSTVRLWDV 439


>gi|15150805 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 34/132 (25%), Positives = 61/132 (46%), Gaps = 14/132 (10%)

Query: 387 TFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPV 446
           TF  H   + ++   P    L  S   D  + ++SM Q   +  LQ   K ++ ++WSP 
Sbjct: 354 TFQGHTNEVNAIKWDPSGM-LLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPT 412

Query: 447 RP--------LVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLL 498
            P        ++ A+AS    V+L+D+++     T++    + + PVY + F S   + L
Sbjct: 413 GPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLM----KHQEPVYSVAF-SPDGKYL 467

Query: 499 AAGDAQGTVKVW 510
           A+G     V +W
Sbjct: 468 ASGSFDKYVHIW 479



 Score = 32.3 bits (72), Expect = 1.1
 Identities = 40/157 (25%), Positives = 62/157 (39%), Gaps = 17/157 (10%)

Query: 364 LAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
           L+AG    T +  +    A  QF F  H  P   V     +   F S  TD  +H+  + 
Sbjct: 292 LSAGVDKTTIIWDAHTGEAKQQFPF--HSAPALDVDWQ--NNMTFASCSTDMCIHVCRLG 347

Query: 424 QAPPLTSLQLSLKYLFAVRWSPVRPLVFAAA--------SGKGDVQLFDLQKSSQKPTVL 475
              P+ + Q     + A++W P   L+ + +        S K D  + DLQ  S K    
Sbjct: 348 CDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHS-KEIYT 406

Query: 476 IKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQL 512
           IK     SP      N   + +LA+     TV++W +
Sbjct: 407 IKW----SPTGPATSNPNSSIMLASASFDSTVRLWDV 439


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 45/194 (23%), Positives = 79/194 (40%), Gaps = 21/194 (10%)

Query: 128 QSHAFDGFEVNWTEQ---------QQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVAC 178
           + H  +G+ ++W                 CL+ +   P + + +   +I    +  V   
Sbjct: 173 RGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDV 232

Query: 179 AYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSA-VLCLAFHPTQPSHVAGGL 237
           A+  L    + ++         D R     +PS +V+  +A V CL+F+P     +A G 
Sbjct: 233 AWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGS 292

Query: 238 YSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVL-SVATDGKVL 296
               V +WDL  L+  L      T ++H D + QV W P     H   +L S  TD ++ 
Sbjct: 293 ADKTVALWDLRNLKLKL-----HTFESHKDEIFQVHWSP-----HNETILASSGTDRRLN 342

Query: 297 LWQGIGVGQLQLTE 310
           +W    +G+ Q  E
Sbjct: 343 VWDLSKIGEEQSAE 356



 Score = 36.6 bits (83), Expect = 0.059
 Identities = 32/146 (21%), Positives = 60/146 (41%), Gaps = 6/146 (4%)

Query: 384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY---SMLQAPPLTSLQLSLKYLFA 440
           A+  F+ H   +  V+    H +LF S   D  + ++   S   + P   +      +  
Sbjct: 218 AKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNC 277

Query: 441 VRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAA 500
           + ++P    + A  S    V L+DL+    K     +  +DE  ++ + ++     +LA+
Sbjct: 278 LSFNPYSEFILATGSADKTVALWDLRNLKLKLHTF-ESHKDE--IFQVHWSPHNETILAS 334

Query: 501 GDAQGTVKVWQLSTEFTEQGPREAED 526
                 + VW LS    EQ   +AED
Sbjct: 335 SGTDRRLNVWDLSKIGEEQSAEDAED 360



 Score = 35.4 bits (80), Expect = 0.13
 Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 12/113 (10%)

Query: 409 LSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFA--------VRWSPVRPLVFAAASGKGDV 460
           LSA  D  V L+  + A P     +  K +F         V W  +   +F + +    +
Sbjct: 193 LSASDDHTVCLWD-INAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251

Query: 461 QLFDLQKSS-QKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQL 512
            ++D + ++  KP+ L+     E  V CL FN     +LA G A  TV +W L
Sbjct: 252 MIWDTRSNTTSKPSHLVDAHTAE--VNCLSFNPYSEFILATGSADKTVALWDL 302



