Search of human proteins with 62865641

Search of human proteins with 62865641

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
         (290 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|62865641 aurora kinase C isoform 2 [Homo sapiens]                  590   e-169
gi|62865639 aurora kinase C isoform 1 [Homo sapiens]                  588   e-168
gi|62865643 aurora kinase C isoform 3 [Homo sapiens]                  561   e-160
gi|83776600 aurora kinase B [Homo sapiens]                            476   e-134
gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]          397   e-111
gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]          397   e-111
gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]          397   e-111
gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]          397   e-111
gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]          397   e-111
gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]          397   e-111
gi|121114283 polo-like kinase 4 [Homo sapiens]                        182   3e-46
gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]        178   6e-45
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor...   174   1e-43
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor...   174   1e-43
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor...   174   1e-43
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform...   174   1e-43
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s...   173   1e-43
gi|217330634 serine/threonine kinase 36 [Homo sapiens]                171   5e-43
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ...   171   7e-43
gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]               171   9e-43
gi|116256471 SNF1-like kinase [Homo sapiens]                          169   2e-42
gi|28557781 protein kinase C, eta [Homo sapiens]                      169   3e-42
gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent ...   169   3e-42
gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform...   167   8e-42
gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo ...   167   8e-42
gi|254028240 MAP/microtubule affinity-regulating kinase 2 isofor...   165   4e-41
gi|254028237 MAP/microtubule affinity-regulating kinase 2 isofor...   165   4e-41
gi|254028234 MAP/microtubule affinity-regulating kinase 2 isofor...   165   4e-41
gi|254028232 MAP/microtubule affinity-regulating kinase 2 isofor...   165   4e-41
gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform...   165   4e-41

>gi|62865641 aurora kinase C isoform 2 [Homo sapiens]
          Length = 290

 Score =  590 bits (1520), Expect = e-169
 Identities = 290/290 (100%), Positives = 290/290 (100%)

Query: 1   MATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI 60
           MATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI
Sbjct: 1   MATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI 60

Query: 61  EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD 120
           EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD
Sbjct: 61  EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD 120

Query: 121 EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM 180
           EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM
Sbjct: 121 EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM 180

Query: 181 CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 240
           CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP
Sbjct: 181 CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 240

Query: 241 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 290
           LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 241 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 290


>gi|62865639 aurora kinase C isoform 1 [Homo sapiens]
          Length = 309

 Score =  588 bits (1517), Expect = e-168
 Identities = 289/290 (99%), Positives = 290/290 (100%)

Query: 1   MATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI 60
           +ATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI
Sbjct: 20  LATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI 79

Query: 61  EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD 120
           EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD
Sbjct: 80  EKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLD 139

Query: 121 EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM 180
           EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM
Sbjct: 140 EQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTM 199

Query: 181 CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 240
           CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP
Sbjct: 200 CGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFP 259

Query: 241 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 290
           LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 260 LSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 309


>gi|62865643 aurora kinase C isoform 3 [Homo sapiens]
          Length = 275

 Score =  561 bits (1446), Expect = e-160
 Identities = 275/275 (100%), Positives = 275/275 (100%)

Query: 16  MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 75
           MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI
Sbjct: 1   MRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEI 60

Query: 76  QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 135
           QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL
Sbjct: 61  QAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADAL 120

Query: 136 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 195
           TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR
Sbjct: 121 TYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGR 180

Query: 196 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 255
           TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL
Sbjct: 181 TYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLL 240

Query: 256 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 290
           RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
Sbjct: 241 RYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS 275


>gi|83776600 aurora kinase B [Homo sapiens]
          Length = 344

 Score =  476 bits (1225), Expect = e-134
 Identities = 228/270 (84%), Positives = 250/270 (92%)

Query: 17  RRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQ 76
           R  T+DDFEIGRPLGKGKFGNVYLAR K+SHFIVALKVLFKSQIEKEG+EHQLRREIEIQ
Sbjct: 70  RHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQ 129