 Score = 32.7 bits (73), Expect = 0.86
 Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 11/96 (11%)

Query: 442 RWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQD------ESPVYCLEFNSQQT 495
           R+ P  P + A  +   DV +FD  K   KP    +   D      +   Y L +NS  +
Sbjct: 130 RYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLS 189

Query: 496 QLLAAGDAQGTVKVWQLSTEFTEQGPREAEDLDCLA 531
             L +     TV +W ++      GP+E + +D  A
Sbjct: 190 GHLLSASDDHTVCLWDINA-----GPKEGKIVDAKA 220


>gi|217272887 WD repeat domain 63 [Homo sapiens]
          Length = 891

 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 25/98 (25%), Positives = 44/98 (44%), Gaps = 13/98 (13%)

Query: 164 VTSISWNST--GSVVACAYGRLDHGDWSTLK-------SFVCAWNLDRRDLRPQQPSAVV 214
           +T +SW+ T  G +      RL   D            S +  W+       P  P  ++
Sbjct: 339 ITCVSWHPTIYGLIAVSVAVRLSFEDRVHFSGKLLLQPSLILFWSFSD----PIHPQLML 394

Query: 215 EVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLED 252
           E P  + C  F P+ P+ +AGG  +G++++WD++   D
Sbjct: 395 ESPDDIFCFKFCPSDPNIIAGGCINGQIVMWDITAHAD 432



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 34/142 (23%), Positives = 59/142 (41%), Gaps = 22/142 (15%)

Query: 391 HGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLV 450
           H G ++++  SPF+ ++ L+ G          +   PL     + K   +  WS  RP V
Sbjct: 671 HDGTVHTIQRSPFYNDIILTVGGWNVAIWKEGVMTGPLLQSCCAPKRYTSGHWSLTRPGV 730

Query: 451 FAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLE---------FNSQQTQLLAAG 501
           F      G + ++DL + + +P         +S   C+          F+S+Q Q +A  
Sbjct: 731 FYIGREDGYIDIWDLLEKTHEPA--------QSQNICITMITYIKPWIFSSKQ-QFIATA 781

Query: 502 DAQGTVKV----WQLSTEFTEQ 519
           D  GT+ +    W LS   T +
Sbjct: 782 DYYGTLHILEIPWTLSRPSTNE 803


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 21/194 (10%)

Query: 128 QSHAFDGFEVNW---------TEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVAC 178
           + H  +G+ ++W         +       CL+ +   P + + +   +I    T  V   
Sbjct: 139 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 198

Query: 179 AYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSA-VLCLAFHPTQPSHVAGGL 237
           ++  L    + ++         D R     +PS  V+  +A V CL+F+P     +A G 
Sbjct: 199 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 258

Query: 238 YSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVL-SVATDGKVL 296
               V +WDL  L+  L      + ++H D + QV W P     H   +L S  TD ++ 
Sbjct: 259 ADKTVALWDLRNLKLKL-----HSFESHKDEIFQVQWSP-----HNETILASSGTDRRLN 308

Query: 297 LWQGIGVGQLQLTE 310
           +W    +G+ Q  E
Sbjct: 309 VWDLSKIGEEQSPE 322



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/146 (23%), Positives = 61/146 (41%), Gaps = 6/146 (4%)

Query: 384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY---SMLQAPPLTSLQLSLKYLFA 440
           A+  F+ H   +  VS    H +LF S   D  + ++   S   + P  S+      +  
Sbjct: 184 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 243

Query: 441 VRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAA 500
           + ++P    + A  S    V L+DL+    K   L      +  ++ ++++     +LA+
Sbjct: 244 LSFNPYSEFILATGSADKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPHNETILAS 300

Query: 501 GDAQGTVKVWQLSTEFTEQGPREAED 526
                 + VW LS    EQ P +AED
Sbjct: 301 SGTDRRLNVWDLSKIGEEQSPEDAED 326



 Score = 36.2 bits (82), Expect = 0.077
 Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 12/126 (9%)

Query: 396 YSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFA--------VRWSPVR 447
           Y +S +P      LSA  D  + L+  + A P     +  K +F         V W  + 
Sbjct: 146 YGLSWNPNLSGHLLSASDDHTICLWD-ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 204

Query: 448 PLVFAAASGKGDVQLFDLQKSS-QKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGT 506
             +F + +    + ++D + ++  KP+  +     E  V CL FN     +LA G A  T
Sbjct: 205 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE--VNCLSFNPYSEFILATGSADKT 262

Query: 507 VKVWQL 512
           V +W L
Sbjct: 263 VALWDL 268


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 21/194 (10%)

Query: 128 QSHAFDGFEVNW---------TEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVAC 178
           + H  +G+ ++W         +       CL+ +   P + + +   +I    T  V   
Sbjct: 173 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 232

Query: 179 AYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSA-VLCLAFHPTQPSHVAGGL 237
           ++  L    + ++         D R     +PS  V+  +A V CL+F+P     +A G 
Sbjct: 233 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 292

Query: 238 YSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVL-SVATDGKVL 296
               V +WDL  L+  L      + ++H D + QV W P     H   +L S  TD ++ 
Sbjct: 293 ADKTVALWDLRNLKLKL-----HSFESHKDEIFQVQWSP-----HNETILASSGTDRRLN 342

Query: 297 LWQGIGVGQLQLTE 310
           +W    +G+ Q  E
Sbjct: 343 VWDLSKIGEEQSPE 356



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/146 (23%), Positives = 61/146 (41%), Gaps = 6/146 (4%)

Query: 384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY---SMLQAPPLTSLQLSLKYLFA 440
           A+  F+ H   +  VS    H +LF S   D  + ++   S   + P  S+      +  
Sbjct: 218 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 277

Query: 441 VRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAA 500
           + ++P    + A  S    V L+DL+    K   L      +  ++ ++++     +LA+
Sbjct: 278 LSFNPYSEFILATGSADKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPHNETILAS 334

Query: 501 GDAQGTVKVWQLSTEFTEQGPREAED 526
                 + VW LS    EQ P +AED
Sbjct: 335 SGTDRRLNVWDLSKIGEEQSPEDAED 360



 Score = 36.2 bits (82), Expect = 0.077
 Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 12/126 (9%)

Query: 396 YSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFA--------VRWSPVR 447
           Y +S +P      LSA  D  + L+  + A P     +  K +F         V W  + 
Sbjct: 180 YGLSWNPNLSGHLLSASDDHTICLWD-ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 238

Query: 448 PLVFAAASGKGDVQLFDLQKSS-QKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGT 506
             +F + +    + ++D + ++  KP+  +     E  V CL FN     +LA G A  T
Sbjct: 239 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE--VNCLSFNPYSEFILATGSADKT 296

Query: 507 VKVWQL 512
           V +W L
Sbjct: 297 VALWDL 302


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 44/194 (22%), Positives = 79/194 (40%), Gaps = 21/194 (10%)

Query: 128 QSHAFDGFEVNW---------TEQQQMVSCLYTLGYPPAQAQGLHVTSISWNSTGSVVAC 178
           + H  +G+ ++W         +       CL+ +   P + + +   +I    T  V   
Sbjct: 174 RGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDV 233

Query: 179 AYGRLDHGDWSTLKSFVCAWNLDRRDLRPQQPSAVVEVPSA-VLCLAFHPTQPSHVAGGL 237
           ++  L    + ++         D R     +PS  V+  +A V CL+F+P     +A G 
Sbjct: 234 SWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGS 293

Query: 238 YSGEVLVWDLSRLEDPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVL-SVATDGKVL 296
               V +WDL  L+  L      + ++H D + QV W P     H   +L S  TD ++ 
Sbjct: 294 ADKTVALWDLRNLKLKL-----HSFESHKDEIFQVQWSP-----HNETILASSGTDRRLN 343

Query: 297 LWQGIGVGQLQLTE 310
           +W    +G+ Q  E
Sbjct: 344 VWDLSKIGEEQSPE 357



 Score = 42.7 bits (99), Expect = 8e-04
 Identities = 34/146 (23%), Positives = 61/146 (41%), Gaps = 6/146 (4%)