Query: 77  AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 136
           AHL HPNILRLYNYF+D RR+YLILEYAPRGELYKELQKS   DEQRTATI+EELADAL 
Sbjct: 130 AHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALM 189

Query: 137 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRT 196
           YCH KKVIHRDIKPENLLLG +GE+KIADFGWSVH PSLRRKTMCGTLDYLPPEMIEGR 
Sbjct: 190 YCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRM 249

Query: 197 YDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 256
           ++EKVDLWCIGVLCYELLVG PPFESASH+ETYRRI+KVD++FP S+P+GA+DLIS+LLR
Sbjct: 250 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLR 309

Query: 257 YQPLERLPLAQILKHPWVQAHSRRVLPPCA 286
           + P ERLPLAQ+  HPWV+A+SRRVLPP A
Sbjct: 310 HNPSERLPLAQVSAHPWVRANSRRVLPPSA 339


>gi|38327572 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score =  397 bits (1019), Expect = e-111
 Identities = 189/272 (69%), Positives = 226/272 (83%)

Query: 9   QQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQ 68
           Q+      R+  ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQ
Sbjct: 118 QKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ 177

Query: 69  LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATII 128
           LRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK  K DEQRTAT I
Sbjct: 178 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI 237

Query: 129 EELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLP 188
            ELA+AL+YCH K+VIHRDIKPENLLLG  GE+KIADFGWSVH PS RR T+CGTLDYLP
Sbjct: 238 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLP 297

Query: 189 PEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGAR 248
           PEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+  FP  +  GAR
Sbjct: 298 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGAR 357

Query: 249 DLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
           DLISRLL++ P +R  L ++L+HPW+ A+S +
Sbjct: 358 DLISRLLKHNPSQRPMLREVLEHPWITANSSK 389


>gi|38327570 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score =  397 bits (1019), Expect = e-111
 Identities = 189/272 (69%), Positives = 226/272 (83%)

Query: 9   QQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQ 68
           Q+      R+  ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQ
Sbjct: 118 QKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ 177

Query: 69  LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATII 128
           LRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK  K DEQRTAT I
Sbjct: 178 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI 237

Query: 129 EELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLP 188
            ELA+AL+YCH K+VIHRDIKPENLLLG  GE+KIADFGWSVH PS RR T+CGTLDYLP
Sbjct: 238 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLP 297

Query: 189 PEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGAR 248
           PEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+  FP  +  GAR
Sbjct: 298 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGAR 357

Query: 249 DLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
           DLISRLL++ P +R  L ++L+HPW+ A+S +
Sbjct: 358 DLISRLLKHNPSQRPMLREVLEHPWITANSSK 389


>gi|38327568 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score =  397 bits (1019), Expect = e-111
 Identities = 189/272 (69%), Positives = 226/272 (83%)

Query: 9   QQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQ 68
           Q+      R+  ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQ
Sbjct: 118 QKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ 177

Query: 69  LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATII 128
           LRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK  K DEQRTAT I
Sbjct: 178 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI 237

Query: 129 EELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLP 188
            ELA+AL+YCH K+VIHRDIKPENLLLG  GE+KIADFGWSVH PS RR T+CGTLDYLP
Sbjct: 238 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLP 297

Query: 189 PEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGAR 248
           PEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+  FP  +  GAR
Sbjct: 298 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGAR 357

Query: 249 DLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
           DLISRLL++ P +R  L ++L+HPW+ A+S +
Sbjct: 358 DLISRLLKHNPSQRPMLREVLEHPWITANSSK 389


>gi|38327566 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score =  397 bits (1019), Expect = e-111
 Identities = 189/272 (69%), Positives = 226/272 (83%)

Query: 9   QQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQ 68
           Q+      R+  ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQ
Sbjct: 118 QKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ 177

Query: 69  LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATII 128
           LRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK  K DEQRTAT I
Sbjct: 178 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI 237

Query: 129 EELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLP 188
            ELA+AL+YCH K+VIHRDIKPENLLLG  GE+KIADFGWSVH PS RR T+CGTLDYLP
Sbjct: 238 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLP 297