Query: 384 AQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLY---SMLQAPPLTSLQLSLKYLFA 440
           A+  F+ H   +  VS    H +LF S   D  + ++   S   + P  S+      +  
Sbjct: 219 AKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNC 278

Query: 441 VRWSPVRPLVFAAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAA 500
           + ++P    + A  S    V L+DL+    K   L      +  ++ ++++     +LA+
Sbjct: 279 LSFNPYSEFILATGSADKTVALWDLRNLKLK---LHSFESHKDEIFQVQWSPHNETILAS 335

Query: 501 GDAQGTVKVWQLSTEFTEQGPREAED 526
                 + VW LS    EQ P +AED
Sbjct: 336 SGTDRRLNVWDLSKIGEEQSPEDAED 361



 Score = 36.2 bits (82), Expect = 0.077
 Identities = 32/126 (25%), Positives = 53/126 (42%), Gaps = 12/126 (9%)

Query: 396 YSVSCSPFHRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFA--------VRWSPVR 447
           Y +S +P      LSA  D  + L+  + A P     +  K +F         V W  + 
Sbjct: 181 YGLSWNPNLSGHLLSASDDHTICLWD-ISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLH 239

Query: 448 PLVFAAASGKGDVQLFDLQKSS-QKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGT 506
             +F + +    + ++D + ++  KP+  +     E  V CL FN     +LA G A  T
Sbjct: 240 ESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAE--VNCLSFNPYSEFILATGSADKT 297

Query: 507 VKVWQL 512
           V +W L
Sbjct: 298 VALWDL 303


>gi|116256340 SEC31 homolog A isoform 3 [Homo sapiens]
          Length = 1205

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 57/246 (23%), Positives = 91/246 (36%), Gaps = 47/246 (19%)

Query: 229 QPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDP---VSQVVWLPEPGHSHRFQ 285
           Q + VA G    E+ +WDL+    P+      T    T P   +S + W  +  H     
Sbjct: 134 QTNLVASGANESEIYIWDLNNFATPM------TPGAKTQPPEDISCIAWNRQVQHI---- 183

Query: 286 VLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRS--TKLKKHPRGETEVGATAVAFS 343
           + S +  G+  +W       L+  E    V     R   + L  HP       AT +  +
Sbjct: 184 LASASPSGRATVWD------LRKNEPIIKVSDHSNRMHCSGLAWHPDV-----ATQMVLA 232

Query: 344 SFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPF 403
           S D RL ++               +    R  SS PLR         H   I +++ S  
Sbjct: 233 SEDDRLPVI---------------QMWDLRFASS-PLRV-----LENHARGILAIAWSMA 271

Query: 404 HRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLF 463
              L LS G D  +   +      L  L  + ++ F ++W P  P V +AAS  G + ++
Sbjct: 272 DPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVY 331

Query: 464 DLQKSS 469
            +   S
Sbjct: 332 SIMGGS 337



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 6/88 (6%)

Query: 450 VFAAASGKGDVQLFDLQK--SSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTV 507
           V  A    G++ L+D  K  +  K  V+ +  +   PV  L+ N  QT L+A+G  +  +
Sbjct: 88  VLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEI 147

Query: 508 KVWQLSTEFTEQGP----REAEDLDCLA 531
            +W L+   T   P    +  ED+ C+A
Sbjct: 148 YIWDLNNFATPMTPGAKTQPPEDISCIA 175



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 41/232 (17%)

Query: 192 KSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLE 251
           +S +  W+L+     P  P A  + P  + C+A++      +A    SG   VWDL R  
Sbjct: 144 ESEIYIWDLNNF-ATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDL-RKN 201

Query: 252 DPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEG 311
           +P++    ++D ++    S + W P+        VL+   D            +L + + 
Sbjct: 202 EPII---KVSDHSNRMHCSGLAWHPDVATQ---MVLASEDD------------RLPVIQM 243

Query: 312 FALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAAL 371
           + L     P    L+ H R     G  A+A+S  DP L +L       + CS       L
Sbjct: 244 WDLRFASSPLRV-LENHAR-----GILAIAWSMADPEL-LLSCGKDAKILCSNPNTGEVL 296

Query: 372 TRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
             +P++       Q+ F         +   P +  +  +A  DG + +YS++
Sbjct: 297 YELPTN------TQWCF--------DIQWCPRNPAVLSAASFDGRISVYSIM 334



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 16/61 (26%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 452 AAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQ 511
           A+ + + ++ ++DL   +   T   K TQ    + C+ +N Q   +LA+    G   VW 
Sbjct: 139 ASGANESEIYIWDLNNFATPMTPGAK-TQPPEDISCIAWNRQVQHILASASPSGRATVWD 197

Query: 512 L 512
           L
Sbjct: 198 L 198


>gi|116256338 SEC31 homolog A isoform 1 [Homo sapiens]
          Length = 1220

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 57/246 (23%), Positives = 91/246 (36%), Gaps = 47/246 (19%)

Query: 229 QPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDP---VSQVVWLPEPGHSHRFQ 285
           Q + VA G    E+ +WDL+    P+      T    T P   +S + W  +  H     
Sbjct: 134 QTNLVASGANESEIYIWDLNNFATPM------TPGAKTQPPEDISCIAWNRQVQHI---- 183

Query: 286 VLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRS--TKLKKHPRGETEVGATAVAFS 343
           + S +  G+  +W       L+  E    V     R   + L  HP       AT +  +
Sbjct: 184 LASASPSGRATVWD------LRKNEPIIKVSDHSNRMHCSGLAWHPDV-----ATQMVLA 232

Query: 344 SFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPF 403
           S D RL ++               +    R  SS PLR         H   I +++ S  
Sbjct: 233 SEDDRLPVI---------------QMWDLRFASS-PLRV-----LENHARGILAIAWSMA 271

Query: 404 HRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLF 463
              L LS G D  +   +      L  L  + ++ F ++W P  P V +AAS  G + ++
Sbjct: 272 DPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVY 331

Query: 464 DLQKSS 469
            +   S
Sbjct: 332 SIMGGS 337



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 6/88 (6%)

Query: 450 VFAAASGKGDVQLFDLQK--SSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTV 507
           V  A    G++ L+D  K  +  K  V+ +  +   PV  L+ N  QT L+A+G  +  +
Sbjct: 88  VLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEI 147

Query: 508 KVWQLSTEFTEQGP----REAEDLDCLA 531
            +W L+   T   P    +  ED+ C+A
Sbjct: 148 YIWDLNNFATPMTPGAKTQPPEDISCIA 175



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 41/232 (17%)

Query: 192 KSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLE 251
           +S +  W+L+     P  P A  + P  + C+A++      +A    SG   VWDL R  
Sbjct: 144 ESEIYIWDLNNF-ATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDL-RKN 201

Query: 252 DPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEG 311
           +P++    ++D ++    S + W P+        VL+   D            +L + + 
Sbjct: 202 EPII---KVSDHSNRMHCSGLAWHPDVATQ---MVLASEDD------------RLPVIQM 243

Query: 312 FALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAAL 371
           + L     P    L+ H R     G  A+A+S  DP L +L       + CS       L
Sbjct: 244 WDLRFASSPLRV-LENHAR-----GILAIAWSMADPEL-LLSCGKDAKILCSNPNTGEVL 296

Query: 372 TRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
             +P++       Q+ F         +   P +  +  +A  DG + +YS++
Sbjct: 297 YELPTN------TQWCF--------DIQWCPRNPAVLSAASFDGRISVYSIM 334



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 16/61 (26%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 452 AAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQ 511
           A+ + + ++ ++DL   +   T   K TQ    + C+ +N Q   +LA+    G   VW 
Sbjct: 139 ASGANESEIYIWDLNNFATPMTPGAK-TQPPEDISCIAWNRQVQHILASASPSGRATVWD 197

Query: 512 L 512
           L
Sbjct: 198 L 198


>gi|116256336 SEC31 homolog A isoform 4 [Homo sapiens]
          Length = 1106

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 57/246 (23%), Positives = 91/246 (36%), Gaps = 47/246 (19%)