Query: 189 PEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGAR 248
           PEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+  FP  +  GAR
Sbjct: 298 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGAR 357

Query: 249 DLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
           DLISRLL++ P +R  L ++L+HPW+ A+S +
Sbjct: 358 DLISRLLKHNPSQRPMLREVLEHPWITANSSK 389


>gi|38327564 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score =  397 bits (1019), Expect = e-111
 Identities = 189/272 (69%), Positives = 226/272 (83%)

Query: 9   QQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQ 68
           Q+      R+  ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQ
Sbjct: 118 QKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ 177

Query: 69  LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATII 128
           LRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK  K DEQRTAT I
Sbjct: 178 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI 237

Query: 129 EELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLP 188
            ELA+AL+YCH K+VIHRDIKPENLLLG  GE+KIADFGWSVH PS RR T+CGTLDYLP
Sbjct: 238 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLP 297

Query: 189 PEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGAR 248
           PEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+  FP  +  GAR
Sbjct: 298 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGAR 357

Query: 249 DLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
           DLISRLL++ P +R  L ++L+HPW+ A+S +
Sbjct: 358 DLISRLLKHNPSQRPMLREVLEHPWITANSSK 389


>gi|38327562 serine/threonine protein kinase 6 [Homo sapiens]
          Length = 403

 Score =  397 bits (1019), Expect = e-111
 Identities = 189/272 (69%), Positives = 226/272 (83%)

Query: 9   QQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQ 68
           Q+      R+  ++DFEIGRPLGKGKFGNVYLAR K+S FI+ALKVLFK+Q+EK G+EHQ
Sbjct: 118 QKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQ 177

Query: 69  LRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATII 128
           LRRE+EIQ+HL+HPNILRLY YFHDA RVYLILEYAP G +Y+ELQK  K DEQRTAT I
Sbjct: 178 LRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI 237

Query: 129 EELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLP 188
            ELA+AL+YCH K+VIHRDIKPENLLLG  GE+KIADFGWSVH PS RR T+CGTLDYLP
Sbjct: 238 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLP 297

Query: 189 PEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGAR 248
           PEMIEGR +DEKVDLW +GVLCYE LVG PPFE+ ++ ETY+RI +V+  FP  +  GAR
Sbjct: 298 PEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGAR 357

Query: 249 DLISRLLRYQPLERLPLAQILKHPWVQAHSRR 280
           DLISRLL++ P +R  L ++L+HPW+ A+S +
Sbjct: 358 DLISRLLKHNPSQRPMLREVLEHPWITANSSK 389


>gi|121114283 polo-like kinase 4 [Homo sapiens]
          Length = 970

 Score =  182 bits (462), Expect = 3e-46
 Identities = 91/261 (34%), Positives = 150/261 (57%), Gaps = 3/261 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           ++DF++G  LGKG F  VY A    +   VA+K++ K  + K G+  +++ E++I   L+
Sbjct: 9   IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 68

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEK-LDEQRTATIIEELADALTYCH 139
           HP+IL LYNYF D+  VYL+LE    GE+ + L+   K   E      + ++   + Y H
Sbjct: 69  HPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLH 128

Query: 140 DKKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTY 197
              ++HRD+   NLLL     +KIADFG +  +  P  +  T+CGT +Y+ PE+     +
Sbjct: 129 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAH 188

Query: 198 DEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRY 257
             + D+W +G + Y LL+G PPF++ +   T  +++  D   P  + + A+DLI +LLR 
Sbjct: 189 GLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRR 248

Query: 258 QPLERLPLAQILKHPWVQAHS 278
            P +RL L+ +L HP++  +S
Sbjct: 249 NPADRLSLSSVLDHPFMSRNS 269


>gi|38569491 serine/threonine-protein kinase QSK [Homo sapiens]
          Length = 1263

 Score =  178 bits (451), Expect = 6e-45
 Identities = 98/272 (36%), Positives = 154/272 (56%), Gaps = 8/272 (2%)