Query: 229 QPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDP---VSQVVWLPEPGHSHRFQ 285
           Q + VA G    E+ +WDL+    P+      T    T P   +S + W  +  H     
Sbjct: 134 QTNLVASGANESEIYIWDLNNFATPM------TPGAKTQPPEDISCIAWNRQVQHI---- 183

Query: 286 VLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRS--TKLKKHPRGETEVGATAVAFS 343
           + S +  G+  +W       L+  E    V     R   + L  HP       AT +  +
Sbjct: 184 LASASPSGRATVWD------LRKNEPIIKVSDHSNRMHCSGLAWHPDV-----ATQMVLA 232

Query: 344 SFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPF 403
           S D RL ++               +    R  SS PLR         H   I +++ S  
Sbjct: 233 SEDDRLPVI---------------QMWDLRFASS-PLRV-----LENHARGILAIAWSMA 271

Query: 404 HRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLF 463
              L LS G D  +   +      L  L  + ++ F ++W P  P V +AAS  G + ++
Sbjct: 272 DPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVY 331

Query: 464 DLQKSS 469
            +   S
Sbjct: 332 SIMGGS 337



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 6/88 (6%)

Query: 450 VFAAASGKGDVQLFDLQK--SSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTV 507
           V  A    G++ L+D  K  +  K  V+ +  +   PV  L+ N  QT L+A+G  +  +
Sbjct: 88  VLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEI 147

Query: 508 KVWQLSTEFTEQGP----REAEDLDCLA 531
            +W L+   T   P    +  ED+ C+A
Sbjct: 148 YIWDLNNFATPMTPGAKTQPPEDISCIA 175



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 41/232 (17%)

Query: 192 KSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLE 251
           +S +  W+L+     P  P A  + P  + C+A++      +A    SG   VWDL R  
Sbjct: 144 ESEIYIWDLNNF-ATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDL-RKN 201

Query: 252 DPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEG 311
           +P++    ++D ++    S + W P+        VL+   D            +L + + 
Sbjct: 202 EPII---KVSDHSNRMHCSGLAWHPDVATQ---MVLASEDD------------RLPVIQM 243

Query: 312 FALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAAL 371
           + L     P    L+ H R     G  A+A+S  DP L +L       + CS       L
Sbjct: 244 WDLRFASSPLRV-LENHAR-----GILAIAWSMADPEL-LLSCGKDAKILCSNPNTGEVL 296

Query: 372 TRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
             +P++       Q+ F         +   P +  +  +A  DG + +YS++
Sbjct: 297 YELPTN------TQWCF--------DIQWCPRNPAVLSAASFDGRISVYSIM 334



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 16/61 (26%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 452 AAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQ 511
           A+ + + ++ ++DL   +   T   K TQ    + C+ +N Q   +LA+    G   VW 
Sbjct: 139 ASGANESEIYIWDLNNFATPMTPGAK-TQPPEDISCIAWNRQVQHILASASPSGRATVWD 197

Query: 512 L 512
           L
Sbjct: 198 L 198


>gi|41349441 SEC31 homolog A isoform 2 [Homo sapiens]
          Length = 1181

 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 57/246 (23%), Positives = 91/246 (36%), Gaps = 47/246 (19%)

Query: 229 QPSHVAGGLYSGEVLVWDLSRLEDPLLWRTGLTDDTHTDP---VSQVVWLPEPGHSHRFQ 285
           Q + VA G    E+ +WDL+    P+      T    T P   +S + W  +  H     
Sbjct: 134 QTNLVASGANESEIYIWDLNNFATPM------TPGAKTQPPEDISCIAWNRQVQHI---- 183

Query: 286 VLSVATDGKVLLWQGIGVGQLQLTEGFALVMQQLPRS--TKLKKHPRGETEVGATAVAFS 343
           + S +  G+  +W       L+  E    V     R   + L  HP       AT +  +
Sbjct: 184 LASASPSGRATVWD------LRKNEPIIKVSDHSNRMHCSGLAWHPDV-----ATQMVLA 232

Query: 344 SFDPRLFILGTEGGFPLKCSLAAGEAALTRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPF 403
           S D RL ++               +    R  SS PLR         H   I +++ S  
Sbjct: 233 SEDDRLPVI---------------QMWDLRFASS-PLRV-----LENHARGILAIAWSMA 271

Query: 404 HRNLFLSAGTDGHVHLYSMLQAPPLTSLQLSLKYLFAVRWSPVRPLVFAAASGKGDVQLF 463
              L LS G D  +   +      L  L  + ++ F ++W P  P V +AAS  G + ++
Sbjct: 272 DPELLLSCGKDAKILCSNPNTGEVLYELPTNTQWCFDIQWCPRNPAVLSAASFDGRISVY 331

Query: 464 DLQKSS 469
            +   S
Sbjct: 332 SIMGGS 337



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 25/88 (28%), Positives = 42/88 (47%), Gaps = 6/88 (6%)

Query: 450 VFAAASGKGDVQLFDLQK--SSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTV 507
           V  A    G++ L+D  K  +  K  V+ +  +   PV  L+ N  QT L+A+G  +  +
Sbjct: 88  VLIAGGENGNIILYDPSKIIAGDKEVVIAQNDKHTGPVRALDVNIFQTNLVASGANESEI 147

Query: 508 KVWQLSTEFTEQGP----REAEDLDCLA 531
            +W L+   T   P    +  ED+ C+A
Sbjct: 148 YIWDLNNFATPMTPGAKTQPPEDISCIA 175



 Score = 34.7 bits (78), Expect = 0.23
 Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 41/232 (17%)

Query: 192 KSFVCAWNLDRRDLRPQQPSAVVEVPSAVLCLAFHPTQPSHVAGGLYSGEVLVWDLSRLE 251
           +S +  W+L+     P  P A  + P  + C+A++      +A    SG   VWDL R  
Sbjct: 144 ESEIYIWDLNNF-ATPMTPGAKTQPPEDISCIAWNRQVQHILASASPSGRATVWDL-RKN 201

Query: 252 DPLLWRTGLTDDTHTDPVSQVVWLPEPGHSHRFQVLSVATDGKVLLWQGIGVGQLQLTEG 311
           +P++    ++D ++    S + W P+        VL+   D            +L + + 
Sbjct: 202 EPII---KVSDHSNRMHCSGLAWHPDVATQ---MVLASEDD------------RLPVIQM 243

Query: 312 FALVMQQLPRSTKLKKHPRGETEVGATAVAFSSFDPRLFILGTEGGFPLKCSLAAGEAAL 371
           + L     P    L+ H R     G  A+A+S  DP L +L       + CS       L
Sbjct: 244 WDLRFASSPLRV-LENHAR-----GILAIAWSMADPEL-LLSCGKDAKILCSNPNTGEVL 296

Query: 372 TRMPSSVPLRAPAQFTFSPHGGPIYSVSCSPFHRNLFLSAGTDGHVHLYSML 423
             +P++       Q+ F         +   P +  +  +A  DG + +YS++
Sbjct: 297 YELPTN------TQWCF--------DIQWCPRNPAVLSAASFDGRISVYSIM 334



 Score = 31.2 bits (69), Expect = 2.5
 Identities = 16/61 (26%), Positives = 29/61 (47%), Gaps = 1/61 (1%)

Query: 452 AAASGKGDVQLFDLQKSSQKPTVLIKQTQDESPVYCLEFNSQQTQLLAAGDAQGTVKVWQ 511
           A+ + + ++ ++DL   +   T   K TQ    + C+ +N Q   +LA+    G   VW 
Sbjct: 139 ASGANESEIYIWDLNNFATPMTPGAK-TQPPEDISCIAWNRQVQHILASASPSGRATVWD 197

Query: 512 L 512
           L
Sbjct: 198 L 198


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.131    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,168,020
Number of Sequences: 37866
Number of extensions: 1124363
Number of successful extensions: 4400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 4048
Number of HSP's gapped (non-prelim): 419
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.