Query: 24  FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 83
           +EI R +GKG F  V  A    +   VA+K++ K+Q+++E L+ ++ RE++I   L HP+
Sbjct: 8   YEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLK-KIFREVQIMKMLCHPH 66

Query: 84  ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 143
           I+RLY      R +YL+ EYA  GE++  L    ++ E+      +++  A+ +CH + +
Sbjct: 67  IIRLYQVMETERMIYLVTEYASGGEIFDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNI 126

Query: 144 IHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD-EKV 201
           +HRD+K ENLLL     +KIADFG+S + TP    KT CG+  Y  PE+ EG+ YD  KV
Sbjct: 127 VHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKV 186

Query: 202 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 261
           D+W +GV+ Y L+ G  PF+ ++      R+L    R P  M      LI  +L   P +
Sbjct: 187 DIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 246

Query: 262 RLPLAQILKHPWVQ-----AHSRRVLPPCAQM 288
           RL + QI KH W++      +  R++  C Q+
Sbjct: 247 RLSMEQICKHKWMKLGDADPNFDRLIAECQQL 278


>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
           [Homo sapiens]
          Length = 713

 Score =  174 bits (440), Expect = 1e-43
 Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YLI+EYA  GE++  L    ++ E+   +   ++  A+ YCH 
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K+++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ R L   
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291

Query: 259 PLERLPLAQILKHPWVQA-HSRRVLPP 284
           P++R  L QI+K  W+ A H    L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318


>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
           [Homo sapiens]
          Length = 744

 Score =  174 bits (440), Expect = 1e-43
 Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YLI+EYA  GE++  L    ++ E+   +   ++  A+ YCH 
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K+++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ R L   
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291

Query: 259 PLERLPLAQILKHPWVQA-HSRRVLPP 284
           P++R  L QI+K  W+ A H    L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318


>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
           [Homo sapiens]
          Length = 753

 Score =  174 bits (440), Expect = 1e-43
 Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YLI+EYA  GE++  L    ++ E+   +   ++  A+ YCH 
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K+++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ R L   
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291

Query: 259 PLERLPLAQILKHPWVQA-HSRRVLPP 284
           P++R  L QI+K  W+ A H    L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318


>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
           [Homo sapiens]
          Length = 729

 Score =  174 bits (440), Expect = 1e-43
 Identities = 95/267 (35%), Positives = 151/267 (56%), Gaps = 4/267 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 53  IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ-KLFREVRIMKILN 111

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YLI+EYA  GE++  L    ++ E+   +   ++  A+ YCH 
Sbjct: 112 HPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQ 171

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K+++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 172 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDG 231

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ R L   
Sbjct: 232 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLN 291

Query: 259 PLERLPLAQILKHPWVQA-HSRRVLPP 284
           P++R  L QI+K  W+ A H    L P
Sbjct: 292 PIKRGTLEQIMKDRWINAGHEEDELKP 318


>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
           sapiens]
          Length = 688

 Score =  173 bits (439), Expect = 1e-43
 Identities = 91/256 (35%), Positives = 143/256 (55%), Gaps = 3/256 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           V ++ + R +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 56  VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ-KLFREVRIMKGLN 114

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 115 HPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQ 174

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 175 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDG 234

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M      ++ R L   
Sbjct: 235 PEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLN 294

Query: 259 PLERLPLAQILKHPWV 274
           P +R  L QI+K  W+
Sbjct: 295 PAKRCTLEQIMKDKWI 310


>gi|217330634 serine/threonine kinase 36 [Homo sapiens]
          Length = 1315

 Score =  171 bits (434), Expect = 5e-43
 Identities = 95/266 (35%), Positives = 153/266 (57%), Gaps = 4/266 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           ++ + +   +G+G FG VY  R K S  +VALK + K    ++ L + L+REIEI   L+
Sbjct: 1   MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRN-LQREIEIMRGLR 59

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI+ + + F   + V ++ +YA  GEL++ L+   KL E +   I  +L  AL Y H 
Sbjct: 60  HPNIVHMLDSFETDKEVVVVTDYA-EGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHS 118

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS--VHTPSLRRKTMCGTLDYLPPEMIEGRTYD 198
            +++HRD+KP+N+LL   G +K+ DFG++  + T ++   ++ GT  Y+ PE++E R YD
Sbjct: 119 HRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYD 178

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
              DLW +G + YEL VG PPF + S  +    ILK  VR+P ++    ++ +  LL   
Sbjct: 179 HTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKD 238

Query: 259 PLERLPLAQILKHPWVQAHSRRVLPP 284
           P +RL    +L HP++  H   +  P
Sbjct: 239 PRQRLSWPDLLYHPFIAGHVTIITEP 264


>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
           sapiens]
          Length = 795

 Score =  171 bits (433), Expect = 7e-43
 Identities = 93/267 (34%), Positives = 149/267 (55%), Gaps = 4/267 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 57  IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ-KLFREVRIMKILN 115

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 116 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 175

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 176 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDG 235

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ +LL   
Sbjct: 236 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLN 295

Query: 259 PLERLPLAQILKHPWVQ-AHSRRVLPP 284
           P++R  L QI+K  W+   H    L P
Sbjct: 296 PIKRGSLEQIMKDRWMNVGHEEEELKP 322


>gi|7662170 AMPK-related protein kinase 5 [Homo sapiens]
          Length = 661

 Score =  171 bits (432), Expect = 9e-43
 Identities = 95/253 (37%), Positives = 141/253 (55%), Gaps = 3/253 (1%)

Query: 24  FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPN 83
           +E+   LGKG +G V  A  + S  +VA+K + K +I+ E     +RREIEI + L HP+
Sbjct: 55  YELQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPH 114

Query: 84  ILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKV 143
           I+ +Y  F +  ++ +I+EYA +GELY  + +  +L E+ T     ++  A+ YCH   V
Sbjct: 115 IISIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGV 174

Query: 144 IHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTY-DEKV 201
           +HRD+K EN+LL     +KIADFG S ++      +T CG+  Y  PE++ GR Y   +V
Sbjct: 175 VHRDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEV 234

Query: 202 DLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLE 261
           D W +GVL Y L+ G  PF+   H    R+I   + R P + P  AR LI  +L   P  
Sbjct: 235 DSWALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREP-TQPSDARGLIRWMLMVNPDR 293

Query: 262 RLPLAQILKHPWV 274
           R  +  I  H WV
Sbjct: 294 RATIEDIANHWWV 306


>gi|116256471 SNF1-like kinase [Homo sapiens]
          Length = 783

 Score =  169 bits (429), Expect = 2e-42
 Identities = 91/269 (33%), Positives = 150/269 (55%), Gaps = 3/269 (1%)

Query: 19  LTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAH 78
           L V  ++I R LGKG F  V LAR + +   VA+K++ K++++   LE ++ RE+++   
Sbjct: 22  LRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLE-KIYREVQLMKL 80

Query: 79  LQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYC 138
           L HP+I++LY        +Y++ E+A  GE++  L  +  L E        ++  A+ YC
Sbjct: 81  LNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYC 140

Query: 139 HDKKVIHRDIKPENLLLGFRGEVKIADFGW-SVHTPSLRRKTMCGTLDYLPPEMIEGRTY 197
           HD  ++HRD+K ENLLL    ++K+ADFG+ + +       T CG+  Y  PE+ EG+ Y
Sbjct: 141 HDHHIVHRDLKTENLLLDGNMDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEY 200

Query: 198 D-EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLR 256
           +  ++D+W +GV+ Y L+ G  PF+  +     +R+L+   R P  M      LI R+L 
Sbjct: 201 EGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLV 260

Query: 257 YQPLERLPLAQILKHPWVQAHSRRVLPPC 285
             P  R+ +AQI +H W++A      P C
Sbjct: 261 VDPARRITIAQIRQHRWMRAEPCLPGPAC 289


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  169 bits (427), Expect = 3e-42
 Identities = 99/282 (35%), Positives = 152/282 (53%), Gaps = 15/282 (5%)

Query: 18  RLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQI-EKEGLEHQLRREIEIQ 76
           RL +D+FE  R LGKG FG V LAR+KE+  + A+KVL K  I + + +E  +  +  + 
Sbjct: 349 RLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILS 408

Query: 77  AHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALT 136
               HP + +L+  F    R++ ++E+   G+L   +QKS + DE R      E+  AL 
Sbjct: 409 LARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALM 468

Query: 137 YCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVH--TPSLRRKTMCGTLDYLPPEMIEG 194
           + HDK +I+RD+K +N+LL   G  K+ADFG         +   T CGT DY+ PE+++ 
Sbjct: 469 FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE 528

Query: 195 RTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRL 254
             Y   VD W +GVL YE+L G+ PFE+ +  + +  IL  +V +P  +   A  ++   
Sbjct: 529 MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSF 588

Query: 255 LRYQPLERL-PLAQ-----ILKHP------WVQAHSRRVLPP 284
           +   P  RL  L Q     IL+HP      W Q + R++ PP
Sbjct: 589 MTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPP 630


>gi|239756427 PREDICTED: similar to 3-phosphoinositide dependent
           protein kinase-1 [Homo sapiens]
          Length = 471

 Score =  169 bits (427), Expect = 3e-42
 Identities = 97/276 (35%), Positives = 148/276 (53%), Gaps = 6/276 (2%)

Query: 6   QTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGL 65
           Q AQ P  P  +R   +DF+ G+ LG+G F  V LAR   +    A+K+L K  I KE  
Sbjct: 85  QHAQPPPQPRKKR--PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 142

Query: 66  EHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTA 125
              + RE ++ + L HP  ++LY  F   RR+Y  L YA  GEL K ++K    DE  T 
Sbjct: 143 VPYVTRERDVMSRLDHPFFVKLYFTFQTTRRLYFGLSYAKNGELLKYIRKIGSFDETCTR 202

Query: 126 TIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG----WSVHTPSLRRKTMC 181
               E+  AL Y H K +IHRD+KPEN+LL     ++I DFG     S  +   R  +  
Sbjct: 203 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 262

Query: 182 GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 241
           GT  Y+ PE++  ++  +  DLW +G + Y+L+ G PPF + +    +++I+K++  FP 
Sbjct: 263 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE 322

Query: 242 SMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH 277
                ARDL+ +LL     +RL   ++  +  ++AH
Sbjct: 323 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 358


>gi|4505695 3-phosphoinositide dependent protein kinase-1 isoform 1
           [Homo sapiens]
          Length = 556

 Score =  167 bits (424), Expect = 8e-42
 Identities = 96/276 (34%), Positives = 148/276 (53%), Gaps = 6/276 (2%)

Query: 6   QTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGL 65
           Q AQ P  P  +R   +DF+ G+ LG+G F  V LAR   +    A+K+L K  I KE  
Sbjct: 66  QHAQPPPQPRKKR--PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 123

Query: 66  EHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTA 125
              + RE ++ + L HP  ++LY  F D  ++Y  L YA  GEL K ++K    DE  T 
Sbjct: 124 VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTR 183

Query: 126 TIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG----WSVHTPSLRRKTMC 181
               E+  AL Y H K +IHRD+KPEN+LL     ++I DFG     S  +   R  +  
Sbjct: 184 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 243

Query: 182 GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 241
           GT  Y+ PE++  ++  +  DLW +G + Y+L+ G PPF + +    +++I+K++  FP 
Sbjct: 244 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE 303

Query: 242 SMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH 277
                ARDL+ +LL     +RL   ++  +  ++AH
Sbjct: 304 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 339


>gi|239745384 PREDICTED: hypothetical protein XP_002343452 [Homo
           sapiens]
          Length = 396

 Score =  167 bits (424), Expect = 8e-42
 Identities = 96/276 (34%), Positives = 148/276 (53%), Gaps = 6/276 (2%)

Query: 6   QTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGL 65
           Q AQ P  P  +R   +DF+ G+ LG+G F  V LAR   +    A+K+L K  I KE  
Sbjct: 39  QHAQPPPQPRKKR--PEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENK 96

Query: 66  EHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTA 125
              + RE ++ + L HP  ++LY  F D  ++Y  L YA  GEL K ++K    DE  T 
Sbjct: 97  VPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTR 156

Query: 126 TIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFG----WSVHTPSLRRKTMC 181
               E+  AL Y H K +IHRD+KPEN+LL     ++I DFG     S  +   R  +  
Sbjct: 157 FYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFV 216

Query: 182 GTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPL 241
           GT  Y+ PE++  ++  +  DLW +G + Y+L+ G PPF + +    +++I+K++  FP 
Sbjct: 217 GTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPE 276

Query: 242 SMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAH 277
                ARDL+ +LL     +RL   ++  +  ++AH
Sbjct: 277 KFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAH 312


>gi|254028240 MAP/microtubule affinity-regulating kinase 2 isoform f
           [Homo sapiens]
          Length = 709

 Score =  165 bits (418), Expect = 4e-41
 Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ + L   
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288

Query: 259 PLERLPLAQILKHPWV 274
           P +R  L QI+K  W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304


>gi|254028237 MAP/microtubule affinity-regulating kinase 2 isoform e
           [Homo sapiens]
          Length = 719

 Score =  165 bits (418), Expect = 4e-41
 Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ + L   
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288

Query: 259 PLERLPLAQILKHPWV 274
           P +R  L QI+K  W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304


>gi|254028234 MAP/microtubule affinity-regulating kinase 2 isoform d
           [Homo sapiens]
          Length = 788

 Score =  165 bits (418), Expect = 4e-41
 Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ + L   
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288

Query: 259 PLERLPLAQILKHPWV 274
           P +R  L QI+K  W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304


>gi|254028232 MAP/microtubule affinity-regulating kinase 2 isoform c
           [Homo sapiens]
          Length = 724

 Score =  165 bits (418), Expect = 4e-41
 Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 50  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 108

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 109 HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 168

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 169 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 228

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ + L   
Sbjct: 229 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 288

Query: 259 PLERLPLAQILKHPWV 274
           P +R  L QI+K  W+
Sbjct: 289 PSKRGTLEQIMKDRWM 304


>gi|86990441 MAP/microtubule affinity-regulating kinase 2 isoform a
           [Homo sapiens]
          Length = 745

 Score =  165 bits (418), Expect = 4e-41
 Identities = 89/256 (34%), Positives = 144/256 (56%), Gaps = 3/256 (1%)

Query: 21  VDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQ 80
           + ++ + + +GKG F  V LAR   +   VA+K++ K+Q+    L+ +L RE+ I   L 
Sbjct: 17  IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ-KLFREVRIMKVLN 75

Query: 81  HPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHD 140
           HPNI++L+      + +YL++EYA  GE++  L    ++ E+       ++  A+ YCH 
Sbjct: 76  HPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQ 135

Query: 141 KKVIHRDIKPENLLLGFRGEVKIADFGWS-VHTPSLRRKTMCGTLDYLPPEMIEGRTYD- 198
           K ++HRD+K ENLLL     +KIADFG+S   T   +  T CG+  Y  PE+ +G+ YD 
Sbjct: 136 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDG 195

Query: 199 EKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQ 258
            +VD+W +GV+ Y L+ G  PF+  +  E   R+L+   R P  M     +L+ + L   
Sbjct: 196 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILN 255

Query: 259 PLERLPLAQILKHPWV 274
           P +R  L QI+K  W+
Sbjct: 256 PSKRGTLEQIMKDRWM 271


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.139    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,395,845
Number of Sequences: 37866
Number of extensions: 503451
Number of successful extensions: 3633
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 752
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 1021
Number of HSP's gapped (non-prelim): 1012
length of query: 290
length of database: 18,247,518
effective HSP length: 101
effective length of query: 189
effective length of database: 14,423,052
effective search space: 2725956828
effective search space used: 2725956828
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.